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Clostridium botulinum
Clostridium botulinum is a Gram-positive, rod shaped bacterium that produces the neurotoxin botulin, which causes flaccid muscular paralysis seen in botulism, and is also the main paralytic agent in botox. It is an anaerobic spore-former, which produces oval, subterminal endospores and is commonly found in soil.
Clostridium botulinumis a rod-shaped microorganism. It is an obligate anaerobe, meaning that oxygen is poisonous to the cells. However, they tolerate very small traces of oxygen due to the enzyme called superoxide dismutase (SOD) which is an important antioxidant defense in nearly all cells exposed to oxygen. [1] Clostridium botulinum does not form endospores as a way to protect the viability of the organism, but rather as a mechanism to produce the neurotoxin. Clostridium botulinum is only able to produce the neurotoxin during the process of producing the endospore and this can only happen in an anaerobic environment. Other microbiological organisms produce spores in an unfavorable growth environment to preserve the organism's viability and permit survival in a dormant state until such time the spores are exposed to conditions that can support their growth. An example of how botulisum could occur, would be as a result of improperly preserved or home canned low acid vegetables that were not processed using correct preservation times and or pressure. As an added precaution, Clostridium botulinum endospore production enables the organism to produce the potent neurotoxin, and therefore all home-canned vegetables and meats should be boiled without tasting for 10 minutes plus one minute per 1,000 feet above sea level (15 minutes at 5,000 feet). Boil home-canned spinach and corn 20 minutes before tasting. If the food looks spoiled, foams or has an off odor during heating, do not eat, discard and decontaminate any surfaces the food may have touched.
In the laboratory Clostridium botulinum is usually isolated in tryptose sulfite cycloserine (TSC) growth media, always in an anaerobic environment with less than 2% of oxygen. This can be achieved by several commercial kits that use a chemical reaction to replace O2 with CO2 (E.J. GasPak System). C. botulinum is lipase negative microorganism, it grows between pH values of 4.8 and 7 and it can't use lactose as a primary carbon source, characteristics important during a biochemical identification.[2]
Taxonomy history
Clostridium botulinum was first recognized and isolated in 1896 by Emile van Ermengem from home cured ham implicated in a botulism outbreak.[3] The isolate was originally named Bacillus botulinus. However, isolates from subsequent outbreaks were always found to be anaerobic spore formers, so Bengston proposed that the organism be placed into the genus Clostridium as the Bacillus genus was restricted to aerobic spore-forming rods.[4]
Since 1953 all species producing the botulinum neurotoxins (types A-G) have been designated C. botulinum. Substantial phenotypic and genotypic evidence exists to demonstrate heterogeneity within the species. This has led to the reclassification of C. botulinum type G strains as a new species Clostridium argentinense.[5]
Clostridium botulinum strains that do not produce a botulin toxin are referred to as Clostridium sporogenes.[6]
The complete genome of C. botulinum has been sequenced Sanger.
The current nomenclature for C. botulinum recognises four physiological groups (I-IV). This is mostly based on the ability of the organism to digest complex proteins.[7][8] Studies at the DNA and rRNA level support the subdivision of the species into groups I-IV. Most outbreaks of human botulism are caused by group I (proteolytic) or II (non-proteolytic) C. botulinum. Group III organisms mainly cause diseases in animals. There has been no record of Group IV C. botulinum causing human or animal disease.
Neurotoxin types
Neurotoxin production is the unifying feature of the species C. botulinum. Seven types of toxins have been identified and allocated a letter (A-G). Most strains produce one type of neurotoxin but strains producing multiple toxins has been described. Clostridium botulinum producing B and F toxin types have been isolated from human botulism cases in New Mexico and California.[9] The toxin type has been designated Bf as the type B toxin was found in excess to the type F. Similarly, strains producing Ab and Af toxins have been reported. There is evidence that the neurotoxin genes have been the subject of horizontal transfer, possibly from a viral source. This theory is supported by the presence of integration sites flanking the toxin in some strains of C. botulinum. However, these integrations sites are degraded indicating that the C. botulinum acquired the toxin genes quite far into the evolutionary past.
Only types A, B, E, and F cause disease in humans while types C and D cause disease in cows, birds, and other animals but not in humans. The "gold standard" for determining toxin type is a mouse bioassay, but the genes for types A, B, E, and F can now be readily differentiated using real-time PCR.[10]
Organisms genetically as they identified as other Clostridium species have caused human botulism; Clostridium butyricum producing type E toxin[11] and Clostridium baratii producing type F toxin.[12][13] The ability of C. botulinum to naturally transfer neurotoxin genes to other clostridia is concerning, especially in the food industry where preservation systems are designed to destroy or inhibit only C. botulinum but not other Clostridium species.
|Group I
|Group II
|Group III
|Group IV
|Toxin Types
|Disease host
|Toxin gene
|Close relatives
|C. sporogenes, C. putrificum
|C. butyricum, C. beijerinickii
|C. haemolyticum, C. novyi type A
|C. subterminale, C. haemolyticum
Clostridium botulinum in different geographical locations
A number of quantitative surveys for C. botulinum spores in the environment have suggested a prevalence of specific toxin types in given geographic areas, which remain unexplained.
North America
Type A C. botulinum predominates the soil samples from the western regions while type B is the major type found in eastern areas.[14] The type B organisms were of the proteolytic type I. Sediments from the Great Lake regions were surveyed after outbreaks of botulism among commercially reared fish and only type E spores were detected.[15][16][17] It has been noted in a survey that type A strains were isolated from soils that were neutral to alkaline (average pH 7.5) while type B strains were isolated from slightly acidic soils (average pH 6.25).
Clostridium botulinum type E is prevalent in aquatic sediments in Norway and Sweden,[18] Denmark,[19] the Netherlands, the Baltic coast of Poland and Russia.[14] It was then suggested that the type E C. botulinum is a true aquatic organism and this was shown by the correlation between the level of type E contamination and flooding of the land with seawater. As the land dried, the level of type E decreased and type B became dominant.
In soil and sediment from the United Kingdom, C. botulinum type B predominates. In general, the incidence is usually lower in soil than in sediment. In Italy, a survey was conducted in the vicinity of Rome, and a low level of contamination was found; all strains were proteolytic C. botulinum type A or B.[20]
Clostridium botulinum type A was found to be present in soil samples from mountain areas of Victoria.[21] Type B organisms were detected in marine mud from Tasmania.[22] Type A C. botulinum have been found in Sydney suburbs and types A and B were isolated from urban areas. In a well defined area of the Darling-Downs region of Queensland, a study showed the prevalence and persistence of C. botulinum type B after many cases of botulism in horses.
A "mouse protection" or "mouse bioassay" test determines the type of C. botulinum present using monoclonal antibodies. This can now also be accomplished using real-time PCR.[23]
Clostridium botulinum is also used to prepare the medicaments Botox, Dysport, Xeomin, and Neurobloc used to selectively paralyze muscles to temporarily relieve muscle function. It has other "off-label" medical purposes, such as treating severe facial pain, such as that caused by trigeminal neuralgia.
Botulin toxin produced by Clostridium botulinum is often believed to be a potential bioweapon as it is so potent that it takes about 75 nanograms to kill a person (LD50 of 1ng/kg,[24] assuming an average person weighs ~75kg); 500 grams of it would be enough to kill half of the entire human population.
Clostridium botulinum is a soil bacterium. The spores can survive in most environments and are very hard to kill. They can survive the temperature of boiling water at sea level, thus many foods are canned with a pressurized boil that achieves an even higher temperature, sufficient to kill the spores.
Growth of the bacterium can be prevented by high acidity, high ratio of dissolved sugar, high levels of oxygen, very low levels of moisture or storage at temperatures below 38°F (type A). For example in a low acid, canned vegetable such as green beans that are not heated hot enough to kill the spores (i.e., a pressurized environment) may provide an oxygen free medium for the spores to grow and produce the toxin. On the other hand, pickles are sufficiently acidic to prevent growth; even if the spores are present, they pose no danger to the consumer. Honey, corn syrup, and other sweeteners may contain spores but the spores cannot grow in a highly concentrated sugar solution; however, when a sweetener is diluted in the low oxygen, low acid digestive system of an infant, the spores can grow and produce toxin. As soon as infants begin eating solid food, the digestive juices become too acidic for the bacterium to grow.
- ^ Doyle, Michael P. (2007). Food Microbiology: Fundamentals and Frontiers. ASM Press.
- ^ . (2005). Brock Biology of Microorganisms (11th ed.). Prentice Hall. ISBN 0131443291.
- ^ E. van Ergmengem. 1897. Über einen neuen anaeroben Bacillus und seine Beziehungen Zum Botulismus. Zentralbl. Hyg. Infektionskr. 26:1–8.
- ^ I. A. Bengston. 1924. Studies on organisms concerned as causative factors in botulism. Hyg. Lab. Bull. 136:101
- ^ J. C. Suen, C. L. Hatheway, A. G. Steigerwalt, D. J. Brenner. 1988, Clostridium argentinense sp.nov.: a genetically homogeneous group composed of all strains of Clostridium botulinum type G and some nontoxigenic strains previously identified as Clostridium subterminale or Clostridium hastiforme. Int. J. Sys. Bacteriol. 38:375–381.
- ^ Judicial Commission of the International Committee on Systematic Bacteriology (1999) Rejection of Clostridium putrificum and conservation of Clostridium botulinum and Clostridium sporogenes Opinion 69. International Journal of Systematic Bacteriology. 49:339.
- ^ L. V. Holdeman, J. B. Brooks. 1970. Variation among strains of Clostridium botulinum and related clostridia. Protocols of the first U.S-Japan conference on Toxic Microorganisms. pp. 278–286
- ^ L. D. S. Smith, G. Hobbs. 1974. Genus III Clostridium Prazmowski 1880, 23. In R. E. Buchanan, N. E. gibbons (eds.), Bergey's Manual of Determinative Bacteriology, 8th edition. William & Wilkins, Baltimore. pp. 551–572.
- ^ C. L. Hatheway, L. M. McCroskey. 1987. Examination of faeces for diagnosis of infant botulism in 336 patients. J. Clin. Microbiol. 25:2334–2338.
- ^ Satterfield, B. A., Stewart, A. F., Lew, C. S., Pickett, D. O., Cohen, M. N., Moore, E. A., Luedtke, P. F., O'Neill, K. L. & Robison, R. A. (2010). A quadruplex real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F. J Med Microbiol 59, 55-64.
- ^ P. Aureli, L. Fenicia, B. Pasolini, M. Gianfrancesche, J. M. Mccroskey, C. L. Hatheway. 1986. Two cases of type E infant botulism caused by neurotoxigenic Clostridium botulinum in Italy. J. Infect. Dis. 154:207–211.
- ^ J. D. Hall, L. M. McCroskey, B. J. Pincomb, C. L. Hatheway. 1985. Isolation of an organism resembling Clostridium baratii which produces a type F botulinal toxin from an infant with botulism. J. Clin. Microbiol. 21:654–655.
- ^ S. Notermans, A. H. Havellar. 1980. Removal and inactivation of botulinum toxin during production of drinking water from surface water. Antonie van Leeuwenhoek 46:511–514.
- ^ a b A. H. W. Hauschild. 1989. Clostridium botulinum. In M. P. Doyle (ed.), Food-borne Bacterial Pathogens. Marcel Dekker, New York. Pp. 111–189
- ^ T. L. Bott, J. Johnson, E. M. Foster, H. Sugiyama. 1968. Possible origin of the fish incidences of Clostridium botulinum type E in an inland bay (Green Bay of Lake Michigan). J. Bacteriol. 95:1542.
- ^ M. W. Eklund, M. E. Peterson, F. T. Poysky, L. W. Peck, J. F. Conrad. 1982. Botulism in juvenile Coho salmon (Onocorhynchus kisutch) in the United States. Aquaculture 27:1–11
- ^ M. W. Eklund, F. T. Poysky M. E. Peterson, L. W. Peck, Brunson. 1984. Type E botulism in salmonids and conditions contributing to outbreaks. Aquaculture 41:293–309.
- ^ A. Johannsen. 1963. Clostridium botulinum in Sweden and the adjacent waters. J. Appl. Bacteriol. 26:43–47.
- ^ H. H. Huss 1980. Distribution of Clostridium botulinum. Appl. Environ. Microbiol. 39:764–769.
- ^ R. Creti, J. Fenicia, P. Aureli. 1990. Occurrence of Clostridium botulinum in the soil of the vicinity of Rome. Curr. Microbiol. 20:317.
- ^ C. E. Eales, J. M. Gillespie. 1947. the isolation of Clostridium botulinum type A from Victorian soils. Aust. J. Sci. 10:20–21.
- ^ D. f. Ohye, W. J. Scott. 1957. Studies in the physiology of Clostridium botulinum type E. Aust. L. Biol. Sci. 10:85–94.
- ^ Satterfield, B. A., Stewart, A. F., Lew, C. S., Pickett, D. O., Cohen, M. N., Moore, E. A., Luedtke, P. F., O'Neill, K. L. & Robison, R. A. (2010). A quadruplex real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F. J Med Microbiol 59, 55-64.
- ^ By Diane O. Fleming, Debra Long Hunt. Biological Safety: principles and practices. ASM Press, 2000, p. 267.


