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Pretty curly four leaf clover studs. Made from laser cut acrylic with hypoallergenic surgical steel posts. They are roughly 1cm wide.
About the Designer
Isette uses historic design and modern materials and production methods to create distinctive jewelry designs. I draw inspiration from the world around me - and I am fortunate that the world around me includes a 100+ year old museum collection that I'm given free reign over and a typography obsessed graphic designer husband!


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Pretend Play > Play Kitchens
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The iHOS104 features read speeds of 4x for BD-ROM, BD-R and BD-RE discs, 8x for DVD-ROM discs and 32x for CD-ROM discs along with a 2MB buffer and SATA interface.
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I am an Assistant Professor at the Informatics Department (DI) of the Faculty of Sciences, University of Lisboa (FCUL) and a researcher at the Human-Computer Interaction and Multimedia (HCIM) Research Team at LaSIGE, a research unit of the same department, where I keep striving to empower disabled people and help surpassing the barriers of accessibility, particularly in mobile contexts. I am active on FCUL Labs, which I co-founded, a cross-disciplinary group that seeks to develop and deploy products closer to the community. I received my PhD in Information Systems & Computer Engineering from Instituto Superior Técnico (IST), Technical University of Lisbon (UTL). Currently, my main research interests are on mobile accessibility for blind and motor impaired people, cognitive and communication aids for people with dementia, usable security and inconspicuous interaction.
Latest News
Honourable Mention at MobileHCI 2016
Our paper on the Effect of Target Size on Non-Visual Text-Entry presented at MobileHCI 2016 received an Honourable Mention. The paper contributes with an an understanding of the effect of target size on non-visual text input with touchscreens.
Distinguished Paper award at SOUPS 2016
Our paper on Snooping on Mobile Phones: Prevalence and Trends presented at SOUPS 2016 received the Distinguished Paper Award. The paper contributes with alarming new estimates on the prevalence of someone snooping someone else's smartphone, particularly amongst those that are younger and/or own a smartphone. These results were achieved through an indirect questioning methodology that showed to be adequate to enquiries where social desirability bias is at play. We got attention both from international (Boing Boing, Motherboard,...) and national (Público) media.
Associate Chair at ACM CHI 2017
For the fourth year in a row, I will be an Associate Chair for ACM CHI 2017. Committees have been revamped and I am very happy to be part of the Health, Accessibility and Ageing committee, which will also, for the first time, meet remotely.
Featured in Público national newspaper and Visão national magazine
Our work on enabling access to touch surfaces, from tablets to smartwatches, with a focus on Braille and vibrotactile solutions was featured in a national newspaper and a national magazine in pieces about assistive technologies for blind people.
Braille 2.1 initiative launched.
Braille 2.1 is an umbrella term for a series of international research projects that aim to bring Braille to the 21st century. We just announced our website at braille21.com, where you can browse all projects, download applications, and even source codes. This is an initiative started by researchers at the University of Lisbon, University of Dundee and Rochester Institute of Technology.
Upcoming Travel
23-24 November, Leuven, Belgium
CHI 2017 Associate Chair
Denver, USA
PhD Students
Diogo Homem Marques (co-advisor to Luís Carriço)
Inconspicuous Security on Mobile Devices
Inconspicuous Mobile Accessibility


