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Imperial Purple Earring
Style: 570096357
Out of Stock
A jeweled play of delicious shade of winter's Imperial purple in one sparkling earring.
- Stainless steel post. Just over 1" drop.
- Smooth and faceted glass and Czech glass stones. Polished hematite setting.
- Custom designed exclusively for WHBM. Handcrafted with nickel-free and lead-free metal.
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[Today: A much richer soundtrack…]
At their core, soundtracks are really just big budget mix tapes, designed to set a mood. In my opinion, the very best among them is Rushmore, an album that checks every box on the soundtrack wish list: its whole is much greater than the sum of its parts, it blends together seamlessly, and (most critically) it's full of great songs you either hadn't heard or hadn't paid much attention to before. Assembled by director Wes Anderson and Devo founder Mark Mothersbaugh, Rushmore is a 56-minute master class on how to put together a killer mix tape.
The movie Rushmore is about a teenager named Max who has more smarts than common sense, and his interactions with the hyper-interesting people around him. The opening credits – a montage of the various high school clubs Max belongs to, including the Beekeeper's Club – cracked me up because I helped found Springfield High's first (and only) Peace Club. Like Max, I was a smart-alecky, love sick kid who didn't have the slightest idea where he was going in life.
This soundtrack sets that mood perfectly, with a collection of British Invasion bands like The Kinks, The Who, and The Faces, along with forgotten gems by the likes of The Creation, Chad & Jeremy, Unit 4+2 and Cat Stevens, as well as offbeat additions by French chanteur Yves Montand and jazz saxophonist Zoot Sims. The whole thing is stitched together by short, upbeat yet baroque instrumentals created by Mothersbaugh on glockenspiel.
Wes Anderson originally envisioned the soundtrack as nothing but Kinks' songs before coming around to the eclectic selections that eventually informed this album. That was a very good decision. When asked about working with Anderson, Mothersbaugh replied that "He makes great choices. He's really into music. He's interested in B-sides, things besides the hits. It makes for a much richer soundtrack than if you just make a deal with the record company about what they will give you."
Rushmore is the opposite of a big-budget, paint-by-numbers Hollywood soundtrack. Anderson and Mothersbaugh's soundtrack feels like it was built by hand, with loving care, from a great record collection. It's an outstanding musical journey through the minefield of adolescence, and it gets my vote for the best soundtrack of all-time…
Listen: Concrete & Clay [Unit 4+2]
Listen: Here Comes My Baby [Cat Stevens]
Listen: Ooh La La [The Faces]
Further reading: The 20 Greatest Soundtracks Of All-Time

subset: commoncrawl


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A new way to experience space travel could be coming to New Mexico.
Company promoting space travel by balloon
Published On: Dec 16 2013 07:16:27 AM HST Updated On: Apr 30 2014 08:54:29 AM HST
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Cramer's 'Mad Money' Recap: Looking for Real Leaders
NEW YORK (TheStreet) -- This market needs leadership, but not reckless leadership, Jim Cramer cautioned his "Mad Money" TV show viewers Thursday. He said now is the time when investors need to stay focused because the markets may now be due for a pause.
Cramer explained that the market's big move in recent weeks started off well enough, with high-yielding dividend stocks leading the way. Those stocks were followed by the food, drug and beverage names, also great companies. Then the transports and technology names rallied, he said, followed most recently by the industrials, oils and mineral stocks. That was all well and good, until yesterday.
Yesterday and today saw big moves in Micron Technology
Other stocks with huge moves included Tesla
Cramer said it's certainly possible to be intellectually right on names like these while at the same time being practically wrong -- as many of the shorts found themselves over the past two days -- but moves likes these seem "frothy" he said, and could be indicative of an imminent pullback.
"This market needs to cool down," Cramer concluded, or these moves simply won't last.
Executive Decision: Joseph Papa
In the "Executive Decision" segment, Cramer sat down with Joseph Papa, chairman and CEO of Perrigo
Papa said he's excited about his company's 18% growth in the quarter, along with its 20% growth in its health-care product division. He said Perrigo's entrance into pet care products has been a big win for consumers, retailers and his company, with Perrigo products now available in our country's largest pet care chain, PetSmart


text: The three artists Ayşe Erkmen (born, 1949), Ceal Floyer (born, 1968) and David Lamelas (born, 1946) are united by an artistic approach that follow a reduced grammar of form. Their individual handling of time and space, their preoccupations with limits and possibilities for the creation of alternative communications and cognitive processes has been the motive of this group exhibition. The exhibition title Above – the – Fold[1] refers to an artistic strategy, for the creation of works, in which the surface structures, on the one hand, follow the semantics of the exhibition space and transform it, and on the other, refer beyond their own form to contexts, which often only become legible in the works' subtexts.


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Watch: A pint-sized Natalie Portman and fresh-faced Rachel McAdams rock their audition tapes. BRB while we watch The Notebook (for the millionth time).
Know: Kate Moss's documentary debuts in France on January 12. No word on when it will cross the pond, but we're hoping for deets on her relationship with Johnny Depp.
Find Out: What the highest-grossing films of 2013 all had in common. Hint: Some serious girl power was involved.
See: Kaley Cuoco's pink Vera Wang wedding dress. Let the "Dream Wedding" pins commence.
Tell us what you're buzzing about this week, or tweet us at @ruelala.
Not a Member and like The (Style) Guide? You'll love Rue La La. Join now.


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Code Violations 621-84001. Car Parked On Lawn2. InOp In Driveway (cob webs, flat tires, wrecked)3. InOp In Yard4. Car Over Unpaved Surface5. Boat Stored In Driveway6. Trailer Stored In Driveway7. Trailer Stored In Yard8. Boat Stored In Yard9. Tall Weeds, 6" Tall10. Dry, Tall Weeds11. Vacant Unsecured House12. Trash In Yard13. Trash In Driveway14. Trash At Gutter15. Junk And Appliances In Driveway16. Junk And Appliances In Yard17. Canopy In Driveway18. Basketball Hoop On Sidewalk19. Parked Car On Sidewalk20. Trash And Junk In Alley21. Weeds, Dry, Tall In Alley22. Auto Repair On Property23. A Fence Taller Than 6 Feet Or Shorter Than 3 Feet24. Mobil Home In Driveway25. Mobil Home In Yard26. Yard Sale Signs on Trees, in Medians, or on Poles
Police Violations 621-8000
1. Boat Stored In Street2. Trailer Stored In Street3. Basketball Hoop In Street4. Mobil Home Parked In Street W/Power Hooked Up
Public Works 621-8650
1. InOp Parked In Street (cob webs, flat tires, wrecked)2. Sign Replacement/Repair3. Sidewalk, Curb, Gutter Repairs4. Tree Removal/Replacement And Trimming5. Street Lights6. Traffic Lights7. Standing Water
Community Sanitation Graffiti Reporting Form On-Line
1. Graffiti Reporting (fences, trees, parks, building and signs)


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"Try going to the movies or taking a special outing," Cohen said.
Some families create a chart to map goals, then at certain points along the way the rewards are granted.
"A trip to favorite place ... or something they value but don't get a chance to do often. Be creative," suggests HealthyEatingAdvisor.com.
Rewards could include a day at a water park, a sleepover with friends or something small such as a book, a temporary tattoo, a puzzle or gift certificate to a favorite store.
Exercise Goes Beyond Gym
Don't forget, exercise comes in many forms.
"When most adults think about exercise, they imagine working out in the gym on a treadmill or lifting weights," according to KidsHealth.org. "But for children, exercise means playing and being physically active. Kids exercise when they have gym class at school, soccer practice or dance class. They're also exercising when they're at recess, riding bikes or playing tag."
Cohen said 30 minutes of cardiovascular activity three times a week is a good target for which to aim. And families should keep daily screen time to less than an hour a day on school days, whether that means videogames, TV or non-school-related computer surfing.
While a family can initiate its own fitness program, Cohen recommends seeing a doctor before you start. In his practice, Cohen asks questions to get a complete picture of the family's overall health, and runs screening tests on the children that may pick up hidden problems.
A doctor can help a family tailor its fitness regimen to address any problems. The benefits are substantial and cumulative, and can help increase life expectancy and lower the chance of heart disease.
"Increased physical activity has been associated with an increased life expectancy and decreased risk of cardiovascular disease," according to the American Heart Association. "Physical activity produces overall physical, psychological and social benefits. Inactive children are likely to become inactive adults. And physical activity helps with controlling weight, reducing blood pressure, raising HDL ("good") cholesterol and reducing the risk of diabetes and some kinds of cancer."


