text:
The stock of PDL BioPharma Inc (NASDAQ:PDLI) hit a new 52-week low and has $2.40 target or 4.00% below today's $2.50 share price. The 7 months bearish chart indicates high risk for the $405.72M company. The 1-year low was reported on Nov, 28 by Barchart.com. If the $2.40 price target is reached, the company will be worth $16.23 million less.
The 52-week low event is an important milestone for every stock because it shows very negative momentum and is time when sellers come in. During such technical setups, fundamental investors usually stay away and are careful buying the stock. About 158,021 shares traded hands. PDL BioPharma Inc (NASDAQ:PDLI) has declined 31.90% since April 25, 2016 and is downtrending. It has underperformed by 37.92% the S&P500.
Analysts await PDL BioPharma Inc (NASDAQ:PDLI) to report earnings on February, 27. They expect $0.16 EPS, down 73.77% or $0.45 from last year's $0.61 per share. PDLI's profit will be $25.97M for 3.91 P/E if the $0.16 EPS becomes a reality. After $0.11 actual EPS reported by PDL BioPharma Inc for the previous quarter, Wall Street now forecasts 45.45% EPS growth.
PDL BioPharma Inc (NASDAQ:PDLI) Ratings Coverage
Out of 2 analysts covering PDL BioPharma (NASDAQ:PDLI), 0 rate it a "Buy", 0 "Sell", while 2 "Hold". This means 0 are positive. $7 is the highest target while $4 is the lowest. The $4 average target is 60.00% above today's ($2.5) stock price. PDL BioPharma has been the topic of 5 analyst reports since October 16, 2015 according to StockzIntelligence Inc. The firm has "Sector Perform" rating given on Tuesday, February 2 by RBC Capital Markets. The stock of PDL BioPharma Inc (NASDAQ:PDLI) has "Sector Perform" rating given on Friday, October 16 by RBC Capital Markets. The firm has "Sector Perform" rating given on Thursday, November 5 by RBC Capital Markets. RBC Capital Markets maintained the stock with "Sector Perform" rating in Tuesday, February 23 report.
According to Zacks Investment Research, "Protein Design Labs Inc. is a biopharmaceutical company focused on the research, development and commercialization of novel therapies for inflammation and autoimmune diseases, acute cardiac conditions and cancer. PDL markets several biopharmaceutical products in the United States through its hospital sales force and wholly-owned subsidiary, ESP Pharma, Inc. As a leader in the development of humanized antibodies, PDL has licensed its patents to numerous pharmaceutical and biotechnology companies, some of which are now paying royalties on net sales of licensed products."
Insitutional Activity: The institutional sentiment decreased to 1 in 2016 Q2. Its down 0.23, from 1.23 in 2016Q1. The ratio fall, as 20 funds sold all PDL BioPharma Inc shares owned while 51 reduced positions. 23 funds bought stakes while 64 increased positions. They now own 118.91 million shares or 4.03% less from 123.91 million shares in 2016Q1.
Numeric Invsts Ltd Liability holds 1.04M shares or 0.03% of its portfolio. Denali Ltd holds 0% or 330 shares in its portfolio. Moreover, Blackrock Advsrs Limited Liability Co has 0% invested in PDL BioPharma Inc (NASDAQ:PDLI) for 374,748 shares. Rbf Ltd Liability Co holds 0.17% of its portfolio in PDL BioPharma Inc (NASDAQ:PDLI) for 273,976 shares. Cornerstone Management Ltd Liability holds 477,200 shares or 0.01% of its portfolio. Envestnet Asset Mgmt Incorporated has 0% invested in the company for 7,088 shares. The British Columbia – Canada-based Pacad Ltd has invested 0.06% in PDL BioPharma Inc (NASDAQ:PDLI). The New Jersey-based Blackrock Invest Mngmt Ltd Com has invested 0% in PDL BioPharma Inc (NASDAQ:PDLI). Sei Invs accumulated 0% or 572 shares. Principal Fincl Gp holds 0% or 28,302 shares in its portfolio. Spot Trading Ltd Liability Company last reported 6,800 shares in the company. First Republic Management, a California-based fund reported 71,074 shares. Glenmede Tru Na holds 0% of its portfolio in PDL BioPharma Inc (NASDAQ:PDLI) for 393 shares. Janney Montgomery Scott Lc holds 0% of its portfolio in PDL BioPharma Inc (NASDAQ:PDLI) for 35,904 shares. The Massachusetts-based Wellington Management Group Llp has invested 0% in PDL BioPharma Inc (NASDAQ:PDLI).
Insider Transactions: Since August 9, 2016, the stock had 1 buy, and 0 sales for $29,950 net activity. 10,000 shares were bought by GARCIA PETER S, worth $29,950 on Tuesday, August 9.
More notable recent PDL BioPharma Inc (NASDAQ:PDLI) news were published by: Fool.com which released: "Why PDL BioPharma Inc. Is Down 14.8% Today" on November 23, 2016, also Prnewswire.com with their article: "PDL BioPharma Issues $150.0 Million of 2.75% Convertible Senior Notes Due 2021" published on November 22, 2016, Prnewswire.com published: "PDL BioPharma to Present at the 28th Annual Piper Jaffray Healthcare Conference" on November 22, 2016. More interesting news about PDL BioPharma Inc (NASDAQ:PDLI) were released by: Fool.com and their article: "Can PDL BioPharma, Inc. Turn Things Around?" published on October 28, 2016 as well as Prnewswire.com's news article titled: "PDL BioPharma Prices Public Offering of $150.0 Million of 2.75% Convertible …" with publication date: November 17, 2016.
PDLI Company Profile
PDL BioPharma, Inc., formerly Protein Design Labs, Inc., incorporated on July 24, 1986, manages a portfolio of patents and royalty assets, consisting of its Queen et al. patents, license agreements with various biotechnology and pharmaceutical companies, and royalty and other assets acquired. The Firm provides non-dilutive growth capital and financing solutions to late-stage public and private healthcare companies and offers immediate financial monetization of royalty streams to companies, academic institutions and inventors. The Firm evaluates its investments based on the quality of the income generating assets and potential returns on investment. It is focused on intellectual property asset management, acquiring income generating assets and maximizing value for its stockholders, among others.
Receive News & Ratings Via Email - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings with our FREE daily email newsletter.


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This is how they try lower your IQ so you don't ask many questions about governance. #NairobiDiaries
Storming a place of worship is wrong, BUT when some of the "worshippers" turn it into an armory, it stops being a place of worship.
Zambia is in confusion. VP is a white dude, and is not of Zambia origin. He is supposed to take over on death of President
#IStandWithKDF and say a prayer for each of their souls, for their families. They died protecting us. Let's NEVER forget that!
On this day I always remember the 42 young cops killed in Baragoi, and pray for their souls and their families. #MashujaaDay

subset: commoncrawl


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Humanities Center News
Acting Director, New Associate Director For Humanities Center
With Humanities Center Director Lori Lefkovitz on sabbatical, the Center is pleased to introduce Laura Green as Acting Director for Fall 2016. A member and former chair (2009-2015) of the department of English, Laura specializes in Victorian literature, the novel, and gender and literature. She is co-chair of the Victorian Literature and Culture Seminar at…
Read more »
Congratulations to the 2016-17 "Inclusions and Exclusions" Faculty and Graduate Fellows
Please join us in congratulating the Northeastern University faculty and graduate fellows selected for the fourth annual Northeastern University Humanities Center Resident Fellowship Program. This fellowship provides a focused period of time for 7 faculty fellows and 2 graduate fellows to pursue research, to collaborate around a common theme, and to share their work with…
Read more »
Northeastern kicks-off Holocaust Awareness Week with heartrending presentation
January 26, 2016 by Jason Kornwitz Published by News@Northeastern "The images sear themselves into your heart and soul," said Jeffrey Burds, associate professor of history at Northeastern University. "They bring you to a certain level of consciousness." It was Monday, and Burds was giving a slideshow presentation at Northeastern's Holocaust Commemoration in the Raytheon Amphitheater,…
Read more »
Humanities Center Events
Northeastern Holocaust Commemoration
"The Search for Meaning: Survivors' Children and Their Choice of a Life in the Law," Rose Zoltek-Jick, Associate Teaching Professor, Northeastern University School of Law "The Portraitist: Wilhelm Brasse and Photography Ethics in Auschwitz," Alison Campbell, Gideon Klein Scholar, Northeastern University '17, International Affairs and Political Science
Jr. Survivor Talk: Philip N. Backstrom
Anna Ornstein, M.D. Professor Emerita of Child Psychiatry, University of Cincinnati Author, "My Mother's Eyes: Holocaust Memories of a Young Girl"
Bill Giessen Film Screening
"What Our Fathers Did: A Nazi Legacy," followed by a Q&A session with Philippe Sands, Professor of Laws and Director of the Centre on International Courts and Tribunals, University College London, moderated by Natalie Bormann, Associate Teaching Professor, Department of Political Science
25th Annual Robert Salomon Morton Lecture
"East West Street: A Personal Account of Genocide and Crimes Against Humanity" Philippe Sands, Professor of Laws and Director of the Centre on International Courts and Tribunals, University College London
Frank Capogna
Ph.D Candidate, Department of English, Humanities Center Graduate Fellow
My current research examines how Anglophone modernist poets responded to the rise of the art museum, an institution that took shape in Western countries during the nineteenth century...
Sana Tannoury-Karam
Ph.D Candidate, Department of History, Humanities Center Graduate Fellow
My current research is an intellectual and cultural history of a generation of Lebanese and Syrian communists who had been excluded from the communist party and its circles as a result of their ideological heterogeneity...


