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Pathfinder Battles—Deadly Foes: Pathfinder Society Leader
Pathfinder Battles—Deadly Foes: Invisible Guardian
Pathfinder Battles—Deadly Foes: Rope Trick
Wizard's Academy (PFRPG) PDF
Samurai of Porphyra (OGL) PDF
Pathfinder Society GM. 182 posts (183 including aliases). 3 reviews. No lists. No wishlists. 8 Pathfinder Society characters. 1 alias.
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I ran this scenario recently for PFS and I must admit I was disappointed by the result. While the story, ideas, and enemies are all creative and interesting, the scenario is messy and sometimes unclear on how to handle certain situations. Information is poorly-organized, and excessive stat blocks for unique and variant enemies make some sections hard to read.
If you plan on running this scenario, I would recommend a hefty amount of preparation beforehand. Make sure you understand NPC interactions in each room, and read-up on all the effects and how they work ahead of time so you don't have to look it up later.
Print Edition
Mythic Realms is the latest addition to the Pathfinder Campaign Setting, and promises some impressive ideas. Powerful figures from Golarion's lore, sites of incredible power, and even the legendary Starstone. But closer examination finds the book's contents lacking, its concepts deprived of the execution expected of a Paizo work.
Chapter I contains information on Founts of Mythic Power, like the Cenotaph, the Morudant Spire, and even the Starstone(!). Mythic Founts are sort of like "seeds" GMs can use to transform high-level groups from extraordinary to truly heroic. The idea is great--it provides GMs with high-level groups to continue the adventure even when all other challenges begin to feel trivial. Furthermore, there are unique mythic abilities tied to the mythic ascension that occurs at each location.
The problem here is that not all founts are created equal, and this is particularly true of the Starstone. First off, the mystique of the Starstone test is all but obliterated by the book's presentation, and second, the Starstone's role in the lore is inexplicably changed. Suddenly the Starstone is only a means of mythic ascension, not the engine of divine apotheosis we've been lead to believe. What's worse is that the mythic ascension triggered by the Starstone provides bonuses linked to pre-existing gods, and only the twenty greater powers of the Inner Sea (so no blessing of Apsu, Tiamat, Shizuru, Tsukiyo, &c).
Furthermore, Mythic Realms paints a very confusing picture of Golarion's history. Did the Aboleth fear Azlant, or did they grow bored with their human experiment? The historical accounts in the Morudant Spire seem to conflict with those in the Starstone, but this isn't the only contradiction. The history of the war between Azlanist and Karzoug grows more confusing. Who was winning? Who was planning to summon the Oliphaunt of Janderlay?
Chapter II is, in my opinion, the best part of this book. It contains Gazetteers on six locations for your mythic heroes to explore. Although, again, historical accounts sometimes contradict themselves (I now have two conflicting accounts of what happened to the city of Gormuz). Still, the imaginative settings give GMs a lot to work with when planning their own adventures, and one entry can provide dozens of potential ideas for any given mythic campaign.
If Chapter I is my least favorite and Chapter II my most, then Chapter III falls somewhere in the middle. Here we find a bestiary of several legendary figures throughout Golarion's lore, from the terrifying to the heroic. This is both a good and a bad thing, in my opinion, as it provides mythic groups with epic challenges, but at the same time somewhat demystifies these otherwise mythical characters.
There is an adage once uttered on "The Spoony Experiment," which goes "if you can stat it, they can kill it." Simply put, this suggests that if you give a creature concrete representation in the rules system, then it becomes subject to the whims of that system, including death. Now, there are always ways to get around this (AD&D Fiend Folio's Trillioch, anyone?) but caveats that prevent defeat kind of feel cheap when you have a fat block of numbers and words staring you in the face.
That said, the histories of each mythic character are fantastic, if not unfortunately brief in some places. They manage to retain the intangible nature of the myths and representations these characters enjoyed in previous source material, never willing to commit too much detail where detail isn't needed, which in my mind is only ever a good thing.
All-in-all, the book had some great ideas and inspires some great ideas. The problem comes with the mechanical execution of those ideas, and the inconsistencies generated by its new treatments of setting-specific features. It's a 2-out-of-5, worth having for the ideas, but not the rules.
There's a lot to say about this book, some of it good, some of it bad. For the most part, I can say that it is a fun book with a lot of interesting archetypes and character ideas, along with a few good feats, cool spells, and thoughtful mechanics. Of course, the exact same points could be made against the book: useless archetypes, pointless feats, silly spells, and bad mechanics.
Ultimate Magic suffers the same problem a lot of supplemental material in 3.5 did, in which the book does not feel as tight design-wise as it otherwise could be, given the incredibly limited application of some of it's contents. Consider the Witch hex "child scent," for example: When are you ever going to need to sniff out children? This feels like a villain-only ability, and even then you could probably give your villain witch a more useful hex. The same goes for the construct modifications. They're neat, but they're not worth it to most spell casters, better used for a dramatic villain fight than an actual player. Or maybe "cartoony" would be a more appropriate description- there's something strikingly reminiscent of Power Rangers that involves the bad guy combining with his robot helper. Also: The geisha Bard archetype. What the heck, man. Tea ceremony, really? It's neat and flavorful, but it breaks flow and forces me as both a player and a GM into that uncanny valley of "yes, I suppose you guys do technically have 10 minutes outside the boss room." I mean, it's not like the dragon's going to eat the princess any time soon, or anything...
Of course, for all the bad ideas there are good ones too. The magus looks like a fun class, albeit he loses out on damage output against classes such as the barbarian or the rogue, but he makes up for it with the versatility of spellcasting (and I absolutely adore the staff magus archetype). I also really like the customization of the Qinggong monk, and think the alternative channeling powers are amazing. However, these traits alone to not make the book great, only good.
Also, this is a nit-pick, but Paizo didn't fix the typo in the vivisectionist archetype for the alchemist. This typo was pointed out when they previewed the archetype, the editors responded to the post, and the mistake still made it into the final printing. Vivisectionists can't benefit from plague bomb because they don't *get* bombs. You think that a company as good as Paizo wouldn't let a mistake like that slip past them after it was brought to their attention.
In conclusion, Ultimate Magic is one of those books which is handy to have around for the additional options, but is by no means a "must buy."
©2002–2016 Paizo Inc.®. Need help? Email firstname.lastname@example.com or call 425-250-0800 during our business hours: Monday–Friday, 10 AM–5 PM Pacific Time. View our privacy policy. Paizo Inc., Paizo, the Paizo golem logo, Pathfinder, the Pathfinder logo, Pathfinder Society, GameMastery, and Planet Stories are registered trademarks of Paizo Inc., and Pathfinder Roleplaying Game, Pathfinder Campaign Setting, Pathfinder Adventure Path, Pathfinder Adventure Card Game, Pathfinder Player Companion, Pathfinder Modules, Pathfinder Tales, Pathfinder Battles, Pathfinder Online, PaizoCon, RPG Superstar, The Golem's Got It, Titanic Games, the Titanic logo, and the Planet Stories planet logo are trademarks of Paizo Inc. Dungeons & Dragons, Dragon, Dungeon, and Polyhedron are registered trademarks of Wizards of the Coast, Inc., a subsidiary of Hasbro, Inc., and have been used by Paizo Inc. under license. Most product names are trademarks owned or used under license by the companies that publish those products; use of such names without mention of trademark status should not be construed as a challenge to such status.