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Guns in the Sun
Editor-in-Chief, VICE
The original version of this article appeared in the print edition of VICE's December Hopelessness Issue. It was sent to press two weeks before Friday's massacre in Newtown, Connecticut – one that ripped the heart straight out of America's chest. An unfortunately timely piece, it has been updated accordingly.
The almost unfathomable national tragedy that happened on December 14th in Newtown, Connecticut was the latest and most horrific example in a string of mass shootings that have occurred in the United States over the past 30 years. Unfortunately it took the brutal murder of 20 very young students and six of their caretakers at Sandy Hook Elementary School for Americans to truly attempt to wrap their minds around current firearms laws and reflect on the culture that has created them. And this time there will almost certainly be a massive legislative shift on the national level. How pivotal it will be remains to be seen.
However, what the nation will find – if history is any indicator – is that legal solutions to this dilemma will prove unsuccessful. Even worse, further restrictions on firearms may exacerbate the situation. This is because the information and decision-making process that is needed to responsibly unify firearms laws is inherently flawed from within.
There is a very specific reason that people – heroes, monsters and especially Americans – like guns. It's the same reason I like guns. I like shooting down a pockmarked range or sandy berm on a cloudy day. I like the feeling of curved metal behind my fingertip, knowing that the world can be forever changed with a simple pull.
My more sensible friends tell me I am this way because I'm a Floridian. And up until recently, I pretended to disagree. But I can no longer deny that they've been right all along. Then again, my most sensible friends were not born in Florida.
Growing up in the Sunshine State, I was brought up around guns and taught to respect their power, ensuring that I accepted the full spectrum of responsibility that comes with owning or even holding a firearm. Many of the people who raised me (with the important exception of my mother) felt that it was their duty to teach me the basics of gun safety, in the same way everyone should know how to fix a flat tire. This does not mean I agree with all or even the majority of American firearms laws. And in order to delve into the minutia of one of the most troubling catch-22s of our time, in mid-November I waded through the swampy backwaters of firearms legislation in my home state, which I hoped would serve as a microcosm for the rest of the nation. I believe it served its purpose.
For starters, to the vehemently anti-gun among you, to gain some perspective on how we arrived at this seemingly unsolvable problem, I issue this challenge: put yourself in a place where your life or safety, or that of a loved one, is in grave danger. Then imagine that place is a sunny peninsula made up of hardworking citizens, self-reliant yet senile old folks, self-described "crackers" (Google the etymology of that one if you don't know it already), ultraviolent face-eating felons, disgustingly rich sociopaths, Miami-Dade County and the creepiest boiled-brain tweaker weirdos on Earth. Welcome to Florida, population 19 million. Based on my years of experience trolling around with, at turns, some of the most interesting, valiant and despicable residents of the state, I can assure you that many wholly sensible and productive Floridians of all stripes own guns. And yeah, a lot of scumbags have them, too, and they will shoot you without hesitation if they feel so inclined.
Decorated combat veteran and firearms enthusiast Eddie Cacciola stands in front of an American flag signed by fellow Marines who served with him in the first wave of Operation Iraqi Freedom.
One of the good guys is Philadelphia native Eddie Cacciola, a 32-year-old former Marine. Eddie moved to Florida five years ago. Before that, he served as a decorated combat engineer – "like the guys in The Hurt Locker" – during the first wave of Operation Iraqi Freedom.
Eddie joined the Marines on September 18th, 2001. He was already considering enlisting, but 9/11 made the decision for him. He quit his dream job of running a motorcycle-racing team and importing MVs, Ducatis and other high-end exotic bikes to fight in Iraq.
In 2005, Eddie returned from duty to Philadelphia and grew steadily more disenchanted with the War on Terror. "We maybe stuck around too long. People started not appreciating that we were there," he said as we drove to a local Walmart to buy cheap ammo. "It was kind of a letdown of something that I think started as a good thing."
Two years after his return to Philadelphia, Eddie moved to Sarasota, Florida, with his then girlfriend, who was from the area. The city's immaculate white-sand shores include Siesta Beach, rated the top beach in the US in 2011 by "America's Foremost Beach Expert," Dr Beach. It also happens to be my hometown, and I met Eddie through a mutual friend who knew I was planning to write a story from the perspective of responsible and thoughtful gun owners.
Eddie told me that, before his time in the Marines, he wasn't much of a "gun person". He had fired rifles and shotguns various times while living in Philadelphia, but after his return from Iraq he began to see guns more as tools of life and outlets for recreation. Like many of his fellow Floridians, he believes in the public's right to carry and bear arms pretty much wherever they choose. But while Eddie supports or is mostly indifferent to many of the state's gun laws, he does take issue with one.
"In Florida, you can go ahead and buy, sell and trade anything – as long as it's not an illegal weapon," he said. "You can just find somebody or something that you like, work out a deal with him, meet them in a local parking lot, do a third-grade trade with some money and a gun. Nothing else needed." Alaska, Arizona and Vermont are similarly lenient when it comes to these types of transactions.
Before my visit, a few weeks prior to the 2012 presidential election, I had asked Eddie whether he'd be willing to coordinate a trip out to the range with some of his shooting buddies. He happily obliged, with one caveat: "Get here quickly, because people are stockpiling. They think Obama might get elected again. If we wait too long it might be much harder to get ammo for certain weapons."
It was the same story propagated in 2008 following Obama's victory. Many firearms dealers in Florida and throughout the nation reported a massive uptick in background checks, which went from 11.2 million in 2007 to 12.7 million in 2008 – a clear indicator that gun sales were spiking. The stockpiling resulted in an ammo shortage that, by February 2009, left many owners frustrated because dealers simply could not keep up with the demand. That month, the Orlando Sentinel reported that 9mm and .45-calibre bullets for semi-automatic pistols and .38-calibre bullets for revolvers were becoming scarce, and that clerks at Walmarts in Apopka and Kissimmee had confirmed that the aforementioned types of ammo, along with .22-calibre bullets (one of the most common forms of ammunition), were on back order. Floridians, it seemed, were ready to rock 'n' roll.
This October, a month before the election, background checks for potential gun purchasers nationwide were up 18.4 percent since the same time last year and, just as in 2008, sales of assault rifles such as the AR-15 and AK-47 increased after Obama's victory. Many of the gun dealers and owners quoted in the press said they feared Obama would reinstitute the Federal Assault Weapons Ban, one of the most controversial aspects of the Violent Crime Control and Law Enforcement Act passed under Clinton in September 1994. The ban relied on a convoluted flowchart to determine which sorts of weapons and accessories were to be made illegal for purchase by the general public.
Thanks to sunset provisions, the law expired in 2004. Since then, lawmakers like Senator Dianne Feinstein of California and Congresswoman Carolyn McCarthy of New York have unsuccessfully attempted to reinstitute the ban. Studies conducted by the University of Pennsylvania, the Centres for Disease Control and Prevention and other independent studies found that the ban's effect on violent crimes had been small, if negligible. The Department of Justice's National Institute of Justice released a 2004 assessment of the decade-long ban, stating that if it were to be reinstated at a future date, its "effects on gun violence are likely to be small at best and perhaps too small for reliable measurement. [Assault weapons] were rarely used in gun crimes even before the ban." A dissenting study carried out by the Brady Center to Prevent Gun Violence alleged data provided by the ATF showed that the proportion of violent crimes in which assault weapons were used dropped from 4.82 to 1.61 percent during the ban. A spokesperson for the ATF later said that his organisation could "in no way vouch for the validity" of that claim.
While it's been perfectly legal for the past eight years to buy an AR-15 alongside a £120 aftermarket "bump-fire stock" (which effectively transforms it into a full-auto weapon), gun rights supporters have reason to be fearful of Obama reinstituting some iteration of the Assault Weapons Ban. Obama served as a senator in Illinois, home to what many say are the strictest gun laws in the country. Leading up to his first presidential election, he was cautious but outspoken regarding his opinion that certain types of weapons should not be available to the public. A 2009 Gallup poll reported that as many as 41 percent of Americans believed that Obama, at some point, would "attempt to ban the sale of guns in the United States while he is president" – as in, all guns. And this August, White House spokesperson Jay Carney told reporters that the president fully supported a renewal of the ban.
When prompted with a question about federal firearms laws during the second 2012 presidential debate, Obama said that part of his strategy to curb street violence in America "is seeing if we can get automatic weapons that kill folks in amazing numbers out of the hands of criminals and the mentally ill". This sort of reasoning doesn't seem to take into account the legal rights of responsible gun owners – hardworking and scrappy folks who fully believe that the right to bear arms is inalienable, at least in America. Regardless of whether a new ban happens or not, the hoarding has already begun.
Topics: Guns, Newtown, gun violence, gun control, mass killing, dead, 26 dead, Adam Lanza, depressing, sad, why, children, School, Matricide, Connecticut, shooting, fear, NRA, National Rifle Association, Gun Lobby, Background Checks, Gun, Gun Laws


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Chiffon Floral Dolman Sleeve Blouse
Style: 570088103
Out of Stock
Sheer dolman sleeves have an elegant drape on a chiffon floral top that brings Lotus teal into its color scheme. With a silky knit tank lining, the top blouses slightly at the hem.
- Pullover ease. Bloused silhouette.
- Self piping at the neckline.
- Attached silky knit lining.
- 100% Polyester. Machine wash. Imported.
- Hits at mid-hip (24.25" from shoulder).
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White House | Black Market and WORKKIT are registered trademarks of Chico's Brands Investments, Inc. © 2016 Chico's Distribution Services, LLC. All Rights Reserved.


