text:
Butts County was created in 1825 from portions of Henry and Monroe Counties. The name was taken from Captain Samuel Butts, a member of the Georgia Militia who was killed in the battle against the Creek Indians during the War of 1812. The town of Jackson was in honor of Andrew Jackson, a Georgia Hero, whose campaigns against the Creeks was memorable to Georgians; and also for his victory over British forces at the Battle of New Orleans. Researchers should search Henry County Records; particularly the deeds where many Butts residents are found.
Genealogy Records available to Members of Georgia Pioneers
Images of Last Wills and Testaments 1821 to 1841
- Butts County Wills 1821 to 1841 (abstracts)
Names of Testators: Atkinson, Arthur, Barkley, John, Barron, John, Blessell, Elisha, Blessell, Elisha, continued, Flewellen, Louiza, Heard, Stephen, Holly, Jacob, Knight, Walter, Lawson, Adam, Lindsey, Samuel, Malone, John, Messer, Isabel, Patrick, John, Reynolds, Thomas, Rhodes, William, Smith, John, Spear, orphans, Spears, Joseph, Stark, Samuel, Taylor, George, Taylor, John, Taylor, Joseph, Waldrip, Abraham, Walker, James, Wooten, James
Images of Wills and Estates 1845 to 1855
Names of Testators: Allison, William, Andrews, John, Atkinson, Cornelius, Berry, David, Dillon, Henry , Fielder, Joseph , Grier, Robert, Harrison, Benjamin, Lee, Harvey , Lofton, John, McGuire, Abin , Newton, Olive, Preston, John , Still, Bartholomew
Images of Wills and Estates 1849 to 1857
Names of Testators: Andrews, John, Atkinson, Cornelius, Allison, William, Bailey, Charles, Bankston, Olive, Camp, James, Cargile, John, Conger, Eli, Curry, Harriet, Dillion, Henry, Douglas, Robert, Douglas, Sarah, Fielder, Joseph, Gray, James, Greer, James, Hammond, W. J., Harrison, Elizabeth, Humber, Robert, James, John, Jarrell, William, Jinks, Joseph, King (minors), Lacy, Thomas, Lofton, John, McClure, James, McCord, Sarah, McCUne, Cornelius, McCune, James, McDaniel, John, McGuire, Abiah, Meridith, Elizabeth, Moore, Willis, Newton, Oliver, Nolen, Richard, Redman, William, Reeves, Green, Slaton, Mandane, Smith, David, Spencer, Thomas, Staton, H. P., Slaton, Samuel, White, Robert, Woodward, Aaron
Indexes to Probate Records
- Will Book A (1850 to 1896)
- Will Book B (1897 to 1948)
- Wills, Appraisements, Sales, Annual Returns 1826 to 1841.
- Appraisements, Sales, Annual Returns 1836-1845
- Wills and Annual Returns 1845 to 1851
- Wills, Appraisements, Annual Returns 1849 to 1857.
- Annual Returns and Vouchers 1852 to 1855
- Sales and Appraisements 1852 to 1874.
- Annual Returns and Vouchers 1864 to 1888
- Annual Returns and Vouchers 1889 to 1901
- Annual Returns and Vouchers 1896 to 1901
- 1827 to 1870
- General Index 1876 to 1896
Finding Old Church Records
By Jeannette Holland Austin
The early churches were the foundation of religious and social life in America, especially in rural developing areas. Elder B. M. Camp of Dallas, Georgia baptized his members under a waterfall on old High Shoals Road. The grave yard was nearby and a little one-room church building. This is typical. So what kind of records does the researcher expect to find in such a setting? Minutes, membership lists, baptisms, births, deaths and excommunications. Camp preached at High Shoals Primitive Baptist Church for more than 40 years and like so many other rural churches when he died the records disappeared. That does not necessarily mean that the old records do not exist today. While out in the field we have to ask local people for such things and follow the clues where they send us. It may not be as good as a church record, however, is the cemetery itself because it provides specific dates. Too, the layout of the plots is revealing. Families frequently shared the same plot of land, or were buried nearby. Sometimes it is easy to find unmarked graves within the same plot or to notice a depression in the soil. Look for broken tombstones. Slate was a popular medium which breaks easily and is sometimes found under the dirt within the grave plot. I always tour the surrounding area to see if any stones were taken somewhere else, like into the woods. The landscape was not as we see it. Some of the oldest graveyards were thoroughly vandalized. An example of this is colonial cemeteries where unpopular clerics or British subjects lay. All in all very few church records survived and are published. Ministers kept records of performed marriages but did not always take them to the county court house to be recorded there. That is why there is such a gap in the first marriage records. Sometimes marriage dates are recorded on tombstones or obelisks such as those found in Oakland Cemetery in Atlanta. However, the alternate source is the family bible.
Wilson Chapel in Jackson, Georgia.
See how Easy it is to read old Wills online Members also get to print/download image


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text:
Letter To My Teenage Self
Ray Leeper
If you're a convention kid, surely you know Ray Leeper. As executive director of NUVO Dance Convention and co-director of … More »
Antonio Douthit-Boyd
Alvin Ailey's Antonio Douthit-Boyd is the epitome of power and grace in perfect harmony. Yet it's his passion that captivates … More »
Sarah Lamb
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Michelle Dorrance
Tap star Michelle Dorrance has charmed audiences all over the world with her big smile and lightning-fast feet. The North … More »
Victoria Jaiani
It's not just luxurious extensions and delicate port de bras that make the Joffrey Ballet's Victoria Jaiani such a mesmerizing … More »
Joey Dowling
Whether you're a convention hopper, Broadway guru, devoted watcher of dance movies and TV shows or fan of the must-have … More »


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Inches were all that were separating Anderson County from tying Madison Southern Friday night as the teams battled for the Class 5A, District 6 high school football championship.
The Bearcats had driven inside Madison Southern's one-yard line with just under seven minutes to play. They had one more chance on fourth-and-goal.
For a lesson in the craziness of high school football, one just has to look at what is going on with Anderson County as the Bearcats tune up for the state playoffs Friday night.
Anderson travels to Shelbyville, where the Bearcats will be taking on Collins in the regular season finale. The kickoff is set for 7:30 p.m.
I thought I had seen or heard of everything in more than three decades of writing about high school sports.
I'd seen things I wish I hadn't such as a parent and coach in each other's face after a game. I'd seen coach and player so animated after a game that, even though the incident did not involve a team I was covering at the time, I pulled out my camera in case something did explode.
Thankfully, it didn't.
The day the Anderson County High School marching band has been pointing to throughout the fall is almost here.
The Marching Bearcats will be performing in the state Class AAAA semifinal round at South Oldham High School Saturday, Oct. 29, at 2:30 p.m. If Anderson is one of the top four bands in the semifinal round, it will move on to the state finals Saturday night. The time of the evening performance will be announced Saturday.
Louisville Newburg handed the Anderson County Middle School football team its first loss of the season, 24-0, in the State quarterfinals Saturday in Louisville. The Mustangs saw their season end at 12-1.
SHELBYVILLE -- The tears were real. They were more profuse than those shed around Anderson County boys' soccer had been in recent years.
They were in keeping with the almost-universal athletic truism that the hurt runs deeper when the stakes are higher. And make no mistake, the stakes were high for the Bearcats last Tuesday.
