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Mechanical Debridement vs. Radiofrequency-Based Debridement to Treat Articular Cartilage Legions With Partial Meniscectomy in the Knee (ACT)
This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2016 by Smith & Nephew, Inc.
Smith & Nephew, Inc.
Information provided by (Responsible Party):
Smith & Nephew, Inc.
ClinicalTrials.gov Identifier:
First received: February 15, 2013
Last updated: September 15, 2016
Last verified: September 2016
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The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or Mechanical Debridement in subjects ≥ eighteen (18) years of age.
Chondral Lesion Plus Partial Medial Meniscectomy
Device: Mechanical Debridement (Mechanical Shaver)
Device: Radiofrequency-Based Debridement
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Prospective, Double Blinded, Multicenter, Randomized, Controlled Trial to Evaluate Mechanical Debridement vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
Further study details as provided by Smith & Nephew, Inc.:
Primary Outcome Measures:
- Knee and Osteoarthritis Outcomes Scores (KOOS) [ Time Frame: 52 Weeks ] [ Designated as safety issue: No ]Change in Knee and Osteoarthritis Outcomes Scores (KOOS) scores post-operative compared to baseline
Secondary Outcome Measures:
- International Knee Documentation(IKDC)Subjective Knee Evaluation Form [ Time Frame: Screening/Baseline, Week 6, 12, 24, 36, 52 and 104 ] [ Designated as safety issue: No ]Change in International Knee Documentation (IKDC) scores from post-operative compared to baseline
- International Knee Documentation Committee (IKDC)Knee Examination Form score [ Time Frame: Weeks 6, 12, 24, 36 52, and 104 ] [ Designated as safety issue: No ]Change in International Knee Documentation Committee (IKDC) Knee Examination Form scores from baseline
- Change in Knee and Osteoarthritis Outcomes Scores (KOOS) scores [ Time Frame: Weeks 6, 12, 24, 36 and 104 ] [ Designated as safety issue: No ]Change in KOOS scores from baseline
- Visual Analogue Scale, (VAS) Knee Pain [ Time Frame: Day 10, week 6, 12, 24, 36, 52 and 104 ] [ Designated as safety issue: No ]the change from baseline
- SF-12 [ Time Frame: Weeks 6, 12, 24, 36, 52 and 104 ] [ Designated as safety issue: No ]Change in SF-12 scores from baseline
- EQ-5D-5L [ Time Frame: Day 10, weeks 6, 12, 24, 36, 52 and 104 ] [ Designated as safety issue: No ]Change in EQ-5D-5L scores from baseline
- Magnetic Resonance Imaging (MRI) [ Time Frame: Day 10, weeks 52 and 104 ] [ Designated as safety issue: No ]MRI assessments at Day 10, Weeks 52 and 104
- Subject Satisfaction [ Time Frame: Weeks 52 and 104 ] [ Designated as safety issue: No ]Subject Satisfaction at Weeks 52 and 104
|Estimated Enrollment:
|Study Start Date:
|March 2013
|Estimated Study Completion Date:
|April 2018
|Estimated Primary Completion Date:
|April 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Mechanical Debridement (Mechanical Shaver)
Mechanical shaver removes areas of damaged tissue
Device: Mechanical Debridement (Mechanical Shaver)
mechanical shaver that removes areas of damaged tissue
Other Name: Mechanical Shaver
Active Comparator: Radiofrequency-based Debridement
Electrical energy removes areas of damaged tissue (Coblation®)
Device: Radiofrequency-Based Debridement
Electrical energy that removes areas of damaged tissue (Coblation®)
Other Name: Paragon® T2™ ICW wand
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Subjects MUST meet ALL of the following criteria to be included in the study:
- Given written informed consent on the IRB/REB approved Consent Form specific to the study, prior to study participation
- Is male or non pregnant female ≥ eighteen (18) years of age
Arthroscopic confirmation of a lesion requiring treatment meeting the following parameters:
- Single, treatable chondral lesion, localized to the medial femoral condyle,
- ICRS Grade 3A,
- < 4cm2 in size
- MRI within past 6 months confirming presence of a medial femoral chondral lesion and medial meniscal tear requiring a partial meniscectomy
- Must present with pain in the index knee of moderate or severe (> 30 mm) as measured by the VAS
- Must be able to understand English (written and oral)
- Must be available to come to all study related visits and is physically and mentally willing and able to comply with all post-operative evaluations
Must be in general good health (as determined by the Investigator) based on screening assessments and medical history
Exclusion Criteria:
Subjects will be excluded from the study, if they meet ANY one (1) of the following criteria:
- Body Mass Index (BMI) > 35
- Requires bilateral knee surgery
Any of the following conditions:
- active joint infections
- is immunocompromised, has Sickle Cell disease, has a primary bone disease (e.g., Paget's disease) or disorders that may adversely affect the healing process, or is terminally ill
- inflammatory rheumatoid arthritis or other systemic inflammatory arthritis (i.e., gout)
- metastatic and/or neoplastic disease
- infectious, highly communicable diseases (e.g., active tuberculosis or active hepatitis)
- coagulation disorder or patient is receiving anti-coagulants
- documented evidence of a history (e.g. liver testing) of drug/alcohol abuse within the 12 months prior to screening for study entry
- diagnosed with a behavioral condition which could affect their ability to accurately comply with the study (e.g. developmental delay, attention deficit disorder, and autism)
Any of the following conditions in the index limb or joint:
- Grade III or greater osteoarthritis as determined by AP radiograph (Kellgren-
- systemic steroid therapy or steroid intra-articular therapy within 4 weeks of enrollment into this study
- intra-articular viscosupplementation within 3 months of enrollment into this study
- osteomyelitis, septicemia, or other infections that may spread to other areas of the body
- fractures, osteocysts or osteolysis
- recurrent patellar instability (e.g., subluxation or dislocation)
- severe Varus or Valgus knee deformities
- tear of the lateral meniscus
- avascular necrosis
- synovial disorders (e.g., pigmented villanodular synovitis)
- previous total or partial meniscectomy
- requires reconstruction or replacement of medial or lateral meniscus
- knee instability, malalignment, or patellar tracking dysfunction
- prior treatment for cartilage repair, including but not limited to ACI, Mosaicplasty and/or marrow stimulation procedures
- prior knee tendon and/or ligament repair or patellar surgery within 6 months of enrollment into this study
Any of the following conditions in the contralateral limb or joint:
- greater than minimal abnormality as shown by clinical exam and/or imaging
- scheduled or to be scheduled for surgery over the course of this study
- involvement causing abnormal ambulation and non-compliance with post-operative rehabilitation guideline
- The subject has implanted metallic devices (insulin pumps, nerve stimulators, etc), medically implanted clips or other electronically, magnetically or mechanically activated implants that would contraindicate undergoing an MRI scan of the knee
- The subject has claustrophobia that would inhibit their ability to undergo an MRI scan of the index knee
- Receiving prescription narcotic pain medication for conditions unrelated to the index knee condition
- Cardiac pacemaker or other electronic implant(s)
- Pregnant and/or intending to become pregnant during this study period
- Participated in a clinical study within 6 months prior to surgery, or who is currently participating in another clinical study.
- Is a prisoner, or is known or suspected to be transient
- Is involved with Worker's Compensation unrelated to the index knee
- Is involved with health-related litigation
Intra-operative Exclusion Criteria
Subjects will be excluded from the study, if they meet ANY one (1) of the following criteria:
- Has more than 1 chondral lesion requiring treatment
- Requires concomitant procedures (i.e., anterior cruciate ligament repair, high tibial osteotomy), excluding partial medial meniscectomy
- Has a medial meniscal tear not requiring treatment
- Has a medial meniscal tear requiring a procedure other than partial meniscectomy
- Has a lateral meniscal tear requiring treatment
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01803880
Please refer to this study by its ClinicalTrials.gov identifier: NCT01803880
|Contact: Karlie Jackson
|United States, Arizona
|Tucson Orthopaedic Institute
|Tucson, Arizona, United States, 85712
|Contact: Jelena Candito, CCRC 520-784-6446 email@example.com
|Principal Investigator: Nebosja Skrepnik, MD, PhD
|Sub-Investigator: Scott Slagis, M.D.
|Sub-Investigator: Brian Nielsen, M.D.
|Sub-Investigator: Lawrence Housman, M.D.
|United States, Florida
|Andrews Research and Education Foundation, Inc.
|Gulf Breeze, Florida, United States, 32561
|Contact: Melissa Davis, RN 850-916-8591 email@example.com
|Contact: Cassidy Shefferd, MBA 850-916-8592 firstname.lastname@example.com
|Principal Investigator: Christopher O'Grady, MD
|Sub-Investigator: Roger Ostrander, MD
|Sub-Investigator: Charles Roth, MD
|United States, Indiana
|Orthopaedic Research Foundation, Inc.
|Greenwood, Indiana, United States, 46143
|Contact: Vicki Snodgrass-Miller, CCRC 317-884-5230 email@example.com
|Principal Investigator: Jack Farr II, MD
|Sub-Investigator: Matthew Lavery, M.D.
|United States, Ohio
|Ohio State University
|Columbus, Ohio, United States, 43221
|Contact: Isac Kunnath 614-293-2410 mailto:email@example.com
|Principal Investigator: David Flanigan, MD
|United States, Pennsylvania
|University Orthopedics Center
|State College, Pennsylvania, United States, 16801
|Contact: Sue Jepson, RN 814-272-3751 email@example.com
|Contact: Jill Fremberg, MS 814-272-3691 email@example.com
|Principal Investigator: Douglas Roeshot, MD
|Sub-Investigator: Thomas J Ellis, DO
|Sub-Investigator: Paul Sensiba, MD
|Sub-Investigator: Chris S. McClellan, DO
|United States, Texas
|Methodist Center For Orthopedic Surgery
|Active, not recruiting
|Houston, Texas, United States, 77070
|Basin Orthopedic Surgical Specialists
|Odessa, Texas, United States, 79761
|Contact: Debbie Mossbarger, CCRP 432-853-5567 email@example.com
|Contact: Peggy Ludi, RN, CCRC 432-332-2663 email@example.com
|Principal Investigator: Steven C Riley, MD
Sponsors and Collaborators
Smith & Nephew, Inc.
|Principal Investigator:
|Jack Farr II, MD
|Orthopaedic Research Foundation, Inc.
More Information
Keywords provided by Smith & Nephew, Inc.:
ClinicalTrials.gov processed this record on December 09, 2016
|Responsible Party:
|Smith & Nephew, Inc.
|ClinicalTrials.gov Identifier:
|NCT01803880 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 15, 2013
|Last Updated:
|September 15, 2016
|Health Authority:
|United States: Institutional Review Board
Keywords provided by Smith & Nephew, Inc.:
Articular cartilage
Cartilage lesion
Cartilage defect
MR imaging
Mechanical debridement
Mechanical shaver
Torn meniscus
Arthroscopic knee surgery
Damaged cartilage
ClinicalTrials.gov processed this record on December 09, 2016