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Nature shines in Morgan poetry collectionWritten by Gary Carden
- font size decrease font size increase font size
To see a world in a grain of sand,
And a heaven in a wild flower,
Hold infinity in the palm of your hand,
And eternity in an hour.
ŌĆö ŌĆ£Auguries of InnocenceŌĆØ by William Blake
The stanza above, from William BlakeŌĆÖs ŌĆ£Auguries of InnocenceŌĆØ serves as an apt introduction to Robert MorganŌĆÖs latest collection of poetry. Here, the reader will find a catalog of vivid images from the natural world: a spiderŌĆÖs web spangled with dew drops; mountain pools pierced by sun beams; a wind-blown thistle and the husk of a jar fly ŌĆö all transformed by MorganŌĆÖs elegant words ŌĆö words which have the power to render these images ŌĆ£numinousŌĆØ (possessing a religious or spiritual quality).
In conjunction with MorganŌĆÖs skill in capturing vibrant images is his ability to describe those images with magical language. For example, the title of this collection, Terroir, is a word (French in origin) used to denote the special characteristics that geography, geology and climate bestow upon crops and/or produce. Just as the quality of a vintage wine may be determined by the combined effects of a particular regionŌĆÖs rivers, the mineral content of the soil and the length of the growing season, Morgan suggests a parallel in the natural world of Appalachia. In effect, the inhabitants of the coves and ridges of the Southern Highlands are what they are because of the same factors. We (and all living things) are molded and shaped by the same forces that might render/produce something original ... a rare wine with its unique taste or a mountain family, surviving against all odds and steeped in tradition.
Terroir contains a number of recurring themes: rituals, folk beliefs, superstitions and the subtle and orderly design of the natural world.
ŌĆ£October CrossingŌĆØ celebrates the annual orange and black, woolly worm migration which, in mountain folklore will determine how hard the winter will be. However, in MorganŌĆÖs imaginative description, this events merges with classical mythology. The woolly worms migration must cross a highway ŌĆ£like a hard Styx or JordanŌĆØ to reach the refuge of the woods. In ŌĆ£Apple Howling,ŌĆØ there is a comparison of the Anglo-Saxon ŌĆ£come forthŌĆØ ritual in apple orchards (beseeching the trees to produce a generous crop), to the ŌĆ£come, butter, comeŌĆØ incantations that my own grandmother chanted to transform clabbered milk to butter. ŌĆ£Singing to the CornŌĆØ recounts yet another ritual to encourage fertility and ŌĆ£ImmuneŌĆØ celebrates an old superstition about going barefoot in the first snowfall as a means of preventing winter ailments.
Beneath all of these poems, like a quiet, but ever-present stream, is a series of affirmative verses regarding NatureŌĆÖs ŌĆ£silent design.ŌĆØ ŌĆ£Loaves and FishesŌĆØ celebrates the slow decay of a deer on the highway, noting the process by which every bit of flesh ŌĆ£is sorted, hauled/ away by scavenging coyotes,/ by maggots, worms, bacteria, /each bite sent to its proper place/ to feed the needy multitudes.ŌĆØ ŌĆ£TranslationŌĆØ finds a striking example of rebirth in the way that trees die ŌĆ£and lean into the arms/ of neighborsŌĆØ where they gradually disintegrate and ŌĆ£... eed the the roots/ of soaring youth.ŌĆØ
There are also frequent allusions to NatureŌĆÖs tendency to ŌĆ£mimicŌĆØ cosmic design. For example, the sprouts of potatoes struggling toward the light in ŌĆ£HomesicknessŌĆØ resembles genetic memory struggling ŌĆ£across the gulf of history.ŌĆØ In another poem, In ŌĆ£Country of the Sun,ŌĆØ Morgan finds a poignant parallel in the struggles of a neighbor stricken with an eye cancer who moves down a road in the sunlight of a spring day with the same yearning towards the light. In ŌĆ£The Big One,ŌĆØ the explosion of seeds from a winter thistle resembles that outward rush of matter that created the universe. Again, in ŌĆ£Lone Eagle,ŌĆØ the fall of snow flakes in a pine forest suggests ŌĆ£a ticker tape paradeŌĆØ witnessed by ŌĆ£snow bird, mouse and solo wren.ŌĆØ The spiraling flight of sulfur butterflies in ŌĆ£Convocation,ŌĆØ suggest the ŌĆ£swing and riseŌĆØ of planets and ŌĆ£far quasar.ŌĆØ
Many of MorganŌĆÖs most affecting poems describe an embattled natural world where corrupting forces contaminate beauty. ŌĆ£BrownfieldŌĆØ describes a field filled with ŌĆ£industrial swill,ŌĆØ tatters of asbestos and rusting nails, styrofoam, grease and garbage bags; yet even here, Nature struggles stubbornly to reassert itself with a thriving patch of ironweed. In ŌĆ£ExpulsionŌĆØ Morgan compares humanityŌĆÖs withdrawal from polluted tracts of land to the loss of Eden. We are forced to leave because our eyes are ŌĆ£swollen redŌĆØ by a corrupting dust. Yet, even here, the stubborn persistence of ŌĆ£Poison OakŌĆØ demonstrates NatureŌĆÖs survival instinct ŌĆ£that will cross a meadowŌĆØ to claim a spot at the base of a tree.
My favorite poem in this collection is ŌĆ£Go Gentle,ŌĆØ a reasoned rebuff to the poet, Dylan Thomas who is remembered for his advice to the elderly: ŌĆ£rage against the dying of the light.ŌĆØ For Morgan, such a recommendation seems a bit melodramaic. After witnessing the death of relatives and friends, Morgan concludes that both those who watch and those who die ŌĆ£will plead for nothing but the right/ and gentle passage of the night.ŌĆØ There seems little point in delivering a death rant.
This is a gratifying collection. Although Robert Morgan is attracting national attention for his novels and historic biographies, I feel that his greatest strength lies in his poetry.
Terroir by Robert Morgan. Penguin Books, 2011. 95 pages.


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My DD is 4 weeks old and now all of a sudden im producing way too much milk, she splutters and coughs while nursing! My nipples are sore from pulling her off during let-down, shes constantly puking im think 5-6 sleepers so gets soaked a day!
I've tried the nursing only one side for 2 feedings in a row like i was told to, but shes still the same. Her poops are now green and im getting frustratedsince shes back to only sleeping 1.5- 2 hours in a row!
She seems like shes in painand you can tell the ofremilk is bothering her stomach!
any ideas of suggestions to make this go down faster? Formula is starting to look really good.. :(


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This photo contains one or more person(s) that I am currently unable to identify. If you can provide any informaion (even a guess is a starting place), please email me at email@example.com with your information!
The photos in my unknown photo collection could come from either my mother's family (Treat, Lawrence, and related family lines) or my father's family (Thompson, Stout, and related family lines).
Also, my Great-Aunt Mabel (Stout) Parsons was a school teacher in the Springdale schools for many years so some of the photos may be of her students.


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Pear-and-Goat Cheese CrostiniOctober 2010
A spontaneous soiree is perfect for the ultimate cold appetizer. Itll make your party feel like it was months in the making.
Makes: 8 servings
Prep: 20 mins
Bake: 35 mins
- 1/2 cup coarsely chopped walnuts
- 1 tablespoon plus 1 teaspoon honey
- 1 tablespoon brown sugar
- 3 large bosc pears--halved lengthwise, cored and cut lengthwise into 1/2-inch wedges
- 1 tablespoon butter, chilled and cut into small pieces
- 1 12-inch baguette, sliced 1/2 inch thick and toasted
- 6 ounces soft goat cheese
- 1 cup baby arugula
- Extra-virgin olive oil, for drizzling
- Coarse sea salt, for sprinkling
- Preheat the oven to 350 degrees . Line a baking sheet with parchment. In a small bowl, toss the walnuts with 1 teaspoon honey. Toss with the brown sugar to coat. Arrange in a single layer on the prepared baking sheet and roast, stirring once, until slightly candied, about 7 minutes. Transfer to a plate to cool. Discard the parchment.
- Increase the oven temperature to 400 degrees . Arrange the pears in a single layer on the baking sheet. Top with the butter and drizzle with the remaining 1 tablespoon honey. Roast, tossing occasionally, until tender and golden, about 25 minutes.
- Spread one side of the toasts with the goat cheese and top with the arugula. Drizzle with olive oil and top with the pear slices. Sprinkle with the candied nuts and sea salt.


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PORTUGAL TOUR (10D/9N) from €535
Tour Length:
10 days, 9 nights
Tour Themes:
When To Go:
All Year
Surrounded by the amazing scenery of Serra de S. Mamede Natural Park, Quinta do Barrieiro locates very close to Marvão. In an environment that contrasts with the typical landscape of Alentejo, the lime, the schist, the water and the green give a special charm to this place. But what really distinguishes it, making it unique, is the artistic sensibility of its owners.With his architectonic expertise, José Manuel Coelho managed to skilfully explore the specificity of the region's typical architecture and materials.He has designed an involving scenic space that superbly blends modernity and tradition. A rural-chic landscape that is the perfect exhibition stage to the amazing metal/stone sculptures of his wife, Maria Leal da Costa.


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Re: Tony to start 2nd
Smokeshow14 wrote:When your qualifying time is disallowed it is like you never hit the track. So everyone who qualified behind you qualified one spot up. It is different from when say someone blows an engine in practice, qualifies, but has to go to the back. Their qualifying lap was allowed. But since they changed their engine they go to the back and everyone in the lane that person was in moves up.
Get it?
No, I don't get it since Austin kept his and they had the same exact infraction. That is what I do not get... And Austin had the most coveted pit stall.


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President Barack Obama's press secretary said the president hopes Milwaukee Mayor Tom Barrett beats Republican Gov. Scott Walker in Tuesday's recall election.
Obama's spokesman Jay Carney was asked during a briefing Monday in Washington why Obama wasn't campaigning for Barrett in Wisconsin. Obama was in neighboring Minnesota on Friday but didn't venture into Wisconsin.
Carney said the president supports and stands by Barrett. He said "you have a unique situation in Wisconsin where the election is the result of a recall petition but the president absolutely stands by Tom Barrett and hopes he prevails."
Former President Bill Clinton did campaign for Barrett on Friday in Milwaukee.
Recent polls show Walker with a narrow lead over Barrett.


