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Town of Arlington: the official web site where you can connect with all of the Town's agencies and commissions. click here: http://www.town.arlington.ma.us/Public_Documents/index
LivableStreets Alliance: a Boston/Cambridge based advocacy group to promotes sustainable transportation and a more-holistic view of transportation planning that balances the needs of pedestrians, cyclists and transit riders with motorists. click here: LivableStreets Alliance
MassBike: a state-wide advocacy organization that promotes bike safety, education and infrastructure. click here: www.massbike.org
Walk Boston: New England's premiere pedestrian advocacy organization whose primary focus is Boston but has also worked on pedestrian-related improvements in our area, including along the Mystic River and Alewife Brook. click here: www.walkboston.org
Walking in Arlington: our own local version of Walk Boston, they promote pedestrian improvements and host historic walking tours. click here: www.walkinginarlington.org
Transportation Advisory Committee: a volunteer-based committee appointed by the Selectman to guide transportation-related policy, planning and infrastructure projects. click here: www.arlingtontac.com
Arlington Bicycle Advisory Committee: a volunteer-based committee appointed by the Selectman to guide bicyle-related policy, planning and infrastructure projects. click here: www.abac.arlington.ma.us
Sustainable Arlington: a town committee dedicated to acting on a local level to achieve climate stabilization and reducing our community's carbon footprint. click here: http://www.sustainablearlington.org/sa15/home
Green Streets Initiative: a grassroots organization of people from Cambridge and surrounding towns and cities, who celebrate, promote, and advocate for the use of alternative transportation. click here: www.gogreenstreets.org
Traffic Calming: an issue that we here at the EALS Coalition hope to tackle very soon, this web site is one of the better ones that presents simple examples of different techniques to slow traffic on residential streets. click here: http://www.trafficcalming.org/index.html
The Capitol Square: our local neighborhood business group. Support our neighborhood businesses by shopping locally. http://thecapitolsquare.com/blog/


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North Central faculty volunteer to improve student safety in public school district
Two North Central College faculty members are working to improve safety for students and staff at Rosa L. Parks Middle School in the West Harvey-Dixmoor School District 147 in Harvey, Ill., south of Chicago. They are Renard Jackson, assistant professor of education, and Keith Avery, lecturer in psychology.
By providing a free bullying and school climate assessment, Jackson and Avery hope to help students who are currently being bullied and suffering in silence. School Superintendent Dr. Alex Boyd, in conjunction with the District 147 school board, welcomed the assessment, which took place Dec. 6. Providing some visibility and resolution to bullying and school climate issues will help a student or school struggling with bullying.
Also, in the near future, Jackson and Avery will begin capturing detailed information from all students about what bullying might be taking place, what they see happening in their environment and how they feel about the educational environment. In addition, teachers' perspectives will be captured and the data will be analyzed. Within days, the school/district leadership will have reports/data allowing them to take action that addresses their specific student needs and school climate issues. The process will also reveal places where the school is succeeding in its efforts to provide a safe learning environment for children.
"We are happy to assist because educational leaders at this district want to know about bullying and school climate issues, which is not necessarily true at all schools and districts," says Jackson.
Avery, licensed clinical psychologist in private practice in Naperville as well as lecturer in psychology at North Central College, says, "We recommend that this type of student safety tracking be made available to all students and schools, and we invite parents and educators to support this process. We can do much better and this tool can help identify how and where we can reduce bullying and improve the learning environment for kids."
In addition, Avery has been working with school administrators in other school districts, making assessment of students, staff and faculty regarding bullying behavior, school climate issues, and Social and Emotional Learning (SEL) as required by Illinois State Law Public Act 93-0495. The law requires schools to assess and track SEL development and implement a program as part of their regular curriculum, just as they do with math, reading and other state learning standards.
Avery has developed the SEL School to help administrators and teachers be compliant with state standards and have a comprehensive bullying prevention program. It involves needs assessment, consultation, curriculum advice and tracking. Bullying and school climate issues can be traced back to unattained SEL objectives.


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Insight Home | Next Article
Issue 1, 2013
Partner HighlightMulti-Gigahertz FPGA Signal Processing
How can an FPGA clocked at 500 MHz support gigasample per second data throughput rates? Chris Eddington, senior product and technical marketing manager in the FPGA and Systems Group at Synopsys and Baijayanta Ray, corporate application engineer for the Synphony Model Compiler product at Synopsys, explain how design teams can quickly and easily create parallel architectures to enable multi-gigahertz signal processing applications on FPGA devices. The data reproduced in this article was first published in Xilinx's Xcell Journal.
The growth of wireless communications continues to put pressure on the wireless spectrum. As a result, there is an increasing need for bandwidth monitoring, and ultra-fast conversion from the time domain plays a significant role in enabling high-speed signal processing. Consequently, design teams are seeking faster ways to implement the core building block used in gigahertz-speed signal processing: the fast fourier transform (FFT).
One way to speed up FFT processing is to use more parallelism in the hardware architectures. In fact, this approach is essential where the gap between the highest possible clock rates in an advanced FPGA might be several hundred megahertz, yet the target data sample rates for modern monitoring applications are measured in gigasamples per second (GS/s). The use of wideband ADCs and state-of-the-art FPGAs, such as Xilinx's Virtex®-7, enable design teams to exploit megahertz chip clock frequencies and reach gigasample data rates.
Communications protocols are becoming increasingly packetized, resulting in decreasing signal duty cycles. This requires a dramatic decrease in scan repeat time, which is only possible with low-latency FFT cores. This is another reason to use parallel FFTs; the latency scales down almost proportionally to the ratio of sample rate to clock speed.
Parallel FFT Architecture ChoicesThe Radix2 Multi-Path Delay Commutator kernel (Radix2-MDC) is one approach to FFT implementation, which is highly suited to creating scalable, parallel architectures, especially for FPGA devices.
Figure 1a shows an FFT implementation based on the Radix2-MDC approach for an FFT of length 16, which exploits two parallel data streams and uses pipelining to ensure that there is the correct "distance" between the multi-path delay of each data element.
Figure 1a: Radix2-MDC kernel (Radix2 Multi-Path Delay Commutator)Figure 1b: Using Radix2-MDC modularity to create parallel FFT architectures
Design teams can implement parallel variants of the architecture by increasing the width of the datapath and vector operations (Figure 1b).
The complex multiply operation is fundamental to FFT implementation, and how this is performed also affects the scalability of the architecture. Common choices include the 4multiply (4M) and 3multiply (3M) structures. For the lowest area, designers choose the 3M complex multiply, but for the best performance, 4M is the preferred choice. However, designers should also consider the target FPGA's available DSP structures before making a final decision, as these may affect how efficiently different microarchitectures map to the final hardware.
An alternative to the multi-path delay approach for FFT implementation is the single-path delay feedback (SDF) FFT. While it's easier to perform flow control and dynamic length reconfiguration with MDC structures, implementing flow control (stall) signal incorporation in an SDF structure typically leads to a significant reduction in maximum throughput.
Concurrent TradeoffsFFT cores are available off the shelf, but these typically consist of "streaming" or "block" architectures capable of processing a maximum of one sample per clock. This constraint limits throughput to the maximum FPGA clock speed, which is insufficient for the sampling rates demanded by modern monitoring applications.
A parallel FFT architecture accepts multiple samples per clock and processes them concurrently to deliver multiple output samples per clock (Figure 2). While throughput increases, the penalty is increased area.
Figure 2: Parallel FFT architectures process multiple samples at a time to achieve greater throughput than the target device clock frequency
Table 1 below shows tradeoffs for a typical Virtex-7 FPGA design. The data shows that as parallel throughput increases, multiplier (area) utilization increases with a slightly lower multiple (better than linear). Slower system clocks and timing closure yield sub-linear throughput growth as parallelism increases; on modern FPGAs, this degradation is getting smaller. Overall, it's possible to achieve better-than-linear throughput/area growth. Finally, latency decreases as parallelism increases.
Table 1: Typical performance and area tradeoffs for parallel FFTs on Virtex-7 class devices
Note that the specific numbers in Table 1 are only valid for a given target and configuration of the FFT, which, in this case, is length = 1024, 16-bit input, dynamic length programmability (4-1024), and flow control. Flow control is very important for applications such as spectral monitoring, where side channel information is often utilized to change the FFT size and hence the resolution bandwidth, or to temporarily stall the FFT while other operations, such as acquisition, are going on. Theoretically, the design team can implement flow control by inserting buffers before the transform operation. In practice, for acquisition-driven operations like spectral monitoring, it is difficult to estimate the size of the buffer required, which results in the use of large, fast, and expensive memory banks.
Case Study: A 1024-length Parallel FFT for Virtex-7 and Virtex-5 FPGAsWe used Synopsys' Synphony Model Compiler (MC), a model-based high-level synthesis tool, to demonstrate how parallel FFT architectures can map to commercially available FPGA devices. We chose to explore a set of parallel FFT results for Xilinx Virtex-7 and Virtex-5 FPGAs, using the configuration shown in Table 2.
Table 2: Case study FFT configuration parameters
Synphony MC's library includes a parallel FFT IP block, which design engineers can use to target advanced FPGA devices like Virtex-7. The FFT is a custom IP block, which uses arithmetic primitives to create an architecture based on user-specified options such as length, precision, flow control, and dynamic programmability.
The vector support and custom block methodology in Synphony MC allowed us to create a concise, parameterizable parallel Radix2-MDC block. We used this block to instantiate parallel FFTs using different configurations, such as the subset of a 1024x16 parallel FFT datapath using the 'PR2MDC' custom blocks shown in Figure 3.
The PR2MDC blocks incorporate I/O that consists of a length 32 vector, which represents 16 complex samples of real and imaginary values, and a length and twiddle factor address parameter. Although the fixed-point word length grows by one bit at each stage, it is easy to adjust this by using the block's parameters. Each block implements the parallel Radix2-MDC function (Figure 1b) using Synphony MC arithmetic operators such as add, shift and multiply. Designers can use Synphony MC to target specific microarchitectures available on their selected FPGA device. For this design, we chose a 4M complex multiply, which maps to the Xilinx DSP48E block using 18x25 multiply mode.
The block is designed to daisy chain the twiddle factor lookup for performance and flow control capability. The Synphony MC parallel FFT core shows no significant timing degradation between turning flow control on or off or using dynamic length programmability, which makes the throughput scalability it offers on advanced FPGA devices a useful feature when building real-time spectral monitoring applications.
Figure 3: The Synphony Model Compiler Parallel FFT IP block user interface and the resulting micro-architecture
We used Synphony MC to generate RTL optimized for Virtex-5 and Virtex-7 targets and Synopsys Synplify Pro with Xilinx ISE 14.2 for place and route. Table 3 shows the area and timing results following place and route. The actual scalability matches our theoretical predictions and the FPGA family capabilities. We achieved over 7 GS/s data throughput using a 16x parallel configuration with only approximately 6.3x the resources. The better-than-linear area growth is due to multiply operations that become fixed-coefficient as parallelism increases, which implement more efficiently in logic rather than using a full multiply in a DSP unit. This applies predominantly to the last K-point FFT (Table 3).
Table 3: Parallel FFT results on Virtex7 485T: -3 and Virtex5 SX95T: -2
SummaryHigh-throughput gigasample/s applications, such as spectral monitoring, require parallel FFT architectures in order to achieve high throughput rates with devices that use megahertz clock rates. The case study presented here shows that a parallel FFT design using the Radix2-MDC architecture can effectively achieve over 7 gigahertz throughput on FPGA devices in a 16x parallel configuration.
We developed the parallel FFT designs in a high-level design flow using Synphony Model Compiler. This enabled us to fine-tune the implementation for DSP hardware mapping across different Xilinx devices. Using Synphony MC, it was possible to explore the eight architectures characterised in Table 3 in less than a day.
For ASIC design, Synphony MC integrates with the Synopsys low power implementation flow. For more information, read the article Power-Performance Tradeoffs for Signal Processing Architectures.
About the AuthorsChris Eddington is Sr. Technical Marketing Manager for High-Level Synthesis at Synopsys and has over 20 years of experience in ASIC and FPGA design. He has held various roles in technical marketing, algorithm development and IC design at semiconductor companies that develop video and audio conferencing ICs and wireless communications systems. He holds an MS engineering degree from the University of Southern California and an undergraduate degree in Physics and Math from Principia College.
Baijayanta Ray is a corporate application engineer for the Synphony Model Compiler product at Synopsys. He received his PhD in wireless communication from Indian Institute of Technology, Kharagpur in 2010. Prior to Synopsys, he worked at National Instruments as part of the team that developed Signal Intelligence solutions.
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Rockford.edu / Academics / Departments / Political Science / Secondary Teacher Certification
Students interested in political science for the purpose of becoming secondary school teachers should consult the catalog section on the Social Sciences divisional major.
Refer to the Education Department for further information.
View more information about Secondary Certification in the Academic Catalog.
Copyright © 2016 Rockford University, all rights reserved


