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CINCINNATI — Along with promoting flowers and chocolates, Kroger is celebrating Mother's Day in a unique way: with digital coupons that can complement a Mother's Day meal. "Pick up dinner in our store and save more than $5 with digital coupons for foods she'll love," Kroger writes on its website. Coupons include $1 off Kroger's Private Selection private-label cookies; 75 cents off Private Selection soup; and $1 off Private Selection mussels. It's also offering $1 off a heart-shaped cake. ...
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The S&P 500 and Nasdaq extend their declines on Wednesday afternoon as crude oil resumes its slide after briefly touching the flatline.
Pandora (P) reported lower-than-expected results for the 2016 third quarter late yesterday, prompting analysts to cut their ratings on the stock.
Stocks pull back from losses on Wednesday as crude oil recovers, though Apple continues to sour sentiment.
Stock futures turn lower for another day on Wednesday after Apple, the biggest weight on the S&P 500, posts a so-so quarter.

subset: commoncrawl


text:
A kebele (Amharic: ቀበሌ?, qäbäle, "neighbourhood") is the smallest administrative unit of Ethiopia similar to a ward, a neighbourhood or a localized and delimited group of people. It is part of a woreda, or district, itself usually part of a Zone, which in turn are grouped into one of the Regions based on ethno-linguistic communities (or kililoch) that comprise the Federal Democratic Republic of Ethiopia.[1] Each kebele consists of at least five hundred families, or the equivalent of 3,500 to 4,000 persons. There is at least one in every town with more than 2,000 population. A keftanya, or representative, had jurisdiction over six to twelve kebeles.
The kebele, also referred to as a peasant association, was created by the Derg in 1975 to promote development and to manage land reform; they became a key element that the rival Ethiopian People's Revolutionary Party and MEISON fought each other, and the ruling Derg, to control during the Ethiopian Red Terror. These armed members, formed into neighborhood defense squads, were responsible for many of the brutal excesses of the Red Terror.[2] Upon the Ethiopian People's Revolutionary Democratic Front assuming power at the end of the Ethiopian Civil War in 1991, it retained the peasant associations, or kebeles, but exploited their function for providing services and transformed them into a useful method of control and repression. As Human Rights Watch noted, "Kebele officials determine eligibility for food assistance, recommend referrals to secondary health care and schools, and help provide access to state-distributed resources such as seeds, fertilizers, credit, and other essential agricultural inputs. They also run the community social courts (kebele-level courts that deal with minor claims and disputes), local prisons, and, in some places, local militia that are used to maintain law and order."[3]
- ^ Population and Health in Developing Countries: Population, Health and Survival at INDEPTH Sites. ISBN 0-88936-948-8
- ^ Edmond J. Keller, Revolutionary Ethiopia: From Empire to People's Republic (Bloomington: Indiana University Press, 1991), pp. 234f
- ^ "One Hundred Ways of Putting Pressure", p. 17. Human Rights Watch report, released 10 March 2010
|This Ethiopia location article is a stub. You can help Wikipedia by expanding it.


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The brother of a man killed by a crane mounted on the back of a truck says his death has left the family reeling and searching for answers.
Mr Stack, known by his family and friends as Will-Tell, died on September 22 while walking along the Great Eastern Highway, near Williams Street, West Kalgoorlie, at about 10am with his cousin.
Mr Stack had come to Kalgoorlie-Boulder for the funeral of his cousin's daughter. The day after the funeral, the two men had taken their car to a local business to get the tyres changed.
While the cousins were walking on the footpath, Mr Stack was hit from behind by a crane mounted to a vehicle. The accident left the man with severe head injuries and he died in Royal Perth Hospital about a week later.
His brother, Wayne Stack, spoke to the Kalgoorlie Miner this week and said his family had been "lost without answers" over the incident.
He said Mr Stack worked as a plant and machine operator for a mining company in Meekatharra.
"(He) had a big heart and a big smile all the time," Wayne Stack told the Miner. "He was taken from us and we want answers."


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Tribute: Frank Peter Bestic
Frank Peter Bestic, 94, passed away October 18
Frank Peter Bestic, 94, passed away October 18
Jeanette Singer passed away October 18
Surveillance cameras captured the child fending for herself, with just a blanket, outside in the cold all night.
Millions of Social Security recipients and federal retirees will get only tiny increases in benefits next year.
The latest weather forecast for Youngstown, Warren, Austintown, Boardman, Sharon, Lisbon and East Liverpool.
Weather really doesn't play much of a role in contracting colds and the flu, but it does have an impact on those who suffer with allergies.
It was to be part of a bargain that would have allowed the FBI to deploy more agents in foreign countries, according to the files.
The campaign, dubbed "#KeepThemRuby," offers donor rewards ranging from T-shirts and tote bags to replica slippers and behind-the-scenes tou…
An Ohio sheriff says he believes whoever killed eight family members in April were from the area and not out-of-towners.
Officials say they've seized more than 130 animals from a home in a southwest Ohio village in a case they're calling a "farmyard of horrors.…
The latest weather forecast for Youngstown, Warren, Austintown, Boardman, Sharon, Lisbon and East Liverpool.
Six relievers combined for 25 outs and 128 pitches; Jason Kipnis and Mike Napoli homered.
The Cardinal Mooney girls soccer team are moving on after topping Columbiana in sectional action Monday night.
The latest weather forecast for Youngstown, Warren, Austintown, Boardman, Sharon, Lisbon and East Liverpool.
The 16-year-old was originally suspended from Hilliard Davidson High School after another student told school officials.
Police said the pedestrian ran into the center turning lane as the driver was approaching, and was hit head-on by the car.
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There are just 200 bins left of the 21,000 originally bought, and the city needs another truck for backup.
Pence said Americans are "rising up" and that Trump will bring "real change" to the country.
Carr ran for 200 yards, and scored four touchdowns against state-ranked Wilmington last Friday.
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Just make your Parts Express online purchase total more than $100.00 in merchandise and we will ship it fast and ship it free to you.
Free Shipping Offer Details/Exclusions:
The M97xE is a superbly tracking, neutral, smooth-sounding magnetic cartridge designed to provide long hours of undistorted, easy listening without fatiguing the ear or tiring the mind. This cartridge is able to accurately reproduce very difficult musical passages, particularly in the high-frequency range, where audio modulations are the smallest and most concentrated, and stylus tip movement is consequently the most rapid. Its highly precise tracking ability and flat frequency response are made possible by Shure's unique Type II low-mass thin-wall aluminum alloy stylus cantilever, combined with a precision-crafted, finely polished, elliptical diamond tip. Includes screws.
The very low mass M97xE cartridge shares several important features with the V15VxMR audiophile cartridge such as Shure's exclusive viscous-damped Dynamic Stabilizer, which maintains a uniform distance between the cartridge and the record under difficult playing conditions, such as those caused by warped records, or mismatched tonearm mass. When such stabilization is not required, the stabilizer brush can be locked up into its detent position, which, under ideal playing conditions, can provide even better sound quality. A die cast aluminum mounting block provides secure, vibration-free attachment to the tonearm while the SIDE-GUARD stylus protection system helps prevent stylus damage if the cartridge accidentally slides across a record. This unique feature responds to side thrusts on the stylus by withdrawing the entire stylus cantilever and tip safely into the stylus housing before the cantilever can be damaged.
Specifications: • Dynamic stabilizer damper/de-staticizer • Die-cast aluminum mounting block • Side Guard stylus protection system • Tone arm mount: Standard 1/2" • Cartridge type: Moving magnet • Cantilever: Shure Type II, very low mass heat-treated aluminum alloy/tubular, 1.0 mil wall thickness, 20 mil diameter • Diamond stylus tip: Polished natural gemstone, elliptical, side x front radii: 0.2 x 0.7 mil • Tracking force range (effective at stylus tip): 0.75 to 1.50 grams, optimum: 1.25 grams • Trackability at 1 gram tracking force (cm per second peak velocity): 1 kHz: 44 cm/sec, 10 kHz: 31 cm/sec • Amplitude: 80 um at 400 Hz • Frequency response: Essentially flat from 20 to 22,000 Hz • Stereo channel balance: Within 2.0 dB • Channel separation (typical at 1 kHz): 25 dB • Output voltage (typical at 1 kHz): 4.0 mV RMS at 5 cm/sec peak velocity • Net Weight: 6.6 grams • Height: 15.875 mm • Accessories Included: Headshell screwdriver, stylus cleaning brush, user guide, mounting hardware and stylus guard • Full one-year manufacturer's warranty • N97xE replacement stylus #232-507.