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BURLINGTON, Wash. -- Thrifty Foods here has agreed to purchase Consumers Choice, Bellingham, Wash., for an undisclosed sum. > The acquisition, which is expected to be completed Oct. 1, would boost Thrifty to 24 stores with annual sales of more than $300 million. McCown De Leeuw & Co., a private venture-banking firm based in Menlo Park, Calif., acquired Thrifty Foods in a leveraged buyout in March. Thrifty operated 12 stores at the time. Thrifty purchased two stores in Olympia, ...
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Current Events
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Bruno Lends His Support To Fashion-Challenged 'Yes On 8' Rally
In Pershing Square yesterday, Defamer stood alongside fellow Californians waging war against the evil Prop 8, hoisting placards and cheering wildly as passing vehicles (including city buses and cop cars) honked their support for equal civil rights for all. Meanwhile, at a Yes on 8 rally outside City Hall, none other than Austrian fashion journalist and trendspotter Brüno had infiltrated the scene. (Amazingly, The Sun once again reports he was there to shoot footage for "Brüno: Delicious Journeys Through America for the Purpose of Making Heterosexual Males Visibly Uncomfortable in the Presence of a Gay Foreigner in a Mesh T-Shirt," our own parody title that simply refuses to die.) People reports that once Sacha Baron Cohen was discovered, his "own camera crew worked to shield him. Eventually, he was escorted away inside a van"—the suspiciously swishy hunter became the hunted! We salute what must have been an incredibly difficult decision for Bruno to wear Dockers, a Men's Warehouse shirt, and no hair product in order to blend with the unfabulous crowd more efficiently. More photos after the jump:
[Photo credit: AP]


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I don't understand what question 1 is asking for.
2. To find a maximum velocity you need to solve
for t and show that you have a maximum at that t.
3. Do they really mean average acceleration or rate of acceleration I wonder? By the mean value theorem, the average rate of acceleration is
(By the way, the time rate of change of acceleration is called a "jerk.")
4. The instantaneous rate of acceleration is da/dt.


