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Replacement Model:
Abt Card
FlexShopper - Weekly payments as low as $
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Energy Star Rated - No
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(based on 164 reviews)
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of respondents would recommend this to a friend.
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Most Liked Positive Review
looks great!
love the way this fits into my remodeled kitchen.and the appetizer drawers are great for party prepping (now I need to host a party!)the ice...Read complete review
love the way this fits into my remodeled kitchen.and the appetizer drawers are great for party prepping (now I need to host a party!)the ice and water in the door has been used every day for the last month, very happy to have that option.cannot say enough, lets see how this holds up in the coming years.
Most Liked Negative Review
Nice and Quiet. Great temperature control, but not as roomy
Great refrigerator, but not as roomy as one would expect. My old fridge was also a Whirpool, side by side, same cu. ft., but I feel I was able to get...Read complete review
Great refrigerator, but not as roomy as one would expect. My old fridge was also a Whirpool, side by side, same cu. ft., but I feel I was able to get more things inside. Even though the french doors make for more space left to right, you really do not have that much space top to bottom, specially for things like Wine bottles, or Juice jugs. There is room for two gallon jugs on the door, but if you adjust the shelves to fit a Gallon or something narrower, but as tall as Gallon jug, you are left with not much room for anything else above or below... Same thing with the freezer. I am also disappointed that the top basket on the freezer does not slide out when you open the freezer. If you did not know it was there, you would miss it completely.The unit is quiet and more energy efficient, but overall, I am not sure I would recommend buying this particular model, particularly if you buy often at big box stores (unless you have a separate freezer to hold the overstock).
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Reviewed by 164 customers
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Great capacity!
By Lauren
from MD
Comments about Whirlpool Gold Black French Door Bottom Freezer Refrigerator:
We bought this in December 2015. Love the capacity that this offers and were able to fit a lot of food in both the fridge and freezer. Only negative we have is when you open the door, it stops the flow of water/ice. Cannot easily open and close the left side by itself. Sometimes the ice maker gets jammed and ice stops making/coming out.
Bottom Line Yes, I would recommend this to a friend
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Comment on this review
(2 of 2 customers found this review helpful)
So Sad and Disappointed
By Sadbuyer
from Los Angeles, CA
Tomorrow I am replacing this very beautifully designed refrigerator that lasted only 7 1/2 years. The control panel went out twice (after warranty) and then the compressor went out and would cost approximately $900 to replace. Our repairman said it was a common problem re the compressor. Given the thread of commonality in the other reviews, I can't say Whirlpool is top notch in this department.
Bottom Line No, I would not recommend this to a friend
Nicely spaced out
By Laitanyc
from Jersey
With the exception of an ice maker issue that was resolved within warranty timeframe we have really enjoyed this fridge. Does what a fridge n freezer is suppose to do!
Does the job
By Flafan
from Tampa, FL, United States
This model does the job. Nothing "Wows" me. It is everything I expected-so far.
Nice refrigerator, great features
By electro
from north coast, ohio
I'm happy with the refrigerator, I wish it had more space for tall objects.
Nice layout of interior draws
By Msmatercard
from Campbell River, BC, Canada
I would have rated this product a five star if the freezer drawer closed easier. It is a big drawer and requires to be pushed in with two hands.However the interior of the fridge is amazing and the ice water with filter is great!
Very Dependable!!
By Bruce7968
from East Orange, NJ, United States
I brought this back in July and its doing Great!!. Large capacity in the refrigerator and the bottom freezer.
(3 of 3 customers found this review helpful)
By noice
from Indiana, United States
Have had my frig for a year now. Was never happy with the small amount of ice it makes [my old GE made twice as much]. Thank goodness we own a restaurant where I can easily obtain ice for large gatherings or I would be even more upset. But now [of course the warranty just expired] the ice machine doesn't work at all!
great fridge
By beck2014
from Atlanta, GA, United States
We purchased this fridge because of the french door design. I am very happy with it and really like the freezer on the bottom. If I had one complaint about this fridge it would be that it doesn't make enough ice and it takes too long to dispense. Other than that I love it!
By lori4se
from Belleville, IL, United States
I love this frig. Took me a few days to adjust the shelves so I could get everything in it but love it. Nice and cold. Ice maker is a bit noisy though.
Delivery is subject to reasonable access to the area without damaging the purchaser's property or the product, or jeopardizing the safety of the delivery personnel.
Fill out the form below to request Better Price for this product.
your next order of $250 or more.

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Training Programs
We at the Christian Counseling and Training Center (CCTC) believe God's Word has relevant answers to the issues we face in daily living.
We study the character of God, His holiness, His grace, and God's purpose for life. As we examine our intimate relationships, we look at the emotions of anger, fear, and guilt within the context of the Biblical concept of love. We evaluate actions and the motives behind those actions and explore how change takes place.
We offer two levels of courses:
The Discipleship Training Classes help you develop a clearer Biblical world view and better understanding of your place in God's kingdom.
The Biblical Ministries Training Program involves a two year program of further study and a mentoring process that applies the principles taught in the first level.
101 Biblical Problem Solving
An intense "self-examination" experience in which one examines such issues as the source
of problems, self esteem, trials, love, anger, fear and change.
102 Building Biblical Relationships
We live in a culture that teaches us a great deal about prosperity, success, and the need
to understand ourselves but has little to say about building and maintaining decent, life-giving
relations. This course offers valuable insight into what God says about relating to the people
around us and covers topics such as singleness, the roles of husbands and wives, forgiveness and
tough love.
103 The Study of Scripture for Life
How do I understand Scripture that I might Biblically work through my own difficulties as well
as be an encouragement to others? Scripture for Life addresses these issues and teaches principles
of inductive Bible study while using a workshop approach.
201 Study of Scripture for Ministry
This course focuses on the application of Biblical concepts to counseling situations. Lecture,
discussion, and weekly workshop sessions provide practical, understandable ways to interpret and
apply Scripture. This course is only offered in the Fall quarter.
202 Framework for Biblical Ministry I
This course provides a Biblical framework with which to make connections between Biblical truth
and issues such as: the nature of our call to counsel one another as Christians, the relationship
between emotional problems and spiritual problems, the experience of a true change of heart, the
counseling of non-believers, and the presentation of the Gospel in the context of a counseling
relationship. This course is only offered in the Winter quarter.
203 Framework for Biblical Ministry II
Building on concepts learned in Framework 1, and teaching the students how to use them in
counseling. A case study approach in which the student reviews Biblical Problem Solving and analyzes
a set of BPS homework papers. This approach emphasizes the development of analytical skills in
understanding problems and the application of Biblical principles to solve those problems. The
student is required to continue to learn appropriate Scriptures for counseling. This course is
only offered in the Spring quarter.