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The result? SpotGenie created a premium product that is technologically advanced and simple to use, backed by the best operations and customer service in the industry. This successful approach is now extended to our asset security, talent usage and traffic instructions management services.
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Cake is frosted and decorated in buttercream. The roses and cake sides are white buttercream sprayed with Wilton color spray and dusted with pearl luster dust for a shimmer.
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Wednesday, October 26, 2016 • 11:30am-1:30pm • The Sentinel Hotel (Governor Ballroom)
614 SW 11th Ave, Portland, OR 97205
Click Here to See the 2016 Award Winners
DJC's Women of Vision is an educational and awards luncheon program that supports the women who are shaping our built environment with their leadership, mentoring efforts, community involvement and the promotion of industry diversity. The long lunch kicks off with a handful of presentations by national speakers and local industry professionals focused on various aspects of professional development and local issues related to women in the building and supporting industries. The educational aspect is followed by the Women of Vision awards luncheon, which celebrates the distinct accomplishments of leading women in the built environment. The event also offers several chances for open, friendly networking with attendees and the various speakers.
Please contact Bill Beyer at email@example.com or calling (503) 802-7232
Nomination Deadline: August 19, 2016
Advertising Deadline: October 12, 2016
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(Illinois State Water Survey, 1982)A technique was developed for algal toxicity assays. Algal communities obtained from several sewage treatment plants and surface waters were the test specimens. The toxicant used was zinc acetate The techniques that were ...
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(2008)To gain greater insight into the operation of online social networks, we applied Natural Language Processing (NLP) techniques to text-based communication to identify and describe underlying social structures in online ...
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(2010)This article proposes the use of content clouds as a method of exploratory qualitative data analysis. Content clouds are a type of visualization that summarizes the contents of a document by depicting the words that appear ...
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(2009-02-08)The multidisciplinary approach adopted by iSchools is a source of both strength and confusion. Novel research agendas and approaches emerge from the cross-pollination of ideas among students and faculty with diverse ...
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(2009-02-08)We propose a roundtable discussion on the role of philosophers, and philosophical topics and methods, in the mission of the iSchools, including research, education, and outreach.
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(iSchools, 2016-03-15)This poster presents a case study method developed for a pilot study investigating the evaluation of print- and text-based consumer health information by individuals who have low or limited literacy skills in English. The ...
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(2014-05-30)This study investigates the perspectives of language teachers on language and language teaching at a democratic school in São Paulo, Brazil. The commentary of the one former English teacher is central to the analysis, ...
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Web historian: enabling multi-method and independent research with real-world web browsing history data (iSchools, 2016-03-15)Research analyzing real-world web browsing data has generally been collected from digital service providers or the online panelists of corporate research panels. These approaches limit the replicability and the kind of ...
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(iSchools, 2014-03-01)As organizations produce ever-larger torrents of text, images, sounds and numbers we find an increased attention to how researchers and organizational members alike can gain insights from these traces of social practices. ...
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This business is not BBB accredited.
Green Medical Billing Service
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People seeking AIDS treatment or preventatives can protect themselves by avoiding promotions claiming to be "Miraculous", "secret", or "foolproof". People should also watch for experimental treatments that carry a big price tag and claims that testing has been done in another country. U.S. Food and Drug Administration has approved only one drug so far: zidovudine or AZT, for treatment of AIDS.
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Carlsbro Cobra 90 Twin Guitar Amp
Asking price: €150
- Seller:
- McSemtex
- Feedback:
6 0
- Location:
- Cork
- Entered/Renewed:
- 6 years ago
- Ad Views:
- 1,633
This is a Carlsbro 90 watt guitar amp, with built in Gain, Reverb, Overdrive and FX loop. 2 channels and a 4 band Eq. This amp has a great range of sound and volume. Perfect for practice or gigging.
Shipping: Collection
Payment: Cash
Hi There Galantie, Sorry for taking so long to get back to you. Don't know how old the amp is because I bought it 2nd hand but it is in good condition. If you'll stretch to €120 we'd have a deal. Cheers


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The Maine Game Wardens stake out a field at night to catch hunters illegally illuminating wildlife.
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In this deleted scene, Jimmy gets a call about snakes in someone's backyard. He discovers some very venomous water moccasins, the kind that could kill a person with one bite.
Gator Boys: Stay Back From the Gators
When volunteer Ashley gets too close to the gators, Paul blows up and questions her motivations for working at the rescue. For good reason: a few years back, he got too close himself and almost lost some fingers.
Gator Boys: Gator in My Swimming Pool
The Gator Boys (Paul and Jimmy) get a call from a woman who has an alligator in her swimming pool. What happens next is almost unbelievable.
Ned Bruha Skunk Whisperer: Hosing Down a Raccoon
Chris and Stormy come up with a genius plan to get a raccoon out of a tree - by climbing up on a roof and hosing it down.
Beast Tracker: Gator Egg Round Up
Dr. Andrew West meets with scientists at a wild animal refuge to observe an alligator nest. Biologist Ruth Elsey explains how a slight temperature variation can produce a major difference in hatchlings.
My Extreme Animal Phobia: Man Scared of Bees
Dr. Zasio has Kurt come face-to-face with his fear of bees, and he has them eating right out of the palm of his hand.
Monster Bug Wars: Vinegaroon Vs. Spider
It's a heavy weight match up when an unsuspecting spider is confronted with an angered vinegaroon.
Infested: Pennsylvania Home Overrun with Roaches
A condemned house in Pennsylvania is infested with cockroaches and the madness spills in to the house next door. These owners have had enough.
My Extreme Animal Phobia: Woman's Shark Phobia Tested
Shelly must come face to face with her fear of sharks, and the sharks are making sure they give her a run for her money.
Infested: Roaches Wreck Family's Dream
An Arizona couple and their children start fresh with a new home but soon find that they aren't the only tenants. An infestation of roaches is destroying their electronics and ruining their home.
Call of the Wildman: Skunk Cornered in Shed
Turtleman's least favorite animal is a skunk but duty calls. A whole family of skunks has been cornered in a shed and he has to dawn some ridiculous gear to go after them.
Infested: Four Year Old Attacked By Bats
When their home was invaded by bats they never thought that they would actually attack anyone... but they were wrong and their four year old son has to be rushed to the hospital.
River Monsters: How to Noodle a Flathead Catfish
Jeremy Wade is known for his expertise with a rod and reel, but here he explains how he caught a dog-sized flathead catfish in the rivers of Oklahoma using nothing but his hands.
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Jeremy is out at night to try and catch a bull shark, but what ends up on his line shocks him. A gigantic 750 pound grouper with massive spikes on its back is definitely not what he had in mind.
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Eric and Rick track a rare, poisonous Mexican Beaded Lizard.
Rattlesnake Republic: Sleeping With Snakes
In hopes of setting a new record, Robert climbs into a sleeping bag full of dangerous snakes while a crowd watches eagerly.
Rattlesnake Republic: It's a Texas Thing
Deep in the heart of Texas lies the "Rattlesnake Republic," a wild land ruled by one of earth's deadliest predators. This deadly country has become the epicenter of a million dollar industry.
Rattlesnake Republic: Swimming With Rattlesnakes
Rick makes a dangerous mistake when he jumps into a pool to capture an aggressive rattlesnake.
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Crawling into a cave seems like a straightforward task until Jack makes a terrifying discovery: there's a rattlesnake on his arm.
Rattlesnake Republic: How to Catch a Diamondback
In this deleted scene, Dalton takes his final training test: catching and boxing a diamondback rattlesnake. Will he be able to capture the snake without injuring himself?
North Woods Law: Bear Loose in Portland, Maine
An adult bear wanders around a neighborhood in Portland. Can the Game Warden on scene keep the inhabitants safe without harming the bear?
North Woods Law: Busting Bad Guys
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Dr. Andrew West wants to see how sharks will react to humans being in open water with them. What better way to do this than jump right on in with the sharks?
Beast Tracker: Unforgettable Morning
A shark attack victim tells Dr. Andrew West his story.


