text:
19 years of experience
Accepting new patients
4755 Ogletown Stanton Rd
Newark, DE 19718 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
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Dr. George Kimbiris, MD is board certified in Diagnostic Radiology.
- He has special expertise in 2 areas:
- Peripheral Vascular Diseases (Peripheral Artery Disease)
- Transjugular Intrahepatic Portosystemic Shunt (TIPS)
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Dr. Kimbiris graduated from Drexel University , Philadelphia.
Dr. Kimbiris has 2 hospital affiliations:
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- Wilmington Hospital
- Greek
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- Dr. George Kimbiris MD is a male Diagnostic Radiologist, has 19 years of experience and practices in Diagnostic Radiology.
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Dr. George Kimbiris practices Diagnostic Radiology near Newark, DE.
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text: Watch a horse lead police on an eight-mile chaseMatt Hardigree7/07/11 9:30am50EditPromoteDismissUndismissHideGo to permalink Officers in Lawrence Township, Ohio spent the better part of an afternoon chasing a suspect down a rural highway. The suspect, named Java, was clearly unarmed and maintained a low speed while weaving in and out of traffic. He's a horse, of course of course.

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Generally, a portraitist is only as good as his subjects. Up until now, this has worked in Jock Sturges' favor, as he's photographed nudist families in Northern California and the South of France, making a name for himself as a poet of the pubescent pastorale, his nymphets shimmering with down and dew. For all the notoriety of his subject matter, Sturges has never trivialized his models' T&A; their nudity is a vehicle toward simplicity, drawing our eyes not to naughty bits, but to faces, eyes and what presumably lies behind them. Sturges has always had a knack for capturing the implacable gaze: an open expression that suggests an old soul reawakening inside a young mind. Whether such precocious wisdom actually exists behind these tawny, freckle-faced facades is immaterial; the appearance of wisdom within the frame is sufficient. Which brings us to Sturges' latest outing at Butters, in which the contemporary zeitgeist seems finally to have caught up with the artist and turned his romantic visions from honeyed to hackneyed.
The photographer tries, oh how he tries, to plumb his subjects' depths, only to run aground in shallows; searching for a Mona Lisa smile, he finds only a Barbie doll's empty stare. The tweener and Gen Y girls populating these pictures harbor no secrets in their eyes, only boredom. They are here on this nude beach because their parents made them come; they would rather be texting their friends or downloading ringtones. From their vacant semblances Sturges wants to coax the same Bertolucci burnish in 2006 that he captured in 1976. Alas, XBox and wi-fi have leeched the enigma out of young eyes, leaving vapidity in the void where possibility used to reside. In the absence of the pregnant gaze of old, Sturges forces his models to turn away (as in Fanny, D106) or to feign depth where none is present. In Fanny, D107, the eponymous model flexes her forearm with Popeye machismo, but her sparkless eyes keep the image from being the feminist, genderqueer statement it desperately wants to be. And so Sturges retreats into the forest, photographing Vanessa et Miranda in backlit wide shot, two would-be sprites frolicking among the trees, reduced to silhouettes. Pity poor Sturges: Only distance and lighting tricks can turn his displaced mall rats into myths and metaphors.
Butters Gallery, 520 NW Davis St., 2nd floor, 248-9378. Closes May 27.


text:
Falling Backwards: A Memoir
A Memoir
by Jann Arden
- #3963 in Biography & Memoir
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Jann Arden is funny. And sincere. She has legions of devoted fans. And a radio show. She is a darling of the music scene - always candid, always unplugged. You thought you knew Jann Arden, but there is more - to her readers' delight, in Falling Backwards Jann reveals her childhood, her bond with family, her struggle in the formative years and what keeps her so grounded in the whirlwind entertainment industry. Jann has always been true to herself, except for a minor lapse when she was young. Oh wait, wasn't that all of us?
From the tender and honest to the laugh-out-loud funny, Jann's stories from home and from the road during her pre-celebrity years will take you to unexpected places, including high school parties in farmer's fields, sleepovers under the stars, hard-to-believe summer jobs and the time she was stuck upside down in a brick barbecue. She reminds us of the inestimable value to a child of having teachers who believe in you and wide open spaces to play. But with the good times come the bad (and not just the bad perm). Jann opens up about the darker side of her so-called prairie perfect nuclear family and the first signs that her eldest brother was a uniquely troubled young man. In the days when Jann was experiencing a lot of firsts - first school play, first home perm, first kiss - how lucky for all of us that she stole away to her basement and taught herself her first song on her mother's guitar.
In addition to being an incredible musician and multi-award-winning lyricist, Jann is a natural writer and simply an inspiration. Jann will capture your heart - and keep you in stitches - with her powerful stories about coming of age as an artist and as a human being. Jann brings her wit and that infectious sparkle to everything she does. This book is no exception.
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Great Read
I love her realness, compassion and her talent.by wayne on July 20, 2013
Falling Backwards: A Memoir
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by on October 28, 2016
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- Knopf Canada, November 2011
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realmagick.com The shrine of knowledge.
Munnar History
A selection of articles related to munnar history.
Original articles from our library related to the Munnar History. See Table of Contents for further available material (downloadable resources) on Munnar History.
- Indian History Rewritten
- The Indian civilisation, considered to be the product of clash and subsequent inter mixture of the white-skinned civilised invaders and the dark savages native to India, has been rightly questioned in recent years, and the mischievously fabricated history of...
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- History of the Egyptian Religion, part I: Early Dynastic Period
- I - Predynastic - Early Dynastic Period. The temples were in essence the *Home of the God* and thus a place where only Pharaoh as the Son of God and those he appointed as his deputies, could meet with the god. This goes all the way back to Archaic and...
Religions >> Egyptian
- History of the Egyptian Religion, part II: The Old Kingdom
- II - The Old Kingdom ca 2686-2181 BC During the Old Kingdom the Egyptian society moved from tribal communities to a fully developed theocratic system, where the power of the king was absolute. The great pyramids of Dynasty 4 was made possible by technological...
Religions >> Egyptian
- History of the Egyptian Religion, part IV: Middle Kingdom
- First Intermediate - Middle Kingdom (ca 2181 -1786 bc.) The powers that built the solar temples of the 5th dynasty and the pyramids of the 6th dynasty weakened towards the end of the Old Kingdom, perhaps as a result of eroding economics, leaving the King less...
Religions >> Egyptian
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- Fort Kochi: Visit Kerala's best kept secret
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- Camera trap creates history at park
- Talking to The Hindu, Munnar Wildlife Warden G. Prasad said the saddleback was noticed by the authorities on the grassland cliff on July 20. Its carcass was found in the foothills the next day with evidence of a chase on the grassland cliff.
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- India's military prowess and diverse cultural heritage were on display at the 67th Republic Day parade at the Rajpath on Tuesday.