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Friday, April 5, 2013
Royal resigns
For more, click here.
8 comments:
- Exit 0 said...
Why resign if they have "no evidence?"
- April 5, 2013 at 12:30 PM
One of the commenters on the article linked to states that owners were terrorized and harassed. This was SOP with Royal and her boys. I'm glad to see someone else saying it.
If charges are not forthcoming, then the county government, including the commissioners, have lost all credibility. So she was allowed to resign? What does that mean? She can resign in lieu of being fired? That does not mitigate criminal acts. She was the person who was supposed to be enforcing animal law. If she, in fact, broke it and other laws, she is an even bigger offender.
The message here is clear. You, the taxpayer offend, and you will be held to the letter of the law. One of us in the county government gets caught offending, oops, not so much. We're above the law. It's a slippery slope, isn't it folks?
And heaven help those who point it out. Let's ask who has been spoken to about her and helped cover up the cat litter thus far. Ron Smith, Tracy Jackson, and even Bill Pope. These "gentlemen" need to explain their roles in this. Chris Royal's boys need to be examined for their behavior. I'd be turning that agency inside out and they wouldn't be able to sneeze without getting their britches checked.
It's time, folks. It's your money.
- April 5, 2013 at 4:47 PM
If there has been no wrong doing, why resign?
- April 5, 2013 at 6:59 PM
Regarding the comments below the article, I know of a number of people who were indeed threatened and harassed and if they did not voluntarily surrender their animals, they would be arrested. Her officers were very good at doing this and sometimes she did it herself. I saw it personally. It was blatant, bald-faced extortion. They'd come in, go out to the truck and call her. Then they'd come back in and say, you have too many dogs or cats or this one is too old or that one looks sick. If you don't give us those, we'll take 'em all. Then they'd take them and put them right to sleep. I know because a rescue went right up after some of the animals one person was forced to turn in. She had her a real reign of terror going. I agree, a grand jury should be convened as someone said in another place on this blog. If this is the mentality she put in place, it's not leaving with her. Look at the news report on TV a month or so ago about a so-called dangerous dog. That was all her doing and that was not a lone case. This woman clearly hated animals. Anyone who says otherwise is deluding themselves.
- April 6, 2013 at 2:30 PM
There are educational requirements. I personally saw the posting under which she was hired. It stated, quite clearly that two years of veterinary science or equivalent was required, an associate degree, and failing that, a similar degree in business administration. If she was hired without those things, then the county failed the taxpayers and the animals. Facility services to animal control is a stretch and on the job training in such a vital job is not exactly something that can be defended by the county.
As for resigning because of controversy, really? If this was the sole reason, why not put her somewhere else? What isn't Ron Smith telling us?
Saying that there is going to be a "once over" in the shelter is not going to cut it. She brought in a culture of doing things her way if the above post is any indication (2:30) and clearly there are people there who operated under her tutelage. I don't know if everyone there should remain or not.
Working with vets and rescues is a positive step and should have been done all along. Local shelters in other areas that work hand in hand with rescues have substantially lower euthanization rates and there is much more public education about spaying and neutering. The Newmans have a low cost spay and neuter clinic in Mooresville. There are, and always have been, available options here for the shelter to reach out to and work with. These would certainly save the county money in the overall scheme of things.
Ron Smith shares some of the blame in this. He had been brought multiple complaints against her and chose to side with her over and over. We are the taxpayers and we are the customers. The customer is never wrong. It's time Mr. Smith learn that. He always adopted the attitude that angry people made up things about his people. Look where it's gotten this county.
I hope he knows that we are keeping an eye on him as well. It will be a long time before this is forgiven. It's going to take some time for this county to heal. Resigning isn't enough. We want a full and thorough investigation and a once over isn't going to cut it. Pets are family and she has hurt our families.
And yes, Mr. Smith, there are state laws that regulate shelters. You would be well served to look into this.
- April 6, 2013 at 4:12 PM
Regarding Mr. Smith's comment in the article about educational requirement's, here is the original posting from when Ms. Royal was hired.
DUTIES: Performs managerial, supervisory and specialized work in directing and supervising the activities of the animal services program for Iredell County. Work involves supervising office support and kennel employees as well as employees involved in capturing, confining, and humanely euthanizing stray, diseased, and dangerous/nuisance animals; supervising the maintenance of all records and reports related to animal services programs and activities; overseeing the low-cost spay/neuter program; and enforcing animal ordinances. The Animal Services Manager also develops and implements departmental policies and procedures; recommends the departmental budget and ensures funds are spent within approved line items; directs departmental purchases and related accounting procedures; and resolves citizen complaints, working with boards to settle grievances. This position requires initiative and independent judgment in all phases of work as well as tact and courtesy in frequent contact with animal owners and the general public. Reports to the Assistant County Manager.
MINIMUM EDUCATION AND EXPERIENCE REQUIRED: Associates degree in business administration, veterinary science, or related field and 2 years experience, including 1 year in an administrative/supervisory role; or graduation from high school and 4 years related experience including 2 years in an administrative/supervisory role; or any equivalent combination of training and experience which provides the required skills, knowledge and abilities.
SPECIAL REQUIREMENTS: Possession of a valid North Carolina driver's license; euthanasia and chemical immobilization certification and completion of a Cruelty Investigators course within one year of employment; and knowledge of the use and care of firearms, tranquilizer guns, and other related equipment.
SALARY RANGE: $37,110.00 – $57,557.83 Grade 70
APPLICATION DEADLINE: February 16, 2007
Submit an Iredell County Application to Iredell County Human Resources, P O Box 788, Statesville, NC 28687-0788. Applications can be obtained from Human Resources by calling 704-878-3000 or downloaded from the web at www.co.iredell.nc.us.
Iredell County does not discriminate on the basis of race, color, national origin, sex, religion, age or disability in employment or the provision of services.
Posted: 01/26/07
Furthermore, there are state laws regulating shelters. It would behoove Mr. Smith to become familiar with these as well. Give the shelter a "once over" isn't going to cut it but working with vets and rescues is a step in the right direction.
The community needs to heal. This is going to take some time. I'd suggest the community be brought in and their concerns listened to. Rescues are a great asset and educate the public. Mooresville has a low cost spay and neuter clinic. The need to euthanize goes down as the community is invested in the shelter and keeping the population down. This can be turned around and become an asset to the county.
- April 7, 2013 at 12:07 PM
I love how she says that no evidence was found that she didn't do any unauthorized euthanizations. How is it she was privy to the investigation and its findings? Was she walking around behind those doing the investigating? Lookee here, Chrissie, you got caught. There is plenty of evidence out there that you embezzled, that you probably can be accused of grand theft or larceny. Let's just hope you get some criminal charges to go along with your resignation. You are not a popular person right now and you never were. You never will be. If I were you, I'd move far, far away after I got out of prison. If there is any justice, you'll be convicted of animal cruelty and not be allowed to have animals again. Ever. Goodbye horsies. Goodbye bronco bulls. Too bad, so sad. Karma, she's a bee-otch, ain't she?
- April 7, 2013 at 3:29 PM
There are three dogs on Clay Street "crying" and barking day and night? This has gone on for several months. I have called the police, but was told that unless the cops, themselves, hear the dogs it is considered an unfounded complaint. At first the barking and crying were just annoying, but now I am concerned for the dogs. There are three of them tied up in the yard, but I cannot tell if they have adequate water, shelter, etc. I don't know who to call or what to do. Can you help? (Don't use my name, please.) I left the people a nice note about a month ago, but it hasn't done much good.
- October 7, 2013 at 4:55 PM


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i dont know why i cant post it the correct way
From now on, try using the built in feature we have in the forums. Use the \frac{}{} command w/in the math tags. i.e. [tex]\frac{x^2-2x+1}{x^2-4x+4}[/tex] gives us . You can learn more about this code in the LaTeX Help Forum.


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Clinical Research Associate (CRA II or Senior CRA) – Small and friendly CRO – UK
- Employer
- Meet Recruitment
- Location
- UK – field/office based (South East/London/Kent office option)
- Salary
- £30k-40k + benefits
- Posted
- Feb 18, 2013
- Closes
- Mar 18, 2013
- Ref
- Discipline
- Clinical, Clinical Research, Clinical Trials, Other, Research, Life Sciences, Biotechnology, Cancer Research/Oncology, Cardiology
- Result Type
- Jobs
- Position Type
- Permanent
- Hours
- Full Time
Clinical Research Associate (CRA II/Senior CRA): This small CRO has a global presence and is rapidly expanding over the next 18 months. They are currently looking for an experienced CRA II/Senior CRA to add to their team in their London offices, although those with enough experience are able to work home based. This is an exciting time to join this close-knit organisation as a CRA as there is lots of opportunity to learn and progress with your career.
The client is a global CRO which prides itself on the relationships that it has built worldwide. Following a strong 2011 they are looking to continue their expansion, with a particular emphasis on their European offices. They offer a stimulating and supportive work environment where CRAs can cover a range of Phases from I to IV in cardiovascular, endocrine/metabolic, and oncology.
As a CRA you will have many responsibilities, among them:
· Conducting pre-study, initiation, monitoring, and closeout visits for research sites;
· Acting as a site manager and solution provider;
· Identifying investigative sites for new studies;
· Completing visit reports and maintaining study-related databases.
The ideal candidate will have:
· CRA experience – 2 years+
· Experience in oncology, diabetes, and cardiovascular disease preferred;
· Bachelor or Master of Science in a health related field or equivalent;
· Ability to understand and present relevant clinical and pre-clinical topics;
· Ability to travel – Full UK driving licence.
Commutable locations: UK – field/office based (South East/London/Kent office option)
Salary: £30k-40k + benefits
Full job description and company details are available upon application, apply below. This position is being dealt with by Yasmin Dyer at meet, call on + 44 203 178 7488 or email directly at email@example.com to discuss in confidence.
Find out more about us at www.peoplewithchemistry.com
Associated keywords: CRA, Clinical research associate, Senior CRA, Snr CRA, CRA II, leadership, mentoring, development, CRO, UK, England, South East, London, Kent, Office, Home based, Field based, CRA, Clinical research associate, Snr CRA, CRA II, leadership, mentoring, development, CRO, CRA