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"Conditioning for Young Athletes" provides coaches, instructors, teachers, and parents of future sport stars the best training advice, exercises, and programs for establishing an overall fitness base and maximizing athletic development for youth. This authoritative guide includes numerous exercises that safely increase young athletes' coordination, flexibility, speed, strength, and endurance. It contains a proven regimen geared to three developmental phases, long- and short-term training plans, and specific programs for sports such as baseball, basketball, football, ice hockey, soccer, swimming, and track and field. Tudor Bompa brings you the expertise that has helped train everyone from youth athletes to Olympic champions. Together with Michael Carrera, he provides parents, teachers, and coaches with more than 182 exercises appropriate for children ages 6 to 18. These exercises take into consideration critical factors such as a child's developmental stage, motor functioning, and sex-specific considerations to ensure that the workouts do not hinder development and growth. Regardless of the sport, " Conditioning Young Athletes" has you covered with ready-to-use programs for both short-term and long-term development.
About Dr Tudor BompaTudor O. Bompa, PhD, revolutionized Western training methods when he introduced his groundbreaking theory of periodization in Romania in 1963. After adopting his training system, the Eastern Bloc countries dominated international sports through the 1970s and 1980s. In 1988, Dr. Bompa applied his principle of periodization to the sport of bodybuilding. He has personally trained 11 Olympic medalists (including four gold medalists) and has served as a consultant to coaches and athletes worldwide. Dr. Bompa's books on training methods, including "Theory and Methodology of Training: The Key to Athletic Performance and Periodization of Training for Sports," have been translated into 17 languages and used in more than 130 countries for training athletes and educating and certifying coaches. Bompa has been invited to speak about training in more than 30 countries and has been awarded certificates of honor and appreciation from such prestigious organizations as the Argentinean Ministry of Culture, the Australian Sports Council, the Spanish Olympic Committee, the International Olympic Committee, and the National Strength and Conditioning Association. A member of the Canadian Olympic Association and the Romanian National Council of Sports, Dr. Bompa is professor emeritus at York University, where he has taught training theories since 1987. He and his wife, Tamara, live in Sharon, Ontario. Michael Carrera is a certified exercise physiologist and personal trainer with vast experience as a health, fitness, and weight-loss expert. He holds a master's degree in exercise science and has trained elite athletes, including national-level swimmers and professional hockey players. His education and experience have qualified him to create and administer strength test protocols for athletes in ice hockey, soccer, figure skating, lacrosse, and swimming at the provincial and national levels. Carrera has contributed to numerous scientific journals, articles, chapters, and manuals in the areas of fitness, health, and sport conditioning. He has published two books and produced DVDs integrating spirituality with weight training and fitness. He coauthored the second edition of "Periodization Training for Sports "(Human Kinetics, 2005). Carrera is widely recognized in the media, having appeared as an expert on numerous radio and television programs, including morning shows, specialty channels, and radio. He has been a contributor in national publications such as "Men's Health, Canadian Living, Alive," and the "National Post." Carrera created and implemented corporate wellness programs and health management strategies for top Canadian companies. He has also created more than 14,000 exercise programs for health and fitness websites such as TrueStar Kids and has overseen fitness and weight-loss centers catering to women across Canada.
Details Book
|Dr Tudor Bompa
|Human Kinetics Publishers
|Data Published
|20 June 2015
|Format Book
|PDF, Epub, DOCx, TXT
|Number of Pages
|304 pages
|Age +
|15 years
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Mathematics Research
by School of Mathematical & Statistical Sciences
To listen to an audio podcast, mouse over the title and click Play. Open iTunes to download and subscribe to iTunes U collections.
Every semester, Arizona State University's School of Mathematical & Statistical Sciences hosts a seminar series featuring a wide range of topics related to mathematics.
|CleanVideoMathematical Models of Bacteriophage Parasitization of Bacteria
|presented by Arizona State University's School of Mathematical and Statistical Sciences
|View in iTunes
|CleanVideoFree Surface Problems in Fluid Dynamics
|Fluid flows in the presence of free surfaces occur in a great many situations in nature; examples include waves on the ocean and the flow of groundwater. In this talk, I will discuss my contributions to the understanding of the systems of nonlinear partial differential equations which model such phenomena. The most important step in these results is making a suitable formulation of the problem. Influenced by the computational work of Hou, Lowengrub, and Shelley, we formulate the problems in natural, geometric variables. I will discuss my proofs (most of which are joint with Nader Masmoudi) of existence of solutions to the initial value problems for vortex sheets and water waves. I will also discuss computational results, including work with Jon Wilkening on the computation of special solutions, especially time-periodic interfacial flows.
|View in iTunes
|CleanVideoConstructions Using a Compass and Twice-notched Straightedge
|"It is impossible to trisect an arbitrary angle." We (the mathematical community) have been certain of this for the past 170 years. Missing in that statement is the qualifying phrase"... using a straightedge and compass." But if we are clumsy enough to scratch our straightedge in two places, we can in fact trisect an arbitrary angle, a result that was known to Archimedes. We are equally confident in the much more modern assertion: "There is no algorithm to solve an arbitrary quintic," where the oft omitted qualifying phrase is "... using the extraction of roots." In this talk, we will give an example of a quintic whose roots are not expressible using the extraction of roots, but whose real roots are constructible using a compass and twice-notched straightedge. We will also analyze the power and limitations of these tools, and present some open questions.
|View in iTunes
|CleanVideoTurbulence Structure-dynamics and Scalar Fluctuations
|The hypothesis that the structure of high Reynolds number turbulence conists of thin shear layers, with thickness of the order of the Taylor micro scale, has been further confirmed by numerical studies by Ishihara and Kaneda of conditional statistics and local dynamics; by PIV measurements of lab experiments by Wirth and Nickels, and by further developments of the theory, especially the transport of energy into the layers leading to the generation of intense structures, on the scale ofthe Kolomogorov micro-scale. This analysis provides (for the first time?) a physically justifiable analysis for the higher moments and why these are generally less isotropic than lower order moments, eg in thermal convection. The theoretical and practical implications of the flow near and within these layers for fluctuations of temperature and other scalars are explained. Ref JCRHunt , I Eames, P Davidson,J.Westerweel, J Fernando, S Voropayev, M Braza J Hyd Env Res 2010
|View in iTunes
|CleanVideoConvex Optimization, Harmonic Analysis & Discrete Geometry
|Starting point of my talk are approximation algorithms for NP-hard problems in combinatorial optimization which are based on semidefinite programming (SDP), a recent and powerful method in convex optimization. One example is the theta number of Lovasz which provides an upper bound for the largest size of an independent set of finite graphs based on a solution of a semidefinite program. Many problems in extremal discrete geometry can be formulated in this way but for infinite geometric graphs. A famous example is the kissing number problem which goes back to a discussion of Newton and Gregory in 1692: What is the maximum number of non-overlapping unit balls that can simultaneously touch a central unit ball? To tackle this problem we generalize the theta number (and strengthenings based on SDP hierarchies) to infinite graphs which yields an infinite-dimensional semidefinite program. By using symmetries and tools from harmonic analysis it turns out that one can solve these semidefinite programs by computer giving the best known upper bounds in dimensions up to 24.
|View in iTunes
|CleanVideoAsymptotic-preserving Schemes for the Boltzmann Equation and Related Problems
|We propose a general framework to design asymptotic preserving schemes for the Boltzmann kinetic kinetic and related equations. Numerically solving these equations are challenging due to the nonlinear stiff collision (source) terms induced by small mean free or relaxation time. We propose to penalize the nonlinear collision term by a BGK-type relaxation term, which can be solved explicitly even if discretized implicitly in time. Moreover, the BGK-type relaxation operator helps to drive the density distribution toward the local Maxwellian, thus natually imposes an asymptotic-preserving scheme in the Euler limit. The scheme so designed does not need any nonlinear iterative solver or the use of Wild Sum. It is uniformly stable in terms of the (possibly small) Knudsen number, and can capture the macroscopic fluid dynamic (Euler) limit even if the small scale determined by the Knudsen number is not numerically resolved. It is also consistent to the compressible Navier-Stokes equations if the viscosity and heat conductivity are numerically resolved. The method is applicable to many other related problems, such as hyperbolic systems with stiff relaxation, and high order parabilic equations.
|View in iTunes
|CleanVideoDynamics and Control of Spreading Populations
|I will focus on two issues of spatial population dynamics. The first will be on the dynamics and spread of populations in space, which is joint work with Brett Melbourne that begins with experimental work with the flour beetle Tribolium which is then coupled with analyses of stochastic population models incorporating different sources of variability to understand highly variable spread rates. The second part of the talk will cover questions related to control of spread of invasive species.
|View in iTunes
|CleanVideoThe Equivariant Brauer Group
|In algebraic topology, we learn to associate groups Hn(T) to locally compact spaces which "count the n-dimensional holes in T". In this talk, I want to describe how to realize H3(T) as a set Br(T) of equivalence classes of certain well-behaved C* -algebras. The group structure imposed on Br(T) via its identification with H3(T) is very natural in its C* -setting. With this group structure, Br(T) is called the Brauer groupof T. Depending on your point of view, this result can be viewed either as a concrete realization of H3(T) or as a classification result for a class of C* -algebras. In the last part of the talk, I want to describe an equivariant version of Br(T) developed jointly with David Crocker, Alex Kumjian and Iain Raeburn. No prior knowledge of C* -algebras or operator algebras will be assumed.
|View in iTunes
|CleanVideoA Second Look at the Second Law of Thermodynamics
|The increase of entropy was regarded as perhaps the most perfect and unassailable law in physics and it was even supposed to have philosophical import. Einstein, like most physicists of his time, regarded the second law of thermodynamics as one of the major achievements of the field, and it entered his work in several ways. The essence of the second law is the statement that all processes can be quantified by an entropy function whose increase is a necessary and sufficient condition for a process to occur. As a fundamental physical law no deviation, however tiny, is permitted and its consequences are far-reaching. Current wisdom regards the second law as a consequence of statistical mechanics but the entropy principle, which was discovered before statistical mechanics was invented, ought to be derivable from a few logical principles without recourse to Carnot cycles, ideal gases and other assumptions about such things as 'heat', 'hot' and 'cold', 'temperature', 'reversible processes', etc. Like conservation of energy (the ``first'' law), the existence of a law so precise and so model-independent must have a logical foundation that is independent of the details of the constitution of matter. In this lecture the foundations of the subject and the construction (with J. Yngvason) of entropy from a few simple principles will be presented. (No previous familiarity with the subject is required.) A summary can be found in: "A Guide to Entropy and the Second Law of Thermodynamics", Notices of the Amer. Math. Soc. vol 45 571-581 (1998). http://www.ams.org/notices/199805/lieb.pdf. arXiv math-ph/9805005 This paper received the American Mathematical Society 2002 Levi Conant prize for ``the best expository paper published in either the Notices of the AMS or the Bulletin of the AMS in the preceding five years''. A Fresh Look at Entropy and the Second Law of Thermodynamics, Physics Today {\bf 53}, 32-37 (April 2000). arXiv math-ph/0003028
|View in iTunes
|CleanVideoGenus One Curves Over the Rationals
|We will describe what a genus one curve is and then specialize to the case of elliptic curves. After discussing a simple looking problem through which elliptic curves become objects that we want to understand, we will summarize some known results about elliptic curves. To conclude, we will go back to the general genus one curve over the rationals and see how close this object is to being an elliptic curve. Mirela Çiperiani is an Assistant Professor in the Department of Mathematics at the University of Texas at Austin
|View in iTunes
|CleanVideoTopological Symmetries of Molecules
|The School of Mathematical and Statistical Sciences presents Dr. Erica Flapan, Lingurn H. Burkhead Professor, Department of Mathematics, Pomona College presenting on the topic, Topological Symmetries of Molecules.
|View in iTunes
|CleanVideoUsing Information on Both Short-Term Response and Long-Term Survival in the Design of Oncology Clinical Trials
|We propose a new design for phase II oncology clinical trials based on two considerations. (1): Currently most phase II oncology trials use complete remission (CR) as the primary end point. The drugs having higher CR rates enter into subsequent phase III trials, which are usually required to demonstrate benefit on survival. Although achieving CR is necessary for prolonging survival, it is not sufficient because patients may relapse shortly after achieving CR. This discrepancy was one of the major reasons for the high failure rates of phase III trials. So it is desirable to evaluate survival outcomes in phase II trials. (2): Assigning more patients to the better treatment arms is more ethical than equal randomization. However, due to the long waiting time to observe the survival outcome, a response-adaptive randomization for survival clinical trials can be inefficient in skewing the randomization probabilities to favor better-performing treatment arms. A natural idea is to use the short-term response information to "speed-up" the response-adaptiveness of the randomization procedure of survival clinical trials? Based on these considerations, we propose a new phase II design that use information on both CR and survival. Their relationship is specified by a Bayesian model. This model is first constructed by using prior clinical information, and then updated continuously by the information accumulated in the ongoing trial. Comparing with a trial using only information on survival, the new design uses fewer patients and takes less time, and can more effectively assign patients to the better treatment arms. Comparing with a trial using only the information on CR, the new design is more reliable in the sense that it picks drug candidates that are more likely to succeed in subsequent phase III trials. Published in Statistics in Medicine. 28(12): 1680-1689, 2009. Free software available on https://biostatistics.mdanderson.org/SoftwareDownload/Default.aspx
|View in iTunes
|CleanVideoProject Humanities: Linguistic Issues in College Mathematics Courses
|Hosted by Professor Kyeong Hah Roh Abstract Much of what we say and write in our mathematics classes assumes that our students understand linguistic and logical conventions that have never been made explicit to them. What problems result from this assumption, and how can we address them? Biography Susanna S. Epp (Ph.D., University of Chicago, 1968) is Vincent de Paul Professor of Mathematical Sciences at DePaul University. After initial research in commutative algebra, she became interested in cognitive issues associated with teaching analytical thinking and proof and has published a number of articles and given many talks related to this topic. She is the author of Discrete Mathematics with Applications, now in its fourth edition, and of the newly published Discrete Mathematics: An Introduction to Mathematical Reasoning. She also co-authored the first edition of Precalculus and Discrete Mathematics, which was developed as part of the University of Chicago School Mathematics Project. Long active in the Mathematical Association of America, she is a co-author of CUPM Curriculum Guide 2004. In January 2005 she received the Louise Hay Award for contributions to mathematics education, and in April 2010 she received the Award for Distinguished Teaching of Mathematics from the Illinois Section of the Mathematical Association of America.
|View in iTunes
|CleanVideoRobust Rational Interpolation
|Approximating functions or data by polynomials is an everyday tool, starting with Taylor series. Approximating by rational functions can be much more powerful, but also much more troublesome. In different contexts rational approximations may fail to exist, fail to be unique, or depend discontinuously on the data. Some approximations show forests of seemingly meaningless pole-zero pairs or "Froissart doublets", and when these artifacts should not be there in theory, they often appear in practice because of rounding errors on the computer. Yet for some applications, like extrapolation of sequences and series, rational approximations are indispensable. In joint work with Pedro Gonnet and Ricardo Pachon we have developed a method to get around most of these problems in rational interpolation and least-squares fitting, based on the singular value decomposition. The talk will show many examples of the performance of our "ratdisk" code, including an application to radial basis function interpolation.
|View in iTunes
|CleanVideoMathematics and Mathematics Education: An Excursion into the Affective Domain
|I am an active mathematical physicist who has also engaged long-term with mathematics education; particularly, with research on mathematical learning and problem solving. This led, perhaps inevitably, to a focus not only on cognition, but also on the psychology of what is called "the affective domain" – i.e., emotional feelings, attitudes, beliefs, and values – in relation to mathematics. In this talk, I shall discuss some important affective constructs which relate directly to mathematical teaching and learning, with a particular focus on the nature of student engagement. Among the ideas considered are the importance of emotional feelings during mathematical problem solving, the idea that information important to learning is encoded affectively (interactions with cognition), the role of beliefs about mathematics, students' (longer-term) motivational orientations, and various "in the moment" motivating desires that can foster (or inhibit) students' mathematical engagement, as well as difficulties that arise in efforts to study mathematical affect. Some broader implications are suggested for how we prepare mathematics teachers, how we connect with our own students, and how we represent mathematics to the wider community.
|View in iTunes
|CleanVideoGroup Actions, Labelled Graphs, and C* -Algebras
|This presentation does not require previous knowledge of C*-algebras, labeled graphs, or group actions. A labeled graph over an alphabet consists of a directed graph together with a labeling map . One can associate a C*-algebra to a labeled graph in such a way that if the labeling is trivial then the resulting C*-algebra is the C*-algebra of the graph . In this presentation, I will discuss joint work with Teresa Bates and David Pask concerning (discrete) group actions on labeled graphs and the resulting crossed product C*-algebras. In particular, I will discuss our main theorem which shows that the crossed product that arises when a group acts freely on a labeled graph is strongly Morita equivalent to the C*-algebra of the quotient graph of the action. I will focus on the two major ideas needed to prove this Morita equivalence. The first is a generalization of the so-called Gross-Tucker theorem, which shows that a free labeled graph action is naturally equivariantly isomorphic to a skew product action obtained from the quotient labeled graph. The second is a generalization of a theorem of Kaliszewski, Quigg, and Raeburn to the e ect that the C*-algebra of a skew product labeled graph is naturally isomorphic to a co-crossed product of a coaction of the group on the C*-algebra of the labeled graph.
|View in iTunes
|CleanVideoRadial Basis Functions for Computational Geoscience
|Current community models in the geosciences employ a variety of numerical methods from finite-difference, finite-volume, finite- or spectral elements, to pseudospectral methods. All have specialized strengths but also serious weaknesses. The first three methods are generally considered low-order and can involve high algorithmic complexity (as in triangular elements or unstructured meshes). Global spectral methods do not practically allow for local mesh refinement and often involve cumbersome algebra. Radial basis functions have the advantage of being spectrally accurate for arbitrary node layouts in multi-dimensions with extreme algorithmic simplicity, and naturally permits local node refinement. We will show test examples ranging from vortex roll-ups, modeling idealized cyclogenesis, to the unsteady nonlinear flows posed by the shallow water equations to 3-D mantle convection in the earth's interior.
|View in iTunes
|CleanVideoAcquisition of Mathematical Concepts: What Instantiations Promote Transfer of Conceptual Knowledge?
|Mathematical concepts are often difficult for students to acquire. This difficulty is evidenced by failure of knowledge to transfer from the learning situation to a novel isomorphic situation. What choice of instantiation most effectively facilitates successful transfer? One possibility is that grounding the concept through a concrete, contextualized instantiation may facilitate learning and in turn facilitate transfer. On the other hand, several cognitive factors influence the process of analogical transfer suggesting that facilitating transfer may depend on more than promoting initial learning. A series of experiments examined learning and transfer when students learned instantiations of a simple mathematical concept that were either concrete/ contextualized or abstract/ generic. I discuss these findings in detail, specifically the underlying cognitive mechanisms involved in analogical.
|View in iTunes
|CleanVideoAlgebraic Statistics
|Algebraic statistics advocates polynomial algebra as a tool for addressing problems in statistics and its applications. This connection is based on the fact that most statistical models are defined either parametrically or implicitly via polynomial equations. The idea is summarized by the phrase "Statistical models are semialgebraic sets". I will try to illustrate this idea with two examples, the first coming from the analysis of contingency tables, and the second arising in computational biology. I will try to keep the algebraic and statistical prerequisites to an absolute minimum and keep the talk accessible to a broad audience.
|View in iTunes
|19 Items
Customer Reviews
Great titles (and probably lectures, too) but unwatchable.
I've only tried watching "Constructions with a Compass…," "Group Actions, Labelled Graphs,…," and "A Second Look at the Second Law of Thermodynamics," but all three suffer from being far too quiet. Too bad...
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Today, I bought a live lobster to have for dinner. When my four year old daughter discovered it in the cooler, she thanked me incessantly for finally getting her a pet. She now won't let "Mr. Shelly" out of her sight. FML
by meganmagee / 09/16/2013 at 2:47pm / United States (Georgia) / Kids
Today, my son asked me if slavery was ever abolished. He's 19. FML
by Anonymous / 09/16/2013 at 1:42pm / United States (New York) / Kids
Today, my mum got engaged to her American pen-pal, who is in prison over there for murder. FML
by Stheno / 09/16/2013 at 8:49am / United Kingdom (Bristol, City of) / Love
Today, I told my boyfriend I loved him. He told me he was a dinosaur. FML
by Kit / 09/16/2013 at 7:09am / United Kingdom (Swindon) / Love
Today, I walked in the bathroom to find my son cleaning his penis. It wouldn't have been so bad if he wasn't cleaning it with a toothbrush. FML
by clean / 09/16/2013 at 3:51am / Australia (New South Wales) / Kids