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text:
BioScrip (NASDAQ:BIOS)
Q2 2011 Earnings Call
August 08, 2011 8:30 am ET
Mary Graves - Interim Chief Financial Officer and Treasurer
Richard Smith - Chief Executive Officer, President, Chief Operating Officer and Director
Lisa Wilson - In-Site Communications, IR
Kyle Smith - Jefferies & Company, Inc.
Michael Petusky - Noble Financial Group, Inc.
Brooks O'Neil - Dougherty & Company LLC
Good morning, ladies and gentlemen. Thank you for standing by, and welcome to the BioScrip Second Quarter 2011 Earnings Conference Call. [Operator Instructions] As a reminder, this conference is being recorded, Monday, August 8, 2011. I would now like to turn the conference over to Lisa Wilson, Investor Relations for BioScrip. Please go ahead.
Lisa Wilson
Good morning, and thank you for joining us today. By now, you should have received a copy of our press release issued this morning. If you have not received it, you may access it through the Investor Relations section at our website. Rick Smith, President and Chief Executive Officer; and MJ Graves, Interim Chief Financial Officer and Treasurer, will host this morning's call.
The call may be accessed through our website at bioscrip.com. A replay will be available shortly after the call. Interested parties can access the replay by dialing (800) 633-8284 in the U.S. and (402) 977-9140 internationally and entering access code 21533779. An audio webcast will also be available under the Investor Relations section of the BioScrip website at www.bioscrip.com.
Before we get started, I would like to remind everyone that any statements made on the call today or in our press release that express a belief, expectation or intent, as well as those that are historical facts, are considered forward-looking statements and are protected under the Safe Harbor of the Private Securities Litigation and Reform Act. These forward-looking statements are based on information available to BioScrip today, and the company assumes no obligation to update such statements as circumstances change.
These forward-looking statements may involve a number of risks and uncertainties, which may cause the company's results to differ materially from such statements. Forward-looking statements are subject to inherent risks and uncertainties surrounding future expectations generally and may differ materially from actual future experience. Risks and uncertainties that could affect forward-looking statements include the failure to realize annual cost savings associated with any restructuring or cost-reduction efforts, the impact of members of management in executing these efforts, our ability to leverage core competencies or maximize margins and operating cash flow and the risks described from time to time in the company's report filed with the SEC, including the company's Form 10-Q for the period ended June 30,2011 and annual report on Form 10-K for the year ended December 31, 2010.
In addition, as required by Regulation G, reconciliation of non-GAAP financial measures mentioned during our call today most comparable to GAAP financial measures can be found in Schedule 4 of today's press release. That schedule is available as well on our website under the link to News found in the About Us section of our homepage at bioscrip.com.
And now I would like to turn the call over to Rick Smith. Rick?
Richard Smith
Thank you, Lisa. Good morning, everyone. Thank you for joining today's call. In the second quarter, we continued to execute on key elements of our strategic plan and to improve our competitive position as a national provider of Infusion and Pharmacy Services.
Our second quarter adjusted EBITDA increased to $18.1 million versus $16.6 million during the first quarter, an increase of 8.7%. Sequential revenue increased from $439.3 million to $441.4 million, which reflects $12.9 million of sequential revenue growth, as we replaced $10.8 million of Q1 revenue represented by the discontinuation of $5.4 million of lower margin business in our Pharmacy Services segment, as well as $5.4 million relating to the completion of the Synagis season. We continue to reduce expenses in targeted areas, generate positive operating cash flows and reduce our bank debt another $4 million.
MJ will provide more detail on the financial results. However, I'd like to highlight a few key items. Revenue increased $29.4 million or 7.1% year-over-year. This includes an 8.8% increase in Pharmacy Services and a 2.5% increase in Infusion/Home Health. Adjusted EBITDA was relatively flat at $18.1 million, as compared to $18.4 million in the prior year. It grew from $16.6 million in the prior quarter.
Net loss for the quarter was $2.3 million but this included $3.9 million in restructuring charges and $4.8 million, in connection with an agreement in principle with the United States Attorney's Office in Minneapolis. Before giving effect to these 2 items, earnings per share was $0.10 per share.
Regarding Infusion/Home Health, we're pleased to see the transformation to a national provider taking place. We are seeing year-over-year patient volume growth, as well as consistent revenue growth in the therapies we are targeting. Offsetting this is the anticipated rationalized pricing declines related to shifting patients from out-of-network to contracted relationships. We also discontinued $2.2 million of prior year Infusion revenue due to unacceptable pricing levels. Taking this into account, our organic infusion growth was 6.3%.
The Home Health industry was impacted by the 2011 cut in Medicare reimbursement and the new face-to-face requirement. However, given that our Medicare Home Health exposure is less than 2% of consolidated revenue, the impact for us was not significant. For the quarter, compared to prior year, the impact of these 2 changes was $1.1 million; $500,000 related to reimbursement cut, and $600,000 related to a census disruption. Our Home Health team is looking to mitigate the impact of these changes with an increase in patient census and improved operating efficiencies.
Operating expenses in the second quarter were up $4.9 million over the first quarter. This is primarily due to the $4.8 million charge, in connection with an agreement in principle with the United State's Attorneys Office in Minneapolis. The matter primarily involved issues related to incomplete reimbursement documentation and delays in resolving overpayments made to us by the government and due back to the government.
Under the agreement in principle, the government including Medicare and all Medicaid agencies, will release the company from all liability relating to the matters at issue. We're pleased to have reached the resolution, ensuring that our compliance culture, training, practices and procedures are effective and of the highest priority everyday at BioScrip. Importantly, the resolution of this legacy issue allows us to move forward without distraction or further liability.
Switching gears to our strategic assessment. Restructuring efforts continued unabated in the second quarter. We realized an additional $3 million in annualized restructuring savings this quarter versus the last. We expect to realize additional cost reductions in the second half through a rationalization of our facilities. We also anticipate a lower level of restructuring expenses pursuant to our initial plan, the second half of this year, as a substantial percentage of the actions have been completed.
Our primary strategic focus at BioScrip has not changed. Driving profitable organic revenue growth throughout the company, increasing our operating cash flow generation levels and reducing our debt. We also look at selected acquisitions to expand our footprint. Our ability to achieve strong new patient census comes from our excellent sales, clinical services, reimbursement and operations teams. As we head into the second half of the year, we strive to continue expanding our referral relationships and patient census levels.
With that, I will turn it over to MJ, who will take you through additional details on the financials for the quarter.
Mary Graves
Thank you, Rick, and good morning. For the quarter, we reported revenue of $441.4 million compared to $412 million from the same period a year ago, an increase of $29.4 million or 7.1%. Infusion/Home Health services revenues for the second quarter was $109.3 million compared to $106.7 million in the prior year. An increase of $2.7 million or 2.5%. Pharmacy Services revenue for the second quarter was $332.1 million compared to $305.4 million for the prior year, an increase of $26.7 million or 8.7%.