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Gene Therapy in Treating Women With Metastatic Breast Cancer
Recruitment status was: Recruiting
- Full Text View
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- Disclaimer
- How to Read a Study Record
RATIONALE: Placing the gene for interleukin-12 into breast cancer cells may help the body build an immune response to kill tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of gene therapy in treating women with metastatic breast cancer.
Breast Cancer
Biological: adenovirus-mediated human interleukin-12
Other: enzyme-linked immunosorbent assay
Other: fluorescence activated cell sorting
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis
Phase 1
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Phase I Trial of Adenoviral Vector Delivery of the Human Interleukin-12 cDNA by Intratumoral Injection in Patents With Metastatic Breast Cancer
- Maximum tolerated dose [ Designated as safety issue: Yes ]
- Toxicity and safety as assessed by NCI CTCAE v3.0 [ Designated as safety issue: Yes ]
- Tumor response (complete response, partial response, stable disease, or disease progression) [ Designated as safety issue: No ]
- Immune response [ Designated as safety issue: No ]
|Estimated Enrollment:
|Study Start Date:
|August 2008
|Estimated Primary Completion Date:
|August 2010 (Final data collection date for primary outcome measure)
- Determine the toxicity and maximum tolerated dose of intratumoral injection of adenovirus-mediated human interleukin-12 gene in women with metastatic breast cancer.
- Determine the tumor response in patients treated with this regimen.
- Determine the immune response in patients treated with this regimen.
OUTLINE: Patients receive a single dose of adenovirus-mediated human interleukin-12 intratumorally via percutaneous needle placement under ultrasound guidance.
Blood and tumor tissue samples are collected periodically for immunological laboratory studies. Samples are analyzed for serum cytokine levels by ELISA; qualitative analysis of immune biomarkers by IHC staining; and immune cell biomarker analysis by FACS.
After completion of study therapy, patients are followed periodically.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Histologically or cytologically confirmed metastatic adenocarcinoma of the breast
Malignant disease in the skin, chest wall, or other sites (lymph nodes or primary tumor in the breast) accessible to percutaneous needle placement and injection
- Solitary or multiple tumors
- Measurable disease in ≥ 2 dimensions by physical examination or CT/MRI scan
- Malignant tumors in the skin and chest wall must be ≥ 4 mm in diameter by physical examination
- Malignant tumors in other accessible sites must be ≥ 1 cm in diameter on physical examination
- Malignant disease in other organs (in addition to skin or chest wall metastases) allowed
- Hormone receptor status not specified
- Menopausal status not specified
- Karnofsky performance status 70-100%
- Life expectancy ≥ 16 weeks
- Granulocyte count ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- Hemoglobin ≥ 9.0 mg/dL
- PT normal
- Serum creatinine ≤ 1.5 mg/dL OR creatinine clearance ≥ 45 mL/min
- Serum total bilirubin ≤ 2.0 times upper limit of normal (ULN)
- Serum transaminases ≤ 2.5 times ULN
- Not pregnant or nursing
- Negative pregnancy test
- Weight ≥ 30 kg (for patients treated with the highest dose level of study drug)
- No active infection or concurrent serious medical illness
- No HIV positivity
No other malignancy within the past 5 years except for the following:
- Inactive nonmelanoma skin cancer
- In situ carcinoma of the cervix
- Grade 1 papillary bladder cancer
- More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas)
- No anticoagulant therapy with heparin or warfarin for ≥ 2 months after completion of study treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00849459
|United States, New York
|Mount Sinai School of Medicine
|New York, New York, United States, 10029
|Principal Investigator:
|Max W. Sung, MD
|Icahn School of Medicine at Mount Sinai
|Responsible Party:
|Max W. Sung, Mount Sinai Medical Center
|ClinicalTrials.gov Identifier:
|NCT00849459 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 20, 2009
|Last Updated:
|June 9, 2009
|Health Authority:
Keywords provided by National Cancer Institute (NCI):
recurrent breast cancer
stage IV breast cancer
Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Adjuvants, Immunologic
Immunologic Factors
Physiological Effects of Drugs
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Growth Inhibitors
Antineoplastic Agents
ClinicalTrials.gov processed this record on December 05, 2016

subset: commoncrawl


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Die Antwoord 'Kills' Lady Gaga Lookalike In Music Video; She Strikes Back
South African rap group Die Antwoord kills a Lady Gaga lookalike in its latest music video, and it isn't making the "Poker Face" singer very happy.
In the video "Fatty Boom Boom," a man dressed in Gaga's infamous meat dress is ridiculed and massacred by African rebels and mauled to death by a lion.
In another scene a gynecologist removes a shrimp from the fake Gaga's genitals, presumably a joke about past stories suggesting the singer is a hermaphrodite.
In response to the video, Gaga posted on Twitter, "i fink u freaky but you don't have a hit. hundred thousand tickets sold in SA. #thatsmys**t... i guess its not a good idea to tell someone you're a fan. never mind! we get it, you're not a little monster (fan)".
Die Antwoord responded, "lady... even tho (though) u r 'larger' than us... we still cooler than u... plus we don't have prawns in our private...(sic)".
The group, led by rappers Ninja and Yo-Landi Vi$$er, revealed over the summer that Gaga approached them to tour with her, but they opted not to.
Watch the "Fatty Boom Boom" video (WARNING: Explicit Language):


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With March Madness right around the corner, every NBA scout is getting their pen and paper ready. Scouts will be watching closely during the madness in hope of finding the next stars.
March Madness is something else. For three weeks eyes are glued to televisions across the country.
In a time long ago, the NCAA tournament was the breeding ground for the NBA's next big stars.
However, it isn't the same anymore. With the new one-and-done rule, all the exciting players leave after just one year of college.
Unfortunately, this is a year of parity among mediocre teams and players, leaving us with only a few top prospects to watch during the madness.
For the sake of this list, I will rate the top 10 prospects to watch for, along with a honorable mention list.


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Kid Nature Sawyer Corduroy Shorts
Same great fit as our Forest Cord Jeans, but in shorts! These slim fit cord shorts for boys have front and back pockets and belt loops. There is elastic in the waistband for a comfy fit which can be adjusted with an internal button. Designed to sit below the knee to protect little knees. Made from 100% organic cotton corduroy.
This style is also available in our Nature Baby sizes for 2 year olds.
product details
product code: KN11745
- 100% pure certified organic cotton corduroy
- front and back pockets
- belt loops
- folded hemline
- elastic waistband with internal button for easy adjustment
- length sits just below the knee
- 100% pure certified organic cotton corduroy
machine wash in cold or warm water with environmentally friendly laundry detergent
tumble dry on low or line dry
do not use fabric softner or bleach
see here for laundry tips
delivery and returns
Free shipping on all orders over $150 (excludes oversized items)
For more information about our flat rates and delivery, please see our delivery page.
You are welcome to return online purchases within 30 days, click here to view the full Returns Policy.
why choose organic cotton?
Organic cotton is fine, soft and strong. It is the ideal fabric for a baby's sensitive skin as it is grown and processed without the use of harmful chemicals. Conventionally grown cotton is one of the most destructive crops grown in the world today, whereas organic cotton farming promotes clean air, water and soil. Organic Cotton does not endanger wildlife or human health. So you can rest assured you are getting the most pure product, ensuring a healthy start for your baby.read more


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Submit Content
Sensor-Operated Flush Valve
Moen Inc. announced the release of the FreeHand sensor-operated flush valve. The valve provides energy savings by using an infrared sensor to activate the flush cycle, which ensures efficient water use, according to the company. The sensor uses standard AA batteries or an AC adapter. Features include a 24-hour sentinel flush, self-cleaning filter system, operating pressures ranging from 10 to 120 PSI, manual override button and self-lubricating silicone seals.
Low-Flow Urinals
Sloan Valve Company introduces a series of high-efficiency vitreous china urinals that utilize one pint of water to flush, which contribute to LEED credits 3.1 and 3.2 for water reduction.
Toilet/Sink COMBO
Willoughby Industries offers the combination lavatory/sink unit fabricated from 14-gauge, type 304 stainless steel. The fixture is designed for installation on a finished wall and serviced from an accessible pipe chase. Features include a 13-inch x 9.5-inch x 6-inch elongated toilet bowl, a contoured seat with flushing rim, fast drain with air vent, a 1.5-inch lavatory elbow waste, stainless steel penal filler/bubbler, air-circulating, self-draining soap dish and mounting hardware. Optional features include lavatory valves and waste connections, fixture mounted accessories, toilet overflow preventer, wall sleeves and templates, low-flow 1.6 GPF toilet, flush valves and connections, and toilet waste connections.
Facility Water Control
Sloan Valve Company offers several models of its Royal Flushometers for prisons. The products are built to withstand high-use and high-abuse environments while offering water-saving flush cycles to conserve water and reduce operating expenses. The units are concealed and the diaphragm-type Flushometers are available for water closets and urinals. The new Hydraulic Royal Model 9611 for water closets has two non-hold-open actuator types — a metal button fixture-wall or a panel-mount actuator. It also features high-copper/low-zinc brass casting for dezincification resistance, fixed metering bypass, and no external volume adjustment to ensure water conservation. The company also offers its Programmed Water Technologies product line, which includes systems that allow remote or centralized control of toilets, sinks and showers. The product line allows facility operators to control usage to individual fixtures or entire building for maintenance and security reasons.
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Spacious Room in Central Location (5)
Size18 m²
Floor No.
- Kitchen
- Washer/dryer
- Lockable room
- Towels
- Internet/WiFi
Accommodation summary
|Widegate St, E1 7HP London, United Kingdom
|Property type
|Private room
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
You'll find a plasma TV, freezer and internet access. We have all bed linen, changed every week. You can access a shared fitted kitchen with washing machine. Bathroom has soap and shampoo for your comfort. Everything you need for a perfect stay in London.
Close both to the high- octane world of the City of London and also near to London's trendy east End, with Shoreditch and Brick Lane very nearby. Liverpool Street Tube Station is just 1 minute walk away. Liverpool Street is a big transport hub with connections all over the great city of London.
Shoreditch is in the east of central London and is one of the most popular areas in London at the moment. It is full of trendy cafés, bars, restaurants and other meeting points such as galleries and small shops. There are also a lot of exciting markets surrounding the area such as Brick Lane Market, Broadway Market and Colombia Road Market.
A short walk away from Shoreditch is Liverpool Street station where you can access Central Line, which will take you to the Oxford Street in 10 minutes. Oxford Street is the main shopping street in London, and nearby are a lot of the typical attractions of London. There are also plenty of buses and night buses running 24/7 from all directions in London.
Whether you want to enjoy a day (or night) out in central London, or chill out with the locals in one of the markets, Shoreditch is the perfect location for you. Enjoy an amazing stay in London.
House rules
|Price for > 1 guests
|$ 9 US per guest/night extra
|Check-in after
|Check-in before
|Check-out before
|Cancellation Policy
Reviews for this host's other properties
I booked one of these apartments next to London Liverpool Street.
Bathroom was moldy, kichen was dirty too. Marcos told me after booking, rooms were cleaned every day. During my stay, room was not obviously cleaned at all . Room was very small, description told me 20 square meters. I have never been to London before, okay, one could have guessed probably that big rooms might be hard to get. But I would have chosen other opportunities if I had knew it before. Hostel for example for less money or some apartments for the same price but more confortable, even though they would have been farer away. I think he should change room description and take a bit more care of his apartments.
The apartment is very central, just in front of Liverpool Street station.
The place is nice but, unfortunately, not very tidy.
Everything ok - THANK YOU!
Although Mark is very nice, the room and is beautiful, and it's in Shoreditch and is a nice apartment. The proof is that my wife has been riddled with bug bites. I wish I could post pictures. The room is small, the cupboard falls apart (and has bed bugs!) And you can pull the door five minutes to open it. The bathroom is a mess, broken and small and uncomfortable and full of mosquitoes. It is on the ground floor of a building working class, though not dangerous, has no charm.
We went to a hotel a day before completing the booking and we were not before not find accommodation. With that I think that says it all.
A pesar de que Marcos es muy agradable, la habitación ni es preciosa, ni está en Shoreditch ni es un agradable apartamento. La prueba es que mi mujer se ha quedado plagada de picaduras de chinches. Me gustaría poder poner las fotos. La habitación es pequeña, el armario se cae en pedazos (¡y tiene chinches la cama!) y la puerta te puedes tirar cinco minutos para abrirla. El baño es un asco, roto y pequeño e incómodo y lleno de mosquitos. Está en el bajo de un edificio de clase trabajadora que, aunque no es peligroso, no tiene ningún encanto.
Nos fuimos a un hotel un día antes de terminar la reserva y no nos fuimos antes por no encontrar alojamiento. Con eso creo que se dice todo.
Very good place to stay if you need to catch a train to Stansted Airport from Liverpool Station. It took me about three minutes to walk there. The room was small but clean, bathroom and kitchen were shared with others but also very clean. I was welcomed very friendly at the reception and enjoyed my stay.
Clean and well equipped. The flat was close to bus stop and tube station. Located in a loud area, but that didnt disturb me. Also very close to grocery stores and restaurants. Marcos was friendly and made me feel very welcome!
The receptionist was very friendly but the room was so small that the bed took almost all of the room. Very thin walls. But everything was clean and the location is top! Still it is London we're talking about, so for this price-range pretty much everything is acceptable
The bedroom is like the pictures. They were very kind and helpfull.
2nd Floor by stairs.
The only issue, was that there were people a bit noisy and the walls are very thin, so you hear everything like if it were inside the room, some mornings the noise waked up us.
Clean & comfortable accommodation. Central location.
A fast, simple and easy reservation.
I stayed one night, slept well, and I was welcomed very well by Marcos.
I will attempt to be as fair as possible:
The pros: it is simply near the Tube station, well maintained and cleaned
The con: some improvement could be made in the bathroom, but indeed it is clean
Well, on the overall, it was a useful and positive experience.
- Quality assured accommodation
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Wednesday nights are the most fun night of the week! If you are a high school student or new to our church, you have got to come experience Wednesday night worship at Catalyst!
Our Sunday morning experience is designed to take students deeper into the Bible with the intent of exposing them to how the gospel is applicable to their everyday lives.
Stay up-to-date with all of our upcoming events! You can also download the Catalyst App in the App Store or register to receive Text Message updates to stay in the loop!


