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Prices, promotions, styles and availability may vary by store and online.
Action - Bolt Action
Caliber - .204 Ruger
Barrel Length - 24"
Weight - 10.0 Lbs.
Sights - Drilled & Tapped
The Howa M-1500 is one of the best known barreled-action rifles on the market and is the most popular of all of Howa's rifles. The M-1500, while being comparatively low priced next to other overseas models, has been judged to have all the delicacy and robustness one would expect from Japanese engineering. The 1500 is set apart by a unique floor magazine and a free-floating barrel for optimal accuracy. This rifle features a grey laminate rollover Monte Carlo stock with a righthand palm swell, a stainless steel barrel and receiver, and a standard safety and has been drilled and tapped for scope mounts. Its stock, metal, and bore are all in excellent condition.


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THIS IS A DIRECTORY PAGE. Britannica does not currently have an article on this topic.
Learn about this topic in these articles:
development by Soviets
...submarines for export. Although the Soviets continued to build diesel submarines, the bulk of their new construction shifted to nuclear power after their first nuclear submarines, of the November class, entered service in 1958. Since the dissolution of the Soviet Union in 1991, Russia has continued the policy of maintaining a mixed nuclear-conventional submarine force. In 1968 the...

subset: commoncrawl


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"Strada" – by Tabarka Studios
Inspired by the beautiful building entrances and residential floors in Paris, the modernist Barcelona of Gaudi and the spectacular villas in Spain and Italy. The Strada collection of cement encaustic tile is the latest collection from Tabarka Studios.
STRADA 12 – 8″ hexagon
Lots of new items coming in this fall!
Walter Zanger, Kaza (concrete) winner of Best KBIS 2016 Kitchen Produced.
Kaza Concrete designs are available in angular geometric or soft curve patterns.
Produced with state of the art technology, appropriate for interior, exterior applications.
Contact us for more details:
World Mosaic (BC) Ltd
Vancouver, BC
Fax: (1) 604-736-9908
Email: email@example.com
Hope everyone had time to enjoy the gorgeous weather of the holiday.
We are open with regular hours:
Tuesday – Friday: 8,00 – 4,00
Saturday: 10,00 – 4,00
Tuesday – Friday: 9,00 – 5,00
Saturday: 10,00 – 4,00
Hope to see you soon!
Love It or List It Vancouver Sneak Peek
A sneak peek of tonight's all new episode of Love It or List It Vancouver featuring the beautiful Jillian Harris and our hand-crafted terracotta hexagons.
Good luck Todd, you're gonna need it!
World Mosaic's tile on all new Love It or List It Vancouver episodes
You will love what Jillian Harris has done with our tile on all new episodes of Love It or List It Vancouver, now airing on the W-Network on Monday nights!
From bathrooms, to feature walls, to kitchen backsplashes, celebrity host Jillian Harris has hand picked some of her favorite World Mosaic tile to feature on the hit show Love It or List It Vancouver. We love how Jillian has used glass tile, porcelain tile as well as natural stone in order to make every space truly unique.
Shown in this sneak peek photo is Spring Fling, a hand-crafted, recycled glass tile by Oceanside. This is a lovely blend of colours that will bring a clean pop of colour to any space. Not a fan of yellow? No problem. All Oceanside glass tile is completely customizeable so you can make your own colour blend in order to match your own tastes and personality.
New Collection- Hand Painted Terracotta
Introducing the new Walker Zanger, Duquesa collection now available at World Mosaic Tile!
Duquesa is an assortment of hand painted terracotta inspired by Persian textiles, Portugese tiles and Moroccan mosaics. This collection will bring elegance and interest to your kitchen backsplash, make a statement as a feature wall or provide dimension to your fireplace. Come into World Mosaic to see the many more patterns and colours available in this fabulous new collection!
Check out this collection on Walker Zanger's website for additional photos and installation ideas.
5 Backsplash Trends for 2015
As 2014 comes to an end World Mosaic Tile looks into the New Year for the top trends in backsplash tile. Here are 5 backsplash tiles that will make waves in 2015!
1. Sophisticated Geometric
Use Tagina's Etoile pattern for a unique backsplash feature in your kitchen. Available in an 8×8 or 24×24 these porcelain tiles can be installed tight together for minimal grout joints. Did we mention these tiles are in stock?
2. Penny Rounds & Hexagons
Hexagons and penny rounds are no longer restricted to the floor, they now beg to be used as a backsplash tile. From a bright blue to a classic white, the colour choices are endless. These tiles will create a fresh and inviting look for your kitchen.
For colours available at World Mosaic check out our Gallery
3. Bright Glass Tile
Make a statement in your kitchen with a vibrant glass tile. Choose an Oceanside Glasstile in your favorite colour and mix up the various sizes or pick a colourful geometric pattern to really make your backsplash pop. For more glass backsplash ideas check our Oceanside GlassTile Collection.
4. Decorative Stone
For a backsplash that calls for elegance with a twist try Walker Zanger's Jet Set collection or their brand new Tangent collection. From Calacatta in a chevron pattern to a Carrara cut into a woven arabesque shape, these unique laser cut patterns bring decorative stone to the next level.
5. Hand painted Terracotta
Having the ability to choose the size, shape and colour of your backsplash tile makes your kitchen truly unique. Choose from patterns inspired by tribal motifs of the Touareg tribe in North Africa, the timeless elegance of the Metro Stations of Paris, or the medieval Palio Festival of Italy. These are just a taste of the many patterns available for this hand-crafted terracotta. Where will your Tabarka backsplash take you? For more ideas check out our Tabarka Collection.
Shower in Freedom Smart Porcelain
Peach Interior Design chose our Freedom Smart porcelain for the shower walls in this cheerful bathroom. For additional project photos check out Peach Interior Design's website www.peach.ca
*New* Stonewave – a porcelain that looks like a limestone
Introducing Stonewave, our newest in-stock, Italian porcelain! This textured porcelain is available in both warm and pure, and looks exactly like a limestone. Unlike a real limestone there is absolutely no maintenance required! Come into World Mosaic for a sample of Stonewave for your next project!
