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The Secret to Happiness
I think I was happier when I drank Diet Coke.
For years, it was the first thing I consumed every single day of the week. When I worked at Southern Living, I would stop off at the ice machine for the rabbit-pellet ice (or Sonic ice) – best ice ever – fill up a cup, take it to my desk and pour that fizzing goodness to the brim. The ice machine is the thing I miss most about that job. (That and direct deposit.)
Sure, that daily Diet Coke was filled with artificial sweeteners that studies show can cause weight gain, metabolic syndrome, diabetes, and heart disease. Sure, diet soda consumption can erode teeth as much as crystal meth or crack cocaine.
But goddamn it was good.
Two years ago, I decided to give it up. It was horrible. I felt like I had the flu for the first few days. For the next few days after that I felt like I'd lost a dear friend. After about two weeks, I felt slightly normal again. Eventually, I didn't crave it at all and, on the few occasions I sipped a soda, it tasted way too sweet.
So, OK, yay for me and my healthy choices.
Except for this…the past two years have sucked ass. I've spent a large amount of time questioning my decisions and my judgment. Has my health changed? I don't know. I didn't have diabetes before and I still don't. I didn't have heart disease before and I still don't. I had awesome teeth before and I still do. I didn't smoke crack cocaine before and I still don't.
I'm thinking I should go back to starting each day with an ice-filled glass of delicious carbonated poison. I suspect it is the secret ingredient in making my dreams come true. It is the key to finally writing hit songs about everyone I've ever dated. Revenge is a dish best served in liquid form over Sonic-style ice in a glass. Drink that, douchebags.
To quote someone who is really quite wise, "Life's too short to worry about aspartame."
What wise person said that?
Sixth Grade Mix Tape
One day a couple of years ago, probably about the same time I was in heavy Diet Coke withdrawals, my sixth-grade boyfriend found me on Facebook and told me a truly horrifying story. I want to state for the record that I don't remember this incident ever happening. I probably blocked it out because I want to die of embarrassment thinking about it.
He approached me after math class one day and asked me to "go with him."
("Where are you going?" my mom would always say. "God! Nowhere, Mom!" Now, when Kate tells me she's dating someone, I say, "But you never even see him in person! Doesn't dating require going somewhere?" To which Kate responds, "Geez, Mom! You don't know me! You don't know my struggles!" And the world spins on…)
I said yes, of course, because I do remember his little sixth-grade self was adorable. He's still pretty damn adorable but with a lot more facial hair. In fact, a friend of mine has started jokingly pointing out good-looking guys in public and saying, "Look, there's somebody's sixth-grade boyfriend."
Anyway, that day after I said yes to going nowhere together, I went home from school…and then…what in the hell was I thinking…apparently, I called him and said, "I want to play you a song."
Seriously, I'm about to burst into flames of shame right now. My inner 12-year-old just ran into her yellow bedroom to hide in the closet.
I played him "Crazy for You" by Madonna.[youtube=http://www.youtube.com/watch?v=DHutZXREZ0E]
"So I sat there for the entire 4 minutes or so, during that fateful moment in a young boy's life, fending off constant ridicule and harassment from my mother, my brothers, and my neighbor friends (all boys), who just so happened to be there," he said, "I tell you, Amy, it certainly was a defining moment in my short and nearly innocent life.
"I don't know what, if anything, was ever said after that between you and me, but I certainly vowed to never ask another girl out ever again."
Can you blame him?
Recently, he told me it's still his favorite story to tell people, and I said, "WAIT! YOU'RE TELLING THAT STORY TO PEOPLE?"
So I'm telling it, too. Because someone who is really quite wise once said, "The greatest antidote to embarrassment is to immediately tell someone, 'Holy shit, I just did the most embarrassing thing.' Own your experiences. Those are your dumb, embarrassing stories. Don't let anyone else take them away from you."
What wise person said that?
When I was 12, I spent a lot of my time in my bedroom listening to my mother's old albums on my bright blue plastic record player. The Beatles' Rubber Soul. The hits of the early '70s. I also listened to cassette tapes on my boom box. Rick Astley was my first cassette. I was obsessed with Rick Springfield. I asked for a Belinda Carlisle tape for my birthday. Yep. The passage of time is a cruel bastard.
So, Derek, here are some more songs for your sixth grade mix tape. I hope you're sufficiently embarrassed now![youtube=http://www.youtube.com/watch?v=JIVYW977GVM] [youtube=http://www.youtube.com/watch?v=dQw4w9WgXcQ] [youtube=http://www.youtube.com/watch?v=NOGEyBeoBGM] [youtube=http://www.youtube.com/watch?v=N-tRXewCAmU] [youtube=http://www.youtube.com/watch?v=Ei9-zo20iMc] [youtube=http://www.youtube.com/watch?v=ccenFp_3kq8]
One Last Embarrassing Thing
And, finally, in ARE YOU FUCKING KIDDING ME news of the day:
This is the couple from The Bachelorette. If you'll recall, Chris wrote Desiree quite a bit of poetry while he was on the show wooing her. You know, stuff like:
Just kidding. His shit isn't nearly that good. (Credit for that poetry goes to the sick bastards of the Internet.)
Anyway, the couple has published a book about their great romance formed during six weeks on a reality show when Desiree was in love with this other guy who broke her heart and bowed out, leaving her sobbing at the end of a dock, so she settled for Chris. True love.
Chris is the true poet of the couple ("true" in that he insists on writing stuff and calling it poetry), but Desiree contributed some classic works to the book as well, and she writes, "This is a poem I wrote for Chris after our time we spent together in Germany. Relationships were developing and I knew Chris and I had something special so I wanted to share my feelings with him in writing. There are many hidden metaphors here so I hope you can find them and enjoy reading it as much as I enjoyed writing it!"
Charming and handsome, instant attraction was found.
At the dodge ball game, it was apparent-no shame.
