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FREE SHIPPING* on orders of $59 or more. Ends at 11:59PM 12/10/16.
FREE SHIPPING* on orders of $59 or more. Ends at 11:59PM 12/10/16.
Your coupon will be applied to the highest regular-price, eligible item in your cart.
Offer good for one item at regular price only. Limit one coupon per customer per day. Must present coupon at time of purchase. Offer is not valid with any other coupon, discount or previous purchase. One cut or one bolt of fabric or trim "by the yard" equals one item. Online fabric & trim discount is limited to 10 yards, single cut. Excludes Heidi Swapp™ Minc.™ Foil Applicator, CRICUT® products, Gemini Machine™ Crafters Companion, Silhouette CAMEO® Machine, candy & snack products, gum & mints, helium tanks, gift cards, custom orders, special orders, labor, rentals or class fees. Cash Value 1/10¢.
Make a statement with on-trend decor pieces.
The makings of holiday memories start here.
Fabric for your DIYs - stuffable and otherwise.
Unwrap happiness with papercrafted goodies.
Greet the season with foliage and flowers.
Everything for holiday baking and party making.
Get the supplies every artist is pining for.
Cozy on up to all sorts of needle art lovelies.
Put the finishing touches on Christmas.
Because handmade is what's in.
Time to match accessories to your personality.
Use these 7mm Silver Metal Plated Plastic Floral Spacers to create unique handmade jewelry for yourself, your friends, and your family! These fun plastic rings feature a silver metal plating and a flower shape. Pair them with coordinating pendants, charms, beads, and findings for a one-of-a-kind creation!
Package contains 40 spacers.
I love it! Add to wish list


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Автор: Ogilvie Sarah
Раздел: Cambridge University Press
|Поступление на склад 28.12.2016
Most people think of the Oxford English Dictionary (OED) as a distinctly British product. Begun in England one hundred and fifty years ago, it took over sixty years to complete and when it was finally finished in 1928 the British Prime Minister heralded it as a 'national treasure.' This book shows that the dictionary is not as 'British' as we all thought. The linguist and lexicographer, Sarah Ogilvie, combines her insider knowledge and experience with impeccable research to show rather that the OED is an international product in both its content and its making. She examines the policies and practices of the various editors, applies qualitative and quantitative analysis, and finds new OED archival materials in the form of letters, reports and proofs. She demonstrates that the OED, in its use of readers from all over the world and its coverage of World English, was in fact a global text.
Цена 19 480 тг. за 1 штКоличество

subset: commoncrawl


text: Home Gallery Video Fox Sports Coach's Birthday Fox Sports: Coach's Birthday Published on Jun 05, 2001 Editor's Pick Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateJun 05, 2001Client:Fox SportsAgency:Wieden + Kennedy Portland Latest Creativity News on Ad Age Why Are Verizon Execs Starring in Sprint's New Ad? How Storytelling Training Helped Georgia-Pacific Build Sales Without Boosting Budgets U.N. Staffers Petition to Recall Wonder Woman as Ambassador to Women Advertisement Ad Age Reports Partner White Paper 7 Tips for Keeping Your Creative Team Inspired Beat the creative slump with this informative guide which includes great advice on how to keep your team positive, productive and inspired. Brought to you by Shutterstock Premier. Learn more Related work Fox Sports: Pool Pereira & O'Dell Fox Sports: Pinata Pereira & O'Dell Fox Sports: Fox Sports: Sorry For All the Football Pereira & O'Dell Want to see your work in our gallery? Submit now


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Full Time: Concord Rangers 1-3 Diamonds. Fantastic. Brilliant. Heroic. Pick your choice of superlatives
5 years Never Forgotten #theresonlyonedaleroberts
Every Diamonds player, every fan and every member of staff can be proud of today and the season as a whole #lovethisclub #wearetogether
So it will be a final against @KTFCOfficial on 12th April at sixfields


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"This is a wonderful dessert for any time of the year. You can use frozen or fresh fruits!"
- Yield
- 5 servings
- 1 (16 ounce) bag of frozen berries of your choice OR 4 cups of fresh berries of your choice
- 1/4 teaspoon of salt, to taste
- 1/4 teaspoon of pepper, to taste
- 2 tablespoons balsamic vinegar
- 1 cup flour
- 1 cup rolled oats
- 1/4 cup brown sugar
- 1/4 teaspoon salt
- 1/4 cup butter
- 1/2 cup chopped walnuts or almonds
- 1. In a glass baking dish or deep pie dish, add fruit and sprinkle with salt, pepper, and balsamic vinegar (This is a secret ingredient and will make the flavor of your fruit pop!) 2. In a separate bowl combine flour, rolled oats, brown sugar, salt, butter. Mix with fork until it forms a crumble consistency. 3. Sprinkle nuts over top of fruit. 4. Dot with butter. 5. Bake at 375 for 20-25 minutes until crumble starts to lightly brown and crisp. May be served warm or cold. 6. Add whipped cream or ice cream for a special yum!
Nutritional Info
- Calories338
- Carbohydrates52 g(17%)
- Fat13 g(19%)
- Protein6 g(12%)
- Saturated Fat6 g(31%)
- Sodium240 mg(10%)
- Polyunsaturated Fat2 g
- Fiber5 g(19%)
- Monounsaturated Fat3 g
- Cholesterol24 mg(8%)


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Check in from 2:00 PM / Check out prior to 11:00 AM
Kallangur Motel: Find photos, reviews, information, amenities and compare prices for 2 stars hotels in Kallangur, Australia.
Located in Kallangur, Kallangur Motel is within a 30-minute drive of Brisbane Airport and offers a swimming pool.
Hotel description
The rooms at the motel feature a refrigerator, a spa bath and tea and coffee making facilities. A shower, a microwave and cable/satellite channels are also provided.
For those guests who enjoy exploring local restaurants and cafés, there is a large variety within walking distance. It also provides an ideal base to explore Murrumba Downs and Caboolture.
Hotel features
Air Conditioned, Refrigerator, Cable / Satellite TV, Coffee / Tea Maker, Microwave, TV, DVD Player, Shower
Swimming pool
Availability and Prices
Booking Site
Room Type
Per room
Per night
Per night
Users who viewed Kallangur Motel also viewed these 2 stars Kallangur hotels:
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Nearest hotels
- Homestay In Dakabin Brisbane
1.6 miles
- Homestay In North Lakes Brisbane
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- Liberty Circuit Executive Home
2.2 miles


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Auction House Details
William H. Bunch Auctions and Appraisals
|Auction House Name
|William H. Bunch Auctions and Appraisals
|Site URL
|About Us
|We offer prompt and discreet consultations in the evaluation and sale of antiques, fine art, and appreciable personal property.

Specialty and general auctions conducted year round at our location or yours. Sales promoted world wide through national & international trade journals, extensive direct mailings, illustrated catalogs on the world wide web.

Appraisals prepared for the functions of:

Estate Taxation
Division of Property
Liquidation
Donation
Insurance
Auction Estimates
All appraisals comply with the "Uniform Standards Of Professional Appraisal Practice" as authorized by congress and adhered to by all major professional appraisal organizations in North America.

Staffed with specialists in All areas including:

18th to 20th Furniture
Porcelain
Art Glass
Cut and Pattern Glass
Pottery
Beer Steins
Antique Guns, Swords, Armor
Civil War Relics
Antique Clocks, Music Boxes, & Phonographs
Silver Of All Periods
Jewelry
Toys & Dolls
Antique Banks
Oriental Rugs
Fine Art Including Oil Paintings, Watercolors, & Works On Paper
Books & Manuscripts
Other Antiques & Collectibles
|Who do I contact if I have questions?
|Chadds Ford, PA
|United States
|Contact Number
|(610) 558-1800
|Buyer's Fee
|20% discounted to 17% by cash or a good check. Internet bidders additional 3%
|Consigner's Fee