New Customer Photos!
Pacific Dental Centre created an inviting and stylish office area using World Mosaic tile. Here is a lovely installation photo of our Dordogne porcelain in a subway and 16×24. Oceanside Glasstile in Midnight Express was installed for a unique accent around the desk. The glass looks fabulous doesn't it?!


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James HawkinsEducator the Year
By Ashlee Green, NABJ Program Assistant
Remember Me
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11/17/2016NABJ and Morgan State SGJC Offer Trip to Cuba
11/16/2016Journalism Organizations Send Joint Letter To President-Elect Trump
11/16/2016Memorial Service Details Released for Gwen Ifill
1/21/20172017 NABJ Board of Directors Winter Meeting
3/15/2017 » 3/18/201725th Annual NC A&T University Multimedia Short Course
3/16/2017 » 3/19/2017Florida A&M University Multimedia Short Course


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Videos tagged "E-kartingnews"
First trailer for the 2013 Film "Become One". A quick look at what is going to be an in depth karting documentary that will feature drivers from all over the world racing Stock Moto, Rotax,…+ More details
What are Tags?
Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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FREE SHIPPING on orders over $50.
Quantity Available:
Cleveland-based Hinkley Lighting is driven by a passion to combine design and function to create exceptional lighting solutions. Family-owned Hinkley began as a traditional lantern company in 1922, and, still today, they produce top quality outdoor lighting. Hinkley Lighting has also expanded to include a full range of interior lighting solutions, including chandeliers, sconces, pendants and vanity lights.
The Saturn Post Mount is available with the following:
- Cylindrical Opal shade
- Fluorescent option is Title 24 compliant
- Post not included
- UL Listed Wet
- Made In China
Finish: Metro Bronze, Stainless Steel
Light Option: Incandescent, Fluorescent, LED
- Halogen Option: One 72 Watt (1490 Lumens) 120 Volt E26 Medium Base Halogen Lamp(s) (Not Included)
- Fluorescent Option: One 26 Watt (1750 Lumens) 120 Volt GU24 Base Fluorescent Lamp(s) (Not Included)
- LED Option: 15 Watt (1100 Lumens) 120 Volt Integrated LED: CRI: 90 Color Temp: 2700K
Compare Brightness:
LumensThe amount of light that comes from a bulb, which has commonly been measured in watts. The more lumens, the brighter the bulb.
WattageA measurement of the power delivered to a component of an electric circuit (allowing a one-ampere current to flow through the component under the pressure of 1 volt.)
Bulb ShapeBulb shapes are denoted with a letter, which describes the shape, and a number, which indicates the size. The number indicates the diameter of the light bulb at its widest part in eighths of an inch.
BaseThe part of the bulb that connects to the fixture and its power supply. Bulb bases are denoted with the letter E, and a number which indicates the diameter of the bulb base at its widest part in millimeters.
VoltageIndicates how much voltage a bulb can accept via the fixture it's installed in.
Light Color TemperatureThe relative color from a light source, measured on the Kelvin temperature scale. Warm light is lower in color temperature (2700-3000 K) and cool, blue light is higher (5000 K).
Average Rated LifeThe average amount time that a bulb is expected to last.
CRICRI = color rendering index. This number, which can go from 0 to 100, measures the ability of a light or bulb accurately renders colors. The higher the number, the better, with most quality bulbs these days measuring at least in the 80s.
- Fixture: Height 21.75", Diameter 10"
Manufacturer IDs: view
Need help with some of our terminology? Check out Lumens' Lighting & Design Glossary.
Related Searches and Products
The design of the simple, square Flos Ariette 1 Wall/Ceiling Mount is actually much more complex than it first appears. The two synthetic fabric panels that comprise the shade reveal an inner structure of curved red fiberglass rods. Held tautly ...
A fixture with the classic trimmings of a 19th century lamppost. The Trellis Outdoor Post Top/Pier Mount by Hinkley Lighting features a tapered clear seedy glass shade framed in Regency Bronze finished aluminum. Atop the body is a decorative, rustic ...
Traditional lantern design with a touch of modernity. The Quincy Outdoor Post Top/Pier Mount by Hinkley Lighting can fit into almost any setting with its classic Oil Rubbed Bronze finished frame and innovative dual-layered shade. The light itself takes on ...