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Journal of Markets & Morality
Purchase a subscription to the Journal of Markets & Morality to get access to the most recent issues.
Learn more at MarketsAndMorality.com | Subscribe
The Pontifical Lateran University was the scene this Thursday of a day-long conference on Ethics, Aging, and the Coming Healthcare Challenge, which looked at ethical, medical, and economic issues arising in light of the new challenges presented by aging demographics and ever-extending life-spans.
Organized by the Acton Institute for the Study of Religion and Liberty, with the co-sponsorship of the Pontifical Council for the Family, and Human Life International, the conference brought together academics, practitioners, clergy, and policy-makers from around the world, to examine how subjects such as intellectual property rights, pharmaceutical research, healthcare infrastructure, and welfare reform may impact healthcare for the elderly and shape the character of intergenerational solidarity.
The secretary of the Pontifical Council for the Family, Bishop Jean Lafitte told Vatican Radio that the conference's focus is on the demographic crisis that looms over countries in Europe, especially. "One of [the factors contributing to the crisis] is a positive one," said Bishop Lafitte, "we have a hope of life, which is longer." By the same token, he continued, "the larger number of people getting old will have to be cared for by a smaller number of people in their active professional life."
Bishop Lafitte, who was also one of the contributors to the conference, told us his remarks tried to place the challenge of aging in a broader cultural context. "We are seeing in our societies, that people are getting older and older, and people are not ready anymore to welcome life as the good news." Also, he said, "There is no penetration between generations [by] which can develop feelings and action of solidarity."
Other co-sponsors of the daylong conference were the Centro di Orientamento Politico, Pontificio Istituto Giovanni Paolo II per Studi su Matrimonio e Famiglia, and the Associazione Famiglia Domani.


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Technical Specifications and Recommended Pricing
Today we are going to talk about a new mass production liquid-cooling system from Thermaltake and compare its efficiency against one of the super-coolers. Find out from our new review, which one proves more efficient.
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My MLK Day of Service Story
Blog Categories:
United We Serve
Iris Dooling is serving as the Eli Segal Fellow at the Corporation for National and Community Service. She formerly worked with Habitat for Humanity International as a Program Specialist for their AmeriCorps program in post-Katrina Louisiana. Today she is going to share with us her MLK Day of Service story.
If you are like me, you made New Year's resolutions this year that were fairly similar to the ones you made last year. Each year in late December, I resolve to "turn over a new leaf" and make better use of my spare time. Some of the items that reappear most frequently on my list are: volunteer more, learn more about my community, connect with my neighbors, and do something that benefits others. Although these resolutions seem simple enough, I often need a little push to translate them into reality. Instead of taking the initiative, I make excuses that "I don't have enough time; I don't know where to volunteer; I don't know what opportunities are out there."
Fortunately for me, and those with similar good intentions, Martin Luther King, Jr. Day of Service provides that little push I need to translate these resolutions into reality in 2010. In fact, volunteering on the Martin Luther King, Jr. Day of Service is so easy that there really is no excuse not to do it. Not only do we have the day off from work, but there is a convenient list of projects and locations at serve.gov/MLKDay. All I have to do is sign up, which is really easy.
The last time I volunteered for Martin Luther King, Jr. Day of Service, I was living in New Orleans and I really enjoyed my service. I was able to volunteer with my colleagues and other community members on a great project. Our group was composed of about 100 AmeriCorps members, middle school students, and faith-based community partners. We all met together at the beginning of the day for a presentation about Dr. King's life and mission and how it connected to the service that we were about to do. We then split into 3 groups based on our interests and skills. One group painted a mural at a local school, another group learned about green building from a local non-profit, and my group headed to the kitchen to prepare a huge spaghetti dinner for New Orleans' many homeless people. That day, I was able to connect with many inspirational people that I wouldn't have otherwise met. I was able to learn more about my community, my neighbors, and help out people in need. As my team and I worked together in the kitchen, we shared stories, laughs, and really bonded while we prepared a hot meal for those in need. That day of service really provided an opportunity for me to translate my good intentions into reality.
During his life, Martin Luther King, Jr. said that "everybody can be great because everybody can serve." Each person has something, no matter how small, that she can do to help others, but sometimes you just need a little push, a little extra incentive, to get started. This year, take advantage of the opportunity that Martin Luther King, Jr. provides. Go to serve.gov/MLKDay and check out the opportunities to serve. Make Martin Luther King, Jr. Day a day ON, not just a day off from work and get started on those resolutions while you are at it!
You can share your MLK Day story of service by visiting serve.gov/share.