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Slide to see the images
Estimated DOB is 7/26/2013
The smallest of the boys in the litter of 4, BC was a bit shy. He quietly saunters up to the food bowl while being very cautious. He is a bit unsure at first but in no time he figures it all out. BC has a very loud purr and LOVES to have his belly rubbed. He is easily enteretained and plays well with the other cats living with him. He is curious about dogs, but only for a quick moment, then it's on to play time.
For more photos of BC visit http://www.adoptapet.com/pet/10902702-houston-texas-cat
If you are interested in BC and would like to fill out a Cat Adoption Application, please go to: http://www.homelesspets.net/adoption-forms/cat-adoption.php Submitting an application does not obligate you to adopt BC but it initiates contact with us and gets the process started. If you have questions prior to filling out the application for BC, email us at email@example.com and a volunteer will get back to you.


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Thread: .htaccess with cgi
12-26-2006, 03:41 PM #1Web Hosting Master
- Join Date
- Feb 2005
- Posts
- 1,076
.htaccess with cgi
I put the following in my .htaccess
PHP Code:
<IfModule mod_rewrite.c>
RewriteEngine On
RewriteBase /
RewriteCond %{REQUEST_FILENAME} !-f
RewriteCond %{REQUEST_FILENAME} !-d
RewriteRule . /index.php?keyquery=blabla [L]
my site will call http//domainname.com/index.php?keyquery=blabla instead. Latter, in index.php, I can do stuffs like $keyquery = $_GET['keyquery'];
There is one annoying fact though.
http//domainname.com/ is requested by the browser, the server will give http//domainname.com/index.php rather than http//domainname.com/index.php?keyquery=blabla
In other words, $keyquery = $_GET['keyquery']; in index.php will give nothing.
How do I ensure that when the server access http//domainname.com/ it'll also display the content of http//domainname.com/index.php?keyquery=blabla
One solution I tried is to delete RewriteCond %{REQUEST_FILENAME} !-f
However, I simply got:
The server encountered an internal error or misconfiguration and was unable to complete your request.
Please contact the server administrator, [email protected] and inform them of the time the error occurred, and anything you might have done that may have caused the error.
More information about this error may be available in the server error log.
Additionally, a 500 Internal Server Error error was encountered while trying to use an ErrorDocument to handle the request.
It seems that it means the server tries to access http//domainname.com/index.php?keyquery=blabla however, the .htaccess directive tries to redirect it to http//domainname.com/index.php?keyquery=blabla, which will try to redirect it to http//domainname.com/index.php?keyquery=blabla, and so on and so on.
That's why delete RewriteCond %{REQUEST_FILENAME} !-f is needed.


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The Electronic Privacy Information Center (EPIC) is suing the U.S. Federal Trade Commission in the hopes of stopping the new Google privacy policy, which is set to become effective March 1. The complaint was filed today in a Washington, D.C., federal district court.
EPIC alleges that the changes to Google's privacy policies, which will allow Google to combine user data across all of its properties "without user consent," violates a consent order Google signed with the FTC last year related to Google Buzz.
"Google's recent announcement that the company intends to consolidate users' personal information without individuals' consent violates the consent order and threatens to harm consumers," according to the complaint. "The FTC is required to enforce the consent order. But the Commission has failed to due [sic] so."
The suit also alleges that the privacy policy change will "make it possible for advertisers to gain access to personal information which was previously unavailable to them."
A Google spokesperson told Bloomberg this isn't true: "We are not collecting any new information or sharing it with third parties."
Google announced plans to consolidate more than 60 policies into one "simplified" easy-to-read privacy policy, that Google said "makes clear that, if you're signed in, we may combine information you've provided from one service with information from other services. In short, we'll treat you as a single user across all our products, which will mean a simpler, more intuitive Google experience."
In the hours after the new privacy policy was announced, the lack of an "opt out" became the big issue, and many accused Google of going evil (yet again). With growing pressure from lawmakers, Google reminded everyone that you don't have to log-in to use all of Google's services (e.g., you don't have to sign into a Google account to search or view videos on YouTube).
Executives went to Washington, D.C., to defend the privacy policy changes, though it didn't seem to solve much. Meanwhile, the EU asked Google to hold off on implementing the policy, though Google wasn't receptive to that idea. Google also dealt with public attacks by Microsoft.
Google has not yet commented on the lawsuit. You can read the full complaint (PDF) here.
Related reading
Five most interesting search news stories of the week
Welcome to our weekly round-up of all the latest news and research from the world of search marketing and beyond.
Inclusive marketing: the need to remove binary data
Last week Metro Bank became the first financial institution to offer a gender neutral option for both its staff and customers.
How marketing will change when 5G and VR collide
5G networks are expected to start rolling out this coming year and will likely be standard in 2018.
Five most important search marketing news stories of the week
This week, both LinkedIn and Facebook are beefing up their paid social offerings in different ways, while Google seeks to cut off Adwords revenues for fake news sites. And might Google be favouring desktop over its own AMP in its upcoming mobile-first index?


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Alyce Claudine 2514 Striking 2pc Formal Dress
Price: $797.99
YOUR CREDIT CARD WILL NOT BE CHARGED until we determine that your dress is available to be shipped to you by your "wear date."
Style 2514 from Alyce Claudine is a striking two-piece stretch luxe formal dress that will make you look exquisite on your big night. The bateau top features gorgeous pearls draped from the neckline and a sheer back while the skirt is simply elegant.
Colors: Black/Diamond White, Diamond White/Diamond White
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Please use Size Chart 1.
Fabric: Stretch Luxe
Home > Evening Dresses and Suits > Alyce Paris Claudine Evening Dresses
Home > Prom Dresses > Alyce Paris Claudine


text:
54 's
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Every detail I asked for, the seller delivered! Love the cake topper. The seller does awesome work.
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On Second Thought is a one-hour, daily news talk show that airs at 9 a.m. ET weekdays.
Celebrated blues rock master, Joe Bonamassa delivers a musical tribute to The Three Kings Of the Blues at the legendary Greek Theatre. Saturday, December 3 at 8:30 PM
High School Football is Back, and so is Football Fridays on GPB!
The long wait is finally over. Yes, I went to some spring practices. Sure I checked out some 7 on 7 action this summer. Of course I... MORE
GPB Passport is the new member benefit that provides you with extended access to an on-demand library of quality local and national public television programming, including tens of thousands of hours of your favorite programs.
Tue., December 16, 2014 4:30pm
Plant Vogtle Nuclear Power Plant Price Tag Soars, Construction Delayed
A public watchdog says the construction of a nuclear power plant in Georgia is running a year late, a lag that could trigger big expenses.
Full Story
Thu., October 18, 2012 2:00am
Safer Reactors Focus Of Research
Georgia Tech researchers are getting $6 million to a lead a team looking at new, safer designs for the next generation of nuclear reactors. Engineers want to create an "inherently safe" design.
Thu., August 23, 2012 6:02am
Nuclear Cos. Want Navy Vets
The U.S. Navy and members of the nuclear power industry have signed a deal meant to help Navy veterans with specialized training find civilian jobs.
Sat., October 1, 2011 3:28am
Radioactive Water Found Under Plant Hatch
Radioactive water has been found underneath the nuclear power station Plant Hatch in southeast Georgia, but officials said it does not pose an immediate threat to public health. Madison and state officials said the radioactive water appears confined to a small area at the site. They say there's little or no chance it could get into drinking water.
Tue., March 8, 2011 8:41am
Nuke Plant Could Get OK By Summer
The chairman of the U.S. Nuclear Regulatory Commission says a final decision on whether to approve several new nuclear reactor designs could come as early as this summer.
Wed., February 3, 2010 1:36pm
Commissioners Want Money Back
After a decades-long proposal and long-term financing for Yucca Mountain nu


text:
Co-curated by Michael Hackett and Frances Mill, and made possible by the willingness of private collectors and one institution to lend rare works, Interiors and Places is an exceptionally beautiful show that makes a valuable point.
Read Whole Story
Get top stories and blog posts emailed to me each day. Newsletters may offer personalized content or advertisements. Learn more.