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Dymon Hearing Center
71 Walnut Blvd Ste 108 Rochester, MI 48307
Clinic staff
Malcolm McAdam
Malcolm McAdam has an extensive background in clinical, educational, and industrial audiology for both children and adults. He provides audiology services for six county health departments, the State of Michigan, and a leading healthcare clinic. Our patients receive the benefits of his extensive background, expertise and counseling.
Debbie Dymon
Debbie Dymon earned her Bachelor's degree in Audiology from Michigan State University. She has over 20 years of experience in fitting and servicing hearing aids and is the owner and president of Dymon Hearing Center. She worked for Lucas Hearing Aid for 19 years at the Rochester location before purchasing it herself in 2007.
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About this clinic
At Dymon Hearing Center we offer comprehensive hearing solutions through patient education, state of the art technology, and experienced professional care. We are committed to providing quality service and dedication to our customers. Our main goal is to provide you with the best possible hearing care solution based on your individual needs.
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We offer a full range of hearing services available to patients of all ages.
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(248) 841-4519
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Birth of America 2: Wars in America is the long-awaited epic sequel to the acclaimed Birth of America. In this sweeping historic strategy title, replay three of the greatest conflicts that forever changed world history: The French and Indian War, The American Revolution & Mr. Madison's War.
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Below are some frequently asked questions about Transfer Student Orientation. Click each topic below to see the questions in that category. Click on a question to see the answer. General
What is the purpose of orientation?
Orientation is an event for all new students at Northeastern Illinois University. You'll meet with an academic advisor to create your class schedule, in addition to learning other essential information that will help you as a student.
Is Transfer Student Orientation Mandatory?
No, however orientation is strongly encouraged for all new transfer students at NEIU. This program will help with your transition into your new community.
If you are transferring less than 60 credit hours or are undecided as to your major, you REQUIRED to meet with an advisor in the Academic Advisement Center. Advisors are available on a walk-in basis, Monday thru Thursday 8:00 a.m. until 3:15 p.m. and Friday's from 8:00 a.m. till 1:00 p.m. You can also call (773) 442-5470.
If you have earned an A.A. or an A.S. degree and have already decided upon your major, we strongly encourage you to contact an advisor in your intended major college or department prior to registering for your first semester of classes.
Why should I attend?
On the day of orientation you will:
- Meet with your academic college and learn about degree requirements for your major
- Learn about Financial Aid and ways to pay for college
- Meet with other new transfer students
- Get your student ID
- Learn about the many support services available to students
- Find out more about student organizations and opportunities to get involved on campus
How long is Orientation?
Orientation is a one day program starting in the morning and ending in the afternoon. This day has been carefully designed to assist you in your transition into Northeastern.
Do I really have to attend the whole day?
Transfer orientation is not required, but we do hope that if you attend orientation that you would stay for the whole program. Our goal is to assist you with your transition and answer any questions you might have before you start classes.
I am transferring from another college, but I am classified as a freshman. Do I attend
first-year orientation or transfer orientation?
If you are classified as a freshman, then you are slated to attend one of our first-year orientation sessions, which will be very helpful to you as you transition into NEIU.
Change your transfer student orientation date and attendance
How can I switch my transfer student orientation date?
You can switch your orientation date by calling new Student and Family Programs at (773) 442-5476. Dates are available on a first-come, first-served basis due to program space limitations. There is no waiting list for orientation dates.
Is there a wait list for Orientation Dates?
There is no waiting list for orientation. When changing your date you must pick a date with space availability. Dates are available on a first-come, first-served basis due to program limitations. For this reason, we cannot accommodate students coming on the wrong date.
What happens if I miss my orientation date?
It is extremely important that you do not miss your orientation date, but we know that sometimes things happen in our life. Please call New Student and Family Programs at (773) 442-5476 and let us know and we'll reschedule your orientation date. If you do not contact our office to reschedule, we will send out a reminder e-mail to reschedule your orientation date.
What happens if I am going to be late for orientation?
If you are running late, please contact our office immediately at (773) 442-5476. At that time, our office staff will let you know if you should come to orientation or reschedule for another time.
I made travel arrangements and I have to leave early/arrive late, is that ok?
If you need to meet with an advisor and enroll for classes, you must attend the entire orientation program. Please keep this in mind when you are making your travel arrangements.
If I attend orientation at the end of the summer, will I have to take 8:00 am classes?
If you request to meet with and an academic advisor, they will help you choose classes that best meet your academic needs. However, you will have more class options the sooner you attend orientation, so don't wait--Register Now.
What if I get sick or have a family emergency during Orientation?
We certainly hope this does not happen! If this does occur, please call the New Student and Family Programs Office (773) 442-5476 immediately. You can reschedule and finish completing the program on another date of your choice.
Can I change my intended major at Transfer Student Orientation?
Students are encouraged to change their intended major prior to their Orientation date. You will meet with your academic college based on your intended major. If you decide to change your intended major, please call New Student and Family programs at (773) 442-5476.
Orientation Registration
How do I register for Transfer Student Orientation?
You can register online. Before you register for your orientation date, please read the rest of this Orientation Registration section.
What if I don't know my Student ID Number?
Please contact New Student and Family Programs at 773-442-5476 for assistance.
What is NEIUport and how do I use it?
At Orientation, you will be asked to log into your NEIUport account to register for classes. NEIUport is NEIU's university-wide internet portal. This portal provides quick, centralized, and secure access to information and services for all NEIU students, faculty, and staff.
Your NEIUport account allows you to:
- Register for classes online
- View course seating capacities (open or closed classes)
- Determine course prerequisites
- Print out a class schedule
- View grades and transcripts
- Request official transcripts
- Review Financial Aid awards
- Print out a tuition and fees statement
- Pay tuition and fees online with credit, debit or check
How do I Obtain a NEIUport NetID and Password?
NEIUport accounts are automatically created for students admitted to NEIU. An NEIU Online Connection! letter is sent shortly after admission acceptance. If you did not receive a letter, you can look up your NEIUport NetID and password. Please go to http://neiuport.neiu.edu. You will need to enter your NEIU student ID number and date of birth.
I'm having problems with my NEIUPort account. Who can help me?
If you continue to have problems logging in to your NEIUport account, please contact Technology Services by e-mail at firstname.lastname@example.com, or by phone at 773-442-4357, Monday through Friday between the hours of 8:30 a.m. and 4:30 p.m.
Fees and Tuition
How do I pay for Transfer Student Orientation?
The orientation fee will automatically be added to your student account.
Is there a cost for Transfer Student Orientation?
Should I bring money to pay for my tuition at Orientation?
No, you will not need to pay for your tuition during Orientation. NEIU uses an electronic billing (e-billing) service. You will receive an e-mail notification to your NEIUport account when your e-bill is available for viewing. You are responsible to have your tuition and fees paid by the due dates. You will be responsible for all late fees regardless of the status of a bill. Please be aware of payment deadlines on the Tuition and Fees Payment Schedule (available here under the links for "Detailed Calendars".)
Will I be able to meet with Financial Aid during Transfer Student Orientation?
Yes. There are presentations about Financial Aid and Scholarships during Orientation. In addition, you are welcome to stop by the Financial Aid Office and speak with a representative as time permits within the orientation schedule. The Financial Aid Office is located in D Building, Room 200 (second level, above Enrollment and Student Payment Services).
Can my family come to Orientation with me?
We STRONGLY encourage you NOT to bring any additional guests with you to transfer student orientation. This program is designed for our students and not any additional guests. If your guests do attend with you, they will not be allowed to participate in student activities during transfer orientation
I have a disability. What accommodations can be made for me at Orientation?
If special assistance or auxiliary aids are needed to accommodate a disability, please contact Student Disability Services (SDS) at NEIU 773-442-4595 or email email@example.com to schedule an appointment to discuss any accommodations. Some services may take longer to put into place than others, so we strongly advise contacting Student Disability Services 2 weeks prior to your orientation date.
I have difficulty walking long distances. Will I be able to fully participate in Orientation?
A walking campus tour is part of the orientation program; however we are not equipped to provide transportation assistance (Such as wheelchairs or golf carts). If you are coming to Orientation and you have any permanent or temporary disabilities or special needs which may require advance arrangements for assistance, please contact Northeatern's Student Disability Services (SDS) at (773) 442-4595 or email email@example.com at least 2 weeks before your orientation date.
What's Next?
Once I leave Transfer Student Orientation, where do I go for help?
Advisors, faculty, counseling staff, administrative staff, students and many others are all ready to help you! Also, the NEIU Homepage is a great source of information, if you have questions regarding academics, Financial Aid, Student Involvement, etc. Conducting a search is easy. We have so many great resources on campus just waiting to be used!