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Inui, Ayano*; Fujisawa, Tomoo*; Kubo, Tomohiro†; Sogo, Tsuyoshi*; Komatsu, Haruki†; Kagata, Yutaka‡
*Department of Pediatrics, International University of Health and Welfare, Atami Hospital; †Department of Pediatrics, National Defense Medical College; ‡2nd Department of Pathology, National Defense Medical College
Address correspondence and reprint requests to Dr. Inui, Department of Pediatrics, International University of Health and Welfare, Atami Hospital, 13-1, Higashikaigan-cho, Atami, Shizuoka, 413-0012, Japan.
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Neonatal hemochromatosis (NH) is a rare disease defined by the coexistence of liver disease of antenatal onset with excess iron at extrahepatic sites. NH is not considered a single disorder but rather a syndrome of unknown etiology (1). We report a patient with histologically confirmed NH who survived the initial phase of liver failure, even though the level of lentil lectin A-reactive alpha-fetoprotein-L3 (AFP-L3) was high.
The patient is the second child of non-consanguineous Japanese parents. Routine antenatal screening tests were normal. His 5-year-old sister and his parents are healthy. Many relatives of his parents had histories of various kinds of cancer. The boy was delivered by urgent cesarean section under suspicion of acute placental hemorrhage at 38 weeks gestation. Apgar scores were 9/10/10 at 1, 5 and 10 minutes, respectively. Birth weight was 2894 g, height was 46 cm and head circumference was 33 cm.
At age 7 days, coagulopathy and hepatomegaly developed. The patient was admitted to the intensive care nursery, the trachea was intubated and ventilatory support given. The subsequent course of his disease was characterized by worsening hepatic function, thrombocytopenia and disseminated intravascular coagulation. Serum concentration of ferritin was very high (145,900 ng/mL; upper limit of normal, 250 ng/mL) before transfusion. Fresh-frozen plasma, vitamin K and packed red blood cells (120 mL) were administered without improvement of hepatic function. At age 28 days, T1-weighted magnetic resonance imaging revealed that the liver produced a signal similar to that of the spleen. T2-weighted magnetic resonance imaging at about the same level showed an abnormally low hepatic signal consistent with siderosis (Fig. 1).
At age 54 days, he was referred to our hospital with hepatic failure of unknown etiology. The physical examination revealed malnutrition (body weight: 1st centile; height: 3rd centile), jaundice, anemia and hepatomegaly.
The laboratory evaluations showed elevated alanine aminotransferase of 232 IU/L (normal upper limit, 35 IU/L), aspartate aminotransferase 464 IU/L (normal upper limit, 30 IU/L), prothrombin time activity of 41% (normal >80%), hepaplastin test of 30% (normal >70%), total/direct bilirubin of 8.6/6.2 mg/dL, and albumin of 2.9 g/dL. Serologic titers for hepatotropic viruses including hepatitis A, hepatitis B, hepatitis C, GB virus C, and TT virus, group of herpes viruses, adenovirus and enterovirus were all negative. No pathologic bacteria were cultured from blood, or body secretions. Urine and serum amino acid concentrations showed a pattern compatible with severe hepatic failure. No succinyl acetone was detected in urine. Urine bile acid concentrations showed a pattern compatible with cholestasis. Alpha 1 anti-trypsin concentration was normal. Serum AFP concentration and ratio of AFP-L3 were elevated at 205,600 ng/mL (normal upper limit, 1,000 ng/mL) and 21% (normal upper limit, 10%), respectively.
A plain computed tomographic abdominal scan showed increased density of the liver. Ultrasound findings showed high echogenicity of the liver. We assumed that his condition was compatible with NH. Serum measures of iron status at the age of 62 days showed elevated ferritin concentration (1,169.6 ng/mL), normal serum iron (175 μg/dL, normal range 40-180 μg/dL), low transferrin concentration (124 mg/dL, normal range 190-320 mg/dL) and markedly elevated transferrin (97.2%, upper normal limit 30%).
The histologic findings on needle liver biopsy at age 63 days showed fibrous septa surrounded by irregular islands of liver parenchyma (Fig. 2). Periportal hepatocytes contained extensive iron deposition, whereas there was no excess of iron in Kupffer cells (Fig. 3). The grading for iron content, performed using the method of Blisard et al (2), was +1.
Because the parents refused further treatment such as an antioxidant and chelator regimen or liver transplantation, the child's treatment consisted of transfusions of fresh-frozen plasma, supplementation with fat-soluble vitamins and a protein-reduced diet. At the age of 6 months, total bilirubin, alanine aminotransferase and hepaplastin test were all normal. At the age of 9 months, AFP was normal without detectable AFP-L3. At age 2 years he continued asymptomatic.
There have been several reports of NH occurring in siblings and half-siblings. A responsible gene has not yet been found in these families. The prognosis of NH is variable. Many infants die of hepatic failure or require liver transplantation, whereas some patients survive without any specific medication. Because NH is rare, it is important to observe the clinical course in detail in each case. Accumulated data will contribute to elucidation of the etiology of and guidelines for treatment. Recognition of this entity in living neonates like the patient in our case is necessary for a better understanding of etiology, pathogenesis and treatment. This is the fourth patient worldwide and the first patient in Japan to survive in good health (3-5).
This article reports a case of NH in which the patient survived without use of any specific medication such as an antioxidant and chelator regimen or liver transplantation and compares its clinical and pathologic features with those of two additional cases with favorable outcome (3,4). In our patient, serum ferritin level at the onset was extremely high (145,900 ng/mL). Serum alpha-fetoprotein was also very high (205,600 ng/mL), as was AFP-L3, a high level of which indicates high specificity of hepatocellular carcinoma in adults. At first, we supposed that the prognosis of this patient would be poor, and we informed his parents that his clinical course appeared to be fatal. His parents refused further medical therapy such as an antioxidant-chelation cocktail or liver transplantation because those measures were not curative. Contrary to our prediction, his clinical course was good. His development has been normal without medication.
Colletti and Clemmons (3) and Müller-Berghaus et al (4) previously reported cases with favorable outcomes. We compared the clinicopathogenic features of our patient with these other survivors (Table 1). Little difference was observed between the clinical features of our patient and the previous two patients. The serum ferritin level at onset was much higher in our case than in those of the other two survivors. Flynn et al. (6) reported that survivors receiving antioxidants had lower peak ferritin levels and a milder clinical phenotype. Serum ferritin level does not seem to have been one of the prognostic factors in our patient.
Proven or suspected infectious liver disease has been associated with a hemochromatotic phenotype (7-9). As Müller-Berghaus et al. (4) have reported, NH in some infants who survive might not be associated with metabolic disorder but rather with a single episode of submassive hepatocellular necrosis such that they are responsive to supportive care. Given that the liver is the primary site of apotransferrin synthesis, hepatocellular injury in utero may produce hypotransferrinemia (10). On the other hand, primary hypotransferrinemia is not associated with neonatal liver disease (11).
The grading for iron content in our patient was +1, a grade not associated with organ dysfunction in previous reports (2). Our patient had reduced signal intensity in the liver, suggesting siderosis, but evidence of pancreatic or myocardial siderosis was not demonstrated by magnetic resonance imaging. Oliveira et al. (12) reported a patient whose diagnosis, in the absence of iron deposits in salivary glands, was determined by abnormal ferritin levels and hepatic insufficiency and was confirmed by postmortem microscopic studies. In our case, because the specimens were obtained by needle biopsy, it is possible that insufficient liver was obtained for diagnosis.
Müller-Berghaus et al. also (4) reported that since NH is associated with a substantial risk for hepatocellular carcinoma, regular screening of α-fetoprotein is advisable. In fact, a case described by Oliveira et al. (12) revealed tumor nodule. Our patient had extremely high levels of α-fetoprotein in addition to a high ratio of L3. His condition, however, was very good. In an adult series with hepatocellular carcinoma, with the conventional cut-off level of 15% of α-fetoprotein-L3, α-fetoprotein-L3-positive hepatocellular carcinoma showed biologically malignant characteristics, especially portal vein invasion and lower tumor classification (13). In a pediatric series with hepatoblastoma, the level of α-fetoprotein-L3 was shown to decrease with the age of the patient at presentation, and did not correlate with prognosis of hepatoblastoma (14).
Siafakas et al. (15) reported that patients with abnormal bile acid metabolism may be a distinct subset of neonatal hemochromatosis with an accelerated course, no response to therapy and poor prognosis. The bile acid profile of our patient showed only cholestasis, which might partly explain his good condition.
In summary, our patient with NH-like liver failure might have had a single episode of submassive liver cell necrosis and regeneration from the perinatal to the neonatal period, which enabled him to survive without any specific medication for NH. The etiologic factors for this condition are still uncertain.
The authors are grateful to Dr. Makoto Obata, who referred the patient to us. We are grateful for the agreement with our case report of the patient's parents.
This article has been cited 1 time(s).
fetoprotein; lectin-reactive profiles; survival; outcome
© 2005 Lippincott Williams & Wilkins, Inc.
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January/February 2009
One Thought
Despite slight similarities, don't misconstrue this lineup of alto and tenor sax with rhythm section as some sort reworking of the Lennie Tristano Quintet ethos. Altoist Loren Stillman and tenorist Andrew Rathbun aren't Lee Konitz and Warne Marsh. And, of course, pianist George Colligan isn't Lennie.
Leader and bassist Scott Lee offers simple yet thought-provoking music on the aptly titled One Thought. It's not the sculpted sound of Tristano's best-known group, although it has some of its introverted intensity. Those who feel that jazz is losing its creative edge should hear this album and other basically mainstream offerings of the last few years.
The rhythm team of Colligan, Lee and drummer Jeff Hirshfield allows the frontline players the latitude to glide within these loosely woven musical frameworks, all crafted by Lee, a fine player both arco and pizzicato. The music is largely quiet and contemplative, yet also often shifts into freer zones of communication. The point is that it's more about deep listening than toe-tapping and head-bobbing.
Although there are some driving solo moments on the opening track, "A.R.," it's somewhat past the halfway point in the album before the music gets into a conventional swinging feel with the seventh track, "The Lope," followed by "Form and a Twist," which is in a similar vein. "Switch" is a controlled free conversation between the two horns. The penultimate "Conversations" reverts to the quiet zone before the album closes with the bright but open "P.S. 11."