text:
Description of this paper
analyze the effects of each of the transactions li...
analyze the effects of each of the transactions listed below on the current assets, current liabilities, fund balance, or net assets of each of the fund or nonfund accounts of the city of nancy, virginia. also note how the government-wide net assets would be affected by changes in the nonfund. indicate how each transaction would be reported in the operating statement for each fund affected. 1 salaries and wages for firefighters and police officers incurred but not paid $75,000 3 the city paid $5,000,000 to finance construction of a new city executive office building by issing bonds at par
Paper#12897 | Written in 18-Jul-2015Price : $25


text:
A user going by the remarkably simple handle "email123" announced on the xda-developers forum, that WM6.1 is here, alive and kicking. But he doesn't stop there, he says that its available "now", that too for an HTC wizard, a 3 year old phone (which I own as well). Thats not all, he goes on to provide the proof by linking in his cooked ROM for all to download. But, here is the clincher, he claims that finally "Big Storage" is available for wizard, a feat noone has been able to achieve in the last 3 years. It means that an extra 10 MB is available to you as Device Memory. It seems to get better and better for our dear old wizard. After all, old is gold.
Click here to go to the thread, the link is in the first post. And do not forget to let us know if you did try out that ROM.
[tags]WM6.1, Windows Mobile, HTC, wizard, HTC wizard, ROM, xda-developers[/tags]


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Home » Dvd » Standard Dvd's » Laguna Productions Semilla De Odio [dvd/1999/spanish]
Laguna Productions Semilla De Odio [dvd/1999/spanish]
Oops! It appears we are out of stock or no longer selling this product.
Model: LAGDAP8830D
Search Beach Audio for similar products
Studio: Laguna Productions Inc
Release Date: 06/22/2006
Release Date: 06/22/2006
Warranty Information
|Beach Audio Warranty
This product was added to our catalog on Tuesday, February 03, 2009.


text:
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text:
Joan Cohen, an expert teacher/lecturer on opera, will discuss the anti-Semitism facing nineteenth-century Jewish composers.
Subscribe To our E-Newsletter
Explore MLRT's history and view memorabilia from our past during this special Shabbat celebration that includes a roundtable discussion with founding members. Reception and traditional Mediterranean dinner at 6:00 pm; Shabbat Evening Service at 8:00 pm.
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text:
Does this restaurant specialize in Cantonese food?
Is this restaurant appropriate for Kids?
Is this a Chinese restaurant?
Is this restaurant good for dining on a budget?
Is this restaurant wheelchair accessible?
Is this restaurant family-friendly?
Is this restaurant good for brunch?
Is this restaurant good for breakfast?
Does this restaurant offer takeout or food to go?
Does this restaurant offer free wifi?
Thanks for helping!
3 Days in Montreal
One Day in Montreal
Museum Guide for Montreal
Had salt and pepper porc chop they so delicious....the giger lobster was equally tasty ...this now my favorite restaurant to go to when ever im in town
This restaurant served authentic Cantonese dishes, almost as good as food in Guangzhou, China. We didn't expect we would have such great food in Montreal. Actually we went there for both lunch and dinner in 1 day. The pricing is also reasonable.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


text:
You missed it This great deal for B & N Painting is over. But don't despair, we've got more great deals every day.
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text:
ERIC Number: ED192382
Record Type: RIE
Publication Date: 1980
Pages: 61
Abstractor: N/A
Reference Count: 0
Perspectives on Non-Policy Argument.
Brownlee, Don, Ed.
The purpose of this booklet is to disseminate limited-circulation papers relating to value proposition debating (nonpolicy argument). The six papers provide information on the following topics: the theoretical implications of debating nonpolicy propositions, criteria for evaluating nonpolicy argument, situationally guided standards for evaluating propositions of judgment, the use of the hypothesis-testing paradigm to establish presumption in value proposition debate, advocacy and values, and a pragmatic approach to value proposition debate. (FL)
Descriptors: Debate, Evaluation Criteria, Persuasive Discourse, Rhetoric, Speech Communication, Values
Publication Type: Collected Works - General; Information Analyses; Speeches/Meeting Papers
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers: Value Proposition Debate
Note: Papers presented to the Speech Communication Association Convention (Washington, DC, December 2, 1977).


text:
Yard Sale (2005)
Critic Consensus: No consensus yet.
Yard Sale Photos
Movie Info
as Cassette Customer
as Golf Putter Customer
as Roscoe
as Woman Tossing Clothes
as Mr. Tyler
as Harley Atwater
as Margarite
as Mrs. Funny Tie
as Gerald Williamson
as Gunther
as Xavier's Partner
as Mr. Detweiler
as Nellie
as Man at Mailbox
as Cop #1
as Denise
as Little Boy
as Pizza Delivery Man
as Mr. Funny Tie
as Mark Farnwell
as Cup Buyer
as Renee Atwater
as Marion Williamson
as Egg Lady
as Dr. DiCenzo
as Ken
as Toaster Oven Customer
as Mr. Burton
as Abel Fields
as Morley
as Alma
as Lindsay
as Housewife
as Cassie Lawton
as Mailman
as Todd
as Sean
as Wheelchair Customer
as Emmitt
as Little Boy
as Cop #2
as Kelly
as CD Buying Wife
as Waiter
as Yuppie Wife
as Pizza Delivery Man
as Janet Farnwell
as Gang Member #3
as Victor
as M. L. LeBell
as April
as Young Girl
as Yvette
as Broach Lady
as Yuppie Husband
as Gang Member #2
as Wilford
as Gang Member #1
as DeLeon
as Tamara
as Middle Aged Man
as Baseball Bat Customer
as Beilaz Rahman
as Baby
as Not-So-Gay Divorcee
as House Admirer
as Cash Admirer
as Annaud Rahman
as Alan
as CD Buying Husband
as Elizabeth
as Reynolds
as Father Stephen Byers
as Janet Farnwell
as Woman Customer
as Chrissy Deavers
as Susan
as Xavier
as Pants Buyer
as Dog
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text:
This week on the show, Hollywood star Tom Hanks, actor Simon Pegg and singer and new X Factor judge, Nicole Scherzinger join Graham Norton for a chat.
Asked what is happening on US X Factor, Nicole says: "I haven't said this yet, but I think it's official that I have been made a judge."
Describing it as an "amazing opportunity" she adds: "I'm kind of finding out (what's happening) along with everyone else. It's kind of crazy to read about it in the newspaper first."
And, on working with Simon Cowell, Nicole says: "He is someone you can learn a lot from. But when we are in that room it's all about the music and the talent and I focus on the contestants, its what I am really passionate about."
Asked if he as been following the X Factor dramas, Tom says: "It's front page news my friend, along with bad salads out of Germany – it's the biggest news you can possibly get!"
Talking about the success of his career, Tom is amazed to be told that his films have grossed eight billion dollars: "Really? That is news to me! That's extraordinary." And, put to the test by Graham, Tom successfully lists his early movies in quick succession before adding: "It all becomes a blur after that."
On making Apollo 13 he says: "It was the first time I was acting with only two other guys and the jokes became so filthy as of lunch time on the first day. And Kevin Bacon and Bill Paxton, who were in the capsule with me, know the foulest jokes and we were trying to out-foul and out-gross each other and that's how we spent our trip to the moon."
Tom, talking about his recent Royal encounter, says: "I was with The Queen and the President just last week and as an American I kept thinking, 'How did this happen? Did I win a ticket?' We got an email from the White House saying 'the President and Mrs Obama would like you to join them for dinner at Buckingham Palace' and I was chatting to Her Majesty and we compared notes on Shakespeare."
Simon, who met The Queen at the premier of Narnia, says: "I have it on good authority that I made her cry. There is a sweet scene at the end of the movie and The Queen is sitting there wearing 3-D glasses, which is a sight to behold! They weren't even gold plated on a stick but just plastic Buddy Holly style 3-D glasses ones – and she dabbed her eye with a tissue."
Talking about performing for Prince Charles and Camilla, Nicole is reminded by Graham that the Pussycat Dolls choice of song was Don't You Wish Your Girlfriend Was Hot Like Me, to which she says: "It's a really empowering song. We were just giving that day!"
Modestly talking about her new movie role, she says: "I am in Men In Black III. It's a cameo role but I open the entire film. It's pretty cool and I have a bad-ass outfit – it's a lot of leather."
Talking about her first solo album, before performing Right There live in the studio, Nicole says: "I miss the girls obviously because we were like this girl gang, a force to be reckoned with, but I grew up on the stage and I love it so I'm having a great time."
And asked if there will be wedding bells for her and Lewis (Hamilton), she says: "Well I'm really proud of us that we have made it to three years. Just last week was our anniversary and that's not too bad as we live on opposite sides of the universe so we've made it work. Right now we are really happy where we are."
Revealing themselves huge Star Trek fans, Tom and Simon challenge each other to trekkie trivia questions. Having great fun and revelling in the subject, Tom says: "Are we a bunch of losers or what?"
And finally, Graham pulls the lever on foolhardy members of the audience brave enough to sit in the red chair.
The Graham Norton Show, BBC One, Friday 10 June at 10.35pm


