text:
Amazon Multiple Will Compress, but How?
So this month, all the big cloud-related stocks have fallen faster than the market. Rackspace(RAX) , Red Hat (RHT) and VMWare(VMW) are all down over 10% this month, a move that has accelerated as the month has gone on.
One result is that their price-to-earnings multiples are almost getting affordable. VMWare is down to 55, still rich but more in line with the 21.74 of EMC, which owns 80% of it.
Only one major cloud player hasn't played this game. Amazon.com(AMZN) is down only 5% for the month.
But that has to change, especially with news that both Google(GOOG) and Microsoft(MSFT) will target Amazon with new cloud offerings -- and that both are willing to compete on price.
Why does that matter? Because Amazon Web Services has become the de-facto public cloud standard, its Application Program Interface essential to deployments. AWS is why Amazon sells at a cloud multiple, not its retailing operation. Also, investors know that Amazon has been willing to forego short-term profits in order to maintain its high market share.
It's one thing to play price games with Rackspace, a much smaller competitor. It's something else to try and do it with Google and Microsoft.
Of course when I wrote about this issue in March, Amazon was sporting a price-to-earnings ratio of 134. Even with its latest drop in price that's now at 176, thanks to its most recent earnings .
Rather than look at net income, Amazon bulls are looking at gross profit, and how that compares with revenue. In its March quarter, Google Finance reports Amazon brought 23.9% of revenues to the gross profit line, although its actual net was just $130 million. In the previous quarter it brought 20.6% of revenues to gross profit.
To compete with Google and Microsoft Amazon will be pressed on gross profit this quarter, too, and for some time to come, especially if it wants to grow the top line. Not to mention WalMart(WMT) , which also managed to bring 24.6% of revenue to gross profit last quarter, and which has enormous ambitions in online retailing.
All that spells earnings compression to me, although Amazon doesn't use its stock as a currency the way many companies do. Its most recent acquisition, logistics robot maker Kiva Systems, was made for all cash in March.
Which means I expect Amazon stock to be under pressure through the year. I own a few shares in my retirement account, and I'm keeping them. But I won't be adding to that position until the company proves it can handle the new pressures.


text:
April 4, 2013: A long time ago, in a galaxy far, far away, a star detonated with enough energy to briefly shine with an intrinsic brightness of one billion of our suns. The beacon of radiation arrived at Earth 10 billion years later and was captured in a Hubble Space Telescope deep survey of the universe. It is the farthest, and earliest, supernova of its type detected to date. More than simply an example of the ancient fireworks in the young and effervescent universe, the supernova belongs to a special class of stellar detonations that are so reliably bright, they can be used as intergalactic milepost markers.
Supernovae like this one provided the first observational evidence that the universe is expanding at an ever-faster rate. Our understanding of the accelerating universe, however, is only as solid as the reliability of supernovae as solid yardsticks for measuring cosmic distances. This record-breaker is so ancient it can be used to test competing theories about how such supernovae exploded in the universe's early days and compare them with nearby supernovae seen today. Its discovery is part of an ongoing program, where different teams of astronomers are using Hubble to push ever farther back into the early epoch of star formation.See the rest:

subset: commoncrawl


text: Just Bookends coupons are a great way to get discount coupon codes, free shipping coupons, promo coupons and other extras. Online coupons have special promotional codes and discount codes - these codes unlock the door to promo discounts and big savings. Free Just Bookends coupon codes, online coupon codes, promo codes and free shipping codes can be found below. Enjoy the best savings when using Just Bookends online.


text:
Neutrogena Healthy Skin SPF15 Anti-Wrinkle Cream - 2 pk. - 1.4 oz.
About this itemClinically proven to reduce the look of fine lines and wrinkles
Neutrogena® Healthy Skin® Anti-Wrinkle Cream SPF 15 is a daily moisturizing cream clinically proven to begin visibly reducing the appearance of fine lines and wrinkles in one week. It also helps prevent premature signs of aging from the sun for healthier, younger-looking skin.
Visibly reduces the appearance of fine lines and wrinkles: Retinol, the purest form of Vitamin A, works deep within the skin's surface where wrinkles develop.
Helps prevent premature signs of aging: Broad-spectrum UVA/UVB SPF 15 sunscreens help prevent premature signs of aging such as fine lines, wrinkles and age spots caused by everyday exposure to the sun's damaging rays.
Softens and smoothes skin: Pro-vitamin B5, vitamin E and special moisturizers boost moisture levels for softer, smoother skin.
Won't clog pores: Oil-free formula absorbs quickly and won't clog pores, which can cause breakouts.
- 2 pk. - 1.4 oz.
- Original formula
- #1 Dermatologist recommended anti-aging brand
- Oil-free
- Hypo-allergenic
- Fragrance-free
- Alcohol-free (contains no drying alcohol)
- Softens and smoothes skin
- Improves skin clarity
- Visibly reduces age spots
- Retinol - #1 dermatologist recommended anti-aging ingredient
Active Ingredients: Ensulizole 1%, octinoxate 6%. Inactive Ingredients: Water, C12-5 alkyl benzoate, cetyl alcohol, glycerin, cetearyl alcohol, triethanolamine, dimethicone, phenoxyethanol, panthenol, retinol, tocopheryl acetate, camellia oleifera leaf extract, BHT, tocopherol, cetearyl glucoside, butylene glycol, polysorabte 20, carbomer, disodoium EDTA, titanium dioxide, polyhydroxystearic acid, silica, alumina, methylparaben, isopropylparaben, isobutylparaben, butylparaben.
Assembled Country
Component Country


text:
Federal Grant Programs
- NSF EPSCoR
- NASA EPSCoR
- Alaska Biomedical Research Infrastructure Network (INBRE)
- Department of Energy EPSCoR
- US Department of Agriculture
Alaska Colleges and Universities
- Alaska Pacific University
- Ilisagvik College
- University of Alaska
- University of Alaska Anchorage
- University of Alaska Fairbanks
- University of Alaska Southeast
Alaska State Government
- State of Alaska
- State Legislature
- Governor's Office
- Alaska Science and Technology Plan (2003)
- Alaska Science and Technology Plan (2014)
Alaska EPSCoR-Affiliated Organizations
- The Resilience and Adaptation Program (UAF)
- The Resilience and Adaptive Management Group (UAA)
- Bonanza Creek Long-Term Ecological Research
- The Geographic Information Network of Alaska
Other Alaska EPSCoR websites
- Statewide data portal
- Southeast Test Case data portal
- Southcentral Test Case data portal
- Northern Test Case data portal
- Facebook page
- Twitter feed
- YouTube page
- Mediasite material
- Issuu page
Other Links
- Grants.gov - federal grant application website.
- Community of Science - a resource for hard-to-find research and funding information.
- The Alliance for Science and Technology Research in America (ASTRA)
- Coalition on the Public Understanding of Science (COPUS)
- The American Association for the Advancement of Science


text:
How to Decorate a Cake
Learn how to decorate a cake using fruit, nuts, candy and more in this video from EVERY DAY WITH RACHAEL RAY magazine, plus learn how to personalize a cake, make fruit flowers and more. From our collection of Step by Step cooking videos.
Hi. I'm Tracey Seaman, the test kitchen director at Every Day with Rachael Ray. I'm gonna show you how to decorate a cake with everyday treats. I have a cake that's frosted with vanilla butter cream and I have fruits and nuts and lots of candies for us to work with. I'm gonna start by-- well first, I wanna tell you that you don't have to worry just about the top of the cake. You can decorate the sides of the cake with lots of things. I have some chopped [unk] here. You wanna make sure that the nuts are finely chopped so that there'll adhere to the icing well. You can also use chocolate Jimmy sprinkles or multi-colored sprinkles and you can use chopped cookies too. Now you wanna hold the cake over the bowl of the nuts and just pick up a handful of nuts in your palm. Put them up against the cake and lightly pat. Now some of them are gonna fall off but we'll clean that up later on. So you can go all the way around and have a nice nutty edge of the cake. Okay. Another thing that we can do is use fruit. I have sliced kiwis and I have strawberries and I'm gonna put those on another section of the cake. Using fresh fruit is a pretty way to simply put a nice edge to a cake. Another fruit in that idea is to make flowers with sliced almonds and raspberries and blueberries. To do this, you're gonna use the berry as the center of the flower because we'll just alternate. We'll put a blueberry and the raspberry. And then you wanna use sliced almonds as the petals of the flower. Now this works better if you're cake is at room temperature and then you could chill it after you get the flowers put on the cake. You can-- you also do these on the side of the cake too. Since we're doing the berries, it's a fun idea if this is for birthday or special celebration for a particular person. You could do a monogram on the top of the cake with the berry. I'm gonna mark with a toothpick [unk] on top of the cake. It comes out nicer if you use-- if you have a guide so the toothpick is a great way to have-- make a guide for yourself. And you can just align the berries along the line. And so that's a really cute, really cute version there. And next I'm gonna work with candies, try to keep your area clean as you work so you don't get foreign crumbs all over your cake. Now for this one, on top of the cake, I'm gonna make a stencil out of coco powder. And my friend Vanessa made me a nice simple stencil which I probably couldn't do if I tried. Gotta lay this on top, just lightly touch it on the cake. Some coco powder or if you have a chocolate cake, you can use confectioner sugar and just lightly tap. Wanna be thorough but not too heavy with the coco dusting. I'm gonna move this out of the way and carefully lift off the stencil. And that looks really sweet. Okay, I'm gonna move this first cake out of the way so we can have fun with the second one. Okay now, we can use-- we have lots of candy here. I like to use two different size candies it makes it look very whimsical. Candy coated, chocolate candies are great, have nonpareils. I have jellied fruit candies but will do believes these and I would just press them in, into the sides. You want the cake to be room temp for the things to stick on the side better. I'm gonna use some big ones and little ones sort of, you know, not to be in a particular pattern. It's more fun if they are all over the place. Okay, I'm gonna try a few nonpareils so you could see what that looks like. These look really great on a chocolate iced cake, the white dots really pop and kids love jellied fruit candies. So again, I'm gonna try the different colors all around. Here we have some really fun ideas for decorating a cake with candy and fresh fruit. I'm Tracey Seaman and thanks for watching.