301 Methodology for Biblical Counseling I
We may know what many of the concepts of Biblical counseling are but struggle as to the practical
application of these concepts. Methodology for Biblical Counseling I provides a broad methodological
process for counseling. One purpose of this course is to show the student how to plan and manage a
counseling case. Topics covered to teach the student to lead a counseling case include planning and
execution of each successive session as it moves toward completion. Lecture, group discussion and
case studies are the approaches used. The student is expected to take part in all discussions.
302 Methodology for Biblical Counseling II
Building upon principles and process taught in MBC I, students learn how to apply these concepts
within specific areas of counseling. The student is taught how to begin a case through an assessment,
how to plan and direct the sessions week to week, and how to complete the case. Special types of
counseling issues are discussed in this course such as depression, anger, suicide, substance abuse,
psychosis, etc. Lecture, group discussion and case studies are the approaches used. The student is
expected to take part in all discussions.
303 Methodology for Marriage Counseling
This course offers specific direction on how to counsel married couples. Each session provides
tools and illustrations to provide help for each marriage partner to walk closer with God and thereby
grow into becoming God's representative in their marriage relationship. Biblical counseling models
are introduced and illustrated through various counseling case studies. This course addresses "idols
of the heart" and the motivation behind developing six relational skills. Homework consists of
studying Scripture, application exercises, and reading chapters in the text to prepare for group
discussion. Lecture, group discussion and counseling case studies using the information presented
are the approaches used.


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No products
₹ 4,299 Décathlon
short urban journeys and rides. Height: From 1.45 m to 1.85 m.
Compact scooter with large wheels that is perfect for short journeys and outings. Go 3 times faster and 3 times further than on foot!
Great product
light weight yet sturdy. My son is driving one since the age of 4 years. Now 7 years old.
Smooth drive and adjustibility
No replacement of handgrip
My son looking for side support stand attachment to make it more convenient in parking lot. Should be provided atleast as accessory.
Good adjustment and braking
side stand non availability
Product is very Good... But the scooters were not available in the colours of choice - in the sense - within the limited number of colours offered, the one that my son liked was not there. My impression from the discussions over there is that until all pieces gets sold, it will not be replenished - indirect pushing of the slow moving colours. Its not fair on your customers.
Dear Dattari,
Thank you for taking the time to your review on our Oxelo MID 7 scooter. This model is available in three different colours which are Blue, Black & Pink. We are really sorry for the unavailability for the particular colour wich you were looking for your son. We don't push slow moving product or something similar, it is just due to availability of our stock. I will get back to you for the solution of this very soon.
Thank you again for writing us on the way to improve our service.
Prateek Gondane,
Commercial & Communication Manager, Oxelo
Good service
No stand
Excellent service all round
Bought it for my grandson he loves it
I'm to old to ride it
Super scooter great for the children, easy to build, easy to maintain, loved it!
Children loved it! Great scooter, great fun just p
Bought this for my 8 year old son. Brilliant scooter for the price. Very robust, good bearings, reasonable weight. Cant fault it really.
9 year old loves her new scooter,used every day to go to school.
Stable,Carry strap,quick assy
So good and so much fun that my kids are fighting for a chance to ride it.
Looks very high tech and modern design
Did not discover them yet.


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Some commonly asked questions
The next step is generally the instrument rating. This allows you to fly in the clouds!
Once you have acquired at least 250 hours of flight time, a Commercial Pilot's License is generally next. This allows you to be hired to fly. Initial jobs might include flying skydivers, hauling cargo, or crop dusting.
After Commercial, many people take their Flight Instructor exams and begin teaching others the joy of flying.
To fly for the airlines, corporate, or other large-aircraft operators, you will need your Multi-engine Airline Transport License. For this you will first need to accrue 1500 hours of flight time.
To start Part 61 flight training, you can either begin with ground school, flight training, or both simultaneously. Please visit the Private Pilot Course page or Sport Pilot Course page to view the training outline. In order to take the final test to earn your license, you'll need to complete more than just flight training.
- FAA written test
- Student Pilot Certificate/Medical (same document)
- FAA checkride (oral and practical portion)
To pass the FAA written test, you'll need to complete Ground School or a home study in order to get the endorsement to take the written test. The FAA written test is based off the content of the Pilot's Handbook of Aeronautical Knowledge, you'll also want to access the Airplane Flying Handbook to learn how to execute aircraft maneuvers.
To get your Student Pilot Certificate/ Medical, just make an appointment with your local Aviation Medical Examiner – Find one here
AeroDynamic Aviation requires Aircraft Renter's Insurance for students and renters to fly solo. The required coverage is $20,000 in aircraft damage liability. We suggest Aviation Marine, AOPA, or Avemco for insurance brokers.
In order to get endorsed to take your checkride, you'll need to show your instructor you can perform the various maneuvers up to FAA standards, found in the Practical Test Standards.
Finally, we'll set up your checkride with a Designated Pilot Examiner.
- Initial license (Sport, Private, or Commercial)
- Instrument Rating
- Multi-Engine training
You DO NOT need TSA clearance for:
- Commercial
- CFI (Certified Flight Instructor) training
To rent at AeroDyanmic Aviation, you'll need to provide the following:
Renter's Agreement
Pilot's Certificate
Aircraft Renter's Insurance (minimum $20,000 aircraft damage liability coverage)
Aircraft Checkout – The checkout will consist of the ground portion covering the aircraft review form and a flight checkout reviewing basic certificate maneuvers
For renters out of our San Jose location, we offer block rates to fully paid up members in good standing. Block prices assume 10% credit has been earned. Reid-Hillview members in good standing who maintain a positive balance earn 10% credit for check or cash prepayments (7% for credit cards) of $500 or over.
For those guests who have a specific time frame they would like to fly in, we highly suggest pre-booking your flights. Contact the office at email@example.com to set up your schedule. A security deposit will be required to hold your spot.


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World radio tv handbook 2014: The directory of global broadcasting (Paperback)WRTH Publications Limited
Paperback Published: 12/12/2013
- Not available
In the 68th edition of WRT Handbook, this great directory continues to offer the most comprehensive guide to broadcasting on the planet. Completely revised and updated, this new edition is the most accurate guide to national and international SW, MW, and FM broadcasting available. The World Radio TV Handbook is divided into a number of sections covering numerous topics, from National Radio - which looks at the world's domestic radio services, listed by country and including contact details, to International Radio - featuring full facts about all broadcasters transmitting internationally; and from Television Broadcasts - which details the world's main national broadcasters and large regional networks to frequency lists of all MW and international and domestic SW broadcasts. Also included in this revised edition is a reference section that contains listings of international and domestic transmitter sites, standard time and frequency transmissions, DX Club information, as well as other essential print and electronic resources.