text:
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
Discuss the article on the Forums.
Depressive symptoms and pragmatic rehabilitation for chronic fatigue syndrome (FINE Trial paper)
Discussion in 'Latest ME/CFS Research' started by Dolphin, Jul 26, 2012.
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1.5kW - 200kW Electric Compressors for hire
- Title
- 1.5kW - 200kW Electric Compressors
- Condition
- Excellent
- Number in Fleet
- 20
More Information - 1.5kW - 200kW Electric Compressors
PremiAir Hire has on offer an unsurpassed range of Stationary Electric Air Compressors from 15cfm to 1500cfm varying in pressure from 7 bar (100psi) to high pressure 15 bar (215 psi). Whether you require an outright purchase, periodic hire or a Hire-Buy arrangement, We can accommodate your needs. PremiAir Hire has the expertise to design and build customised electric compressed air and filtration solutions for any application, including oil free, instrument and breathing quality air. We are committed to delivering the most efficient and economical solution to your stationary electric compressed air requirements, 24/7.
PremiAir Services Pty Ltd has this item available for hire nationwide from :
Archerfield , Beresfield , Chinchilla , Eastern Creek , Gladstone , Hume , Huntingwood , Kilburn , Melbourne , Parkes , Port Kembla
PremiAir Services Pty Ltd
- Address
26 Clay Place
- Website
- View Website


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Healthy herbs! This Community is all about herbs and their medicinal and culinary uses. Do you live in harmony with herbs? Then check out these healthy and delicious sites!
Donndez-Pueblo Herb Lady
Donndez, the Pueblo Herb Lady, shares her centuries-old information and stories. A traditionally-raised Native American from the Southwest, her information is informative and simple. Rather than relying ...
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{;}A list of herbs and their healing properties, as well as links to other helpful sites.
Spiral and Joker's Love Story
{;}Come and visit :a site that takes you all over the country as traveling nurses growing herbs and learning what climate they like and dislike
Herbal Healing Teaching site. Learn how to: Wildcraft, make oils, tinctures, potions. List and research of healing plants (datapage) and illness list with proper remedies and recipes. Home of the SummerWinds ...
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ome on a mystical journey to The World of Wolfspirit. {;} Light your candle and follow me.....{;}Look over there are some mystical journeys where you can {;}visit Atlantis, Lemuria, or even go on a true ...
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This site contains info on various pagan paths, including wicca and witchcraft. It also has sections on herbs, aromatherapy, moon phases and divination.
Mega Nutrition
One of the largest vitamin, herb, nutritional, weight loss, sports and body building supplement sites on the Internet with hundreds of deeply discounted products at savings of 30%-60% off of retail.{; ...
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My gardening page, which contains info about gardening with herbs and organic gardening.
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Over the years I have collected thousands of home remedies and special recipes for all sorts of ailments from friends, family, penpals, and from emails. So I decided to add this collection to my web pages. ...
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text:
Created both for those living with the condition and those who work with people who have Cerebral Palsy, this course provides a wealth of information and practical advice that will aid in helping those affected to live independent, self-sufficient lives.
Over the years, treatments for persons with Cerebral Palsy have become increasingly more progressive. The Cerebral Palsy Awareness Diploma Course looks at treatments from both traditional and complementary medicine. With more options than ever before, these treatments can lead to less pain, reduced spasticity, a higher level of independent movement, and a sense of being able to participate more fully in life than ever before.
Learning how to deal with the day-to-day is an important part of living with Cerebral Palsy. The course discusses the benefits of having a support system in place, should extra help be needed, and details self-advocacy techniques and strategies that can be used to build confidence and independence. You will also learn about the 6 major aspects of life in which a sense of wellbeing can enable a person to make positive changes.
Knowing your rights is an important part of living with Cerebral Palsy. The course discusses the wider world of disability rights, the law, and strategies/accommodations that can ensure the best possible integration in school and work environments.
The course looks through the history of Cerebral Palsy, including the various movements that have improved public perception and changed attitudes. You will discover how treatments have evolved over time and how current research may change future therapies. You will also learn about common symptoms in babies that are indicative of Cerebral Palsy and what the specific medical causes of the condition are, both congenital and acquired. A glossary of terms is included to ensure comprehension.
Independence, self-sufficiency, and self-advocacy are three of the most important things to any person, so these are of course important to someone with Cerebral Palsy. The Cerebral Palsy Awareness Course explains how those caring for individuals with the condition can work with them to help them gain independence, and the systems, support, and technologies that are in place to accomplish this.
Fitness and wellness should be important to everyone, but for those with Cerebral Palsy, it can make a big difference to their quality of life. The course explains the ways in which those with the condition can exercise and even guides through some exercise routines that target specific areas. Also covered is the importance of proper nutrition and how to prepare and take in food.
The Cerebral Palsy Awareness Diploma Course offers knowledge and practical advice both to those living with the condition and practitioners who work with people who have CP. The course will also be of interest to friends and family members of those who have Cerebral Palsy and anyone who is interested in pursuing a career in this area.
The Cerebral Palsy Awareness Diploma Course will take you up to 150 hours to complete working from home. There is no time limit for completing this course, it can be studied in your own time at your own pace. The course comes with a course assessment in the form of quizzes, written questions and short essays, once you have completed your course assessment please email or post it back to us for marking, you will then receive your feedback and certificates.
This course is certified by the IANLPC (International Association of NLP & Coaching) and the IAHT (International Alliance of Holistic Therapists), both of which are internationally recognised organisations. The IAHT certify personal development, health, fitness and nutrition courses. The IANLPC is a global support network for NLP Professionals and coaches, including the fields of Life Coaching, Hypnotherapy Business Coaching, Leadership, Nutritional, CBT, Personal Development and Holistic Therapy.
Our courses include comprehensive support, should you require any assistance. You can contact our friendly course advisers by telephone or by email.
All course delegates are welcome to attend our regular, ongoing learning and inspirational events. We also hold regular inspirational events in Manchester and London for all students studying any of our courses. The events are a great way to watch live demonstrations of different techniques, learn new skills, have a practice with other students and to meet your tutors. Once you've signed up for any of our courses you will receive details of our different monthly events via email. If you cannot attend our events you can watch a live streaming of the event on our tv channel.
All courses can be paid for using our secure online payment system or via paypal.
If you would prefer to pay via bacs payment or via cheque please email us at firstname.lastname@example.com or call us on 0800 955 6808 for more assistance.
All of the online course materials are emailed over to you as e-documents, if you would prefer a hard copy of the course materials to be posted out to you please select this when checking out.