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For optimal performance of MERLOT functionality, use IE 11 or higher, or Safari on iOS mobile devices
I have used an activity similar to this in my Practical Accounting classes. I will try to schedule one class period for the activity (a class lasts 80 minutes) and try to set up the boards before students come to class. This allows for the maximum time possible for playing the game. I will also slip in a Monopoly day if we get through a chapter in fewer days than scheduled. Once students have played the game once, they will often ask when another opportunity to play can be arranged.
This activity gives each student a chance to analyze a unique set of transactions. I also encourage the students to help each other work through the tougher transactions (paying someone for a vote or winning a beauty pagent). In class, students are only required to journalize the transactions that affect them as the game is played. Outside of class, they post the transactions to the ledger and prepare an income statement, statement of owner's equity, and a balance sheet. I use instructions that are similar to those provided with this material.


text: 1 photos $875,000 97.48 acres 5000 sqft 2701 GOLF COURSE, Marlette, MI 48453 - Sanilac County 97.48 acres Marlette, MI USGA rated 9 hole golf course in Marlette. There is enough land to make it an 18 hole course. Located on M-53 (class A road) with easy access. 5000 square foot facility has up to date kitchen and large banquet room- seats 140. Banquet room is separate from the bar (seating capacity 50) or the large sliding doors can be opened to connect the bar to the banquet room. Lots of possibilities. Lottery license. Facility has 2 sets of bathrooms pro shop and large deck for out door dining during the warmer months. Steel roof is new - 2016. Comes with trade fixtures and class C liquor license golf carts and maintenance machinery and a large building for storage.


