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By Don McAlavy: Local Columnist
Sam Walton was born in Kingfish, Okla., on March 29, 1918. He graduated from the University of Missouri in 1940. From there he began his career by opening the first of several Ben Franklin franchises in Arkansas. Finding that he couldn't manage these franchises as he thought best, he gave them up and sought greener pastures.
In the northwest corner of Arkansas, he opened his first Wal-Mart in the rather small town of Rogers. In his retail store his idea was to charge low prices for his merchandise and that soon became a model for all his Wal-Mart stores to follow. "Sell name-brand merchandise at low prices," he said.
Only a few people know how officials in the first Wal-Mart store (1962) learned to handle money that went to the bank. Opal and H.E. "Shorty" Baldridge moved to Rogers, Ark., in 1948. ("Shorty" Baldridge had graduated from Clovis in 1929).
Opal loved to tell this story:
She was working the drive-in window at the bank. The manager of the first Wal-Mart brought the money in a paper bag and put it in her drawer at the drive-in to deposit. They had not sorted bills nor change, and did not have a total. Opal prepared their deposit and gave them instructions on how to make deposits. (Opal died at 94 on Dec. 9, 2005, in Walhalla, S.C.)
Wal-Mart had more than 300 stores in the 1980s and more than $1 billion in sales. In 1991, Wal-Mart was the largest retailer in America with 1,700 stores.
Sam Walton was active in the company as CEO until 1988 and was the chairman until he died in 1992. He received the Medal of Freedom. Walton was the world's second richest man (Bill Gates the richest) when he died. He handed down the company to his three sons, daughter and wife. One of his sons took over as chairman of the board.
Wal-Mart's success was mainly due to the discount concept. Frank Woolworth, in 1879, made his Woolworth stores that covered America, the original giant retail empire, as Wal-Mart is today (this information from Bob Batchelor of the History News Service). Other discount stores failed because they didn't adopt technological innovation quickly enough or because they pursued ill-advised diversification projects.
The problem that sunk Woolworth executives was they couldn't imagine that Kmart would upend their company. Kmart never really viewed Wal-Mart as a threat in the 1960s and 1970s. Will there be a retailer that can out-Wal-Mart Wal-Mart? The answer is probably yes, reported Bob Batchelor.
"Looking back at the history of discount shopping in America, it's easy to visualize a line from Woolworth's to Wal-Mart. Today's discount retailers use the same methods Woolworth pioneered. They build stores in prime locations, squeeze distributors and offer low prices. Wal-Mart has mastered its gargantuan supply chain and used its size to force vendors to cut their prices. Technological innovations have driven down overhead. Savings have then been passed on to shoppers. Wal-Mart's high-tech infrastructure is the real engine driving the company's revenues. The economy goes as Wal-Mart goes," said Bachelor.
"Will Wal-Mart do something visionary or risk eventual extinction as did Frank Woolworth's great innovative retail enterprise? It's not unreasonable for the world's largest company to aspire to be its most compassionate. That might make Wal-Mart a place where people would want to work — and love to visit again," ended Bachelor.
Wal-Mart came to Clovis with groundbreaking on Jan. 10, 1985, with the event of North Plains Mall.
Some items from Sam Walton's 10 Commandments of Retail: Share your rewards, deliver more than you promise, work smarter than others and blaze your own path.


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By Al Niederfringer and Lee West
When their business burned to the ground despite code-compliant sprinklers and noncombustible building materials, the owners of a retail store learned the hard way how a seefmingly small oversight can result in a big loss.
The problem? A valve buried beneath the asphalt street controlling the flow from the public main into the store had never been fully opened after repairs to the public water system were completed. When the automatic sprinklers turned on, there was no water to feed them. The fire engulfed the store's highly combustible goods, and the building collapsed before firefighters could save it.
While, fortunately, no one was injured, the loss topped $4 million - an expensive lesson about the importance of not just installing fire-protection devices, but also inspecting, testing, and maintaining them on a regular schedule.
The best and most advanced fire-protection devices are of little use if the human element - human action or inaction - isn't taken into account and addressed on a planned, periodic, and proactive basis.
Fire Remains a Threat
In this country's early years, before advances in fire-safety technology, fire could - and often did - sweep through a community, completely destroying homes and commercial buildings. Even just a century ago, death and devastating destruction from fire was much too common. The 1906 fires that followed the massive San Francisco earthquake gutted 28,000 buildings and killed 3,000 people. In 1911, New York City's infamous Triangle Shirtwaist Factory fire killed 146, mostly young women trapped by locked doors and missing fire-escape ladders.
These and similar disasters have led to increasingly stringent fire-safety standards and prescriptive building codes that, today, have made buildings much safer. The record for nonresidential structure fires is getting better - an improvement that the Emmitsburg, MD-based U.S. Fire Administration attributes to an extensive focus on protecting public and private buildings with rigorous standards. According to the U.S. Fire Administration, in 2006, there were 111,500 fires in nonresidential structures, killing 85, injuring 1,425, and causing $2.65 billion in property damage. This compares favorably to a decade earlier, when there were 145,500 nonresidential fires, 120 deaths, 2,600 injuries, and $2.5 billion in damages.
Focusing on the Physical
Many of the improvements in fire safety have come from physical requirements in terms of how buildings are constructed and equipped. Today's fire-safety measures often include automatic fire-sprinkler systems, fire pumps, alarm systems, portable fire extinguishers, fire walls, and requirements for noncombustible materials.
Protective measures are becoming increasingly sophisticated and complex. For example, specialized fire-extinguishing systems fixed permanently over cooking equipment are designed to automatically respond to a fire in a grill or deep fat fryer. These systems detect fires quickly, turn off heat sources, and discharge appropriate chemicals to extinguish fires - all without the often-too-late intervention of a human being.
Building design has also improved, often incorporating features, such as protected stairwells, that give occupants smoke-free escape routes, specialized fire barriers, and smoke-control systems.
The All-Too-Human Issues
Despite improvements in design and protective devices, no building is completely fire safe. One of the biggest threats comes from the human element of fire safety. The best protective measures will not be effective if they don't work when they're needed - and, most often, they fail because of human error.
Unfortunately, some examples to illustrate this are easy to come by:
Big-picture problems can have a big impact on fire safety. But, there are many smaller issues that exist - and only increase in scope—when a fire occurs and systems do not respond as designed. How common are these problems? Insurance risk control specialists often uncover what are called "hidden impairments" (conditions that place millions of dollars' worth of property value at risk because of undetected problems with systems that are supposed to take over during emergencies). The charts on this page show the breadth of problems discovered by just one insurer.
As the 2007 pie chart illustrates, more than two-thirds of problems discovered by insurance risk control representatives come from valves that have been shut down and never reopened, often during the repair or testing of water systems. Fire pumps that fail to start when needed are another major source of risk. Problems with alarm systems, and failures involving dry pipe valves (DPVs), which are critical components of dry sprinkler systems, are also frequent.
Taking the Right Steps: Fire-Safety Plans
There need to be visible commitment and demonstrated support from top management for fire safety to be taken seriously. It's important to develop a fire-safety plan, including elements such as emergency procedures, evacuation plans, and fire drills that are designed around the specific hazards of a business.
The top-down commitment begins with appointing a person or committee to be responsible for the creation and implementation of the fire plan. This fire-safety manager or committee needs to be held accountable for ensuring that the plan is followed, not just shelved. In addition to following the plan's strategy, the fire-safety manager needs to be aware of when conditions change - a building remodeling or a shift in business operations - and focus on the implications from a fire-safety perspective.
Once this is complete, a framework for inspection, testing, and maintenance should be embedded in the fire-safety plan and followed rigorously:
Inspection. The fire-safety manager should routinely inspect the building to make sure that general housekeeping is up to standard. For example, combustible liquids (ink at a printing business, cooking oil at a restaurant, or paint at almost any business) should be stored in proper containers and protected areas. Ducts and exhaust hoods above cooking equipment should be inspected for grease build-up that might feed a fire, and should be cleaned frequently.
The fire-safety manager should also plan to review conditions in the aftermath of a building remodel to make sure that any fire-protection systems that were temporarily out of commission are restored to working order. The manager should be made aware of changes in business operations, such as new warehousing procedures, that may impact fire safety.
In addition, it's important to ensure that occupants follow whatever smoking controls have been established: This may include making sure that smoking only occurs in designated areas and that employees are leaving the building to smoke.
Since many businesses are too small to hire a full-time fire-safety manager or officer, they should be aware of resources they can tap to help the person they designate for this role - this person may have many other responsibilities and little formal fire-safety training. Some insurers have risk-management operations that provide their customers with training on inspection and maintenance techniques. Local fire departments are also sources of expertise; having them become familiar with a facility prior to an emergency is always a plus.
Testing. All systems should be tested on a regular basis. In many cases, quarterly or annual tests are best conducted by outside experts or contractors, but it's up to property managers and owners to monitor the results and act upon recommendations.
In addition, weekly and monthly testing can be conducted by people on-site. For example, the following test frequencies are recommended for an effective sprinkler system:
Another important duty of the fire-safety manager is to make sure that the right people are notified during testing if systems are shut down. Local fire officials and the agent or carrier for the fire insurance should usually be alerted to the timing and duration of water-supply shutdowns.
Maintenance. For inhabitability, it's important to maintain all building systems in good working order - particularly so when it comes to fire protection. Fire pumps, for example, can mean the difference between having enough water to douse a fire before it becomes fully involved or helplessly watching a building engulfed in flames. But, a fire pump is of little value if it doesn't start when it's needed because its controller deteriorated and was never tested.
The Quincy, MA-based National Fire Protection Association has issued a number of standards (available online) for testing, inspecting, and maintaining fire-prevention features and equipment, such as portable fire extinguishers, sprinkler systems, fire alarms, and fire doors. In addition, the risk-control services of insurance companies and local fire marshals are good resources for maintenance tips.
Innovative measures can help identify areas for building maintenance that can make a difference in fire safety. Infrared thermography, for instance, can be used to locate problems with electrical equipment. Infrared scans can detect electrical hotspots that are wasting energy and producing excessive heat that may lead to fire. In addition to forestalling fires, finding and fixing poor electrical connections before a component fails can save occupants the costs associated with manufacturing downtime and other losses related to electrical outages.
Ultimate Responsibility is Shared
In the aftermath of a fire, there may be finger-pointing and accusations about who should have done what. The tenants may presume that the building manager was taking care of annual inspections. The building manager may rely on a fire-safety contractor without bothering to pay attention to the details of reports dutifully filed away. The building owner may think that complying with building codes during construction completes his/her responsibility.
Obviously, it's much wiser for everyone with an interest in the building to use common sense, take proper preventive measures, and practice constant vigilance. Fire safety isn't one person's job - it should be a cultural value with a commitment to follow through on issues as they arise.
Fire suppression and detection systems in today's buildings are innovative and highly effective - but only if they're inspected, tested, and maintained so they work properly when the need arises. Those who own, manage, and inhabit buildings have joint responsibility - a responsibility they can fulfill by working closely with experts, including local fire departments and insurance risk control consultants, to make sure they're ready if and when a fire breaks out.
Al Niederfringer and Lee West both work for Hartford, CT-based Travelers, the second-largest writer of commercial U.S. property casualty insurance. Niederfringer is second vice president and West is managing specialist for Travelers' risk control department.
Whether you need to heat, cool, power, sweep, lift or reach, Sunbelt Rentals has the equipment and unlimited solutions to solve any challenge. 24/7. Nationwide.