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26 July 2016
Foreign private equity investors has helped shore up the Israel dealmaking environment amid a year-on-year drop in total PE investment in the first half of 2016.
Read full story
9 May 2016
Private equity investments in Israel took another dive in the first quarter of 2016, hitting its lowest dollar value for a quarter since the middle of 2014, new research shows.
9 November 2015
Israeli private equity dealmaking dropped to $419m in the third quarter of the year, more than 40 per cent below the five-year quarterly average.
11 September 2015
Israeli private equity performance hit a quarterly record in Q2 of this year, with 29 deals made amounting to $1.67bn in capital, new research shows.
11 May 2015
The amount of capital private equity firms invested in Israeli deals dropped more than 50 per cent quarter-on-quarter in the first three months of 2015, new research shows.
22 January 2015
High tech capital raising in Israel hit an all-time high in 2014 after $3.4bn was invested in 688 companies.
25 November 2014
Israeli private equity dealmaking has slumped in value by more than a quarter across the first nine months of the year according to a new report from the IVC Research Center.
21 July 2014
Israeli high-tech companies raised the highest quarterly amount of funding since 2000 in the second quarter of 2014, pulling in $930m from investors.
26 June 2014
Israeli funds dominated private equity investment activity in the first quarter of this year, according to KPMG.
19 June 2014
Even though investments in Israeli high-tech companies dropped in the first quarter, the volume was still "exceptionally high," according to a report from IVC and KPMG.
The outlook for infrastructure private equity and venture industry - from the latest AltAssets' LP-GP Forum
Pantheon channels $33bn of LP capital to GPs through funds of funds, co-mingled funds, secondaries and co-investments. Its business is built on delivering outperformance over 25-plus years. Now the firm is ready to pull the trigger on the vast DC market
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AltAssets is registered as a trademark of Investor Networks Limited (06695690).Registered Office: WeWork 4001, 1 Fore Street, London, EC2Y 5EJContent is © AltAssets 2000-2016


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Did ARJUN KAPOOR say no to 'SULTAN'?1,079 views
Salman Khan and Anushka Sharma starrer, 'Sultan' has been breaking records at the box office and the lead cast is being praised by one and all for their splendid performance in the film.
Salman Khan's wrestler avatar has garnered him huge accolades and not many know that Salman's role from the film was earlier offered to some other actor. Yes, according to reports, the role was earlier offered to Arjun Kapoor by director Ali Abbas Zafar. Ali had worked with Arjun in 'Gunday' and wanted to rope him in for the film. Arjun, on the other hand, wasn't keen on the subject of wrestling.
Also Read: Here's what ANUSHKA SHARMA said on 'SULTAN' being called a sexist
But, if this is true, then Arjun surely has lost a lot professionally.
News Source Bollywood Bubble & IMDB


text: Baby Born From 20-Year-Old Frozen EmbryoMara Hvistendahl - Popular Science10/12/10 8:41pmFiled to: EvolutionbiologyReproductionScienceRepublishedtweet93EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Cryopreservation was once the domain of sci-fi novels and B-rate movies. (Think Encino Man.) But it's increasingly real, as the recent birth of a healthy boy from a frozen embryo created 20 years earlier shows. Advertisement The birth, which is reported in a study in the online edition of the journal Fertility and Sterility, sets a record. Until now, no embryo frozen for this long has resulted in a live birth.The 42-year-old mother of the boy, who is not named in the study, began trying to get pregnant using IVF ten years ago. At the time, she and her husband received embryos from a heterosexual couple who had themselves undergone IVF. Advertisement That couple had anonymously donated their leftover embryos after the woman successfully gave birth. Thing was, they did so in 1990 – meaning that the boy just born to the woman in the study has a sibling out there somewhere who was conceived at the same time but is 20 years younger.Frozen embryos are something of a new ethical frontier in IVF — one that was not foreseen back in 1978, when Nobel Prize in Physiology recipient Robert Edwards and colleague Patrick Steptoe announced the birth of Louise Brown, the world's first test-tube baby. Because of improved fertility drugs and lab techniques, the average IVF cycle now yields more embryos than it once did. Many of those end up in the freezer, where they keep remarkably well.But the ethical and practical implications of keeping potential humans on ice are now becoming abundantly clear. Increasingly, divorced couples fight over frozen embryos. And the preservation of genetic material – embryos, eggs, and sperm — created by biological parents who may be well beyond their reproductive years gives others pause. In 2007, a mother froze eggs for use by her daughter, then seven years old, who was born with a condition that could make her infertile. If the daughter someday uses the embryos, she will give birth to her half-brother or half-sister. Sponsored And then there is the time lapse between conception and birth in this latest news item. Previously, the record-holder for longest time in the freezer was a baby born from an embryo that had been frozen for 13 years.Mara Hvistendahl is writing Unnatural Selection, a book on reproductive technology, sex selection, and gender imbalance. Popular Science is your wormhole to the future. Reporting on what's new and what's next in science and technology, we deliver the future now.Gear from Kinja DealsThe New 3DS Doesn't Include a Power Adapter. Get This Instead.The Best Gaming Chair For Your DeskIf You Think You Can Handle It, the AmazonBasics Bocce Ball Set Is Cheaper Than EverReply93 repliesLeave a reply


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WGSN Products
WGSN Trend Minute: Key beauty looks from Paris Fashion Week S/S 16
Eyes were blue and graphic and hair was undone and flyaway. WGSN Beauty Editor Theresa Yee calls out the need-to-know trends in 60 seconds
55 sec
From bright eyes to graphic liner to a resurgence in blue shadow, Paris Fashion Week proved there are lots of popping looks to master ahead of Spring/Summer 2016. Meanwhile, when it came to hair, the less done the better.
Find out about these emerging looks and more (you have to see the standout nails from the season…) with Beauty Editor Theresa Yee in WGSN Trend Minute.
LOVE TREND MINUTE? Subscribe to WGSN's YouTube and see our latest videos first.
NEED INSPIRATION? WGSN publishes 350 in-depth reports each month. That's a seriously awe-inspiring amount of inspiration. Join WGSN.


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Shamsher comes out to the place where padmini stays in a taxi after getting down from the flight.he sits inside the house and examines the sudden happiness in padmini's face.he try to explain her that it must be madhoo's child and damad .padmini gets shocked on hearing about her grand daughter and her husband but still she is sure that the person whom she saw is her daughter and RK.shamsher tries to change the topic asks about Gowtham while they hear a knock at the door.padmini goes to see.Madhu argues with RK for giving 1000 rupees to the person who guided them and blames him to be like a charity person while the door opens.padmini gets shocked to see madhoo while madhoo doesn't feel the reality.she calls RK.RK was seeing the nearby places and praises the beauty
He also turns and almost shouts "sasu ma"
Deepika smiles seeing him taking his hand when she sees him with surprise and sees his car parked outside ,she thinks something Gowtham asks her sorry for holding her hands ,deepika asks him to take her for a long drive. He agrees after a minute of confusion.they gets into the car and there remains silent for a moment.
Deepika:mmmm then sir ?
Gowtham:nothing special.
Deepika:my chacha and chachi saw your granny in market .
(Applies a sudden brake )
Deepika:why ,what happened ?
Gowtham(so that is not Madhu and raj):nothing,I was actually quite surprised so only.
Deepika:mmmm ok.drive the car
Gowtham:yeah sure(resumes driving )
Deepika tries to adjusts the AC while Gowtham helps her he hold her hand,the radio switch's by mistake and "tu muskura "songs plays .both of them moves away from each other.
Deepika:ac was not so so only.
Gowtham:I also just tried to help.
Deepika:how is ur business ?
Gowtham:yeah so nice.I am getting a new deal .
Deepika:what about the treat ?
Gowtham:sure I will give you so soon.
Deepika:mmmm ok.
Gowtham stops the car in front of a dhaba and asks her to get down. She comes out with a confusion and both sits in a seat far away from others .there remains a silence.
Ayesha shouts at her mom for supporting Madhu after all the incidents that happened in the life of them.her mother asks her not to shout like a mad and goes from there angrily.ayesha sits crying thinking about the last rites of her brother.she heard the bell sound and goes to see the person.Sunny stands there with bittoji in the entrance.she gets shocked on seeing him with his dad and falls on his feat.they sits in the hall and she runs inside to inform her mother who is standig angry in her room.
RK and Padmini tries to wake madhoo up who was fainted on seeing her mother there in a unexpected situation .madhoo doesn't open her eyes due to shock while shamsher comes there with cool water to sprink in her face.madhoo wakes after a long try and opens her eyes ,she gets so much tears on seeing her mother.she says"RK,my mom ".RK also nods yes and helps her to sit there comfortably. Shamsher remembers the day he hold the small cute baby in his hand and gets tears.RK sees Trishna's photo Garlanded and gets shocked on hearing her death news.padmini sits near madhoo and hugs her cryingly.
Madhu thinks of the incidents in morning with a blush in her face,she sees the files which are left pending and asks the peon about gowtham sir.Raj sits in the house and eats the food made by Madhu happily thinking that she may Change in sometimes .he hears a bell sound and goes to see who is on the door.and finds a young boy standing there with dirty cloths and uncombed hair.Raj opens the door .Chandru sees him with tears filled eyes and takes out something from his bag.
Aarya sits and tastes the food made by Rajini for him.he finds the food without salt and thinks to add it to the gravey before she comes but when he almost opens the salt box,she comes asking him about the taste of the food.she eagerly waits for his comment .he thinks not to hurt her and praises the taste of food.he goes from there after completing food and Rajini eats the food and her reaction changes on the taste of the food without salt.she gets tears on thinking about aarya lying for her.
Padmini doesn't tell anything about gowtham,harshavardan and makes madhoo eat by her own hand and caress her face.gowtham tries to call his nani to talk but she cuts the call before madhoo sees the name and photo which is displaying in the screen.RK sits talking with shamsher and feels something not correct in their convo.he leaves home with madhoo.he thinks of sharing it to madhoo but stops seeing her happiness. Shamsher asks padmini"why are you hiding truth ?",she sits crying.
Precap:Madhu gets call about raj being hospitalised.