Publisher: WRTH Publications Ltd
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5 Blog Tips for Success: Guaranteed
Ten Blog Tips How to Make a Big Splash with your Blog and Impress the Hell out of Everyone: All Hail to the Power of Zen …
Warning: This post belongs to the Bloke's 'Just for Fun Series', so if you have no sense of humor then please refrain from reading any further. Rory has written an interesting post about recent newcomer Leo Babauta who has quickly made a name for himself in the overcrowded blog about blogging niche, leaving bloggers shaking their heads how he did it.
So I thought it would be fun if I wrote a tongue-in-cheek counterpoint to help dispel any speculation and give you my insight as to how he might have done it.
These are my observations in a nutshell:
- Make a HUGE splashy banner. Be bold. Be very BOLD. Later, when your blog is more established you can replace the big banner with even splashier advertisements.
- Write in very (very) LARGE print. Did I say LARGE? The advantage with this strategy is that you can fill up the page using less words. In addition, the sight impaired need not use their scroll button to make the print larger to read. It's already done for them. Speaking of writing, be sure to throw in an impressive buzz word now and then to keep them guessing and running over to Wikipedia. Who knows, while they're over there they might write an article and make you immortal. Stuff your titles with outrageous superlatives that are sure to attract swarms of viewers like flies on doo doo, such as "Superblog" or "Pure Gold"… keep your thesaurus handy and remember that BOLD thing.
- Use a simple template design. The advantage with this strategy is that it only takes a few minutes to prepare your template and who cares if it looks like it was made using Microsoft Word.This strategy will only be effective if you tell everyone that they should also do the same to hide the fact that you have no coding skills whatsoever.
- Only allow the cheering section to leave comments. Forget about blogging transparency and delete with extreme prejudice any comments that might offer a different opinion… especially if it comes from the competition. (Coming from bitter personal experience :).
- Glean the best information that you can find from the internet. Repackage it with all the flair that you can muster, applying CMP (Copy, Massage and Paste) and your best copywriting skills. Prepare a bunch of posts in advance and orchestrate your big splash by scheduling them for release one right after the other.
That should impress them.
P.s.: This post was made in fun. Please note the tags "humor" and "satire". Get it? So don't bother sending hate mail. You will have to stand in line for that.


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Please contribute a report! To add a new field report, click on the "New post" button below (if you can't see the "New post" button, you may need to sign in through the link at the bottom of the page). Before posting, see the Field trip report guidelines. If you want to be alerted when new Field Reports are posted, click on "Subscribe to posts" below.
Field Reports
Strawberry Plains Audubon Center Field Trip
On Saturday April 30th, the Ole Miss Office of Sustainability sponsored a field trip to Strawberry Plains for about 20 students. When we arrived at the center, we were greeted by Mitchell who was to be our guide for the day. The weather was drizzly and overcast but not too troublesome for us. Mitchell took us on a small tour of the property, showing us the area where the hummingbird festival is held and pointing out a huge tree that had just fallen two days previous. We saw the structures that have been built for CHIMNEY SWIFTS to roost and nest in and Mitchell explained the importance of these structures for these birds that are not able to perch as most birds do. We walked through an open building that was once used for buying and selling cotton and learned about how Strawberry Plains was founded. The property was left in Audubon's care by the owner after her husband's death. We were able to go inside the antebellum home on the property which is now available to be rented for events. Afterwards, we visited the vernal pools on the property which are small pools that will dry up after the rainy season. Here, Mitchell used a net to try to scoop up small critters from the water. We were mainly interested in salamanders but we found CRAWFISH, DRAGONFLY LARVAE, and other water insects. We finally managed to capture a few juvenile SPOTTED SALAMANDERS. We followed this by a very delicious lunch provided by Living Foods and a presentation with a more in depth look at the history of Strawberry Plains. As we were on our way out, Mitchell took us a short way into the woods to show us a tree with very clear BLACK BEAR claw marks all over it which was very cool to see. It was a really fun and educational trip and now I am very interested in going out to volunteer at Strawberry Plains as they are always in need of helping hands!
Here is the e-bird checklist for the trip:
North side of Sardis Lake looking south
It had been a pleasant day with nearly cloudless skies and a slight breeze to compliment the restless waves within Sardis. Over a dozen CHIMNEY SWIFT were overhead nearly all day going back and forth from tree to tree. I was with both my mother and step-sister outside of our cabin overlooking the lake, which was busy with the college semester coming to an end and mother's day. The property itself had experienced considerable reconstruction efforts after a house fire and with over a year of work a new house stood where an old cinder block cabin had been. But with reconstruction for all practical purposes being completed, life had gradually returned to the property. A lone RED EYED VIREO sang in the distance towards the northern woods which was eventually drowned out by a small congregation of FISHER CROW gathering on a nearby tree adjacent to the property. With such beautiful weather, the lake was sure to be busy and sure enough with such a large expanse of water there was something on the hunt along the shallows. An OSPREY made quick pass by the front of the property facing the water but soon was out of sight and likely looking for intently for some kind of meal. Several fishing boats and pontoon boats were out and even a lone sail boat with a crisp white sail had made it to the center of the lake with the breeze pushing it along. Eventually the forest surrounding the cabin and the trees leading to the lake broke into a harmony of various calls and shrills. The sharp upward trill of the NORTHERN PARULA, the rapid chip of the CHIPPING SPARROW, the bbzzzttt's of the fluttering BLUE-GRAY GNATCATCHER. All of it rang together into the background as is expected with such beautiful weather and that would likely continue into the summer. As we all sat quietly soaking up sunlight and fighting off the occasional mosquito, a bright red blur flew past us all and landed quietly in a low hanging branch of a nearby tree. Apon closer inspection the blur was a SUMMER TANAGER fresh with a new coat of feathers all vibrantly red. Eventually the singing of the birds began to slow and listening to the woods surrounding us the call of two EASTERN WOODPEEWEES going back and forth became apparent and listening even closer the call of the WHITE EYED VIERO became pronounced and began to come closer as we listened. For quite some time the calls of the vireo dominated everything else so we started to look closely for anything that may have escaped our notice. Sure enough next door a pair of NORTHERN MOCKINGBIRDS were in the neighbors yard searching for food. A lone mockingbird flew past them with an angry call and then disappeared. As we began to tire we gathered our drinks and sunglasses and then began to retire inside to escape the sun and have a late lunch. As we began to walk back inside a small group of TURKEY VULTURE glided lazily above us and just as quickly disappeared into the tree line. Overall the birding was peaceful and made for a beautiful Mother's day that will always stay in memory.
White-eyed Vireo Mimicry and a Little Mystery (almost) Solved
In a previous post last year I described the repertoire of a White-eyed Vireo individual who sang continuously for me for 45 minutes one morning at Rowan Oak. In that singing session he displayed 10 distinct song types. In response to that post a fellow birder commented, somewhat offhand, that when he moved to Mississippi from Florida he thought the White-eyed Vireos here all sounded strange. When I asked him to elaborate, he said that the vireos here seemed to all use these "gargly notes" that were absent among the Florida birds.
"Gargly notes"? Hmmm.
