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Sound: The bands sound in Leviathan is quite impressive. Before I decided to sit down and listen to this opus of an album, I wasn't a Mastodon fan at all. But, this album changed my opinion of the band. The concept of the album is based loosely around lauded book Moby Dick, and also represents the element of Water in the bands line of elementally themed releases.The guitars on the album really compliment the Water based theme of the album. The guitar tone fits really well, and the riffs have a watery, seasick feel to them. The drums of Brann Dailor are amazing as usual, and his Jazz influenced metal style really shines on this album. The overall composition of the songs is impressive; as each song holds it's fair share of tempo changes, and and almost all of the songs have technically skillful instrumental breaks. The songs are generally mixed really well, and have a fair balance going for all the instruments. The vocals are dynamic and over all solid, and vary from track to track. As some tracks tend to be heavier on the melodic singing of Bassist Troy Sanders and Guitarist Brent Hinds. And, some tend to focus more on their roaring growls and screams. The only complaint that I have for the album, is the volume of the vocals, that sometimes tend to be kind of quiet in comparison to the rest of the instrument. // 10
Lyrics: The lyrics are quite impressive on this album. The whole album maintains relevency to the concepts of water and Moby Dick, lyric-wise. Quite a few of the songs' lyrics have to do with the story of Moby Dick, and have refrences to the story that are quite obvious. As in "Blood and Thunder"'s roaring chorus "White Whale, Holy Grail". Or in "Seabeast" in which the Harpooner Mr. Queequeg is made refrence to "Dear Mr. Queequeg you have been informed your life's been saved". All in all, I'd say the lyrics on this album are out standing, and quite fitting to the motif, and comply to the over all feel of the songs really well. // 10
Overall Impression: Overall, I find Leviathan to be an amazing work of Progressive Metal. Conceptually, Musically, and lyrically. Mastodon has truely released an awesome work of music. I'd reccomend fan's of Metal, Hard Rock, and especially Prog, if you can stand heavier music to check out this opus. // 10
Sound: Sounding totally different to virtually every other band out there, Mastodon have struck gold with their follow-up to 'Remission', their 2001 debut. In terms of of sound, 'Leviathan' picks up where 'Remission' left off, although the band seem much more confident with their blurring of genres and time signitures within off-kilter song structures. No longer do the band sound like they are "trying" to be different; now all aspects of their unique sound seem to have been perfectly merged into a natural whole.
The band take influences from traditional metal and rock acts such as Metallica and Rush, as well as their contempories Neurosis and Clutch, both of whom make guest appearances on 'Leviathan'. Mastodon have also been chosen to support Slipknot and Slayer, along with Hatebreed on the Unholy Alliance European Tour in October 2004, although quite how they fit on that bill and how the "maggots" will react is a total mystery to me!
As far as playing ability is concerned, Mastodon are one of the most confident and tight musical units playing today, led by the incredible drumming of former Today is the Day sticksman Brian Dailor, whose skills sound like that of a man possessed. The rhythm section is completed by Bassist/Vocalist Troy Sanders, whose bass playing goes well beyond the standard of most bands, echoing the late Cliff Burton at times. Guitarists Brent Hines and Bill Kelliher both have serious chops, be it thrash metal of Hank Williams country and western riffs. // 10
Lyrics: 'Leviathan' is a concept album based upon Herman Melville's literary masterpiece Moby Dick, telling the story of Captain Ahab's quest for the White Whale. The lyrics are emotive and stirring, bringing to mind Metallica's early work such as 'The Thing That Should Not Be'. In terms of vocal delivery, Sanders and Hines share the majority of the work using vocals equal parts melody, agression and emotion. On the whole the album is less lyrically repetitive and more melodic than 'Remission', with much more vocal experimentation. The guest work by Niel Fallon and Scott Kelly fits well and adds more texture to 2 of the album's best tracks- brutal opener 'Blood and Thunder' and the epic 14-minute 'Hearts Alive'. // 10
Overall Impression: Christ, I love this album! Roll on No3! // 10
Sound: Crisp, clean, full, and ferocious sound. The music is heavy, forceful, and passionate all at once. Leviathan seems to be extremely well-produced. The overall sound quality is great except for the fact that the lyrics are sometimes drowned out by the rest of the music. I am not sure if I just have bad hearing, am not used to hearing real metal, or if I am correct and the vocals are hard to hear. Although the low volume on the vocals bothers me, I still give Leviathan a 5 for sound, simply because of its crisp sound, which is damn good. // 10
Lyrics: Awesome lyrics based on Moby Dick. Once again, the lyrics are hard to hear, but thank God that lyrics can be found in the booklet. If they were not found in the booklet, I would have to search the internet for crappy, inaccurate lyrics. Besides, I am terrible at interpretting lyrics. The lyrics are not too repetitive and fit like a glove on a hand with the music. // 10
Overall Impression: My overall impression is that Mastodon is a musically strong band who really know what they're doing and know just how to do it. I originally heard of Mastodon when I saw them in 2004 in concert with Fear Factory, Sworn Enemy, and Walls Of Jericho. When I first heard Mastodon on stage, I thought they suck some gigantic testicles. After about five minutes of listening to them, I went and bought a Sworn Enemy t-shirt, then went to the bathroom. However, since I felt like I needed to give Mastodon a second chance, I went and bought Leviathan about two days ago (May 10, 2005). Here's a lesson in life: Try to give things second chances. You never know what you might gain from that. Leviathan is a great CD. I have a feeling this band is going to go far and develop even more with each album they release. Awesome songs are Blood And Thunder, Seabeast, Megalodon, Naked Burn, and the 13:39 minute long Hearts Alive. Yes, It's damn good metal. // 10
Sound: Mastodon is a great band with alot of talent, and they can make some great music. I found out about the CD just browsing through amazon, and bought at my fye store. I'm a big fan of the sludge metal and like the aquatic sound and effects through out the album. Oh yeah! The cover art is awsome too. // 9
Lyrics: This is the lowest point of the album. It doesn't mean it's trash though. I really likes the Moby Dick story through out the album, and fit the aquatic sound very well. Thank god the ltrics came with the album though because some times I couldnt hear what he was saying. I wish he could sing more Ozzy like, like in the song Naked burn, because he can sing well for the musical genre. // 7
Overall Impression: This is one of the best albulms they've made. My favorite songs are "Blood and Thunder", "Megalodon", and "Naked Burn". I like the drums probably the most, but the singing would sometimes get annoying. If some thing awere to happen to it I would buy it again. Although it's not a perfect album it makes you want to see what they will be coming out with next. // 9
Sound: This is a confusing one, very hard to listen to and some of the songs are confusing, messy, and sound out of tune but you keep going back for more. The production is good, not great but it is clear that this band have imeasurable amonts of talent. 'Blood And Thunder' is superb and 'Joseph Merrick' about as far removed from their heavy sound as you can get is a stunning way to end the albumn. Their is a major fusion of influences here, maybe to much at times but their is one thing this albumn definateley is; infectious! // 8
Lyrics: A definate aquatic influence, refereshing to hear a band take acompletely different route lyrically, makes you want to listen rather that hear what is going on. Vocals are a bit out of touch in parts but again strangely this adds to the feel of the albumn and adds to the intrigue their music creates. // 6
Overall Impression: This albumn is not perfect, but it is a very clear indication as to the way metal is going. The sound is big, the music intense, if not a bit messy but after every listen I enjoy it more. This is a must own in my view due to the diversity, don't expect and easy ride, but in the genre of heavy metal why would you want one? // 8
Sound: My first impression was "I will never get that money back from iTunes, curse me!" The reviews from UG said it was good. Ahh how we are misled at times. The sound is (from the guitars) Green Day, detuned, and slowed down, way way down. Most of the songs sound just like the last. At least 3 have very similar intros. I'd like to share that I do not like this album, but I think Mastodon could have done better. // 1
Lyrics: I don't know any of the lyrics, because they guitar drowns them out. They are (I'm pretty sure) about the whole "Moby Dick" theme which is kind of cool, if you're always sailing the high seas in search of vengeance upon the white whale himself. // 2
Overall Impression: I have all of the songs exept for the last one. The 30 second sample of the last song (called somthing like "Joeseph Merrick") had a cool acoustic bit. In my opinion it is the album's greatest point. That's one song, one. I dislike the sound, but I won't say that Mastodon suck. If it were stolen, I'd smile to myself knowing that the person who stole it would be tormented by this album's crap sound. // 2
Sound: After 2002's Reimission, Mastodon released it's follow up. Some people have been saying Mastodon is overatted, but most of thoes people that have said that haven't herd this album, therefore they should keep their mouths shut. Levithan is a masterpiece, and it is the Master of Puppets of this generation. Songs like Naked Burn, Megalodon, I am Ahab etc. are very technical, and are very different from what you hear from metal today. The Musicanship is incredible, drummer Brann Dailor is one of the greatest drummers of all time. On this album Mastodon mixes jazz drumming, sludgy guitar riffs, a hit of grind, and progressive metal wich sounds a lot sounds a lot like Rush meets Meshuggah. There is no weak song on this album. The record is pure perfection and is one of the greatest albums in history. // 10
Lyrics: This record if you don't know is a concept record, the lyrics are based on the book Moby Dick and it's great concept record at that, it's up there with Abigail, Operation: Mindcrime, Demanufature, etc. // 10
Overall Impression: This record is a masterpiece and I highly recommend it for every metal fan. It's an album that will never be forgotten. Buy or die! // 10
Sound: The sound on this album is very raw and crunchy, yet still has that great production quality. A lot of the songs range in tempo, starting a bit slower and slowly building into chaos, or vice versa. This one would have to be my favorite Mastodon album. The music fits right along with the Moby-Dick theme, giving an "epic sea adventure" feel to the entire record. // 10
Lyrics: What's best about Mastodon's lyrics is that they're blended into the music seemlessly, which is especially important with the screamier kind of vocals. Too many of the growls and screams of today's metal feel like they've been awkwardly thrown on top of the guitars, bass, and drum. Most of the time they're overpowering. Mastodon's lyrics on "Leviathan" take an interesting spin on the story of Moby-Dick. One of the most incredible metal songs ever written, "Blood and Thunder", takes on the whale's perspective in lines such as "I think that someone is trying to kill me/Infecting my blood and destroying my mind/No man of the flesh could ever stop me" and "I am completely emersed in darkness/As I turn my body away from the sun". Mastodon knows how to handle lyrics, as well as how to perfectly blend them into each song without them being overpowering. // 10
Overall Impression: As far as Mastodon goes, I am a huge fan of all of their work. "Leviathan" is definitely my favorite album of theirs. The guitar work ranges from blazingly fast to a lower-tempo'ed crunch. If this album were lost, I'd buy it again in a heartbeat. This is an album that any fan of rock can easily rock out to, as it's not as alienating as most metal today. Some of the big names like Lamb of God and Trivium can be a turn off to the rock lover, but Mastodon brilliantly bridges the gap between heavy metal and your average rock. // 10
Sound: Leviathan is considered Mastodon's first true progressive metal album. This concept album based around the tale of Moby Dick and is a sonic journey that will leave you in a state of awe. Leviathan is an unrelenting assault of sludge riffage, guitar harmonies, and mind numbing tempo changes.
The guitar work of Brent and Bill is stellar. These two share a bond and can create absolutely beautiful textures. But what really shines about this album is the drummer. Brann has to be one of the most unusual and interesting drummers of the last decade. He is technical but not to the point of being completely predictable and mechanic. He has a distinct groove and play fills that are absolutely insane. Unlike most of his drummer contemporaries, he doesn't rely on double bass all the time and uses it strategically.
The bassist Troy is a great singer, but his bass playing is by-the-book. Brent occasionally lends his vocal ability and sings wonderfully. The band is wise to include his vocals more in subsequent albums. Every track on this album is a delight to listen to. The songs are each unique sounding and the band does not hesitate to delve into other genres such as thrash, southern rock, and psychedelic rock. Stand-out tracks include the opener "Blood And Thunder", "I Am Ahab", "Sea Beast", "Naked Burn" and "Aqua Dementia". // 9
Lyrics: The lyrics match the mood of the music perfectly. They put images in your mind and weave the tale without being overtly blatant. Many of the lyrics are cryptic and will take multiple listens to truly understand them. Troy sings the majority of the vocals on the album. He has a harsh voice that is able to deliver the energy that is unique to sludge.
But as said earlier, Brent comes in at the perfect moments to sing the cleaner vocals. The entire band provides backing vocals to really beef up the vocals. It's refreshing to hear a metal band that puts as much effort into it's vocals as the actual unspoken music. // 8
Overall Impression: This album is a very tight album that should satisfy even the most stubborn of metal heads. Mastodon has a very distinguished sound that bloomed with this album. Leviathan was a big step into an even larger world of Progressive Metal.
I recommend this album to all my friends who have not been enlightened by discovering this band already. This album has very few weak spots. My only gripe is the lack of keyboards. The last track features some organ work but not enough to satisfy. Fortunately they correct this in their later albums. // 9
Josh Laiho
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A face and name synonymous with international fashion campaigns and catwalk shows, Rachel Ritfeld is the embodiment of diversity — professionally and personally. In life as on the stage, Rachel is many things wrapped into one. Her multicultural heritage: Indian, Black Caribbean and Ghanaian and impressive fluency in over six languages and degree in Social Anthropology helps her further understand the complexities of the world and celebrate diversity on a number of levels. Raised in Brussels, Rachel developed a strong working ethic and a crystal clear focus from a young age which has led her businesswoman persona to be fueled by her compassion towards combating social inequalities worldwide. Parlour Magazine caught up with her for their Maven series to find out how she's building her business successfully.
In a short amount of time, Rachel Ritfeld has had a career that many would dream of. A world traveler who is fluent in five languages, she's been featured in campaigns for L'Oreal and Toni & Guy, and has graced the catwalk for everyone from Jean Paul Gaultier to Baby Phat. You may have also seen her featured in 50 Cent and Justin Timberlake's "Ayo Technology" or as a presenter on the former Sky1 series Project Catwalk.
Now, as a mother, philanthropist and budding actress, Ritfeld has found a new sense of balance and inspiration. As the second installment of our Parlour MAVEN partnership with London's I'mPOSSIBLE Conversation*, we present to you, Ms. Rachel Ritfeld.
You've had a successful career in fashion and entertainment, what are three words of advice you'd offer to aspiring young women?
The majority of my career has been centered around the modeling industry, so the three bits of advice I would give in the field are:
- Make sure you have more to offer than your beauty because beauty fades, make sure you have a decent education to back you up. It will add value to you as a person as well as boost your self- esteem and force people take you more seriously.
- Remember it is entertainment and temporary so have a plan for when the modeling comes to an end.
- Be dignified in everything you do. You cannot build on a bad base, make sure the foundation of who you are, not what you are, is strong!
How has the modeling business changed since you began?
It has changed immensely. There are more models now than ever, and so many are willing to work for free. This makes it very hard for the majority of real professional models to earn a decent living like we did over five years ago. The women who will stand out and make it are the ones with a plan. With intelligence and a good general knowledge of the fashion business and how to market themselves, they can take it to the next level.
What were the biggest professional challenges you have faced?
People trying to put me down because they didn't understand the vision I had for my career. But I never took no for an answer and against the odds and the rejection I had an incredible international career. The only thing that can hold me back is me. I choose not to let people have power over my life anymore. Three years ago I was in a position where I had to step out of the business, but I am grateful now for new opportunities and that I have the maturity required now to go wherever I want to take my career.
Who inspires you?
My daughter, I can't afford to fail. I'm in the process of getting divorced so I have to pull all the strength and focus out of myself right now because I am all she has. I am her example, the concept of what makes a woman will come from me so I cannot allow myself to do anything but succeed. The funny thing is, my daughter's only two years old, but I've been living with her in my head and heart for at least five years. She has been my inspiration for years now.
How has being a mother impacted the way that you view work-life balance?
It's not easy as a single mom to make it all happen, but so far so good. As a mother I am very happy with myself. I lived in Suriname for the past five years and only got back to the UK three months ago. Rosalia is everything I always dreamed of and more, and as time goes by it will get easier…read more at Parlour Magazine.
Come and hear the full story of Rachel's journey at the winter edition of the I'mPOSSIBLE conversation next Wednesday, December 12.