Still have questions about transfer orientation? Please contact New Student and Family Programs at 773-442-5476 or firstname.lastname@example.com.


text:
Just ask him and he'll tell you. Harry Adams isn't afraid to admit it.
AU WR commit adjusting well in 2nd year
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Texas Values President Loses Wife
BTL Staff
Originally printed 8/15/2014 (Issue 2233 - Between The Lines News)
TEXAS - President of Texas Values, a large anti-gay group in Texas, Jonathan Saenz is known for his opposition of gay rights, his anti-abortion stance and his defense for conservatives to have the right to force their religion on other people. But Saenz never made anti-gay activism a big part of his career benchmark until 2012.
What caused his sudden interest in opposing gay rights?
Court documents recently revealed that his now ex-wife left him in 2011 for another woman.
Since he started focusing his attention on his ex spouse and her new community Saenz has endorsed gay conversion therapy, claimed that same-sex marriage will lead to polygamy and people marrying their step-children, suggested that the LGBT community wants to put Christians into concentration camps and strongly opposes nondiscrimination ordinances in San Antonio and Houston.
More National
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- N. Carolina's Religious-Exemption Gay Marriage Bill Now Law
- N. Carolina Gay-Marriage Law May Mean Long Courthouse Waits
- Thousands Converge On Indianapolis For Annual LGBT Parade
- Health Officials Work With LGBT Groups To Fight Outbreak
- Gay Adoption Ban Stricken From Florida Laws After Four Decades
- Police Investigate After Man Has Gay Slur Carved Into Arm
- Poll: Most Americans Expect Supreme Court To OK Gay Marriage
- Gay Adoption Ban Stricken From Florida Laws After 4 Decades
- Poll: Most Americans Expect Supreme Court To OK Gay Marriage
- Supreme Court: Why The Abercrombie Decision Matters
- Fed Agencies Release Guide On LGBT Discrimination
- HRC And Whitman-Walker Health Partner To Make Sexual Health A Priority For LGBT
- Williams Institute Finds Erasing Gender Wage Gap Would Reduce LGBT Poverty
- Garrett Miller Releases 'Gay Wedding,' Adaption Of Billy Idol's 'White Wedding'
- The Nation Reacts To Caitlyn Jenner
- Valedictorian Gives Coming Out Speech At Gay Rights Awards
- Gay Marriage Challenge Cost Indiana $1.4M In Attorney Fees
- Study Finds Same-Sex Marriage Impacts LGBT Couples More Directly Than Their Heterosexual Siblings
- Proposal For 'Straight Pride' Club Spurs Calls For Training
- Presidential Proclamation -- LGBT Pride Month, 2015
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- Adam Lambert Reveals He Dressed 'Outlandishly' Because He Was 'Overcompensating,' Talks Lack Of Gay Artists
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- Creep of the Week: Rick Snyder
- Q&A: Rose Byrne Speaks Out On Hollywood Sexism ('It's Discrimination'), Talks Drag Inspirations & Playing Gay
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Lake Effect
Hot off Season 7 of the LOGO channel's "Ru Paul's Drag Race" phenomenon, Darienne Lake of Season 6 spoke with Between the Lines about her upcoming hosting gig at Motor City Pride June 6.View More Pride Guide
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Most Cited Cancer Letters Articles
The most cited articles published since 2011, extracted from Scopus.
Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cellsBin Bao | Zhiwei Wang | Shadan Ali | Dejuan Kong | Yiwei Li | Aamir Ahmad | Sanjeev Banerjee | Asfar S. Azmi | Lucio Miele | Fazlul H. Sarkar
Volume 307, Issue 1, August 2011, Pages 26-36
Activation of Notch-1 is known to be associated with the development and progression of human malignancies including pancreatic cancer. Emerging evidence suggest that the acquisition of epithelial-mesenchymal transition (EMT) phenotype and induction of cancer stem cell (CSC) or cancer stem-like cell phenotype are interrelated and contributes to tumor recurrence and drug resistance. The molecular mechanism(s) by which Notch-1 contributes to the acquisition of EMT phenotype and CSC self-renewal capacity has not been fully elucidated. Here we show that forced over-expression of Notch-1 leads to increased cell growth, clonogenicity, migration and invasion of AsPC-1 cells. Moreover, over-expression of Notch-1 led to the induction of EMT phenotype by activation of mesenchymal cell markers such as ZEB1, CD44, EpCAM, and Hes-1. Here we also report, for the first time, that over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. Re-expression of miR-200b led to decreased expression of ZEB1, and vimentin, and increased expression of E-cadherin. Over-expression of Notch-1 also increased the formation of pancreatospheres consistent with expression of CSC surface markers CD44 and EpCAM. Finally, we found that genistein, a known natural anti-tumor agent inhibited cell growth, clonogenicity, migration, invasion, EMT phenotype, formation of pancreatospheres and expression of CD44 and EpCAM. These results suggest that the activation of Notch-1 signaling contributes to the acquisition of EMT phenotype, which is in part mediated through the regulation of miR-200b and CSC self-renewal capacity, and these processes could be attenuated by genistein treatment. © 2011 Elsevier Ireland Ltd.
DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosisWynand P. Roos | Bernd Kaina
Volume 332, Issue 2, May 2013, Pages 237-248
DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the apoptotic executing pathways can be elucidated. Here, we describe specific DNA lesions that have been identified as apoptosis triggers, their repair and the signaling provoked by them. We discuss methylating agents such as temozolomide, ionizing radiation and cisplatin, all of them are important in cancer therapy. We show that the potentially lethal events for the cell are O6-methylguanine adducts that are converted by mismatch repair into DNA double-strand breaks (DSBs), non-repaired N-methylpurines and abasic sites as well as bulky adducts that block DNA replication leading to DSBs that are also directly induced following ionizing radiation. Transcriptional inhibition may also contribute to apoptosis. Cells are equipped with sensors that detect DNA damage and relay the signal via kinases to executors, who on their turn evoke a process that inhibits cell cycle progression and provokes DNA repair or, if this fails, activate the receptor and/or mitochondrial apoptotic cascade. The main DNA damage recognition factors MRN and the PI3 kinases ATM, ATR and DNA-PK, which phosphorylate a multitude of proteins and thus induce the DNA damage response (DDR), will be discussed as well as the downstream players p53, NF-κB, Akt and survivin. We review data and models describing the signaling from DNA damage to the apoptosis executing machinery and discuss the complex interplay between cell survival and death. © 2012 Elsevier Ireland Ltd.
Long non-coding RNAs: A new frontier in the study of human diseasesXuefei Shi | Ming Sun | Hongbing Liu | Yanwen Yao | Yong Song
Volume 339, Issue 2, October 2013, Pages 159-166
With the development of whole genome and transcriptome sequencing technologies, long noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that lncRNAs act not only as the intermediary between DNA and protein but also as important protagonists of cellular functions. LncRNAs can regulate gene expression in many ways, including chromosome remodeling, transcription and post-transcriptional processing. Moreover, the dysregulation of lncRNAs has increasingly been linked to many human diseases, especially in cancers. Here, we reviewed the rapidly advancing field of lncRNAs and described the relationship between the dysregulation of lncRNAs and human diseases, highlighting the specific roles of lncRNAs in human diseases. © 2013 Elsevier Ireland Ltd.
Anti-angiogenesis therapy in cancer: Current challenges and future perspectivesFarbod Shojaei
Volume 320, Issue 2, July 2012, Pages 130-137
It has been nearly 9. years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical investigations have identified major drawbacks associated with the application of this class of agents, including inherent/acquired resistance and induction of tumor invasiveness. In addition, lack of thoroughly validated predictive biomarkers has been one of the major hurdles to stratify cancer patients and to monitor tumor progression and response to the therapy. Investigations in clinic and preclinical models have provided some molecular and cellular mechanisms for the above challenges. This review aims to provide a concise update from recent findings. © 2012 Elsevier Ireland Ltd.
Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expressionMing Luo | Zuowei Li | Wei Wang | Yigang Zeng | Zhihong Liu | Jianxin Qiu
Volume 333, Issue 2, June 2013, Pages 213-221
lncRNA H19 is essential for human tumor growth. However, little is known about whether H19 regulates bladder cancer metastasis. Here we found that H19 levels are remarkably increased in bladder cancer tissues, and upregulated H19 promotes bladder cancer cell migration in vitro and in vivo. H19 is associated with enhancer of zeste homolog 2 (EZH2), and that this association results in Wnt/β-catenin activation and subsequent downregulation of E-cadherin. A significant negative correlation is also observed between H19 levels and E-cad levels in vivo. These data suggest that upregulated H19 enhances bladder cancer metastasis by associating with EZH2 and inhibiting E-cad expression. © 2013 Elsevier Ireland Ltd.
Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancerHanshao Liu | Lin Zhu | Bingya Liu | Liu Yang | Xianxin Meng | Wei Zhang | Yueyun Ma | Huasheng Xiao
Volume 316, Issue 2, March 2012, Pages 196-203
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187 *, miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection. © 2011 Elsevier Ireland Ltd.
Angiopoietins in angiogenesisErnesta Fagiani | Gerhard Christofori
Volume 328, Issue 1, January 2013, Pages 18-26
Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have been a major focus of angiogenesis research. Tie-1 and Tie-2 are essential for vascular maturation during developmental, physiological and pathological angiogenesis. Angiopoietin 1-4 (Ang-1-4) have been identified as bona fide ligands of the Tie-2 receptor, while Tie-1 remains an orphan receptor which is able to heterodimerize with Tie-2 and to modulate Tie-2 signal transduction. The most exhaustively studied angiopoietins are Ang-1 and Ang-2. Ang-1 is a critical player in vessel maturation and it mediates migration, adhesion and survival of endothelial cells. Ang-2 disrupts the connections between the endothelium and perivascular cells and promotes cell death and vascular regression. Yet, in conjunction with VEGF, Ang-2 promotes neo-vascularization. Hence, angiopoietins exert crucial roles in the angiogenic switch during tumor progression, and increased expression of Ang-2 relative to Ang-1 in tumors correlates with poor prognosis. Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer. © 2012 Elsevier Ireland Ltd.
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injuryEdouard I. Azzam | Jean Paul Jay-Gerin | Debkumar Pain
Volume 327, Issues 1-2, December 2012, Pages 48-60
Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target macromolecules or via products of water radiolysis. Further, the oxidative damage may spread from the targeted to neighboring, non-targeted bystander cells through redox-modulated intercellular communication mechanisms. To cope with the induced stress and the changes in the redox environment, organisms elicit transient responses at the molecular, cellular and tissue levels to counteract toxic effects of radiation. Metabolic pathways are induced during and shortly after the exposure. Depending on radiation dose, dose-rate and quality, these protective mechanisms may or may not be sufficient to cope with the stress. When the harmful effects exceed those of homeostatic biochemical processes, induced biological changes persist and may be propagated to progeny cells. Physiological levels of reactive oxygen and nitrogen species play critical roles in many cellular functions. In irradiated cells, levels of these reactive species may be increased due to perturbations in oxidative metabolism and chronic inflammatory responses, thereby contributing to the long-term effects of exposure to ionizing radiation on genomic stability. Here, in addition to immediate biological effects of water radiolysis on DNA damage, we also discuss the role of mitochondria in the delayed outcomes of ionization radiation. Defects in mitochondrial functions lead to accelerated aging and numerous pathological conditions. Different types of radiation vary in their linear energy transfer (LET) properties, and we discuss their effects on various aspects of mitochondrial physiology. These include short and long-term in vitro and in vivo effects on mitochondrial DNA, mitochondrial protein import and metabolic and antioxidant enzymes. © 2012 Elsevier Ireland Ltd.
Tumor necrosis factorWen Ming Chu
Volume 328, Issue 2, January 2013, Pages 222-225
Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions. Then, it will focus on new findings on the molecular mechanisms of how TNF triggers activation of the NF-κB and AP-1 pathways, which are critical for expression of pro-inflammatory cytokines, as well as the MLKL cascade, which is critical for the generation of ROS in response to TNF. Finally, this review will briefly summarize recent advances in understanding TNF-induced cell survival, apoptosis and necrosis (also called necroptosis). Understanding new findings and emerging concepts will impact future research on the molecular mechanisms of TNF signaling in immune disorders and cancer-related inflammation. © 2012 Elsevier Ireland Ltd.
Targeting heat shock proteins in cancerGaëtan Jego | Adonis Hazoumé | Renaud Seigneuric | Carmen Garrido
Volume 332, Issue 2, May 2013, Pages 275-285
Heat shock proteins (HSPs) HSP27, HSP70 and HSP90 are powerful chaperones. Their expression is induced in response to a wide variety of physiological and environmental insults including anti-cancer chemotherapy, thus allowing the cell to survive to lethal conditions. Different functions of HSPs have been described to account for their cytoprotective function, including their role as molecular chaperones as they play a central role in the correct folding of misfolded proteins, but also their anti-apoptotic properties. HSPs are often overexpressed in cancer cells and this constitutive expression is necessary for cancer cells' survival. HSPs may have oncogene-like functions and likewise mediate "non-oncogene addiction" of stressed tumor cells that must adapt to a hostile microenvironment, thereby becoming dependent for their survival on HSPs. HSP-targeting drugs have therefore emerged as potential anti-cancer agents. This review describes the different molecules and approaches being used or proposed in cancer therapy based on the in inhibition of HSP90, HSP70 and HSP27. © 2010 Elsevier Ireland Ltd.
Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancerRadhamani Kannaiyan | Muthu K. Shanmugam | Gautam Sethi
Volume 303, Issue 1, April 2011, Pages 9-20
Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and generally used for the treatment of inflammatory and auto-immune diseases. Celastrol has attracted great interest recently, especially for its potential anti-inflammatory and anti-cancer activities. The anti-inflammatory effects of this triterpene have been demonstrated in animal models of different inflammatory diseases, including arthritis, Alzheimer's disease, asthma, and systemic lupus erythematosus. This triterpene has also been found to inhibit the proliferation of a variety of tumor cells and suppress tumor initiation, promotion and metastasis in various cancer models in vivo. Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch-1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, topoisomerase II, potassium channels, and heat shock response has been reported. This review describes the various molecular targets of celastrol, cellular responses to celastrol, and animal studies with celastrol in cancer and other inflammatory disorders. © 2010 Elsevier Ireland Ltd.
Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cellsYukihiro Akao | Shunsuke Noguchi | Akio Iio | Keitaro Kojima | Takeshi Takagi | Tomoki Naoe
Volume 300, Issue 2, January 2011, Pages 197-204
MiR-34a was identified as one of the down-regulated micro-RNAs (miRs) in human colorectal cancer 5-fluorouracil (5-FU)-resistant DLD-1 cells compared with those in the parental DLD-1 cells. Exposure to 5-FU at 30μM activated phosphoinositide 3-kinase (PI3K)/Akt signaling markedly from 12. h up to 48. h in the 5-FU-resistant cells compared with that in the parental cells and resulted in an overt difference in growth at those times. Furthermore, the expression of miR-34a in the 5-FU-resistant cells was sustained at a low-level, whereas it was up-regulated in the parental cells after the 5-FU treatment. Sirt1, which is one of the target genes for miR-34a and related to drug-resistance, was strikingly up-regulated in the 5-FU-resistant cells. The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth, as in the parental cells, and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3. Moreover, the silencing of Sirt1 significantly canceled the resistance to 5-FU in the 5-FU-resistant cells. These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate, at least in part, the resistance to 5-FU in human colorectal cancer DLD-1 cells. © 2010 Elsevier Ireland Ltd.