subset: commoncrawl


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The Joy of Capital Spending
India's Top 20 Pharma companies are upgrading facilities to proactively enjoy Pharma market opportunities
India's top 20 pharmaceutical companies are increasing capital expenditures by 40 percent to take advantage of market opportunities to come, says a report from CRISIL, a global analytical company providing ratings, research, risk and policy advisory services. The article, which appeared on The Economic Times of India website, attributes the CapEx increase in India to the fact that the country's "drug makers are expected to pay greater attention to regulated markets, especially the U.S. market, and to take advantage of substantial patent expiries expected in the medium term, as well as an ever-increasing demand for generics."
There's been no shortage of criticism of India's pharmaceutical industry and its drug-quality lapses. A…
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EU Certifies Vetter's Supply Chain is Better
Authorized Economic Operator FullRecognizes Company's Operational Excellence
Vetter, well-known CMO and experienced aseptic parenteral processor, recently achieved Authorized Economic Operator Full (AEO-F) status from the European Union. Internationally accepted, AEO-F certification affirms that Vetter maintains the highest reliability, solvency and safety standards in international pharmaceutical trade. The AEO-F certificate is currently accepted by the U.S. and Japan, the EU Member States, Switzerland, Norway and China.
According to Vetter, the certification facilitates the import of drugs in third countries and confirms the quality, reliability and performance of its entire supply chain. Equipped with the AEO-F, customs procedures associated with consignments will be simplified and accelerated, "all of which…
Advanced Filtration Optimizes High-Viscosity Blow-Fill-Seal
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Mature Quality Systems: What Pharma Can Learn from Other Industries
Pharma can take inspiration from industries with mature quality systems and advanced quality capabilities
Quality has a special meaning in pharmaceuticals, where production or distribution errors can jeopardize human life. But other industries face similar challenges, and some have developed sophisticated quality systems. As pharmaceutical companies look for ways to improve their quality practices and performance, they can take ideas from these quality leaders and adapt them for pharma.
Quality can be defined in various ways, from "fitness for purpose" to "meeting customer expectations" to predictability in statistical terms. Each industry understands quality differently, and priorities depend on the specifics of products and markets. In the automotive industry, for instance, companies generally define quality as the ability to meet…
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For pharma operations, the question isn't "When to go digital?" It's "How fast can we get there?"
Industry after roiled industry is being transformed as digital innovation becomes the mother of new methods, efficiencies - and businesses.
In pharmaceuticals, the first wave of the digital revolution has largely been focused on using technology platforms and data analytics to better understand customers, increasing patient engagement and developing new go-to-market approaches.
Change in pharmaceutical operations has proceeded more cautiously, partly because in a supply chain already complicated by so many country-by-country regulations, rising quality-control scrutiny, more complex product portfolios, increasingly competitive pricing, an ever-widening universe of supply chain partners and the threat of counterfeiting, the hurdles to…
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Serialization and regulatory compliance strategies pharmaceutical manufacturers should consider when addressing supply chain security
To combat potentially unsafe counterfeit drugs and product diversion, the FDA passed the Drug Supply Chain Security Act (DSCSA) in 2013, creating federally mandated requirements for traceability of pharmaceutical products. Fast approaching is a November 2017 DSCSA compliance deadline with additional serialization requirements. While the disruption to existing manufacturing and distribution processes will be significant, it is vital to impose supply chain visibility to prevent diversion and counterfeit products from reaching consumers.
PMMI sat down with Steve Peterson, product manager at the Peterson Group and Mario Simard, senior product line manager at Optel Vision to discuss what strategies pharmaceutical manufacturers should…
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Make sure the pressure transmitters used in your CIP/SIP application are designed for that service.
In a perfect world, all the instruments used for process control would maintain their specified accuracy under any and all conditions short of damage, and maintain the same accuracy for the same process variable value regardless of what happens between measurements.
Figure 1. Repeated exposure to the high temperatures involved in CIP/SIP can cause a pressure transmitter not specifically designed for such conditions to drift out of calibration.
In the real world, instruments' characteristics change, even if only slightly, as their operating conditions change. In sanitary processes subjected to clean-in-place (CIP) and sterilization-in-place or steam-in-place (SIP), instruments must withstand rapid changes in temperature and pressure…
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The FDA has approved -- for the first time in history -- a manufacturer's production method change from "batch" to continuous manufacturing.
Click image to enlarge
Yesterday, Lawrence Yu, FDA's Deputy Director, wrote a blog post about a landmark event for continuous manufacturing.
The FDA has approved -- for the first time in history -- a manufacturer's production method change from "batch" to continuous manufacturing.
This new approval is for manufacturing Janssen Products' medication for the treatment of HIV-1 infection, Prezista (darunavir), at Janssen's Gurabo, Puerto Rico, plant.
While even the FDA admits the transition from batch to continuous is "not easy," the agency is encouraged by the fact that it is seeing a growing number of manufacturers working towards building continuous manufacturing into their processes.
For Janssen, the decision to introduce CM…
Smart Manufacturing, FDA's Vision for Quality
IFPAC 2016 Conference
Ready, Aim, Aim, Aim … Still Aiming
Why so many pharmaceutical companies can't "just do" PAT
The PAT (draft) Guidance was introduced in 2002, finalized in 2004, and is still largely ignored as an option by a huge number of pharma companies. Why? That is a simple question with a multi-faceted answer.
Having said that, let's look at the money involved. PAT will cost money and time and, as the old saw goes, "time is money." Having the money and allocating it are two different matters. While the industry still makes huge profits, it also still uses antiquated accounting and payment practices. Add to that it also considers cross-training, instrumentation/short courses and conferences as "overhead" and not necessary for this quarter's profit.
Also, largely still in place, is the "justification" of capital spending. At…
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BRIEF: Advances in Process Analytical Technologies
Pressure Regulating Valve Family
Full Name: Pressure Regulating Valve Family
Team: GF Piping SystemsStatus: Elastomer Free
Debut: January 2015
Field Position: High purity piping systems
Skill Set: Engineered modular design and materials eliminate particle shedding
Performance Stats:• Elastomer-free proprietary piston design• Modular design and cartridge makes valve function switches easier• Central housing nut does away with re-torqueing
Regulatory Profile: Suitable for high-purity system duty and GMP-based processing.
Coach's Notes: "Our new Pressure Regulating Valve family offers solutions that no one else in the PRV market offers," says Jeff Sixsmith, Product Manager for Valves and Actuation for GF Piping Systems. "The piston design…
Pall Life Sciences Wins Interphex Best-in-Show Distinction
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Intelligent Data Application and Management Will Define Pharma's Future
The next decade of drug development will be based upon new and more effective means of data mining and data analytics
The pharma landscape is evolving as rapidly as the speed of technology. The industry that former FDA Commissioner Dr. McClellan admonished in 2003 with, "You need to improve!"1 has taken those words to heart to embrace innovation and technology as never before. Whether motivated by the FDA's shift toward a scientific, data-driven definition for quality or a need to innovate to survive and be competitive in the new world marketplace, there is no doubt the push for greater understanding has resulted in a renewed emphasis on the ability to acquire, verify and leverage the power of data.
THREE DRIVERS FOR CHANGEEvery market sector needs a push sometimes to adapt and evolve. The regulated life sciences are one of the most conservative…
Gemini Analyzer
Study Says Published Papers Fail to Report Clinical Trial Violations
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New xCELLigence RTCA CardioECR is the first platform for simultaneous measurement of Cardiomyocyte Contractility and Electrophysiology
Responding to the need for more predictive preclinical assays for cardiac liability, ACEA Biosciences introduced a "ground-breaking" device the company describes as "next generation." Designated the xCELLigence RTCA CardioECR System, it is…
Advanced Analytics Improve Biopharma Operations
Archived Webinar: QbD Development of a Purity Method Using UPLC and Mass Detection
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Three Big Risks in 3D Printing Pharmaceuticals
Are the risks of leveraging this new technology outweighing the benefits for drug makers?
Since 3D printing emerged, the technology has been used to create everything from construction materials and automobile parts to cheeseburgers and sneakers.3D printing has enormous potential across industries, and one of the most transformative applications has been in the medical field. The technology has been used to create prosthetic limbs, body tissue, dental restorations and more. In fact, as of December 2015 the FDA had cleared more than 85 3D-printed medical devices.But one of the latest medical applications – 3D printed pharmaceuticals – has called into question whether the risks of leveraging this new technology outweigh the benefits for drug makers.Manufacturing pharmaceuticals has been part of the 3D printing discussion for…
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New formats and formulations will change CMC requirements
In the already diverse field of biopharmaceuticals, chemistry manufacturing and control (CMC) is about to get more complex. New formats and formulations will change CMC requirements, dictated by the need to characterize products of increased complexity and the expectation of authorities that companies will keep pace with the latest technologies so as to minimize quality risks.The potential implied changes required for an effective CMC include: more extensive information handoffs, greater cross-functional cooperation and a greater focus on relationships with regulatory agencies. These trends will demand a rethinking of the CMC setup and an appraisal of its capabilities based on a company's product pipeline.Overarching…
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At the product level, pharmaceutical companies are constant innovators, perpetually unveiling new and more powerful treatments for a growing range of ailments. When it comes to manufacturing, however, drugmakers are notorious for lagging other industries. (Just last year, The Wall Street Journal described pharmaceutical manufacturing processes as "dating to the days of the steam engine.")
More specifically, pharmaceutical manufacturers have not been able to realize the benefits of Product Lifecycle Management (PLM) technology, unlike their counterparts in the discrete manufacturing world. There, PLM is a technology-enabled discipline that has connected every step in the product lifecycle, enabling radical improvements in product…
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In order for biopharma companies to move quickly and adaptively enough, an outstanding project management process is critical
