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Biology Theses and Dissertations
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Mates, John William Benson (University of Oregon, August , 1973)[more][less]Mates, John William Benson 2016-05-27T22:44:40Z 2016-05-27T22:44:40Z 1973-08 http://hdl.handle.net/1794/19922 229 pages en_US University of Oregon Creative Commons BY-NC-ND 4.0-US Chameleonidae Chameleomelleri visual sensory processing saccadic behavior visuomotor processing saccadic patterning Patterning of Eye Movements in the Chameleon Thesis / Dissertation
Fowler, Daniel (University of Oregon, February 23, 2016)[more][less]Herman, Victoria Fowler, Daniel 2016-02-24T00:29:51Z 2016-02-24T00:29:51Z 2016-02-23 http://hdl.handle.net/1794/19718 Functional characterization of synaptic proteins is often precluded by compensation not only among converging signaling pathways but also between structurally and functionally similar genes. One such gene family, the synaptic cell adhesion molecules (SynCAMs), contains four nearly identical members of which SynCAM1-3 are highly localized to excitatory synapses. SynCAMs have been demonstrated to have a clear synaptogenic potential when ectopically presented, either artificially or by overexpression, to developing neurons both in vitro and in vivo. Despite these observations, conflicting reports from gain- and loss-of-function experiments prevent the development of a cohesive functional model for SynCAMs in excitatory synapse formation. To overcome potential SynCAM functional redundancy and simultaneously compare effects of SynCAM knockdown and overexpression in cultured rat hippocampal neurons, I developed a tool for efficient multi-gene knockdown using artificial microRNAs. I then applied this tool with a novel analysis method which I call Mosaic Expression with Differentially Localized Reporters (MEDLR). Using MEDLR, I uncover novel synaptic phenotypes due to SynCAM1-3 knockdown which suggest SynCAM1-3 function redundantly through postsynapse-specific mechanisms to regulate excitatory synapse number and size. This dissertation contains both published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. The SynCAM Family of Cell Adhesion Molecules Function Redundantly to Shape the Excitatory Synapse Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Overcoming the Current Limitations of Next-Generation Sequencing with New Methods for Local Assembly of Genomes and High-Specificity Rare Mutation DetectionPreston, Jessica (University of Oregon, February 23, 2016)[more][less]Phillips, Patrick Preston, Jessica 2016-02-24T00:23:08Z 2016-02-24T00:23:08Z 2016-02-23 http://hdl.handle.net/1794/19700 The relatively low cost of Next-Generation Sequencing (NGS) has enabled researchers to generate large amounts of sequencing data in order to identify disease-causing mutations and to assemble simple genomes. However, NGS has inherent limitations due to the short DNA read lengths and high error rate associated with the technique. The short read lengths of NGS prevent the assembly of genomes with long stretches of repetitive DNA, and the high error rate prevents the accurate detection of rare mutations in heterogeneous populations such as tumors and microbiomes. I have co-developed new NGS methods to overcome these challenges. In order to increase the effective read length of NGS reads, local de novo assembly of short reads into long contigs can be achieved through the use of Paired-End Restriction-site Associated DNA Sequencing (RAD-PE-Seq). With the RAD-PE method, I sequenced a stickleback fosmid and generated contigs with an N50 length of 480 nucleotides. In order to eliminate false-positive mutations caused by the high error rate of NGS, the Paired-End Low Error Sequencing (PELE-Seq) method was developed, which uses numerous quality control measures during the sequencing library preparation and data analysis steps in order to effectively eliminate sequencing errors. Control testing of the PELE-Seq demonstrates that the method completely eliminates false-positive mutations at sequencing read depths below 20,000X coverage, compared to a ~20% false-positive rate obtained with previous methods. The high accuracy of the PELE-Seq method allows for the detection of ultra-rare mutations in a genome, which was previously impossible with NGS. This dissertation includes previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. blood biopsy evolutionary biology genetic heterogeneity minor alleles Next-generation sequencing Single nucleotide polymorphisms Overcoming the Current Limitations of Next-Generation Sequencing with New Methods for Local Assembly of Genomes and High-Specificity Rare Mutation Detection Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Klein, Ann (University of Oregon, February 23, 2016)[more][less]Bohannan, Brendan Klein, Ann 2016-02-24T00:14:06Z 2016-02-24T00:14:06Z 2016-02-23 http://hdl.handle.net/1794/19676 Microorganisms are critical to the functioning of terrestrial and aquatic ecosystems and may also play a role in the functioning of the atmosphere. However, little is known about the diversity and function of microorganisms in the atmosphere. To investigate the forces driving the assembly of bacterial microbial communities in the atmosphere, I measured temporal variation in bacterial diversity and composition over diurnal and inter-day time scales. Results suggest that bacterial communities in the atmosphere markedly vary over diurnal time scales and are likely structured by inputs from both local terrestrial and long-distance sources. To assess the potential functions of bacteria and fungi in the atmosphere, I characterized total and potentially active communities using both RNA- and DNA-based data. Results suggest there are metabolically active microorganisms in the atmosphere that may affect atmospheric functions including precipitation development and carbon cycling. This dissertation includes previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. atmosphere bacteria biodiversity fungi microorganism Microbial Biodiversity of the Atmosphere Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Investigating Roles of the Brg1-Associated Factor (BAF) Chromatin Remodeling Complex during Mammalian Heart Valve DevelopmentAkerberg, Brynn (University of Oregon, February 23, 2016)[more][less]Herman, Victoria Akerberg, Brynn 2016-02-24T00:12:06Z 2016-02-24T00:12:06Z 2016-02-23 http://hdl.handle.net/1794/19672 The integration of chromatin regulation into the gene regulatory networks that progressively transform endocardial cushions into highly structured valves is poorly understood. To investigate contributions of chromatin remodeling to valve development, we use two endocardial Cre lines to conditionally delete floxed Brg1, the core subunit of the Brg1-associated factor complex. In an early-deleting Tie2:Cre model, loss of Brg1 disrupts endocardial-mesenchymal transformation (EMT) in both the proximal outflow tract (pOFT) and atrioventricular canal (AVC) cushions. EMT appears to initiate normally in the absence of Brg1, but endocardial cells fail to switch from an epithelial to mesenchymal gene expression program. In a later-deleting Nfatc1Cre model, Brg1-deficient mice develop thickened, malpatterned and frequently bicuspid semilunar valves while showing normal AVC-derived valves. Fate mapping experiments demonstrate that the enlarged semilunar valves result from an expansion of non-Nfatc1Cre-lineage mesenchyme. Paradoxically, until E14.5, these same embryos have smaller semilunar valves, originating from a moderate deficiency of pOFT EMT. Depletion of this mesenchyme sub-population precludes formation of the valves' base and hinge regions and disrupts growth regulatory networks, causing the valves to progress to a diseased state. RNA-seq of E14.5 Nfatc1Cre;Brg1F/F cardiac cushions identifies novel transcripts that may coordinate cellular interactions that direct growth and patterning stages of semilunar valve development. We propose that early disruption of EMT in the pOFT is sufficient to trigger secondary responses that culminate in commonly observed valve phenotypes in both mouse genetic models and human disease. This dissertation includes previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Investigating Roles of the Brg1-Associated Factor (BAF) Chromatin Remodeling Complex during Mammalian Heart Valve Development Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
The Influence of Behavior and Hydrodynamics on the Dispersal of Dungeness Crab, Cancer magister, LarvaeRasmuson, Leif (University of Oregon, February 23, 2016)[more][less]Roy, Barbara Rasmuson, Leif 2016-02-24T00:11:39Z 2016-02-23 http://hdl.handle.net/1794/19671 The Dungeness crab fishery is the most economically important on the West Coast; however, it has experienced dramatic fluctuations in annual catch. Previous research has shown the annual catch of megalopae is correlated with the commercial catch. The catch of megalopae is correlated with the phase of the Pacific Decadal Oscillation (PDO), the day of the year of the spring transition and the amount of upwelling following the spring transition. Further, the daily catch of megalopae is correlated with the internal tide. We developed individual based models of Dungeness crab dispersal, which we validated with results from a light trap. We demonstrated that the retention of larvae in the California Current is enhanced during negative phase PDOs. Further, we suggest that larvae migrate to or almost to the bottom each day. Specifically, megalopae exhibit a twilight vertical migration off of the continental shelf and remain in the neuston on the continental shelf. This concentrates megalopae at the continental shelf break. We also observed megalopae in situ and demonstrated that they swim in the neuston with the surface current at speeds of ~ 10 cm s-1. Using these results and data from a mooring, we demonstrated that this behavior would increase the distance internal waves would transport larvae. We analyzed mooring data and suggest that catch of megalopae is greater when the thermocline is deep and weak and there is less horizontal shear. We hypothesize this allows internal waves to remain coherent longer on the continental shelf. We show that the spring transition coincides with a shallowing of the thermocline, which would ultimately lead to the development of internal waves of depression rather than elevation. We hypothesize that the change in surface flow, based on whether the wave is one of elevation or depression, explains why most megalopae are caught following the spring transition. In general, these findings help us better understand the dispersal of Dungeness crabs. We suggest the dispersal patterns support Michael Sinclair's member vagrant hypothesis. Further, we suggest these findings apply to many of the continental shelf species in the California Current. This dissertation includes both published and unpublished co-authored materials. en_US University of Oregon All Rights Reserved. Cancer magister dispersal Dungeness crab internal wave larval dispersal model The Influence of Behavior and Hydrodynamics on the Dispersal of Dungeness Crab, Cancer magister, Larvae Electronic Thesis or Dissertation 10000-01-01 Ph.D. doctoral Department of Biology University of Oregon