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Outdoor Spa and Pool Towel Rack RDRunner,http://www.amazon.com/dp/B005H5TA2C/ref=cm_sw_r_pi_dp_ex.Bsb082XT9R5EG
DIY Pool Towel Holder - We made this stand to hang our wet pool towels to dry after swimming!
Towel racks More
Reclaimed Wood Copper Rod Double Towel Rack by NCRusticdesigns
towel rack for pool | Towel rack. Outdoor drying rack for pool towels and bathing suits.
Make the perfect outdoor towel rack out of inexpensive PVC pipes! Every pool owner needs one of these. Get the how to instructions here: http://www.ehow.com/how_5123231_build-pvc-pool-towel-rack.html?utm_source=pinterest.com&utm_medium=referral&utm_content=inline&utm_campaign=fanpage
Outdoor towel rack for pool or sprinklers
Outdoor towel rack made from a pallet!
Pallet turned poolside towel holder. Free pallet, little paint, Hobby Lobby metal accent and hooks
Galvanized tin shower!! Maybe for the attic? Towel rack is horseshoes- someday when i a) build on a 2nd bathroom or B) redo the existing bathroom


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Workshops, Conferences & Retreats
The Omega Institute offers more than 350 workshops, retreats, and conferences every year. Each one is designed to inspire, educate, and connect you to new ideas and people. From large conferences to intimate workshops to professional trainings, the diversity of our programs allows us to confidently say there is something for everyone. To make it easy for you to find what you're interested in, we have organized our workshops into six different learning paths: body, mind, and spirit; health and healing; relationships and family; creative expression; leadership and work; and sustainable living.
Upcoming Workshops
05/14/2017 to 05/19/2017
05/19/2017 to 05/21/2017
Supporting Practice & Building Community
Please call Omega at 877.944.2002 to register for this workshop.


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Boutique Homes
Home builders from Melbourne VIC, Boutique Homes build new homes, and offer competitive house and land packages. Display homes throughout Melbourne VIC are also available.
+ Recent listings in this category: Builders
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Over the past month, we here at KPI have been very honoured to work with one of Britain's leading charities; Help for Heroes. Established in 2007, Help for Heroes (H4H) raise funds to help injured servicemen and servicewomen returning from Iraq and Afghanistan.
For too long we pinned medals to the able-bodied and raised memorials to the dead whilst ignoring those who had sustained terrible injuries in the course of duty. They were the forgotten. The injuries and sacrifice can take many different forms. It is the loss of both legs and the long period learning to walk again. It is the man whose wounds are invisible; who saw too much and can forget too little. It is the young boy whose mummy won't be coming home and needs someone to tell him why.
Over the past four years, H4H have raised almost £120 million to help injured servicemen and women. They have approved grants to schemes covering all aspects of care and recovery; from the immediate aftercare of wounded soldiers who have returned home, through to ensuring that those with disabilities are not excluded from the social activities that unite current and former soldiers.
In order to make sure every pound donated goes to those who need it, H4H covers its running costs through its online merchandise store. That's where KPI comes in. Over the past few weeks, we've been running a charity SEO campaign designed to drive customers to the H4H store in the run up to Christmas. As well as press releases and article submissions, our team of link builders have been ringing around companies and organisations asking them to write a blog post, put a link on their homepage or post a link to Facebook or Twitter. We've been in touch with existing clients, large companies, and major sports clubs. We've been astounded by the level of support people have shown for the country's injured service personnel. Almost everyone we have spoken to has been enthusiastic about the cause. Whether it was a quick mention on Twitter or a link printed up in the next match's programme, we want to extend a huge thank you to everyone who gave their support to H4H and the men and women it helps. Forgotten no longer, it seems.
If you'd like to help H4H, then all you have to do is write a few lines about the charity on your website and throw in a link to any page from its website (http://www.helpforheroes.org.uk/) and online store (https://www.shop.helpforheroes.org.uk/). Alternatively, you can post a link on Facebook or Twitter (http://bit.ly/h4heroes for the shop and http://on.fb.me/h4hcharity for the website) and ask your followers to re-Tweet. If you'd like to discuss how you can help the UK's injured soldiers or want to know how we can help your charity get the most from its online presence, then drop us a line.


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Unusual open faced grilled cheese. Unusual because sandwich is grilled, cheese face down, and doesn't stick! Not heart healthy but great once in a while
- 1 slice of American or mild cheddar cheese-approx. one ounce
- 1 slice Health Nut sandwich bread
- 1-1/2 tsp salted butter
- 1-1/2 tsp mayonnaise-I prefer Dukes as it is a bit more tangy than Kraft or Hellmann's
- The metal turner is desirable when using a cast iron skillet as it slides easily between cheese and skillet without tearing or bunching up the cheese on the sandwich
- Heat skillet with butter to med. high heat being careful not to burn butter. While skillet is heating spread mayo on one side of bread. When skillet is hot place cheese on top of mayo, flip sandwich over and place in skillet cheese side down. Cook approx. 4 minutes and using a metal pancake turner gently raise one edge of sandwich to ensure cheese is browned. Once cheese is browned turn sandwich over and brown the bread side. Enjoy!
Nutritional Info
- Calories268
- Carbohydrates3 g(1%)
- Fat22 g(34%)
- Protein15 g(29%)
- Saturated Fat12 g(60%)
- Sodium415 mg(17%)
- Polyunsaturated Fat1 g
- Fiber0 g(1%)
- Monounsaturated Fat5 g
- Cholesterol63 mg(21%)


