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Project Director
Diana Laurillard
George Magoulas
Project Details
Funded by TLRP/ESRC/EPSRC
Sept 2008 to August 2011
Project Website
under development
Learning design,
learning patterns,
professional development
Our main focus is to discover how to use digital technologies to support teachers in designing effective technology-enhanced learning (TEL).
We assume that:
Laurillard, D. (2008). Open teaching: The key to sustainable and effective open education. In T. Iiyoshi & M. S. Vijay Kumar (Eds.), Opening Up Education: The Collective Advancement of Education through Open Technology, Open Content, and Open Knowledge. Boston: MIT Press.
Laurillard, D. (2009). The pedagogical challenges to collaborative technologies. International Journal of Computer-Supported Collaborative Learning, 4(1), 5-20.
Laurillard, D., & Masterman, E. (2009). TPD as online collaborative learning for innovation in teaching. In O. Lindberg & A. D. Olofsson (Eds.), Online Learning Communities and Teaching Professional Development: Methods for Improved Educational Delivery. Berlin: Springer.
The London Knowledge Lab was a unique collaboration between two of the UK's most prominent centres of research - the UCL Institute of Education and Birkbeck. The Lab brought together computer and social scientists from a very broad range of fields.
more >>
UCL Knowledge Lab
23-29 Emerald Street
London WC1N 3QS
United Kingdom
Birkbeck Knowledge Lab
Malet Street
London WC1E 7HX
United Kingdom


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Baffert seeks second Arkansas Derby score with War Academy
Den's Legacy is more comparable to Baffert's dual classic winner Real Quiet, who also entered his final Kentucky Derby prep in 1998 a veteran of 11 starts. Den's Legacy is less accomplished than Real Quiet was at this point in the season, but has proven to be a consistent check earner. Following a victory in the Generous on turf in his juvenile finale, Den's Legacy has started the year off with seconds in the Sham and Robert B. Lewis, and a third in his first attempt over the Oaklawn strip in the March 16 Rebel.
The resurgent D. Wayne Lukas barn will be represented in the Arkansas Derby by Oxbow, who missed by a head to stablemate Will Take Charge in the Rebel after leading through most of the stretch. The Awesome Again colt was a dominating 11 1/2-length hero of the Lecomte at Fair Grounds in January, and then was a close fourth in the Risen Star over the same track before the Rebel.
Overanalyze, who gave owner Mike Repole and trainer Todd Pletcher victories last season in the Remsen at Aqueduct and the Futurity at Belmont Park, will attempt to rebound off a disappointing effort in the March 2 Gotham at the Big A. Favored at 8-5 but drawn outside in post 11 in that 1 1/16-mile affair on the inner dirt, Overanalyze was hung wide around both turns and failed to muster a rally in a fifth-place effort.
Frac Daddy finished up the track in both the Holy Bull and Florida Derby earlier this year, failing to show progress off a solid second-place finish in last November's Kentucky Jockey Club at Churchill Downs. Texas Bling, meanwhile, failed to seriously threaten in either the Southwest and Rebel following a near-miss second in the January 21 Smarty Jones.
The Arkansas Derby field is completed by stakes victor Heaven's Runaway, a distant third in the Southwest last time; multiple stakes-placed Divine Ambition, who was cross-entered in Saturday's Blue Grass at Keeneland; and allowance winner Carve.
Ten three-year-olds with less lofty ambitions will contest the $100,000 Northern Spur, a one mile event, earlier in the card.
Bet Horseracing Free Online at TwinSpires.com
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"The Matchmaker" is the opening-night presentation of the 25th Israel Film Festival, which will take place Oct. 20-Nov. 4 and has grown to be the largest showcase of Israeli films in the United States. But don't expect a heartwarming shtetl romance or a Hollywood-ish "Father of the Bride" comedy.
The movie has its humorous moments, but basically it is an honest though sympathetic view of the underbelly of Israeli society: its outsiders, from scarred Holocaust survivors and black-market dealers to prostitutes and — I kid you not — seven dwarfs. It will be the first of more than 30 features, documentaries and television programs that will spotlight how far Israeli cinema has come in the last quarter-century; the fare will include Yigal Nidam's "Brothers," about two siblings who personify Israel's religious and political conflicts, nominated by the European Film Academy for best picture in 2009; the doomed Arab-Israeli romance "Jaffa," an official selection at both the 2009 Cannes and Toronto International Film Festivals; and an homage to producer David Silber of "Lebanon," the Golden Lion winner at Venice which has just been nominated for the European Academy and International Federation of Film Critics' Prix Fipresci for best first feature.
"The Matchmaker" is set in Haifa's Lower City, the often gritty harbor area, far from the well-appointed homes on Mount Carmel with their magnificent views of the Mediterranean. The time is 1968, one year after Israel's stunning victory in the Six-Day War.
Yankele Bride (Adir Miller), the matchmaker, is right at home in this milieu. A Holocaust survivor whose back story we never learn, he is a man with a scarred face whose professional motto is, "I'll give you what you need, not what you want," and who "specializes in special cases" among his clientele.
One such case is Sylvia (Bat-El Papura), caught up in the real-life story of seven Romanian dwarfs, fancied by Dr. Mengele for his Auschwitz experiments, who came to Israel and opened a movie theater in the Lower City, showing only romance pictures, mainly from India.
With her beautiful, luminous face, Sylvia "has a big heart in a small body," as Yankele tells potential suitors.
Then there's Meir (Dror Keren), the shy librarian who takes lessons in the social graces from the beautiful and mysterious Clara (Maya Dagan), who hides her Holocaust scars and is Yankele's constant companion and ally in some of his shadier dealings.
Joining this odd set of characters is Arik Burstein (Tuval Shafir), a 17-year-old sabra from a middle-class family, who is recruited by Yankele to scout for new prospects and as a private eye to check out backgrounds of dubious clients.
Arik yearns to become a soldier and war hero but in the meantime is a voracious reader of the then-popular Stalag novels, in which sadistic Nazis made sport with voluptuous Jewish women prisoners.
The boy shares the belief of most Israelis of the time that the Holocaust survivors in their midst were kind of freakish and must have done something highly immoral and devious in the camps to escape death.
Since Arik's own parents are survivors, he dares not ask them about their own experiences, even if they are willing to discuss them, for fear of what he might find out.
While Israel's outsiders continued to struggle, for most young natives 1968 was the year they discovered the summer of love, rock music and other American innovations.
For Arik, love comes in the shapely form of Tamara (Neta Porat), daughter of a wealthy Iraqi family, who was raised in the United States. She brings startling news of women's liberation and free love, and jumps fully clothed into a water fountain during a chaste scout meeting.
Avi Nesher is director and co-writer of "The Matchmaker," and the film reflects much of his own life and upbringing.
He grew up the son of Holocaust survivors who never spoke of their past, and, as a 15-year-old in 1968, Nesher absorbed the changes brought about by the Six-Day War victory and the youthful revolts of the decade.
Nesher spent much of his adolescence in the United States, returning to Israel for his army service — where, to his embarrassment, he found out that he now spoke Hebrew with an American accent (and English with an Israeli accent).
At 23, he made his first film, "The Troupe," an instant hit about an army entertainment group. He followed with a number of other successful movies but received so much flak with his 1984 picture "Rage and Glory," about the pre-state underground Stern gang, that he decided to leave for Hollywood.
During a decade in the movie capital, he made a series of low-budget films, which made the studios — and him — a nice pot of money.
However, as his children grew up, he decided it was time to return to Israel, and right away scored big with the 2004 movie "Turn Left at the End of the World," which became the highest-grossing movie in Israeli history.
"The Matchmaker" is Nesher's most personal film to date, and while he abhors the idea of making a genre Holocaust movie, it is a subject that he — and Israel — cannot leave behind.
"The memory and mythology of the Shoah is in our DNA, for good or for bad," Nesher said in a lengthy phone interview. "This catastrophe is still unresolved; it needs to be discussed and understood. It is part of the dialogue between myself and my kids."
"The Matchmaker," he insisted, is not a Holocaust film. "It is mainly a coming-of-age movie, about a kid growing up. He learns about the Holocaust, while at the same time finding out about the nature of love."
Nesher feels equally at home in Israel and in the United States, he said, and writes in English and Hebrew with equal fluency. He acknowledges, though, that he would find it difficult to survive in the Jewish homeland without being able to follow his beloved New York Giants on ESPN.
His family reflects the international outlook. "My father came from Romania, my mother is from Russia, my wife is Italian, and my kids are American," he said. His next film will be about an American woman living in Israel.
Nesher will come to Los Angeles for the screening of "The Matchmaker," which won two Ophirs — Israel's equivalent of the Oscars — one for Adir Miller in the title role as best actor, the second to Maya Dagan (Clara) as best actress.
However, best picture honors, and thus automatically Israel's official entry in the Academy of Motion Picture Arts and Sciences' foreign-language film category, went to Eran Riklis' "The Human Resources Manager."
Nesher, now 57, finds making movies in Israel "intoxicating," with special psychological rewards. "When I run on the beach in the morning, some seven or eight people will stop me to say something nice about my last picture or ask me what I'll be doing next," he said.
The Israel Film Festival offerings will be shown at Laemmle's Sunset 5 in West Hollywood, Royal in West Los Angeles and Fallbrook 7 in West Hills, according to Meir Fenigstein, IsraFest's founder and executive director.
On Oct. 20, a gala awards dinner at the Beverly Hilton will honor actor Richard Dreyfuss and producers Ryan Kavanaugh, Jon Landau and Avi Lerner.
For ticket information, go to israelfilmfestival.com or call (877) 966-5566.
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Men's Kyboe! Chronograph Silicone Strap Watch, 48Mm
Embossed indexes and a trio of sub-eyes detail the partially textured dial of a chronograph watch engineered with Citizen Miyota movement for precise, reliable timekeeping. A screwed-down tachymeter bezel and a smooth silicone strap add edgy, modern touches to the design. Color(s): white/ rose gold. Brand: KYBOE. Style Name:Kyboe! Chronograph ... Learn More