And the Bearcats believed they were capable of pulling off the unexpected in the Eighth Region semifinal round at Collins High School.
South Oldham showed why it has long been one of the programs by which all other Kentucky girls' high school soccer teams are measured when the Lady Dragons ousted Anderson County in the Eighth Region Tournament semifinal round last Tuesday at the Walton-Verona Sports Complex.
While the final score read South Oldham 5, Anderson County 0, things were decided in the first 15 minutes when the Lady Dragons scored a pair of quick goals and never looked back.
South Oldham eventually fell in the regional final, losing to Simon Kenton, 2-1.
Four Anderson County High School soccer players were named to the Eighth Region All-Tournament teams by the region's coaches last week.
Lady Bearcats Evan Kays and Taylor Harley were announced as members of the girls' all-tournament team after the regional championship game last Friday at Walton-Verona High School.
Bearcats Dalton Wells, a senior midfielder, and junior Shjon Ripy were named to the boys' all-tournament team following the regional championship game last Thursday at Martha Layne Collins High School.
Visiting Shelby County made the plays at the end of each set to defeat Anderson County in the opening round of the 30th District Tournament Monday night.
Shelby made the plays in the final points of each set to claim a 25-23, 25-20, 25-23 win over a depleted Lady Bearcat team. In the days leading up to the tournament, Anderson's seniors left the team, forcing the Lady Bearcats to put more of a load on younger players.
Anderson finished the season at 11-19.
Copyright © 2016
The Anderson News is your source for local news, sports, events, and information in Lawrenceburg, KY and the surrounding area.


text:
Yale Review Of Law And Social Action
A selection of articles related to yale review of law and social action.
Original articles from our library related to the Yale Review Of Law And Social Action. See Table of Contents for further available material (downloadable resources) on Yale Review Of Law And Social Action.
- Our Pagan Village: The Importance and Persuit of Honor
- Candlelight flickers over the Beltaine revels. Food is laid out in the circle for the feast. Only one rule – no one can feed themselves. Each is dependent on friends and loved ones for sustenance, joy and delight. After an hour of laughter and revels and way...
Paganism & Wicca >> Daily Life
- What is hypnotic trance? Does it provide unusual physical or mental capacities?
- 2.1 'Trance;' descriptive or misleading? Most of the classical notions of hypnosis have long held that hypnosis was special in some way from other types of interpersonal communication and that an induction (preparatory process considered by some to be...
Parapsychology >> Hypnosis
- The Religious Experience: A Wiccan Viewpoint
- What is religion? Religion is a set of beliefs which allow us to understand and categorize our world and our place in it. A set of beliefs which define our culture, our expectations, our views of people and behaviors we expect. I have found several different...
Religion & Philosophy >> Religions
- Survivalists' Guide for the New Millennium: Chapter 7
- MAKING FRIENDS WITH NATURE AND NATURAL LAW The fall of human society has not occurred overnight. It has taken many centuries, many millennia in fact, for the Divine potentials and inherent genius of the human being to degrade into the modern...
Philosophy >> Survivalists Guide for the New Millennium
- Pagan Mythology
- Is the traditional story presented as an historical event that serves to illustrate part of the world view of a people or explain a practice, belief, or natural phenomenon. The mythological beliefs a culture shares gives shape to its actions and choices....
Paganism & Wicca >> Holidays
- Survivalists' Guide for the New Millennium: Chapter 6
- AS THE WORM TURNS Health and well being are part of the natural birthright of the human being. With all of its organs intact, the right diet, exercise and mental focus, a human body can overcome any disease. Even so, the effects of living in this...
Philosophy >> Survivalists Guide for the New Millennium
Yale Review Of Law And Social Action is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Yale Review Of Law And Social Action books and related discussion.
Suggested News Resources
- Oberlin releases statements that seemingly contradict earlier statements
- Despite criticism that it was being soft on anti-Semitism, Oberlin College doubled down last month on its position that a professor's remarks on social media were protected speech.
- Solving the Mystery of the Schools
- The law mandated that every child in every school would take standardized tests in reading and math from grades three through eight and would achieve "proficiency" by the year 2014. No excuses. Even children who could not read English and children with ...
- Hillhouse high school academy system under scrutiny
- After indulging in stuffed clams, salmon and salads prepared by Hillhouse High School culinary students Monday afternoon, four New Haven alders met with roughly 30 students, teachers and school board members to informally review the school's ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Yale Review Of Law And Social Action Topics
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text:
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I like to read when not working or hanging out with friends. Sci-Fi tends to be the genre I read the most but Detective and Adventure novels are moving up the list. If you know who James Rollins is then you know the type of novels.
In my spare spare time, I like to play video games and go to the movies. I'm usually up for going to one and love to have company to go with me. My favorite thing is to go to 2 movies back to back so I feel I didn't waste money on snacks or go to Westwood.
I am outdoorsy, a book worm, and gamer
Oh apparently OKC has a dating profile:
And for those that care, depending on what I am doing in my life, I'm either INTJ or ENTJ.
Music: currently favs are AFI, 30 Seconds to Mars, My Chemical Romance, The Used and Mika but I'm open to pretty much everything except country and most rap.
Almost everything but seafood is something to try. I usually will at least try it but if I don't like it after the first taste I won't finish it. Exceptions being I try not to eat things that might have been pets in my mind: horses, cats and dogs definitely fall in this category and probably most of the meat my sis has on her farm. Lol
Great friends who are there no matter what the time
A job (so I can feed my dog and cat, have money to hang out with my friends, buy books and rent movies)
Perpetual hope.
I guess that's technically 7 but hey life's good. (And who says I can only pick 6! Bet you read all the way to the end anyways)
Oh and if you are contacting me with sex only type messages, I will just block you. Please don't be stupid.


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CityLine Internship
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"CityLine" is Channel 5's award-winning urban news and feature magazine program. For a half hour every Sunday at noon, "CityLine" explores an array of compelling subjects at length. The program focuses on the issues, concerns, and news affecting the Commonwealth's communities of color. The topics can range from social justice inequities to ethnic restaurants and everything in between. CityLine is searching for intelligent and motivated students in the Boston area who are interested in spending a semester with CityLine. Duties include but are not limited to:
- Researching story ideas
- Pre-screening and booking guests
- Assisting with field productions
- Learning to write program promotions and in studio interview questions
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- Academic Credit Required
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- Aptitude for deadlines and working in a fast paced environment
All interns come away from CityLine with something concrete: a show to place on their resume reel to use in a job hunt!
Professional business work attire is expected to be worn at all times.
Copyright 2007 by TheBostonChannel.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
I Want to Make You Safe
Amy King
December 2011 • 87 pp. • $15.00
Cover art by Deborah Grant
"'Rarely have the nude and the cooked been so neatly joined' as in Amy King's I Want to Make You Safe. If 'us,' 'herons,' and 'dust' rhyme, then these poems rhyme. If that makes you feel safe, it shouldn't. Amy King's poems are exuberant, strange, and a bit grotesque. They're spring-loaded and ready for trouble. Categories collapse. These are the new 'thunderstorms with Barbie roots.'"