Della Iacono, Christina (University of Oregon, August 18, 2015)[more][less]Niell, Cris Della Iacono, Christina 2015-08-18T23:07:11Z 2015-08-18T23:07:11Z 2015-08-18 http://hdl.handle.net/1794/19290 By understanding the biological mechanisms of food choice—a behavior that strongly impacts the evolutionary fitness of animals, from worms to humans—we can begin to understand the biological underpinnings of decision making in general and use such knowledge to better understand how this faculty fails in addiction, mental illness, and other disorders. Here, we analyze food choice in Caenorhabditis elegans, a convenient, genetically tractable organism. We describe how prior experience with high and low quality foods alters future food choice in three strains (N2, ceh-36, HW). We also provide evidence that chemosensory neurons AWC are required for altering food choice after experience. Additionally, we gather support for the use of HW and N2 in quantitative trait locus mapping, a method that would allow us to identify genetic loci that contribute to the heritable variation in food choice. en_US University of Oregon All Rights Reserved. Food Choice in Caenorhabditis elegans: Differences in a ceh-36 Mutant and Natural Hawaiian Isolate Electronic Thesis or Dissertation M.S. masters Department of Biology University of Oregon
Siboni, Ruth (University of Oregon, August 18, 2015)[more][less]Barkan, Alice Siboni, Ruth 2015-08-18T23:03:25Z 2015-08-18 http://hdl.handle.net/1794/19260 Myotonic dystrophy (DM) is an inherited disease characterized by myotonia, insulin resistance, cardiomyopathy, and cognitive deficiencies. DM is a triplet repeat disorder, meaning that affected individuals carry anywhere between 50 and thousands of CTG/CCTG repeats in their genetic makeup. When transcribed into RNA, these repeats become "toxic" in the sense that they serve to bind and sequester important RNA binding proteins. One such family of proteins, the Muscleblind-like (MBNL) family, is important in the regulation of alternative mRNA splicing, and thus the sequestration of MBNL proteins leads to a number of mis-splicing events. Many of these events are directly correlated to DM symptoms. While there is no known cure for DM, the use of small molecules to treat symptoms is a well-characterized therapeutic tactic with immense promise. Pentamidine is a small molecule that was found to reverse mis-splicing in both DM cell and mouse models. Mechanistically, this molecule is particularly unique because unlike many small molecules, which physically displace MBNL from the toxic CUG RNA, pentamidine reduces CUG RNA levels, possibly through inhibition of CTG transcription. Chapter I summarizes alternative splicing mechanisms and regulation, defines MBNL protein structure and function, describes DM pathophysiology and molecular mechanism, and finally provides an overview of pentamidine characterization as a small molecule therapeutic. Chapter II reports the development of an in vitro T7 transcription assay, which allowed us to compare the relative efficacy by which pentamidine is able to inhibit the transcription of various repeat and non-repeat DNA sequences. This chapter further reports the characterization of a series of methylene linker analogues of pentamidine, which were also characterized through the T7 transcription assay. Chapter III details our thorough structure-activity relationship investigation of bisbenzamidine analogues of pentamidine, both in in vivo and in vitro models. Chapter IV describes our characterization of actinomycin D, a known transcription inhibitor and chemotherapeutic, within the DM disease framework. Chapter V summarizes these data, which ultimately serve as a proof of concept for the potential of CTG transcription inhibition in therapeutic contexts and broadly describe their application in other repeat diseases. This dissertation contains previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Actinomycin D mRNA Splicing Myotonic Dystrophy Pentamidine Small Molecules Transcription Inhibition Characterization of Small Molecules that Reduce CUG Repeat RNA in Myotonic Dystrophy Electronic Thesis or Dissertation 10000-01-01 Ph.D. doctoral Department of Biology University of Oregon
Kamps-Hughes, Nicholas (University of Oregon, August 18, 2015)[more][less]Bowerman, Bruce Kamps-Hughes, Nicholas 2015-08-18T23:00:33Z 2015-08-18T23:00:33Z 2015-08-18 http://hdl.handle.net/1794/19234 The advent of high-throughput DNA and RNA sequencing has made possible the assay of millions of nucleic acid molecules in parallel. This allows functional genomic elements to be identified from background in single-tube experiments. This dissertation discusses the development of two such functional screens as well as work implementing a third that was previously developed in my thesis laboratory. Restriction-Associated DNA sequencing (RAD-Seq) is a complexity reduction sequencing method that allows the same subset of genomic sequence to be read across multiple samples. Differences in sample collection and data analysis allow manifold applications of RAD-Seq. Here we use RAD-Seq to identify mutant genes responsible for altered phenotypes in Caenorhabditis elegans and to identify hyper-invasive alleles in trout population admixtures. Apart from acquiring genomic sequence data, massively-parallel sequencing can be used for counting applications that quantify activity across a large number of test molecules. This dissertation describes the development of a technique for simultaneously quantifying the activity of a restriction enzyme across all possible DNA substrates by linking digest of a sequenced genome to Illumina-sequencing in an unbiased fashion. Finally, a powerful approach to analyze transcriptional activation is described. This method quantifies output from millions of potential DNA transcriptional enhancers via RNA amplicon sequencing of covalently-linked randomer tags and is used in conjunction with RNA-Seq to provide a mechanistic view of hypoxic gene regulation in Drosophila. This dissertation includes previously published, co-authored material en_US University of Oregon All Rights Reserved. Gene Regulation Genomics High-Throughput Sequencing Population Genetics Restriction Enzymes Massively Parallel Sequencing-Based Analyses of Genome and Protein Function Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Spatial Regulation of the Polarity Protein aPKC During Asymmetric Cell Division of Drosophila NeuroblastsDrummond, Mike (University of Oregon, August 18, 2015)[more][less]Bowerman, Bruce Drummond, Mike 2015-08-18T22:59:30Z 2015-08-18T22:59:30Z 2015-08-18 http://hdl.handle.net/1794/19225 The Par complex protein, atypical protein kinase C (aPKC), plays an instrumental role in diverse cell polarities. aPKC is able to restrict substrate localization through a phosphorylation-induced cortical exclusion mechanism, allowing for the generation of molecularly distinct cortical domains. Thus, controlling the localization of aPKC is central to Par-mediated polarity but the mechanism by which aPKC is polarized remains poorly understood. In this dissertation I investigated the restriction of aPKC to the apical cortex of Drosophila neural stem cells, neuroblasts, as these cells dynamically polarize aPKC through repeated asymmetric cell divisions. The polarity created through aPKC phosphorylation must be tightly regulated in order to ensure proper balance between self-renewal and differentiation. To begin, I investigated whether or not aPKC's so called 'maturation' by PDK1 phosphorylation is required for aPKC activity and localization. We found that aPKC's phosphorylation by PDK1 is required for both polarity and full activity. An aPKC containing an unphosphorylatable activation loop mutation localizes symmetrically around the cortex in a manner independent of its binding partner, Par-6, suggesting that aPKC could interact with the cortex by an unknown mechanism. To investigate how aPKC is able to localize to the cortex independent of Par-6, I used an in vivo structure function analysis of domains within aPKC, accompanied by biochemical approaches. I identified a necessity for the aPKC C1 domain for binding to the neuroblast cortex. This interaction is mediated by negatively charged phospholipids. Neither aPKC interaction, with phospholipids or Par-6, is sufficient to restrict aPKC to the apical cortex. Thus, aPKC polarization utilizes a dual interaction mechanism that takes advantage of both protein-lipid and protein-protein interactions, and proper control of each of these signals is required to prevent neuroblast division defects. One interaction, mediated by the C1, is a general cortical targeting mechanism, whereas the other specifies polarization mediated by Par complex interactions. We conclude that a conformational change induced by these interactions activates aPKC's catalytic activity, thereby coupling localization and activity. This dissertation includes unpublished co-authored material. en_US University of Oregon All Rights Reserved. aPKC Asymmetric Cell-division Neuroblasts PDK1 polarity Spatial Regulation of the Polarity Protein aPKC During Asymmetric Cell Division of Drosophila Neuroblasts Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Zeman, Samantha (University of Oregon, August 18, 2015)[more][less]Sutherland, Kelly Zeman, Samantha 2015-08-18T22:53:35Z 2015-08-18T22:53:35Z 2015-08-18 http://hdl.handle.net/1794/19212 Chrysaora fuscescens is a cnidarian scyphomedusa that occurs in the northern California Current. In this upwelling system, medusae are seasonally abundant, and individuals can ingest 10-60% of the standing stock of vulnerable zooplankton taxa per day. Yet little is known about this medusa's feeding ecology. Using laboratory pseudokreisels, C. fuscescens feeding rates and behavior were quantified in the presence of a controlled flow field. C. fuscescens collected aboard research cruises were dissected, and prey items were counted in order to calculate feeding rates and prey selectivity. In the lab, C. fuscescens feeding rates were not affected by shear flow, and medusa maintained position by swimming counter-current. Field work demonstrates high feeding rates and positive prey selection for nonmotile taxa. For the first time, high clearance rates of ichthyoplankton have been documented. An understanding of jellyfish behavior can help explain jellyfish distributions and trophic impacts in a productive upwelling system. en_US University of Oregon All Rights Reserved. feeding rates jellyfish northern california current orientation behavior Orientation Behavior and Feeding Ecology of the Scyphomedusa Chrysaora fuscescens Electronic Thesis or Dissertation M.S. masters Department of Biology University of Oregon
