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Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway
- Brandon W Higgs1,
- Zheng Liu1,
- Barbara White1,
- Wei Zhu1,
- Wendy I White1,
- Chris Morehouse1,
- Philip Brohawn1,
- Peter A Kiener1,
- Laura Richman1,
- David Fiorentino2,
- Steven A Greenberg3,
- Bahija Jallal1,
- Yihong Yao1
- 1Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, USA
- 2Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA
- 3Department of Neurology, Brigham Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
- Correspondence to Dr Brandon W Higgs, Translational Sciences, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA; higgsb{at}medimmune.com or Dr Yihong Yao, Translational Sciences, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA; yaoy{at}medimmune.com
- Accepted 13 June 2011
- Published Online First 28 July 2011
Objective To characterise activation of the type I interferon (IFN) pathway in patients with systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid arthritis (RA) and systemic scleroderma (SSc) and to evaluate the potential to develop a molecular diagnostic tool from the peripheral blood that reflects this activation in disease-affected tissues.
Methods Overexpressed transcripts were identified in the whole blood (WB) of 262 patients with SLE, 44 with DM, 33 with PM, 28 with SSc and 89 with RA and compared with 24 healthy subjects using Affymetrix microarrays. A five gene type I IFN signature was assessed in these subjects to identify subpopulations showing both activation and concordance of the type I IFN pathway in the peripheral blood and disease-affected tissues of each disease and to correlate activation of this pathway in the WB with clinical measurements.
Results A common set of 36 type I IFN inducible transcripts were identified among the most overexpressed in the WB of all subjects. Significant activation of the type I IFN pathway in subgroups of each of the five diseases studied was observed. Baseline disease activity measurements correlated with a type I IFN gene signature in the WB of subjects with SLE, PM and SSc, as did various serum autoantibody levels in subjects with SLE and DM. This signature was also well correlated between disease-affected tissue and WB in subjects with SLE, DM, PM and SSc.
Conclusions The results indicate that the type I IFN pathway is activated in patient subsets of five rheumatic diseases and suggest that these subsets may benefit from anti-IFN therapy.
BWH and ZL contributed equally to this work.
Funding The study was supported by MedImmune LLC.
Competing interests MedImmune is developing anti-type I interferon therapy for autoimmune diseases. BWH, ZL, WZ, WW, CM, PB, LR, BJ and YY are full-time employees of MedImmune and SAG has served as a consultant for MedImmune. The Brigham and Women's Hospital manages research sponsored by MedImmune and intellectual property pertaining to myositis diagnostics. DF is not a paid consultant of MedImmune and is an employee of Stanford University.
Ethics approval This study was conducted with the approval of the institutional review boards from the different sites or commercial vendors and all subjects provided informed consent.
Provenance and peer review Not commissioned; externally peer reviewed.


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Dear Members,
Keep in mind that Character Bashing is now prohibited. Making fun of certain characters/character pairings leads to a pointless thread filled with insults and general rule breaking.
Also, remember that Versus threads are allowed only in the Versus section.
Thank you, NarutoBase Staff
If he dies will you be sad ?
I will be very sad , Kakashi is one of my true favorites. He's a real cool guy but at the end of the day, he's just a drawing. I'd get over it
Ofcourse...he is one of my fav character... :/
Yes yes I well but plot demands it
I feel he is gonna die .
Yes, maybe more sad than when Asuma died.
i hav a feeling that he's gonna die ...i want to c team 7's reaction when they find out kakashi's death
Hella sad
No.... I kinda got over the thought of Kakashi's death the first time he died
i will be sad but it will be the first death beside or rather than pnj
No I will throw a party.
Not until he shows us whats under his mask :D
lol but yes i would be
Depending how he dies.
Sadder than any deaths. When the Pain Arc my school underwent something called "Disciplinary action" an all senior year students must sleep at school dorm with no internet. So i dont know kakashi is dead back then.
yeah id be disappointed . i wouldnt say manga has ever made me sad
kakashi is comin out that ***** with 2 mangekyos and a cadaver
First reaction:
After realizing:
It goes on:
Most definitely:
Not done:
And finally:
Originally Posted by Red Hot Fury
if he dies this is me
Originally Posted by Renadollface
First reaction:
After realizing:
It goes on:
Most definitely:
Not done:
And finally:
Omw. Perfect reaction!
This will totally be me
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About RussianFox : If you don't agree with my views on a topic I couldn't care any less because I know most people wouldn't insult me if they were standing in front of me in real life. If I say your wrong about something and prove it don't make a pathetic attempt at saving your dignity because it's already gone. MlP:FiM Forever.
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Today, it's my boyfriend's birthday. He really likes Legend of Zelda, so I put on a Link hat, took my clothes off, and waited for him at his place. He came home with a hooker. FML
by excusemeprincess / 02/11/2013 at 12:08pm / United States (New York) / Love
Today, my girlfriend got a tattoo of a Rainbow Dash over her pubic mound. Now whenever I go down on her, I'll be eye-to-eye with an adorable pony that shits rainbows. FML
by nobrony / 07/02/2012 at 3:53pm / United States (New York) / Intimacy
Today, my girlfriend got a tattoo of a Rainbow Dash over her pubic mound. Now whenever I go down on her, I'll be eye-to-eye with an adorable pony that shits rainbows. FML
by nobrony / 07/02/2012 at 3:53pm / United States (New York) / Intimacy
Today, I foolishly told my husband that I know he's been holding back sexually, and that I was willing to indulge any sexual fantasies he may have. Now it seems that tonight, I'll be responding to the name "Fluttershy". FML
by Anonymous / 06/25/2012 at 6:08pm / Denmark (Hovedstaden) / Intimacy
Today, I was at work, reading some funny stories on my phone. Just as one of my co-workers decided to share that his father had passed away recently, I burst into uncontrollable, teary-eyed laughter at a story. They don't believe my explanation, and have branded me the office asshole. FML
by Anonymous / 06/05/2012 at 2:47pm / Brazil (Sao Paulo) / Work
Today, I was trolling in a chat room when someone said, quote: "He's just a no-life, unemployed loser still living in his mom's basement. Probably spends all day stroking his tiny dong and fantasizing about having a real girlfriend." I actually started crying because it was so accurate. FML
by pathetic / 04/23/2012 at 6:06pm / Poland (Mazowieckie) / Geek
Today, while watching TV with my wife, I realized that we were still watching "My Little Pony" even though the kids had been asleep for half an hour. FML
by ajnmegs / 04/19/2012 at 12:08pm / United States (Colorado) / Miscellaneous
Today, while my boyfriend and I were getting intimate, he called me "Mom." FML
by ohgod... / 04/01/2012 at 10:18pm / Canada (Quebec) / Intimacy
Today, while I was on the bus to work, a morbidly obese man sat down next to me. When my stop came and I stood up to get off, he just looked at me, said with a smirk, "good luck with that," and went back to reading his paper. I missed my stop. FML
by busfail / 03/22/2012 at 2:00pm / Canada (British Columbia) / Transportation
Today, I told my daughter that she should put some love into her cooking. She started kissing the ingredients. FML
by FoodyFood / 03/19/2012 at 12:59am / Australia (South Australia) / Kids
Today, at work at a gas station kiosk, a man requested a carton of cigarettes. We keep our cigarettes on a high shelf. I'm short and very large chested so I have to jump in order to reach the carton. He said, "I only come here for the entertainment" and left without purchasing his cigarettes. FML
by aprilmay91 / 03/11/2012 at 8:38am / United States / Work
Today, I was re-watching my wedding video. As I was walking down the aisle, you could hear my grandfather mutter "Here comes the bride, all fat and wide." FML
by Anonymous / 03/10/2012 at 9:20am / United States (New Mexico) / Love
Today, it was my first day working as a nightclub bartender. All through the evening, a really creepy bloke stood in a dark corner and leered at the girls on the dance floor. When I took the bouncer to one side to let him know, he told me the man was a coat stand. FML
by Bob smith / 12/19/2011 at 3:57pm / Australia (New South Wales) / Work
Today, I went to the pool with my new white bathers. I felt really good about myself because everyone was staring at me until this hot guy came up to me and said "Dude, your bathers are see-through. You need to shave!" FML
by Embarrassed Swimmer / 12/11/2011 at 2:23am / Australia (Victoria) / Miscellaneous
Today, I saw my neighbor's Christmas tree they had put up on their porch, with decorative presents under it. Being that my neighbors hate me, I figured I would take a present to piss them off. While walking back home with the present, I opened it. Inside it read "I knew you would, douche bag." FML
by lebato97 / 12/08/2011 at 10:35pm / United States (Louisiana) / Miscellaneous
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Posts Tagged 'announcement'
Need for Speed Getting a Reboot
Deep Customisation, Authentic Urban Car Culture, Open World, and Immersive Narrative All Feature in the Reboot of the Famed Need for Speed Franchise Guildford, UK – May 21, 2015 – Ghost Games™, an Electronic Arts Inc. (NASDAQ: ...
Firekom Announces the First Soccer MMO – Global Soccer
Firekom announced today their new game called Global Soccer. It allows players to try and become the soccer star that they always wanted to become. What makes it different is this has RPG like tendencies in that you aren'...
Wastelands Interactive Strategic War in Europe
Wastelands Interactive announced today a new strategy game titled "Strategic War in Europe". It is being developed for the PC exclusively and will feature in-depth elements of an old school strategy game with modern...
Planetside 2 – Lightning Tank Screens
Sony released Planetside back in 2003. Recently they have announced that Planetside 2 is coming and with a beta to boot. No official release date or even quarter has been set. What we do know is the basic story and we have seen...
Crysis 3 Announcement Trailer
EA has officially released the Crysis 3 Announcement trailer. The game is launching sometime in 2013. Stay tuned to Gamersciz for the latest information on Crysis 3.
League of Legends Teases Next Champion – Hecarim (UPDATE)
Riot games has released a single screenshot, or rather a piece of concept art, teasing us with what the next Champion will look like. They are calling him Hecarim or "Shadow of War", and within the screenshot one ca...