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Phosphoglycerate Kinase Deficiency
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Phosphoglycerate Kinase Deficiency is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- anemia, hemolytic with PGK deficiency
- erythrocyte phosphoglycerate kinase deficiency
- phosphoglycerokinase
General Discussion
Phosphoglycerate kinase deficiency is an extremely rare inherited metabolic disorder characterized by deficiency of the enzyme phosphoglycerate kinase. This enzyme is essential for the breakdown of glycogen, resulting in the release of energy. Symptoms and findings associated with the disorder may include low levels of circulating red blood cells (hemolytic anemia); varying degrees of intellectual disability; rapidly changing emotions (emotional liability); an impaired ability to communicate through and/or to comprehend speech or writing (aphasia); exercise-induced pain, stiffness, or cramps; enlargement of the spleen (splenomegaly); and/or paralysis of one side of the body (hemiplegia). In most cases, phosphoglycerate kinase deficiency is inherited as an X-linked genetic trait. In such cases, the disorder is fully expressed in males only; however, some females who carry one copy of the disease gene (heterozygotes) may have hemolytic anemia.
Supporting Organizations
CLIMB (Children Living with Inherited Metabolic Diseases)
- Climb Building
- 176 Nantwich Road
- Crewe, CW2 6BG
- United Kingdom
- Tel: 4408452412173
- Fax: 4408452412174
- Email: email@example.com
- Website: http://www.CLIMB.org.uk
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
Muscular Dystrophy Association
- 3300 East Sunrise Drive
- Tucson, AZ 85718-3208
- Tel: (520)529-2000
- Fax: (520)529-5300
- Tel: (800)572-1717
- Email: email@example.com
- Website: http://www.mda.org/
NIH/National Institute of Diabetes, Digestive & Kidney Diseases
- Office of Communications & Public Liaison
- Bldg 31, Rm 9A06
- Bethesda, MD 20892-2560
- Tel: (301)496-3583
- Email: email@example.com
- Website: http://www2.niddk.nih.gov/
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.com
Last Updated: 1/6/1970
Copyright 2015 National Organization for Rare Disorders, Inc.
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.
Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
The RT top-level project at Eclipse was created in 2008 (charter, creation review) as a means of bringing together various runtime related efforts and technologies at Eclipse. RT is designed to foster, promote and house runtime efforts in Eclipse . It is part of a larger EclipseRT Community move to drive Equinox-base technology across a broad range of computing environments and problem domains. These efforts strive towards the common goal of providing a uniform component model across a wide variety of computing environments. The Equinox framework and OSGi form the basis of this infrastructure.
RT projects target "clients" and "servers" across embedded devices, desktops, and enterprise systems, and provide those intermediate software services which enable applications to be more easily and concisely constructed across these environments. This supports and extends the Equinox vision of a consistent programming and component model where developers create application domain code that runs on a variety of platforms.
By providing a consistent symmetric architecture, Eclipse RT technology enables developers to focus on the business problem at hand and still have many system architecture options available at deployment time.
As a top-level project, RT is overseen by a Project Management Committee (PMC). Most of the real work however, is done in sub-projects. The RT Project Charter describes the organization of the project, roles and responsibilities of the participants, and top level development process for the projects.
ECF is a set of frameworks for building communications into applications and services. It provides a lightweight, modular, transport-independent, fully-compliant implementation of the OSGi Remote Services standard.
See the ECF Wiki for examples, tutorials, other documentation, as well as plans for future releases.
To contribute or find out what's going on right now, please join the ecf-dev mailing list.
The Equinox project provides the OSGi-based runtime on which all of Eclipse is based. Equinox also provides the reference implementations of many OSGi specifications.
The Enterprise Modules Project (Gemini) is all about modular implementations of Java EE technology. It provides the ability for users to consume individual modules as needed, without requiring unnecessary additional runtime pieces. Gemini is composed of subprojects, each of which implements a specific modularized technology.
Gyrex - an open, dynamic and extensible platform for OSGi server applications.
The Remote Application Platform (RAP) is a framework for modular business applications that run on a server and can be accessed from different types of clients including web browsers, rich clients, and mobile devices. It provides a powerful, multi-platform widget toolkit that enables developers to write applications entirely in Java and re-use the same code on different platforms. RAP integrates well with proven technologies such as OSGi and JEE.
The Riena project is the foundation for building multi-tier enterprise client/server
applications. As such Riena is broadening the usage of the service oriented architecture of OSGi/Equinox
by providing access to local and remote services in a transparent way. Using this uniform programming
model, the components of Riena and the business components of the enterprise application can be
developed regardless of their target location.
The Riena user interface components will support a business process oriented user interface visualization and navigation metaphor which is alternative to the default RCP workbench layout.
SMILA - Unified Information Access Architecture is an extensible framework for building big data and search solutions to access unstructured information in the enterprise. Besides providing essential infrastructure components and services, SMILA also delivers ready-to-use add-on components, like connectors to most relevant data sources.
• Define and implement an extensible framework based on SOA principles and standards (e.g. BPEL, REST), which is dedicated to the access and integration of (unstructured) information.
• Provide ready-to-use framework components (data source connectors and service implementations) that help to demonstrate and leverage its capabilities.
• Deliver interfaces for management, operation and monitoring of the framework and its components.
The Virgo Web Server from EclipseRT is a completely module-based Java application server that is designed to run enterprise Java applications and Spring-powered applications with a high degree of flexibility and reliability. It offers a simple yet comprehensive platform to develop, deploy, and service enterprise Java applications.
The Virgo kernel supports the core concepts of Virgo and is not biased towards the web server, thus enabling other types of server to be created. The kernel can also be used stand-alone as a rich OSGi application platform. A server runtime can easily be constructed by deploying suitable bundles on top of the kernel.
The major features of Virgo are listed on the Virgo home page
Looking to find out more about RT and runtime technology at eclipse.org? The easiest way is to try it out. See the general EclipseRT Technology Getting Started Guide for how tutorials and webinars on how to work with the runtime technology at eclipse.org.
If you want to get involved, find out more, ask questions, report bugs, get (or contribute :-) code, check out the RT newsgroup or the newsgroups and mailing lists for the various RT projects.


text: Boca Raton Firefighters and Paramedics are helping to keep your children safe by offering the "Child Safety Passenger Program". Specially trained personnel from Boca Raton Fire Rescue Services will install your child safety seat and check your existing seat for proper installation. The free of charge program is offered on the second Saturday of every monthfrom 10a-1p at Fire Station #5, located at 2333 W. Glades Road across from the Town Center Mall. For more information please call 561-982-4000 . Appointments are encouraged, but not necessary.


text:
Warm Arugula Salad with Parmigiano Reggiano
Recipe Summary
Recipe Servings: 6 portions
Recipe Preparation Time: 10 minutes
Recipe Cook Time: 5 minutes
2 tbsp Lucini® Organic Limited Reserve™ Extra Virgin Olive Oil
6 cloves garlic, thinly sliced
1 jar Lucini™ Organic Tuscan Harvest Plum Tomatoes, Diced
1/4 cup Lucini® 10 Year Gran Riserva Balsamico
1 tablespoon chopped fresh basil
Salt and cracked black pepper
2 bunches arugula, washed and spun dry
1/2 cup shaved Parmigiano Reggiano
To prepare the tomatoes, heat the oil in a large sauté pan. Add the garlic and carefully cook until golden brown. Add the tomatoes, vinegar, and basil and simmer gently 5 minutes. Season with salt and black pepper.
To serve, divide the arugula onto 6 salad plates. Top with warm tomatoes and finish with shavings of parmigiano reggiano cheese.
Recipe by:
Chef Caprial Pence is the chef and co-owner of Caprial's Bistro in Portland, Oregon, which opened in 1992. Shortly after graduating from the Culinary Institute of America, Caprial was named Best Chef: Pacific Northwest by the James Beard Foundation, the first female recipient of this prestigious award.


text:
ECS | CeRTS | IWAS | Teachers
| Students | Administrators
| Student Assessment
| IL Learning Standards
| Programs | Forms
| Glossary Skip
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October 10, 2003
Springfield, IL - Carolyn Baider not only teaches
children with special needs, she personifies the word special.
Originally hired as a classroom assistant at Walter R. Sundling
Junior High School in Palatine, Ill., Carolyn demonstrated
a real gift for teaching and, after earning her M.S. in Special
Education, she joined the teaching staff at Sundling. Four
years ago she was diagnosed with terminal cancer, but she
didnt let that stand in the way of teaching. She rarely
missed a day of school even while she was undergoing treatment
and she never complained.
That inner strength and passion for teaching is what made
Baider a recipient of the Milken National Educator Award.
As one of two Illinois honorees, and one of 100 nationwide,
Baider will also receive $25,000 to be used in any manner
she chooses.
The award is given annually to teachers demonstrating exemplary
teaching skills and personal commitment to education. This
year, 100 teachers in 47 states and the District of Columbia
will receive Milken awards. To date, the Milken Family Foundation
has honored almost 2,000 teachers, distributing more than
$47 million.
According to her colleagues, Baider is a natural born leader.
She is praised for her tireless efforts in finding innovative
teaching strategies that help students learn and sharing her
knowledge with the other teachers. Baider is credited with
creating a new referral program for the building and is considered
the local expert in Brain Based learning throughout the district.
She is also very active on committees throughout the district
and frequently conducts workshops to share her expertise and
Baider works closely with parents and community members as
well. Her philosophy is that working together towards improving
learning is vital in helping ensure that all students become
successful learners.
According to one of her colleagues, shes a multi-faceted
leader and uses creative ways to reach people at every level.
Now in remission from cancer, Baider doesnt take the
time to look back. She focuses only on the future and doing
what she loves mostteaching.
The name of the other Milken recipient will remain confidential
until the educator is notified later this month.
Illinois State Board of Education
100 North First Street
Springfield, IL 62777