subset: commoncrawl


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Their fixtures, following the World Club Challenge, as usual these days being held in England, are horrendous.
Looking at the WCC and the quick turn round expected following on from it has Craig Bellamy and his club "seething".
There's the threat of not playing the WCC fixture if the chance arises in future season and closer to the present resting some of their first choice players in the R2 game against Cowboys, or even the Grand Final rematch with Bulldogs.
The Storm travel to the bitter cold of the UK for the World Club Challenge against Leeds on February 22 and just three weeks later will be in the tropical heat of North Queensland against the Cowboys for round two. Five days later they have a Thursday night blockbuster against the Bulldogs.
"To me it is not giving consideration to a player's welfare," he told The Daily Telegraph.
Asked if he would consider withdrawing players, Bellamy didn't hesitate: "If I had to I would, without a doubt. I am not going to take any chances with my players' health.
"I can't believe they haven't taken our trip to Townsville into consideration."
The Storm also have four five-day turnarounds during the season, more than any other club.
The AFL has a policy where no out-of-Melbourne team has a less than six-day turnaround between games.
By the way some of us live in the 'bitter cold of the UK' - aren't we the tough ones! Having said that I suspect that Barney is hibernating in his cave for the winter wrapped in straw and fluff!
Edited by G Las D, 18 December 2012 - 10:08 PM.


text:
An ex-ball boy for the Utah Jazz is auctioning off a pair of shoes from Michael Jordan's infamous "flu game" in 1997.
Preston Truman has been hiding the pair of kicks autographed by the NBA great for 16 years in a safety deposit box.
Now he said it's time to bring the shoes out of hiding and tell the story of how Jordan gave him the shoes after game 5 of the NBA finals.
"It's not about the money. I just want someone to take them and display them better than I can," Truman said.
Truman was 18 when he first met Jordan as a ball boy for the Jazz. It was 1996, and he said he got the attention of the basketball great before one game when Jordan asked his trainer for his usual snack of apple sauce and graham crackers.
The trainer had only crackers, no apple sauce.
Eager to please his basketball hero, Truman ran around the Delta Center "like a crazy person" looking for apple sauce. He returned to the locker room with a huge can of the apple sauce and a can opener.
"He said 'wow, you really came through," recalled Truman of Jordan's reaction.
When the Bulls returned to play the Jazz in June of 1997, Truman said he went to the store, bought apple sauce and graham crackers and left them in the locker room for Jordan, who said, "Oh, you remembered, huh?"
In the 1997 game, Jordan showed up to Utah sick with the flu. As he rested in the locker room before the game, the young ball boy said he found the courage to tell him, "I'd love a pair of your kicks after the game."
Jordan responded, "They are yours."
Jordan, who was visibly sick during the game, scored 38 points and helped the Bulls defeat the Jazz en route to another NBA title.
After the game, Truman said he was cleaning up and saw the equipment manager try to take the shoes.
"No. those are for him," Truman recalled Jordan saying.
A security guard snapped a picture of the basketball great as he signed the shoes, and they have stayed intact since -- except for the time Truman's mom tried to wipe off the scuff marks.
Truman stopped her before she put the rag to the shoe.
Bidding starts on Nov. 18 on the sports auction site www.greyflannel.com.


text:
Some of you know recently I've been struggling with my bfing situation; little support at work, hate the pump, worried my DS is ready to wean anyway. It's been very upsetting, to say the least!!
Last Saturday I'm thrilled to say we celebrated Samuel's first birthday!! (I wanted to post before now, but DH has been HOGGING the computer )
Not only did we make it to a year, but what I feared was weaning has turned out to be a strike I guess, 'cause now he's going strong as ever. Of course, some days he isn't as interested as others depending on how busy he gets. You know how that goes ; but for the most part, we are enjoying a very sweet bfing relationship. I'm getting more flack than ever from friends and coworkers now that he's one, but I don't care 'cause I get to post on "extended breastfeeding" and not "weaning" which means the world to me right now. I see why it's even sweeter not that he's one, Kelly Ann; I get to gaze into that beautiful face and see the wonderful person he's becoming through a reflection of the tiny baby he once was. There's nothing better than this in the whole world.
Thanks for your continued support ladies! Yippee, we made it to a year!!!


text:
CHARLESTON, W.Va. — The chief of operations for the state Regional Jail Authority may be fired after a court hearing for his aggravated DUI arrest is held in late June.
John L. King II was suspended without pay after he was arrested in April for driving with a blood alcohol level of 0.239, according to a criminal complaint filed after King was arrested in South Charleston, W. VA. The legal limit is 0.08.
Joseph DeLong, deputy secretary of the Department of Military Affairs and Public Safety, said the department suspends employees without pay when they are arrested for a DUI or similar offense, and makes a decision on their employment after the court case is concluded.
DeLong also said that the department usually fires the employee if he or she is convicted.
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According to DeLong, King was highly involved in the suspensions and firings of many regional jail employees prior to his own suspension, making him familiar with the department's standards and procedures.
King is a will-and-pleasure employee for the Regional Jail Authority, meaning he can be fired at any time and for any reason. But since he is a high-ranking jail official, the department extended a policy to King that protects covered employees, so that he would not be fired immediately.
John Lopez, director of programs for the regional jails, has stepped into King's position on an interim basis.
King, a South Charleston resident, is the son of former South Charleston Police Chief John King, who served as chief for ten years in the 1960s and 1970s.


text:
HI everyone. I am new here and have been trying to weed through past posts to see if someone else already addressed this, but it was a task that proved overwhelming.
Anyway I am new mom- I have a 10 week old son. I am having a lot of trouble nursing. So far I have had 5 plugged ducts and mastitis 3.5 times (that 1/2 of a time I think I caught it early and nipped it in the bud) and a 7 week long case of thrush.
I was dealing with a self diagnosed case of "over supply". There were popping and clicking sounds during let down. I was engorged before every feeding and especially so in the morning- Leo was sleeping in 8 hour stretches at 4 weeks. He is also spitting up and projectile vomiting constantly. I should note he is growing like a week. He's nearly doubled his body weight and grown 5 inches in these 10 weeks.
Now suddenly it's.. gone. I always feel totally empty, the baby wants to nurse constantly and he's not having many wet diapers. We went form 10 or 12 a day to 4. I can't get ANYTHING when I pump. So I guess this is the part where I panic that I don't have enough milk? Help?
Thanks in advance


text:
The event is held Saturday, Sept. 20 and immediately after the parade from noon until 6 p.m., in the big tent at the main event area there will be a D.J. with music and karaoke. Sponsors are needed for this event. Also looking for people to sing during the karaoke portion from 2-6 p.m.
A Golf Tournament will be held July 26 at the Karnes County Country Club starting at 10 a.m. The entry fee is $100 to enter. Sponsors and players are needed.
Please call Lavonne Murphy at 210-906-4083, if you would like to help or have any question.