— Rae Armantrout
"Vulnerability, fragility, and anxiety are all flushed out into the open here and addressed with such strong sound and rhythm that we recognize a resilient, defiant strength within them. King puts relentless pressure on forces seemingly beyond our reach and, in bringing them closer, exposes their own vulnerable centers. This is a poetry equally committed to language as a tool with social obligations and language as an art material obligated to reveal its own beauty. King's language does both magnificently."
— Cole Swensen
"Amy King's poems seem to encompass all that we think of as the "natural" world, i.e. sex, sun, love, rotting, hatching, dreaming, especially in the wonderful long poem 'This Opera of Peace.' She brings these abstractions to brilliant, jagged life, emerging into rather than out of the busyness of living: 'Let the walls bear up the angle of the floor,/Let the mice be tragic for all that is caged,/Let time's contagion mar us/until spoken people lie as particles of wind.'"
— John Ashbery
"I love Amy King's smile in photos of Amy King, Amy King's exuberance and looping, bashing panache (flamboyant manner, reckless courage) in the poems of Amy King, I'm going to say Amy King every chance I get in this blurb to make you think "I gotta read me some Amy King," especially if you're 'looking for anything/that will pull the cork, boil the blood/of displeasure,' as only the poems of Amy King can in the world in which Amy King is King (and Queen)."
— Bob Hicok
"The first poem I read by Amy King was 'MEN BY THE LIPS OF WOMEN' and it struck me with a force I had previously felt on encountering masterworks by Lorca and Dylan Thomas. I won't live long enough to see if her poetry will continue to equal the magnificence of theirs, but the fact that she achieved it once (at least) proves to me it could."
— Bill Knott


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(NEW YORK, NY) -- OBJECTify! September, 13th, NYC - OBJECTify the Book! You can burn it, you might spurn it - and that page right there dares you to turn it... You can look inside, break the spine, preserve a keepsake for all time. Throw it, Bestow it, and so help you, god, don't blow it! The Book!
Co-conspirators and New York party promoters, the Baroness, Xris SMack!, Irene Kaoru and Editrix Abby bring a resurgence of stimulating nightlife with OBJECTify! An ''open source'' format, with monthly guest producers, bringing fresh concepts. This month the legendary Chi Chi Valente curates and Daniel Bergner author of the Other Side of Desire will do a short reading...
The objective - to unite the many tribes: twisted, gay, straight and bi; male, female, trans; young, old; costumers, anachronists and crossdressers; the kinky and the queer; the polyamorous, swingers; sadists, masochists, fetishists; fairies, fashionistas; freaks, geeks, hippies; hipsters, wishters and wannabes. While, providing an environment where even the most ''vanilla'' of adventurers can feel safe to explore, experiment and experience.
Embracing the Dadaist anti-aesthetic, each month OBJECTify will obsess about one particular Object. This months Object the book, think: The bible or going back to school and dress accordingly. Influenced by Burning Man and its ''no spectators'' ethos, OBJECTify encourages guests to partYcipate, so each attendee contributes to the evening's collective outcome.
To encourage guests there is reduced admission for the uniquely dressed to reflect, reject or otherwise demonstrate a grasp of the party theme, and a $100 cash prize for the most inspired! Downstairs is the fully equipped ''Rubber Room'' presided over by the Baroness with dancing and play.
Always the second Sunday of each month, OBJECTify will uplift or destroy a particular Object. So come thematically and dramatically attired and be prepared to partYcipate.
Held at the Delancey Lounge, 168 Delancey Street (between Clinton & Attorney). New York City. Doors at 9pm (till 4am). Admission is Free for Artists who bring 2D/3D art, offer a performance or otherwise compete for the Cash Prize for the most inspired interpretation of the chosen Object. $10 for those who dress!. $20 for everyone else.
I Remain,
The Baroness
530 B East 13th Street New York City, NY 10009
Monday-Saturday 2-7 Thursday 2-9
Adult Biz Halloween Party
Bukkake Participants Needed
Sugarcookie Earns Nom
Hookers for Hillary
Tarts for Trump
Color Blind ~ Reviewer Rated
Lamar Odom's Prostitute Talks
Kagney Linn Karter in Minneapolis
Angelina Castro Anniversary
Elizabeth Starr May Lose Breasts
Lolly Ink Self Booking
Sophie Dee in Miami
NightMoves Sponsors
Marica Hase Birthday Party
PSK Celebrates 13
Jayden Lee at Crazy Horse
Centerfold Features
Alison Tyler at HQNYC
ED Awards Winners
Clubs & Appearances Section Index
Sabrina Deep Bukkake Tour Update
Layton Benton to Exxxotica
Vivid Hosts Texxxas Parties
Dani Daniels in Houston
GFE at Sheri's Ranch
Jenevieve Hexxx at Trixie's
Carnal Comedy at Sapphires
ED Expo Returns to NO
Kendra Sunderland at Sapphire NYC
Gentlemen's Club Live Feed
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text:
This has been a great day! New Music from J. Cole & The Weeknd and now we have the official music video from Frank Ocean! What more could we ask for? A greatly shot video which captures the use of the pain numbing drug Novacane, directed by Nabil who is also a photographer. Nostalgia, Ultra will be re-released by Def Jam in the near future – keep an eye out! Stay tuned!
Submit your comment


text:
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text: One of the great secrets of the Cape is to avoid the often crowded ocean beaches and find a place that has access a freshwater lake. The Alexander Hamilton House is situated on Ashumet Pond near Mashpee Commons – far off the main tourii grid. This bed and breakfast has its own private beach and a flotilla of small boats... More


text:
Samsung Crescent Racing's John Hopkins (Suz) made a splash in his wild card debut for his British Superbike team by setting the fastest time in morning free practice at the ninth round of the World Superbike Championship at Silverstone. The Californian backed it up by finishing fifth in the afternoon qualifying.In his first season in BSB, Hopkins is challenging for the championship lead; currently he sits second to Shane Byrne. But Silverstone isn't a track he's raced on before – the series doesn't visit the circuit until later in the season – which means that Hopkins didn't have home field advantage.In the morning Hopkins was fastest in front of Aprilia Alitalia's Leon Camier and Czech rider Jakub Smrz on the Team Effenbert-Liberty Racing Ducati. BMW Motorrad's James Toseland finished the morning a surprising fourth after returning from an extended injury lay-off.
Championship leader Carlos Checa (Althea Racing Ducati) was fifth as a prelude to qualifying. In the afternoon the Spaniard was back on pace to take the overnight pole with a lap of 2:05.477 mins. Having taken four poles this season, that wasn't a surprise. What was a surprise was that the second fastest Friday qualifier was Frenchman Maxime Berger. The Supersonic Racing Ducati rider finished .393 secs. behind Checa in what would be by far his best qualifying position of the season. So far, he hasn't qualified higher up the grid in Superpole than 12th.Berger was the best of the rest in a pack that was tightly bunched; second to 17th were covered by less than a second. Brit Tom Sykes used his home track knowledge to take the third fastest time in front of Camier, and Hopkins was a provisional fifth fastest.Team Suzuki Alstare's Michel Fabrizio was sixth followed by Smrz, Yamaha's Eugene Laverty, and reigning world champion Max Biaggi (Aprilia Alitalia). Leon Haslam was the first BMW in tenth places.Superbike Qualifying: 1. Carlos Checa (Ducati) 2:05.477
2. Maxime Berger (Ducati) 2:05.870
3. Tom Sykes (Kawasaki) 2:05.899
4. Leon Camier (Aprilia) 2:05.937
5. John Hopkins (Suzuki) 2:05.974
6. Michel Fabrizio (Suzuki) 2:06.023
7. Jakub Smrz (Ducati) 2:06.029
8. Eugene Laverty (Yamaha) 2:06.037
9. Max Biaggi (Aprilia) 2:06.044
10. Leon Haslam (BMW) 2:06.116


text:
Hearing aids in Pen Argyl, PA
We found 17 hearing clinics with 70 reviews within 43.4 miles of Pen Argyl, PA.