text:
Graduate Systems Engineer (Airborne & Space)
Leonardo – Ingenuity at your service
Do you want to work on real-time projects alongside leading scientists and engineers within a globally renowned company?
Leonardo has an award winning Graduate Programme that develops promising young graduates into engineers and business professionals of the future.
Leonardo is an international leader in electronic and information technologies for defence systems, aerospace, data, infrastructures, land security and protection and sustainable 'smart' solutions. We are globally renowned and are continually expanding, offering exciting opportunities to talented graduates who want to work at the forefront of our technology. With the majority of our engineers having chartered status, you can look forward to working with highly skilled professionals that are passionate about their work.
- Our technology defines the capability of the Eurofighter Typhoon
- Our products help to return service men and women safely home to their families
- Our surveillance radar helps coastguards to save lives of people lost at sea
- Our thermal camera has commercial uses such as on the BBC's Winter Watch
- Our perimeter security offered protection during the Commonwealth Games
- Our Airborne Infra-Red Counter Measures, Radar and Laser Designators are number 1 outside of the US
Our 2 year Graduate Programme
On joining the Leonardo graduate programme, you will unlock a wealth of development opportunities and further learning. You will receive mentoring, coaching and support to achieve your personal goals and accreditation from your professional body.
We have created a programme across our UK sites that not only increases your professional skills through hands on experience on some of our largest projects, but also helps to develop your leadership and business skills. You will receive mentoring, coaching and support to achieve your personal goals, whilst working towards accreditation within your chosen profession.
We value those who continuously ask questions and look to resolve problems through creative and innovative thinking. We will demand a high degree of customer focus and work performance from you in order to meet our operational challenges.
Our key competencies we look for and develop are:
- Achieving High Performance
- Continuously Improving
- Customer Focus
- Working Together
- Personal: Self Awareness & Confidence
- Technical: Analysis, Judgement & Problem Solving
The graduate programme offers the perfect springboard to a successful and enjoyable future career with Leonardo.
Graduate Systems Engineer (Airborne & Space) Job Description
The Support and Service Solutions (S3) line of business operates across all of the main UK sites, providing innovative and invaluable support solutions to our customers. S3 is part of the Airborne and Space Systems Division, which develops and produces a wide range of products and solutions for both manned and unmanned aircraft platforms, including integrated mission systems, airborne radars and sensors, protection and countermeasure systems, on-board avionics, and simulation systems.
Would you like the opportunity to create innovative systems? Can you imagine yourself using new technology to solve future medical or energy problems? Do you like the idea of working directly with customers and end users across the UK? If so, then why not join the growing S3 engineering community and work alongside some of the most talented engineers in the UK.
As a graduate systems engineer within S3, you will be part of a team developing support system architectures and concept solutions, and looking at cost effective support of equipment through its life. By using mathematical analysis and modelling, you can help to ensure that the end user has equipment that will be reliable and easy to maintain in challenging environments. You might also look at how technology can be applied to provide a service that addresses current and future global issues.
Key Responsibilities
Working as part of a systems engineering community and supported by a team of experienced engineers, you will be responsible for:
- Developing and applying your academic knowledge to undertake various activities across the engineering lifecycle, delivering to agreed performance targets, including cost and schedule.
- Developing practical skills in engineering design and development for complex solutions, understanding key processes and technologies.
- Working closely with engineers across multiple disciplines to solve problems.
- Completing tasks to a high standard and in accordance with appropriate processes and procedures.
- Taking an active role in engineering process improvement, ensuring the communication of best practise across the engineering team.
- Using technical expertise to solve problems, generate ideas and be pro-active within the team.
Role Requirements
- Must have obtained or are predicted to obtain a minimum of an upper second class honours degree in a relevant discipline (e.g. physics, mathematics, electronic engineering, systems engineering, avionics or other related science or engineering subject).
- You must be able to obtain SC security clearance (if necessary) and have a minimum of 5 years permanent residency in the UK.
- Ability to demonstrate and apply system-level thinking
- Self-motivated with an aptitude for problem solving and an ability to drive difficult issues to conclusion
- Able to work with minimum direction/supervision on complex tasks
- Excellent communication and inter-personal skills, and the ability to interact with subject matter experts regarding a range of technical and operational topics
- Confident with ability to challenge/respond to technical/process issues.
- Desirable
- Experience of working with engineering modelling tools (e.g. Matlab, Simulink)
- Knowledge of a programming language (e.g. C, Visual Basic, Python)
- Knowledge of and/or interest in avionics equipment
What can I expect from my working environment?
This is an office based role using display screen equipment, with some work being required in laboratories. You will be working full time hours which can often be in a demanding environment. Working to tight deadlines either on a regular or ad hoc basis may be required. As S3 is a geographically dispersed line of business, the role is likely to include travel within the UK, and possibly also abroad, to support customer meetings or demonstration activities. In some cases you will also be expected to stay overnight as part of this travel. There may also be the possibility of placements on different sites within the UK.
What's in it for me?
Leonardo value their people and we reward commitment with a competitive remuneration and flexible benefits package including:
- £26,000 starting salary
- £2,000 welcome bonus
- Accommodation Allowance (£400 p/m for 6 months)
- Free/subsidised gym membership
- 33 days holiday and flexible working arrangements
- Mentoring and financial support whilst working towards professional accreditation
- 3 performance related pay reviews within the 2 years
- Contributory pension scheme
- Private healthcare
What are you waiting for?
A career in the defence industry rewards over 162,000 people and generates a £22billion turnover. Come and be a part of a community and work with some of the most talented engineers in the UK on some of the most exciting projects around.
Don't delay – Roles will be closed as soon as they are offered! So APPLY NOW to avoid disappointment.
Remember to mention TARGETjobs when contacting employers!


text:
Revamped Aviva to hire up to 40
Aviva Investors, which was restructured four months ago and manages $469bn (€354bn) in assets, plans to hire staff and develop additional products, at a time when other wealth managers are struggling.
Greg Boal, Aviva Investors North America chief executive, said he intends to add between 20 and 40 staff in the coming months, mainly portfolio managers and analysts, as well as derivatives specialists to help manage the risk of various products.
In terms of investment strategies, Boal said the firm aimed to target investors that have become more conservative, demanding and risk averse as a result of the crisis. Strategies will include using bond portfolios with a portion of the account invested in instruments that participate in the upside of an equity market, which can be done by using options.
Boal said: "We are strong in fixed income and derivatives, and there is a tremendous opportunity for us as an organisation to leverage that and bring to market strategies with an objective to provide principal protection while participating in the upside of the equity markets."
Aviva Investors combines entities that were under the overall Aviva umbrella. In September, they were merged into one entity with six arms: Aviva Investors North America, Aviva Investors Asia; Aviva Investors Europe; Aviva Investors UK; Aviva Investors real estate; and Aviva Investors global investors solutions.