text:
I never used to think of myself as predictable, but as the years pass, certain traditions I hold dear seem more firmly rooted in my psyche than ever before, and I've surrendered to the possibility that I mark time in ways that make sense… to me. It's a bit daunting that the calendar year seems to fly by these days, but I'm of "a certain age" and as the days grow shorter, I'm reminded that I have more summers behind me than lie ahead. With fall officially here, I'm doing my best to live in the moment and not worry about frigid temperatures and shoveling—there's plenty of time (uh huh) for that down the road. Meanwhile, as the leaves begin to turn, I hear the strains of haunting music that imprinted on my young mind many years ago, in a darkened theater, watching "The Summer of 42" play across the screen.
The theme song, "The Summer Knows," is (IMHO) beautiful, haunting, and captures the end of one season and the beginning of another in such an evocative way, that I download and post it every year on the first day of autumn to share with anyone who cares to listen. The music, written by the incomparable Michel Legrand, moves me deeply and the lyrics, by Marilyn and Alan Bergman, capture the essence of the passage of time. "The summer smiles, the summer knows, and unashamed, she sheds her clothes," drifts through the air as I think about raking, pumpkins and attempting to snap photos that will linger beyond the last leaf fluttering to the lightly frosted blades of grass. Slightly unwilling to let go, I let the words and music wash over me. "The summer smoothes the restless sky, and lovingly she warms the sand on which you lie." I play it over and over these first few days, as I make my way through the Upper Delaware River Valley, camera in hand, as Dharma and I stop to hand apples to our neighbor's horses, while observing the barns fill with hay.
As predicted, we spent two days last week with scores of volunteers, working the phones and soliciting donations on-air for Thunder 102's third annual Country Cares for St. Jude Kids Radiothon. Still in the midst of a difficult economic climate, I was unsure how it would all turn out, but I continued to listen to the song: "The summer knows, the summer's wise, she sees the doubts within your eyes," and let go, hoping for the best. The event (with the help of so many members of the community) was a huge success, and together, we raised more than $38,000 (in 48 hours) to help fight childhood cancer. On behalf of everyone involved, we thank you.
Hearing that Jeff Bank was celebrating its 100th birthday (Dharma has an account), we stopped by to congratulate the staff and wish them well, before heading out to yet another volunteer committee meeting, this time in anticipation of (gasp) making "the magic of Christmas come alive." Santa's Village (www.facebook.com/santasvillageathilltophomes [2]) is "a free annual event open to the community," started by Dave and Corinne Dunlap, when they realized that there was "nowhere in the Monticello area for kids and adults alike to see Santa and enjoy the magic of Christmas." Their mission "to raise funds for Sullivan County CASA" (www.sullivancoutycasa.org [3]) and provide gifts under the tree for kids (www.toysfortots.org [4]) has grown exponentially over the years, and partnering with the M&M Auto Group (www.mmautogroup.com [5]) and Thunder 102 (dot com) has enabled the Dunlaps to see their dreams realized, one toy at a time. "Over the last few years," the Dunlap's shared, "we have collected well over $15,000 and more than 3,000 toys at Santa's Village, while assisting CASA (court appointed special advocates), which provides screened, trained and supervised volunteers, appointed by the court, to speak up for the needs of abused and neglected children,"
Since Santa's Village is a free event, it literally "takes a village" to make the Dunlap's dream (The Hilltop Express, spectacular decorations and a musical show with over 150,000 lights) a reality for the community at large, and so naturally, we solicit donations in an effort to provide holiday memories for those less fortunate. It seems early, but this year promises to be bigger and better than ever before, which requires months of planning and scores of volunteers. Once again, the lyrics nudge me into action. "And so she takes her summertime, tells the moon to wait and the sun to linger, twist the world 'round her summer finger. Let's you see the wonder of it all. And if you learned your lesson well, there's little more for her to tell, one last caress, it's time to dress… for fall."
To contribute to Santa's Village, call Dave Dunlap at 845/807-7555, or email email@example.com [6], or contact me directly at email@example.com [7].


text:
Public Communication (received after Agenda Packet production):
Additional Item for Council Consideration:
CALL TO ORDER PUBLIC OPEN TIMEAPPROVAL OF THE AGENDA ORDER COUNCIL AND STAFF ANNOUNCEMENTS PRESENTATIONS 1. Presentation of a Proclamation Declaring June 19, 2013, as "Mill Valley Comedy Day." CONSENT CALENDAR: 2. Warrants--$1,363,767.72. Recommended Action: Approve paying expenses authorized by the adopted City Budget. 3. Consideration of a Resolution Establishing the 2013/14 Budget for Wastewater Services to the Sewerage Agency of Southern Marin. Recommended Action: Adopt Resolution No. 13-___. 4. Consideration of a Resolution Approving a Professional Services Agreement between the City of Mill Valley and the Mill Valley Chamber of Commerce. Recommended Action: Adopt Resolution No. 13- ___. 5. Authorize City Manager to apply for coverage under the State Water Resources Control Board's Phase II Small Municipal Separate Storm Sewer Systems General Permit Recommended Action: Authorize appropriation. 6. Consideration of a proposal to cancel the July 1, 2013 regular City Council Meeting. Recommended Action: Authorize cancellation. 7. Consideration of a Resolution Authorizing a 2.7% Rate Increase for Refuse Services Pursuant to the Terms of the Franchise Agreement Between the City of Mill Valley and Mill Valley Refuse Services. Recommended Action: Adopt Resolution No. 13-___. 8. Consideration of a Resolution establishing the 2013-2014 Appropriations Limit. Recommended Action: Adopt Resolution No. 13-___. OLD BUSINESS 9. Discussion of Amendments to Certain Portions of Title 20 of the Mill Valley Municipal Code, Zoning Ordinance, Regarding "Floor Area Ratio" and "Residential Second Units." Recommended Action: Discuss and provide direction. COUNCIL LIAISON REPORTS None. CITY MANAGER'S REPORTS None. COUNCIL REQUESTS AND IDEAS FOR DISCUSSION ADJOURNMENT– To the next Regular City Council meeting which will be held on Monday, July 15, 2013.
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text: My sushi obsession has led me to try almost every sushi restaurant in Columbus. Kooma, across Vine from North Market, is the one that keeps me coming back, thanks to its almost overwhelmingly extensive menu and consistently fresh ingredients. Kooma's colorful rolls are likely the best thing you'll ever eat in a parking garage.


text:
There are many opportunities to join the University Program Board (UPB).
Executive Board
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385C Long Reach Excavation
|Operating Weight
|195109.0 lb 88500.0 kg
|More Less
Caterpillar Long Reach Excavation machines are ideally suited for applications such as deep or long distance digging in sand or gravel pits (replacing draglines), slope forming, cleaning of settling banks and ponds, drainage, etc. These excavators can feed directly into a hopper or load a truck
Designed to deliver power and maximum control for long reach excavation jobs. For weed-cutting and tilting buckets, medium pressure circuit, as well as hydraulic lines for the boom and the stick, are available as options.
The Long Reach Excavation booms and sticks are purposely designed, following Caterpillar standards, to provide maximum performance and durability in digging applications with a productive bucket size.
Caterpillar offers a wide variety of buckets for its Long Reach Excavation product range.
The heavy duty and wide undercarriages are stable and durable and provide extra stability over the side.
The Caterpillar exclusive SmartBoom feature eases the operations by smoothening the movements and accelerating return cycle speed.
The heavy-duty upper frame guarantees durability and resistance to handle increased loads and movements generated by the demanding long reach application. A heavier counterweight balances the swing bearing and provides enhanced stability.
Fast, easy service has been designed in with extended service intervals, advanced filtration, convenient filter access and user-friendly electronic diagnostics for increased productivity and reduced maintenance costs.
Your Cat dealer offers a wide range of services that can be set up under a customer support agreement when you purchase your equipment. The dealer will help you choose a plan that can cover everything from machine and attachment selection to replacement.