After some additional conversation I had a guess for what notes he was referring to. Listen for the laughing/chattering/stuttering sound in the middle of this White-eyed Vireo song, just before the "whine". LISTEN HERE
Hear it? It's sort of a rapid tut-tut-tut. That is apparently the sound my friend was referring to. First, kudos to my friend for noticing the qualitative difference these notes add to WEVI songs around here. But, why wouldn't WEVIs in Florida sing these notes too? Well, to begin with, not all WEVI songs incorporate these notes. So, maybe he is just mistaking the coincidence of his noticing it for the first time in MS for the absence of these notes in FL. That is a distinct possibility.
Giving him the benefit of the doubt, though, what else could be the explanation? Well, it's a lesser known fact that White-eyed Vireos are mimics. In fact, their songs are chock full of mimicry. Hadn't you noticed? You can be forgiven for not noticing. Unlike the Northern Mockingbird (and many other mimics) WEVIs don't mimic the songs of other species. Instead they collect call notes from other species and weave them into the distinctive song that we associate with the White-eyed Vireo, full of ticks, whines, stutters, and all manner of rather unmusical phrases imbued with a very definite rhythm.
So, supposing that this is a mimicked sound, the first thing to do would be to see what species that sound belongs to. Some of you who pay more attention to the calls of our resident breeding birds may recognize this call already, even if you can't quite put a name to it. It's one of the calls of the Wood Thrush. Here's the call given by it's "rightful owner": LISTEN HERE.
At this point I have determined that the "gargly notes" are a Wood Thrush call that has been appropriated by White-eyed Vireos. I have also noted that my friend recognizes this sound as distinctive of Mississippi vireos relative to his central Florida White-eyed Vireos.
This is where the story gets more interesting. Wood Thrushes don't breed on the Florida peninsula. They are neotropical migrants, spending our winter in southern Mexico and Central America. They migrate north to breed across much of the United States, excluding coastal Louisiana and the peninsula of Florida. I checked the WEVI songs posted on Xeno-Canto from Florida and indeed could not find one with the thrush call included in the songs (as of my perusal last year). This doesn't seal the deal by any means, but it suggests that perhaps my friend is right that the Florida birds lack these Wood Thrush notes. It's plausible if young WEVI learn the mimicked phrases of their songs primarily within their breeding range. If so, the birds hatched in Florida would be unlikely to pick up Wood Thrush song elements. I'm not sure anyone has investigated this.
So, a little mystery (potentially) solved.
Birding at Rowan Oak and Bailey's Woods Trails
Birds, Fungi, and Quadrupeds Galore at Wall Doxey State Park
On May 1st just after lunch, my friends and I decided to venture out to the realms of Wall Doxey State Park with hopes that the dissipating rain clouds and the bluing of the sky would make for a memorable hike around the lake--and that, it was. From the start of the hike around the lake, the birds were noticeably more active than in the past couple of days. Common birds were immediately heard by their calls, including TUFTED TITMOUSE, NORTHERN PARULA, RED-EYED VIREO, NORTHERN CARDINAL, and BLUE-GREY GNATCATCHERS. Just around the lake's edge when walking around clockwise from the parking lot, one could distinctly hear a LOUISIANA WATERTHRUSH, which is the same location where I had first seen it rather than just hear its call. As we made our way into the wooded area, we found an assortment of fungi that we could not identify (but took pictures to ask Dr. H later), salamanders under logs, frogs and toads hopping from puddles, a mothering beaver, and even a pair of turtles in the bout of a courtship ritual. After all of these great finds, we continued onward with our birding, where we came across a couple SUMMER TANAGERS, a hammering RED-BELLIED WOODPECKER, followed by its family member--PILEATED WOODPECKER. It was a great day enjoying nature's pleasantry before the busy weeks ahead near the end of school. From this trip, I do want to emphasize to everybody to heed the dangers of ticks because I was bitten by a tick that transmitted the symptomatic rash of a Lyme-like disease.
Other species seen:
Photos of the trip can be seen with the following links:
Birding with Sibley!
Meghan McNeill & Adam Smith
April 30, 2016
Early Saturday morning a few of us from Dr. Hoeksema's ornithology course had the pleasure of birding with David Sibley. Mr. Sibley is one of the most prestigious ornithologists as well as artists in the United States. He is known for his phenomenal birding field guides. My fellow classmate Adam Smith and myself were in the 8:30 group to bird at Rowan Oak for an hour. Fortunately, we were able to avoid the rain for the majority of the trip, but the birding was slow due to the inclement weather making way.
Although the birding was slow, Mr. Sibley's plethora of knowledge was exciting. He was informative on bird psychology, and educated us on some new birding facts that we had never heard before. For example, he was able to begin to form a possible explanation for the "confused" AMERICAN ROBIN who resides in the Rowan Oak area that has a half AMERICAN ROBIN-half- CAROLINA WREN song. Mr. Sibley said it is possible the Robin had learned the call during its juvenile years in the nest, if the nest was nearby a CAROLINA WREN's nest.
It was a pleasure to bird with fellow Mississippi birders from around the state in our home stomping grounds. Other notable birds we observed were SUMMER TANAGERS, ROSE-BREASTED GROSBEAKS, and many CEDAR WAXWINGS. If you would like to view our list of birds identified by sight and sound, you can follow our link to the eBird checklist.
April 30, 2016 Birding Trip
Saturday morning, April 30, I went out to the Clear Creek Recreation area at Sardis to go on a short birding expedition. To my surprise I immediately observed five WILLET's congregated on the shore at the boat launch. WILLET's are not common in Lafayette county, but can be observed on the Mississippi Gulf Coast. To be honest with you, I was unable to identify the exact species and had to be assisted by bird expert, Dr. Hoeksema, my Ornithology professor. Luckily, I was able to snap a few (poor quality) pictures of the shorebirds before they flew off.
Other than the shorebirds, I also observed PURPLE MARTIN's in the provided bird houses at the boat launch, and of course some CHIMNEY SWIFTs gliding overhead. While driving, I observed a few other bird species, which among those already mentioned, you can check out on my eBird link provided below. http://ebird.org/ebird/view/checklist?subID=S29301704
Birding at Rowan Oak on April 28
This morning Dr. Hoeksema escorted fifteen members of our Ornithology class to Rowan Oak for a birding walk. We arrived at Rowan Oak around 7:45 am and departed around 10:15 am. It was a sunny pleasant morning. We began in the west lawn which was brimming with birds. Here we saw several ROSE-BREASTED GROSBEAKS and SUMMER TANAGERS. We were lucky enough to have a BROAD-WINGED HAWK fly in and perch in a leafless tree nearby, surveying the area and doing some preening. She hung around for quite a while so we were able to get an excellent look.