Featured hearing professionals near you
Total Hearing Care - Phillipsburg
Call: (908) 760-4073
Scott Rawicz, M.A., CCC-A
Audiologist Scott Rawicz has many years experience in Otolaryngology offices and hospital settings. (read more)
Center for Audiology Services
Call: (610) 628-3006
Janet Westlund, Au.D.
Janet has over 25 years of experience. She earned her B.S. in Communication Disorders from the (read more)
St. Luke's North Audiology
Call: (610) 628-3037
Sarah Jones, Au.D., CCC-A
Sarah joined St Luke's in 2009 and earned her Master's degree in Audiology from Ohio (read more)
G. T. Kleckner Audiology
Call: (610) 628-4163
Glen Kleckner, M.Ed.
Each patient I work with has the opportunity to experience the best in hearing technology. I believe (read more)
Sussex Audiology Services & Hearing Aid Center, LLC
Call: (973) 459-4523
Elizabeth Chiusano, M.Ed., CCC-A
Beth is the owner of Sussex Audiology and has over 30 years of experience. She earned her (read more)
The Doctors' Hearing Center, LLC at Hunterdon Otolaryngology & Allergy Associates
Call: (888) 429-0286
Diana Anderson, Au.D.
Dr. Diana Anderson completed her Doctor of Audiology degree in 2010 from the George S. Osborne (read more)
Audiology and Hearing Aid Service
Call: (610) 643-4694
Virginia Grim, AuD
Dr. Virginia Grim is the licensed audiologist serving patients at Audiology and Hearing Aid Services (read more)
Additional professionals near you
Warren Hospital Audiology
Call: (908) 859-6758
View Clinic Details
Audiology Services
Call: (610) 628-4919
View Clinic Details
Bethlehem Audiology Associates
Call: (610) 628-0652
View Clinic Details
Eastern Audiologic Rehabilitation
Call: (610) 643-4386
View Clinic Details
Total Hearing Care - Hackettstown
Call: (908) 645-0750
View Clinic Details
East Penn Hearing Center
Call: (610) 421-4626
View Clinic Details
Total Hearing Care - Newton
Call: (973) 862-4706
View Clinic Details
Audiopedics LLC
Call: (908) 479-1341
View Clinic Details
Hunterdon Medical Center Speech and …
Call: (908) 751-1746
View Clinic Details
Geisinger Medical Group - Wyoming Va…
Call: (570) 301-6917
View Clinic Details


text:
realmagick.com The shrine of knowledge.
Big Finish Productions 2000ad
A selection of articles related to big finish productions 2000ad.
Original articles from our library related to the Big Finish Productions 2000ad. See Table of Contents for further available material (downloadable resources) on Big Finish Productions 2000ad.
- A Ghostly House in Kansas
- Inteview with SUZANNE and JEFFERY DIEHL and their children JOURDANNE DIEHL, age 4, and PAUL ROATH age 13. June, 1999. Interview by SuzAnne's aunt Linda Kangas and Gene Kangas, Concord OHIO. The subject concerns spiritual occurrences at an early 20th century...
Ghosts >> Ghost Stories
- Everyday Air
- We breathe it in every day. It surrounds us, fills us, yet often we don't even notice it: Air. Of all the elements, Air is perhaps the most illusive. It can be the most difficult to describe, but can also be one of the most vibrant. Air brings us the light...
The Elements >> Air
- Stimulate Your Own Immune System
- Can you stimulate your own immune system? I work with people that are faced with life challenging illnesses such as cancer, AIDS, leukemia PNH, etc. It's very interesting how some people can fight these illnesses in spite of a bleak picture that the...
>> Body Mysteries
- Happiness is a decision
- Happiness is transpersonal divine joy and fulfillment in creating and connecting. It is the outbursting purity of the Universe. In happiness one is opening up to the fullest for life, her gifts, possibilities and challenges. This implies that happiness is not...
Mind >> Meditation
- Astrological Emphasis: Pisces, 2001
- General | Love | Work | Health Pisces: February, 21st - March, 20th. This article applies to Pisceans during 2001. General Pisces is the twelfth sign of the Zodiac, astrologically dominated by Jupiter and Neptune, exalted by the Moon and with Mercury in exile....
Astrology >> Pisces
- Lauràelle, the Ceremony & the Sword: An OBE Experience
- I have profoundly hesitated over the telling of this tale for many years. I have a lifetime of experiences like this to share, but some (like this one) may seem way over the top to some people, no matter how its written. This is simply because they lack any...
Astral Projection >> Out of Body Experiences
Big Finish Productions 2000ad is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Big Finish Productions 2000ad books and related discussion.
Suggested News Resources
- Victor Frankenstein dead on arrival at UK box office
- With a reported production budget of $40m (£26.7m), Victor Frankenstein looks as if it might be a costly disappointment for its stakeholders, including distributor Fox. The film has grossed only $5.
- Two New 'Deadpool' Trailers Arrive on Christmas Day (Video)
- 20th Century Fox and Marvel have released two new trailers for Ryan Reynolds' Deadpool on Christmas Day — one naughty, and one nice. After dropping hints about a new look at the upcoming R-rated X-Men spinoff during a spirited "12 Days of Deadpool" ...
- Jessica Jones recap, episodes 1-7: what do you make of Marvel's newest TV hero?
- Really? I basically feel the exact opposite - Tennant had me quite literally shuddering in the last episode I watched. I think he's brilliant.
- How DC Is Already Dominating Marvel In 2016
- Marvel has set the bar for the comic book movie adaptation, and now it's DC's job to try and clear it. What Marvel's cinematic universe has gone largely unchallenged to this point, 2016 is set to be the year that DC and Warner Bros.
- Future Shock! The Story of 2000AD review – classic comic in the frame
- 2000AD dabbled with darkness way before it became normal for a superhero's nemesis to be their neuroses. Spawned in the punk era, the crazy, violent, garish comic is best known for giving us Judge Dredd, the fascist future cop who was judge, jury and ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Big Finish Productions 2000ad Topics
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© 2000 - 2016 Realmagick.com, All Rights Reserved.


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text:
4 posts tagged with cia by Ignatius J. Reilly.
Displaying 1 through 4 of 4.
The 5pm Deadline is approaching,
The 5pm Deadline is approaching, but the White House doesn't care. The White House--expected to turn in all documents relevant to the Justice Department investigation of the Plame affair--has instead decided that a team of lawyers ought to spend two weeks determining which evidence can be used against their clients. Meanwhile, President Bush continues his two-month initiative to get to the bottom of the matter himself.