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Woman denies prescription fraud
BARRE — A Granite City woman is accused of obtaining prescription drugs by forging a letter to a doctor.
Sara J. Tucker, 34, pleaded not guilty Thursday in Washington County criminal court in Barre to three counts of felony prescription fraud and one count of false pretenses.
If convicted, she faces a maximum of six years and three days in prison and a $16,000 fine.
According to the Vermont State Police affidavit, Tucker had been receiving methadone daily from Baart Behavioral Health Services in Berlin since 2011 for opiate addiction.
State police say that in September her prescribing doctor learned she had sent a forged letter from Baart to a doctor at Central Vermont Medical Center saying Baart was no longer giving Tucker methadone and the doctor at CVMC could start prescribing it to her.
The doctor at Baart had also learned that Tucker was being prescribed Valium and Adderall by a nurse practitioner at Family Psychiatry Associates in Barre. The doctor at Baart told state police Tucker had not told her that she was receiving prescription drugs from other providers.
State police say that along with her daily dose of methadone from Baart, Tucker was receiving the drug from another doctor since January 2013 and Valium and Adderall from a nurse practitioner for several months.
State police spoke with Tucker in December and say she admitted writing the forged letter after a friend suggested she should so she could sell the drugs. Tucker told state police her friend told her what to write and Tucker cut and pasted the letter onto Baart letterhead with the signature of a Baart councilor on it.
Tucker told state police she would give the drugs to her friend in exchange for $300 to $400 per month. In September, Tucker told state police she and the friend had a falling out and she suspected the friend made an anonymous call to Tucker's doctor at CVMC telling him about the fraudulent letter.
State police say that after the forgery was discovered, the doctor at CVMC and the nurse practitioner stopped prescribing drugs to Tucker. Police say she is still receiving methadone from Baart but it has been its policy that she take the drug in the presence of staff and not be allowed to leave with it.
Tucker has convictions of unlawful trespass and retail theft in 2013, two counts of false pretenses in 2012, petit larceny in 2011 and two counts of disorderly conduct in 2010.MORE IN This Just InMONTPELIER A new report from a commission that studied the cost, availability and quality of... Full StoryVermont fish hatchery changes focus, looks inland
BETHEL, Vt. Full StoryHONOLULU (AP) A group of Hawaii musicians and a Hawaiian Airlines flight attendant provided... Full Story
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Welcome to the Forum for InventorSpot.com, the most popular invention related website in the world. Read our welcome message.
Moderators: Michelle, Scrupulous, citizen
Good answer, So your going for the education for marketing future products,,,, Good dealAverage Inventor wrote:chic1,
My goal is to get my product to market and build strong relationships and understanding to help launch future projects. I like the concept of the show that it details the entire process of bringing a idea to market and that it works with the inventor to improve and perfect the idea to create a branded product. The royalties they offer are very attractive and the exposure for both your idea and you as an inventor is very alluring.
Jason do you know the percentage EE is offering? Or is it negotiable depending on the product and the notion that there's a great need for this product and is marketable?citizen wrote:I'm there for the same reasons American Inventor is.
I'm there to get my product to market (and sort of validate myself), make some money, and to gain knowledge to get future products to market.
Randy they've been to about 5 city's this year, You my want to look into a audition that's close to Denver where you are. The big Idea is a good show they give you 5 minutes of fame but not sure how many people accurately watch it to receive your fame.Work2XL wrote:I hate threads on EE. I've never seen the show and can't find it here in the Denver market for some reason. Is there anywhere I can find it on the net.
I still think the best show for people looking to take a product to market is Dragon's Den and The Big Idea.
I just wish they would do a version here in the US. Donny is starting to do the elevator pitch segment.
Mrsb how you think you did? Also is you invention something that's a add on the a previous invention or something totally new to the market?Mrsb wrote:If you go to www.everydayedisons.com and download the particpant agreement and the annuity agreement you will see what percentage is offered. Today is 6 weeks and 1 day since the atlanta, ga audition and my sister and I are still hopeful but the wait is really hard.


text:
Click the button below or email email@example.com to contribute your experiences with this product. Although not necessary, it's interesting to have a first name, city, state and country (no email addresses will be used). Any information submitted becomes the property of Tennis Warehouse.
Please include any relevant information such as skill level and style of play.
Comments: These are great shoes, very lightweight comfortable, supportive and stable -- nice colors too. Requires
a little break in for me as I found them a little stiff out of the box. I have wide feet so these fit me well, unlike the Courtballistec
4.3 which I felt didn't fit me well (plus it felt heavier). Comparing this adidas shoe to my other shoe which is the Nike Breathe
Cage, the Nike has better outsole durability and traction and a bit more responsive zoom air cushioning and slightly better
stability but the Adidas CC Feather II is just so light yet comfortable and stable as well.
From: John, 6/13
Comments: I like the weight and look of these shoes, but found them to be very narrow. I wear an 11 1/2 D/E and
bought a 12, and still found them narrow. Comfortable to walk in, but not to play in. Hurt my left ankle going for a volley to my
left, and still feeling it three weeks later. Going to go back to playing my roomier old KSwiss shoes, and use these for walking.
From: Doug, 6/13
Comments: I got these shoes and after 10 minutes of playing I was getting really bad foot aches. I have a pretty
wide feet so that might be the problem. I don't recommend these for wide feet, but for narrow feet, I think they would work fine.
From: Rafa, 6/13
Comments: After less than 3 weeks I already noticed that the sole was wearing out. I can see the yellow through the
black sole near the toe. And there is no warranty. The shoe feels great on the court, but I can't afford to buy new shoes every
From: Thomas, 5/13
Comments: I have really wide feet. Half-size up and these fit perfect. Faster and better support than my previous
New Balance. They really strike a balance between speed, light-weight and support. My other favorite shoe is the Nike Kobe 8,
which is even lighter but my quads feel much better after a long session with these adidas due to their padding and support. Fast
starts and I've never rolled an ankle in them. A+
From: Josh, 4/13
Comments: I have border line narrow medium width feet. The version I wear are narrower, more snug around the
toes and also felt more mobile because of their slimmer profile. Having said that, the newer version II whilst being wider in the toe
box still holds my feet securely. It is a better shoe overall. Softer without requiring a break in, lighter, better lacing system that
secures the foot tightly and is very stable. No ankle rolling. The lacing can dig into the foot if tightened hard. My other gripe is
that even if it is a light weight shoe I'd expect the soles to last longer. After 4 months of playing 5 hours a week on hard courts
the front of the shoes where I pivot are wearing through. All in all this a very good shoe. Other shoes that I have used are Asics
Gel Resolution 4 on clay which has a better fit, but is heavier and Babolat Propulse which had a snug fit but very heavy and
From: Samir, 4/13
Comments: These shoes require some break in time. I noticed the uppers around the ankle are hard and were
causing blisters. To prevent that, I tried to tighten the laces. Hopefully when the shoes break in, they will be more comfortable.
From: Derek, 3/13
Comments: This was a great shoe, but it only lasted for a few months (I play 40-50 hours a week). If it lasted
longer I would buy another pair. I definitely will be playing with lotto's next season.
From: Sam, 3/13
Comments: FYI - this shoe has a lower arch, so I added an insole from an old pair with a higher arch. I really like
these shoes!
From: David, 3/13
Comments: These are the worst tennis shoes I've worn. Just sent them back to Tennis Warehouse because they are
actually painful to wear. I never write reviews and am generally a fan of adidas, but they missed the mark on this one.
From: Matt, 2/13
Comments: I'm a bit of a skeptic when it comes to marketing ploys about sports technology and how much of a
difference it will make. I used a pair of cheap New Balance shoes for about a year that held up strong, and then switched to the
more expensive Babolat Propulse 3's with the hope that they would make some kind of change in my performance. The only
difference was that the soles wore out in about 3 months and they were even heavier and slower than the cheaper shoes. I decided
to take a risk and buy these Adidas CCs, and I really did notice a substantial increase in speed. I can't speak to durability just yet,
but they feel solid and explosive on sprints. My toes are a bit crooked and my arches are flat, so I was eager for a low shoe with a
wide front. These are the most comfortable athletic shoes I have worn and by far the lightest. I'll probably save them for real
matches instead of practice. Highly recommended.
From: Daniel, 2/13
Comments: They are really light but not durable at all. I got mine a week ago and they're
already wearing.
From: Jim, 2/13
Comments: Among the lightest tennis shoe available in the market currently. No break in required. It feels just like
a running shoe instead. Sprinting for down the line or drop shots are definitely easier with these. The Clima cool technology
makes it more breathable. Especially if your living in a hot climate. For the amount of weight they'd put in, traction, stability and
durability are still more than just satisfactory to me. These are definitely a huge upgrade from the first adizero feather. These will
be definitely a future classic. I hope adidas will continue with some other colorways for this specific model.
From: Haq, 2/13
Comments: This shoe was by far the most comfortable shoe I have worn while playing tennis. I have used the
Ace, the Asics Gel Resolution 3 and 4, and still believe these shoes to be far superior in weight, comfort and they don't seem that
they would wear down based on the rigor of play thus far and the lack of any signs of being worn down. I play about 2-4 hours a
and these have been great. Another shoe to add to the list of legendary shoes by Adidas!
From: Yat, 1/13
Comments: My favorite shoe! I have never had a speed shoe before and I sure hope that this one lasts a while.
From: Ryan, 1/13
Comments: Very nice shoes! Love the light weight and support!
From: Anon, 12/12


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Was it a good tourny? i was gonna go watch it just to see how everything works in league paintball but i cudnt i was helping my dads friend move into his new house . Im New to the sport and im only 13 as i have sadi b4 in other topics.....
But was it a good tourny?
The renegade paintball tourny in salina
Started by Card, Oct 01 2008 10:36 PM
2 replies to this topic
Posted 01 October 2008 - 10:36 PM
Woot Bagel!
Posted 03 October 2008 - 02:05 PM
it wasnt to bad but could have been better
i like own all you noobs like hardcore
Posted 03 October 2008 - 05:47 PM
ya i wanted o go watch gues ill just have to watch the youtube vid .... if it ever comes out -.-
Woot Bagel!
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users