The global biopharmaceutical market is expected to grow at a compound annual growth rate (CAGR) of 9.4% from 2014 to 2020, reaching $278 billion in revenue by the end of this six-year period. Growth is being driven by numerous factors: such as aging populations in most of the Western world and an increased prevalence of chronic disease. However, likely the most important contributor to growth is biopharmaceutical drugs' superior effectiveness in treating many disease states, including treating conditions for which there were previously few effective drug treatment options available.
Given the growth of the biopharmaceutical segment, and biopharmaceuticals' ability to more precisely treat many disease states, the industry needs to…
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Validation, calibration and qualification are extremely critical in pharmaceutical processes. Understanding them is necessary in order to meet cGMP guidelines.
Pharmaceutical facilities consist of various processes, each of which must be accurate to ensure that the end product is of high quality. While validation is concerned mainly with processes, it is referred to as a qualification when the same approach is applied to a machine or equipment instead of a process.
Why is Validation Needed?Validation is a systematic approach where it is confirmed that any process in a pharmaceutical facility will operate within the specified parameters whenever required. This is achieved by collecting and analyzing data. Validation is done to assure that the processes will produce consistent and repeatable results within the predetermined specifications.
Validation is needed as it verifies whether the quality…
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Last month I walked the show floor at Pharma EXPO, executing my usual tradeshow-technology-trend spotting. It was difficult to advance more than 10 feet without hearing or reading the world "serialization." I'm fairly certain serialization could have had its own hall at McCormick Place.
And perhaps the attention is warranted given the timing. The November 2017 DSCSA compliance deadline, after all, is a federally mandated requirement. The DSCSA will require all prescription drugs in the U.S. to have unique serial numbers to enable track and trace. This marks the first time that many pharma manufacturers and supply chain partners will have to implement serialization and manage serialized product inventory, though many are ahead of the…
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FDA has 700+ Vacant Drug Approval Jobs
The U.S. FDA, under fire for its drug approval backlog, says it has over 700 job vacanies at CDER.
The U.S. FDA, under fire for its drug approval backlog, says it has over 700 job vacanies at its Center for Drug Evaluation and Research (CDER).
At a recent industry event, Janet Woodcock said that the agency is struggling to hire and retain staff because pharmaceutical companies are offering employees much higher salaries.
CDER had 711 openings out of 5,525 positions at the end of September, said an FDA spokewoman.
Aside from salary, the speed in which the agency goes through the hiring process is a challenge. "A young person with a family can't wait four months for us to get through some of the federal hiring process. So if they have something else that's more . . . expedient, they will take that," said Peter Marks,…
Identifying Contaminants in Pharmaceutical Manufacture
Specifying Instruments to Meet Pharmaceutical Hygienic Requirements
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BRIEF: How Humidity and Temperature Mapping Differ
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Management's Role in Sustaining Continued Process Verification
The Changing Biopharma Risk Equation
Multinational survey of pharma execs offers insight on pharmaceutical companies' growth strategies and risk management in the challenging biologics landscape
As pharma companies expand, they are looking more and more to biologics for their next potential blockbusters. However, this class of product — ranging from well-established large molecule drugs to truly novel therapies — poses major challenges because of its scientific complexity and sophisticated development requirements.Furthermore, expanding the drug pipeline isn't the only growth strategy most companies are pursuing. They are also planning to expand geographically and expect to face various risks doing so, including unfamiliar regulatory environments, shifts in pricing and changes in customers' ability to pay.
All this means that risk management is rising in pharma executives' agendas. To manage risks, companies are…
Cold Chain Planning: An Integrated Approach
Saving Money at the Loading Dock
Establishing a Root Cause Failure Analysis Program at a Pharma Facility
Corrective actions are implemented to reduce future failures, but resources aren't allocated to identify the root cause on a significant failure; This gap creates the opportunity to implement a RCFA program.
Your clean steam generator system stops and alarms. Production halts; operations quickly calls maintenance. Maintenance jumps into action and determines that the bearing seized in the feed water pump. A bearing order is expedited through procurement, maintenance efficiently makes the repair the next morning, and the production team runs tests before putting the system back into operation. Corrective actions are created to ensure that the bearing is stocked in the MRO storeroom, and to double frequency of the pump's preventive maintenance. The senior leadership team is satisfied with the response and corrective actions, and praises the team for limiting the production delay to just 24 hours.
Does this scenario sound familiar? A critical…
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Every cleanroom requires a carefully controlled environment maintained with Good Manufacturing Practices to prevent contamination
In 2012, a fungal meningitis outbreak in the United States was traced to a compounding pharmacy in the Northeast. The pharmacy distributed contaminated vials to medical facilities in 23 states. These were administered to more than 14,000 patients before anyone linked symptoms to the tainted medication.
By the time the source was isolated and the drug recalled, 48 people had died and 720 required treatment for persistent fungal infections. Investigators later discovered both procedural shortcuts and significant failures in cleaning and maintenance at the pharmacy.
This is not an isolated instance of inadequate cleanroom sanitation. The FDA maintains a well-populated list of inspections and citations conducted between 2006 and 2012 on its…
VS-050 Six Axis Aseptic Robot
Risky Business: High Potency Products
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Pharma execs and facility managers are constantly exploring all possible ways to tighten their belts and bolster the company's bottom line. A growing number are finding one path to savings runs through an often-overlooked area of their facility's operations – its loading docks.
Pharmaceutical manufacturing is a highly competitive business, with product development, quality control, regulatory/compliance and even shareholder issues that are much more complex than in many other industries. Because of that, pharma execs and facility managers are constantly exploring all possible ways to tighten their belts and bolster the company's bottom line. A growing number are finding one path to savings runs through an often-overlooked area of their facility's operations – its loading docks.
When trailers are positioned at the dock being loaded or unloaded, gaps often exist between the trailer and the edges of the dock opening, through which expensive heating and cooling energy can escape, and unwanted contaminants…
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Delta DSV Steam Trap
Controlling Emissions the BAT Way
Hyderabad-based API provider Neuland Labs sheds the stigma of Indian manufacturers by building stringent quality control into every process
Neuland Lab's core business and operational expertise for more than 30 years has been the manufacturing of Active Pharmaceutical Ingredients (APIs) for the generic market as well as APIs for custom manufacturing. During that time, Neuland has become a reliable source in the pharmaceutical industry, boasting more than 400 DMFs worldwide, with 45 of those filed with the U.S. FDA.
One of the very first Indian contract manufacturers to be inspected by the U.S. FDA, back in 1997, Neuland now has two U.S. FDA- and EU GMP-compliant manufacturing facilities — one in Bonthapally and one in Pashamylaram (45,000m² and 38,000m², respectively), as well as a state-of-the-art R&D facility, with the collective ability to produce more than 75…
Regeneron Boasts Huge Expansion Plans for NY Facility
ISPE Names AstraZeneca China Facility of the Year Winner
Sustainability lobby group Changing Markets has published a report that reveals the presence of lethal drug-resistant bacteria in water found near multiple production sites in India.
Sustainability lobby group Changing Markets has published a report that reveals the presence of lethal drug-resistant bacteria in water found near multiple production sites in India.
According to the report, analysis of water samples found high levels of drug-resistant bacteria at sites in three Indian cities: Hyderabad, New Delhi and Chennai.
Out of 34 sites tested, 16 were found to be harboring bacteria resistant to antibiotics. At four of the sites, resistance to three major classes of antibiotics was detected, including last resort antibiotics -- those used to treat infections that fail to respond to all other medicines.
The report called out Hyderabad-based Aurobindo Pharma as one of the worst offenders, saying the drugmaker is "a…
FDA, CDC Link Outbreak to PharmaTech's Water System
Speedy Delivery
CMO Almac to Add 310 Jobs in Pennsylvania
The new jobs will be in the sciences, clinical services and clinical technologies and pharmaceutical services
Ireland-based Almac Group, a CMO with U.S. headquarters in Souderton, Pennsylvania, announced it will invest $24.4 million to expand its Montgomery County, Pa., site and add 312 full-time jobs over the next three years. The company plans to expand its existing 240,000-square-foot Souderton facility and lease an additional 26,000 square feet in office space in nearby Lansdale.
The new jobs will be in the sciences, clinical services and clinical technologies and pharmaceutical services, the company said. They also plan to retain 1,110 current employees currently working there.
The Pennsylvania Department of Community and Economic Development offered funding that included a $1.56 million "first program" grant for new machine lines, computer…
Stop Feeding Customers Cardboard Pizza
Managing Regulatory Inspections: A CDMO Perspective
Recipharm Expands CDMO Biz with India's Kemwell
The Rise of Biosimilars
North America and Europe will dominate the global biosimilars market as demand rises for these products
Like a phoenix, biosimilars rose from pharma's ashes to revitalize an industry faced with the loss of patent exclusivity for several biologics. Now this global market is expected to reach $2 billion by 2018.1
While there are currently only four agents approved in the United States, more than 20 are approved in Europe.1 Development is accelerating, and according to some estimates, there are 56 biosimilar products in the pipeline, with 30 companies having active programs.1 In fact, according to the 2016 Nice Insight CMDO Outsourcing Survey, 50 percent of respondents are currently engaged in developing biosimilars.2
Biosimilars represent a significant opportunity for healthcare systems to deal with the rising cost of medications and access…
Pros and Cons of Biosimilars
FDA Warns of Impulse-control Problems With Mental Health Drug
Teva Pharma Says Allergan Generics Deal Delayed
Merck Demands Gilead Pay $3B-Plus in Hep C Royalties
Teva's Rimsa Plant Halted Production, Laid Off Workers
Novartis May Be Looking to Buy Amneal Generics
Manufacturing Costs Will Be Critical to Biosimilars' Success
Mylan to Shutter Meda's U.S. Headquarters
Just months after its $7.2B acquisition of Meda, Mylan is closing the company's U.S. headquarters in Somerset, NJ.
Just months after its $7.2B acquisition of Meda, Mylan is closing the company's U.S. headquarters in Somerset, NJ.
The closing, effective December 31 2016, will result in 94 layoffs.
Last February, Mylan agreed to buy Sweden's Meda AB for $7.2 billion in cash and stock -- a price that represented a 92% premium -- and investors were not pleased. A large part of Mylan's attraction to the Meda deal involved acquiring Meda's European EpiPen sales, as well as its over-the-counter business. Meda turned down two previous buyout offers from Mylan in 2014. The acquisition of Meda also provides Mylan with entry into a number of new and attractive emerging markets.
Read the NJ.com release
Perrigo to Acquire U.S. Consumer Goods Distributor
Sun Pharma Expands OTC Biz with Dermatology
Sun Pharma Launches First OTC Drug
J&J Ordered to Pay $72M in Lawsuit Linking Powder to Woman's Cancer


