text:
Rating: 5 stars 14 14 reviews
601 Commonwealth Place, Building C Pittsburgh PA 15222 USA
Our mission is to operate and maintain the Fort Pitt Block House as a historial site and museum, to maintain the surrounding grounds and to promote preservation, education, and public awareness of Pittsburgh's role in early American history.
2014 marks the 250th anniversary of the construction of the Fort Pitt Block House, our goals for this year are: - To utilize the celebration of Block House 250 to increase awareness in the community about the Block House and Pittsburgh's role in early American history. - To raise the funding needed to continue to operate the Fort Pitt Block House as a museum and historic site that is free and open to the public. Much of our activities and accomplishments in the past year focused on the planning and preparations for Block House 250: - A comprehensive restoration and preservation project was completed on the 250 year old structure to ensure it continues to stand for future generations. Funding for the project was provided through generous support from an anonymous donor and the Colcom Foundation; - The grounds of the Fort Pitt Block House received a much needed makeover highlighted by the Edith Ammon Memorial Garden. The garden was designed with two goals in mind: to create an attractive and welcoming outdoor space for visitors and to pay tribute to Edith Darlington Ammon and the other founding members of the Fort Pitt Society who were instrumental in saving the Block House from demolition in the early 20th century. Funding for the garden was provided by foundation and corporate support and the proceeds generated by the sale of fundraising bricks; - 2013 brought a record number of visitors to the Block House. 60,708, an incredible 67% increase over the previous year. About 20,000 of those visitors came during the four week stay of the giant rubber duck brought to Pittsburgh as part of the Pittsburgh Cultural Trust's International Festival of Firsts. - Block House Curator, Emily Weaver, published the first comprehensive history of the Fort Pitt Block House. The book is sold in local bookstores, online and at the Block House. Emily does educational presentations about Block House history at local libraries and retirement communities as well as for other nearby historic sites and societies.
Target demographics:
Everyone interested in American and British history, historic preservation, the history of Pittsburgh, the French and Indian War, and the American Revolution
Direct beneficiaries per year:
more than 60,000 visitors
Geographic areas served:
All residents of Pittsburgh, the surrounding region, the Commonwealth of Pennsylvania, United States as well as international visitors
The Fort Pitt Block House offers public as well as private guided tours, highlighting the building's construction, history, preservation, and its cultural significance. Curator available to provide lectures about the Fort Pitt Block House and its history to interested groups and schools.
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Reviews for Fort Pitt Block House
Although small, the Fort Pitt Block House is one of the most important, if not the most important historical structure in Western Pennsylvania. As Pittsburgh's oldest building (1764) it has stood witness to the city's transformation from wilderness outpost, to industrial giant, to "green" innovator, and the extremely knowledgeable staff can share stories from each of these eras. Although originally a military building, the Block House's most fascinating stories come from the post-military period, illustrating how the building and it's residents adapted to the changing face of the city and local environment. ADMISSION IS FREE, SO NO VISITOR TO DOWNTOWN PITTSBURGH SHOULD MISS THIS REMARKABLE GEM!
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text:
8 Parks near Edwards AFB, California
Edwards Air Force Base, California 0.82 miles SE
North Edwards, California 9.19 miles NE
Rosamond, California 12.9 miles SW
Mojave, California 14.8 miles NW
California City, California 15.93 miles NW
Edwards AFB, California (map) | (661) 275-2267
Sites: 51 | Latest Rate: $5.00 | 8 Reviews
|Clean Restrooms:
|Clean Showers:
Dec 2014 - $5.00
Stayed here on the overflow sites for three nights. Full park due to military base construction workers. Full price is 17., overflow is 5. Used the restrooms, laundry, day room, dump station and was able to refill water tanks. - washingtoncolorado
Dec 2013 - $15.00
We stayed at the campground for a week prior to Christmas. There were plenty of sites available at that time. Sites are relatively level, only requiring a couple of blocks. There is a check in board at the entrance of the park where you place your money in the locked box and registration card on the back of the board. I had contact with the camp host prior to our arrival checking on availability however never saw him during our stay. The Wi-Fi was down when we got there and it took about four days before we got it back up. There is no cable and no TV signal. There was a Direct TV in the lounge however that was down as well throughout our stay. BX, commissary, and service station were open except for Christmas. Most other base functions to include the club were down. A decent place to stay. - ownedafew