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British troops could be withdrawn from Germany for good, nearly 70 years after the end of the Second World War, if the Conservatives win the general election, it emerged last night.
Liam Fox, the Shadow Defence Secretary, said that it was "no longer necessary" to keep more than 20,000 military personnel in the country. Ending the commitment would free up forces to carry out vital Nato operations outside Europe, he said.
Generations of soldiers and their families have passed through Germany, although the size of the force deployed to the country has been scaled down over the years. The presence


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Evil Queen Halloween Makeup Tutorial
Here is the last Disney Villain look (for this year!): Evil Queen! I see the Evil Queen as being someone who puts beauty over everything else. She would want the latest skincare and makeup and would be up with the latest trends, and would above need to be the fairest one of all :)
I wanted this look to be traditional neutral shades but in a more dramatic setting. Hope you like, I had a lot of fun creating it!
Urban Decay Primer Potion Anti Aging
Urban Decay 24/7 Mushroom Eye Pencil
Urban Decay Naked 2 Palette: Chopper Eyeshadow
Urban Decay Naked Palette: Buck, Darkhorse, Virgin Eyeshadow
Sigma Declare Eye Pencil
Urban Decay Perversion Eye Pencil
L'Oreal Power Volume Collagen Mascara
Ardell Evil Queen False Lashes
Benefit Hoola Bronzer
Rimmel Pink Rose Blush
Urban Decay Naked Super Saturated Lip Pencil
Senna Cosmetics Wistful Lip Laquer
Be sure to check out my other Disney Villain looks: Queen of Hearts, Maleficent, and Ursula!


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CHECK THAT SWING — Oak Ridge Senior Cory Dela Cruz takes a shot at early March game against Union Mine. The golf teams faces new rivals this year in the Delta River League. Village Life photo by Pat Dollins
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Fricano's News
Nov 8, 2012
Fricano's Deli Weekly Newsletter.
Fricano's Deli Weekly Newsletter.
Today's Specials
Weekday specials
Monday: Curry Chicken Salad Sandwich
Tuesday: Call Us
Wednesday: Spicy Pesto Chicken Salad Sandwich
Thursday: Flyin' Hawaiian
Friday: Call Us
Call us for our
Saturday and Sunday
Daily Specials!
4:00 - 7:00
The Latest From Fricano's
Dec 15, 2015
Holiday Hours:
Monday 12/15 to Wednesday 12/23 11am to 7pm
Thursday 12/24 to Sunday 12/27 CLOSED
Monday 12/28 to Thursday 12/31 11am - 7pm
Friday 1/1 CLOSED
Saturday 1/2 to Friday 1/8 11am - 7pm
Saturday 1/9 back to regular hours
Monday - Friday 11am - 8pm and Saturday/Sunday 11am - 7pm
May 25, 2013
We will be closed Sunday May 26th and Monday May 27th for memorial day. Have a great weekend!


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Huffingtonpost: Portland Divests From Walmart
May 16, 2014 | Huffingtonpost.com-- Walmart and Portland, Oregon don't mix.
Portland Business Journal reports that on Thursday, Portland city officials announced it will not be making any more investments in the world's largest retailer and that the first of the city's Walmart holdings had expired.
Oregon's KOIN reports that the investment pullback came after Portland leaders determined the mega-retailer is "not a socially responsible company." Portland had about $36 million invested in Walmart, or about 2.9 percent of the city's investment portfolio. The city announced Thursday that it would be free of all remaining holdings by 2016. READ FULL ARTICLE


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The Samoa Law Reform Commission Team
The Commission is currently seeking feedback on its reviews. Click here to make a submission.
Australasian Law Reform Agencies Conference 2014
The Samoa Law Reform Commission was established in 2008 to facilitate the review, reform and development of the laws of Samoa, in order to promote Samoan custom and traditions, enhance the social, cultural, economic and commercial development of Samoa, and ensure that the laws of Samoa are kept in a modern state which meets the needs of Government and the community.
Read more…
Current projects
Pule a le Matai Sa'o
Civil Procedure Rules (Magistrates' & Supreme Court Rules)
Alcohol Reform


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Microsoft Security Report Shows Most Malware Infects by Deception
While exploit kits increasingly focus on using Java to infect computers, most attacks rely on deceiving the user, Microsoft said in its semi-annual Security Intelligence Report.Microsoft took aim at deceptive software in its latest semi-annual Security Intelligence Report, noting that the addition of two popular, but deceptive, programs to its malware-removal program caused a trebling of the company's malware detections in the fourth quarter of 2013. The report, released May 7, showed that the number of computers cleaned with Microsoft's Malware Removal Tool jumped to 17.8 systems per 1,000 scanned in the fourth quarter of 2013, up from 5.6 in the third quarter. The jump represents the largest quarter-to-quarter increase in the infection rate ever measured by the company and happened while there was little change in the proportion of computers that encountered an attack. The increase is largely due to Microsoft adding signatures for two deceptive programs, and the increase in ransomware programs, Holly Stewart, senior program manager of Microsoft's Malware Protection Center, told eWEEK. "While the use of deceptive tactics is not new, it dramatically increased in the second half of 2013," she said.
Deceptive downloads include programs that appear to install a benign utility or plugin, but instead load malicious functionality. Two main families of malware accounted for the massive increase in the fourth quarter, according to Microsoft, because the company added both the pre-existing programs to its Malware Removal Tool.
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Every Friday night, 5–9 pm
Half-price gallery admission for adults. Ages 18 and under are free!
Cash bar. Prices vary for Off the Grid food trucks.
Get your Oakland groove on at Friday Nights @ OMCA with Off the Grid food trucks, music, and more! Join OMCA every Friday for a family-friendly take on a festive night market, with the best in Bay Area curbside cuisine from gourmet food trucks, local beer, wine, and non-alcoholic beverages at the Blue Oak beer garden, live music, and dance lessons. Get creative at family-friendly drop-in workshops, learn from local foodies in the Makers & Tasters Series, and enjoy special guest performers and events. Enjoy unique programs, including:
- Makers & Tasters Series with local beer brewers, coffee roasters, organic farmers, and authors hosting talks, demos, and tastings on the first and last Friday of the month, from 6 to 8 pm. The Makers & Tasters Series will feature local vendors from Whole Foods Market the last Friday of each month!
- Live music, DJs, acoustic sets, and family-friendly dance lessons where you can shake it up with dances based on the weekly music themes.
- Family fun at Friday Nights: every Friday night, from 5 to 8 pm, features a free hands-on art workshop for all ages, and select Fridays feature storytime with the Oakland Public Library from 6 to 6:30 pm.
- A rotating list of food trucks, music themes, and featured artists. Check the weekly event listings on the right to find out more; like us on Facebook and follow us on Twitter for up-to-the-minute event updates!
Marketplace @ OMCA: local makers interested in selling artwork, handmade, and handcrafted works at Friday Nights @ OMCA should fill out our Interest Form
Reservations: Need a place to park during Friday Nights @ OMCA? Now you can reserve a picnic table or even the café terrace where your group can gather to join all the fun!
How to get here: OMCA is located one block from the Lake Merritt BART Station.
Parking: Event parking is available at the Museum Garage, with a $5 flat fee starting at 5 pm. The Museum garage closes at 10:30 pm. More information is available on our Directions page.
Garden Access: OMCA's garden and terraces are open and free to visitors during Friday Nights @ OMCA from March through November, with the exception of dates when the garden is rented for private events. More information on garden access.
Presented in partnership with Off the Grid: Lake Merritt @ OMCA. Friday Nights @ OMCA is made possible in part by generous support from Bank of America, the Oakland Museum Women's Board, The William and Flora Hewlett Foundation, and the Koret Foundation. Support for the Latin Salsa Music program is provided by the Zellerbach Family Foundation. Makers & Tasters Series sponsored by Whole Foods Market on final Fridays in 2015.