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Zimmermann - Brake Discs manufactured in Germany!
You profit by our competence in braking.
It is our goal to always offer our partners and customers a high quality product together with an excellent service. As a manufacturer of safety components, we are aware of our responsibility and put the greatest emphasis on product quality. Read more »
Merry Christmas!
The entire team of Zimmermann wishes you a peaceful Christmas Season and a hopeful New Year. Our company will be closed for holidays from December 24th until January 2nd. We are looking forward to an ongoing prosperous cooperation in 2017.


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Established in the early 1980's, Cales & Co are the oldest established agent covering our catchment area. We believe our success is attributable to enthusiastic & dedicated teamwork, and commitment to all customers old and new.
Buying and Selling
Our independently owned business offers a full range of Properties for Sale or rent across a range of Prices. Our Clients can expect a professional service with a personal touch.
Our thorough knowledge of the local areas, combined with many years of experience, help us to sell more properties. We consider every house and their owner to be individual and treat them accordingly.
We will provide you with a draft copy of your QUALITY COLOUR sales particulars for your perusal. These particulars will be compiled to present your home to the best possible standard in order to attract as many potential purchasers as possible. For the benefit of both vendor and estate agent, obligations under the Property Misdescription Act 1991 will be rigorously complied with. We will also encourage any additions or amendments you may wish for in accordance with the aforementioned act.
We enjoy considerable exposure in the local media with coverage in the Evening Argus providing coverage throughout East and West Sussex. This amounts to a circulation of over 250,000 readers. Our established contacts with the local and regional press can at times provide further media coverage of an editorial nature.
Sale Boards
Our widely recognized 'FOR SALE' boards are renowned for providing effective enquiries for our clients' homes and are distinctive in design. In any market place it is imperative that every opportunity is taken to promote the sale of a property with the aim of reaching the maximum number of potential purchasers. Therefore with this in mind, and unless otherwise instructed we would erect a 'For Sale' board in the most prominent position available.
We would never encourage chance callers for obvious security reasons. In the majority of cases, a member of staff will accompany prospective purchasers however; if due to prior arrangements we are unable to attend we will offer to arrange an alternative appointment.
Opening Times
Our offices are open from 9.00am to 6.00pm Mondays to Fridays and from 9.00am to 4.00pm on Saturdays.
48 Boundary Road, Hove, BN3 4EF


text:
ImmuCell CorporationNASDAQ
PRO Research
ImmuCell Corporation: A Cheap Biotech With Upcoming FDA Approval Catalyst
Boris Marjanovic • 26 Comments
Boris Marjanovic • 26 Comments
Thu, Nov. 10, 4:22 PM
- ImmuCell (NASDAQ:ICCC): Q3 EPS of $0.01
- Revenue of $2M (-20.0% Y/Y)
- Press Release
Tue, Oct. 18, 12:53 PM
Tue, Oct. 18, 11:01 AM
Tue, Oct. 18, 9:02 AM
- ImmuCell (NASDAQ:ICCC) enters into agreements with institutional investors for the direct placement of 659,880 shares of common stock at $5.25, representing a 32.5% discount from yesterday's close of $7.7801. No warrants are being offered.
- Proceeds will help fund capex.
Thu, Aug. 11, 4:13 PM
- ImmuCell (NASDAQ:ICCC): Q2 EPS of $0.00
- Revenue of $2.4M (+22.4% Y/Y)
- Press Release
Wed, May 11, 4:22 PM
- ImmuCell (NASDAQ:ICCC): Q1 EPS of $0.11
- Revenue of $3M (-3.2% Y/Y)
Mon, Mar. 7, 4:09 PM
- In a regulatory filing, ImmuCell (NASDAQ:ICCC) discloses that its auditor, Baker Newman & Noyes, LLC, (BNN) informed it that it will not submit a bid for the company's auditing needs for 2016. BNN believes a larger accounting firm with experience in the industry and SEC reporting would be a better fit considering the company's growth plans.
Wed, Feb. 10, 4:13 PM
- ImmuCell (NASDAQ:ICCC): Q4 EPS of $0.09
- Revenue of $2.7M (+22.7% Y/Y)
Fri, Jan. 29, 12:44 PM
Fri, Jan. 29, 6:57 AM
- On a preliminary basis, ImmuCell (NASDAQ:ICCC) expects 2015 EPS of $0.34 - 0.41 on revenues of ~$10.2M. Its cash and investments at year end totaled ~$6.5M.
- It has also initiated a public offering of common stock. Price, volume and terms have yet to be announced.
- ICCC is down 16% premarket but only on turnover of 410 shares.
- Update: In a regulatory filing, the company discloses that its equity offering is 1,123,810 shares of common stock at $5.25 per share. Net proceeds of ~$5.3M will fund the construction and equiping of a facility that will produce Nisin, the active ingredient in the company's Mast Out product for the treatment of subclinical mastitis in lactating dairy cows.
Nov. 13, 2015, 12:48 PM
Nov. 12, 2015, 4:23 PM
- ImmuCell (NASDAQ:ICCC): Q3 EPS of $0.11
- Revenue of $2.5M (+38.9% Y/Y)
Aug. 13, 2015, 4:14 PM
- ImmuCell (NASDAQ:ICCC): Q2 EPS of $0.03
- Revenue of $2M (+29.9% Y/Y)
Jul. 8, 2015, 9:09 AM
- Citing a better-than-expected inventory production schedule that allowed it to address pent-up demand for First Defense, ImmuCell (NASDAQ:ICCC) ups its Q2 revenue growth forecast to 25 - 30%, up significantly from its previous projection of a decline of 15 - 20%. H1 sales should be 40% higher yoy.
- The company remains on track to complete its planned manufacturing capacity expansion by Q1 2016.
May 13, 2015, 11:59 AM
- Thinly traded nano cap ImmuCell (ICCC +35.2%) jumps on a 17x surge volume, albeit on turnover of only 113K, in response to its announcement of Q1 results after yesterday's close. It was the firm's most profitable quarter in 12 years.
- Sales were up 49% while its First Defense scours treatment for calves grew 62%. Net income was $479K or $0.15 per share.
- The company develops products that improve animal health and productivity in the dairy and beef industries.
May 12, 2015, 4:46 PM
- ImmuCell (NASDAQ:ICCC): Q1 EPS of $0.15
- Revenue of $3.1M (+47.6% Y/Y)
- Shares +5.7%.