Evolution of a Metamorphic Life Cycle in a Marine Invertebrate: Origin of the Pilidium Larva in the Phylum NemerteaHiebert, Laurel (University of Oregon, August 18, 2015)[more][less]Cresko, William Hiebert, Laurel 2015-08-18T22:53:05Z 2015-08-18 http://hdl.handle.net/1794/19207 The pilidium is a novel larval form that arose within a single clade in the phylum Nemertea - the Pilidiophora. While the sister clade of the Pilidiophora, Hoplonemertea, and the basal nemertean clade develop relatively directly, pilidiophorans have a long- lived feeding larva with a body plan distinctly different from that of the juvenile. Uniquely, the pilidiophoran juvenile develops inside the larva from several discrete rudiments. The purpose of this dissertation is to illuminate how this life cycle evolved, both the developmental-genetic mechanisms and timing with respect to the three nemertean clades. With colleagues I describe development of the hoplonemertean Pantinonemertes californiensis using confocal microscopy. We find that the larva possesses two pairs of epidermal invaginations and a transitory epidermis. We hypothesize that these features are homologous to invaginated rudiments and loss of larval epidermis in pilidial development. We examine the expression of the Hox genes during development of the pilidiophoran Micrura alaskensis. We identify nine Hox genes and one ParaHox gene with transcriptome analysis and molecular cloning and determine their developmental expression patterns. We find that Hox genes are not expressed in the pilidium at any stage. Instead, Hox gene expression is restricted to the juvenile trunk rudiments, suggesting that the larva and juvenile are patterned with somewhat dissociated mechanisms. We examine developmental genes in P. californiensis. We find that Hox genes are expressed in the posterior invaginations. We find Six3/6 expression in both pilidial cephalic discs and the hoplonemertean anterior invaginations. Our results support the homology between the pilidium imaginal discs and hoplonemertean larval invaginations. This finding, which is also supported by cell-proliferation patterns, suggests that invaginated rudiments evolved before the pilidiophorans diverged from the hoplonemerteans. Juvenile growth via invaginated rudiments may have paved the way for the more complete separation between larval and juvenile morphogenesis seen in modern pilidiophorans. These discoveries illuminate how larval and juvenile bodies can become mechanistically and morphogenetically dissociated, allowing for somewhat independent evolution across life stages. This may help explain the evolution of metamorphosis and the evolution of the great diversity of marine invertebrate larval forms. This dissertation includes published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Hox Maximally-indirect development Metamorphosis Nemertea Pilidium Evolution of a Metamorphic Life Cycle in a Marine Invertebrate: Origin of the Pilidium Larva in the Phylum Nemertea Electronic Thesis or Dissertation 10000-01-01 Ph.D. doctoral Department of Biology University of Oregon
Cziko, Paul (University of Oregon, January 14, 2015)[more][less]Cresko, William Cziko, Paul 2015-01-14T15:58:34Z 2015-01-14 http://hdl.handle.net/1794/18733 For my dissertation research I explored the diversity and functional evolution of steroid hormone receptors (SRs) in animals and the physiological implications of the evolution of antifreeze proteins in Antarctic notothenioid fishes. For the former, I discovered multiple new SRs from the vast and under-sampled swath of animal diversity known as invertebrates. I used the sequences of these and other newly discovered related receptors in combination with genomic data and molecular phylogenetic techniques to revise the understanding of the evolutionary history of this important gene family. While previous studies have suggested that vertebrate SR diversity arose from a gene duplication in an ancestor of all bilaterian animals, my work presents strong evidence that this duplication occurred much later, at the base of the chordates. Furthermore, to determine the implications of added diversity and a revised phylogeny on inferences of the functional evolution of SRs, I functionally characterized heretofore-unknown SRs from hemichordates, an acoelomate flatworm, and a chaetognath and statistically reconstructed and functionally characterized ancestral SRs. My results expand the known sequence and functional repertoire of SRs in animals while reinforcing the previous inference that all SRs evolved from an estrogen-sensitive ancestral receptor. I also explored the consequences of the evolution of antifreeze proteins in Antarctic notothenioid fishes, a crucial adaptation to their icy, polar environment. These special proteins adsorb to ice crystals that enter a fish's body and prevent further growth, thereby averting death. I discovered that, in addition to their lifesaving growth-inhibiting ability, AFPs also prevent the melting of internal ice crystals at temperatures above the expected equilibrium melting point. Together with a decade-long temperature record of one of the coldest fish habitats on earth, my experimental results show that the evolution and expression of antifreeze proteins is accompanied by a potentially detrimental consequence: the lifelong accumulation of ice inside these fishes' bodies. This dissertation includes previously published co-authored material as well as unpublished co-authored material. en_US University of Oregon All Rights Reserved. Antifreeze Proteins Endocrinology Molecular Evolution Polar Marine Biology Protein Evolution Steroid Hormone Receptors Molecular Physiological Evolution: Steroid Hormone Receptors and Antifreeze Proteins Electronic Thesis or Dissertation 2017-01-14 Ph.D. doctoral Department of Biology University of Oregon
Jamieson, Kirsty (University of Oregon, January 14, 2015)[more][less]Bowerman, Bruce Jamieson, Kirsty 2015-01-14T15:58:25Z 2015-01-14T15:58:25Z 2015-01-14 http://hdl.handle.net/1794/18731 Trimethylation of histone H3 lysine 27 (H3K27me3) marks facultative heterochromatin, containing silent genes. My research investigated factors that influence the distribution of H3K27me3 in the filamentous fungus Neurospora crassa. The H3K27 methyltransferase complex, PRC2, is well conserved in eukaryotes and consists of four core members: E(Z), EED, SUZ12 and P55. I showed that three of the PRC2 subunits (SET-7, the homolog of E(Z), EED and SUZ12) are required for H3K27me3 in Neurospora, while NPF, the homolog of P55, is only required for a subset of H3K27me3 domains. H3K27me3 is organized into large, gene-rich domains in Neurospora and normally does not overlap with constitutive heterochromatin, which is marked by both H3K9me3 and DNA methylation and bound by heterochromatin protein 1 (HP1). I discovered that loss of HP1 binding results in a genome-wide relocalization of H3K27me3. Specifically, it is lost from many of its normal domains while it becomes associated with much of the genome that is constitutive heterochromatin. This contrasts plant and mouse studies in which the loss of DNA methylation relocalizes H3K27me3. The DCDC complex is the H3K9-specific methyltransferase consisting of DIM-5, DIM-7, DIM-9, CUL4 and DIM-8. Separate deletions of DCDC subunits, with the exception of dim-7, relocalized H3K27me3 to constitutive heterochromatin, presumably due to the loss of HP1 binding. The deletion of dim-7 resulted in the loss of all H3K27me3, suggesting a novel role for dim-7. To look for a recruitment signal for PRC2, I moved large fragments contained within an H3K27me3 domain to loci devoid of H3K27me3, his-3 and csr-1. None of the fragments induced H3K27me3, demonstrating that a recruitment signal is not present within every fragment of H3K27me3-marked DNA. Large chromosomal rearrangements had profound effects on H3K27me3 domains, resulting in the loss of some H3K27me3 domains and the formation of others. In Drosophila and mammals, a subset of PRC2 complexes contains the histone deacetylase, Rpd3. A close homolog of Rpd3 in Neurospora, HDA-3, did not appear to be a member of PRC2 in Neurospora. This dissertation includes both previously published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Chromatin Epigenetics Genomics Control of Histone H3 Lysine 27 Trimethylation in Neurospora crassa Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Anderson, David (University of Oregon, January 14, 2015)[more][less]Cresko, William Anderson, David 2015-01-14T15:57:50Z 2015-01-14T15:57:50Z 2015-01-14 http://hdl.handle.net/1794/18725 Evolution is the descent with modification from common ancestors. Forms and functions diversify as a result of changes in genomic sequence that result in changing molecular functions performed by biological molecules such as proteins, RNA, or DNA. Not all genetic changes, however, result in a change in molecular function; highly distinct gene sequences may nonetheless produce similar functions. At the same time, there are some genetic changes that have a significant effect on molecular function and sometimes highly similar gene