On top of that roof, overlooking that view,
That was the moment, I knew sparks grew.
As our hearts are open, thoughts expressed,
Memories of lederhosen create a beautiful picture-
I must confess.
Still the twinkle in your eye, reflects your heart that's alive.
Never ponder why, trusting your every line,
Keeping in mind love can come at anytime.
The strength that you show, is the patience I know.
At times can be hard to withstand,
But I'm here holding your hand.
As the clock ticks, timing never late,
For the connections to form from each and every date
And the rose to one day grant us our fate.
I look forward to the unknown
Appreciate the emotion you have
And hopeful to see if in your heart,
I have found a home.
Oh my god, I hope you can find all the metaphors!
The first review on Amazon gives high praise to the authors for not wasting her time.
Because when it comes to identifying good books, you know it's good if your ass didn't have time to go numb while you were sitting down reading it.
And with that, my friends, I wish you a very happy Friday, and a wonderful Labor Day weekend that brings you all the Diet Coke, embarrassing declarations of love, and mediocre poetry you can stand. You know you want it.
Related link: Dear Diary – Middle School Is the Worst


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Member Kit
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subset: commoncrawl


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Holiday blues and a spike in suicides are often assumed to occur during the holidays. But, according to the Centers for Disease Control and Prevention, the supposed uptick in depression-related issues is just a myth. The challenges facing Texas' behavioral health care system, however, are not a myth. They include: • An insufficient workforce to …
Tag Archive: drugs
Permanent link to this article: http://www.easttexasreview.com/behavioral-health-care-needs-in-texas-are-no-myth/
Permanent link to this article: http://www.easttexasreview.com/lone-star-state-healthcare-there-is-no-place-like-home/
Feb 21 2012
That's what friends are for
By Susan Estrich Here we go again: a tragedy in the music world, a tragedy waiting to happen that did. Disturbing headlines before and after leave us scratching our heads and asking why. On the days before her death, Whitney Houston was disheveled, dressed in clothes that didn't match, hair dripping with water or sweat, …
Permanent link to this article: http://www.easttexasreview.com/thats-what-friends-are-for/
Aug 23 2011
Did John Lennon become a Christian?
By Jan White Recently, I saw a film producer interviewed on a network news program. He made a comment that fascinated me when he pointed out the possibility that John Lennon became a Christian during his later years of life. According to a soon-to-be-released documentary about the former Beatle and several biographers as well, Lennon …
Permanent link to this article: http://www.easttexasreview.com/did-john-lennon-become-a-christian/
Apr 14 2011
Panther posing
Spring Hill students won the Kids Press essay contest on why you should steer clear of illegal . Spring Hill State Bank and Gorman McCracken Volkswagen Mazda Dealership gave cash prizes to the teachers. Burger King rewarded all 80 students who participated in the contest. Thank you to the sponsors and congratulations to the winners.
Permanent link to this article: http://www.easttexasreview.com/panther-posing/


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Monthly Archives: February 2011
National Trust walk in Borrowdale, Lake District
Borrowdale is one of the slightly less well known gems of the English Lake District which gives some of the best views of any walk. This full details of this walk are published by the Daily Mail and created by … Continue reading
Spread a little magic this February with Keswick's Winter Week of Light …
Keswick Tourism Association is pleased to announce Keswick's Winter Week of Light- two magical FREE family events taking place in February half term. If you are looking for inspiration to entertain your family and friends during the holidays then Keswick … Continue reading
Torres Wine Evening at the Borrowdale Hotel …
Torres Wine Evening – Friday 4th March 2011 Nigel Harper our head chef has created a four course dinner which will be matched with a glass of Chilean wine with each course chosen by Stephen Wilcock Master Sommelier. The wines will … Continue reading


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Rockstar has given open access to a few select press outlets in New York interested in being the first to play GTA IV. Many of our favorite gaming blogs have gone live with their coverage of the multiplayer modes and the general concensus among them is WOW.
GTA has never been one for the multiplayer modes. The PC version of San Andreas had a hack that allowed you to go co-op in gang battles and the like thanks to a third-party add-on, but this being the first next-gen console version of the franchise, multiplayer has never been readily available.
But waiting has apparently proven advantageous. Being able to see where other multi-player modes succeed and fail has meant the Rockstar cats have had time and data with which to refine this aspect of the game. Some reviewers are even calling it the better half of GTA IV which has classically relied on its sand-box and mission based campaign modes.
Here's what some of our East Coast pals had to say about their hands-on experience with the game:
kotaku.com says: "All but one of the multiplayer modes supports up to 16 players. (The co-op missions only support up to four.) The host has an amazing array of options that they can control. While setting up a game, the host can choose to modify the routine, like respawn times, weapon selections and friendly fire, or the unusual, like the time of day, the weather, how heavy the traffic is or how many people are on the street. You can even control police presence in your matches.
"While the game allows you to select parts of the map to play in, choosing specific boroughs, smaller neighborhoods, or areas like the airport, it doesn't prevent players from roaming the entire city during any given match. Instead the respawns and weapon drops only occur in those areas."
destructoid.com says: "Before starting our gameplay session, we were given the option to modify our avatars appearance. Options like gender, face, hair, and clothing are all available at the outset with limited selections. We were told that these selections would be added as a player's rank up, between 0 and 10, which can be increased by picking up money across the game's various multiplayer modes.
"…it looks like Rockstar are looking to deliver a reasonably fleshed out multiplayer experience that shouldn't disappoint fans."
gamespot.com says: "While the Deathmatch modes were fun, the real attraction of GTA IV's multiplayer may well come from the many other modes that Rockstar has dreamed up. We wondered just how much of a role multiplayer would play in GTA IV, and after seeing it in action, we're pleased to report that it's far from being a simple afterthought to the game."
TheFeed says: "Dang, we jealous."