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Vince Luecke
editor@perry countynews.com
I grew up ankle-deep in hog manure. Well, I had boots on, but I got plenty of pig and cow poo on me and when I had to clean out the chicken house, I breathed in my share of dried chicken poo, too.
Other than obesity (which genes and my overactive appetite are to blame) I'm healthy and don't have allergies or asthma. So are my siblings and as I've thought about it the past couple of weeks, so are most of the one-time farm kids I know.
Now that the election is over and the dust of arguably the most contentious presidential race in our history has finally settled, revealing a clear and decisive winner, everyone should just calm down.
There have been thousands of protesters rioting in cities across the country who decry Hillary Clinton's defeat at the hands of now President-elect Trump.
By LARRY GOFFINET
Sports Editor
TELL CITY – Area residents should find free books to read at two Perry County Parks next spring thanks to a Perry Central student's class project.
Cori Allen, a sophomore at Perry Central, told the Perry County Parks and Recreation Department's board Wednesday that for her AP language group community project she wants to install little free libraries at Riverside Park in Magnet and Wilkerson Park in Rome "to make reading more accessible throughout the community."
By JAKE BETHEL
Feature Writer
TELL CITY – Upgraded cell phone service is one step closer to reality for Tell City.
PBM Wireless Services of Carmel, on behalf of Verizon Wireless, is prepared to erect a cell phone tower on property owned by Mulzer Crushed Stone located along Sixth and Lafayette streets. The tower could improve both data and calling services for cellular customers. Currently, the closest tower is on North Ridge Road, just outside city limits.
Staff Writer
With a customer comfortably situated in an adjustable chair, artist Zach Kalin's supplies are neatly laid out on a tray within easy reach. Head down, hard at work, Kalin has already drawn out the concept. The only thing left is application.
By STUART CASSIDY
TELL CITY – Come the New Year, patrons to the Perry County Courthouse will likely be greeted by a new face; not one filling an elected position, but instead to ensure safety. The county commissioners recently announced plans to add a security guard stationed at the front entrance.
Bristow United Pentecostal taking candy orders
BRISTOW – Bristow United Pentecostal Church is now taking candy orders for Thanksgiving.
All orders must be in by Friday, Nov. 18, and delivery will be on Monday, Nov. 21.
Candy available is: plain fudge, fudge with walnuts, peanut butter fudge, peanut butter balls (Buckeyes), and peanut brittle. Fudge and Buckeyes are $7 per pound: they can also be ordered in 1/2 pound sizes.
TELL CITY – Joe Baxter of Tell City scored his third hole-in-one and second at Hoosier Heights Country Club on the 125-yard, par-3 seventh hole Monday.
Hugh Clayton witnessed the shot.
Baxter, 79, also shot better than his age that round, finishing with 78 for 18 holes.
By LARRY GOFFINET
Sports Editor
TELL CITY—Leo Simpson was named Tell City's boys cross country Most Valuable Runner for the third year in a row at the school's fall sports awards program Monday.
That award was based strictly on points scored.
No Most Valuable Player award was given in volleyball but Emma Kohnert, who was named MVP last year, won the Offensive Player of the Year award in that sport.
Morgan Schuetter won the volleyball Defensive Player of the Year award.
Copyright © 2016
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


text:
Growing Vancouver Veterinary Practice For Sale. Annual Collections over $1.1 million per year. Located in a stand-alone building with high visibility and traffic counts. Over 1,000 patient visits per month with approximately 45 new clients per month. Real Estate is also for sale.
Financials (USD)
Asking Price Between $500,000 and $1,000,000
Sales Between $500,000 and $1,000,000
Profit Between $1,000,000 and $2,500,000
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Vet Practice South Eastern Washington #391916 posted Oct 13, 2015
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Southeastern Washington. Small Animal Practice in Wine country in the Tri-Cities area. Small town setting, Large town Cash flow with Production of $400k, Cash flow of $165k open 4 days a week! Good location on an Acre Lot, Real estate Included! Lots of options for expansion if desired.
Feline Veterinary Clinic for Sale in Lane County #388782 posted Aug 28, 2015
- Eugene, Oregon, United States
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Feline clinic. Lane County. Annual average collections of $745,000 with 1.5 to 2 doctors. Located on a busy street near the University. Possible Real Estate available- Contact for details.
Tacoma Small Animal Practice for Sale #404449 posted Apr 6, 2016
- Tacoma, Washington, United States
- Between $500,000 and $1,000,000
Small animal practice with solid client base. A full service companion animal hospital commitment to provide quality veterinary care throughout the life of a pet. Currently 3 veterinarians and professional staff assist with routine preventive care and treatment of disease. Hospital provides the highest...
Did you know that social networking is a great way to buy a business? Sign up now and we'll show you how.
Disclaimer: MergerNetwork has not independently verified any of the information in this listing and makes no warranty as to its accuracy or completeness.


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- Autor: WADSWORTH, MELANIE
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Join Sam and Gabriel Brown as they experience their honeymoon away from Garamount. Their first stop is in the historic and sacred Land of Gaywas where the native traditions and hidden treasures offer Sam the peace of mind she seeks. Here she discovers Gabe through the eyes of others and learns more about him and herself in the most unexpected way. When they leave the Land of Gaywas, they appear to be typical newlyweds on their honeymoon, but everything takes a drastic turn quickly for them as well as those they love and left behind in Garamount. Follow Sam as she discovers the nuances of her inherited gift; the pleasures of being married to a man like Gabe; and the burden of being more than she would have ever dreamed. And delve into the mysteries that are disturbing Garamount's serenity. Part Two of Sam and Officer Gabriel Brown's intense love story leaves the reader delighted and desperately eager as they vicariously discover the truths behind what makes Sam so unique and how she is endangering the life of her beloved new husband.


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6-in-1 Handheld Steamer£19.99 instead of £59.95 for a 6-in-1 electric handheld steamer from Wowcher Direct - save 67% + DELIVERY IS INCLUDED!
Save 67%
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- Get a 6-in-1 handheld steamer.
- Remove dirt, grease and more without cleaning chemicals.
- Valid in blue, pink, red and yellow.
- Attachments inc. door and window nozzle, funnel, extension and more.
- Delivery is included!
The Fine Print
- May buy multiples.
- Voucher valid until 17th April 2014.
- Please allow up to 10 working days for delivery after redeeming.
- Subject to availability.
Full Details
Starting to think all these 'miracle' cleaning products are just a load of hot air? Well, let today's steamin' deal show you otherwise...
We're offering you a 6-in-1 electric handheld steamer for just £19.99, which saves 67% compared to Snagabargain's price of £59.95 (correct as of 28.3.14).
Most of the time, elbow grease is all you need to get the house looking spic-and-span, but unfortunately finding someone with a decent supply of elbow grease is a tricky business. Designed to remove adhesive, grease, dirt, grit and more, this highly pressurised steamer is all you need to make light work of those cleaning duties. This handy gadget comes in blue, pink, red and yellow and has the following attachments:
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2hr Falconry Experience for 1 or 2£16 instead of £60 for a two-hour falconry experience for one person, £29 for two people at Simon Tebbutt Falconry, Oakham - save up to 73%
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Hydration for Health
According to the U.S. Geological Survey, approximately 71 percent of the earth's surface is composed of water. Similarly, 60 to 70 percent of the average adult human body is composed of water. If ...View Article
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For more information or to schedule an appointment with our Highland Park chiropractor, call 732-246-4242 today!
The Highland Park & Princeton Chiropractors For Your Family!
Dr. Wayne Rebarber and Dr. Kim Oman enjoy helping Highland Park and Princeton-area patients with today's safe and natural chiropractic care. Chiropractic can treat so much more than just your traditional back and neck pain. Chiropractic helps alleviate the symptoms you may be experiencing from a condition you wouldn't normally associate with the spine. Our goal here at Rebarber Family Chiropractic is to help you get well and stay well!
The Rebarber Family Chiropractic team find it not only emotionally fulfilling, but also humbling when they get to help others with regular chiropractic care. They get to witness chiropractic miracles every day. Will yours be their next?
We can explain how chiropractic produces results the natural way without drugs or surgery. If you are interested in learning more, call our Highland Park chiropractic office! We look forward to hearing from you!
If you are new to seeing a chiropractor and want to find out more, please email us or call 732-246-4242 to receive personalized answers to your questions from our friendly team. We also welcome referrals, so feel free to use the "Send to a Friend" link located at the bottom of every page to share our health information with your friends and loved ones.
If you would like to stay informed about modern chiropractic care or if you want to start receiving free articles about health and wellness news, please subscribe to our bi-weekly newsletter, even if you are not a patient. Once you are subscribed, you will be able to explore our member wellness section and take advantage of our animated exercise videos, wellness articles, and other resources.
Dr. Wayne Rebarber
Dr. Kim Oman
Highland Park and Princeton as | Rebarber Family Chiropractic | 732-246-4242
307 Raritan Ave
Highland Park, NJ 08904
812 Route 206
Princeton, NJ 08540
Featured Articles
According to the U.S. Geological Survey, approximately 71 percent of the earth's surface is composed of water. Similarly, 60 to 70 percent of the average adult human body is composed of water. If ...View Article
Mindfulness has become a very hot topic and is now consistently featured in mass media. This may be considered a good thing, as more and more of us allow ourselves to become distracted throughout ...View Article
Regardless of the type of weather, meteorological events have a big impact on all of us. Beyond the sunscreen, floppy hats, raincoats, umbrellas, snow shovels, and de-icers, there are the physiolo ...View Article
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Grace is a quality we instinctively recognize in many ballet dancers, medal-winning gymnasts, and professional athletes. The best of these top-level performers not only possess split-second, real- ...View Article
Many of us are continually amazed at the frequency with which professional baseball players suffer season-threatening muscular injuries. There they are, running hard down the first base line tryin ...View Article