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ASHCROFT Genealogy in All Regions
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8. Elroy Christenson's Family Records
9. Bouse, La Paz County, Arizona: Bouse Cemetery
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Tralucent Audio 1Plus2
"*Please ignore the audio quality / comfort / design / isolation / value sliders for this review. As far as I can tell, they seem broken* This is a universal in-ear monitor with a two balanced armature drivers and a dynamic driver. This earphone costs $1250 IEM with a cable that costs about $800, or as a package together, about $1400. I'm part of an Australian listening tour for this..." --a_recording
KEF M200 Hi-Fi In-Ear Headphones, Aluminum/Black
" I purchased these earphones a couple of weeks ago and have had the urge to write a review. However, I needed too make sure that they were fully "burned" and used in different environments to see how they performed before taking the plunge. This is my first ever headphone review, so please bear with me - I can't say that I know all the right terms or generate scientific diagrams and..." --mcook1970
Tralucent Audio Ref 1
"Tralucent Audio Reference 1 – With Comparisons I would first like to give a huge thanks to Head-Fi member, warrior1975 for loaning me his Ref. 1 and TWau cable for review. I was interested in hearing what the hub-bub was all about regarding the Ref. 1. I was interested further because most people who have heard it either love the..." --moedawg140
Tralucent Audio 1Plus2.2
" Introduction: Let me start by saying this isn't really a full fledged review but a testimonial to the brand Tralucent Audio and especially massive thanks to the owner known on Head-fi as spkrs01 or Gavin. My journey with Tralucent began several years ago in 2012, a member I know..." --H20Fidelity


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Perry Watts
Say hello to my Grandpa. His name is Perry Watts and today (2 March) is his birthday. He would have turned 128 years old. Instead, he died of colorectal cancer at age 75 when I was 4 years old. As young as I was, I remember my Grandpa as a sweet old man.
This being National Colorectal Cancer Awareness Month I think it fitting to remember his birthday on the Chris4Life site. And in keeping with our "love your butt" awareness campaign, I don't doubt my Grandpa loved his. After all, he hauled it, shall we say, with him from Tennessee to Canada to California to Omaha, to mention just a few places he called home throughout his adventurous life.
However, loving your butt and being able to do something about it can be two different things. I can only assume he didn't have the healthcare we have today for nipping it, shall we say, before the cancer got too far. We, on the other hand, do. I've had my colonoscopy. I mean, I love my butt and I plan on hauling it a lot further down the road before I shake my Grandpa's hand, again. Love your butt. Haul it in to get scoped out.
Happy birthday, Grandpa.
Are you at Risk For Colorectal Cancer?
- 2nd leading cause of cancer deaths for men and women combined
- Colonoscopies not only discover cancer, but can also stop cancer
- 50% of Americans still do not get colonoscopy reimbursement
- Colon cancer research is still vastly under-funded


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News Postings
Call for Papers - EUSAAT / Linz 2012
- Type: News
- Published: 2012-03-28
- Read source
Abstracts are currently being accepted for poster and oral presentations during the 2012 EUSAAT/Linz conference. Topics to be covered include:
21st century non-animal tools for basic and biomedical research (e. g. humane disease pathways, specific disease models, transgenic animals, xenotransplantation, teratoma assays to prove pluripotency of stem cells)
Implementing of the Directive 2010/63/EU on the protection of animal used for scientific purposes (incl. position of the EU Commission, of EU member states and of animal welfare organisations, examples for the implementation)
Progress in 3Rs research: EU FP6 & FP7 projects on alternatives and member state research funding. (e. g. status national and EU: Research topic overview and future funding policy)
7th amendment of EU Cosmetics Directive: Cosmetics and animal testing - an end in sight (e. g. skin regulatory acceptance, eye regualtory accaptance, sensitisation, skin models and open source)
Chemicals: REACH and animal welfare (e. g. report on use of alternatives, views of companies, animal welfare, methods, search engines)
3Rs progress in other sectors (e. g. vaccine testing, replacing mouse bioassays)
Inhalation toxicology & toxicology of nanomaterials
3R goes 3D! Implementation of 3D methods in toxicity testing
GCCP - Good cell culture practice
Ethical and & legal issues
*Free communications
To submit your lecture or your poster please use the ONLINE SUBMISSION FORM! The deadline for the submission of lectures is April 30th and the deadline for the submission of posters is May 31st.