text:
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United States District Court, E.D. California
May 23, 2014
RICHARD NUWINTORE, Plaintiff,v.UNITED STATES OF AMERICA and MANAGEMENT & TRAINING CORPORATION, Defendants.
(Docs. 30, 47)
ANTHONY W. ISHII, Senior District Judge.
Defendant United States of America ("the Government") seeks dismissal of claims brought by Plaintiff Richard Nuwintore ("Plaintiff") against the Government. (Doc. 30.) On March 18, 2014, the Magistrate Judge found the Court lacks subject matter jurisdiction because no cause of action under the Federal Tort Claims Act exists under 18 U.S.C. § 4042. In addition, the Magistrate Judge determined the independent contractor exception to the Federal Tort Claims Act barred Plaintiff's claims for negligence because the Government delegated the duties of inmate orientation, health services, and maintenance-among other responsibilities-to Management & Training Corporation ("MTC"), and retention of some control over Taft Correctional Institution did not rise to the level of controlling or supervising the day-to-day operations. Accordingly, the Magistrate Judge recommended Plaintiff's claims against the Government be dismissed pursuant to Rule 12(b)(1) of the Federal Rules of Civil Procedure. (Doc. 47.)
Plaintiff filed timely objections to the Magistrate Judge's Findings and Recommendations on March 27, 2014 (Doc. 48). Plaintiff contends the Magistrate Judge erred in finding the Court lacks subject matter jurisdiction, arguing there is a private cause of action under 18 U.S.C § 4042, and the independent contractor exception to the Federal Tort Claims Act does not bar his claims against the United States. (Id. at 2-8.) Further, Plaintiff asserts that "[u]nder California law, the direct allegations against the USA in Plaintiff's First Amended Complaint establish liability that is separate and distinct from that of any independent contractor theory." (Id. at 8.)
Significantly, the Government made a factual challenge against Plaintiff's claims under Fed.R.Civ.P. 12(b)(1). With such a challenge, "[n]o presumptive truthfulness attaches to plaintiff's allegations." Thornhill Pub. Co. v. General Tel. & Elec. Corp. , 594 F.2d 730, 734 (1979); see also Safe Air for Everyone v. Meyer , 373 F.3d 1035, 1038 (9th Cir. 2004) ("in a factual attack, the challenger disputes the truth of the allegations that, by themselves, would otherwise invoke federal jurisdiction"). Given the nature of a factual attack, the Court has the authority to "review any evidence, such as affidavits and testimony" presented by the parties. McCarthy v. United States , 850 F.2d 558, 560 (9th Cir. 1988), cert. denied, 489 U.S. 1052 (1989).
Although Plaintiff argues that he alleged "the USA negligently or wrongfully failed to provide suitable quarters and provide for the protection, safekeeping, care, and subsistence of Plaintiff by failing to warn Plaintiff about the dangers and risks associated with Valley Fever and failing to make structural changes to Taft CI... and by being negligent in its study, formulation, and implementation of a response to the Valley Fever epidemic at Taft CI" (Doc. 48 at 9), the allegations are insufficient. As the Magistrate Judge found, the Government delegated responsibilities "related to health services and management" of Taft Correctional Institution to MTC. (See Doc. 47 at 9.) Such responsibilities included maintenance, sanitation, health services, health education, and inmate orientation. (Id. at 9-11, citing Straus Decl. ¶¶ 18, 38, 41-43; Harvey Decl. ¶¶ 1, 27-29, 37.) Consequently, the Government retained little control over the facility, and MTC acted as an independent contractor. This conclusions is consistent with this Court's prior determination in Edison v. USA, Case No. 1:12-cv-2026-AWI-JLT, 2013 U.S. Dist. LEXIS 128503 (E.D. Cal. Sept. 9, 2013). Finally, as the Magistrate Judge determined, "standing alone, no cause of action under the FTCA exists under § 4042." (Doc. 47 at 7, citing United Scottish Ins. Co. v. U.S. , 614 F.2d 188, 197 (1979)).
Having carefully reviewed the record, the Court finds the Findings and Recommendations are supported by the record and by proper analysis. Accordingly, IT IS HEREBY ORDERED:
1. The Findings and Recommendations filed March 18, 2014 (Doc. 47) are ADOPTED IN FULL; and
2. The Government's motion to dismiss (Doc. 30) is GRANTED; and
3. Plaintiff's First and Third Causes of Action are DISMISSED.
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LRC, Inc. About Us


text: We've lived in TC for 10 years and have tried EVERY pizza place, and Thatsa rocks the house. We've never had a bad pizza at any of their locations and the service had always been great. We tell all of our friends about this TC original, give it a try.


text:
09 Oct 2012Real heroes never give up!
After having her dreams dashed a stones throw from France by Fog, Fionnuala Walsh comes back and makes her dream come true.
When things don't go to plan, you have two choices: give up or try again. It's what one does with setbacks that makes us who we are, and this is where true heroes shine through.
This morning Fionnuala Walsh slipped into the cold Channel waters to complete her dream, which was dashed two months earlier by fog, a couple of hundred metres from French sand. She kept the swim low profile, but swam a brilliant swim today, and finished in 15 hours and 26 minutes.
Fionnuala is an example to us all. We all congratualte you wholeheartedly.
Sandettie Lightship Observations
11am, 4th December 2016
Water: 51.1 °F (10.6 °C)
Air: 39.4 °F (4.1 °C)
Wind Speed: 18.0 kn (33.3 km/h)
Wind Direction: E (100°)
Best of luck to Pip Barry who started his swim from Samphire Hoe at 23:02 with Neil Streeter on Suva2 months ago


text: ok i got my friends 2g iphone to jailbreak and unlock for t-mobile. problem is he doesnt have a at&t sim card so i cant get passed the screen that asks for the sim card. i have a t-mobile sim card. is there anyway to unlock and jailbreak the iphone without a working at&t sim card?