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USB Mikes - Any recommendations? Need advice before purchasing
Posted 02 January 2011 - 07:29 PM
Samson Portable USB Go Mike - retails for around $50
Blue Microphone - Snowball USB Microphone - retails for around $99 on sale
Blue Microphone - Snowflake USB Microphone - retails for around $69 on sale
Advice, recommendations, pans? Don't want to spend more than around $150
BTW: It is for a Toshiba Laptop and my operating system is (gawd help me) Windows Vista.
Posted 02 January 2011 - 07:46 PM
However, before you part with any cash, tell us something about what you want to do with it. A USB mic may not be the best way to go in the longer term.
My Facebook Music Page
Posted 02 January 2011 - 08:46 PM
my first set up was a tascam US 122 interface, and a very simple microphone, id highly suggest something similar.
just because an interface is very useful, and will most probably give you phantom power to support better mic's than usb can do, as well as guitar channels and lots more..
my biggest advice it dosnt matter how new the technology is as long as it works.
tascam US 122's are pretty aged now, so if you can get one (or something similar) it should be way within your budget
and while i sold mine on to a close friend so i dont know how its doing, the friend said he still has fun with it when hes got time ..
Posted 02 January 2011 - 11:19 PM
Posted 02 January 2011 - 11:35 PM
That make sense?
Posted 03 January 2011 - 07:18 AM
The specs are similar enough. It can be used in both omni and cardioid patterns and, from the tests I have seen and heard, it does the job well. It's also the cheapest.
It will do the job you want it to do and, should you want to do more later, you won't have wasted money - I suspect you could always find a use for something small and easy to set up, such as this.
You may also find that a mic stand will help and you will need to consider what software to use with it. Try it and see. If you have issues with setting things up, or with latency, post here and we can make some suggestions (it can be confusing at first).
My Facebook Music Page
Posted 03 January 2011 - 09:58 AM
Lyrics website Lyricadia
Lyric of the Year 2007 (Numbers Make the Man), 2011 (The Volunteer) and 2013 (All Pals Together)
Posted 03 January 2011 - 10:46 AM
I'd go with the Samson myself but, only because, I've heard a $100 Samson mic deliver a great sounding track. What was so great about this Samson mic? Absolutely nothing at all. The singer was exceptional. This should tell you something. A $150 USB mic isn't going to be the most exceptional microphone you've ever heard. All three of the mics listed here are probably pretty much the same. Don't expect miricles and you'll be fine. Remember, it's a $150 budget we're speaking about here.
It's never the microphone though. It is what you put in front of the microphone which matters.
---Rupert Neve
ANGELz REIGN Productions
Posted 03 January 2011 - 10:56 AM
Len, on 03 January 2011 - 02:58 PM, said:
I suspect that you are talking about the normal noise from a laptop fan, Len (though they can be very quiet). However, a couple of things are worth mentioning.
First, it can help to move the mic off the table the laptop is on (in case of any vibrations.
Second, some laptops give off a ground loop hum (and other noise). If you get this , try unplugging the laptop and just running it off the battery. It should quiet things down.
My Facebook Music Page
Posted 03 January 2011 - 12:02 PM
Lzi has it right though. I've a $100 mic and a $10 voice and I don't care too much about the hum. We can try to get the most from our budget kit but the best solution is to sing and play louder
Lyrics website Lyricadia
Lyric of the Year 2007 (Numbers Make the Man), 2011 (The Volunteer) and 2013 (All Pals Together)
Posted 03 January 2011 - 03:21 PM
Cheers Lzi, Al, Len, M24, Harreh in no particular order!
Posted 03 January 2011 - 05:01 PM
Sammy Harry, on 03 January 2011 - 09:21 PM, said:
Cheers Lzi, Al, Len, M24, Harreh in no particular order!
Just to be clear, I'm advising you to get a longer usb cable so that you can put some distance and a door between your music and the noisy laptop. Alistair may have a separate point about ground hum (that's noise from the mains power supply) but I'm not advising you get a cable for that. Hope it all works out for you and good luck.
Just remember to increase the mic volume in vista once you've installed the driver. My samson mic volume in vista was set very low on install and it looked like it didn't work.
Lyrics website Lyricadia
Lyric of the Year 2007 (Numbers Make the Man), 2011 (The Volunteer) and 2013 (All Pals Together)
Posted 04 January 2011 - 11:18 AM
Posted 04 January 2011 - 11:45 AM
blu_kola, on 04 January 2011 - 04:18 PM, said:
I'm not sure what "switch options" you are referring to, but I assume it must be the polar pattern. For Sammy's benefit, I should point out the the Samson has exactly the same options (cardioid, cardioid with -10dB pad and omnidirectional).
My Facebook Music Page
Posted 08 January 2011 - 10:36 PM
He said that they don`t keep any of the Samson products in stock ``we only keep in stock the stuff that works``. Ha ha ha...ha ha...eh..h....well then how about not advertising it on your website!!! (eeeejits!).
Sheesh. Anyone have any final remarks before I start looking for used versions of the gear he suggested?
Posted 09 January 2011 - 04:17 AM
Lyrics website Lyricadia
Lyric of the Year 2007 (Numbers Make the Man), 2011 (The Volunteer) and 2013 (All Pals Together)
Posted 09 January 2011 - 06:58 AM
Their job is to upsell (especially when they don't have the item!). Their advice is usually worth what you pay for it (i.e.zero).
Here's a guy using a couple of Go mics for vocal and guitar (and there are others on Youtube) .. http://www.youtube.c...h?v=1GEKRokf3IA
Maybe just order it from Amazon?
My Facebook Music Page
Posted 09 January 2011 - 02:16 PM
Posted 10 January 2011 - 07:27 PM
Cheers folks,
Posted 10 January 2011 - 08:25 PM
What you are experiencing is latency. You will be best with an ASIO driver for your soundcard. Download ASIO4ALL (it should work with your soundcard) and see if you can use that.
Don't buy expensive software. For simple recording, you could use Audacity (free) or Reaper (cheap for non-professionals).
I think you might have been better with the Go Mic, but what you have will work, I'm sure.
If you can't hear the latency when you are recording, it may just be a question of setting up Jamstudios to compensate properly. Sorry, but I don't know how JamStudios operates (maybe Kimberly can help?). OTher software has ways of setting up the compensation automatically.
My Facebook Music Page
Posted 22 April 2011 - 07:12 PM
Sammy Harry, on 08 January 2011 - 11:36 PM, said:
He said that they don`t keep any of the Samson products in stock ``we only keep in stock the stuff that works``. Ha ha ha...ha ha...eh..h....well then how about not advertising it on your website!!! (eeeejits!).
Sheesh. Anyone have any final remarks before I start looking for used versions of the gear he suggested?
This guy you've been dealing with is the hack! Ask him if he has ever recorded a vocal? I wonder how many podcasts he's done!? $7000 huh? If you want to get professional level sound in your home, not pretend "professional" then, in reality you're looking at a minimal investment (gear only, does not include room treatment) of $25,000...$7,000 won't get you even close to "professional quality." And, no, Behringer isn't going to cut much mustard. Though, you will no doubt find, there is a virtual troop of Behringer users who swear by the crap (I wouldn't bet good money on any of their ears being very prescise)...Want "Professional?" Think Pro Tools HD, Logic, Nuendo. All that said however, at the end of the day it's going to come down to who is running the gear, and how good their ears are. You can make "Pro" quality recordings on lesser gear, the deciding factors being, Time spent, Patience, and most importantly, Care. Without reliable hearing however, you've lost before you begin. No gear in any studio is more important than the engineer's ears.
Welcome to the world of retail music store non-salespeople. Like Alstair already said, their entire game is to upsell, upsell, upsell. These "salespeople" don't know their rear-ends from a hole in the ground. For $100 the best mic in the entire world is a Shure SM 57 Dynamic. It won't sound "bad" on much of anything, and I know it sounds better than a $100 condensor anyday of the week. It's built like a tank, you can use it to drive nails (I have). Don't try this with a Samson mic though unless of course, you'd like to have a good cry!
Tell your "favorite" salesman, Lz said to go buy some ears. LOL
---Rupert Neve
ANGELz REIGN Productions
Posted 22 April 2011 - 10:42 PM
I like Long and McQuade, and the one I go to I've been to enough times and talked with enough of the staff to know who to ask about what. When I first started recording I went in to buy a Boss BR1600 that was on sale and the guy desperately tried to convince me that the Yamaha and Tascam recorders were much, much better. He went on a tangent about Roland and their customer service (have so far never had to deal with them)
Just do you your research and stick to your guns. L&M is a decent enough store and has some great musicians working there who are more than happy to talk shop (not commission based)
Always up for a collaboration with lyricists!
Posted 26 April 2011 - 10:59 AM
Think, if "getting the best gear into the hands of the customers" was truly the primary goal of any chain music store, why are there thousand's upon thousands of musicician's out there who actually believe that the paltry $2000 they've spent on their home studio actually delivers the world-class sound that the 17 year old snot nose kid sales rep so emphatically preaches about? Look at the thousands of reviews on Harmony Central or Gearslutz. 99% of these reviews are written by people who know absolutely nothing about the gear they are reviewing. You see, in order to make valid judgements on equipment YOU ACTUALLY HAVE TO USE SOME GEAR NOT SIMPLY READ ABOUT IT! How much would someone who has only read about say, a UA LA2A or maybe used a crappy plug-in version, really know about how an LA2A operates/sounds? Do you really trust that wet-behind-the-ears kid sales rep? Do you trust in his vast knowledge of audio gear? You'd do much better to come buy my bridge in Brooklyn! If you are talking to a chain music store sales rep, you are talking to a walking, breathing Guitar Player Magazine ad, and not too much more. Yeah, I know, the sale's people are friendly right? HAHAHA Don't be fooled by a little "feel good, sunshine talk." Don't be the "average customer." Go to a REAL shop to buy your recording gear, or you deserve all of the Toy's R Us crap you get at these Music Mart Department stores. Recording IS NOT a skill for the masses, it's just not. You may choose to belive in fairytales though if you so choose.
---Rupert Neve
ANGELz REIGN Productions