For the second quarter, gross profit increased to $76.2 million compared to $73.5 million in the prior year, an increase of $2.7 million or 3.7%. The company's gross profit margin decreased to 17.3% from 17.8% in the prior year, primarily as a result to the changes in the patient mix and movement of certain out-of-network patients to contracted relationships.
SG&A for the quarter was $57 million, down from $59.1 million in the prior year, primarily due to the reduction in employee costs and other savings achieved through the efforts of our restructuring program. Operating expenses increased by $11.7 million from $60 million in the prior year to $71.7 million in the current year.
As Rick mentioned, we recorded a $4.8 million charge related to the settlement with the U.S. Attorney's Office in Minneapolis. In addition, we incurred $3.9 million in restructuring charges, consistent with the progress of our strategic assessment. The company's income from operations, including the effect of the restructuring and legal settlement charges, was $4.5 million compared to $13.5 million in the prior year.
For the second quarter, interest expense was $7.2 million compared to $8.2 million in the prior year. The lower year-over-year interest expense reflects the company's refinancing activities in December 2010.
Net loss for the second quarter was $2.3 million or $0.04 per share compared to $3.1 million or $0.06 per diluted share in the prior year. Excluding the $8.7 million impacts of legal settlement and restructuring charges, net income was $5.5 million or $0.10 per diluted share.
During the second quarter of 2011, BioScrip generated $25 million of segment adjusted EBITDA or 5.7% of total revenue compared to $26.3 million or 6.4% of total revenue in the prior year. Fusion Home Health generated $10.9 million of segment adjusted EBITDA or 10% of our related revenue. The Pharmacy Services generated $14.1 million of segment adjusted EBITDA or 4.2% of related revenue.
On a consolidated basis, BioScrip reported adjusted EBITDA of $18.1 million or 4.1% of total revenue compared to $18.4 million or 4.5% of total revenue in the prior year.
Turning now to our cash flows. Net cash generated from operating activities in the second quarter totaled $6.7 million compared to $500,000 of cash provided by operating activities in the prior year.
From a balance sheet perspective, we continue to have the financial flexibility to support future cash flow priorities and are in compliance with all of our debt covenants. Our total borrowings under the revolving credit facility had decreased from $81.2 million at year end to $48.1 million, as of June 30, 2011.
To give you an update on the progress of our strategic restructuring, I'm going to highlight a few key items. On a sequential basis, BioScrip reported adjusted EBITDA of $18.1 million or 4.1% of revenue versus $16.6 million or 3.8% of revenue in the prior quarter.
Operating expenses increased from $66.8 million to $71.7 million, reflecting the restructuring and settlement charges noted earlier. Excluding the restructuring and legal settlement charges, operating expenses represented 14.3% of revenue in the current quarter, as compared to 14.9% in the prior quarter.
We continue to improve the quality of our receivables, with the decrease in accounts receivable days outstanding from 42.3 at December 31, 2010, to 41.8 at June 30, 2011.
In the first quarter, we've realized a $23.6 million reduction in inventory, as a result of certain supply chain process improvements. In the second quarter, an additional $2.4 million in inventory reduction was achieved.
I will now turn the call back over to Rick.
Richard Smith
Thanks, MJ. Overall, we are pleased with our results and the progress we've made this quarter, and we look forward to realizing the benefits of our continued implementation of our strategic plan. We believe we are -- have the right strategy in place and have a bright future ahead of us over the coming quarters. We look to continue to grow our business and rightsize our cost structure.
With that, I'd like to open up the call for questions. Operator?
Question-and-Answer Session
[Operator Instructions] Our first question comes from the line of Brooks O'Neil from Dougherty & Company.
Brooks O'Neil - Dougherty & Company LLC
I have a couple of questions. I guess, first, I'd like to start off with, could you refresh our memory about the benefits of moving from out-of-network to in-network? Obviously, you're seeing some decline in reimbursement, which, at least, on paper, doesn't seem positive. So what's going on there?
Richard Smith
Within out-of-network means you don't have a contracted relationship, so the availability of patient census on an ongoing basis is limited. And also, I think, from a -- what we've seen also is from a payer perspective, a desire to eliminate out-of-network providers and essentially move all of their patients and services into contracted providers wherever possible. And so a number of our -- the legacy businesses, on both sides of the house prior -- essentially had substantial out-of-network relationships. And so for the strength and opportunities to continue to grow this business for many years, we essentially tucked a number of our locations into contracted relationships.
Brooks O'Neil - Dougherty & Company LLC
So that -- the United, the Aetna, the Humana. Those kinds of things?
Richard Smith
Brooks O'Neil - Dougherty & Company LLC
Okay. Secondly. I guess, you clearly pointed to optimism regarding the second half of the year, which frankly, I share. But you would you mind -- I mean, obviously, some of it was contained in your prepared remarks, but what are some of the big things that you'd say, give you some reasons for optimism for the second half?
Richard Smith
I think, what we're seeing is good progress. Clearly, there are different pockets of headwinds, as we talked about. But I think the fact that we are in these contracted relationships, the opportunities for access to members and continued census, we believe, if we continue to execute, will bode well for us in terms of our organic growth in patient census levels. I think the strength in the Pharmacy Services side reflects a lot of work that has been done over the last couple of years, in terms of getting part of that business into direct managed care relationships as well, and so we're seeing the positive effects there. We've seen some good organic growth in targeted areas with the Infusion business. And that work needs to continue to occur. And we believe that we have some good opportunities to continue to build on the first half of this year.
Brooks O'Neil - Dougherty & Company LLC
Good. And I guess, if I understand it correctly, we're beginning to see some of the benefits of some of the cost-reduction efforts you've had, but we might see a little bit more of that in the second half as well?
Richard Smith
Yes. As we talked about the -- a number of the initiatives that were identified, essentially occurred in late Q1 and into Q2. We also have other costs that we expect to see, primarily from the rationalization of the corporate space that we had talked on the last call. Offsetting this is some investments in the field related to services and physicians to service the high levels of patient census. So we do have some investments also in our managed care organization that I talked about in prior quarters as well. But as it relates to the targeted cost reductions, we're very much on plan with those items that we had identified. And we expect to continue to evaluate all areas of the company, as we've said before. That essentially, as we look at the patient revenue generation, patient service, cash collections and other areas critical to continue to grow the business.
Brooks O'Neil - Dougherty & Company LLC
Great. And then MJ mentioned that it's likely we'll see reductions in any restructuring charges in the second half. I mean, generally speaking, can you give us just a feel for sort of the order of magnitude we should expect in that area in the second half?
Mary Graves
Well, we had more in consulting fees as a component of the restructuring charges, Brooks, in the first half of the year. As you'll see in the quarterly filing that we'll make tomorrow, on a year-to-date basis, we've had $5.2 million in restructuring charges, and over 1/2 of that, $2.7 million, was in consulting fees. We also had about $1.5 million in severance and about $1 million in other expenses. So those costs, like the consulting, the biggest piece of that, we've completed that part of it. As Rick mentioned, we will have some facility rationalization cost in the second half of the year, and we may have a little bit more in severance charges. But the biggest pieces of that, we probably incurred. These consultants, they always charge you so much. Speaking as a consultant, I can throw that out there.