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72W 120V A19 E26 White Halogen Bulb (2-PACK)By Satco Lighting$7.99(2){boxId:"compareuu518425", id:"uu518425"} See Comparison


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Chris Gehrz continues his series on types of Christian writing other than books by reflecting on table graces like "Come, Lord Jesus, Be Our Guest" [Read more…]
Chris Gehrz continues his series on types of Christian writing other than books by reflecting on table graces like "Come, Lord Jesus, Be Our Guest" [Read more…]
Has anyone ever collected predictions of the future of religion, whether in a book or a website? The most famous are those that predict the vast growth or decline of some faith, projections that prove to be hilariously inaccurate – eg Thomas Jefferson's view from 1822 that Unitarians would become the dominant religion in the [Read More…]
This post is gratefully re-shared from Reformation 21, where it originally ran. Like many eighteenth-century Reformed pastors, Jonathan Edwards was confident in his ability to discern God's purposes in earthly events. For example, during a 1736 drought, he explained that God was chastising New Englanders for the "corruption in our hearts." Similarly, during a plague [Read More…]
A recent e-mail conversation with Lauren Winner raised an important question – in the view of Jonathan Edwards and similar eighteenth-century evangelicals, do the emotions become more, or less, central to the Christian life as the believer proceeds in sanctification? After the resurrection, and during the millennial reign of Christ, will believers' emotions be "engaged and [Read More…]
Today's post is an excerpt from my essay on George Marsden, Jonathan Edwards, and the Art of Religious Biography, from the recently-released book American Evangelicalism: George Marsden and the State of American Religious History (Univ. of Notre Dame Press), which I co-edited with Darren Dochuk and Kurt Peterson. Biographers have put Jonathan Edwards's thought and life [Read More…]
In his magisterial biography of Jonathan Edwards, George Marsden reminds us that there was a time, in the decades after his death, when Jonathan Edwards was more popular in Scotland than in America. Indeed, there was a fleeting moment, after the Northampton church dismissed Edwards in 1750, when Edwards might have moved his family to Scotland. [Read More…]
I recently read Jonathan Yeager's excellent Enlightened Evangelicalism: The Life and Thought of John Erskine (Oxford, 2011), and am struck by Yeager's thesis that Erskine, one of the leading evangelical pastors in eighteenth-century Scotland, was especially significant as a "disseminator of enlightened evangelicalism." Of course, Erskine was also an important theologian and preacher, but where he [Read More…]
A fascinating controversy has erupted between the worlds of modern rap music and the early American Puritans, because of a song, "Precious Puritans," by Christian rapper Propaganda. For brevity's sake, I won't explore all the commentaries on the controversy, but to catch the flow of it, pastor and blogger Joe Thorn discusses the song here with [Read More…]
Our church recently hosted a presentation by Owen Strachan, who teaches theology and church history at Boyce College in Louisville, Ky. Strachan is the co-author, with Douglas Sweeney (Strachan's doctoral mentor), of the five-volume Essential Edwards Collection (2010). I happily came away from the session with a copy of one of these volumes, Jonathan Edwards on True Christianity. [Read More…]
Evangelical Christians have engaged in a robust, rancorous debate about hell in the past year. As I wrote in USA Today shortly after Osama Bin Laden's death, this debate was precipitated partly by indiscreet comments about Bin Laden's eternal destiny, and, more importantly, by the publication of Rob Bell's Love Wins. Bell's book strongly implied that because of [Read More…]
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Gender: Boy
Meaning: Fragrance
Origin: Hindi
Religion: Hindu
Parimal is a Hindu Boy name, meaning of the name is Fragrance and origin of the name is Hindi. This name is mostly used in Hindu.
If you select the name Parimal for your baby, Congratulations! But if you don't like Parimal then please continue searching our site.
External References
Similar Names


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Telstra Corporation BigPond Next-G USB Mobile Card
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Mobile Strike Cheats for Android and IOS
Mobile Strike cheats for android and Iphone? Does a hack for Mobile Strike available for free? If you are looking for a free way to get unlimited Mobile Strike gold cheat, coins and VIP you might be asking these questions yourself. The answer to the above questions is 'yes'! You can now generate free gold, coins and VIP for this game with our easy to use online generator.
Mobile Strike is one of the most popular games on google play store and in apple iTunes store. The popularity behind this game is due to the fact that its extremely fun to play.
To go higher in this game you need to buy gold,coins and VIP.However buying gold or coins all the way to higher levels is not that fun for lot of people.
This is the main reason behind our attempt to build a cheat tool for Mobile Strike game.
We wanted to build an online gold, coins and VIP generator for the game for free of charge.
We have finally launched our cheat tool with few more features that would help you advancing through the game.
New Features added to The Mobile Strike Cheats
- Generate Unlimited Gold
- Generate Unlimited Coins
- Free VIP!
- No Root or Jail Break needed
Advanced Solutions and Options – 100% Safe and Undetectable Guarantee
How to use the Mobile Strike Cheat tool to generate resources?
- Click here open the online generator.
- Enter your Mobile Strike Username.
- Select your Platform (Android, Iphone, Ipad, Ipod Touch, Kindle).
- Click Enable Encryption (This will secure your internet connection while generating resources).
- Click Connect.
- The program will connect using a simulator according to your selected platform.
- Click OK
- Now you can select the amount of gold,coins, vip you want to add
- Click Generate.
- The program will now add your selected amounts of gold to your account
- Check your Mobile Strike account and enjoy the Free gold and all the other free goodies!
Click the button below to use our Mobile Strike cheats online generator! Get yourself a super boatload of gold today!
Mobile Strike Hack
Available on iOS and Android platforms, Mobile Strike is a free-to-play 2D MMO (Massively Multiplayer Online Game) strategy game which is well known for its advertising featuring non other than Arnold Schwarzenegger. Including a gamut of features that that you could expect from any other modern mobile strategy game, Mobile Strike players can enjoy troop management, extensive base building, player coalitions and war between opposing players.
What sets this game apart from other strategy MMO's are its commander and equipment crafting systems. These allow players to customize and equip their hero with various types of armour that have been created from materials that are located from within the map. Players can level up while playing the game as well. Mobile Strike features an in-game translation service which breaks down all barriers for players from around the world, enabling them to communicate with each other despite of their language barrier.
Let's check out the Key Features of Mobile Strike
Constructing a Base – Players are able to construct a huge base area where you can build, defend and even upgrade a number of structures which in turn will push you closer to the top of the ranking board.
Crafting of Equipment – Players can make use of the materials that are found in crates and convert them in to various types of armour and weaponry which can be used by your commander.
Customizing your Commander – A player is able to level up their commander and spend all their talent points to fortify the base.
Joining an Alliance – You are able to team up with similar players, while you can lend a helping hand so that your allies can rise to the top of game's PvP ladder.
The Translator – The in-game translator allows players to chat with many players from around the world, since the language is automatically translated.
If you are new to Mobile Strike, here are a few general tips that will help you get on track with the game.
A proper focus on your mission is quite essential. After you are done with your tutorial you might wonder about taking the next step. All you have to do is go to the missions' screen where a number of recommended steps will be made available.