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You Are Here: Home » News From NINDS » Proceedings »
June 27 - 28, 2002
New Orleans, Louisiana
This conference was funded by the National Institute of Neurologic Disorders and Stroke (NINDS), the Office of Rare Disorders, and the Joubert Syndrome Foundation. It took place on June 27-28, 2000 in New Orleans, and was a follow-up to a 1998 symposium on this disorder. Bernard L. Maria, M.D., M.B.A., chairperson, and Robert Finkelstein, Ph.D., Program Director, Neurogenetics Cluster, NINDS, outlined three goals for the conference. The first goal was to provide an overview of current knowledge during three sessions: clinical approaches to diagnosis and management, genetics of brain development and behavior, and Autism and Joubert syndrome. The second goal was to introduce established researchers from backgrounds in genetics, brain development, and behavior to the disorder. Finally, family representatives and research panelists were to engage in discussion culminating in the definition of future research goals.
Joubert syndrome is a rare autosomal recessive disorder caused by a set of cerebellar and brainstem abnormalities, termed the .molar tooth sign. due to their radiologic appearance. Other clinical features commonly include hypotonia, ataxia, and developmental delay. Additional symptoms may include breathing abnormalities (apnea and hyperpnea), problems with eyesight (retinal dystrophy) and visual tracking (ocular-motor apraxia ), kidney problems (renal cystic disease), and a variety of other associated difficulties.
The meeting began with welcoming messages from leaders of the sponsoring NIH Institutes:
Bernard L. Maria, M.D., M.B.A
Eugen Boltshauser, M.D.
William B. Dobyns, M.D.
Bernard L. Maria, M.D., M.B.A. provided an overview of the past 30 years of research on Joubert Syndrome. In 1969, Dr. Marie Joubert first identified the disorder in four siblings in a French-Canadian Family. Although all four siblings shared core characteristics of the syndrome, variability in symptom severity and presentation was remarkable across the children. In 1984, Dr. Maria diagnosed a child with the disorder in the United States and the child.s mother founded the Joubert Syndrome Foundation in 1992.
With the help of the foundation, Dr. Maria assembled a team of researchers to investigate the clinical features of the disorder. The team first described neuro-ophthalmological characteristics, including ocular motor apraxia and difficulties with ocular pursuit (hypometric saccades, impaired smooth pursuit, vestibular-ocular reflex cancellation deficits) and linked these characteristics to cerebellar and brain-stem functioning. Second, researchers described the developmental and behavioral characteristics of the syndrome. Third, Dr. Maria coined the term .Molar Tooth Sign. to describe four essential features: deep interpeduncular fossa, thick and straight superior cerebellar peduncles, and vermis hypoplasia. In addition, abnormalities were identified in the areas beginning at the caudal midbrain and extending to the to rostral medulla. Furthermore, autopsy results suggested that the cerebellar peduncles were uncrossed, leading to speculation that Joubert syndrome was a .non-decussation of major tracts..
The 1998 CNS symposium sponsored by NINDS, ORD, and the Joubert Syndrome Foundation resulted in the first general description of facial and oral-motor characteristics for persons with Joubert syndrome (e.g., prominent forehead, rounded eyebrows, upturned nares, triangular lips, inability to move tongue laterally, etc.). However, it remains unclear whether features are related to hypotonia. Furthermore, diagnostic criteria were revised.
Since 1998, researchers further described the relationships between brain structure and clinical characteristics (e.g., breathing and tongue abnormalities linked to the medulla). However, the relationship between neurobehavior/developmental delay and the hindbrain has not yet been defined. The development of a severity rating scale for brain structure abnormalities on imaging and a quantitative analysis of brainstem structures proved helpful in differentiating Joubert and Dandy-Walker syndromes. In the area of genetics, several candidate genes have been ruled out. Future directions in research on Joubert Syndrome were introduced.
Eugene Boltshauser, M.D. reviewed challenges in the diagnosis of Joubert syndrome, which lead to occasional false positive diagnoses in the literature. First, a variety of characteristics are associated with cardinal symptoms of Joubert in the literature, including short stature, scoliosis, congenital cataracts, hydrocephalus, corpus callosum agenesis, hepatic fibrosis, and sinus inversus. However, reports are inconsistent and the relationship of these symptoms to Joubert is unclear. Second, siblings with Joubert may vary widely in breathing patterns, neuroimaging features, presence of occipital encephalocele, presence of hexadactyly, and length of survival, as observed in the original probands described by Marie Joubert. Third, the difficulty in making a clinical diagnosis is increased by descriptions of syndromes with very similar and overlapping features.
Dr. Boltshauser discussed three features that may be associated with Joubert syndrome: retinal, liver, and kidney dysfunction. Among children with Joubert, retinal dystrophy is quite common and exists along a continuum, from no impairment to marked impairment. Information regarding the long-term prognosis for vision is not available. Dr. Boltshauser also described a subgroup of young children with core symptoms of Joubert syndrome and congenital amaurosis (congenital blindness despite an intact retina). Among these children, no significant visual improvement was observed and varying degrees of kidney involvement were described. Dr. Boltshauser suggested that these children might demonstrate either a subtype of Joubert syndrome or a completely separate syndrome, such as Senior-Loken syndrome.
The presence of liver fibrosis has been discussed in some single case reports, but no systematic study is available. In cases where liver fibrosis is present, liver function is not impaired and is not associated with kidney dysfunction. Liver fibrosis in conjunction with core symptoms of Joubert syndrome may constitute either a subgroup of Joubert syndrome or a separate, overlapping condition (e.g., COACH, Arima).
Finally, Dr. Boltshauser described nephronophthisis, an autosomal recessive condition leading to end stage kidney failure, in children with Joubert syndrome. Description of nephronophtisis in this population is complicated by difficulties in diagnosis of the kidney disorder. In addition, Senior-Loken syndrome is an overlapping condition, which includes characteristics of Joubert as well as kidney involvement and is linked to genes associated with nephronophthisis. Despite difficulties in studying nephronophthisis among children with Joubert syndrome, existing information suggests that nephronophthisis in this population is typically juvenile in onset, with end stage renal failure occurring rarely. Among those children who reach renal failure, the course of nephronophthisis is variable, as is the association between renal and retinal function. Longitudinal study is necessary to understand the relationship between Joubert syndrome and retinal, liver, and kidney functioning.
William B. Dobyns, M.D. reviewed syndromes overlapping with Joubert, noting that the .molar tooth sign. may be related to a variety of hindbrain/midbrain syndromes, as malformations are rarely associated with a single syndrome. A potential set of hindbrain/midbrain syndromes was discussed. First, the distinction between Dandy-Walker syndrome and Joubert syndrome using MRI was described. Second, Dr. Dobyns described .true. Joubert as the molar tooth sign, ataxia, hypotonia, apnea/hyperpnea, and developmental delay without kidney or retinal involvement. Pre-axial polydactyly may also be observed. In cases where congenital blindness is observed, the term .Joubert Lemer Amaurosis. is suggested. Third, Dekiban-Arima syndrome is described as a potentially separate syndrome involving core characteristics of Joubert syndrome in combination with visual problems and cystic dysplastic kidneys. Cystic dysplastic kidneys are described as distinguishable from nephronopthisis, which is apparent in Senior-Loken syndrome. The occasional incidence of polymicrogyria is reported, as well. Fourth, Dr. Dobyns described COACH syndrome as a diagnosis that is in question. Core symptoms include cerebellar vermis hypoplasia, oligophrenia, ataxia, coloboma, and hepatic fibrosis. Next, Dr. Dobyns described Malta syndrome as a possible variant of Joubert syndrome or as a separate syndrome that includes the molar tooth sign, cerebral abnormalities (occipital cephalocele, hydrocephalus), colobomas in both eyes, visual problems, and normal kidneys and liver. Another variant includes characteristics of Joubert syndrome in combination with polymicrogyri, normal kidneys, liver, and retinal function. Seventh, Senior-Loken syndrome consists of retinal dystrophy, possible juvenile nephronophthisis and facial dysmorphology, skeletal anomalies, and early lethality. Finally, a new syndrome (Varadi) involving hypoplastic vermis, molar tooth sign, hyperpnea/apnea, a small cleft in the lip, multiple alveolar phrenula, multiple tongue hamartomas, midaxial polydactyly on the hands and preaxial polydactaly on the feet, and hypothalamic hamartoma is provided as an example of a syndrome which is clearly different from Joubert despite the appearance of the molar tooth.
Dr. Dobyns summarized by noting that multiple problems are inherent to the definition of Joubert syndrome and the location of a genetic cause for the disorder, including the presence of phenotypic variability and probability of the involvement of multiple genes. Some observed features are not very specific (e.g., cephalocele, coloboma) while others are more useful in differentiating between syndromes (e.g., congenital amaurosis, nephronophthisis, cystic dysplastic kidneys, and post-axial vs. mid-axial polydactyly). He suggests the presence of at least five distinct syndromes involving midbrain/hindbrain malformations similar to those seen in Joubert.
Anthony Winshaw-Boris, M.D., Ph.D.
Phillip F. Chance, M.D. and Melissa A. Parisi, M.D., Ph.D.
Thomas H. Wassink, M.D.
In order to enhance understanding of cerebellar development and the genetics related to midbrain and hindbrain development, Anthony Winshaw-Boris, M.D., Ph.D. reviewed studies involving mice. Cerebellar development occurs in a series of steps, including the specification of the cerebellar primordial layer, granule cell generation and migration from the rhombic lip, purkinje cell generation, maintenance, migration from the ventricular zone, and neuronal survival. Each of these stages is directed by specific genes and proteins, many of which may be candidate genes for Joubert syndrome. All types of genes and proteins may be involved, including transcription factors, signal molecules etc.
The brain divides into general regions early in development. The isthmus organizer is a region that plays an important role in the further development of midbrain, hindbrain, and cerebellum and the genes and proteins directing the isthmus organizer may be related to Joubert syndrome. For example, gbx2, obx2, and fgf8 work together to determine where the isthmus organizer will be located. Removal of any one of these genes in knockout studies causes the isthmus organizer to shift in location.
As regions of the brain become increasingly differentiated over time, the rhombic lip, located at the midbrain/hindbrain junction, generates most of the cells that will form the cerebellum. Granule cells proliferate and migrate laterally from rhombic lip to create the cerebellar hemispheres. The cells merge at the midline, where the vermis is formed. After birth of the mouse, cells continue to migrate inward from the external granule cell layer to the internal granule cell layer. Although granule and purkinje cell generation and migration occur in different areas of the brain, several basic processes may be common to both types of cells. Molecules controlling general migration patterns may be important, as well as molecules controlling patterns specific to cerebellar development. The genetic control of migration of neurons past purkinje cell layers (e.g., Lis1), decussation (e.g., dccmetrin pathway), and of neuronal survival may be important in Joubert syndrome.
Melissa A. Parisi, M.D., Ph.D. presented an overview of research knowledge regarding the genetics of Joubert syndrome. First, she reviewed basic information regarding the clinical characteristics of the disorder and its transmission. Joubert syndrome is known to be an autosomal recessive disorder, where unaffected parents pass on genes resulting in Joubert syndrome. The initial French-Canadian probands may have represented a founder effect, where genetic drift resulted in changed copy of a gene, which was passed down on both sides of the family. The prevalence rate of the disorder is one in 100,000, as estimated using consanguineous families, and distribution occurs worldwide. Although prevalence rates were originally described as higher for males than females, current estimates suggest more equal gender distribution.Second, Dr. Parisi reviewed findings in Joubert syndrome using traditional genetics approaches. A genome wide study of ten families using standard linkage analysis (LOD score method) which estimates the linkage between genetic markers, such that a parent's characteristic should be more common among children than a non-parent's characteristic, did not result in a gene loci. This may have been due to widely spaced markers, indicating that children from different families may not have all had Joubert syndrome, but displayed similar, overlapping syndromes. Another method involves identifying identical genetic regions within affected individuals in consanguineous families (identity by descent mapping; IBD). Review of a consanguineous Arab family with symptoms of Joubert syndrome suggested a gene locus on chromosome 9, with two families linked to 9q34.3 by homozygosity mapping. However, two of the four Arab families didn't map onto the gene, suggesting this was not the cause for all families. Examination of 26 families with children with Joubert syndrome and did not implicate 9q34.3. However, other conditions in which cerebellar hypoplasia is a characteristic map onto this gene, suggesting there be a clustering of genes in this region. Chromosomal rearrangement in children with the disease using positional cloning at breakpoints is another frequently used approach. Although a patient with Smith-Magenis syndrome and features of Joubert showed a chromosome deletion 17p11.2, examination of 26 families did not implicate the involvement of 17p. A gene within this area may be important or a gene on the other chromosome that shows up because of this deletion. Finally, analysis of candidate genes and mutation studies can be useful. As reported earlier in the conference, studies of mice have identified genes related to patterning, signaling, and/or neuronal adhesion at the rhombic lip. Using screening techniques (e.g., heteroduplex analysis, sequencing for mutations, dideoxy fingerprinting, and dHPLC), the following genes have been ruled out: WNT1, FGF8, EN1, EN2, and Bar HL1. Dr. Parisi reviewed challenges to using standard genetics approaches in Joubert syndrome, including the difficulty in making a clear clinical diagnosis (e.g., possible subtypes and overlapping syndromes), the probability of genetic heterogeneity involving multiple loci and multiple genes, the relative lack of families with more than two affected children, and heterogeneity of the presentation of the disease within families. In the future, strategies including testing mutation in candidate genes among existing families, performing a genome-wide screen, and looking in fetal brain samples may be helpful. However, adequate power must be obtained by collecting information from sufficient numbers of families (from 62 to 270 families, depending on the number of genes involved). In addition, advanced imaging techniques and more informative markers with higher resolution may improve research findings. Thomas H. Wassink, M.D. discussed the diagnosis of autism, the types of investigations which have been conducted in the area of genetics and autism, related research findings, challenges in this research, and strategies for meeting these challenges. First, he reviewed the diagnostic criteria for Autism, a developmental disorder characterized by deficits in communication, reciprocal social interaction, and stereotyped and repetitive behaviors and interests. Social difficulties can include impaired non-verbal communication (e.g., eye to eye gaze), lack of social or emotional reciprocity, decreased sharing of interests (e.g., joint attention), and problems with peer relationships. In the domain of communication, children with autism may show delays in language development, stereotyped use of language (e.g., echolalia), and difficulty initiating and sustaining conversation. Finally, difficulties with repetitive behavior can include intense preoccupations, rigid adherence to routines and rituals, and stereotyped motor mannerisms. The prevalence rate of the disorder ranges from 1-2 in every 1000 children and is more common among boys than among girls. The disorder is developmental in nature, and in 10% of cases can be attributed to a definable genetic cause.Heritability estimates are higher than .9, with siblings of a child with autism 50-100 times more likely to inherit the disease than someone in the general population. As in Joubert syndrome, the pattern of heritability is complex. In Autism, anywhere from three to more than fifteen genes may be involved. In addition, epigenetic factors, or non-genetic factors that mediate the effect of the genes on phenotype expression, may be operating.
Seven genome wide screens (look across all chromosomes to try to find regions of the chromosome which might have relevant genes) involving families with two or more affected children have been conducted and the following regions identified as of interest: 7q, 2q, and 13q. Study of 7q suggests an association with autism (LOD 1-3.2). 7q has also been related to specific language impairment (SLI; disorder of language in the absence of other associated features) and a small number of cases of autism have been identified with chromosomal malformations in this region. WNT2, in a 7q linked region, may be implicated in autism. In addition, chromosome 15q11-13 is implicated in Prader-Willi and Angelman syndromes.
Similar to Joubert syndrome, problems with genetic complexity make the search difficult. Approaches to furthering this line of research include narrowing the phenotype by identifying subtypes (e.g., use specific characteristics of autism such as severity of language impairment, IQ, stereotypic/rigid behaviors) or broadening the phenotype by looking at traits present among first-degree relatives. In addition, strategies include looking at related disorders with known genetic causes (e.g., tuberous sclerosis) and using technological approaches to molecular study (e.g., DNA pooling, etc.).
Judith H. Miles, M.D., Ph.D.
Eileen B. Fennell, Ph.D.
Dr. Judith Miles, University of Missouri-Columbia, discussed issues regarding heterogeneity in autism. First, she described the challenge to genetics studies due to variable expression of symptoms, potentially overly broad diagnostic criteria, and the presence of several genetically discrete disorders related to the autism phenotype (e.g., Fragile X syndrome, Tuberous Sclerosis, and chromosome disorders).
In the past, researchers attempted to create subgroups to reduce heterogeneity in this population. Although the most common approach is to form subgroups on the basis of behavioral characteristics, Dr. Miles suggests a different approach, separating children who experienced central nervous system insult during embryogenesis from those who did not. In a study of 465 consecutive referrals to an outpatient clinic, features related to CNS insult (dysmorphic facial features and microcephaly) were examined among children with autism. First, children with dysmorphic facial features exhibited increased rates of microcephaly, seizure, brain abnormalities, and intelligence quotients (IQ.s) of less than 55 than children without such features. Furthermore, children with dysmorphic features demonstrated a more equivalent male to female ratio and less recurrence among siblings than did children who were not dysmorphic. Similar findings were present when children with microcephaly were compared to children without microcephaly.
These findings suggested that among children with autism, children with CNS insult during embryogenesis differed from those without CNS insult. Thus, Dr. Miles and colleagues divided children with autism into two subgroups. The first group contained children with .complex autism. (30% of the total group), defined as autism in combination with dysmorphology, brain abnormalities, or microcephaly. In contrast, children with .essential autism. were defined as those without dysmorphology, brain abnormalities, or microcephaly. Comparison of the subgroups suggested higher IQ.s, fewer seizures and abnormal EEG.s, a regressive pattern of onset, higher prevalence for males than females, and higher family recurrence risk for children with essential autism. In contrast, children with complex autism had lower IQ.s, more seizures and abnormal EEG.s, a gradual onset, a more even gender distribution, poorer outcome, and a lower familial recurrence risk. This method of reducing heterogeneity in children diagnosed with autism is useful to researchers and clinicians because it is based on a sound developmental premise and identifies those children who are likely to have a poorer outcome and lower familial recurrence rates. In addition, all genetic syndromes known to contribute to autism are included in this group. Thus, costly and invasive testing may be limited to children who are microcephalic and/or dysmorphic.
In addition to distinguishing complex from essential autism, gender, macrocephaly, and family history of autism related syndromes might provide useful distinctions. Comparison of males and females with autism reveals similar intellectual functioning, despite somewhat different distribution of scores. Girls are more likely to exhibit features of complex autism (44%) than boys (25%). However, females are, in general, less severely affected (e.g., higher IQ.s, more pretend play, less repetitive behavior). Twenty three percent of children with autism exhibit macrocephaly. In 44% of the children, macrocephaly is familial, suggesting that macrocephaly may be a marker for a common autism gene. Finally, family history studies of autism suggest increased risk for autism, alcoholism, depression, cognitive disorders, language disorders, and ADHD in families of children with autism. In families where history of alcoholism is significant, there is a higher rate of macrocephaly and of regressive autism. More specifically, regressive autism is more frequent among children whose mothers are alcoholic. Thus, alcoholism may be a marker for another common autism gene. Dr. Eileen Fennell, Florida State University, discussed prior studies of behavior and cognition in children with Joubert. Initial study indicated that out of 20 studied children, six were tested and had difficulty with information (60%), picture completion (40%), digits forward (20%), digits backwards (67%), and immediate and delayed recall of stories (75%). Children had difficulties with finger, toe, and heal-toe movements and with visual motor integration due to problems with motor output. Verbal fluency was also a problem. Caregivers described their children as clumsy, demanding, having visual and speech problems, overactive, cries, growth problems, dependent, clingy, problems with eating, and aggressions. In 1998, 32 caregivers rated their children on a developmental inventory. Over half of the children scored below their chronological age with no children scoring in the normal range. When children were classified by severity on MRI, 1/3 of children had problems above the brainstem, including abnormal mylination. However, no relationship was found between behavioral and neuroanatomical data. Future research includes full neuropsychological and behavioral assessment that can be related to MRI.s looking for subtypes among children with Joubert syndrome.
During a morning session of the conference, researchers and family representatives convened to discuss future research directions. The following suggestions were offered:
In addition, the panel generated a series of recommendations for translation of research for the community in hopes of reducing the burden for families through improved community response and support. The following vehicles for communication were suggested:
June 27-28 2002
New Orleans, Louisiana
6:30 AM - 8:00 AM - Buffet Breakfast (Hotel Restaurant)
Welcome and Statement of Workshop Goals
Bob Finkelstein and Bernard Maria
Current Approaches to Diagnosis and Management
Clinical Manifestations and Management
Eugen Boltshauser and Bernard Maria
Overlapping Conditions and Mimicry
Bill Dobyns
Panel Discussion and Question and Answer Session
Break 10:00 AM - 10:30 AM
Genetics of Brain Development and Behavior
Genetics of hindbrain and midbrain development
Tony Wynshaw-Boris
Genetics of Joubert syndrome
Phil Chance
Genetics of Autism
Tom Wassink
Panel Discussion and Question and Answer Session
Lunch 12:00 PM - 1:00 PM (on your own)
Autism and Joubert Syndrome
Heterogeneity in Autism
Judith Miles
Behavior in Joubert Syndrome
Eileen Fennell
Break 2:45 PM - 3:15 PM
Panel Discussion and Synopsis
Moderator: Bob Finkelstein
Closing Comments: Bernard Maria
6:00 PM -7:00 PM Dinner and Awards (Southshore Room)
7:30 AM - 9:30 AM (Continental Breakfast will be available)
Recommendations for Future Research Directions
Moderators: Bob Finkelstein and Bernard Maria
Michelle Abdulaziz
Vice President
Joubert Syndrome Foundation
Karen Barnett, M.S.
Genetic Counselor
Department of Pediatrics
University of Washington
Craig Bennett, Ph.D.
Senior Research Fellow
Division of Genetics and Development
School of Medicine
University of Washington
Eugen Boltshauser, M.D.
Department of Pediatric Neurology
Children's Hospital
Barbara Braddock, M.S.
Developmental Psychology
Department of Psychology
University of Missouri - Columbia
Stephen Braddock, M.D.
Associate Professor of Child Health
Division of Medical Genetics
Department of Child Health
University of Missouri - Columbia
Phillip Chance, M.D.
Professor and Chief
Division of Genetics and Development
University of Washington
William Dobyns, M.D.
Department of Human Genetics
The University of Chicago
Cheryl Duquette
Joubert Syndrome Foundation
Janet Farmer, Ph.D.
Associate Professor
Department of Health Psychology
Department of Child Health
University of Missouri
Health Sciences Center
Eileen B. Fennell, Ph.D.
Professor of Clinical and Health Psychology and Neurology
University of Florida
Robert Finkelstein, Ph.D.
Program Director
Neurogenetics Cluster
National Institutes of Health
National Institute of Neurological Disorders and Stroke
Jill Gitten, Ph.D.
Pediatric Neuropsychology Fellow
Department of Psychiatry
Brown University
Ian Glass, MB,Ch.B, M.D.
Associate Professor
University of Washington
Pediatrics and Medicine
Joe Gleeson, M.D.
Assistant Professor
Division of Pediatric Neurology
Department of Neurosciences
University of California, San Diego
Kimberly Henley, B.S.
Medical Student - Research Assistant
Department of Child Health
University of Missouri Health Care
Ellen Horwitz, Ph.D.
Assistant Professor
Child Development and Neurology
University of Missouri
School of Medicine
Benson Hsu, A.B.
Department of Child Health
University of Missouri
Adam Jackson, B.S., B.A.
Medical Student
Department of Child Health
University of Missouri
Danny Liu, B.S.
Research Specialist
Department of Child Health
University of Missouri
Bernard Maria, M.D, MBA
Professor and Chairman
Department of Child Health
Universityof Missouri - Columbia
Kathleen McCann, Ph.D.
Post-Doctoral Fellow
Department of Health Psychology
University of Missouri - Columbia
Judith Miles, M.D., Ph.D.
Professor and Director
Division of Medical Genetics
University of Missouri Hospitals and Clinics
Melissa Parisi, M.D., Ph.D.
Acting Instructor
Department of Pediatics
Children's Hospital and Regional Medical Center, CH-25
Division of Genetics and Development
Sussan Paydar, Ph.D.
Program Analyst
Neurogenetics Cluster
National Institutes of Health
National Institute of Neurological Disorders and Stroke
Nicole Takahashi, B.S.
Research Specialist
Division of Medical Genetics
University of Missouri
Columbia Hospital
Thomas Wassink, M.D.
Assistant Professor
Carver College of Medicine
Univeristy of Iowa
Anthony Wynshaw-Boris, M.D. Ph.D.
Associate Professor
Department of Pediatrics and Medicine
University of California
Last Modified April 8, 2011