text:
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Level Experienced Job Location USA-NY-New York Travel Percentage 25% Position Type Full Time Job Shift Day Education Level 4 Year Degree Position Summary: The Director of Analytics is the business unit leader for the assigned metropolitan area(s). You will provide oversight10/11/2016 New York, NY Save This Job
at GuideSpark (View all jobs) Portland Position Description: As an amazing visual artist, you understand the power of video. You know how to creatively speak to the soul of a global brand. You know the complexities and short cuts when it comes to animation. You can provide10/9/2016 Portland, OR Save This Job
Bethesda, MD Rogers, AR Nationwide Looking for Hunters. The Global Account Director is responsible for helping to grow the business via the acquisition of net new customers. This individual is responsible for stratifying their marketplace to achieve the most effective and9/13/2016 Bethesda, MD Save This Job
Director, Product Management for CommunicationsAbout VelocifyVelocify builds tools for sales organizations, enabling sellers and managers to be dramatically more effective. We are building the most advanced sales acceleration platform and unlocking the value of CRM and Marketing11/25/2016 El Segundo, CA Save This Job
Posted: September 27th 2016 ZoomSystems is growing and has strong demand for its solutions. The ideal candidate will have a passion for driving innovations in the retail world and also possess the discipline and patience required for high-scale solution sales. The candidate12/3/2016 San Francisco, CA Save This Job
The Director of Marketing works closely with the VP of Marketing to develop all marketing, advertising, and communications initiatives, both internal and external, across multiple platforms and formats to drive customer acquisition, subscription sales, engagement, retention and11/29/2016 Westerville, OH Save This Job
WiTricity is seeking a Senior Manager/Director, Electrical Engineering to lead a team of engineers at our Watertown, MA headquarters. Reporting to Vice President of Automotive Engineering, this role will have responsibility for successful delivery of quality products on-time and11/24/2016 Austin, TX Save This Job
Department: Clinical Research Job Location: South San Francisco Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators as potential treatments for debilitating diseases in which muscle11/21/2016 South San Francisco, CA Save This Job
at DataXu (View all jobs) Boston DataXu?s vision is to make marketing better using data science. The world?s top brands and agencies partner with DataXu to better understand and engage their customers across all available media formats, devices, channels, and buying modes. Our11/20/2016 Boston, MA Save This Job
The Director, Program Management (level to be determined based on experience) is responsible to ensure adherence to the project scope, timeline and budget, and intervenes when necessary to identify and resolve issues in order to ensure timely completion of the drug development11/16/2016 San Francisco, CA Save This Job
Department: Sales Location: 710 North Drive - Melbourne, FL 32934 Avidyne Corporation is leading the general aviation (GA) industry in the design and manufacture of innovative and easy-to-use avionics systems. Avidyne is uniquely focused developing avionics systems that make11/16/2016 Melbourne, FL Save This Job
Department:420 - Analytics Location:Alpharetta, GA Click Here to Complete Your Application Seeking a Healthcare Business Intelligence Analyst Guru! Improving healthcare business performance, turning quality, risk and compliance efforts into opportunities, and creating, enhancing11/13/2016 Alpharetta, GA Save This Job
Sales Menlo Park, CA, United States As the Director of Sales you will be helping prospects/customers in the fundamentally change the way they analyze their complex data and build value for their companies. You are a seasoned software sales executive that has a successful track11/9/2016 Menlo Park, CA Save This Job
Type Full-time Company Anark Corporation provides powerful enterprise software and solutions to manufacturing organizations that need to cost-effectively utilize their 3D CAD data and manufacturing information for numerous down-stream applications, including: 3D Manufacturing11/9/2016 Boulder, CO Save This Job
at PatientsLikeMe (View all jobs) Cambridge As the Director of Scientific Operations you will work in partnership with the Head of Biology and Bioinformatics as well as with PatientsLikeMe senior management and working teams from Research and Policy, Project Management, User11/8/2016 Cambridge, MA Save This Job
Department: Regulatory Affairs Position Type / FLSA Status: Full Time / Exempt Location: Emeryville, CA Position Summary This position is primarily responsible for developing, coordinating and implementing regulatory strategies for new product development registrations,11/6/2016 Emeryville, CA Save This Job
Reports to: Vice President, Clinical Development Education: Board certification in Internal Medicine, and preferably additional Board Certification in Pulmonary Medicine or Oncology Job Description This role represents a unique opportunity for a physician experienced in11/6/2016 Boston, MA Save This Job
ABOUT ENANTA Enanta Pharmaceuticals, Inc. is a research and development-focused biotechnology company that uses its robust chemistry-driven approach and drug discovery capabilities to create small molecule drugs for viral infections and liver diseases. Enanta?s research and11/5/2016 Watertown, MA Save This Job
Product Pasadena, California Apply Opportunity The UX Team employs a highly collaborative style, helps establish a vision for the product and develops a consumer-grade UX for a complex business-to-business platform. The team uses a data-driven approach, employing user11/5/2016 Pasadena, CA Save This Job
Quality Assurance Fremont, California Apply Description Sr. Director, Quality Assurance Ardelyx is building an integrated biopharmaceutical company with a gastrointestinal and cardio-renal focus. Our mission is to serve patients through the discovery, development and11/1/2016 Fremont, CA Save This Job


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Birmingham Inverness Landing, with its lush landscaping and scenic lake views, offers the serenity and privacy of a home with the convenience of apartment living. Tucked away off Highway 280, you will find Birmingham's biggest and best secret. This premier apartment community boasts the largest on... To learn more please → Read More
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We've found more than 3 senior assisted living facilities in the zip code 21702. Assess your senior care needs with a caring advisor, we've helped more than 35 families in the 21702 area find senior care to match their unique needs and budget. Get pricing info and insider information on assisted living facilities in the 21702 zip code.
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Choose from over 3 Assisted Living communities in and read 39 reviews with an average rating of 4.3 stars out of 5.
We've helped 35 families in where Assisted Living will typically range from $2940.00 to $5940.00 per month.
Somerford Place - Frederick is our Alzheimer's Assisted Living community, and is on the same campus as Somerford House - Frederick, our Assisted Living community. Both properties are owned by Five Star Senior Living and located on the same campus. Somerford Place offers assisted living specifically...
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Provides: Assisted Living in Frederick, MD
Sunrise of Frederick is an assisted living community in Frederick, Maryland, located just blocks from The Golden Mile (Route 40 west). Sunrise of Frederick is nestled in a suburban, convenient setting. We pride ourselves in our experience in Frederick County with nearly 15 years serving seniors in...
5 miles from 21702
Odyssey Assisted Living at Montevue is an assisted living community located in a quiet, unique and upscale neighborhood in Frederick, MD. It is a world-class memory care community living designed to assist residents to remain social, while enjoying the things that they loved doing before their...
4.4 miles from 21702
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amymenges Review
Great retro look
These offer great style for the price. I tend to loose my sunglasses on a regular basis, so price is key for me. I like the retro cool look of these shades and hope they stay in my possession for a while!
- How did the color on site compare with the actual product? spot on
- Please tell us about the quality of the product. Quality is solid. The ear pieces are a little stiff to unfold, but that's better than too loose, in my opinion. Plastic is durable enough, given the price.
- How accurate was the sizing? Size isn't an issue.
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text: Book Reviews Events Surrounding EDSAC Science 01 Aug 1986:Vol. 233, Issue 4763, pp. 583DOI: 10.1126/science.233.4763.583 MICHAEL R. WILLIAMSFind this author on Google Scholar Find this author on PubMed Search for this author on this site Article Info & Metrics eLetters PDF This is a PDF-only article. The first page of the PDF of this article appears below.


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Guy Standeven has been supplying food processing
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A Good Deal: No Evil 022
Round up4.27 / 5.00 2,748 Views
Park Bench
A short film about a park bench4.16 / 5.00 2,196 Views
frog thing
frogggsgsgs3.79 / 5.00 2,540 Views
Log in to save your medals! Don't have an account? Create one for free!
really funny i completed it like this.
1.get all titans
2.let your heroes stay back until you have all monsters.
great game
It really was a great game, I played it for a couple days and finally got all the medals. My best combination consisted of Sky Dragon, Celestial Angel, Phantom Ghost, Were-Tiger and the other two didn't really matter what they were, but it usually was Orang Utan and Untamed beast. I didn't really use the Heros I kept them back the whole time to either defend the castle or just so they wouldn't die.
great game
for those who are wondering about the goblin level (13).
i found the way to defeat it on epic mode was to have 4 of the following.
1. sky dragon
2. meteor strike (to kill the black imps quickly)
3. invulnerability.
4. patience.
as far as the game itself, would of been nice to have included a turn off button for the music. an autosave feature would of been nice too... other than that, it's addicting.
great game
It is a good game. It seems a little long. It takes a while to grind and unlock everything. Really enjoyed the surpise during level 16 on epic mode. I did figure out how to kill the black goblins. I thought that was a good idea.
amazing game


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Product Manager, Desktop Apps
Slack is seeking a product manager to help make Slack great on macOS, Linux, and Windows. The ideal candidate has extensive experience as a product manager of desktop applications, particularly those relating to messaging, and has performed well in large and quickly expanding organizations.
- Develop product strategy and roadmaps for our desktop clients with a cross-functional team of engineers, designers, marketing, accounts teams, and customer support.
- Along with engineering leadership, develop appropriate planning, prioritization, and release management processes to enable us to launch new features across platforms at a fast clip, while ensuring the stability and overall quality of our native desktop experiences.
- Drive superb execution against plan, anticipating staffing needs, risks, and the need for frequent and clear communication internally and with customers.
- Prioritize and design features for the millions of customers who use Slack at work every day, all day.
- Product management experience building and maintaining desktop products used by millions of users
- Strong technical background to enable you to contribute meaningfully to projects intended to improve performance, stability, and maintainability; previous engineering experience is a plus
- Passion about Slack and the problem we are solving, and how people work with Slack on computers
- Voracious appetite for the latest news in desktop software to keep us apprised of new technologies and best practices
- Relentless desire to understand customers
- Deep experience building on Windows or macOS; ideally both
- Natural talent for mediating competing interests and finding creative solutions
- Great track record of working with engineering and design teams: people want to work with you again
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- on Education & Information
- Published in issue 5/2004 on page 0
Sensors for Humans
Sensor technology at MIT
Polymer electronics for chemical sensors: a new field is developing faster than expected. The first results include nanotechnology sensors that can detect chemical compounds such as TNT with an incredible level of sensitivity.'Polymer Electronics for Chemical Sensors' was the topic for the tenth research and development conference at the Massachusetts Institute of Technology (MIT), which gave an overview of current developments in the field of plastic electronics. The name of one speaker made us prick up our ears: Professor Timothy M. Swager is associate director of the 'Institute for Soldier Nanotechnologies' at MIT. What was he seeking to achieve?
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text: No recent wiki edits to this page. The host of heaven watch as their king draws his last breath unable to speak,unable to comprehend.As Jews cry aloud to Christ saying,"He raised others from the dead why cant he rais himself".The hosts cry aloud alongside but shortly thereafter they're attacked by forces of darkness which believe they've won.Skies On Fire picks up perfectly where the last issue left off. Issue three concludes the Fall trilogy and closes well.But many things were left off.


