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Patriotic Decor
August 30, 2014 by Core'dinator
Filed under Core Blog
Celebrate this Labor Day with American pride! Create this beautiful USA bunting and patriotic decor just in time for the holiday!
- Tim Holtz Kraft Core Shattered Cardstock
- Tim Holtz Kraft Core Nostaglia
- Glitter Silk Cardstock
- Jenni Bowlin Core Impressions
- May Arts Silver Trim
- Raffia
- David Tutera Casual Elegance Silver Buckets
- Misc. Star Sequins
- Misc. Frame
The most difficult part of this project is making the rosettes. Start by searching rosette tutorials on Pinterest, you will find a ton! Make a few of these out of core'dinating cardstock. Adhere to banners, adding trim and other embellishments. Don't forget to cut out the USA title from some Glitter Silk Cardstock.
Next up, make the stars by doing some simple scoring. Scor from the back, fold and sand. The are super simple to make and we will need a few. Some for the frame itself and some for the buckets.
Add bits and pieces of different embellishments and you have a great piece of home decor.
Shaunte Wadley
Happy Veterans Day
November 11, 2011 by Ellen
Filed under Core Blog, Design Teams
Today we want to honor all of those men and women that serve our country and their families.
Thank you. Thank you! For keeping us safe, for your dedication, for your sacrifice.
Design Team Member Andrea Amu created this gorgeous Liberty block for us today. We should all have one of these to remind us every day of the sacrifices those brave men and women make for us!
Don't forget about Monday!
We will see you then!!!
Happy Memorial Day
May 30, 2011 by Core'dinator
Filed under Core Blog, Cosmo Cricket
Today we wanted to take time and remember all the amazing men & women that have and continue to
fight for our country and our freedom every day. THANK YOU!
Design Team Member April Derrick created this layout in remembrance especially for this post today. First off, isn't this photo a treasure? And check out the amazing details like the mixture of Core Impressions and how April turned the cardstock over and doodled on the backside!
And Design Team Member Brianne Nevill made this super cute project that is perfect for all your Memorial Day festivities!
LOVE all that vintage goodness!!!


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Cudgel Troll
Magic 2010 — Uncommon
Creature — Troll
Cudgel Troll is legal in the following formats:
French Commander
Modern Duel Commander
Recently viewed cards:
Magic 2010 — Uncommon
Creature — Troll
Cudgel Troll is legal in the following formats:
French Commander
Modern Duel Commander
TCGPlayer avg. price:
Creature — Elk (4/3)
When Somberwald Stag enters the battlefield, you may have it fight target creature you don't control.
Creature — Elf Shaman (2/2)
When Yeva's Forcemage enters the battlefield, target creature gets +2/+2 until end of turn.
Creature — Rhino (2/3)
When Thriving Rhino enters the battlefield, you get (two energy counters).
Whenever Thriving Rhino attacks, you may pay . If you do, put a +1/+1 counter on it.
Creature — Elf Druid (2/1)
: Add one mana of any color to your mana pool.
Creature — Wolf Warrior (2/2)
Whenever a Wolf or Werewolf you control becomes the target of an instant or sorcery spell, put a 2/2 green Wolf creature token onto the battlefield.
Creature — Spirit (2/2)
Orchard Spirit can't be blocked except by creatures with flying or reach.
Legendary Creature — Spider (3/5)
Delirium — When Ishkanah, Grafwidow enters the battlefield, if there are four or more card types among cards in your graveyard, put three 1/2 green Spider creature tokens with reach onto the battlefield.
: Target opponent loses 1 life for each Spider you control.
Legendary Creature — Elf Warrior (3/4)
Other Elf creatures you control get +1/+1.
Whenever Dwynen, Gilt-Leaf Daen attacks, you gain 1 life for each attacking Elf you control.
Creature — Cat (4/4)
When Riparian Tiger enters the battlefield, you get (two energy counters).
Whenever Riparian Tiger attacks, you may pay . If you do, it gets +2/+2 until end of turn.
Creature — Elf Shaman (2/2)
When Llanowar Empath enters the battlefield, scry 2, then reveal the top card of your library. If it's a creature card, put it into your hand. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom of your library and the rest on top in any order.)
Creature — Human Horror (1/1)
When Foul Emissary enters the battlefield, look at the top four cards of your library. You may reveal a creature card from among them and put it into your hand. Put the rest on the bottom of your library in any order.
When you sacrifice Foul Emissary while casting a spell with emerge, put a 3/2 colorless Eldrazi Horror creature token onto the battlefield.
Creature — Elf Warrior Ally (5/4)
Vigilance, trample
Creature — Human Scout (3/3)
When Intrepid Provisioner enters the battlefield, another target Human you control gets +2/+2 until end of turn.
Creature — Giant (6/6)
Renown 6 (When this creature deals combat damage to a player, if it isn't renowned, put six +1/+1 counters on it and it becomes renowned.)
Outland Colossus can't be blocked by more than one creature.
Creature — Elf Artificer (1/1)
Fabricate 2 (When this creature enters the battlefield, put two +1/+1 counters on it or create two 1/1 colorless Servo artifact creature tokens.)
Whenever Cultivator of Blades attacks, you may have other attacking creatures get +X/+X until end of turn, where X is Cultivator of Blades's power.
Creature — Human Werewolf (2/3)
Whenever an opponent casts a spell during your turn, draw a card.
At the beginning of each upkeep, if no spells were cast last turn, transform Hermit of the Natterknolls.
Creature — Elf Artificer (3/3)
When Armorcraft Judge enters the battlefield, draw a card for each creature you control with a +1/+1 counter on it.
Creature — Unicorn (2/2)
All creatures able to block Prized Unicorn do so.
Creature — Human Scout (3/2)
When Byway Courier dies, investigate. (Put a colorless Clue artifact token onto the battlefield with ", Sacrifice this artifact: Draw a card.")
Creature — Wurm (4/3)
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subset: commoncrawl