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National Chung Cheng University - CCU
National Chung Cheng University - CCU
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The CCU campus is a beautiful park with serenity and openness.
National Chung Cheng University (CCU)
was the first public University established after Taiwan's economic boom in the 1980's. In order to commemorate the late president Chiang Kai-Shek and to develop higher education in the Yun-lin, Chia-yi and Tainan areas, the Executive Yuan passed a plan in 1986 to establish
. It was officially founded on July 1, 1989 with Dr. Lin Ching-Jiang as the first president of the University. Dr. Lin, as the founding president of the University, set up the original five colleges of the University, namely, the College of Humanities, the College of Sciences, the College of Social Sciences, the College of Engineering, and the College of Management. During the tenure of the second president of the University, the College of Law was founded in 1998, and the College of Education in 1999. Altogether, the University currently consists of seven Colleges, with 449 faculty and staff members, 5844 undergraduate students and 2662 graduate students. During 2001-2007,
turned to put more emphasis on electronic technology and globalization.
then became the first university in Taiwan to open e-learning master programs to the public and is also credited with the best English friendly learning campus around the nation. Dr. Luo was also devoted to building a closer relationship with the industries, promoting
as one of the leading universities in technology licensing and business incubation.
was founded to be a research-oriented University which aims to provide students with necessary skills in humanities, the sciences, technology, law and management. It is this type of liberal arts education that allows students to effectively deal with the complexities in the 21st century. The campus is located in the central part of Chia-yi county, 15 kilometers from the city of Chia-yi, which is approximately 250 kilometers south of Taipei. The campus occupies an open landscape of 132 hectares on a hill, with more than 200,000 trees of various species. On a campus tour, one cannot help but be struck by the elegant buildings of different architectural styles, surrounded by tall trees, open green spaces, and winding roads flanked with flowering trees and bushes which bloom in different seasons. The campus itself is a beautiful park with serenity and openness and is literally a breath of fresh air in comparison to Taiwan's more urban campuses. Viewed from the plains below, the University looks like a splendid palace on a hill, but the ivory tower image is only physical, as the university serves the community in many ways. The Gymnasium is one of the most splendid and expensive constructions in southern Taiwan. It has two Olympic-sized swimming pools (one indoors and one outdoors), a roller-skating rink, bowling alleys, and indoor courts for basketball, volleyball, and badminton. In addition, it has rooms for Judo, weight-lifting and circuit training, indoor rock climbing walls, an outdoor Olympic track and field stadium, and of course, ping-pong facilities. Last, but not least, the sprawling campus even has a golf course with 20 fairways.
Description and information about accommodation
Taiwan, Taiwan
Taiwan, Taiwan
A comfortable living environment is tremendously important for an overseas student. Having a safe and relaxing place to stay helps foreign students adapt to the new culture and to excel in their studies. The campus is guarded by its own police force, and everyone is conscious of safety. Accidents can occur, but there is an excellent, full-service hospital within ten minutes drive to handle any kind of injury.
There are five 10-floor buildings that serve as the dormitories for undergraduate students, offering 2,548 beds. Four people share a room with a bathroom and a phone. A lobby, toilet, filtered water dispenser, and a storeroom are installed on each floor. A Laundromat, a music room, a room for practicing the piano, a computer room, and an entertainment room are provided on the lower floors. The reading room on the top floor provides a private space for reading and making friends with people from different countries. There are five European style buildings as the dormitories for graduate students providing 1,102 beds. There are 90 beds in single and double room configurations available for doctoral students at
. Students can concentrate on their studies in such a peaceful and graceful environment. Students may also live off campus to experience the local life and obtain an in-depth understanding of Taiwanese culture and customs. The Division of Student Life can provide rental information and assistance.
Contact information for National Chung Cheng University - CCU
National Chung Cheng University - CCU
168 University Road
Min-Hsiung Chia-Yi
Taiwan ROC
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When the world ends, people can either turn on each other or turn to one another for help. That's the idea behind this E3 cinematic for The Division. Ubisoft has certainly shown us enough gameplay up until now, but a cinematic trailer released not long ago reminds us that the end of the world can be an emotional thing.
As the video opens on New York City during the height of the outbreak, a voice-over grimly narrates mankind's descent into desperation and fear. Those who don't die early have to face a new post-apocalyptic reality, which isn't something everyone is willing to do.
Anyway, I recommend giving the trailer a look. Yes, the overall message is a positive one, and it ends on a relatively high note.