It's not censorship if it doesn't work
GOP Warns TV Stations Not to Air Ad Alleging Bush Mislead the Nation Over Iraq They claim that the ad itself is dishonest, and cite the obligation of broadcast outlets to be free of misleading information. "Such obligations must be taken seriously. This letter puts you on notice that the information contained in the above-cited advertisement is false and misleading; therefore, you are obligated to refrain from airing this advertisement." Despite the implicit threats, only one station has refused to run the ad, a Fox station.
Rumsfeld made his own intelligence
Rumsfeld's personal spy ring The defense secretary couldn't count on the CIA or the State Department to provide a pretext for war in Iraq. So he created a new agency that would tell him what he wanted to hear. Today, Salon also looks into the role played by John Bolton. Is investigative journalism now just relegated to the web? [you have to look at an ad, I believe]
The harder they come, the harder they fall
Tenet Had to be Pushed to Take Responsibility. George W. Bush may believe that the yellowcake controversy is over, but the underlings of the fall guy Tenet in the CIA are already starting to sing. The administration have gone out of the way to stress that they still trust the CIA, despite the brewing scandal. So maybe we should all pay attention to these leaks?
Page: 1


text:
Paterson Wants to Boost Clothing Taxes; Alvin Valley Relaunches Collection
Also, Marilyn Monroe photos fetch almost $150,000 at auction, and Jessica Stam has the flu.
• Governor David Paterson has proposed an additional 5 percent tax on luxury goods like jewelry and furs costing more than $20,000. He also wants to take away the tax exemption on shoes and clothes costing less than $110. Um, no thanks. [WWD]
• Alvin Valley is relaunching his Collection line with a show at New York Fashion Week. "I felt like people weren't spending extraordinary amounts of money on expensive dresses and furs, so I laid off of it for a while," he says. Things have changed? [WWD]
• Images of Marilyn Monroe shot by Bert Stern in 1962 for Vogue sold at auction for almost $150,000 yesterday. They're believed to be the last professional pictures taken of her before her death. [British Vogue]
• Model Jessica Stam missed her co-hosting duties at the Charity Water benefit on Monday because of the flu. [NYP]
• Emma Thompson: "If I buy anything, I lie about it, hide it or stain/chip it slightly and claim it was 75p in the Scope shop." [British Vogue]


text:
Hi Ubuntu Commumnity:
I have a nice HD TV that is in my living room.
It is no problem to bring an internet cable to the TV, but the TV is not iternet ready ... it does not have an internet jack! However, it has several HDMI slots, and
Also, I have a nice computer with Precice on it that runs MythTV. However, that computer is in my kitchen... far away from that TV.
I want to stream my MythTV recordings from the computer in my kitchen, over my home network, to the HDTV in my living room.
How do I do this?
Old Jimma from the Old Country


text:
Patent application title: VIRUCIDAL COMPOSITIONS AND USES
Stephen Spaulding Hickok (London, GB)
IPC8 Class: AA61K3334FI
USPC Class:
Class name: Inorganic active ingredient containing heavy metal or compound thereof copper
Publication date: 2009-12-10
Patent application number: 20090304813
Sign up to receive free email alerts when patent applications with chosen keywords are published SIGN UP
A composition for use in treating or preventing a respiratory virus which
comprises: (a) at least one water soluble zinc, copper, selenium and/or
manganese compound able in aqueous solution to dissociate into zinc,
copper selenium and/or manganese ions; (b) at least one water soluble
ammonium agent able in aqueous solution to dissociate into ammonium ions
(c) at least one acid, and (d) water.
1. A composition for use in treating or preventing a respiratory virus
which comprises(a) at least one water soluble zinc, copper, selenium
and/or manganese compound able in aqueous solution to dissociate into
zinc, copper selenium and/or manganese ions;(b) at least one water
soluble ammonium agent able in aqueous solution to dissociate into
ammonium ions(c) at least one acid, and(d) water.
2. A composition for use in treating or preventing a respiratory virus which essentially consist of:(a) at least one water soluble zinc, copper, selenium and/or manganese compound able in aqueous solution to dissociate into zinc, copper selenium and/or manganese ions;(b) at least one water soluble ammonium agent able in aqueous solution to dissociate into ammonium ions(c) at least one acid, and(d) water.
3. A composition for use in preparing a medication for use in treating or preventing a respiratory virus, which composition comprises:(a) at least one water soluble zinc, copper, selenium and/or manganese compound able in aqueous solution to dissociate into zinc, copper selenium and/or manganese ions;(b) at least one water soluble ammonium agent able in aqueous solution to dissociate into ammonium ions(c) at least one acid, and(d) water.
4. A composition for use in preparing a medicament for use in treating or preventing a respiratory virus, which composition essentially consists of(a) at least one water soluble zinc, copper, selenium and/or manganese compound able in aqueous solution to dissociate into zinc, copper selenium and/or manganese ions;(b) at least one water soluble ammonium agent able in aqueous solution to dissociate into ammonium ions(c) at least one acid, and(d) water.
5. A composition as claimed in any preceding claim having a pH of less than 4.
6. A composition as claimed in any preceding claim having an electrolytic potential in excess of 50 milivolts.
7. A composition as claimed in any preceding claim further including an excipient or diluent.
8. A composition as claimed in claim 7 in which the diluent comprises saline.
9. A composition as claimed in any preceding claim in the form of a virucidal gel.
10. A composition as claimed in any one of claims 1 to 8, in the form of a spray such as a spray adapted for nasal use.
11. A composition as claimed in any one of claims 1 to 8 in the form of a substrate impregnated with the composition.
12. A composition as claimed in any preceding claim, wherein the virus to be treated or prevented is an influenza virus.
13. A composition as claimed in claim 12 wherein the virus is of H1N1, H7N7, H9N2 or H5N1 strain.
14. A composition as claimed in any preceding claim, wherein the strain is H5N1 and associated with causing avian influenza.
15. A composition as claimed in any one of claims 1 to 11, wherein the virus to be treated or prevented is a respiratory virus responsible for causing common cold symptoms.
16. A composition according to any one of claims 1 to 11 in combination with another antiviral preparation.
17. A composition as claimed in claim 16 in which the other preparation is oseltamivir phosphate.
18. A composition as claimed in any preceding claim, wherein at least two different such metal-ion species are present.
19. A composition as claimed in claim 18 in which metallo-ions of zinc are present together with one or more of copper, selenium and manganese metallo ions.
20. A composition as claimed in any one of claims 9 to 19 in which the gel is based on aloe barbadensis.
21. A composition as claimed in claim 20 in which the gel comprises at least one thickener such as xanthan gum.
22. A composition as claimed in claim 21 in which at least one preservative is present.
23. A composition as claimed in any one of claims 9 or 20 to 22 in which the gel contains copper metallo ions.
24. A composition as claimed in claim 23 in which the amount of copper ions present in the gel is at the level of 100 to 500 ppm, preferably 150 to 450 ppm, more preferably 200 to 350 ppm.