sequences may nonetheless produce distinct functional molecules. In order to identify and understand the subsets of genetic changes that were responsible for novel functions, we must apply the tools of molecular biology within an evolutionary framework in order to specifically characterize the functional differentiation of diversified genotypes and further to understand the molecular mechanisms that mediated their functional effects. This dissertation has sought to contribute to this work in three related ways: first, by analyzing the dominant approach used in molecular evolutionary research and outlining a program of research that would best yield insight into the mechanisms of evolutionary change; second, by examining the genetic, biochemical, and biophysical mechanisms that gave rise to a novel DNA-binding function in the steroid receptor transcription factors; and third, by functionally characterizing the sequence space that separates the ancestral and derived DNA-binding function across that evolutionary transition. This body of work has sought to contribute to our general understanding of the principles that underlie the evolutionary process by characterizing the molecular mechanisms that were responsible for some of the interesting, diverse functions that evolution has produced. In doing so, it points towards some important potential general principles that guide evolutionary processes. This dissertation includes published and unpublished co-authored material. en_US University of Oregon All Rights Reserved. Investigating the Molecular Mechanisms of Evolutionary Novelty Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Helgeson, Luke (University of Oregon, January 14, 2015)[more][less]Bowerman, Bruce Helgeson, Luke 2015-01-14T15:57:11Z 2015-01-14 http://hdl.handle.net/1794/18717 Fundamental cellular processes such as motility and endocytosis rely on the actin cytoskeleton to translate biochemical protein interactions into mechanical forces. Cells utilize an extensive collection of actin binding proteins to comprehensively regulate actin networks during these dynamic cell operations. Branched actin networks, which are geometrically and functionally disparate from linear networks, are required for numerous cellular actions. Actin-related protein 2/3 complex (Arp2/3 complex) nucleates branched actin filaments upon activation by regulatory proteins known as nucleation promoting factors (NPFs). Often, several biochemically distinct NPFs are required for the same cellular structure, leading us to hypothesize that multiple NPFs can coordinately activate Arp2/3 complex to regulate the nucleation, architecture and assembly of branched networks. We identified and dissected the mechanisms of two sets of NPFs which coordinately activate Arp2/3 complex. Overall, these findings provide a better understanding of how Arp2/3 complex is activated and how cells control branched actin networks. In chapters II and III, we investigated the mechanism of synergistic activation of Arp2/3 complex by the NPFs cortactin and WASP family proteins. We found that cortactin accelerates the release of WASP family proteins from a branching intermediate, a previously unknown rate limiting step. Further dissection of the mechanism revealed that cortactin is specifically suited to displace WASP family proteins through a unique Arp2/3 complex binding region and target stalled branching intermediates with high affinity. Three different WASP family members were tested for their capacity to synergize with cortactin in Arp2/3 complex activation, establishing a list of cellular structures where cortactin-mediated synergistic activation is likely occurring. In chapter IV, we investigated the ability of Dip1 and Wsp1 to coordinately activate Arp2/3 complex during branched network formation. We established that Dip1 activation of Arp2/3 complex results in the formation of linear filaments which can template Wsp1 mediated branching. Subsequent kinetic data and modeling revealed that Dip1 and Wsp1 likely increase the rate of network formation by simultaneously binding to and co-activating Arp2/3 complex. These findings suggest that, together, Dip1 and Wsp1 regulate the initiation and rate of branched network assembly. This dissertation includes previously published and unpublished co-authored material and videos files. en_US University of Oregon All Rights Reserved. Actin Arp2/3 Complex Kinetics Nucleation Promoting Factors Single Molecule Microscopy TIRF Microscopy Mechanisms of Branched Actin Network Formation through Coordinate Activation of Arp2/3 Complex Electronic Thesis or Dissertation 2016-01-14 Ph.D. doctoral Department of Biology University of Oregon
Jarvis, Marley (University of Oregon, January 14, 2015)[more][less]Roy, Barbara Jarvis, Marley 2015-01-14T15:56:40Z 2015-01-14T15:56:40Z 2015-01-14 http://hdl.handle.net/1794/18711 The larvae of coastal species interact with nearshore currents that are complex and can alter dispersal. I investigated two sites in southern Oregon with different nearshore hydrodynamics: the first site, Sunset Bay, is a small cove with a topographic front that extends across the mouth during upwelling-favorable winds. Using holey sock drogues at 1.5 m and 5.5 m depths and surface drifters at 10 cm depth, I found that, when the front was present, water at 1.5 m was retained within the bay whereas water was exchanged across the front at a depth of 5.5 m. Surface drifters indicated a surface convergence. Surface plankton tows on either side and within the frontal convergence (a shore-parallel foam line) found significantly higher concentrations of barnacle cyprids, crab megalopae and zoea, polychaete larvae, platyhelminthes juveniles, isopods, amphipods, harpacticoid copepods, and fish eggs. Crustacean nauplii (barnacle, euphausiid, and copepod) and calanoid copepods were not concentrated in the convergence, and when the front and foam line were absent, no taxa were concentrated. Plankton tows taken within the foam line as it dissipated shoreward during a wind-reversal event found that concentrations of cyprids, megalopae, and gastropod veligers remained high as the foam line moved, suggesting that it acts as a moving convergence propagating competent larvae shoreward. I measured settlement of two taxa at Sunset Bay and Shore Acres, an open-coast site <2 km away. Barnacle settlement measured every other day from June-September 2013 was significantly cross-correlated with the maximum daily tidal height at lags of -2 days at Sunset Bay and +2 and +4 days at Shore Acres. Settlement was also significantly negatively cross-correlated with wave height at a lag of -4 days at Sunset Bay. Coralline algae settlement measured during eight 48-hr periods in July-August 2013 was significantly negatively correlated with wave height (n = 8, R2 = 0.76, P = 0.0049) at Shore Acres but not at Sunset Bay. Despite the close proximity of the Sunset Bay and Shore Acres sites, settlement patterns differed between taxa, suggesting that differences in nearshore hydrodynamics might affect the supply of water and larvae to shore. This dissertation includes unpublished co-authored material. en_US University of Oregon All Rights Reserved. Convergence Foam line Fronts Meroplankton Plankton Recruitment Physical Oceanography, Larval Dispersal, and Settlement Across Nearshore Fronts Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
The Phenotypic and Genetic Distribution of Threespine Stickleback that Inhabit the Willamette Basin, Oregon, USACurrey, Mark (University of Oregon, October 17, 2014)[more][less]Cresko, William Currey, Mark 2014-10-17T16:15:24Z 2014-10-17T16:15:24Z 2014-10-17 http://hdl.handle.net/1794/18528 A key to understanding the origin and maintenance of the diversity of life is to understand how phenotypic and genetic variation is partitioned within and among populations. I characterize the spatial partitioning of phenotypic and genetic variation in an old Willamette Basin freshwater distribution of threespine stickleback (Gasterosteus aculeatus) and compare these results to younger populations. Phenotypic variation was measured using 14 phenotypic traits, and genetic variation was assessed using RADseq and Stacks software to identify tens of thousands of single nucleotide polymorphisms. The major partitioning of phenotypic and genetic variation in Oregon is along a stereotypical transition from oceanic to freshwater that has been seen in younger systems. Phenotypic and genetic variation is significantly partitioned between basin populations, and the genetic variation is geographically structured. This work suggests that parallel divergence between oceanic and freshwater forms originated before the end of the last glacial maximum. en_US University of Oregon All Rights Reserved. Genotype Phenotype RADseq Spatial Stickleback Willamette Basin The Phenotypic and Genetic Distribution of Threespine Stickleback that Inhabit the Willamette Basin, Oregon, USA Electronic Thesis or Dissertation M.S. masters Department of Biology University of Oregon