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Walt Handelsman by Walt Handelsman
- January 31, 2013
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I am uneasy about kids declaring their orientation before puberty. How can they even tell who turns them on?
I have friends who say they knew even when they were very young. Us straight ones had crushes on the opposite sex, the gay ones had their crushes on the same sex. It is hard wired into the brain, whatever anyone says.
I knew when I was 3 years old.
Actually the BSA haven't accepted homosexuals. They've just condoned having any troop refuse to accept gays.
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via Plans Emerge for First Ithaca Mosque | The Cornell Daily Sun.
After almost 30 years of planning and fundraising, Ithaca's Islamic community has raised enough money to build the first mosque in the area — something it hopes to see happen within the next three months.
"We've been trying to raise money for the mosque since the 1980s," said Ahmed Ahmed, a senior research associate in the College of Veterinary Medicine.
Ahmed said that the Muslim population in Ithaca and at Cornell consists of approximately 400 people. Fundraising within the small community — which he said is made up of "mostly students" — to build a mosque was difficult, he said.
Now, with funds in place, Ahmed said that community members have decided to purchase a small building or piece of land, perhaps near The Shops at Ithaca Mall, to establish their mosque.
"If you start even with a small building, you can go to the [big mosques] in big cities and ask them for donations to increase the space. If we don't have a project, they won't give us anything," Ahmed said. "This is the aim — to start anything [so that] at least we can start with something."
A mosque would not only provide a permanent place for prayers but it would also provide spaces for learning about Islam, according to Ahmed.
Aka dawah to infidels.
Ahmed also said that few locations are able to accomodate the mosque's parking demands, adding that he thinks the site would have to provide at least 15 parking spaces for its visitors.
15 parking spaces for a community of 400 Muslims? See the previous post on how mosques get approved even when they don't meeting zoning laws.
Filed under: Alerts, Creeping Sharia, Immigration, Media, Mosque, New York, News, Politics, Religion, Sharia, Zoning Jihad Tagged: | Creeping Sharia, islam, Life, Media, Muslim, New York, Politics, Religion, Sharia, travel


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REC announces another wafer shutdown29. November 2011 | Industry & Suppliers, Markets & Trends | By: Becky Stuart
REC has announced the temporary closure of part of its 650 megawatt (MW) multicrystalline wafer facility in Herøya, Norway, effective from December 1. Around 200 employees are expected to be affected.
Just one month after taking the decision to permanently close three of its oldest photovoltaic production plants in Norway, due to the challenging market conditions presented by 2011, REC says it has decided to "initiate a process with the trade unions" in order to temporarily stop 60 percent of the production capacity in Herøya. The shutdown is expected to last into the first quarter of 2012.
The Norwegian manufacturer went on to say that since October 1, market prices for photovoltaic modules have dropped by a further 10 percent, while wafer and polysilicon prices have fallen by 30 and 35 percent, respectively. In a statement released, it said, "In addition to the price pressure, REC is currently experiencing low visibility on sales volumes and inventories are increasing across all product areas. If the solar market is not improving, further adjustments of production levels will be made."
These factors will combine to negatively impact REC's fourth quarter (Q4) financial results. The manufacturer expects REC Silicon to be particularly impacted. A spokesperson for the company told pv magazine that no new annual production targets have been released on the back of today's announcement. However, they did say that Q4 will see a decline in the production of wafers by around 50 MW "or less" from the original 200 MW target.
In terms of its production targets, REC had said at the end of Q3 that it expected to produce around 4,600 MT of polysilicon in Q4 (Q3: 4,557 MT) and around 18,500 MT for the full year 2011; around 200 MW of multi and mono wafers in Q4 (Q3: 205 MW) and around 1,100 MW for the full year; and around 175 MW of modules (Q3: 181 MW) and around 710 MW for the full year.
Despite today's news, CEO Ole Enger remains positive. "With our strong positions in Singapore and the U.S., and with support from all our stakeholders, we are well positioned to benefit from the improved competitiveness of solar energy," he stated, adding, "I am encouraged by our organization's ability to continue to cut costs and develop new technologies."
Wafer production began at Herøya in 2003. According to REC's website most of the production is sold to external customers, and around 350 workers are employed there.
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Check in from 15h / Check out prior to 12h
BlueBay Banus: Find photos, reviews, information, amenities and compare prices for 4 stars hotels in Marbella, Spain.
BlueBay Banus is situated in Marbella and offers a rooftop terrace and free Wi-Fi. It is conveniently located for those wishing to visit the area's popular attractions.
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paytons is straight
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October 31, 2013 BY Sneaker News / 11
November, 2013 is here, which means our run-down of which sneakers are releasing this month is also here. This month is one that will really see the LeBron 11 kick into full gear, starting with the likes of tomorrow's Heat flavored release. After that the "Laney" Jordan 5s looks to dominate the opening weekend, with plenty more Reeboks, New Balances, and more rounding out the month. Continue reading for a full breakdown, including release dates and prices, on the sneakers releasing in November 2013, and make sure to bookmark this page for continued updates on the pairs coming out over the next few weeks.
Updated: November 13th, 2013
Sneakers Releasing 11/01 – 11/03
Nike LeBron 11
Color: Black/Metallic Silver-University Red-Bright Crimson-Dark Grey
Style Code: 616175-001
Release Date: 11/01/13
Price: $200
Nike Air Max 360 Diamond Griff
Color: White/White-Metallic Silver-Apple Green
Style Code: 580398-100
Release Date: 11/01/13
Price: $170
Reebok Q96
Release Date: 11/01/13
Price: $115
Reebok Q96
Release Date: 11/01/13
Price: $115
Reebok Pumpspective Omni
Release Date: 11/01/13
Price: $125
Air Jordan V "Laney"
Color: White/Varsity Maize-Varsity Royal-Black
Style Code: 136027-189
Release Date: 11/02/13
Price: $170
Nike Janoski Digi Floral QS
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paytons is straight
Please update to coincide with the new release information about the Doernbecher Collection
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The toughest is the Lebrons & the Griffey's let's keep it real!
had the laneys for over a month already, waiting for those foamposite
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The Friday night "nickname game" between the Miami Heat and Brooklyn Nets took a turn for the dramatic in the fourth quarter, when LeBron "King" James got into a scuffle following a foul from Mirza "MT3" Teletovic.
James was originally called for an offensive foul for pushing Andrei Kirilenko. Then, as he ran in for a layup, James was wrapped up by Teletovic. James clearly took offense, and a brief scuffle ensued.
According to Andy Vasquez of The Record, Teletovic's reaction to James' histrionics was one of amusement.
So, to recap, Mirza Teletovic laughed in LeBron James' face when LeBron was coming after him. The NBA, where amazing happens.— Andy Vasquez (@andy_vasquez) January 11, 2014
The reaction of Twitter came swiftly and strongly.
Couple things. 1. Michael Beasley holding LeBron back, the voice of reason. 2. AK flopped SO BAD 3. James overreacted.— Hardwood Paroxysm (@HPbasketball) January 11, 2014
Again, LeBron's been on edge all night. That looked like more of a final straw situation.— Ethan J. Skolnick (@EthanJSkolnick) January 11, 2014
You could see that coming. Haven't seen LeBron this hot in a Heat uniform.— Ethan J. Skolnick (@EthanJSkolnick) January 11, 2014
Teletovic was charged with a flagrant foul.