subset: commoncrawl


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Shared devotion
Toward the end of 1960, Trappist monk Thomas Merton, living in a monastery in Kentucky, began a correspondence with Abdul Aziz, a Muslim civil servant in Karachi, Pakistan. Until Merton's death in 1968, the two men exchanged books and long letters in which they discussed their theological differences, introduced each other to their respective traditions of spirituality, asked each other questions about their daily practices of prayer and meditation, and described to each other how they ordered their days. One of the most detailed, personal accounts of Merton's daily life in his hermitage at the Abbey of Gethsemani is recorded in a letter to Aziz.
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Abstract: Cutaneous T-cell lymphomas (CTCLs) are a diverse group of non-Hodgkin's lymphomas that include mycosis fungoides and Sézary syndrome subtypes, affecting mainly the skin. Accurate diagnosis of CTCL variants and the stage of disease are both key factors for determining appropriate treatment strategies. Early-stage disease can often be effectively managed with skin-directed therapies. However, patients with more advanced disease benefit from systemic therapies, which are often associated with toxicities that degrade patients' quality of life. Histone deacetylase (HDAC) inhibitors are a class of targeted agents that prevent deacetylation of histone/nonhistone proteins and affect a wide range of cellular functions regulated by HDACs. Vorinostat and romidepsin are HDAC inhibitors approved for the treatment of CTCL, whereas several others are under clinical evaluation for CTCL and other hematological malignancies. This article reviews important safety considerations with HDAC inhibitors. For dermatology and oncology nurses, identification and management of toxicities are critical to maintaining patient quality of life and ensuring optimal treatment outcomes. Quality nursing care is essential for the successful treatment of patients with CTCL. As newer and more complex options for CTCL are utilized, dermatology and oncology nurses play an important role in educating and managing patients and associated treatment-related toxicities.
Copyright © 2013 by the Dermatology Nurses' Association.
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The Promise: Health We are well along the path to finding much-needed answers for families touched by autism. We are reaching out and making a difference. Watch the video here andRead More
What does it mean to be a scientist? Do they sit around all day in the lab, wearing white coats and peering through microscopes? The answer, emphatically, is no. Watch the video here andRead More
The Arts Studying the arts produces fine scholars who are also active citizens with a passion for life. Watch the video and Read More
Carnegie Foundation: "very high research activity." Carolina is one of 62 public universities nationwide—and the only university in South Carolina—to earn this distinction.Read More
Nationally recognized programs. Chemistry, Biology, History, Literature, Creative Arts and more.Read More