text:
Bradi Smith's guess of 112 pieces made her the lucky winner of the jar of candy.
Patsy Perez was the lucky winner of the drawing for the book, "A Dazzle of Dragonflies.
"Congratulations to our winners, and thank you to all our patrons who helped us celebrate National Library Week," said Tina McGuill, director of the library.
Library patrons win prizes


text:
Computerized Polygraph > LX4000 Polygraph System > LX4000 Systems
The LX4000 Computerized Polygraph System records, stores, and analyzes physiological changes during a polygraph examination. The LX4000 system combines conventional polygraph procedure with sophisticated state of the art technology. Results are derived from the following traditional physiological parameters:
We currently offer a Plethysmograph (PPG) Model 76604A-5L with an adaptor (Model 76604ADP) to measure finger pulse and blood volume. A total of seven channels can be recorded at one time.
Charts are recorded in much the same manner as conventional polygraph instrumentation with a smooth scrolling display moving from right to left. The tracings recorded are in real-time and are truly rectilinear, so charts can be easily interpreted. See polygraph software page for a sample of the tracings. The system can be operated using a mouse / pointing device or the keyboard.
Conventional Polygraph Accessories
Find Lafayette


text:
Event #4990
October 9, 2003
Grand Hyatt Washington, Washington, DC
The U.S.-Sweden Defense Industry Conference was organized by the following organizations:
National Defense Industrial Association
Association of Swedish Defence Industries
Exportrådet, the Swedish Trade Council
The 10th U.S.-Sweden Defense Industry Conference was held in Washington, DC on 9 October 2003. The conference objectives were for participants to obtain a firsthand review of Swedish and U.S. procurement and acquisition policies and strategies and to enhance U.S.-Sweden defense cooperation, technology transfer, and trade.
The theme of this conference was "Half a Century of Successful Cooperation - A Foundation for the 21st Century." Acknowledging a half century of successful defense industrial partnering, Swedish and American industrialists are setting the course for the 21st Century. Discussions highlighted Swedish - American partnering opportunities, while keeping in mind the broader transatlantic defense industry challenges and opportunities. This day-long conference brought together people who are making that happen. Meet with senior Swedish and U.S. government officials and industry decision makers representing aircraft, ammunitions, radar, electronics, command and control, information technology systems, and more.
This conference was organized by the National Defense Industrial Association, the Swedish Trade Council, and the Swedish Federation of Defense Industries and had the support of the U.S. Department of Defense and the Ministry of Defense of Sweden.
After the conference, the Swedish Ambassador, H.E. Jan Eliasson, hosted a buffet reception at the Ambassador's residence.
- Top of Page -
All of the following are in PDF format.
October 8, 2003
Presentations on October 8th:
10th U.S.-Sweden Defense Industry Conference–Peter Dahlström
U.S. & Sweden: Then & Now–Lars Jäderblom
Trade Facts, Investment & Employment, Trade Policy Issues–Sven-Olof Johansson
New U.S. Program Management Model: The Role of the Lead Systems Integrator–Ken Medlin
A Roadmap to the Future Defense Industrial Base–Suzanne Patrick
Deepwater–Patrick M. Stillman
Trans-Atlantic Acquisitions: Lessons Learned in the Marketplace Through United Defense Industries' Acquisition of Bofors Defense–David K. Wallestad
Trans-Atlantic Acquisitions: Lessons Learned–Mats Warstedt
Presentations on October 9th:
Security of Supply from a Swedish Perspective–Stephan Källmén
European Multilateral Cooperation: A Swedish View–Stephan Källmén
Swedish Armed Forces: Network Based Defense Trends–LTG Johan Kihl
Future Trends in Network Centric Warfare–LTG Johan Kihl
US and Swedish Industrial Support to Network Centric Warfare for US and Swedish Forces–Erik Löwenadler
Network Enabled Operations & Defense Industrial Restructuring–Jerry McElwee
US and Swedish Industrial Support to Network Centric Warfare for US and Swedish Forces–Frank McGhee
Excalibur: A successful Swedish/U.S. Development Program–COL Nate Sledge
Sweden Views on Defense Industrial Restructuring and Globalization: A Saab Perspective–Åke Svensson


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Home List of Titles Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/191227
- Title
- Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses
- Author(s)
- Vogalis, F.; Shiraki, T.; Kojima, D.; Wada, Y.; Nishiwaki, Y.; Jarvinen, J. L. P.; Sugiyama, J.; Kawakami, K.; Masai, I.; Kawamura, S.; Fukada, Y.; Lamb, T. D.
- Abstract
- When rod and cone photoreceptors in the eye respond to light, they need to recover, and the first step in recovery involves a protein called G-protein receptor kinase (GRK). Rods, which underlie night vision, employ a variant called GRK1, whereas cones, which mediate day vision, typically employ a variant called GRK7. We have engineered rod cells in the zebrafish retina that additionally express the cone variant, GRK7. By recording electrically from these modified rods, we have found that they are less sensitive to light than normal rods, in that regard mimicking cones. We have also found evidence to suggest that the size of the cell's response to a single photon (the smallest particle of light) is normal when recovery is mediated by GRK1, but is small (and hence somewhat cone-like) when mediated by GRK7. These results help us understand the differences between rod and cone photoreceptors. To investigate the roles of G-protein receptor kinases (GRKs) in the light responses of vertebrate photoreceptors, we generated transgenic zebrafish lines, the rods of which express either cone GRK (GRK7) or rod GRK (GRK1) in addition to the endogenous GRK1, and we then measured the electrophysiological characteristics of single-cell responses and the behavioural responses of intact animals. Our study establishes the zebrafish expression system as a convenient platform for the investigation of specific components of the phototransduction cascade. The addition of GRK1 led to minor changes in rod responses. However, exogenous GRK7 in GRK7-tg animals led to lowered rod sensitivity, as occurs in cones, but surprisingly to slower response kinetics. Examination of responses to long series of very dim flashes suggested the possibility that the GRK7-tg rods generated two classes of single-photon response, perhaps corresponding to the interaction of activated rhodopsin with GRK1 (giving a standard response) or with GRK7 (giving a very small response). Behavioural measurement of optokinetic responses (OKR) in intact GRK7-tg zebrafish larvae showed that the overall rod visual pathway was less sensitive, in accord with the lowered sensitivity of the rods. These results help provide an understanding for the molecular basis of the electrophysiological differences between cones and rods.
- Publication type
- Journal article
- Research centre
- Swinburne University of Technology. Faculty of Life and Social Sciences
- Source
- The Journal of Physiology, Vol. 589, no. 9 (May 2011), pp. 2321-2348
- Publication year
- 2011
- FOR Code(s)
- 060602 Animal Physiology - Cell; 060111 Signal Transduction; 110906 Sensory Systems
- Keyword(s)
- GRK; G-protein receptor kinase; Night vision; Photoreceptors; Photosensitivity; Retinas; Zebrafish
- Publisher
- Blackwell Publishing
- 0022-3751
- Publisher URL
- Copyright
- Copyright © 2011 The authors. Journal compilation © 2011 The Physiological Society.
- Additional information
- This article is accompanied by supplementary information on the journal's website. See: http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2010.204156/suppinfo.
- Peer reviewed


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Dearest Feedback Nerds,
Feedback will go up tomorrow, hopefully by 3PM ET. We are very sorry for the delay. Please know that I've personally pummelled the responsible parties to within an inch of their lives for this horrible transgression. I can assure you that The Feedback Audio Oompa Loompas will not make this mistake again.
In all seriousness we appreciate your continued support and understanding. We're constantly striving to make Feedback more awesomer, and occasionally said striving leads to technical issues... which we have since sorted out.
In the meantime, please enjoy all of the epic Gamescom content the Germany away team is sending back. There will be a ton more trailers, previews, exclusive interviews and schnitzel this week and next. And if they don't come back with photos of Jake Gaskill in lederhosen, someone will be getting fired.


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|The History of Rigpa
Today many people around the world have encountered Tibetan Buddhism, and derived enormous benefit from its teachings and practice. One of the direct causes for its remarkable spread was the arrival in the West in the 1960's and 1970's of a number of Tibetan teachers, who devoted themselves to discovering how their ancient Buddhist tradition could be placed within the reach of modern men and women.
Born in Kham in eastern Tibet, Rinpoche was recognized and enthroned as the incarnation of Lerab Lingpa Tertön Sogyal by Jamyang Khyentse Chökyi Lodrö, one of the most outstanding masters of the twentieth century. Jamyang Khyentse supervised his training and raised him as a son. When conditions deteriorated in Kham, Khyentse Rinpoche and his young disciple left for Central Tibet and Lhasa, where in 1955, for the first time, they met His Holiness the Dalai Lama. They then continued to India on pilgrimage, and Jamyang Khyentse finally settled in Gangtok at the invitation of the Chögyal—the king—of Sikkim. It was there that he passed away in 1959.


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MADISON, Wis. (AP) -- State election officials say local clerks have issued at least 206,000 absentee ballots for Tuesday's recall elections.
Democrats have forced Republican Gov. Scott Walker and four other GOP officeholders into recalls as payback for passing a polarizing law last year that all but ended most public workers' collective bargaining rights. Walker faces Democrat Tom Barrett Tuesday in a rematch of the 2010 gubernatorial contest.
Voters cast 231,000 absentee ballots in that race. According to the state Government Accountability Board, local clerks that use a statewide computer system to track absentee voting have issued 206,128 ballots this time.
The actual number of ballots issued is probably much higher. Only a third of clerks use the tracking software and they'll keep adding data beyond the election.


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Welcome to the CRG Discussion Forum!Forum registration problems: Make sure you enter your email correctly and you check your spam box first. *Then* email KurtS2@gmail for help.
It looks very good the way it is Jack.. Did it originally have a white vinyl top??
Give me your email and I can suggest someone for you, he did my J2 68' Z28. It had lost it's top many many years ago and it's going back on as we speak.