Looks like we're in for a hell of a treat with this whole GTA IV experience, ladies and germs. This is one blog that will be posting minimally on April 29 as we will have bought the game at midnight the night before and will be overdosing on nodoz and 17-hour energy powders instead of coming to work. This might happen all throughout May. You have been warned.
GTA IV Multiplayer Rundown
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Virtual Visa Debit FAQ:
International merchants (including US) Online, Over the Phone, and by Mail
Virtual Visa Debit is accepted by US and International online, telephone, and mail order retailers that accept Visa.
Canadian merchants Online, Over the Phone, and By Mail
Virutal Visa Debit is accepted online, over the phone, and by mail at participating online merchants in Canada. To date, more than 42,000 online merchants accept Visa Debit in Canada and the number keeps growing.
Virtual Visa Debit is available through RBC Royal Bank®.
Upon selecting items for purchase, you will need to:
The transaction will then be processed and completed.
to top
"Virtual" relates to the fact that this card can only be used where a card is not required to be physically presented to the merchant. These transactions are generally done online, by telephone or by mail order. For convenience, clients will be issued a plastic reference card that gives the client all the information required to make a purchase: The Virtual Visa Debit reference card does not have a magnetic stripe, CHIP or PIN associated with it and therefore cannot be used at an ATM or store.
to top
When making a Virtual Visa Debit payment, funds are debited from your primary chequing account. This is the same account that you access by selecting "Chequing" when you make a debit purchase with your bank card.
Yes. Some telephone and mail order merchants also accept Virtual Visa Debit payments. It is best to confirm acceptance with the merchant directly before submitting your Virtual Visa Debit information. Virtual Visa Debit can also be used for recurring payments with accepting merchants online, over the phone or through mail order.. Virtual Visa Debit cannot be used at physical store locations or at ABMs.
There is no need for a PIN because you cannot use a Virtual Visa Debit reference card at an ATM or at a store. The information located on your reference card is all you need to make a payment online, over the phone or by mail:
Yes. Shortly before your reference card expires, your financial institution will provide a replacement with a new expiry date (in accordance to their individual business practices). The expiry date is necessary to process purchases online, over the phone, and for mail orders.
For Virtual Visa Debit, the
Visa Zero Liability* policy provides you with protection against fraud for purchases made online, over the phone or by mail. Under the Visa Zero Liability policy, account holders pay $0 for purchases made through unauthorized account use. Account holders should report unauthorized transactions to their card issuer immediately. Within two business days, the issuer is obligated to provide provisional credit and replace the amount under dispute, in most circumstances. Account holders should be aware that transactions in question must be posted to an account before provisional credit is issued. For details, account holders should consult their issuers.
There are a number of relatively simple ways to help prevent fraud:
*Visa account holders must establish that the transaction is not their responsibility as per all applicable agreements of the issuing financial institution. Individual provisional credit amounts may be withheld, delayed, limited, or rescinded by an issuer based on factors such as gross negligence or fraud, delay in reporting unauthorized use, investigation and verification of claim, and account standing and history.
*Visa claim based upon global number of general purpose cards, number of transactions and purchase volume.


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\int is
You should write your rearrangement as
and then integrate. I'm not sure I buy your integration. Try again.
(except that you had "y" instead of "dy")
Now integrate both sides: the integral of a constant is that constant times x and the integral of x is
is correct. The integral of isbut cannot see where this 2nd part comes from.
My answer
Perhaps you misread the as .
is different from the solution in the book. The solution in the book is
can you show me where im goin wrong please. many thanks


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Current News
& Calendars
February 11, 2005
Penn Joins Major NCI Research
to Advance Breast Cancer Therapies
By applying new imaging technology and genetics,
researchers will better understand tumor behavior
and predict clinical outcomes
(Philadelphia, PA) – The University of
Pennsylvania School of Medicine was recently
selected to become a member of the National Cancer Institute's
Mouse Models of Human Cancers Consortium (MMHCC). The
MMHCC was established in 1999 to design and characterize
mouse models that more accurately reflect the way that
human cancers develop and respond to therapy. The research
groups comprising the MMHCC at 24 lead sites connect
more than 50 institutions in the US and abroad and focus
on mouse models for cancers of major organ systems including
prostate, breast, lung, ovary, skin, colon, brain, and
the blood and lymph systems.
Lewis A. Chodosh, MD, PhD, Vice Chair,
Department of Cancer Biology, Associate Investigator
in the Abramson Family Cancer Research Institute,
and Program Leader of the Breast Cancer Program at the
Abramson Cancer Center, heads one of
four MMHCC sites at which breast-cancer models are being
developed and studied. Chodosh will oversee a $2.5 million,
five-year program based at Penn that encompasses multidisciplinary
research from six institutions in three countries. Chodosh's
co-principal investigators are: Mitchell D.
Schnall, MD, PhD, Associate Chair of Radiology
at Penn; Robert D. Cardiff, MD, PhD, of the University
of California, Davis; and William J. Muller, PhD, of
McGill University.
The Penn Approach – A Focus on Breast
The goal of the Penn group is to develop new conceptual
and technical approaches for understanding the mechanisms
of breast tumor progression and metastasis. To accomplish
this, Penn researchers will employ a broad array of
state-of-the-art cellular and molecular imaging techniques
to analyze a series of novel, genetically engineered
mouse models of breast cancer. "It's truly
a multidisciplinary team effort, bringing together biologists
with radiologists, nuclear chemists, physicists, pathologists,
and computational biologists," says Chodosh. "This
type of endeavor requires a group of scientists with
a tremendous breadth of knowledge and expertise, which
this grant has allowed us to assemble.