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Greater New York
Welcome to Jewish National Fund in Greater New York! JNF of Greater New York is as diverse as New York State itself. From the Empire State Building to the Hudson River to the shores of Long Island, JNF of Greater New York looks to engage, educate and energize New Yorkers and provide opportunities to make a difference in Israel.
Throughout its 109 year history, JNF has served as the source of strength for the Israeli community and in turn the Jewish community world wide. Whether it's replanting the forests through Operation Northern Renewal or creating new communities through Blueprint Negev , JNF is there to address the needs of the Israeli people, offering them a better quality of life and live safer and healthier lives.
We invite you to browse through our regional pages to learn more how you can be a part of the JNF family.
We look forward to having you join us! Thank you for your support of Israel and JNF.
Recent News
JNFuture New York Board Retreat
JNFuture New York Executive Board members on a retreat to to discuss...
New York Board and JNF Executive Forum member Steven Shalowitz Interview with CEO Russell Robinson
JNF CEO Russell Robinson was recently interviewed by The One way Ticket...
Judy Black and Richard Schlosberg hosted a JNF Lunch at their home in...
Greater New York Salon Speaker Series with Karmit Arbel-Rumbak
Karmit Arbel-Rumbak from Green Horizons enthralled the group in Manhattan...
Speaker Series Event Hosted by JNFuture and Lawyers for Israel Society
Greater New York JNFuture and Lawyers for Israel Society hosted a Speaker...
Upcoming Events
Please check back soon for upcoming events!
Get Involved
JNF has a lot to be proud of, but there's still a lot to do. Love what we do but not sure how you can help? Want to connect the next generation to Israel or plan a volunteer day? Have a new project idea?
Greater New York Regional Office Information
Serving: New York City, Long Island, Westchester, Fairfield, Rockland, Bergen, Sussex and Hudson.
Mailing Address
Maidelle Goodman Benamy, Executive Vice President, Greater New York
Log In
Regional Sponsors
Press Releases
El Paso Native Russell F. Robinson Named One of World's "50 Most Influential Jews"
JNF 2016 National Conference in NY Hailed as 'One of the Most Successful Ever'
JNF National Conference 2016 Opens in NY
Find us on:
Water Challenges
In Israel the most precious commodity is water and it is at risk. Find out how you can help.


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December 2012 President's Message
December 10, 2012 | Posted by admin
2 Comments
Winter is finally here in the Rockies! I sure hope we get more snow and colder temperatures than last year. It will have to get very cold very soon to keep 2012 from being the warmest year on record in the United States, and one of the driest too. Extreme weather events like drought in the Midwest and Hurricane Sandy in the East caused billions of dollars in damage.
The impacts of climate, weather, and extreme events on humans is an issue that I am sure will keep many of us water resources professionals busy for decades to come. AWRA meetings such as the recently completed Annual Conference in Jacksonville, Florida are great places to learn about the newest tools, techniques, and data sets that you and your fellow water professionals will be using to solve the climate related problems of the future.
The year has gone by too quickly and my time as AWRA President is just about finished. The reigns (maybe "rigging" would be more appropriate) of AWRA will soon be in the very capable hands of Carol Collier. I want to thank the Headquarters staff, the other Board Members, and all of you AWRA members for making this year fun, educational, memorable, and fulfilling. I especially want to thank my family for allowing me the time and giving me the support to participate in the many AWRA events that have keep me traveling the last two years (just one more year to go as past-President).
Finally, here is a brief summary of the November AWRA Board of Directors meeting. We heard about the status of upcoming conferences in St Louis, Hartford, Portland, and Beijing; received updates on AWRA's 2012 budget and membership; approved the program for a 2013 webinar series on IWRM; heard reports from task forces on: the Integrated Water Resources Management Certification proposal; State section relations, AWRA's 50th Anniversary, and the US Water Partnership. We also heard from Wiley-Blackwell, the publisher of JAWRA. The Board meets next for its 2-day strategic meeting in early February.
Bill Battagalin
AWRA president
2 Comments so far
John Wells on
December 13, 2012 4:11 pm
Thanks, Bill, for leading AWRA with such humor, thoughtfulness, and grace. Thanks to you its been a very constructive year, and fun to boot!
Michael "Aquadoc" Campana on
January 5, 2013 7:16 pm
Couldn't agree more with John! Thanks, Bill!


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A retroviral marker has been quantified in serum from patients with amyotrophic lateral sclerosis (ALS) but scientists say that it is still not clear what the virus is or whether it is damaging motor neurons.
A team of British scientists, led by Jeremy A. Garson, MD, PhD, of the University College London Center for Virology, developed a powerful assay to measure reverse transcriptase activity — a marker for the enzyme expressed by retroviruses — in serum and CSF. Fifty percent of the ALS patients had more than 6 x 10-8 units/mL of this enzyme activity in their serum compared to 7 percent of healthy controls, according to the report in the Jan. 22 Neurology. Project ALS, a nonprofit philanthropy that supports ALS research, funded the study.
If scientists can identify a viral cause, "it absolutely opens us a whole new door to treatment," said Kenneth Tyler, MD, the Ruler-Lewin Professor of Neurology at the University of Colorado, in a telephone interview with Neurology Today.
Dr. Tyler, who was not involved in the study, said: "Dr. Garson's group has developed an improved assay for reverse transcriptase that could help scientists identify viral activity. These studies continue to provide intriguing evidence that an unidentified retrovirus may have some role in the disease."
In 2000, Dr. Garson and his colleagues screened for the enzyme in a small sample of British ALS patients and controls — using an older assay that measured the presence of reverse transcriptase activity — and found that a much higher proportion of patients expressed serum reverse transcriptase than did healthy controls.
In 2005, Dr. Garson and Ammar Al-Chalabi, MD, of Kings College in London, had replicated similar findings in American ALS patients, including samples from the Harvard ALS team, led by Robert H. Brown Jr., MD, PhD.
But with the new assay, investigators could use the molecular biological technique — real-time polymerase chain reaction — to measure the amount of DNA that the reverse transcriptase present in the patient's serum can synthesize from RNA in a period of 90 minutes.
"In the new study, we could quantify the amount of reverse transcriptase activity present in the blood of ALS patients and compare it to the amount present in the blood of patients infected with HIV," Dr. Garson explained. In addition, the new study looked at CSF for the first time and also at the novel human gamma retrovirus — xenotropic MuLV-related virus (XMRV) — that had not yet been discovered in 2005.
The idea that a virus can damage motor neurons is not new. Decades ago, it was clear that poliovirus had a special affinity for anterior horn cells but there was no convincing evidence that survivors of poliomyelitis were at increased risk for ALS.
Joseph Berger, MD, and his colleagues at the University of Kentucky at Louisville reported in a 2006 paper in the Journal of the Neurological Sciences that symptoms similar to ALS in AIDS patients disappeared with anti-retroviral therapy. Also, scientists have used retroviruses in animals to reproduce motor neuron damage and ALS symptoms. These same retroviruses trigger an increase in lymphomas, according to a 1997 report in Neurology.
These findings — plus a 2006 report online in the Pubic Library of Science Pathology of a newly-identified XMRV found as yet only in some men with prostate cancer — prompted Dr. Garson and colleagues to determine whether they could replicate their findings in another cohort of ALS patients. They wanted to determine whether XMRV might be the elusive virus.
Dr. Garson tested 22 blood samples and 25 CSF samples from ALS patients — mostly supplied by Dr. Brown's group at the Massachusetts General Hospital. Investigators also obtained serum from two patients with HIV from hospitals in London.
The samples were sent to the British investigators who were blinded to the sample sources. The ALS patients had no family history of motor neuron disease.
Fifty percent of the serum samples from ALS patients contained reverse transcriptase — greater than 6 x 10-8 units/mL — compared to 7 percent of the controls. The levels in the ALS patients matched those measured in samples from the HIV-infected patients. Only one of 25 CSF samples tested positive for reverse transcriptase, and it was from an ALS patient. The scientists concluded that serum is the better fluid to look at for reverse transcriptase activity in the future.
But why didn't the investigators find reverse transcriptase activity in all patient samples? "The level of serum RT activity in some ALS patients may fall below the lower detection limit of the current assay," the investigators said. And, "there may be a proportion of patients with sporadic ALS in whom the disease is not associated with serum RT activity because different pathogenic mechanisms may be involved."
The retrovirus, however, remains elusive. The serum and CSF tested negative for XMRV.
So that brings scientists back to the vexing question: Can viruses cause ALS? "As new viruses emerge, this question gets re-explored," Dr. Tyler said. "For a disease with limited therapeutic options, this is an important line of research."
Over the years, scientists have looked for evidence of known viruses, such as polio, as a trigger for human sporadic ALS. The identification of retroviruses in human disease has sent a new generation of virologists back into the laboratory. Retroviruses do not follow ordinary rules of genetics. They possess an RNA genome and replicate through a DNA intermediary to survive in a host. And they do this through reverse transcriptase.
While the most famous retrovirus is HIV, there are many others that may be involved in human disease. Some have been linked to cancers and autoimmune diseases but many just invade the genome and appear to do nothing.
"It's an unexplored field," Dr. Tyler explained. What's more, there is evidence of endogenous human retroviruses that may have piggybacked on to the human genome.
"The problem is where we go from here?" said Dr. Brown, a professor of neurology at Harvard Medical School. He is a co-author on the Jan. 22 Neurology paper, but gives sole credit to the British investigators for the finding.
"It makes the story solid enough and worth figuring out what the retrovirus is," Dr. Brown said. "But the process of going from the source of enzyme activity to the actual virus producing that activity is extremely labor-intensive. Scientists can work for many years and find nothing. Of course, the dream would be that something could be identified like the HIV virus that causes AIDS."
If there were a retrovirus in the blood, would anti-viral therapy work? These treatments have not yet been rigorously tested, but Dr. Brown said doctors at Beth Israel Medical Center in Manhattan tried retroviral therapy in a small group of their ALS patients and the treatment didn't show much effect. The damage may have already been done, Dr. Tyler added.
The next step in unraveling a viral theory for ALS, experts agreed, is to attempt to isolate and identify the mysterious retrovirus.
✓ Fifty percent of ALS patients had more than 6 × 10−8 units/mL of a marker for a retrovirus — reverse transcriptase enzyme activity — in their serum compared to 7 percent of healthy controls, according to a new study.
©2008 American Academy of Neurology
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Odds & Ends Again
Cozy Store with Ten Rooms to Explore!
At Odds & Ends Again, you will find a unique assortment of home furnishings and decor. We help families liquidate their estates and bring the best items to the store for you!
Our ten rooms each take on unique personalities as our inventory evolves, and holidays come and go. You'll will find an ever-changing treasure hunt for one-of-a-kind tables, chairs, lamps, dressers, bookcases, kitchen and serving wares, vases, art, jewelry, glassware and general decor. With both antique and contemporary merchandise from hundreds of homes and new items coming in every day, many of our regular shoppers claim that the experience is "new every time!"