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Ocean Beach
July 4th Photoblogging, Ocean Beach
We spent the 4th of July in Ocean Beach. Below are some pics of the fireworks display and other…festivities.
The fireworks show was pretty, as these sorts of things usually are.
Immediately after the fireworks show ends, another OB tradition begins. The 4th of July Marshmallow fight. It started 40 years ago as a friendly marshmallow fight between some OB neighbors, but every one else quickly took up the tradition.
It's now become like a soft-candy-based Festival of Landru.
Happy Independence Day, everyone.


text: Don't let the size fool you. These Dallas Cowboys Toddler Jerseys are packed with a ton of Cowboys spirit, and they're just waiting for the perfect little fan to put them on. Find the jersey that correctly showcases your tot's Cowboys spirit right here at the Official Dallas Cowboys Pro Shop. Score big with official fan favorite Game Jerseys like Dez Bryant, Dak Prescott, Ezekiel Elliott, Sean Lee, or Jason Witten. We even have customized jerseys, so you can personalize it any way you want. Let your little one's show off their Cowboys pride with a Cowboys Toddler Jersey. Let everyone know which team they support.


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While MP4Nation's Brainwavz Beta I reviewed some time ago were ok-ish sounding for their $30 price tag – but didn't really exceed in any aspect over their similarly priced peers – Brainwavz now upped the ante with the introduction of the M2 in-ear phones.
The M2 are a bit more expensive than the aforementioned Betas, going for around $50, but to my ears they sound at least twice as good, so all is fine.
I am quite impressed by how far Brainwavz have climbed the audio quality ladder since the last time I tried some of their products. Read on to find out more about the M2.


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Nandrolone Decanoate
Nandrolone Decanoate
Chemical Name: 4-estren-17beta-ol-3-one decanoate
Molecular Formula: C28H44O3
Molecular weight: 428.65
Appearance: white or oyster white to pale yellow crystalline powder
Standard: USP28; BP2003
Nandrolone decanoate is an injectable sort of the anabolic steroid. Nandrolone decanoate displays relatively powerful anabolic attributes. Dissimilar testosterone, however, Nandrolone decanoate tissue-building action is attended by weak androgenic facilities. The modest attributes of nandrolone decanoate have made it among the most pop injectable steroids in global, highly preferred by athletes for its power to promote important strength and lean muscle mass increases without strong androgenic or estrogenic side effects.
Nandrolone decanoate is wide disposable in human andveterinary drug marketplaces. Structural. Nandrolone decanoate is a modified sort of nandrolone. Esterified steroids are proposed to prolong the window of therapeutical effect following administration, allowable for a lower periodic injection docket compared to injections of free (unesterified) steroid. Nandrolone decanoate offers a keen top in nandrolone release 24-48 hours accompanying deep intramuscular injection, which constantly goes down to near baseline points about 2 weeks later. The average depot-release half life of nandrolone decanoate is eight days.
Other supplier products
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text: Featuring surgical stainless-steel construction and offset blades, our nursing scissors are second to none. With bandage scissors, forceps, utility scissors and lister scissors available, we equip medical professionals for any situation. Providing high quality tools and accessories is our top priority! In addition, a portion of sales for certain scissors benefits the American Cancer Society, working to bring an end to this deadly disease. Make Scrubs and Beyond your choice today!


text:
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#98877 - 03/16/03 09:15 AM Information site
Carpal Tunnel
Registered: 01/18/01
Posts: 13858
This site has a lot of information worth browsing.
#98878 - 03/16/03 10:15 AM Re: Information site
Carpal Tunnel
Registered: 09/30/01
Posts: 6296
Loc: Piedmont Region of Virginia, U...
Good site for abbreviated Greek/Roman mythology.
#98879 - 03/16/03 11:55 AM Re: Information site
Carpal Tunnel
Registered: 01/18/01
Posts: 13858
"But wait! There's more"®
Almanacs, Atlas, Dictionary, Encyclopedia e.g.:
Plutarch , A.D. 46?c. A.D. 120, Greek essayist and biographer, b. Chaeronea, Boeotia. He traveled in Egypt and Italy, visited Rome (where he lectured on philosophy) and Athens, and finally returned to his native Boeotia, where he became a priest of the temple of Delphi. His great work is The Parallel Lives comprising 46 surviving biographies arranged in pairs (one Greek life with one comparable Roman) and four single biographies; some 19 short comparisons affixed to the lives are of doubtful authenticity. The English translation by Sir Thomas North had a profound effect upon English literature; it supplied, for example, the material for Shakespeare's Coriolanus, Julius Caesar, Antony and Cleopatra, and Timon of Athens. A translation by John Dryden was revised by A. H. Clough in 1864. Although Plutarch displays evident pride in the culture and greatness of the men of Greece, he is nevertheless fair and honest in his treatment of the Romans. As a biographer Plutarch is almost peerless, although his facts are not always accurate. Since his purpose was to portray character and reveal its moral implications, his technique included the use of much anecdotal material. Less known, but also of great charm and interest, are Plutarch's Moralia (tr. by F. C. Babbitt et al., 14 vol., 192776). They consist of dialogues and essays on ethical, literary, and historical subjects, such as The Late Vengeance of the Deity, On Superstition, The Right Way of Hearing Poetry, and Advice to Married Couples. Plutarch's quotations (frequent and long) from the old dramatists are often our only record of such writings.
See biography by R. H. Barrow (1967, repr. 1979); studies by C. J. Gianakaris (1970), C. P. Jones (1971), D. A. Russell (1973), and A. Wardman (1974).
#98880 - 03/16/03 12:01 PM Re: Information site
Carpal Tunnel
Registered: 01/18/01
Posts: 13858
Wanna watch an eclipse?
Eclipses of the Sun and Moon, 2003
Note: The day of an eclipse is given in Universal Time (U.T.) and may start a day earlier or later depending on your time zone. (See Phenomena, 2003, to find time of eclipse.)
* May 16. Total eclipse of the Moon. The beginning of the umbral phase visible in Europe, southern Greenland, eastern North America, Central America, South America, most of Antarctica, Africa, western Middle East, the Atlantic Ocean, the southeast Pacific Ocean, and the western Indian Ocean; the end visible in the southern tip of Greenland, North America except the extreme northwest, Central America, South America, part of New Zealand, most of Antarctica, western Africa, western Iberian Peninsula, the Atlantic Ocean except the extreme northeast, and the eastern Pacific Ocean.
* May 31. Annular eclipse of the Sun. Visible in northeast Africa, Europe except Iberia (including the British Isles), northern Asia, northern Greenland, northern Canada, and Alaska.
* Nov. 89. Total eclipse of the Moon. The beginning of the umbral phase visible in Africa, Europe, western and central Asia, Greenland, the Arctic region, eastern North America, Central America, South America except the southern tip, coastal Queen Maud Land of Antarctica, the western Indian Ocean, and the Atlantic Ocean; the end visible in Europe, northwest Asia, the Arctic region, Greenland, North America, Central America, South America, Antarctic Peninsula, Africa except extreme eastern part, western Middle East, the Atlantic Ocean, and the eastern Pacific Ocean.
* Nov. 2324. Total eclipse of the Sun. Visible in Australia, New Zealand, Antarctica, the South Pacific Ocean, and the southern tip of South America.
#98881 - 03/16/03 12:21 PM Re: Information site
Carpal Tunnel
Registered: 01/18/01
Posts: 13858
As a bit of trivia, I remember about Abraham Lincoln winning a case by proving that a witness had lied when he said he had seen the defendant by the light of the moon in the act of committing a crime. Lincoln quoted from an Almanac which said there was no moonlight on the night in q;uestion.
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text: Advocacy Page ContentThe AOA continually works to expand the public policy impact of osteopathic medicine at the federal and state levels of government by engaging members in advocacy efforts. Through events like DO Day on Capitol Hill, town hall meetings and health policy forums, AOA members help strengthen the profession's influence with legislators and policy makers. The Grassroots Osteopathic Advocacy Link (GOAL) furthers that mission by providing tools you can use to educate policymakers about DOs and help shape the future of health care. Get Involved With GOAL: Take action by writing your lawmakers on important policy issues that affect your patients and practice. WRITE TO CONGRESS Learn about key issues and get involved in federal legislative and regulatory processes at the grassroots level. READ THE ADVOCACY HANDBOOK Stay informed through email alerts with issue summaries and calls to action, as well as Washington Updates. REGISTER FOR GOAL ALERTS Lobby lawmakers in the nation's capitol during the AOA's premier osteopathic advocacy event of the year. ATTEND DO DAY ON CAPITOL HILL Share This Your browser does not support this functionality. Get Involved Hear from fellow DOs about the difference you can make in your profession by standing with the AOA. Watch the Video