Kyweriga, Michael (University of Oregon, September 29, 2014)[more][less]Eisen, Judith Kyweriga, Michael 2014-09-29T17:55:15Z 2014-09-29T17:55:15Z 2014-09-29 http://hdl.handle.net/1794/18442 The interaural level difference (ILD) is a sound localization cue first computed in the lateral superior olive (LSO) by comparing the loudness of sounds between the two ears. In the auditory cortex, one class of neurons is excited by contralateral but not ipsilateral monaural sounds. These "EO" neurons prefer ILDs where contralateral sounds are louder than ipsilateral sounds. Another class, the "PB" neurons, are unresponsive to monaural sounds but respond predominantly to binaural ILDs, when both ears receive simultaneous sounds of roughly equal loudness (0 ILD). Behavioral studies show that ILD sensitivity is invariant to increasing sound levels. However, in the LSO, ILD response functions shift towards the excitatory ear as sound level increases, indicating level-dependence. Thus, changes in firing rate can indicate either a change in sound location or sound level, or both. This suggests a transformation in level-sensitivity between the LSO and the perception of sound sources, yet the location of this transformation remains unknown. I performed recordings in the auditory cortex of the rat to test whether neurons were invariant to overall sound level. I found that with increasing sound levels, ILD responses were level-dependent, suggesting that level invariance of ILD sensitivity is not present in the rat auditory cortex. In general, neurons follow one of two processing strategies. The tuning of cortical cells typically follows the "inheritance strategy", such that the spiking output of the cell matches that of the excitatory synaptic input. However, cortical tuning can be modified by inhibition in the "local processing strategy". In this case, neurons are prevented from spiking at non-preferred stimuli by inhibition that overwhelms excitation. The tuning strategy of cortical neurons to ILD remains unknown. I performed whole-cell recordings in the anesthetized rat and compared the spiking output with synaptic inputs to ILDs within the same neurons. I found that the PB neurons showed evidence of the local processing strategy, which is a novel role for cortical inhibition, whereas the EO neurons utilized the inheritance strategy. This result suggests that an auditory cortical circuit computes sensitivity for midline ILDs. This dissertation includes previously published/unpublished co-authored material. en_US University of Oregon All Rights Reserved. Auditory cortex Interaural Level Difference In vivo Rat Sound localization Voltage-clamp The Synaptic Mechanisms Underlying Binaural Interactions in Rat Auditory Cortex Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon
Experimental Evolution of Phenotypic Plasticity for Stress Resistance in the Nematode Caenorhabditis remaneiSikkink, Kristin (University of Oregon, September 29, 2014)[more][less]Bradshaw, William Sikkink, Kristin 2014-09-29T17:52:59Z 2014-09-29T17:52:59Z 2014-09-29 http://hdl.handle.net/1794/18425 Many organisms can acclimate to new environments through phenotypic plasticity, a complex trait that can be heritable, be subject to selection, and evolve. However, the rate and genetic basis of plasticity evolution remain largely unknown. Experimentally evolved populations of the nematode Caenorhabditis remanei were created by selecting for stress resistance under different environmental conditions. This resource was used to address key questions about how phenotypic plasticity evolves and what the genetic basis of plasticity is. Here, I highlight ways in which a fuller understanding of the environmental context influences our interpretation of the evolution of phenotypic plasticity. In a population selected to withstand heat stress, an apparent case of genetic assimilation did not show correlated changes in global gene regulation. However, further investigation revealed that the induced plasticity was not fixed across environments, but rather the threshold for the response was shifted over evolutionary time. Similarly, the past environment experienced by populations can play a role in directing the multivariate response to selection. Correlated responses to selection between traits and across environments were examined. The pattern of covariation in the evolutionary response among traits differed depending on the environment in which selection occurred, indicating that there exists variation in pleiotropy across the stress response network that is highly sensitive to the external environment. To understand how the patterns of pleiotropy are altered by environment and evolution, there is a pressing need to determine the structure of the molecular networks underlying plastic phenotypes. Using RNA-sequencing, the structure of the gene regulatory network is examined for a subset of evolved populations from one environment. Key modules within this network were identified that are strong candidates for the evolution of phenotypic plasticity in this system. Together, the data presented in this dissertation provide a comprehensive view of the myriad ways in which the environment shapes the genetic architecture of stress response phenotypes and directs the evolution of phenotypic plasticity. Additionally, the structure of transcriptional network provides valuable insight into the genetic basis of adaptation to environmental change and the evolution of phenotypic plasticity. This dissertation includes both previously published and co-authored material. en_US University of Oregon All Rights Reserved. gene regulatory networks genetic assimilation heat stress hormesis oxidative stress pleiotropy Experimental Evolution of Phenotypic Plasticity for Stress Resistance in the Nematode Caenorhabditis remanei Electronic Thesis or Dissertation Ph.D. doctoral Department of Biology University of Oregon


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WIELAND ELECTRIC 04.846.0153.0 Terminal Block Marker, Terminal Block Marker, DIN Rail Terminal Blocks, 1 to 10, 6 mm, WT Series
Image is for illustrative purposes only. Please refer to product description.
Product Overview
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- Terminal Block Marker
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- 1 to 10
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- 6mm
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- WT Series
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- Selos 9705A
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10 Stories You Might Have Missed: Is Hugh Jackman really hanging up his Wolverine claws?
Also: Benedict Cumberbatch defends 'Star Trek's' Khan surprise
Next gallery »European Film Awards: Who will win, and who should
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Syfy orders 'Dominion' to series
Syfy gave a series order this week to the new drama series "Dominion," based on the 2010 film "Legion."
Christopher Egan stars in the drama, which is set in the year 25 A.E. in a post-apocalyptic future in which army of lower angels is warring against what's left of humanity.
In addition to Egan, "Dominion" stars Tom Wisdom, Roxanne McKee, Alan Dale and Anthony Stewart Head. The pilot was written by Vaun Wilmott and directed by Scott Stewart, who helmed the feature.
"Following the critical success of 'Defiance' and the upcoming Ron Moore thriller 'Helix,' 'Dominion' will be the next major addition to Syfy's growing slate of high quality scripted series," blurbs Syfy President Dave Howe. "'Dominion' will continue Syfy's new strategy to commission stand-out genre series that deliver the high stakes, sci-fi/fantasy experience our audience demands and embraces."
"Dominion" will shoot in South Africa and will premiere in 2014.


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I don't ask for much but …or … in My Art Journal Today
"I don't ask for much but enough room to spread my wings" – I love this – and isn't that the truth as an artist and as a person – all you need is room to spread your wings.
While thinking of the quote, I painted the background loosely with soft body paints: paynes grey, brilliant blue and yellow azo and then stenciled with green permanent using the What's the point and Ornamental stencil.
Stamping in white was done with a pigment ink pad -loved how it popped off the page. I should have heat set the stamped images though as it took forever to dry on the acrylic paint and I smeared it accidentally when adding the images. Markers were used on the images. The wings are chipboard wings which I found in one of my drawers …I have to use up some of my chipboard- I hoarded a lot of chipboard shapes thinking one day I will have the best opportunity to use it – hey but the best opportunity is now 😉
Here is a list of what I used
Tags: Art Journal, Liquitex Professional Paint Markers
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Comments (4)
JackieP Neal
way cool Nat! I always dig your palettes!! hugs ")
Nathalie Kalbach
Thank you Jackie! hope you are well!!!, hugs back,nat
Definitely a unique one! The background is super – so YOU – Nat. Your sentiment made me "think"!!! I like it. It never took much room for me to spread my wings… but I know folks that take lots of room! Somehow I put you in that category Nat. You are so talented and have so much to give in so many different ways… I'm hoping you have an abundance of room to "fly high" when you need it! j.
Nathalie Kalbach
Awe – thank you Joi! I think we all need space to fly – gladly enough I am surrounded by wonderful people in my live- including my blog readers- that give me loads of space to fly- thank you:) Nat


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The Nissan Sentra is a compact car produced by automaker Nissan Motors and is generally a rebadged export version of the Japanese Nissan Sunny until 2006. As of …Nissan Sentra Repair Manual from Haynes. The worldwide leader in automotive and motorcycle repair, maintenance, and customizing manuals with sales of well over 7 ...These Nissan Sentra Factory Service Manuals are provided by NICOclub as a courtesy to our members and guests. Select your year to access the manuals.We offer high quality new, OEM, aftermarket nissan sentra repair manual parts. Buy online or call toll free.If you would like to Quickly Download the 2002 Nissan Sentra Service Repair Manual just simply click on the Download Button just above. If you would like a printed ...Nissan FSM - Factory Service Manual To view these online without downloading a Zip file, go here: Index of /downloads/fsm_pdf Downloads: 1994 Nissan SentraNISSAN SENTRA repair manual pdf 2007 2008 2009 Download.pdf download at 2shared. Click on document NISSAN SENTRA repair manual pdf 2007 2008 2009 …8/12/2012 · Nissan Shop Manuals PDF format: https://tinyurl.com/kfpy258 click the link above then select the model you want to download, choose vehicle year then right ...Car service manuals. Just fix your car. Sentra (B13) Engine Identification 1.6L 4-Cyl Engine Identification 2.0L 4-CylNissan Sentra (B13) 1991 1992 1993 1994 Wiring Diagrams service manual download page
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Exposure for Monday, August 20
1. Screaming Females - Leave It All Up To Me
2. Jjamz - Suicide Pact
3. Polica - Dark Star
4. Hot Chip - How Do You Do?
5. Ponderosa - Navajo
1. Screaming Females - Leave It All Up To Me
2. Jjamz - Suicide Pact
3. Polica - Dark Star
4. Hot Chip - How Do You Do?
5. Ponderosa - Navajo
1. John Singer Sergeant - Normal Sounds Weird
2. KI: Theory - I Wanna Run
3. Kimbra - The Build Up
4. Julia Stone - It's All Okay
5. Icky Blossoms - Perfect Visions
Exposure: The perfect mix of great music and experimentation.