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Tuna Fish Salad on a Bed of Lettuce
Total Time
Prep 8 mins
Cook 0 mins
This is one of my favourite comfort foods, and is healthy too. It's usually gone within a day, and there seems to be plenty of it going around too.
Ingredients Nutrition
- 6 lettuce leaves
- 1 (6 ounce) can tuna packed in oil
- 1 large celery rib, chopped
- 1⁄3 cup green pepper, chopped
- 1⁄4 cup green onion, chopped
- 3 tablespoons mayonnaise (your favourite brand will do)
- 1 pinch salt and pepper
- 1 teaspoon oregano
- 1⁄4 cup olive, chopped
- 1 tomatoes
- Put the pepper, celery and green onion in a blender or food processor, and grate finely.
- Add the Tuna fish and mayonnaise, and pulse twice.
- Add the seasonings and pulse two more times.
- Line the lettuce leaves on a medium sliced plate, and spoon the tuna fish mixture in the center.
- Cut the tomatoes into round slices and put it around the tuna fish. Sprinkle the chopped olives on the tomatoes.
- Conversely, you could makes this into a sandwich, using torn lettuce leaves. Leave out the tomatoes and the olives if desired. Makes for a filling mini-meal and for good leftovers.
Most Helpful
Nice tuna salad. I had to use red pepper as I was out of green and omitted the olives for personal preference. This made a simple and tasty sandwich. Thanks Studentchef for a nice lunch. Made for Went to the Market Tag.
This was good. I was surprised by the nice flavour of the oregano and black olives in this. I made the mixture into little wraps of cos lettuce leaves chopping each ingredient small. But I left out the green pepper as a preference and used canned black olives for the olives. I would make these again trying a toothpick to keep them together and maybe add a squeeze of lemon.
Wonderful sandwich. I especially liked the addition of the black olives and oregano.


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I was a big fan of uTorrent on Windows, and since I moved to Mac I missed it a lot. I started using Transmission but what I really missed was the possibility to start a download as soon as a new item appear in a RSS feed. But the wait is over: I just received an email announcing the release of the beta version of uTorrent for Mac. I've to wait this evening when I get back home to install it on my Mac, but on LifeHacker I found a a screenshot of it. Technorati Tags: uTorrent,mac
A few months ago VMware released the first beta of Fusion 2, the first version of Fusion to add multiple display support.
Today they released the beta 2: Safer, Stronger, and More Seamless: VMware Fusion 2 Beta 2 Now Available.
I'm using Fusion2 beta 1 since a month or so, and I'm really enjoying using VS on my Cinema Display.
The only problem I found is that the shared folder shows up as network folder, not as native disk inside Fusion, so I cannot run ASP.NET apps from it due to security reasons. In XP it was just a matter of increasing the...
Since I installed Win2008 on my Mac I never really used it: turning on my company's laptop was less painful than the usability problems that both VMware and Parallels have. VMware was not working very well with more than one display: if you open an application in Unity mode it will be stuck in the display the main Fusion application is running, and in fullscreen mode it is not possible to have more then one display. Parallels works fine with multiple displays, but I don't like the way the mouse pointer is handled in Coherence mode: there are...
After reading Damien's post about his Win08 Server installation on his MacBook Pro I decided to try and do the same on my MacBook (without the "Pro").
Since I made the switch to the Mac I always did my little home coding on my old laptop or on my work ones, but now I decided to do more coding and less writing and I prefer to do it at my desk on my 20" Cinema Display, so I need to run Visual Studio on my Mac. Here the need to install Windows.
Setting up Windows 2008 Server on the Mac with Boot...
Today a new psychological condition is born: Pre Mix Envy.
A new condition for developers who want to be in Vegas but can't.
It was coined by Chris Hayuk, a British .NET developer and Silverlight blogger that can't go to the MIX08 event that is starting in a week in Las Vegas.
I would have been to the event as well, and hear from the mouth of ScottGu all the cool announcements that they are going to make (ASP.NET MVC vNext, Silverlight 2.0, IIS7, IE8 and so on), but I guess I'll have to stay up at night and watch the...
It's already almost 2 months since I got my Mac and, while all other switcher installed a virtualization software as first thing, I'm still running on Leopard only. Probably because I still have 2 other laptop running on Windows at home (my old one and my work one). But sooner or later I've to do it: but I've not decided yet what to install. I'm leaning a bit toward Fusion. I found a very complete benchmarking that says Parallels is better than Fusion (even though Fusion is faster hosting Vista), but it compared Parallels 3.0 with Fusion 1.0...
On today's online edition of The Globe And Mail, a Canadian national newspaper, in their selection of "RECOMMENDED LINKS: BETTER I.T. IN 10 CLICKS OR LESS", they included also my post about the 18 applications for Mac.
Make Macs useful
Last week's Macworld Conference & Expo showcased a lot of new Apple products, including its superlight and thin MacBook Air laptop computer. In most companies, however, IT departments stick to Windows-based machines, but Simone Chiaretta may be able to change that.
MsMr. Chiaretta, an Italian .Net developer, recently published "18 (almost) free applications" for the Mac, which includes text editors, FTP...
A bit more than 2 weeks passed since my post with some considerations on the Mac applications available and I had a bit more time experimenting and reading some advices from other and I think I almost decided my toolbox of must-have applications, so here I'm sharing my list of apps Read More...
If you are like me and you followed the live coverage of the MacWorld 08 keynote you might have already seen it, but if you missed the live announcement of the MacBook Air, there is a nice offer going on at MacHeist: they are selling a bundle of 11 Mac apps, priced $368,75, for just $49.
Among the many apps, I want to highlight the one I'm interested in:
1password. a password storage app integrated with all the browsers available on the Mac
CoverSutra: a iTunes controller
AppZapper: uninstaller for the Mac....
One of thing I'm doing these days is to try and keep all the 35.000 email I received and sent in the last 10 years. So I looked at how to move the contents of my pst files to the standard mbox mail format.
Looking on the web I found a quite interesting explanation on the Microsoft KnowledgeBase:
ENT2001: How to Use IMAP to Move Messages Between a PC and a Macintosh in Entourage, Outlook, or Outlook Express
What the KB article says is that you just have to create an account on an IMAP mail server, configure both clients to get emails...
Here is a funny picture I just took off my digital camera: all my ice climbing tools, hanging drying with my clothes This is also a test of Ecto 3 beta: after my post of yesterday about my thoughts on the applications available on the Mac, I exchanged a few emails with Adriaan Tijsseling, the developer of Ecto, and he was very nice, and immediately released a new build (b20) that fixed the problem with the categories not being downloaded (actually it was a problem in Subtext MetaWeblog API implementation, that is missing the method blogger.getUserInfo). He also pointed...
It's now a week since I started using my Mac and I wanted to share some random thoughts:
The MacBook trackpad... WOW... it's the way trackpad should be: if configured correctly you can right-click, left-click, double-click, drag&drop and scroll (both horizontally and vertically) using only the touch surface, no need to use the only button: the most usable trackpad I ever used
I'm trying to use for all my day to day tasks (reading email, browsing, chatting, blogging, reading feeds, editing HTML and text, and so on) native Mac applications, so I've...
If you are like me and just bought a Mac coming from ages of Windows you might be having an hard time loosing all your habits and learning to walk again.
Today I found a reference to a post of one year ago that compared how the easy things are done on a Mac and on a PC: things like what the "Apple" key is used for, why when you click on the "X" in the application bar the window is not closed but only "hidden", why there is no "Delete" key, how to install an app, and so on.
With October approaching, Apple released to the developers subscribed to the early access program a build that is said to be the first in the Release Candidate cycle, aiming at the Golden Master build by the end of October. And together with this release, the Microsoft's Macintosh Business Unit announced the release date and the pricing for the next version of Office for Mac: Office:mac2008. The standard version, with Word, Excel, PowerPoint and Entourage with support for Exchange will be sold at US$ 400. But if you don't need to connect to an Exchange server you can save more than 50% of the...
Among the other announcements at the WWDC (and a new slightly different graphics for their site), the most unexpected one was about the release of the new version of Safari for Windows: claimed to render HTML 2 times faster than any other browser, for sure will make life easier for web developer that have to test their work on Safari (even if probably now web developer are already running on OS X). Here are some screenshots: Installing Safari Safari icon on Windows Safari about window:running over my CCNET Monitor gadget...
This is the blog of Simone Chiaretta, an Italian .NET developer, architect, ex-Microsoft MVP, ASPInsider, Subtext core member, ASP.NET MVC lover with a passion for triathlon.
Want to know more? Keep reading...
I also wrote a few books about ASP.NET MVC.
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brianne_marie911@ wrote:
I thought the the move "The 13th Warrior" was a great movie. It help me with my Report. Which was great.
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The Bike More Challenge is a challenge to new and existing riders alike: how many people can we get to #bikemore during the month of May?
The Challenge is now over, but you can continue to record your rides on this site.
Let's show more people in Oregon how easy and enjoyable riding can be!