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65 Nanny Jobs Found
FT Nanny Needed for 5 yo & 8 mo Boys
Posted by Carol L. on 12/4/2016
- 20 miles away (Richmond, TX)
- $10/hr
- 2 children
I'm on the hunt for a trustworthy, flexible, and reliable nanny for my boys. They're easy to watch and they get along well with all of their babysitters. I'm currently interviewing for the best candidate to join our family as our FT Nanny. Please message me if you have interest in an interview. More
Nanny day care for a 6 month old baby
Posted by Sharath M. on 12/4/2016
- 21 miles away (Sugar Land, TX)
- $15/hr
- 2 children
Nanny day care for a 6 month old baby for 9 hours. Not much house work in scope. Baby care is the primary need. Looking for someone with ecperience.
Childcare provider
Posted by Amanda O. on 12/2/2016
- 24 miles away (Humble, TX)
- $12/hr
- 1 child
Taking care of our daughter while we are away at work (Week 1: Mon: 1-9 pm, Wed: 9 am to 9 pm and Week 2: Monday 8-5), which includes preparing her meals, changing her diaper and teaching her material to quickly develop.
Extended hours before and after school...
Posted by Danna B. on 12/1/2016
- 15 miles away (Pearland, TX)
- $10/hr
- 1 child
A loving mother of a highly-functional autistic 8 yrs old female, seeking care that involves extended before and after school care with transportation to/from school, 1-3 times a week. For the first six months of this assignment (while I work days), I would prefer my childcare needs to be provided... More
Posted by Ashley M. on 12/1/2016
- 15 miles away (Humble, TX)
- $15/hr
- 4 children
Need help picking kids up from school and watching them until Husband gets home. Approximately 3 hours a day. Kids ages are 7, 6, 4 & 4
Nanny for 5 month old
Posted by Karishma S. on 12/1/2016
- 21 miles away (Sugar Land, TX)
- $10–20/hr
- 1 child
Need a nanny to help care for baby. Some light housework and laundry will be assigned. Willingness to do some Cooking during free time is a big plus.
3 days a week nanny for an active 10 month...
Posted by Katrina Z. on 12/1/2016
- 15 miles away (Pearland, TX)
- $10–15/hr
- 1 child
We are looking for a nanny for our active 10-month old boy, to start in January, 2017. He will be 10 months old by January.) Will be needed 3 days a week from 7am to 6pm. Must be reliable and have experience with babies and toddlers. Please have two to three excellent references, paid babysitting... More
PT Nanny Needed For Infant
Posted by Lauren L. on 11/29/2016
- 8 miles away (Houston, TX)
- $12/hr
- 1 child
A mother's helper needed to help w/ infant: play, feed, watch, change infant. Take infant on walks and to attend playdates. Able to perform light housework, including laundry. Able to run errands to grocery store, etc. Open to walking two small house trained dogs.
Overnight Sitter
Posted by Sandra G. on 11/28/2016
- 21 miles away (Houston, TX)
- $100/week
- 2 children
Hi, I'm looking for an overnight sitter that can come to my house and watch my girls or that I can drop off to their home. I'm willing to pay $200 every two weeks. I'm a single mom with 2 little girls they're 1 and 3 years old. I work Sunday-Thursday 10pm-7am. I leave my home at 9:20pm and usually... More
Fun family!
Posted by Rachel B. on 11/28/2016
- 16 miles away (Bammel, TX)
- $10/hr
- 4 children
Fun family seeks fun caregiver. Care not needed immediately, but sometime next year. Four children learn through play, discovery, and self-guided projects.
Live-In Nanny Needed
Posted by Amber P. on 11/28/2016
- 9 miles away (Houston, TX)
- $10–20/hr
- 1 child
I am looking for a live in nanny to care for a 12 year old. He will need to be driven to and from school and occasional extracurricular activities. Light housekeeping, meal prep, possible running errands, taking care of the home. Please respond with your qualifications and pay requirements. I am... More
Afterschool care needed
Posted by Leena B. on 11/28/2016
- 15 miles away (Pearland, TX)
- $12–14/hr
- 3 children
I need someone to pick up my kids from school, help with homework and some light household chores like laundry, emptying dishwasher, cleaning up after kids
Nanny With Very Flexible Schedule Needed...
Posted by Sonya V. on 11/28/2016
- 19 miles away (Friendswood, TX)
- $10/hr
- 2 children
Please message inquiries to 832-723-7832. Current hours needed are listed below. We can add extra hours with house cleaning, errands, etc for the weeks with minimal childcare. On average it should be about 20 hours a week but will vary. There is a potential for additional coverage as my husband and... More
After school nanny for two boys
Posted by Nitika K. on 11/28/2016
- 21 miles away (Sugar Land, TX)
- $10–12/hr
- 2 children
Need someone trustworthy to take care of my two boys (11 years and 5 years) - need to pick them from school, take them to classes 2 to 3 times a week, house work, and laundry.
10 month old boy needs a sweet caregiver!
Posted by Devika R. on 11/28/2016
- 18 miles away (Houston, TX)
- $12/hr
- 2 children
Hi, I am in need of a care giver for my 10 month old son. I am a Nursing Director and work Monday through Friday from 9 to 4. I would need someone from 8am to 4pm. (My husband is usually home by 230-ish) I would like someone to come to my home to provide care for him. I would like someone who has... More


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Biggest Oscar Surprises Of The Last 10 Years... What's Next?
Every year, the Oscar nominations seem all sewn up. There are so many predictors – winners of critics' awards, Golden Globe nominees and winners, BAFTA nominees and the SAG nominees. Yet somehow, almost every year, a nominee slips in out of nowhere, and pundits shake their heads asking, "Where did that come from?"
This year's Oscar nominees will be announced next week, Jan. 25. We won't speculate yet, but there are bound to be some surprise nominees, even to the pundits.
Let's take a look back at the last 10 years and look at what was particularly surprising among the major Oscar nominees. Are there any patterns? Are any of these people or movies particularly well-liked? How did they defy the odds?
The biggest shocker this year was that director Steven Soderbergh was nominated twice for Best Director for both 'Erin Brockovich' and 'Traffic' (he would go on to win for 'Traffic'). This was the first time one person was nominated for Best Director in the same year since 1938, when Michael Curtiz was heralded for both 'Angels With Dirty Faces' and 'Four Daughters.' Ironically, these are still Soderbergh's only Best Director nominations.
Ethan Hawke rode Denzel Washington's coattails to a surprise Best Supporting Actor nomination for 'Training Day.' Washington would win Best Actor, becoming only the second African-American to claim that prize after Sidney Poitier. The same year, Halle Berry claimed Best Actress for 'Monster's Ball,' making her the first African-American woman to win Best Actress. Also that year, Sean Penn was a bit of a surprise in the Best Actor category for 'I Am Sam.'
This was a fairly predictable year, but Salma Hayek of 'Frida' managed to beat out Meryl Streep's praised performance in 'The Hours' for Best Actress. Streep took solace, though, in nabbing a Best Supporting Actress nomination for 'Adaptation.'
Some predicted it, but it was still surreal to hear Johnny Depp's name read off as a Best Actor nominee for 'Pirates of the Caribbean: Curse of the Black Pearl.' The same year, Keisha Castle-Hughes surprised everybody by pulling off a Best Actress nomination for 'Whale Rider' at age 13 – the youngest Best Actress nominee ever - when she was expected as a Best Supporting Actress nominee. But Academy members decide where to place people. In addition, both Samantha Morton as Best Actress and Djimon Hounsou as Best Supporting Actor were honored for the little-seen 'In America.'
The biggest omission of the year was Paul Giamatti being dissed for his widely praised performance in 'Sideways' – which netted nominations for both Thomas Haden Church and Virginia Madsen. Who bumped him out of the Best Actor race? Most likely Clint Eastwood for 'Million Dollar Baby.' Eastwood was seen as a likely nominee for Best Director of the same film (he went on to win) but an acting nomination was considered a long shot. Giamatti was rewarded the following year with a Best Supporting Actor nomination for 'Cinderella Man.'
Steven Spielberg's 'Munich' did surprisingly well this year, as did 'Hustle & Flow,' which not only nabbed little-known Terrence Howard a Best Actor nomination, but it ended up winning Best Song. William Hurt also turned heads by being nominated for a ten-minute performance at the end of 'A History of Violence,' one of the shortest nominated performances in Oscar history.
Clint Eastwood surprised again by nabbing 'Letters From Iwo Jima' both Best Picture and Best Director slots, even though the year's buzz surrounded its companion movie, 'Flags of Our Fathers.' Ryan Gosling of 'Half Nelson' also came out of left field with a Best Actor nomination, while Mark Wahlberg of 'The Departed' nabbed a Best Supporting Actor nomination for a fairly small role – besting co-star Jack Nicholson, who had a much showier part.
'In the Valley of Elah' peaked early with Oscar buzz, then died quickly. Tommy Lee Jones' Best Actor nomination for that film was a surprising show of praise from the Academy. Laura Linney also defied the odds by being nominated for Best Actress for the little-seen 'The Savages,' also starring Philip Seymour Hoffman, who got snubbed.
While 'The Reader' got good reviews, no one expected it to pick up several Oscar nominations, including for Best Picture and Best Director Stephen Daldry. Kate Winslet also made headlines by grabbing a nomination for Best Actress – she had been promoted as Best Supporting Actress for 'The Reader' with hopes of scoring a Best Actress nomination for 'Revolutionary Road.' She went on to win Best Actress anyway. The same year, Richard Jenkins, a well-known character actor, rose above the ranks to get a Best Actor nomination for 'The Visitor,' while Michael Shannon, widely praised as the mentally unstable neighbor in 'Revolutionary Road,' scored that film's sole major nomination.
In retrospect, 'The Hurt Locker''s success with the Academy all but guaranteed a Best Actor nomination for Jeremy Renner, but at the time he was hardly a shoo-in. But easily the biggest "out of nowhere" nomination of the year was courtesy of Maggie Gyllenhaal, nominated as Best Supporting Actress for 'Crazy Heart.' She had shown up on no major awards lists, and beat out stars such as Julianne Moore for 'A Single Man.'
As for 2010, what do you think? Who will be the surprise nominees? We'll find out next week.