Cancer genetics and genomics of human FOX family genesMasuko Katoh | Maki Igarashi | Hirokazu Fukuda | Hitoshi Nakagama | Masaru Katoh
Volume 328, Issue 2, January 2013, Pages 198-206
Forkhead-box (FOX) family proteins, involved in cell growth and differentiation as well as embryogenesis and longevity, are DNA-binding proteins regulating transcription and DNA repair. The focus of this review is on the mechanisms of FOX-related human carcinogenesis. FOXA1 is overexpressed as a result of gene amplification in lung cancer, esophageal cancer, ER-positive breast cancer and anaplastic thyroid cancer and is point-mutated in prostate cancer. FOXA1 overexpression in breast cancer and prostate cancer is associated with good or poor prognosis, respectively. Single nucleotide polymorphism (SNP) within the 5'-UTR of the FOXE1 (TTF2) gene is associated with thyroid cancer risk. FOXF1 overexpression in breast cancer is associated with epithelial-to-mesenchymal transition (EMT). FOXM1 is overexpressed owing to gene amplification in basal-type breast cancer and diffuse large B-cell lymphoma (DLBCL), and it is transcriptionally upregulated owing to Hedgehog-GLI, hypoxia-HIF1α or YAP-TEAD signaling activation. FOXM1 overexpression leads to malignant phenotypes by directly upregulating CCNB1, AURKB, MYC and SKP2 and indirectly upregulating ZEB1 and ZEB2 via miR-200b downregulation. Tumor suppressor functions of FOXO transcription factors are lost in cancer cells as a result of chromosomal translocation, deletion, miRNA-mediated repression, AKT-mediated cytoplasmic sequestration or ubiquitination-mediated proteasomal degradation. FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504. FOXP1 overexpression is associated with poor prognosis in DLBCL, gastric MALT lymphoma and hepatocellular carcinoma but with good prognosis in breast cancer. In neuroblastoma, the entire coding region of the FOXR1 (FOXN5) gene is fused to the MLL or the PAFAH1B gene owing to interstitial deletions. FOXR1 fusion genes function as oncogenes that repress transcription of FOXO target genes. Whole-genome sequencing data from tens of thousands of human cancers will uncover the mutational landscape of FOX family genes themselves as well as FOX-binding sites, which will be ultimately applied for cancer diagnostics, prognostics, and therapeutics. © 2012 Elsevier Ireland Ltd.
Methylation of multiple genes as a candidate biomarker in non-small cell lung cancerYouwei Zhang | Rui Wang | Haizhu Song | Guichun Huang | Jun Yi | Yun Zheng | Jinghua Wang | Longbang Chen
Volume 303, Issue 1, April 2011, Pages 21-28
Aberrant DNA methylation is a common phenomenon in human cancer. The aims of this study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in the Chinese population. Twenty tumor suppressor genes (TSGs) were determined of the methylation status using methylation-specific PCR in 78 paired NSCLC specimens and adjacent normal tissues, as well as in 110 Stage I/II NSCLC and 50 cancer-free plasmas. The results showed that, nine genes (APC, CDH13, KLK10, DLEC1, RASSF1A, EFEMP1, SFRP1, RARβ and p16INK4A) demonstrated a significantly higher frequency of methylation in NSCLC compared with the normal tissues (P≤0.001), while the others (RUNX3, hMLH1, DAPK, BRCA1, p14ARF, MGMT, NORE1A, FHIT, CMTM3, LSAMP and OPCML) showed relatively low sensitivity or specificity. Furthermore, methylation of multiple genes was more frequentin cancerous tissue, CpG island methylator phenotype positive (CIMP+) cases were detected in 65.38% of (51/78) NSCLC while only in 1.28% (1/78) of adjacent normal tissues (P<0.001), and CIMP+ was associated with advanced stage (P=0.017), lymphatic metastasis (P=0.001) and adverse 2-year progression-free survival (P=0.027). The nine genes validated in tissues also showed a significantly higher frequency of tumor-specific hypermethylation in NSCLC plasma, as compared with the cancer-free plasmas, and a 5-gene set (APC, RASSF1A, CDH13, KLK10 and DLEC1) achieved a sensitivity of 83.64% and a specificity of 74.0% for cancer diagnosis. Thus, the results indicated that methylated alteration of multiple genes plays an important role in NSCLC pathogenesis and a panel of candidate epigenetic biomarkers for NSCLC detection in the Chinese population was identified. © 2010 Elsevier Ireland Ltd.
MicroRNAs as potential biomarkers in human solid tumorsJun Shen | Sanford A. Stass | Feng Jiang
Volume 329, Issue 2, February 2013, Pages 125-136
MicroRNAs (miRNAs) regulate the expression of approximately 30% of protein-coding genes. Functions of miRNAs are essential to maintain a steady state of cellular machinery. Dysregulations of miRNAs play pivotal roles in the initiation and progression of malignancies. Abnormal miRNA expressions have been found in a variety of human solid tumors. Furthermore, extracellular miRNAs could circulate in body fluids, and hence show great promise for refining diagnosis and prognosis of cancer. Here we review the progress of analysis of microRNAs as a potential approach for diagnosis and prognosis of solid cancer. We will also discuss obstacles in developing miRNAs as circulating biomarkers. © 2012 Elsevier Ireland Ltd.
MTOR inhibitors in cancer therapyYekaterina Y. Zaytseva | Joseph D. Valentino | Pat Gulhati | B. Mark Evers
Volume 319, Issue 1, June 2012, Pages 1-7
The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling makes it an attractive target for therapeutic intervention and has driven the development of a number of mTOR inhibitors. Encouraging data from preclinical studies have resulted in initiation of multiple clinical trials. Furthermore, combinational strategies are being studied in an effort to overcome resistance and enhance efficacy. Although additional studies are required to determine their specific role in the clinical setting, mTOR inhibitors remain a promising therapeutic option for the treatment of cancer. © 2012 Elsevier Ireland Ltd.
Galectin-3 - A jack-of-all-trades in cancerAnna U. Newlaczyl | Lu Gang Yu
Volume 313, Issue 2, December 2011, Pages 123-128
Galectin-3 is a mammalian β-galactoside-binding protein that is expressed by various types of human cells. Changes in galectin-3 expression and subcellular and intercellular localizations are commonly seen in cancer and pre-cancerous conditions. It is increasingly recognized that galectin-3 is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell growth, transformation, apoptosis, angiogenesis, adhesion, invasion and metastasis. Such a divergent influence of galectin-3 on cancer cell activities derives from its multiple inter- and sub-cellular localizations where it interacts with a range of different binding partners. This mini-review summaries the diverse influences of galectin-3 on cancer cell behaviours with particular emphasis on its role in tumorigenesis and metastasis. © 2011 Elsevier Ireland Ltd.
P38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agentsXinbing Sui | Na Kong | Li Ye | Weidong Han | Jichun Zhou | Qin Zhang | Chao He | Hongming Pan
Volume 344, Issue 2, March 2014, Pages 174-179
The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit extracellular signals to regulate cell growth, proliferation, differentiation, migration, apoptosis and so on. Apoptosis as well as macroautophagy (hereafter referred to as autophagy) can be induced by extracellular stimuli such the treatment of chemotherapeutic agents, resulting in different cell response to these drugs. However, the molecular mechanisms mediating these two cellular processes remain largely unknown. Recently, several studies provide new insights into p38 and JNK MAPK pathways function in the control of the balance of autophagy and apoptosis in response to genotoxic stress. Our increased understanding of the role of p38 and JNK MAPK pathways in regulating the balance of autophagy and apoptosis will hopefully provide prospective strategies for cancer therapy. © 2013 Elsevier Ireland Ltd.
Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locationsWoody Han | Hui Wen Lo
Volume 318, Issue 2, May 2012, Pages 124-134
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated molecular pathways in human cancers. Despite its well-established importance in tumor growth, progression and drug-resistant phenotype over the past several decades, targeted therapy designed to circumvent EGFR has yielded only modest clinical success in cancer patients, except those with non-small cell lung cancer (NSCLC) carrying EGFR activation mutations. However, almost all of these NSCLC patients eventually developed resistance to small molecule EGFR kinase inhibitors. These disappointing outcomes are, in part, due to the high complexity and the interactive nature of the EGFR signaling network. More recent compelling evidence further indicates that EGFR functionality can be dependent on its subcellular location. In this regard, EGFR undergoes translocation into different organelles where it elicits distinctly different functions than its best known activity as a plasma membrane-bound receptor tyrosine kinase. EGFR can be shuttled into the cell nucleus and mitochondrion upon ligand binding, radiation, EGFR-targeted therapy and other stimuli. Nuclear EGFR behaves as transcriptional regulator, tyrosine kinase, and mediator of other physiological processes. The role of mitochondrial EGFR remains poorly understood but it appears to regulate apoptosis and autophagy. While studies using patient tumors have shown nuclear EGFR to be an indicator for poor clinical outcomes in cancer patients, the impact of mitochondrial EGFR on tumor behavior and patient prognosis remains to be defined. Most recently, several lines of evidence suggest that mislocated EGFR may regulate tumor response to therapy and that plasma membrane-bound EGFR elicits survival signals independent of its kinase activity. In light of these recent progresses and discoveries, we will outline in this minireview an emerging line of research that uncovers and functionally characterizes several novel modes of EGFR signaling that take center stage in the cell nucleus, mitochondrion and other subcellular compartments. We will also discuss the clinical implications of these findings in the rationale design for therapeutic strategy that overcomes tumor drug resistance. © 2012 Elsevier Ireland Ltd.