Oct 2013 - $17.00
The base is very easy to get to from Hwy 58. You will go under a train trestle just off of Hwy 58, the height sign says its 14'. The park is very clean and the camp host very welcoming. You share the hook-up area with the neighboring site which makes the driver's side slide outs of your RV inches from your neighbors. We used 2 electrical cords due to the length from the back of our rig to the electrical box. There are 2 roads inside the park, a perimeter road and an interior ring so rigs can pull in from either direction. Parking of your TV or toad should NOT protrude onto the perimeter/interior roadway. There was an individual in a Class A who parked his toad in front of his rig on the interior road, while we were there, which impeded our ability to stay on the roadway. We enjoyed our stay and will return. - MAFLAF
Mojave, California (map) | (661) 824-2811
Sites: 50 | Latest Rate: $1.00 | 11 Reviews
|Clean Restrooms:
|Clean Showers:
Jun 2015 - $1.00
Pulled into this "park", looked around at the lack of amenities, shade, trees, etc. The only thing there appeared to be an abundance of was blowing sand and wind. The few units in the "park" appeared to have been there for a very extended time. Needless to say we did not stay. - sandstorm
Jun 2013 - $20.00
We stayed here 2 nights. There isn't anywhere else to stay. It isn't an RV park; most sites are RV's, but they are extended stay. It is a run down town, and this park is right in town. It's okay for a night, but there's not much to do. There is a coffee shop not far from the park which is very nice. It serves great coffee and other drinks, has fresh donuts and serves sandwiches, too. - bonne1
Mar 2013 - $25.00
There are a lot of permanent residents in the park and some very run down trailers, so don't expect a beautiful park. It worked for us as an overnight while passing through and was nice and quiet at night. It felt fairly safe since one of the residents was a sheriff's deputy. The lady manager was very nice and accommodating. The service is 30 amp but seemed to be strong service. We did not have reservations, but there were lots of open spaces. We did not have a problem with satellite since there are no trees. Our Verizon phone and data card worked well. The prior reviewers have pointed out the things to do in town, so I will not go into them. There is a surprisingly good food market in town. As noted, do expect wind. We would stay here again if passing through, but only for a night on the way. - TheJim
Mojave, California (map) | (760) 373-4950
Sites: 72 | Latest Rate: $36.00 | 59 Reviews
|Clean Restrooms:
|Clean Showers:
Jul 2016 - $36.00
There were two reasons why we gave the park a low rating. The WiFi was based on satellite service so it was slow and spotty. In desperation to check out e-mail we stood under the router to connect and had to type standing up. The advertised pool was there and full of water but the water was green and the gate was padlocked. I have never seen a dirtier pool.
The owner was very friendly, but we felt the Park was not a good value for the price.
We were able to use our satellite and pick up TV. - WNC Traveler
May 2016 - $22.00
A nice park, with friendly staff. Every site has a picnic table and charcoal grill. All sites that have access to WiFi are back-in. There are some pull-throughs, but they are out of WiFi range. Close to Hwy 14, and about 15 miles from Red Rock Canyon State Park (worth seeing). - ta96silver
Apr 2016 - $20.00
Friendly staff, and for an overnight stay, a pull-through no less. It fit the bill and worked for us. The site was sunny with some shade, No, it is not the Taj Mahal, but neither is the price. If back this way, we WILL stay again. - Len C
12401 Boron Ave # 18 Boron, California 93516 (map) | (760) 762-5008
Sites: 30 | Latest Rate: $22.00 | 34 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2016 - $22.00
Older park, but all we saw was in good repair. Sites were well spaced - many have shade at various times of day. Electric-water-sewer all good - 121 volts on each leg of 50A w both A/C's running. Level sites. Not much to do here except relax after a long day on the road - exactly our liking. Quarter mile south of Rt58 - eastern-most exit for Boron - easy on/off. We'd stay here again if thru this area. Nice folks, too. - jtids
Jun 2016 - $14.00
Old style park, but full hookups with 50 amp service. No cable, and wifi is available but weak as you get further from office. Great value for money. Passport America good for one night only. - grunt50
May 2016 - $14.00
Level gravel pull thru with full h/ups. Good WiFi, cell and satellite service. P/A discount was $14. Odd shower set up - 2 stalls and 2 side by side toilets all in 1 room. Co-ed but you can lock from the inside. Great water pressure. Only stayed overnight in a 37' RV with tow which we did not have to disconnect. - julesverne
2551 W Avenue H Lancaster, California 93536 (map) | (661) 206-0427
Sites: 84 | Latest Rate: $25.00 | 28 Reviews
|Clean Restrooms:
|Clean Showers:
Jul 2016 - $25.00
This is a concrete lot on the north side of the Antelope Valley Fairgrounds with full hookups and 50 amp power for $25/night. We stayed here one night as a stopover on a trip. There are no services here other than hookups. The rv slots are painted lines on the ground.