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Rallón, Norma I. PhD*; Pineda, Juan A. MD, PhD†; Soriano, Vincent MD, PhD*; Neukam, Karin PhD†; Vispo, Eugenia MD*; Rivero, Antonio MD, PhD‡; Labarga, Pablo MD, PhD*; Caruz, Antonio PhD§; Restrepo, Clara MSc*; Camacho, Angela MD, PhD‡; Barreiro, Pablo MD, PhD*; Benito, Jose M. MD, PhD*
*Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
†Infectious Diseases Unit, Hospital de Valme, Seville, Spain
‡Infectious Disease Unit, Hospital Reina Sofía, Córdoba, Spain
§Immunogenetics Unit, Faculty of Sciences, Jaen University, Jaen, Spain.
Correspondence to: Dr José M. Benito, MD, PhD, Infectious Diseases Department, Hospital Carlos III, Calle Sinesio Delgado 10, Madrid 28029, Spain (e-mail: email@example.com).
Supported in part by grants from Fundación Investigacion y Educacion en SIDA (F-IES), Red de Investigacion en SIDA (ISCIII-RETIC RD06/0006), FIS projects PI10/01664 and PI10/01232, Consejería de Salud de Andalucía (projects PI-0247-2010, PI-0208/2009 and 0036/2010), Agencia Lain Entralgo and the European Union 6th Framework Programme (NEAT, No. LSHP-CT-2006-037570). J.A.P. and A.R. are the recipients of extension grants from the Fundación Progreso y Salud of the Consejería de Salud de la Junta de Andalucía (Reference AI-0021 and AI-0011/2010, respectively). K.N. is the recipient of a "Sara Borrell" postdoctoral perfection grant from the Instituto de Salud Carlos III (SCO/523/2008).
The authors have no conflicts of interest to disclose.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jaids.com).
Received November 23, 2011
Accepted February 8, 2012
Background: Both viral and host factors influence response to peginterferon-α plus ribavirin (pegIFNα/RBV) in patients with chronic hepatitis C. The impact of these variables is more pronounced in HIV/Hepatitis C virus (HCV)–coinfected individuals, in whom treatment response rates are lower.
Methods: Virological responses at multiple time points were assessed in all HIV/HCV-coinfected patients that completed a first course of pegIFNα/RBV. Viral responses were stratified by HCV geno/subtypes and IL28B rs12979860 variants.
Results: A total of 331 HIV/HCV-coinfected patients were analyzed. HCV geno/subtype distribution was as follows: HCV-1a in 97, HCV-1b in 62, HCV-3 in 122, and HCV-4 in 50. Age, gender, CD4 counts, plasma HIV RNA and liver fibrosis stage did not differ significantly across HCV geno/subtypes. In contrast, mean serum HCV RNA was greater in HCV-1a compared with the rest (P < 0.0001). The proportion of IL28B CC variants was higher in HCV-3 compared with the rest (P = 0.001). Virological responses were better in HCV-1b than HCV-1a at any given time point during therapy. IL28B variants significantly influenced virological responses across all HCV-1 subtypes, with the strongest effect seen in HCV-1a. In a multivariate linear regression analysis, both HCV-1b and IL28B CC variants were significantly associated with greater HCV RNA drops at weeks 4 (R = 0.52, p < 0.0001) and 12 (R = 0.49, P < 0.0001) of therapy.
Conclusions: The response to pegIFNα/RBV therapy is lower in HCV-1a than HCV-1b in HIV/HCV-coinfected patients. The strongest influence of IL28B variants is seen in HCV-1a. This information may be relevant when using most directly acting antivirals in coinfected patients along with pegIFNα/RBV, given that selection of drug resistance occurs more frequently in HCV-1a than HCV-1b.
Hepatitis C virus (HCV) infects more than 175 million people worldwide.1 In western countries, HCV is the leading cause of end-stage liver disease and hepatocellular carcinoma and the main indication for liver transplantation.1 HCV and HIV-1 share routes of transmission and establish chronic infections; therefore, coinfection is relatively common (15%–40%).2 Until recently, therapy for chronic hepatitis C was based on a combination of peginterferon-α (pegIFNα) and ribavirin (RBV) given for 6–18 months, depending on early viral kinetics and HCV genotype.3 Unfortunately, these medications are poorly tolerated and overall less than a half of patients achieve sustained HCV clearance.3 This figure is lower in HIV/HCV-coinfected patients.2 Thus, identification of baseline predictors of treatment success is desirable for making adequate treatment decisions, encouraging therapy in those with a high likelihood of cure, and conversely deferring treatment when the chances of response are minimal and/or expected drug-related side effects may be troublesome.
Until recently, the best baseline predictors of sustained virological response (SVR) were HCV genotypes 2 or 3, low serum HCV RNA, null or minimal liver fibrosis, and younger age.4 More recently, different genome-wide association studies identified single nucleotide polymorphisms (SNPs) upstream of the IL28B gene coding for interferon (IFN)-λ3 as strongly associated with the chance of SVR in HCV-monoinfected individuals.5–7 Similar findings have been reproduced in HIV/HCV-coinfected patients.8 The SNP with the strongest association, rs12979860, confers more han 2-fold increase in SVR rates after adjusting for other baseline variables. The effect of this SNP can be recognized early on therapy strongly influencing early viral kinetics in both HCV-monoinfected and HIV/HCV-coinfected patients.9–11 Patients carrying CC alleles show faster reductions in serum HCV RNA during the first weeks of therapy, regardless of other baseline variables.11
The recent introduction of directly acting antivirals (DAA) is rapidly changing the management of chronic hepatitis C patients.12,13 HCV protease inhibitors telaprevir and boceprevir were the first DAA approved for the treatment of patients infected with HCV genotype 1. Their use in combination with pegIFNα/RBV increases the frequency of SVR by at least 25%.14,15 Given the high genetic diversity and rapid mutation rate of HCV, emergence of viral variants resistant to DAA has been observed in patients who did not achieve complete viral suppression very rapidly on therapy.16 Because adding pegIFNα/RBV to DAA greatly diminishes the risk of selecting drug-resistant variants, combination therapy will remain necessary in the near future.17 In this scenario, IL28B variants will continue to remain important as long as pegIFNα/RBV is kept as part of the hepatitis treatment regimen. Although IL28B allelic variants may not influence directly the efficacy of DAA, their effect modulating viral kinetics in response to pegIFNα/RBV may remain important on triple therapy.
This is an observational retrospective study of 2 Spanish cohorts of HIV/HCV-coinfected patients recruited in Madrid11 and Andalucia,18 which were recently merged into a single database. All subjects completed a full course of pegIFNα/RBV therapy and had validated outcomes. All underwent liver fibrosis staging at baseline using elastography, and all had been tested for the IL28B rs12979860 genotype. Other relevant demographic, clinical, and laboratory parameters were recorded from medical records. The main exclusion criteria were baseline CD4 counts lower than 300 cells per microliter, positive serum HBsAg, current alcohol abuse (>60 grams per day), prior exposure to IFNα-based therapy, and prior episodes of hepatic decompensation.
Treatment regimens included pegIFNα-2a or pegIFNα-2b at standard doses (180 μg/week or 1.5 μg/kg/week, respectively) plus weight-adjusted RBV (1000 mg/day for patients weighting <75 kg and 1200 mg/day for patients weighting >75 kg). Following international guidelines for coinfected individuals,2 patients with HCV genotypes 1 or 4 received either 48 or 72 weeks of treatment, and patients with HCV genotype 3 received 24 or 48 weeks of therapy, according to virological response at week 4. Early stopping rules were applied for subjects with suboptimal virological responses at weeks 12 or 24.2
The following on-treatment virological responses were assessed as follows: rapid virological response (RVR, HCV RNA <10 IU/mL at week 4), early virological response (EVR, >2 log IU/mL reduction in HCV RNA levels at week 12), complete early virological response (cEVR, HCV RNA <10 IU/mL at week 12), and end of treatment virological response (EOTVR, HCV RNA <10 IU/mL at the end of therapy). SVR was defined as undetectable serum HCV RNA 24 weeks after completion of therapy; otherwise patients were considered as relapsers.19 Moreover, HCV RNA declines at weeks 4 and 12 after initiating treatment were recorded for each patient. For the purpose of this study, relapsers were considered along with nonresponders, who were patients who experienced suboptimal virological responses during the treatment period, and accordingly did not complete the planned duration of therapy. Patients with poor drug compliance and/or who discontinued therapy due to side effects were excluded from this analysis.
To participate in the study, written informed consent for genetic testing was obtained from all individuals, and the study protocol was evaluated and approved by the hospital ethics committee. Both plasma and peripheral blood mononuclear cells were stored for all patients.
Plasma HCV RNA was measured using a real-time polymerase chain reaction assay (COBAS TaqMan, Roche, Barcelona, Spain), which has a lower limit of detection of 10 IU/mL. HCV genotyping and subtyping was performed using a commercial reverse transcriptase-polymerase chain reaction hybridization assay (Versant HCV Genotype v2.0 LiPA, Siemens, Barcelona, Spain), which maximally reduces the chances of HCV genotype misclassification.20 Plasma HIV RNA was measured using Versant HIV-1 RNA v3.0 (Siemens, Barcelona, Spain), which has a lower limit of detection of 50 copies per milliliter.
The extent of liver fibrosis was measured using transient elastography by FibroScan (Echosens, Paris, France). Details about this noninvasive method, the examination procedure, and correlation of liver fibrosis estimates with liver biopsy have been reported elsewhere.21 The median value of all tests per patient is expressed in Kilopascal (kPa) units. Advanced liver fibrosis (severe fibrosis or cirrhosis, corresponding to METAVIR scores F3 and F4, respectively) was defined for liver stiffness values ≥9.5 kPa, based on results from studies conducted in both HCV-monoinfected and HIV/HCV-coinfected patients.22
The characterization of IL28 allelic variants was performed at Hospital Carlos III and Universidad de Jaen. It was conducted in a blinded fashion on DNA specimens collected from each individual. The SNP rs12979860 was assessed with a custom TaqMan assay designed by Ge et al5 using the 5' nuclease assay with allele specific TaqMan probes (ABI TaqMan allelic discrimination kit and the ABI7900HT Sequence Detection System, Applied Biosystems, Carlsbad, CA). Genotyping calls were manually inspected and verified before release.
The main characteristics of the study population, and the different parameters evaluated are expressed as median and interquartile ranges. Comparisons between groups were carried out using nonparametric Analysis of Variance. Associations between different qualitative parameters were explored using χ2 or Fisher exact tests, as appropiate. Univariable (χ2 test) and multivariable (logistic regression) analyses were used to assess the predictors of treatment outcome. Linear regression analysis was employed to assess the parameters associated with the decrease of HCV RNA level at weeks 4 and 12. All statistical analyses were performed using the SPSS software version 13 (SPSS Inc, Chicago, IL). All P values were 2-tailed and were considered as significant only when below 0.05.
Table 1 summarizes the main characteristics of the HIV/HCV-coinfected study population. The whole population comprised 331 patients, 178 recruited at Hospital Carlos III in Madrid, and 153 at 2 different hospitals in the south of Spain. HCV geno/subtypes distribution was as follows: 97 (29%) HCV-1a, 62 (19%) HCV-1b, 122 (37%) HCV-3, and 50 (15%) HCV-4. Of note, all patients were of European ancestry, being absent Asians or Africans.
Some baseline characteristics differed in subjects infected with distinct HCV geno/subtypes. Serum HCV RNA was higher in HCV-1 compared with HCV-3 or HCV-4 patients. Among HCV-1 patients, slightly greater levels were seen in HCV-1a than HCV-1b patients. Accordingly, the proportion of HCV-1a patients with low serum HCV RNA was significantly lower compared with the rest. The frequency of IL28B CC alleles was significantly higher in HCV-3 patients than in the rest, being similar when comparing HCV-1a and HCV-1b patients. Last, aspartate aminotransferases tended to be higher in HCV-3 patients, with no significant differences comparing HCV-1a and HCV-1b patients.