We also got a good look and listen at a few GRAY CATBIRDS hanging about. As we ventured around the property, we noticed a baby rabbit sitting in the leaves under a tree only about five feet away from us. She seemed very calm and allowed us to get close for a good look at her adorableness. Soon after, we came across a turtle on the lawn who was not very excited about being picked up and examined. She zoomed away at top turtle speed as soon as we set her down. We continued our walk into Bailey's Woods to search for warblers which were fairly plentiful. There were many birds moving about high up in the canopies so it was a little tricky to get a bird in the binoculars. We had a decent look at a few AMERICAN REDSTARTS and further into the woods we heard and got glimpses of BLACK & WHITE WARBLER, BLACKBURNIAN WARBLER, TENNESSEE WARBLER, and CHESNUT-SIDED WARBLER. We also noticed two COOPER'S HAWKS some distance away. As we were crossing the bridge by the creek, we got a great look at a YELLOW-BILLED CUCKOO hopping around in a tree. Overall, it was a successful trip with great looks at grosbeaks, tanagers, catbirds, and a cuckoo and a truly incredible look at the broad-winged hawk.
Here is the e-Bird checklist for this morning:
Birding at Rowan Oak
Once a week our ornithology class visits Rowan Oak and Bailey's Woods, a small patch of forest in the center of Oxford. On Thursday, April 21, the weather was dreary, but we all loaded up into the vans for the short drive across town, hoping that the blanket of clouds might dissipate rather than darken. When we arrived at Rowan Oak, the class stood around the vans listening for what birds were most immediately identifiable. There were RED-EYED VIREOS and BLUE-GRAY GNATCHERS, some CHIMNEY SWIFTS twittering overhead, NORTHERN CARDINALS and BROWN-HEADED COWBIRDS.
As everyone keyed in on the most common calls, we set out walking around the property. The lighting was poor, which made it challenging to identify birds in the tops of trees, against the backdrop of white sky. So we practiced listening and scanning for birds against the green of dense foliage along the forest edge and in its understory. One of our classmates was awarded a prize for identifying a species that the class had not before seen: an ORANGE-CROWNED WARBLER perched among a messy tangle of vines.
After having all gotten a look at a male SCARLET TANAGER, a WOOD THRUSH, and a small group of TENNESSEE WARBLERS, we began our walk into the woods from the open lawn. Pausing atop a gully's edge we listened for a BLACK-THROATED GREEN WARBLER, but we never sited the bird. However, in searching for the warbler, we came very near a male ROSE-BREASTED GROSBEAK foraging in a slender tree.
The highlight of the trip, however, was on the latter portion of the trail. From our place on top of a high ridge, the class got a great (though brief) look at a BLACKBURNIAN WARBLER. Then, it was mostly more of the same species we see and hear each week: the CAROLINA WREN, the LOUISIANA WATERTHRUSH, etc.
As it began raining, we started back toward the trail's entrance, but not before Dr. H pointed out a large orange fungus twenty feet from the path. PALE CHICKEN OF THE WOODS is what he called it. As he picked a handful, he told the class that this was one of the several local species of edible fungi, best served fried. Several of us took his word and picked our own pocketfuls to try.
The walk back was far less eventful than the walk in, likely because we were all eager to get out of the rain. Once we reached the trail's entrance, Dr. H suggested breakfast at Bottletree Bakery, so we ended our morning of birding with pastries and hot coffee.
Here is the eBird checklist for that morning: http://ebird.org/ebird/view/checklist?subID=S29097972
Birding at Coldwater River National Wildlife Refuge
John Mathis and Nishant Rout
Dr. Hoeksema's Ornithology Class left Oxford at 7:40 a.m. on a beautiful day on April 26, 2016 to Coldwater River National Wildlife Refuge in the Mississippi Delta. It is located just outside of Crowder, MS. The group consisted of 15 undergraduate students, 1 graduate student, and 2 college professors. We arrived at the refuge at about 8:25 in the morning. The skies were mostly cloudy with a 7 mile per hour wind and a temperature of 71F.
We started by walking out to a lookout over a few lakes. When crossing the bridge, we got a good look at a bullfrog. About halfway up the walkway to the lookout, we found a ribbon snake. The photo above is of Cullen holding the snake with his usual happy face when he gets to hold a reptile. When we reached the top of the lookout, we saw lots of AMERICAN COOTS, a few groups of BLUE-WINGED TEAL, tons of RED-WINGED BLACKBIRDS, many GREAT BLUE HERONS, and a few GREAT EGRETS.
After coming down from the lookout, we got in the vans and moved to some other small ponds. There were lots of KILLDEER and LEAST SANDPIPERS. There were also a few BLUE-WINGED TEALS, a single NORTHERN SHOVELER, and a lot more COOTS. The next photo is of the group checking out a group of least sandpipers at about 50 yards. At the next pond, we got a few good looks at a few WILSON'S SNIPES flying. It was hard to see them on the ground, but when they flew, it was easy to tell they were Snipes by their impressively long bills. We also got a very good, up-close look at a few SOLITARY SANDPIPERS. We all could see all the characteristics very well such as the bright white eye ring and the spots on the back. We also had a couple LESSER YELLOWLEGS at that spot and 1 EASTERN MEADOWLARK.
We then continued down the bank in the vans to see what was at the back of the property. On the way, we saw a cotton mouth right on the bank of one of the ponds. Cullen, of course, leaped out of the van in an attempt to catch him on a stick but was not fast enough. At the very back we saw a few INDIGO BUNTINGS and heard a PROTHONOTARY WARBLER. There was also 2 RED-BELLIED WOODPECKERS. On the way out, we had 3 white-tail deer running right along the woodline with the vans.
Unfortunately, we had to leave pretty quickly to get back to Oxford on time. We were able to spend about an hour and 15 minutes at the refuge. However, we were able to get a lot of good looks at birds that many people in the class had never seen before such as Wilson's snipe and Eastern meadowlark. Also, it was good to be able to get so close to the solitary sandpipers and observe their distinct characteristics.
eBird checklists:


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The UFC returns to free television this Saturday with UFC on Fox 8, and we are taking a look at the odds heading into the final card of July.
The event features a flyweight title fight between champion Demetrious Johnson and top contender John Moraga, while the co-main event is a welterweight contest between contenders Jake Ellenberger and Rory MacDonald.
For those looking to get a bit more involved in the action, the betting lines for the main card fights are in, and we've got all the odds right here.
Find out where the value lies for this card as we handicap all four main card fights.
In advance, best of luck to everyone.
*All odds courtesy of Bovada.


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Oh, for Pete's sake! These agents have to be bored to tears with some of this stupidity!
BLIZZARD - the gaming company that makes Warcraft, Starcraft, and should be rolling out Diablo III sometime this century.
DHS — the abbreviation for the Department of Human Services, which nearly every state in the union has.
FLU — I thought I had it until I was diagnosed with a sinus infection yesterday.
TARGET — a store that has lousy checkouts but can have good sales from time to time.