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March 13, 2013 —
BETHEL, NY — Celebrate St. Patrick's Day with a party at the Catskill Distilling Company on Saturday, March 16 at 8 p.m., featuring the Somerville Brothers, whose music is a blend of contemporary country with rock and roots.
Handcrafted spirits by the distillery, local craft beers and other St. Patrick's Day tipples will be available for purchase in the Tasting Room overlooking the copper still. Next door, The Dancing Cat Saloon will offer meal specials including corned beef and cabbage and shepherd's pie all weekend.
The following day, March 17, The Dancing Cat Saloon will honor of Women's History Month with a special jazz brunch starting at 11:30 a.m. Jazz songstress Donna Singer will lead a show celebrating women who have helped shape the history of music, backed up by The Doug Richards Trio and local female vocalists.
Visit www.dancingcatsaloon.com [1], or www.catskilldistillingcompany.com [2].


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It is quite amazing the way that smell reminds us of places, people, things and feelings. The sense of smell is the strongest and most primal of all our senses. It protects us from drinking milk that's turned sour and it vividly reminds us of what we experienced decades ago. It is the first of our senses to evolve in the evolutionary chain and the sense with the strongest, most accurate level of recall.
When I was asked to write for It's My Time, the Global Casting for United Colors of Benetton, I couldn't stop thinking about my adolescence that was marked by the smell of the brand perfume Colors.
First summer love, vacations at the beach, family union, friends that last until today and me being a very happy teenage girl! The perfume wasn't mine and I only saw it and smell it during those vacations in 1992. Today, if I close my eyes I can scent it as if it is right here. Back then I couldn't afford to buy it. Some years later it had stock out from shops. I never had it and probably will never find it, however my all life will always smell like Colors spirit.
Is there a better trend than to make your brand smell?


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College of Undergraduate Studies
Hello everyone! Make sure you have everything for orientation:
- New Student Orientation registration mailed by deadline
- All pertinent University correspondence (i.e., medical forms, housing, etc.) mailed by deadline
- Toiletries
- Pillow/blanket if preferred (NSO will provide bedding for the new students)
- Comfortable clothing
- Sneakers
- Flip-flops for shower
- A sense of adventure and enthusiasm
- An open mind to new experiences
If you have a question about the items you should bring, feel free to call us at 610-647-4400 ext. 3117 or e-mail email@example.com.


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Note: Firm is no longer in business. The repair kit is no longer available. If you do not have the repair kit, stop using and discard this product.
WASHINGTON, D.C. - The U.S. Consumer Product Safety Commission, in cooperation with the firm named below, today announced a voluntary recall of the following consumer product. Consumers should stop using recalled products immediately unless otherwise instructed. It is illegal to resell or attempt to resell a recalled consumer product.
Name of Product: Amby Baby Motion Beds
Units: About 24,000
Manufacturer: Amby Baby USA, of Minneapolis, Minn.
Hazard: The side-to-side shifting or tilting of the hammock can cause the infant to roll and become entrapped or wedged against the hammock's fabric and/or mattress pad, resulting in a suffocation hazard.
Incidents/Injuries: Amby Baby is aware of two infant suffocation deaths in the Amby Baby hammock. In June 2009, a 4-month-old girl in Lawrenceville, Ga died in a baby hammock and in August 2009, a 5-month-old boy from Gresham, Ore.
Description: The Amby Baby Motion Bed consists of a steel frame and a fabric hammock which are connected by a large spring and metal crossbar. There is only one model of the hammock available which can be identified by a label sewn onto the hammock stating: "Amby – Babies Love It, Naturally."
Sold online at: Ambybaby.com and other Internet retailers from January 2003 through October 2009 for about $250.
Manufactured in: China
Remedy: This firm is no longer in business. The repair kit is no longer available. Consumers who have not received the repair kit should immediately stop using this product and discard it.
The U.S. Consumer Product Safety Commission is charged with protecting the public from unreasonable risks of injury or death associated with the use of
thousands of types of consumer products under the agency's jurisdiction. Deaths, injuries, and property damage from consumer product incidents cost the
nation more than $1 trillion annually. CPSC is committed to protecting consumers and families from products that pose a fire, electrical, chemical or
mechanical hazard. CPSC's work to help ensure the safety of consumer products - such as toys, cribs, power tools, cigarette lighters and household
chemicals -– contributed to a decline in the rate of deaths and injuries associated with consumer products over the past 40 years.
Federal law bars any person from selling products subject to a publicly-announced voluntary recall by a manufacturer or a mandatory recall ordered by the
To report a dangerous product or a product-related injury go online to www.SaferProducts.gov or call CPSC's Hotline at 800-638-2772 or teletypewriter at
301-595-7054 for the hearing impaired. Consumers can obtain news release and recall information at www.cpsc.gov, on Twitter @USCPSC or by subscribing
to CPSC's free e-mail newsletters.
Times: 8 a.m. - 5:30 p.m. ET; Messages can be left anytime
Call to get product safety and other agency information and to report unsafe products.
Please use the below phone number for all media requests.
Phone: (301) 504-7908
Spanish: (301) 504-7800
View CPSC contacts for specific areas of expertise
We are still interested in receiving incident or injury reports that are either directly related to this product recall or involve a different hazard with the same product.
Report a Product on SaferProducts.gov
The link you selected is for a destination outside of the Federal Government. CPSC does not control this external site or its privacy policy and cannot attest to the accuracy of the information it contains. You may wish to review the privacy policy of the external site as its information collection practices may differ from ours. Linking to this external site does not constitute an endorsement of the site or the information it contains by CPSC or any of its employees.
Click Ok if you wish to continue to the website; otherwise, click Cancel to return to our site.


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by Anton Shilov
Dirk Meyer, chief executive officer of Advanced Micro Devices, on Monday resigned from the company. The board of directors in a joint statement implied that Mr. Meyer failed to ensure rapid growth for the company and that a new leader would do it better. The departure of Mr. Meyer marks the second resignation of CEO at AMD in less than two years.
"Dirk became CEO during difficult times. He successfully stabilized AMD while simultaneously concluding strategic initiatives including the launch of Globalfoundries, the successful settlement of our litigation with Intel and delivering Fusion APUs to the market. However, the board believes we have the opportunity to create increased shareholder value over time. This will require the company to have significant growth, establish market leadership and generate superior financial returns. We believe a change in leadership at this time will accelerate the company's ability to accomplish these objectives," said Bruce Claflin, the chairman of AMD.
Dirk Meyer resigns from the company after about fifteen years at AMD. Under the leadership of Dirk Meyer AMD developed its first high-end microprocessor – the AMD Athlon – in the late nineties. He became the chief exec of AMD in mid-2008, when Hector Ruiz stepped down after making a series of decision that lead to AMD's loss of leadership on the server market and resignation of many key people from the former ATI Technologies and also losses on the graphics chips market.
Even though Mr. Meyer succeeded in stabilizing AMD financially, managed to get its roadmap back on track and launched a number of leading-edge products, he still could not make the company profitable. While the exact reasons for the step down are unclear, perhaps, the board of directors wants the new chief exec to make more radical decision than Mr. Meyer did. Still, it is unclear how much more radical it is possible to be: Meyer laid off thousands of people and was one of the driving force behind spinning-off the manufacturing facilities.
A CEO search committee has been formed to begin the search for a new CEO. The committee is led by Bruce Claflin, chairman of AMD's board of directors, who has been named executive chairman of the board as he assumes additional oversight responsibilities during the transition period. Thomas Seifert will maintain his current responsibilities as CFO and has asked not to be considered for the permanent CEO position. Mr. Seifert joined AMD in 2009. Immediately prior to joining AMD, Seifert served as COO and CFO of Qimonda AG, where he led the formation and subsequent IPO of the company. At Infineon AG, Seifert served as senior vice president and general manager in its wireless business group.
"AMD enters 2011 with considerable product and financial momentum. Our roadmap for the year, including our Llano APU and 32nm Bulldozer based processors remain on track. I believe we have significant opportunities to cement our leadership positions in several key market segments based on the strength of our upcoming products," said the interim chief executive.
AMD also announced certain preliminary results for the fourth quarter 2010. Fourth quarter revenue increased 2% sequentially to approximately $1.65 billion and gross margin was approximately 45%. In addition, the company reaffirms its 2011 annual financial guidance as disclosed at its financial analyst day last November.