The proportion of patients achieving virological response at different time points is recorded in Table 2. As expected, it was lower in patients infected with HCV-1 or HCV-4 than in those infected with HCV-3. Interestingly, there were marked differences when comparing HCV-1a and HCV-1b patients, with significantly higher rates of treatment response at all time-points on therapy in HCV-1b patients (except for RVR that showed only a trend). Overall, rates of treatment responses in HCV-1b patients were intermediate between those seen in HCV-1a (the lowest) and those achieved by HCV-3 patients (the highest).
The effect of IL28B variants on treatment responses was assessed in patients infected with different HCV-1 subtypes. As expected, CC carriers showed a higher rate of RVR, EVR, cEVR, EOTR, and SVR than CT/TT patients, and this was true for both HCV-1a and HCV-1b (Fig. 1A). However, the beneficial effect of the IL28B CC variant was more pronounced in HCV-1a than HCV-1b patients at any given time point.
Using another approach, we compared treatment responses according to HCV-1 subtypes in IL28B CC and non-CC carriers. In non-CC carriers, treatment responses were higher in HCV-1b than HCV-1a patients; whereas in CC carriers, there were generally no significant differences according to HCV-1 subtype (Fig. 1B). Altogether, these data supports an independent effect of both HCV-1 subtypes and IL28B variants on treatment response. Accordingly, when patients were split out into 4 categories defined by HCV-1 subtype and IL28B variant, the lowest treatment response rates were seen in HCV-1a/IL28B non-CC patients, whereas the highest responses were seen in HCV-1b/IL28B CC patients (see Figure, Supplemental Digital Content 1, http://links.lww.com/QAI/A299).
The results of univariate analyses were confirmed using a multivariate logistic regression model, in which the independent influence of HCV-1 subtypes and IL28B variants on treatment responses was adjusted to baseline serum HCV RNA, liver fibrosis staging, gender, and age. As shown in Table 3, HCV-1b and lL28B CC remained as independent predictors of EVR, cEVR, and EOTVR. The same analysis applied separately to HCV-1a and HCV-1b patients confirmed the independent influence of IL28B variants on treatment outcomes in both groups of patients, with a more pronounced effect on HCV-1a than HCV-1b patients (Table 3).
The significant and independent association of IL28B variants and HCV-1 subtypes with treatment responses prompted us to explore the mechanism behind it. For this purpose, the variation in plasma HCV RNA levels at weeks 4 and 12 of therapy with respect to baseline was calculated for the subset of patients for whom these data were available (266 patients had HCV RNA values at week 4 and 313 patients at week 12). Then, the median variation in viremia at these 2 time points was compared in different groups of patients. First, we compared viral kinetics in patients according to HCV geno/subtype and found that patients infected with HCV-1b experienced significantly faster kinetics than those infected with HCV-1a (Fig. 2A). It must be highlighted that the fastest decay, however, was seen in HCV-3 patients. Overall, viral kinetics in HCV-1b patients were intermediate between those seen in HCV-3 and HCV-1a/HCV-4 patients.
Patients harboring the IL28B CC variant showed significantly faster viral decays than non-CC carriers regardless HCV-1 subtype (Fig. 2B), although the influence was more pronounced in HCV-1a patients. There was a difference of nearly 3 log IU/mL in the level of decrease of HCV RNA at week 12 when comparing CC and non-CC carriers infected with HCV-1a, whereas it was only of 1 log in HCV-1b patients (Fig. 2B). A multivariate linear regression analysis confirmed that both IL28B variants and HCV-1 subtypes independently predicted viral kinetics at weeks 4 and 12 of pegIFNα/RBV therapy. Moreover, IL28B variants remained as the only significant predictor of viral kinetics when considering separately HCV-1a and HCV-1b (see Table, Supplemental Digital Content 2, http://links.lww.com/QAI/A300).
The recognition of the strong impact of IL28B variants on response to pegIFNα/RBV has been a major breakthrough in hepatitis C therapeutics. Besides its influence on SVR in both HCV-monoinfected5–7 and HIV/HCV-coinfected8,18,23–25 patients, recent data in both groups of patients have shown that early HCV kinetics is also significantly modulated by IL28B polymorphisms,9–11,26,27 especially in patients infected with the most difficult-to-treat HCV genotypes 1 and 4. Our study is the first to extend these findings to HIV/HCV-coinfected patients carrying different HCV-1 subtypes. We noticed that on treatment responses and SVR rates were uniformly worse in HCV-1a as compared with HCV-1b patients, and statistically significant at all time points with the exception of RVR, most likely due to the small number of HCV-1 patients that attained undetectable HCV RNA at week 4. This striking observation has only occasionally been reported in HCV-monoinfected individuals28 and without deserving much attention.
Our study has shown that the effect of IL28B variants on HCV RNA kinetics during pegIFNα/RBV therapy in seen in both HCV-1 subtypes, although the beneficial effect is more noticeable in HCV-1a than HCV-1b patients. A multivariate analysis confirmed that both HCV subtype and IL28B variant were independent predictors of on-treatment responses. More importantly, this was independent of other well-known predictors of viral response, including baseline serum HCV RNA.
Another important finding of our study was that early viral kinetics in HCV-1 patients was significantly influenced by both IL28B alleles and HCV subtype. In fact, these 2 variables were the only ones significantly determining changes in serum HCV RNA during the first 12 weeks of therapy. As with treatment response rates at different time points, the effect of IL28B variants on early serum HCV RNA kinetics was more pronounced in HCV-1a than HCV-1b patients. Altogether, the fastest viral kinetics was seen in IL28B CC carriers infected with HCV-1b, whereas the slowest viral declines were seen in IL28B non-CC carriers infected with HCV-1a. Thus, the innate immunity mechanisms involved in treatment-induced viral clearance might be more efficiently operating in HCV-1b than HCV-1a.
The results obtained in our study may have important clinical implications in the new DAA era. Given that most DAA already approved or in advanced stage of clinical development are being used as part of triple combinations along with pegIFNα/RBV, an important question to address is the role of IL28B variants in this setting. Although a direct effect of IL28B alleles on DAA should be negligible if any at all, the global efficacy of triple combinations may still be dependent on the modulating effect of IL28B variants on the pegIFNα/RBV backbone. The strong influence of IL28B variants on early viral kinetics we recognized, with a differential impact on distinct HCV-1 subtypes, highlights that patients infected with distinct HCV-1 subtypes and harboring different IL28B variants may achieve different SVR rates using triple combinations.
There are scenarios in which our findings may be particularly relevant. First, boceprevir, one of the recently approved HCV protease inhibitors, is given as part of a triple combination including a lead-in phase of 4 weeks with only pegIFNα/RBV.17 In this way, the final efficacy of triple therapy is the best in the subset of patients that achieved maximal early viral load declines with pegIFNα/RBV alone. Selection of drug resistance to subsequently added boceprevir often compromises the achievement of SVR in initially poorly responders. Our findings suggest that this adversity should be particularly feared at baseline in the subset of patients harboring IL28B CT/TT and infected with HCV-1a. This population might require closer monitoring or deserve other treatment options.
Secondly, since most DAA exhibit a high antiviral effect but suffer from a low barrier to resistance, one of the most crucial effects of pegIFNα/RBV as part of triple combination therapy is to prevent selection and outgrowth of pre-existing DAA-resistant mutant viruses. In this way, the global efficacy of any triple combination regimen could vary according to pegIFNα/RBV-driven viral kinetics. Interestingly, an intriguing lower efficacy of triple therapy has been reported for HCV-1a compared with HCV-1b in several trials.15,29 Our results support that an intrinsic lower efficacy of pegIFNα/RBV on HCV-1a versus HCV-1b could contribute to this observation. Clearly, further studies analyzing the combined effect of HCV subtypes and IL28B variants on the efficacy of triple combination therapies are warranted.
Last, the results of our study highlight the continuous importance of IL28B testing in the new DAA era, at least whereas pegIFNα/RBV remains part of combination therapy. This test is cheap and has to be made only once in life. Therapeutic decision-making may be supported by baseline IL28B testing and be particularly helpful in patients infected with HCV-1a, in whom treatment failure and emergence of drug-resistant viruses may be more common.16 This subset of patients may require closer monitoring of early viral kinetics and/or plan in advance proper rescue interventions.
In summary, this is the first study demonstrating an important role of both IL28B variant and HCV-1 subtype in predicting on-treatment virological responses to pegIFNα/RBV therapy in HIV/HCV-coinfected individuals. This effect is largely mediated by an enhancement of viral kinetics during the first 12 weeks of therapy. Interestingly the protective effect of the IL28B CC variant is mainly seen in HCV-1a patients in whom responses are the poorest. Thus, baseline IL28B testing may helpfully assist treatment decisions in the new era of triple combination therapy including DAA.
HCV subtypes; HIV/HCV coinfection; IFN-lambda; IL28B; viral kinetics
© 2012 Lippincott Williams & Wilkins, Inc.
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Satellite TV
Satellite TV
Satellite TV really has come on in leaps and bounds over the last 50 years or so hasn't it. Cast your mind back, if possible, to the fuzzy black and white pictures which we were so happy to watch in the 1960's, and then compare it to the wonderful HDTV pictures we get nowadays. Satellite TV really has moved with the times and made the best possible use of new technology.
Latest Improvements to Satellite TV
When I say "latest", I don't necessarily mean this week, this year, or even this decade, it's just a figure of speech to look at how satellite TV really has improved over the years.
- Satellite TV Accessibility – it used to be very difficult for people in remote areas to have any TV at all – the cables weren't long enough, but as long as you have a good clear view of the southern sky, just about anyone can benefit from Satellite TV these days.
- Satellite TV Program Choices – there really is an endless number of program options available on satellite TV these days. People who have moved across the world from their homelands can still have the option of watching TV from home, making them feel much less isolated and more in touch with home.
- Satellite TV Digital Technology – the latest advances in digital technology has meant a vast improvement in both capacity and quality. The visual and audio quality has improved, and it all takes much less bandwidth than analog.
- Satellite TV and Internet Integration – what's the difference between a TV screen and a Computer monitor? Not much is the answer to that one these days. Everything can now be completely integrated, so you can watch TV on the computer, surf the internet on your TV – what is the world coming to?
So you see, Satellite TV really has made some gigantic steps for mankind since the 1960's.
How to Buy Satellite TV
If you don't already have satellite TV (and there are thousands of people who don't) then don't let all of this talk about technology put you off. You still only have to switch on the TV and press a few buttons, it's a very simple process from the consumer point of view. All you need to do is to shop around a little, there are plenty of TV stores and companies all waiting for your business. Do shop around though, although there are only two major satellite TV suppliers in the United States, Dish Network and DirecTV, you will be surprised at the different deals on offer. They will seem very similar on the surface (they have to be competitive) but very often different things may be revealed in the small print.
Satellite TV Channel Packages
This is another big decision which you will need to make, along with the rest of your family – although on second thoughts, you might be better off not concerning them in the decision making process, it's bound to cause arguments. Disney, Discovery, Cartoons, Sports, Films – you know how everybody likes something different. Take a look at the different channel packages available, the prices you'll pay and make a sensible decision on which channels you are realistically likely to watch.