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|By Benjamin (Benjamin) on Tuesday, August 03, 2004 - 04:14 pm: Edit
After buying all of my electronic stuff, I noticed a small stipulation on microwaves...it has to be 600 watts or less. Have any of you ever seen a microwave less than 600 watts? Do they exist? And I've only seen one or two that were actually 600 watts. As compact as my little microwave is, it is 800 watts. What if I just brought it anyway? Would that be a serious problem? Would I be on the bad list before school even starts? WHAT SHOULD I DO? Please help me...
|By Massdad (Massdad) on Tuesday, August 03, 2004 - 04:49 pm: Edit
Schools don't want a brown out (or worse) when everyone starts warming up water for coffee first thing in the morning, hence the power limit.
What would I do? I would send an email to the school and ask them! I suspect you will get dispensation. If not, you can buy a 600 watt machine for under $50.
BTW, have you coordinated such things with your roommate to be?
|By Emeraldkity4 (Emeraldkity4) on Tuesday, August 03, 2004 - 05:19 pm: Edit
my daughters school doesn't even let them have microwaves in their room. What would you be using it for?
Often dorms have full kitchens to make stuff, you can get a small hot pot/kettle to make tea or heat up soup if you don't want to go to the kitchen, but I imagine dorms have lots of fire risks anyway, and to add the risk of heating up a nice casserole in a gold edged pan or what one former student at Reed did in the kitchens microwave which was try and make crack @@, I can see why colleges want to restrict what is in the rooms.
(I have fire on the brain- a federal team that worked on Oklahoma city is in town investigating arsons that have been set just blocks from me- 12 over the weekend)
|By Benjamin (Benjamin) on Tuesday, August 03, 2004 - 06:44 pm: Edit
Actually, I won't have a roommate, I'm in a single....but thanks for your comments even though they were somewhat rude.
|By Emeraldkity4 (Emeraldkity4) on Tuesday, August 03, 2004 - 06:51 pm: Edit
which comment was rude? I don't see asking questions for more information as rude, after all you came looking for help right?
I could have been much more specific I suppose and instead of asking what are you going to use your microwave for, said Microwave are used for many different things, I can see that if you wanted to heat up frozen dinners you would need a microowave, but if what you wanted was to heat liquids there are many other alternatives that take up less space. If you wanted to cook in your room there are alternatives to that tooo, but as Massdad pointed out, there are ways to bring a microwave and fulfil the dorm requirements.
|By Ariesathena (Ariesathena) on Tuesday, August 03, 2004 - 10:10 pm: Edit
Sears has a handful of microwaves which are 700 watts.
AND, here is a microwave at Walmart for 600 watts of power:
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Cooking Up a Storm This Thanksgiving? Don't Dump That Grease
Put your waste oils and fats in a container, not the drain.
Put your waste oils and fats in a container, not the drain.
Turkey and all the trimmings expected to cost 3 percent less than in 2015.
Dozen organizations hold events providing meals to those who can't afford them.
Tucson- and Hermosillo-based brewers work together to create Beer Without Borders.
Over 100,000 visitors expected for 43rd edition of the event featuring food, music and more.
Pima County team fights stigma against reclaimed water; finalist for innovation distinction.
Food banks: 18.4% of Tucson families with children struggle to feed them.
NAU professor's research aimed at helping communities head off future crises related to water scarcity.
Designation aims to draw millennial foodies to authentic, local eateries.
Presidio Museum will offer booming cannon, mariachi music, free food.
Part 5: As downtown rediscovers its place, some businesses move in, others depart.
Iridescent insect is active during summer months in Southern Arizona.
Cheaper prices in the dairy section lead the decrease, with eggs, some meat nlower, too.
Many sites open this week, additional cafeterias start service Monday.
Dímelo producer Sophia Paliza-Carre finds out what it takes to make a desert taste like Tucson
13th Annual Pie Party will benefit several nonprofits, provide treats.
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About PADI
About PADI – Professional Association of Diving Instructors
Learn more about PADI: FACT: PADI is the world's largest recreational
diving membership organisation. PADI Dive Certifications are recognised
by more dive operators worldwide than any other certifying agency.
PADI [Professional Association of Diving Instructors] is the world's largest recreational diving membership organisation. The PADI membership includes dive businesses, resort facilities, academic institutions, instructor trainers, dive educators, divers, snorkellers and other water sports enthusiasts.
Professional PADI Members (dive centres, resorts, educational facilities, instructors, assistant instructors and divemasters) teach the vast majority of the world's recreational divers, issuing more than 800,000 certifications each year. PADI Professionals make underwater exploration and adventure accessible to the public while maintaining the highest industry standards for dive training, safety and customer service.
SCUBAFISH Dive Centre is a PADI 5 Star, Gold Palm, IDC,
Dive Resort based in Ko Lanta Thailand
Scubafish holds the following PADI Dive Centre ratings:
PADI Resort
A PADI Dive Center or Resort is a professional business that specializes in the retail sale of recreational scuba equipment, dive instruction and dive services. To qualify as a PADI Dive Center, the business must commit to meeting and maintaining professional business standards aimed at raising dive customer satisfaction. Plan your next dive vacation with one of more than 3000 PADI Resorts worldwide. PADI Resorts specifically cater to scuba divers and snorkelers. With activities like scuba and snorkel instruction, introductory scuba experience programs, guided dive tours and snorkeling excursions and dive equipment rentals, PADI Resorts are the perfect choice for traveling divers.
PADI Five Star Dive Centers
The PADI Five Star Dive Center membership level is awarded to progressive PADI Dive Centers that excel in providing divers with a full range of diver education programs, equipment selection, and experience opportunities. To qualify as PADI Five Star Dive Centers, an operation must meet elevated service and business standards, and promote and offer PADI courses as their only recreational diver training. These dive centers also actively promote aquatic environmental awareness and embrace the PADI System of diver education, with a commitment to providing customers with quality products, services and experiences.
PADI Gold Palm Resorts
Quality accommodations, superior service and excellent dive opportunities make PADI Gold Palm Resorts stand out from the rest.
Resorts of this caliber focus on customer satisfaction, memorable dive experiences, diver safety and environmental awareness by going the extra mile to provide professional and outstanding service. Offering new divers safe and easy beginner scuba programs to more advanced and adventurous dives including wreck diving, cavern diving, deep diving and shark dives.
PADI Five Star Instructor Development Center
A PADI Five Star Instructor Development Center (Five Star IDC) not only meets all PADI Five Star Dive Center standards, but also meets additional training standards required to offer PADI Instructor-level training.
A PADI Five Star Instructor Development Center (IDC) offers diving guests a wide range of programs to fulfill their educational goals from entry-level training up through instructor-level certifications.
You can complete your training as a PADI OWSI or MSDT Instructor ratings at a PADI Five Star Instructor Development Center.
PADI Gold Palm Instructor Development Center
A PADI Gold Palm Instructor Development Center (Gold Palm IDC) not only meets all PADI Gold Palm standards, but also meets additional training standards required to offer PADI Instructor-level training.
A PADI Gold Palm IDC offers diving guests and students a wide range of scuba diving programs geared towards fulfilling your educational goals from entry-level, beginner diver training up through to instructor-level certifications. All of this can be completed within a relaxed and comfortable resort setting.
Scubafish – PADI 5 Star, Gold Palm IDC Centre in Ko Lanta, Thailand
awarded Project AWARE Go ECO status
Scubafish has been awarded the Project AWARE Go ECO status in recognition of the environmentally friendly dive practises we follow.
The main objective of Go ECO is for dive centres to minimise their impact on the aquatic ecosystem whilst contributing to environmental, economic and cultural conservation. Dive centres are required to meet best practice environmental guidelines and commit to the Project AWARE Go ECO philosophy.
"SCUBAFISH is delighted to be awarded with the Project AWARE Go ECO Operator status for 2007. As a Go ECO Operator we are committed to providing dive experiences that enhance visitor awareness, appreciation and understanding of the local aquatic environment," said Saffron Kiddy – Dive Centre Manager.
Joanne Marston, Manager, of Project AWARE Asia Pacific added, "We are pleased to recognise SCUBAFISH as a Go ECO Operator. We look forward to working with them to implement environmental best practices and educate tourists about how they can travel responsibly."
Go ECO Operators also demonstrate a commitment to conservation and pledge to follow the Go ECO Operator guidelines.
The PADI system of diver education is based on progressive training that introduces skills, safety related information and local environmental knowledge to students in stages. PADI courses are student-centred and provide for maximum practise and application.
Students learn the basics through independent study and then are guided through additional development by their instructors. The goal is to get students in the water as soon as possible and provide them with instruction necessary to gain confidence in their diving abilities.
All PADI programs, fall under strict educational standards to maintain worldwide consistency and quality.
With thousands of members and millions of divers, PADI-sponsored programs are becoming a growing force in the worldwide effort to preserve the underwater environment. Project AWARE (Aquatic World Awareness, Responsibility and Education) encompasses PADI's environmental awareness and protection philosophy. Through their training, PADI divers learn the importance of protecting fragile aquatic ecosystems and are encouraged to become involved in preservation efforts.
Further Information about PADI
For further information about PADI, please visit their website at http://www.padi.com
To find out more about Project Aware, and how you can help to protect our ocean's reefs, please visit http://www.projectaware.org
Make a difference: Support Project Aware! Support projects include:


text:
Wood County resident convicted of drug charge
PARKERSBURG – A Wood County man charged with a drug offense in 2012 was convicted Wednesday in Wood County Circuit Court.
Justin Randolph Stukey, 31, in custody at the North Central Regional Jail and was indicted by the May 2013 grand jury, was found guilty of a charge of delivery of a controlled substance after a one-day trial. His sentencing was set for 10:30 a.m. Nov. 25 before Judge Robert Waters.
Stukey also is set for trial on Nov. 19 on additional charges from a separate indictment in May 2013 charging him with two counts each of breaking and entering, entering without breaking and grand larceny and one count each of petit larceny and destruction of property.
In a sentencing in circuit court, Daniel Armando Banales, 34, in custody at the North Central Regional Jail, was sentenced to one year in jail after his July conviction on a charge of petit larceny. He was acquitted by the jury on a breaking and entering charge from the indictment.
Waters denied a defense motion for probation and sentenced Banales to one year in jail with credit for 156 days served. Banales was ordered to pay $77 in restitution to Camden Clark Medical Center.