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I watched the film again after about 5 years, and while back than it seemed a bit childish to me, the way those two people were talking and kind of blocking themselves, I must say I liked it much more this time around. I didn't notice some of the great filmmaking the first time around, and particularly the last 20 minutes and the ending are outstanding.
Instead of a review (you know why ) here's the poem from the gorgeous looking street bum which he writes for and reads to Celine and Jesse in the film.
Daydream delusion
Limousine eyelash
Oh, baby, with your pretty face
Drop a tear in my wineglass
Look at those big eyes
See what you mean to me
Sweet cakes and milkshakes
I am a delusion angel
Im a fantasy parade
I want you to know what I think
Dont want you to guess anymore
You have no idea where I came from
We have no idea where were going
Lodged in life, like branches in the river
Flowing downstream
Caught in the current
I carry you, youll carry me
Thats how it could be
Dont you know me?
Dont you know me by now?


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Bryan Petersen
Bryan Evan Petersen (twitter: @Peteypipes)
Positions: Outfielder and Pinch Hitter
Born: April 9, 1986 in Agoura Hills, CA
High School: Chatsworth HS (Chatsworth, CA)
School: University of California, Irvine (Irvine, CA)
Drafted by the Florida Marlins in the 4th round of the 2007 amateur draft.
Signed June 26, 2007. (All Transactions)
Debut: May 7, 2010 (Age 24.028, 17,334th in MLB history) vs. WSN 1 AB, 1 H, 0 HR, 0 RBI, 0 SB
Rookie Status: Exceeded rookie limits during 2011 season [*]
Teams (by GP): Marlins/MiamiMarlins 2010-2012
Agents: ISE Baseball [*]
Last Game: October 3, 2012 (Age 26.177) vs. NYM 5 AB, 2 H, 0 HR, 0 RBI, 0 SB
About biographical information
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Getting Results Since 2005With over 10 years of experience, we've established ourselves as a registered provider by the Criminal Records Bureau, now the Disclosure & Barring Service. Every day we deliver a top quality, industry-leading service. And our close-knit team is always fully up-to-date with all areas of the vetting industry, changing our practices to keep up with any new legislation or regulations.
CBS provides its service to the whole of the UK and internationally, allowing you to screen your current and future employees regardless of where you're situated. Thanks to our streamlined solutions, everything is completed online – drastically reducing processing and administration times, ensuring you receive results quickly and accurately.
So if you are an individual, company or organisation and are interested in running any level of check, click on the options to the right of this page. If you'd like to talk directly to one of our experienced team members call us today on 01443 799 900. We look forward to your call.


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My son Simon was born in April 2011 at an area hospital. Soon after delivery I started to notice some "red flags," like his breathing was a little fast, and at times his color did not look quite right. These red flags continued when we were discharged from the hospital, and Simon began feeding poorly and looking blue. Trying not to overreact, I took him to the pediatrician's office where he received a pulse oximetry screening, which measures the amount of oxygen in the blood, and found he had low oxygen levels.
We were transported by ambulance to Children's Hospital of Wisconsin where Simon was diagnosed with a congenital heart defect. He was Continue reading →


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Bridgecorp Limited : 1723
Bridgecorp Limited: Case No 1723
Bridgecorp Limited was placed into receivership on 2 July 2007 owing approximately 14,500 debenture holders approximately $459 million.
The principle activity of Bridgecorp Limited was the sourcing of funds, and lending, in relation to property financing transactions which were primarily funded through issuing secured debentures to members of the public.
Rodney Petricevic, was the former Managing Director and majority shareholder in Bridgecorp. Robert Roest, was the former Finance Director, Chief Financial Controller for Bridgecorp and Secretary to the Board of Directors. Robert Roest is a former Chartered Accountant.
After considering a complaint received from PricewaterhouseCoopers, the Director determined that an investigation into the affairs of Bridgecorp Limited may disclose serious or complex fraud. An investigation under Part II of the Serious Fraud Office Act was commenced on 1 May 2008.
Progress of Investigation
March 2014
In respect to FMA charges in Bridgecorp: The FMA has consented to an $18.9 million settlement between the receiver of Bridgecorp, the Bridgecorp directors, and their liability insurers. FMA has agreed to end its own civil proceedings against the Bridgecorp directors once the settlement sum has been paid.
August 2012
The former Chief Financial Controller of Bridgecorp Limited, Robert Roest has also pleaded guilty in the Auckland District Court to one Crimes Act charge and two Companies Act charges brought against him by the Serious Fraud Office. He also entered guilty pleas to charges brought by the Inland Revenue Department relating to misapplication of PAYE deductions. Robert Roest has received an uplift of three months on his existing sentence of imprisonment of six and a half years, imposed in May, in respect of FMA convictions of various offences under the Securities Act, Crimes Act, and Companies Act.
July 2012
Rodney Petricevic has pleaded guilty in the Auckland District Court to two Crimes Act charges and two Companies Act charges brought against him by the Serious Fraud Office. He has received an uplift on his sentence of a further four months imprisonment in addition to his existing sentence of six and a half years in respect of earlier Financial Markets Authority (FMA) convictions in April this year.
February 2012
The three week trial originally set down for 5 March 2012 has been rescheduled to commence on 24 September 2012.
May 2011
Not guilty pleas have been entered and the case has been committed to trial. A trial date of 5 March 2012 has been set. The next appearance date is yet to be set.
September 2010
Rodney Petricevic and Robert Roest made a further appearance in the Auckland District Court on 27 September 2010. No pleas were entered. They are scheduled to next appear again in the Auckland District Court on 18 January 2011.
September 2010
The SFO filed formal written statements in the Auckland District Court on 6 September 2010. On 21 September 2010 the case was committed for trial.
May 2010
On completion of the investigations into a number of matters, final investigation reports were prepared for the Director. On the basis of these reports and following consultation with SFO Panel Counsel the Director decided to charge Rodney Petricevic and Robert Roest with offences under the Crimes Act.
Two charges were laid against Rodney Petricevic concerning his conduct in respect of a company called ABb. Due to the change in the law; these were charged in two distinct periods of time and under different sections – sections 220 & 227(ba) and then section 219.
Five charges under sections 220, 227(ba), 228, 229a(b), were laid against Rodney Petricevic and Robert Roest concerning the acquisition of the vessel 'Medici'.
The accused were summonsed and made their first appearance in the Auckland District Court on 28 June 2010.
The senior investigator for this case is Brett Beattie. If you have questions regarding your personal involvement with this case or information that may assist the investigation, he can be contacted on firstname.lastname@example.com or 0800 109 800.
For media enquiries call 027 705 4550


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Katzenmoyer Arrested
By Jim Letizia • Mar 29, 2013
Franklin County Sheriff's deputies say former Ohio State linebacker Andy Katzenmoyer was arrested this morning.
The 35-year-old Katzenmoyer is scheduled to be arraigned tomorrow on a charge of violating a protection order this past Tuesday on the West side. Deputies have released no other details. The award-winning linebacker left Ohio State in his Junior year in 1998 and was drafted in the first round by the New England Patriots. He played in 24 games before sustaining a career-ending neck injury.