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Take your sex life to new heights with the Ramp and the Wedge from Liberator. This is from the Black Label line, which is Liberator's bondage line of sex positioning furniture. You will receive both furniture pieces with restraints, four cuffs and an eye mask, all of which may be used together and separately. The Ramp and the Wedge are covered in completely washable fabric. The fabric is a specially textured microfiber that is extremely soft against the skin and holds to itself, so that you can arrange the Ramp and Wedge exactly as you want them and they will stay put. The high density foam used is firm and comfortable - you and your partner won't sink into Liberator furniture! The Liberator Position Guide is included. You don't know how good sex can be until you've tried Liberator!
Please Note: The cuffs and eye mask included with the Ramp and Wedge are black, not cheetah print as shown in the images.
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From $2,700 / week
Description from the manager
Description from the manager
Bedrooms: 5/
Bathrooms: 4/
Sleeps: 10/
Type: House
Book this 5 bedroom, 4 bathroom house in Orleans today! A total of 10 people can sleep here comfortably.
Guests can enjoy a outdoor grill, air conditioning, and parking space among other amenities offered by this rental.
Travelers are sharing their opinions on this property. It has an overall rating of 5/5 thanks to 1 review.
Costs vary, with the average weekly rate as low as $2,700.00 to as high as $3,000.00, depending on travel dates.
The owner responds to 40% of inquiries, which is lower than average, and last updated the property's calendar today.
About the manager
About the manager
Beach Road Vacations
Beach Road Vacations
- Response rate: 40%
- Response time: A few hours
- Calendar updated: today
Overall rating:
4.4 / 5.0
Proximity to TripAdvisor's Top Orleans Attractions
Proximity to TripAdvisor's Top Orleans Attractions
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Pet Sitting & Drop In Visits in Arundel, DE
Book a pet sitter to stop by your home a few times a day to feed and play with your cat or dog.
To ensure accurate availability & pricing, please add your drop-off and pick-up dates.Dismiss
Pre-Vet Grad & Zookeeper in Newark!
Newark, DE, 19711
House Sitting, Drop-In Visits, Dog Walking
"Andrea spends quality time with Buster & sends cute photos! (more)"
Dog Mom living in a Human World
Wilmington, DE, 19808
Dog Boarding, Drop-In Visits
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Your Dog's Home Away From Home
Bear, DE, 19701
Dog Boarding, Drop-In Visits, Doggy Day Care, Dog Walking
"My wife and I were very happy with how Coleen did watching our dogs. Coleen did a total of 3 drop in visits to take our dogs outside, give them food and wa... (more)"
energetic, dedicated, kind hearted
Newark , DE, 19711
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Wilmington, DE, 19808
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Newark , DE, 19711
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About: Caring for animals has always been a passion of mine. I worked as a vet assistant for two years. I worked for a mobile vaccine clinic and for banfi... (more)
Energetic Registered Nurse
Newark, DE, 19702
Drop-In Visits, Dog Walking
About: I have two dogs of my own and I've had a couple dogs throughout my life. I understand them well, and I don't mind energetic hyper dogs who get over... (more)
animal lover of all kinds!
Newark, DE, 19711
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About: I started working with animals with I was 15. I had a Boston terrier named Oscar, but at 15, I started working at Windcrest Animal Hospital as a ke... (more)
Clean and Organize Home
Wilmington, DE, 19808
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"Amel was great with my lab. She played with him more than expected. when my lab came home he was worn out. She said she did 3 miles with him each day. I was ... (more)"
Always willing to lend a paw!
Wilmington, DE, 19808
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About: I'm 22 years old and in college now. I grew up with two dogs and two cats, volunteered to dog handle for the DE SPCA, very flexible on hours and di... (more)
Newark, DE, 19711
Drop-In Visits, Dog Walking
About: Happy Hound Cat and Dog Services provides loving care in your home for cats and dogs. I come to your home while you are away and visit, feed, give ... (more)
Experience exceptional service and a personalized match
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Rover also offers pet setting & drop ins in:
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|Brandywine Springs Manor, DE
|Duncan Woods, DE
|Faulkland Woods, DE
|Heritage, DE
|Marshallton, DE
|Pike Creek, DE
|Pike Creek Valley, DE
|Stanton, DE
|Wood Mill, DE
Rover.com is the simple, savvy way to find and book Arundel drop in pet sitting. It's easy to find the perfect pet sitter — many sitters have offered pet sitting on Rover for years, and 95% of reviewed stays have received a perfect five-star rating. You'll get daily photo updates, and every stay booked through Rover also includes premium pet insurance, 24/7 support, and a reservation guarantee. Pet sitters on Rover have the option to complete a free background check, which you can see from their background check badge. Pet sitters are booked on Rover every minute of every day, and 92% of the population lives within a short drive of one of the more 60,000 sitters who've listed their services on Rover, so you're sure to find the perfect pet sitter in Arundel. When you book with one of our trusted pet sitters on Rover you get peace of mind that your home and pets are in loving hands.


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Around the world there is an increase in surveillance of individuals by private and public organizations. Artist Adam Harvey has devised a way to help people get some privacy back from electronic surveillance through his fashion line Stealth Wear.
If you're in London you can see the artwork at Primitive Art Gallery.
In . . . → Read More: Things Are Good: Stealth Hoodie Protects Your Privacy


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The Coathangers Nosebleed Weekend on Limited Edition Colored LP + Download
First Pressing on Colored Vinyl
Colored Copies Are Limited / Call To Confirm Colored Copies Are Still Available
When The Coathangers started up in 2006, their aspirations were humble. "I think all bands in their early twenties start for fun," says guitarist/vocalist Julia Kugel when talking about their early years of cheeky no-wave and irreverent garage rock. But Julia and her bandmates Meredith Franco (bass/vocals) and Stephanie Luke (drums/vocals) were serious about their craft, and that combination of modest outside expectations and absolute dedication to their music made for exhilarating live shows and contagious records.
Ten years later, The Coathangers are still going strong, and while their palette has expanded over the years to touch upon hip-shakin' classic rock, soulful country ballads, and golden oldies pop, their primary attack strategy still relies heavily on the jagged hooks and boisterous choruses of their formative years. Their fifth album Nosebleed Weekend retains all the devil-may-care magnetism and serrated instrumentation of their debut, but it flourishes with a decade's worth of songwriting discipline and chemistry.
Nosebleed Weekend kicks off with "Perfume", a song that marries sultry pop vocals with toothy guitar riffs in a manner that would make Ann and Nancy Wilson proud. It's hard to imagine The Coathangers writing a song this accessible in their early years, but in 2016 it fits perfectly into their canon. From there the band launches into "Dumb Baby," which harkens back to the gritty neo-garage rock of Murder City Devils. Longtime fans who still clamor for their brash post-punk angle will be immediately satiated by "Squeeki Tiki." And after hearing the noisy loud-quiet-loud bombast of "Excuse Me?" it's no wonder that Kim Gordon has become an outspoken fan of the band.
It's an eclectic album inspired by life on the road, lost loved ones, and Kugel's recent move to Southern California. "We always say that each record is a snapshot of our life at the time," Kugel says. "As far as style...it's just what came out of us at that point." So whether it's the foreboding garage rock of the title track, the post-punk groove of "Burn Me," the stripped-down pop of "I Don't Think So," or the dynamic grunge of "Down Down," The Coathangers command their songs with passion and authority.
1. Perfume
2. Dumb Baby
3. Squeeki Tiki
4. Excuse Me?
5. Make It Right
6. Nosebleed Weekend
7. Watch Your Back
8. Burn Me
9. I Don't Think So
10. Down Down
11. Hiya
12. Had Enough
13. Copycat
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text:
Artlyst Podcast: Justin Mortimer On Skidding Paint And New Directions
Parafin Gallery, London is currently displaying the latest works by British painter Justin Mortimer. The artist's painting reflects upon a figurative world in a state of 21st century 'Baconian' disorder, often pushing the boundaries of figuration and landscape with a slight fetishistic overtone. But with this latest series of works the artist's usual necrotic hues give way to the artificial colours of medical garments and smoke bombs found in images from the ongoing Ebola crisis in Africa, and recent political disturbances.
Mortimer creates a voyeuristic tableaux from a collage of internet-sourced images, often returning to motifs and re-working them as he strips back the images to reveal a disturbing narrative of suggested violence and physical oppression - but also one of beauty. The artist's usual focus on the 'victim' in the obfuscated narrative of his work is no longer the central leitmotif of the Mortimer's painting. The artist's broken and distrubing nudes of Mortimer's amoral Goya-esque performances are reduced, as is the artist's fetishistic tone
The viewer is still met with a shifted focus and a subversion of intent, there is still the nature of unease, as if the viewer is being unwittingly drawn into some sort of sordid event, the centre of which is blocked or even in the case redacted via the intentional removal of a key to the narrative.
In the second part of his conversation with Artlyst Justin Mortimer discusses the ongoing narrative of his painting, and the direction the artist may take his work in the future.
Justin Mortimer: Kult - Parafin Gallery - until 27 June 2015
Words: Justin Mortimer with Paul Black. Photos: courtesy of Parafin Gallery © and P A Black, 2015 Artlyst all rights reserved
Read part one here