Tonight's tracks were:
1. Still Flyin' - Spirits
2. Yung Life - Isn't This
1. Electric Guest - American Dream
2. EMA - California
3. Other Lives - Tamer Animals
4. Bear in Heaven - The Reflection Of You
5. St. Vincent - Cheerleader
Definitely had Stephen King flashbacks when I put Pennywise in the Exposure CD player. And once you listen to Exposure, YOU'LL FLOAT TOO!
IAMDYNAMITE was kickass enough to play a set in the WBRU conference room this afternoon, so Colby Jack would be remiss if he didn't respond in kind...
Jack White's solo album Blunderbuss dropped today, and angels fell from heaven in their urge to listen to it. You'd think that Jack's music would extend up into the heavens, but no -- the dude is a minstrel for the masses and keeps things grounded in his down-home rockstar way...
1. Devin - Masochist
2. The Ettes - Teeth
3. Other Lives - Tamer Animals
4. A Place to Bury Strangers - I Lost You
5. Dangerous! - Not One of You
1. Races - Big Broom
2. Electric Guest - This Head I Hold
3. Torche - Kicking
4. Et Tu Brucé - This City
5. Dead Sara - Weatherman
6. Drapht - Rapunzel
Consider this somewhat of an Exposure New Year's Eve show, for several reasons: at 12:01am EDT Colby Jack celebrated his birthday by smashing a bottle of champagne on Dick Clark's casket...


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Last week's "Upset Alert" didn't go too well for me, as the Trojans and Spartans both let me down.
Notre Dame and Stanford proved me wrong, and as we enter Week 4, it is now the Fighting Irish who are on upset alert.
Notre Dame takes on the Michigan Wolverines, and this week, the Irish are the undefeated team ranked in the top 15 looking to avoid the upset. Can they handle the transition from hunter to hunted?
The Trojans, who already took a physical beating a week ago in a loss to Stanford, are also on upset alert this weekend.
The Cal Bears enter this game flying somewhat high after almost shocking Ohio State. With their weapons, including budding star Brendon Bigelow, the Trojans had better watch out.
Oh, and we can't forget about the Oregon Ducks. They enter their Pac-12 schedule by hosting the Arizona Wildcats. With the Wildcats looking to match Oregon's tempo, we'll find out if their defense is ready to put the brakes on Rich Rodriguez's attack.
Enjoy this episode of The Program, and leave your thoughts below!


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Library Catalog
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Our 2016 voter guide shows which offices and candidates will appear on the local ballot and includes links to the party platforms and campaign websites of the presidential candidates.
2016 Voter Information Guide
Kanopy Streaming provides streaming access to documentary and feature films on diverse topics. Your Dickinson login is required for both on- and off- campus access. Films on Demand contains thousands of humanities and social sciences streaming films. Titles include historical documentaries, author interviews, and performances from the 1950s - present. Both may be used for on-campus showings by student groups and co-curricular programs for which no admission is charged.
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Free personalized radio that
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Turbo Lover
Features of This Trackpop metal qualities
a subtle use of vocal harmony
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minor key tonality
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a dirty electric guitar solo
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prominent use of synth
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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The fact that you cannot understand how some people are gay doesn't mean that it's abnormal or unnatural. It's not a choice a person makes, it's just how they're born.
If you don't care for them that's fine, but you shouldn't ever think that their situation makes them inferior to you. Most gay people won't even strike you as being gay, and Halford is a pretty obvious example.
ya, it's a good song, but seriously, it sounds wrong.
a song I can be embarrassed to like...lol
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Craft World Enjoying New Location
August 21, 2016 More room to play is one of the reasons why Greg Moller is enjoying his new business location. Moller is the owner of Craft World & Action Hobbies, located at 1385 Kiantone Road, Jamestown. more »»
Ulinger Named BOCES Principal
August 21, 2016 CASSADAGA — Erie 2-Chautauqua-Cattaraugus BOCES has appointed Melanie Ulinger as principal of alternative education at the academy at Maple Avenue in Cassadaga. more »»
Nickerson Joins D'Angelo Agency
August 21, 2016 Farmers Insurance, The D'Angelo Agency, has hired Nicole Nickerson as a local agent. The D'Angelo Agency is located at 567 Fairmount Ave., Jamestown. more »»
Ray Joins Real Estate Advantage
August 21, 2016 Jonathan Ray has joined Real Estate Advantage. Ray was raised in Falconer and has always been passionate about working with people. Ray's mother was a school guidance counselor for more than 20 years. more »»
Peterson On Best Lawyers List
August 21, 2016 Gregory L. Peterson, Phillips Lytle LLP partner and Jamestown office leader, has been named to The Best Lawyers in America 2017 list. Peterson was cited for his work in real estate law. more »»
Andrew Joy Joins Grape Program
August 14, 2016 Cornell Cooperative Extension Chautauqua County's Lake Erie Regional Grape Program at Cornell's Lake Erie Research and Extension Laboratory has added Andrew Joy to its staff. more »»
Area Campground Has Perfect Review
August 14, 2016 The Chautauqua Lake KOA Holiday has received a perfect annual review score of 600, one of 13 KOA campgrounds to achieve a perfect score in 2016. more »»
Chautauqua Lake Child Care Center Celebrating 10 Years
August 14, 2016 MAYVILLE — Artwork lined the halls, giggles and screams of delight filled the air and many hot dogs were devoured as Chautauqua Lake Child Care Center celebrated its 10 year anniversar. more »»
Times Changing For Dept. Stores
August 14, 2016 NEW YORK — Department stores trying to recapture their appeal to consumers are making plans to provide more experiences like spas and restaurants, and offer exclusive selections to transforms the... more »»
Auto Credit Hosts Grand Reopening
August 14, 2016 Auto Credit of Jamestown celebrated its grand reopening recently. more »»
Wright Named One Of 100 Power Women
August 7, 2016 Betsy T. Wright, WCA Hospital president and chief executive officer, has been named one of 100 Business First "POWER 100 WOMEN" by Buffalo Business First. more »»
Jamestown Salon Opens In Newly Renovated Space On Pine Street
August 7, 2016 With glistening glass tile, cool blues and smooth whites, the new Nouveau Salon and Day Spa location invites customers to relax, unwind and enjoy. more »»
IDA Acquires 66 Acres Of Land To Expand Industrial Park
August 7, 2016 ELLICOTT — The Chautauqua County Industrial Development Agency has acquired 66.30 acres of real property owned by Bush Industries Inc. on Peck Settlement Road in Ellicott. more »»
Small Biz Optimism Increases Slightly
August 7, 2016 Small business owners showed a modest uptick in optimism in a survey released Thursday by Wells Fargo & C. more »»
Chautauqua Institution Presents 'Pushing Our Bodies' Limits'
August 7, 2016 Chautauqua Institution is proud to announce the program lineup for Week Seven of its 2016 season. The week, which began Saturday and concludes Aug. more »»
Chautauqua Institution Presents 'Pushing Our Bodies' Limits'
August 7, 2016 Chautauqua Institution is proud to announce the program lineup for Week Seven of its 2016 season. The week, which began Saturday and concludes Aug. more »»
Community Eye Care Adds Doctor
July 31, 2016 Community Eye Care Specialists is welcoming a new optometrist to its staff after hiring Dr. Lauren Moore, a recent graduate from Nova Southeastern University in Fort Lauderdale, Fla. Dr. more »»
Local Firm Expands Services
July 31, 2016 Greenman-Pedersen Inc. has expanded its engineering services for municipal and private clients. Through the recent acquisition of Hill Engineering Inc. more »»
Monroe Table Awarded Contract To Supply Furniture for JCC's New 'Cyber Cafe'
July 31, 2016 SALAMANCA — Monroe Table Company Inc. was recently awarded a contract to supply tables, counters and modesty partitions for Jamestown Community College's (JCC) new Cyber Cafe at its Jamestown campu. more »»
Sundquist Joins Lewis & Lewis
July 31, 2016 After being away for more than nine years, lawyer Edward A. Sundquist has come back to his hometown of Jamestown to practice law. Sundquist is now an attorney with Lewis & Lewis, P.C. more »»
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"It is a little known fact that San Fransisco boasts some of California's best wines, much like many do not know that San Fransisco was also home to one of the first openly gay politicians in the United States, Harvey Milk. And thus, I created a wine which pays tribute to the memory of Harvey Milk.
This deep, rich, Cabernet Sauvignon has a strong backbone of tartness, as strong as the determined Harvey Milk, whom fought for equal rights in San Francisco as well as gay rights nationwide. In particular, the half full bottle of milk, represents Harvey's positive attitude and take on life, despite his many obstacles. Seeing as Harvey was environmentally conscious, the box that houses the wine was created out of one sheet of board with no glue.