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Stephan Schick sworn in as judge
December 28, 2012 —
At a gathering of members of the Sullivan County legal profession, along with politicians, business people and assorted movers and shakers, Stephan Schick, who served as the executive director of Sullivan County Legal Aid and was a legals aid attorney for nearly 30 years, was sworn in as a New York State Supreme Court Justice for the Third Judicial District, which serves Sullivan County as well as Ulster, Green, Albany, Schoharie, Rensselaer and Columbia.
Schick was praised by several people including former District Attorney Stephen Lungen, who, in his nearly 30-year career as the county's top prosecutor, very frequently was an opponent when Schick was in the courtroom defending a suspect who could not afford an attorney. Lungen praised Schick as a committed attorney who gave his clients vigorous and professional representation even when those clients did not appreciate it.
At the ceremony in Monticello on December 28, Schick accepted the judgeship in honor of all of the legal aid professionals working in Sullivan and beyond, knowing that they are often not appreciated by society. He also got a laugh at the expense of his former judicial sparring partner, Lungen.
There will be a longer article about this event in The River Reporter newspaper later this week.


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The Lady of the House and I were on the road for our October vacation.
We had visited family in Socorro. Our next stop was Tombstone, Ariz.; where Wyatt Earp and Doc Holliday once walked, a sun-blasted desert burg that boasts that it is "The Town Too Tough to Die."
"Just three hours away," I said.
"Practically a hop, skip and a jump," said The Lady of the House.
"We'll take our time in the morning," said The Lady of the House. "We'll have some breakfast, do a little shopping, then off to Tombstone. I'll be soaking in that hotel hot tub before you can say, 'Jack Robinson.'"
After a casual morning in Socorro we hit the highway.
"Tombstone here we come," proclaimed The Lady of the House.
An hour down the interstate I realized I had made a mistake. A quick jaunt of three hours would instead be a six-hour, sun-drenched journey.
The Lady of the House was not amused.
I decided I'd entertain her with what I knew of the area.
"Look," I said pointing out the window. "See those three hills? They call those 'The Three Sisters.'"
"Yes," said The Lady of the House. "I see the bumps."
More asphalt, yucca and mesquite rolled by.
"Look," I said. "Animas Peak. And Animas once had the winningest 6-man football team in the state."
"Yes," said The Lady of the House. "I see that bump, too."
Then we rolled into Arizona.
"Look," I said pointing out the windshield, still trying to cheer her up. "That peak is called 'Dos Cabezas.' It means 'two heads' in Spanish.
"More bumps on a hill," said The Lady of the House.
Finally the rhythm of the interstate and baked terrain won out and she dozed off.
About an hour later we pulled into Tombstone and stopped at the hotel.
"We're here," I said, gently waking The Lady of the House.
"Jack Robinson," she said. "Now where's my hot tub?"
Grant McGee is a long-time broadcaster and former truck driver who rides bicycles and likes to talk about his many adventures on the road of life. Contact him at: email@example.com.


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Buffalo, NY 14203
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We have answers to the most commonly asked questions.
Find your topic by the first letter.
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- Latent autoimmune diabetes in adults (LADA): What is it?
- Latisse: The answer for longer, thicker eyelashes?
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- Game Details
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- Videos (3)
- Images
- Cheats & Walkthroughs (45)
The Biggest Loser Ultimate Workout Videos
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Gatorade's Games That Make You Sweat
Kristin Adams tries out 3 current workout games on the market: The Biggest Loser Ultimate Workout, Your Shape Fitness Evolved, and finally with the help of UFC fighter Urijah Faber, UFC Personal...
X-Play Investigates: Can Videogames Help You Lose Weight?
Motion-control consoles tout fitness games to take your body to the next level, but are they the real deal? Watch Sara Underwood, Blair Herter, and trainer Blake Baietti test out The Biggest...
The Biggest Loser Ultimate Workout Kinect Offical Trailer
Get fit with your friends and family while using the Kinect. The Biggest Loser Ultimate Workout official trailer shows you how facial recognition technology works with the fitness game. Go get your...
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Juan Fernández fur seal
The Juan Fernández fur seal (Arctocephalus philippii) breeds on the Juan Fernández Islands off the coast of Chile. It is the second-smallest of the otariid seal (the closely related Galápagos fur seal is smaller still). Discovered by navigator Juan Fernández in the 16th century, the seals became a target for sealers in the Maritime Fur Trade era. They were thought extinct in the mid-20th century until a population of 200 was found. The population was protected and has grown quickly. There are now believed to be at least 10,000 animals on and around the island.
The seals have a relatively robust body and a long, slender and pointed snout. They have stubby foreflippers and hindflippers, and a mane of long, coarse guard hairs from the top of the head to the shoulders. Adult males are dark brown to black, but the guard hairs can have yellow or tan tips. The males also have a more bulbous nose than the females and juveniles, as well as being longer than the adult females. The adult females have an overall brown colour, but the tips of the guard hairs may fade to yellow or tan. The females are less robust at the chest, neck and shoulders than the adult males. Pups are born black, but become lighter during the first few years.
- ^ Aurioles, D. & Trillmich, F. (2008). Arctocephalus philippii. In: IUCN 2008. IUCN Red List of Threatened Species. Retrieved 30 January 2009.
- Randall R. Reeves, Brent S. Stewart, Phillip J. Clapham and James A. Powell (2002). National Audubon Society Guide to Marine Mammals of the World. Alfred A. Knopf, Inc. ISBN 0375411410.