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Oslo Viking Ship Museum Excursion Reviews
A must see attraction the Kon TIki Museum detailing the adventure of Thor Heyerdahl's expedition on a balsawood raft from Peru to Polynesia in 1947. Fortunately, we had shown our kids the Kon Tiki documentary so they knew what they were seeing. It was amazing to see it up close and person.
Our wonderful guide took us first to the viking ship museum. It was very busy, crowded and was a small building. It started raining so many were near the entrance. Amazing to see.
Truly unique-the story of how the ships were found and excavated is as interesting as the artifacts themselves.
We had a very personable and clearly speaking tour guide that narrated our bus ride, and tours of the museums. She answered many questions about life in Sweden and everyone seemed pleased. Our original tour was canceled due to the arrival of some heads of states for meetings before the G-20 summit.
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Anatomy of a tsunami
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You Are Here: Home » News From NINDS » Proceedings »
The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the NIH Office of Rare Diseases (ORD), and the Tourette Syndrome Association (TSA) jointly sponsored a workshop to develop new and improved treatments for children and adults afflicted with Tourette syndrome (TS). The workshop was held on September 10-12, 2006, and included approximately 100 scientists, clinicians, and industry representatives in the fields of basic neurobiology, behavioral sciences, neurogenetics, neuroimaging, neurological disorders, motor disorders, and child psychiatry. The attendees from within and outside the TS field convened with the express purpose of bridging the communication and information gap between basic and clinical science disciplines to evaluate the biological and clinical basis for existing TS treatments and to understand recent updates in the neurobiology of TS in order to define new therapeutic directions.
The meeting began with an overview of the phenomenology of TS and existing treatments. TS is characterized by an enduring pattern of motor and phonic tics that present during childhood. According to current best estimates, TS affects approximately 6 of every 1000 schoolchildren. The severity and frequency of tics peak early during the second decade of life, but then decline considerably in many patients by their late teens and early 20s. Currently, there is no curative pharmacological treatment for TS, but several agents have proven successful at attenuating tics and improving psychosocial functioning. Since TS is associated with improper dopaminergic tone in the brain, atypical neuroleptics (e.g., risperidone) and typical neuroleptics (e.g., haloperidol) that function by blocking dopamine signaling at D2 receptors are commonly prescribed. Other commonly used agents include 2-adrenergic agonists (e.g., clonidine). Botulinum toxin A is increasingly being used to treat severe focal tics. In terms of behavioral approaches for tic control, habit reversal training, which employs competing responses to block tic manifestation, has been shown to be an effective technique in adults and appears to also work in children. A handful of case studies suggest that deep brain stimulation, in which electrodes are implanted into specific brain regions to deliver electrical pulses to prevent tics, is a promising approach for controlling TS, but considerably more study of the technique is needed.
The next portion of the workshop centered around presentations highlighting the brain structures and neural circuitry implicated in TS. Research indicates that TS is very likely caused by abnormal signaling between various circuits in the brain that manifests during development. The chief circuit involves the cerebral cortex, basal ganglia, and thalamocortical regions, with the basal ganglia being a key node in the circuit. Dopamine signaling within the basal ganglia serves to define the salience of information by filtering out "inappropriate" behaviors. Like others, individuals with TS are constantly bombarded with stimuli at the site of the basal ganglia; however, this region of the brain is impaired in its ability to discriminate between salient and nonsalient signals. Importantly, it appears that the ventral striatum is the primary locus of dysfunction within the basal ganglia in TS individuals. Although the cause of basal ganglia dysfunction is not well understood, clues may be found by examining the structure of TS brains. A comparison of postmortem basal ganglia tissue from patients with severe TS and normal controls indicates a below-normal density of inhibitory neurons in the striatum and an above-normal density in the internal segment of the globus pallidus within the basal ganglia.
Additional information about the pathology of TS may be gleaned from studies of related neural processes and/or abnormalities. Striatal neurons and dopamine signaling play a key role in the process of habit formation, particularly habits involving complex and socially relevant behavioral sequences, as is observed in TS patients. Certain areas of neural convergence in the striatum may be particularly sensitive to dopamine modulation during decision-making and habit formation - areas that may be hypersensitive or overactive in TS. Related to habit formation is the biology of addiction, which may parallel the neurobiochemical processes occurring in TS. Individuals with strong tics may have progressed through the process of overlearning such that they become "addicted" to tic behavior as a means to relieve the mounting internal stress or body tension that is often described as characteristic of TS. Addiction studies have revealed that overlearning is associated with heavy dopamine release that activates the prefrontal cortex, which, in turn, releases a surge of glutamate on the nucleus accumbens that then drives drug seeking.
There are no animal models for TS, but syntactic chain grooming in rats is a relevant behavior to study since it is sequential, rule driven, and predictable, yet flexible, much like tics. In addition, studies have shown that the stereotypical movement is regulated by the ventral striatum. Interestingly, D1 agonists dramatically upregulate chain behavior, suggesting that D1 receptor antagonists may suppress this behavior. Because tics are often preceded by premonitory urges, additional insight into the neurobiology of TS and potential therapeutics may be gained by studying prepulse inhibition in rats, which is abrogated by increased dopamine signaling and/or disruption of the ventral striatum.
Pharmacological therapies for TS have traditionally focused on dopamine mechanisms. However, just as different areas of the brain are implicated in TS, so too are different neurotransmitter systems that interact and overlap to contribute to the pathophysiology of TS. Salient interactions include those between dopamine and glutamate, dopamine and serotonin, and dopamine and GABA.
Given the neurobiology underlying TS pathogenesis and the similarities between TS and other neural processes, several attractive pharmacotherapeutic targets for TS emerged during the workshop. These include compounds targeting monoaminergic systems (e.g., D1 receptor antagonists, serotonin agonists or selective serotonin reuptake inhibitors), agents that regulate the prefrontal glutamatergic drive to the nucleus accumbens (e.g., N-acetylcysteine, modafinil), and agents that reinstate GABA receptor function or enhance GABA activity. The application of brain imaging, particularly between sibling pairs, and better identification of the genes involved in TS (e.g., SLITRK1) will facilitate more refined therapeutic approaches.
In order to better poise the TS field to make substantial progress in translating research from the bench to the bedside, several individuals investigating other human disorders presented their experiences with coordinating and accelerating the therapy development process. One particular strategy that may bring TS therapeutics to the clinic relatively quickly and easily is to identify new applications for approved drugs or drugs that went through clinical trials but failed to receive FDA approval. Additionally, the NIH offers several resources to facilitate translational research.
In the concluding discussions, the workshop participants recognized that TS drug development is hampered by two difficulties: (1) there is no animal model of TS for preclinical analysis, and (2) it is difficult to enroll large clinical trials to assess a particular therapeutic. To circumvent these difficulties, it was proposed that a collaborative pilot study group be formed to perform small experimental trials in TS patients in order to cultivate larger trials of appropriate drugs in appropriate patients. The formation of a pilot study consortium would serve to augment the TSA International Genetics Consortium, the TSA Behavioral Sciences Consortium, and the TSA Neuroimaging Consortium already in existence. Participants also expressed that larger clinical trials must be thoughtfully designed to enable researchers to discern which subgroups of TS patients (e.g., based on genetic polymorphisms, functional imaging, the type and severity of tics) derive benefit from a given therapeutic. In addition, some proposed that other measures of improvement, aside from tics, be included in such analyses, such as improvements in quality of life. These ideas have the opportunity to gain further momentum since the TSA is planning another meeting in early 2007 that will focus on pragmatic approaches to clinical trial design and treatment exploration.
Sponsored by the:
National Institutes of Health (NIH): National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), Office of Rare Diseases (ORD)
Tourette Syndrome Association (TSA)
Conference Organizers: Laura Mamounas, Ph.D. (NINDS), Ann Wagner, Ph.D. (NIMH), Giovanna Spinella, M.D. (ORD), Sue Levi-Pearl (TSA)
Science Planning Committee: Chair: Lawrence Scahill, Ph.D., M.S.N.(Yale University); Jonathan Mink, M.D., Ph.D. (University of Rochester), Neal Swerdlow, M.D., Ph.D. (University of California, San Diego), John Walkup, M.D. (Johns Hopkins University School of Medicine), Jorge Juncos, M.D. (Emory University School of Medicine), Peter Hollenbeck, Ph.D. (Purdue University), Harvey Singer, M.D. (Johns Hopkins University School of Medicine), Ann Graybiel, Ph.D. (Massachusetts Institute of Technology), Amy Arnsten, Ph.D. (Yale University), and Eric Nestler, M.D., Ph.D. (University of Texas Southwestern Medical Center)
Tourette Syndrome (TS) is a familial, neurological disorder defined by the childhood onset of chronic motor and vocal tics. The tics of TS most often involve rapid, jerky movements such as blinking, facial movements, head jerking and simple vocalizations such as throat clearing, coughing, grunting and other brief noises. In other cases, however, the tics are more complex involving multiple muscle groups and more complex vocalizations including cursing and repetition of words or phrases. In addition to tics, a high percentage of patients with TS have significant problems with obsessive-compulsive behaviors (OCD) as well as inattention, hyperactivity, and impulsiveness (ADHD) or a combination of these problems. In many cases, these co-occurring conditions when present are more impairing than the tics themselves. Although TS and associated conditions are not life-threatening, the tics can be debilitating, painful and may cause impairment at school or work and social isolation, especially in children. Given the current estimates of prevalence ranging from 0.1 to 1% for TS (up to 6% for transient tics), TS is a significant public health problem.
Most pharmacological treatment trials in TS have focused on tic reduction. Antipsychotic drugs with potent dopamine blockade at D2 receptors are the best-studied and most commonly prescribed class of medications used for tic reduction. Although available evidence indicates that the D2 antagonists are effective for reducing tics, at least in the short-term, these agents are not free of adverse effects, and are often discontinued because of debilitating or dangerous side effects (sedation, dyskinesias, weight gain, cardiac arrhythmias in some people). Another commonly used class of medications is the alpha-2-norepinephrine agonist class. However, the magnitude of effect is typically moderate with this class of drugs, and success with alternative medications has been limited. Preliminary data are available for dopamine agonists and drugs that enhance GABA. However, few drug treatments have been selected in accordance with contemporary understanding of putative TS pathophysiology. Recently, converging information from neuroimaging, neuropathology, psychophysiology, genetics and behavioral neuroscience offer exciting new opportunities for understanding the etiology of TS and for developing optimal treatments for this disorder. In addition to pharmacological therapies, new behavioral approaches suggest novel opportunities for reducing tics and associated disability in people with TS through non-pharmacological means as well as with combined treatments. We hope that a focused dialogue between basic neuroscientists and clinical investigators will guide the identification and selection of candidate treatments for TS in the near term and lead to improved strategies for therapy development in the future.
The overall goal of this conference is to develop improved treatments for children and adults with Tourette syndrome. The conference will bring together clinical investigators, basic and translational scientists representing a range of scientific disciplines from within outside the TS field to evaluate the evidence for existing TS treatments and the latest information on the neurobiology that is relevant to TS in order to identify new treatments. Another goal is to adopt novel strategies for therapy development in TS based on insights gained from translational approaches in other disease areas and from industry. The workshop will conclude with a session on defining future directions in neuroscience and clinical research. The conference hopes to encourage new interdisciplinary collaborations among junior and established investigators in order to guide the identification, development and testing of new treatments for people with TS.
The conference organizers plan to disseminate the discussions and recommendations from this meeting to investigators and clinicians working in the TS field. The published proceedings will aim to identify opportunities and new directions in translational and clinical research in TS.
Introductory Presentations & Overview: Phenomenology of Tourette Syndrome (TS) and Existing Treatments
Basal Ganglia and Tourette Syndrome (Chair: Jonathan Mink, M.D., Ph.D.)
Emerging Directions in TS Research: Translational Implications (Chair: F. Xavier Castellanos, M.D.)
Coordinating and Accelerating the Therapy Development Process: Lessons from other Disorders (Co-chairs: Laura Mamounas, Ph.D. and Ann Wagner, Ph.D.)
Compound Selection: Paths Worth Pursuing (Chair: Harvey Singer, M.D.)
Working Lunch & Brain Storming Session: Given the information that has been shared, where do we go from here?
Roger Albin, M.D.
Department of Neurology
University of Michigan
J. Wayne Aldridge, Ph.D.
Research Associate Professor
Department of Neurology
University of Michigan
Debra J. Babcock, Ph.D., M.D.
Program Director
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Kevin J. Black, M.D.
Associate Professor
Departments of Psychiatry, Neurology, Radiology, and Neurobiology
School of Medicine
Washington University
Linda S. Brady, Ph.D.
Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
National Institutes of Health
Kyle T. Brown
Founder and Chief Executive Officer
Innolyst, Inc.
Cathy L. Budman, M.D.
Movement Disorders Program in Psychiatry
New York University School of Medicine
North Shore Health Systems
F. Xavier Castellanos, M.D.
Institute of Pediatric Neuroscience
Department of Psychiatry
Child Study Center
New York University School of Medicine
Daofen Chen, Ph.D.
Program Director
Systems and Cognitive Neuroscience
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Kathleen Clarence-Smith, M.D., Ph.D.
Chief Executive Officer
Prestwick Pharmaceuticals
Monica Coenraads, M.B.A.
Director of Research
Rett Syndrome Research Foundation
Barbara J. Coffey, M.D., M.S.
Institute for Tourettes and Movement Disorders
Associate Professor, Child Study Center
New York University School of Medicine
Keith A. Coffman, M.D.
Pediatric Scientist Development Program
Division of Pediatric Neurology
Department of Pediatrics
University of Pittsburgh
Children's Hospital of Pittsburgh
Heather M. Cowley, Ph.D.
Medical and Scientific Programs
Tourette Syndrome Association
Joseph T. Coyle, M.D.
Eben S. Draper Professor
Department of Psychiatry and Neuroscience
Harvard Medical School
Mahlon R. Delong, M.D.
Professor and Director of Neuroscience
Department of Neurology
Emory University School of Medicine
Martha B. Denckla, M.D.
Developmental Cognitive Neurology
Professor of Neurology, Kennedy Krieger Institute
Professor of Neurology, Pediatrics, and Psychiatry
Johns Hopkins University School of Medicine
Marian DiFiglia, Ph.D.
Department of Neurology
Massachusetts General Hospital
Harvard Medical School
Celia Dominguez, Ph.D.
Vice President
Department of Chemistry
CHDI, Inc.
Leon S. Dure, M.D.
Department of Pediatrics and Neurology
University of Alabama at Birmingham
Shlomit Ritz Finkelstein, Ph.D.
Graduate Student
Institute of the Liberal Arts
Emory University
Nelson B. Freimer, M.D.
Professor and Director
Center for Neurobehavioral Genetics
University of California, Los Angeles
Kirk A. Frey, M.D., Ph.D.
Department of Radiology and Neurology
University of Michigan
Donald L. Gilbert, M.D., M.S.
Associate Professor
Department of Pediatrics and Neurology
Cincinnati Children's Hospital Medical Center
Anthony A. Grace, Ph.D.
Professor of Neuroscience, Psychiatry, and Psychology
Department of Neuroscience
University of Pittsburgh
Ann M. Graybiel, Ph.D.
Walter A. Rosenblith Professor of Neuroscience
Department of Brain and Cognitive Sciences Investigator
McGovern Institute for Brain Research
Massachusetts Institute of Technology
Dorothy E. Grice, M.D.
Division Director
Child and Adolescent Psychiatry
Department of Psychiatry
New Jersey Medical School
University of Medicine and Dentistry of New Jersey
Katrina Gwinn-Hardy, M.D.
Program Director
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Suzanne N. Haber, Ph.D.
Department of Pharmacology and Physiology
University of Rochester School of Medicine
Jill Heemskerk, Ph.D.
Program Director
Department of Technology Development
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Deborah Hirtz, M.D.
Program Director
Clinical Trials
National Institute of Neurological Disorders and Stroke
National Institutes of Health
David E. Housman, Ph.D.
Ludwig Professor of Biology
Center for Cancer Research
Massachusetts Institute of Technology
Thomas R. Insel, M.D.
National Institute of Mental Health
National Institutes of Health
Samay Jain, M.D.
Assistant Professor of Neurology
Clinical Director of Movement Disorders Division
University of Pittsburgh Medical Center
Scott Janis, Ph.D.
Clinical Research Project Manager
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Joseph Jankovic, M.D.
Professor of Neurology
Department of Neurology
Director, Parkinson's Disease Center and Movement Disorders Clinic
Baylor College of Medicine
Mary E. Jenkins, M.D., F.R.C.P.C.
Assistant Professor
Department of Neurology
London Health Sciences Centre
Jorge L. Juncos, M.D.
Associate Professor of Neurology
Movement Disorders
Department of Neurology
Emory University School of Medicine
Peter W. Kalivas, Ph.D.
Professor and Chair
Department of Neurosciences
Medical University of South Carolina
Robert A. King, M.D.
Department of Child Psychiatry
Child Study Center
Yale University School of Medicine
Becky L. Kinkead, Ph.D.
Assistant Professor
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Roger M. Kurlan, M.D.
Department of Neurology
University of Rochester
Story C. Landis, Ph.D.
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Frank Leonard
Senior Director
Commercial Operations
Prestwick Pharmaceuticals
Sue Levi-Pearl
Vice President
Medical and Scientific Programs
Tourette Syndrome Association
Paul Lombroso, M.D.
Child Study Center
Yale University School of Medicine
Ernie Lyons, Ph.D.
Scientific Review Administrator
Scientific Review Branch
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Robert Macdonald, M.D., Ph.D.
Professor and Chairman
Department of Neurology
Vanderbilt University
Laura A. Mamounas, Ph.D.
Program Director
Neurogenetics and Development
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Carol Mathews, M.D.
Associate Professor
Program for the Genetics and Epidemiology of Neuropsychiatric Symptoms
Department of Psychiatry
University of California, San Francisco
John M. McCall, Ph.D.
Senior Consultant
PharMac LLC
James T. McCracken, M.D.
Child and Adolescent Division of Psychiatry
Semel Institute for Neuroscience and Human Behavior
University of California, Los Angeles
William M. McMahon, M.D.
Department of Psychiatry
University of Utah
Thomas Miller, Ph.D.
Program Director
Department of Technology Development
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Jonathan W. Mink, M.D., Ph.D.
Associate Professor
Child Neurology Program
Department of Neurology
University of Rochester
Michelle M. Morrow, Ph.D.
Postdoctoral Researcher
Department of Neurobiology
University of Pittsburgh
Tanya K. Murphy, M.D.
Associate Professor and Chief
Division of Child and Adolescent Psychiatry
Department of Psychiatry
University of Florida
T. Celeste Napier, Ph.D.
Department of Pharmacology
Stitch School of Medicine
Loyola University Chicago
Kara A. Nyberg, Ph.D.
Science/Medical Writer
Joseph J. Pancrazio, Ph.D.
Program Director
Division of Extramural Research, Repair and Plasticity Cluster
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Gahan Pandina, Ph.D.
Clinical Management
Janssen Medical Affairs
Janssen, LP
David Pauls, Ph.D.
Psychiatric and Neurodevelopmental Genetics Unit
Center of Human Genetic Research
Massachusetts General Hospital
Harvard Medical School
Alan L. Peterson, Ph.D.
Behavioral Medicine
Department of Psychiatry
University of Texas Health Science Center at San Antonio
John C. Piacentini, Ph.D.
Professor in Residence
Child and Adolescent Psychiatry
University of California, Los Angeles
Carlos R. Plata-Salaman, D.Sc., M.D.
Global External Research and Development
Eli Lilly and Company
Eldrige D. Proctor, M.P.A.
Legislative Associate
Government Relations
Tourette Syndrome Association
Jean-Baptiste Riviere, M.Sc.
CHUM Research Center
Université de Montréal
Floyd R. Sallee, Ph.D., M.D.
Department of Psychiatry
University of Cincinnati School of Medicine
Krish Sathian, M.D., Ph.D.
Department of Neurology
Emory University School of Medicine
Lawrence D. Scahill, Ph.D., M.S.N.
Child Study Center
Yale University
Mark Scheideler, Ph.D.
Program Director, Molecular Libraries
Technology Development
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Nenad Sestan, M.D., Ph.D.
Assistant Professor
Department of Neurobiology
Yale University School of Medicine
David Silbersweig, M.D.
Functional Neuroimaging Laboratory
Department of Psychiatry
Weill Medical College of Cornell University
Harvey S. Singer, M.D.
Haller Professor of Pediatric Neurology
Department of Neurology
Johns Hopkins University School of Medicine
Giovanna M. Spinella, M.D.
Science and Program Consultant
Office of Rare Diseases
National Institutes of Health
David Stamler, M.D.
Chief Scientific Officer and Head
Department of Research and Development
Prestwick Pharmaceuticals, Inc.
Matthew W. State, M.D., Ph.D.
Harris Associate Professor
Department of Genetics
Child Study Center
Yale University School of Medicine
Peter L. Strick, Ph.D.
Department of Neurobiology
Co-Director, Center for Neural Basis of Cognition
University of Pittsburgh
Denis G. Sukhodolsky, Ph.D.
Associate Research Scientist
Child Study Center
Yale University School of Medicine
D. James Surmeier, Ph.D.
Professor and Chair
Department of Physiology
Feinberg School of Medicine
Northwestern University
Susan E. Swedo, M.D.
Associate Director for Pediatric Research
Chief, Pediatrics and Developmental Neuropsychiatry Branch
National Institute of Mental Health
Neal R. Swerdlow, M.D., Ph.D.
Department of Psychiatry
School of Medicine
University of California, San Diego
Judit Ungar, M.S.W.
Tourette Syndrome Association
Flora M. Vaccarino, M.D.
Associate Professor
Department of Neurobiology
Child Study Center
Yale University School of Medicine
Robin M. Voigt
Ph.D. Candidate
Department of Pharmacology and Experimental Therapeutics
Loyola University Chicago
Ann E. Wagner, Ph.D.
Neurodevelopmental Disorders Branch
Division of Pediatric Translational Research and Treatment
National Institute of Mental Health
National Institutes of Health
John T. Walkup, M.D.
Associate Professor
Division of Child and Adolescent Psychiatry
Department of Psychiatry
Johns Hopkins University School of Medicine
Judith R. Walters, Ph.D.
Section Chief
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Lucinda K. Wilson
Senior Project Director
Clinical Division
Prestwick Pharmaceuticals, Inc.
Dean F. Wong, M.D., Ph.D.
Department of Nuclear Medicine/Radiology
Johns Hopkins University School of Medicine
Douglas W. Woods, Ph.D.
Associate Professor
Department of Psychology
University of Wisconsin-Milwaukee
Anne B. Young, M.D., Ph.D.
Neurology Service
Department of Neurology
Massachusetts General Hospital
Harvard Medical School
Samuel H. Zinner, M.D.
Assistant Professor
Division of Genetics and Developmental Medicine/Pediatrics
Center on Human Development and Disability
University of Washington
Last Modified March 9, 2011