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Big Thompson to Flatiron 13.8 Kilovolt Transmission Line Structure Replacement
CX(s) Applied: B1.3
Date: 05/09/2012
Location(s): Colorado
Offices(s): Western Area Power Administration-Rocky Mountain Region
Western Area Power Administration (Western) proposes to replace four existing single wood pole structures along the Big Thompson to Flatiron 13.8 kilovolt (kV) transmission line. The structures are located along a previously disturbed area adjacent to the Horsetooth Supply Canal in Larimer County, Colorado. The structures will be replaced in-kind with single wood poles of the same height, hardware, configuration, and in the same location.


text:
The $20 billion computer and video gaming business is the fastest-growing entertainment medium in the world---on track to surpass both the movie and record businesses. More than 200 million computer and video games are sold to the 140 million gamers in America every year.
Game Plan: The Insiders Guide to Breaking In and Succeeding in the Computer and Video Game Business is the first book that clearly explains how to get a foot in the door to this incredibly dynamic… (more)
Publisher: St. Martin's Press (April 01, 2007)
Collection: St. Martin's Griffin
Format: EPUB
Protection: DRM
Language: English


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3 injured in Westminster hit-and-run
WESTMINSTER – Three women were injured Friday morning in a hit-and-run while crossing the street, according to police, who are searching for the driver.
Hung Than, 66; Sa Than, 74; and Mai Nguyen, 70, were crossing Olive Street near Westminster Boulevard around 7:15 a.m. when the driver of a gray four-door Hyundai hit them in the crosswalk, police said.
"The driver had to know they hit three people, but didn't try to stop and help them," said Sgt. Richard Mize.
All three were taken to UCI Medical Center in Orange and are expected to survive, police said.
Mize said several witnesses recounted the story to officers, but the accident is being investigated.
Police are asking anyone with information to contact the Westminster Police Traffic Division at 714-898-3315.
Correction: Because of incorrect information provided by a source the genders of the people hit were incorrect in an earlier version of this story.
Contact the writer: (714) 704-3764 or email@example.com
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Gates, Mathews Listed as QuestionableThe San Diego Chargers won't have running back Ryan Mathews or tight end Antonio Gates. But Gates is listed as inactive. Gates had only played football during his sophomore year of high school and "I didn't like it." That summer, Gates worked out with Sco… (more)Source: chargers.com
Antonio Gates inactive for ChargersSAN DIEGO -- Another game, another lost weapon for quarterback Philip Rivers. The San Diego Chargers will be without tight end Antonio Gates on Sunday against Tennessee. Gates hurt his ribs against the Raiders last week. He practiced Friday on a limited…Source: ESPN.com
Troy Polamalu, Antonio Gates headline late game inactive listsThere is no shortage of big names on the late game inactive lists. The New York Jets will be without cornerback Darrelle Revis and tight end Dustin Keller, while the Pittsburgh Steelers' defense will have to make due without outside linebacker James Har…Source: yahoo.com
It's Now a Football Dream for Jets Clyde GatesFLORHAM PARK, N.J. — The story of Jets wide receiver Clyde Gates was supposed to be told on the hardwood and not the gridiron. Meet the soft-spoken and shy Gates, a second year wide receiver who last year played 15 games in Miami. Gates is one of the unSource: thejetsblog.com


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SO how will we remember the Challenge Cup final of 2013?
That depends which side of the fence you are standing on.
It was certainly a low-scoring affair that Wigan had the better chance of winning because of their better ball retention and superior kicking game. On a day in which the heavens opened with some intent, the pre-match downpour was reminiscent of the 1968 Watersplash final, although the pitch at the new Wembley stood up to it better than the old.
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The canon is shot
Author: Anon
… or is it just new and improved? MLA 2010 is hoping to confirm soon that Mr Harold Bloom will present a keynote session entitled "I Was Wrong: We Should Include Women and People of Color in the Canon." This is the rumored title of the opening chapter of his rumored book The New & Improved Western Canon.
2 Responses to "The canon is shot"
Dame Rhetorica says:
Here's hoping we can pick up signed copies at the book exhibit. I always new Harry had it in 'em. Good to see the ol boy has finally come into full bloom.
Julie says:
I'm looking forward to receiving my mankini…