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Deeplinks Blog posts about Cyber Security Legislation
Cyber, Cyber, Cyber. The word makes most technical people cringe but it's all the rage right now in DC and other policy circles. The rallying calls are now familiar and the central pitch is that private entities and networks—the buzzword is "critical infrastructure"—should be strongly incentivized to "share" information with the government. In other words, providers should surrender more of their and their customers' privacy. There's much danger there and EFF continues to sound the alarm.
CISPA-like zombie bills continue to rattle around Congress. After the Obama Administration released its own computer security information sharing bill a few weeks ago, Democratic Senator Tom Carper followed through with The Cyber Threat Sharing Act of 2015. The bill mirrors the Obama Administration's information sharing proposal.
EFF Joins Civil Society and Computer Security Experts to Call for Rejection of Flawed Cybersecurity Legislation
EFF has joined 26 civil society organizations and 22 computer security experts in a letter that calls on the Senate Select Committee on Intelligence to reject the Cybersecurity Information Sharing Act of 2015 (CISA).
The Obama Administration is on a roll with proposing legislation that endangers our privacy and security. Over the course of two days, President Obama proposed a cybersecurity bill that looks awfully similar to the now infamous CISPA (with respect to information sharing), a computer crime bill that is the opposite of our own proposed computer crime reform, and a data breach law weaker than the current status quo. All three of the bills are recycled ideas that have failed in Congress since their introduction in 2011. They should stay on the shelf.
Zombie Bill Dead in 2013, Stumbles from the Grave in 2015
More needs to be done to protect cyberspace and enhance computer security. But President Obama's cybersecurity legislative proposal recycles old ideas that should remain where they've been since May 2011: on the shelf. Introducing information sharing proposals with broad liability protections, increasing penalties under the already draconian Computer Fraud and Abuse Act, and potentially decreasing the protections granted to consumers under state data breach law are both unnecessary and unwelcome.
Information Sharing
Subscribe to EFF Updates
Deeplinks Archives
Deeplinks Topics
- Fair Use and Intellectual Property: Defending the Balance
- Free Speech
- Innovation
- UK Investigatory Powers Bill
- International
- Know Your Rights
- Privacy
- Trade Agreements and Digital Rights
- Security
- State-Sponsored Malware
- Abortion Reporting
- Analog Hole
- Anonymity
- Anti-Counterfeiting Trade Agreement
- Artificial Intelligence & Machine Learning
- Biometrics
- Bloggers' Rights
- Border Searches
- Broadcast Flag
- Broadcasting Treaty
- Cell Tracking
- Coders' Rights Project
- Computer Fraud And Abuse Act Reform
- Content Blocking
- Copyright Trolls
- Council of Europe
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- CyberSLAPP
- Defend Your Right to Repair!
- Development Agenda
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- Digital Video
- DMCA Rulemaking
- Do Not Track
- E-Voting Rights
- EFF Europe
- Electronic Frontier Alliance
- Encrypting the Web
- Export Controls
- FAQs for Lodsys Targets
- File Sharing
- Fixing Copyright? The 2013-2016 Copyright Review Process
- Genetic Information Privacy
- Government Hacking and Subversion of Digital Security
- Hollywood v. DVD
- How Patents Hinder Innovation (Graphic)
- International Privacy Standards
- Internet Governance Forum
- Law Enforcement Access
- Legislative Solutions for Patent Reform
- Locational Privacy
- Mandatory Data Retention
- Mandatory National IDs and Biometric Databases
- Mass Surveillance Technologies
- Medical Privacy
- Mobile devices
- National Security and Medical Information
- National Security Letters
- Net Neutrality
- No Downtime for Free Speech
- NSA Spying
- Offline : Imprisoned Bloggers and Technologists
- Online Behavioral Tracking
- Open Access
- Open Wireless
- Patent Busting Project
- Patent Trolls
- Patents
- PATRIOT Act
- Pen Trap
- Policy Analysis
- Printers
- Public Health Reporting and Hospital Discharge Data
- Reading Accessibility
- Real ID
- Reclaim Invention
- Search Engines
- Search Incident to Arrest
- Section 230 of the Communications Decency Act
- Shadow Regulation
- Social Networks
- SOPA/PIPA: Internet Blacklist Legislation
- Student Privacy
- Stupid Patent of the Month
- Surveillance and Human Rights
- Surveillance Drones
- Terms Of (Ab)Use
- Test Your ISP
- The "Six Strikes" Copyright Surveillance Machine
- The Global Network Initiative
- The Law and Medical Privacy
- TPP's Copyright Trap
- Trans-Pacific Partnership Agreement
- Travel Screening
- Trusted Computing
- Video Games
- Wikileaks
- Transparency
- Uncategorized


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PLEASE NOTE: In the past, ICBA has received several reports that unaffiliated third-party travel agents and wholesalers have been contacting ICBA listed attendees and exhibitors offering them deals on hotels for the ICBA Convention. While it is not illegal for a travel firm or booking agent to solicit potential customers, it can be difficult to determine the legitimacy of offers from these organizations. ICBA does not utilize third-party brokers for its hotel bookings. If you don't make your housing reservations directly with the convention hotel as instructed by ICBA, we will not be able to assist you.
The Hilton Hawaiian Village ICBA BLOCK OF ROOMS IS FULL. There may be rooms available at the Hilton but our group rate no longer is available.
Honolulu does have other hotels in the Waikiki Beach area with a variety of services and room rates. To find a property that suits your needs, you can click on this Google Maps link. The link takes you to the area surrounding the Hilton Hawaiian Village.
PLEASE NOTE: ICBA does not control any hotel rates offered outside of an ICBA room block. If you book from the Google Maps page, or any web site, whether it is Orbitz, Travelocity or the home page of the hotel (which is often the best way to book), please read all terms and cancellation policies carefully.
Discover the unique environment and culture of Hilton Hawaiian Village® Waikiki Beach Resort. Imagine lush tropical gardens, waterfalls, exotic wildlife and priceless artwork. This one-of-a-kind Honolulu Hawaii hotel resort is the only true resort property in Waikiki. Relax in the comfortable accommodations. Enjoy 20 restaurants and lounges. Shop for the perfect souvenir. Experience a full range of activities for the entire family. Embark on an adventure of a lifetime - just steps from your door. 22 acre oceanfront resort with the most swimming pools and waterslides Waikiki's widest stretch of beach Duke Kahanamoku Lagoon for swimming and fun Mandara Spa & Fitness Center Waikiki Starlight Luau at resort Cultural activities including lei making, hula, and ukulele lessons More family activities and more for kids to do Nightly Hawaiian entertainment Just 20 minutes from Honolulu International Airport (HNL) Camp Penguin – located in the Diamond Head Tower. Daily activities for Children 5-12 years of age. Requires 24 hour advance registration and fees apply.
BY PHONE: When making reservations by phone, please reference the ICBA Convention so you will be noted as an attendee, however the group rate will not apply. Call 1-808-949-4321 Hilton Hawaiian Village In-House Reservations (available 8:00 a.m. – 4:00 p.m. Hawaiian Time and closed on major holidays) Call 1-800-HILTONS (445-8667) Hilton Central Reservations (available 24 hours).
Optional Resort Charge*: There is no resort charge for ICBA, however when attendees check in they can opt-in to purchase the resort charge benefits at $30.00 plus tax per day the Resort. Charge includes the following: Local, Toll-Free and Credit Card calls (no access fee) High Speed Internet Access / WIFI access PlayStation 3 with unlimited movies and games.
Hawaiian Cultural Activities: Lei making, Hula lessons, Ukulele lessons, Game and Crafts for Kids, Tahitian lessons, Hula aerobics. A flyer with the activity type and schedule is provided to each guest when they check in.
*Resort charge and inclusions may change without notice. Internet Access in guest room: Attendees have the option to purchase internet access separately, if they don't opt-in for the daily Resort charge. Cost for internet is $16.74 (248 GB) or the premium internet $20.93 (1058 GB) per 24 hours.**
**Internet cost may change without notice.


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Syracuse Vocal Ensemble, one of New York's finest choral organizations, joins forces with sparkling bluegrass instrumental talents for a genre-blending performance of The World Beloved: A Bluegrass Mass, by contemporary composer Carol Barnett, along with other works drawing on Appalachian folk traditions. Performed with regional bluegrass luminaries Joe Davoli, Perry Cleaveland, Zachary Fleitz, John Cadley, Nick Piccininni and Maureen Henesey and the Syracuse Country/Contra Dancers. (Audience members are invited onto the dance floor after the concert.)
Guests may park in King, Sheldon & Rich Hall lots E15, E27, E29 & E23; Campus Parking Map


text: I also wanted to mention that I think a lot of moms associate clingy behavior with nursing. But now that Joe is actively weaning, it's easier for me to see that in fact, he can be clingy and needy without asking to nurse. Now, when he was nursing a lot, clinginess was associated with lots of nursing. But NOT nursing hasn't made the clinging any better - sometimes, it seems like Joe is even MORE clingy! So it's good to remember that, nursing or not, babies are demanding and parenting is SUPER hard work. Just my two cents.


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A quick and easy way to attach leader to fly line or the backing to the line.
Comment by Tad Nunez - June 10 2014 @ 12:25 PMNot a comment about the product, which is fine, but about the excellent service from Blue Quill. Thanks for sending out the right item after I bought the wrong item...much appreciated.User Rating:


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The first successful manned Apollo mission launches, John Lennon releases the song "Imagine," George Washington gets a posthumous promotion, and Anita Hill accuses Clarence Thomas of sexual harassment, all on this day.
1910: Former President Theodore Roosevelt becomes the first U.S. president to fly in an airplane. He flew for four minutes with Arch Hoxsey in a plane built by the Wright Brothers at Kinloch Field in St. Louis, Missouri.