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Many southern white rhino are now concentrated within protected areas such as fenced sanctuaries, conservancies, rhino conservation areas and intensive protection zones. Effective management strategies have resulted in surplus animals being translocated to set up new populations within and outside the species' former range. In a number of countries, populations are now managed by both the state and the private sector, increasing their long-term security. Selling limited sport hunting of surplus males, for example, attracts large revenues and powerful incentives for private sector conservation, and generates much needed funds to help pay the high cost of successfully monitoring, protecting and managing rhino. All rhino were listed on CITES Appendix I by 1977, prohibiting international commercial trade in the species and their products. Following the continued rise in numbers of the southern white rhinoceros subspecies, however, the South African population was downlisted in 1994 to Appendix II, but only for trade in live animals to 'approved and acceptable destinations' and for the (continued) export of hunting trophies (1). Domestic anti-trade measures and legislation were also implemented in the 1990s to help reduce illegal trade (1), and some game managers immobilise white rhinos and remove their horns to deter poachers (4). There are a number of regional and continental African rhino conservation initiatives that advise on or support effective conservation programmes. These include the IUCN SSC's African Rhino Specialist Group, the SADC Rhino Management and Rhino Recovery Groups, the Rhino and Elephant Security Group and the SADC Regional Programme for Rhino Conservation (15). Thanks to the concerted efforts of conservationists, researchers and concerned individuals, particularly in South Africa, southern white rhinos have recovered from just a single population of between 20 and 50 animals in 1895 to about 17,500 today, with an additional 750 animals in captive breeding institutions worldwide, and are now the most abundant kind of rhino in the world (1) (10) (13). Rescued from near extinction a century ago, this subspecies stands as one of the world's greatest conservation success stories (6). Nevertheless, poaching pressure remains an ever-present threat and, with 99% of all southern white rhinos occurring in only four countries, the subspecies is still vulnerable and we cannot become complacent about its conservation (8). Sadly, the outlook for the northern white rhino doesn't look so bright. The Garamba project had managed to conserve the population at about 30 rhinos from the late 1980's up to 2003, but an upsurge in poaching resulted in it declining to only 4 animals in 2006. The most recent surveys have failed to find any evidence of this subspecies in Garamba National Park. If the northern white rhino has now become extinct in the wild, its survival may now depend upon the successful breeding of the small number of rhinos held at Dvur Kralove Zoo in the Czech Republic (1).
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The biggest reason supermarket companies are adding pharmacy departments is to provide a one-stop-shopping experience for their customers. Supermarket pharmacy directors also are aggressively adding new services, including mail delivery and home health care. These were two major findings of a survey of supermarket pharmacy directors conducted jointly by Supermarket Pharmacy and Marketing Corporation of America, Westport, Conn. A total of 276 survey forms were sent to top supermarket chains, ...
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I've always been a Stacey Dash fan. But, I didn't know show was on the right side on politics.
But Mitt Romney also has his backers amongst the celebrity world.
Clueless star Stacey Dash took to Twitter to urge voters to pick Romney for President.
'Vote for Romney. The only choice for the future,' the actress tweeted to her fans.
Stacey also posted a sexy photo of herself wearing a clingy red top while standing in front of the American flag.
But her stance led to a backlash from Obama backers.
'You're an unemployed black woman endorsing @MittRomney. You're voting against yourself thrice. You poor beautiful idiot,' one unhappy critic Tweeted.
'Still clueless,' tweeted another critic.
Stacey, 46, defended her decision to support the Republican nominee by saying, 'My humble opinion...EVERYONE is entitled to one."
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Comprehensive DescriptionRead full entry
Description of Urotricha lagenulaProstomatid ciliate, 45 micrometres. Flask-shaped or pyriform, narrow in front, rounded posteriorly, often with a yellowish coloration. Mouth apical, round, over a thick-walled cytopharynx supported by nematodesmata. At posterior extremity, a tuft of 3 or 4 long caudal cilia. Somatic ciliation uniform, denser and shorter anteriorly, longer and sparser in the rear. Macronucleus large, spherical, slightly subcentral; posterior contractile vacuole. Swims quickly, with orbital, rotating movement, with sudden erratic shifts in direction. Freshwater, in ponds and marshes


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Sipsey 05/27/2006
Sipsey action was good today....they stocked early this week some fish in the 13 to 14 inch range....I couldnt get a dry fly bite....fished black #16 and smaller nymphs.... which worked better....fish were full of ants but I could not see any on the water......very few fishermen this morning
Re: Sipsey 05/27/2006
About the same today.....could see plenty of winged ants on the water *several fishermen...lots of fish late in the afternoon.
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text: Usage Journal of Vision strives to ensure maximum access and visibility for each article. The vision community may be interested in recent progress toward this goal: The journal receives about 2,000 visitors, and about 57,000 hits per day. The number of visitors has doubled in the last year. In 2004, the top five papers were each downloaded an average of 1,235 times. Citation Download You can now download the citation data for any Journal of Vision article by using the "Get Citation" feature on the article abstract page. All of the common reference formats are supported. This works for conference abstracts published in the journal as well. Incidentally, EndNote (http://www.endnote.com/) users can download the entire collection (to date) of Journal of Vision bibliographic data by using the EndNote "Connect->PubMed" command in the "Tools" menu and then searching for "j vis" in the "Journal" field. Andrew B. Watson, Editor-in-Chief Journal of Vision http://journalofvision.org/


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Social media stars in China turn to e-commerce
The growing number of influential Weibo commentators are increasingly opening their own online shops or promoting products.
Social media stars in China turn to e-commerce
The growing number of influential Weibo commentators are increasingly opening their own online shops or promoting products.
Pinterest hires Walmart.com's former head of marketing
As Pinterest's head of vertical strategy, Brian Monahan is tasked with developing and managing the platform's marketing programs across a range of areas, including ...
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70% of retail workers are without corporate e-mail access. Sendmail, Hewlett-Packard and Intel want to change that by providing universal e-mail access through a new service called Workforce Mail.
When a retailer sends a corporatewide e-mail notice, do all employees get the message? In fact, most of them probably don't, says Greg Olson, chairman of Sendmail Inc. "More than half of retail workers don't have access to corporate e-mail," says Olson, whose company provides e-mail systems for 29 Internet service providers. A survey conducted in February for Sendmail by King Research showed 70% of retail workers are without corporate e-mail access.
Sendmail and partners Hewlett-Packard Co. and Intel Corp. want to change that by providing universal e-mail access through a new service called Workforce Mail, which brings the broad accessibility of ISP-based e-mail into a controlled corporate environment. "The key is to make it ubiquitous," Olson says. "I want to put workers in local stores in the loop with headquarters."
Through the Workforce Mail program, Olson says, retailers can extend e-mail access to warehouse workers, cashiers, salespeople and others who don't work at a desktop computer or use a laptop for e-mail access. Built on a Linux platform running on HP servers, Workforce Mail can be deployed through any terminal that can send and receive e-mail, including kiosks and handheld devices. Wireless capability comes from Intel's Centrino wireless platform.
The Workforce Mail system, Olson says, allows retailers to control employees' use of e-mail outside of a more expensive e-mail management system like Microsoft Exchange.
Olson says the system is already being used by two retail chains, including one with 60,000 users, though he would not name the retailers. The cost for the system ranges from $1 to $2 per month per user, including software, network hardware, maintenance and technical support. Costs related to end-user devices, such as PDAs and kiosks, are separate, Olson says.
Most modern POS terminals should integrate with Workforce Mail without much modification, Olson says, although older POS terminals could require extra integration costs.
Be honest with customers about wait times, and make sure agents have all the information ...
Posted 12/07/16
Here are five technologies that can unleash the power of all the data an online ...
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Online retail is hard, grocery retail is really hard, so online grocery is, of course, really, really hard."


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IN Gemini the stability of the Sun is greatly diminished. The first principle of all mechanical efficiency is the fulcrum; a rigid base is necessary for every machine. An enormous proportion of the power developed for locomotion is wasted in hammering out a permanent way. If, therefore, the Sun, which is the fulcrum of the bodily machine, is in a movable, airy, mercurial sign, the working power of the engine is seriously diminished.
If Dante, Wagner, and Queen Victoria seem to be exceptions to this rule, it is because, in their cases, the Sun was still within a degree or two of Taurus and partakes very largely of his nature. In all these cases, too, it was well-aspected.
Speaking generally, people with the Sun in Gemini show a certain vagueness and irresponsibility, finding it hard to concentrate upon any subject or even to take any subject seriously. Even when their lives appear devoted to the prosecution of a particular object, it will seem as if there were no real basis in the nature corresponding to the observed effect. Their actions are prescribed by the mood of the moment, and they do things more because they are personally interested than with the idea of building up any important result for themselves. There is a great tendency to dissipate the force, and, owing to the dual nature of Gemini, such people are always happier when leading a double life. This expression is not used in any equivocal sense; it merely means that they are happiest when they have more than one dominant interest. They cannot stay, according to the expression, with their "noses to the grindstone." Permanent work makes them restless and uneasy in a very short space of time. "Variety is the spice of life" to them, and, especially when Venus and Mercury are both in the same sign, they often become "rolling stones," "Jacks-of-all-trades and masters of none," {10} unless there is some extremely stabilizing influence from a steady-going planet like Jupiter or Saturn, more especially Saturn. Thomas Moore is an excellent example of the lighter talents given by the Sun in this sign, and the versatility of Bulwer-Lytton is also a manifest confirmation of this position.
Most of the force of the constitution and vitality of the native goes to nerve and intellect rather than to heart. We do not, as a rule, find people with warm dispositions having this position of the Sun. Albrecht Durer, Bulwer-Lytton, Schumann, Strauss, are all examples of this. In the cases of Jay Gould and Nero, this coldness of disposition is even more marked.
Gemini rules not only the nerves but the ratiocinative part of the brain, as distinguished from the executive, which is under Aries, the sensory as opposed to the motor function. It also rules the hands and arms and, in particular, the lungs. The general sensitiveness of the nerves is, however, an excellent token of artistry. People with this position of the Sun are likely to hear more, to see more, than the average man. They are open to impressions, even the most delicate, and, where Mercury assists, are able to record them with exquisite fidelity. The intellectual qualities are, moreover, fine and strong. Their apprehension is based on knowledge; their memories are excellent, and they build up splendidly on existing foundations. There is, however, not likely to be any tremendous force of originality in the mind, unless Mercury holds aspects to Uranus or Neptune. The student will remark that even Dante was greatly indebted to Virgil on the one hand, and to the Patristic authors on the other.
Similarly, Wagner went entirely to existing tradition for his material, and a good third of the originality of his music is due to his exquisite sensibility in regard to sound, while his whole plan, particularly the cry of the leitmotif, is rationalistic and literary, rather than musical.
It is part of the Gemini nature to demand a change of scene and relaxation; exercise, sleep and fresh air are necessary to the health, which, however, will never be robust in the same way as we find it when the Sun is in such a sign as Taurus and Leo. The native is really too high-strung and, unless things go his way, he readily becomes depressed. It will be useless for him to endeavor to {11} settle down in any fixed occupation. The best he can do is to try to take advantage, as far as possible, of the qualities of his defects and so to arrange his life that the sword does not too quickly wear out its scabbard.
The following well known persons were also born with the Sun in the sign Gemini:
Elbert Hubbard
Robert M. LaFollette
Richard Mansfield
Walt Whitman
May Allison
Margaret de Alvarez
Elizabeth Marbury
John McCormick
Gene Tunney
Robert W. Chambers
William H. Woodin
Frances Alda
James Montgomery Flagg
Gilbert Emory
Queen Mary of England