[0001]This invention is concerned with virucidal compositions and their
use in preventing and/or treating a spectrum of viral species, but in
particular for preventing and/or treating viruses which cause human or
animal respiratory disease. The terms `treating` and `treatment` are used
herein to embrace killing of the virus or viral particulates or
controlling/preventing viral replication. More specifically, the
invention in all its aspects is concerned with compositions useful in the
treatment and/or prevention of the common cold and/or influenza and/or
pneumonia-causing viruses. Even more specifically, the invention in all
its aspects is concerned with compositions useful in the treatment and/or
prevention of influenza viral strains including for example influenza
virus of H1N1, H7N7, H9N2 or H5N1 strain, the latter responsible for
avian flu associated with a high mortality rate. Infection by H5N1 strain
of influenza virus, for example, is known adversely and seriously to
affect the lungs as described hereafter.
[0002]There is potential for avian flu (or other H5N1 viral strains) to spread beyond infected areas. Whilst indications were that viral transmission was restricted from infected bird to human, there are concerns in view of more recent limited evidence for human to human transmission through mutation of the virus into a form transmissible between animal species.
[0003]Since avian `flu` is associated with high mortality, in the event of mutation to a highly infective, inter-human transmissible form this raises the spectre of `pandemic` outcomes with substantial fatalities. Whilst it remains highly desirable to treat, and where possible prevent, respiratory viral infections, it is especially desirable to provide formulations effective to treat and/or prevent the more serious respiratory viral infections including the most serious of such infections arising from respiratory viral H5N1 strains.
[0004]Unlike bacterial infections, many of which can be treated with known conventional antibacterial drugs such as antibiotics, respiratory viral infections e.g. the common cold or influenza cannot be treated with antibiotics. In the majority of respiratory viral infections, most of the presently available antiviral drugs are ineffective, and the body's own immune defence system has to fight the viral infection. Whilst this is typically the case with the common cold and influenza, it is especially so with influenza virus H5N1 strains and with influenza viral strains H1N1 and H7N7.
[0005]There is, in the relevant medical literature, considerable knowledge as to the mode of action of H5N1 viral infection and the weakness of the body's natural immune defence system to combat the virus. There are, however, very limited treatments available. One antiviral drug which may offer prophylactic and/or post-infection treatment of avian flu is oseltamivir phosphate, marketed by Roche under the Trade Name TAMIFLU. However, supplies are limited; it is significantly expensive and has potential side effects. In addition, there are concerns that resistance to Tamiflu® might occur during a pandemic when large amounts of Tamiflu® are likely to be taken in the many different countries that have stockpiled the drug. Active metabolites of Tamiflu® are very stable and their accumulation in water sources may rapidly lead to influenza virus resistance.
[0006]Although vaccination is available against certain limited strains of influenza virus as a prophylactic measure, there is currently no marketed vaccine effective as a prophylactic measure against human infection by e.g. H5N1 strains of influenza virus. H5N1 viruses induce a pro-inflammatory `cytokine storm` to which they are highly resistant and which severely damages the lungs and compromises immune function for combating viral infection. These factors alone make H5N1 viral strains especially problematic to prevent or treat with most of the available antiviral drugs.
[0007]We have now surprisingly found that a specific narrow selection of mineral--or other metallic element containing compositions disclosed as a broad range of multi-functional products in our earlier patent publication WO 01/15554, and combinations thereof, are unexpectedly useful in the treatment of respiratory viral infections, including prophylactic treatments against infection by H5N1 viral strains. We have also surprisingly found that these selected compositions, and particular combinations of such metallo-ions, can be blended into novel gel and other carrier formulations and used in sprays or hand wipe substrates so as to provide for example the following embodiments of the present invention, namely: [0008](i) nasal sprays and gel barrier formulations useful as prophylactic treatment to assist in prevention of infection by respiratory virus, especially influenza virus of H5N1 strain; in preferred embodiments the viscosity is less than 4750 centipoise, such as less than 4500 centipoise, preferably less than 4000 centipoise, ideally less than 3000 centipoise, such as in the range of 1 to 2500 centipoise. [0009](ii) cleansing gels which exhibit powerful virucidal properties useful to control (i.e. to kill, render harmless or otherwise interfere with replication of) live virus or viral particles, and [0010](iii) hand wipe substrates, such as disposable wipes impregnated with the compositions, and optionally modified by thickening agents or stabilisers.
[0011]We also provide embodiments in suitable oral dosage form, for example, iv) oral dosage formulations based on liquid aqueous compositions. The aqueous compositions can have single or multiple metallo-ionic species selected from a particular range. The aqueous compositions may entirely consist of the active components or may essentially consist of the said active components. In other embodiments, the metallo-ionic compositions may include optional additives such as one or more excipients and/or diluents.
[0012]Accordingly, in one aspect the present invention provides for use in treating a respiratory virus a composition comprising: [0013](a) at least one water soluble zinc, copper, selenium and/or manganese compound able in aqueous solution to dissociate into zinc, copper, selenium and/or manganese ions; [0014](b) at least one water soluble ammonium agent able in aqueous solution to dissociate into ammonium ions [0015](c) at least one acid, and [0016](d) watersaid composition preferably having a pH of less than 4 and preferably an electrolytic potential in excess of 50 milivolts.
[0017]In another aspect the invention provides a composition as defined above for use in treating an influenza virus, such as influenza virus of H1N1, H7N7, H9N2 or H5N1 strain, preferably of H5N1 strain.
[0018]In yet another aspect the invention provides a composition as defined above for use in treating viruses responsible for causing common cold symptoms.
[0019]In a still further aspect, the present invention provides compositions as defined above for use in the preparation of a medicament for use in treating respiratory viruses such as influenza viruses, preferably influenza virus of H5N1 strain, alternatively common cold viruses or a pneumonia virus. 60% of common colds are caused by rhinoviruses. The rest occur due to infection by coronavirus, influenza viruses, parainfluenza virus, respiratory syncytial virus, adenovirus, and enterovirus. In addition, the bacteria Mycoplasma pneumoniae and Chlamydia pneumoniae may cause common cold symptoms.
[0020]The compositions defined above may further include one or more additives selected from vitamin B1, B, B5, B6, C, malic acid, a natural diuretic, melatonin and valerian. The composition may essentially or preferably entirely consist of the stated components. Most preferably the water is distilled water.
[0021]The compound of zinc, copper, selenium and/or manganese is preferably an inorganic salt thereof such as the phosphate, sulphate, nitrate or chloride.
[0022]The ammonium agent, capable of binding, complexing or otherwise sequestering the zinc, copper and/or selenium ions is conveniently an inorganic ammonium salt or ammonium hydroxide capable of dissociating in aqueous solution into ammonium ions. For example, one or more of the following may be present in the composition: ammonium hydroxide, sulphate, chloride, phosphate, nitrate, citrate and tartarate.
[0023]The at least one acid is conveniently selected from the following group: sulphuric, hydrochloric, nitric, phosphoric, citric and tartaric acids. The at least one acid can be for example concentrated sulphuric, hydrochloric, nitric or phosphoric acids.
[0024]The pH of the composition can be less than 4, such as 3.5 or less, 3 or less, 2.5 or less such as 2 or less such as in the range of 1 or less. The electrolytic potential can be for example, in excess of 100 mV, or in excess of 150 mV, or in excess of 200 mV, or in excess of 250 mV, or in excess of 300 mV or in excess of 340 mV such as in the range up to 400 mV.