Brooks O'Neil - Dougherty & Company LLC
There you go. All right. One last question. I appreciate the additional insights. Obviously, one thing investors are worried about is reimbursement pressures, particularly in government programs. Can you just summarize what you see in terms of the reimbursement outlook for say, the next 6 months or so?
Richard Smith
I think, yes, in the Home Health, it's pretty wide public -- widely publicized, but as we stated is -- the Home Health impact related to the overall consolidated revenue is a small percentage. And while we've -- clearly, we've been impacted slightly by those changes. We believe that -- and there's been some disruption from the face-to-face. We believe that there's opportunities to improve and increase census. And we -- continually, we look at our operating structures within that segment of the business. And so I think that sort of -- I think there's more on plan potentially for next year in that area, offset by the demographics that are coming away of the industry. I think in the rest of the businesses, we're seeing opportunities in the Infusion side. Legislation's been reintroduced to cover the full Medicare Infusion benefit. And so hopefully, that can bode well for the -- going into 2012 or in'10 subsequent years. But I think given where pressures are on hospitals and other areas, opportunities to drive them into Homecare, we believe, still, is very strong, given our lowest cost of service, but also high levels of clinical capabilities and programs that essentially can be effective in servicing the pressures building in the government.
Our next question is from the line of Kyle Smith from Jefferies.
Kyle Smith - Jefferies & Company, Inc.
Rick, you just mentioned legislation introduced about the Medicare home infusion benefit. And I know we'd seen that introduced repeatedly over the past years. Is there anything that you're seeing or hearing that would suggest that this might be the year it finally gained some traction and moves forward?
Richard Smith
I think last week, AARP gave a huge boost of support and endorsed the effort. I also think that based on opportunities to demonstrate an effective service model that is in place today is an opportunity for some immediate cost savings and efficiencies without giving up on clinical services and outcomes and patient's quality of life. And so I think that given the budget pressures, the opportunity to push something through in that area, I think, has a higher percentage or probability of success. We, still, as an industry, need to do our grassroots efforts to get the word out and to educate. But I think this might be a good window for -- there might be some success there.
Kyle Smith - Jefferies & Company, Inc.
Okay. Well, best of luck with that. In terms of the calling of unprofitable business, is that something where we've completely moved past the chunky phase, and it's going to just be the day-to-day blocking and tackling of your business and looking for things that may be need to be tweaked? Or should we be anticipating possibly some multimillion dollar additional reductions, as we go forward over the course of 2011?
Richard Smith
I think that there might be a little bit legacy in prior quarters in the prior year. But I think our focus is -- we've called a lot of it sequentially quarter-to-quarter. And so Q1 in the Pharmacy Services side, we had mentioned there's a little bit of a tail, and so the total from Q4 was about $21 million that we had identified that was going to leave. Everything else, we're staying focused on, continuing to build our relationships and position in the Pharmacy Services segment. And then on the Infusion side, we've essentially settled into our contracted relationships, and now the focus is on pull-through and increasing patient census and positioning within each of our markets.
Kyle Smith - Jefferies & Company, Inc.
Okay. Great. And MJ, great work on the working capital front, significant dollars pulled out of inventories. We saw a little bit of incremental here in the second quarter. Are there any areas, as you look out there now, where there's some potential for further gains in working capital, or is that story largely over?
Richard Smith
We'll continue to put a focus on the receivables. We're placing more investment on the front end of the process, which I think, any smart and prudent provider will be trying to do. It's a challenging environment, but we've got great teamwork between operations and the reimbursement team. So we feel like there is more opportunity there. Inventory, we probably have it at its ideal point right now. We have gained quite a bit in operating cash flow from better managing the inventory profits, both in supply-chain initiatives and some system improvement. But I do see more opportunity on the receivables side, and I think we'll see that in the second half.
Kyle Smith - Jefferies & Company, Inc.
Okay, fantastic. And I know you haven't been giving guidance. But at one point, I recall the comment that the path forward wasn't necessarily going to be linear. Yes, there might be some -- I took that as there might be some instances, where we take 2 or 3 steps forward and then one step back. Since the fourth quarter, your EBITDA sequentially improved both in the first and second quarter. Should we -- is there anything we should be aware of to keep from getting ahead of ourselves and setting expectations for the third and fourth quarter? Or do you feel that you really got the wind at your backs right now?
Richard Smith
Our focus is really on continuing to execute on our plan, and so our objective is to continue to make the progress in a steady fashion. The opportunities we see is if we can continue to execute and make the progress that we've made the first 2 quarters, then I think we'll continue to make progress the rest of the year. And so we're still executing parts of our strategic assessment, strategic plan and those pieces, and so we're very much focused on sequential improvement and also dealing with the challenges that are thrown at us, as well.
Kyle Smith - Jefferies & Company, Inc.
Okay. Good luck with that. Last question for me. I noticed that you added a breakout of products versus services revenues in the earnings release. I don't think it got much focus in the prepared remarks. Is there anything that we should be focusing in on that? Should we expect to see that breakout going forward? And how should we be thinking about the dynamics between those 2 lines in each of your segments?
Mary Graves
You will be getting that going forward. The reason we did it this period is because we triggered the 10% threshold, which requires the breakdown between the product and the service revenue. It's a little challenging in our business to do that classification from the standpoint. So much of the reimbursement we get, it can be per diem, it can be a lump sum reimbursement, what have you. I think, probably the initial few quarters, I would begin to pay attention to that and monitor it as we go throughout the year. But from our standpoint, we really continue to put the focus on both the total gross profit margin that we receive from the various funds of therapy but also the contribution margin. So we don't hone in and focus as much specifically on the product versus the service component, because in some cases, it could be, as you know this in Pharmacy, you may have a 1% or 2% gross profit margin on certain products, but it could be that you have a 18% or 20% gross profit margin on the related service. So that's why we don't put too much emphasis on that.
And our last question is from the line of Mike Petusky from Noble Financial.
Michael Petusky - Noble Financial Group, Inc.
A few questions. I guess, in terms of the -- you spoke about rationalization of Pharmacy and also the corporate space, I mean, are those Q3 events, second half events? And do you have that dialed in any more than just that is coming?
Richard Smith
Yes -- no, it's actually really the corporate facilities we have talked about, so it wasn't Pharmacy. So it's primarily the corporate facilities that we had talked about in prior calls. And so I think, we -- our expectations is that we will get out of at least one and potentially 2 of our 3 corporate locations by the end of the third quarter. And so you'll most likely see that come through in Q3, to the extent that we're able to vacate those. And so that is, essentially, what we're talking about in terms of rationalization. Also, in the quarter, we returned some square footage back to the landlord in our Eden Prairie corporate headquarters too. So just, essentially, re-evaluating the space that we have today in our need and continuing to trim unnecessary cost.