text:
Chandler undoubtedly is our key to the Championship, he's made everyone better on D except STAT and brings "it" every night
February 18, 2012, 12:10 pm
Keeping Score: Chandler Overshadowed as Spotlight Follows Lin
[Only registered and activated users can see links. ]
By JUSTIN KUBATKO
With seemingly the entire nation ensnared by the grasp of Linsanity, the Knicks most valuable newcomer, Tyson Chandler, goes quietly about his work as one of the most effective players in the N.B.A.
Acquired by the Knicks in December as part of a three-team trade with Dallas and the Washington Wizards, Chandler was a key member of the Mavericks 2010-11 championship run. A pending free agent, he became available because Dallas was apparently unwilling to give him more than a two-year contract.
Chandler, who finished third last season in the voting for the defensive player of the year, has been the linchpin of the Knicks defensive revival. Last season the Knicks allowed 110.1 points per 100 possessions, which was eighth worst in the league. But this season they are allowing just 99.5 points per 100 possessions, the leagues sixth-best mark.
Although Chandler does not have a signature defensive skill (à la Dennis Rodman or Dikembe Mutombo), his defensive statistics are solid across the board.
Chandler grabs about 22.6 percent of all available defensive rebounds, the best rate on the Knicks, and he leads the team with an average of 3.1 blocked shots per 100 opponent shots from 2-point range.
In addition, Chandler is one of only 11 players averaging at least one steal and one block per game. And even though he is active on defense, he has the eighth-lowest personal-foul rate among qualifying centers, averaging 4.6 fouls per 48 minutes.
While Chandler is clearly the teams defensive leader, he does not play a large role on the offensive end. That said, he takes full advantage of the opportunities he is given, and by some measures he is the N.B.A.s most efficient offensive player.
True shooting percentage is a measure of shooting efficiency that takes into account 2-point field goals, 3-point field goals and free throws. Chandlers true shooting percentage is .736,.064 better than that of the runner-up, Mario Chalmers, and he is on pace to break Artis Gilmores single-season record of .702 set during the 1981-82 season.
Putting it all together, Chandler is one of the more valuable players in the N.B.A.
Win Shares is an estimate of the number of wins contributed by a player through his offense and his defense. Chandler has 5.4 Win Shares in 2011-12, good for third in the league, and he is averaging .247 Win Shares per 48 minutes, the leagues fifth-best rate.
Perhaps most impressive, Chandler is playing more efficiently than he did last season, even though his playing time has increased by almost six minutes per game.
The story of Jeremy Lin is a compelling one, but the contributions of Chandler should not be lost in the hype. Without Chandler, the Knicks might be competing for a berth in the lottery as opposed to a spot in the Eastern Conference playoffs.
Ty Chan. What a legend! Worth the contract without a doubt.
Warrior, winner, womanizer!
Chandler undoubtedly is our key to the Championship, he's made everyone better on D except STAT and brings "it" every night
5 Star Thread
Chandler deserves more respect, Im still heated over him not being selected to the all star team. Defensively hes like Camby and Kurt Thomas rolled into one, we haven't had a center like him for almost a decade. Keep Ballin Tyson and Stay Healthy
Chandler should be the front runner for defensive player of the year imo especially because Dwight is having a sub par year for his usual standards.
Chandler - Defensive Player Of The Year
Lin - MVP
I haven't seen a lot of Howard, so don't know if Chandler has been better than Howard at defense this season, however, he changed the Knicks' defense around big time.
Sig made by Sons of Thunder
And to think, some were mad we gave up Billups for him
Last edited by NY17KNICKS; Feb 19, 2012 at 22:09.
What a disaster it would have been for the Knicks had they allowed Billups to remain on their roster.
Humility is a virtue and pride is a vice.
I think Tyson is my favorite Knick this season.
The intensity he brings to every game and the unselfishness. Just a stand up guy.