text:
Detection of Fusarium oxysporum DNA and (1-3)-b-D-glucan in serum specimens of experimentally infected mice
Abstract number: 1733_1471
Khan Z.U., Ahmad S., Theyyathel A.
Objective: Invasive Fusarium infection is an emerging opportunistic mycosis associated with high mortality. Its diagnosis is difficult due to non-specific signs and symptoms and similarity in tissue morphology with Aspergillus species. The aim of this study was to develop a sensitive and specific diagnostic procedure based on amplification of Fusarium oxysporum DNA by nested (n) PCR and to compare the results with (1-3)-b-D-Glucan detection in serum samples obtained from experimentally infected mice.
Methods: Sixty mice immunosuppressed with intraperitoneal injections of cyclophosphamide were infected intravenously with a dose of 1×107F. oxysporum conidia/mouse. Six mice were sacrificed every day post-infection. Blood specimens were collected by cardiac puncture. One hundred mL of blood was used for culture and the rest was processed for separation of serum. The lung homogenate was cultured and was also used for direct microscopic examination. The genomic DNA from the reference strains of F. oxysporum and 9 other fungi including Fusariumsolani, Aspergillus fumigatus, A. flavus and A. terreus was isolated and used as template for nPCR specificity. The species-specific primers were derived from the internally transcribed spacer (ITS)-1 and ITS-2 regions of rDNA and their specificity was confirmed by BLAST searches. The DNA from serum specimens was extracted using standard procedures. The PCR amplicons were detected by agarose gel electrophoresis. The (1-3)-b-D-Glucan was detected by Fungitell (Cape Cod Inc. E. Falmouth, MA, USA).
Results: The nPCR was specific for F. oxysporum and detected nearly 440 fg of Fusarium DNA which is roughly equivalent to 10 genome copies. Of the 60 serum samples tested, 55 (92%) were positive for (1-3)-beta-D-Glucan and 47 (78%) were positive for F. oxysporum DNA. The lung homogenates of all the infected animals yielded F. oxysporum in culture. The fungus was also discernible in KOH-calcofluor mount of 40 (67%) of the animals.
Conclusions: A sensitive and species-specific nPCR assay has been developed for the detection of F. oxysporum DNA in serum samples of experimentally-infected mice. During a follow-up of 14 days post-infection, 92% and 78% of serum samples were positive for (1-3)-b-D-Glucan and F. oxysporum DNA, respectively. The data suggest that detection of F. oxysporum DNA by nPCR combined with (1-3)-b-D-Glucan may help in early diagnosis of invasive fusariosis.
Supported by KURA Grant MI 04/02.
Session Details
|Session name:
|European Society of Clinical Microbiology and Infectious Diseases
|ICC, Munich, Germany
|Presentation type:
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Ressentiment Redux
I really do want to reserve this space for proper rants, but since the post on ressentiment from last week has prompted a broader reaction than I anticipated, I'm going to violate my general rule and let a more serious—and therefore somewhat more boring—argument slip in. I promise not to let it happen too often.
First, to clarify the original thought a little. When I say that the modern populist right is animated by ressentiment, I'm not claiming it's composed of people who are somehow jealous of, I don't know, Nancy Pelosi or New York Times reporters, and want to be just like them, which would be silly. The dynamic I'm imagining looks very different—I'll sketch it a little further on. More importantly, I don't mean this as some kind of Mannheimian "unmasking" where I diagnose the subconscious psychological reasons people hold some disfavored set of political views, thereby supposedly robbing them of their force. ("You only advance this argument because it's in your economic interest/you hate America/mommy didn't breast feed you/whatever.") To the extent we're talking about the economic issues currently center stage, I'm in substantial agreement with plenty of the explicit political principles of the movement I'm describing. That is, I don't think it's ressentiment that causes people to adopt conservative values or policy positions. This is not the What's the Matter With Kansas argument; it's about how people organize in defense of their political values, not their reasons for holding them. If anything, my worry is that the motivating impulse is not interestingly related to conservative values.
What do I mean? Well, it's a core conservative insight that communities—and certainly political communities—are defined as much or more by implicit practices and ways of life as by explicit points of doctrine. The most basic level of any political group's ideology is always necessarily outside the ideology, because in the wild the explicit principles need to be supplemented by implicit rules of action—practices as opposed to propositions—that tell you how to apply, weigh, modify, and for that matter just identify the important articulated principles that define the movement. Logic geeks may think of Lewis Carroll's dialogue "What the Tortoise Said to Achilles" here; philosophy geeks may insert their favorite Alasdair McIntyre quotation. There's conservative ideology, and there's the distinct question of how it's acted out or advanced by a particular group of human beings in a particular time and context.
The trick in a pluralistic democracy is that you also need embedded background rules and practices that make the national-level political institutions run. If it really is a pluralistic and free society, these won't be part of some kind of thick monoculture, but embedded in the diverse lifeworlds of the people and groups in the polity. Rawls would have called these "comprehensive conceptions of the good," but that connotes something a bit too abstract and theoretical—the conceptions are embedded in ways of life, not just lists of explicit tenets or propositions. The clever alchemy of liberal democracy is to transform this potential source of conflict into an advantage through public deliberation, which (when it's functioning) gives us collectively a broader pool of perspectives and truths and insights to draw on. But in a very practical way, especially in our electoral system, broad political movements also need to create shared identities that bind together large coalitions and mobilize them to action. The binding element can be something perfectly pragmatic: "We are the small-businessmen who will be put upon by this tax hike." This works, albeit highly imperfectly, to the extent that the mechanism that pulls people into political engagement has as its upshot a motivation to persuade other people to agree with you about the best policy. If I favor school vouchers, I might emphasize to religious folks that they will make it easier to get their children a religious education, even if I don't myself consider this much of a benefit, because the point is agreement, not an articulation of my full cultural worldview.
One aspect of the problem with our current politics, I want to claim, is that the political identity of the populist right is too thick. We long ago grew accustomed to this sloppy use of "community," where we'll talk about the "medical community" or the "gay community"—even though this is clearly a kind of nonsense above the level of a smallish town. But national-level political communities really are communities now, in a fairly robust sense. Between dedicated cable and radio channels and the Internet, you really can live in them in a pretty literal and immersive way. But simultaneously—and maybe this sounds a bit paradoxical—political communities are therefore also more culturally autonomous. That is, they need no longer refer to something outside politics. When I enter politics as a small businessman or a Catholic or a philosophical conservative, I'm bringing information from outside the political process into it. What's really pernicious about a politics of ressentiment is that it cuts that tether—it enables a political identity that's generated and defined by political conflict itself. When Joe Trippi talks about the implosion of the Dean campaign, he says that one problem was that the internal community between supporter that any political movement needs became an end in itself, a way of satisfying social needs exogenous to politics, rather than a means to an electoral goal. Bringing other people onboard was less important than enjoying internal fellowship. The issue in each case was the way a particular group functioned, not any deep connection to the set of political ideals the group was nominally working to advance.
So that's the general worry—a populist right animated by ressentiment isn't going to do a good job of injecting conservative ideas into deliberation in a useful way. This is not, just to be clear, some kind of white-gloved complaint about "tone," because really, fuck tone. The ascendancy of angry bluster isn't the problem; it's a symptom. The problem is what the anger obscures. Maybe sex is a good analogy here: If you're not turned on or emotionally engaged, it can look kind of ridiculous. Charging up the rhetoric prevents the kind of emotional distancing that would make the cultural grievances seem absurd, at least as politicial issues. I think progressives have to own their share of this, by the way: Part of the problem is that politics is no longer seen as a narrow tool for addressing some well-defined set of problems, but a kind of all-purpose machine for the satisfaction of human desires. Eating arugula falls under "interstate commerce" right?
As for the specific claim that the populist right is currently animated by ressentiment, I don't think this is a matter of excavating hidden drives from the subconscious; I'm talking about what's right out in the open. In fact, I want to suggest we need to read a lot of our current political rhetoric more literally and less symbolically. When Fox anchors make fun of Barack Obama's choice of fancy dijon mustards, or the way he pronounces "Pakistan," or say he's "apologizing for America," we naturally read these as coded claims about something else—as implying effeminacy and insufficient toughness for a commander-in-chief, or a class divide that shows he's out of touch the concerns of ordinary workers, or an inability to project strength in foreign affairs. I want to suggest that we take them absolutely literally: This guy eats different mustard than you do, pronounces words differently than you do, and doesn't share your affection for national symbols. The coded meaning is actually a red herring—it's just there to obscure the fact that the surface message is the one that matters.
We don't need to do some kind of probing psychoanalysis, because this stuff isn't subtext; it's text. Remember Palin's infamous "death panels" post? It wasn't just a claim that the government would deny care; the fear was that this was Obama's "death panels" getting to decide how worthy you are. Liberals treated it as a generic argument about "rationing," but by its own terms it was an argument about being judged. Conservatives' favorite photo of Obama has him with his nose in the air looking down on the hoi polloi, testifying to his purported arrogance. Then the outrage over a strained reading of an Obama remark about "putting lipstick on a pig": He's calling Sarah (and therefore you!) a pig! The message is pretty insistent: They think they're better than you. It's not, again, that I'm asking why people hold certain policy views and concluding that it's really about this kind of cultural resentment. I'm asking why the political coalition organized around this set of views is putting so much emphasis on this frame, and whether it isn't ultimately a bad idea to.
Maybe because I write a lot about technology and media, I'm biased toward an account of where this is coming from that stresses those changes. When people want to talk about how television changed politics, they invariably cite the Kennedy/Nixon debate, where folks who heard it on the radio thought Nixon won, but those who watched it favored Kennedy. The effect of a media form, however, may depend significantly on the degree of media saturation: We don't just see the official debate and a few news clips in the months before the election. We see national political figures constantly—and maybe we're even Facebook friends or Twitter followers. And when they appear for those big-ticket events, we're often networked with fellow-travelers in realtime dissecting every gesture and expression. It seems to be offline now, but recall Jon Chait's New Republic piece about hating George Bush? That smirk! That swagger! The way he mangles English! The visible and audible signifiers of group membership loom much larger. At the same time, demographic clustering is probably increasing the correlation between political ideology and these other cultural markers.
It's a bit of a truism that new transit technologies always have their greatest transformative effect on those who were previously at the periphery. If you sat in on the media and tech forums at the last CPAC, this was a source of great excitement: Liberal elites used to hold all the levers of media power, and the great boon of the Internet for the right is that they now have a way of bypassing Hollywood and New York. So no big surprise that a lot of what's initially released will be tinged with previously suppressed resentment about not having that media power, about being immersed in an alien-seeming media stream where the image of who's glamorous or cool or important or serious doesn't match your friends, and the admissible moves in the public conversation don't sound like your conversations. People have read racial undertones into the rallying cry "I want my country back!" and its cognates—probably because this is a strange way to present opposition to a policy agenda, however misguided you might find it. The instinct is right, but I think the conclusion is wrong: Race—and communism, as Tim Curry would remind us—is another red herring. What we're seeing is the natural sentiment of people who think of themselves as quintessentially American looking at an American popular and public culture that presents them as marginal. Palin or Joe the Plumber reintroduce to politics the promise of reality television: You too can be a celebrity—if not personally, at least by proxy!
Quite apart from its poisonous effect on deliberative politics, it's actually striking how un-conservative this is. There's a potential strategic benefit for any political movement in tapping these sorts of thicker grounds of solidarity, but the way it elevates and expands the scope of political identity—and therefore of politics—seems like it ought to be anathema to conservative principles. All the spheres of life government must not invade, they're voluntarily steeping in politics. It's just another way of living in Washington' s shadow.
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[...] This post was mentioned on Twitter by Julian Sanchez, True/Slant Coldcocke. True/Slant Coldcocke said: Ressentiment Redux http://tinyurl.com/yl4coaa @trueslant [...]
[...] UPDATE #3: More Sanchez [...]
[...] to unify his animus and project it away from him. In that way, The Dish mirrors the contemporary conservative movement, the sight of which appalls him. Possibly related posts: (automatically [...]
[...] Julian Sanchez: But national-level political communities really are communities now, in a fairly robust sense. Between dedicated cable and radio channels and the Internet, you really can live in them in a pretty literal and immersive way… What's really pernicious about a politics of ressentiment is that it cuts that tether—it enables a political identity that's generated and defined by political conflict itself… [...]
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Maida Heatter's Coconut Layer Cake
2 1/2 cup s
sifted cake flour
1 tablespoon
baking powder
1/4 teaspoon
1/4 pound
(1 stick) butter
1 teaspoon
vanilla extract
1 1/2 cup s
1 cup
large orange, zest finely grated
A few spoonfuls melted, strained apricot preserves
Fluffy White Icing:
egg whites
1 1/4 cup s
light corn syrup
2 tablespoon s
2 1/2 cup s
Confectioners' sugar
pinch salt
1 teaspoon
vanilla extract
1/4 teaspoon
almond extract
8 ounce s
(3 to 4 cups) grated, toasted coconut (8 - 10 ounces)
Cake:A few spoonfuls melted, strained apricot preserves
2 1/2 cup ssifted cake flour
1 tablespoonbaking powder
1/4 teaspoonsalt
1/4 pound(1 stick) butter
1 teaspoonvanilla extract
1 1/2 cup ssugar
1 cupmilk
1large orange, zest finely grated
Fluffy White Icing:pinch salt
4egg whites
1 1/4 cup slight corn syrup
2 tablespoon swater
2 1/2 cup sConfectioners' sugar
1 teaspoonvanilla extract
1/4 teaspoonalmond extract
8 ounce s(3 to 4 cups) grated, toasted coconut (8 - 10 ounces)
- Preheat the oven to 375°F. Adjust the rack to the center of the oven. Butter 2 (9-inch) round layer-cake pans. Line the bottoms with parchment paper. Butter the paper and dust all over lightly with flour. Set aside.
- Sift together the flour, baking powder, and salt and set aside. In large bowl of electric mixer, beat the butter to soften a bit. Add the vanilla and sugar and beat for a few minutes. Add the eggs and milk and beat until smooth. On the lowest speed, add the dry ingredients in 3 additions, scraping the bowl with a rubber spatula as necessary, and beating only until smooth after each addition. Remove from the mixer and stir in the orange rind.
- Divide the batter between the prepared pans. Tilt and shake the pans gently to level the batter. Bake for 25 to 30 minutes, or until the cakes come away from the sides of the pans and tops spring back when lightly touched.
- Remove from the oven. Let stand for about 5 minutes. Cover with racks or cookie sheets and invert. Remove pans and papers. Cover with racks and invert again to cool right side up.
- When the layers have cooled completely, place 4 strips of waxed paper or baking parchment around a cake plate, and place 1 layer on the plate, upside down. Spread with a thin layer of smooth preserves, reserving some for the second layer.
- Make the Fluffy White Icing: Mix all of the ingredients except for the vanilla and almond extracts in the top of a large double boiler; it must have at least an 8 to 10-cup capacity. Place over hot water on moderate heat. Beat with an electric mixer at high speed for 5 to 6 minutes, until the mixture stands in peaks when the beaters are lifted. Immediately, in order to stop the cooking, transfer to the large bowl of an electric mixer. Add the vanilla and almond extracts and beat at high speed for about 5 minutes more, scraping the sides and bottom of the bowl almost continuously with a rubber spatula, until the mixture is smooth and very thick. Use immediately.
- Spread a third of the icing on the bottom layer. Sprinkle with a third of the coconut. Put on the second layer, right side up, so that the 2 cake bottoms meet in the middle. Spread the top with the remaining apricot preserves. Use another third of the icing to ice around the sides of the cake. Use the remaining third of the icing to ice the top of the cake. Quickly spread with a long, narrow metal spatula to smooth the top and sides.
- With the palm of your hand, press another third of the coconut onto the sides and sprinkle the remaining coconut evenly over the top. Remove the paper strips, pulling each out by a narrow end.
About this Recipe
My dear friend Maida Heatter made me the best coconut layer cake ever when I visited her for my Food Network TV show. As Maida says, "Fresh coconut, freshly grated, is a rare treat. If possible, use it. Fresh coconut is moist. If you use canned coconut, use the moist type and the most finely shredded." This recipe comes from her acclaimed "Maida Heatter's Book of Great Desserts" (Andrews McMeel, 1999) and appears here with her kind permission. Thank you, Maida!