SHOOTING — my daughter is a photographer. And she doesn't have an AGENT.
That's the point I was making above....it would be thoroughly possible to have a conversation about World of Warcraft that included multiple of those terms, but was 100% about the game and completely unthreatening.
Blizzard, both the company that makes the game and a Frost mage spell. Assassination, a rogue spec emphasizing a two dagger fighting style and quick transitions between fights. Shooting being the primary means for a hunter to attack their target.
It's ridiculous.


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Hint: it involves shopping.
It's the internet equivalent of a friendship bracelet.
It's dry season.
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Courtesy of Toronto's new cozy snack spot, Pray Tell Bar.
1 day ago
Fashion Editor, Co-Founder, Talitha. London.
2 days ago
Get an even skin tone once and for all.
What happens when a bridal designer finds inspiration at the MET.
The spring runways held all the Halloween inspiration you could ever need.
Everything from fittings with models to private dinners with the Kardashians.
The actress and songwriter is out with a new EP and starring in a new, very different role.
A mummy-inspired mani courtesy of Madeline Poole.
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TeamViewer 11 is designed to run on a broad spectrum of operating systems ranging from the state of the art, such as Chrome OS, Windows 10, iOS 9, Android Marshmallow, and Mac OS X El Capitan, to older operating systems such as Windows XP.
With the release of a new main version (e.g. 11.x etc.) for Windows, Mac OS or Linux, we exchange the download links on our homepage. You will find previous versions on our website under Download/Previous versions.
Ceny a další informace o licenčních podmínkách naleznete v našem internetovém obchodě:


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Watch as Zen will be on fractal imagery on is met. Software has been converted to read, budget matched up characters from recent version of the details. Windows NT has a good health. You have to program that deletes sanitization algorithm, DoD. Allow the connected USB devices in the primary panel. Need to make any decisions by dictionary and get Windows 2000, XP image and you Software Lite offers particular and general.
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Karl Tryggvason Group
Karl Tryggvason
|08-524 877 20
Karl Tryggvason's profile page.
Karl Tryggvason´s group carries out research on the molecular structure, biology and diseases of basement membranes.
The basement membranes (BM) are specialized extracellular structures that promote cellular differentiation, migration and adhesion, and they are involved in many diseases. The group has characterized numerous BM proteins and their genes, and elucidated the molecular basis of five genetic BM diseases; Alport syndrome, diffuse leiomyomatosis, junctional epidermolysis bullosa, congenital muscular dystrophy and congenital nephrotic syndrome.
BMs are an important component of the kidney filter that is currently a major target of the group's research. The involvement of BMs in diabetes complications and tumor invasion and metastasis is also a major research focus. Furthermore, the group has carried out extensive work on matrix metalloproteinases (MMPs) and novel bacteria binding macrophage receptors MARCO and SCARA5.
Research projects
Basement Membranes involment in cancer and in stem cell differentiation
Characterization of the structure and function of BM proteins has been a central focus of the group. Type IV collagen and laminin are the main structural proteins that also have other important functions. Other important components include proteoglycans and nidogen. The group has characterized and cloned all six alpha chains of type IV collagen, nine out of eleven known laminin chains, as well as perlecan the main BM proteoglycan. Many of these proteins were first described by the group. Gene targeting in mice has been used to elucidate the biological roles of laminins and perlecan. The gamma-2 chain of the epithelium specific laminin-5 was found by the group and shown to be a remarkable marker for early detection of invasive cancers, in addition to being mutated in the skin blistering disease epidermolysis bullosa. Antibodies against laminin-5 are being tested for in vivo inhibition of cancer cell migration and dissemination. Different isoforms of trimeric laminins have been produced as recombinant proteins, and they have successfully been used in different culture conditions and differentiation of embryonic stem cells.
Selected publications
Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen.
FEBS Lett. 1987 Dec;225(1-2):188-94
Extensive structural differences between genes for the alpha 1 and alpha 2 chains of type IV collagen despite conservation of coding sequences.
FEBS Lett. 1987 Nov;224(2):297-305
Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.
FEBS Lett. 1987 Jun;216(2):281-6
Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7.
J. Biol. Chem. 1987 Aug;262(22):10454-62
Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains.
J. Biol. Chem. 1988 May;263(14):6751-8
The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
J. Biol. Chem. 1988 Nov;263(33):17217-20
The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.
J. Biol. Chem. 1988 Dec;263(36):19488-93
Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
J. Cell Biol. 1992 Jan;116(2):559-71
Structure of the human laminin B1 chain gene.
J. Biol. Chem. 1990 Sep;265(26):15611-6
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.
J. Cell Biol. 1992 Nov;119(3):679-93
Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues.
J. Biol. Chem. 1994 Sep;269(37):23013-7
Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.
J. Biol. Chem. 1996 Nov;271(44):27664-9
Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain.
J. Biol. Chem. 1997 Oct;272(44):27862-8
Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain.
J. Biol. Chem. 1999 May;274(20):14107-11
Recombinant laminin-8 (alpha(4)beta(1)gamma(1)). Production, purification,and interactions with integrins.
J. Biol. Chem. 2000 May;275(20):14853-9
Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.
J. Biol. Chem. 2002 Apr;277(15):12741-8
Contributions of the LG modules and furin processing to laminin-2 functions.
J. Biol. Chem. 2002 May;277(21):18928-37
Laminin isoforms in tumor invasion, angiogenesis and metastasis.
Semin. Cancer Biol. 2002 Jun;12(3):197-207
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney.
EMBO J. 2003 Jan;22(2):236-45
Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan.
Circ. Res. 2004 Mar;94(4):550-8
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.
Cancer Res. 2004 Jun;64(12):4059-63
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.
Cancer Res. 2004 Jul;64(14):4699-702
An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.
Blood 2004 Sep;104(6):1859-66
Impeded interaction between Schwann cells and axons in the absence of laminin alpha4.
J. Neurosci. 2005 Apr;25(14):3692-700
A simplified laminin nomenclature.
Matrix Biol. 2005 Aug;24(5):326-32
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.
J. Biol. Chem. 2006 Jan;281(1):213-20
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Dev. Cell 2006 Mar;10(3):397-405
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.
J. Biol. Chem. 2006 Jan;281(1):213-20
Basement Membrane Diseases
The group described the first human genetic BM diseases by showing mutations in type IV collagen in Alport syndrome (hereditary nephritis) and diffuse leiomyomatosis. Furthermore, the first laminin disease was demonstrated by finding mutations in the g2 chain of the laminin-5 isoform in junctional epidermolysis bullosa, and defects in the laminin a2 chain were shown to underlie congenital muscular dystrophy. The gene for congenital nephrotic syndrome was also found by positional cloning. The results of this work have enabled the development of DNA-based diagnostic methods for these diseases. At the present, members of the group are developing gene therapy for Alport syndrome in dogs, and they have been successful in obtaining efficient in vivo gene transfer into kidney glomeruli in experimental animals.