The most vital section is considered as the "Build" section which should be tackled from the early stages of the game. The player is able to complete a number of different upgrades and various building requests. Make sure that no section is ignored and you carry out research, manufacturing and training processes as recommended.
Do not neglect your alliance, VIP or daily missions since you will be rewarded handsomely with commander XP and resources. A tip for the ardent fans of the game would be – do not forget to go back to these sections and collect your rewards when you have completed your general and daily missions. You can also build as many resource buildings as you like since having resources will be beneficial in the long run. Also make sure that your warehouse has the capacity to meet your demand.


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Mostoslavsky R.,Harvard University |
Esteller M.,Cancer Epigenetics Group |
Esteller M.,Catalan Institution for Research and Advanced Studies |
Vaquero A.,Catalan Institution for Research and Advanced Studies |
Vaquero A.,Chromatin
Cell Cycle | Year: 2010
Longevity, lifespan, cancer, cellular transformation, energy, calorie restriction, diabetes... what can tie together such a diversity of hot topics in biomedical research? Emerging findings suggest that the answer lies in understanding the functions of the recently discovered family of proteins known as Sirtuins. Barcelona hosted the first scientific meeting completely focused on these evolutionary conserved protein deacetylases, bringing together experts in the biochemistry to cellular biology, mice models, drug targeting and pathophysiology of these molecules. Their work, summarized here, establishes the Sirtuins as major players in cellular homeostasis and human diseases that act through a whole range of biochemical substrates and physiological processes. Undoubtedly, this is an increasingly expanding field that it is here to stay and growth. © 2010 Landes Bioscience. Source
Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels
Guillaumet-Adkins A.,Imprinting and Cancer Group |
Richter J.,University of Kiel |
Odero M.D.,University of Navarra |
Sandoval J.,Cancer Epigenetics Group |
And 12 more authors.
Journal of Hematology and Oncology | Year: 2014
Background: Wilms tumor 1 (WT1) is over-expressed in numerous cancers with respect to normal cells, and has either a tumor suppressor or oncogenic role depending on cellular context. This gene is associated with numerous alternatively spliced transcripts, which initiate from two different unique first exons within the WT1 and the alternative (A)WT1 promoter intervals. Within the hematological system, WT1 expression is restricted to CD34+/CD38- cells and is undetectable after differentiation. Detectable expression of this gene is an excellent marker for minimal residual disease in acute myeloid leukemia (AML), but the underlying epigenetic alterations are unknown. Methods. To determine the changes in the underlying epigenetic landscape responsible for this expression, we characterized expression, DNA methylation and histone modification profiles in 28 hematological cancer cell lines and confirmed the methylation signature in 356 cytogenetically well-characterized primary hematological malignancies. Results: Despite high expression of WT1 and AWT1 transcripts in AML-derived cell lines, we observe robust hypermethylation of the AWT1 promoter and an epigenetic switch from a permissive to repressive chromatin structure between normal cells and AML cell lines. Subsequent methylation analysis in our primary leukemia and lymphoma cohort revealed that the epigenetic signature identified in cell lines is specific to myeloid-lineage malignancies, irrespective of underlying mutational status or translocation. In addition to being a highly specific marker for AML diagnosis (positive predictive value 100%; sensitivity 86.1%; negative predictive value 89.4%), we show that AWT1 hypermethylation also discriminates patients that relapse from those achieving complete remission after hematopoietic stem cell transplantation, with similar efficiency to WT1 expression profiling. Conclusions: We describe a methylation signature of the AWT1 promoter CpG island that is a promising marker for classifying myeloid-derived leukemias. In addition AWT1 hypermethylation is ideally suited to monitor the recurrence of disease during remission in patients undergoing allogeneic stem cell transfer. © 2014 nGuillaumet-Adkins et al.; licensee BioMed Central Ltd. Source
Guerrero-Setas D.,Cancer Epigenetics Group |
Perez-Janices N.,Cancer Epigenetics Group |
Blanco-Fernandez L.,Cancer Epigenetics Group |
Ojer A.,Cancer Epigenetics Group |
And 6 more authors.
Modern Pathology | Year: 2013
Ras association (RalGDS/AF-6) domain family member 2 (RASSF2) is a gene involved in the progression of several human cancers, including breast, colorectal and lung cancer. The aims of this study were to determine the hypermethylation of the gene in squamous cervical cancer and precursor lesions, along with that of RASSF1 and the recently described EPB41L3, and to analyze the potential prognostic role of these genes. Methylation-specific PCR and bisulfite sequencing were used to analyze the methylation status of RASSF2 and EPB41L3 gene in 60 squamous cervical cancer, 76 cervical intraepithelial neoplasias grade III, 16 grade II, 14 grade I and 13 cases of normal tissue adjacent to cervical intraepithelial neoplasia. RASSF2 expression was evaluated by immunohistochemistry and the re-expression of RASSF2 and EPB41L3 was analyzed by quantitative reverse-transcription PCR in HeLa, SiHa, C33A and A431 cell lines treated with 5-aza-2′-deoxycytidine and/or trichostatin. RASSF1 hypermethylation and human papillomavirus type were also analyzed in all the cases by methylation-specific PCR and reverse line blot, respectively. RASSF2 hypermethylation was predominant in squamous cervical cancer (60.9%) compared with cervical intraepithelial neoplasias (4.2%) and was associated with a lower level of RASSF2 expression and vascular invasion in squamous cervical cancer. EPB41L3 and RASSF1 hypermethylations were also more frequent in cancer than in precursor lesions. Patients with RASSF2 hypermethylation had shorter survival time, independent of tumor stage (hazard ratio: 6.0; 95% confidence interval: 1.5-24.5). Finally, the expressions of RASSF2 and EPB41L3 were restored in several cell lines treated with 5-aza-2′-deoxycytidine. Taken together, our results suggest that RASSF2 potentially functions as a new tumor-suppressor gene that is inactivated through hypermethylation in cervical cancer and is related to the bad prognosis of these patients. © 2013 USCAP, Inc. All rights reserved. Source
Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
Jacobsen S.C.,Steno Diabetes Center |
Brons C.,Steno Diabetes Center |
Bork-Jensen J.,Steno Diabetes Center |
Ribel-Madsen R.,Steno Diabetes Center |
And 12 more authors.