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Temporary Wafer Bonding
Temporary bonding and debonding are two main technologies for 3D integration, as well as for other processes such as TSV fabrication, microbumping, wafer thinning and backside RDL formation.
Selecting a suitable adhesive for temporary bonding is key to ensuring a reliable result in thin wafer processing. The mechanical properties and chemical stability of the adhesive must meet the material specifications applying to production processes.
Mechanical debonding at room temperature and excimer laser assisted debonding meet all normal requirements applying to the debonding process.
Overview of technologies by SUSS MicroTec
Temporary Wafer Bonding
Temporary Wafer Bonding
To minimize the risks in thin wafer handling, the wafer is mounted on a carrier wafer prior to thinning. Bonding is only to facilitate further processing – the bond is designed to be dissolved once the wafer is processed.
Process steps required for temporary wafer bonding
- Application of release layers (coating or plasma deposition)
- Adhesive coating
- Bonding
- Thermal or UV curing
SUSS MicroTec offers an open platform that is compatible with all common material systems used in temporary bonding. In addition to the methods already used in production today, SUSS MicroTec is devoted to ongoing work towards qualifying new materials, in this way supporting the largest selection of adhesives currently available in the market.
Customer benefits
- Open bonding platform supporting flexible configuration and all common adhesives and techniques
- Coating of bonding and release layers, including temporary bonding, in one system
- Integrated metrology to determine wafer thickness and TTV
Mechanical Debonding
Mechanical Debonding
Various combinations of adhesive and release layers are available on the market that enable mechanical separation of the carrier wafer from the wafer before further processing. It is consequently essential to be able to vary parameters such as debonding speed and the debonding force applied in order to support the method applied in the particular case. The process needs to be controlled and monitored. During debonding, the thin wafer remains attached to dicing tape in order to facilitate further processing after being released from the carrier wafer.
The mechanical debonding processes supplied by SUSS MicroTec run at room temperature and are suitable for all common adhesives and techniques for temporary bonding. After debonding, the wafers require cleaning in order to remove any adhesive or release layer residues. Certain types of dicing tapes for mounting wafers have only limited resistance to cleaning media. Such tapes require protection during wafer cleaning.
Customer benefits
- Open bonding platform supporting flexible configuration and all common adhesives and techniques
- Controlled, monitored debonding process
- Special protection during wafer cleaning allows unlimited choice of dicing tapes
Laser Debonding
Laser Debonding
SUSS MicroTec's laser debonding technology uses glass carriers with sufficient transmission at the wavelengths used in debonding processes. The adhesive is released by means of irradiation using a 248 nm or 308 nm excimer laser. In contrast to a solid state laser, the excimer laser breaks the adhesive's chemical bonds in close proximity to the glass carrier interface. Considered a room temperature process, this debonding method results in no thermal stress at the debonding interface and achieves very high throughput.
Customer benefits
- Laser debonding is compatible with a great variety of thermoplastic adhesives
- Standard glass carries requiring no special release layer are used
- Thin wafer is subjected to no thermal stress