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PITTSBURGH, PA (April 11, 2008)- The Allegheny County Airport Authority authorized the expansion of its airport display advertising program at Pittsburgh International Airport (www.FlyPittsburgh.com) while also reconfirming its commitment to promoting the region through displays and public art.
The opportunities for advertising are changing with the shift in passenger traffic at Pittsburgh International Airport. As Pittsburgh International Airport becomes an origination and destination airport, the marketing opportunities for advertising are shifting more to the center core of the Airside Terminal, transit level and baggage claim level.
"As more travel begins and ends here, there is renewed interest in exploring revenue opportunities on overhead panels above escalators in high traffic areas such as the airside core and the landside baggage claim area. We are in the process of revising the entire display program with the intent to create new opportunities for advertising which in turn generates new revenue for the Airport Authority," said Bradley D. Penrod, Executive Director/CEO, Allegheny County Airport Authority. Non-aviation revenue can help reduce the fees charged to the airlines, a means of keeping Pittsburgh International Airport competitive and desirable for airline expansion.
A site under consideration is an overhead panel above escalators where all arriving passengers whose destination is Pittsburgh pass. The Airport Authority is seeking an advertiser who would make this area a distinct Welcome to Pittsburgh promotion where the region's qualities, beauty and benefits could be displayed. The Authority has approval of all advertising at the airport.
The Airport Authority also announced the expansion of its regional asset display program designed to promote the qualities of western Pennsylvania. "The public is very familiar with the Carnegie Museum of Natural History T. rex exhibit which promotes our leadership in dinosaur discoveries and the Heinz History Center's Franco Harris/George Washington statues exhibit that promotes our region's rich history. We have also presented programs with the Pittsburgh Glass Center and currently display two Glass Mosaics on the transit level featuring Old Pittsburgh and New Pittsburgh. We are currently promoting Pittsburgh 250 and hosting the Manchester Craftsmen Guild's Cera[m!x} exhibit in display cases throughout the airport, in conjunction with the National Council on Education for the Ceramic Arts," Penrod added.
Other programs under consideration include Tour of PA bicycle competition, "Recycle Runway" to coincide with the National Recycling Coalition conference later this year, a display with the National Aviary. The Airport Authority is also working with Family Communications to refurbish and enhance the Mister Rogers display.
Additionally, the Airport Authority will be seeking input from the Pittsburgh art community in development of an art in the airport program.
Chief Executive Dan Onorato has indicated that he is pleased that the Airport Authority is committed to promoting public art and intends to invite art advisors to voluntarily consult on development of a future plan for art in the airport. The Airport Authority recently accepted the mission statement of the art committee: To manage an art collection of style, diversity and beauty to be enjoyed by our traveling public and employees which promotes public art and enhances the airport environment.
Companies interested in advertising opportunities at Pittsburgh International Airport should contact JC Decaux at 703-741-0114. Regional asset organizations interested in showcasing the region at Pittsburgh International Airport should contact JoAnn Jenny, Director, Communications, at 412-472-3517 firstname.lastname@example.com.


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What's New in OUM 5.6: Updated Manage Homepage
By Lauren Clark-Oracle on Jan 08, 2013
Have you seen the updated Manage Focus Area homepage in the latest release of OUM? If you have downloaded the recently released OUM 5.6, you may have noticed the Manage homepage was redesigned so that the primary navigation is now by activity, rather than by process as in prior releases. This was done based on feedback from our global PM community that they prefer to view and manage their projects at the activity level. The new activity diagram navigation allows a PM to see the major blocks of work that must be accomplished by phase. This enhancement provides a flexible checklist and high-level perspective preferred by many OUM project management practitioners.
If you still want to navigate through Manage via the process view (aka the Whale Diagram), you still can. Go to the bottom of the 'Select a View' list from the OUM homepage and select 'Full Method and Focus Areas'. On this page, you can then select the both the primary Manage view or the Manage Process view.
Haven't downloaded OUM 5.6 yet? Check out the official announcement for more information about how you can download the method pack and start taking advantage of the updates in OUM 5.6. In the meantime, your comments and feedback are very welcome.


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from the Illinois Board of Higher Education
July 8, 1998
Contact: Ross Hodel, 217/782-2551
New Century Planning Initiative Launched for Higher Education
HOFFMAN ESTATES - The Illinois Board of Higher Education has launched a major planning initiative designed to carry colleges and universities into a new century with a Citizens Agenda that focuses on the consumers of higher education - students, employers, and taxpayers.
The Board voted without dissent Tuesday to embrace eight strategic goals proposed by Executive Director Keith Sanders as the first step in a process to engage a broad range of citizen involvement in preparing a new century agenda for the state's colleges and universities.
"This is very much a work in progress," Sanders told the Board in introducing the plan. "It contains some old friends such as access, affordability, underrepresented groups, quality, and productivity, and some new ideas elevated to the status of important strategic goals, such as educational attainment, responsiveness of institutions to consumers, and strengthening the relationship with our K-12 colleagues."
The Board's action Tuesday formally set in motion a series of surveys and other mechanisms to measure satisfaction with colleges and universities and their graduates and to identify the most pressing needs of students and employers and ways higher education can help meet them. Surveys will be conducted of graduating seniors, employers, the general public, and opinion leaders.
To get the dialogue started, Sanders set forth eight preliminary strategic goals:
Using evidence showing that higher levels of education result in greater economic and social prosperity, the preliminary plan urges efforts to increase the number of people who graduate from high school and who obtain post-secondary degrees.
The plan proposes to expand access to a college degree for those who may be at a stage in life where they seek to return to school to upgrade skills or to further job opportunities, as well as to place-bound students for whom geography is a barrier.
Sanders' proposal suggests that cost should not prevent Illinoisans from gaining a college degree.
Demographic trends show that minorities will make up an increasing proportion of state's population, and the strategic plan recommends renewed efforts to promote greater enrollments of underrepresented groups and their success in college.
Sanders has urged that higher education hold its students to higher expectations, supply the help students need to reach those expectations, test them for their performance in meeting the standards, and use the results of assessments to improve curricula and instruction.
The proposal suggests that colleges and universities must respond to the changing needs of students and employers with targeted, cost-effective programs that are tailored to new market conditions.
Because the success of students in college is rooted in their schooling from kindergarten through high school, Sanders' proposal urges a stronger partnership between colleges and universities and elementary and secondary schools. Noting that the need for remediation at the college level is a symptom of poor academic preparation, the plan states that colleges and universities share responsibility for the performance and success of students at all levels of education.
Colleges and universities have made significant strides in improving productivity during the 1990s through the Priorities, Quality, and Productivity Initiative. Sanders calls upon them to build on those gains to help ensure adequate resources are available for higher education's most valued priorities.
Board members suggested they want the ultimate plan to be a forceful expression of an agenda that will serve the public. "I don't want the document to be watered down to please everybody," Board Chairman Jerry D. Blakemore said. And Board member Robert English urged that the plan take on a sharper focus as it is developed into an agenda "that will be the Board's mantra."
Sanders said the Board would not act on a final Citizens Agenda until December, "so we have time for a long and thoughtful discussion of these strategic goals." In addition to commissioning opinion surveys, the Board will engage business leaders, civic organizations, representatives and trustees from public and private colleges and universities, advisory groups, and others in critiquing, analyzing, and refining the Citizens Agenda initiative.


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A police perimeter in the Stoughton area delayed some students from getting home from school Monday afternoon.
Dane County sheriff's deputies were called to check the welfare of a man in a home in the 1900 block of Skyline Drive, near Highway 51 and County Highway B, just after 2:15 p.m. Monday.
Deputies said that when they arrived they thought they heard a gunshot, so they shut down the road, forcing a school bus to not let students off at their homes.
About two hours later, deputies went inside and found an intoxicated man but no firearms. The man was taken into custody.


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How do I remove infected content in archive files
The On-demand scanner in will detect and remove malware within archives. You may also use the Command line scanner to remove infected content from archive files.
nvcc /ald /u /c /cl:2
The various options and a short explanation will be listed if you run nvcc /?
The Command line scanner will use the On-demand scanner configuration setting unless overridden by command line options.
For example will nvcc /L:2 produce a detailed log file even though the On-demand scanner log file settings is set to Log infections and errors only.


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Torah, Bagels & Coffee
Subscribe To our E-Newsletter
Rabbi Howard Bogot begins a new series: Revelation: Dictation, Inspiration or Intuition?
Conversational theism, inspiration, tribal survival, caprice and intuition are all descriptions that could profile the role of revelation as the origin of Judaism. Did God "speak" to Moses? Do moderns receive divine messages? Is revelation complete or progressive? Are Jews chosen or choosing? Seminar participants will consider the components that are hallmarks of the narrated moment in which the Jewish people received Torah.
runs, Wednesday, May 7, and 14
Subscribe To our E-Newsletter