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A surprising article about "integrative" medicine in The New England Journal of Medicine vs. "patient-centered" care
The New England Journal of Medicine (NEJM) is published on Thursdays. I mention this because this is one of the rare times where my owning Mondays on this blog tends to be a rather large advantage. Fridays are rotated between two or three different bloggers, and, as awesome as they are as writers, bloggers, and friends, they don't possess the rabbit-like speed (and attention span) that I do that would allow me to see an article published in the NEJM on Thursday and get a post written about it by early Friday morning. This is, of course, a skill I have honed in my not-so-super-secret other blogging identity ; so if I owned the Friday slot I could pull it off. However, the Monday slot is good enough because I'll almost always have first crack at juicy studies and articles published in the NEJM before my fellow SBM partners in crime, unless Steve Novella managed to crank something out for his own personal blog on Friday, curse him.
My desire to be the firstest with the mostest when it comes to blogging about new articles notwithstanding, as I perused the table of contents of the NEJM this week, I was shocked to see an article that made me wonder whether the editors at NEJM might just be starting to "get it"—just a little bit—regarding "integrative" medicine. As our very own Mark Crislip put it a little more than a week ago:
If you integrate fantasy with reality, you do not instantiate reality. If you mix cow pie with apple pie, it does not make the cow pie taste better; it makes the apple pie worse.
Lately, though, I've been more fond of a version that doesn't use fancy words like "instantiate":
If you integrate fantasy with reality, you don't make the fantasy more real. You temporarily make your reality seem more fantasy-based, but reality always wins out in the end.
The part about the cow pie needs no change, although I think ice cream works a bit better than apple pie. Your mileage may vary. Feel free to make up your own metaphor inspired by Mark's.
In any case, in the Perspective section, I saw three articles about "patient-centered" care:


text:
Apple-Cranberry Salad
1/4 cup KRAFT Real Mayo Mayonnaise
1/2 cup Sour Cream
1Tbsp. sugar
3 apples (preferably 2 red and 1 green), chopped
1/2 cup chopped PLANTERS Walnuts
1/4 cup dried cranberries
1 stalk celery, thinly sliced
6 leaf lettuce leaves
Make It
MIX mayo, sour cream and sugar in medium bowl. Stir in all remaining ingredients except lettuce.
REFRIGERATE 2 hours.
SERVE over lettuce.
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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Wanted: Suspect for Robbery in the 25th District [VIDEO]
The Philadelphia Police Department is seeking the public's help in identifying the suspect for a strong arm robbery on the "R" route SPETA bus in Hunting Park.
On June 22, 2013, at 11:44am, the complainant, a 19 year-old male, was on the "R" route SPETA bus approaching the Broad Street and Hunting Park Avenue bus stop. When the bus stopped and as the suspect was exiting the bus he snatched the complainant's iPhone from his hand and fled the bus.
- Suspect Description: Black male, medium complexion, wearing a light colored shirt with white writing on the front, gray jean shorts with black and white sneakers.
- To view the surveillance video: Visit The Philadelphia Police YouTube Channel or visit http://phillypolice.com/news
- If you see this suspect do not approach him, contact 911 immediately.
- To submit a tip via telephone, dial 215.686.TIPS (8477) or text a tip to PPD TIP or 773847.
- Use this electronic form to submit a tip anonymously.
If you have any information about this crime or this suspect, please contact:
East Detectives Division
Det. Waddell #9159
1 Comment
Wanted: Suspect for Robbery in the 25th District [VIDEO] | Philadelphia News
[…] Jun 25, 2013 […]


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text:
Gavvy Cravath
Career w/Phillies: .291 AVG / 117 HR / 676 RBI / 80 SB
Part of the 1915 National League championship team, Clifford Carlton Cravath was not just a skilled hitter, but very likely the second best hitter of his time. Between Honus Wagner in the early 1900s and Rogers Hornsby and Babe Ruth in the 1920s, there was Ty Cobb, and there was Gavvy. For seven consecutive seasons he hit more than 20 doubles, averaging 10 triples per season in that period. And he was also a potent home run hitter, maxing at 24 (a single-season "modern-day" record until Babe Ruth broke it in 1919) in that special 1915 season. He led the league in homers that season, and in five other seasons. He led the league in RBI two times, and led the league in OPS three times. He finished second in MVP voting in 1913, when he hit .341 with 19 homers and 128 RBI, a career-best season. These days that would likely be a 60-homer, 160-RBI season. He was that good. Sadly, he never got a great chance in the majors — after starting slow, the White Sox traded him to the Washington Senators, who quickly moved him to a minor-league team. He didn't get regular playing time until he landed with the Phillies at age 31. The rest, however, is history.
Comment: Gavvy had a seven-year run almost unparalleled in Phillie history. He was easily the National League's biggest home run threat, and just a downright great offensive player. Compared to those ahead of him, Cravath lacked longevity and superior all-around play. But ultimately, Cravath was — for a couple years — the biggest home run hitter in baseball. Not necessarily a Hall of Famer, he comes eekingly close
15 Comments
Damn, this may have ruined my top 10
If the 1918 Phils had decent pitching they would have likely won the NL Pennant. Their offense included Cy Williams, Irish Meusel, and Hall of Famer Dave Bancroft, along with Gavvy himself. and Fred Laderas at fist base. This was a solid lineup.
hey, unrelated, but saw this on the zo zone –
The Phillies reassigned the following players to minor-league camp: righthander Yorman Bazardo; infielders Ozzie Chavez, Anthony Hewitt and Terry Tiffee; and outfielders Jeremy Slayden and Chris Walker.
I'm surprised to see Slayden on this list.
I know, I know…this is Tim's list, etc. But this is a forum for debate, so I respectfully disagree.
Cravath dominated the era he played in. he might not have as gaudy numbers as players who will probably come higher in this list (luzinski has to be coming soon) but he was arguably the best player in the game for a few years…players like luzinski werent the best on his team.
I feel he couldve been higher
I'm with Dan L. But we'll see the rest of the list.
Dan L makes the most compelling argument on this site yet for a certain players' misplacement on this list…
I assumed Cravath was easy top 10
This list is like a work of art. The players are being judged with a good blend of objective statistical parameters as well as subjective intangibles (team value, fan support…) that has included fairly all eras of Phillies baseball. Unless your limiting your argument to a focused comparison of 2 or 3 similar players such as the Burrell/Luzinski/Ennis comparison, condemning (not questioning) the position on the list is a bit of an exercise in futility. The inclusion of active players was a risk that appears to be working out OK judging from their spirited comment logs.
Can't agree with this one.
What I mean't but "not questioning" is that questioning OK in contrast to condemning.
I can't believe you forgot the story of how he got his nickname. Gavvy started with the LA Angels of the Pacific Coast League in 1903. Sometime before his contract was sold to the Red Sox in 1907, he hit a ball that killed a seagull in flight. The Spanish for seagull is "gaviota" and Cravath was known as Gavvy ever since.
One of my favorites.
I think that Gavvy could have been a few notches higher… one of the best outfielders in franchise history. He hardly received any HOF votes, less than 2%, when he retired. That is mainly because he didn't have a very long career. It says that the only reason he got a chance in the major leagues at the age of 31 is because the word "not" was inadvertantly left out of a telegram… that's how legends are born. His OPS+ numbers are unworldly.
Never heard of this guy before this post, but wanted to give him some props. He's 5th all-time in Phillies history in Adjusted OPS+, per baseball-reference.com, which is probably his most impressive stat. On stats alone, he probably should have won the 1913 MVP, losing to some dude on Brooklyn (who only beat out Cravath in batting average .350 to .341).
This guy was definitely one of the best players in the league, in his era, based on stats. Very surpsrised to see that he only got MVP votes in 2 years (1913 and 1914), only to see that apparently no MVP award was given from 1915 to 1921. He would have been a top contender for the NL MVP in '15 after leading the league in HRs, RBI, OBP, SLG, Runs, Total Bases. His biggest competition may have been Pete Alexander. MVPs were odd back then, pitchers were seriously considered, batting average seems to have been valued over power (Babe Ruth only won it once), and being on a pennant winner counted a lot. Then there's Johnny Evers who won the NL award in 1914 after not finishing in the Top 5 in any offensive statistical category, but his Braves won the pennant and beat the A's in the World Series. (Sherry Magee had a far, far better year, and finished 7th in the voting.)
But yeah, only 7 years with the Phils (and years 1913-1915 stand out as his peak). I do wonder how he'll compare on this list to Abreu and Luzinski (both played about 8.5 years with the Phils) and Dick Allen (8 years, but only 4 years with more than 122 games). Allen is #2 in Adjusted OPS+ in Phillies history and had about 300 more plate appearances than Cravath.
After learning about him, I could definitely see him ranked a little higher, but not quite Top 10.
Thinking more and more abut Gavvy's professional journey…if he had played today, how many of us would think he took PED's?
Today, a player not having significant major-league success until age 31, and then all of a sudden being the premier power threat in all of baseball, would definitely spark a fair amount of suspicion.
Just something to think about….
By the way… that is an awesome picture, Tim. The other guy is Tris Speaker (both managers, at the time).
I never heard of this guy before this post…but he strikes me as the Phillies version of Roy Hobbs. Tim may overstate his 'seven-year run' — three years stand out, 1913-1915, per baseball-reference.com. Looking at modern-day stats, he would easily win the MVP in '13. His case is weaker in '14 (though Johnny Evers won without finishing in the Top 5 in any offensive category, screwing over Sherry Magee), but he or Pete Alexander are easily the MVP in 1915 (after he led the league in HRs, RBI, OBP, SLG, Runs, Total Bases, his only relative weakness a .285 batting average) — but no award was given from '15 to '21. Anyway, his three peak years are amazing.
Curious to see how he ranks versus Luzinski and Abreu (about 8.5 years as a Phillie) and Dick Allen (8 seasons, but only 4 with more than 122 games).