"Understanding cancer biology and response to
therapy is so complex a challenge that it requires changing
the paradigm in which biomedical research is performed,"
explains Chodosh. "Traditionally, biomedical research
is performed by small groups of departmentally based
specialists working in relative isolation. In contrast,
the MMHCC is based on the premise that more rapid progress
can be made towards curing cancer by bringing together
scientists from multiple, disparate academic disciplines
to work synergistically in an interdependent manner.
Our group embodies that principle."
Specifically, the Penn MMHCC group will use a comprehensive
array of sophisticated technologies – including
positron emission tomography (PET), magnetic resonance
imaging (MRI), computed tomography (CT), magnetic resonance
spectroscopy (MRS), single photon emission computed
tomography (SPECT), and ultrasound – to visualize
and follow tumor cells in living animals from their
origins to their eventual progression to distant metastasis
and recurrence. The technology will also be used to
assess tumor response to therapy and to predict clinical
The mouse models for breast cancer to be used in this
program are unique in that the researchers can follow
the entire natural history of the disease in each animal
– from initial onset to response to therapy, tumor
dormancy and, finally, metastasis and recurrence. "This
process may take two years in a given mouse, which is
why using non-invasive imaging approaches to follow
the course of disease is so valuable," explains
Chodosh. "Overall, we are bringing imaging, genetics,
and cancer biology to bear on these end-stages of breast
Advanced stages of tumor progression, characterized
by resistance to therapeutic agents, metastasis, and
tumor recurrence, are responsible for the majority of
cancer deaths. However, while tumor progression constitutes
a problem of unrivaled clinical importance, the underlying
mechanisms are largely unknown. Shedding light on the
molecular and physiological events that contribute to
this process is a critical priority in cancer research.
"Genetically, we're trying to identify the
regulatory molecules responsible for the ability of
tumors to metastasize, recur, or remain in a dormant
state," explains Chodosh. "Imaging permits
us to ask such questions as: Can we predict what a tumor
will do in its natural history? Will it metastasize?
Will it recur? Will it respond to therapy? Will this
drug work or should we move on to the next drug?"
For example, using PET, researchers have already shown
that patients with a specific type of stomach cancer
who respond to the drug Gleevec show a dramatic change
in glucose metabolism within 48 hours of taking the
drug. In this way, imaging has provided a vital and
rapid indication about response to therapy and survival
that can be used to make decisions about whether to
change medication or not.
"With imaging you can look at metabolism, blood
flow, and numerous other physiological indicators important
in tumor biology," says Chodosh. "And, due
to the widespread clinical use of non-invasive imaging,
much of what we learn how to do in a mouse should be
translatable to patients."
Additional key investigators in the Penn MMHCC group
include Britton Chance, PhD; David Tuveson, MD, PhD;
Jerry Glickson, PhD; Paul Acton, PhD; Joel Karp, PhD;
Abass Alavi, MD; Chandra Sehgal, PhD; and Hank Kung,
PhD, as well as Ruth Muschel, PhD, at The Children's
Hospital of Philadelphia and John Condeelis, PhD, at
The Albert Einstein College of Medicine.
For more information on the MMHCC, go to http://emice.nci.nih.gov/emice/.
a printer friendly version of this release,
The Abramson Cancer Center of the University
of Pennsylvania was established in 1973 as
a center of excellence in cancer research, patient care,
education and outreach. Today, the Abramson Cancer Center
ranks as one of the nation's best in cancer care,
according to U.S. News & World Report, and is one
of the top five in National Cancer Institute (NCI) funding.
It is one of only 39 NCI-designated comprehensive cancer
centers in the United States. Home to one of the largest
clinical and research programs in the world, the Abramson
Cancer Center of the University of Pennsylvania has
275 active cancer researchers and 250 Penn physicians
involved in cancer prevention, diagnosis and treatment.
PENN Medicine is a $2.7 billion
enterprise dedicated to the related missions of medical
education, biomedical research, and high-quality patient
care. PENN Medicine consists of the University of Pennsylvania
School of Medicine (founded in 1765 as the nation's
first medical school) and the University of Pennsylvania
Health System (created in 1993 as the nation's
first integrated academic health system).
Penn's School of Medicine is ranked #3 in the
nation for receipt of NIH research funds; and ranked
#4 in the nation in U.S. News & World Report's
most recent ranking of top research-oriented medical
schools. Supporting 1,400 fulltime faculty and 700 students,
the School of Medicine is recognized worldwide for its
superior education and training of the next generation
of physician-scientists and leaders of academic medicine.
Penn Health System is comprised of: its flagship hospital,
the Hospital of the University of Pennsylvania, consistently
rated one of the nation's "Honor Roll"
hospitals by U.S. News & World Report; Pennsylvania
Hospital, the nation's first hospital; Presbyterian
Medical Center; a faculty practice plan; a primary-care
provider network; two multispecialty satellite facilities;
and home health care and hospice.


text:
Current Residents
Alfred Kaye, MD, PhD - PGY I
Al grew up in Los Angeles, and went to the University of California, Berkeley for his undergraduate degree in comparative literature and molecular cell biology. He worked in a lab at the University of California San Francisco looking at the molecular biology of acute ethanol adaptation before joining the MD/PhD program at the University of California, San Diego. During his PhD in neuroscience, he worked at the Salk Institute between the labs of Edward Callaway and Tatyana Sharpee to studying the microcircuitry and information processing of motion vision in the mouse thalamus using in vivo two photon calcium imaging. Al also developed a theory to show that thalamic relay cells are optimized to carry as much information as possible about motion. The work was supported by an F30 NRSA from the NIDCD. Al's vision is to apply cellular scale imaging and theory to the problem of how neural microcircuits adapt to traumatic events as a model of PTSD.