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Every Tylure Kicker Shad is completely hand made one at a time to provide anglers with the highest quality lures on the water. Extremely realistic with hand painted detailing and a life-like profile, the Tylure Kicker Shad accurately mimics a live Shad. The bait's incredibly flexible two-joint system allows for free movement in the water and facilitates the bait's enticing swimming motion. Also, anglers can fish every Tylure Kicker Shad right out of the package because each one has been tank tested and hand tuned to ensure they swim properly before they leave the Tylure facilities.
Durability is also a major concern when targeting some of the strongest fish in the water and the Tylure Kicker Shad is built with that in mind. Stainless steel components, urethane construction, primer coating and a super tough clear coating process all combine to ensure maximum durability - strike after strike. All Kicker Series baits also come equipped with a "hook slot tube" to hold the ultra sharp Owner Treble Hook up against the body of the bait. This allows for better hooksets, as well as, a more realistic presentation (because the hook isn't dangling below the bait). Once a fish is on - the "slot tube" will come free so that the fish can't use the weight of the hook to throw the lure.
|TyLure Kicker Shad
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More U.S.-based restaurant companies are finding developers in the Middle East, making it one of the strongest regions for international growth of American brands. Eager regional investors and a strong economy have trumped concerns about unrest in the region, leading a wide swath of U.S. restaurant brands to partner with Middle Eastern companies to open units and expand operations. Slide show American restaurants expand in the Middle East RELATED • Middle East ...
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D.C.'s pit of despairJuly 17,2013There are countless oddities in the way Washington works, but few as mystifying as lawmakers definition of the word friend.
In other, saner walks of life, it means someone you yearn to see. In the Senate, it can also mean someone you yearn to see under the wheels of your sport utility vehicle, writhing in agony and wheezing surrender.
I assume this was the usage that Harry Reid, the Democratic majority leader, had in mind when he called Mitch McConnell, the Republican minority leader, my friend during a closely watched speech Monday. After all, everything else about Reids remarks and the furious days leading up to them reflected a state of play between the two parties, and the two men, that no conventional dictionary would ever describe as amicable.
Right now, the worlds greatest deliberative body, as the Senate has been called, looks a whole lot more like the set of The Jerry Springer Show. Is it any wonder that so many prominent pols are taking a pass on membership in the club? The one who most recently did so was Brian Schweitzer, the former governor of Montana, who announced his decision not to run for the Senate over the weekend.
I kicked the tires, Schweitzer, a Democrat, told The Associated Press, meaning he had mulled the idea. I walked to the edge and looked over. And saw what? A pit of bottomless despair? Ted Cruz ranting into the wee hours? Rand Paul filibustering like theres no tomorrow?
Schweitzer had previously commented, I am not goofy enough to be in the House, and Im not senile enough to be in the Senate. In years past, he might have been referring to the advanced age of many senators. In our grim present, he seemed to be saying that a person must be of bedraggled mind to court an assignment so acrimonious.
As potential newcomers say no, old-timers say goodbye, in numbers greater than before. Olympia Snowe, Ben Nelson, Kay Bailey Hutchison and Kent Conrad, among other senators, retired at the end of 2012. Carl Levin, Max Baucus, Tom Harkin, Tim Johnson, Mike Johanns and Saxby Chambliss have all announced that they wont seek re-election in 2014. The reasons vary, but the take-away is clear. The Senate doesnt exert the pull it once did. Its an arena of petty gamesmanship and pointless gridlock, which are engines of Reids understandable ire and reasons hes pushing a reconsideration of filibuster rules this week. The current Republican minority has been an epically obstructionist one.
On top of which, the gerrymandering of House districts means that when the Senate indeed manages to get something accomplished, the legislation is frequently torn apart, ignored completely or dead on arrival on the other side of the Capitol, said Chris Coons, a Delaware Democrat who was elected to the Senate in 2010 and used words like frustrating and disheartening to describe his experience since. In the Senate these days, the blush fades quickly from the rose.
Coons told me that while most of his Republican colleagues are personable and collegial, the exceptions hold inordinate sway, and that much of the time the chamber is either empty of any senators or one is giving a partisan screed to the cameras only.
Thanks to the voracious appetite of blogs and cable news and to all journalists tropism toward tantrums, the screed givers get more attention than the worker bees.
As for respect, well, thats gone the way of the dodo. You could at this point fill an entire book with pundits and politicians efforts at witty similes and metaphors for how low Americans opinion of Congress has sunk.
Referring to the oath of office that every lawmaker takes, Bob Kerrey said to me, The moment your hand comes off the Bible, youre in a profession where the approval rating is down there with waterboarding. I told him that he vastly underestimated the esteem for waterboarding.
Kerrey, a Democrat, served Nebraska in the Senate from 1989 to 2001. In 2012 he ran again (and lost). I asked him why hed bothered. He said that just as our country needs people to go down in a coal mine, we need people to brave the toxic realms of Congress. Coal mining and the Senate in one breath: that says it all.
If the Senate is this troubled, what hope exists for the federal government all in all? For its ability to solve problems, its appeal to high-minded individuals?
On Monday, in a voice of surprising sadness, Reid declared the Senate broken. He looked weary, beaten down: a mirror of Americans, whose faith in Washington has ebbed. When we look toward the Potomac, we see posturing in lieu of cooperation, tribalism in place of collaboration. And thats not what friends are for.
Frank Bruni is a columnist for The New York Times.MORE IN CommentarySure, you can buy your uncle a necktie that he wont wear, or your niece an Amazon certificate... Full StoryA lot of serious long-term national issues simply werent addressed in the recent national election. Full StoryI have written on the anomaly of the separation of the private and public sectors in our society,... Full Story
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1 of 1 photos
Sleigh Beds
Full- and Twin-Size Bordeaux Collection Bed Frames
The hardware holding the headboard and footboard can loosen or detach, posing a fall hazard.
For additional information, contact Samuel Lawrence Furniture toll-free at (888) 572-9889 between 9 a.m. and 5 p.m. ET Monday through Friday, or visit the company's website at www.slf-co.com
About 2,400 in the United States and 100 in Canada. (This recall was first announced in June 2012)
This recall includes Bordeaux Collection full- and twin-size sleigh beds with wooden headboards and footboards in a cherry finish. Each bed also has two matching wooden side rails. "Bordeaux" and a model number are printed on a white label on the back of the headboard and footboard. Model numbers for the recalled beds are 8070-242 and 8070-243 for the full-size and 8070-232 and 8070-233 for the twin-size.
The firm has received more than 100 reports of headboards or footboards detaching, including one report of a Florida man who injured his foot when a footboard detached.
Consumers should immediately stop using the recalled beds and contact Samuel Lawrence Furniture to obtain a free repair kit.
Furniture stores nationwide from August 2009 to April 2012 for between $300 and $400.
Poh Huat Furniture Ind., of Malaysia
Samuel Lawrence Furniture, of High Point, N.C.
The U.S. Consumer Product Safety Commission is charged with protecting the public from unreasonable risks of injury or death associated with the use of
thousands of types of consumer products under the agency's jurisdiction. Deaths, injuries, and property damage from consumer product incidents cost the
nation more than $1 trillion annually. CPSC is committed to protecting consumers and families from products that pose a fire, electrical, chemical or
mechanical hazard. CPSC's work to help ensure the safety of consumer products - such as toys, cribs, power tools, cigarette lighters and household
chemicals -– contributed to a decline in the rate of deaths and injuries associated with consumer products over the past 40 years.
Federal law bars any person from selling products subject to a publicly-announced voluntary recall by a manufacturer or a mandatory recall ordered by the
To report a dangerous product or a product-related injury go online to www.SaferProducts.gov or call CPSC's Hotline at 800-638-2772 or teletypewriter at
301-595-7054 for the hearing impaired. Consumers can obtain news release and recall information at www.cpsc.gov, on Twitter @USCPSC or by subscribing
to CPSC's free e-mail newsletters.
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Call to get product safety and other agency information and to report unsafe products.
Please use the below phone number for all media requests.
Phone: (301) 504-7908
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View CPSC contacts for specific areas of expertise
We are still interested in receiving incident or injury reports that are either directly related to this product recall or involve a different hazard with the same product.
Report a Product on SaferProducts.gov
The link you selected is for a destination outside of the Federal Government. CPSC does not control this external site or its privacy policy and cannot attest to the accuracy of the information it contains. You may wish to review the privacy policy of the external site as its information collection practices may differ from ours. Linking to this external site does not constitute an endorsement of the site or the information it contains by CPSC or any of its employees.
Click Ok if you wish to continue to the website; otherwise, click Cancel to return to our site.


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When I give my LO EBM, I'm having a hard time trying to figure out how to give him the bottle properly.
If I stop every one to two ounces to burp him, he loses interest and it's hard to get him to finish the rest of the bottle. I hate to waste breast milk.
If I let him drink almost the entire bottle, he will spit up big time.
What should I do? How do you give your LO the bottle? Any suggestions are greatly appreciated.


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Allen is just over 3 weeks old and he's very good at latching on. However, just recently his latch on my right breast seems to have changed. It's OK for the first few minutes then my nipple starts to sting - the part that's in the right side of his mouth. When I break suction and look at my nipple, it seems like maybe he's chewing on that part of my nipple.
I don't know how my nipple is migrating into this position, how to stop it, and why it only happens on the right breast? This is making my right nipple sore! I've been using the football hold during the day to rotate the pressure points and let my nipple heal, but at night we cradle hold and it still happens.
Any thoughts?


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"Deviating from faith, they are implicated in the darkness of perpetual blindness, although they have the day of Christ and the light of the Church before them; while seeing nothing, they open their mouth as if they knew everything, keen for vain things and dull for things eternal."
~ Ambrose, Bishop, Father and Doctor of the Church, Saint; commenting in the 4th century on the "wise of the world" who look askance at Christianity, a conflict that has existed from the very birth of the Faith (see "Science and the Church").


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Maui County Ocean Safety officers and State Department of Land and Natural Resources officials will be reopening the beach area in Ka'anapali where a surfer was bitten by a shark on Tuesday.
Officials closed the beach for a mile in both directions after the incident took place fronting the Maui Kai Condos, located at 106 Ka'anapali Shores Place.
The victim, a 58-year-old man from Marina Del Rey, Calif., is still hospitalized with two deep lacerations in his right thigh.
Initial reports from surfers stated that the shark might have been around 4-feet-long. However, county lifeguards now say based upon the victim's injuries and how he described the shark's head as the "size of a basketball," the shark may be anywhere from 8-to-10-feet-long.
The beach was closed from Black Rock to Honokowai and will reopen at noon Wednesday.
Lifeguards say since Tuesday morning they and DLNR officials have been monitoring the area using binoculars from rooftop of the Maui Kai, patrolling the shoreline on ATVs and the water via jet ski and they have not seen any sign of the shark.