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September 18, 2014
Two Months Later, OSU Discloses After-Hours Clinic Data
In its first full year of operations, Ohio State's after-hours clinic at Martha Morehouse ran a $75,000 surplus on total operating revenue of more than $713,000, according to a public record provided to The Dispatch this week.
The after-hours clinic opened in October 2012, in part to help reduce volumes in the University Hospital emergency department. The clinic had more than 7,000 patient visits during the fiscal year that ended June 30, so that means revenue per patient visit was roughly $100.
I requested this data from the public university two months ago, on July 17, for an article about the growth of urgent-care centers. The university's initial, informal response was that university officials weren't "very interested" in providing the data "unless they're assured that all our competitors are providing that information."
That rationale is not a very good compass for a public university to follow when it comes to public records.
So I filed a formal public-records request on July 21, which - after several follow-up emails - eventually led to the release of the information this week.
The university also recently declined two of my other public-records requests, citing a "trade secret" exemption to shield from public view:
- the methodology used for determining the compensation of its top-paid doctors;
- planning documents developed by the university's medical center for future use of the space vacated when the new cancer and critical care hospital open.
I'm glad the university ultimately did not withhold the after-hour clinic finances from public view. But it still has a long way to go in operating transparently - and in fulfilling requests for public records in a timely fashion.Posted by Ben Sutherly on September 18, 2014 04:00 PM


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The Arenacross tour will be back in the UK in January 2016 for eleven nights of motocross action.


text:
Go sports crazy at the next Discover After Dark event at the Don Harrington Discovery Center, 1200 Streit Drive.
Guests at "Sportsology," set for 7 p.m. Friday, can practice their golf swings, take part in a sumo wrestling tournament or hang out with friends over games of ping pong or foosball.
The event also inclues an open bar, hors d'euvres by Rory Schepisi and music.
The Discovery Center's After Dark events is an evening series for adults.
Admission is $30 for DHDC members and $37 for nonmembers. For information, call 806-355-9547 or visit www.dhdc.org.


text: Please tell us what sorts of tools you have to work with. That is, what topics are surrounding this problem? How are you expected to work it? I ask because I know the correct answer but I had to use the programming ability of a computer algebra system to solve it. I have not found any way to model this problem using counting techniques.


text:
Hey spacemenon.
What I think they mean by this question is that you need to have a value that is less than 0.001. If you choose for example 0.0009 then the answer you get for n is 81.84179 which gives an answer for n = 82 (which is in agreement with the textbook answer).
Remember that it has to be less than 0.001 which means you can't actually use 0.001 but a value that is lower and for this I choose one decimal unit down from 0.001 which is 0.0009.
I use the same technique you used just with a different critical value.


text:
It's your first day in Paris and you're already set to dazzle the fashion world with your fabulous style skills! Time to live out your dreams in the new social game, Fashion Icon, now available for free on iPhone, iPad, & Android. Hit the streets of the fashion capital of the world and create your own style with designer clothes from the dozens of chic boutiques. Create your dream outfits, start your own fashion blog, and show your rivals you're a diva to be reckoned with, in Fashion Icon!
Me, Myself and I
Personalization is a major feature of Fashion Icon, so be prepared to change your look, starting with the color of your eyes, to the shape of your lips. And have fun with it! As you level up, get a chic new hairdo and discover the wonders of a new 'do! You might even earn style points for it!
New Girl at the Party
Fashion Icon brings the party to a whole new level, as you'll earn experience by going to events and showing off your outfit in style battles. Every girl's got to know that fashion isn't just about clothes, it's also how you strike a pose. So prepare you best smile, and grab some tricks up your sleeve. The world of fashion is a competitive place, and rivals soon show up to challenge you. Luckily, you're not afraid of these wannabes, and every success brings you and your blog new fame!
What To Wear… What to wear?!
One of the things I loved the most about the game was the fact that the outfits were very versatile, with more than 1000 pieces of clothing available! You'll never get bored searching the racks at your favorite boutiques again! ;) Even cooler, whatever the season or trend, you'll find an outfit to match! Search the racks and find some of this summer's hottest fashion items: maxi dresses, peplums, mandarin orange heels… You name it; it's all there!
Chat'em Up
Without admirers, there would be no "icons," so get ready to turn some heads and start flirting. See if you can snag a real catch, because your BF's cheer will boost your confidence. Your +1 might even give you a present or two if you're lucky! Isn't that something?
But remember not to hog the conversation. Pay attention to what your man likes and try to bring up his interests. Who knows, maybe it'll be true love… If not, at least you're going to have a great time!
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Aaah…Paris.. The best place on Earth for friends to have fun with fashion! Invite some of your best (& most fashionable) friends to join you in your quest to be the ultimate fashionista in a town filled with real fashion aficionados. You can follow your friend's fashion faux pas and Parisian adventures on their style blogs and send each other special gifts… You're going to have a blast! And if you're in need of more fashion-y friends, you can post your Gameloft LIVE! ID on our official Fashion Icon forums here. Cause everyone can use more friends!
And for those divas already playing, here's a little tip for you: layer, layer, layer! Use a combination of jackets and tops to maximize your style points. Plus, don't miss our super fashionable Fashion Icon Giveaway! Upload a photo of your most fashionable outfit for a chance to win a 64GB iPod Touch! Enter now & keep an eye on our Fashion Icon Facebook page, for more tips, news, & contests!
Have fun, girls!


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Records from the Mary Floyd Tallmadge Chapter of the Connecticut D.A.R., 1905-1909
Daughters of the American Revolution,
est. 1890 Oct. 11
Washington, D.C.
Collection size: 90 items (on partial microfilm reel).
Collection Summary: Records relating to the Chapter's commission of a memorial window for the Litchfield Historical Society. Included are: letters, 1905-1907 between Frederic Crowninshield, the artist who executed the commission, and members of the Window Committee (including Elizabeth C. Barney Buel, Chairman of the Committee and Regent of Chapter), two letters, 1905, from Russell Sturgis, architect, to Buel, one letter from Buel to Rev. Stoors O. Seymour, President of the Litchfield Historical Society and his reply to her,
and one letter, 1905, from Charles R. McNeil of Ross & McNeil, the architects who built the Litchfield Historical Society. Also includes fourteen committee reports submitted by Elizabeth C. Barney Buel and the Book and Unveiling Committees; an undated brochure explaining the memorial window project and soliciting contributions; and a program from the official unveiling of the window, July 5, 1907.
Biographical/Historical Note: Founded 1899.
These records window, were given to the Litchfield Historical Society in 1909, when the project was completed.
How to Use this Collection
- Microfilm reel 3679 available at Archives of American Art offices and through interlibrary loan.
- The Archives of American art does not own the original papers. Use is limited to the microfilm copy.
- For more information on using the Archives' resources, see the FAQ or Ask Us.


text:
New Videos
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April 2nd, 2013 by John Kim / 16
With a confirmed release date of October 26th, it"ll be a tough wait to bear until the Air Jordan IV "Fire Red Nubuck" Retro release to hit stores. By then, it would have been over a year since we first saw Carmelo Anthony's PE version – the one he broke out after taking home a Gold Medal at the London Olympics. There's no question that these will be a must-have for the Holiday 2013 season, along with the upcoming Air Jordan Doernbecher release in November/December and the XI, but is the Fire Red Nubuck the best of the bunch? Check out the high-def images below and see what the asking price is on this size 9 sample from makingbeatz on eBay.
Air Jordan IV
Fire Red/White-Black-Cement Grey
Filed under: Air Jordan eBay Upcoming Sneakers
Pages: 1 2
Hit us up if you still need a pair [gotnewkix at gmail]
@gotnewkix don't buy from this scammer
Sneakernews how are these samples, no pic clarifies these as samples. The pics u guys showed earlier in the year were samples or early productions. Those had a grey and red on the patch of the tongue and a white and grey bottom on the outsole. These have the white, grey & red patch on the tongue and a grey bottom thru out the outsole. These are the fire red 4's they plan on releasing exactly like this. How do yall show pics and not notice the difference.
Pics of these mean nothing. Need to see the suede in person I have a feeling theyre gassing the red and its actually going to be alot lighter.
CopN 4sho
What's up with those taxi 12s tho?
HOLY SHIT SN enough with these already I don't care who has them early for sale -_-
Subscribe to the Sneaker News Youtube Channel