text:
Alfred New Orleans Drumming Series (DVD)
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Economics Departments, Institutes and Research Centers in the World
İşletme ve Ekonomi Fakültesi
Girne Amerikan ÜniversitesiTranslation: Faculty of Business and Economics
Translation: Girne American University
Location: Kyrenia, Northern Cyprus
Homepage: http://business.gau.edu.tr/
Phone: +90 392 650 20 00
Fax: +90 392 650 20 61
Postal: Universite Caddesi, P.K. 5, Karmi Kampüsü, Karaoğlanoğlu, Girne / KKTC
Handle: RePEc:edi:iigauty
Additional details:
People who have registered with RePEc and have claimed to be affiliated with this institution:Find all publications of all authors listed below conveniently compiled on IDEAS. Authors with publications are listed below with . We have lost contact with authors marked with ?, and they do not count towards the ranking of this institution.
This listing is provided to you by EDIRC at the Economic Research Department, Federal Reserve Bank of St. Louis.
Please send additions and corrections to Christian Zimmermann.


text:
Monday, March 9, 2009
The end of the beginning
After their win against Purdue, it seemed like Northwestern's fan base doubled in size as an at large birth seemed like a possibility. Now, the Wildcats likely have to win the conference tournament in order to go dancing. But that shouldn't diminish the work the Wildcats have done this season. The 17 wins by Bill Carmody's team represents the most, well, ever (at least as far as I can tell). Not bad for a squad coming off an 8-22 campaign. So a hearty congrats to Northwestern for that. But they're not done yet, and hopefully this loss isn't too deflating for the Wildcats.
Ohio State finishes this season just as it finished last - at 10-8 in conference play. That's probably good enough for an at large bid, but it was probably good enough last year. The good news is that the Buckeyes won't be playing the Spartans in the first round of the Big Ten Tournament this year, and instead will take on Wisconsin.
Iowa and Penn State needed 50 minutes of basketball to sort out their differences before the Hawkeyes prevailed 75-67 in the 67 possession contest. Todd Lickliter has gone all Thad Matta and installed sophomore wing Jake Kelly as the team's point guard out of necessity. Despite that, Iowa's turnovers have gone into hiding over the past 3 games. The Hawkeyes only had 11 in this one, which was a big reason for the victory. Sure, Penn State's defense can hardly be categorized as "tenacious," but this is nonetheless a good sign for Lickliter's squad. Iowa has struggled with turnovers despite running the ex-Butler coach's system, maybe this is a sign that those days are over. Kelly led the Hawkeyes with 22 points on 16 shots and dished 11 assists. Talor Battle poured in 26 points on 20 shots, and also pulled down 10 rebounds before fouling out in the second extra period. Box score.
The loss by Penn State killed their chances at a #2 or #3 seed in the Big Ten Tournament. Maybe that's for the best, given their efficiency margin. It just doesn't seem right to hand out such a high seed to a team that's actually been outscored by its opponents in conference play. But the Nittany Lions still have 10 wins in conference play and enough quality victories that should get them to the Dance no matter what happens in the conference tournament. But I'm not on the Selection Committee - start the letter-writing campaign, Penn State fans - so I'm sure there will be some sweating in State College over the next week.
Michigan State finished off the season with an ugly win over Purdue, 62-51 in a 68 possession game. The Spartans were sloppy, turning it over 19 times, but they made up for it by grabbing 46% of their misses. And neither team could throw it in the ocean. But Michigan State, as is their style, pounded the ball inside and received 15 more free throws than the Boilers. That was largely the difference in this one. JaJuan Johnson had 12 points on 9 shots for Purdue, and Kalin Lucas had 21 points on 14 shots (six turnovers though). Box score.
So despite not playing a game over the weekend, Illinois had a pretty good couple of days. With Penn State and Purdue losing, the Illini move into the #2 seed on the conference tournament, while Purdue takes the #3 spot.
Michigan put itself back on the bubble (in a good way) by beating Minnesota at the Barn on Saturday, 67-64 in a 57 possession game. In a way, the Wolverines were playing a game of H-O-R-S-E, in that as soon as a shot went up for either team, Michigan figured the possession was over. John Beilein's team grabbed just thirteen rebounds against the much taller Gophers, but still found a way to win. Sure, both teams shot very well (especially from the FT line, as they combined to go 32-34 from the stripe), but that's still a really low total. But Minnesota's second opportunities were equalized by their sloppiness with the ball, as they coughed it up 18 times. Lawrence Westbrook led Minnesota with 16 points on 6 shots, while DeShawn Sims put up 24 on 15 shots. Box score.
Both of these teams sit at 9-9, and each has a very good non-conference win as well. Minnesota's RPI is 41, Michigan's is 42. You gotta figure that if one of them is in, then the other is as well. Of course, the corollary is that if one is out, then the other is also likely headed to the NIT (how Joe Lunardi figures all of this out is beyond me). Bottom line - a win or two in the conference tournament could go a long way, for both teams.
Wisconsin finished off their season with a trouncing of Indiana, 85-61 in a 61 possession game. It was a typical ball control offense for the Badgers, as they turned it over just 5 times. Compare that to Indiana, who coughed it up on 26% of their possessions. In addition to valuing the basketball, Wisconsin also shot lights out (59.0 eFG), grabbed 42% of their misses, and attempted 32 free throws. It was the best offensive performance of the season for the Badgers. Joe Krabbenhoft led Wisconsin with 19 points on 10 shots, and also grabbed 9 rebounds. Verdell Jones spearheaded the Hoosier attack with 23 points on 10 shots. Box score.
Despite the win, Wisconsin's status as an at large team is up in the air. The 10-8 conference record is good enough, but the best win on the resume is a home victory against Illinois. Their best road win is at Penn State. If I was on the committee, they'd be in (start the letter writing campaign, Badger fans!), but I'm sure Bo Ryan will feel a lot better with a win in the conference tournament.
Ok, for those keeping score, here are your tournament seeds:
#1: Michigan State
#2: Illinois
#3: Purdue
#4: Wisconsin
#5: Ohio State
#6: Penn State
#7: Michigan
#8: Minnesota
#9: Northwestern
#10: Iowa
#11: Indiana
Of course, the efficiency margins tell us there isn't much difference between #5 and #9. Before the season started, everyone knew that Purdue and Michigan State were the teams to beat. Well, true to form, those teams did finish atop the conference standings and efficiency margin.
But, I think everyone expected Purdue to finish at least a bit closer to the Spartans, who ended up winning the whole thing by four games. That isn't dominance in the Memphis/Conference USA kind of way, but it was nonetheless dominance for the amount of parity we saw this year. Congrats to Tom Izzo's team for a fine season.
10 comments:
That MSU ran away with the conference title (relatively) is not good news for B10 teams that want to go dancing. I think we get five or six teams in (sorry Michigan, Minnesota, and maybe Wisconsin).
- March 9, 2009 at 6:25 AM
If the Big Ten only manages five or six teams, why would Wisconsin be worried? They have the 4th best resume in the league. What five or six teams get in ahead of them?
- March 9, 2009 at 10:12 AM
Keep in mind Wisconsin was 5-0 against the 5, 6 and 7 seeds. So it's doubtful all or any of them leapfrog the Badgers in the committee's eyes. How are the Badgers in any trouble? Especially considering everyone is saying the Big Ten is about a 7 bid conference at this point.
Obviously I'm a Badger fan, but I get a little upset when poeple post stuff on the 'net without knowing what they are talking about.
- March 9, 2009 at 10:21 AM
I assume Wisconsin is in if we get six teams. But if only five?
Well for starters:
2. Illinois
3. Purdue
Leaving two spots for OSU, PSU, and Wisconsin. What big wins does Wisconsin have? Home against Illinois? PSU beat Purdue and Illinois at home, and MSU and Illinois away. OSU beat Purdue at home and Notre Dame on a neutral court. Sure its a close call but Wisconsin draws the short straw. All three teams will have the chance to make their case this weekend. Given that Wisconsin and OSU are facing off on Friday, the loser of that affair may knock themselves out of the NCAA.
- March 9, 2009 at 10:46 AM
- Poop Bandit said...
I don't see why everyone is assuming Penn State is in. I agree that 8 teams will be hard to get in and I really think PSU might be the ones left out. Not only am I pretty sure that they are the worst of the 8, but their rating on Pomeroy and RPI confirm my thoughts. I would be happy with 7 teams in the dance. As an Ohio State fan, I'm kind of hoping Penn State loses to Indiana, which would make me less nervous about the Buckeyes getting in. Their non conference schedule was a joke and they happened to catch MSU and Purdue on off nights. They also have a ton of close wins and are high up in the "luck" factor on Pomeroy. Great job (as usual) of pointing out that Penn State was outscored in conference play. That statistic is extremely telling.
- March 9, 2009 at 10:53 AM
Wisconsin is 3-0 against PSU and OSU comibined. That's the best possible reason to give them the nod right there. On top of that computer rankings favor Wisconsin, especially over PSU, more even with OSU. At the very worst Wisconsin is the 5th team out of the Big Ten. Not that it matters because the Big Ten is getting between 6 and 8 teams in. Find me one bracket out right now that has only 5 Big Ten teams getting in. Just one bracket, that's all I ask. That's where I think the original poster is totally misguided.
- March 9, 2009 at 11:39 AM
Both OSU and UW are in no matter what happens Friday. They are not going to drop 3 seed lines by losing a game against the other team. Not going to happen. Get your facts straight and stop showing a bias. Do some research.
- March 9, 2009 at 11:41 AM
Wow, talk about selling your own conference short. Who is crazy enough to believe the Big Ten is getting fewer than 6 bids?
I mean, if you don't take at least 6 Big Ten teams, who would you take? One of the ACC/Big East teams with a losing conference record? A 4th SEC team? A 4th Mountain west team? Utah State? Creighton? Davidson? I mean seriously, the Big Ten has far and away the best bubble teams by a very large margin.
- March 9, 2009 at 1:53 PM
- Binge Thinking said...
Northwestern tied its record for regular-season wins with 17. According to Wikipedia, that's the most since '82-'83.
- March 9, 2009 at 9:41 PM
- Josh said...
I saw the same Wiki entry, but that record reflects overturned results due to NCAA sanctions. Additionally, statsheet.com shows only 16 wins for that season. I'm not sure what the violations were, and whether it resulted in forfeitures or simply vacated the wins for the other teams, but I think as far as on-court results go, this Wildcat team has the most wins. Of course, the discussion gets more interesting if it turns out that Craig Moore received money as a recruit and less interesting if Northwestern wins another game or two.
- March 10, 2009 at 6:36 AM