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivoWei Zhu | Ling Huang | Yahong Li | Xu Zhang | Jianmei Gu | Yongmin Yan | Xiaomeng Xu | Mei Wang | Hui Qian | Wenrong Xu
Volume 315, Issue 1, February 2012, Pages 28-37
Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell-cell interactions may contribute to tumor progression. © 2011 Elsevier Ireland Ltd.
Targeting apoptotic and autophagic pathways for cancer therapeuticsJun jie Liu | Mou Lin | Jia ying Yu | Bo Liu | Jin ku Bao
Volume 300, Issue 2, January 2011, Pages 105-114
Apoptosis and autophagy are genetically regulated, evolutionarily-conserved processes that regulate cell fate; however, apoptosis invariably contributes to cancer cell death, whereas autophagy plays the Janus role of cancer cell survival and death. In this review, we firstly focus on targeting cancer cells via several key apoptotic pathways for anti-cancer therapy. Additionally, we demonstrate that some autophagic pathways play dual roles in cancer, and further elucidate the intricate relationship between apoptosis and autophagy. In summary, these findings may ultimately allow biologists to harness apoptotic and autophagic pathways as novel targets for cancer therapeutics. © 2010 Elsevier Ireland Ltd.
Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer researchAlesia Ivashkevich | Christophe E. Redon | Asako J. Nakamura | Roger F. Martin | Olga A. Martin
Volume 327, Issues 1-2, December 2012, Pages 123-133
Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis for a sensitive assay of DNA damage in human biopsies. The review focuses on the application of γ-H2AX-based methods to translational studies to monitor the clinical response to DNA targeted therapies such as some forms of chemotherapy, external beam radiotherapy, radionuclide therapy or combinations thereof. The escalating attention on radiation biodosimetry has also highlighted the potential of the assay including renewed efforts to assess the radiosensitivity of prospective radiotherapy patients. Finally the γ-H2AX response has been suggested as a basis for an in vivo imaging modality. © 2011 Elsevier Ireland Ltd.
Inhibition of HSP70: A challenging anti-cancer strategyAnastasia R. Goloudina | Oleg N. Demidov | Carmen Garrido
Volume 325, Issue 2, December 2012, Pages 117-124
HSP70 is a chaperone that accumulates in the cells after many different stresses promoting cell survival in response to the adverse conditions. In contrast to normal cells, most cancer cells abundantly express HSP70 at the basal level to resist to various insults at different stages of tumorigenesis and during anti-cancer treatment. This cancer cells addiction for HSP70 is the rational for its targeting in cancer therapy. Much effort has been dedicated in the last years for the active search of HSP70 inhibitors. Additionally, the recent clinical trials on highly promising inhibitors of another stress protein, HSP90, showed compensatory increase in HSP70 levels and raised the question of necessity to combine HSP90 inhibitors with simultaneous inhibition of HSP70. Here we analyzed the recent advancement in creation of novel HSP70 inhibitors and different strategies for their use in anti-cancer therapy. © 2012 Elsevier Ireland Ltd.
Oxidatively induced DNA damage: Mechanisms, repair and diseaseMiral Dizdaroglu
Volume 327, Issues 1-2, December 2012, Pages 26-47
Endogenous and exogenous sources cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and, unless repaired, lead to a variety of mutations and consequently to genetic instability, which is a hallmark of cancer. Oxidatively induced DNA damage is repaired in living cells by different pathways that involve a large number of proteins. Unrepaired and accumulated DNA lesions may lead to disease processes including carcinogenesis. Mutations also occur in DNA repair genes, destabilizing the DNA repair system. A majority of cancer cell lines have somatic mutations in their DNA repair genes. In addition, polymorphisms in these genes constitute a risk factor for cancer. In general, defects in DNA repair are associated with cancer. Numerous DNA repair enzymes exist that possess different, but sometimes overlapping substrate specificities for removal of oxidatively induced DNA lesions. In addition to the role of DNA repair in carcinogenesis, recent evidence suggests that some types of tumors possess increased DNA repair capacity that may lead to therapy resistance. DNA repair pathways are drug targets to develop DNA repair inhibitors to increase the efficacy of cancer therapy. Oxidatively induced DNA lesions and DNA repair proteins may serve as potential biomarkers for early detection, cancer risk assessment, prognosis and for monitoring therapy. Taken together, a large body of accumulated evidence suggests that oxidatively induced DNA damage and its repair are important factors in the development of human cancers. Thus this field deserves more research to contribute to the development of cancer biomarkers, DNA repair inhibitors and treatment approaches to better understand and fight cancer. © 2012.
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancerParthasarathy Seshacharyulu | Poomy Pandey | Kaustubh Datta | Surinder K. Batra
Volume 335, Issue 1, July 2013, Pages 9-18
Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules like Akt, p53, c-Myc and β-catenin. It plays a critical role in cellular processes, such as cell proliferation, signal transduction and apoptosis. Structurally, it is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. PP2A undergoes post-translational modifications (i.e. phosphorylation and methylation), which in turn, regulates its enzymatic activity. Aberrant expression, mutations and somatic alterations of the PP2A scaffold and regulatory subunits have been observed in various human malignancies, including lung, breast, skin and colon cancer, highlighting its role as a 'tumor suppressor'. This review is focused on the structural complexity of serine/threonine phosphatase PP2A and summarizes its expression pattern in cancer. Additionally, the PP2A interacting and regulatory proteins and substrates are also discussed. Finally, the mouse models developed to understand the biological role of PP2A subunits in an in vivo model system are also reviewed in this article. © 2013 Elsevier Ireland Ltd.


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You are hereHome › Hospital Services ›
Cardiac Care Institute at Desert Springs Hospital
Desert Springs Hospital Medical Center, often referred to as "The Heart Hospital" by longtime area residents, has established a solid reputation for being a leader in cardiac care in southern Nevada. Our innovative approach to the diagnosis and treatment of chest pain through the Chest Pain Observation Unit leads to efficient care for our cardiac patients and is nationally recognized by the Society of Chest Pain Centers. This efficient, quality care has earned Desert Springs Hospital Medical Center a ranking as one of "America's Top 100 Hospitals for Interventional Cardiology Services," according to HCIA, Inc.
Our heart failure program is the first in Nevada to be certified by The Joint Commission.
Desert Springs Hospital Medical Center's complete cardiovascular services include a cardio-pulmonary laboratory, three catheterization labs, tilt table technology, cardiac surgery, inpatient cardiac rehabilitation and the Cardiac Progressive Care Unit — a dedicated care unit for cardiac patients.
Chest Pain Center
The Chest Pain Observation Unit at Desert Springs Hospital was the first in Nevada to be nationally recognized by the Society of Cardiovascular Patient Care for meeting or exceeding national care standards for acute cardiac medicine.
The Society of Cardiovascular Patient Care's goal is to reduce mortality from heart attacks by teaching the public to recognize and react to the early symptoms of a heart attack and to reduce the time that it takes to receive treatment.


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The 25.5mm Metal Screw-In Lens Cap from General Brand is a spare or replacement lens cap to fit any lens with a 25.5mm filter thread. The metal construction of this lens cap provides maximum protection against scratches, fingerprints and the elements when not in use.


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Sight Words Teacher Resources
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Mastering basic sight words is one of the first steps your pupils can take toward learning how to read. Promote reading fluency by practicing basic sight words with the interactive activities included here. Kids will enjoy the bright...
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Spelling Practice Sight Words 3
Elementary learners complete the sentence frames by writing in the missing word. Each of the ten sentence frames provided is missing a word that appears in the word bank located at the top of the page. Each blank is also divided into the...
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Learners read short stories containing Dolch sight words and describe the scenes and answer comprehension questions. After relating the stories to their own experiences or observations, they draw pictures illustrating a scene from the...
K - 2nd English Language Arts


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Lenny Kravitz on 'Catching Fire': Cinna lets out his inner-Lenny Kravitz
SAN DIEGO - If you see Lenny Kravitz, you can't help but to want to talk about his suave fashion and style. The singer and actor opened up about his costumes for "The Hunger Games: Catching Fire" as he returns to the role of Cinna. And it sounds like Cinna is a lot more like Lenny Kravitz, as far as the "look" goes.