text:
The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
Love you too!
Your email has been sent!
You'll catch yourself singing a happy tune each time you wrap this pale-pink scarf from Disaster Designs around your neck! No matter where you're flying off to today, the intricate illustration of blue hummingbirds, bountiful black blooms, and lavender polka dots offers a fun and feminine touch to your black dress, shimmery tights, and peep-toe flats!
Final Sale: This item cannot be returned or exchanged.
Sorry this item isn't available anymore


text:
Drafts and galleys of Writer: A Life of Jack Kerouac and The Exile of Celine; Kerouac chronology; notes for the 1986 Olson Lectures; holograph notebooks; typescript poems and articles by Clark (b.1941).
[Box/folder# or item name], Tom Clark papers, Collection no. 0151, Special Collections, USC Libraries, University of Southern California
COLLECTION STORED OFF-SITE. Advance notice required for access.
All requests for permission to publish or quote from manuscripts must be submitted in writing to the Manuscripts Librarian. Permission for publication is given on behalf of Special Collections as the owner of the physical items and is not intended to include or imply permission of the copyright holder, which must also be obtained.
Tom Clark is a poet, editor and biographer who resides in California. He has published biographes of Jack Kerouac, Ted Berrigan, Robert Creeley, Charles Oleon, Edward Dorn, and Celine. He served as editor of The Paris Review from 1963 to 1973 and has published numerous volumes of poetry with Black Sparrow Press. Charles Olson was one of his poetic mentors.


text:
One thing I thought that might help to for initial combat encounter character placement is a marching order.
Here is my take on a marching order, but let me know if you want to change anything.
Single Wide 5'
Double Wide 10'?
I will be posting this to the Campaign Tab as well.
Magic Items for Sale in Sandpoint.
75% Chance for any item up to 1,300gp.
Recheck 1 week.
Unique Items
There is a chance they will be sold during the month to a NPC.
New items will be checked for once per month.
12. Savah's Armory
Unique Items:
Spiked Chain
12 MW Shuriken
+1 Reapeating Light Crossbow named "Vansaya" 2,550GP
+1 Bronze Breastplate [Small] 1,350GP
+1 Heavy Steel Shield 1,170GP
+1 Chain Mail 1,300GP
+2 Mighty Cleaving Kukri [Large] 18,316GP
14. Rovanky Tannery
Unique Items:
+3 Studded Leather of Fire Resistance 27,175GP
17. Bottled Solutions
Unique Items:
Potion of Levitation CL3 300 GP
44. The Feathered Serpent
Unique Items:
Scare Scroll CL3 Cost 150GP
Moment of Greatness Scroll CL2 Cost 50GP
Summon Minor Ally Scroll CL1 Cost 25GP
Divine Mending Wand 4 Charges CL 1 30GP
Magic Aura Wand 8 Charges CL 1 120GP
Wondrous Items:
Robe of Useful Items 7,000 GP
Boots of Speed 12,000GP
Stone of Good Luck 20,000 GP
|Scoria the Stalwart
Hmm. Scoria does need to replace the Shuriken she's already used. 12 MW Shuriken should be 73gp 2sp, (50 ammunition gaining full MW price, Shurken sold at 5 units for 1gp, 50 shuriken being 10gp, MW +300gp, 310gp for 50, 10 being 61gp, 2 more adding 12gp 2sp.)
Anyways, does anyone mind Scoria buying the Shuriken? Since it's a communal gold pile now.
|Thaddeus Pruitt
Do shuriken act like ammunition? They break after a hit or are recovered 50% of the time? I guess they do, Yuk, that sucks. I think they would be more like daggers.
I have no problem if you want to buy MW ammo, it just always seemed like a waste with the limited use aspect. Granted, it may have to wait until we return from our trek after the gobbo graverobbers.
|Midori Masaki
Just a heads-up: My family and I (me, hubby, daughter [who's now 19!)] are going on a vacation trip this week. We're leaving Tuesday and will be back late Sunday.
We're taking a lap-top so I should be able to post at least once a day except Tuesday.
Tuesday - drive to Orlando
Wednesday- if need be finish drive, then alternate Universal/Islands Of Adventure
Thursday - alternate Universal/Islands Of Adventure, night time for the haunted stuff
Friday - drive to Busch Gardens Williamsburg, park stuff & haunted stuff
Saturday - drive to King's Dominion, park stuff and haunted stuff
Sunday - drive home, collapse
I'm not abandoning anything, but I may not be real coherent
To save time, DM-Valkur, you have permission to NPC me during any fights.
|Khrondak Iron Forged
Hey guys, just wanted to inform that on top of a killer week on my job, my fianceé's grandfather passed away this morning and we'll be attending the funeral. Long story short, I won't be able to post for at least until tonight, hope to find some time later so as to not let you guys down. See you later.
|Midori Masaki
|Khrondak Iron Forged
They were close, yes; he had been living with her parents for the last couple of years and we saw him often. But, he was 94, so it wasn't completely unexpected. We're glad he was lucid and well and didn't spend his last years sick in a bed, it started last week and progressed kind of fast, so for the most part I think he didn't suffer much or burden anyone.
Thanks for your words and understanding. Anyways, I'm back now. :)
|Scoria the Stalwart
On the subject of loot, I'm of the opinion of Need before Greed. For example, Scoria would probably get a lower share of the loot, due to not needing as much expensive equipment, while our other fighters may need MW equipment soon enough. Midori in particular needs a ranged weapon, I think, and the only thing that Scoria might need are some MW shuriken, since she's a flurry thrower.
So, in summary, we should just agree to buy as we need, like potions and scrolls for our spellcasters and MW weapons for our fighters.
|Khrondak Iron Forged
As long as no one gets frustrated and everybody has access to cool magic items, I'm fine with a communal pool. In-character, Khrondak will behave as if he's entitled to a share.
And I'm fine with buying Midori a crossbow. :)
|Thaddeus Pruitt
Okay, so I will be going through the motions of "paying" each member their "share" when it comes to loot? In the end it will all be IC, but OOC we are just pooling, buy what is needed for each member.
Scoria, I do have a question about the MW Shuriken. It costs 29.5 gp more gold for 5 shuriken to be MW. The price is 30 times more than a regular one, but it is only a one shot item. As ammunition, if it hits, it is destroyed. If it misses, there's only a 50% chance it can be re-used. I'm not saying no, or even that it's my decision, I'm just asking if you are sure it's worth the extra cost, and you really want to spend it?
It's a +1 to hit, on 12 throws (or as flurries 6 rounds of combat) for 73gp.
|Khrondak Iron Forged
I've never been a fan of spending on ammunition, I just don't think it's worth it... usually I save for bigger rewards later.
Ok, I've just realized the upside of having split shares - spend however you want without having to negotiate with the other players.
|Midori Masaki
|Notick Mostriaré
But but but... What about the townsfolk!
Just keeding!! I'm, personally, more prone to prefer even split in finances. It eliminates the need to rationalize other people's purchases, and it also prevents jealousy of items.
E.G. - A +10 Falcata of Awesome is offered for 2000 gold, and a +10 Earthbreaker of Horror is offered for 2000 gold. It's the only time in the game it would be offered. Who gets what they want?
However, I wouldn't mind OOCly hybridizing our money so it's even split, but someone could ask for help to purchase something, in which we then can offer to pay up to help (Like everyone is willing to do for Midori!)
|Scoria the Stalwart
I'm planning on optimizing Scoria's build to be about hitting hard with shuriken flurries - a lot of Sacred Mountain abilities stem on her staying in the same square. MW Shuriken may seem expensive, considering that they're consumed, yes - but at these lower levels, having that +1 to hit makes a big difference when it comes to combat. Though she'd probably save them for when she really needed the extra accuracy.
|Scoria the Stalwart
I can't get to any shared document sites like google docs or google drive or whatever it's called these days from the office, but if we want to go with the shares method I can put together a spread sheet when I get home tonight.
While I'm not a huge fan of lots of bookkeeping in my games (my players track money, but not weight or encumberance for instance) it seems like it might be helpful in this case.
Let me know if that's something you all would like me to put together. If it'll help, I'll be happy to do it.
|Thaddeus Pruitt
Okay, so what I'm hearing is a preference for even splits.
Here's what I'm thinking -
Coin: Split 7 ways, (1 share each, 1 party pool)
Items: Go to whoever needs it most, if no one will use it, it gets sold
Sold Items: The money from all sold items goes to the coin split. That means even if say Midori finds a +1 shortbow, uses it from finding to selling, it is not her money from selling, it is shared money.
To do otherwise means having to track the value of each and every item, each member receives, to account for equal value. It is just easier to split all sold items amongst the whole, even if they were used exclusively by only one person.
EDIT: Bel'Tanis, we shouldn't need a doc, if we are only tracking coin shares. Which is another reason it is easier with all coin (even from sold items) going to split. That way we either have items we are using, items we are selling, and each coin share. Once you get into each person's WBL value based on what they have/use, then you run the headache of excess bookkeeping. Sometimes, it's just a whole lot easier to put it all in one big pile, and buy what we as a party need for the party.
In that case, with the 726 gp we earned from the spoils of the raid, that'd be a party split of 103.7gp for each of the 6 party members and 103.8gp to the group share?
EDIT: Just saw Thaddeus' in-game post. I'm fine with splitting evenly to the gold piece and any extra silvers/coppers going into the party fund if that works for everyone.
|Thaddeus Pruitt
I just figured rounding to the nearest gold, with all spillage going to party pool, would be a cleaner split. Do we really want to break it down to the last copper?
EDIT: Just saw Bel'Tanis' edit. Disregard, unless this is also an issue.
|Khrondak Iron Forged
|Midori Masaki
|Scoria the Stalwart
|Midori Masaki
|Thaddeus Pruitt
|Notick Mostriaré
Big storm rolling in on Virginia and the Carolina's. There was another storm that went through the mid-west, which when it meets the hurricane, is suppose to cause even more turmoil.
Heart's with'ya Bel'Tanis. Stay safe!
|Thaddeus Pruitt
|Midori Masaki
Pittsburgh here. They're saying it could get this far.
Oh, and just a tiny bit of humor: there's a movie called Superstorm. When I saw all the indicators for Frankenstorm, they looked a lot like the setup for this.
|Khrondak Iron Forged
|Midori Masaki
|Scoria the Stalwart
No sweat, Valkur. In a similar vein, I'll be travelling for the weekend and won't be back until Tuesday night. I should have reliable internet access throughout, so I doubt it'll be a problem but I could be wrong.
I still kinda feel like I need to talk about the unfortunate sequence of events at the general store with the group and with Ameiko before we head off into the next thing though. Hopefully Ameiko might have some insight as a long-time member of the community into how to best deal with the store owner and his amorous daughter. =\
I've decided to give everybody in the party the same amount of XP, even though certain party members where not present at various encounters. Makes it a lot easier on the bookkeeping.
The Desecrated Vault:
4 Skeletons x 135xp
90XP per party member
The Shopkeeper's Daughter:
Story Award: 400xp
67XP per party member
The Boar Hunt:
1 Advanced Boar x 800xp
134XP per party member
The Trouble at The Rusty Dragon:
Story Award 400xp
67XP per party member
Monster in the Closet:
1 Advanced Goblin Ranger 1 x 400xp
67 per party member
Total XP per party member:425XP
Cumulative XP Total:1030
Getting Close to 2nd!
Monster in the Closet
Unidentified Potion
Small Masterwork Studded Leather Armor (95 GP Sale Value 10% Included)
Small Masterwork Dagger (165 GP Sale Value 10% Included)
Small Shortbow (17 GP Sale Value 10% Included)
20 Arrows (1 GP Sale Value 10% Included)
GP Total:278(Assuming you sell everything)
I've updated the campaign tab for the unique items available in Sandpoint.
Equipment shops in town:
1. Sandpoint Cathedral (Divine Potions and Scrolls)
4. The Way North (Maps)
5. Jeweler (Gems)
8. Sage:Brodert Quink
12. Savah's Armory (Metal Weapons and Armor)
14. Rovanky Tannery (Leather Armor)
16. Pillbugs's Pantry (Supplies)
17. Bottled Solutions (Potions)
19. House of Blue Stones (Monk Items)
23. Sandpoint Theater (Music Instruments)
26. General Store (Bel'Tanis knows this place well :))
27. Turandarok Academy (School, and possible arcane items)
44. The Feathered Serpent (Misc. Items)
75% chance of an item under 1300gp. + the special items listed in the campaign tab.