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12 CFR 615.5245 - Limitations on association preferred stock.
|Updated to:
|January 2014
Title 12: Banks and BankingCHAPTER VI: FARM CREDIT ADMINISTRATION SUBCHAPTER B: FARM CREDIT SYSTEM PART 615: FUNDING AND FISCAL AFFAIRS, LOAN POLICIES AND OPERATIONS, AND FUNDING OPERATIONS Subpart I: Issuance of Equities 615.5245 - Limitations on association preferred stock. (a) The board of directors of each association offering preferred stock must adopt a policy that addresses the association's conditions or limits on the amount of preferred stock that any one holder, or small number of holders may acquire. (b) Each association offering preferred stock must make the stock available for purchase to each of its members on the same basis. (c) An association may not extend credit for purchases of preferred stock in the association. [70 FR 53908, Sept. 13, 2005]


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About TrueStoryFolks : I just like to play basketball and chill.
TrueStoryFolks's FML badges
You've now voted that they totally deserved it more than 100 times.
Supersize Menu
You wanted you know what the top of the flops of all time was, and now you know.
Santa Claus
You've looked for Santa absolutely everywhere, and you managed to find him. Well done!
TrueStoryFolks's favorite FMLs
Today, at my college, someone snatched my laptop out of my hands, so I chased him. Turns out I'm so overweight and slow that he moonwalked away facing me, while I sprinted my heart out. FML
by Jif_Creamy / 02/28/2016 at 12:00am / United States (District of Columbia) / Miscellaneous
Today, at my job drug testing high schoolers, I see that one of the kids selected for the testing looked incredibly high. So, after he goes in the bathroom and gives me his cup with his urine inside, I take a closer look and see that the little shit jizzed in the cup. I hate my job. FML
by zachhewett / 02/02/2016 at 5:53pm / United States (Alabama) / Work
Today, I called the cops on my elderly neighbor for blaring loud war music yet again. They chatted and laughed with him on his lawn for a good half hour. As they left, he slapped the female officer's ass, only for her to just giggle about it. After they drove off, he fired up his music again. FML
by Anonymous / 01/30/2016 at 12:07am / United States (California) / Miscellaneous
Today, I felt kind of horny for once, so I texted my boyfriend to let him know he'd be getting some action later. He replied "I'm gonna fucken murder ur pussy when I get back!! :D" And just like that my sex drive once again crashed through the floor. FML
by Anonymous / 01/16/2016 at 1:40am / United States (Colorado) / Intimacy
Today, I was going to have sex with my boyfriend for the first time. He couldn't get hard and pouted about it for nearly two hours. When I went to comfort him, he said "Man, I hope I'm not gay." FML
by Anonymous / 01/14/2016 at 11:51pm / United States (California) / Intimacy
Today, I recently burned both my hands at work so I had to ask my husband for help changing my tampon, but he refused saying it would make him feel sick. This from the man who routinely sticks his tongue in my asshole when we have sex. FML
by anne / 01/07/2016 at 7:00am / Germany / Intimacy
Today, I showed my husband a recipe for the meal I wanted us to make tonight. He saw cumin was an ingredient and broke into hysterics. By the time he managed to stop laughing, he gasped that he couldn't eat something "with cumin it" and broke down laughing again. FML
by -__- / 12/26/2015 at 8:41am / Miscellaneous
Today, I found a disturbing video on my 8-year-old's tablet. In the video, I was suffering from sleep paralysis. He's convinced I'm part demon. FML
by mommiedearest / 12/24/2015 at 11:06am / United States (South Carolina) / Kids
Today, I came home to my mentally unhinged roommate jacking off to a frozen TV frame of Peggy Hill from King of the Hill. When he saw me, he threw an ash tray at me and told me to get out. FML
by Anonymous / 12/07/2015 at 7:40pm / United States (Oregon) / Intimacy
Today, I walked in on my brother jerking off to a breast cancer awareness advert. FML
by ugh, why / 11/22/2015 at 12:12am / Australia / Intimacy
Today, I finally felt ready to lose my virginity with my boyfriend. Unfortunately he was too embarrassed to go and buy some condoms, and suggested in all seriousness that we use a sandwich bag instead. FML
by angelisa / 11/21/2015 at 9:54am / United States (California) / Intimacy
Today, four days after moving into my new house, I woke up to a guy yelling "Fuck you, Claire" followed by a brick smashing through my living room window. Now I know why Claire was so eager to finalize the sale. FML
by Anonymous / 10/16/2015 at 1:12pm / United States (Alaska) / Miscellaneous
Today, I walked into the restroom at work to see my boss standing at the urinal, pissing like a toddler. He had his pants around his ankles, ass fully exposed. Now I'm never going to be able to take anything he says seriously. FML
by Anonymous / 10/16/2015 at 9:31am / United States / Work
Today, my boyfriend decided to suddenly stop in the middle of sex, just as I was actually starting to enjoy myself, just to bear hug me and exclaim, "Crikey, she's angry!" in the voice of Steve Irwin. He laughed so hard at his own joke that he went soft and couldn't continue. FML
by Anonymous / 05/16/2015 at 5:11am / United Kingdom (Aberdeen City) / Intimacy
Today, I was on my way to work when my ex-wife drove past me in the car she got from me. She fucked me over so hard in the divorce that I have to ride my bike to work while wearing a full suit. FML
by D: / 02/19/2015 at 3:45pm / United States (Colorado) / Money