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Berlin board punts ambulance decision
BERLIN The high-stakes battle for Berlins ambulance business remains unresolved after the Select Board refused to declare a winner this week and took the matter under advisement for the second time in less than a month.
After listening to brief presentations from two of the bidders and quizzing the third at length, board members agreed they werent ready to decide between essentially maintaining business as usual and fueling the birth of a new ambulance service.
Id certainly like to digest the information for a while, Selectman Pete Kelley said after listening to presentations from the towns current ambulance provider as well as the Berlin Volunteer Fire Department and the man behind an intriguing no-cost offer that dominated discussion Monday night.
Board members unanimously tabled action on the matter until their April 1 meeting. A decision is expected at that time.
Though the board was presented with three detailed ambulance proposals last month, one is arguably on life support after voters recently rejected the Fire Departments request for $180,000 in supplemental funding to cover the cost of continuously staffing its Four Corners station. Without that extra money, department officials told the board, the per-capita price of starting a local ambulance service would more than triple from the $28 they had hoped to the $89 they had feared.
In a town with roughly 2,800 residents, that would turn what would have been a manageable first-year investment of $80,000 into a $250,000 start-up expense.
Deputy Fire Chief Scott Bagg acknowledged Plan B wasnt as financially palatable as he and others had hoped, though he defended the idea of creating a dual fire and ambulance department that could provide round-the-clock coverage to the community.
In something of a surprise, Bagg offered the departments qualified endorsement of one of the other two bidders, Barre Town Emergency Medical Services.
If we arent selected we strongly support Barre Town, Bagg said of the standalone ambulance service that has served Berlin without interruption since 1996.
Bagg stressed the Fire Departments renewed interest in breaking into the ambulance business was not a reflection of the quality of the paramedic-level service that Barre Town has provided over the years.
BTEMS Director Dave Jennings told board members that his service is interested in keeping Berlin as a customer after its current contract expires June 30.
Jennings said the service, which is run by Barre Town, has a proven track record in Barre Town, Berlin and beyond.
According to the three-year contract proposed by BTEMS, the annual per-capita fee would start at $26 and increase 5 percent a year over the life of the agreement.
The proposed contract includes an option for two additional years with annual increases of 3 percent. If Berlin were to exercise that option, the annual per-capita fee would be $30.41 starting July 1, 2017.
The board spent little time discussing the ambulance service that is a known commodity in the community and most of its time questioning the man who has offered to provide ambulance service to Berlin free of charge, while cutting the town in on 5 percent of the profit.
Matt George has pitched Central Vermont Emergency Medical Services as a public-private partnership that would allow Berlin to cash in on the fact that it is home to a regional hospital and two major nursing homes.
Berlin is in a tremendously unique position where you guys have the highest concentration of health care facilities in the state, said George, who is the clinical services coordinator for White River Valley Ambulance.
According to him, the combination of a comparatively low number of 911 emergency calls from residents and the unusually high volume of inter-facility transfers made Berlin an attractive target for a private ambulance service.
Georges observation was supported by Charlie Maymon, an executive for a privately owned Scandinavian-based company that is the largest provider of emergency medical services in the world.
Maymon said George recently approached Falck Ambulance, which does business in 37 countries on five continents, about the possibility of investing in CVEMS.
Though Maymon said Falck hasnt made any commitments, he said the type of service George had described was doable in Berlin.
Where you sit geographically is a great location for an ambulance service that is willing to reach outside of the town of Berlin and do other inter-facility work, he said, suggesting the service could turn a profit without charging the town.
Although George said his preference would be to work with Falck due to that companys depth of resources, he said he has lined up bank financing to buy two ambulances and establish an ambulance service by July 1.
However, George acknowledged those plans are in a holding pattern pending the towns decision. The board questioned him about plans to equip, staff and license the ambulance service he has proposed.
George said all could be accomplished within an ever-shrinking window and, while he has made progress on some fronts, he needs a definitive answer from the board before locking anything down.
david.delcore @timesargus.comMORE IN Central VermontStudents harming teachers is a little-explored issue at the state level. Full StoryThe state will get support in defending its end-of-life choice law, which several religious... Full StoryVermonts largest and smallest summer theater companies are the first to announce their 2017... Full Story
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I got so many great hair care tips and secrets from our giveaway entries, here are a few of my favourites...
* Almond Oil as a Treatment is Amazing. It Nourishes Hair and Brings Back your Shine . Just apply it to your Hair and put a Warm Towel around it for 30 Minutes then Rinse as usual.
* avocado oil and egg
* baby powder on oily roots
* using a treatment as conditioner
We also have the name of our lucky winner for the $50 voucher for Priceline... Congratulations Ashleigh Holden!!!
Thank you to everyone that entered!


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Doing a World of Good
Earth Day was founded by San José State alumnus and U.S. Senator Gaylord Nelson. His proposal gathered 20 million Americans to celebrate the first Earth Day on April 22, 1970.
43 years later, the CSU continues its strong commitment to the environment by encouraging sustainable practice and global thinking. More.
Student Research Roundup
For CSU students, time in the lab is just a part of the undergraduate learning experience.
In recognition of National Undergraduate Research Week April 15-19, CSU Leader highlights some of the student breakthroughs that are earning grants and getting some serious attention from the scientific community. More.
Building a Better World
The National Campus Compact recently recognized a select group of college students who are creating lasting change in their communities. Four of the nine students selected from California attend a CSU campus. More.
CSU Police Dominate in the Desert
Every spring, law enforcement officers from around the world compete in the "largest police foot pursuit in the world," a grueling 120 mile relay race that begins in Baker, California and ends in Las Vegas, Nevada. This year, the CSU Police Team took top honors. More.
San José State and EdX Expand Collaboration
Thousands more CSU students will benefit from SJSU's collaboration with edX, founded by Harvard and MIT. More.
Anne Frank Tree Planted at Sonoma State
Sonoma State planted a sapling from the tree that inspired Holocaust diarist Anne Frank, one of only 11 saved when the tree was set to be destroyed. More.
CSUN Awarded $1.5 Million for Math Program
CSU Northridge received a $1.5 million grant from the National Science Foundation to spearhead a program designed to help students pursue advanced degrees in math. More.
CSUMB Gets Electric Vehicle Charging Station
CSU Monterey Bay has installed two electric vehicle charging stations on campus that are accessible to the community. More.
Fresno State Gets Pistachio Research Endowment
The California Pistachio Research Board pledged $1.5 million to establish an endowed faculty position with Fresno State's Jordan College of Agricultural Sciences and Technology. More.
To get to know the students, faculty, staff and communities that make up the CSU, Chancellor Timothy P. White is visiting all 23 campuses during his first year.
Last week, he learned about the people and programs at Humboldt State. Find out more about the experience here.
For questions, e-mail Mike Uhlenkamp.
Review past issues at the CSU Leader
Subscription Information: To subscribe or unsubscribe to CSU Leader please visit the CSU Leader homepage.


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Headlines (Notices)
Faculty of Science
Laurier hosts SHARCNET 10th Anniversary Research Symposium
Communications, Public Affairs & Marketing
Nov 7/11
Laurier will host a research symposium on its Waterloo campus Nov. 17 to mark the 10th anniversary of SHARCNET (the Shared Hierarchical Academic Research Computing Network). Laurier is one of the founding members of the organization, which brings high performance computing to researchers at 17 academic partners in Ontario.
Three Laurier researchers who use SHARCNET Ian Hamilton, Shohini Ghose and Jacek Miloszewski will discuss some of their interesting work, and Hugh Couchman, SHARCNETs scientific director, will give an overview of SHARCNETs past and future.
Date: November 17, 2011
Time: 8:45 11:45 a.m.
Location: CC-101 (Career Development Centre, King and Lodge Streets, Waterloo)
Cost: Free
All are welcome. Coffee and refreshments will be served.
For more information, please visit: http://www.wlu.ca/events_detail.php?grp_id=1&ev_id=8822


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Almighty and everlasting God, who in the Paschal mystery established the new covenant of reconciliation: Grant that all who have been reborn into the fellowship of Christ's Body may show forth in their lives what they profess by their faith; through Jesus Christ our Lord, who lives and reigns with you and the Holy Spirit, one God, now and forever. Amen.
The Response: Psalm 118:14-29 was led by David Maitland. *(verse 29) "Give thanks to the Lord, for he is good; his mercy endures forever.
The First Reading was read by Arthur Clark: Acts 5:27-32. After Jesus' death the high priest questioned the disciple's teachings about the crucifixion of Jesus and blaming the Jews. Peter answered him saying that all they teach is true and they must obey God. They were witnesses of all that happened and God gives the Holy Spirit to all who obey him.
The Second Reading was read by John Greve from Revelation 1:4-8. John, author of Revelation, records that Christ will come again with the clouds and every eye will see him. "I am the Alpha and the Omega," says the Lord God who is and who was and who is to come, the Almighty.
Reverend Abernathy read the Gospel of John 20:19-31. This is the account of Jesus appearing to the disciples the first day of the week after his death. He had entered a locked room where they were meeting and astonished them. After Jesus showed them his hands and side wound, he breathed the Holy Spirit upon them. Later they told Thomas who was absent that day and he would not believe them unless he saw it with his own eyes. A week later Jesus appeared to them again, and this time Thomas was there and believed Jesus was the Lord and alive. Jesus told them that in the future others must believe on faith for they would not be able to see him. The disciples were told that they must spread the news to the world. There were also other signs in their presence that are not recorded in the book, but Jesus wants everyone to know that he is the Messiah so you can believe in him and have life everlasting.
Reverend Abernathy discussed the fact that Jesus' life is recorded by different authors who have different points of views in telling the story of Jesus. Though some little details may be different, the basic story of Jesus is the same. He is the Son of God, the Messiah, who came to save the world from sin. By reading all the Gospels we have a composite account.
Jesus appeared to his disciples and breathed the Holy Spirit upon them, for he would soon be leaving them to go to his Father. By doing this Jesus commissioned the disciples to continue his work on earth in taking the Good News to everyone. They had been witnesses of his being there after the crucifixion. No one had witnessed the resurrection, only that Jesus was alive again after being placed in a tomb. Obviously something happened on Easter, for why has the Church continued going on so long after his death. Christ has been studied worldwide and is still believed in to this day. His resurrection was the raising from death to an entirely new order of existence. Believers will be able to experience the same phenomenon some day and be with Christ in his kingdom. Our greatest evidence is that the Church still exists. Everywhere there are churches that worship Christ because God raised him from the dead and made him Lord and Christ.
That is what happened at Easter.
Wednesday evening at 6 p.m. there will be a Bible Study and light super. The study will be led by Reverend Gooch. All are welcome to come. Next Sunday at 9 a.m. Reverend Gina Frnka will be the pastor at the service.
PIM web site.