Brandon Kitay, MD, PhD - PGY I
Brandon was raised between Manhattan and Long Island before spending the second half of his life in sunny, south Florida. As a high school senior, Brandon was accepted into medical school through the prestigious Honors Program in Medicine (HPM) at the University of Miami; a combined program affording the completion of both a B.S. and M.D. degree within 6-years. As an undergraduate at "the U," Brandon further developed a life-long interest in Neuroscience through laboratory work. Under the mentorship of Dr. Mary Bartlett Bunge at the Miami Project to Cure Paralysis, he explored gene and cell transplantation strategies for promoting CNS regeneration following spinal cord injury (SCI). Beyond publications, posters, and undergraduate research awards, this experience revealed an underlying passion for biomedical research. With his penchant for combined degree programs, Brandon doubled-down and joined the University of Miami Miller School of Medicine's combined M.D./Ph.D. program after earning his B.S. in Biology at the age of 19. As a medical student, he held positions in the Department of Community Service (D.O.C.S.) aiding in the organization of student operated health fairs. As a graduate student, Brandon completed his dissertation in the laboratory of Dr. Grace Zhai. Entitled, "Mechanisms of NMNAT/WLDS mediated axon protection," his thesis work employed Drosophila and mammalian models to investigate the molecular underpinnings of nervous system maintenance in the context of neurodegenerative disease. During graduate school, he was awarded a Lois Pope LIFE Fellowship as well as the Edward J. Green Memorial Award for, "scholarship, citizenship, and service." Following re-matriculation in medical school, it was on his psychiatry clerkship that Brandon found his tribe within the realm of clinical neuroscience. As a resident in the NRTP at Yale, he hopes to further develop his skills as a physician-scientist with research and clinical interests in neuro-and geriatric psychiatry. Off-campus, Brandon can usually be found in the company of his four-legged sidekick, Bowie. He is also an avid skier, collector, and all around thrift store aficionado.
Youngsun Cho, MD, PhD - PGY II
Youngsun grew up outside of Rochester, NY and attended MIT for college. She initially entered the University of Rochester School of Medicine and Dentistry to obtain a MD degree, and then switched into the Medical Scientist Training Program (MSTP) to obtain a combined MD/PhD degree following her third year clinical clerkships. At that time she had decided on becoming a psychiatrist and wanted to learn about the brain. She completed a PhD in Neurobiology and Anatomy, and her dissertation work involved three studies aimed at understanding structural and functional connectivity within the brain. She published two neuroanatomy studies under the supervision of Dr. Julie Fudge at the University of Rochester: 1. dopaminergic inputs to the amygdala; 2. prefrontal and insula cortex inputs, and striatal outputs of the amygdala. Her third publication was a study of nucleus accumbens, insula and thalamus effective connectivity during reward processing in adults and adolescents using fMRI. This was carried out with Dr. Monique Ernst at NIMH. Her dissertation work was funded by NIMH under an F30 pre-doctoral fellowship, as well as by the Clinical and Translational Science Institute (CTSI). At Yale she plans to work with Dr. Alan Anticevic and to continue to use imaging modalities to understand the neural circuits that underlie emotion and cognition in psychiatric illnesses. She is grateful to the Yale psychiatry department for funding this collaboration with a Detre Fellowship.
Stephanie Yarnell, MD, PhD - PGY II
After graduating Summa Cum Laude with Highest Honors with 3 Bachelor of Science degrees, biology, microbiology, and ecology with the CURO Scholar Seal for undergraduate research excellence from the University of Georgia, Stephanie matriculated into a combined MD-PhD Program. She was the first scholar to participate in doctoral studies with the Emerging Pathogens Institute at the University of Florida, an institute that actively seeks to explore multidisciplinary and interdisciplinary research with her project concentrating on the interface of clinical infectious disease and environmental sciences. Here she eagerly embraced a project focusing on an important and understudied group of infectious diseases caused by non-tuberculous mycobacteria. Her talent and aptitude for quickly developing multidisciplinary skill sets and ability to identify important gaps in knowledge and unmet needs that could make important clinical impacts was demonstrated multiple times in her research. It is notable that her thesis committee advised she would be prepared to defend her thesis after only two and a half years of pre-doctoral research but, the earliest she could complete her PhD was after the third year. During these years, she drafted 3 papers for publication, presented at conferences, and her novel primer/probe set is being considered for patent by the University of Florida. Further demonstrating her excellence in research, she was awarded the American Academy for the Advancement of Sciences Excellence in Science Award and the Philanthropic Educational Opportunities Scholar Award. However, it was her research while a medical student that most motivated her. During her final year of medical school, Stephanie completed research on obesity and food addictions with Dr. Mark Gold, Chairman of Psychiatry. These endeavors lead to her first authoring a journal article, a book chapter, and writing the Yale School of Medicine's online curriculum for the Food Addictions. While both of the publications did not come out until she was in her first year of residency, she was able to establish a solid interest in obesity and the neurophysiology of feeding. It is that interest that she plans on pursuing in the NRTP research times.
Shelley Amen, MD, PhD - PGY III
After serving as a parachute rigger and jumpmaster in the 82nd Airborne Division at Fort Bragg, NC, Shelley graduated from Campbell University majoring in biology and psychology. Always interested in the molecular underpinnings of motivated behavior, Shelley joined the Medical Scientist Training (MD/PhD) Program at the Medical College of Wisconsin. There, she studied the neural substrates of drug dependence, specifically the network underlying potent cocaine craving. Under the supervision of Shi-Jiang Li, PhD in the Department of Biophysics, Shelley investigated cocaine-induced alterations in the mesocorticolimbic system and the utility of glutamate prodrug, N-acetylcysteine, as an anti-craving therapeutic. Under the guidance of Cecilia Hillard, PhD in the Department of Pharmacology, Shelley further studied the cocaine-induced alterations in the endocannabinoid system as a modulator of glutamate release and inhibition. Shelley described region-specific changes in cannabinoid receptors, endogenous ligands and their biosynthetic enzymes in the transition from the drug-naïve state to chronic drug exposure, withdrawal and relapse in a mouse model of cocaine dependence. This work was supported for 3 years by a NIH/NIDA National research Service Award (F30). Shelley plans to continue working toward developing additional strategies for substance abuse pharmacotherapy.