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Living In China…Seriously
When describing how my first week in Shanghai is going, friends and family ask me: "Have you been to (insert tourist attraction here)?!?!" In short, yes, I have, but only for a few hours. The majority of my time is spent living in Shanghai for real. I am staying at a University that is on the outskirts of the city. There is no tourism in this part, which I find out everytime I try to ask someone for something because no one understands me. I have made several chinese friends (all encounters begin with "Do you speak English?") here who take me to places where locals go. Usually these places involve eating (a lot) but the best is when we play basketball. It's not the fact that I like to play basketball a lot (which I do) but it's an experience that tourists simply don't get. I am the only non-chinese person on the basketball court complex – consisting of 9 courts. It is evident that tourists don't usually play here when I step foot on the court and 150 pair of eyes stare at me (not exaggerating). But as soon as the ball is checked in and we start playing, I become one of them. I was surprised that all of the people I was playing with knew the basketball vocabulary in English (shoot, dribble, foul, out of bounds). Even if they didn't know the vocab, it wouldn't have mattered, because it seems that the rules of pick-up basketball extend beyond language and culture because they didn't need to tell me how to play, i knew.
So while I haven't spent that much time at the Bund, Nanjing Rd, the Shanghai museum, Old town (etc..) – the places all of the travel books and websites say are so important to go see – "you haven't been to shanghai if you haven't visited (insert tourist attraction here)" I am pretty confident in saying that even if I never go to the "must see" places, I have definitely experienced and been to Shanghai.


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Below we have run the 30 largest country stock market ETFs through our custom trading range screen (available to Institutional clients). For each country ETF, the dot represents where it currently stands within its trading range, while the tail represents where it was trading one week ago. A red dot means the ETF has moved lower within its range over the past week, and every single one of the ETFs highlighted currently has a red dot.
Last week at this time, 28 of the 30 country ETFs listed were in overbought territory. After big declines over the last two days, just six of them remain overbought. But while global stock markets have moved lower, a large majority of them remain in uptrends and above their 50-day moving averages. Investors have been screaming for a pullback so that they can get back in. With their feet now to the fire, will they be able to hit the buy button?


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Acrylic Sheets 12"X12" 25/Pkg - Clear
by Acrylic | Item #: 753066 | Model #: 368769 |
We're sorry, this item is not available in your selected Club. Check another Club
About this itemA must have for every Scrapbooker and Crafter!
Perfect for creating unique scrapbook layouts and home decor projects. This 12 x 12 sheet can be cut with scissors, used with a Sizzix Accu Cut, and so much more! Create your own one of a kind shapes with this product! 25 Sheets per package.
Assembled Country
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Elaine Wexler-Mitchell was a veterinarian and she was a specialist on cats. She is the owner and originator of The Cat Care Clinic in Orange, California. She is a former president of the Academy of Feline medicine and served on the board of The American association of Feline Practitioners. She is certified in feline practice. She also is a member of these veterinary organizations, AVMA, AAHA, SCVMA, and CVMA. She also adds a column in the Cat Fancy Magazine called the "Ask the Vet". She received an undergraduate degree in biology from Cornell University and her D.V.M. degree from the Virginia-Maryland Regional Collage of Veterinary Medicine. She is also married to the owner of two Somali cats -Keiki and Shaka, we think those are the cats in the picture.
for more information:
Cat Care Clinic Doctors
by Nick B., fourth grade, 2008
last edited 04/15/2008