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|Property type
A great touring base. Explore the rugged north coast, visit the Tate Modern Gallery or enjoy afternoon tea in St Ives.. This barn conversion, adjoining the owner's home, is set in a peaceful rural location within easy reach of the rugged north coast, which is popular with surfers, walkers and bird/wildlife enthusiasts. The property is approached by an unmade private lane and is set in a small hamlet of properties, on the site of Chown China Pottery. This is the perfect holiday spot for couples looking to relax and explore the diverse Cornish coastline and countryside. The area is great for walking and is within easy reach of the A30, where guests can visit any of the major resorts within a 15-30 minute drive, including Hayle, St Ives, Gwithian, Marazion and Penzance. Take the scenic coastal train from nearby St Erth to St Ives, passing the Hayle Estuary and some of the area's most beautiful beaches. St Ives is famous for its glorious light, and attracts artists from around the world. Stroll along the water's edge and enjoy afternoon tea or a meal al-fresco. Visit the Tate Modern Gallery or the Barbara Hepworth Museum. Godrevy Lighthouse, perched on a small island, is a haven for seals and bird life, and overlooks the wide beaches of Gwithian and Hayle, with over 3 miles of beach and sand dunes to explore. Perfect for sun bathing, and equally invigorating on a winter's day for a blustery walk with the dog. Tehidy Country Park offers nature trails, cycle and bridle paths, and wonderful woodland walks. Beach 2 miles. Shop, pub and restaurant 2 miles.. Step down to entrance. All on ground floor: Step down to kitchen/dining area/living room with double bed. Shower room with toilet. Tiled floors throughout.. Ground source underfloor central heating, electricity and bed linen included. Freeview TV. DVD. Electric cooker. Microwave. Fridge/freezer. Wi-fi. Small enclosed patio and sitting-out area. Parking (1 car). Welcome pack. Pets to be kept on a lead - working farm. No smoking.
*Plus compulsory or optional charges based on actual occupancy or consumption. The payment has to be made in the currency offered by the property manager, before use of conversion tool. Payments in other currencies have to be negotiated beforehand with the property manager. The currency conversion tool is provided for your convenience only and is non-binding.