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Leicester man arrested, charged in shooting of neighbor, two Vt. troopers - Updated 8:37 p.m.April 06,2014Rob Mitchell / Staff Photo
State Police vehicles line Lake Dunmore Road near the scene of two shootings in Leicester Sunday.Staff Report
A Leicester man who allegedly shot two Vermont State Police troopers in the head early Sunday morning has been arrested and charged with two counts of attempted aggravated murder.
Timothy Foley, 47, is also charged with two counts of attempted murder in a separate shooting earlier Sunday morning, which happened across the road from his home and left a man in the hospital with a gunshot wound to the head, state police said.
Foley, who was jailed in Rutland on Sunday for lack of $100,000 bail, is expected to be arraigned today.
The series of events began well before dawn near tiny Fern Lake.
State police from the New Haven barracks responded to a 911 call from 1496 Lake Dunmore Road in Leicester shortly before 3 a.m. Sunday.
The caller, a woman, said someone had entered her home and shot her husband in the head while they were both in bed, according to police.
According to police the Brandon Rescue squad took the woman's husband to Porter Hospital in Middlebury, from where he was taken to Fletcher Allen Health Care in Burlington. He was listed in stable condition Sunday afternoon, police said, and had been treated for a gunshot wound to the head. His name was withheld.
The police investigation led troopers across the street to the home of Foley, who would not come out of his residence, police said.
One trooper was able to speak to Foley on the phone from the home of a neighbor, while other troopers set up a perimeter outside his house, but Foley stayed put.
Flanked by members of the state police patrol division and criminal investigation team at a press conference in New Haven, State Police Col. Thomas L'Esperance described what happened next.
Two of the troopers were "behind the trees in the position of cover" in Foley's yard when he allegedly shot at them from his home with a shotgun and hit one of them in the face with shotgun pellets, L'Esperance said. The other trooper returned fire with an AR-15 patrol rifle, covering the first trooper's move to safety. The second trooper was then also shot in the head with a shotgun, L'Esperance said.
Both troopers were taken by other troopers to Porter Hospital. One was treated and released, while the other was taken to Fletcher Allen Health Care and was "in good shape, he just has to have some pellets removed from his head," L'Esperance said. Their names are being withheld until today.
"In one respect, we're elated that the troopers are fine," L'Esperance said. "We are very fortunate that this press conference doesn't have a more somber feeling to it."
But L'Esperance said the incident goes to show the danger police face in the course of their jobs.
After the exchange of gunfire, a negotiator from the state police Hostage Negotiation Team in the Rutland barracks was able to get Foley back on the phone and convince him to leave his home by about 6 a.m.
"It speaks to the training, the experience, of those troopers that were left at the scene after two fellow troopers were transported," said L'Esperance. "They took the emotion out of it, and did the right thing. And took him into custody without incident."
The colonel said Sunday there was no clear motive for the shootings, however, they did not appear drug related. Foley was questioned at the New Haven state police barracks Sunday afternoon and a search warrant for his home was obtained. He does not have any serious crimes on his record, L'Esperance said, dating back a couple of decades. Detectives from the Bureau of Criminal Investigation were investigating at the scene Sunday, and the Crime Scene Search Team was still processing the shooting scenes Sunday afternoon. Patrol cars were stationed to the north and south of the crime scenes, turning drivers away.
The homes are on a rural stretch of paved road that runs along the east shore of Fern Lake, just south of Lake Dunmore and Branbury State Park, among year-round residences and summer cottages. Leicester is a town of about 975 in Addison County. The area where the shootings occurred is known locally as "Satans Kingdom," a moniker likely applied by an early resident who was expecting "fertile, rolling acres and had received rocks and hills instead," according to the book Vermont Place Names by Esther Swift.
Leicester Select Board chairwoman Diane Benware confirmed that according to Leicester town records, Joyce and Mahlon McCoy live at 1496 Lake Dunmore Road. She did not know Foley, she said, and said the McCoys mostly kept to themselves.
Benware said she could not remember another incident like this in Leicester in the recent past.
According to the minutes from a Leicester Zoning Board of Adjustment meeting in 2012, Mahlon McCoy is "severely handicapped" and uses a wheelchair.
A resident of Lake Dunmore Road near the shooting scene, who declined to be identified, reported hearing eight or nine shots in close succession just before dawn.MORE IN This Just InMONTPELIER A new report from a commission that studied the cost, availability and quality of... Full StoryVermont fish hatchery changes focus, looks inland
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Bicycle Network: Ride2Work (178)
Ride2Work encourages Australians to start riding to work and promotes commuting by bike as a regular habit.
With more than 67,000 registrations, Bicycle Network's Ride2Work Program is the largest national behaviour change program of its kind. It encourages Australians to start riding to work and help keep them riding as a regular habit.
Ride2Work has seen a dramatic increase in the number of people choosing to ride to work. A staggering 43% of new riders who registered in 2015 reported that they're still riding to work - weekly or more - when surveyed in March 2016, five months after National Ride2Work Day.


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The 2013 Harrah's Stir Cove Summer Concert Series
After 10 years of rocking the metro, Stir Concert Cove has solidified itself as the Midwest's premiere, outdoor concert venue.
Stir Cove hosts some of the biggest names in the industry with show stopping performances all summer long. With seating for 3,500 people, Stir Cove provides live entertainment in a truly unique setting.
Below is the 2013 Summer Concert Series at the Stir Cove. Tickets for all shows go on sale to the general public on Friday, April 5th. Tickets available at Stircove.com or by phone at 1-800-745-3000. More shows will be announced soon.
Click Here to visit the Harrah's Stir Cove website for the latest announcements and special offers.
Friday, August 30, 2013 8:00pm
Harrah's Stir Concert Cove
One Harrah's Blvd.
Council Bluffs, IA
Tickets: $41
Venue Information:
Handicap accessible seating is available for guests with disabilities and their companions; including guests with wheelchairs, hearing and visually impaired and guests with mobility impairments. Arrangements can be made by calling 712-329-6499.
Upon request, a Sign Interpreter will be provided. Please contact the venue at 712-329-6499 at least three (3) weeks prior to the show.
Handicap accessible parking is available for all events West of the venue. Please display the proper place card on your rearview mirror or license plate.
Service animals are welcome and request they remain on a leash or harness at all times. If you are bringing a service animal, please notify the venue at 712-329-6499 so seating can be arranged for you.
Effective July 1, 2008, smoking will not be permitted in Stir Cove persuant to the Iowa Smokefree Air Act. For more information or to register a complaint call 1-888-944-2247 or visit www.IowaSmokefreeAir.gov.
Box Office Hours
Stir Cove Box Office: 6:00pm – 9:30pm*
*Day of show only.
We accept the following:
Cash, AMEX, Mastercard, Visa, Discover
Will Call Tickets
Will Call tickets are available for pick-up the day of the show beginning four (4) hours prior to the concert.
Cancellation Policy
All Stir Cove shows are rain or shine. The decision to cancel the show due to lightning will be based on a mutual agreement between Caesars Management and the Artist Management.
Refund Policy
What to Bring
PLEASE NOTE: Due to artist restrictions, some items listed above may not be allowed for certain shows. Please call 712-329-6499 for show specific restrictions the week of the show.
What Not to Bring
Our guests' safety and enjoyment are our primary goals. You may be subject to search at certain events. Should you arrive with a restricted item in your possession, you will be asked to return it to your vehicle.
Harrah's Stir Concert Cove reserves the right to refuse admission to anyone.
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American Authors 7-30-14
Fitz & The Tantrums 7/28/14
O.A.R Q Acoustic Leinie Lounge 6/15/14
NeedToBreathe Q Leinie Lounge 6-11-14
Grammer De Mayo Leinie Lounge
ZZ Ward 03/27/14
Uncharted Q Acoustic Leinie Lounge with Yuna
Draftmasters Keg Club Meeting Roja 7-30-13
Plain White T's Q Acoustic Leinie Lounge 7-18-13
Family of the Year
Draftmasters Keg Club Meeting Fox & Hound 6-21-13
Honor by August
Draftmaster Keg Club Tanners 5-22-13
Andy Grammer & Parachute 3.29.2013
Ed Sheeran Q Acoustic Leinie Lounge 3.14.13
Neon Trees 3.3.13
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Medical professionals around Madison say the flu virus is fast and furious this season, and they have a special warning for pregnant women this year.
According to the Wisconsin Department of Health Services, 33 people have been hospitalized so far for the flu.
This time last year, there were no recorded hospitalizations.
Among those treated in a hospital after coming down with the influenza virus, four pregnant women have been hospitalized for the flu statewide.
"We really haven't heard a whole lot about pregnant women since the swine flu, or the H1N1 of 2009," said St. Mary's hospital nurse epidemiologist Ellen Smith, "where we saw a lot of pregnant women that year as well that were high risk and really quite ill."
Smith says the early numbers are concerning, and expecting mothers are at risk, just like the elderly or young children.
"Pregnancy does put a stresser on the human body," Smith noted, "and it's important to protect yourself and protect that unborn child, so it's something that we really need to think about."
With a few mild years for the flu, Smith expects many are putting off getting a flu shot and not thinking much about the season.
She adds it takes two weeks to develop immunity after receiving the vaccine, so everyone, including pregnant women, shouldn't put it off.
"Often times pregnant women will say they don't want to put anything into their body," Smith said, "but the single most important thing that they can do to prevent influenza to themselves and to their family is to get immunized."
Some doctors say that action also protects the baby.
"Vaccinating moms during pregnancy protects not just mom, but also protects their newborns from influenza for up to six months after birth, because antibodies against the flu pass from mom to baby," UW obstetrician/gynecologist Dr. Sarah Bradley said. "This is the only effective way to prevent the flu in newborns as the vaccine can't be used in infants younger than six months."
According to UW physicians, state division of public health epidemiologist Tom Haupt said the women were admitted to hospitals in Milwaukee and Waukesha counties in southeast Wisconsin.
Haupt added that the virus could affect expectant mothers in southern Wisconsin, including Dane County.
Haupt says for the entire 2011-12 flu season, nine pregnant women were hospitalized in Wisconsin.
Smith says the other easy ways to protect yourself and others from the flu is just what mom taught you.
She says covering your coughs, washing your hands, and skipping the social gatherings when you don't feel well can go far to prevent the spread of flu this holiday season.