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Positive-Outlook, Exceptional-Quality, Beautiful-design, Better-Rates, information available by clicking above. Popular-Choices, Exclusive, Convenient, Cost-effective, Product-superiority, Heavy-Duty, Advantageous, Easy-on-the-pocket, Save-Money
The thinner/solvent is used when the COPALITE Varnish thickens. Add a few drops of the thinner to the thickened varnish, recap the varnish and shake.
There is no other varnish available with the characteristic to reconstitute itself like COPALITE Varnish.
Varnish. It is time tested. The solvents in the varnish have anti-microbial and anti-viral properties.
Dental products, snap bond, dental aids, mouthtray - firstname.lastname@example.com
Manufacturers of Fine Dental Products Since 1933 - firstname.lastname@example.com
Product instructions are now available in Russian, Chinese, Japanese, and more - email@example.com
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It is applied under gold and amalgam restorations - email@example.com
Manufacturers of fine dental products for over 60 years. Copalite Dental Products.
Air dry and reapply varnish, dental health product - email@example.com
To establish the right consistency, compare the color to an unopened bottle.
dental office supply
Distinctive, Beautifully-detailed, Great-Support, Practical, Affordable-Prices, Pleasing, Customer-Service, Great-Prices, Customer-Satisfaction, Great-Prices, Positive-Results, Customer-Service, Beautifully-detailed, Convenient, Easy-on-the-pocket, Beautiful-design, Business-Opportunities, Better-Rates, Save-Money, Distinctive, Popular-Choices, Affordable-Prices, Pleasing, Customer-Satisfaction, Exclusive, Product-superiority, Practical, Great-Support, Exceptional-Quality, Cost-effective, Beneficial, Positive-Outlook, Heavy-Duty, Advantageous, Beautiful-design, Popular-Choices, Exceptional-Quality, Distinctive, Positive-Outlook, Business-Opportunities, Customer-Service, Exclusive, Advantageous, Positive-Results, Product-superiority, Convenient, Save-Money, Great-Prices, Heavy-Duty, Cost-effective, Easy-on-the-pocket, Affordable-Prices, Practical, Beneficial, Customer-Satisfaction, Beautifully-detailed, Pleasing, Great-Support, Better-Rates, Exclusive, Distinctive, Exceptional-Quality, Customer-Service, Product-superiority, Better-Rates, Save-Money, Cost-effective, Customer-Satisfaction, Positive-Outlook, Heavy-Duty, Affordable-Prices, Positive-Results, Easy-on-the-pocket, Pleasing, Convenient, Popular-Choices, Beneficial, Business-Opportunities, Beautifully-detailed, Great-Support, Practical, Beautiful-design, Advantageous, Great-Prices, Easy-on-the-pocket, Exclusive, Customer-Satisfaction, Product-superiority, Distinctive, Advantageous, Popular-Choices, Better-Rates, Positive-Results, Cost-effective, Beneficial, Affordable-Prices, Customer-Service, Practical, Business-Opportunities, Great-Prices, Beautiful-design, Beautifully-detailed, Great-Support, Exceptional-Quality, Save-Money, Pleasing, Heavy-Duty, Convenient, Positive-Outlook, Cost-effective, Affordable-Prices, Exceptional-Quality. .


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Remediation of Area IV and the Northern Buffer Zone of the Santa Susana Field Laboratory
DOE is amending its 2008 notice of intent to prepare an environmental impact statement (EIS) for cleanup of Area IV, including the Energy Technology Engineering Center (ETEC), as well as the Northern Buffer Zone of the Santa Susana Field Laboratory (SSFL) in eastern Ventura County, California, approximately 29 miles north of downtown Los Angeles. (DOE's operations bordered the Northern Buffer Zone. DOE is responsible for soil cleanup in Area IV and the Northern Buffer Zone.) Since DOE's 2008 NOI, extensive studies of the site for radiological and chemical contamination have been ongoing and are nearing completion. DOE is proposing a revised scope for the EIS due to the 2010 Administrative Order on Consent (2010 AOC) that DOE and the California Department of Toxic Substances Control (DTSC) signed for soil cleanup, and due to information now available from site characterization. The scope of the EIS would continue to include groundwater remediation consistent with requirements in the 2007 Consent Order for Corrective Action (2007 Consent Order) issued by DTSC. This Amended NOI describes DOE's proposed action and includes cleanup concepts developed by the local community.
For more information on the project and the scoping meetings, see the project page.


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NINDS encourages grant applications for research on the cause(s), diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS). This announcement is made together with 12 other NIH components and is supported by 2 funding mechanisms: R01 and R21.
CFS is a debilitating and complex syndrome that involves multiple body systems. It is characterized by profound fatigue that is not improved by bed rest and may be exacerbated or rekindled by physical or mental activity. No specific cause or diagnostic test has been identified for CFS. Innovative, well-designed studies are needed to provide a better understanding of the disorder, which will lead to improved diagnostic and intervention strategies.
Potential applicants should contact Dr. Linda Porter, program director, Systems and Cognitive Neuroscience Cluster, NINDS; telephone: 301-496-9964; email: firstname.lastname@example.com. For more information visit http://grants.nih.gov/grants/guide/pa-files/PA-08-246.html or http://grants.nih.gov/grants/guide/pa-files/PA-08-247.html.


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|Download the pdf Guide of Broome
|Print the pdf Guide customized with attractions and things to do
Overall rating:
Rank: 1 About 7
Viewing a sunset from anywhere in Broome is simply stunning, but sitting on the sand dunes, with a wooly jumper to combat the breeze, or snuggle with your partner and this is...
Reviewed by: Lisa Visioli
|Cable Beach
Overall rating:
Rank: 2 About 7
Cable Beach is a very long beach that stretches a staggering 22 kilometers found in the town of Broome, Western Australia. The name Cable Beach evolved because of the long telegraph cable that was laid between Broome and...
Reviewed by: Editorial Staff
|Gantheaume Point
Overall rating:
Rank: 4 About 7
At this point, various fossilized footprints of dinosaurs can be observed at 'low tides'. This place acts as an ideal base with regards to long excursions and day trips in Kimberley region. One can easily spend his/her weekend in...
Reviewed by: Jò
|Caravan Park
Overall rating:
Rank: 5 About 7
Located midway between the blooming townships of Broome and Headland lies this beauty of nature. Assumed to be one of the longest beaches in the world, this beach has a length of 80 miles as the name itself suggests....
Reviewed by: Jò
|Broome 6 Gallery
Overall rating:
Rank: 6 About 7
Broome 6 Gallery goes on to represent the finest of works by Kimberley and Broome artists. It also specializes in work from Kalumburu Community; within Gyorn Gyorn and Wandjina Art Traditions. This gallery is the only one of its kind; as it...
Reviewed by: Jò


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Dear Editor,
We thank Roberta Lowrey for her many years of dedicated service to the Concordia Area Chamber of Commerce! Roberta has worked tirelessly to promote our community and local businesses. We are grateful for all she has accomplished and wish her well in her retirement.
The Board of Directors has not yet hired someone as Executive Director. However, during this interim we are grateful to CloudCorp and to the Cloud County Tourism office, who will help us ensure that we can continue to offer many of the services you rely on such as purchasing and redeeming Chamber Bucks and Chamber coffee on Tuesday mornings at 8:15 a.m. A big thank you to Ashley McMillan, Donna Barrett and Tammy Britt for assisting us.
The Board of Directors will meet in January to explore all of our options as we go forward. If you have ideas you would like us to consider, please contact any board member. Thank you for your patience and support during this transition.
Jean Rosemarynoski, CSJ
Board Chair


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Brine Dynasty Elite Cinch Limited Edition Composite Complete Women's Lacrosse Stick
Only 5 in stock
Team Sales Request? Click Here
- Orders over $49 Ship Free
- Order by 3:00PM EST Monday-Friday for SAME DAY shipping from SportStop.com in NH
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A Recent Favorite:
Uh Oh, Nothing Here Yet
Why don't you go browse some Comics or Editorials and pick a few to favorite?
Recent Comments
I don't care who anyone votes for. Just vote. People who can vote and who don't vote are morons. It is one of the greatest things that we can do in this country. Luann should feel awful. But she's a screw up. All of her friends are getting on with the lives and she's stuck in some community college, living with her parents. What a mess.
Anyone who is eligible to vote and doesn't, deserves to be shamed. And it's funny how the ones who don't vote are usually the ones complaining the loudest.
It seems like Nate is always drawn to these weird people like his Uncle and School Picture guy. Is this supposed to be a cautionary tale, that this is how Nate is going to end up?
I love Chad. He's a great addition to the strip. Who didn't have a "Chad" in your friendship group.
Why did they interrupt the strike storyline?
One of the great things about this strip is the way it gets "guy friendships". He does a great job getting how guys act and sound.
If Greg really wanted to spice things up, Luann would run into Aaron Hill and his family who are moving back to Luann's town.
Must we bring all of this Jesus crap into Bloom County also?
Would someone Teddy's age even know Scott Baio? But I can't think of an actor from the last 10-15 years who has taken over the Baio cheese throne.
Do we know what happened to Nate's mom? Is she dead?