text:
Parking Games
Parking Training
Can you park your car in these spots? You'll have to use your reversing skills to avoid hitting anything!
Franky Valet Parking
Things are really busy down at the parking lot this afternoon and Franky could really use your help. Join him while he finds some spaces for all of these sports cars, vans, golf carts and more in this mobile game.
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You've found the perfect parking space...if only you could squeeze into it!
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Find a parking place and park your car carefully!
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Crazy about car-parking games? Then go bananas docking boats!
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Choose your instructor and practice your driving skills online!
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Take your parking skills to the next level in this brand new 3D parking game, Bus Parking 3D! Do your best to perfectly park that bus and to avoid obstacles along the way.
Played 12640 times
Can you reverse park your bus into each of the bays? It's not easy when you have such a long vehicle
Played 1555 times
Parking these sports cars isn't nearly as easy as it looks, especially when time is running short...
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How good are you at parking? Test your car parking skills in this brand new arcade browser game, Parking Fury. Show off those cool driving moves to friends!
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Show off your driving skills with New York's finest.
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The goal in this challenging skill game is simple: park the car! Use the arrow buttons on the screen to move the car and maneuver it into the marked spot. The faster you park correctly, the higher your score will be in each level.
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Tanks are awesome, but who can maneuver these massive metal monsters?
Played 2953 times
Just how good are you at parking cars? What about parking supercars? Park expensive model cars with pleasure in Supercar City!
Played 18037 times
Things are really busy down at the parking lot this afternoon and Franky could really use your help. Join him while he finds some spaces for all of these sports cars, vans, golf carts and more in this mobile game.
Played 4813 times
Tame this monster tanker!
Played 3499 times
Someone's gotta keep the streets clean…
Played 14399 times
Fasten your seatbelts, rev your engines, and get ready to…park.
Played 27857 times
Be VERY careful…every bump or scratch comes straight out of your pay!
Played 30431 times
Anyone can drive but parking takes real skill. Can you get into these tight spots without bumping your car?
Played 5721 times
Driving this cool car out of the crowded parking lot isn't going to be easy...
Played 4154 times
Park the expensive cars of the stars in the parking lot without damaging them!
Played 1112 times
The trucks got bigger and the graphics got better in this exciting sequel, Park My Big Rig 3! How far can you get in each test?
Played 4828 times
Play 5 Nights Mega Parking for free now and drive through the daunting alleys of horror Freddy Fazbear style! Complete your missions and avoid bumping into dark and dangerous obstacles while you earn money too! Test your driving skills in just 5 nights now.
Played 9676 times
Test your car parking skills in this brand new car parking simulator, Park Your Car. Drive a variety of cars and swerve around other parked cars to get to your destination with ease.
Played 3429 times
It's time for some defensive driving—the dark vehicles are invading!
Played 3568 times
Who rules the streets of towing land? Prove that you do!
Played 18458 times
Race to the rescue; it's an emergency!
Played 2902 times
And you thought parking a car was hard! Can you get this t-rex on the right spot in her nest?
Played 1153 times
Definitely more difficult than parking your car in real life. For reals. Try not to wreck your ride.
Played 1348 times
This isn't just any regular old parking game, son.
Played 841 times
Never challenge an army tank for the last parking spot! How well can you park my tank?
Played 2493 times
Airports aren't all about planes!
Played 5690 times
Played 1796 times
Think you've got what it takes to be an ice road trucker?
Played 6838 times
Played 1589 times
From big trucks to emergency vehicles, you'll have to take the test once again to prove that you know how to park these important vehicles.
Played 1861 times
Park your car in the highlighted space without hitting another vehicle!
Played 986 times
Even F1 drivers have to start somewhere...
Played 761 times
You have 60 seconds to park your car perfectly in the parking spot.
Played 1149 times
Give this car the right touch and it'll purr like a (parked) kitten.
Played 1824 times
Hate shoveling snow? Wait til you get behind the wheel of this awesome machine. It'll change your mind!
Played 659 times
Test your parking skill and agility! You have only 80 seconds!
Played 795 times
How skilled are you at parking big trucks? Find out with fun driving tests now!
Played 816 times
These tight taxis need to fit in tight spots, and Indian guides are in need of your skills. Can you get the parking spots without slamming the other cars?
Played 1281 times
Show off your speedy parking skills!
Played 6637 times
Dart and dash through the streets of Britain's capital in your very own double-decker bus!
Rule the Parking Lot
There's nothing quite so satisfying as pulling off the perfect parking job. Put your master maneuvering on display in the dozens of parking games you'll find right here. We've got all kinds of car parking games, from valet parking games like Valet Parking 3D to horror-themed parking games like 5 Nights Mega Parking (from the Five Nights at Freddy's series), and 'toon parking fun like Vehicles, a cartoon lesson in defensive driving, to realistic 3D parking games such as Jeep Pro Parking. Practice your parking on cars you'd never want to risk scratching in real life in Parking Training, Car Thief Parking, and other games featuring luxury cars.
However, we've got plenty of ways to practice your perfect placement with bigger vehicles in our bus parking games (Bus Driver Weekdays 2), truck parking games (Heavy Duty Truck Parking), towing games (Towing Mania), and all the rest (parking doesn't get more intense than in Tank Attack). Master the forklift in Forklift Frenzy, or brave South Asian traffic in Bombay Taxi. There's also boat parking, as in Azure Bay Docking, with its glossy graphics. You can even practice your Dino Parking!
Whether you choose a truc or bus or "just" a car, you'll be doing more than playing valet for a day when you practice your parking online. You're building not only your hand-eye coordination, but especially your spatial reasoning skills while you play. (Especially if you do it in 3D!)
There's a spot for you somewhere here. Just find it and pull in.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Dec 26, 1995
|Filing date
|May 31, 1994
|Priority date
|May 31, 1994
|Fee status
|Publication number
|Stephen Fry
|Original Assignee
|Fry; Stephen
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (24), Non-Patent Citations (1), Referenced by (48), Classifications (6), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
Relatively large numbers of persons suffer from a variety of respiratory diseases. Three main respiratory diseases are bronchitis, emphysema and asthma. In two of these, the airways of the lungs become constricted and breathing becomes labored or difficult. To some extent, the conditions caused by bronchitis and asthma are reversible. Inhaled medications have been developed to provide fairly rapid relief from the symptoms of bronchitis, emphysema and asthma. These medications typically are dispensed from hand-held, metered multi-dose inhalers, which deliver medications for dilating the airways of the lungs and/or for reducing the swelling of inflammatory allergic tissues of the airways. Such medications are sold under a number of different brand names.
Most hand-held inhalers include a pressurized aerosol container for the medication. The container then has a metered pressure-actuated outlet on it, which is coupled with an atomizer nozzle. The atomizer nozzle, in turn, directs the atomized medication spray into a mouthpiece, from which the medication is sprayed into the mouth of the user for inhalation into the lungs.
Almost all of the hand-held dispensers utilize the same operating principle described above, and are subject to the same limitations. A primary problem is that the medication is sprayed into the mouthpiece at a relatively high velocity and in a fairly narrow concentrated stream. A major percentage of the medication, which is sprayed through such a dispenser, is deposited in the mouth, throat and trachea of the user. Eventually, this deposited medication is swallowed; but such medication deposits do not reach the lungs where the medication is required. Consequently such deposited medication serves no medical purpose to the patient, and may additionally result in undesirable side effects and expense.
Since only a relatively small percentage of the overall medication which is released in a conventional hand-held, metered dose inhaler is applied to the airways and the lungs, more frequent application of medication is required. This, in turn, compounds the undesirable side effects of the deposited medication mentioned above. These problems are particularly aggravated for children and the elderly, who may have difficulty in coordinating the release of the medication and inhalation for most effective use.
Efforts have been made to improve the effectiveness of metered dose inhalers by providing a spacer between the standard mouthpiece of the inhaler, as sold, and the mouth of a user. Such devices are shown in the U.S. patents to Zoltan U.S. Pat. No. 4,926,852 and Walstrom U.S. Pat. No. 5,178,138. Both of these patents are directed to delivery devices in which a metered dose inhaler canister itself is inserted into a receptacle, which causes the dose to be directed away from the mouth of the user into a chamber, from which the aerosol spray is withdrawn by the user in a direction opposite to the direction the dosage is sprayed into the chamber.
The structure disclosed in the Zoltan patent is the simpler structure of these two delivery devices. In Zoltan, to permit air to be drawn through the spacer and out through the mouthpiece, air inlets are provided in the end of the spacer opposite from the end in which the medication is admitted. This is done by a series of small perforations and by means of a generally truncated cone, which helps to baffle the sprayed agent and to mix the agent with air which is admitted into the chamber when a patient withdraws air from the mouthpiece. In both of these devices, the medication canister itself is removed from the remainder of the inhaler devices, which are normally sold as a unit with the canisters. The devices of both Walstrom and Zoltan are relatively complex in configuration, and require incorporation of an atomizer nozzle as part of their construction. Thus, the atomizer nozzle which normally is supplied with the mouthpiece of the metered dose inhaler is wasted or discarded.
Two other types of spacers, which do not require an atomizer nozzle and which operate in line with the conventional mouthpiece of a standard metered dose inhaler, are described in the U.S. Pat. Nos. 4,470,412 and 4,953,545. The devices of both of these patents operate in a similar manner; although the one disclosed in U.S. Pat. No. 4,953,545 is of a simpler configuration than the device disclosed in the '412 patent. The devices of both of these patents are in the form of elongated cylindrical chambers. In patent '545 the device is simply a hollow canister; while the device of patent No. '412 includes additional features, such as a filter and a whistle in the multiple part assembly. To accommodate the mouthpiece end of different types or shapes of dispensers, both of these devices have the inlet end closed with a resilient plastic material having an aperture in the center of it. The material of the aperture is made sufficiently soft to stretch and conform around the shape of different inhaler mouthpieces. Consequently, in constructing the devices of both of these patents, the provision of the resilient aperture for receiving the various shaped mouthpieces means that this portion of the device must be made of a different material from the more rigid canister forming the main body of the spacer. As a consequence, this part needs to be separately manufactured and installed. This results in increased manufacturing costs. In addition, the resiliency of the aperture end of these devices permits misalignment of the mouthpiece, which could direct medication onto the wall of the spacer instead of into the center of the spacer chamber. This would waste the medication.