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|Ameiko Kaijitsu aka Navior
"It is my intention to claim a fair portion of the treasure once we have made an attempt to locate its owners, of course." Malan gives a sideways glance and grin at Blue Rajah. "You and Ameiko being so well traveled, we would ask if you wouldn't mind taking a look at some of the treasure for us? Your vast knowledge could be instrumental in locating the treasure's owner. We can bring some of the items here for the two of you to peruse if it would make it easier for you."
"I'd be happy to help out," Ameiko says. "I can go round to the garrison with you after breakfast in the morning if you like. Things are usually pretty quiet at that time of day." She glances around a bit. "So, uh, where's Melon?"
|Corinna Valdemar
|Ameiko Kaijitsu aka Navior
The night winds down and gradually, you each head up to bed for the night. As Ameiko is cleaning up, she discovers Melon's hiding place and helps her up to a proper bed to sleep in. The night passes quietly.
After dinner, her mother bids her good night and heads up to her room.
The night passes quietly.
DAY'S XP: 814 each.
CURRENT TOTALS: Blue Rajah: 2415; Corinna: 2015; Gilfroy: 2415; Malan: 2015; Melon: 2015; Tevyn: 2015
Welcome to level 2!
You awaken in the morning to the sound of light rain tapping on the roof and windows. The smells of bread baking and bacon frying waft up from the kitchen below.
|Corinna Valdemar
|Gilfroy Fezziwig
Gil peers down the stairs, trying to determine if any of the group is yet at breakfast. Assuming there is, he casts [i]haunted fey aspect[/b] within the shadows of the stairway, and bounds down with an energetic "Good morning!!" to all below.
Wild and crazy illusions surround the gnome, making him look like some wild sylvan creature.
Having resisted the temptation to enjoy the Dragon's hospitality the night before, Tevyn arrives at the inn just in time to see Gil appear, illusions flitting about him in a wild succession.
He blinks, rubs at his eyes and raises a hand in greeting. Then he makes his way over to a table, sits and looks about for Amelia and her fresh bread.
|Melon Sash
To determine what Melon spontaneously recalls about the recent treasure after a good night's sleep and being able to think clearly after being sickened all day.
Knowledge (local) - who can it belong to? 1d20 + 1 ⇒ (11) + 1 = 12
Knowledge (geography) - where can it belong to? 1d20 + 1 ⇒ (15) + 1 = 16
There's a sudden thump, followed by an irate mewing. It doesn't take too long then, a minute or so later Melon comes in absent-mindedly rubbing the side of her head. Her other hand is feeding her some bread, while her mouth is making a concerted effort to be free of the incessant bread meddling that keeps interfering with her ability to speak. "- Ameiko! - there you - are!" She grins, a smile that doesn't quite hide the fact that she's just realized that she can smell herself. "- Ameiko! - I - tell you! Th- There's - stuff!" She swallows, then adds, "Can I run a bath?"
I just looked at my earlier post and realized I'd said something about Amelia. Amelia? Who's Amelia? That should have been Ameiko. Damn.
Tevyn winces at Melon's arrival. Between the visual stimuli of Gilfroy's illusions and Melon's voice, he feels like he's somehow become hungover.
"We told Ameiko about the findings last night. She's going to look at what we found when she has some free time later this morning." He says.
|Melon Sash
|Gilfroy Fezziwig
I should point out the illusion only lasts about ten seconds after his appearance, though he is quite taken with the new spell, and recasts it often throughout breakfast.
"No, not this, but later on I might show you what does happen to gnomes who get really excited about receiving new blessings from Sivanah."
|"The Blue Rajah"
Rajah wakes up with the dawn. After going through his morning prayers, he prepares for the new day. Making himself presentable, "Well, let us see what this day has in store for us, shall we?" He says to himself as he takes his leave, making his way over to the Rusty Dragon.
As he walks through the door, "Morning, all. The Dawnflower has blessed us with another fantastic day!" He says, unbothered by the light rain.
|Melon Sash
"Tears of joy, no doubt," Melon grins, nudging Gilfroy.
"Excuse me," she adds, "I'm going to run a tub and get squeaky. No peeking. Unless you want to see me naked." She goes off and helps herself in the kitchen to set up a pot to the boil to get the right heat for her bath. Some ten minutes later she's reclining in a big tub behind a loosely drawn curtain, a couple of toes sticking out, and heaving a contented sigh.
|Ameiko Kaijitsu aka Navior
Ameiko does a quick double-take upon seeing Gilfroy come down the stairs. She recovers quickly, however, and goes about serving breakfast. When she places a plate in front of Gilfroy, she says, "Would the...uh...ghosts?...like something too?" She smirks and addresses the rest of the group, "Just let know when you'd like me to go down to the garrison to look at those items."
She shakes her head and rolls her eyes. "Oh well. Belven will soon realize you're just as bad as your mother was. At least he's planned ahead just in case." She starts down the stairs again, then stops. "Oh, you don't know what I'm talking about, do you? Well, let's just say he's made arrangements just in case you live out your dreams with that Varisian or your so-called friends."
|Corinna Valdemar
Tevyn gives his customary half smile as Ameiko brings breakfast out. "I believe we'll be heading over there as soon as we've finished our fine meals and Corinna returns from her family's estates. Melon is quite keen to show you a sword that almost chopped Malan in half."
Edit to fix Ameiko: There is no explanation for the things my brain does.
She sighs. "But I shouldn't have told you any of this anyway. I don't know why I stopped to... Oh, it just makes me so angry that you..." She struggles, unable to come up with the right words, and then stomps away down the stairs, muttering angrily to herself. As she reaches the bottom of the stairs, she yells angrily without looking back, "Have fun in the swamp!" She then stomps off to the dining room for breakfast.
When Corinna gets to the dining room, Alil has regained her composure and is seated primly at her spot. She doesn't speak to or acknowledge Corinna when Corinna enters. Corinna's mother and the rest of the family are already there.
|Corinna Valdemar
She composes herself before entering the dining room but can't keep an amused smile off of her face as she greets her mother. Her eyes twinkle in a way that she knows must drive Alil up the wall as she glances across the table at her. If the worst they can threaten her with is not to allow her imaginary boyfriend to visit the family home... well, honestly! They might as well forbid her from feeding her pet dragon under the table or not let her keep a hippogriff in the stables. She amuses herself during the meal by imagining what 'precautions' exactly Uncle Belven has taken: some sort of permanent antipathy effect over the doorpost specifically worded to deny access to all men romantically involved with Corinna Valdemar or a custom-built reverse geas? The academic exercise -- as well as the thought that Alil sees her as some sort of dangerous seductress -- keeps her in an excellent mood throughout breakfast.
|Gilfroy Fezziwig
"Careful, Ameiko. While this is just an illusion, the shadow spirits that are drawn to my connection to Sivanah are very real indeed, and they've recently grown stronger. If you offer them something, they might just take it, and that wouldn't be good for anybody."
As a gnome with the alternate favored class bonus for oracle, he gains +1/two oracle levels to his curse level to determine when he gets the good stuff. He also gets +1/two non-oracle levels added to his curse level. I wasn't sure if such things are considered fractionally or not. If so,then his curse is at level 2.
As a gnome with the alternate favored class bonus for oracle, he gains +1/two oracle levels to his curse level to determine when he gets the good stuff. He also gets +1/two non-oracle levels added to his curse level. I wasn't sure if such things are considered fractionally or not. If so,then his curse is at level 2.
That's an interesting thought, but I would have to say that no, they're not considered fractionally, since similar cases with base attack bonuses and saving throw bonuses are not considered fractionally. For example, the BAB progression for oracles is based on level X 3/4, rounded down, while the sorcerer progression is based on level X 1/2, rounded down. For a multiclass character, the rounding happens first, so a sorcerer 1/oracle 1 ends up with a BAB of +0 (3/4 rounded down to 0 plus 1/2 rounded down to 0). If the adding happened first, a sorcerer 1/oracle 1 would end up with a BAB of +1 (3/4 + 1/2 = 5/4, which rounds down to 1). I think it should work the same with the oracle curse.
I know that there are some people who play with house rules that have the adding happen first before the rounding, such that a sorcerer 1/oracle 1 ends up with a BAB of +1. However, that's a little too math-intensive for many people, so I prefer to just go by the book. That way, people just have to look at the values on the individual class charts and add them together, without having to worry about multiplying each class level by various fractions.
In short, Gilfroy's curse level is still 1.5, which rounds to 1. :)
|Gilfroy Fezziwig
|Ameiko Kaijitsu aka Navior
But I can still fluff it out to say that they're a little stronger, just like I plan to fluff it out tat as he rises in level, the "shadow spirits" get more prominent and meddlesome, even though nothing happens mechanic-wise.
That's fine.
"I'll keep that in mind," Ameiko says, eyeing Gilfroy a touch suspiciously. Turning to Tevyn, she says, "A sword, you say? Well, I'm pretty good with a rapier, but otherwise, I have to admit, I'm not much of a sword person. Still, I'll be happy to take a look at it."
She finishes serving the breakfast and returns to the kitchen.
As Corinna is passing by Sandru's caravan on her way into Sandpoint, she can see that he, Bevelek, and Vankor are currently tidying up from their own morning breakfast. Sandru calls out to her as she walks, "Corinna! Hold on a moment!"
He says a few things to Bevelek and Vankor, then hurries over to catch up to Corinna. "I believe we're headed the same way," he says. "I told your friends I'd take a look at the items you all found. I might have a few contacts who might know who they belong to."
|Corinna Valdemar
Still lost in her own amused thoughts when Sandru hails her, she unknowingly looks younger and more good-natured than she has in years. Charisma check 1d20 ⇒ 18 "Oh, Mr., er, Vhiski," she twinkles from beneath her hood, imagining what Alil would think if she came along the path at this moment, "you've already heard about that, have you? I forget how quickly news spreads in a small town like Sandpoint. I suppose we'll have people lined up in the streets outside the sheriff's office, waiting for the unveiling. Well," she amends, glancing out at the damp weather, "perhaps the rain will keep the crowds down."
Corinna's mother says she looks forward to taking that walk. She also agrees to let Belven know where Corinna is if he asks.
Later, with Sandru:
"News does indeed spread fast," Sandru says. "Many people saw you bringing the chest in, and then they tell others, who tell still others. Can't blame them really. There's not much else to do around here other than gossip." He smiles at her. "Still, in my case, I learned it direct from your friends at the Rusty Dragon last night. It sounds like you found some particularly valuable things."
You finish up breakfast (and Melon finishes her bath), grab your things, and prepare to head out to see the sheriff. Ameiko takes a moment to give some directives to one of her staff and then joins the rest of you.
The rain is letting up a little. It's not much more than a drizzle at the moment. People are going about their normal daily routines without paying the weather any mind. Many people on the street nod and say hello to Ameiko as you pass. She stops to say a brief word to several of them, slowing you down somewhat. A walk that should only take a minute or two ends up taking around fifteen minutes instead.
Part way there, you're joined by Corinna and Sandru walking together. They come up from behind, easily catching up because of the slow pace set by Ameiko.
"Good morning," Sandru says cheerfully.
|Corinna Valdemar
|Corinna Valdemar
Many people on the street nod and say hello to Ameiko as you pass. She stops to say a brief word to several of them, slowing you down somewhat. A walk that should only take a minute or two ends up taking around fifteen minutes instead.
Oh, right. Because she's so popular and charming and likeable with her high Bard-y Charisma. I lived next door to That Girl my freshman year in college. Her room was a constant parade of admirers she never even tried to attact. She was friendly and pretty and smart and in a lot of clubs and good at sports. She was so impossible to dislike we all despised her. :P
Part way there, you're joined by Corinna and Sandru walking together. They come up from behind, easily catching up because of the slow pace set by Ameiko.
"Good morning," Sandru says cheerfully.
Corinna. looking uncharacteristically happy, blushes a little as the pair joins up with the party, inwardly wishing it were a bit farther from her house to the sheriff's office. Guess who made her Charisma check today! ;D
|Melon Sash
I have no idea what you're talking about. ;)
But, come to think of it, did Melon pick up anything with her knowledge checks earlier?
"You shoulda seen it! Did they tell you!?" Melon's aglow with excitement as she talks with Ameiko, "There was this huge skeleton. Well, more sized like us, but it felt huge! Wore some strange armor and - apparently this is strange - it talked! As if it was protecting something. ...I guess it wasn't very nice of us to unprotect the things, but maybe some good will come of it. He's resting now in peace, I hope."
|Corinna Valdemar
|"The Blue Rajah"
I confess. I HAD to look once she mentioned she made her charisma check. How could I resist? Especially with it being such a red-letter occurence. ;)
Rajah looks curiously at Corinna, then with a look of understanding as she explains her reason for being so chipper. "It is quite the beautiful day! Good morning to you both. Well, it appears that rest and a warm meal has done wonders for you, Corinna. I'm glad."
To determine what Melon spontaneously recalls about the recent treasure after a good night's sleep and being able to think clearly after being sickened all day.Knowledge (local) - who can it belong to? 1d20 + 1
Knowledge (geography) - where can it belong to? 1d20 + 1
Sorry, missed these. So now we get the other end of the skill believability stretch with the character who one moment doesn't know how to do something and the next moment does. :)
The Knowledge (geography) roll is enough to finally justify Melon's belief that the items might come from Tian Xia. Given that knowledge, she can then reason that the items might have belonged to Ameiko's family. From the Knowledge (local) check, she would also know that there is no other family of Tien descent in the vicinity.
As you reach the garrison, Sheriff Hemlock comes out to greet you all. "Good morning," he says. "I see you've already brought along some people who might be able to help." He nods to Ameiko and Sandru. "Glad you two could come out to help. Shall we go in?"
He leads you into the garrison and back to the same room you were in yesterday evening. The chest is in the same place on the floor in the middle of the room. "I placed the extra sword you were carrying, Melon, in the chest with the rest of the items. It seemed the best place to store it for now."
Tevyn nods. "Good morning, Sheriff. Thank you again for holding on to these items."
Yeah, those sudden pieces of knowledge appearing in a PCs head along with suddenly knowing a language, seemingly out of nowhere. At the table, I always have that stuff develop gradually rather than all at once (PCs actually have to study a language, for example, to add it to their repertoire) but it's just not practical in pbps. Suspension of disbelief for the win!
Yeah, those sudden pieces of knowledge appearing in a PCs head along with suddenly knowing a language, seemingly out of nowhere. At the table, I always have that stuff develop gradually rather than all at once (PCs actually have to study a language, for example, to add it to their repertoire) but it's just not practical in pbps. Suspension of disbelief for the win!
I do the same in my tabletop games, but like you say, it's just not practical in pbps.
The sheriff bends over and opens the chest. "Well, there you have it," he says. "Ameiko, Sandru, what do you think?"
Ameiko and Sandru kneel down on opposite sides of the chest and begin pulling out items to examine. "Lots of fireworks," Sandru says. "We could look for people or families that are known for liking fireworks a lot."
Ameiko Knowledge (geography): 1d20 + 1 ⇒ (4) + 1 = 5
Ameiko pulls out the cold iron sword and unsheathes it. "Is this the sword you were talking about, Melon?" She looks carefully at the blade, then shrugs. "I suppose it could be of Tien make. It's certainly not local, but honestly, I don't really have a clue beyond that. If my father were still alive, he might know."
|Melon Sash
I figure getting in all the skills in the first few levels is best - that way the suspension of disbelieve is reduced the most. And Melon can blame the stinging nettles that addled her brain in the cave.
"Nope, not that one," Melon points out the other weapon, "though they are both the same type of short sword - this other one has some special magic on it. Don't know how it got a little bit broken though. Malan's body definitely didn't give it any resistance."
|Ameiko Kaijitsu aka Navior
Ameiko Perception: 1d20 + 7 ⇒ (12) + 7 = 19
Ameiko puts down the cold iron sword and picks out the other one. Unsheathing it, she examines it. "Different material for the blade, but otherwise pretty much the same as far as I can tell. I'm sure this loose hilt can be easily fixed, but that can probably be left for the rightful owner to take care of. He or she is certainly going to have enough money for it." She places the sword back in the box.
Tevyn frowns. "From what you and Melon have said, it doesn't sound likely that the rightful owner will be found. At least, not here. If these weapons are truly as exotic as you say, I can't think of anyone else in Sandpoint who could claim them."
He pauses thoughtfully. "Does anyone know anything about fireworks? What happens when fireworks get old?"
|Melon Sash
|Corinna Valdemar
|Sandru Vhiski aka Navior
Sandru finishes examining the contents of the chest. "The ships' names might be helpful," he says, placing the last firework down on the floor, "but that's only if your suggestion that the ships and the chest are linked is correct. If they're not, the names could send you down a wild goose chase. It would better first to find any kind of identifying marks on this chest or these items."
Now that he has emptied the chest, he begins examining the outside, lifting the chest up slightly to peer at the bottom as well. "This thing's a bit unwieldy," he comments. "Anyone care to give me a hand?
Sandru Perception: 1d20 + 7 ⇒ (3) + 7 = 10
Anyone else who wishes to examine the chest or any of the individual items, go ahead and do so. Provide me with Perception rolls for them.
|Corinna Valdemar
|"The Blue Rajah"
|Melon Sash