text: 0 Perilous Voyage by Max Nimos Best Sellers Trending Art Best Selling Paintings Best Selling Abstract Art Prints Best Selling Photography Best Selling Posters Popular Subjects Animals Architecture Childrens Art Floral & Still Life Landscape Maps Military & War Music Science Fiction & Fantasy Skylines Spiritual Transportation Featured Artists Brickhut Cozamia Eric Joyner Erin Ashley James Niehues Jennifer Lommers Jonas Gerard Marcia Baldwin Mark Lawrence Michael Creese Michael Tompsett Collections ArtLoversOnline Design Pics The Fine Art Masters Panoramic Images Retro Images Archive StockTrek Images WorldWide Archive Create Your Own Photo Canvas Custom Frame Photos Perilous Voyage by Max Nimos (2007) Sign inCustomer Service Cart Houzz Share on Tumblr Tweet +Add to Cart Available Sizes inches / cm Petite $57.50 Small $69.00 Medium $86.25 Large $115.00 Grande $230.00 Massive $345.00 » component prices Print Frame Mats Glazing Fitting Customize Framing or choose Canvas Print Customize Canvas or choose Framed Art Print Click to save as artist's preferred kit Paper Enhanced MattePremium Photo GlossyPremium Photo LusterUltraSmooth Fine ArtHahnemuhle Photo Rag 308Hahnemuhle Fine Art PearlHahnemuhle Torchon Mounted? ★★★☆☆ Details Paper print only, too large to frame online. Frames Choose a color » ø Top Mat | Middle Mat | Bottom Mat ø Glazing Style Soft EdgeWhite EdgeBlack EdgeImage WrapUnstretched 1½ inches thick (3.75 cm) Product Details Artist grade canvas, archival inks, wooden stretcher bars, and UVB protective coating Availablity Usually ships within five business days. Artist Max NimosCollection artDescription Brave explorers trying to cross the arctic ocean. Popular Configurations Stretched Canvas Modern Lines Contemporary White Classical Baroque Unframed print Explore More from the same collection View All Max Nimos's Recent Work About the artist Max Nimos, USA Member Since December 2007 Artist Statement "I've always had a desire to take images from my mind's eye and bring them to reality." Max V. Nimos started drawing the day he was introduced to a pencil. Later he began dabbling in watercolor and eventually migrated to acrylic on canvas. In his adult life he worked as an engineer and photographer, but is now primarily a digital artist with one foot in the science fiction genre and the other in wherever his imagination takes him. He has been featured in "The best of Renderosity 2003" DVD and won first prize in a 2004 Renderosity 3D holiday art contest. His artwork has also appeared on several book covers and webzines. He presently lives in the United States. Community Comments Catalog Details Product No 605199 Subjects Beach and Ocean, Boats and Ships, Landscape, Transportation Style Fine Art Medium Tags arctic, ice, iceberg, max, nimos, sailing, sea, ship Create Frame Photos Photos on Canvas Sell Sell Art Online Become an Affiliate Get a Trade Account Common Questions Company Info About Us Contact Customer Comments Return Policy Social Tumblr Pinterest Twitter Facebook Instagram Our Wall Art Family CanvasOnDemand | Photo Canvases GreatBigCanvas | Decorate Huge Terms of Service Privacy Policy Copyright © 2016


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iHerb Customer Reviews
Savings of: $0.82 (9% off)
Try it, you'll love it!
Posted by eathealthy on Jun 29, 2013
Wild rice is a delicious side dish to any meal, and can also be used in salads. This rice is high in protein and B vitamins and is harvested in North America. It has a nice chewy texture that anyone can appreciate over the gummy texture of white or brown rice. It does take a little longer to cook but is worth the wait. Worth every penny! If you like my review check out my page by clicking eathealthy in blue above to see reviews of all the products I have purchased from iHerb!
Posted by Reviewer1283167 on Jul 31, 2012
This is an incredibly fragrant and tasty rice, nothing like regular brown rice at all. It tastes delicious and contains a more complete protein source than normal rice. I love that it's harvested by Native Americans using traditional methods! You should deffinetely try this rice.
Haven't tried it yet
Posted by Reviewer1284478 on Feb 18, 2015
Haven't tried it yet
Items 1-3 of 3 total


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Offering an antique, framed lithograph from my aunt's estate. This is a magnificent, hand colored lithograph taken from St. George Mivart's; A Monograph of the Lories or Brush Tongued Parrots. That book was published in London 1896 by R.H. Porter, and it contained 61 hand-colored plates by John Gerrard Keulemans. Only 250 copies of the book were ever produced.
This lithograph was taken from one of those books. Directly underneath the colored picture it reads; 1) The Chattering Lory - Lorius Garrulus - 2) The Yellow Backed Lory - Lorius Flavo - Palliatus - Published by R. H. Porter. On the top left hand corner is written; The Loriidae. On the top right hand corner is written; Plate XXIV. Under the lowest branch the plate is numbered 3/4 and to its left it is signed in pencil JGK, the initials of the artist.
The frame is wood, painted black and delicately edged in gold. It measures 17" X 20 1/2" and is 1" deep. The lithograph is matted and under glass and the visible portion of the colored plate is 9 1/4" X 11 1/2".
This stunning piece has no damage other than that the edges of the paper of the litho are somewhat yellowed with age. No tears, foxing or stains. Beautifully framed and ready to hang.
This hung in my aunt's home next to another matching Mivart lithograph of the Purple Bellied Lory, taken from the same book. That piece is listed separately.
Shipping and insurance and included in the price.
Antiques - Jewelry - Collectibles - The Odd. The Interesting. The Beautiful.
Unique Jewelry. Beautiful Porcelain. Interesting Collectibles. Rare Books. Textile.


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Visnezade Mah. Acisu Sok. NO. 19 Macka
Besiktas Istanbul
+90 212 326 1100
+90 212 326 1122
▪ firstname.lastname@example.com
Local time:
Maps & Directions
Swissotel The Bosphorus, Istanbul has spacious rooms that are designed to cater to the needs of guests requiring the highest level of service and privacy.
Swissotel The Bosphorus, Istanbul offering 63 luxury suites, from studios to three-bedroom suites, so you can experience Istanbul like a local.
Swissotel The Bosphorus, Istanbul is right in the centre of Istanbul on the banks of the Bosphorus.
This 4000 m² oasis offers holistic spa treatments from all over the world.
Our Guest Services is pleased to assist with your every need.
Pürovel makes a very enticing offer to those who want more frequent and regular treatments: Pürovel Spa Treatment Royalty Card. You can prolong "the spa effect" in your life with this card which offers a 25% discount for any Pürovel treatment of your choice and a 20% discount for Pürovel's efficient face and body products. A new era awaits you where you will feel much better with our new loyalty card available for both members and non-members.
For detailed information: +90 (212) 326 2990 or firstname.lastname@example.com
+1 506 388 6948 (Toll Number)
BOOK SMART, STAY SMARTERAll reservations on Swissotel.com enjoy a room upgrade* and late checkout*. *Subject to availability upon arrival. Limited time offer.


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The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
Love you too!
Your email has been sent!
Decorating a home is no small feat, but you've always been fearless in the face of an new flat! Outfit your space with the ease of a superhero with this epic collection of posters, which celebrates the 75th Anniversary of DC Comics and its classic cover art. Rescued from their archives and accompanied by commentary from comics guru Robert Schnakenberg, each 11x14 poster in this 100-print collection gives your den or studio a much-needed punch of pop culture. Whether you admire Superman, Batman, Wonder Woman, and the rest of DC Comics crew on your coffee table or let the framed images soar above that bookshelf of prized titles, your decor is bound to be bursting with character!
Final Sale: This item cannot be returned or exchanged.
Sorry this item isn't available anymore


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Weekly Review: Tablets
Wammy Desire 2 Up for Pre-Order in india
WickedLeak known for their tablets has launched the Wammy Desire 2 in the 7-inch budget tablet category. Strangely, the tablet comes in two Android variants: the now out-dated Ice Cream Sandwich (ICS) and the latest Android 4.2 Jelly Bean variant. the tablet comes with a 7-inch IPS display with 1280 x 800 pixel resolution. The screen supports multi-touch up to 5 fingers. Under the hood runs Samsung's Exynos quad-core processor. Wammy Desire 2 comes with 8-GB internal memory (expandable up to 32 GB ) and 1 GB RAM. Wammy Desire 2 comes with a 2 MP rear end camera and a basic front camera for video-calling. Priced at Rs 9999 the tablet sounds like a good buy for budget-conscious buyers.