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Food Blog
Posted In
February 5, 2013
LINDA (nee Hirshenhorn) Feb. 3, 2013, of Elkins Park, PA. Beloved wife of 59 years to William Forman. Mother of Curt Forman and Sally Lieberman. Sister of the late Richard. Grandmother of Sarah, Eric, Pamela "PJ" and Marti. Services and Interment were private. Contributions in her memory be made to the Forman Campus of the Jack Barrack Hebrew Academy
JOSEPH LEVINE and SONS, INC


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Ray Seva
Maybe you're an armed forces veteran who owns a small business and would like help in expanding operations. Perhaps you're a veteran and are thinking of starting your own business — but you don't know where to start. Or maybe you're a service-disabled veteran who owns a business and you'd like to know more about federal laws making it easier for you to secure lucrative federal contracts.
These are some of the topics to be covered at a free Veteran Business Development Workshop on March 8 at the North American Wind Energy Research Center on the campus of Mesalands Community College in Tucumcari.
The workshop is sponsored by the New Mexico Department of Veterans' Services (NMDVS) along with the Veteran Business Outreach Center (VBOC), and the New Mexico Small Business Development Center Network (SBDC).
One in seven businesses in New Mexico is veteran-owned, according to NMDVS Veterans' Business Development Director Lloyd Calderon. And given the state of today's economy, they can use some help.
"At this workshop, business owners and potential owners will get some excellent advice on not only how to survive, but thrive," said Calderon. "We believe anyone who's served our country deserves to be served when they've finished their military service and start anew as private citizen business owners."
NMDVS, SBDC and VBOC representatives will present information about special low-interest business loans specifically for veterans, alternative financing, procurement technical assistance, and specific laws which sets a goal that 3 precent of all federal contracts be awarded to qualified businesses owned by service-disabled veterans.
"Federal contracts can be extremely lucrative," said NMDVS Cabinet Secretary-Designate Timothy Hale. "We want to educate our service-disabled, veteran-owned businesses about these laws, and let them know we're here to assist them with landing some of these contracts."
The Veteran Business Resource Center (VBRC) in Albuquerque was created by the NMDVS to assist veterans throughout New Mexico who own or want to start a business. It was the first such center in the nation created solely for assisting veterans, and has now been duplicated in other states. Since its creation in the summer of 2008, the VBRC has assisted 125 New Mexican veteran-owned companies secure more than $36 million in federal contracts.
The Tucumcari Veterans' Business Workshop is free for all veterans, but space is limited and registration is required. Call 575-461-4413, ext. 140 for registration and more information.


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2012 Fall Schedule
Performance: International Dance Company Hubbard Hall, 6:00 pm. Attend the Cultural Connections Leadership Conference and enjoy a performance by the International Dance Company.
11/1 – 11/3
Event: Cultural Connections Leadership Conference Hubbard Hall. The Cultural Connections Leadership Conference brings together students, faculty, and staff from various cultural backgrounds in order to empower them to become advocates for change in an increasingly diverse global society. CCLC provides engaging and intentional activities that serve as a catalyst for personal and professional growth, resulting in producing strong individuals and productive members of society. For more information contact Michelle Buggs at (940) 898-3679 or email@example.com. www.twu.edu/intercultural-services/conference-asp
Exhibit: Global Connections Through Dress Old Main Building, Fourth Floor. Fashion and Textiles will be displaying global dress from five different countries. Each Monday a new display case with a new country will made available for viewing by the university community at no charge. Displays will include general information about the country, apparel production within the country, and traditional dress worn within the country. The specific dates for each country are as follows:
Nov. 5: Pakistan
Nov. 12: Indonesia
Nov. 19: Mexico
Nov. 26: Brazil
Event: Annual Italian Night Dinner 5:00 pm. Fine Arts Building Foyer. Delta Phi Delta holds their annual scholarship fundraiser dinner. For ticket information visit www.twu.edu/visual-arts
Event: Chrysanthemum Tea 9:30 – 11:00 am. Hubbard Hall Banquet Room. This TWU tradition began in the early 1980's. The Chrysanthemum Tea recognizes the TWU international community and educates the community about various cultures.
Performance: "Dancing at Lughnasa" by Brian Friel Wednesday, 11/14 @ 8 p.m., Thursday, 11/15 @ 4 p.m., Friday, 11/16 @ 8 p.m., Saturday, 11/17 @ 2 p.m. & 8 p.m., Sunday, 11/18 @ 2 p.m. Redbud Theatre Complex. This memory play centers around five unmarried sisters as they make the most of their simple existence in rural Ireland in the 1930s. For more information visit www.twu.edu/drama .
Event: Music Recital: Music Building, Eberly Hall, 1:30 – 2:20 p.m. The Department of Music and the Global Connections Initiative invite the TWU campus community to attend a "Kundiman Song Recital" presented by the vocal studio of Dr. Nicki Cohen, Professor of Voice and Music Therapy and Coordinator of TWU Vocal Studies. A reception will immediately follow, with refreshments promising a delicious taste of Filipino food. "Kundiman" is a genre of traditional songs from the Philippines that were composed in the 19th and early 20th century. Originating among the Tagalog of Luzon, the songs are written in the Tagalog language and are lush and beautiful, truly an expression of their sentimental nature. Today, they are accepted as one of the genre of Philippine music, not only because of the intense feeling that the songs convey, but also because of the high degree of musical artistry to which the country's composers have elevated them. The musical form is parallel minor and major keys, in triple time, with verses each consisting of about 12 syllables. For additional information and preview of the Filipino serenades: http://tagaloglang.com/Filipino-Music/Tagalog-Love-Songs/kundiman-song.html
Event: Thanksgiving and Picnic Celebration with Global Interact Time TBA. Location TBA. Another program offered by TWU International Education Office and Global Interact is a taste of Thanksgiving. In conjunction with TWU and UNT, Global Interact provides TWU international students an opportunity to celebrate and experience an American Thanksgiving. The program includes a traditional turkey, dressing, an array of vegetables, breads, rolls and desserts. Members of the Global Interact prepare and serve the food for the event and act as host and hostess.
For additional information on Global Connections events, contact:
Global Connections
P.O. Box 425437
Denton, TX 76204-5437
940.898.3366 (Fax)
page last updated 2/25/2013 12:10 PM