Diabetologia | Year: 2012
Aims/hypothesis Energy-dense diets that are high in fat are associated with a risk of metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as recent data show altered DNA methylation of putative type 2 diabetes candidate genes in response to high-fat diets. We examined the effect of a short-term high-fat overfeeding (HFO) diet on genome-wide DNA methylation patterns in human skeletal muscle. Methods Skeletal muscle biopsies were obtained from 21 healthy young men after ingestion of a short-term HFO diet and a control diet, in a randomised crossover setting. DNA methylation was measured in 27,578 CpG sites/14,475 genes using Illumina's Infinium Bead Array. Candidate gene expression was determined by quantitative real-time PCR. Results HFO introduced widespread DNA methylation changes affecting 6,508 genes (45%), with a maximum methylation change of 13.0 percentage points. The HFO-induced methylation changes were only partly and non-significantly reversed after 6-8weeks.Alterations inDNAmethylation levels primarily affected genes involved in inflammation, the reproductive system and cancer. Few gene expression changes were observed and these had poor correlation to DNA methylation. Conclusions/interpretation The genome-wide DNA methylation changes induced by the short-term HFO diet could have implications for our understanding of transient epigenetic regulation in humans and its contribution to the development of metabolic diseases. The slow reversibility suggests a methylation build-up with HFO, which over time may influence gene expression levels. © Springer-Verlag 2012. Source
A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice
Liechtenstein T.,University of London |
Liechtenstein T.,Immunomodulation Group |
Perez-Janices N.,University of London |
Perez-Janices N.,Cancer Epigenetics Group |
And 12 more authors.
Oncotarget | Year: 2014
Myeloid-derived suppressor cells (MDSCs) exhibit potent immunosuppressive activities in cancer. MDSCs infiltrate tumors and strongly inhibit cancer-specific cytotoxic T cells. Their mechanism of differentiation and identification of MDSC-specific therapeutic targets are major areas of interest. We have devised a highly efficient and rapid method to produce very large numbers of melanoma-infiltrating MDSCs ex vivo without inducing tumors in mice. These MDSCs were used to study their differentiation, immunosuppressive activities and were compared to non-neoplastic counterparts and conventional dendritic cells using unbiased systems biology approaches. Differentially activated/deactivated pathways caused by cell type differences and by the melanoma tumor environment were identified. MDSCs increased the expression of trafficking receptors to sites of inflammation, endocytosis, changed lipid metabolism, and up-regulated detoxification pathways such as the expression of P450 reductase. These studies uncovered more than 60 potential novel therapeutic targets. As a proof of principle, we demonstrate that P450 reductase is the target of pro-drugs such as Paclitaxel, which depletes MDSCs following chemotherapy in animal models of melanoma and in human patients. Conversely, P450 reductase protects MDSCs against the cytotoxic actions of other chemotherapy drugs such as Irinotecan, which is ineffective for the treatment of melanoma. Source


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Sunday, October 25, 2009
How to paint hyenas (miniatures)
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Dave Grohl Doc Sound City Screens at River Oaks January 31
For one night only, Dave Grohl's Sound City flick will screen at the Landmark River Oaks on January 31. Tickets should be available for pre-sale on the Landmark site very soon.
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exchange4media News Service | Oct 06, 2016
Bansal's expertise will be leveraged to buttress Swiggy's rapid rise as a leader in the food tech sector
exchange4media News Service | Aug 23, 2016
Speaking at a company townhall, Sachin Bansal sought to allay employee fears about the company's performance over the past year and a half as well as reassure employees disgruntled with the recently announced layoffs
exchange4media News Service | Jul 18, 2016
The contract will be a year long association with researches covering markets across India, and would mark the first in a series of contracts expected to be signed with the company
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In a development that came as a surprise to many, Flipkart's Mukesh Bansal, Head of Commerce & Advertising and its Chief Business Officer, Ankit Nagori have put in their papers
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With more than 15 years of experience in product development and management, Kenghe co-founded and led product management for Google Chromecast
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Hari Vasudev appointed as Senior VP, Engineering, IT & Analytics for Supply Chain vertical, Anand KV as Senior VP, Customer Experience, Commerce Platform and Manish Maheshwari as VP & Head of Seller Ecosystem
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Myntra's Founder & CEO Mukesh Bansal will also head the fashion business for Flipkart and join the Board. Myntra will continue to work as an independent entity


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May 8, 2012
MARDOQUEO GUEVARA,PETITIONER,v.MAURICE JUNIOUS, WARDEN,RESPONDENT.
Petitioner brings this habeas corpus petition pursuant to 28 U.S.C. § 2254, alleging that: 1) his sentence is unconstitutional because he received concurrent sentences for multiple convictions arising out of a single act; 2) there was insufficient evidence to support his conviction of attempted extortion in Count 10; and 3) his sentence of 17 years to life for attempting to extort $25 constitutes cruel and unusual punishment. For the following reasons, the Court finds that the state courts did not err in rejecting these claims.
The following statement of facts, including the footnotes, was taken verbatim from the California Court of Appeal's decision affirming Petitioner's convictions and sentence on direct appeal:
This case arises from repeated encounters in or about December 2006 through March 2007 between [Petitioner], an admitted gang member, and the victim Rafael Merida, a street vendor.*fn1
[Petitioner] was charged by information with committing extortion (count 1), second degree robbery (count 2), and attempted extortion (counts 8, 9, 10) against Merida.*fn2
[Petitioner] was also charged with carrying a loaded, unregistered firearm (count 6). Gang enhancements were alleged as to counts 1, 2, 6, 8, 9 and 10, and firearm-use enhancements were alleged as to counts 1 and 2. The information further specifically alleged as to counts 1, 2 and 6 that [Petitioner] had previously served a separate prison term for a felony under Penal Code section 667.5, subdivision (b).