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While it's not quite NSFW, D3 Publisher will get you some strange looks from passing co-workers (It's for work Eugene Morton! Wooooork!) with their anime-girl-infested music game Dream C Club. Found in the pile of Xbox 360 media that Microsoft put out at it's spring showcase, rest assured Japanese Xbox 360-owners seeking a PG-rated Japanese hostess bar simulator will have... (struggling here) um... options this summer.
Well then as for the girls, Reika... yeah I'm more of a purple hair kinda guy, myself. WTF Japan!
Dream C Club Japanese Spring Showcase Trailer


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Story Details
Governor asks Utahns to Join Connecticut in Moment of Silence
Dec. 21, 2012
What: Governor Dannel P. Malloy of Connecticut has declared Friday, December 21, as a Day of Mourning. He is asking all citizens of Connecticut to observe a moment of silence at 9:30 AM for the victims of Sandy Hook Elementary. Places of worship and government buildings, which have the ability, are encouraged to ring bells 26 times, representing each of the 26 victims. Governor Malloy invited other states to observe the moment of silence at 9:30 AM, in their own time zone.
Governor Gary R. Herbert invites all Utah citizens to observe the moment of silence. In addition, he has authorized the Capitol bells to ring 26 times. The bells will then play one of Emilie Parker's favorite songs, "Angels we have Heard on High."
When: Friday, December 21, 2012 at 9:30 AM
9:30-9:31 AM Observe moment of silence
9:31 AM Capitol bells will ring 26 times, representing each of the victims
9:33 AM Bells will play "Angels we have Heard on High," one of Emilie Parker's favorite songs
Visual: The Capitol with the bells ringing.


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In her celebration of the beauty of food, artist Sarah Fairchild creates large fluorescent images of plants — primarily vegetables — grown in the Midwest.
She renders subjects such as Brussels sprouts, cabbages and corn in pinks and magentas.
Her "electric" plants, she said, "hover against swirling, metallic and iridescent backgrounds, which stand in contrast to the seemingly pedestrian subject matter."
Her works recall the wallpaper designs of artists such as William Morris and Charles Burchfield.
"Lush: New Works by Sarah Fairchild" is on view through March 9 in Hammond Harkins Galleries, 2264 E. Main St., Bexley.
An artist's talk will begin at 2 p.m. next Sunday in the gallery.