If you are attending an event at the Fairgrounds, it is an ideal location. If there is no fairgrounds event, as for our night, this camp is quiet and isolated.
There were many longer term residents during our stay, working on the new solar panel farms outside of town according to our neighbor.
The camping slots are wide and easy to access. The power voltage was consistent as the water pressure. Be sure to check in with the RV park manager since they do take reservations. That wasn't clear to us when we used the self service check-in. We later saw it in their printed rules.
We didn't use the bathrooms or showers as we stayed in our unit. There was a consistent 20 knot west wind all night long so nobody was using awnings.
Basic services for a reasonable price. - Gaucho Mac
Mar 2015 - $20.00
This is a great place for what it is - a paved parking lot in the Mojave Desert. Given that it is in Lancaster and most people don't have any reason to come to Lancaster, it is a very good place to stay for a few nights depending on your reason for being in the area.
The bathrooms are extremely clean - free showers - full hookups - very cheap rate $20 a night. It is very clean and quiet - except you can hear the freeway because in the desert sound travels a long ways.
The WiFi is very good and free. The manager is very nice. If you want to pay by credit card you have to wait until she is around - but that was no big deal. Very few channels for TV on the antenna. Satellite signal very good.
Very large level sites - with both pull through and back in. Any size rig could stay here. - NiMo
Jan 2015 - $25.00
My wife and I have stayed at the Antelope Valley Fairgrounds RV Park several times in the past because of its location close to where our boys live in Lancaster. The park is large enough that reservations usually are not needed. It has no trees, grass, club houses, pools, pet areas (except for the desert across the street) it also has no laundry facilities or cable. It is a bare minimum city run park with no RV club discounts. It does however have large restroom and showers that are usually clean and in working order that are taken care of by a cleaning crew. The park is all asphalt and it has fairly wide spaces for pull thru's and back end parking. It has a great Verizon signal and easy for RV's of any size to maneuver. It is freeway close.
As for the cons. Read the park rules posted on the wall when you arrive and do the self serve check in and then just flush the rules out of your mind because there is no one who enforces these rules once you clear the front gates. While we know the park is located next to the Fairgrounds we do expect to hear loud speakers during the day if there is an event going on. You may hear a concert till 2am on the weekend. There is also an off road motocross track next door that you will hear loud motorcycles and a PA on Friday to Sunday from 8am to 4PM. We can deal with that but, the go carts, dirt bikes, motorized skateboards and dogs running lose in the park itself should not be expected at an RV park especially run by the city. There is one manager on site and she does nothing but look after her flowers at her RV and just collect the money from the box. If you call her on the list ph. # if will go to voice mail. She does nothing if you ask her in person to do her job as a manager and advise the violators to stop. I know from experience from my past profession that talking to people who ride these loud toys or let their dogs run loose that it only brings anger, animosity and retaliation even if you politely ask someone to stop. You have to keep one eye open so they don't vandalize your property. I have seen this happen to other nice people who just try to ask others to do the same. While I ride a Harley I don't start it until I am ready to leave and I don't make excessive noise to let the world know what I ride. Others don't get that you're not the only person in the world. One more reason why we left Calif.
This park is just conveniently close to our boys and that is why we stay here. If your looking for a really nice park in the Antelope Valley (Lancaster/Palmdale) area then you might want to check out parks in Acton. - SteelHorseRider
Lancaster, California (map) | (661) 942-1625
Sites: 43 | Latest Rate: $15.00 | 5 Reviews
|Clean Restrooms:
|Clean Showers:
Nov 2015 - $15.00
No frills is a good way to describe this place. The sites are reasonably sized and can easily accommodate the largest rigs. The location is OK for a stopover but it's not near anything interesting. The 30 amp at our pedestal (#39) did not work, but since we didn't need AC we just used the 20 amp circuit. The wifi and cable TV didn't work. The dump station was closed for some concrete repair. We would come here again for an overnight stopover. - User3589
Jan 2014 - $8.00