Michael Petusky - Noble Financial Group, Inc.
Okay. All right. I guess, I'm referring on the rationalization process. Okay. So can you talk about, obviously, in the short-term, you may be giving up a little bit in terms of pricing on these national contracts, but can you talk about United and Aetna and Humana? I mean, are these things ramping the way you'd like? Or are they close to ramping the way you like? Or are they kind of lagging?
Richard Smith
I think that, for the most part, they're ramping the way we like. We have some more work to do on one of the payers, it got late in the game but -- so we like the positioning we have in regard to our placement in these plans. And I -- and we've still have more work to do in terms of our competitive positioning. But I think that again the direction is I think to reduce panel providers and -- at the local level and especially the other networks. And so I think being on the national panel provides us a good opportunity for access to members under these contracts.
Michael Petusky - Noble Financial Group, Inc.
And I had hoped you guys might start giving out some disease state data. Do you have anything anecdotally you could share, or as far as which disease states were strong or not strong?
Richard Smith
I think, we didn't have that ready for communication, but I think as we've talked again before on the Pharmacy Services side, our oncology continues to grow in strong 20% level. We've seen some new drugs come on this year in terms of the MS category that has been strong for us. And also, a lot of our growth, as we've talked about, has been driven by some of the new direct managed care relationships we've put in place over last year that has benefited us so far this year, especially the second quarter.
Michael Petusky - Noble Financial Group, Inc.
You think that you guys will start to break that stuff out maybe in the next quarter or 2?
Richard Smith
Yes. We definitely are looking at it. We just -- yes, we've committed to providing that level of additional information. We'll definitely take a look at it.
Mary Graves
Yes, part of the hold back on that, Mike, is really more competitive. So we are evaluating that, and we'll see what we can do.
Michael Petusky - Noble Financial Group, Inc.
Okay. All right. I guess, one of the previous questioners tried to get at this a little bit. But I guess let me ask a more pointed question. Is the expectation internally there that Q3, in terms of top line and Q4 after that will be sequentially higher than Q2? Or that -- or are there things going on inside the business that would make that not the case?
Richard Smith
Yes. I think that gets into guidance. I think that, as we said before, our focus is continuing to execute on our plan and essentially look to continue to grow patient census in areas that we're focused on. And so I think if we continue to make progress the way that we had the first 2 quarters, then I think the rest of the year will result in good shape for us as well. And so clearly, we have, our own internal budget that has some objectives of ours to accomplish, and we -- if that goes off, then I think we'll make some good progress.
I'm showing no further questions at this time. I'd like to turn the conference back to you.
Richard Smith
Okay. Thank you. Thank you, everyone for joining our call today. I'd like to conclude by once again thanking our employees and the entire team at BioScrip for the work that they do everyday, servicing our customers and our patients. And have a good day. Thank you.
Thank you. Ladies and gentlemen, that does conclude the conference call for today. We thank you, all, for your participation, and we ask that you please disconnect your lines. Thank you, everyone, and have a good day.
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Everything in this blog is meant to be taken seriously and is completely unironic.
Thanks Torikake
Posted 01-29-2012 at 10:41 PM by MsSquid
I'm gonna challenge the mahjong club to a tournament, and then I'll really show them!
Posted in UncategorizedViews 828 Comments 1
Total Comments 1
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Serving size Per servingComplete recipe
Calories 1019 Calories from Fat 277
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Sodium 773.4 mg32.2%
Total Carbohydrates 161 g53.8%
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Protein 36 g72.7%
Vitamin A 15.2%
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Iron 48.2%
*Based on a 2000 Calorie diet


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Martin Simon
Professor of Mathematics Education
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Martin Simon's current research focuses on understanding the process by which students develop mathematical concepts through their mathematical activity, and how such learning can be fostered. Simon has also done extensive research on the development of mathematics teachers as they learn to teach mathematics with a conceptual focus. Simon has served as a professor of mathematics education at Penn State University and director of the Summer Math for Teachers program at Mount Holyoke College. He has served as principal investigator on five National Science Foundation projects, and was awarded the Distinguished Research Award by the Association of Teacher Educators in 2000, and a Career Achievement Award by the Penn State University College of Education in 2001. He earned his doctorate in mathematics education from the University of Massachusetts at Amherst in 1986.
Simon's current project, Measurement Approach to Rational Numbers (MARN), continues his research on how students learn mathematical concepts, while developing and researching an approach to teaching fractions and ratios building on measurement concepts.


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Joe Coughlin
Steele's B1G Bowl Projections Too Optimistic
Created on Jul 06, 2013 4:26 PM EST
Steele's B1G Bowl Projections Too Optimistic
Coming off a 10-win campaign and returning plenty of talent, Northwestern should be looked at as a contender for the Big Ten title game. Steele looks like he has them behind Michigan and Michigan State in the Legends Division.
I don't think so.
I think they beat both Michigan and Michigan State at home, while winning four nonconference games and others against Minnesota, Iowa and Illinois. That's nine wins and a possible trip to the Big Ten title game. But it would need help from Nebraska.
I see entry into the Outback Bowl on Jan. 1.


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Partner at Heidrick & Struggles, member of the global CEO & Board of Directors Practice
November 23rd and 24th, 2016
What does Meaning@Work signify?
How does the perception of meaning influence organizational performance?
How does the role of meaningful leadership change in the digital world?
Recent research shows that:
- 87% of the workforce don't perceive their work as meaningful.
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Meaning@Work is an essential root cause of innovation and corporate performance. Digitalization is a massive game-changer in this context, offering huge opportunities as well as pitfalls. Through interaction with an exclusive circle of senior executives and selected young talents, our FLC 2016 speakers will discuss questions such as how to synchronize organizational performance and Meaning@Work.
Where: Future of Leadership Conference 2016 at Tutzing Castle (Evangelische Akademie Tutzing) by Lake Starnberg
When: November 23rd and 24th, 2016
Find out more below.
Conference Trailer & Insights from our Project 2016
Future of Leadership Conference
The vision of MEANING@WORK will be presented to the public for the first time at the FUTURE OF LEADERSHIP CONFERENCE.
The Future of Leadership Conference (FLC) is an interactive English-speaking one-day Think Tank that includes powerful keynote addresses, engaging Leadership Labs and a creative Real-Life Business Simulation. Participants meet in the spirit of global citizenship to investigate and discuss fundamental topics of modern and inspiring leadership.
At the 2016 FLC, internationally renowned thought leaders, top executives and decision-makers and brilliant young minds will come together to interactively explore how the notion of "Meaning Making" impacts an organization's success. This cross-generational and interdisciplinary group will investigate how the creation and perception of purpose in the digital age impacts future leadership across all industries, both in terms of skills and technology.
We look forward to welcoming the following speakers on this year's Future of Leadership Conference.