"The clothing this time was more in line with how I dress," he told HitFix during Comic-Con. "I felt like I was wearing my own things throughout the film."
Check out what else the rocker had to say about the sequel, on costume designer Trish Summerville's "beautiful things."
"Catching Fire" heads to theaters on Nov. 22.
Watch HitFix's interview with Jennifer Lawrence.
Watch HitFix's interview with Josh Hutcherson.
Watch HitFix's interview with Jena Malone.


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In an offseason short on big moves, the Golden State Warriors emerged at the front of the pack. Be it signing a big name like Andre Iguodala, washing their hands of unpalatable contracts or simply being fortunate enough to be saved from themselves (here's looking at you, Dwight Howard), it was their strongest in years.
With the team coming off one of the most surprising playoff runs in recent memory, it's no surprise that they felt the need to go out and make a splash.
Winning time is now.
The Warriors, who have seemed to be in a perpetual state of "rebuilding" over the last 20 years, used this offseason to decree that the future is no longer the answer to the question of their relevancy.
Let's take a look at some of the offseason moves and free-agency acquisitions the Warriors made to push themselves out of the realm of pretenders, and firmly entrench themselves in the prestigious club of contenders.
Here are the five most important moves, in ascending order, made by the Warriors.


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A Zulu Farewell
... thing that I have learned in Africa is that while white people have the watches the Africans have the time. Things have a rhythm of their own here and things take as much time as it takes. I have to confess to a little impatience but it is always best to let people move at their own pace and that has been the case in this instance. While being busy getting things ready for the trip and also building single track for the annual "Ratt Race" with a small ...
A fun day
... We watched an eagle, an owl and a falcon perform and when the eagle was in the air he was chased by a native crow and soon came flying home to get out of the crow's way. A very entertaining morning. We then headed on to the Canopy Tour where we were kitted up with harnesses and helmets. I was somewhat concerned that it would be too scary for Derek. Fortunately there were only two of us on our tour along with our two young guides, Promise and ...
Durban - A City of Parks and Gardens
Durban and its surrounding areas are full of wonderful gardens and parks, all well worth a visit by nature loving people. One of Durban's oldest public institutions is the Botanical Gardens.� It is also Africa's oldest surviving botanical garden. Established in 1849, the gardens were established to participate in London's Kew Gardens quest to establish botanical gardens across the world.� These gardens were set up to ...
Testing The Tour
... children to return - it will be our turn soon.The river is calling. It beckons us with is cool arms to enter and experience it's adventurous, free spirit, as we ride its rapids on a tube and live the adventure. It has begun!
Just two hours west of our base camp in the leafy suburb of Cowies Hill rise the mighty uKhahlamba Drakensberg mountains. The Zulu name means "barrier of spears" as their majestic peaks stab proudly into the vast blue skies ...
Back in Africa
... flowing across the concrete causeway carrying tree branches, large tufts of grass and other assorted flotsam. Although I had been told that Isibindi means courage, deciding to drive into this torrent would not be a show of courage but stupidity. We placed a rock at the waters edge and after ten minutes saw that there was a gradual falling of the water, just have to wait it out. We could talk to the driver on the other side by cell phone, a remarkable event in ...


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by M. Malone
The Alexanders by M. Malone (Book 1)
- #1035 in Romance, Romantic Suspense
- #3289 in Romance, Contemporary
- #332 in Kids, Teen, Love and Romance
- Free eBook
From NYT Bestselling author M. MALONE, comes a heartbreakingly sexy new story about second chances...
Death took everything from him.
Jackson Alexander was born with the voice of an angel and his only dream was to "make it". But his devotion to his music meant he was too busy working to protect his wife. After her death, he made a promise to himself.
He'd never sing again.
Ridley Wells has a habit of picking the wrong men but she's never ended up on the radar of a Mafia don before. Hiding out with her twin sister makes the most sense except she never thought her sister would be halfway around the world. Or that she'd be mistaken for her sister by the sexiest man she has ever seen.
There's a dark, broken spirit inside of Jackson that she knows she can heal. But the depth of her lies threatens the trust between them until Ri has to make a choice.
Trust him or break him all over again.
"No. Stay." Those two simple words halted her in her tracks. He smiled a slow, sexy grin before pulling open the second drawer in his bureau. He rummaged for a while, pulling out shirts and then pushing them back in. "I'm trying to find one of my shorter ones so it won't swallow you up."
"Oh, I like them longer. It'll hang lower and cover my legs like a nightgown."
He stopped digging and glanced at her. Then his eyes dipped lower to take in her bare legs exposed by the mid-thigh, terry-cloth shorts she wore. "Right."
He held out a shirt and Ridley took it carefully, making sure their fingers didn't touch.
"Well, thanks again. Good night." She fled the room, racing down the darkened hallway, not stopping until she reached the door of the guest room. She turned the handle and opened the door, but before she entered she looked back.
She had to.
Jackson stood in the same position next to his dresser. The heat of his gaze burned over her entire body and she shivered as her nipples peaked against her shirt. She didn't know him well enough to interpret the look on his face but she could interpret her body's response.
God, she wanted him.
He'd been nothing but a gentleman all day, seeing to her every need, listening to her vent and keeping her company. He hadn't made any moves on her, hadn't done anything suggestive or said anything provocative. Was he just being a good host and making sure she made it to her room?
Or was he imagining what she would look like when she stripped off her clothes and went to bed wearing nothing but his shirt?
~ Download your copy and start reading ONE MORE DAY now! ~
READERS ARE LOVING "One More Day"
Ms. Malone has created a family that anyone would like to claim as their own, and the romance is wonderful. The romance was real, I fell in love with all the Alexander family, and boy are the "boys" hot.
~Amazon reviewer
This book was awesome!! I felt excited, sad, aroused (tee-hee) and so much love!! Spoiler Alert:I love when he sang his song to her at studio. That was one of my loved moments. I'm hoping there's a story for Nick & Raina... Looking forward to the The Alexander Series!
~B&N reviewer
omg! loved this book...had me in tears of all kinds...had me in laughter of all kinds! Jackson is ... wow! and so are the rest of the Alexander clan :D
~Goodreads reviewer
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Couldn't put the book down after reading the free prequel. Worth every penny! Can't wait to read next books in series.by Christina on July 17, 2013
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I can't wait for more!
This is an example of how meddling ruins a great thing..well almost..but it also proves that true love indeed conquers it all. Not blaming anyone. It's family after all. This book was beautifully written. It will teach you that before anyone else, you should listen to the person you love. The romance was very eminent. The plot was wonderfully placed and all the characters were significant. There were no bystanders as everyone contributed to the whole effect of the book. I got this one for free and I'm getting every book in this series.by ilovexpassion on July 29, 2014
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Entertaining easy reading, with good descriptions and plot. You also like the characters, which keeps you interested .by SJ on October 15, 2016
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Very good book can't wait to read the next oneby Natalie on August 10, 2013
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I enjoyed this read very much! What more can I say! Relax and enjoy the read!!!!!by Rachel on December 10, 2014
One More Day (A Sexy Standalone Contemporary Romance)
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The Alexanders by M. Malone (Book 1)
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by on October 23, 2016
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• Aluminum
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Dr. Darin Iha specializes in periodontology in Honolulu, Hawaii.
Dr. Darin Iha has been compared 45 times. Details of Dr. Iha's experience as an DDS are available on your free dentist report.
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- LOIS HENRY: Sheriff's helicopter safety shouldn't be left up to luck
- Visibility was diminished partly because the pilot also neglected to turn on the demister, allowing the windshield to fog on the inside, something that was known to happen in the rain.
- Tackling The Wet Days
- Amidst the sudden change in weather, rains took us by surprise in the week gone by, and the entire country ran into chaos, with blocked roads and clogged wadis.
- LDI to ZDI+: Exploring the Maruti Suzuki Vitara Brezza
- They also get a rear wiper and washer, along with a demister. Steering mounted controls, mood lights in the speedometer, climate control and a height adjustable driver seat are only present in the ZDI variant.
- Mobile Marketing Isn't Just For Apple Devices
- Did you know that you can't switch on the rear window demister on a Tesla Model S remotely from your key fob, nor from your phone? Of course you didn't – you'd never know unless you'd spent some time with one. If even a small part of your business is ...
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