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Denmark's venture capital firm have put the financial crisis behind them and are upping their investments in local businesses according to new research from the company's industry body.
In order to view more content, sign-up to our free daily newsletter.
If you would like to read the premium stories, have complete access to our breaking news and Limited Partner magazine you need to become a Premium Subscriber.


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Wilson2+ weeks old
Seeking a newly remodeled 1 bedroom apartment for $750 with private parking and entrance close to Burke-Gilman Trail, the Sammamish River and Lake Washington. Has to be pet friendly, hard wood floors throughout, on site laundry room, and open floor plan of the kitchen and living room.
Seeking a newly remodeled 1 bedroom ...


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NORTH LITTLE ROCK, AR – Authorities were called to a church in reference to an explosion.
The North Little Rock Police Department said on Wednesday evening, the compressor on the AC unit located on the roof of the Parkhill Baptist Church exploded.
There was not a fire, but the fire department was sent to the scene.
No injuries were reported.
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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Detailed Syllabus for the IBPS CWE I.T. Specialist Officers Professional Knowledge Paper
Though there is no specific syllabus mentioned but the syllabus mentioned below is a part of CAIIB conducted by IIBF and it covers most of the topics in Information Technology. Hence it should be very useful while preparing for the IBPS CWE for IT Officers.
The Basic Syllabus of IBPS CWE for IT Officers will be:
- Computer Basics
- MS Office
- Internet and E-mail
- Internet Security
- Networking
- Business Systems
- Data Structures
- Java
- Unix and Shell
- Computer Engg
- Micro Processors
- Integrated Circuits
- Digital Electronics
The detailed syllabus for CAIIB also helpful for IBPS CWE for IT Officers:
Impact of IT on Banking : Changing Financial Environment and IT as a Strategic Response
Hardware (H / W) - Software : (S / W)
System Software :
Operating Systems (Desktop OS / Server OS) Windows (Desktop / Server) / UNIX (H. P. Unix, Sun Solaris, Linux, IBM AIX)
Computer Languages - 1st Generation Languages (Assembly), 2nd Generation (Fortran, Algol, Cobol), 3rd Generation (C, C++, C# and JAVA etc.) and 4th Generation Languages (Clipper, Power Builder, SQL etc.) and 5th Generation Languages (Logic Programming Languages)
Database Management System and Relational Database Management Systems (Oracle10g, MS SQL-2005, MySQL)
Application Servers (Oracle 10AS, BeWeblogic, WebSheare ) Web Servers (IIS, Apachi etc.) Web Browsers (IE 7.0, Firefox etc.)
Application Software : Packaged Software, Custom built Software etc. Computer Networks, Equipment & Data Communication
Computer Networks : Network Layers, Topologies, Protocols, IP Address Mechanisms, LAN, WAN, VLAN, Intranet, Extranet, Internet,
Network Equipments : Cables (BNC, Twisted Pair, Fibre Optics), Connectors, I/Os, Patch Panel, Jack Panels, Network Racks.
Data Communication : CLL, Leased Lines, MPLS, VPNS, ISDN, Satellite Links, Wi Fi, Wi Max.,
Network / Security Equipments: Modems, Hubs, Switches, Bridges, Routers, Firewalls, NIDS, HIDS, IPS
Systems and Design
Systems Design & Analysis(Data modeling, Entity Relationships, Generic Data Modeling, Semantic Data modeling Normalization( from 1st to 3rd and BCNF, 4th & 5th level of normalization)
Software Development Life Cycle (SDLC) - Various phases of SDLC, In-house /Out-sourcing, Software Project Management, Computer Aided Software Engineering (CASE) Tools.
System Architecture : Clients (Hardware / Software), Servers (Hardware / Software). Client Server Architecture, 3 Tier Architecture, N-Tier Architecture etc.
Data Warehousing - Data Mining tools
MIS and Organization Support Systems - DSS, EIS, GDSS, Groupware and Multimedia Business Intelligence - Expert Systems, Artificial Neural Networks (ANN) Grid Computing, Virtualization and Consolidation.
Applications in Banking
Centralized Banking System / Core Banking System / System Administration, Database Administration, Application Server and Application Administration, Network Administration, Domains, ISPS, Hosting, Data Downloads / Uploads, Band widths, Data Centre, Data Storage Devices, Data Backups / Restoration, Disaster Recovery Centre
Delivery Channels - ATM, EFTPOS, Phone Banking, Internet Banking, SMS Banking, Mobile Banking, Credit / Debit Cards, Smart Cards E-Mails, SMS alerts
E-Commerce - Secure Electronic Transfer (SET), Payment Gateways (Credit card / Debit cards), Authentication of payments etc.
PKI - CCA, CA, RA, Digital Certificate, Digital Signature, Non-repudiation of Origin, Nonrepudiation of Receipt.
Service - Level Agreement
Security, Controls and Guidelines
Threats to Information System : i) Physical (Insiders / outsiders) ii) Viruses, Worms, Trojan horse, Malwares, Software bombs, Phishing, Spoofing, Spamming, denial of service attacks etc.
Information System Security Measures, Policy, controls, ISO, 17799, BS7799, IS4477, IS Audit, BCP / DRP, IT Act 2000, Basel guidelines for E-banking, Various RBI Committee Reports on Information Systems.
IT Service Delivery & Support : Service level management practices, Operations management - work load scheduling, network services management, Preventive maintenance, Systems performance monitoring process tools, techniques, Functionality of hardware, software, data base. Drafting of RFP, system specifications, SLAs, Capacity planning & monitoring, Change management processes / scheduled, emergency in configuration of production systems, application of patches, releases etc., Incident & problem management practices, System resiliency tools and techniques - fault tolerance, elimination of single point of failure, clustering.
Download this as PDF from the attachment below:


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You don't need to worry about the angles. It should be clear that "flips" around the side bisectors as well as 180 degree rotation about the center are motions of the rectangle. Since it is NOT a square, flips around the diagonals and 90 degree rotations about the center are NOT motions.
For the rhombus, flips about the diagonals are motions and flips about the side bisectors are not.