[0025]The compositions encompassed by the present invention can be made as outlined in the `general procedure` section in our earlier patent publication and as exemplified therein, where the metallic or other mineral element in the table of examples therein is at least one of copper, zinc, selenium and manganese. When using compositions with more than one metallo-ionic species, copper and zinc may be present with or without selenium; Selenium and zinc may be used together, with or without copper. Copper and selenium may be present together, with or without zinc. All may be present with manganese or it may be used alone. A suitable manganese preparation can be made by extrapolating from the general procedure outlined above, using e.g. manganese sulphate, sulphuric acid and ammonium sulphate to arrive at a composition pH of 2 or less and a potential in excess of 250 milivolts.
[0026]The invention further provides antiviral compositions as defined above having antiviral activity against respiratory infections including seasonal influenza, H5N1 or avian influenza, acute coryza. Such compositions may include one or more conventional pharmaceutically acceptable carriers, diluents and/or or excipients, such as saline as a diluent.
[0027]In order to illustrate the present invention the following purely non-limiting examples, presented in our earlier patent publication WO 01/015554 were used to make suitable compositions. They were prepared according to the same general procedure outlined in our earlier said patent publication. In Table 1 below, the following examples according to the present invention correspond with the stated numbered prior examples thus.
TABLE-US-00001 TABLE 1 Example No. Example No. (present invention) (earlier publication) Ionic species present 1 1 Cu2+, (NH4).sup.+ 2 2 Cu2+, (NH4).sup.+ 3 3 Cu2+, (NH4).sup.+ 4 4 Cu2+, (NH4).sup.+ 5 11 Se2+, (NH4).sup.+ 6 12 Se2+, (NH4).sup.+ 7 15 Zn2+, (NH4).sup.+ 8 16 Zn2+, (NH4).sup.+ 9 17 Zn2+, (NH4).sup.+ 10 18 Zn2+, (NH4).sup.+ 11 18a Zn2+, (NH4).sup.+ 12 19 Cu2+, (NH4).sup.+ 13 20 Cu2+, (NH4).sup.+ 14 21 Cu2+, (NH4).sup.+ 15 22 Cu2+, (NH4).sup.+ 16 23 Zn2+, (NH4).sup.+ 17 24 Cu2+, (NH4).sup.+ 18 25 Cu2+, (NH4).sup.+ 19 26 Cu2+, (NH4).sup.+ 20 27 Cu2+, (NH4).sup.+ 21 29 Cu2+, (NH4).sup.+ 22 30 Cu2+, (NH4).sup.+ 23 31 Cu2+, (NH4).sup.+ 24 32 Cu2+, (NH4).sup.+ 25 33 Cu2+, (NH4).sup.+ 26 34 Cu2+, (NH4).sup.+ 27 35 Cu2+, (NH4).sup.+ 28 36 Cu2+, (NH4).sup.+ 29 37 Cu2+, (NH4).sup.+ 30 38 Cu2+, (NH4).sup.+ 31 43 Zn2+, (NH4).sup.+ 32 45 Zn2+, (NH4).sup.+
[0028]Compositions as defined and exemplified above may be used in at least 3 treatment regimes to combat respiratory, especially influenza and more particularly H5N1 influenza viruses. They may be used as a prophylactic treatment to block entry of the virus into the nasal mucous membranes [typically the most common site of entry] and/or to kill the virus or viral particulates. Such blockage may be effected by application of nasal gels or aqueous sprays, i.e. a pharmaceutically acceptable gel or spray carrier medium containing at least one composition as defined and/or exemplified above. The virus, where present, may also be controlled by such anti-infective gel formulations as hand cleansing gels, i.e. the composition can be formulated into a topically acceptable gel medium known per se, but providing by the admixture of two known entities a novel antiviral gel or spray formulation. Furthermore, hand wipe substrates such as disposable tissues may be impregnated or coated with the compositions optionally modified to improve adherence. It is preferred to use at least the copper containing compositions in nasal gels, cleaning gels and hand wipes as a means for blocking viral entry and/or killing or controlling the virus or viral particulates.
[0029]In order to demonstrate activity of the present compositions against respiratory viruses, some were prepared and tested against H5N1 influenza viruses in vitro and in vivo to show potential for managing avian flu. The anti-oxidant properties of selenium based compositions is indicative of direct potential for virucidal activity. Three principal embodiments are presented based on single zinc, copper and selenium based compositions, and a fourth embodiment directed to the use sequentially of the present manganese, zinc and selenium metallo-ion compositions namely:
1) Virucidal activity against human H5N1 virus in vitro murine studies (Zn, Cu & Se)2) Toxicology and dose ranging study in mice (Zn),3) Prophylactic activity in mice infected with a lethal H5N1 influenza virus (Zn), and4) Human case study where conventional influenza viral infection is attenuated by a combination therapy involving sequential internal administration of doses of manganese, zinc and selenium compositions.
Virucidal Activity Against Human H5N1 In Vitro
[0030]In the in vitro virucidal assay, the A/Vietnam/1203/04 (H5N1)×Ann Arbor/6/60 influenza virus was exposed to the copper metallo-ion compositions (equivalent to elemental copper at 3 ppm), the zinc metallo-ion compositions (equivalent to elemental zinc at 2 ppm) and the selenium metallo-ion compositions (equivalent to elemental selenium at 1 ppm) or to water (control) for 10 minutes at room temperature. The treated viruses were then assessed for infectivity using the standard MDCK cell assay.
[0031]The results in Table 2 below show that while the zinc and selenium compositions at their exceptionally low concentrations showed no significant direct antiviral effect, the copper compositions caused a >90% reduction in virus titre despite a similarly exceptionally low concentration.
TABLE-US-00002 TABLE 2 Concentration (ppm) Initial low dosages in Log 10 Reduction Sample view of acidity/pH in virus Titre Cu 3 1.75 +/- 0.00 ** Zn 2 0.25 +/- 0.35 Se 1 0.88 +/- 0.88 Water N/A 0.00 +/- 0.00 ** statistically different from water (p < 0.001)
[0032]These results suggest that a nasal gel containing at least 3 ppm (=3 μg/ml) of the ionically modified copper compositions could provide not only a barrier to viral entry into the upper respiratory tract but also may kill a significant percentage of the viral particles encountering the gel. Since influenza viruses can be picked up from infected surfaces and transferred to the nose and eyes where entry occurs, use of hand wipes or hand gels containing at least 3 ppm of the copper compositions as a prophylactic measure can be of substantial benefit for reducing or preventing infection especially during a pandemic.