text:
Check in from 12h / Check out prior to 12h
Ibis Budapest City: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Budapest, Hungary.
Strategically located in the centre of the city, this 3-star hotel makes for an ideal base in Budapest. It also provides free Wi-Fi, a 24-hour reception and a hair salon.
Hotel description
This modern hotel offers luggage storage, bicycle rental and a concierge. Corporate amenities include a business centre.
Every modern room at Ibis Budapest City offers a private bathroom and all the essentials for a comfortable stay. They provide movies-on-demand, wireless internet access and a flat-screen TV.
A satisfying breakfast is available for purchase, and there are numerous cafés and eateries close by. Those looking for after-dinner entertainment can enjoy the in-house casino.
Located in Budapest City Centre, Ibis Budapest City is surrounded by well-known nightlife spots. Guests can also easily visit Oktogon, the Dohany Street Synagogue and the Hungarian National Museum.
Hotel features
Pet Friendly, Air Conditioned, Cable / Satellite TV, In Room Movies, Hair Dryer, TV, Shower, En suite, Private Bathroom
Business Center, Concierge, Elevator / Lift, 24 Hour Reception, Dry Cleaning, Multilingual Staff, Wake-up Service, Laundry service, Bicycle Rental, Photocopier, Luggage Storage, Self Laundry
Bath / Hot Tub, Casino
Internet Connection (wireless)
Nightclubs, Salon, Private Toilet, Shoe Shine
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Miley Cyrus Blasts YouTube Stars Justin Bieber And Rebecca Black
Miley Cyrus has made her feelings known about internet sensations Justin Bieber and Rebecca Black. She said: "It should be harder to be an artist. You shouldn't just be able to put a song on YouTube and go out on tour," she told Australia's Daily Telegraph.
Meanwhile, Rebecca Black's video has received over 50 Million hits on YouTube since it debuted. Black told Teen Vogue: "People tell me I sound like Taylor Swift. Once you hear my sound without any adjustments—just my raw voice—it's unique." She also said that Justin Bieber would be her Friday night dream date!
Bieber dissed Rebecca Black after her video became viral, musing on Twitter "Saturday comes after Sunday? Weird."
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Nice and comfortable house south Haarlem
Size105 m²
Floor No.2
- Air conditioning
- Internet/WiFi
- Balcony/terrace
- Family/child friendly
- Kitchen
- Parking available
- Pets allowed
Accommodation summary
|alphons ariensstraat, 2037vj Haarlem, Netherlands
|Property type
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
|2 days ago
The house has 3 floors:
First floor:
Entrance, toilet, living room sofa, tv, dvd, free WiFi-internet access and dinette. Big open kitchen with fridge, freezer, stove, oven, microwave, Senseo coffee machine, water cooker and dishwasher. Entrance to the garden with seating places and you can use the barbeque if you want to.
Second floor:
Master bedroom with double Auping bed and second tv, second bedroom with double bed, (luggage) room with single bed and big closet where you can store and iron your clothes, bathroom with bath, separate shower, second toilet and sink.
Third floor:
Study room with single bed, wash machine and dryer, entrance to balcony.
We can arrange towels and bed sheets for you if wanted.
If you want other services please let us know
House rules
No Smoking inside the house.
Please close doors and windows properly when leaving the house.
No loud music after 23:00 hours
|Weekly rate for up to 2 guests
|Monthly rate for up to 2 guests
|Price for > 2 guests
|$ 16 US per guest/night extra
|Check-in after
|On arrangement
|Check-in before
|On arrangement
|Check-out before
|On arrangement
|Cancellation Policy
Reviews of this property
The house is clean and well decorated. However the available parking is road parking, it is not off road parking. It is clear that this house is lived in by somebody when not let out to visitors, there are many items around the house that are personal items and calendars with personal notes and dates on it. The bedroom draws have personal items in them, so no room for your stuff. Only one bedroom has wardrobe in it and one bedroom has garden chairs as bedside cabenets. There is no real oven, only a microwave combi oven almost in possible to cook for 6 people. One of the gas rings did not work, but Hans has promised to mend this. The gas ring ignition did not work and you need to use a lighter to light the gas. The kitchen is not well kitted out, no measuring jugs and other items missing that make cooking very difficult. Excellent Wi-Fi access around the house.
The house is spacious and well equiped for a comfortable stay. It's well connected to all the turistic places in Holland if you have a car which you can park free at the front of the house.
I'd only suggest some minor things like bed lamps/stands by the beds and some newer sheets but in any case, I would really recommend this house if you want to visit Ámsterdam and its surroundings.
Ideal accommodation if you want to stay outside Amsterdam. House clean and comfortable with plenty of equipment/ facilities. Ideal if you have a pet dog. Excellent public transport both to and from the airport, into and out of Amsterdam and elsewhere. Close to the shops and a number of take-aways. Hans was very polite, helpful and friendly.
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We had a great time in Hans House in Haarlem!
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We will come back next year :-)
We had a fantastic weekend. Hans was very helpful with transport and information. The property was well equipped and very clean. In fact Hans went that 'extra mile' and was very obliging when I asked him to get us some shopping. I would recommend his property and hospitality.
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The apartment is very modern and comfortable. It was helpful to have a bathroom and a toilet, but as we told the owner we miss a mirror in the bathroom.
El apartamento es muy moderno y confortable. Nos fue útil tener un baño y un aseo, aunque como le comentamos al propietario echamos de menos un espejo en el aseo.
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Ever want your own, private Google to use in your business enterprise so that you can find all of your information quickly, easy, and more importantly, when you need it?
That's the idea behind VirtualWorks, a Boca Raton, Florida-based company founded in 2009 when it moved from Norway and received the tutelage of Ed Iacobucci (co-founder of Citrix Systems).
The Universal Index is the core technology behind VirtualWorks and is, simply, a full index of all files and their contents on an enterprise's network. A way to tackle "data sprawl," the idea is to pull every bit of content into one database that is fully indexed and easily queried. Like I said: Google for the private network.
In today's world where corporate data is spread across several systems and networks and even geographically spread to boot, finding ways to better manage all of that data so it's still accessible and useful to the business is not easy. Sure, CRM or ERP might be controlled and accessible, but are they unified or cross referenced at all? What about other data like email and documents?
There are a lot of ways to collaborate, share, and utilize data amongst multiple users, but very few ways to make the data fully accessible – no matter whether all people involved know it exists or not. A lone document on a corporate server can be the key to unlock a deal or change how management is looking at things, but if no one knows it's there..
This, I think, is where it's going to be for databases in the near future. As data sprawl grows, so will the need for solutions like VirtualWorks. Expect this type of technology to become more and more prevalent.