Overall, this is a nice no-frills campground located behind the Elks lodge, which is on a busy avenue. We stayed over in the dry camping area (the gravel parking area just west of the lodge) for one night without any hookups, so I can't comment on the quality of them. Train traffic can be heard off in the distance, and during the day, road noise from the street in front of the lodge. Current suggested donations are $8 for dry camping and $18 for the partial hookups. There's lots of room to maneuver big rigs and plenty if space to walk your pets. The camp host was friendly, as we're all the Elk members we met in the lodge. They made us feel like family. We'll definitely stay here again when passing through or when visiting the area longer. - Gyropilot
Nov 2010 - $15.00
We stay here every year when we come to Lancaster to visit with family. This is for Elk members and their guests only. They have lowered the price from $17 to $15 per night. We will stay here again when we come through Lancaster. The Elks is close to almost everything you could need or want. - kathiecarlson
California City, California (map) | (760) 373-8617
Sites: 20 | Latest Rate: $35.00 | 3 Reviews
|Clean Restrooms:
|Clean Showers:
Sep 2014 - $35.00
What we liked most about Silver Saddle Ranch was the peace and quiet. It is a large resort acreage so there was plenty of room to get away from the central complex. The park is also located about 12 miles from town which really gives a sense of being away from it all. Nice ponds, landscaping and lots of trees added to the country feel. On the down side...the central complex closes mid week so be prepared for that. And, on weekends they have a LOT of families come up to visit so it gets busy. Not much in the way of on-site RV services so come prepared. Otherwise, a very nice spot to spend a week. - MtnMutt
Feb 2014 - $25.00
Very quiet during February but beautiful. Resort has small lake surrounded by park setting. The pool was not open (too cold) but the hot tub was (loved it!). Restaurant open just on weekends but that was fine with us. Come stocked as California City is 20 minute drive by car. - MtnMutt
Apr 2006 - $60.00
This is a membership resort that allows use by non-members at higher prices. Beautifully landscaped throughout with many top-notch activities/amenities such as horseback riding, swimming, mini-golf, and a bartender who mixes great cocktails. I would have given a 10, but the sewer backed up on me. When I informed the front desk of this, I was told the same thing happened at the same site last week. They should have fixed it last week! - morganhillers
2705 E Avenue Q, Palmdale, CA 93550 Lancaster, California 93550 (map) | (661) 947-2027
Sites: 50 | Latest Rate: $20.00 | 1 Reviews
|Clean Restrooms:
|Clean Showers:
Nov 2014 - $20.00
Note: For Elks member use only. This is an older Elks lodge, but overall their RV park is nothing fancy but serviceable. There are approximately 21 pull-through sites, most of which should be able to accommodate a total length of about 60 feet. I think 14 of the pull-through sites have concrete pads to park on, with the rest of the RV park being gravel. Most of the pull-throughs have bi-directional hookups (pull in either way). In addition to the pull-through sites, there are plenty of back-in and parallel parking sites. I can't imagine this park ever being completely full. There are no full-hookup sites but a sewer dump is located on site. During our stay the voltage was good and water pressure was 80 psi. Both Verizon and AT&T had weak but usable LTE signals. Upon arrival, register with the friendly and helpful campground host, who's site is marked. We'll definitely stay here again. - Gyropilot

subset: commoncrawl


text:
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Mystic Sciences >> Astrology
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text:
|Systematic (IUPAC) name
5-(4-chlorophenyl)-6-ethyl- 2,4-pyrimidinediamine
|Clinical data
|Trade names
|Routes of
|Legal status
|Legal status
|Pharmacokinetic data
|Protein binding
|Biological half-life
|96 hours
|CAS Number
|ATC code
QP51AX51 (WHO) (combinations)
|PDB ligand ID
|CP6 (PDBe, RCSB PDB)
|Chemical data
|Molar mass
|248.71 g/mol
Pyrimethamine (trade name Daraprim) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and to treat Toxoplasma gondii infections, particularly when combined with the sulfonamide antibiotic sulfadiazine when treating HIV-positive individuals. It works by inhibiting folic acid metabolism via dihydrofolate reductase.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.[1]
Medical uses[edit]
Pyrimethamine is typically given with a sulfonamide and folinic acid:[2]
- Sulfonamides inhibit dihydropteroate synthetase, an enzyme that participates in folic acid synthesis from para-aminobenzoic acid. Hence, sulfonamides work synergistically with pyrimethamine by blocking a different enzyme needed for folic acid synthesis.
- Folinic acid (leucovorin) is a folic acid derivative converted to tetrahydrofolate, the primary active form of folic acid, in vivo without relying on dihydrofolate reductase. Folinic acid reduces side effects related to folate deficiency in the patient.