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Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
your express consent. For more information, please refer to our Privacy Policy.
Section of Neurobiology, Physiology & Behavior, University of California, Davis, Davis, CA
Address for correspondence: Sue C. Bodine, Ph.D., University of California, Davis, Section of Neurobiology, Physiology & Behavior, 196 Briggs Hall, One Shields Avenue, Davis, California 95616; E-mail: firstname.lastname@example.com.
Submitted for publication December 2005.
Accepted for publication May 2006.
Skeletal muscle size is dynamic and responsive to extracellular signals such as mechanical load, neural activity, hormones, growth factors, and cytokines. The signaling pathways responsible for regulating cell size in adult skeletal muscle under growth and atrophy conditions are poorly understood. However, recent evidence suggests a role for the PI3K/Akt/mTOR pathway. Protein translation is regulated through the phosphorylation of initiation factors that are controlled by signaling pathways downstream of PI3K/Akt. Recent work in mammals has suggested that activation of Akt/PKB, a Ser-Thr phosphatidylinositol-regulated kinase, and its downstream targets, glycogen synthase kinase-3 (GSK3) and the mammalian target of rapamycin (mTOR), may be critical regulators of postnatal cell size in multiple organ systems, including skeletal muscle. This paper will review some of the recent data that demonstrate the critical role of Akt/mTOR signaling in the regulation of postnatal muscle size, especially under conditions of increased external loading.
It is well established that chronic loading and resistance exercise lead to increases in muscle fiber size and tension output (2,22,41,45). The cellular and molecular mechanisms responsible for signaling muscle growth in response to increases in external load are poorly understood. However, recent studies suggest that activation of the Akt/mTOR signaling pathways plays a critical role in the regulation of skeletal muscle size, especially under conditions of altered external loading (5-7,18,33,37). The target of rapamycin (TOR) is a highly conserved protein kinase that integrates signals from nutrients and growth factors to regulate cell growth (an increase in cell mass and size) and cell cycle progression (14,19). Although mTOR is best known as a regulator of cell cycle progression and cell proliferation, recent data have highlighted its important role in the regulation of cell growth (15,34). The purpose of this paper is to summarize some of the evidence supporting the hypothesis that adaptive muscle growth is dependent on the activation of mTOR, a Ser/Thr protein kinase, and its downstream targets, the ribosomal protein S6 kinase (S6K1/p70s6k) and the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1/PHAS-I).
Skeletal muscle growth occurs when the balance between protein synthesis and degradation shifts toward protein synthesis. Protein synthesis is known to increase under conditions of increased loading and during the recovery phase after resistance exercise (24,41,52). Increases in protein synthesis occur before an increase in RNA and DNA levels (52) and can be explained in part by an increase in the initiation of mRNA translation, a key regulatory step in protein synthesis. The initiation of protein translation requires the assembly of a translationally competent ribosome at the AUG start site near the 5-end of the mRNA (24). Protein translation can be controlled at two key steps: 1) modulation of the binding of the initiator methionyl-tRNA (met-tRNAi) to the 40S ribosomal subunit to form the 43S preinitiation complex, and 2) the binding of the mRNA to the 43S preinitiation complex to form the 48S preinitiation complex. Regulation of these translation initiation steps is controlled through the phosphorylation of initiation factors and protein kinases that are controlled by signaling pathways downstream of phosphatidylinositol 3-kinase (PI3K) (24,40).
Recent work in mammals has suggested that activation of PKB/Akt, a Ser-Thr phosphatidylinositol-regulated kinase, and its downstream targets, glycogen synthase kinase (GSK3) and the mammalian target of rapamycin (mTOR), may be critical regulators of postnatal cell size in multiple organ systems, including skeletal and cardiac muscle (Fig. 1) (14,24,39). Akt signaling promotes protein synthesis in a number of ways. For example, Akt phosphorylation of GSK3 leads to its inhibition and an increase in global protein synthesis through an increase in the activity of eurakyotic initiation factor 2B (eIF2B) (24). eIF2B is a guanine nucleotide exchange factor that mediates the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2). The active eIF2-GTP binds to met-tRNAi, which then binds to the 40S ribosomal subunit. In addition, Akt can phosphorylate mTOR, which, in turn, leads to phosphorylation of p70s6k and 4E-BP1/PHAS-I (14,19). Phosphorylation and activation of p70s6k lead to hyperphosphorylation of the ribosomal protein S6, which is associated with enhanced translation of a specific class of mRNAs that contain a 5-terminal oligopyramidine structure. Proteins encoded by such mRNAs include the ribosomal proteins and elongation factors. Phosphorylation of the translational repressor 4E-BP1 leads to its release from within an inhibitory complex with the translation initiation factor 4E (eIF4E). eIF4E is the rate-limiting translation initiation factor that binds to the cap structure at the 5-end of mRNA transcripts to initiate cap-dependent translation. Release of eIF4E from 4E-BP1 permits eIF4E to bind to the scaffolding protein eIF4G, which then binds to the cap structure of the mRNA and assembles the eIF4F initiation complex by recruiting other initiation factors.
The growth of an organ is mediated by increases in both cell size and cell number. Genetic studies in drosophilas and mice have clearly demonstrated that the PI3K and TOR pathways are important regulators of cell and organ growth. In drosophilas, inactivation of PI3K, chico (insulin-receptor substrate (IRS) ortholog), PDK1, Akt, TOR, and S6K decreases organ and cell size, whereas overexpression of many of these molecules increases organ and cell size (35,51). Inactivation of PI3K results in a reduction in organ size through a decrease in both cell size and number, and inactivation of S6K reduces organ size through a decrease in cell size only (51). In mice, homozygous deletion of IRS-1, Akt1, or S6K1 results in a small animal phenotype (11,29,49). In the S6K1 knockout mice, skeletal muscle mass is reduced by a decrease in fiber cross-sectional area, with no decrease in the number of myonuclei per fiber (34). Furthermore, modulation of PI3K, PDK1, or Akt expression in the heart affects heart size as a result of changes in cardiomyocyte size but not cell number (28,39).
The activation of mTOR-mediated pathways seems to be critical for normal postnatal growth of mammalian skeletal muscle, but it is not required for the maintenance of muscle mass. The phosphorylation state of p70s6k is elevated in skeletal muscle of early postnatal versus young adult rats (Fig. 2A). The relative importance of mTOR in the control of early postnatal muscle growth was demonstrated by treating growing rat pups with rapamycin, a selective inhibitor of mTOR. Rapamycin binds to its intracellular receptor, FKBP12, forming a complex that binds mTOR with high affinity and blocks its ability to phosphorylate its downstream targets (19). Delivery of rapamycin (1.5 mg·kg−1·d−1 intraperitoneally) to 2-wk-old rat pups for 11 d resulted in a 30% reduction in body weight in both male and female pups (Fig. 2B). Interestingly, the effects of rapamycin on muscle growth were reduced as the rats developed into young adults. Fourteen days of rapamycin treatment beginning at 2 wk of age resulted in a 40% decrease in hindlimb muscle mass, and treatment beginning at 4 wk of age produced only a 20-25% decrease in muscle mass relative to untreated controls (Fig. 2C). Most surprising was the observation that rapamycin treatment in young adult rats (10-12 wk old) produced no change in muscle mass, suggesting that the maintenance of muscle mass under steady-state conditions is not dependent on the activation of mTOR pathways.
It should be noted that much of what is known about mTOR function has been inferred from experiments employing rapamycin. Rapamycin-dependent inhibition of mTOR decreases cell growth through inhibition of protein translation and ribosome biosynthesis (19). However, inhibition of mTOR with rapamycin can also decrease the rate of cell cycle progression and proliferation of mammalian cells in vitro for reasons not currently understood (15,34). The mechanism by which mTOR coordinates cell growth and cell cycle progression are currently unknown. The deletion of S6K1/2 genes in combination with the expression of a hypophosphorylated form of 4E-BP1 (which would bind eIF4E) is not sufficient to mimic the effect of rapamycin on cell proliferation (34). Consequently, mTOR must regulate cell proliferation through effectors other than S6K1/2 and 4E-BP1. It is not known whether there is a direct effect of rapamycin on the activation, proliferation, and/or fusion of satellite cells in vivo in skeletal muscle under growth conditions. Several studies have demonstrated that during hypertrophic growth of myotubes in vitro, there is an upregulation of the cell cycle gene, cyclin D1, and an increase in cyclin D1−dependent CDK4 activity (20,33). The upregulation of cell cycle genes, however, was not associated with an increase in the number of myonuclei per fiber. The activation of cell cycle regulators during hypertrophy may be controlling processes other than cell cycle progression, such as ribosome biosynthesis (33) or the transcription of specific genes (20).
Protein kinase B/Akt activity increases in response to numerous stimuli, including a wide variety of growth factors and hormones (e.g., insulin-like growth factor-1 (IGF1) and insulin) (24,43). IGF1 binding to its receptor leads to the production of phosphatidylinositol 3,4,5-triphosphate, which leads to the recruitment of Akt from the cytosol to the membrane, where it becomes activated through the phosphorylation of Thr 308 and Ser 473 (36). Transgenic overexpression of IGF-1 from a muscle-specific promoter results in an enlargement in skeletal muscle size (12,48). Furthermore, IGF-1 given to C2C12 myotubes in vitro leads to an increase in cell size because of activation of the PI3k/Akt/mTOR signaling pathway (43). The IGF-1-induced growth of myotubes in culture is not the result of an increase in the number of myonuclei and can be inhibited by the coadministration of rapamycin (34,43).
To obtain evidence for a role of the Akt/mTOR pathway in regulating adaptive muscle hypertrophy in adult animals, the phosphorylation status of key protein kinases and initiation factors in the Akt/mTOR pathway were examined in the plantaris muscle of young adult female Sprague-Dawley rats after functional overload (compensatory hypertrophy). The plantaris was exposed to a chronic increase in activity and external loading after bilateral removal of its functional synergists, the soleus, and medial/lateral gastrocnemius muscles (6). The amount of Akt and, more importantly, the phosphorylation state representing activated Akt, increased throughout the hypertrophy process (from day 3 to 14) (Fig. 3A). After 14 d, the total amount of Akt had increased fourfold more than controls, and the level of phosphorylated/activated form increased ninefold in the hypertrophied plantaris. In addition, phosphorylation of mTOR on Ser 2448 increased twofold (42). Examination of the downstream targets of mTOR revealed an increase in the phosphorylation status and activity of p70S6K, as well as hyperphosphorylation of PHAS-1/4E-BP1 (Fig. 3B). Hyperphosphorylation of 4E-BP1 resulted in its release from eIF4E, allowing it to bind eIF4G, as demonstrated by a decrease in the amount of 4E-BP1:eIF4E complex and an increase in 4E-BP1:eIF4G complex (6,42).
These findings indicated that Akt and its downstream targets were activated in vivo during load-induced muscle hypertrophy. To determine whether activation of mTOR was necessary to produce muscle hypertrophy, rats subjected to functional overload were treated with rapamycin. Daily treatment with rapamycin (1.5 mg·kg−1 intraperitoneally) did not alter phosphorylation or activity of Akt itself or its mTOR-independent target GSK-3β, but it did specifically block the activation of targets known to be downstream of mTOR (6). Most importantly, rapamycin treatment led to a 95% reduction in plantaris growth relative to control at 7 and 14 d of functional overload, as assessed by both muscle mass (Fig. 4A) and fiber cross-sectional area (6). These data demonstrate that Akt and its downstream target, mTOR, were phosphorylated/activated during load-induced adapative muscle hypertrophy. Further, the finding that specific inhibition of mTOR with rapamycin resulted in a nearly complete blockage of growth suggests that the activation of mTOR and its targets, p70S6K and PHAS-1/4E-BP1, were necessary for adaptive hypertrophy.
The relative importance of p70S6K versus PHAS-1/4E-BP1 in the regulation of muscle fiber growth is unclear. Manipulation of S6K1, S6K2, 4E-BP1, and eIF4E levels in myotubes suggests that S6K1 is the primary regulator of muscle fiber size (34). However, another study (15) suggests that both S6K1 and 4EBP1/eIF4E can influence mammalian cell size. Increases in protein synthesis can be achieved by increasing protein translation through pathways that increase translation initiation and/or elongation, or through the addition of myonuclei. The extent to which each mechanism is required to produce growth in response to load is debated, and it may differ depending on the extent of the increase in cell size. It is well established that activation, proliferation, and fusion of satellite cells is critical for growth and repair after injuries that induce muscle degeneration (10). However, the role of satellite cells in adaptive hypertrophy and regrowth after atrophy is less clear. During compensatory hypertrophy it has been postulated that increases in protein synthesis are initially derived through increases in translational efficiency, followed later by changes in translational capacity through the addition of myonuclei. Indeed, increases have been found in the number of myonuclei/fiber after months of functional overload (3), and irradiation studies suggest that satellite cell incorporation is critical for compensatory hypertrophy of the rat EDL and plantaris muscles (1,44). However, irradiation results in the loss of all proliferating cells, including satellite cells, and may interfere with the activation of protein synthesis pathways (1). For example, Adams et al. (1) demonstrated that the rat plantaris is capable of early muscle growth (15 d) after irradiation and functional overload, whereas the later growth is blocked, suggesting the need for myonuclei addition (1). However, in those overloaded plantaris muscles exposed to irradiation, there was a decrease in p70s6k and 4E-BP1 phosphorylation, relative to overloaded nonirradiated, which could impact protein synthesis (1).
Functional overload represents a very specific model of altered use and external loading. To determine whether activation of Akt/mTOR signaling pathways represented a general response to increased loading, the response of muscle to reloading after disuse muscle atrophy was examined. Fourteen days of hindlimb suspension (HLS) in young adult female Sprague-Dawley rats resulted in a 15-55% loss of mass in various lower-limb muscles (Fig. 4B). On release from suspension, the atrophied hindlimb muscles experience a chronic increase in external loading and hypertrophy, achieving a 15-20% recovery in muscle mass after 7 d of reloading (Fig. 4B). The exception was the tibialis anterior muscle, which showed a 4% decrease in muscle mass during the first 7 d of recovery. Hindlimb unloading of the medial gastrocnemius resulted in a decrease in the phosphorylation state of Akt, as measured by phospho-specific antibodies (Fig. 3C). Further, there was a 60% decrease in phosphorylation of mTOR on Ser 2448, with no change in total protein (42). Consistent with the changes in Akt and mTOR activation, there was a decrease in the activation state of p70S6K and an increase in the amount of 4E-BP1 bound to eIF4E (6). These changes reverted on reloading of the muscle (Fig. 3C).
As in the functional overload model, treatment with rapamycin during the reloading period resulted in a significant block of muscle growth (Fig. 4B). The inhibition of growth by rapamycin varied across the muscle types and was less complete in the HLS/reloading model compared with the functional overload model. This suggests that muscle growth after atrophy differs from functional overload in that it requires the activation of mTOR and additional signaling pathways. One possible candidate is the GSK3/eIF2 pathway, which was inhibited during HLS and activated during reloading (data not shown). Another protein that was modified during HLS was elongation factor 2 (eEF2). eEF2 is regulated through the mTOR pathway and by cellular energy stress status (9) and mediates the translocation step of elongation. Phosphorylation of eEF2 at Thr 56 inhibits its activity by preventing binding to the ribosome. After HLS, eEF2 phosphorylation increased immediately (day 1) and remained elevated relative to control for at least 7 d (data not shown). Phosphorylation of eEF2 is catalyzed by eEF2kinase, the activity of which is also inhibited by phosphorylation. Recent studies have reported that eEF2 kinase is phosphorylated by p70s6k and p90RSK1, suggesting control not only by mTOR pathways but also by MAP kinase pathways (8,9).
Muscle growth occurs in response to increases in mechanical loading and also in response to selective chemical agents, such as the β2-adrenergic agonist, clenbuterol (21,30). The mechanism by which clenbuterol induces muscle growth is unclear, although increases in protein synthesis have been measured after clenbuterol treatment (21). The phosphorylation status of p70s6k and PHAS-1/4E-BP1 is elevated in the rat plantaris (50) and the medial gastrocnemius (unpublished data) after daily clenbuterol treatment. Further, a role for mTOR in mediating the effects of clenbuterol was demonstrated by the ability of rapamycin to inhibit muscle growth during clenbuterol treatment. Clenbuterol (3 mg·kg−1 subcutaneously) treatment produced a 30-35% increase in the mass of the medial gastrocnemius and tibialis anterior muscles, whereas coadministration of clenbuterol and rapamycin (1.5 mg·kg−1 intraperitoneally) treatment produced no significant muscle growth (Fig. 5). These data suggest that clenbuterol-induced muscle growth is mediated through the activation of mTOR and its downstream targets. The inhibition of clenbuterol-induced growth by rapamycin is most likely the result of blocking protein synthesis and not satellite cell proliferation/fusion, because satellite cell fusion into myofibers has not been observed during clenbuterol-induced hypertrophy (31).
The above data demonstrate that the Akt/mTOR pathway is activated in, and requisite for, muscle hypertrophy. To demonstrate that activation of Akt/mTOR is sufficient to induce muscle hypertrophy, constitutively activate Akt (c.a.Akt) has been overexpressed in skeletal muscle using two methods: plasmid injection and electroporation of individual muscles in adult animals (6,37), and transgenic overexpression (27). Overexpression of c.a.Akt in skeletal muscles results in an increase in muscle fiber size (6,27,37). Further, the effects of c.a.Akt can be blocked by the concurrent administration of rapamycin (6,37), demonstrating that the growth of muscle fibers in response to c.a.Akt is mediated through the activation of mTOR and its downstream targets.
Finally, are the effects of resistance exercise mediated through the Akt/mTOR pathway? The first evidence that mTOR and its downstream targets could have a role in mediating the effects of resistance exercise came from a study by Barr and Esser (5). In this study, p70s6k phosphorylation was shown to increase in the tibialis anterior and extensor digitorum longus muscles at 3 and 6 h after an acute bout of lengthening contractions produced by high-frequency neural stimulation. More interesting was the observation that there was a direct correlation (r = 0.998) between the increase in p70s6k measured at 6 h after an acute exercise bout and the percent change in muscle mass measured after 6 wk of training (5). These data suggested that p70s6k activation was involved in the adaptive growth response to chronic resistance exercise. However, no studies to date have examined the activation of Akt and its downstream targets during chronic resistance exercise training in vivo.
An increase in the phosphorylation of Akt, mTOR, and GSK3 is detected in isolated rat muscles immediately after high-frequency stimulation (4). Further, activation of the translational regulators p70s6k, 4E-BP1, eIF2B, and eEF2 is observed at 3 h poststimulation (4). The best in vivo support for a role of mTOR signaling in resistance exercise, however, comes from the work of Kubica et al. (25,26). In these studies, male Sprague-Dawley rats were trained to perform repetitive ankle extensions with a 0.6-g weighted vest. In this model, protein synthesis and polysomal aggregation were shown to significantly increase in the medial gastrocnemius at 16 h postexercise. The status of ribosomal assembly can be assessed from the separation of muscle extracts on a sucrose gradient where polysomes migrate to the denser fractions and monosomes remain in the less dense fractions. A shift in the distribution of ribosomes from monosomes to polysomes is interpreted as an increase in protein translation. The increase in protein synthesis and polysomal aggregation observed after the acute resistance exercise was completely prevented with the administration of rapamycin 2 h before the exercise. At 16 h postexercise, a small but significant increase in p70s6k and 4E-BP1 phosphorylation relative to sedentary controls was measured. Interestingly, although there was an increase in S6 phosphorylation, there was no detectable change in the amount of 4E-BP1 bound to eIF4E or eIF4G. Of particular interest was the finding that the increase in eIF2Bε protein expression after resistance exercise was rapamycin dependent, suggesting that mTOR activation was responsible for the early increase in eIF2Bε translation.
These data and others (5,18,32,38) provide strong support for the hypothesis that mTOR signaling is a critical mediator of muscle growth after resistance training. Although the majority of studies have examined acute exercise from muscles that have experienced lengthening contractions, muscle hypertrophy can occur in response to isometric and shortening contractions as demonstrated by Adams et al. (2). The extent to which mTOR and its downstream targets are activated under all types of muscle contractions remains to be determined. Additional pathways may also be important in signaling protein synthesis after both acute and chronic resistance exercise. For example, activation of MAPK (17,39) and GSK3 (46) pathways have been measured after mechanical loading, which could enhance protein synthesis.
The present literature supports a role for the activation of Akt/mTOR signaling pathways in regulating muscle growth through an increase in protein synthesis. However, the mechanisms regulating muscle fiber size are complex, and the relative contribution of changes in translation efficiency and/or addition of myonuclei to adaptive hypertrophy require further study. The use of rapamycin has greatly increased our understanding of the role of mTOR in regulating muscle growth. However, the generation of mice with muscle-specific conditional deletions and overexpression of mTOR, S6K1, 4E-BP1, and eIF4E would assist in defining the specific function of mTOR and its downstream targets in muscle growth under varying conditions. The relative contribution of mTOR pathways in regulating load-induced fiber growth in normal versus atrophied muscles is unclear and needs further investigation. For example, whereas activation of mTOR and its downstream pathways seem to be critical for muscle growth after functional overload (6), "regrowth" of muscle after atrophy may rely on mTOR as well as additional pathways (6,16). Cell growth (an increase in cell size or mass) is tightly coupled to nutrient availability, growth factors, and the energy status of the cell (13,23). mTOR is capable of integrating signals from all of these inputs in the regulation of protein translation and cell growth. The extent to which any or all of these signals are involved in regulating the activity of mTOR during mechanical loading requires further investigation. It is interesting to note that Akt activation occurs after low-intensity, long-duration contractions, which are typically associated with endurance-type training, with no activation of mTOR and its downstream targets (47). The upstream effectors responsible for the selective activation of Akt and mTOR signaling after increases in activity and load are unknown. Potential upstream effectors include growth factors, insulin, integrins, G protein-coupled receptors, and amino acids. Our knowledge of the mechanisms that regulate muscle fiber size has grown considerably in recent years. However, additional research is needed to identify the critical signaling pathways that translate external signals into changes in muscle size. A better understanding of the cellular pathways regulating skeletal muscle size should assist in the development of treatments for muscle disorders.
All animal work was done in accordance with guidelines set by the Institutional Animal Care and Use Committee. I would like to thank my colleagues at Regeneron Pharmaceuticals, Inc. and the University of California, Davis for their support and expertise.
This article has been cited 6 time(s).
©2006The American College of Sports Medicine
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The day that Handsome came home with a large empty furnace box I thought he had lost his mind. He just plopped it in the living room and left it there. I was already too tired from the day to bother bugging him about bringing it home and having to cut it up so we could recycle it. I just left it and went about doing my dinner preparations.
I was pretty busy but every once in a while I could hear them getting into it, and there was giggling and some screeches of excitement. I though. "ok, maybe the girls like it" I could not have been more wrong.
The girls were ecstatic! I looked around for Handsome and could not find him. He was in the box. He had gotten some crayons and was in the box with the girls. They were colouring and he was colouring. He was deep in the box. The girls would then pop our of the box and close the "door" and run around the box and pop back in. Handsome was colouring a "mural" inside the box of our whole family. It was so much fun. I couldn't help but want to climb in there, and I did. All week we played in that box until it started to fall apart and we needed to throw it away.