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27 posts tagged with Estonia.
Displaying 1 through 27 of 27. Subscribe:
Revenge for Eurovision: Will Russia invade the Baltics?
As Putin continues to probe, and another commentator predicts Russia will invade Estonia, Latvia and/or Lithuania within a year (also, Independent), it's useful to revisit Article 5 of Nato. Recently, the BBC simulation ended in a result of nuclear weapon use, which did not go down well, while another study also indicated results of either a Russian victory or nuclear war. Earlier in the year, Newsweek analysed this scenario; the Chicago Tribune blames NATO, as does The Nation, while The Master Plan considers ongoing Russian shenanigans.
Gee, I wish we had one of them doomsday machines.
How World War III became possible: A nuclear conflict with Russia is likelier than you think (SLVox).
Looking for a tree with a story
Get e-stonianshiped
Become an e-Citizen of Estonia! Estonia is the first country to offer "e-citizenship" (more) and others are looking to follow. "This is the beginning of the erosion of the classic nation-state hegemony.. Estonia's move offers a tantalising hint of a new world order that transcends the nation state." Rights are currently limited (no voting for example) but anyone can apply and there are benefits.
Heavy metal...with a traditional touch!
Fans of history, mythology, language, and music: allow Metsatöll's Lauri Õunapuu to present his arsenal of traditional Estonian instruments. Then continue below the fold for an introduction to the world of folk metal. [more inside]
Estonia, with a population of 1.3 million, might just have the most technologically forward-thinking government around.
A Sea Story
A Sea Story: One of the worst maritime disasters in European history [....]
Another gripping account by William Langewiesche. (Previously: 1, 2, 3, 4, 5, 6, 7, 8, 9)
Another gripping account by William Langewiesche. (Previously: 1, 2, 3, 4, 5, 6, 7, 8, 9)
Eine murul / Breakfast on the Grass is a stop-motion animation answering one of Art's most enduring mysteries: why are those people sitting like that? (SLVimeo, 4:30)
Louis Kahn: the brick whisperer
"Inspired by ruins, DNA and primary geometry, Louis Kahn was one of the 20th century's most influential architects. Why isn't he more famous? Oliver Wainwright on the life and legacy of a man who died bankrupt" ~ The Guardian
The most insane Eurovision contest performance you'll ever see, courtesy of Winny Puhh with their song Meiecundimees üks Korsakov läks eile Lätti. [more inside]
Out of ammo, nearly dead, monsters outside. But! I have a can of meat.
If Doom and Nethack lived in Estonia and had a baby, it'd be named Teleglitch, a recently released pixelated action roguelike that will completely murder you if you're not very careful about how you explore its procedurally-generated corridors, fighting off former coworkers, crafting spare parts into new stuff and hunting for ammo and food and clues as to what the hell went so terribly wrong at the Militech R&D facility on Medusa 1-C. The game has a 4-level demo (Windows and Linux, Mac too apparently) which will probably kick your ass plenty all by itself. [more inside]
You wouldn't get that on Daybreak
Winny Puhh, a finalist for the Estonian entry in the Eurovision Song Context, perform live on Estonia's prime breakfast TV show. You might want to turn your volume down a touch. [more inside]
New worlds of wonderful sound
"Far From Moscow is a resource designed to promote, catalog, and consider new music from Russia, Ukraine, and Belarus, together with the Baltic nations (Latvia, Lithuania, Estonia)." Posts are frequent and extensive and stuffed full of fantastic songs. They also offer a dozen free sampler albums; I'm listening to and loving Apples and the more ambient Forest. [more inside]
Arvo Pärt
[Arvo] Pärt's mature style was inaugurated in 1976 with a small piano piece, "Für Alina", that remains one of his best-known works. It is governed by the compositional system that he called "tintinnabuli," derived from the Latin word for "bells." The tintinnabuli method pairs each note of the melody with a note that comes from a harmonizing chord, so they ring together with bell-like resonance. [more inside]
1989, revolution in Eastern Europe
The BBC World Service has put together a special report on the 1989 revolutions in Eastern Europe (they also have a simpler portal). There is a wealth of material, including TV reports on key events from the BBC archives, interviews, a map timeline, a report on Catholicism's role in the 1989 revolutions, a first-hand report of what it was like to gather news in East Germany during that time and much more.
A Conversation with Vanessa Winship
The Singing Revolution
Some revolutions are about hate. Others are about revenge. But there was at least one that was about hope and music. The Singing Revolution is the story of how hope and music saved a nation. [more inside]
How do you say 'Get me off this crazy thing!' in Estonian?
Fuck Yuo I am a Robot
Fuck Yuo I Am a Robot are offering their album Compensator for the Accelerator for free download from their site. Infectious ass-shakin' Estonian electro-pop. Lyrics to track 2 NSFW, likewise sleeve art jpgs if you opt for the .zip download. You can sample one of the tracks, Hydraulic, on YouTube if you don't know them and would like to check them out first, though personally I can't get enough of Zukunft (direct mp3 link).
WW2 Tank Recovered
Estonian hobbyists find WW2 Russian tank in a bog. And it runs. (via Linkfilter)
Estonian trader hack nets 7.8 million
Oh, the tangled webs we weave when we practice to deceive... Two traders with Estonias most prestigious financial firm spider the Business Wire website and manage to read headlines of impending news stories effectively enabling them to time the market to the tune of 7.8 million in profit...
Estonian soviet-era TV-ads
Mayday, mayday, Estonia, please.
"Mayday, mayday, Estonia, please." 10 years ago tonight, 852 people lost their lives in the cold dark waters of the Baltic Sea. In the middle of the night the ferry M/S Estonia, headed from Tallinn to Stockholm, suddenly capsized and sank. Only 137 people survived Europe's worst maritime disaster since World War II. (more inside)
The 25 Member EU
The European Union welcomes 10 new members! As I write this, the celebrations have started as Cyprus, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Malta, Poland, Slovakia and Slovenia become members of the EU today. While some folks are gonna party like crazy, others are warning of doom and gloom. What do you think? Will this have significant effects on global culture, politics, and economics - or will it merely represent a paper change within the rarefied world of European diplomats, with little other than localized effects on day to day life?
Forest Brothers
The Forest Brothers spent years hiding in the woods of Estonia and Latvia. They lived alone, carefully covering their tracks, sleeping in clammy bunkers, no bigger than walk-in closets. Then things got less comfortable. (warning: nytimesfilter.)
Estonian Deportation
Exhibition of Deportation 14 June 1941. Some history, moments and life stories. Via the Estonian National Museum.
Estonia set for online elections.
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Cavendish Farms has purchased the Appetizer division of Omstead Foods. Also this week: Mission Produce Inc., Tree Top Inc., Produce Marketing Association, Synergy Restaurant Consultants, Blodgett Ovens, TurboChef, Trade Show Exhibitors Association, Server Products, and Mid-Atlantic Food, Beverage & Lodging Expo. MONCTON, New Brunswick, Canada -- Cavendish Farms, a leading supplier of frozen potato products, has acquired the Appetizer division of Omstead Foods. The acquisition ...
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Don't Use Your Credit Card for Cash Advances
Don't Use Your Credit
Card for Cash Advances - We all have times where we get into a
jam and need a little bit of additional money, but don't use...
read entire tip
At times an individual may encounter the unpleasant experience of losing a Savings Bond to theft, damage, or other misfortune. Lost Savings Bonds may not be entirely lost considering there are several steps that a person can take to rectify the situation. Also, a Savings Bond can be replaced or redeemed without paying a fee. It does not matter what series the Lost Savings Bonds may be, the procedure is the same for all.
Sometimes, when the individual orders a bond and does not receive it within fifteen business days--the bond becomes lost even before he has received it. First, he should contact the institution where the bond had been purchased. The institution will investigate the reason why the individual did not receive the bond and will help in filling out a claim form to request a replacement bond. If an individual does not receive a bond which was bought through a Payroll Savings Plan, he should contact the employer's payroll office for a claim form.
Of course, the individual can go online to begin the process of replacing the bond. The appropriate form is provided on the Treasury Direct Website (treasurydirect.gov). This form is Public Debt Form 1048--Claim for Lost, Stolen or Destroyed United States Savings Bonds. First, the individual needs to read the instructions and note the mailing address to send the completed form. If exact issue dates are not known, dates can be estimated with the word "unknown" inserted for any denominations, serial numbers or anything else unknown. Certainly, the more information the individual can provide, the better the likelihood to find the records of the bonds. At the least, the person needs to provide his name and Social Security Number.
After the completion of this form, he must take it to a financial institution that deals with Savings Bonds and have his signature certified. Most banks, credit unions, and savings and loans deal with Savings Bonds and adequate identification must always be shown for the signature certification. After this, the individual should mail the form to the provided address. Once the Treasury receives the form, it will search for the bonds in its records. When the records are found, the Treasury will affirm whether or not the bonds have been cashed. The claim form will show if the individual has decided to have the bonds replaced or redeemed. To prevent a Lost Savings Bond, the individual should always have a complete inventory listing of bonds and their serial numbers kept in a safe place for future reference.
Boyce Wellman said:
How do I find out if I have Canada Savings Bonds, which were accumulated when working in Ontario? Thanks
192.168.1.1|192.168.1.1|192.168.1.1|192.168.1.1 said:
To prevent a Lost Savings Bond, the individual should always have a complete inventory listing of bonds and their serial numbers kept in a safe place for future reference.
Definition: Amortization refers to the gradual reduction of an intangible asset (such as goodwill) on the balance sheet. It can...
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NCAA Women's Division II Tournament Field
by Mark Macyk | LaxMagazine.com | Twitter
|All-time NCAA points leader Jackie Sileo and the LIU Post Pioneers are the No. 2 seed in the North. (Scott McCall)
Adelphi and Limestone, the only two teams to make it through the Division II women's lacrosse season undefeated, were rewarded on Sunday night with the top seeds in the North and South Region for the NCAA tournament. If the seedings hold, we'll see a rematch of of the 2011 NCAA championship game on May 18, in Salem, Va.
That is no guarantee, as six other teams stretching from the shores of the Long Island Sound to the banks of the Mississippi River will look to spoil those perfect seasons. But in the first round, we are guaranteed three rematches, all of games played over the last month.
The fourth seed in both regions, Saint Anselm in the North and Lindenwood in the South, are making their tournament debuts. Both teams will also be looking to avenge big losses. Limestone dispatched Lindenwood, 15-7, on Saturday. Adelphi took care of Saint Anselm, 21-11, on April 12.
The 2/3 game in the North will feature a rematch of a thriller from two weeks ago, as No. 3 New Haven heads to No. 2 LIU Post. The Pioneers rallied to win that game, 14-13, which allowed them to hold on the the No. 2 seed even after a loss to Dowling in the ECC title game.
At the start of last week it was not even clear whether the PSAC would have a representative in the NCAAs. A big showing in the conference tournament not only got Lock Haven in, but gave the Bald Eagles a first round home game as the No. 2 seed. They'll host No. 3 Pfeiffer, which leapfrogged Lindenwood thanks to its head-to-head victory in March.
May 10: NCAA Division II Tournament First Round
North Region
No. 4 Saint Anselm (13-4) at No. 1 Adelphi (19-0), noon
No. 3 New Haven (16-3) at No. 2 LIU Post (17-1), noon
South Region
No. 4 Lindenwood (14-3) at No. 1 Limestone (18-0), noon
No. 3 Pfeiffer (13-4) at No. 2 Lock Haven (17-2), noon
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SYNOPSIS: "Follows a group of high school students growing up in southern California, based on the real-life adventures chronicled by Cameron Crowe. Stacy Hamilton and Mark Ratner are looking for a love interest, and are helped along by their older classmates, Linda Barrett and Mike Damone, respectively. The centre of the film is held by Jeff Spicoli, a perpetually stoned …Read More »
Home | Tag Archives: Sean Penn
Tag Archives: Sean Penn
Film Review: U-Turn (1997)
SYNOPSIS: "When Bobby's car breaks down in the desert while on the run from some of the bookies who have already taken two of his fingers, he becomes trapped in the nearby small town where the people are stranger than anyone he's encountered. After becoming involved with a young married woman, her husband hires Bobby to kill her. Later she …Read More »


text: Newstalk 1060's Morning Edition | WRHL http://www.wrhl.net/pages/index.cfm?id=489 Newstalk 1060's Morning Edition 2016-12-05T08:51:05Z Newstalk 1060's Morning Edition Start your day with Newstalk 1060's Morning Edition! Weekday Mornings 6-9am with Jay Burlison, News & Sports with Jeff Leon and weather with Storm Team 23 WIFR Jeff Leon: Start your day with the information you need.You get the local and area news with WRHL News and Sports Director, Jeff Leon. He has been delivering the local, regional and state news and sports on WRHL since 1981. Jeff is also the radio voice of the Rochelle Hubs for High School Football, Basketball, Baseball and Softball. You get the news and sports first and everyday on WRHL Newstalk 1060. Jay Burlison: Jay is from Rochelle and brings listeners a refreshing approach to mornings with The Morning Edition. With regular interviews with area leaders and entertainment also Area Chamber of Commerce leaders, and many other interviews throughout each month. Plus you will enjoy interesting information & programs with the Morning Edition. Morning Edition Program Schedule: 6am CBS News 6:06am Local News/Sports/23 Storm Team Forecast 6:10am RFD Ag Weather Update 6:18am Farm Progress America 6:25am Dairy Update 6:27am Community Events/Town Crier 6:30am Osgood File 6:34am Local News/Sports/23 Storm Team Forecast 6:43am RFD Livestock Report 6:45am Brownfield Ag News 6:47am Hub City Senior Center Update 6:51am Bob Vila's Tip of the day 6:52am Rewind (Today In History) 6:55am Birthday Club 7:00am CBS News Round Up 7:10am Local News/Obits/Sports 7:27am 23 Storm Team Forecast 7:30am Osgood File 7:35am Local News/Sports 7:46am 23 Storm Team Forecast 7:50am Focus on the Family 7:55am Think Fast! 8:00am CBS News 8:06am Local News/Sports 8:23am 23 Storm Team Forecast 8:30am Osgood File 8:35am NFL Network Now Report 8:37am NCAA Today (Friday's Only) 8:39am Farming America 8:42am Brownfield Ag Weather 8:50am RFD Opening Markets 8:51am Rural Health Today 8:55am CBS Health Watch 8:57am Raising Our Kids WRHL 2016-12-06T01:51:05Z http://www.wrhl.net/pages/index.cfm?id=489