TABLE-US-00003 TABLE 3 Effect of Oral Treatment with ZnAL42 on an Influenza A (H5N1) Virus Infection in Mice. Animals: Female 18-21 g BALB/c mice Virus: Influenza A/Duck/MN/1525/81 (H5N1) Drug diluent: Saline Treatment schedule: as described below Treatment route: p.o. Expt. duration: 21 days Tox Controls Mean Host Infected, Treated Mice Dosage Surv/ Weight Surv/ Mean Day to Mean Day 11 Treatment (mg/kg/day) Treatment Schedule Total Changea (g) Total Deathb ± SD SaO2 (% ± SD) ZnAL42 17.28 qd × 7 beg -48 h 3/3 -0.7 1/10 9.2 ± 3.0 75.3 ± 0.7 8.74 qd × 7 beg -48 h 3/3 1.1 3/10 8.4 ± 1.1 76.7 ± 2.8* 17.28 bid × 7 beg -48 h 3/3 2.7 8/10*** 7.0 ± 1.4 81.0 ± 3.5*** 8.74 bid × 7 beg -48 h 3/3 0.3 5/10* 10.8 ± 3.5** 78.7 ± 2.6** 17.28 tid × 7 beg -48 h 3/3 0.5 4/10 9.5 ± 1.6** 76.6 ± 2.0* 8.74 tid × 7 beg -48 h 3/3 1.9 3/10 8.6 ± 2.2 76.2 ± 1.8 17.28 qid × 7 beg -48 h 3/3 -0.9 2/10 9.4 ± 2.5* 76.0 ± 2.0 8.74 qid × 7 beg -48 h 3/3 -0.5 2/10 7.9 ± 1.1 75.4 ± 0.8 Ribavirin 75 bid × 5 beg -4 h 3/3 -0.8 10/10*** .sup. >21.0 ± 0.0*** 86.0 ± 2.0*** Saline -- qid × 7 beg -48 h -- -- 2/20 9.2 ± 3.0 75.4 ± 0.8 Normal Controls -- -- 5/5 1.9 -- -- 86.0 ± 1.2*** aDifference between initial weight and weight 18 h after final treatment. bMean day to death of mice dying prior to day 21. *P < 0.05; **P < 0.01; ***P < 0.001 compared to saline-treated controls.
Toxicology and Dose Ranging Study in Mice
[0033]A pilot in vivo toxicological/dose-ranging study was performed in mice to ensure the safety of the zinc metallo-ion compositions at dosage levels before commencing the prophylaxis study. Groups of 3 mice received the Zn formulations at (i) four times human recommended daily allowance (human RDA being 15 mg of elemental zinc per day) (ii) twelve times human RDA (equivalent to 1× mouse RDA) and (iii) thirty six times human RDA once daily, orally, for 14 days.
[0034]The mice were weighed before treatment started (and 18 hours after the final treatment) and observed for signs of toxicity during the dosing period. No signs of toxicity were noted. A general examination of internal organs was performed on the mice at the end of the dosing period and no overt abnormalities were observed.
[0035]Prophylactic activity in mice infected with lethal H5N1 influenza virus; namely Influenza A/Duck/MN/1525/81 (H5N1) adapted to mice.
[0036]For the prophylaxis study, groups of 10 female BALB/c (6-8 week old, around 20 g) mice received orally the zinc metallo-ion compositions diluted in distilled water at 1× and 36× human RDA ( 1/12 and 3× mouse RDA equivalent) for 3 days divided into 2 doses i.e. 1 dose am and 1 dose pm daily. The placebo group (20 mice) received distilled water twice daily.
[0037]Four hours after the last dose, mice were inoculated intranasally with the aforesaid lethal H5N1 Virus. The dosing was continued twice daily until the end of the study (21 days or mouse death).
[0038]Another group of 10 mice received Tamiflu® (oseltamivir phosphate) orally twice daily at 10 mg/kg for 5 days, starting four hours after intranasal virus inoculation. Blood oxygen levels were measured daily (providing an indication of lung function) and the mice were weighed at the beginning and end of the study.
[0039]Results up to day 19 are summarised in table 3A below, full results are in Table 3.
TABLE-US-00004 TABLE 3A Number of surviving mice Treatment Dose (mg/kg) per group at day 19 Zn 8.74 (3 × human RDA) 8/10 [80%] Zn 0.24 (1/12 human RDA) 5/10 [50%] Water/control Nil 8/20 [40%] Tamiflu ® 10 10/10 [100%]
Influenza--Infected Human Case Study
[0040]Key ZnAL42≡Example 7, SePC33≡Example 5 MnAL42=manganese metallo ion formulation based on a soluble manganese compound prepared according to the procedure described above.
[0041]An asthmatic subject who suffers badly from the effects of respiratory viruses has found on four separate occasions that taking a combination of ZnAL42, MnAL42 and SePC33 at the RDA level three times daily for 3-4 days when a cold or 'flu is starting (recognized by typical cold and 'flu prodrome effects and wheezing) completely prevents the development of the cold or 'flu. Without the combination of metallo-ion formulations this individual usually requires 4-6 days of bed rest and usually develops a chest infection that further exacerbates respiratory difficulties and prolongs the course of the illness to 2 weeks.
[0042]Several other non-asthmatic individuals regularly using the ZnAL42 product find that when symptoms of a cold or 'flu infection are starting, the infection can be curtailed by increasing the ZnAL42 dose to 3-times RDA for 2 to 5 days.
[0043]It has been reported by Johnston's group that the production of interferon-beta and -lambda by rhinovirus-infected bronchial epithelial cells from asthmatics is impaired compared to non-asthmatics. Thus, it is postulated without being bound by theory that ZnAL42 or the combination of ZnAL42, MnAL42 and SePC33 enhances anti-viral interferon production thereby ameliorating the viral infection and its pathogenic effects in the lungs.
[0044]There are now provided examples of gel based compositions containing copper metallo-ion composition.
Gel Based Composition
TABLE-US-00005 [0045] TABLE 5 RAW MATERIAL USED % by wt PHASE A ALOE VERA GEL BASE 99.00 PHASE B CU AL 42 1.0 * Copper metallo-ion Composition ≡314 ppm Cu Preparation: Step 1. Add Phase B to Phase A mixing thoroughly. N.B. the Aloe Vera Gel Base is preferably made by Hydrating 200:1 Aloe Barbadensis Flake thickening with 0.5% xanthan gum and when clear adding 0.1% Potassium Sorbate and 0.1% Sodium Benzoate. * Note: see Example 34 below.
Improved Gel Based Composition
TABLE-US-00006 [0046] TABLE 6 RAW MATERIAL USED % by wt A PURIFIED WATER 95.8 ALOE BARBADENSIS FLAKE 200:1 0.5 B XANTHAN GUM 0.5 C WATER 2.0 POTASSIUM SORBATE 0.1 SODIUM BENZOATE 0.1 D CU AL 42 1.0 * Copper metallo-ion Composition ≡314 ppm Cu Preparation: Step 1. Slowly dissolve flake aloe in water in phase A Step 2. Heat phase A to 38-40 C. Step 3. Sift xanthan gum into an established vortex in the water phase. Allow 45 minutes for the xanthan to dissolve completely. Step 4. Add predissolved Potassium Sorbate and Sodium Benzoate - phase C - to gel mixture. Mix thoroughly. Step 5. Add phase D - CU AL 42 - mix thoroughly * Note: An apparent excess of copper metallo ion composition is blended into the gel formulations, compared to the aqueous formulations. Despite the high level, the aloe base appears to mask undesirable metallic aftertastes when applied, e.g. to nasal passage.
Patent applications by Stephen Spaulding Hickok, London GB
Patent applications in class Copper
Patent applications in all subclasses Copper
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Thank you Zygmunt,
...yes what you see in the picture is all real, he was outside the men's toilette door........
How cool!! , He failed not decide. Imagine the shock front, when you come out of the toilet and a bear stands in front! Like
...oh yes! not the sort of meetings anyone may like coming out of the toilet! ha ha ha ha!
Thank you for your visit!
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Photo taken in Visalia-Porterville, CA, CA, USA