text: 106 goals by I Am Endurance Best Sellers Trending Art Best Selling Paintings Best Selling Abstract Art Prints Best Selling Photography Best Selling Posters Popular Subjects Animals Architecture Childrens Art Floral & Still Life Landscape Maps Military & War Music Science Fiction & Fantasy Skylines Spiritual Transportation Featured Artists Brickhut Cozamia Eric Joyner Erin Ashley James Niehues Jennifer Lommers Jonas Gerard Marcia Baldwin Mark Lawrence Michael Creese Michael Tompsett Collections ArtLoversOnline Design Pics The Fine Art Masters Panoramic Images Retro Images Archive StockTrek Images WorldWide Archive Create Your Own Photo Canvas Custom Frame Photos goals by I Am Endurance Sign inCustomer Service Cart Houzz Share on Tumblr Tweet +Add to Cart Available Sizes inches / cm Petite $57.50 Small $69.00 Medium $86.25 Large $115.00 Grande $230.00 Massive $345.00 » component prices Print Frame Mats Glazing Fitting Customize Framing or choose Canvas Print Customize Canvas or choose Framed Art Print Click to save as artist's preferred kit Paper Enhanced MattePremium Photo GlossyPremium Photo LusterUltraSmooth Fine ArtHahnemuhle Photo Rag 308Hahnemuhle Fine Art PearlHahnemuhle Torchon Mounted? ★★★☆☆ Details Paper print only, too large to frame online. Frames Choose a color » ø Top Mat | Middle Mat | Bottom Mat ø Glazing Style Soft EdgeWhite EdgeBlack EdgeImage WrapUnstretched 1½ inches thick (3.75 cm) Product Details Artist grade canvas, archival inks, wooden stretcher bars, and UVB protective coating Availablity Usually ships within five business days. Artist I Am EnduranceCollection IAmEndurance Popular Configurations Stretched Canvas Modern Lines Contemporary White Classical Baroque Unframed print Explore More from the same collection View All I Am Endurance's Recent Work About the artist I Am Endurance Member Since February 2012 Artist Statement To see people attempt extraordinary things, things seemingly beyond themselves, resonates with us on a primal level. We are moved and inspired. Whether they triumph or fail is almost beyond the point and both teach us valuable lessons. We mostly admire the courage and tenacity it takes in the attempt and hope that when the time comes we can rise to the occasion.However, to endure would have very little meaning without the connections we have and make, the values we embrace and the passions, contradictions and aspirations we possess. At our worst we can be base and petty, cold, calculating and indifferent. But at our best we are noble creatures, inspired and inspiring and full of hope. We are flames of light that pierce the void and we should never forget it no matter what may befall us.I hope you like the work and hope in the times and tests ahead laughter, friendship and strength will sustain you while a belief in yourself and the best of what we can be and achieve will prevail and endure.- I am Endurance Community Comments Catalog Details Product No 4379769 Subjects Style Medium Tags Endurance, I am Create Frame Photos Photos on Canvas Sell Sell Art Online Become an Affiliate Get a Trade Account Common Questions Company Info About Us Contact Customer Comments Return Policy Social Tumblr Pinterest Twitter Facebook Instagram Our Wall Art Family CanvasOnDemand | Photo Canvases GreatBigCanvas | Decorate Huge Terms of Service Privacy Policy Copyright © 2016