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Press release - AB Volvo
AB Volvo hereby invites the media to a press conference on February 6 2013 in conjunction with the release of the Volvo Group full year report for 2012. The press conference will take place 09:00 at Tändstickspalatset in Stockholm.
Press conference, 09:00 AM CET
The press conference will begin at 09.00 AM CET and will be held at Tändstickspalatset,
V Trädgårdsgatan 15 in Stockholm.
Please note that the report is scheduled to be released at 7.20 AM CET February 6. President and CEO Olof Persson will participate in the press conference. For those who wish to participate and ask questions by telephone in the press conference, please call +46 8 505 598 53 (Sweden) or +44 (0) 203 043 24 36 (UK) about five minutes prior to the start. The press conference will be webcasted on http://www.volvogroup.com/ and http://www.volvokoncernen.se/.
Conference call for investors and analysts, 2.30 PM CET
To participate in the conference, call +46 8 505 598 53 (Sweden), +44 (0) 203 043 24 36 (UK) or +1 866 458 40 87 (US). The conference will also be broadcasted live at www.volvogroup.com/investors, where presentation material will be available for downloading and the tele conference will be available for replay.
Follow us on Twitter: https://twitter.com/VolvoGroup Hashtag: #VolvoQ4
January 23, 2013
Reporters who want more information, please contact: Kina Wileke, Media Relations Volvo Group, +46 31 66 12 32


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"Catholic Answers Live has been there for me, through God's infinite wisdom, and oftentimes answered questions I had been thinking about myself. Your radio program has been very instrumental in my conversion to the Catholic Faith."
~ Ross, Portland, Oregon
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"Holy Father, now I believe."
~ Bishop Edward Fitzgerald of Little Rock, Arkansas; one of only two bishops at Vatican Council I who had opposed the definition of papal infallibility in the final vote; publicly acknowledging his acceptance of the truth thus defined.


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Cost of 1st year of college
Published On: Sep 09 2013 12:00:00 AM CDT
College is expensive, but just how much will it actually cost? Find out how much you can expect to spend during your first year of college.
The views expressed are not those of this company or its affiliated companies. By posting your comments you agree to our Terms of Use.


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What is in this article?:
- Dry weather delays cotton planting
- Could lead to problems
Nearing the mid-May mark, University of Georgia Extension Cotton Specialist Guy Collins said his growers were about 20 percent planted, compared to a five-year average of 25 percent.
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In what should been one of the busiest planting times of the year, cotton seed remained in the sack in many parts of the lower Southeast as unseasonably hot, dry weather lingered over the region during the first half of May.
Nearing the mid-May mark, University of Georgia Extension Cotton Specialist Guy Collins said his growers were about 20 percent planted, compared to a five-year average of 25 percent.
"We're in a holding pattern for planting cotton now, especially our dryland producers. I don't think we can say yet that this crop is late, but we can't afford another two weeks of hot, dry conditions. We're just a little bit behind right now, and we're certainly not in a panic situation," says Collins.
Some see June 1 as the latest a grower can plant cotton and expect good results, but Collins sees some flexibility to that rule.
"With some of the earlier varieties, I don't think June 15 would be out of the question as a planting date," he says.
Collins estimates that anywhere from 45 to 50 percent of Georgia's cotton is irrigated.
The most challenging planting decisions during the early part of the planting window are often associated with dryland acreage, says Collins. When warm temperatures prevail, growers usually begin planting dryland acreage as soon as sufficient soil moisture is available.
Since this year has been relatively dry so far, several growers have been faced with decisions of whether to "dust in" seed in anticipation of rain if soils are extremely dry, plant deeper to capture some sub-surface moisture, or to delay planting until it rains.
Of course, says Collins, there is a risk that it will continue to remain relatively dry which could force growers to plant in sub-optimal conditions.
According to University of Georgia recommendations, deeper planted cotton should be planted at depths between 0.75 and 1.25 inches but not greater than 1.25 inches. Planting on the shallower end of this spectrum is advised when encountering unfavorable soil or environmental conditions, or if surface crusting is likely.


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Bellydance by Alexandra
- Serving:
- Serving Miami FL
- Address:
- 1431 alton rd
- City, Zip Code & State
- miami beach, FL 33139
Bellydance by Alexandra offers bally dancing entertainment for all your events in and around the Miami FL area.
Bellydance by Alexandra
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The performances incorporate modern and classical styles of bellydance with a variety of exciting props to choose from, such as fan veils, isis wings, candelabra (using real lit candles), sword, cane, silk veils and finger cymbals.
MIDDLE EASTERN THEMES or BACKGROUNDS
The shows can be custom made to amodate a particular Middle Eastern background of the guests or a themed events. (Lebanese, Israeli, Egyptian, Moroccan, Turkish, Greek, etc.)
Alexandra wears only top of the line beautiful AUTHENTIC costumes beaded with rhinestones, crystals using the finest fabrics. Color themes can be matched to your event. She will normally wear the classical two piece costume, but if a full covered dress if desired, just let her know!
SHORT MINI SHOW OR BELLYGRAM (10 15 minutes)
This package can consist of a performance with and entrance with one or two props and a short audience participation session. This choice is ideal as a surprise for birthdays, restaurants, offices and for parties where multiple entertainers are performing.
CLASSIC BELLY DANCE ROUTINE (25 30 minutes)
The show consist of a grand entrance using props such as veils, Isis wings or candelabra then it will continue with finger cymbals, sword or cane and the will finish of with audience participation. This choice is perfect for weddings, corporate events, theme parties or family celebrations or to get any party started!
MINI CLASS PARTYBO (1 hour)
This is the PERFECT option to create unique women-only events such as bachelorette parties, baby showers, bridals showers, etc. This option includes a mini-performance (15 minutes) followed by a 45 minute belly dance class. Loaner coin belts (or for sale) as available upon request.
Contact me to receive a quote, Prices change depending on the location and the lenght of the performance.
For More Information Please Call
OR VIsit: bellydancebyalexandra
Among other cities, Bellydance by Alexandra may serve the following areas: Miami, Fort Lauderdale, West Palm Beach, Fort Pierce, Hollywood, Pompano Beach, Pembroke Pines, Boca Raton, Davie, Plantation, Sunrise, Coral Gables, Hialeah, Kendall, Homestead, Oakland Park, South Miami, Delray Beach, Lake Worth, North Miami Beach, Port Saint Lucie, Boynton Beach, Coral Springs, Miami Beach, North Miami, Perrine, Tamarac, Deerfield Beach, Miami Shores, Olympia Heights
Alexandra Lenis – Middle Eastern Dance Artist
Alexandra has been dancing and teaching in South Florida as well as internationally for over 10 years. She has traveled extensively to learn the dance and culture of the Middle East, including places such as Egypt, Turkey and Morocco. She has performed as special guest artist in various dance productions and dance festivals locally and internationally including faraway places such as China. The theatre performances include numerous performances with the Mid Eastern Dance Exchange, (a non-profit organization) as well as in several of the renown "Orientalia" dance festivals (2003, 2004, 2005 and 2009) and was part of the legendary Emerald Dreams Dance Company under the direction of internationally acclaimed interpretative Middle Eastern dancer and published author Tamalyn Dallal. In 2005, together with Ms. Dallal, she organized an educational dance retreat in Siwa, Egypt. (A desert oasis in the Sahara desert) Alexandra has also been featured performing in National TV networks and media like Telemundo, Univision, MegaTV and the Miami Herald.
Her favorite style being Egyptian, has inspired her to study with Egyptian dance legends such as Raquia Hassan, Dina, Yousry Sharif, Mahmoud Reda just to name a few. Her strong technique and knowledge allows her to teach students from beginner to advance and professional level. Her teaching style is precise and easy to follow focused on posture and polishing the fundamental steps of the dance to allow students to create their own style. She currently owns and directs the Art of Bellydance Studio and Performance Space; a dance school dedicated to educate, inspire and diffuse this ancient art form and other Middle Eastern dances.
OR VIsit: www.bellydancebyalexandra.com
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"I started listening to Catholic Answers Live when I was struck down by an illness that basically left me bedridden. This left me questioning my faith and mortality, and my son introduced the Catholic Answers Live podcast to me. Listening to all the guests explain and defend the Catholic Faith has been instrumental. Has Catholic Answers made a difference in my life? It has become part of my life!"
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"In the week immediately before Lent everyone shall go to his confessor and confess his deeds and the confessor shall so shrive him as he then may hear by his deeds what he is to do [in the way of penance]."
~ Anglo-Saxon "Ecclesiastical Institutes" translated from Theodulphus by Abbot Aelfric about A.D. 1000; explaining the English term "shrovetide" (from "to shrive", or hear confessions) wherein the religious idea is uppermost; but before long, human nature allowed itself some exceptional licence.


text: My 16 mo is still an all night nurser. I still nurse him to sleep and really enjoy doing it. I don't enjoy being awaken ever hour just after I seem to get comfortable. I have been trying for the last week to refuse nursing from 12 am to 4 am(read that somewhere else). He is still waking up and is really angry. My husband isn't home every night so can't really take over plus he can be a very deep sleeper so we aren't comfortable enough leaving him alone at night to cry it with dad. We have always done reverse cycle feeding since I have to work full time. But he eats great and really only nurses for comfort and habit. I want to minimize the trauma but I need to make a change. We would like to try for another soon and I know it can limit my fertility plus I just want to sleep. Any suggestions?