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Based on a 2,000 calorie dietSee full nutrition
Ready In
It was easy and really tasty. I made aome sauce with the dressing and added some veggies on the side. Wonderful! thanks for the recipe
Loved it! It was mild and accented the Mahi flavor nicely. I will definitely be using it again.
Awesome, awesome, awesome! Loved this! Made it with 2 Mahi Mahi filets and had marinade left over, so I mixed it in with my rice. I had to broil it, though, because it was raining when I made...
It is always a challenge to find a meal all five of us like. All five of us loved this recipe. My sons loved the sauce and we ate every piece of Mahi Mahi. it was easy and delicious. Thank you...
My husband and I really liked this! Easy and uses ingredients that we always have around. The recipe made more sauce than we really needed for the 2 of us so it could even be cut down a bit. Tha...
This was very good! I used 3 garlic cloves, because we love our garlic.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jun 16, 1998
|Filing date
|Aug 23, 1996
|Priority date
|Aug 23, 1996
|Fee status
|Publication number
|James A. Halamek, Mark J. Loncar, Rao P. Gullapalli
|Original Assignee
|Picker International, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (14), Non-Patent Citations (16), Referenced by (11), Classifications (9), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to the magnetic resonance imaging art. It finds particular application in conjunction with respiratory motion compensation in segmented k-space imaging sequences and will be described with particular reference thereto. However, it is to be appreciated that the invention will also find application in conjunction with other types of motion compensation and with different k-space segmentation.
In segmented k-space imaging, k-space is divided into a selected number of segments. Each resonance excitation or shot of a multiple echo imaging sequence, such as fast spin echo or echo planar imaging, is followed by a plurality of echoes commensurate with the number of segments of k-space. Each echo of the echo train generates a data line for a corresponding one of the segments of k-space. For example, the echo closest to excitation is sometimes phase-encoded to generate the data line for the segment closest to the center of k-space, the echo further from the excitation generates that data line in the segment with the largest positive or negative phase-encode angles, etc. In each repetition, a data line for each segment of k-space is generated.
One of the disadvantages of the segmented k-space approach is that one often ends up with coherent ghosts in the image. Worse, the ghosts appear at unpredicted locations, creating uncertainty whether the ghost is part of the actual image or whether it is actually an artifact.
In another technique for reducing breathing motion, two or three interleaved data sets are generated from the same region of the body in a way that the phase of the ghost component is related to the phase of the quasi-periodic motion, while the magnitude of the ghost component and both the phase and magnitude of the image component are not. Post-processing of the two or three data sets is utilized to extract the image portion of the data and cancel the ghosts.
In non-segmented k-space imaging sequences, such as a simple spin echo sequence, the order of the phase-encoding has been controlled to reduce motion artifacts. In the ROPE technique, the phase-encoding are randomly ordered. In the COPE technique, the phase-encoding is centrally ordered, i.e., the best, most motion-free data is phase-encoded to fall near the center of k-space. In the POPE technique, the phase-encoding is projection ordered. The ROPE and POPE techniques tend to make the data look monotonic; whereas, the COPE technique tends to make the data look like a centrally symmetric period.
One disadvantage is the long data acquisition times to acquire 2 or 3 interleaved data sets, typically 2-3 times as long. Moreover, a significant amount of post-processing is required to produce the final images.
Another technique for reducing motion artifacts is to interrupt data collection during periods of peak motion, i.e., respiratory gating. That is, data collection is enabled only when there is substantially no respiratory movement and prevented from occurring when there is significant respiratory movement.
Respiratory gating tends to increase the data acquisition times. Typically, data collection is blocked during a significant portion of the respiratory cycle, possibly as high as a third or a half. Blocking the data for significant fractions of the respiratory cycle increases the length of time required to acquire a full set of data significantly.
The respiratory ordered techniques ROPE, COPE, POPE, and the like, were developed for collecting only a single view after collecting information from the respiratory waveform. These techniques did not take into consideration segmentation of k-space.
The present invention provides a new and improved method for compensating for anatomical motion and reducing scan time.
In accordance with one aspect of the present invention, a method of magnetic resonance imaging is provided. Cyclic anatomical movement of a portion of a patient in an examination region is monitored. The anatomical movement cycle is analyzed such that the anatomical cycle is divided into a plurality of preselected portions in accordance with a currently monitored characteristic of the monitored motion. Magnetic resonance is excited in the examination region and a characteristic of the anatomical motion is monitored. A current anatomical cycle portion is determined from the monitored characteristic. A train of magnetic resonance echoes are induced. Each echo is phase-encoded in accordance with the determined anatomical cycle portion. Each echo is read out in the presence of a read gradient to generate a data line. The data lines are phase-encoded to fall into each of a plurality of segments of k-space which correspond to the determined current anatomical cycle. The preceding steps are cyclically repeated and the resultant data lines are reconstructed into an image representation.
In accordance with another aspect of the present invention, a magnetic resonance imaging system is provided. A magnet generates a temporally constant magnetic field through an examination region. A transmitter induces dipoles in the examination region to resonance such that radio frequency resonance signals are generated. Gradient amplifiers and gradient magnetic field coils generate at least slice select, phase, and read magnetic field gradient pulses along orthogonal axes across the examination region. A receiver receives and demodulates the radio frequency magnetic resonance signals read during the read gradients to produce a series of data lines. A reconstruction processor reconstructs the data lines into an image representation. An anatomical monitor monitors a cyclic cycle of the subject in the examination region and produces an output signal indicative thereof. A respiratory cycle measurement circuit connected to the anatomical monitor measures a characteristic of the anatomical monitor signal substantially concurrently with inducing the dipoles in the examination region to resonance. An anatomical signal analyzing circuit determines from the measured characteristic of the anatomical motion signal whether the anatomical motion is in a first portion of the cycle or in a second portion of the cycle. A phase-encoding control phase-encodes the magnetic resonance signals to be one of a positive portion of k-space or a negative portion of k-space in accordance with the determination whether the subject is in the first portion or the second portion of the cycle. In this manner, data lines on one side of k-space are collected during the first portion and data lines on the other side of k-space are collected during the second portion of the anatomical cycle.
One advantage of the present invention is that it compensates for respiratory and other anatomical motion.
Another advantage of the present invention is that it is amenable for use with multiple echo imaging techniques.
Yet another advantage of the present invention resides in the rapid acquisition of image data.
Still further advantages of the present invention will become apparent to those of ordinary skill in the art upon reading and understanding the following detailed description of the preferred embodiments.
The invention may take form in various components and arrangements of components, and in various steps and arrangements of steps. The drawings are only for purposes of illustrating a preferred embodiment and are not to be construed as limiting the invention.
FIG. 1 is a diagrammatic illustration of a magnetic resonance imaging system in accordance with the present invention;
FIG. 2 is a diagrammatic illustration of a multi-slice imaging sequence in accordance with the present invention.
With reference to FIG. 1, a main magnetic field control 10 controls superconducting or resistive magnets 12 such that a substantially uniform, temporally constant magnetic field is created along a z-axis through an examination region 14. A magnetic resonance echo means applies a series of radio frequency (RF) and magnetic field gradient pulses to invert or excite magnetic spins, induce magnetic resonance, refocus magnetic resonance, manipulate magnetic resonance, spatially and otherwise encode the magnetic resonance, to saturate spins, and the like to generate magnetic resonance imaging and spectroscopy sequences. More specifically, gradient pulse amplifiers 20 apply current pulses to selected ones or pairs of whole body gradient coils 22 to create magnetic field gradients along x, y, and z-axes of the examination region 14. A digital radio frequency transmitter 24 transmits radio frequency pulses to a whole body RF coil 26 to transmit RF pulses into the examination region. Each typical radio frequency pulse is composed of a packet of immediately contiguous pulse segments of short duration which taken together with each other and any applied gradients achieve a selected magnetic resonance manipulation. The RF pulses are used to saturate, excite resonance, invert magnetization, refocus resonance, or manipulate resonance in selected portions of the examination region. For whole body applications, the resonance signals are commonly picked up by the whole body RF coil 26.
For generating images of limited regions of the subject, local coils are commonly placed contiguous to the selected location. The resultant radio frequency magnetic resonance signals are picked up by the radio frequency coil 26 or other localized coils and demodulated by a receiver 28.
A sequence control 30 applies a multiple echo imaging sequence, such as a fast spin echo sequence, in which each resonance excitation or shot is followed by a plurality or train of echoes. The echoes within each train are phase-encoded such that the data line derived from each echo of the echo train falls into one of a corresponding plurality of k-space segments as described in greater detail below.
With reference to FIG. 2, in a fast spin echo embodiment in which the echo train has four echoes, k-space is divided into four positive k-space segments above the zero or central phase-encoded data line and four negative k-space segments below the zero or central phase-encoded data line. A radio frequency excitation pulse 401, is applied in the presence of a slice select gradient 421 to induce magnetic resonance. A first radio frequency refocusing pulse 441 is applied to induce a first echo of the echo train 461 which is read out in the presence of a first read gradient 481. A second radio frequency refocusing pulse 501 reinverts the magnetization to induce a second spin echo 521 which is read out in the presence of a second read gradient 541. Analogously, in the four echo embodiment, two additional refocusing pulses 561, 581 induce two additional spin echoes 601, 621. In other embodiments, larger or smaller numbers of echoes can be generated including as few as two spin echoes or as many as 64 or more echoes.
In a next repetition of the sequence, another RF pulse 402 is applied in the presence of a second slice select gradient 422 to excite resonance in another slice of the imaged volume, in the preferred multi-slice embodiment. A first refocusing pulse 442 is applied to induce a first spin echo 462 which is read out in the presence of a read gradient 482. In a four slice embodiment, two additional repetitions are applied. In an eight slice embodiment, eight repetitions are applied before returning to the first slice and repeating the sequence. Analogously, various other numbers of slices can be imaged.
A respiratory monitor 70 monitors a patient's respiratory cycle. A low pass filter 72 or the like smooths the output signal of the respiratory monitor. An adaptive DC compensation stage 74 is used to stabilize the signal. A respiratory motion analyzer 76 analyzes the respiratory motion to develop a probability curve which is stored in a probability table 78. The analyzer 76 continues to analyze the patient's respiratory motion preceding and during a scan and continuously updates the probability table 78. The probability table can be depicted graphically as a graph of probability versus chest displacement. Conceptually, the analyzer and probability table provide a determination based on chest position whether the patient is in the more stationary half or the more moving half of the respiratory cycle. This mid-point between the high and low motion halves is dynamically adjusted during the examination for any changes in the patient's breathing cycle. Similarly, data collection during very high movement periods can be prevented and the remainder of the cycle split in half. The amount of movement which falls in the very high category is selectively adjustable. The analyzer and probability table determine, based on the degree of chest expansion, whether the patient is currently in the more moving or more stationary half of the respiratory cycle. Although the data is divided in halves in the preferred embodiment, the data may be divided in other groupings, such as quarters or the like.
Each time a repetition is to begin, e.g., one of the excitations 401, 402, etc. are applied, a displacement measurement circuit 80 is triggered by the scan controller 30. Based on the measured chest displacement and the probability table, an analysis circuit 82 determines whether it is more probable that the patient is currently in the more stationary half of the respiratory cycle or the half with the greater physical movement. If the patient is in the more stationary half of the respiratory cycle, a circuit 84 selects one of positive and negative phase-encoding, e.g., positive. If the chest displacement shows that the patient is in a portion of the respiratory cycle with more movement, a circuit 86 selects the other of the positive and negative phase-encoding. After the first repeat, the displacement measurement circuit is again actuated to measure chest displacement before the second slice data acquisition and the process is repeated. It should be noted that the displacement measurement is done independently for each slice.
A phase-encoding circuit 88 of the scan controller 30 accesses an appropriate one of a positive phase-encoding step memory 90 and a negative phase-encoding step memory 92. Each of the memories 90, 92 contain a series of phase-encode steps. More specifically, for each of the four echoes of the four echoes per train embodiment, there are a corresponding four phase-encoding steps, one in each segment of k-space. Because each segment of k-space might have, for example, 16 lines, there are a corresponding plurality of sets of phase-encodings. The sequence controller 30 causes a first of the phase-encodings read from the memory to be applied as a phase-encode gradient 941 before the first echo. In the illustrated embodiment, a rewind gradient 961, is applied after the echo to remove the phase-encoding. Before the second echo 521, a second phase-encode gradient pulse 981 is applied to phase-encode the second echo with the phase-encoding selected for the second segment of k-space. Additional phase-encode gradients are applied before the third and fourth echoes 601, 621 to select the appropriate phase-encoding for a data line in the third and fourth segments of positive or negative k-space.
This process is repeated until all of the data lines in all of the segments of all of the slices are collected. Preferably, the memories 90 and 92 also keep a record of which phase-encodings have been applied within each of the slices. Although one would statistically expect half of the readings to occur in the most stationary portion of the respiratory cycle and half in the more rapidly moving half of the respiratory cycle, there are sometimes statistical aberrations. That is, there are situations where all of the data lines in one of the positive and negative half of k-space have been collected, but there are still several data lines in the other half to collect. When this occurs, data may be discarded until measurement in the proper half of the respiratory cycle can be collected. Alternately, in order to limit the duration of the scan, the phase-encode circuit 88 takes data from the other half of the respiratory cycle in order to complete the missing data lines promptly. When this is done, the phase-encodes used are selected so as to cause the smallest variation from the desired pattern.
It is to be appreciated that an analogous process is used when the respiratory cycle is divided into four or some other number of portions. As another alternative, a respiratory motion sensor 94 is triggered at the beginning of each repetition to sense the acceleration or rate of change of physical displacement. The rate of change circuit provides an indication regarding how close the patient is to crossing between the two halves of the respiratory cycle and whether the patient is moving toward the other half. If a significant number of echoes will occur after the patient has crossed into the other half of the respiratory cycle, the analysis circuit 82 classifies the data in the half of the respiratory cycle in which the majority of echoes occur. As yet another alternative, the analysis circuit 82 classifies a fraction of the echoes in one half of the respiratory cycle and the rest of the echoes in the other half of the respiratory cycle.
The phase-encode selection circuit 88 further controls a sorting circuit 96 which sorts the data lines into appropriate positions within a data line memory 98. An image reconstruction processor 100 reconstructs the data set into an image representation that is stored in an image memory 102. A video processor 104 converts selected slices, three-dimensional renderings, and other portions of the data in the image memory into appropriate format for display on a human-readable monitor 106.
The combination of k-space segmentation with the selection of phase-encode steps based on position in the respiratory cycle allows for a significant reduction in scan time over respiratory gating and other respiratory ordered techniques such as ROPE, COPE, and POPE. Independently selecting phase-encode steps on a slice by slice basis minimizes the necessity of rejecting data and assists in reducing scan time.
The invention has been described with reference to the preferred embodiment. Obviously, modifications and alterations will occur to others upon reading and understanding the preceding detailed description. It is intended that the invention be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
|Cited Patent
|Filing date
|Publication date
|Oct 26, 1984
|Jan 21, 1986
|Ottieri Enterprises
|Ski boot
|Aug 16, 1985
|Nov 10, 1987
|General Electric Company
|Method for reducing image artifacts due to periodic signal variations in NMR imaging
|Nov 15, 1985
|Feb 9, 1988
|Picker International, Inc.
|Centrally ordered phase encoding
|Apr 17, 1986
|Mar 1, 1988
|Siemens Aktiengesellschaft
|Method for providing a magnetic resonance image from respiration-gated image data
|May 22, 1986
|Oct 25, 1988
|Siemens Aktiengesellschaft
|Nuclear magnetic resonance tomography apparatus and method
|Nov 21, 1989
|Feb 12, 1991
|Picker International, Inc.
|Adaptive filtering of physiological signals in physiologically gated magnetic resonance imaging
|Feb 1, 1990
|Jul 30, 1991
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|Motion artifact minimization
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|Reduced scan time cardiac gated magnetic resonance cine and flow imaging
|Aug 4, 1993
|Jan 3, 1995
|General Electric Company
|MRI cardiac image produced by temporal data sharing
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|Dec 19, 1995
|Johns Hopkins University
|Method for reducing image artifacts in magnetic resonance images acquired with synchronization to physiological cycles
|Feb 1, 1994
|Mar 19, 1996
|Board Of Trustees Of The Leland Stanford Junior University
|Slice profile stabilization for segmented k-space magnetic resonance imaging
|Nov 13, 1992
|Jun 4, 1996
|U.S. Philips Corporation
|Magnetic resonance imaging method
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|Dec 3, 1996
|Siemens Aktiengesellschaft
|Method for phase correction of nuclear magnetic resonance signals
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|Apr 1, 1997
|Shimadzu Corporation
|MR imaging method and apparatus utilizing gradient and spin echo technique
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|Motion Artifact Reduction With Three Point Ghost Phase Cancellation , Xiang, et al., JMRI 1(6):633 642 (1991).
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|RARE Imaging: A Fast Imaging Method for Clinical MR , Hennig, et al. MRM 3:823 833 (1986).
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|Two Point Interference Method For Suppression of Ghost Artifacts Due to Motion , Xiang, et al., JMRI 3(6):900 906 (1993).
|Citing Patent
|Filing date
|Publication date
|Oct 15, 1998
|Nov 7, 2000
|General Electric Company
|Respiratory gating method for MR imaging
|Apr 16, 2002
|Sep 6, 2005
|Ge Medical Systems Global Technology Company, Llc
|Systems and methods for manipulating changes in phase encodes
|Sep 16, 2002
|Jul 14, 2009
|The United States Of America As Represented By The Department Of Health And Human Services
|MRI navigator methods and systems
|Sep 1, 2005
|May 17, 2011
|The Board Of Trustees Of The University Of Illinois
|Adaptive acquisition and reconstruction of dynamic MR images
|Apr 23, 2012
|Nov 24, 2015
|The Regents Of The University Of California
|Mapping vascular perfusion territories using magnetic resonance imaging
|Apr 16, 2002
|Oct 17, 2002
|Ge Yokogawa Medical Systems, Limited
|Data collection method and MRI system
|Nov 5, 2002
|May 6, 2004
|Scimed Life Systems, Inc.
|Medical device having flexible distal tip
|Sep 1, 2005
|Oct 5, 2006
|Nitin Aggarwal
|Adaptive acquisition and reconstruction of dynamic MR images
|Apr 23, 2012
|Oct 25, 2012
|The Regents Of The University Of California
|Mapping vascular perfusion territories using magnetic resonance imaging
|May 17, 2007
|Dec 1, 2010
|Method and device for implement CT respiration gate control
|Sep 25, 2014
|Mar 31, 2016
|Siemens Aktiengesellschaft
|Verfahren zu einer Bewegungskorrektur f�r eine Magnetresonanz-Fingerprintinguntersuchung an einem Untersuchungsobjekt
|U.S. Classification
|600/410, 600/534, 324/307, 324/309
|International Classification
|Cooperative Classification
|European Classification
|Aug 28, 1996
Owner name: PICKER INTERNATIONAL, INC., OHIO
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HALAMEK, JAMES A.;LONCAR, MARK J.;GULLAPALLI, RAO P.;REEL/FRAME:008176/0962
Effective date: 19960819
|Sep 28, 2001
|Fee payment
Year of fee payment: 4
|Nov 21, 2005
|Fee payment
Year of fee payment: 8
|Jan 18, 2010
|Maintenance fee reminder mailed
|Jun 16, 2010
|Lapse for failure to pay maintenance fees
|Aug 3, 2010
|Expired due to failure to pay maintenance fee
Effective date: 20100616