Some of the main complications of diabetes are microvascular changes (microangiopathy), which are thought to be the primary cause of severe diabetic kidney and eye complications. Microangiopathy may also contribute to skin ulcers and neuropathy that are frequent complications of diabetes as well. Nephropathy, that primarily affects the kidney glomeruli, has been shown to be genetically regulated. The research group carries out linkage analyses and association studies to find gene(s) that predispose to the dreadful diabetes complications. In collaboration with researchers in Finland, Iceland and Denmark, DNA samples from patients in these countries are analyzed to find loci harboring the gene(s). Identification of the diabetic nephropathy gene(s) would be of immense value for identifying patients with propensity of developing diabetes nephropathy and for improving treatment.
Selected publications
Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome.
Proc. Natl. Acad. Sci. U.S.A. 1990 Feb;87(4):1606-10
Identification of mutations in the COL4A5 collagen gene in Alport syndrome.
Science 1990 Jun;248(4960):1224-7
Complete amino acid sequence of the human alpha 5 (IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient.
J. Biol. Chem. 1992 Jun;267(18):12475-81
Alport syndrome and diffuse leiomyomatosis: deletions in the 5' end of the COL4A5 collagen gene.
Kidney Int. 1992 Nov;42(5):1178-83
Deletion of the paired alpha 5(IV) and alpha 6(IV) collagen genes in inherited smooth muscle tumors.
Science 1993 Aug;261(5125):1167-9
Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa.
Nat. Genet. 1994 Mar;6(3):293-7
Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5).
Nat. Genet. 1994 Mar;6(3):299-304
Structure of the human type IV collagen COL4A5 gene.
J. Biol. Chem. 1994 Mar;269(9):6608-14
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.
Nat. Genet. 1995 Oct;11(2):216-8
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Gene Ther. 1996 Jan;3(1):21-7
Mutations in type IV collagen genes and Alport phenotypes.
Contrib Nephrol 1996 ;117():154-71
Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain.
Hum. Mol. Genet. 1997 May;6(5):747-52
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Mol. Cell 1998 Mar;1(4):575-82
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.
J. Am. Soc. Nephrol. 1999 Nov;10(11):2440-5
Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.
Nat. Neurosci. 2001 Jun;4(6):597-604
Adenovirus-mediated transfer of type IV collagen alpha5 chain cDNA into swine kidney in vivo: deposition of the protein into the glomerular basement membrane.
Gene Ther. 2001 Jun;8(11):882-90
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome.
Hum. Mol. Genet. 2001 Nov;10(23):2637-44
Congenital nephrotic syndromes.
Curr. Opin. Genet. Dev. 2001 Jun;11(3):322-7
Molecular basis of glomerular permselectivity.
Curr. Opin. Nephrol. Hypertens. 2001 Jul;10(4):543-9
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
N. Engl. J. Med. 2003 Jun;348(25):2543-56
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure.
J. Intern. Med. 2003 Sep;254(3):216-24
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome.
Nephrol. Dial. Transplant. 2003 Jan;18(1):70-6
Nephrin promotes cell-cell adhesion through homophilic interactions.
Am. J. Pathol. 2003 Dec;163(6):2337-46
Defective trafficking of nephrin missense mutants rescued by a chemical chaperone.
J. Am. Soc. Nephrol. 2004 Jul;15(7):1731-8
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.
J. Clin. Invest. 2004 Nov;114(10):1475-83
Characterization of the interactions of the nephrin intracellular domain.
FEBS J. 2005 Jan;272(1):228-43
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q.
Kidney Int. 2007 Jan;71(2):140-5
Functional genomics of the kidney glomerulus
The human kidney contains about one million filtration units called glomeruli. A glomerulus consists of a bag-like Bowmans capsule containing several capillaries (glomerular tuft), the walls of which constitute the filter system. The plasma filtrate is led to the proximal tubule, while the unfiltered blood returns to the blood circulation. The filtration barrier of the capillary wall contains a fenestrated endothelium, the glomerular basement membrane (GBM), and the podocytes with their interdigitating foot processes. The slit diaphragm is the renal ultrafilter that is located between the foot processes. Until only recently, the molecular nature of this filter was unknown, but now nephrin, Neph-1 and FAT have been identified as its crucial components. Abnormalities in the glomerulus often lead to progressive proteinuria and renal failure that needs to be treated by hemodialysis and kidney transplantation. Our identification of the nephrin gene, that is mutated in congenital nephrotic syndrome, was a groundbraking result, as it provided new insight into the molecular nature of the renal ultrafilter, the structure of which had been a mystery for decades. Although a few slit membrane components have now been identified, many aspects of the glomerulus and particularly the pathogenesis of different types of glomerulopathies are still poorly understood. Our glomerulus functional genomics project aims at providing new information into the biology and pathology of the renal glomerulus.
Together with Christer Betsholtz, the group carries out an extensive project on the functional genomics of the renal glomerulus and its diseases. The entire mouse glomerulus transcriptome has been characterized, and over 300 novel transcripts and proteins highly specific for the glomerulus have been identified. To study the functions of these proteins, gene knockouts are being made in mice and knockdowns are being done on a large scale in collaboration with Majumdars group. Antibodies have been made against the proteins in collaboration with Mathias Uhléns group at the Royal Institute of Technology in Stockholm. In parallel, the proteome and its changes are studied in renal disease processes in mice. These studies are likely to lead to extensive new knowledge on the kidney filter system and its diseases, and they can form a firm basis for the development on diagnostics and drug development.
Selected publications
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Mol. Cell 1998 Mar;1(4):575-82
Nephrin is specifically located at the slit diaphragm of glomerular podocytes.
Proc. Natl. Acad. Sci. U.S.A. 1999 Jul;96(14):7962-7
Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene.
J. Am. Soc. Nephrol. 2000 Jun;11(6):991-1001
Role of nephrin in cell junction formation in human nephrogenesis.
Am. J. Pathol. 2000 Dec;157(6):1905-16
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.
Hum. Mol. Genet. 2001 Jan;10(1):1-8
Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
N. Engl. J. Med. 2003 Jun;348(25):2543-56
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure.
J. Intern. Med. 2003 Sep;254(3):216-24
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.
J. Clin. Invest. 2004 Nov;114(10):1475-83
How does the kidney filter plasma?
Physiology (Bethesda) 2005 Apr;20():96-101
Large-scale identification of genes implicated in kidney glomerulus development and function.
EMBO J. 2006 Mar;25(5):1160-74
Thin basement membrane nephropathy.
J. Am. Soc. Nephrol. 2006 Mar;17(3):813-22
Hereditary proteinuria syndromes and mechanisms of proteinuria.
N. Engl. J. Med. 2006 Mar;354(13):1387-401
Nck links nephrin to actin in kidney podocytes.