General ret. Dr. Helge Hansen
Former supreme commander of Allied Forces Central Europe within NATO
entire profile
John Elkington
World authority on corporate responsibility and UN Global Compact Partner
entire profile
Prof. Dr. Martin Högl
Head of the Institute for Leadership & Organization, LMU Munich
entire profile
Stefan Ries
Chief Human Resources Officer and member of the Executive Board at SAP SE
entire profile
(all statements are subject to change)
How do I create meaning as a leader?
- 08:00Registration and Breakfast
- 09:00Welcome and Interactive Experience Journey
- 09:30What is Meaning@Work? And How Does it Drive Organizational Performance?Prof. Martin Hoegl (Head of ILO, LMU Munich)
- 09:50Meaningful Leadership in Digital Times – How Digitalization Changes the Role of ManagementStefan Ries (CHRO and member of the Executive Board at SAP SE)
- 10:10Money or Meaning – Antipode or Lever of Sustainable Profitability?Panel discussion between Stefan Ries (CHRO and member of the Executive Board at SAP SE), Prof. Martin Hoegl (Head of ILO, LMU Munich) and John Elkington (world authority on corporate responsibility)
- 11:00News from the Unicorns: Build Something Meaningful – The Rise of the Mission-Driven Digital BusinessDavid Rowan (Editor-in-chief of WIRED UK)
- 11:20Is Meaning@Work a Root Cause of Digital Innovation?Panel discussion between David Rowan (WIRED UK), Timm Richter (CPO at XING) and selected young talents from CDTM and ESMT
- 12:00Idea Hack: How Can Digitalization Contribute to Meaning@Work?Senior executives will join with young talents to find and develop ideas
- 13:00Lunch
- 14:10Live Business Simulation: What the Hell is Meaning@Work?
- 14:50Learning from Spiritual Wisdom: What You Have to Search for to Discover MeaningFather Dr. Notker Wolf (Abbot Primate of the Benedictine Confederation)
- 15:10Pursuit of Happiness@Work: Appropriate Leadership Goal or Wishful Thinking?Dr. N. S. Rajan (Group CHRO at Tata Sons)
- 15:30Are Meaning Makers the Better Leaders in Digital Times?Panel discussion between Dr. Christine Stimpel (Partner at Heidrick & Struggles), Gen. ret. Dr. Helge Hansen (former supreme commander of Allied Forces Central Europe within NATO) and Dr. N. S. Rajan (Group CHRO at Tata Sons)
- 16:20Meaning@Work: A Breakthrough in the Business MindsetJohn Elkington (world authority on corporate responsibility and UN Global Compact Partner)
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- 18:00Business to Society and Ownership Culture – Making Meaning@Work WorkJoe Kaeser (CEO of Siemens)
- 18:30Dinner
- 20:00Meaningful Leadership Without Any Means: How a Refugee Organization in Uganda is Transforming Its SocietyWith Benson Wereje (CEO of CIYOTA) and Bahati Kanyamanza (COO of CIYOTA)
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Following a new old tradition we will meet at the Evangelische Akademie Tutzing, a place of peace and strength next to the beautiful Lake Starnberg in the Bavarian Alps.
Participants get the chance to take a step back from day-to-day challenges, calm down and discover why and how to "Make Meaning" of their work.
Learn more about the Evangelische Akademie Tutzing:
The Award
The Future of Leadership Award was born from the conviction that breakthrough ideas driven by exceptional people sometimes really can change the world.
In an open and democratically run vote following extensive discussion of candidates, students identify each year the top 3 Thought Leaders whose ideas influenced the minds and actions of an entire generation. Like the previous years, the winner of the Future of Leadership Award will be honored at the Future of Leadership Conference gala evening.
Last year, Jimmy Wales, the founder of Wikipedia was awarded this prize.
Thought Leaders
Similar to previous years, a dedicated team of FLI associates spoke with prominent and diverse thought leaders and decision-makers from industry, politics and academia to discover more concretely: What key daily practices and situations create – and on the other hand destroy – meaning and motivation in today's organizations, particularly in the digital age?
This year, we already had the pleasure of speaking to great minds like Siemens CEO Joe Kaeser, Peter Michael Senge from MIT Sloan School of Management, who is president of the Society for Organizational Learning, Martina Koederitz, CEO of IBM Germany, Prof. Götz Werner, founder and board member of the dm-drogerie markt, Yale Professor Amy Wrzesniewski, who is one of the leading global researches on meaning, TED senior fellow and columnist at New York Times, Professor Barry Schwartz, General ret. Dr. Helge Hansen, former commander-in-chief of the Allied Forces Central Europe of the NATO, Saskia Thais Bruysten, co-founder of Yunus Social Business and Benson Wereje, former child soldier in Kongo and today social business entrepreneur striving to transform the African Society.
Prof. Amy Wrzesniewski
Professor of Organizational Behavior at Yale School of Management
entire article
Prof. Barbara Kellerman
Professor of Public Leadership at Harvard University's John F. Kennedy School of Government
entire article...
Father Dr. Notker Wolf
Abbot Primate of the Benedictine Confederation of the Order of Saint Benedict
entire article...
Benson Wereje
Co-founder and CEO of CIYOTA; refugee from Democratic Republic of Congo
entire article...
Prof. Peter Senge
Senior Lecturer of Behavioral and Policy Sciences at MIT Massachusetts Institute of Technology
entire article...
Future Lab
The intellectual input of the thought leaders provided the fundament for the interactive workshop among selected business representatives and compiled graduates and alumnis. Facilitated by the MLI Leadership Institute, they developed a common understanding of and future scenario for MEANING@WORK – LEADERSHIP IN TIMES OF DIGITALIZATION. Same as every year, this workshop as central part of the research project unleashed the attending people's knowledge-pool by an alternation of individual reflection, group breakouts, plenary discussion and voting, following a design-thinking structure.
The outcome of the Future Lab is a unique Vision of Meaning Making that features the most important levers through which leadership can influence MEANING@WORK. The findings of the participants will be documented as a remarkable learning map on Meaning Making that will be presented at the next Future of Leadership Conference in November 2016.
The FUTURE LAB on MEANING@WORK took place on January 23rd at the Ludwig-Maximilians-Universität in Munich.
The results of the FLI research project on MEANING@WORK will be presented to the public and discussed among young talent and senior representatives from the economic, public and political sector during the next Future of Leadership Conference on November 24th, 2016. This Think Tank is a unique blend of minds, representing a diversity of perspectives from all over the world, bringing the academic world and the experiences of practitioners together.


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Since its introduction to the Commonwealth Games in 1998, Sevens has played a key role in each of the Games it has featured in. Crowds have packed the stadium and the action has been fast and furious, bringing a new dimension to the list of established events.
The success of Sevens as a Commonwealth Games sport has helped it gain Olympic status for 2016 when it will make its debut in Rio.
It sets the sport a challenge to enrapture and entertain a host nation not familiar with the oval-ball game, to convince the International Olympic Committee that it should be retained for future Games.
Here are the lessons Rio can take from the Glasgow tournament to make Sevens a success.