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Susie and Chuck Williams want to renovate a 10,000-square-foot building, the former home of Franklin Orthopedic Specialists in Franklin, for the childcare center. They've yet to buy the building, however, and are in the beginning stages of raising the necessary funds. They have started a nonprofit for fundraising purposes.
"We started four years ago trying to find a building," Susie Williams said. "We couldn't find anything that would pass until we found this. Now, we are looking for angels."
Williams is the former owner of a daycare and she's been a foster parent for 39 years. Her husband retired from the vending business.
There's no doubt that childcare is a critical issue in Macon County. In 2009, a county committee found that Macon County doesn't have enough affordable, quality childcare, particularly for those under 2 years old.
The study, using 2008 population statistics, showed there were 1,147 children under 2 years old in Macon County. Working from the assumption that half were cared for by a stay-at-home parent or other family member, the study pegged demand in the county at 574 slots for infants and toddlers.
The capacity at that time fell well short — there were only 210 spaces available, the majority of which are reserved only for low-income families. That means more than 300 families are stuck on waiting lists or are sending their children to unlicensed providers.
Tara Raby, a single mother of two children who works in the county tax office, struggled to find childcare for her now 2-year-old son, Thomas. She finally found an open slot at Trimont Christian Academy.
"It was a challenge to get him in," Raby said. "There is a long waiting list, and there's not a lot of opportunities here."
Tommy Jenkins, director of the Macon County Economic Development Commission, said having adequate childcare is important when it comes to recruiting and retaining businesses. He said he hopes the Williams can successfully open a childcare center.
"Our workforce could use all the help they could get," Jenkins said. "Quality childcare should be part of any community's economic development plan."
The Williams' childcare center would serve children ages six weeks to six years.
"The study brought out what the needs are for the county," Susie Williams said, adding she and her husband want to do much more than just open a basic childcare.
"It's going to be a phenomenal operation, a true learning center," she said.
The couple envision a 24-hour childcare center that would feature art and music teachers and other learning opportunities for the children going there. Children with special needs would have trained employees to work with them, and therapy also would be available. Williams said the center would have a director and would employee 35 people per each of the three shifts it would be open.
Williams admitted the expense would be "tremendous." And despite hoping to be open in the next year, "that's contingent on finding the money," she said.
Commissioner Ronnie Beale, who played a key role in initiating the childcare study, wished the Williams well but said other efforts to remedy the county's childcare problem would continue.
"If we can help them in any way, we will," Beale said. "But, we're continuing to look also at what we can do to improve the situation, particularly for infant care."
The start-up costs, especially outfitting a building to house a child care center, seem to pose the biggest obstacle, and that's where the county could potentially help, Beale said.
"I don't think the county will ever get in the childcare business, but we can certainly be a partner," Beale said. "What my vision would be is we would help with the property and bricks and mortar then put it under the umbrella of Macon Program for Progress."
Macon Program for Progress, a private nonprofit community action agency, supplies the bulk of the childcare slots in Macon County for children under the age of 2, but the federally funded programs are only available to families that meet federal poverty guidelines.


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[Updated: 01/10/2012]
Weather conditions are the responsibility of the game officials, coaches, tournament directors and club administrators. All should be aware of the potential dangers posed by different weather conditions and work together to keep the players and other participants as safe as possible. If the weather conditions warrant, game officials and coaches should discuss before the game starts what the procedures will be to insure the safety of the players. Tournament directors should monitor weather conditions including the warnings and watches issued by the National Weather Service. In the event of sudden changes, the tournament directors should have a means of sending warnings to the site officials. A weather plan should be provided to the participating teams to allow a clear understanding of shelter locations, evacuation plans and how the weather will affect tournament results. Club administrators should perform similar functions for league play.
Technology has improved the monitoring capability for all concerned. Weather radios are relatively inexpensive and provide virtually instant information on alerts, watches and warnings. Lightning detectors can take the guesswork out of how far away lightning is. Cell phones and two-way radios can meet communication requirements to implement weather plans.
Preliminary Concerns
It is strongly recommended that clubs purchase weather radios and have them available for on site monitoring. Lightning detectors are recommended also. Coaches may wish to consider obtaining their own weather radios.
Rec Plus and competitive league play obviously involves travel. Conditions in one location may be very different from another, especially the further apart the two locations are. The coaches are responsible for keeping informed of the weather conditions at home, along their route to the game and at the game site. The coaches are also responsible for communications with the opposing coach and their own team in the event of inclement weather. Discussions between the coaches must provide for common sense to prevail. The Competitive Representative must be informed immediately of any games affected by inclement weather.
Tournament directors should provide participating teams with the weather guidelines for the tournament. Some things to consider are:
Severe storms can produce high winds, heavy rain, hail, lightning, thunder and/or tornados. If a severe storm approaches the playing area, the safety of the players is the number one priority of coaches and referees, and may require that the game be suspended while shelter is sought. In the event the game is suspended, ALL participants MUST clear the field immediately and move into their cars or other permanent shelter.
High winds can create problems by dust and debris being in the air or blowing over objects. Heavy rain can create hazardous field conditions or lead to flash flooding. Hail can cause injury. Lightning and thunder is discussed separately below. Tornados are obvious dangers of any severe storm. Use common sense and seek shelter as appropriate.
Lightning is the second leading cause of storm-related deaths (flooding is first). Lightning can strike up to 10 miles outside of a thunderstorm, literally a bolt from the blue. The danger from lightning can persist for 20-30 minutes or more after a thunderstorm has passed. The National Weather Service does not issue watches or warnings for lightning by itself. However, the National Weather Service does advise that if you see a lightning bolt and hear the thunder in 30 seconds or less, you seek shelter and wait 30 minutes before resuming outdoor activity.
If a person can hear thunder, or see lightning, the danger already is present. A clear, sunny sky overhead with storm clouds nearby can still be dangerous.
Referees and Coaches should adhere to the following:
Heat is a problem when it prevents the body from cooling itself. The hotter the body gets, the more likely it is to increase fatigue levels, develop cramps and increase the possibility of heat exhaustion and heat stroke. The hotter and more humid the weather, the faster these problems can develop. Temperatures as low as 65 degrees, with a relative humidity of 100%, can be serious.
1. A heat index chart should be given to every coach and referee (www.nws.noaa.gov)
2. Games need to be adjusted as the heat index rises:
a. Mandatory water breaks
b. Go to quarters
c. Shorten the games
3. Provide training to coaches to teach the signs of heat exhaustion and heat stroke.
Club administrators and tournament officials are responsible for monitoring the heat index (by weather radio, online or the Weather Channel) and keeping the participating teams and game officials informed of the heat index. Coaches are encouraged to also monitor the conditions.The following are recommended when there is a possibility of dangerous high heat index:
|Heat Index
|Up to 89°
|Normal Play
|90° - 99°
|Mandatory two-minute water breaks per half with running time. Each half shortened by five minutes.
|100° - 105°
|Mandatory two-minute water breaks per half with running time. Each half shortened by ten minutes.
|Suspend Play
For further information, please check the NOAA website for additional information in regards to how temperature and humidity combine to make it feel hotter.
Special Heat Rules for TOPSoccer
If the heat index exceeds 95 degrees, the practice or game is immediately suspended. If the National Weather Service issues a heat index warning that will exceed 95 degrees, the MYSA TOPSoccer Committee Chairperson (or designee) will notify TOPSoccer administrators by 1:00 p.m. on practice/game day that practices/games are suspended. Parents and/or legal guardians should also listen for heat warnings and take appropriate action.
For fall play, cold becomes a factor. Players should be allowed to dress in appropriate clothing. Field conditions will be affected by freezing rain, sleet and snow. The ground may become frozen and be unsafe for play. Temperature means either ambient (still air) or wind chill index. Check weather radio frequently for temperature and weather conditions.
|Cold Index
|46° and higher
|No Change
|45° and lower
Allowable Additional Clothing:
Clothing NOT Allowed:
|40° and lower
|35° and lower