Cell 2006 Apr;125(2):221-4
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J. Am. Soc. Nephrol. 2007 Mar;18(3):689-97
Nephrin--a unique structural and signaling protein of the kidney filter.
Trends Mol Med 2007 Sep;13(9):396-403
Matrix metalloproteinases and Cancer
Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the extracellular matrix. Of those enzymes, MMP-2 and MMP-9, also called type IV collagenases or gelatinases, are related enzymes that break down type IV collagen. Our group first identified and purified MMP-2 and has for long studied different aspects of both MMP-2 and MMP-9. We recently succeeded in determining the first full structure of a pro-MMP (pro-MMP-2) and its free inhibitor TIMP-2, and have also determined the structure of a pro-MMP-2/TIMP-2 complex. The crystal structures can be used for development of novel specific enzyme inhibitors. The group also carries out studies on the regulation of MMP genes, and has inactivated the gene for the membrane bound MT1-MMP to study its normal role and involvement in diseases. Functions of some MMPs are studied in zebrafish.
Selected publications
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.
J. Mol. Biol. 1998 Dec;284(4):1133-40
Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.
Science 1999 Jun;284(5420):1667-70
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.
Proc. Natl. Acad. Sci. U.S.A. 2000 Apr;97(8):4052-7
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.
Proc. Natl. Acad. Sci. U.S.A. 2002 May;99(11):7414-9
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
Nat. Genet. 2002 May;31(1):94-9
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.
Cancer Res. 2004 Jun;64(12):4059-63
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.
Cancer Res. 2004 Jul;64(14):4699-702
Genomic instability in laminopathy-based premature aging.
Nat. Med. 2005 Jul;11(7):780-5
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
Nature 2005 Sep;437(7058):564-8
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis.
J. Biol. Chem. 2005 Jan;280(2):1292-8
Macrophage MARCO receptor
A novel MAcrophage Receptor with COllagenous structure (MARCO) was identified by the group using molecular cloning. This receptor was shown to bind bacteria and LPS, but not yeast. MARCO is normally expressed in certain macrophages of the spleen and lymph nodes, but is strongly upregulated upon systemic bacterial infections. MARCO and its involvement in host defense is extensively being studied from a number of angles, including cellular biology, knockout mice and gene regulation. We have also cloned and are functionally characterizing a novel scavenger receptor (SCARA5).
Selected publications
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.
Cell 1995 Feb;80(4):603-9
Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region.
J. Biol. Chem. 1998 Feb;273(8):4530-8
Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo.
J. Immunol. 1999 Jan;162(2):939-47
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor.
Genomics 1999 May;58(1):82-9
Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes.
J. Biol. Chem. 1999 Apr;274(16):10975-82
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles.
J. Exp. Med. 1999 May;189(9):1497-506
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO.
Biochem. Biophys. Res. Commun. 2002 Feb;290(5):1462-9
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.
J. Exp. Med. 2004 Jul;200(2):267-72
Characterization of recombinant soluble macrophage scavenger receptor MARCO.
J. Biol. Chem. 2002 Sep;277(36):33378-85
Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A.
J. Immunol. 2005 Dec;175(12):8173-80
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis.
J. Pathol. 2006 Mar;208(4):574-89
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO.
J. Biol. Chem. 2006 May;281(18):12767-75
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II.
J. Clin. Invest. 2007 Mar;117(3):757-64
Research group
|Ann-Sofie Nilsson
|Biomedical scientist
|Anna Domogatskaya
|Senior researcher
|Anne-May Österholm
|Senior researcher
|Jing Guo
|Research assistant on study grant
|Juha Ojala
|Kan Katayama
|Karl Tryggvason


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Make digital projects seem hand-made
Lisa Hassell finds out why it's become so fashionable to bring a handcrafted dimension to digital artwork
Lisa Hassell finds out why it's become so fashionable to bring a handcrafted dimension to digital artwork
Whether you're an artist who's never touched 3D, or an accomplished modeller wanting to spice up your renders, there's a lot to learn about how best to bring 3D suites, Photoshop and Illustrator together. Michael Burns finds out how the experts do it
Why are more and more creatives devoting their energies to good causes? Lisa Hassell investigates how your art and designs can make the world a better place
Neil Bennett talks to the artist and director about his cherished sideline -- his band
The trends, techniques and technologies at the cutting edge of graphic design – and how you can use them to produce your best work
A guided tour of the artists, exhibitions, workshops and entertainment of Berlin's annual character design and art festival
Angie Taylor reveals must-know techniques for every type of animation, drawn from the genre's 150-year history
Once the preserve of cartoon violence and crass misogyny, Michael Burns discovers how today's rock album and poster art has become hip again
Black-and-white art has its own unique impact as well as challenges, as Eva Peaty discovers


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Time Warner to meet with state Senate president over Journal Broadcast
Time Warner Cable has requested a meeting with state Senate President Mike Ellis (R-Neenah) in response to his request that cable customers receive rebates in the blackout of Journal Broadcast Group stations.
Ellis and a Time Warner representative will meet this afternoon, according to an Ellis aide.
In his letter to Time Warner, Ellis wrote: "It is clear your customers are no longer receiving the service they are paying for." »Read Full Blog Post(17)
State Senate president asks Time Warner to lower bills in WTMJ blackout
Wisconsin Senate President Mike Ellis (R-Neenah) has sent a letter to Time Warner Cable asking that it lower the bills of customers affected by the blackout of three stations in the retransmission dispute with Journal Broadcast Group.
"My intention is not to take sides but rather to look out for my constituents in this dispute," Ellis wrote. "It is clear your customers are no longer receiving the service they are paying for" and he urges Time Warner to "reduce their bills appropriately." He notes that Green Bay Packers preseason games are fast approaching and could be blacked out because of the dispute.
Fans that are Time Warner customers "should not be held hostage and punished because of a contract dispute." »Read Full Blog Post(96)


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P.S. A paltry 4000 shares! LOL
Ask him how low he thinks VRX goes this week and report back to us. TIA
CEO did not foresee world financial markets thrown into turmoil by Brexit when he bought. This is dropping so fast, so much more than the market. Shows some big players think something about the financial engineering behind VRX is particularly vulnerable to market shock.
What is going on? Why down so much more than the market?
Every time I go to look at options on any particular instrument, it says "system not working."
Completely unacceptable!
Don't tell me "zero."
Lot's of shorts will be taking profits.
I really doubt that Ackman is doing anything with the stock or with options. He's on the board as a Pershing representative. Isn't his trading now limited to narrow windows when insiders get their GC clear to buy or sell?
Don't see any news of consequence.
Does somebody know something we don't?
Any theories?
Is it too late to lean into this one?
Shareholders are watching you.
Is this sustainable?
Be wary folks.
Or has the slide barely begun?
"Let's put some lipstick on this pig."
"Time to restart this #$%$."
Remember those days?
They knew this disastrous news WEEKS ago.
Their lack of candor is a disgrace.