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Well I figured I'd post my sigfig since he'll most likely be apearing in almost ALL of my brikwars (yes thats right) so without ferther stalling....
"Hey Mike, when is BrikWars 2010 done? I really need to know!!" - Dürer, 2016
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Chiefs coach Reid talks up Raiders in a big wayIf the Raiders make it to the Super Bowl this season, it won't come as a surprise to Kansas City Chiefs coach Andy Reid. Overall, Reid has a take on that, as well. First, here's what Reid had to say about the Raiders special teams: "If you look at special… (more)Source: insidebayarea.com
Raiders try to play takeaway with SmithUnedited version sent for print . . . Being Alex Smith means dealing with backhanded compliments. The quarterback of the Kansas City Chiefs got another one the other day, courtesy of Raiders quarterback Terrelle Pryor. Pryor, when asked if he aspired to…Source: insidebayarea.com
Double Coverage: Raiders at ChiefsThe Kansas City Chiefs last beat the Oakland Raiders at Arrowhead Stadium on Nov. 19, 2006. The 17-13 victory was secured only in the final moments, when safety Jarrad Page intercepted a pass from quarterback Aaron Brooks in the end zone. Since then, th…Source: ESPN.com


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November 1999
Michael Mason is a first-class flute player who presents differing collaborations in various settings on this disc.
The most dynamic are those pieces with a full band orchestration, including the compelling trombone of Steve Berry, the piano of Kirk Brown, and multiple bass and percussion players. In these pieces, the group achieves dense textures, with the swirling, cascading piano and vigorous modern rhythm setting an exciting tableau for rich, modal explorations by the combination of woodwind and brass, in potent improvisations.
These pieces are set off by shorter works for flute and percussion that are atmospheric, if less inspiring, but complementary to the over-all scheme of this well-conceived album.


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November 13, 2012
A new concept for a constantly adaptable prosthetic limb might use 3-D printing
Most amputees go through a lot of prosthetics in a lifetime. This can be expensive, especially in the developing world. The Beth Project aims to change that by making a prosthetic that can change along with the human body. FastCompany reports.
The product is aimed particularly at the developing world, where up to 30 million people require prosthetics, according to the World Health Organization.
The issue is not so much about cost--cheap prosthetics exist, and many used ones are donated--but the need for specialists to adjust or replace the sockets. WHO says 180,000 trained staff are needed, and that theres a current shortage of about 40,000. Outfitting an average prosthetists clinic, complete with grinders and vacuum formers, costs $70,000, according to Hill, and thats before you hire personnel to run it.
"Initially, we were thinking about making a cheaper socket, maybe using 3-D printing, or some other advanced manufacturing technique," Hill says. "But then we found out the real problem was the shortage of trained care. The 40,000 figure really jumped out at us.
Read full article. Watch video.
The Permanent Link to this page is: https://textually.org/3DPrinting/2012/11/031306.htm


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B.C. Ruins & Hezbollah Gunfire!
Trip Start Dec 23, 2007
267Trip End Ongoing
Of course I could go on with the history lesson, but the more interesting aspect of my visit was that while I was strolling the grounds, machine gun fire resonated close by...followed by artillery shelling! It seems that about 1 kilometer away Hezbollah (Party of God) was fighting insurgents of some sort. As the gunfire intensified, I settled myself inside the ruins with their almost 2 feet thick walls and waited for the noise to die down with 2 Frenchmen who were stuck in Lebanon due to volcanic ash. So we discussed the nice things in life - war, natural disasters, the Reckoning - and went our ways once the war zone relaxed a bit! Fun, fun, fun in Lebanon! :)