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Dental Crowns and Teeth Whitening
16 of 248
Was this photo helpful? {{ voteCount + ' other' + (voteCountOthers == 1 ? '' : 's') }} found this helpful
Old dental crowns tend to look like dental work. By replacing them we can create a result that looks as if no dental work has been done. The results can be invisible. In addition, the teeth whitening makes the smile look even younger.
By uploading this photo, Scott Greenhalgh, DDS has agreed with RealSelf.com policy that they've secured proper patient consent.


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you are here
down to see...
of the benefits and advantages of using horses
Training Courses
Details of group training courses and Level II accreditation
Logging Equipment
A wide and increasing range of award winning horse logging and horse work equipment
Cleft and sawn timber, firewood and timber structures
Appearances at shows and working demonstrations including BHL, BHLCT and BFotWH events
Links Page
General links above
links to my seven top sites
Glyndwr comes from a distinguished line of Silesian Norikers bred for horse logging by Josef Svoboda in the Czech Republic and introduced to the UK by Doug in 2012.
He was born here in May 2013 and is currently being expertly trained - for horse logging and carriage driving - by 'old boy' Jack Everett from near Ross on Wye.
Glyndwr is of superb conformation, with a calm and grounded temperament and is looking for a skilled new owner who can give him a worthwhile working future.
Please contact Gudrun Leitz for more information, or just for a
chat: firstname.lastname@example.com
Tel: 0044 1531 640125 Mob: 0044 7530 622708
Glyndwr in September 2015
Doug was involved with the British Horse Loggers from its original formation
in the early 1990s, and became Chair of the BHL Committee in 2000, when
BHL was a specialist group within the Forestry Contracting Association.
Doug then led the BHL on a period of rapid change and development.
Under his leadership, the BHL separated from the FCA, and was established
as an independent group. Shortly afterwards, Doug's practical example
and advocacy brought to the BHL the patronage of HRH The Prince of Wales.
Royal patronage opened doors for a small organisation. The British Horse
Loggers Charitable Trust was formed with Doug as Chair, and this allowed
the creation and funding of the British Horse Loggers Apprenticeship Scheme.
Doug was always hospitable, and saw social gatherings as a very necessary
cement for a small organisation with a membership spread widely and thinly
across the UK and beyond. His woodland, Childer Wood in Herefordshire,
was the venue for the annual BHL AGM and Competitions over many years,
together with other courses and events.
He was a tireless and fluent advocate of horse logging, running demonstrations,
talks and training courses, encouraging and inspiring many new entrants
to take up the reins. Doug's networking skills were phenomenal,
both by e-mail and face to face. He travelled widely in the UK and Europe,
especially in support of FECTU, and had visited horse loggers as far away
as Japan.
In more recent times, Doug's interests diversified from his horse
logging core to a wider view of the modern working draught horse on the
land and on the streets. His personal enterprise, the British Festival
of the Working Horse, has promoted demonstrations of modern economic horse
power in market gardens, vineyards, and elsewhere.
For those of us who knew him, we are left with the memory of a big, genial,
generous, hospitable and, above all, passionate man. He is going to be
a very hard act to follow. The finest memorial we can give him is to continue
the cause of which he was so eloquent a champion.
tributes to his horses, Dot,
Diamond & Ella
can be read by clicking on their names.
For more information about Doug Joiner
Doug was
a professional horse-logger and qualified trainer, based at Childer Wood
and Meephill Coppice in Herefordshire and working for National and Local
bodies, Wildlife Trusts, and woodland owners. He was an Approved Contractor
being on the Professional Register of the British Horse Loggers, the National
Industry Body for horse logging contractors. He had several working horses.
He also provided tuition and ran demonstrations of working horses at shows.


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Dispatches from Montreal Jazz Fest: Bela Fleck, Eric Bibb, Jake Shimabukuro and more
July 4, 2011. Posted by David Tallacksen.Add new comment | Filed under: FIJM 2011
Bela Fleck stopped by to share some great stories.
Ukelele wizard Jake Shimabukuro brought along his instrument:
And a video of his performance:
Acoustic blues singer Eric Bibb stopped by for a great discussion:
China Moses - not just a great talent but also daughter of DeeDee Bridgewater - dropped by.
And local vibraphonist Jean Vanasse rode his bike to the Festival Mediatheque, what a great talent Montreal has!
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Interest Level
Grades 3 - 7
Reading Level
Grade level Equivalent: 4.5
Lexile® Measure: 740L
Guided Reading: T
- Adventure
- Comedy and Humor
- Cleverness
- Dogs
- Loyalty
- Friends and Friendship
About This Book
Showoff: someone who is given to bragging, having a swelled head, boasting, swaggering, knowing it all . . .
In this engaging, laugh-packed read, Griffin Bing and the Swindle gang are back in action, and things are really going to the dogs!
Griffin has never been a huge fan of Savannah's vicious Doberman, Luthor. Still, he thinks it's unusual when Luthor goes crazy at a mall dog show and injures a champion beagle. And he doesn't think it's fair that the beagle's owner is suing Savannah's parents, who insist on sending Luthor to the pound. So Griffin comes up with a plan to earn enough money to settle the lawsuit. All he and his friends have to do is spring Luthor from the pound, bring a legendary dog handler out of retirement, and train the Doberman to win at the big national dog show. How hard can it be?
Gordon Korman has been making readers laugh out loud ever since he published his first book, This Can't Be Happening at Macdonald Hall, at the age of 14. His many fans are sure to love his funny, crowd-pleasing novels about Griffin Bing and his misfit pals.
Items Added to Cart:
1 Paperback
2 Hardcover
1 Teacher's Edition
$48.99 Subtotal


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You may have heard of cranberry juice's potential benefits' namely that it can help support the urinary tract. This is largely due to d-Mannose. d-Mannose is a naturally occurring simple sugar related to glucose that is contained in cranberries' as well as other fruits such as pineapples.
The body only metabolizes a small portion of d-mannose intake; the rest is excreted through urine. When d-mannose is flushed out during urination' it helps maintain the mucosal surface in the urinary tract by supporting a healthy environment where it can thrive. The mucus membrane promotes comfort in the urinary tract' while working to prevent bacteria such as E. coli (Escherichia coli' not the infamous food poisoning-related kind) from sticking to its walls (which could lead to infection). E. coli bacteria don't belong in the urinary tract' so it's essential to get rid of them before they multiply. Fortunately' despite their ability to stick to human cells' E. coli cells prefer to bind with d-Mannose if at all possible; therefore' they attach to its molecules and are then expelled the next time you go to the bathroom.
D-Mannose Powder provides nourishment to the good bacterial flora in order to support balanced amounts. This may help you avoid urinary tract infections (UTIs)' which can be painful and inconvenient. This powdered supplement may also support liver and bladder health. The d-Mannose in this powder is sourced from birch and beech wood.
Take one scoop (one-half teaspoon) three times daily' either with or between meals. Mix the powder with water. Every container of Pure Encapsulations' D-Mannose Powder contains 100 grams.
Pure Encapsulations seeks to formulate and manufacture high-quality' hypoallergenic dietary supplements. Quality control during the formulation and manufacturing process is paramount. All Pure Encapsulations products are made with the most bioavailable ingredients possible.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose' treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Scoop (1/2 Teaspoon)
Servings Per Container: 111
Amount Per Serving / % DV
D-Mannose 0.9g / *
*Daily Value not established.
Sourced and manufactured to avoid: Artificial additives' allergens' GMOs' environmental contaminants' added excipients.
As a dietary supplement' take 1 scoop' 3 times daily' mixed with water' with or between meals.
Tamper resistant. Use only if safety seal is intact. If pregnant' consult your physician before taking this or any other product. Keep out of the reach of children. Store sealed in a cool' dry area.
Allergy / Dietary Needs
- Allergen Free
- Artificial Additive Free
- GMO Free
- Hypoallergenic
- Environmental Contaminants Free
- No Added Excipients
Ratings & ReviewsReview This Item
Overall Rating for D-Mannose Powder - 100 Grams
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By Betty
from So CAL
Works good
D-Mannose Powder by Pure Encapsulations works nicely. It's not like a regular water pill.
√ I would recommend this item to a friend.
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If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.