text:
The quest for medical treatments for patients with advanced stage hepatocellular carcinoma (HCC) has met repeated road blocks with failed therapies. These failures have been well documented in a number of reviews and in the American Association for the Study of Liver Diseases HCC practice guidelines. A major breakthrough in systemic treatment occurred with the advent of targeted therapies that block specific cancer-promoting signaling pathways. For HCC, the era of molecular targeted therapy began with the SHARP trial.[1] In this phase III trial, sorafenib, an inhibitor of RAF serine-threonine kinases and the receptor tyrosine kinase activity of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor beta (PDGF-B), or placebo was administered to patients with Child-Pugh class A cirrhosis and mainly advanced HCC, compatible with stage C disease according to the Barcelona Clinic Liver Cancer (BCLC) staging system. Sorafenib-treated subjects experienced an extension in median survival compared with placebo-treated subjects of about 3 months, accompanied by tumor stabilization due to delayed tumor progression. These results suggest that sorafenib acts mainly as a cytostatic agent. This pivotal study led to approval of sorafenib by regulatory agencies in the United States and the European Union in 2007 and cemented sorafenib as the standard first-line treatment for advanced stage HCC. The clinical success of sorafenib provided the first proof of concept that targeting up-regulated molecular signaling pathways and angiogenesis in HCC can be efficacious. This achievement spawned the clinical development of already approved targeted agents in other malignancies and new molecular targeted therapies for advanced HCC.
Systemic targeted therapy beyond sorafenib
Potential conflict of interest: Roniel Cabrera is a consultant and has received research grants from Bayer/Onyx and Bristol-Myers Squibb.
Watch a video presentation of this article
Watch the interview with the author
hepatocellular carcinoma
platelet-derived growth factor receptor
Response Evaluation Criteria in Solid Tumors
vascular endothelial growth factor receptor
Development and Progression of Cancer
The development and progression of cancer is a multistep, complex process that involves acquiring hallmark features to sustain tumor growth. Conceptually, this framework was revisited as our understanding of the mechanistic underpinnings of cancer has improved over the last decade (Fig. 1).[2] The prior hallmarks included sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. The updated framework now includes genome instability, inflammation, reprogramming of energy metabolism, and evading immune destruction. Although our knowledge of the molecular pathways necessary for tumor growth and progression continues to evolve, new targets continue to be identified for drug development. A number of drugs targeting specific signal transduction pathways showed promising results in early phase clinical studies that led to phase II and III clinical trials in advanced HCC. The current treatment strategies of these trials include: (1) single agents that inhibit novel targets; (2) multiple targeted agents combined to inhibit the same or different molecular pathways; (3) combining targeted agents with conventional chemotherapy; and (4) combining molecular targeted agents with liver-directed therapies (treatment stage migration). Table 1 summarizes the planned, ongoing, and completed clinical trials for advanced HCC. A brief overview of recent failures and ongoing clinical studies with emerging molecular targeted agents along with future perspectives is discussed below.
|Sorafenib versus placebo
|Phase III: approved (2007)
|Sorafenib versus sunitinib
|Phase III: halted (2010)
|Sorafenin versus brivanib
|Phase III: failed
|Sorafenib versus linifanib
|Phase III: halted (2011)
|Sorafenib ± erlotinib
|Phase III: failed
|Sorafenib versus bevacizumab ± erlotinib
|Phase II: ongoing
|Sorafenib ± doxorubicin
|Phase III: ongoing
|Brivanib versus placebo
|Phase III: failed
|Ramucirumab versus placebo
|Phase III: ongoing
|Bevacizumab ± erlotinib versus placebo
|Phase II: ongoing
|Everolimus versus placebo
|Phase III: ongoing
Current Treatment for Advanced HCC: Sorafenib and Lessons Learned
Sorafenib targets both the tumor compartment by inhibiting Raf kinase proliferative signaling and tumor angiogenesis by blocking the VEGF and PDGF receptor tyrosine kinases.[3] Preclinical studies have shown that Raf kinase signaling and tumor angiogenesis together play an important role in the evolution of HCC, lending a molecular rationale for the use of sorafenib in this malignancy.[4] This knowledge along with the early signal of efficacy in a phase II study (median overall survival of 9.2 months) led to the phase III SHARP registration trial.[1, 5] The SHARP trial compared single-agent sorafenib with placebo in patients with advanced HCC and Child-Pugh class A cirrhosis, the majority of whom had either only chronic HCV (approximately 30%) or alcoholic liver disease (26%) as the cause of their cirrhosis. Treatment with sorafenib significantly improved overall survival (10.7 months) compared with placebo (7.9 months), with a hazard ratio of 0.69 (P < 0.001) that was both statistically and clinically significant. Further, the time to radiological progression was significantly longer in those patients treated with sorafenib (5.5 months) compared with patients receiving placebo (2.8 months). In terms of tumor responses, only seven patients in the sorafenib group (2%) and two patients in the placebo group (1%) had a partial response according to Response Evaluation Criteria in Solid Tumors (RECIST), while no patients had a complete response. Single-agent sorafenib versus placebo was also evaluated in a second phase III trial (the Asia-Pacific trial) for patients with advanced HCC.[6] The Asia-Pacific trial largely confirmed the survival benefit of sorafenib (6.5 months) over placebo (4.2 months) with a hazard ratio of 0.68 (P = 0.014), but not to the same degree as seen in the SHARP trial (Table 2). Both of these phase III trials demonstrate a modest improvement in median overall survival for sorafenib compared with placebo in patients with advanced HCC.
|SHARP Trial
|Asia-Pacific Trial
|OS, months
|0.69 (0.55-0.87)
|0.68 (0.50-0.93)
|TTP, months
|0.58 (0.45-0.74)
|0.57 (0.42-0.79)
|Response rate, %
Anti-angiogenic Agents
Sunitinib is an oral tyrosine kinase inhibitor that targets receptor kinases that include vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, platelet-derived growth factor receptor (PDGFR)-a/b, c-KIT, FLT3, and RET kinases.[7] In contrast to sorafenib, sunitinib has more potent activity against VEGFR-1 and VEGFR-2. Initial single-arm phase II trials with sunitinib in advanced HCC showed modest antitumor activity.[8, 9] A randomized phase III study comparing sunitinib (37.5 mg daily) with sorafenib (400 mg twice daily) in patients with advanced HCC found a higher incidence of serious adverse events in the sunitinib arm before its early termination by an independent data monitoring committee.[10] In addition to higher toxicity, the sunitinib arm was also inferior to sorafenib, with a significantly shorter median overall survival (7.9 months) versus sorafenib (10.2 months) with a hazard ratio of 1.30 (P = 0.001). Based on these findings, sunitinib does not have clinical activity in HCC.
Brivanib is a dual inhibitor of VEGFR and fibroblast growth factor receptor signaling pathways. In a single-arm phase II trial studying the safety and efficacy of brivanib in patients with advanced HCC (n = 55), brivanib demonstrated a median overall survival of 10 months as a first-line treatment with tolerable adverse effects.[11] Brivanib also demonstrated activity as a second-line agent in sorafenib-refractory patients with advanced HCC with a median overall survival of 9.8 months (n = 46).[12] These promising phase II studies led to the phase III clinical development of brivanib. Unfortunately, in the phase III study in patients with advanced HCC as a second-line agent, brivanib failed to improve overall survival compared with best supportive care.[13] A recent press release by Bristol-Meyers Squibb also reported that the phase III study comparing brivanib to sorafenib in advanced HCC also failed to meet its primary survival objective.[14] As such, brivanib does not have clinical activity in HCC.
Additional Anti-angiogenic Agents
Linifanib (ABT-869) is another VEGF and PDGF inhibitor that was studied in a phase II study with advanced HCC (n = 44).[15] The study reported an objective response rate of 6.8% that was only noted in patients with Child-Pugh class A cirrhosis. Patients with Child-Pugh class A cirrhosis received linifanib at 0.25 mg/kg daily and achieved a median overall survival of 10.4 months. The favorable survival led to a phase III trial comparing linifanib with sorafenib, which was terminated recently based on the recommendation of an independent data monitoring committee.[16] Ramucirumab (IMC-1121B) is a human monoclonal antibody that binds to VEGFR-2 and was evaluated in a phase II study in patients (n = 43) with advanced HCC. As a single agent in sorafenib-naïve patients with HCC, it demonstrated a tumor response rate of 10% and was associated with gastrointestinal bleeding (9%; grade 3/4), hypertension (14%; grade 3/4), infusion-related reactions (5%; grade 3), and a median overall survival of 12.0 months.[17] Ramucirumab is under evaluation in a phase III study as a second-line treatment in patients with advanced HCC who fail first-line treatment with sorafenib (the REACH study). Several other VEGF inhibitors are in the early stages of clinical development and have not entered phase III trials, including bevacizumab, cediranib, and axitinib. In general, the recent failures with inhibitors of the VEGF pathway such as sunitinib and brivanib raise concern about continuing to target this pathway. Going forward, a key to the ongoing clinical development of anti-VEGF therapies will be identifying markers that predict patients most likely to benefit from treatment and ensuring that anti-RAF activity is present with agents.
Epidermal Growth Factor Receptor Inhibitors
Although a number of epidermal growth factor receptor inhibitors have been evaluated in single-arm phase II studies, only erlotinib has shown modest antitumor activity. In a single-arm phase II trial monotherapy in patients with advanced HCC (n = 38), erlotinib demonstrated a median overall survival of 13 months.[18] A phase III study (the SEARCH trial) evaluating the combination of erlotinib with sorafenib versus single-agent sorafenib failed to meet primary end-point of overall survival.[19] Results demonstrated that the addition of erlotinib to sorafenib did not improve overall survival, compared with sorafenib alone. Another compelling combination occurs when using erlotinib and bevacizumab together. This combination when tested in a single-arm phase II trial in patients with advanced HCC (n = 40) demonstrated an impressive median survival of 15.6 months.[20] This clinically meaningful result has led to a phase II randomized study of bevacizumab and erlotinib compared to sorafenib monotherapy as a first-line treatment[21] and as a second-line treatment for advanced HCC.[22]
Mammalian Target of Rapamycin Inhibitors
Mammalian target of rapamycin is a key protein kinase that regulates cell growth, proliferation, metabolism and angiogenesis in many cancers including HCC.[23] Everolimus has shown good tolerability with promising efficacy in early phase I-II studies in heavily pretreated HCC cohort with an overall survival of 8.4 months.[24] These results have led to the phase III (EVLOLVE-1 trial) comparing the efficacy and safety of everolimus 7.5 mg daily with that of placebo in patients with advanced HCC that have progressed after sorafenib or who are sorafenib intolerant. However, the potential role of everolimus combination therapy in HCC will be a challenge. The incidence of adverse events with single-agent everolimus appears to be higher in HCC cohorts versus other solid malignancies likely due to the presence of cirrhosis. Future clinical studies looking to combine everolimus with other agents for advanced HCC should carefully select the combination to maximize antitumor synergism and minimize the overlap of safety profiles.
Hepatocyte Growth Factor/c-Met Inhibitors
Hepatocyte growth factor and its high-affinity receptor c-Met are involved in tumor cell migration, invasion, proliferation, and angiogenesis. Tivantinib (ARQ 197) is an oral inhibitor of the tyrosine kinase receptor c-Met and has shown promise in phase 1 HCC studies as monotherapy and in combination with sorafenib. The recent results observed with the randomized phase II trial comparing tivantinib (n = 71) with placebo (n = 36) in patients with advanced HCC who failed one prior systemic therapy met its primary endpoint of improving TTP.[25] Tivantinib treatment has a manageable safety profile and significantly benefited second-line HCC patients. A randomized phase III study with tivantinib as a second-line treatment is planned. Cabozantinib (XL 184) is a dual inhibitor of c-Met, and VEGFR-2 was also evaluated in a randomized dose discontinuation trial that showed antitumor activity and a safety profile similar to other VEGFR inhibitors.[26]
Sorafenib and Conventional Chemotherapy
Prior to the benefits of sorafenib demonstrated by the phase III SHARP trial, a randomized phase II trial of patients with advanced HCC to treatment with sorafenib plus doxorubicin versus doxorubicin alone was performed.[27] This study was halted once the survival benefit of sorafenib was established, making sorafenib the standard of care for advanced HCC. In this study, sorafenib plus doxorubicin, when compared with doxorubicin monotherapy, improved median time to progression (6.4 months versus 2.8 months; P = 0.02) and overall survival (13.7 months versus 6.5 months; hazard ratio, 0.49; P = 0.006). Presently, a large phase III trial (CALGB 80802) comparing single-agent sorafenib versus sorafenib plus doxorubicin to further explore the synergy of this combination is ongoing.
While a major advancement in the management of advanced HCC has been the clinical success of the oral multikinase inhibitor sorafenib, nearly 5 years after this major milestone sorafenib remains the standard of care for advanced HCC. The wave of molecular-targeted agents will certainly change the current landscape of treatment to one where targeted therapies will be used in the adjuvant setting and combined with locoregional treatments. However, a key focus during these trials needs to be advances in genomic and molecular profiling to identify subset of patients most likely to benefit and biomarkers predictive of response and that anticipate resistance. Critical to the success of future treatments will be our ability to incorporate the individual's genetic/epigenetic background, molecular profile of tumors, and predictive biomarkers in the design of clinical trials. Designing trials where treatment is tailored to clearly defined patients will expedite discovery and clinical development of new treatment approaches in a cost-effective manner.