Another spacer for metered dose inhalers is disclosed in "Advances in Therapy", Vol. 10, No. 5, Sept/Oct 1993, on Page 209. The device disclosed in this article is a generally circular shaped housing which accommodates a pressurized aerosol canister at one side. The aerosol canister or dispenser must be removed from the atomizer and mouthpiece with which it normally is sold, and inserted into the spacer device. As a consequence, the spacer requires the inclusion of an atomizer in it. This nozzle is inserted between two polypropylene shells which, in turn, shape the round expansion chamber. Upon actuation and prior to inspiration from a mouthpiece opening opposite the diffuser nozzle, the emitted particulate stream is forced into a spiral. The expansion chamber creates a whirling flow of expelled particles, which are intended to remain suspended long enough to expend their kinetic energy.
Other spacers, specifically directed to a particular type of device with which they are used, are disclosed in the U.S. patents to Hansen U.S. Pat. No. 3,994,521; Lehmbeck U.S. Pat. No. 4,253,468; and Tritle U.S. Pat. No. 5,203,323. None of the devices disclosed in these three patents are directed to any type of "universal" accommodation for the mouthpiece portion of an otherwise standard inhaler to accommodate different shapes of mouthpieces. All of these devices are relatively complex in configuration.
It is desirable to provide an inhaler spacer which is capable of use with different shaped mouthpiece portions of commercial, standard inhalers, which is simple in configuration, compact easy to use, and relatively inexpensive.
It is an object of this invention to provide an improved spacer for medication delivery devices.
It is another object of this invention to provide a universal spacer for aerosol inhalers.
It is an additional object of this invention to provide an improved spacer for use with metered dose inhalers having different mouthpiece shapes.
It is a further object of this invention to provide an improved spacer for an aerosol metered dose inhaler, which is of simple construction, compact is easy to use, and is easy to clean.
In accordance with a preferred embodiment of this invention, a medication delivery device includes an elongated chamber. This chamber has an open inlet end and an open outlet end, with the outlet end being shaped to accommodate a human mouth. The open inlet end of the chamber has a substantially circular opening in it. This circular opening has a predetermined diameter and a predetermined depth. The circular opening also includes opposed relief offsets on opposite sides to accommodate medication dispensers having outlets with non-circular cross-sectional shapes, as well as circular cross-sectional shapes.
FIG. 1 is a front perspective view of a preferred embodiment of the invention;
FIG. 2 is a cross-sectional view taken along the line 2--2 of FIG. 1;
FIG. 3 is an enlarged perspective view of a portion of the embodiment shown in FIGS. 1 and 2; and
FIGS. 4, 5, 6 and 7 are end views of the portion shown in FIG. 3 illustrating use with aerosol delivery devices having different mouthpiece configurations.
Reference now should be made to the drawing, in which the same reference numbers are used throughout the different figures to designate the same components. FIG. 1 is a front perspective view of a spacer 20, in accordance with a preferred embodiment of this invention. The spacer 20 is used with a metered dose inhaler 10, which is depicted in dotted lines. The dispenser 20 has an inwardly turned right-hand outlet end with a circular opening 21 in it. The outer diameter of the spacer 20 is approximately one and one-fourth inches; and the diameter of the opening 21 is approximately one-half inch. This permits the opening 21 readily to accommodate a human mouth for inhaling aerosol medication located within the body of the spacer 20. The overall length of the spacer 20 is approximately three and one-fourth inches for a typical commercial application.
As illustrated in FIG. 2, the spacer 20 also is open at its left-hand or inlet end to accommodate a separate inlet end cap 25, which is inserted into the left-hand open end of the cylindrical spacer 20 with a friction fit. An outwardly directed flange 26 limits the extent of insertion of the inlet end cap 25 into the spacer, as illustrated in FIG. 2. Also as is most readily apparent from an examination of FIGS. 2 and 3, the end cap 25/26 has a circular opening 24 extending through it. This opening has a diameter which is less than the internal diameter of the cylinder 20 by the amount of the wall thickness of the cap 25, which extends into the hollow elongated cylindrical chamber 20. The circular opening 24 has its center located on the central longitudinal axis of the cylindrical chamber 20.
As shown most clearly in FIGS. 3 through 7, the circular opening 24 is shaped to accommodate the external diameter of a standard circular mouthpiece 11 (as shown in FIGS. 1 and 5) of a popular brand of metered dose inhaler currently available on the market. When the mouthpiece end 11 of the inhaler is inserted into the inlet opening 24, a friction fit between the inner wall of the circular opening 24 with the outer wall of the mouthpiece portion 11 takes place. This friction fit causes the mouthpiece 11 of the inhaler to be centered on the axis of the chamber 20. In this position, the metered dose inhaler 10/11 then may be used to dispel a metered dose of inhalant through the spray nozzle included in the delivery system of the metered dose inhaler 10/11. The length of the chamber 20 is selected to permit the particles of medication to be mixed with air drawn into the chamber when the used inhales through the opening 21, such air being pulled around the exterior of the mouthpiece 11 through slight differences in the opening 24 and the outer diameter of the circular mouthpiece 11. This causes the size of the particles released at the mouthpiece or outlet end 21 of the chamber 20 to be significantly reduced in size from those released at the inlet end 25/26; so that there is an increased potential that the medication will be carried into the airways and lungs of the user, reducing loss of medication by impaction on the inner walls of the spacer 20 and the mouth and tongue of the user.
The chamber 20 and the inlet end cap 25/26 preferably are made of rigid clear plastic material, such as polypropylene or the like. As illustrated in FIG. 2, these parts are shown as made in two portions, namely the cylindrical chamber 20 with the mouthpiece or outlet end 21, and the inlet end cap 25/26. The entire assembly, however, could be manufactured as a single integral unit, if desired. Whether the device is made of two parts, as shown in FIG. 2, or is made in one piece as an integral unit, cleaning is greatly facilitated. There are no soft surfaces or sharp corners where unused medication or other materials can become lodged. In addition, because of the shape and types of materials which are employed, it is easy to clean the spacer in a dishwasher, if desired. It is important for the spacer to be easily cleaned; so that reuse of the spacer is possible without exposing the user to bacterial and viral infections which may possibly breed in a spacer if it is not regularly cleaned. By making the spacer easy to clean, the likelihood that it will be cleaned between uses is greatly increased.
As illustrated in FIGS. 4, 6 and 7, other common metered dose inhaler dispensers currently on the market employ mouthpiece end configurations which are not the full circle 11, which has been illustrated in FIG. 5 and described above. Three other shapes, 14, 16 and 18, are currently in common use. To accommodate these other shapes, the inlet end 25/26 of the device shown in FIGS. 1 through 3 is provided with a pair of spaced relief areas, generally in the form of substantially V-shaped notches or indentations located on opposite sides of the circular opening 24.
As illustrated in FIGS. 3 through 7, these relief areas comprise an area consisting of two portions 28A and 28B on the right-hand side (as viewed in all of FIGS. 3 through 7) and a corresponding relief area 29A/29B on the left-hand side (again, as shown in all of FIGS. 3 through 7). These relief areas extend approximately half way into the full depth of the circular opening 24 in the end cap 25/26, as shown most clearly in FIGS. 2 and 3. As a consequence, when the flattened oval mouthpiece 14 of a dispenser such as used on the TILADE� (neocromil sodium) inhaler is used, the pointed edges of the somewhat flattened oval shape of the mouthpiece fit into the intersection points of the two relief areas 28A/28B and 29A/29B, as illustrated in FIG. 4. The opposing corners of the flattened oval mouthpiece 14 then rest against the shoulder formed by the remaining unrelieved portion of the circular opening 24 to frictionally hold the mouthpiece 14 centered in place in the end cap 25/26.
Similarly, another generally oval shaped mouthpiece end, with straight edges on each side of the oval, such as the mouthpiece 16 used in the ATROVENT� (ipratropium bromide) inhaler has exterior dimensions such that the mouthpiece 16 may be fully extended into the opening 24, with the corners or edges of the mouthpiece 16 frictionally engaging the circular portion 24 of the spacer to permit the use of an Atrovent� metered dose inhaler. The rigid opening 24 centers the mouthpiece 16 on the axis of the chamber 20. As is readily apparent from an examination of both FIGS. 4 and 6, when either of the TILADE� or ATROVENT� inhalers are used, air is drawn into the chamber 20 from around the mouthpiece 14 or 16 to mix with the medication as the user inhales through the opening 21 of the spacer.
Another type of mouthpiece, which is similar in overall shape to the one described above in conjunction with FIG. 6, is employed by the PROVENTIL� (albuterol) aerosol metered dose inhaler. The PROVENTIL� mouthpiece 18 is shown in FIG. 7, and is generally of the same overall shape as the mouthpiece 16 of the Atrovent� inhaler, but is somewhat larger in size; so that it fits into the relief areas 28A/28B and 29A/29B, as shown in FIG. 7, to abut against the shoulder formed by these relief areas with the inner part of the circular opening 24 illustrated in FIG. 3. Once again, air is drawn into the chamber 20 by a person inhaling through the opening 21 as the aerosol medication is dispensed into the chamber in the manner described above.
It has been found that by configuring the end cap 25/26 with the relief areas 28A/28B and 29A/29B as described above, all of the different commercially available metered dose inhalers, such as the ones described above, may be universally used with the spacer 20. Since no flexible plastic material is required in the construction of the device, the same rigid polypropylene plastic is used for all parts of the spacer, which facilitates manufacture, assembly and cleaning of the device throughout its use. A typical inside diameter of the circular opening 24 is 15/16 inches, with the distance between the inner points of the V-shaped bottoms of the relief areas 28A/28B and 29A/29B being 11/16 inches to frictionally accommodate the TILADE� dispenser. The other dispenser mouthpieces 16 and 18, which have been shown in conjunction with FIGS. 6 and 7, are accommodated by these dimensions. It should be noted that all of the dispensers have relatively rigid mouthpieces, but are made of plastic which has some resilience in it; so that the friction fits which have been described above may be effected.
The foregoing description of the preferred embodiment of the invention is to be considered as illustrative and not as limiting. Various changes and modifications will occur to those skilled in the art for performing substantially the same function, in substantially the same way, to achieve substantially the same result, without departing from the true scope of the invention as defined in the appended claims.
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Effective date: 19991226


text:
Johannes Kepler will fire its engines twice to descend from orbit
The European Space Agency has announced that Europe's Johannes Kepler ATV cargo ferry, built by Airbus Defence and Space, undocked from the International Space Station yesterday at 14:46:30 GMT (16:46:30 CEST). The craft is now leaving the orbital outpost far behind and will end its mission this evening as a shooting star over the Pacific Ocean.
Johannes Kepler will fire its engines twice to descend from orbit. The first burn, at 17:07 GMT (19:07 CEST), will drop it towards Earth. The second burn, at 20:52 GMT (22:52 CEST), will direct it precisely towards its South Pacific target.
ATV-CC in Toulouse seen just before the ATV-2 undocked from the ISS. (© ESA - J. Makinen)
Under contract to the European Space Agency (ESA), Airbus Defence and Space is industrial prime contractor for the ATV.
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Flying colours for the ATV Johannes Kepler mission