Alan Lewis, MD, PhD - PGY III
Alan grew up near Albany, NY and attended the University of Pennsylvania as an undergraduate, where he studied chemistry, math, and anthropology. At Penn he worked in the synthetic organic chemistry lab of Dr. Madeleine Joullie synthesizing natural products, until he ultimately became interested in neuroscience and decided to combine his interest in research with clinical medicine. He completed the Medical Scientist Training Program at Northwestern University, where he performed his doctoral work in the lab of Dr. Dane Chetkovich. His PhD project identified how an auxiliary subunit of HCN channels in the hippocampus regulates both channel trafficking and function, as well as how HCN channels may contribute to neurological and psychiatric disorders. As a member of the Neuroscience Research Training Program within the Department of Psychiatry at Yale, Alan has had the opportunity to combine clinical work in psychiatry with basic neuroscience research with Dr. Marina Picciotto. With Dr. Picciotto he is exploring how nicotinic acetylcholine receptors modulate aspects of aggressive behavior, with the goal of better understanding the circuit basis of aggression and potentially identifying novel treatments for patients. Clinically, Alan is interested in forensic and emergency psychiatry, as well as substance abuse. The NRTP has given Alan the support to explore both clinical and research areas, as well as strong mentorship to develop his research and career goals as a physician-scientist.
Adam Mecca, MD, PhD - PGY III
Adam attended the University of Florida as an undergraduate and graduated in 2005 with a degree in Chemistry and Microbiology. During these years, Adam participated in research that investigated the renin angiotensin system and cardiovascular disease. His research experience, combined with his work at a local student-run free clinic, Equal Access Clinic, stressed the importance of medical research for improving the health of our communities. He then trained in the MD-PhD program at the University of Florida where he continued to study the renin angiotensin system, but with a focus on the neurobiology of stroke. He published multiple articles in this field and completed his thesis titled, "Targeting the ACE2/Ang-(1-7)/Mas axis for cerebroprotection during ischemic stroke." In addition, he became deeply involved in underserved healthcare through volunteer and leadership roles at the Equal Access Clinic. These efforts led to a dramatic expansion the interdisclipinary services of this student-run free clinic. Adam has also been involved with the student-run free clinic movement on an international level and is a co-founder of the Society of Student Run Free Clinics, an organization whose mission is to promote student-run free clinic formation and information sharing worldwide. Adam's involvement in research and underserved medicine have shaped his interests in neuroscience and psychiatry. He is currently a resident in the department of Psychiatry at Yale and member of the Neuroscience Research Training program. His research focuses on Alzheimer's Disease and related cognitive disorders. He is also interested in cognitive disorders and related geriatric syndromes in chronically homeless older adults.
Daniel Moreno De Luca, MD - PGY III
After attending medical school at the Universidad Industrial de Santander in his hometown of Bucaramanga, Colombia, Daniel's curiosity about human behavior and his desire to experience the world through travel led him first to a Genetics fellowship at the Università di Bologna, Italy, where he studied the role of X-inactivation in families with autism and the genetics of suicide and personality disorders. Fascinated by the concept of psychiatric genetics, he then went to Paris, France, where he obtained his Master's degree in Neuroscience at the Université Pierre et Marie Curie and the Pitié-Salpêtrière Hospital, while he continued to investigate the genetic underpinnings of psychiatric disorders, particularly the role of anomalies in chromosome 15q11-q13 and 22q11 in autism and obsessive-compulsive behavior. Afterwards, he moved to the United States for a postdoctoral fellowship at Emory University to continue studying the genetic architecture of autism and schizophrenia, with a particular focus on copy number variants (CNVs), especially in chromosome 17q12, which led to several publications and a book chapter. Ultimately, Daniel decided to work directly with the people he studied; convinced he could make the biggest difference in the clinic, and sure of the research insights clinical interactions bring, he applied for residency training in psychiatry and is now honored to be part of the Yale psychiatry team and the Neuroscience Research Training Program. To continue developing his career as a physician scientist, he enrolled in the Investigative Medicine PhD program at Yale, where he hopes to continue understanding the genetic basis of neuropsychiatric disorders.
Albert Powers, MD, PhD - PGY III
Al grew up in nearby Northford, CT, and attended his local college, Yale, for his undergraduate studies.
During his first stint at Yale, Al took time away from singing with the Alley Cats and Whiffenpoofs to study Cognitive Science and do research with Dr. Laurie Santos, exploring aspects of object cognition and feature binding in capuchin monkeys.
During the year following college, Al worked with Yale Psychiatry faculty member Eugene Redmond, investigating the efficacy of fetal tissue transplants in Parkinson's Disease. In 2005, Al packed his bags and shipped south for the MSTP at Vanderbilt in Nashville, TN.
At Vanderbilt, Al's Ph.D. work was performed with Dr. Mark Wallace.
Together, and with NRSA funding from the NIDCD, they demonstrated that the cortical systems responsible for combining information from the auditory and visual senses are capable of rapid, robust, and stable plastic change as demonstrated by human behavioral and neuroimaging data, findings that could carry implications for a subset of psychiatric disorders exhibiting abnormalities in multisensory processing. Back at Yale, Al is enjoying the clinical training afforded by intern year but simultaneous aching to be back in the lab exploring the subtle differences in brain connectivity that may underlie much of psychiatric disease.