It is primarily active against Plasmodium falciparum, but also against Plasmodium vivax.[3] Due to the emergence of pyrimethamine-resistant strains of P. falciparum, pyrimethamine alone is seldom used now. In combination with a long-acting sulfonamide such as sulfadiazine, it is widely used, such as in Fansidar though resistance to this combination is increasing.[3] It has been used in the treatment of actinomycosis and isosporiasis, and for the treatment and prevention of Pneumocystis jirovecii pneumonia.[citation needed]
In 2011, researchers discovered that pyrimethamine can increase β-hexosaminidase activity, thus potentially slowing down the progression of late-onset Tay–Sachs disease.[4] It is being evaluated in clinical trials as a treatment for amyotrophic lateral sclerosis.[5]
Mechanism of resistance[edit]
Resistance to pyrimethamine is widespread. Mutations in the malarial gene for dihydrofolate reductase may reduce its effectiveness.[6] These mutations decrease the binding affinity between pyrimethamine and dihydrofolate reductase via loss of hydrogen bonds and steric interactions.[7]
Side effects[edit]
Pyrimethamine can cause a rash, and if higher doses are used (such as for toxoplasmosis), it can cause gastrointestinal symptoms such as nausea, vomiting, abdominal cramps, dry mouth, weight loss, and diarrhea. Central nervous system effects include headache, ataxia, and rarely seizures and haematologic side effects such as leucopenia and anaemia.[2]
Pyrimethamine is contraindicated in patients with:[2]
- Folate-deficiency anaemia
- Epilepsy
- Pregnancy, especially during the first trimester, due to the possible detrimental effects an antifolate such as pyrimethamine might have on organogenesis
Other antifolate agents such as methotrexate and trimethoprim may potentiate the antifolate actions of pyrimethamine, leading to potential folate deficiency, anaemia, and other blood dyscrasias.[2]
It is a white, colourless, crystalline powder; it is practically insoluble in water and slightly soluble in ethanol, chloroform, and acetone.[3] It is unstable in the presence of air and light.[3] It is chemically a diaminopyrimidine derivative.[3]
Mechanism of action[edit]
Pyrimethamine interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).[8] Tetrahydrofolic acid is needed for DNA and RNA synthesis in many species, including protozoa.[8] It has also been found to reduce the expression of SOD1, a key protein involved in amyotrophic lateral sclerosis.[9][10]
The Nobel Prize-winning American scientist Gertrude Elion developed the drug at Burroughs-Wellcome (now part of GlaxoSmithKline) to combat malaria.[11] Pyrimethamine has been available since 1953,[12] and is not subject to any unexpired patent.[13] However, in the United States, the market for this product is sufficiently small that no generic manufacturer has emerged. In 2010, GlaxoSmithKline sold the marketing rights for Daraprim to CorePharma. Impax Laboratories sought to buy CorePharma in 2014, and completed the acquisition, including Daraprim, in March 2015.[14] In August 2015, the rights were bought by Turing Pharmaceuticals.[15] Turing subsequently became known for a price hike controversy when it raised the price of a dose of the drug in the U.S. market from US$13.5 to US$750, a 5,500% increase.[16]
Availability and price[edit]
In the United States, as of 2015, with Turing Pharmaceuticals' acquisition of the US marketing rights for Daraprim tablets,[17] Daraprim has become a single-source and specialty pharmacy item, and the price of Daraprim has been increased.[18] The cost of a monthly course for a person on 75 mg dose rose to about $75,000/month, or $750 per tablet.[19][20] Outpatients can no longer obtain Daraprim from their community pharmacy, but only through a single dispensing pharmacy, Walgreens Specialty Pharmacy, and institutions can no longer order from their general wholesaler, but have to set up an account with the Daraprim Direct program.[18][21] Presentations from Retrophin, a company formerly headed by Martin Shkreli, CEO of Turing, from which Turing acquired the rights to Daraprim, suggest that a closed distribution system could prevent generic competitors from legally obtaining the drugs for the bioequivalence studies required for FDA approval of a generic drug.[21]
Martin Shkreli, CEO of Turing, defended the price hike by saying, "If there was a company that was selling an Aston Martin at the price of a bicycle, and we buy that company and we ask to charge Toyota prices, I don't think that that should be a crime."[22][23] As a result of the backlash, Shkreli hired a crisis public relations firm to help explain his fund's move.[24] Turing Pharmaceuticals announced on November 24, 2015 "that it would not reduce the list price of that drug after all" but they will offer various patient assistance programs.[25] However, New York Times journalist Andrew Pollack noted that these programs "are standard for companies selling extremely high-priced drugs. They enable the patients to get the drug while pushing most of the costs onto insurance companies and taxpayers."[25]
The price increase has been fiercely criticised by physician groups such as HIV Medicine Associates and Infectious Diseases Society of America.[26]
In India, over a dozen pharmaceutical companies manufacture and sell pyrimethamine tablets and, multiple combinations of generic pyrimethamine are available for a price ranging from US$0.04–$0.10 each (3–7 rupees).[27][28][29][30]
In the UK, the same drug is available from GSK at a cost of US$20 (£13) for 30 tablets (approximately $0.66 each).[31]
In Australia, the drug is available in most pharmacists at a cost of US$9.35 (A$12.99) for 50 tablets (approximately US$0.18 each).[32]
In Brazil, the drug is available for R$0.07 a pill, or about US$0.02.[33]
In Canada, the drug was reportedly discontinued in 2013 but hospitals may make the drug in-house when it is needed.[34] As of December 2015[update], Daraprim imported into Canada directly from GSK UK is available from an online pharmacy for US$2.20 per tablet.[35]
On October 22, 2015, Imprimis Pharmaceuticals announced it has made available compounded and customizable formulations of pyrimethamine and leucovorin in oral capsules starting as low as $99.00 for a 100 count bottle in the United States.[36]
See also[edit]
- Etoprine (and metoprine) is closely related structure but has an extra chlorine atom and is instead described as antineoplastic.
- ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ^ a b c d Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
- ^ a b c d e Brayfield, A, ed. (13 December 2013). "Pyrimethamine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 12 April 2014.
- ^ Osher, E; Fattal-Valevski, A; Sagie, L; Urshanski, N; Amir-Levi, Y; Katzburg, S; Peleg, L; Lerman-Sagie, T; Zimran, A; Elstein, D; Navon, R; Stern, N; Valevski, A (March 2011). "Pyrimethamine increases β-hexosaminidase A activity in patients with Late Onset Tay Sachs.". Molecular Genetics and Metabolism. 102 (3): 356–63. doi:10.1016/j.ymgme.2010.11.163. PMID 21185210.
- ^ "Pyrimethamine ALS trial".
- ^ Gatton M.L.; et al. (2004). "Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum". Antimicrob Agents Chemother. 48 (6): 2116–23. doi:10.1128/AAC.48.6.2116-2123.2004. PMC 415611. PMID 15155209.
- ^ Sirichaiwat C, et al. (2004). "Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum". J Med Chem. 47 (2): 345–54. doi:10.1021/jm0303352. PMID 14711307.
- ^ a b "PRODUCT INFORMATION DARAPRIM TABLETS". TGA eBusiness Services. Aspen Pharmacare Australia Pty Ltd. 5 December 2011. p. 1. Retrieved 12 April 2014.
- ^ Limpert, AS; Mattmann, ME; Cosford, ND (2013). "Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)." (PDF). Beilstein Journal of Organic Chemistry. 9: 717–32. doi:10.3762/bjoc.9.82. PMC 3678841. PMID 23766784.
- ^ Lange, DJ; Andersen, PM; Remanan, R; Marklund, S; Benjamin, D (April 2013). "Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: a phase I pilot study.". Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14 (3): 199–204. doi:10.3109/17482968.2012.724074. PMID 22985433.
- ^ Vasudevan, D.M.; Sreekumari, S.; Vaidyanathan, Kannan (2013). Textbook of Biochemistry for Medical Students. JP Medical Ltd. p. 491. ISBN 9789350905302. OCLC 843532694. Retrieved January 15, 2016.
- ^ Ariana Eunjung Cha (2015-09-22). "CEO who raised price of old pill more than $700 calls journalist a 'moron' for asking why". The Washington Post.
- ^ FDA AccessData entry for Pyrimethamine, accessed September 24, 2015
- ^ Pollack, Andrew (20 September 2015). "Drug Goes From $13.50 a Tablet to $750, Overnight". New York Times. Retrieved 17 December 2015.
- ^ John LaMattina (2015-09-21). "Here's A Way For Pharma To Prevent Outrageous Generic Price Increases -- And Help Its Reputation". Forbes.
- ^ Kliff, Sarah (September 22, 2015). "Vox Explainers: A Drug Company Raised a Pill's Price 5,500 Percent Because, in America, It Can". Vox (online). Retrieved December 9, 2015.
- ^ Turing Pharmaceuticals AG Turing Pharmaceuticals AG Acquires U.S. Marketing Rights to DARAPRIM® (pyrimethamine) 10 August 2015, PR Newswire Association LLC
- ^ a b Monica V. Mahoney New Pyrimethamine Dispensing Program: What Pharmacists Should Know PharmacyTimes, July 17, 2015
- ^ ANDREW POLLACK (20 September 2015). "Drug Goes From $13.50 a Tablet to $750, Overnight". Retrieved 21 September 2015.
- ^ "WATCH: Ex-hedge funder who hiked AIDS pill cost by 5,500 percent says drug 'still underpriced'". RawStory.com. Retrieved 22 September 2015.
- ^ a b "The Most Unconscionable Drug Price Hike I Have Yet Seen", by Derek Lowe, September 11, 2014, In the Pipeline.
- ^ Ramsey, Lydia (22 Sep 2015). "A pharma CEO tried to defend his decision to jack up the price of a critical drug by 5,000% — and it backfired". Business Insider.