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Vt. project aims to cut health care costsBy PETER HIRSCHFELD
Vermont Press Bureau | October 06,2013MONTPELIER The launch of the states new online insurance marketplace last week has temporarily sucked the oxygen out of the debate over health care reform in Vermont. But as the public gaze turns toward a website designed to help people buy insurance, work continues behind the scenes to limit the price Vermonters will have to pay for it.
And later this month, state officials will launch a three-year, $45 million grant-funded initiative that aims to redefine the scope of the health care industry and reduce costs in a sector that now accounts for about one-fifth of the states gross domestic product.
Vermont is one of only six states nationwide to land a federal State Innovation Model grant. The SIM money is meant to incubate nascent health care initiatives whose successes might eventually be repeated elsewhere.
As the Centers for Medicare and Medicaid Services explains it, Vermont will develop a high-performance health system that achieves full coordination and integration of care throughout a persons life span, ensuring better health care, better health, and lower cost for all Vermonters.
To accomplish the feat, a team of more than 200 doctors, hospital administrators, state bureaucrats, information-technology specialists and human services workers, among others, will try to fuse together a patchwork of health-related fields whose failure to communicate effectively has made for an inefficient delivery system.
We are talking about a health system that is terribly fragmented and lacks the integration we have all talked about, Mark Larson, commissioner of the Department of Vermont Health Access, told a panel of state lawmakers last week.
The reality is different folks are in charge of different pieces, and in terms of creating real structural reform in how the system operates, we need the different people with control over different pieces to try to work together.
The three-year grant builds off a foundation years in the making, wherein teams of providers from doctors and nurses to counselors and nutritionists assume collective responsibility for all aspects of an individual patients care.
The so-called Blueprint for Health, as the model is known, has begun to evolve thanks to the creation of Accountable Care Organizations, or ACOs, in which teams of hospitals and providers integrate payments and services across the health care system.
Vermont has two ACOs. One includes Fletcher Allen Health Care in Burlington, Dartmouth-Hitchcock Medical Center in Lebanon, N.H., and every community hospital in Vermont. The other includes independent practitioners. An application for a third ACO is pending.
Al Gobeille, chairman of the Green Mountain Care Board a five-person panel established by the Legislature in 2010 to set insurance rates, approve hospital budgets and oversee payment reform initiatives says that if Vermont health care reform is a sailboat, the SIM grant means we just got a lot more wind.
He says, Its the money and the organizing and the influence that accelerates our ability to do things we were already working on.
Examples of existing integrated-delivery projects include an initiative at Rutland Regional Medical Center, where doctors and administrators decided to see if they could reduce re-admission rates for people with congestive heart failure.
The project, which involved 80 patients, successfully reduced the re-admission rate to zero, according to Gobeille.
Theyre able to manage patients once theyre discharged from the hospital either at home or at a nursing home by increasing the skills of providers in those settings, he said.
At Northwestern Medical Center in St. Albans, meanwhile, health care workers have gone outside the conventional care model to reduce the estimated 8,100 avoidable emergency room admissions at that facility every year.
Richard Slusky, director of payment reform for the Green Mountain Care Board, says the purpose of the next phase of reform is to scale those kinds of initiatives, and employ the same kinds of strategies across provider networks to spark more systemic change.
Ultimately I think it will be in the interest of ACOs to look at these different approaches and say, Well, maybe we can apply them in a broader scale or scope, Slusky says. Because if this is a means of improving the quality of care and reducing cost and improving patient experience, we can benefit financially from this.
The launch of the SIM project will for the first time see the inclusion of Medicaid-eligible patients in the ACO model.
Anya Rader Wallack, former chairwoman of the Green Mountain Care Board who has since been hired by the state to lead the SIM grant initiative, says the expanding needs of Medicaid patients creates an opportunity to bring in components of the social-services network that havent traditionally been involved in the medical system.
ACOs benefit financially by reducing costs across a specific population. If they succeed, they get a share of the savings. If they dont, they could potentially lose money.
Since the cost of care for Medicaid patients might include not only medical procedures and pharmaceuticals but home care, personal care, case management and other services available to the poor, Wallack said hospitals will have a newfound incentive to reduce costs in those areas as well, and, in so doing, redefine what it means to make a patient well.
It gives us an opportunity to use these payment-reform models to affect much broader integration and much broader change potentially, Wallack says. So to me that is the promise of Medicaid, that it actually takes us into some of the other services where we can, as a state, think about how we spend state dollars, and shift money to places where we could get better results for them.
Reduced costs arent the only metric by which ACOs will be judged. Patient outcomes and patient experience also will be gauged, according to Slusky, who says there are reliable ways of measuring those variables.
Precisely what form the SIM model assumes is still unclear. The state has yet to decide whether the Medicaid savings program will be conducted under the auspices of an existing ACO, or if it will reconstitute existing ACOs for the project.
The SIM project will also seek to achieve savings among populations of patients who get their insurance through the private carriers Blue Cross Blue Shield of Vermont and MVP.
Gobeille says success will be measured in the size of future hospital budget proposals, in the rate increases sought by insurance providers, and in the easing of the pressure on Vermonts Medicaid budget.
The question is will we see payers not asking for rate increases as high, will we see Medicaid budgets come in below the actual target? he says. And we have seen that in the last 12 months in the state of Vermont, so some of this work is already having consequences.MORE IN This Just InMONTPELIER A new report from a commission that studied the cost, availability and quality of... Full StoryVermont fish hatchery changes focus, looks inland
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text: What type of vision plans do you offer? Please click here to learn more about Davis Vision products and services. How can I find a Davis Vision provider? If you are a registered user for Benefit Manager™, log in and use our "Find a Provider" search tool. If you are a current Davis Vision client and do not use Benefit Manager™, you may locate a provider by logging in as a member. If you are currently a Davis Vision client, you may request access to review our provider network by contacting a Davis Vision client manager. You can also speak to a Customer Service Representative by dialing 1-800-278-6673. How can I sign up to use Benefit Manager? Contact your Davis Vision Client Manager. If you do not know the contact information for your Client Manager, simply fill out this form and someone from our team will get in touch with you shortly. How can I sign up to receive my invoice electronically (e-Bill)? Please fill out this form and fax it to 1-800-646-5824. If you have questions concerning e-Bill or the completion of this form, please call 1-877-393-7801 and choose option 1. Your assigned Client Manager can also assist with this process. Can members receive care from the provider of their choice? Yes. The majority of Davis Vision plans offer both in-network and out-of-network benefits, allowing members the freedom to visit any provider. With that being said, members receive the greatest benefit value when they visit an in-network provider at one of our 60,000 points of access. Due to the significant savings available with our participating providers, some of our clients prefer to offer in-network benefits only. Do members need a claim form for services? When visiting an in-network provider, there is no need for a claim form. A member simply provides his or her ID number when making an appointment and the provider will then verify eligibility and benefits. If your group's vision benefit includes an out-of network benefit, members may visit out-of-network providers. In this instance, members will be responsible to pay the provider's charges at the time of service, and then submit a claim form for reimbursement. Claim forms are available on our website or by calling our Customer Service Center. Do you offer online tools for benefits administrators? Yes. Davis Vision offers a number of online capabilities that greatly assist with benefit administration. With Benefit Manager™, groups have the ability to locate providers, access forms (including benefit booklets and out-of-network claim forms), check enrollment and eligibility for members and access educational vision information. Groups can also enjoy the convenience of e-Bill, a secure online system that offers the ability to make payments, view past and current invoices/payments, and export the data into Microsoft Excel for your reporting purposes. For more information about Davis Vision (more…)


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PHILADELPHIA - A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy.
Essentially, says senior author Eric Brown, PhD, Assistant Professor of Cancer Biology at the University of Pennsylvania School of Medicine, the findings highlight the fact that day-to-day maintenance required to keep proliferative tissues like skin and intestines functional is about more than just regeneration, a stem cell-based process that forms the basis of tissue renewal. It's also about housekeeping, the clearing away of damaged cells.
Whereas loss of ATR causes DNA damage, the job of p53 is to monitor cells for such damage and either stimulate the early demise of such cells or prevent their replication, the housekeeping part of the equation. The findings indicate that as messy as things can become in the absence of a DNA maintenance protein like ATR, failing to remove resulting damaged cells by also deleting p53, is worse. "Because the persistence of damaged cells in the absence of p53 prevents appropriate tissue renewal, these and other studies have underscored the importance not only of maintaining competent stem cells, but also of eliminating what gets in the way of regeneration," explains Brown.
"An analogy to our findings is what happens to trees during the changing seasons," says Brown. "In springtime, leaves are new and undamaged. But as the summer wears on, the effects of various influences - insects, drought, and disease - cause them to lose the pristine qualities they once had. However, the subsequent fall of these leaves presents a unique opportunity for regeneration later on, a chance to rejuvenate from anew without pre-existing obstacles. Similarly, by suppressing the accumulation of damaged cells in tissues, p53 permits more efficient tissue renewal when ATR is deleted."
Cells without ATR that remain uncleared may be block tissue regeneration either by effectively refusing to relinquish space to undamaged cells, or by secreting signals that halt regeneration until they have been removed.
These results came as something of a surprise, says Brown. Previous studies pairing DNA-repair mutations with p53 mutations always led to a partial rescue of the DNA repair mutation "We think this happens because p53 loss helps cells with just a little DNA damage to continue to contribute to the tissue" says Brown. So at a minimum, the team expected nothing to happen.
"But we got the opposite result: Absence of p53 did not rescue the tissue degeneration caused by ATR loss, it made it much worse. This result suggested that allowing mutant cells without ATR to persist is more harmful to tissues than eliminating them in the first place." Brown speculates that could be because the ATR mutation produces much more damage than most other DNA-repair defects.
According to Brown, their findings and those of other laboratories also reinforce the potential of a new therapeutic for cancer. That's because, among their other discoveries, the team noticed that cells missing both ATR and p53 have more DNA damage than those missing either gene alone. As a large fraction of human cancers have p53 mutations, he says, "p53-deficient tumors might be especially susceptible to ATR inhibition." Indeed, clinical trials already are underway involving an ATR partner protein called Chk1. "Our study provides supportive evidence for the potential use of ATR/Chk1 inhibitors in cancer therapy," says Brown
The report was supported by the National Institute on Aging and the Abramson Family Cancer Research Institute.
Laboratory members Yaroslava Ruzankina, PhD and MD/PhD student David Schoppy are lead authors of this study. Amma Asare, Carolyn Clark, and Robert Vonderheide, all from Penn, are co-authors.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Lancaster General Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.
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