text:
All Items > Knives > Folding Knives > Kizer (Folding)
- Overall Length:8.50"
- Blade Length:3.50"
- Blade Material:CPM-S35VN
- Blade Style:Wharncliffe
- Blade Grind:Hollow
- Finish:Gray
- Edge Type:Plain
- Handle Length:5.00"
- Handle Material:Titanium
- Color:Gray
- Weight:7.05 oz.
- User:Right Hand
- Pocket Clip:Tip-Up
- Knife Type:Manual
- Opener:Thumb Stud
- Lock Type:Frame Lock
- Brand:Kizer
- Model:GPB1
- Model Number:Ki44743
- Designer:John Gray
- Country of Origin:China
- Best Use:Everyday Carry
- Product Type:Knife
This Kizer GPB1 offers a rugged John Gray design that is perfectly suited for outdoorsmen and lifelong knife enthusiasts. GPB1 stands for Gray's Pocket Brute #1, and this powerful knife is true to it's name. The large wharncliffe style blade has a plain edge with a grind positioned below the handle grips. Perfect for a wide range of cutting tasks you will love the feel of the GPB1. The curved handle is made from titanium and comes equipped with a titanium pocket clip, lanyard hole and a custom pivot. With an elegant look and a rugged EDC design, that GPB1 is destined to be your constant companion.
Customer ReviewsWrite a review for this item
Knife Collector Buys Another!
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I am a knife collector (ZT's, Spydercos, Emersons, Medford, etc..) and this is my favorite knife. I ended up purchasing two Kizer Kane knives and now am purchasing my second John Gray GPB1. I can''t believe these have not sold out yet, such an unbelievable deal and killer unique folder, that has everyone falling in love with it once seen / held / or flipped. Get one while available, u will be way stoked!!!!
Affordable Thuck
Jonathan L.
It's a John Gray THUCK at one fifth the price. I have a "real" THUCK and this version is scary close to that. If you can get the scratch together I'd say go for it. It's a EDC THUCK! Been in my pocket since it arrived, love it! Now I don't have to beat up my original so much, ha ha ha!
Overbuilt mastery
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This thing is built like a tank but still smooth as silk deployment. No faults at all. Great knife!


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