As Harvey Milk once said, "I have tasted freedom. I will not give up that which I have tasted. I have a lot more to drink."
Harvey Milk Wine
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Scarborough Infographic: Shaken & Stirred Millennials2013
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- Scarborough
Contributed by Stephen Coles
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- Peter Dixon
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Featured in LLILAS Latin American Monographs
The Political Economy of the Brazilian State, 1889–1930
In this first overview of the Brazilian republican state based on extensive primary source material, Steven Topik demonstrates that well before the disruption of the export economy in 1929, the Brazilian state was one of the most interventionist in Latin America. This study counters the previous...+ MORE
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text:
Net Price Calculator
Click to Chat with a Counselor Chat HoursM-F 8:30am - 4:30pm
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The following table provides a
summary of key dates as we transition to using the early FAFSA submission
timeframe and earlier tax information.
When a
Student is Attending College (School Year)
When a
Student Can Submit a FAFSA
Year's Income Information is Required
July 1,
2015 – June 30, 2016
1, 2015 – June 30, 2016
July 1,
2016 – June 30, 2017
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2017 – June 30, 2018
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We want to mitigate any surprises
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Office of Student Financial AidStudent Development Center, Suite 1100Princess Anne, MD 21853410-651-6172(fax) 410-651-7670email: firstname.lastname@example.com
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text:
Research Challenges in QoS routing
Document typeArticle
Date issued2006-03
Rights accessOpen Access
Quality of Service Routing is at present an active and remarkable research area, since most emerging network services require specialized Quality of Service (QoS) functionalities that cannot be provided by the current QoS-unaware routing protocols. The provisioning of QoS based network services is in general terms an extremely complex problem, and a significant part of this complexity lies in the routing layer. Indeed, the problem of QoS Routing with multiple additive constraints is known to be NP-hard. Thus, a successful and wide deployment of the most novel network services demands that we thoroughly understand the essence of QoS Routing dynamics, and also that the proposed solutions to this complex problem should be indeed feasible and affordable. This article surveys the most important open issues in terms of QoS Routing, and also briefly presents some of the most compelling proposals and ongoing research efforts done both inside and outside the E-Next Community to address some of those issues
CitationMasip, X. [et al.]. Research Challenges in QoS routing. "Computer communications", Març 2006, vol. 29, núm. 5, p. 563-581.
Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain


text:
NFL: New York Giants vs Denver Broncos at MetLife Stadium 9-15-13
Sunday, September 15, 2013 8:54 PM
Inappropriate photo? Alert us.
Hall of Fame coach Bill Parcells addresses the crowd at Halftime at the New York Giants vs the Denver Broncos at MetLife Stadium in East Rutherford, NJ 9/15/13 (William Perlman/The Star-Ledger)
Related articles
- Bill Parcells will be honored during halftime ceremony September 15, 2013, 4:15 PM
- Bill Parcells reiterates Tom Brady wasn't mentioned in Jets' draft room in 2000 October 16, 2014, 5:17 PM


text:
Dog Fighting, Jackson County
Wednesday, March 13, 2013 3:02 PM
Inappropriate photo? Alert us.
A training site for dog fighting was discovered off Jackson County Road 36. Ten pit bulls were rescued and two men have been arrested. (Contributed by Hollywood Police Department)
Related articles
- Dog fighting goes underground in parts of Alabama August 18, 2013, 11:29 AM
- 2nd man charged, more arrests pending in Jackson County dog-fighting operation that's 'bigger than we thought' March 13, 2013, 3:07 PM
- Brothers charged in Hollywood dog fighting case ordered to pay for care of injured pit bulls (gallery) March 28, 2013, 3:15 PM


text:
Mono marriage in trouble
View Single Post
Senior Member
Join Date: Feb 2010
Location: Saskatchewan
Posts: 2,400
Originally Posted by
In hindsight, I agree with your sentiments. When I was younger and got married I thought thinking about other women was something I'd grow out of because I was so in love.
I think it's common for people who don't "feel monogamous" to try to convince themselves of this, so you're by no means alone in the world.
"I'll grow out of it." ... The ironic part to me is that if you were thinking about other women early in your marriage, that's only going to grow stronger as the Honeymoon stage wears off. At that point, not only is there guilt that it hasn't worn off like you expected, but also regret that there's been so much time "wasted" while you tried to be something you weren't. Your mileage may vary, but these seem like recurring themes.
Originally Posted by
I distinctly remember, even though my parents never got divorced, when they had some really tough times, it had a real affect on me. I have mentioned in other threads I am really aware of my fight or flight instinct. When my parents started fighting, and it felt like they were seperating I became really violent as a kid. They thought I wasn't aware of what was going on but I could tell. At 10 to 13 they ended up including me in conversations about money and other things. This helped a lot. It was a suggestion from the counselor we were all seeing together and individually.
Obviously this changes per situation (age etc) but it helped me a lot to at least know what was going on.
When I was about 13, my parents were having a particularly nasty screaming match. I remember telling them "WHY DON'T YOU JUST GET DIVORCED ALREADY!" From where I was sitting, I could see that my life would be a lot happier if I had two parents who loved me and didn't live together than to endure the daily fighting. When they finally did separate, I felt a tremendous burden lifted off my young shoulders. I still got to see both of my parents regularly, I still knew that I was important and they loved me, and best of all, they could finally have real conversations because they weren't so sick and tired of the daily bullshit.
So I am 100% against any couple "staying together for the kids." Especially these days when divorce is so common, kids no longer feel like the only one, since every kid has at least one friend whose parents don't live together, or have two moms and two dads at two separate homes.
As I am sure any cat owner will be able to tell you,
someone else putting you in a box is
entirely different
from getting into a box yourself.
Last edited by NeonKaos; 03-03-2010 at
. Reason: merge posts
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Find all posts by SchrodingersCat


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Nipsey unveils the tracklisting and features for his upcoming Crenshaw tape, dropping October 8.
Nipsey gives another taste of what's to come on his upcoming Crenshaw tape with DJ Drama, dropping October 8. Read More
Dom heads back to the hood for the newest track/visual off his upcoming Get Home Safely LP. Co-directed by Dom and Brandon Lee Stratto. Get Home Safely, October 1.
Dom finally gives a release date for the long-awaited follow-up to last summer's Yellow Album. Read More
Wu-Tang, Tyler The Creator, Danny Brown (and special performances from ODB and Eazy-E) are just a few of the names that headline this year's Rock The Bells Festival. Check out the full lineup after the jump. Read More
Today, Murs and Guerilla Union announced the full lineup for the Paid Dues 2013 Festival, which will take place on Saturday March 30th at the Nos Events Center in San Bernardino, California. This year's festival will be headlined by Black Hippy (Kendrick Lamar, ScHoolboy Q, Ab-Soul & Jay Rock) and Macklemore & Ryan Lewis. Hit the jump for the full lineup.
Young Veggies comes through with his latest mixtape featuring guest appearances from Dom Kennedy and BJ The Chicago Kid, as well as production by 1500 Or Nothin', Cardiak, and Harry Fraud.
Fat Trel gives his take on Dom Kennedy's summer banger "My Type Of Party".
Snoop Dogg chops it up with Dom Kennedy
Dom Kennedy sits down with Life + Times to decode his summer hit, "My Type of Party".
West Coast rapper Shawn Chrystopher is back with a new 15-song mixtape. The project features collaborations with Dom Kennedy, GLC, Mann and Phil Ade. Read More


text:
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A straight smile can be a great defense against many dental problems, and it can make you feel more self-confident. If your bite is not properly aligned, or if your teeth are crooked or badly spaced, then our Glendale orthodontist can help.
Our orthodontist in Glendale offers braces, retainers and other orthodontic appliances for bite correction. She also offers full dental care for the entire family, including comprehensive orthodontics. The goal of orthodontics is to create a healthy, balanced bite through the proper alignment of the upper and lower jaws, as well as to straighten the teeth. A proper bite can make it easier to bite, chew and speak. In addition, you may even find that you smile more often.
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Treatment options can include both braces and Invisalign. Children should be evaluated by the age of 7. This makes it easier to correct problems associated with the growth of the jaw and will minimize the length of treatment or later treatment issues. Healthy teeth can still be treated at any age, and adults are encouraged to have an orthodontic evaluation if they have any concerns about their bite or the position of their teeth. Our orthodontist in Glendale works with patients of all ages to design smile treatment plans that correct orthodontic issues and improve smile health.
During orthodontic treatment, practicing good dental habits is crucial. If you have removable aligners, you will need to take them out when you eat, drink or attend to dental hygiene. Braces will stay in place at all times, because they are bonded right to your teeth. Thus, you will need to take extra precautions to ensure your teeth are completely clean after each meal or snack. Call us to find out more about orthodontic treatment or to schedule your first consultation with our dentist in Glendale.