text:
The average cost for a Oil Pan Reseal - Engine is between $358 and $493. Labor costs are estimated between $281 and $356 while parts are priced between $77 and $137. Get a personalized estimate based on your location and specific car. Estimate does not include taxes and fees.
Oil Pan Reseal Cost for Jeep Liberty
Oil Pan Reseal - Engine Estimate (National Average)
Validated estimate range for national average.
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Parts & Labor Breakdown
Labor: $281 - $356
Parts: $77 - $137
Estimate does not include taxes and fees.
Common Symptoms
Some engines have an upper and lower oil pan gasket; in these cases, we quote for the lower pan gasket only.
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The oil pan is on the bottom of the engine, so any oil leaks from the top or front of the engine could drain down and look like an oil pan leak. It's important to verify that there are no other leaks before having the oil pan resealed.
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Today, when I was ordering pizza, I got a text from my mom saying "I love you". When the man thanked me I accidentally said, "I love you too." FML
by lol112 / 06/02/2012 at 8:47am / United States (New Jersey) / Miscellaneous
Today, my parents grounded me for finding their stash of weed. The irony is killing me right now. FML
by ironyisabitch / 06/02/2012 at 1:43am / United States (California) / Miscellaneous
Today, I almost got kidnapped. Again. FML
by gonavybeatarmy / 05/31/2012 at 1:28am / United States (California) / Miscellaneous
Today, I walked in on my dad introducing his stuffed gorilla to his cat. FML
by Anonymous / 05/14/2012 at 11:52pm / United States / Miscellaneous
Today, a pigeon got into my apartment. After knocking over a very expensive vase, it panicked, rammed itself against a window, and shat all over the floor as it tried to get out. FML
by Eric Ngan / 05/12/2012 at 12:01pm / Singapore / Animals
Today, I brought my 90-year-old grandfather into school for a project that required to bring in "a first-hand account" of the Great Depression. He started off by telling the class how in his day, they "threw rocks at black people." FML
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Today, I went to a party dressed as a zombie. Everyone admired my hilarious "zombie dancing". Those were my regular dance moves. FML
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Today, I was shopping at Walmart, when I saw a really good deal on some bacon. Before I could take any, a huge-ass woman stormed over, kicked my cart down the aisle, and snatched every single packet for herself. And I actually got upset over this. FML
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Today, I asked my boyfriend if he would still love me if I became a vegetable. His response: "Well, the sex wouldn't be any different." FML
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Today, I walked in on my new puppy peeing on the carpet. The trainer had told me to punish her when she's bad by shaking a metal can of pennies at her, since the noise scares dogs. I shook it at her, and she responded by having explosive diarrhea all over the carpet in fright. FML
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text:
A middle-school teacher in California suggests engaging students in math lessons by creating activities that relate to the real world. Robert MacCarthy's students have created math music videos to songs and designed shirts with math problems on them. MacCarthy said he has added visual instruction to his math lessons to help students who are learning English.
Full Story:The Oakland Tribune (Calif.)