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With more than 41,000 gifts from alumni, friends, faculty, staff, parents and community partners, The Campaign for SDSU now totals more than $400 million, marking the strongest period of fundraising in San Diego State University's history. SDSU's first-ever comprehensive fundraising campaign was launched as a way to create new opportunities for student success and to help SDSU continue to develop as a leading public research university. The gift that pushed the campaign past this milestone was a $250,000 donation by Union Bank to SDSU's Guardian Scholars program, which provides foster youth, as well as those who have been homeless, with a comprehensive, holistic support program to help them achieve the goal of a college degree.
"We are thrilled to be able to support San Diego State in reaching this milestone," said Mary Curran, executive vice president of Union Bank and SDSU alumnus. "The campaign really energizes people, providing resources that help to enrich student lives and develop future leaders. At Union Bank, we believe a great way to invest in our community and into a strong and vibrant San Diego, is by giving to San Diego State."
Launched in 2007, the campaign has benefited from 76 gifts of $1 million or more. It has included more than $200 million for SDSU's eight colleges to establish faculty endowments and support academic programming. Another $55 million in gifts support students through scholarships, internships and research opportunities.
"Crossing the $400 million milestone is a tribute to the extraordinary generosity of our alumni and community supporters," said SDSU President Elliot Hirshman. "The campaign has already had a transformational effect on our campus and there is great momentum as we advance to our goal of $500 million. My deepest appreciation goes to all of the members of our campus community who have helped the campaign move forward."
SDSU faculty and staff have also been pillars of the campaign, contributing nearly 10 percent of the total raised so far.New resourcesIn the last year alone, The Campaign for SDSU has announced:
Building the endowmentDonor generosity has also enabled San Diego State to build its endowment, defined as philanthropic gifts of cash and securities invested to support future academic programs, faculty research and student scholarships. More than 100 newly endowed faculty positions, academic programs and student scholarships have been established in the last five years."The importance of a healthy endowment cannot be overstated," said Kit Sickels, chair of the Campanile Foundation. "The best universities have large endowments that allow them to move to the next level of excellence and provide transformational education for future generations of students."Best and brightest Raising funds for student scholarships was a priority of The Campaign for SDSU from the very beginning. Strong donor support for this initiative has resulted in more than $55 million in new scholarship funding, and university remains committed to providing financial help for qualified students who cannot afford college tuition and fees. Additionally, the campaign makes it possible for SDSU to offer more scholarships to students at the top of their high school classes based on GPA and SAT scores. Many of these "best and brightest" students will be invited to apply to the University Honors Program, which is set to expand its numbers and programming thanks to campaign funds."Receiving a best and brightest scholarship has allowed me to stay local, caring for my mother who was diagnosed with breast cancer," said Kristin Bala, a first-year student majoring in cellular and molecular biology. Bala's goal is to become a physician in San Diego, aiding the local community. "I am so appreciative of the donors and the opportunities their philanthropy has provided," she said.Supporting excellenceClosely aligned with the campaign is a new strategic plan for SDSU, Building on Excellence, which establishes the direction and priorities of the university for the next 36-48 months. The plan is the culmination of a months-long, consultative process involving students, faculty, staff, alumni and the San Diego community. Through specific initiatives spelled out in the plan and supported by campaign funds, SDSU will advance student success, accelerate research and creative endeavors and enlarge its role as a center of community life and engagement. Alumni engagement As the campaign moves to within striking distance of its $500-million goal, the university is urging all SDSU alumni to become part of its success. "Every Aztec, Any Amount, Every Year" is our call to SDSU's nearly 280,000 alumni," said Mary Ruth Carleton, vice president for University Relations and Development. "The success of The Campaign for SDSU will be measured not only in dollars raised, but also in the commitment of every alumnus to building a stronger university for future Aztecs." To learn more about The Campaign for SDSU, visit sdsu.edu/campaign.
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BALTIMORE — The passes were sharp, the defense sound and the goals plentiful.
The United States couldn't have played much better, and the timing could not have been more perfect.
Clarence Goodson and Joe Corona scored during an eight-minute span of the first half, and the U.S. cruised past El Salvador 5-1 yesterday to advance to the semifinals of the CONCACAF Gold Cup.
Eddie Johnson, Landon Donovan and Mix Diskerud added second-half goals for the Americans, who will next play on Wednesday in Dallas against Honduras, a 1-0 winner over Costa Rica.
Assists aren't an official statistic in the Gold Cup, but Donovan set up three scores.
"I think Landon proved again today how valuable he is and now he can make a difference," coach Jurgen Klinsmann said. "This game was important for coaches to see who is a difference maker. Overall, we see our team clicking more and playing better and better."
The U.S. has won nine straight full internationals — a record for the country's national team. The Americans have also prevailed in seven of their past eight Gold Cup matches.
"We are trying to catch up with the big teams in the world," Klinsmann said. "It's all about speed. I'm not talking about physical speed. I'm talking about mental speed, passing speed with every player going both ways. That's what we're working to. This is a process and I think that process is coming along."
Rodolfo Zelaya scored for El Salvador, 1-19-7 overall against the U.S."Collectively, they're a very good team," El Salvador coach Agustin Castillo said through a translator. "They almost play by memory. They can find the spaces. It almost seems like every time they pass the ball into a space it's going to nobody, then somebody appears and actually meets the ball."


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Valuing Women. Working for Change.Our primary goal is to create a supportive, comfortable environment for our clients. Our small staff consists of one Coordinator and three Employment Counsellors, and we offer individual counselling by appointment at our office, as well as workshops in various locations throughout HRM. (Keep an eye out for our Fall, Winter, and Spring workshop schedules!) In addition to counselling and workshops, we provide daily computer access for job seekers, as well as a job board filled with recent postings. WEO accepts job postings from various employers in the Halifax Regional Municipality.
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