text:
55 House Salad
Total Time
Prep 15 mins
Cook 0 mins
There was a chain of Italian restaurants in the Columbus, Ohio area that had this awesome salad as their house salad. I don't like blue cheese, so asked for it to be omitted, but loved the combination of bacon, lettuce and dressing. When the salad was brought to the table, they then offered fresh ground black pepper. I think this recipe was posted in the Columbus Dispatch Newspaper. NOTE: Due to this being a restaurant recipe, it makes a alot of dressing, about two cups, so you might want to cut the amount of dressing to 1/4 or 1/2 of this recipe.
Ingredients Nutrition
- 1 cup vegetable oil
- 1⁄2 cup white vinegar
- 1⁄2 cup sugar
- 2 -4 teaspoons garlic powder (to taste)
- 1 head lettuce, chopped
- 5 slices bacon, cooked and crumbled
- 4 ounces blue cheese, crumbled
- 1 small red onion, thinly sliced
- Combine first four ingredients for the dressing in a container and shake well.
- Put the lettuce in a bowl, sprinkle with bacon, blue cheese (if using) and red onion rings.
- Drizzle enough of the dressing to coat or to taste along with freshly ground pepper (optional) and enjoy.
Most Helpful
Outstanding! This is now my favorite salad recipe!! The only changes I made to the recipe: exchange the blue cheese for feta, add chunked cucumbers and half the dressing (still have some left over..yum!). This salad got rave reviews from my dinner guests. It's simple and absolutely delicious!!
A simple and delicious salad. The salad was reduced to 1 serving provided a generous amount of dressing. The sugar in the dressing was reduced by half and was perfect for my taste. Mixed spring mix was used for the greens and the cheese was crumbled Queso Fresca making this delicious salad gluten free. Made for Culinary Quest 2014.
this was nice salad cut down for one used bacos loved the blue cheese made for italian leg of the quest cakepops on parade


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Distances given are in a straight line from the centre of Edgbaston but travel routes may be longer.
0.9 Miles
32 St James Road, Edgbaston, Birmingham B15 2NX
Edgbaston Beaumont offers luxury apartments suitable for care needs and independent living, with 24-hour access to skilled nursing care. Trained and qualified staff follow the direction of personally tailored care plans, with excellent standards of… more
Group / Provider:
Barchester Healthcare Ltd
Care provided for Alzheimer's
0.5 Miles
Speedwell Road, Edgbaston, Birmingham B5 7PR
Gracewell of Edgbaston opened on 7 April 2015 and provides dedicated residential, nursing and dementia care of the highest standard for their residents. The home offers luxury interior designed accommodation, with all bedrooms en-suite and much larger… more
Group / Provider:
Gracewell Healthcare Ltd
Care provided for Alzheimer's
0.8 Miles
5 Church Road, Edgbaston, Birmingham B15 3SH
Sunrise of Edgbaston is set in the heart of Birmingham's prestigious Edgbaston district - famous for its test cricket ground - the community is one of premier providers of high-quality residential, nursing and dementia care to Birmingham and the wider… more
Group / Provider:
Sunrise Senior Living
Care provided for Alzheimer's
1.1 Miles
64 Cregoe Street, Lee Bank, Edgbaston, Birmingham B15 2DY
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Care provided for Alzheimer's
43 Uplands Road, Selly Park, Birmingham B29 7JS
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8/14 Greenland Road, Selly Park, Birmingham B29 7PP
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Skipton Road, Ladywood, Birmingham B16 8JJ
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94 Selly Park Road, Selly Park, Birmingham B29 7LL
1.2 Miles
River Brook Drive, Birmingham B30 2SH
1.6 Miles
133 Anderton Park Road, Moseley, Birmingham B13 9DQ
1.5 Miles
49/51 Park Road, Moseley, Birmingham B13 8AH
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199/203 Alcester Road, Moseley, Birmingham B13 8PX
1.2 Miles


text:
Web posted Thursday, June 11, 1998 2:13 p.m. CT
Dry conditions cause danger
Randall and Potter counties are preparing for the worst, just in case.
The dry weather forced both counties to institute bans in the past two days on outdoor burning and fireworks.
"It's just parched," Canyon Deputy Fire Chief Joe Rice told Randall County Commissioners Court Tuesday.
That succinctly sums up the weather conditions for the Texas Panhandle.
In response, Randall County Judge Ted Wood wisely has issued a "declaration of disaster."
Outdoor burning is prohibited and so is the use of fireworks. The judge has the full support of the rest of Commissioners Court. They authorized him to keep the burn ban in place as long as necessary. The fireworks issue was not on Tuesday's agenda so court approval to extend that prohibition technically will have to wait until the next meeting. Commissioners let it be known, however, that they fully support the fireworks ban.
Potter County unanimously followed suit Wednesday with a ban on outdoor burning and aerial fireworks.
The outdoor burning ban extends for seven days and exempts barbecue grills and burning of household trash. The ban may be extended if needed, Potter County Judge Arthur Ware said.
Area wheat crops are nearly ready for harvest, said Osage Fire Department Chief Scott Johnson. One spark could mean financial ruin for a Panhandle wheat farmer, he said.
Gov. George W. Bush has gone so far as to declare 80 percent of the state in a drought and in severe danger of fire. That proclamation includes all of the Panhan-dle. It's only June and the state is seeing August-like conditions of heat and dryness, he said.
One of the most outstanding attributes of Panhandle people is the way they pull together in a crisis. No doubt scores of local people would help battle runaway brush fires to keep their neighbors' crops and homes from being destroyed. The best way to show forth that commendable attitude, however, is to make such heroic actions unnecessary in the first place.
Wild west invades Amarillo
If you're a real cowboy or just a fan of the old west, Amarillo is the place to be this weekend.
The 11th Annual Cowboy Roundup USA kicks off a three-day run Friday with a western trade show and sale beginning at 10 a.m. at the Commercial Exhibits Building at the Tri-State Fairgrounds and with a ranch rodeo performance at 7 p.m. at the Outdoor Arena.
This year's event will also feature plenty of good eatin' with the World Cham-pion Chuckwagon Competition, scheduled from 7:30 a.m. to noon Saturday at the chuckwagon campsite west of the Commercial Exhibits Building. The public is invited to eat following the conclusion of the competition.
The Chuckwagon Roundup will include approximately 33 wagons from as far as California in a competition that judges food preparation, flavor, appearance and wagon and camp authenticity.
Other events include ranch horse races, the Buck Ramsey Memorial Gathering, the Red Steagall Rodeo Dance and ranch horse cutting competition.
Proceeds benefit The Outfit, a group dedicated to preserving the area's western heritage.
The Amarillo area's vast western heritage will be displayed in various ways during Cowboy Roundup USA.
It is a great opportunity to see many of the area's cowboys and ranchers doing what they do best.
We'd love to hear your feedback. © 1998 Amarillo Globe-NewsWebmaster
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Windward Oahu residents can expect more air traffic noise for the next few weeks. 12 F/A 18 fighter jets just arrived at Marine Corps. Base Hawaii. And as KITV 4's Cam Tran reports, not only are they here for training but to deter any threats from North Korea.
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Report: No Evidence Of Drugs Found In Justin Bieber's Home
Police who raided Justin Bieber's Calabasas, Calif., home last week have claimed that there was no evidence of any drugs in his home during their investigation over his recent egg throwing incident and the arrest of his pal Lil Za, who was booked for drug possession.
TMZ.com reported that Bieber's camp has been urging him to go to rehab over his use of sizzurp, the concoction made from mixing codeine-based cough syrup with soda that's been known to trigger seizures, and that his home had several empty bottles of the stuff along with several styrofoam cups (the preferred way to drink it) laying around during the raid.
There were also two cookie jars filled with marijuana and a special room in the house -- the Bob Marley Room -- where everyone goes to smoke bongs and hookahs.
But according to E! News, the Los Angeles Sheriff said there wasn't any evidence of any drug use or illegal substances or a smoke room.
Police obtained a search warrant to look for evidence in the case brought against Bieber by one of his neighbors over an egging incident last week that caused a reported $20,000 in damage; more specifically, they were seeking any video surveillance records and also confiscated Bieber's cell phone, the contents of which he worries will be leaked to the public.
Police did find a substance they believe is MDMA, aka Ecstasy or Molly, belonging to Lil Za, who has a room at Justin's mansion. They arrested him on the spot.
TMZ maintained its story, posting an image of the Marley Room and reporting that a police spokesperson said that police weren't searching for any drugs, just video sources that could implicate Justin in the case. So whether or not things were in plain sight of officers, none of them noticed anything.