text:
March 8, 2012 —
After visiting a friend at the hospital in Port Jervis during late February, I saw that it was turning into a fairly decent day outside; the weather was partly cloudy and the temperature was climbing into the high 40s. It was a good afternoon to drive up Route 97 and scout the river. I was mainly looking for eagles and other raptors. The first flying critters I spotted, however, were not birds at all, but a mass of flying insects. I had encountered one of the first fly hatches of the season on the river; the emergence of the black stonefly.
The black stonefly (Taeniopteryx nivalis) is one species of about a half dozen that reside in the river habitat. Stoneflies belong to the order Plecoptera, which translates to "braided wing." As their name implies, they prefer stony bottoms of flowing rivers and streams. Stoneflies, like many other aquatic insects, hatch from the egg to the nymph stage. Depending on the species, they will spend one to three years as a nymph in the water. When they emerge as adults during early spring, they exit their water habitat and leave behind their nymph exoskeleton, much like a dragonfly. They will then mate and lay eggs to continue the lifecycle.
Black stoneflies are the first of the stonefly species to emerge from the river. Starting in the middle to late February, they can be seen in swarms over and along the river; they prefer mild afternoons with little wind. Stoneflies are food for fish, especially trout. Trout especially prefer the nymphs. Many trout fishermen carry artificial wet and dry flies simulating nymphs and adults.
If you see a swarm of stoneflies, stop somewhere safe and watch as they dance over the water and observe them close when they land nearby. They are not shy and don't bite; you may even be graced by a few stoneflies that decide you make a good perch.