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Pros: Well made, usually available for quick shipment.
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James is a general reporter at Media Wales
There is now a campaign to find the man and thank him for what he did
The imam told followers that posting photographs on Facebook in makeup was a grave sin
They're living life to the full to make 'good' memories that they can share
His ultimate goal is to ask Ken Skates
There is concern for her life is at risk in Saudi Arabia
Donald Davies came up with an important idea which formed part of the world wide web
The complex science makes her 'whoop'
'It is not fair. He is a dead man and he cannot answer back'
It's been invented by a Welsh chef and costs £15 a throw
Experts say the likes of Twitter and Facebook could be to blame
Amina Al-Jeffery, who grew up in Swansea, wants the high court to order her dad to return her to Wales
Wales Online
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To book an advert with WalesOnline call 029 2024 4002, or email firstname.lastname@example.com.
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Event: Bollywood actors Ranbir Kapoor, Deepika Padukone, producer Karan Johar, and director Ayan Mukerji were snapped at the first look and trailer launch of their upcoming film YEH JAWAANI HAI DEEWANI. Aditya Roy Kapur was also present. While Deepika flashed her famous dimples and giggled throughout the event, Ranbir was at his wittiest best. Ranbir impressed with his antics.
Guest List: Ranbir Kapoor, Deepika Padukone, Karan Johar, Ayan Mukerji, Aditya Roy Kapur
Venue: PVR Juhu
Date: 19-Mar-2013
Sizzling HOT Bollywood actress Sonam Kapoor was snapped at the airport.
Cricketer Virat Kohli and Bollywood actress Anushka Sharma were snapped at the airport. Also spotted was legendry lyrist Javed Akhtar.
Bollywood celebs Amitabh Bachchan, Sushant Singh Rajput, Karan Johar, Rajkummar Rao, Aditya Roy Kapur, Saif Ali Khan among others were snapped at the airport.
Bollywood actor John Abraham was snapped at the unveiling of 2017 Nissan GT-R.
Bollywood celebs Abhishek Bachchan, Farah Khan, Sajid Khan, Kayoze Irani, Rajkumar Hirani among others were seen at Boman Irani's birthday bash.


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Check in from 8h / Check out prior to 11h
Quality Hotel Michelino Bologna Fiera: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Bologna, Italy.
Quality Hotel Michelino Bologna Fiera offers 3-star accommodation in Bologna. The multiple amenities this relaxed hotel features include massage services, meeting rooms and an express check-in and check-out feature.
Hotel description
This modern hotel offers luggage storage, room service and a 24-hour reception. Corporate amenities include a business centre.
There are 66 relaxed rooms at Michelino, each offering all the necessities to ensure a comfortable stay. Each provides its very own bathroom with a shower.
Michelino is close to Bologna Fiere Train Station, making it easy for guests to explore Bologna and its surrounding areas. University of Bologna and the International Museum and Library of Music are just an easy car ride from the hotel.
Hotel features
Room Service, Air Conditioned, Cable / Satellite TV, TV, Shower, En suite, Private Bathroom
Business Center, Elevator / Lift, 24 Hour Reception, Dry Cleaning, Safe-Deposit Box, Meeting Rooms, Laundry service, Photocopier, Luggage Storage, Express Check-In/Check-Out, Self Laundry
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This Get Well Soon Smiling Sun Balloon is sure to lift the mood of your poorly loved one. With a jolly, smiley face sun, this fun balloon design is perfect for brightening up hospital rooms or homes. Foil balloons enhance the décor for your most special celebrations, and at 45 cm, will create a striking visual. To add an even bigger splash of colour for your friends or family, mix these eye-catching foil balloons in with a selection of latex balloons of coordinating colours for maximum impact.
These balloons are designed to be long lasting and will float for up to a week when inflated with helium. Make sure to tether them to walls or balloon weights so that they don't float away!
Take your balloon into store with your order receipt and, for 75p, we can fill it up with helium!
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Torquay, Victoria, Australie
Our beach home was completely renovated just before we bought it in 2012. Because this isn't the house we live in year round, it is open to non-simultaneous...
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Our modern 4 bedroom home was built in 2009 and has many up to date features including a cinema room, an al fresco/BBQ area, formal lounge and large family area. Five minutes walk from the beach and located at the start of the world renowned Great Ocean Road, Torquay is part of the international surfing circuit where the famous Bell's Beach is located. Many restaurants and coffee shops are located within walking distance of our home.There are also many wineries and farm restaurants nearby.Each Saturday there is a farmers' market and monthly, a wider market offering clothing, books, food and music. Our house is centrally heated and air-conditioned and very comfortable. We know you will be very comfortable here.
Our beach home was completely renovated just before we bought it in 2012. Because this isn't the house we live in year round, it is open to non-simultaneous...
Stunning contempory residence in The Sands golf resort on Victoria's world famous surf coast. Downstairs: 2 bedrooms, bathroom and large living area opening...
Just over an hour from Melbourne, recently renovated beach house is walking distance to stunning surf beach, and national park. 3 comfortable bedrooms, ...


text:
Regina King, who plays Douglas' mom, dazzled the athlete with how well she captured her mother's essence.
"She is amazing. She's such a doll, and she played my mom so well. Me and my sister were joking around: 'Mom, she even played a better you,' " Douglas said. "She did a fantastic job portraying my mom, and she was definitely on point."
Although she has accomplished more in her 18 years than most people will in their entire life span, Douglas remains humble, grounded and focused. She encourages her fans and anyone who might see the movie to take heart and continue believing in themselves.
"I just want them to see—of course, yes, my life story—but I want them to see that things are possible. And I went through some things in my life that were very difficult, and I went through struggles, and I want them to see that it is possible. And if they're going through something in their life, I want them to know that they can overcome it," she added.
Where Douglas' journey will eventually lead is anyone's guess. She fiddles with the idea of acting, launching her own fashion line, performing on Dancing With the Stars and other big dreams—all of which are more than possible through the opportunities won by her hard work.
She'll even dabble in sportscasting at this year's Super Bowl.
"I'm a correspondent for Inside Edition for the Super Bowl, and I'm really excited because I'm a really big fan of football," the Patriots fan said. "I'm just a little sad that my team didn't make it, but it's all good; maybe next year.
"But I'm going to be … on the field, and I'm going to have such a fun time," she added. "This is going to be my first time at the Super Bowl. It's going to be so different because I've always been sitting at home watching it, so it's going to be just different, but I'm really excited about it."
But her short-term goal is much more focused. She has her eyes set once more on one of the world's greatest athletic competitions.
"I'm training right now, and everything's going smoothly, and hopefully I'll be competing by this year, and yes, the main goal is 2016," she said, referring to the Summer Olympics in Rio de Janeiro.


text:
Where can I find Smoky Mountain Mineral Makeup other than ebay? I don't really like using ebay to purchase things.
PeggyGV from San Antonio, TX
HI, YOU CAN GET IT AT smokeymountainminerals.com. IT IS THEIR ON-LINE STORE. GOOD LUCK
Add your voice! Click below to comment. ThriftyFun is powered by your wisdom!


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03-10-2004, 02:17 PM #1Newbie
- Join Date
- May 2003
- Posts
- 15
Setting up an internet radio broadcast on a webserver...
Does anyone know how to set up a radio broadcast thing (I assume it would be through Winamp) on a webserver so that visitors can tune in to it?
PLEASE e-mail me ([email protected]) or IM me: Umpakati if you know how and what you'd like in return.
03-10-2004, 10:40 PM #2Web Hosting Master
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- Dec 2002
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google is your friend:
look at this pic lol: http://www.420th.com/temp/google.jpg
lolwebmaster A T 420th.com
What is my Itunes playing? Visit 420th.com/nowplaying.jsp to find out.
Ask the monkey: http://www.monkeyfaq.com
03-11-2004, 01:24 AM #3Web Hosting Guru
- Join Date
- Nov 2003
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- Earth
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http://www.shoutcast.com/ is the best audio streaming server with Winamp and very user-friendly. give it a try.
03-11-2004, 11:12 AM #4Newbie
- Join Date
- May 2003
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- 15
I have seen those two links before, but I have my own host and those don't really explain to me what I need to do.
So, ilyash, it really wasn't a "dumb" question and I DID try Google.
03-11-2004, 02:53 PM #5Web Hosting Master
- Join Date
- Jun 2002
- Location
- United Kingdom
- Posts
- 1,236
What Operating System is this for?
Either way, download the shoutcast server, and edit the config file. www.shoutcast.com
if you host is linux then download sc_trans, this is used to source the shoutcast server.
also edit the config files for sc_trans
once u have done that, its all complete
if u need help let me know
03-30-2004, 09:49 PM #6Newbie
- Join Date
- Apr 2002
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- Posts
- 10
icecast for streaming
I've been looking for something to setup an online radio and was offered the icecast.
is anyone familiar with this server?
would appreciate all feedback