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Aboveground transit ending at 1WMATA is announcing that they will be suspending aboveground Metrorail service and all Metrobus and MetroAccess service starting at 1 pm. Metrorail trains will run on the "snow map" routes, while some non-passenger trains will run along the aboveground routes to try to prevent snow buildup. Meanwhile, I'm off to shovel my front and back steps.
Enough tv, i'm putting on my XC skis, and hitting the road.
Darren hit the nail on the head....with most sidewalks not plowed/shoveled, most folks were walking in the streets/roads. Thankfully, there wasn't a whole lot of traffic out there, so folks could get away with it, as did I on my bike (such as that was...wound up walking half the way anyway due to the snow). Except for one guy at the Beltway/Route 1 interchange, most drivers didn't seem to mind, and those that got stuck were very appreciative of those pedestrians who helped un-stuck them. I wound up helping 5 vehicles in such a way before I got home.
So sounds like ABC7 is barking up the wrong tree.
by Douglas A. Willinger on Dec 19, 2009 8:39 pm • link • report
Even though it's underground, the Metro is creeping along sluggishly. The false starts and lurching were even worse than usual today. Try not to go anywhere, and instead get out and enjoy the snow!
Those who say "people in the DC area don't know how to drive in snow" have a point when we get accumulation in the 0-8" range. However this weekend there is no reason to utter that phrase. Driving in 10-20" inches, when most roads hadn't been plowed, has almost nothing to do with knowledge/driver skill and everything to do with whether or not your vehicle can handle it. Most of us don't have vehicles that can handle this. I'm never going to invest in snow tires, 4WD, etc... as long as I'm living in an area that doesn't experience large snowfalls regularly...
And while snow tires can make a big difference, as does 4WD, the biggest vehicle advantage is ground clearance.
I used to laugh at the people buying the milk and bread at the supermarket. Back when I was single, my two main stops were the liquor store and then to go someplace to rent some videos.
Our development seems to be well plowed right now - they came through with a big bobcat and scooped it up. The VDOT cameras in the area suggest that the main roads are in somewhat reasonable shape - if we had a reason to go out today for anything we could probably get out without a problem.
Tomorrow we will need to get out however. We are flying out in the afternoon through Dulles - hopefully the airports are back up to speed by then..
In fact, I'd say that "picking your battles" is more important than knowing how to drive in snow. If you can't drive in half an inch of snow, don't do it.
Actually, the streets are being used as streets. We're just used to using them as motorways. I've been pleased to see motorists being very cautious and far more courteous than usual.
@Jack Russell: I find the bread/milk rush amusing as well. I'd rather buy something good, like toppings for pizza!
For the most part the pedestrians were not a problem, except for the ones who chose to walk down the middle of the road or step directly in front of vehicles.
Incidentally, DDOT seems to have done a good job clearing the roads today especially in comparison to VDOT (even Wilson Boulevard was still snow-covered this afternoon...)
Add a Comment
- Are public spaces really public when not everybody can use them?
- Cell service in tunnels, junking old rail cars, getting finances in order. Here's what's in Metro's Back2Good plan.
- If racial inequities didn't exist, DC would look like this...
- What happens when people without cars move to places built for driving?
- Metro now has an official plan for getting better in 2017. It's called Back2Good.
- WMATA recommended express bus service along 14th Street NW four years ago. Is it time to make it happen?
- The DC reps on the WMATA board might veto late-night closures


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Karen-547169 is a 38-year-old single mom from Farmington, Mich. She hails from a large, close-knit family – the youngest of seven.
The green-eyed beauty enjoys cooking, dancing and traveling, especially by the ocean.
Once her son began school, Karen felt she had the time to earnestly search for a mate. Joining CatholicMatch was a no-brainer. "I can't imagine not sharing my faith and the Mass with my other half," she said. "It is so great to see that there are still a lot of faithful Catholic singles out there."
She's enjoyed the site even more than she expected. "I think that CatholicMatch is a great resource on many levels for Catholic singles – for dating and more." Her favorite component? Reading "inspiring" success stories. "And it is nice to move from emailing to a chat on a secure site," she added.
Dating as a never-been-married single mom isn't easy, Karen admits. "I want to be sure that the person I open my heart to can also open his heart to my child. My son is such a sweet, loving child. But because he is so precious to me, I am not quick to introduce him. I will know in my heart when that feels right. And when it is, my son will be an added blessing in his life too."
Looking on the lighter side of things helps Karen stay young at heart. She and her son laugh often. Some days they sing and dance in the kitchen.
Having the right perspective helps too. Karen knows she's not the only one reconciling past wounds in the pursuit of a spouse. "I think most of the singles out there have had relationships in their past that did not work out. Hopefully we can take the lessons learned from our past and apply them to our future."
Her deep faith gives her a positive attitude. "I am guessing that whoever He has out there for me is going to be worth the wait! Ultimately, I have to trust that God has a plan and have faith that I am where I am supposed to be for now and that I will be where He intends me to be tomorrow."
In the meantime, Karen will tap into the power of prayer. "I don't think anyone can spend even 15 minutes in adoration without feeling more peace."


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September 11, 2013 —
MILFORD, PA — Milford will celebrate local farms and the bounty of the region with its first Tri-State Farm to Table Festival on Saturday, September 28 from 1 to 5 p.m. in the courtyard of River Rock Inn (210 Second St.). The environmental non-profit Air Soil Water will present this free event featuring farm vendors, food for purchase, live music by They Know, fun for kids and educational lessons by the Pocono Environmental Education Center (PEEC), The Mother's Project and Breathless Beauty on composting, gardening, juicing and more.
Tying into the celebration, every restaurant in town including River Rock, Delmonico Room, Water Wheel and Peter's Europa will feature at least one dinner special that evening using 100% local ingredients sourced from the area. Customers will learn about the origins of the dish and taste the difference that fresh, local food can provide. Some of the restaurants already have extensive local options and others have agreed to join in and create a special menu for the evening working together with local growers like Willow Wisp Organic.
Attendees will have a chance to meet and talk with local farmers who actually grow the food we eat and learn about healthy delicious food options that directly benefit our neighbors, local economy and health.
This event is free to the public and to vendors, funded with proceeds from the Pete Seeger concert. Air Soil Water will partner with Barryville Farmers Market, who will have their Saturday weekly market open prior to joining the Milford event.
To learn more about this event, participating restaurants, growers, education partners and how you can get involved, visit www.airsoilwater.org [1].


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The vivid colours and crystal clear sea might make you think this photograph had been digitally enhanced. You would be wrong.
Chris McLennan, a New Zealand photographer, took the image, which is split under and over water while snorkelling in the Bora Bora Lagoon, French Polynesia.
Mr McLennan said: "I wanted to show the sea life below and Mount Otemanu above the surface. There were tropical fish of all colours, remoras and rays along with a lot of plump reef sharks."
When his guide threw fish heads to bring the sharks in closer, it created a "frenzy of feeding fish


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Fly Friendly map PDF (5.16 MB)
Fly Friendly Procedures
Aircraft Owners and Pilots Association Noise Awareness Steps
Unless otherwise directed by the Tower, please comply with the following:
Return to top
If practical, avoid noise-sensitive areas. Make every effort to fly at or above 2,000 feet over such areas when over flight
cannot be avoided.
Consider using a reduced power setting if flight must be low because of cloud cover or overlying controlled airspace or when
approaching the airport of destination. Propellers generate more noise than engines; flying with the lowest practical RPM setting
will reduce aircraft noise substantially.
Perform stalls, spins, and other practice maneuvers over uninhabited terrain.
Familiarize yourself and comply with local airport noise abatement procedures.
On takeoff, gain altitude as quickly as possible without compromising safety. Begin takeoffs at the start of a runway,
not at an intersection.
Use PAPI. This will indicate a safe glide path and allow a smooth, quiet descent to the runway.
Retract the landing gear either as soon as a landing straight ahead on the runway can no longer be accomplished or as soon
as the aircraft achieves a positive rate of climb. If practical, maintain best-angle-of-climb airspeed until reaching 50 feet
or an altitude that provides clearance from terrain or obstacles. Then accelerate to best-rate-of-climb airspeed. If
consistent with safety, make the first power reduction at 500 feet.
Fly a tight landing pattern to keep noise as close to the airport as possible. Practice descent to the runway at low power
settings and with as few power changes as possible.
If possible, do not adjust the propeller control for flat pitch on the downwind leg; instead, wait until short final. This practice
not only provides a quieter approach, but also reduces stress on the engine and propeller governor.
Avoid low-level, high-powered approaches, which not only create high noise impacts, but also limit options in the event of engine failure.
Flying between 11 p.m. and 7 a.m. should be avoided whenever possible.
Note: these are general recommendations; some may not be advisable for every aircraft in every situation. No noise reduction
procedure should be allowed to compromise flight safety.