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Java Tiny Gfx Library (JTGL) is a graphic fundation framework (a graphics/gaming api) that will allow easy deployment/porting of applications/games on many environments: J2SE,J2ME/MIDP(Nokia,Siemens,BlackBerry),SuperWaba(Palm,PPC,Symbian),ExEn,DoJa,etc..1 weekly downloads
JUMP Extension for Oracle JDeveloper
An extension for OracleJDeveloper to build JUMP Projects (Java User Module for Palm, hosted by sourceforge.net).1 weekly downloads
This is a Instant Messenger for mobile(j2me enabled), Currently Supporting Jabber protocol.1 weekly downloads
Mobile Vélib
This is an application to research a Vélib' station with available bikes or free parks. Includes maps to display the results and history handling. Uses kXML for XML parsing and Google Maps Mobile for geocoding, itinerary and maps generation.1 weekly downloads
A J2ME Weblog Client for mobile devices that allows you to post to your weblog from java-enabled devices. MobileBlogger allows you to connect with many weblog systems such as Blogger, Movable Type, pMachine, and more.1 weekly downloads
The core of NetStereo is the server, which runs on a computer with a sound card and plays music, primarily MP3s. What makes the NetStereo server special is that it accepts commands from remote clients. The clients are stateless and can be connected and di1 weekly downloads
Palm OS CRLib
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11-18-2009, 05:13 PM #1Web Hosting Master
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What would happen if a virus happened to find its way onto a cloud?
I just read one of the other threads about Microsoft losing t-mobiles sidekick backups and I began to wonder. What would happen if a virus managed to get into and attack a cloud? Is that possible..?█ NEPA Fiber
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11-18-2009, 05:44 PM #2Uptime Aficionado
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Your run of the mill virus, even if it affects a guest operating system hosted on a "cloud", will not be able to impact anything other than that guest.
Given how much different systems "talk to" each other in order to coordinate important functionality like failover and live-migration, though, it definitely seems possible that a highly-sophisticated attack could be devised to bring down an entire "cloud" in one fell swoop.
Fortunately, there are some pretty big brains working on defending against these types of attacks. Unfortunately, there are equally intelligent people on the other side of the issue.
In reality, the level of risk should end up being about the same as the level of risk inherent to any peice of software. The "cloud" community will see security updates, patches, and the occasional exploit.Ask me about CloudCentrum (coming soon) -- The complete, turn-key cloud software solution
11-22-2009, 04:19 PM #3Newbie
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most hosting is going to be cloud in the future if you ask me. i think shared hosting is going to be a thing of the past with vps so cheap now. but when clouds do go down i hear it's a complete headache. i was just reading what a host had to go through when one of their clouds went down with thousands of clients on it. ironic, when clouds in essence are suppose to be disaster proof with all the redundancy.
11-22-2009, 04:29 PM #4Newbie
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Virtual Clouds introduce an entire new set of issues and vulnerabilities. They are not PCI compliant and any sensitive information should not be stored on them. Here's an interesting paper on the subject.
11-22-2009, 04:37 PM #5Web Hosting Master
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It is very much depends of the Cloud platform and the type of infrastructure. It is impossible to say what would happen. I don't think how does the Microsoft cloud platform work, but I don't think it will be different from the way a standard Windows powered system acts when it is harmed by a virus.Host Color ★ Cloud Servers & Dedicated Hosting & European Infrastructure Hosting
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11-22-2009, 06:16 PM #6Uptime Aficionado
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I don't deny that there are some risks inherent to virtualization, but let's not get carried away and over-state the issue.
Last edited by e-Sensibility; 11-22-2009 at 06:21 PM.Ask me about CloudCentrum (coming soon) -- The complete, turn-key cloud software solution
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MVL advances to semi's
Final moments of MVL's 20 to 16 win over Sleepy Eye. MVL's junior Qb, Ryan Grunke rushed for 146 yards and scored two touchdowns for the Chargers. MVL improves to 4 and 5 and will …26 Oct 11
Section Football Tonight
Section Football tonight on KNUJ, SAM 107.3 and knuj.net. Section 2A football tonight on 860 AM KNUJ, the MVL Chargers travel to Sleepy Eye to take on the Indians. Kick off is at 7pm.Section 3A …25 Oct 11
Sport Headlines for 10/25/11
Section 2A Volleyball Results:Section 3A Volleyball Results:Tomahawk Cross Country Meet25 Oct 11
Section Volleyball Tonight
Section 2A volleyball serves up tonight around the area.24 Oct 11
Sport Headlines for 10/24/11
Section 2A Volleyball tonight: Cedar Mountain/Comfrey at ClevelandSleepy Eye at SpringfieldCathedral at MVL on 860 AM KNUJSESM at BLH/Stewart on SAM 107.3Loyola at TrumanJan/Wal/Pem at MadeliaMLGHEC at Alden/Conger All 7pm Starts Section 3A Volleyball Tonight: …24 Oct 11
Sport Headlines for 10/22/11
Section 2A Girls Soccer Result:St Peter 2 Mankato West 1(Championship) College Volleyball Results:Concordia 3 Gustavus 0Augsburg 3 St Olaf 0Bethel 3 St Catherine 0St Thomas 3 St Marys 0St Scholastica 3 Martin Luther 0Northland 3 …22 Oct 11
High School


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"Abertawe" Swansea by Balam
Swansea Travel Guide: 106 reviews and 293 photos
Swansea is Wales second most populated City and the third most populated county in Wales.
Swansea originally developed as a Viking trading post but the Romans were also in the area as archaeological finds show, other finds include items from the Stone Age, Bronze Age, and Iron Age. A Castle was founded by Henry de Beaumont in 1106 and further extended and rebuilt in Stone over the years. Now in ruins there is not much left but the remains have now been preserved and have been made into a feature in the town centre.
Whilst the city itself has a long history most of the city centre buildings are post war as most of its older buildings were destroyed by bombing during World War II and mostly within a 3 day period on the 19th, 20th and 21st of February 1941.
Reviews (2)
The Dylan Thomas Centre in Swansea (Situated within the Guild Hall) is certainly worth a quick look if you?re in town,... more travel advice
Swansea castle was first mentioned in 1116 as having been attacked by the Welsh, at this time tha castle was made of... more travel advice
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We are asked to find the rate at which the water is rising. So that is dy/dt if the height of the water is y. And so we base the y from the bottom of the inverted cone.
Imagine, or draw the figure on paper. Draw a vertical cross-section of an inverted cone that's supposed to be 10cm round at the top and 20 cm tall. So you have an isosceles triangle that is standing on its apex. Draw the altitude from the apex to the midpoint of the 10-cm base at the top. Now you have two congruent rigth triangles, any of which has:
---vertical leg = 20cm
---horizontal leg = 10/2 = 5cm.
Now draw a horizontal line, supposed to be the level of the water rising in the cone, somewhere below the top base. Again, you have another pair of congruent smaller right triangles, each of which has:
---vertical leg = y cm
---horizontal leg = x cm
Volume of the water, V = (pi/3)(x^2)y -------(1)
V is in terms of x and y. For simpler differentiation, we need to express V in terms of one variable only. Since we are interested on dy/dt, we choose V in terms of y only.
So we express x in terms of y.
In the large and small right triangles in the figure, by proportion,
x/y = 5/20
So, x = 5y/20 = y/4
Substitute that into (1),
V = (pi/3)[(y/4)^2]y
V = (pi/48)y^3 ---------(2)
To have dy/dt, we differentiate (2) with respect to time t,
dV/dt = [(pi/16)y^2](dy/dt) ----------(3)
Since dV/dt = 1 cu.cm/sec, and y = (20-5) = 15cm, then dy/dt at that instant is:
Plugging in all known values into (3),
1 = [(pi/16)(15^2)](dy/dt)
1 = (225pi/16)(dy/dt)
dy/dt = 16/(225pi) = 0.022635 cm/sec -------------answer.
Ooopppss, sorry, the radius at the top is 10cm. I thought I read 10-cm diameter.
Some changes on the computations above then.
x/y = 10/20
x = y/2
V = (pi/3)[(y/2)^2]y = (pi/12)y^3
dV/dt = [(pi/4)y^2](dy/dt)
1 = (pi/4)(225)(dy/dt)
dy/dt = 4/(225pi) = 0.005659 cm/sec ------------final answer.


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Ball State University's (BSU) College of Architecture and Planning (CAP) has launched its sixteenth bi-yearly international study tour open to students in all three academic departments, Architecture, Landscape Architecture, and Urban Planning. The program, initiated over thirty years ago, called "Polyark", has evolved over the years from shorter single residential base study abroad formats to its current form as a fifteen-week intense global study tour - now adding the term "World Tour". The students' course work is woven inextricably into the intense day-by-day itinerary visiting places, spaces, design professionals, buildings, gardens, and vernacular environments - urban, rural, and natural. With the "world" as the classroom and curious minds wrestling with sketchbooks, traditional drawing media, and a collective dedication for 'design' to actuate more sustainable environments - a rich learning environment soars. Daily observing, reacting, recording, reflecting, and design experimentation frame the learning mosaic of the World Tour3/Polyark17 (WT3/P17) study team.
This WT3/P17 study team is comprised of two graduate students of Architecture, one graduate student of Landscape Architecture, twenty-one upper-level undergraduate students of Architecture, nine upper-level undergraduate students of Landscape Architecture, and two faculty directors one from the CAP Architecture program and one from the CAP Landscape Architecture program (33 students; 2 faculty). The group is committed to a high standard of on-the-fly course work and is eager that any and all visitors utilize the "Feedback" link-button, to the left, to communicate ideas, impressions, and even constructive and positive critique of the course work examples reviewed herein.
To the many CAP alumni who participated in past "Polyark" study tours, we send our warmest regards and do hope you will enjoy peering into the unique set of design education experiences that this WT3/P17 group is encountering. To the current Spring Semester 2007 BSU community and especially the campus-based CAP students, faculty, and administration, the WT3/P17 team thanks each and every one of you for your support and your individual and collective "believing" for our maximum learning experience and our safe travel here, there, and back to you all! We are aware that we have been given a great privilege to represent BSU/CAP afar, and we will do our best to "include" each of you in our trek through this web site. Please take a few minutes each day or each week to review the coursework and "feedback" to us your impressions and helpful advice.
Finally, the WT3/P17 team expresses its greatest thanks to the synergistic "giving" - recognizing the supportive parents and family members, various philanthropic community organizations, the care-full CAP administration, the gracious "Polyark" alumni scholarship donors, and the partnering spirit of the
, in general. For without the collective and essential educational backing for and financial support to the participants, the WT3/P17 tour and educational mission would not have been enabled! Thank you, one and all!!!