According to the three counts at issue, [Petitioner] committed attempted extortion on the following occasions: On or between December 1, 2006 and January 31, 2007 (count 8); on or between February 1, 2007 and February 29, 2007 (count 9); and on or about March 26, 2007 (count 10).
The pertinent evidence presented at trial established Merida operated a taco stand outside a liquor store at a Van Nuys intersection. Early in 2007, [Petitioner], accompanied by several other men, told Merida he was working in a territory controlled by the Mara Salvatrucha (M.S.) gang, and he would have to pay $25 in protection money or risk being killed or having his taco stand burned down by [Petitioner] and his companions. Merida was frightened, but he told [Petitioner] the taco stand did not belong to him. Merida did not pay the protection money; [Petitioner] and his companions left. (Count 8.)
In February 2007, [Petitioner] returned with several companions again and demanded the protection money, because another taco vendor was paying it. [Petitioner] also reminded Merida he already knew what would befall him if he refused to make payment. This time, Merida said the taco stand belonged to the liquor store. [Petitioner] and his companions left, again without collecting $25 from Merida. (Count 9.)
On Monday, March 26, 2007, [Petitioner] and his companions came back a third time. [Petitioner] told Merida he would have to start paying the protection money by Friday [March 30, 2007] and "this was the last time they were letting [Merida] know."
Merida testified [Petitioner] always brought a handgun with him at every encounter.
Right after his third encounter with [Petitioner], Merida contacted police, who gave Merida a microphone to wear for his anticipated meeting with [Petitioner] on Friday, March 30, 2007. Officers agreed to conduct audio and video surveillance from a van parked near the intersection of Merida's taco stand.*fn3 [Petitioner] arrived with his companions that evening, told Merida he was there for the protection money and asked if the two of them had a deal. [Petitioner] said no one would bother Merida if he made the $25 payment. Merida saw a handgun in [Petitioner]'s pocket. At one point, [Petitioner] produced the gun, yelled to a passing vehicle that it was in M.S. territory and displayed what officers at the scene recognized as an M.S. gang sign. Merida made the $25 payment. [Petitioner] left the scene, was followed by officers, and arrested.
A police officer testified as a gang expert that [Petitioner] committed the charged offenses for the benefit of M.S., his criminal street gang.
The jury convicted [Petitioner] as charged and found true the criminal street gain allegations and firearm-use allegations. In a bifurcated proceeding, the trial court found true the prior prison term allegation.
At sentencing, the prosecutor sought a state prison term of 17 years to life; defense counsel argued the proposed sentence was cruel and unusual punishment for a $25 extortion, and urged the court to dismiss the gang enhancements (§ 186.22, subd. (g)) so [Petitioner] would be eligible to receive a determinate term sentence. The trial court replied that, had it not seen the videotape, it might have been inclined to strike the gang enhancement. "But after having seen the videotape of [Petitioner] and the way he was acting . . . , the court feels that this was really an egregious violation. It may have only been $25 on this occasion, but it was an ongoing offense. [¶] [Petitioner] was very persistent in collecting this and was clearly trying to intimidate everyone . . . with his gang affiliations." The court denied the defense motion to strike the gang enhancements in the interests of justice.
The trial court imposed an aggregate state prison sentence of 17 years to life, consisting of a life term with a minimum eligible parole date of seven years for the extortion charged in count 1, plus 10 years for the firearm enhancement under section 12022.53, subdivisions (b) and (e). The court also imposed concurrent terms of 54 months (the middle term of 18 months for attempted extortion, plus a consecutive three-year criminal-street-gang enhancement) on each of counts 8, 9 and 10.*fn4 Pursuant to section 654, the court imposed and stayed sentence on count 2 for second degree robbery, and on count 6 for carrying a loaded an[d] unregistered firearm. The court dismissed the one-year prior prison term enhancement in furtherance of justice. (Lodgment No. 5 at 2-4).
The standard of review in this case is set forth in 28 U.S.C. § 2254: An application for a writ of habeas corpus on behalf of a person in custody pursuant to the judgment of a State court shall not be granted with respect to any claim that was adjudicated on the merits in State court proceedings unless the adjudication of the claim---
(1) resulted in a decision that was contrary to, or involved an unreasonable application of, clearly established Federal law, as determined by the Supreme Court of the United States; or
(2) resulted in a decision that was based on an unreasonable determination of the facts in light of the evidence presented in the State court proceeding.
28 U.S.C. § 2254(d).
A state court decision is "contrary to" clearly established federal law if it applies a rule that contradicts Supreme Court case law or if it reaches a conclusion different from the Supreme Court's in a case that involves facts that are materially indistinguishable. Premo v. Moore, 131 S. Ct. 733, 743 (2011) (citing Bell v. Cone, 535 U.S. 685, 694 (2002)). To establish that the state court unreasonably applied federal law, a petitioner must show that the state court's application of Supreme Court precedent to the facts of his case was not only incorrect but objectively unreasonable. Renico v. Lett, 130 S. Ct. 1855, 1862 (2010). Where no decision of the Supreme Court has squarely decided an issue, a state court's adjudication of that issue cannot result in a decision that is contrary to, or an unreasonable application of, Supreme Court precedent. See Harrington v. Richter, 131 S. Ct. 770, 786 (2011).
Petitioner raised all three of his claims in a petition for review in the California Supreme Court. (Lodgment No. 6.) The supreme court did not explain its reasons for denying them. (Lodgment No. 7.) The appellate court, however, did. (Lodgment No. 5.) This Court presumes that the state supreme court rejected Petitioner's claims for the same reasons the state appellate court did. The Court, therefore, looks to the appellate court's reasoning and will not disturb it unless it concludes that "fairminded jurists" would all agree that the decision was wrong. Richter, 131 S. Ct. at 786.