- ^ Reuters (22 Sep 2015). "Company hikes price of popular drug". Reuters.
- ^ Tannahill, Jason (9 Oct 2015). "PR Man Allan Ripp Representing The "Most Hated Man in America"". EverythingPR.
- ^ a b Pollack, Andrew (24 November 2015). "Turing Refuses to Lower List Price of Toxoplasmosis Drug". New York Times. Retrieved 25 November 2015.
- ^ http://www.hivma.org/uploadedFiles/HIVMA/HomePageContent/PyrimethamineLetterFINAL.pdf
- ^ "MEDLINE INDIA - SULFADOXINE WITH PYRIMETHAMINE". www.medlineindia.com. Retrieved 2015-09-22.
- ^ "It is Cheaper for an American patient to fly out to India and buy a year's supply of the medication than buy a single Daraprim tablet in the US".
- ^ "There is no reason why the United States cannot have as vigorous a market in generic pharmaceuticals as does India".
- ^ "High Drug Prices: Should We Blame Pharma Or The FDA?".
- ^ "What's a fair price for a drug? - BBC News". www.bbc.com. Retrieved 2015-09-23.
- ^ "Chemist Warehouse". www.chemistwarehouse.com.au. Retrieved 2015-12-12.
- ^ "Remédio que teve aumento de 5.000% nos EUA custa R$ 0,07 no Brasil (e não vai aumentar)". brasilpost.com.br. Retrieved 2015-09-23.
- ^ "Turing CEO to roll back 5,000% price hike for Daraprim pills".
- ^ "Daraprim 25mg and/or Equivalents". Retrieved 2015-12-18.
- ^ "Imprimis Pharmaceuticals to Make Compounded and Customizable Formulation of Pyrimethamine and Leucovorin Available for Physicians to Prescribe for their Patients as an Alternative to Daraprim® - Oct 22, 2015". imprimispharma.investorroom.com. Retrieved 2015-10-23.


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Nutritional Information
% Daily Value*
|Serving Size 1 oz.
|Total Fat 0
|0 %
|Servings per 750ml bottle 25
|Sodium 15mg
|1% %
|Calories 0
|Total Carbohydrates 0
|0 %
|Calories from Fat 0
|Sugar 0
|Protein 0
* Percent daily value is based on a 2,000 calorie per day diet.
Purified water, natural flavors, caramel color, sodium benzoate and potassium sorbate (to preserve freshness), citric acid, xanthan gum, sucralose (SPLENDA® Brand), acesulfame potassium.
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Last year, on June 4th, a thunderstorm showed signs of a tornado near Bushland and a tornado warning was issued. The sirens were sounded for the entire city of Amarillo even though the storm stayed well west of town. So it brings up a lot questions, like why can't sirens just in that area be sounded? Why start panic in an area that might not be effected?
We asked Kevin Starbuck, the Emergency Operations Coordinator for Amarillo, to explain tornado siren policy.
"The city of Amarillo, Potter, and Randall County systems is a very large system. They cover everywhere from locations north of the city in Potter county to all the way down south in Umbarger. Because we have a very large system a lot of times we will warn areas that are not necessarily threatened by a severe weather event. Our policy has always been that in the initial stages of severe weather impact that has a rotating wall cloud, funnel cloud, or tornado reported or a National Weather Service warning then we will activate the entire outdoor warning system initially, as time permits and the opportunity becomes available we will try to trim that down to warn specific areas that are being threatened."
In the end, Kevin says it's about keeping people safe when severe weather threatens. It's the goal of city officials and it's also our goal here in the Storm Search 7 Command Center.
So when the sirens go off, seek shelter immediately. And if you can, tune in to Storm Search 7 for latest weather information.


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- Owner
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- The status of this product is "Live"
- Description:
- TIBCO® Enterprise RTView was added to CrunchBase in 2012
Product DetailsUpdate
Enterprise RTView is an open business information delivery platform that is used by IT Managers to rapidly configure, deploy, maintain and extend real-time and other critical enterprise information systems. This enables management and operational personnel to monitor the health and status of business operations. The features of this platform extensively reduce time, cost, and risk associated with developing these systems.