Rajiv Radhakrishnan, MBBS, MD - PGY III
Rajiv completed medical school and psychiatry residency training in India. His research interest was initially piqued by the varied clinical presentations of schizophrenia that he saw in the clinic. His desire to obtain research training took him to India's premier neuroscience institute, the National Institute of Mental Health and Neuroscience (NIMHANS) where he worked on a research study examining the effects of D-Serine augmentation of cognitive remediation in schizophrenia. Rajiv moved to the US in 2010 in order to pursue a postdoctoral research fellowship at the Schizophrenia Research Clinic (PI: Deepak Cyril D'Souza) at Yale which has been a pioneer in examining the contribution of the cannabinoid system to psychosis. During his time as a postdoctoral fellow, he examined the effects of pharmacologically induced GABA-deficit on psychotomimetic effects of delta-9-tetrahydrocannabinol (THC), a cannabinoid partial agonist. Rajiv came back to Yale as a PGY-II psychiatry resident and is currently a PGY-III at our program. Rajiv is supported by the NRTP IMPORT grant and the APIRE/Janssen research award this year to continue his research on the effects of THC on information processing as is relevant to psychosis.
Samuel Wilkinson, MD - PGY III
Sam was born in Salt Lake City, Utah but moved at a young age to Northern Virginia. He attended Brigham Young University where he studied Mechanical Engineering (minor in Chemistry). During his undergraduate studies, he spent a summer as a research assistant at the Center for Biological Engineering at MIT, exploring the effects of cytokines and compressive injury on the gene expression of articular cartilage. After exposure to patient care when he volunteered at a hospital in Boston, he decided to modify his career plans and pursue a medical degree. Upon graduation, Sam began medical school at Johns Hopkins University School of Medicine in Baltimore, intending to pursue a career in otolaryngology. During his first year, however, his plans again changed after his introduction to psychology and psychiatry course, in which he became fascinated by the mystery surrounding the mind-brain problem. During his medical school training, he conducted research in Obsessive-Compulsive Disorder in people with developmental disabilities and earned the Doak Walker Award in Psychiatry for his research efforts. His research mentor at Hopkins was Marco Grados, MD, MPH. Upon graduation, he was awarded the Samuel Novey Prize in Psychological Medicine. His current research interests include treatment-resistant depression and the therapeutic potential as well as adverse effects of cannabinoids.
Benjamin Kelmendi, MD - PGY IV
Ben left his native country Kosovo at age 17 to come to the states to pursue his dream of becoming a physician. After graduating from college, where he studied psychology and biology, he took a position as a research assistant at the Yale OCD Clinic. While working as a research assistant, he developed his research interest in OCD. After medical school, he returned to Yale for residency to pursue his research interests in Psychiatry. He's currently working on developing new symptom provocation paradigms used to elicit OCD symptomatology. Ben is also deeply interested in the phenomenology of OCD and actively pursuing qualitative research in this area. Ben has a deep passion for philosophy; he's an integral member of the Philosophy and Psychiatry group.
Sarah Fineberg, MD, PhD - PGY V
Sarah first thought she might become a doctor at Oberlin College, where she had the most fun taking physiology courses and talking about social justice late at night. She went on to the University of Iowa MSTP, where she investigated the role of microRNAs in neural stem cell differentiation in Beverly Davidson's lab, and helped to develop free medical and mental health clinics in Iowa City. She joined the adult psychiatry residency and neuroscience training program at Yale in 2010. During clinical training, her interests have moved toward social cognition. Together with her mentor, Dr. Philip Corlett, she has begun to learn methods in cognitive neuroscience and clinical research and has begun two lines of work that I hope to develop toward a clinical research practice dedicated to ameliorating social dysfunction in mental illness using approaches grounded in translational neuroscience. First, she uses psychological tasks to quantify social learning and embodied cognition in people with psychiatric illnesses characterized in part by social dysfunction, such as Borderline Personality Disorder and psychosis. She aims to combine this approach with pharmacological models and neuroimaging to better define timecourse and circuitry relevant to this process. Sarah has also begun to employ computational linguistic tools to examine the language of people with mental illness. She has studied published first person accounts of psychosis, and is now beginning to analyze speech changes across illness trajectory and in the context of specific circuit disruptions.


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The New England Patriots will take a gander at the available talent before the Week 8 NFL trade deadline expires. Although, it remains to be seen whether the team is shopping, or just browsing.
The last time the Patriots made a legitimate move at the deadline, it was 2010. Wide receiver Randy Moss was shipped out to Minnesota and Deion Branch was reeled back in from Seattle.
Could another surprise move be on the horizon? At this point, it's mere speculation. But if the Patriots are in fact looking to get a deal done, what sort of players could be on the market?
Director of player personnel Nick Caserio and head coach Bill Belichick certainly have some decisions to make. Here are five moves to ponder.


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|Date added:
|October 26, 2012
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The head of a council-funded organisation has defended his decision to hire a teacher who was struck off for having sex with a teenage pupil.
Eppie Sprung Dawson, 27, is now working for Third Sector First, based in Dumfries, as an administration assistant.
The organisation, which runs training for charity and volunteering agencies in the local area, works with the Saltire Awards, which encourage volunteering among 12 to 25-year-olds.
Sprung Dawson, who taught English, was caught with Matthew Robinson — who was 17 at the time and naked from the waist down — by a police patrol car, on the evening of


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Do you want much more useful data or articles? Olympic Soccer Darkish Horse TeamsSame Previous Tale in Euro 2012
And in UEFA's 2012 European Championship, replays demonstrate that Ukraine scored to level the game from England and nevertheless the objective was not awarded. The aim was not as distinct at entire velocity as the one particular two several years before but aim-line engineering would have witnessed it given.
Hitherto, FIFA has resisted the introduction of aim-line engineering but its positive aspects are not able to be denied. Movie referees have been introduced into rugby league in 1996 when they have been utilized in Europe's Super League. It was subsequently adopted by the Australian Countrywide Rugby League with excellent effect. The match referee can question the "online video ref" to rule on a number of matters to make a decision if a consider really should be awarded: has the ball been grounded effectively was there a knock-on was there an off-side did the player phase into touch and, was there any obstruction?