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Senate Majority Leader Randy Richardville, R-Monroe, told reporters "Tell the Mackinac Center that, OK?" on Wednesday in announcing his support for legislation that would put public school teachers in Michigan hired after Jan. 1, 2013, into a defined-contribution 401(k)-style plan, according to The Detroit News.
"It's what most of the private sector is moving toward, it's what the Legislature has," Sen. Richardville told The News. "Just in general, we're trying to correct promises that were made that couldn't be kept by previous Legislatures."
Sen. Mark Jansen, R-Grand Rapids, plans to offer an amendment to Senate Bill 1040 to make the change, The News reported.
Stay Engaged
The Legislature made the same decision in 1997 for state employees, which a 2011 Mackinac Center study found had saved taxpayers up to $4.3 billion in unfunded pension liabilities.
Sen. Richardville noted that there would be "upfront costs" involved with such a change.
James Hohman, assistant director of fiscal policy, addressed how the Legislature could confront those costs in this recent study.
You can read more about the issue here, here and here.
Related Articles:
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Fixing Michigan's Budget-Killing School Employees' Pension Up in the Air
Most Michigan Teachers Leave Before Qualifying For a Pension
Despite Union Claims, School Pension System is in Trouble
School Budgets, Senate Pension Reforms Under Attack From Pension System
Soaring Pension Costs Breaking School Budgets, Crimping Teacher Pay


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Copiague Veterinarians
We invite you to explore the biographies of our doctors and learn more about them. Our doctors have a wide variety of backgrounds and interests.
Michele MauroMedical Director
Veterinary School: University of Florida
Dr. Mauro began working as a vet assistant in a prominent north shore animal hospital when she was 15 years old. She received her undergraduate degree from Cornell University. Upon graduation, Dr....
Read Full Biography
Mark BettsAssociate Veterinarian
Veterinary School: Ross University School of Veterinary Medicine
Southgate Animal Hospital welcomes, Dr. Mark Betts.
Dr. Betts is a Long Island native that grew up in Nassau County. After earning his bachelors in veterinary science from...
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text: Parenting Educators [Archive] - Mothering Forums Mothering Forums > Archives > Miscellaneous > Archives > Practitioner Database > Parenting Educators PDA : Parenting Educators Personal and Business Mediation mother needs help in custody case! How to become a parent educator? Attachment Parenting Telephone Counseling Parenting Classes aparentconnection.com Metro Denver vBulletin® Copyright ©2000-2016, Jelsoft Enterprises Ltd.


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On Saturday, September 11th, artists around the country will participate in Mumia 911, a National Day of Art to Stop the Execution of Mumia Abu Jamal. Tomorrow, artists will create and perform works, hold concerts, shows and exhibits, and dedicate their events to the award-winning death row journalist and political prisoner. Events and performances will be held in various parts of the country, in places such as Seattle, Boston, New York, Las Vegas and Hawaii, and in places around the world such as Berlin, Tasmania and Barcelona.
- Jessica Care Moore, poet and playwright, and founder of Moore Black Press.
- Danny Hoch, actor and solo performer. His three solo shows, "Pot Melting," "Some People," and "Jails, Hospitals & Hip-Hop" have toured over 50 cities to sold out houses.
Related links:


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The Dish
Tag: cheeseburger
The Triple Treat (some might call it The Triple Guilty Pleasure) at Del Frisco's Grille
- 1:34 pm Friday, May 30th, 2014 by M.M. Cloutier
Time was when, at least for high-school football players (including Burt Reynolds and ever-tanned George Hamilton) and their gals, the place to pile in or park along a flanking asphalt apron (with 40 cars three-deep) was The Hut along Flagler Drive in downtown West Palm Beach.
The Hut's long gone since its heyday in the 1950s (it opened in 1931 and, after various owners, closed in 1973, followed by a brief stint in 1977 and then its razing in 1982) and so too its 20-cent gooey cheeseburgers downed with a milkshake and an all-American glow the Saturday Evening Post couldn't resist featuring in its pages in 1946.
Here's a [More]
Gigi's Tap & Table, at 150 Worth, now open for dinner, too
- 8:24 pm Friday, November 22nd, 2013 by M.M. Cloutier
After debuting last month with lunch service, Gigi's Tap & Table—a Coniglio family-owned bistro and bar serving classic American fare (sometimes with a twist) on the second level of 150 Worth—is now open for dinner, too.
At the same time, lunch has been enhanced with a $12 combo at Gigi's (833-8800; www.gigspalmbeach.com), a casual place with indoor and outdoor tables, a billiards lounge, classic cocktails, draft beers and "snacks" (mixed olives, parmesan crisps and deviled eggs) for, say, mid-afternoon or late-night noshing.
What perhaps is telling is the spectrum of the top-selling dishes thus far: "Mayor's" meatloaf, all-American cheeseburger, wild-mushroom truffle [More]


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Green Environmental Health Sports
Registration deadline November 18, 2013. Spend Thanksgiving kayaking spring fed rivers, camping, and enjoying the coastline in search of the Florida manatees. No experience is necessary but participants should be comfortable with water and be able to attend a pre trip training session.
Sports Athletics
David Jones Memorial Classic - UH Women's Basketball vs. Prairie View


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By Janet Bresenham
PORTALES — Modern Christian ministry comes in many forms.
For one Portales church, outreach to the community is brewing in the form of a cup of coffee or tea.
Victory Life Church is celebrating a month-long grand opening of The Coffee House, which features a wide range of coffees, teas, iced drinks and pastries, along with live music and a variety of comfortable seating areas for conversation and relaxation.
"I just like the atmosphere," said ENMU sophomore Jeff Howard, a pre-med student. "It's very loving and very accepting. It's just a fun place to be, where you can talk to people."
The Coffee House officially opened for business on April 3 at 605 W. 18th St. in the IGA Center next to Beall's and just up the street from the church's main sanctuary and facility at 801 W. 18th St.
Already, the facility has become a gathering place for church members and their friends, as well as other community residents, college students and coffee and tea lovers of all ages.
"It's gone beyond our expectations," said Victory Life Church Pastor David Markham. "It isn't limited to any one church or denomination, by any means. We'd encourage and love to have a lot of people use it as a place of fellowship. It's a fun, relaxing atmosphere. And there are very few places where people can go late in the evening around here, so it's nice to have this open now."
Markham, who has been involved with Victory Life Church since September of 2001, said his wife Francie came up with the idea of starting a coffee house in Portales more than a year ago, similar to one she had seen near their previous home in Tulsa, Okla.
"Everyone who comes in to The Coffee House seems to really like it," Francie Markham said. "They like the peacefulness here."
The Markhams both said that while The Coffee House maintains a Christian theme and atmosphere, it's open to everyone.
"It's a clean environment that's smoke-free and alcohol-free," David Markham said. "The entertainment we have will be Christian-oriented."
Portales native Laci Lee, who attends First Baptist Church, said she has already been to The Coffee House several times since it opened because she enjoys the atmosphere.
Victory Life Church members contributed funding to start The Coffee House as a community outreach and place for fellowship and ministry.
"It's just been a walk of faith," David Markham said. "I started looking at this building over a year ago. We were outgrowing our facility, and it just looked like a natural for us to expand along the block. We worked out a lease with the owner and came in and just transformed the place — and now, it's a beautiful facility."
Proceeds from the non-profit business go into maintaining The Coffee House and supporting the church's youth outreach, he said.