A. Violation of California Penal Code Section 654 Petitioner argues that his sentence for extortion and the concurrent sentences that he received for attempted extortion violate California Penal Code § 654, because he is effectively being punished multiple times for a single, indivisible course of conduct. As a result, he argues, the concurrent sentences for attempted extortion should be stayed. (Petition for Writ of Habeas Corpus ("Petition") at 5.) There is no merit to this argument.
Because a state trial court's sentencing decisions are purely matters of state law, sentencing errors are not cognizable in federal habeas corpus proceedings. Estelle v. McGuire, 502 U.S. 62, 67-68 (1991) ("[I]t is not the province of a federal habeas court to re-examine state-court determinations on state-law questions."); Lewis v. Jeffers, 497 U.S. 764, 780 (1990) ("[F]ederal habeas corpus relief does not lie for errors of state law."); Watts v. Bonneville, 879 F.2d 685, 687 (9th Cir. 1989) (holding claim based on California Penal Code § 654 is not cognizable on federal habeas review). Thus, even assuming arguendo that the trial court misapplied California sentencing law, Petitioner would not be entitled to relief unless he could show that his sentence was fundamentally unfair. Christian v. Rhode, 41 F.3d 461, 469 (9th Cir. 1994). There is no evidence to support such an argument here. Consequently, this claim does not warrant federal habeas relief.*fn5
B. Insufficiency of Evidence to Support Attempted Extortion Petitioner claims that there was insufficient evidence to support his conviction for attempted extortion on March 26, 2007, because he had not demanded money or threatened to extort money from Merida on that date. (Petition at 5.) This claim, too, is without merit.
Federal habeas corpus relief is not available to a petitioner who claims that the evidence was insufficient to support his conviction unless he can show that, considering the trial record in a light most favorable to the prosecution, "no rational trier of fact could have found proof of guilt beyond a reasonable doubt." Jackson v. Virginia, 443 U.S. 307, 324 (1979). This Court presumes, even if it does not affirmatively appear in the record, that the jury resolved any conflicting inferences in favor of the prosecution. McDaniel v. Brown, 130 S. Ct. 665, 673 (2010) (quoting Jackson, 443 U.S. at 326). Furthermore, the Court reviews insufficiency claims "with an additional layer of deference," granting relief only when the state court's judgment was contrary to or an unreasonable application of Jackson. Juan H. v. Allen, 408 F.3d 1262, 1274-75 (9th Cir. 2005).
In California, extortion is defined as the "obtaining of property from another, with his consent . . . induced by a wrongful use of force or fear . . . ." Cal. Penal Code § 518. Attempted extortion is the "attempt[], by means of any threat . . . to extort money or other property from another." Cal. Penal Code § 524. The California Court of Appeal rejected Petitioner's insufficiency claim, noting:
[Petitioner] contends the evidence is insufficient to support his conviction for attempted extortion on count 10 because there was "no testimony [he] actually made a demand for money on March 26, 2007, nor is there evidence that he made a threat to extort." According to [Petitioner], on March 26, 2007, he "simply asked [Merida] if a deal had been made and said he would return on Friday," which amounted to "'mere preparation for the commission of the crime'" on March 30, 2007. His argument is without merit.
With respect to the crime of attempted extortion, "preparation" [h]as been defined as "devising or arranging the means or measures necessary for the commission of the offense." By contrast, "[t]he attempt is the direct movement toward the commission after the preparations are made." [Petitioner]'s actions progressed well beyond the stage of mere preparation during his March 26, 2007 encounter with Merida. As he had on the two prior occasions, [Petitioner] appeared armed with a handgun and in the company of his confederates. This time, however, Merida testified [Petitioner] not only renewed his demand for payment, but imposed a deadline for Merida to comply or otherwise to suffer the previously threatened consequences. Although on this date, [Petitioner] did not expressly renew his threat to kill Merida or to destroy his business, the threat was clearly implied under the circumstances. [Petitioner]'s words and the conduct exceeded preparation and constituted unequivocal action towards the commission of the crime of extortion. The verdict on count 10 is supported by substantial evidence. (Lodgment No. 5 at 6) (citations omitted).
The Court agrees that there was sufficient evidence to support Petitioner's conviction for attempted extortion on March 26, 2007. Prior to that date, Petitioner had confronted Merida twice before and threatened he would kill him or burn down his taco cart if Merida did not pay for protection. (Reporter's Transcript ("RT") 136-49.) Both times, Petitioner brought other gang members with him and brandished a gun. Merida was obviously afraid. (RT 137.) The third time that Petitioner approached Merida, March 26th, Petitioner was again armed and again in the company of others. (RT 140-41.) Petitioner told Merida that Merida "would have to start paying on [] Friday," and that this was the "last time" that Petitioner was warning him. (RT 140, 204.) This evidence was more than enough to support Petitioner's conviction for attempted extortion on March 26th. This is particularly so in the context of the first two encounters and the fourth encounter, wherein, after Petitioner confronted Merida again, Merida paid Petitioner the money. For these reasons, Petitioner's insufficiency claim is rejected.
C. Sentence Constituting Cruel and Unusual Punishment In Ground Three, Petitioner argues that his sentence of 17 years to life "for a $25 theft with use of a weapon and for the benefit of a gang" constitutes cruel and unusual punishment. (Petition at 5-6, attachment.) This claim is without merit as well.