Introduction inside Rugby Helps Officers
Rugby presented goal-line technological innovation in 2001. Referees can phone on the online video official, known as the "television match official" or TMO, to seek advice from on decisions relating to the scoring of a attempt or a kick at objective.
The use of objective-line engineering will help match authorities make the right choice. At times their view is obstructed or else a get in touch with is marginal. And players can not be relied upon to assist as they, as well, typically can not tell what has happened with any certainty, assuming that they are prepared to be entirely honest in the very first area.
Purpose-line engineering is not always foolproof, nonetheless, and mistakes are still made but the number of mistakes is being lowered and frequently a replay exhibits an aspect of an accessoire that players were unaware of and would or else have disputed. In most circumstances, therefore goal-line technological innovation is helpful for the game.
A single can only question why it is taking so prolonged for football to embrace purpose-line technological innovation. The FA in England has ideas in place to introduce the technology in 2013 and, with the latest accessoire even FIFA President Sepp Blatter has at lengthy very last admitted that something wants to be accomplished.
Will Engineering Gradual Down the Video game also Significantly?
But there are nevertheless people who oppose the idea, arguing that human mistake is portion of the video game and that football's flowing nature would be influenced if purpose-line technological innovation have been to be launched. On near evaluation, nevertheless, this situation is hardly tenable. In the interests of the game mistake on the part of officials requirements to be decreased to a minimal, which the technologies will let, and there should be no need to have to halt the recreation to evaluation a choice.
Would you like much more useful data or guides? Ought to Soccer Use Purpose-Line Technology Like Rugby?
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Wellness·May 31, 2013
Fat Talk, Old Talk...Does All This Negativity EVER End
You've probably done it. Maybe even this past weekend. Hell, maybe even today. It always starts out innocently enough. One person says, "Oh my god, I ...
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(based on 13 reviews)
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Reviewed by 13 customers
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(1 of 1 customers found this review helpful)
Great for Using with my phone
By JDF
from Undisclosed
Comments about Bose - SoundLink Around-Ear Bluetooth Headphones - Black:
I bought these last year on my birthday for myself. When I am mownig the lawn it is wonderful. I put my phone in the little dashboard on my tractor and don't have to worry at all about the cord getting tangled in the wheel or me getting off and forgetting I'm attached to the phone. It also rings in when I get a call so I can pick it up and talk and then goes right back to my music! I absolutely love them and am now getting a pair for my son to use with his computer.
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(3 of 4 customers found this review helpful)
Worth the money
By Chessie731
I bought it last year for my birthday, it was the best investment in headphones I could purchase. The sound was so clear and crisp. At first I thought the sound was kind of low ,but then I realized, when I used the Bluetooth piece the sound was a little lower then using the cord. The sound was awesome because it was over powering in your ear.
(3 of 3 customers found this review helpful)
Loud & Clear
By GreenThumbSD
I just bought these and used them on a conference call. I needed the bluetooth function because my phone's 3.5mm jack is less than perfect. For my hour long conference call I turned up the volume which is plenty loud. The whole experience went as expected--smooth and without a hitch. At first I wasn't going to buy them because they don't have a mute function, but then I realized how easy it is to mute my phone instead.
Amazing sound and wireless
By Bostonblocker
I've had these over a year, and I am beyond thrilled with them. Light weight, super comfortable, amazing sound quality and wireless freedom. Read reviews where people criticized the volume and I have had zero issues with that. Whether on a plane, at home (wife can't stand them because the headphones do such a good job of blocking sound around me, I can't hear her) or doing yard work, I hear perfectly fine, even over my lawnmower. Also works great as a wireless headset, people always compliment how great I sound.
(6 of 6 customers found this review helpful)
Best Headphones Ever!!!
By John
I Bought These Headphones A Few Day Ago And The Sound Was Pretty Good But The Quiet Confort 25 Sound Is Better But I Just Found Out That You Could Use It Two Ways A Non-Wirless Way Or A Wireless Way , The Battery Life Is Really Good Last Up To 7 Hours And The Charging Time Is Only About 3 Hours I Really Like These Headphones. Oh! One Question Why Did Bose Stopped Making This Headphones?
(2 of 3 customers found this review helpful)
Detailed but colored sound
By audiofool
Got these as a gift so had no preset expectations when I received them. I have several "tethered" headphones and headphone amplifiers so plenty to compare to. Overall these are musical, good for a casual walk or lounging about, no aggressiveness in the highs but a bit rolled off in the bass.. They don't isolate so a windy day or loud noise in the environment can be heard over your music (which is a safety plus!!!). I found I preferred the sound of the wireless amp vs. using the supplied alternate cable with iPhone
(4 of 6 customers found this review helpful)
By Dman1231
I was skeptical after reading how they don't sound good and because they are Bluetooth the sound is flat but once I put them on ( surprisingly comfortable) and played songs I was so excited because of the clarity of sound without the restraint of the wire. (Brw removing the dongle is kinda hard)
(11 of 11 customers found this review helpful)
By George
Bought these a month ago and the sound quality is marginal, the signal is intermittent more than 5 feet from the bluetooth source, and I cannot remove the wireless gizmo from the earphone to connect directly. I have had Bose products for at least 20 years. THIS is disappointing, very disappointing.
Bluetooth a disappointment
By Disappointed
My headphones only work well when I am 10 feet away and one side facing my satellite transmitter. If I walk too far away or turn the wrong ear towards the satellite music stops. Too much money for poor performance. Have been a staunch Bose fan for decades, but not so sure now.
(7 of 7 customers found this review helpful)
Stand with built in charging & 100 Ft Range
By Bose Research Scientist
These headphones are GREAT. However, these headphones needs improvements. First, stand where you hang these headphones and it charges headphones automatically. Sony has several headphone models with Stand with built in charging. Second, these headphones need range of at least 100 Ft Range. 30 Ft is NOT enough
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