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Zaidi, Anita K. M. MB BS, SM*; Tikmani, Shiyam Sundar MB BS*; Warraich, Haider J. MB BS*; Darmstadt, Gary L. MD†; Bhutta, Zulfiqar A. MB BS, PhD*; Sultana, Shazia MB BS, MSc*; Thaver, Durrane MB BS, MPH*
Background: Sepsis in the neonatal period is a major cause of child mortality in low-income countries. Hospitalization and parenteral penicillin/ampicillin and gentamicin therapy are recommended for management. Many families, however, are unable to access hospital care, and most home-delivered newborns who develop sepsis die without receiving antibiotic therapy. Appropriate community-based therapy in such situations is undefined. We compared failure rates of 3 clinic-based antibiotic regimens in 0- to 59-day-old infants with possible serious bacterial infection whose families refused hospitalization in Karachi communities with high neonatal mortality rates >45/1000 live births.
Methods: Eligible infants were randomly assigned to 7 days of: (1) procaine penicillin [50,000 units/kg once daily (OD) by intramuscular injection (IM)] and gentamicin (5 mg/kg OD IM) reference arm, (2) ceftriaxone (50 mg/kg OD IM), or (3) oral trimethoprim-sulfamethoxazole (TMP-SMX) at 10 mg/kg/day divided twice daily and gentamicin IM OD. Primary outcome was treatment failure, defined as death, deterioration in clinical condition during therapy or no improvement after 2 days.
Results: Possible serious bacterial infection was diagnosed in 704 infants, among 5766 screened. Among 434 (61.6%) randomized to clinic-based therapy, there were 13 of 145 failures with penicillin-gentamicin, 22 of 145 with ceftriaxone and 26 of 143 with TMP-SMX-gentamicin. Treatment failure was significantly higher with TMP-SMX-gentamicin compared with penicillin-gentamicin [relative risk 2.03, 95% confidence interval: 1.09 – 3.79] by intention-to-treat analysis. Differences were not significant in the ceftriaxone versus penicillin-gentamicin comparison [relative risk 1.69, 95% confidence interval 0.89–3.23). By 14 days, there were 2 deaths in the penicillin-gentamicin group, 3 in the ceftriaxone group and 11 in the TMP-SMX-gentamicin group [relative risk 5.58, 95% confidence interval: 1.26–24.72 (group 3 versus 1)].
Conclusion: When hospitalization of sick infants is unfeasible, outpatient therapy with injectable antibiotics is an effective option. Procaine penicillin-gentamicin was superior to TMP-SMX-gentamicin. Ceftriaxone is a more expensive option, and may be less effective, although this requires further research.
© 2012 Lippincott Williams & Wilkins, Inc.
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Reasonable played with condition.
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If you apply the first derivative test (putting partial derivatives equal to 0), you see that the only critical point of f(x,y)occurs at the origin. If you apply the second derivative test (calculate the second partial derivatives and look at ), it tells you that there is a local max/min at the origin (depending on whether is negative or positive) if that expression is positive, and that there is a saddle point if it is negative.
On the other hand, if you look at the formula obtained by completing the square, you get exactly the same information: if then one of the squares is positive and the other one is negative, so there is a saddle point at the origin. If then both squares are positive, and the function will have a local max/min at the origin depending on whether a is negative or positive.
So it looks as though the aim of this exercise is to persuade you that the second derivative test works, by seeing that it gives the right answer in this case.


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Alumni Entrepreneurs
Stefan Schinzinger, 1978
San Francisco Hat Company, Schinzinger Kellman Design
Type of Business
Sales and Related
Date of Operation
Description of Business or Organization
We design and make wonderful, practical & functional headwear. Our hats can be found all over the world from Japanese trend boutiques to Orvis fly fishing shops and through mail order firms such as TravelSmith.com. As well as our own brands we do a lot of private label - We've worked with Issey Miyake, Barneys, DKNY, Smith & Hawken, Martha Stewart, Mountain Hardwear among others. We are a small group of craftspeople who embrace traditional as well as modern tools and techniques. It's not easy being an apparel manufacturer!
Contact Information
PO Box 1817
San Leandro, CA
Please describe any patents you hold on inventions or processes and where those are held and when you got the patent.
I received a patent for a particular use of tape in the assembly of earrings.
How did Evergreen prepare you for your professional life?
In every way (except bookkeeping)


text:
Kelly Bennett
Kelly Bennett loves fish. "Fish are fun and funny," she says. "Just watching them makes me laugh." When she's not writing, Kelly creates tile mosaics and digs in her garden. She has two grown children, Max and Lexi, and lives in Texas with her husband, Curtis, and their goldfish--whom she would never trade.
Noah Z. Jones loves drawing fish of all shapes and sizes, but especially smallish orange ones named Norman. This is his first children's book. He lives in coastal Maine with his wife, Diane, and their tuna-lovin' cat, Mabel.