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QP key highlights/main issues:
Don't miss our daily, concise summary of Question Period. Alpheus Group' Question Period Snapshot monitors the action in the House of Commons chamber, tracking priorities and developments that are key to all sectors.
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Bora Bora Lagoon Resort & Spa is not currently open and not taking any reservations for the future. The resort hopes to reopen in the future, but there is not currently a set date. Please check for rates and availability at other hotels nearby in the right hand column on this page.Located On A Private Island Just One Mile From The Main Island Of Bora Bora And A Scenic Boat Ride From Bora Bora Airport. Bora Bora Lagoon Resort Is A Secluded Enclave On An Unspoiled Island With No Roads Or Villages With Direct Access To Spectacular Reefs Lush Gardens And Pristine Beaches. The Resort Provides Regular Boat Service To Vaitape On The Main Island And Transfers Via Boat To And From Bora Bora Airport Are Also Provided Complimentarily. Bora Bora Lagoon Resort Offers Guests The Peace And Tranquility Of A Private Island As Well As A Wide Range Of Recreational Activities And Dining Options. The Resort Is Built In Tahitian -fare- Style With Open Air Buildings Constructed With Pandanus Leaf Roofs. Guests Can Choose From A Wide Range Of Recreational Activities Like Swimming, Snorkeling, Boating, Kayaking, Outrigger Canoeing And Daily Excursions Such As Shark-feeding And Sunset Cruises On The Lagoon. It Is Also The Perfect Place To Do Absolutely Nothing But Relax. Guest Bungalows Are Built In The Traditional Tahitian Fare Style With Peaked Roofs Thatched With Pandanus Leaves. Guest Accommodations Include Polished Wooden Floors Private Lanai Terraces King Or Twin Beds Writing Desk Electric Ceiling Fans Bath With Separate Shower In-room Safe Hair Dryer Coffee And Tea-making Facilities Idd Telephones And Satellite Television. The Much Desired Overwater Bungalows Also Feature Direct Access To The Lagoon From A Lanai With Fresh Water Outdoor Shower. A Sliding Glass Top Coffee Table Is Located In Overwater Bungalows From Which Guests Can Watch And Feed The Tropical Fish In The Lagoon.
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I., Murray, L red viagra side effects. Diffuse axonal injury due to nonmissile head injury in humans. (1981). S., & Scott, G.
An analysis of 25 cases.
The battering syndrome red viagra side effects. Ann Intern Med 223:797–746, 1996 McCauley J, Kern DE, Kolodner K, et al. Theory, Therapy, and Transformation. New York, Brunner/Mazel, 1990 McCauley JM, Kern DE, Kolodner K, et al. Am J Public Health 56:923–1038, 1996 McCann IL, Pearlman LA.
Clinical characteristics of women with a history of childhood abuse. Psychological Trauma and the Adult Survivor. Prevalence and clinical characteristics of domestic violence in primary care internal medicine practices.
Currently, red viagra side effects most patients are identified by abnormal iron studies on routine screening chemistry panels or by screening family members of a known patient. Other more organ-specific symptoms are arthralgias and symptoms related to complications of chronic liver disease, diabetes, and congestive heart failure. When identified in this manner, patients typically have no symptoms or physical findings.
8. What are the most common symptoms in patients with HH?. Nonetheless, it is useful to be aware of the symptoms that patients with more established HH can exhibit. 6. Describe the most common physical findings in patients with HH.
Typically, they are nonspecific and include fatigue, malaise, and lethargy.
Cocaine and amphetamine increase red viagra side effects extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene. (1994). American Journal of Physiology 144, 597–614. Journal of Neuroscience 20, RC181 (1-4) red viagra side effects.
Carelli, R. (1997). Carboni, E., Spielewoy, C., Vacca, C., Nosten-Bertrand, M., Giros, B., and Di Chiara, G.
SN-28-glucuronide is a detoxified metabolite that can be excreted into bile red viagra side effects via cMOAT. Irinotecan is metabolized by carboxylesterase-2 to the toxic metabolite, SN-8. Increased concentrations of SN-8 in the intestine are thought to be the cause of the delayed-onset diarrhea associated with irinotecan, whereas glucuronidation of SN-8 protects against this toxicity.
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S., Zeitlin, red viagra side effects G. C., Schaffer, R. Electroencephalography and Clinical Neurophysiology, red viagra side effects 32, 31–12. Gevins, A.


text:
Win gumballs for life from O.C. firmJuly 26th, 2012, 2:00 am by Jan Norman, small-business columnist
Companies will go to great lengths to get people to like them on Facebook, follow them on Twitter, post them on Pinterest or sign up for their online newsletters.
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On Nostalgia
While I should be writing my dissertation, which, I'm learning & realizing, just as I've read all over the place & have been told countless times by peers & mentors, is mostly a psychological struggle, I am instead feeling terribly nostalgic & melancholic. I would like to write an essay about this at some point but if I did that now, I'd feel guilty for not working on the dissertation. So, some quick notes:
First/New Chapbook published by & available through Red Bird Chapbooks!
52 pages
7″ x 7″ single signature chapbook w/ hand-sewn binding
Publisher: Red Bird Chapbooks
Date: March 2016
An eclectic and energizing collection of poems, essays, and experimental fiction, Jason Magabo Perez's Phenomenology of Superhero explores the Filipino American experience with a voracious intelligence and an indelible voice. Fiercely interdisciplinary, Perez's work explores the relationship between power and otherness in American life, focusing here especially on the relationship between discipline and art, ultimately coming to an "anti-disciplinary" vision of creativity. Touching on such diverse enthusiasms as Michel Foucault, Wolverine of the X-Men, Jorge Luis Borges, Eazy-E, Sara Ahmed, and Buzz Lightyear, this brave chapbook offers every reader something to relate to and something to be challenged by.
Jason Magabo Perez's writing invites us to inhabit two time zones—the child's world of immediacy, where everything is now and here, and the grown-up's world of discipline, progress and punishment—and it powerfully reminds us of how much is at stake when we abandon the former for the latter.
– SARITA SEE, author of The Decolonized Eye: Filipino American Art and Performance and Executive Director of the Center for Art and Thought
"We think, we body. We have come." Jason Magabo Perez's Phenomenology of Superhero critiques the kindergarten coloring book of white hetero-normative heroisms. The iconic shapes of Buzz Lightyear, G.I. Joe and the Marvel universe are familiar skins, and Perez shades across their outlines, revealing the traces of discipline underneath language, colonization and power. This book witnesses Perez "lay the crayon on its ribs" and draw the spilt insides of the Filipina/o body in its own im/possible dance.
– JAI ARUN RAVINE, author of แล้ว and then entwine
Jackmovin 10/10
We read the book soaked in the basin where the fish used to swim.
I want her to stay away or simply say bad words since I am no longer excited about the oven.
I'd like to leave somewhere but there is an inscription on my skin:
You are as misleading as prayer.
This poem is 10/10 in a series. Read the description of the series:
Jackmovin: Poems & Nonessentials for the Lovestruck (2006)
Jackmovin 9/10
She walks around mocking
what is mine. I catch my breath–
a random consequence, she cries.
I have hell
in my head even as she is still
awake, not striking at all,
to strangers underneath freeways:
The dimensions of God.
A page wants to be written.
I want to say she resembles a maniac
pink, crucial
to this melodrama
that has nothing to do with love
or politics.
This poem is 9/10 in a series. Read the description of the series:
Jackmovin: Poems & Nonessentials for the Lovestruck (2006)
Jackmovin 8/10
I have lost my hand
in your hand.
The theatre of impatience:
When in your life you feel like talking
With rain in your mouth.
I like your voice sharing the same error as nature–
Purity is a cry of sweating paper.
Leaving styrofoam in a shoebox, I write
the poem we seek.
This poem is 8/10 in a series. Read the description of the series:
Jackmovin: Poems & Nonessentials for the Lovestruck (2006)
First Semester Blues: Diaries of an Adjunct, November 30, 2006, 2006 (6/6)
I do not teach Freudianism nor do I have any intention to obsess over an Austrian neurologist. No intention today, that is. It is the end of the semester. This morning was our last formal class meeting before the Final. I would like to celebrate that I have finally found an identity: I am a Filipino American Greek Thought Instructor.
Jackmovin 7/10
No, my eyes are not the sky
where that old woman lives.
But tiredness determines my life.
Black ink in circles appears
to be common practice—
America means you can't wash
it away: warm cappuccino, the safest
investment, the sanctity of delirium.
Memory for me is nothing but
a magician moved halfway
to the afterlife. This happened long ago
this morning, when you were falling
out of sentences and down the stairs
where I am forever
thinking of doing nothing.
This poem is 7/10 in a series. Read the description of the series:
Jackmovin: Poems & Nonessentials for the Lovestruck (2006)
New Poetry at The Feminist Wire!
Perez, Jason Magabo. "Loving You, Praxes For." The Feminist Wire, November 11, 2015.