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Knee Rehabilitation
All You Need to Know About Knee Rehabilitation
Chronic ache or sudden injury, when experiencing pain in the area knee rehabilitation in needed – and welcome. How you go about the treatment will likely depend on what type of injury or pain was incurred.
Runners often experience knee pain, partly due to the strain placed on the area while jogging or running. If a runner experiences a sudden, sharp pain it may be due to an injury such as a torn ligament. Such a thing requires an equally sudden response. See a doctor or visit the emergency room right away.
Other times the act of regular running, especially on pavement or hilly courses, will put strain on the area and eventually the need for knee rehabilitation arises. Treatment for this can begin at home before there is need to see a medical professional. Rest is the first step, as taking strain off of your knee is important. Apply ice to the area as well, being sure to do so in short intervals so as not to risk damaging your skin from the cold. Afterwards, wrap your knee in bandage – not too tightly – for compression of the area. Lastly, elevate the knee while you are resting, keeping it propped on a stool or pillows for comfort. Rest, Ice, Compression and Elevation – or RICE for easy reference.
This type of knee rehabilitation may not be extensive enough, especially with sudden injuries. If that is your case, or if these home treatments aren't offering relief, see your doctor. A visit to a physician who specializes in sports medicine will likely be required (mainly orthopedic surgeons). It may be that surgery is the best option, but be sure to gather all of the information and discuss your case extensively with the specialist before making any decisions. Surgery will require lengthy knee rehabilitation.
With chronic pain (or post surgery) you may be referred to a physical therapist. The therapist will often check your stance or stride (if possible) to determine whether you are applying undue strain to the knee. They should provide you with strengthening and stretching exercises that serve to help the knee recover and improve blood flow to the area. Regular and sometimes frequent visits to the physical therapist are necessary, as is a commitment to follow through on the exercises.
You may benefit from a visit to the podiatrist, who can fit you with orthotics that will correct any difficulties with your stride or stance. Sometimes the simple act of walking or standing a certain way has the potential to harm your knees. Orthotics can offer support and correction where necessary.
Medication can be taken while you are progressing through knee rehabilitation. Anti-inflammatory medication works well as it reduces pressure and swelling in the area. Be sure to talk to your doctor and obtain advice about what type of pharmaceutical is best for you. Watch that your medication doesn't mask or disguise the actual rehabilitation of your knee. Work through your physical therapy exercises without them whenever possible.
There are many things you can do to prevent knee injuries and knee strain from happening. If you are overweight and experience pain in the knee joints losing a few pounds will help to reduce strain and pain. Stretching and warming up before exercise can help to improve blood flow and loosen muscles. Also remember to always wear protective gear when engaging in contact sports – leg braces or knee and shin guards can help you to avoid knee injury altogether. Talk to your podiatrist about the ideal shoes for your chosen sport and wear any orthotics prescribed to you. An ounce of prevention can save hours and even days in therapy.
Knee rehabilitation is generally not a quick process and requires commitment on your part. But the ability to participate in your favorite sport or just move around without pain is well worth it.


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from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A condition of the foot resembling frostbite, caused by prolonged exposure to cold and dampness and often affecting soldiers in trenches.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A medical condition which can affect the feet when they are constantly cold and wet. Similar to, but not the same as frostbite.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. resembling frostbite but without freezing; resulting from exposure to cold and wet
From its occurrence among soldiers in trenches.(American Heritage® Dictionary of the English Language, Fourth Edition)
Sorry, no example sentences found.


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Hollowtech two, long distance bikepacking? (:
Bike Forum
Which bottom bracket?
Easy. Hope stainless steel. Not expensive at all when you consider just how long they last. Lots of pretty colours too!
I've been doing some reading about this recently and so I predict people will recommend (In order of best to worst):
Chris King,
Interestingly also ordered price high-low as well. I've just bough a groupset with a Gusset BB.
Thanks for the reccomendations! Hope does look fantastic but I'm on an incredibly tight budget. Be worth buying one used? Or should I go Gusset?
Gusset ext24 for me- good life, though not quite as good as Hope... But more servicable as they use a standard bearing rather than a specific, so easy to find and you can choose your quality. If they cost the same as a Hope that might not be such a simple decision but they cost pretty much the same as a set of Hope replacement bearings...
I can't recommend it myself as I haven't got it yet, but on other threads on here people have rated the Gusset ones pretty highly.
The main selling point for me was that the bearings are standard so cheaply replaced unlike the Hope ones.
For the price I'd say it's worth a punt, don't think you can get a Hope one second hand for the same money.
Brill, thanks for the advice guys, I'll go with the Gusset, the ability to replace it with standard bearings is exactly what I want
Does anyone know which bearings it uses, i.e, the size?
Topic Closed
This topic has been closed to new replies.


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This post was written for Making the World Cuter by Kassi Mortensen, our crafty friend of Truly LovelyBack to school means lots of activities, dates to remember, things to schedule in… I wanted one central place I could write down events coming up during the month so I scoured the stores for a dry erase calendar to put on my fridge…What I found was that none of the stores had one big enough that was also magnetic… So… I do what all good crafters do in that situation… 😉 I made my own!Here's how you can make your own Magnetic Fridge Calendar in three easy steps!
1. Materials needed: Large dry erase calendar, a packet of magnetic strips (found in the craft dept. of most stores), some super glue or heavy duty craft glue2. Attach your magnetic strips to the back of the calendar. The strips I used were sticky backed, but I wanted to make sure they were really stuck on there, so I dabbed some super glue on as well.3. Hang it on your fridge!That's it! Super easy, inexpensive and exactly what I needed to keep track of the month ahead!Happy crafting friends!!!! And happy back to school! 😉
Now It's Your Turn!How do you keep organized during the school year? Share your tips in the comments!
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Watch out for neighbors in today's society
What is immoral in today's world?
In my lifetime our society has become as rats fighting to get the last scraps of garbage. Simple things like children having enough respect to speak respectfully to elders, stand and offer their seat when an elder walks into the room, leave the room when elders are talking about adult matters. This respect used to carry over to seniority on the job. New hires giving their position to someone with more seniority. I am not saying that any one senior gets everything they want because some do not keep their end of the unspoken contract with gratitude and gentility. These failures are the fault of us the parents, who raised these now so called adults who now run the workplace as it is. Today's workplace now sees workers with great records and years of service and experience being discharged so replacement workers can be hired part time at lower costs. Workers being hired in such numbers, some get only two hours of work a week. It might be alright for some countries, but this is the United States. At first it was union busting by managers, now it's just plain employee busting. Managers may think it's OK to malice your employees over employment but the rest of us are watching. There is a home healthcare provider in this town using just such tactics, and a fast food establishment doing the same. However the word is out, and I will never use either again. I am urging others to do the same. We must take care of our neighbors, because soon things will change, and these companies will be left in the cold.
Duane Alderman
Mineral Wells, W.Va.


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Are you planning a trip to Qatar or the UAE? You can now save time and apply for your tourist visa online.
Some nationalities are eligible for a Qatar tourist visa on arrival, click here to learn more.
Transiting through Doha on your flight with Qatar Airways? Make the most of your stop by exploring the city's attractions and culture or by spending time with family and friends.
You can now enjoy the new Transit Visa when you add a short transit or stopover between 5 and 96 hours in Doha to your itinerary without any additional fare charges.
Fill out and submit the form below for the latest information on visa and passport requirements for your Qatar Airways flight.
Remember that visa requirements can change with little or no notice. It is your sole responsibility to ensure you have the correct visa and meet the local medical requirements. Qatar Airways accepts no liability for your failure to do so.


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For Assistance510-444-CITYTTY 238-3254
|The following forms and informational sheets are available by clinking on the links below.
For form submittal, print out the form in question, fill it out using legible print or type, and submit it in person, by fax (510) 238-6739, by email, or send it to the Fire Prevention Bureau at the address above. Be sure to direct it to the attention of the relevant staff person or Fire Prevention Unit.
|Administration Forms
|OFD Fire Report Request Form
|Public Records Request
|Annual CUPA Permit Certification Form
|Request for File Review
|Fire Alarm Plan Submittal Requirements
|Haz Mat Facility Fire Code Permit Form
|Fire Code Permit Application
|Smoke Detector Service Certification
|False Alarm Billing Appeal Form
|Hazardous Materials/CUPA Forms
|Certification of Return to Compliance for CUPA Violations
|Hazardous Materials Storage Facility Closure Form
|Hazardous Materials Business Plan
|Aboveground Storage Tank Install
|Underground Storage Tank - Permit Application Coversheet
|Underground Storage Tank - New Install or Modification Permit
|Underground Storage Tank - Repair/Removal Permit
|Underground Storage Tank - Fees
|Fire Code Forms
|Care Facility Classifications
|Emergency Procedure Plan - Guide
|High Rise Evacuation Floor Plan Requirements
|Building Evacuation Floor Plan Requirements
|Hood Training Certification
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|Fire Hydrant Application Form
|R-1 Maintenance Requirements


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October 2004
Angles of Repose
ECM Records
Whether you love the way saxophonist Joe Maneri messes with pitch, or think he sounds like an old Lee Konitz vinyl LP left out in the sun too long, you have to admit: He's got his own thing going. Although I've most often leaned toward the Konitz-in-the-sun theory, Angles of Repose (ECM) has me reconsidering. Perhaps it's the context; my admittedly limited exposure to Maneri has been mostly via recordings with drummers and bass players-in other words, with him as the horn player in a more-or-less typical free-jazz group. Angles teams Joe with fiddle-playing son Mat (on viola here) and bassist Barre Phillips. When playing with a bassist and drummer, it seems like Joe tries trying to fit his square-peg-of-a-woodwind style into the round hole of conventional jazz instrumentation. In contrast, this format is tailor made for him. Without a drummer to obscure his lines or push him in directions he doesn't want to go, Maneri is able to use time and space as freely as he wants.
The best of these improvised cuts leave plenty of room for the musicians to explore the nuances of pitch and timbre that define Joe's-and to a lesser extent Mat's-concept. Instead of the solid-body electric instruments Mat often favors, here he plays a conventional viola, probably because there's no drummer and he doesn't have to fight to be heard-whatever the reason, it's a good thing. Phillips plays like an honorary Maneri; his approach meshes perfectly with father and son. Beautiful, fresh, involving music. Sometimes context is everything.