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Tue, Jul 17th 2007 3:12pm
Filed Under:
ask, google, microsoft, yahoo
Last month, a much-hyped partnership between Salesforce.com and Google turned out to be a real snoozer, when it was revealed that the tie-up would simply offer Salesforce.com customers a better way to manage their AdWords campaigns. One aspect of the deal that was troubling was that it belied the myth that all these various web services are so easily mashed up. After all, why should Salesforce.com have to sign a deal with Google to offer AdWords management? Ideally, any company would be able to offer this functionality. Today, Microsoft announced enhancements to its own AdManager service, which allows users to manage advertising campaigns on Microsoft's search. Now, however, customers can buy ads for Live search and for Ask.com. It's really great that Microsoft is taking this big tent approach, acknowledging that there are other search engines out there that customers would like to buy ads on, but it's still missing a couple -- Google and Yahoo come to mind. Ultimately, if it wants AdManager to be a valuable service, then it should allow customers to manage as many different campaigns as they want, through any search engine. This piecemeal approach, allowing customers to buy ads on different Microsoft-approved sites, isn't going to get the company very far in its software plus services strategy.
If you liked this post, you may also be interested in...
- Senior Brazilian Court Says 'Right To Be Forgotten' Cannot Be Imposed On Search Engines
- Convicted Felon Ask Google To Delist Multiple Government Websites Because His Name Is Protected By 'Common Law Trademark'
- Woman Sues Google Because SEO Guy Wrote A Mean Blog About Her Company
- Granted Warrant Allowed Feds To Force Everyone At Searched Residence To Unlock Devices With Their Fingerprints
- Judge Tears Apart Law Enforcement's Ridiculous Assertions About 'Suspicious' Behavior
Reader Comments (rss)
(Flattened / Threaded)
TheDock22, Jul 17th, 2007 @ 3:26pm
The first steps....The first steps towards recovery is admittance. ;)
[ reply to this | link to this | view in thread ]
Craig Ferrante, Jul 17th, 2007 @ 4:41pm
Atleast they triedAtleast Microsoft is giving you a option now. Id like to see google and yahoo give you the full control of the 3rd party advertising sites not just the option to turn ads on or off to 3rd party sites.
I use the big 3 to advertise on and google i feel is the easiest to manage then microsoft and then yahoo. Tried ask's and went back to google to manage those ads...
[ reply to this | link to this | view in thread ]
Steven, Jul 17th, 2007 @ 4:47pmForget Microsoft...
[ reply to this | link to this | view in thread ]
business, Jul 17th, 2007 @ 5:12pmI find it intresting that many of the people in the tech world today, wouldn't have their current jobs if it wasnt for a Microsoft product. Would these also be the same people badmouthing Microsoft every chance they get? or would the one's who are flinging their insults be those of a generation who do not yet have six-figure incomes.
As always though, there are exceptions to every rule - but with 90% desktop-share in a tech-driven world, makes anyone who knows the in's & out's of Microsoft products, much more richer than the person who does not - or - will not educate themselves in such.
Business as usual...
[ reply to this | link to this | view in thread ]
A Torontoan, Jul 17th, 2007 @ 5:40pm
Re:I find it interesting that many people are so willing to shill for corporations that in the long run stifle innovation to make a buck. Most monopolies are good at making money for people involved with them. We don't owe microsoft a damn thing.
[ reply to this | link to this | view in thread ]
Trvth Jvstice, Jul 17th, 2007 @ 5:51pm
Why?Why do so many of you hate big business? The reason they became such a big company is because they were good at what they did, made good products and therefore became successful.
I bet if Ubuntu started selling their product and became enormously successful, you'd be against them also.
[ reply to this | link to this | view in thread ]
The Grapevine, Jul 17th, 2007 @ 6:16pm
open standard, open search, open mindWe applaud Microsoft on their learning that the world does not revolve around them, especially in Search.
It is important that your customer has choice and simplicity when using any tools, thus allowing Ask.com is a step in the right direction. Ignoring Google and Yahoo is obviously a childish taunt, and shows pretty well that those 2 Search engines are the most popular over MS Live services.
Keep in mind that Ask.com is part of the Barry Diller empire, as is Expedia whch used to belong to MS, and thus Microsoft is more easily able to adopt them as an added search component on AdManager.
But sooner or later, if Microsoft expects to make any headway with this search advertising service they will have to admit Google and Yahoo to the party.
Meanwhile its business as usual in Redmond, keeping heads in the sand, ignoring popular wisdom, and not allowing much consumer choice.
[ reply to this | link to this | view in thread ]
Haywood, Jul 17th, 2007 @ 8:15pm
Baffles me how it is going to workGoogle isn't a verb for nothing. I don't personally know anyone who still uses anything else. The only reason the others still exist is inertia. I do use MS search once every time I install Windows, when IE comes up the first time. IE
defaults to MS, where I promptly search for Google then make it the home page. One more search for Firefox, now I'm IE free except for the occasional Firefox unfriendly site. Download the Google tool bar and Ad-block and I'm good to go. Ads? what ads.
[ reply to this | link to this | view in thread ]
Craig, Jul 18th, 2007 @ 8:23am
http://luckybonza.comThat's why they made a little $6B purchase this year of a little Seattle digital marketing firm called aQuantive.
[ reply to this | link to this | view in thread ]


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Silk ribbon embroidery stitches are similar to those used in crewelwork, but ribbon stitches allow you to make textured leaves and dimensional flower petals.
This embroidery method is used most often to simulate floral effects, so most of the stitches are for leaves or flowers. However, I'm sure you could adapt the ribbon techniques for use in any design where you want texture.
Just keep in mind the fact that ribbon behaves a little differently than thread.
When you begin silk ribbon embroidery stitches, it's best to lock the ribbon onto your needle so it doesn't slip out. Simply poke the needle through the ribbon near the end.
Find instructions for making a ribbon rose here.
Obviously, the above instructions are for hand sewing. If you'd rather machine sew simulated silk ribbon embroidery stitches, try free motion embroidery.
Lay the ribbon on top of hooped fabric and tack it into place with stitches in clear thread. Fold the length of ribbon in half to start so that you have two ends to wok with and overlap. Since the ribbon doesn't actually go through the fabric with machine silk ribbon embroidery stitches, you can use larger threads and a more densely woven cloth, if you like.
Here you can learn some new skills and share your ideas about your favorite ways to embroider.
Read about me.
We have hundreds of visitors every day from around the world.
I love to embroider!


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Complete The Look
Rated 5 out of 5 by StephanieC from Perfect patriotism for my state! I LOVE the Maryland scarf! I mulled it over for a year (not really wanting to pay over $100 for it), and recently I decided it's now or never, because once they stop selling it, I just know that I'd be kicking myself for not having gotten it. I am glad I finally bit the price-bullet and purchased it. I LOVE it so much!
Date published: 2016-08-01
Rated 5 out of 5 by LaurenElizabeth from Favorite Scarf! I absolutely adore my NC Murfee. I typically try to hold out and purchase "non-essential" items like scarves on sale, however I decided to splurge since this is such a unique and meaningful piece and I couldn't be happier. Now, only if it weren't too hot to wear it....I guess this gives me a reason to look forward to October :)
Date published: 2016-05-16
Rated 5 out of 5 by Susan90 from Soft and cute! I absolutely love my Murfee Scarf in Peri Blue Virginia! It's incredibly soft and keeps me perfectly warm.
Date published: 2016-05-06
Rated 5 out of 5 by Appleed from Murfee scarf Absolutely love it! Great way to represent my home state in a stylish way. I think it they did a line of tote bags of the state patterns, i would purchase one!
Date published: 2016-04-02
Rated 5 out of 5 by TRICIACATHERINE from Maryland & Virginia I purchased both the Maryland and Virginia state scarves, because I was born in Maryland (and love it, obviously) and I have been to Colonial Williamsburg more times than I can count! The scarves are so beautiful and vibrant.
Date published: 2016-03-30
Rated 5 out of 5 by SusanD from Perfect Florida Scarf These were gifts and both ladies loved their Florida scarf! One wore hers to dinner at night in Florida. Every snowbird should own this scarf- perfect for cool nights and air condotioned events.
Date published: 2016-03-13
Rated 5 out of 5 by MiaB from Home Away From Home! Brilliant colors, nice state specific details. It's a great way to feel like you're home away from home. Would make a perfect gift. Now I want to get the Chicago & Nashville versions as well!
Date published: 2016-01-29
Rated 5 out of 5 by Bluebellegem from The best state scarf! I was visiting Virginia and this scarf was just one of those pieces I grabbed and couldn't leave the store without. In my opinion, it's by far the most beautiful state scarf. I've been collecting them in my travels and this is hands down my favorite!
Date published: 2015-07-14


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HOME > Projector News
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Projector News and Industry Commentary
Bulletins about upcoming product reviews and releases, tradeshows, new technology and advanced product features as well as our thoughts and observations on all things related to projectors.
A Whole New Concept in Projector Design
Evan Powell — Aug 29, 2003
We are still working on the review of the Studio Experience Premier 50HD. I was hoping to get it up by today, but it's not quite complete. It will be up after the holiday weekend.more
HT Questions and Answers
Evan Powell — Aug 22, 2003
The recently updated article on aspect ratio formats, Your Biggest Decision: 4:3 or 16:9? prompted quite a bit of email. One of the most frequent questions was related to resolution--don't 16:9 projectors deliver higher resolution for HDTV and widescreen movies than 4:3 projectors? Click here for the answer; it may surprise you.
Another question we get frequently--what is the ideal screen size and viewing distance? I just recently posted some thoughts on this issue that I hope will be helpful if you are planning your new home theater.more
Format Decisions
Evan Powell — Aug 15, 2003
NEC has just announced performance upgrades to the LT240 and LT260. The new editions are dubbed the LT240K and LT260K respectively. The LT240K in particular will be of keen interest to home theater buyers budgeting in the mid-$2,000 range. Our review of the LT240K has just been posted.more
4:3 or 16:9 Theater?
Evan Powell — Aug 8, 2003
We get a lot of email asking which is the best projector, A or B? Quite often one of them is native 4:3 and the other is 16:9. There is no way to answer the question "Which is best?" until the buyer decides if he or she wants to set up a 4:3 or 16:9 theater.more
News on the Epson TW100
Evan Powell — Aug 1, 2003
The review of the new InFocus Screenplay 5700 has been posted. This is a terrific new offering from InFocus, and worthy of your close scrutiny if you are budgeting up to $5,000 for a projector.
We have no word yet on when we will get a replacement of the Optoma H76 that was damaged in shipment. I will let you know on this page when we have information on this. We still plan to review it as soon as possible...I just don't know when that is at the moment.more
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Eom, Youngsub MD; Han, Ji Yun MD; Kang, Su Yeon MD; Kim, Hyo Myung MD, PhD; Huh, Kuhl MD, PhD; Song, Jong Suk MD, PhD
Purpose: To report a case of calcium hydroxyapatite crystals in the anterior chamber of a patient with renal hyperparathyroidism.
Methods: Case report.
Results: A 54-year-old man visited our clinic with mild ocular pain and decreased visual acuity in his left eye. A slit-lamp examination showed peripheral corneal band keratopathy and multiple white crystals in the anterior chamber. The patient had chronic renal failure and was on regular hemodialysis treatment for 12 years. He had previously undergone total parathyroidectomy because of secondary renal hyperparathyroidism. Aqueous humor analysis showed elevated phosphate levels. Multiple crystals were removed using a manual irrigation and aspiration cannula and were found to be calcium hydroxyapatite crystals on elemental analysis using energy dispersive x-ray spectroscopy. Ocular pain and visual acuity improved and corneal edema and ocular inflammation decreased after the surgery.
Conclusions: Calcium hydroxyapatite crystals can form in the anterior chamber of the eye in a patient with renal hyperparathyroidism.
© 2013 by Lippincott Williams & Wilkins.
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