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Looking for a code or standard for your tablet? Need a code in app or eBook format? NFPA Mobile is the place to find our growing library of mobile products. With the wide array of smart devices out there, NFPA gives you one spot to find links to the products you need on the go.
With our big announcement a few weeks ago, you can now get mobile-friendly eBooks in DRM-free PDF format for any of our products in the catalog. This is a nice, versatile format that is compatible with any device that can read a PDF.
If you'd rather have an app, we've got a selection of titles in both the Apple and Android app stores. NFPA codes and standards are also available as dedicated eBook files for the Apple, Kindle and Nook platforms. You'll also be able to find links to the apps right on the NFPA document information pages. Take a look at the NFPA 70: 2008 (NEC) page or the NFPA 70E: 2012 page.
Mobile access is a core goal for 2012 and 2013. We've taken a big step forward with the PDF eBooks, and will continue to grow our dedicated and solutions-based mobile products. So add the NFPA Mobile page to your bookmarks and keep an eye out for new easy-to-use and purpose-built products that go beyond the code in the coming months.


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Jennifer L. Castle
Magdalen College, Oxford, OX1 4AU
I am a tutorial fellow in Economics at Magdalen College, Oxford University, and a Research Fellow at the Institute for New Economic Thinking at the Oxford Martin School.
My research interests lie in the fields of model selection, forecasting, time-series econometrics and applied macro-economics. My research focuses on econometric modelling and the use of general-to-specific methodology in modelling economic time series, modelling non-linear economic time series and macro-economic forecasting in theory and practice, with applications including inflation, unemployment and the output gap.
As a tutorial fellow in economics, I mainly give tutorials in macroeconomics, quantitative economics and econometrics. Tutorials are mostly held in groups of 1-2 students, with some classes for the whole year group. At the post-graduate level I teach courses in econometrics, as well as teaching on econometrics summer schools focusing on the use of OxMetrics software in econometrics.
I studied economics at Durham University, before moving to Nuffield College, Oxford University, where I obtained my M.Phil and PhD in Economics. My doctoral thesis examined empirical modelling and model selection in a non-stationary world, and I jointly held an ESRC research grant on Automatic Tests of Model Specification during my PhD with Professor David F. Hendry. I was awarded a three year British Academy Postdoctoral Research Fellowship at the Department of Economics and Nuffield College, Oxford University, investigating the selection, specification and testing of non-linear models, prior to joining Magdalen College as an Economics Fellow in 2009. I am a James Martin Fellow at the Institute for New Economic Thinking at the Oxford Martin School, University of Oxford, and I am on the Board of Directors of the International Institute of Forecasting.
My curriculum vitae is available here.


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Thumbnail Index
Charlie McCoy, Barbara Mandrell and Roy Clark.
(May 17, 2009)
(AP Photo)
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License Agreement.
Tickets for dates listed may not yet be on sale. Dates may change without notice.


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Dear Beloved Customers,
It's that time of the year again when lights shine on the streets, abundant food are on our tables, little kids open their gifts and families are reunited after a long time. Oh, how Christmas brings joy to our hearts. Just as this year has been good to you, we are thankful that it is the same for us in Philrealty. Please allow us to say Thank You for being part of our 2013 and being our inspiration in providing the best real estate services and properties for our customers all over the world. It's always a joy for us knowing that our clients have found their dream home through the services of Philrealty. If you are coming to the Philippines, we would gladly show you around our good listings based on your preferences and on your most convenient time.
So before your mailbox get flooded with other greetings, let us be the first one to greet you a Merry Merry Christmas and a Happy New Year! Let us always be thankful of what we have and know that it's always a blessing to give. May Jesus and His love be most importantly celebrated in this season.
From: Philrealty Global Marketing Inc & San Marino Builders
Website: www.philrealty-showroom.com
Website: http://www.philippinehouseconstruction.com
Email Add: email@example.com
Email Add: email@example.com
Telephone Number: +63-02-5208371
Merry Christmas from Philrealty!
Dear Beloved Customers,


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Black Pepper
In the world of spices, black pepper is king. Native to India, this age-old spice is used in almost every nation in the world to flavor meats, seafood, salads, rubs, sauces and much more.
For best flavor, buy whole peppercorns and grind them yourself. These reader recipes (shown at right and below) make the most of black pepper.
"I once had a recipe for Black Pepper Pound Cake from the early 1900's but lost it, so I adapted my grandma's pound cake recipe," relates field editor Sue Gronholz from Beaver Dam, Wisconsin.
"Louisiana Shrimp is a Lenten favorite at our home," notes Sundra Hauck, a field editor in Bogalusa, Louisiana. "I serve it right out of the roaster with corn on the cob and boiled potatoes.
Black pepper is prominent in Peppered Chicken Breasts from Jill Morzillo of Louisville, Kentucky. Yet it doesn't overpower the tender chicken flavor or the creamy mustard sauce. "It's easy to make yet elegant," Jill says.


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Wrong location?Change it here.
Place of origin: Wiesbaden, Germany
White Plains Road 10583 Scarsdale, United States
Market Street 10710 Yonkers, United States
Palisades Center NY 10994 West Nyack, United States
High Ridge Road 06905 Stamford, United States
Northern Boulevard 11030 Manhasset, United States
18,410 labels and 117,478 shops worldwide!
© 2016 by TLF LabelFinder GmbH


text: |Do you have what it takes for maximum home theater? With the HTP-620DV, you will. The VSX-D411 digital A/V receiver features Crystal digital signal processing and delivers 100 Watts to each of five channels. Dolby Digital 5.1 and DTS 5.1 surround sound processing provide spectacular decoding of movie soundtracks, and for "Party Mode", 5-Channel Stereo routes the full-frequency stereo signal to five speakers at full 100-watt-per-channel power. The slim-design DV-353 DVD player features exceptional audio/video processing and error correction, and it plays MP3-encoded discs. The five speakers (each with 3-inch piezo tweeter and midrange woofer and a high-frequency wave guide) and the self-powered 100-Watt subwoofer are all acoustically matched for optimal sound. A remote control is included.