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Craftsman Coffee Table (Antique Walnut) for $77.90. Select in-store pickup at Walmart to save on shipping. Otherwise, shipping is $9.97 for a total of $87.87 shipped. Here is a screenshot for your reference. The coffee table has tapered legs, a bottom shelf, and measures 34"W x 19"D x 18"H. Most places have it for about $99.
Great Deals and Coupons 1


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Rated 3.8 out of 5 by 6 reviewers.
Rated 5 out of 5 by A1traveler Best camera vest I almost didn't purchase this vest due to a very poor review, the one about the faulty zippers, etc. I was somewhat reluctant but ordered it anyway, and am I glad I did, I can't find anything wrong with the zippers, and the quality of the workmanship throughout is well above par. A must for travel, especially for photography! May 31, 2015
Rated 5 out of 5 by cameraking WHAT A WONDERFUL PURCHASE!!! Received my safari vest,opened the package and was so pleased with the color ,fit, quality and the overall bush poplin cotton that was used. The attention to all details in the manufacturing of this vest was very impressive. I went outside for a wildlife photo shoot and this vest is wonderful The pockets hold enough that I do not have to carry any additional cases for my photo equipment. I am looking forward to traveling with my new vest to Mexico. I am glad to have found a company like yours that sells quality merchandise with a guarantee. My vest was shipped out the next business day and was received in three days. Looking forward to receiving your catalogue. June 3, 2016
Rated 4 out of 5 by Dogwater Very Good Vest (but a little heavy) Pros: Great design. Excellent quality. Excellent fit and finish. 15 pockets! (6 inside). Reinforced fabric and stitching at shoulders and stress points. Cons: Heavy. 5 of 7 zippers are metal. This adds to weight. The 2 inside zippered pockets are good quality plastic. Double or triple layered fabric in places also adds some weight. Because it's 100% cotton it gets wrinkly. April 13, 2016
Rated 4 out of 5 by TravelerNick Great for travel This vest has numerous pockets that will come in quite handy when traveling. Quality is quite good. The vest is on the heavy side and (size M) is a bit long for a 5'9" person. June 28, 2016
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Rated 1 out of 5 by Lastword Not as good as expected When I unwrapped this vest I couldn't get the zipper to work. I was afraid of tearing it. I finally got it open. All of the zippers on the pockets were difficult as well. I put it on and didn't like how the zipper only came to my chest. I think this would have been better with buttons and Velcro on the pockets where the zippers are. Maybe the zippers in time would move more easily but they should work smoothly right from the start. I'm sending this back. September 11, 2014
1-6 of 6
Product:74177-Men\'s Bush Poplin Safari Vest


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Soft, durable 100% cotton jersey-knit construction
Rib-knit collar with three-button henley closure
Side-seamed construction minimizes twisting
Chevron-shaped patch pocket at the left chest
The Carhartt Workwear Short-Sleeve Henley is an all-purpose work shirt that's perfect by itself in warm weather or for layering when it gets cold. Made of 6.75-oz., 100% cotton jersey-knit fabric, the shirt features a rib-knit collar with three-button henley closure and a chevron-shaped patch pocket at the left chest. Side-seamed construction helps minimize twisting and maximize comfort. Heather Gray fabric: 90% cotton, 10% polyester blend. Ash fabric: 99% cotton, 1% polyester blend. Imported. Style #: K84.


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I fond the ingegrating factor to be 1+x and now I dont know where do to from there
It doesn't help to find the integrating factor if you don't know what an "integrating factor" is! Don't memorize formulas, learn concepts!
An integrating factor for a linear differential equation of the form dy/dx+P(x)y= f(x,y) is a function of x, such that multiplying both sides of the equation by it converts the left side into a "perfect" derivative so that the equation becomes: .
If (1+ x) really is an integrating equation (I haven't checked that) then multiplying 1+x on both sides converts the equation to . Now integrate both sides with respect to x.


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In today's pill-popping culture, it's almost an involuntary reflex to reach straight for the meds whenever something ails us in the slightest. But it turns out there are other, unexpected ways to reduce pain, and we're not referring to your grandpa's preferred method of "suck that shit up like we used to back before the world transformed into one giant pussy."
So for some easy pain reduction, remember to ...
5Drink Coffee (Or Another Caffeinated Beverage)
Christopher Robbins/Photodisc/Getty
Let's say you have one of your bi-annual urges to unglue yourself from the couch and get into shape. So you head to the gym and hit that shit hard -- treadmill, exercise bike, weight lifting, the rack ... just, everything. You feel pretty damn good about yourself -- right up until the next day, when holy shit your everything hurts. That's when you reach for the over-the-counter pain relievers or, depending upon your area of residence, maybe a more holistic approach. But it turns out you could have prevented the need for pain relief altogether by simply hyping yourself up on caffeine beforehand.
In one study, two groups of healthy volunteers signed up to perform some "damaging eccentric exercise" and have their level of pain intensity measured by researchers, who were presumably wearing scary clown masks. One group was given caffeine capsules equivalent to drinking two-and-a-half cups of coffee, while the other group was given placebo pills. At the end of the series of exercises, the researchers found a significant increase in the level of pain tolerance of those subjects who took the caffeine pills. The subjects also reported feeling more able to perform everyday activities like walking, sitting, climbing and descending stairs, otherwise known as all the shit you can't do the day after a suicidal workout without sobbing uncontrollably.
Keith Brofsky/Photodisc/Getty Images
"Working out is obviously bad for you."
Holy crap, the ads were right! Mountain Dew really can let you do extreme sports! Or, at least make you feel less like shit the next day.
And, in fact, if you're less the "damaging eccentric exercise" type and more the "sit your ass in front of a computer screen" type (hey, we know where you're coming from), there's still good news for you. In another study, scientists had volunteers perform 90 minutes of fake computer tasks similar to the everyday tasks you might perform at an office -- tasks meant to generate pain in the shoulders, neck, forearms and wrists of the volunteers. Before the start of the experiments, scientists allowed the volunteers to drink coffee ... not to study the effect of coffee on pain, but "to avoid unpleasant effects of caffeine deprivation, e.g. decreased vigor and alertness, sleepiness, and fatigue."
Jupiterimages/Brand X Pictures/Getty Images
"There's creamer in the fridge and heroin in the top drawer if you need some."
And that's when they noticed something unexpected in their results: The people who drank coffee reported a lower intensity of pain than the people who didn't. Whether or not the subjects reported chronic pain before the study, those who drank the coffee reported less pain on average than those who didn't. And there, dear Office Sociopath, is proof positive that you are causing your co-workers actual physical pain by not refilling the office coffee maker after you take the last cup.
4Look at the Part of Your Body That's Hurting
Jupiterimages/Goodshoot/Getty Images
Think about your last injury -- maybe the ramp-induced cracked rib you got trying to ramp several school busses, or perhaps you sliced your finger open while learning to twirl your butterfly knife around like a badass. Whatever it was, chances are you struggled between one of two natural human reactions: The first was to look at anything but the horror movie levels of gore suddenly spurting from your pinkie, while the other was to more closely inspect the damage to assess whether you'd managed to shatter your dreams of one day becoming a world-famous stunt driver slash professional knife fighter. Well, only one of those two reactions can actually reduce the amount of pain you'll feel.
This is another one of those times when you can take advantage of the oddities of your brain's wiring. While our previous article on the subject of pain pointed out how touching your wounds can help you mentally get a grasp on whatever pain you're experiencing, other studies have found that you can reduce the pain by simply looking at your own body.
Stockbyte/Valueline/Getty Images
"Hey, that works out great because I do that pretty much constantly anyway."
In one study, scientists created a mirror contraption that allowed them to manipulate what test subjects saw, and then got down to the science of causing pain to the test subjects' right hands using low-powered infrared lasers (because if you have "infrared pain rays" sitting around your lab, you need to use them for good before a superhero comes knocking). When participants looked at the reflection of their left hand (making it appear as if they were looking at their currently-under-laser-fire right hand), they were able to tolerate a significantly higher amount of pain than when looking at another object. And just to be clear, for the analgesic effect to be triggered, subjects had to be looking at their own hand -- looking at someone else's didn't work.
In a similar experiment performed on subjects suffering from chronic back pain, scientists studied how being able to see their back as they underwent a painful medical procedure affected how they perceived the associated pain. And what they found was that simply being able to see their back -- something that can be a challenge unless you're Mr. Fantastic -- significantly reduced the perceived amount of pain reported by the subjects.
Ciaran Griffin/Stockbyte/Getty Images
"Hey, this does work! My hands feel fantastic now!"
Scientists are still trying to work out just how this disconnect from the parts of our body that are experiencing pain affects our perception of said pain, but one thing's for certain: Your default reaction of staring at the ceiling and screaming for Mommy whenever something hurts isn't doing you any favors. If you get over your squeamishness and look at your horrible wound, it'll hurt less.


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