The Eighth Amendment, which forbids cruel and unusual punishment, contains a narrow proportionality principle that applies to non-capital sentences. Ewing v. California, 538 U.S. 11, 20 (2003). In non-capital cases, the Eighth Amendment prohibits only extreme sentences that are "grossly disproportionate" to the severity of the crime. Harmelin v. Michigan, 501 U.S. 957, 1001 (1991) (Kennedy, J. concurring); see also Lockyer v. Andrade, 538 U.S. 63, 72 (2003) ("A gross disproportionality principle is applicable to sentences for terms of years."). As a result, "[o]utside the context of capital punishment, successful challenges to the proportionality of particular sentences have been exceedingly rare." Rummel v. Estelle, 445 U.S. 263, 272 (1980); see also Andrade, 538 U.S. at 77 ("The gross disproportionality principle reserves a constitutional violation for only the extraordinary case.").
In judging the appropriateness of a particular sentence, federal courts must give state legislatures "broad discretion to fashion a sentence that fits within the scope of the proportionality principle . . . ." Andrade, 538 U.S. at 76. This includes taking into account the state's interest in dealing in a harsher manner with those who by repeated criminal acts have shown that they are simply incapable of conforming to the norms of society as established by its criminal laws. See Rummel, 445 U.S. at 276; see also Solem v. Helm, 463 U.S. 277, 296 (1983) ("[A] State is justified in punishing a recidivist more severely than it punishes a first offender."). Current norms within society also determine whether the proportionality requirement has been met. Kennedy v. Louisiana, 554 U.S. 407, 419 (2008).
The California Court of Appeal rejected Petitioner's claim that his sentence constituted cruel and unusual punishment, finding:
The length of the sentence alone does not warrant relief. (See Harmelin v. Michigan (1991) 501 U.S. 957 [mandatory sentence of life without possibility of parole for possessing 650 grams of cocaine did not violate Eighth Amendment].) For example, California's Three Strikes law is not so disproportionate that it violates the prohibition against cruel or unusual punishment. (Ewing v. California (2003) 538 U.S. 11, 25-31.) "When the California legislature enacted the three strikes law, it made a judgment that protecting the public safety requires incapacitating criminals who have already been convicted of at least one serious or violent crime. Nothing in the Eighth Amendment prohibits California from making that choice. On the contrary, our cases establish that 'States have a valid interest in deterring and segregating habitual criminals. [Citations.]" (Id. at p. 25.)
The fact [Petitioner]'s sentence might effectively be for life without the possibility of parole based on his gang affiliation and activities in this case does not render it unconstitutional. (See People v. Byrd (2001) 89 Cal. App. 4th 1373, 1382-1383 [sentence of 115 years plus 444 years to life not unconstitutional] . . . .)
[Petitioner]'s sentence did not constitute cruel and unusual punishment. (Lodgment 5 at 10-11) (parallel citations omitted).
Again, the Court agrees. Petitioner was convicted of extortion, attempted extortion, and second degree robbery committed for the benefit of a criminal street gang and while carrying a loaded firearm. (CT 175-82, 209-10.) His sentence was enhanced based on the fact that he had previously been convicted of carrying a loaded gun. (CT 206.) With that backdrop, there is nothing remotely improper or unconstitutional about this sentence. In fact, the Supreme Court has affirmed a sentence of 50 years to life for petty theft. See Andrade, 538 U.S. at 72-77 (holding consecutive 25-year-to-life sentences for shoplifting $150 of video tapes from Kmart stores was not cruel and unusual punishment); and see Taylor v. Lewis, 460 F.3d 1093, 1099-1102 (9th Cir. 2006) (holding sentence of 25-years-to-life for possession of 0.036 grams of cocaine was not an unreasonable application of the Supreme Court's proportionality standard).
Petitioner's argument that the amount of money in controversy, $25, was so insignificant as to render his sentence extreme is misplaced. Petitioner's crime did not involve an attempted theft of $25. It involved him threatening the life of a vendor for refusing to pay protection money to operate a business in territory claimed by Petitioner's gang. Petitioner was armed with a gun when he made his threats and displayed the gun at times. In addition, this was not the first time Petitioner was out in public with a loaded gun. He had been convicted of carrying a loaded gun two years earlier. Thus, his sentence was not disproportionate to the severity of his criminal conduct. See Taylor, 460 F.3d at 1098 (holding permissible consideration of harm caused or threatened to victim or society, culpability of offender, and magnitude of crime in proportionality review); see also Ewing, 538 U.S. at 26 ("Recidivism is a serious public safety concern in California and throughout the Nation."); Solem, 463 U.S. at 296 (finding higher penalties for recidivists justified).*fn6
For all these reasons, the Petition is denied and the action is dismissed with prejudice. Further, because Petitioner has not made a substantial showing of the denial of a constitutional right, he is not entitled to a certificate of appealability. See 28 U.S.C. section 2253(c)(2); Miller-El v. Cockrell, 537 U.S. 322, 336 (2003); see also Fed. R. App. P. 22(b).
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The Tortilla Industry Association (TIA) and its members were able to take advantage of an opportunity when planning for its 2011 Annual Convention and Trade Show, returning the event to its traditional September timeframe after its shift to May last year to accommodate the triennial IBIE event. Although TIA planned to hold its 22nd Annual Convention and Trade Exposition in mid-May at the Paris Hotel in Las Vegas, NV, the association was contacted late last year and offered significant incentives to help the Harrah's chain by taking advantage of an opportunity of its own to maximize use of its meeting facilities by moving dates and location for the event. "We are happy to report that in exchange for rescheduling our event back to its traditional September timeframe we were able to negotiate significant concessions that will help us provide an extraordinary value to our membership," said Jim Kabbani, TIA's executive director. As a result, TIA attendees can enjoy upgraded first-class accommodations at Caesars Palace for a discounted room rate of $89 per night. Also, the exhibit hall is larger and able to accommodate a greater number of booths and exhibitors. "We are confident that our 22nd Annual Convention at Caesars Palace is going to be our best yet," Mr. Kabbani said. TIA's Convention Committee also is working on leveraging some of these incentives into upgraded entertainment at its annual banquet and the best speakers at its education sessions.
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