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On teaching students how to code
Microsoft. Apple. Google. Facebook. Twitter. YouTube. Countless genres of music. The entire video game industry.
None of this would exist if it weren't for coders.
For the past few days, a viral video produced by Code.org has been making the rounds. In it, giants of the tech industry, athletes, and entertainers vouch for why students should be taught to write computer code in school. Take a few minutes to watch it below before I give my thoughts on the matter:
The structure of our current education system in the U.S. focuses on how the world was. History, reading-heavy English curriculums, and even the sciences emphasize our past. Obviously there is a place for such things to be taught, but not at the detriment of how to succeed in the modern world. Relevancy both gives context to the past while also providing students the tool set to understand how the things we interact with regularly work. In the information age we live in, the most relevant topic that the majority of the population has no knowledge of is coding.
As I said before the video, most of what we take for granted is a product of coders. Sure, these coders had to have the ideas in the first place, but there are countless people with brilliant ideas. What makes these individuals unique is their ability to turn those ideas into a real thing. For example, a Harvard sophomore would have never created an attractiveness-ranking website that would one day turn into a social network that changed the face of human interaction if he didn't have a background in coding. I am, of course, talking about Facebook creator Mark Zuckerberg.
This sentiment is echoed throughout the testimonials found in the Code.org video. Brilliant people like Bill Gates, Gabe Newell, Jack Dorsey, and Drew Houston all created their companies thanks to their ability to write code. They inspired others to work for their cause because they could show that their ideas worked in practice. Without the examples set by Gates, Jobs and Wozniak in the 1970s, who would have believed that the personal computer could do anything of worth by reading over an idea pitch? Not many, and yet look at how ubiquitous computing has become.
The team at Code.org is taking a similar "do instead of tell" approach by making their aim encouraging students to request coding classes. At the high school I attended in Greenwich, Connecticut, there were numerous special interest subjects being taught, but rarely was coding one of them. This is one of wealthiest towns in the country we're talking about. After talking with a high school friend of mine, he said the following: "I got [Greenwich High School] to do Intro to Computer Science one semester, but they cut it after that semester."
While it's easy to blame education officials for devaluing this subject, the real problem here is that students don't know why such a skill is valuable to them. The stereotype of a coder, at least when you're a teenager, is that of a overweight mega-nerd who lives in their parents' basement and has no friends. As such, even when a class in coding is made available to them, most students won't give it an iota of consideration. The first steps to forming a grassroots movement at the student level is to change their attitude towards the subject. Code.org knows this as shown by their inclusion of basketball player Chris Bosh and musician will.i.am among the testimonials of tech heroes.
I'm not a fan of will.i.am's music, and due to my lack of sports knowledge I didn't even know who Chris Bosh was until I looked him up, yet the perspective they had on this issue had a larger impact on me than everything else in the video. Bosh's story about how he ignored teasing from friends when he joined an after-school coding club, and will.i.am's quotable insight that "great coders are today's rock stars," really drive home the idea that what's cool are the things that make you smart. As Marshall McLuhan famously said, the medium is the message. The more pop culture figures (and, to this effect, women coders) who advocate the "coolness" of coding, the less taboo it will become.
Negative stereotyping isn't the only factor preventing students from taking to the computer alongside other hobbies and educational endeavors, though. Terminals full of endless lines of meaningless numbers, letters and symbols are damn intimidating. Even computer buffs can be turned off by this mental road block. My favorite quote from the video that busts this myth is from Bronwen Grimes, a technical artist at Valve, who says, "You don't have to be a genius to code. Do you have to be a genius to read?" By equating coding to an interaction with language, Grimes takes something that seems to foreign and makes it familiar.
Look at it this way: when you go to another country with a language you don't know, it's naturally overwhelming. However, as you spend time in that country, you quickly pick up on the sounds, words and phrases used by its inhabitants. Think of coding as a foreign country. It's a far less scary prospect than your initial instinct would have you think. I know this from personal experience.
When I was a junior in high school, I decided that I wanted to learn Objective-C to create my own iOS apps. Because no courses about coding were taught at my school, I ended up teaching myself. After an afternoon of following a free guide I found on the internet, I was able to create my own Fahrenheit-Celsius converter complete with a GUI (graphical user interface). This was my first foray into coding and I was already seeing results. One of my greatest regrets in life was not continuing down this path, but things could have been different had there been an educational outlet at my high school. I do hope to pick this hobby back up in my spare time, and this video only provided further encouragement.
Here's another plus to learning how to code: understanding the language of digital technology and its endless impact on our world straight-up makes us smarter people. This may seem trivial, but in an economy where jobs are scarce, knowing programming can make you a viable candidate for millions of open jobs according to Code.org. As Zuckerberg states, "[Facebook's] policy is literally to hire as many talented engineers as we can find. The whole limit in the system is that there just aren't enough people who are trained and have these skills today."
For any student looking to get a head-start on their future, this should be throwing up red flags all over the place. This skill set is in high demand but the number of people who have it are scarce. It begs students to ask the question as to whether it's more important to submit to peer pressure for the short-term or set themselves up for the long-term. We all know from experience that this foresight isn't innate in teenagers, making the need for carefully crafted messages and pop culture icons critical. For example, the office perks shown off in the video are quite enticing. And hey, is that Deadmau5? His music is made possible thanks to code.
There's another angle to the job issue that the video only touches on: you don't need to make a profession out of coding in order for the skill to be of use. I'll use myself as an example: I write about video games, which are nothing more than code at their core. My job would not exist without the video game industry, which in turn would not exist without coders.
As a critic, even understanding the difficulties of development at a base level gives me a deeper insight than another critic without this. Despite my job not directly requiring me to write code (beyond some basic HTML), I benefit from that afternoon I spent learning Objective-C immensely. Imagine what a full class on the subject could do for me or others like me. There's no two ways about it: whether you realize it or not, you could be better at your job with programming knowledge. Yes, that applies to you boss-types as well. Understanding what your employees do will both make your leadership more effective as well as garner mutual respect in the office.
In a Google Hangout two weeks ago, President Obama was asked about his stance on teaching programming in high schools. You can see his response in the following video:
I love Obama's angle on the subject. Selling the idea of coding as a gateway to making your own video games gives it relevance to high school students. However, like coders with ideas being able to demonstrate them, it will take focused efforts by both grassroots organizations like Code.org and the government to get the message out. Working with school districts is important, but if you don't convince students that they should care about coding in the first place what good does it do?
If you take one thing away from all this, let it be the importance of motivating students to learn code. Anybody can do this. Relay this message to teenagers in a way that they can relate to. Take it upon yourself to learn the basics of coding as an example. Even if you don't have the time to get directly involved, support those who do.
So much of what we learn in school teaches us how the world was. Perhaps it's time we started learning how the world is.


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Commissioner David Stern dropped the bomb on us yesterday. Games are going to be missed in the upcoming NBA season.
I know they only announced the cancellation of the first two weeks, but if you think this is not just the first of at least a couple cancellations, you're just kidding yourself. Either way it does not leave a good taste int he mouths of hoops fans everywhere.
With this announcement, let's take a look around the league and see who may be hit the most by an extended lockout and how it can effect the shape of the league going forward.
Here's a list of the top five teams that will be effected most by this stand off between players and owners. Let me know what you think.


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State and county officials reopened the beach area in Waihee Monday where a diver was bitten by a shark Sunday morning.
The beach had been closed from Round Table to the Paukukalo River Mouth since after 8 a.m. Sunday.
Maui County Ocean Safety and the Department of Land and Natural Resources evaluated the area and opened the beach at 11 a.m. Monday.


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Life is but a dream
With another fun-filled week under my belt, I'm ready to catch up with my cohorts at The River Reporter and get their take on the events that I missed, check out the pictures on our Facebook page and prepare for the onslaught of more summer fun coming up. Taking a moment to breathe, I find myself in the hammock (in the still of the night) and realize that those Doo Wop lyrics still hold true. For those of us fortunate to call this glorious landscape home, sometimes...life is but a dream.
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This job is posted at www[dot]IndiaTechJob[dot]com GSS Infotech requires IT professionals. Walk-in Interviews at Hyderabad. Positions: Cloud Architect NOC-Tech Lead – Linux / Windows / Virtulisation / ESM Tools Cloud Test Engineers Data Center Architect Service Desk Engineers Mail resume with Job Code to: email@example.com Or Walk-in Cyber Pearl, Block-2, Level-5, Wing 05-01, HITEC City, Madhapur, Hyderabad For details please click on the image below: This information is available at http://www.indiatechjob.com For Latest IT jobs in India please visit http://www.indiatechjob.com
[via IT, Engineering & Technical Jobs in India]
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and you'll receive a notification when new content is published
This fall we've rolled out several successful promotions that have helped our publishers earn additional revenue simply by doing what they do best. Today, that continues with the announcement of our U.S. Holiday promotion!
How does the promotion work?
If you increase your QCP earnings by at least 20% (compared to your earnings in June 2012) during November and December, ... Read more
As you may have seen, we were in London at the A4U Expo last week. There were lots of interesting issues being discussed and some fascinating knowledge being shared. Sessions ranged from tips on how to use social media to maximise your traffic, to the legalities of running a website. There was even insight into how weather affects sales – ... Read more
Treating yourself to increased earnings around Halloween doesn't require tricks, just a focus on some of the hottest items of the spooktacular season. We began noticing an increase in Halloween-related searches on eBay mid-September, and expect sales to peak just before the holiday hits on October 31st.
So what can you do to ensure your visitors are howling with delight? ... Read more
Now that we're squarely entrenched in the middle of October, it won't be long until Holiday season will be in full swing. For many that means festive family gatherings and the inevitable buzz around holiday shopping. Here at eBay Partner Network we're getting in the spirit by offering you the chance to earn a bonus from your European campaigns this ... Read more
The time has come again for one of the biggest UK events in performance marketing, the A4U Expo hosted in London.
Following last year's success, we will once again be at the conference and will be offering our support by being a sponsor.
The event, which is being held at The Hilton Metropole on 16-17 October, is a valuable ... Read more
In just a few short weeks, students will be loading up their backpacks and heading off to school. You can help parents prepare by highlighting learning and living essentials for students of all ages, from crayons for kindergarteners to computers for college kids. Sales of back-to-school items have begun to climb and peak during the first half of August, so ... Read more
Did you know that Link Generator is probably the most versatile and user-friendly tool available out of all of ePN's offerings? In addition to creating Text Links, it allows you to quickly pick up affiliate code to make anything trackable on your site (content, images, video), to any landing page on eBay. We frequently get questions from ePN Partners on ... Read more
Well, it's that time of year and once again – a4uexpo is upon us! This year it's being held in the wonderful city of Barcelona on the 19-20th of June and eBay Partner Network are proud to announce that our very own Christian Erhard, Head of Partner Management Europe, will be giving a presentation on "Valuing Partner Traffic through ... Read more
It's finally here! Euro 2012 starts in Poland and Ukraine today. On eBay, we can see fans have been getting excited about it as they prepare themselves for the upcoming matches and are ready to cheer on their favorite teams in the stadiums, at public viewing parties or in front of the TV. In anticipation to the build up for ... Read more
The first official month of summer also means it's time for family members to break out their party pants in celebration of proud dads and eager grads. School is out for the summer (or forever) as university and high school students toss their caps in the air throughout May and June. Dad goes from proud to pampered papa when he ... Read more


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Golf Course and Driving Range
Come join us for the Inaugural Sturgeon Point Classic July 9th and kick off the summer with a catered dinner, live band, live and silent auction items and awards for several categories.
"Welcome to our Golf Club."
Sturgeon Point Golf Club is a unique full service golf facility - with a fully licensed clubhouse, a full practice range, putting and chipping greens, with sandtraps - we have all the amenities of a private club, open to the public.
Our historic premier 9 hole golf club built in 1899 continues to build on the tradition of deceptively challenging but accessible golf.
The course takes you along Sturgeon Lake, playing alongside the lake and through mature oaks and pines, its layout lending itself to an easily walkable round.
With course conditions unparalleled in the region, this mature course will challenge good golfers, but stay accessible to those out for a good time.
With friendly staff waiting to welcome you and quick play the local rule, Sturgeon Point Golf Club is a course you will not want to miss when golfing in the Kawarthas. We look forward to welcoming you to our historic golf club.


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Kettering Central Dental Practice cares for their patient's entire dental health. The office team works with the patients to come up with a plan for dental care. All patient questions are answered prior to beginning any proceedure. Services include all bridges and veneers to cleaning. Gum treatment and teeth whitening is also available for patients.
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Orthodontic Services
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Dental Restorations
Public transport access
Private Patients Welcome
Dental Plans Accepted
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