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Andy Kunasek was unanimously appointed to the Board of Supervisors in September of 1997. Kunasek was subsequently elected by the constituency of District Three in 1998 and re-elected in 2000, 2004, 2008 and 2012. He's served as chairman of this five-member board five times.
Kunasek's first and foremost concern is fiscal accountability and responsible government. Under his leadership, Maricopa County has earned a national reputation for sound management and accountability. Kunasek has sponsored policies to ensure that Maricopa County carries no general obligation debt, making this large county one of the few of any size with no debt. Maricopa County uses a pay-as-you-go philosophy when constructing capital infrastructure like buildings, saving taxpayers hundreds of millions in interest charges.
Kunasek has also prioritized justice and law enforcement during his tenure, having approved more than $2 billion in public safety improvements including jails and Sheriff's patrol equipment, establishing new courts, and making Justice and Superior Courts more accessible and efficient.
In 2003, Kunasek was named "Outstanding Elected Official of the Year" by the National Association for County Parks & Recreation for his championing of the County's parks system. Thousands of acres of open space and parks were added to the Maricopa County Parks system under his leadership. Kunasek is currently working to connect all the county parks though the creation of a continuous 242 mile trail system that encompasses the entire Valley.
Kunasek remains active in his community having served as treasurer of the Maricopa County Republican Party, a member of the Maricopa County Trial Court Selection Committee, Maricopa County Charter Committee, and the Maricopa County Citizens Judicial Advisory Council. He was also selected as a delegate to the Republican National Convention in 1996.
Supervisor Kunasek serves on the NACo Defined Contribution and Retirement Advisory Committee and is past president of the Arizona County Supervisors Association. He serves on the Greater Phoenix Convention & Visitor's Bureau, MAG Economic Development Committee, Great Hearts Academies and Maricopa County Board of Health.
Kunasek owns interests in plant nursery and other agricultural oriented enterprises, and is president of Mercado Management, a diversified land acquisition and real estate management company. Supervisor Kunasek is an Arizona native and is a graduate of Mountain View High School in Mesa, Arizona. He earned a bachelor's degree in management from Arizona State University.
Kunasek, his wife Kim, and their three children live in the North Valley.


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On this page
How It WorksIn PreparationService LocationAppointments
Nuclear Medicine
Benefits of Nuclear Medicine
Nuclear medicine procedures are used to both diagnose and treat a variety of diseases and conditions. Common diagnoses include:
State-of-the-art nuclear medicine tools are effective in diagnosing, staging, and treating many types of cancers.
How It Works
Nuclear medicine scanning involves administering small amounts of radioactive material called tracers. These tracers are injected, inhaled, or swallowed by the patient before or during the scanning procedure.
Patients lie on a table while the nuclear medicine camera moves over or around them for about 30 to 60 minutes. (Complex scans may take longer and be repeated over several days.) The camera records the pattern of the tracers as they travel through the body or to various organs. Images are shown digitally on computer monitors and then interpreted by radiologists who send reports to your referring health care provider.
In Preparation
The radioactive tracers do not cause any side effects or sensations and leave the body quickly. Most nuclear medicine procedures require minimal preparation. You may be told to restrict your eating or drinking or to discontinue certain medications for a short period of time. You will receive specific instructions when your exam is scheduled.
When nuclear medicine is being used to treat such diseases as hyperthyroidism, cancer of the thyroid, or for relief of bone pain caused by cancer tumors, patients receive larger amounts of radioactive material. In these cases, the radioactivity stays in the body for a longer period of time in order for the therapy to be successful.
All BCH technologists are registered and licensed through a national credentialing organization.Service LocationNuclear medicine is provided at Foothills Hospital.Appointment SchedulingIf your physician orders a nuclear medicine procedure, first call the BCH's Nuclear Medicine Department directly at 303-415-7546 between 8 a.m. and 4:30 p.m. weekdays to schedule an appointment.
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Inside Imaging
Take the Patient Experience SurveyBCH Imaging Overview
Bone Density ScanningBroomfield Imaging Center
CT ScanDiagnostic Imaging ⁄ Fluoroscopy
Healing Tendonitis
Imaging Physicians
Interventional Radiology
Stereotactic Breast BiopsyVaricose Vein Treatment


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Boinc and Zooniverse
BOINC is a platform for volunteer computing and grid computing. At a first glance, it looks dated and unappealing but, after some digging, one finds himself really engaged with the myriad of research projects that are using the system. As a novice user, I felt a great admiration for the people who built the platform, but unfortunately that didn't encourage me to download the software and contribute, given that my computer is already too full of junk.
In my opinion, there's a lot of drawbacks in being such a centralized, huge platform. The projects end up looking too similar, and, since all the contribution is passive, it's harder to get engaged. It ends up looking like a very niche space.
Some projects, like FoldIt or GPUGrid certainly did their marketing better, and look more modern and appealing, but the overall experience could be greatly improved by spending some money in a redesign of the websites, interface and general information architecture. The existing community around the projects is amazing and should probably be the frontline of BOINC.
Zooniverse is the total opposite. It was created in 2007 and, I don't know if they had this website and system from the beginning, but they obviously did their homework to reach a more mainstream audience.
We just have to compare their two taglines: Open-source software for volunteer computing and grid computing (BOINC) vs. Real Science Online (Zooniverse).
Or the first menu that appears on the site: Volunteer – Download · Help · Documentation · Add-ons · Links vs. Take part in Science Projects, Experiment in the Laboratory
They are based on quite different ideas or needs, so it's not perfectly fair to compare them, but it's fair to say that Zooniverse is more attractive for most of the people. It's web based, the projects require active participation, but they mostly have some kind of gamification, and there's a certain humanitarian aspect in each of them.
On my first visit, I found myself quickly joining Moon Zoo and identifying moon craters, which turned to be harder than I expected. I really liked that, despite being a modern website, the registration process was so simple that it didn't even require a confirmation email. It was a proof of confidence towards their users that I really appreciated. The only thing that I missed, and this applies also to BOINC, was an up-to-date status of the project. I somehow needed to know how was the project progressing, if it was finished or just started… and couldn't find it clear enough.


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Dental Plaque Remover
Scaling and Planing – Thorough Cleansing Dental Processes
Scaling and planing are thorough cleansing dental processes that are designed to stave off cavities and cure conditions related to gingivitis.
The substance that causes cavities, plaque, solidifies and becomes tarter. Tarter aggravates the gums and destroys the teeth, which will eventually fall out. Scaling is an effective procedure to eliminate tartar through the use of a dental tool that is specially made to scrape away tarter. Scaling thoroughly cleanses the teeth near and under the gum line, which cannot be accomplished by everyday dental hygiene procedures such as flossing and brushing.
Once the tarter is scraped away, the next procedure is planing, which basically sands down any rough edges so that the gums and teeth are able to better guard against plaque. After only a short time, the gums will return to their healthy form, and be nice and pink.
You should talk to your dentist or dental hygienist if you have some concerns regarding the scaling and planing procedures. It's possible that one of a number of dental techniques, such as sedation, can be administered to ease your mind. A lot of patients want to be sedated when they are being scaled or planed. The best dentists are going to go to great lengths to make sure you are completely at ease.
Root sealing and planing are techniques that are necessary to prepare teeth for periodontal therapy. These processes are vital to periodontal therapy, which cannot be performed without the planing and scaling having been completed. Scaling gets rid of any plaque, stains, calculus or any other substances that have adhered to the teeth. An ultrasonic dental tool is used to perform root planing. This gets rid of calculus, plaque, and root surface endotoxins. The process is also intended to get rid of cementum, and it is done on roots of teeth that indicate a loss of bone and receding tissue. The procedure provides a deep cleaning to the teeth that have the presence of harmful bacteria. Such a technique could possibly halt the spread of periodontal disease, if the harm that is already done is minimal. There is a dental clinic in New Jersey that is comprised of experts who possess the knowledge, abilities, and tools to effectively scale and plane your teeth.
They use ultrasonic scaling with a universal tip to get rid of teeth gross accretions by gently accessing all areas. Once scaling is complete, another dental tool takes a look at the root to catch any calculus or other substances that might have been missed. These procedures are fierce, but they work, and there's no doubt that the money you spend will be worth it.