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March 2014 Recipe of the Month
This month's recipe of Coconut Lime Bars is featured in Sweet & Savory Cooking, Miraval's newest cookbook created by Executive Chef Justin Cline Macy and Pastry Chef Kim Macy. These citrusy bars are the perfect way to welcome the warmer weather!
"Everybody loves this kind of slightly fancy bar cookie, especially my version with fresh lime juice and lime zest—although, the classic lemon version is pretty great, too. These are easy to make—just press the crust into the pan—but they're delectable enough to serve as a dessert for guests or to bring to a cookie swap. I use coconut oil instead of butter in the crust, which has a wonderful flavor and no cholesterol. You can add toasted coconut to the top for garnish if desired." - Pastry Chef Kim Macy
- 1½ c. graham cracker crumbs
- 2 Tbsp. coconut oil
- 2 Tbsp. melted butter
- 2 Tbsp. granulated sugar
- Pinch salt
- 3 Tbsp. granulated sugar
- 2 Tbsp. cornstarch
- 1 can (14-oz.) low-fat sweetened condensed milk
- 1 egg
- 1/3 c. fresh lime juice
- ¼ c. low-fat coconut milk
- 1 tsp. finely grated lime zest
Make the crust: Heat the oven to 350°F. Grease an 8-inch x 8-inch baking pan with nonstick cooking spray. In a small bowl, combine the graham cracker crumbs, oil, butter, sugar, and salt. Press the crust into the bottom of the prepared pan. Bake for 10 minutes or until lightly brown, remove from oven, and let cool at room temperature.
Make the filling: In a medium bowl, whisk together the sugar and cornstarch. Whisk in the condensed milk, egg, lime juice, coconut milk, and zest, whisking until smooth. Pour the filling over the prepared crust.
Bake for 25 minutes until lightly set in the center, taking care not to overcook. Let cool at room temperature for 30 minutes and then transfer to the refrigerator to cool for 1 hour or until well chilled. Cut into 16 squares.
Serving Size: 1 two-inch bar calories: 174 total fat: 5 g carbs: 27 g dietary fiber: .5 g protein: 3 g
Purchase Miraval's Sweet & Savory Cookbook>
5 responses to "Recipe of the Month: Coconut Lime Bars"
tracy shaw Says:
Mar 12, 2014 at 11:51 PM I am allergic to dairy ( cow ) and gluten. Do you think I could substitute coconut cream for the condensed milk?
Thanks much!
Mary Larson Says:
Mar 18, 2014 at 5:20 AM try replacing the graham cracker crust with equal amount of whole wheat saltine crackers. Salt/sweet taste replaces the overbearing sweetness of the graham cracker. Also, from picture, looks like toasted coconut. Do you add in last 3 - 4 min of baking time to toast, or add toasted coconut after it is finished?
Deb Says:
Mar 20, 2014 at 10:52 PM Is it ok to replace the cornstarch with Arrowroot powder? Any special instructions on that or other substitution?
I am also interested in your answer on substitutions for the condensed milk as I do not eat that either.
Anna Says:
Mar 21, 2014 at 2:12 PM I'm disappointed that, given it's focus on wellness, Miraval doesn't think ahead and provide vegan and gluten free options. I echo the questions already posted by others. In addition, I experienced the same thing while visiting Miraval - very limited or no vegan options. I'd often have to request a special meal from the server. Please reconsider your approach to the posted recipes. Thanks.
Miraval Says:
Mar 27, 2014 at 2:40 PM Hi all,
We always encourage experimenting in the kitchen with substitutions that meet your dietary needs. We understand that you put your health in our hands during your stay with us and our chefs are always willing to accommodate dietary restrictions, food allergies, etc. We promise that no matter what your dietary needs may be, you will be blown away by our award-winning cuisine.
Please discuss your dietary needs with a Miraval Advisor by phone prior to your arrival and we will note your reservation and alert the culinary team accordingly.


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Texlynx Hired by Company Character World UK textiles
May 18, 2009-- Home Textiles Today,
Texlynx has been hired by juvenile bedding and bath developer Company Character World as its sourcing agent in Pakistan.
Company Character World is the UK licensee for Disney, Nickelodeon, 20th Century Fox, Lucasfilm, Chapman Entertainment and other entertainment and sports properties.
Texlynx will be responsible for sourcing, product development, quality control, tracking, shipping and communication within the country.
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cheats and hack tool – Download Link: http://tinyurl.com/newpoucheats ::See video for our website link:: New Hack Special Features: -Get Unlimited Game Potions – Pou Coins and Skill Poins Pou Hacks Free Coins – No rooting – Best Version Pou Hack Pou Hack has now really been no.1 option of the gamers. It is the first tool to come in mind for every players because it can easily generate the needed Potions, coins without too much effort and messing with codes. – Pou Cheats 999999 Coins and Potions No rooting — Working Pou Hack – 2013 CHEATS CODE for games
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Cleveland Clinic's Section of Cardiovascular Imaging uses the most advanced technology available to capture images of the heart. These various techniques allow physicians to make accurate diagnoses and determine the best treatment for each patient. They also offer better patient safety during treatments. These specialists are referred to as "imaging physicians" because they determine the most appropriate way to image or study the structure and function of the heart in order to diagnose many types of heart disease. They are also experts in the treatment and long-term management of many types of heart conditions.
Obtaining and interpreting images of the heart are critical to the successful management of any cardiac disorder. Our cardiovascular imaging specialists pioneered the use of stress echocardiography to evaluate heart valve disease, hypertrophic cardiomyopathy, aortic aneurysm, patent foramen ovale, and diastolic dysfunction in patients with amyloidosis and constrictive pericarditis. We also use transesophageal echocardiography (TEE), nuclear imaging, cardiac MRI and coronary CTA.
hic_What_is_CardiomyopathyCardiovascular imaging physicians are also experts in the treatment and long-term management of many types of heart conditions including:
Cleveland Clinic's Section of Cardiac Imaging is one of the largest and most experienced in the country. Our staff reads and interprets nearly 50,000 images every year.
Cardiovascular imaging specialists have pioneered the use of stress echocardiography in evaluating heart valve disease, hypertrophic cardiomyopathy, aortic aneurysm, patent foramen ovale, and diastolic dysfunction in amyloidosis and constrictive pericarditis.
Imaging specialists in the Section of Cardiovascular Imaging utilize the following diagnostic studies to diagnose heart disease, plan optimal care for patients, and help ensure treatment is complete. They also use these diagnostic studies to minimize complications during many types of catheter-based procedures and heart surgery.
Heart & Vascular Outcomes
Our outcomes speak for themselves. Please review our facts and figures and if you have any questions don't hesitate to ask.
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"I told the girls if they could maintain the intensity and energy that we displayed during the first set, then we will be a team to contend with in district," said Lady Trojan head coach Larry Lollar.
Beeville varsity girls sport a 5-10 record going into district play on Friday.
The Lady Trojans captured set one easily. Strong serves were a key along with a hustling defense and net play. The Cherokees had no answer for the Beeville service game as return after return was deflected wide or into the net. The Lady Trojans cruised to a 25-11 victory in set one.
Theresa Amador, Natalie Elder, J.J. Hernandez and Krista Gonzales all pounded the ball on serves in that first set.
The Cherokees regrouped and played the Lady Trojans to a close three-point win in set two at 25-22 for the visitors. That second set was tied at 15-15 but the Cherokees managed to go up 20-16 to help earn the win.
Set three was all T-M as the energy and momentum left the building for the Lady Trojans. It was a 25-15 win for the Cherokees to edge in front in the best of five match two sets to one.
The visitors dominated set four for a 25-8 win and captured the match 3-1.
Brennan Holder led the Lady Trojans with eight kills in the match. Hernandez followed with four. Gonzales finished the night with 12 assists. Holder had three blocks at the net, while Randi Maupin followed with two blocks.
Elder came up with 13 digs to assist the Beeville defense. Gonzales added six digs for JHS in the match.
Hernandez and Elder each served one ace in the loss.
The Lady Trojans were in Rockport last night (Friday) to open District 30-4A play. The Beeville girls will play Moody next Friday after a bye on Tuesday night. The battle of the Lady Trojans will be in Beeville with the freshman match getting under way at 5:30 p.m.


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Prices, specials, features and availability subject to change.
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Pet Policy: 2 pet maximum, 70 lbs weight limit. For pets up to 25 lbs there is $500 pet deposit with $250 refundable. For pets over 25 lbs there is $700 non-refundable pet fee. Breed restrictions apply.
Cats Allowed. Dogs Allowed. Call for service animal policy.
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Multiple repairs need during the short time there. Also, after moving out, communications can not be establis Read Morehed to clear up an electric bill that Ashford Apartments should be responsible for. They turned the electricity back on but the account was still in my name.
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The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
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It's impossible to pinpoint which part of this grey sweater you love most! You tell your BFF that the classic, layered look from the front is your fave, but when your neighbor compliments your ensemble, you give a spin to showcase the all-plaid back. How about a compromise? We say both sides combine to create the perfect pullover!
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Servo Magazine (February 2008)
MAKER Fair
By R. Steven Rainwater View Digital Edition
What do robots have in common with recycled clothes, root beer, and medieval siege weapons? Why are the creators of these wonderfully interesting things suddenly more visible than they were in the past? What is Hyperbolic Origami? These are a few of the questions I pondered as I drove from Dallas to Austin, TX for the 2007 Austin Maker Faire. I had just returned from a road trip to Marfa, TX for the annual Chinati Open House art festival. It struck me as I took in the art and talked to the ...