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Surfside Travel Guide
Photos from SurfsidePictures of Surfside (83)
Hotel Deals in Surfside
Hotels in SurfsideSurfside Accommodations (5)
Solara Surfside Resort
8801 Collins Ave, Surfside, United States
Coronado Hotel Surfside
9501 Collins Ave, Surfside, United States
Hilyard Manor Motel Surfside
9541 Collins Ave, Surfside, United States
Lilypad Suite Hotel Surfside
9400 Collins Ave., Surfside, United States
Travel Blogs from SurfsideSurfside Travel Blogs (14)
Shopping Day
Today our quest was to locate the best value on the appliances we will need for the new house. A washer, dryer and fridge are needed and so the battle begins. Gail has unbelievably agreed to cut back on her desire for only top of the line units for ...
... at McDonald's, and southward we drove. A L L D A Y!! We made up our minds yesterday to stay on I95 to Surfside instead of heading straight home. Our plan was to surprise my entire family who was already there for the holiday weekend. Oddly enough, ...
Miami bitch
"Kathy beat the shit out of him" Gigi talking about passport Dan "Kathy throwing back drinks last night. I'm fucking Kathy Lee" Matt making fun "I have a condom if you need it!" GG being funny about going to pub crawl and getting action "Happiness is ...
Restful Day!
Had a great sleep! Uncle Bob made awesome waffles - I had Aunt Joan take a picture since Dad's camera was in the RV but she forgot her cable at home as she figured she wouldn't be putting pictures on her computer - so imagine - a beautiful, warm ...


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Fort Stevens, Rock Creek Park
NPT Protects Critical Historic Property
"In our search to find an organization that understands and shares our interests, we found the National Park Trust. NPT was willing to act to keep this history intact." - Patricia A. Tyson, Secretary, Military Road School Alumni Association
Citizen Land Conservancy Buys Critical Historical Property in the Nation's Capital
WASHINGTON, DC - The National Park Trust (NPT) announced today the purchase of a critical property located at Fort Stevens, which is part of Rock Creek Park, a unit of the national park system.
"This 'missing link' will add several pieces of America's history and needed inner city open space to the National Park Service (NPS)," said Paul C. Pritchard, President of NPT.
The property is located a few feet away from where President Lincoln witnessed Confederate Troops marching toward the Capital. This is the only recorded incident of a U.S. President exposed to enemy fire while in office.
The acquisition will also help protect the Military Road School, one of the historic schools for African-American children during the era of segregated education.
Fort Stevens is part of the nation's largest urban unit of the NPS. It was slated for development into townhouses. At the last minute NPT was able to purchase the property from the developer and a local group that owned the property. NPT is holding the property until the NPS is able to purchase it.
"Preserving the cultural heritage of the Nation's Capital is important because it reflects the strength, valor, dignity and courage which have made our nation great," said Patricia A. Tyson, Secretary, Military Road School Alumni Association. "In our search to find an organization that understands and shares our interests, we found the National Park Trust. NPT was willing to act to keep this history intact."
"This property is a part of the NPT Capital Region Campaign for our nation which now will be added to our parklands", said Paul C. Pritchard, President of NPT. "Although it's a small piece of land it is essential to the history and heritage of our area that are intertwined in Rock Creek Park. Rock Creek is not only a geological resource but includes great sculpture work, civil war history, African-American history and other qualities that were envisioned as a critical part of this unique national park."
The National Park Trust is the only private land conservancy uniquely dedicated to preserving America's national system of parks, wildlife refuges, and historic monuments.
For more information contact:
National Park Trust (NPT)
(202) 548-0500
- Thanks to your support, 2016 was a record-breaking year for Kids to Parks Day! Watch our KTP Day 2016 summary video.
Since 1983, NPT has supported and assisted in acquiring inholdings and in developing public and private partnerships to promote the acquisition and preservation of parks, wildlife refuges, historic landmarks, public lands, and water ways. We have completed more than 100 park projects benefiting 49 national park units and other public lands in 33 states. To learn more about about our work and how you can get involved, contact Dick Ring, NPT Park Projects Director.
- Buddy Bison® School Program: Because Kids Need Parks and Parks Need Kids
The Buddy Bison school program was created in 2009 to engage diverse children from Title I schools with their local, state and national parks to teach environmental education and the numerous benefits of outdoor recreation. If parks are to survive, the face of those parks must change and under-served communities must have access to these local cultural and environmental resources. More than 80% of the students in the Buddy Bison school program qualify for free or reduced-priced lunch, predominantly in inner city communities. This program has been used in 60 schools across the country in grades pre-K through 8th in public, public charter and private schools across the country (20 states and Washington D.C.).
This experiential learning program enhances existing school curricula throughout the year with emphasis on STEM (science, technology, engineering and math) as well as history, language arts, reading, geography, the arts, and outdoor recreation. Students also learn about the careers of professionals who support our parks-- and the importance of stewarding our public lands. And in addition to bringing kids to parks, we bring parks to kids by arranging schools visits from our many conservation partners.
To learn more about how you can get involved, contact Billy Schrack, NPT Director of Youth Programs.


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Support the Gorillas by signing up as a 2016 member! You will look great in your (ladies or mens style) Polo shirt and Cap! Get VIP access to a reserved area on the members' deck for all senior home games, get special offers and discounts from sponsors, inclusion in MEMBERS DRAW at home games, AND discounts on drinks at the Gorilla Bar.
Golden Gorilla Membership – $550.00 (AUD)*
Support the Gorillas and proudly wear your special club cap and polo shirt, enjoy complimentary food and beverages in the "VIP" area at all QAFL home games, use your Member card to get bar and sponsor discounts!
(*GST included in price, Tax invoice and payment receipt for "Sponsorship of WGAFC" will be emailed to you)


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|Oral histories
|Named Person:
|Oswald Veblen; Oswald Veblen
|Document Type:
|Archival Material
|All Authors / Contributors:
Deane Montgomery; Frederik Nebeker; Albert W Tucker
|OCLC Number:
|Transcript : 16 p.
Montgomery, after completing his Ph.D. at the University of Iowa, spent a year at Harvard and then a year (1934-35) at Princeton. During World War II he returned to Princeton; he taught Army students and worked for a year with John von Neumann. In 1948 Montgomery became a permanent member, in 1951 a professor, of the Institute for Advanced Study. Montgomery describes the atmosphere at Princeton, and Tucker and Montgomery talk at length about Oswald Veblen, who played a large role in the building up of the mathematics department at the university and the main role in the establishing of the School of Mathematics at the Institute. Montgomery discusses the beginnings of the Institute.
User-contributed reviews


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At Marv's Quality Towing Inc in Boulder, CO, we want to make sure you get back to driving in no time. We will tow any vehicle you have, wherever you need it to be taken, whenever you need it to be taken there. We're available to you 24 hours a day.
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The play of the week this week was by Zach Bradshaw, of Damascus High School.
Bradshaw catches the punt, fakes one way and then the other, finds a hole and is gone. He runs 93 yards for a touchdown. The game ended seven to nothing.
© WJLA | Portions are © Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or distributed.
WJLA is the local ABC affiliate for the greater Washington DC area. From our studios in Arlington, VA ABC7 covers national and local news, sports, weather, traffic and culture and carries entertainment and sports programming. WJLA serves Alexandria, Springfield, Annandale, Tysons, Reston, Ashburn, Centreville and Manassas, Virginia and Bethesda, Rockville, Gaithersburg, Silver Spring, Wheaton, Beltsville, Greenbelt, Bowie, College Park, Largo, Crofton, Annapolis, Hyattsville and Takoma Park, Maryland, and all the communities in between.


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Young QB's Shine On College Football's Opening WeekendFans in Alabama, Texas, Georgia and Florida are all pretty happy after getting their first look at their team's new QB's.
Onside Kick Leads Tide to Title Over Clemson, 45-40Nick Saban pulled out all the stops Monday night, and it ended with yet another national title for the Alabama Crimson Tide.
National Championship Game: Alabama Vs Clemson - Five Things To WatchThe Tide seek their 4th title under Saban, the Tigers their first since '81. Here's what to look for in tonight's title game.
National Championship Game: Clemson Vs Alabama PicksCan Deshaun Watson and the Tigers pull the upset against the Tide?
College Football Week 11 Can't Miss GamesThe Big 12 takes the spotlight as a battle of top 15 teams goes down in Waco.
College Football Week 10 Can't Miss GamesThe calendar has changed to November and here come the make or break games.
Verne Lundquist: 'Brandon Harris Is Becoming A Significant Contributor For LSU'SEC on CBS announcer discusses the LSU-Alabama game coming up on Saturday.
Top 5 Wildest Sports Callers Of The Week: September 28th-October 2ndThe Top 5 Sports Callers of the week is a weekly installment from CBS Local Sports that will bring you the wildest callers from across the nation.
This Week In College Football: Opening Weekend Viewing GuideThere's plenty of games to choose from, here's the best to watch in each time slot.
Ravens Sign Top Pick Alabama LB Mosley The Baltimore Ravens have signed first-round draft choice C.J. Mosley, an All-America linebacker from Alabama.
Woodbridge Football Star Announces He Will Attend AlabamaRivals.com's No. 1 ranked college football prospect, a senior at Woodbridge High School, announced today that he plans to attend Alabama University.
College Football Spotlight: Will Alabama, Florida State Reach The BCS Finish Line?Will Alabama be the next and most significant victim of the SEC's internal battle royal? Can Florida State avoid a letdown and represent the ACC in the biggest game of the year? This is what makes college football so interesting.


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Skip to comments.Study Examines Relationship of Vitamin A Pathway to Breast Cancer Tumor Progression
Posted on 01/19/2005 8:14:48 PM PST by Coleus
|It has long been suspected that vitamin A may be linked to cancer prevention. The mechanisms by which this may be happening, however, have yet to be understood. Conversely, scientists have discovered that a malfunction in the way the body processes vitamin A may be the culprit behind the formation of breast cancer.
Vitamin A, or retinol, can be found in a number of food products, such as cod liver oil, milk, eggs and fruits and vegetables; however, too much vitamin A can be toxic to the body.
Vitamin A Processing
If the cells don't get enough vitamin A stored, the retinoic acid receptor doesn't get activated, cells don't differentiate and they can turn cancerous.
Through working with human and mouse breast cells, scientists found that the problem stemmed from the cellular retinol-binding protein I (CRBP-I), which is involved in the process of storing the vitamin. One scientist added, "We found that, in the early stages of tumor formation, if you don't have CRBP or LRAT [another protein] to store the retinol, it's likely the receptors will not work in a normal way. This means that cells can't differentiate, and therefore start to proliferate into tumors."
Journal of the National Cancer Institute January 5, 2005;97(1):1
Journal of the National Cancer Institute
Reduced expression of a protein that regulates the metabolism of vitamin A may contribute to tumor progression in breast cancer, according to a new study in the January 5 issue of the Journal of the National Cancer Institute. The study raises the possibility that this vitamin A pathway is a potential target for breast cancer prevention.
Defects in vitamin A, or retinol, bioactivity may be a possible contributor to human carcinogenesis because vitamin A is required for activation of the retinoic acid receptor (RAR), which induces differentiation of adult epithelial cells. One of the characteristics of epithelial cancers is the loss of differentiated attributes. It has been hypothesized that vitamin A bioactivity in cancer cells may be compromised at the level of retinol metabolism, which is regulated by a number of proteins, including cellular retinol-binding protein I (CRBP-I). A study of CRBP-I in mice demonstrated that the protein plays an essential role in vitamin A storage. In addition, CRBP-I expression is down-regulated in about a quarter of human breast cancers. However, it is not known if reduced CRBP-I function compromises vitamin A bioactivity and, if so, whether such a reduction in function would lead to a loss of differentiation and tumor progression.
To determine whether there is a link between retinol storage, RAR activation, and CRBP-I function in the development of breast cancer, Eduardo F. Farias, Ph.D., of Mount Sinai School of Medicine in New York, and colleagues studied RAR activity, retinol storage, CRBP-I localization, and cell differentiation in human and mouse mammary epithelial cellswhich can be used as a model of breast cancerthat expressed normal or mutant CRBP-I.
They found that, in the cells, RAR activation was dependent on CRBP-I-mediated retinol storage, and downregulation of CRBP-I compromised RAR activity, leading to loss of cell differentiation and tumor progression. The authors also observed that the breast tumors derived from these cells that expressed normal CRBP-I regressed, whereas those that did not express CRBP-I continued to grow.
"Our in vivo data suggest that somatic CRBP-I loss of function results in a local deficit in vitamin A storage and metabolism that has profound consequences for the affected tissue, despite presumably normal circulating levels of vitamin A," the authors write. "The consequence of deficient vitamin A storage is a fundamental point that needs to be studied further, but if CRBP-I is indeed essential..., then epidemiologic studies attempting to correlate human vitamin A status with cancer incidence may have been partly misguided."
In an editorial, Reuben Lotan, M.D., of the University of Texas M. D. Anderson Cancer Center in Houston, discusses the role of retinoids in normal development and suggests future research strategies to determine how retinoids may prevent tumor formation and growth of both hormone receptor-positive and -negative breast cancers.
Coalition on Abortion/Breast Cancer
Breast Cancer Prevention Institute
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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issue of racism
heightened racial tensions at OSU
Oregon can claim its own noose spotting.
noose was spotted in front of a Phi Gamma Delta fraternity house at OSU
series of racist antics
The Daily Barometer
wear all black and paint their faces in order to show their school spirit.
ignorant and racist.
refused to run any opinion editorials opposing the "blackout" in the paper.
protest condemning these recent events
ov. 10, at 6:30 pm at Reser Stadium before the OSU-UW football game that night.


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