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Welcome to Wikianswers Anime!Edit
Welcome to Wikianswers Anime, Kieronrob. Thanks for contributing! I hope you join in and ask or answer some more questions. You can find the new questions on the WikiActivity page. If you need any help, have a look at Help:Wikianswers. -- Akadirgun (Talk) 00:09, August 31, 2011
Answering Your Own Questions Edit
Please do not ask a question if you already know the answer yourself, which your answering of the tomiyo and sonido/shumpo questions today suggests. It constitutes spamming of this site. Thank you ~~Ууp <talk> 12:10, November 8, 2012 (UTC)
- ^This. Like what you did here. If you continue, I'm going to assume you're edit/achievement boosting, then I'll report you to the admins.--White Flash (Contact) 18:13, January 30, 2013 (UTC)
*facepalm/ If you knew the answer to your question why ask it? Someone is too attached with badges >_> it would seems and I will guarantee you'll be block for it, so go ahead and edit boost make my day.--White Flash (Contact) 19:06, January 30, 2013 (UTC)
Re:Naruto Answers and Fanon Wikis? Edit
I am aware of the existence of both of them. Naruto Answers is going through an overhauling, and I will decide whether I want to enroll myself there when the things cristalize a little bit. Regarding the Fanon Wiki, I think I wouldn't be of much help there.--Vecanoi (talk) 22:32, November 20, 2012 (UTC)
Comments Edit
You better go and ask Jacce about it. Btw, bleach answers doesnot have comments enabled. - UltimateSupreme 12:05, December 23, 2012 (UTC)
I hate the fact that while I answer other peoples questions, no one answers mine. It isn't much of an answers wikia if any questions are left unanswered, if left unanswered, then at least remove or delete them, seems wasteful to just leave them unanswered like that. Kieronrob (talk) 21:20, January 1, 2014 (UTC)
Vandalbot Edit
It's a code programmed to repeat the same vandalism over and over again.Vecanoi (talk) 01:05, October 7, 2014 (UTC)


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Billy CripeShared publicly -
Wondering how Oracle feels about their Gartner placing in the CRM Customer Service Contact Center Magic Quadrant. Siebel gets ranked high, E-Business Suite gets ranked low and Oracle also-rans like fusion CRM and PSFT are mentioned as items that distract and confuse...Guess that is the bitter-sweet of massive acquisitions
Magic Quadrant for CRM Customer Service Contact Centers. 15 April 2011. Michael Maoz. Gartner Research Note G00212151. This Magic Quadrant looks at CRM software for customer service representatives in...


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Have you visited Dr. Nicole Esposito? Rate you experience below.
26 in San Marcos, CA
Dr. Nicole Esposito specializes in psychiatry, family practice in San Marcos, California.
Dr. Nicole Esposito has been compared 105 times. Details of Dr. Esposito's 13 years experience as an MD, her hospital affiliation and education at University of Toledo are available on your free doctor report.
Dr. Nicole Esposito has an average rating of 1 stars (out of 5) with a rating of Poor based on 1 reviews.
Have you visited Dr. Nicole Esposito? Rate you experience below.
Dr. Nicole Esposito has been identified as specializing in Psychiatry and Family Practice.
Insurance plans and networks accepted by a doctor are not necessarily universal across all locations at which the doctor practices. This can be affected by many factors such as different group practices, hospital affiliations and working arrangements at those locations. Checking that the doctor you are visiting and the facility they are at are in-network providers for your insurance plan can save you money and headaches later from surprise medical bills.
Dr. Nicole Esposito accepts the following plans at 150 Valpreda Rd, San Marcos, CA
A hospital affiliation covers any doctor who has an affiliation, association or admitting privilege with a hospital. A doctor's particular affiliation to a specific hospital can translate to the overall quality of that provider.
Dr. Esposito is affiliated with 1 hospital:
Dr. Esposito attended medical school at University of Toledo Medical College of Ohio at Toledo and graduated in 2003 having 13 years experience.
While there is no proven correlation between the quality of one's educational institution and the quality of one's professional competence, it is often an indicator. Medical schools have various levels of selectivity (some are harder to get into than others), and both the quality of their clinical training and level of research are measured. Additional medical training in both residency and fellowships and the facilities they are conducted at also provide a history of the doctors' level of training and experience.
Patients may also know Dr. Nicole Esposito MD as:
277 Rancheros Dr, Suite 301 San Marcos, CA 92069
277 Rancheros Dr, Suite 301 San Marcos, CA 92069
Are you Dr. Nicole Esposito?
Update your information


text:
Police are on heightened alert amid plans by a disparate group of protesters, from left-wing activists to self-styled anarchists, to descend on the capital for anti-Thatcher demonstrations.
Hundreds of activists have been openly discussing protest plans online, with the groups focusing on tomorrow's mass party in Central London rather than Wednesday's funeral.
A single group on Facebook, which calls for a demonstration of "disapproval" in Trafalgar Square and is titled "The Witch is Dead Party", had attracted more than 6,000 members yesterday. Other sites say that the event will be the "party of a lifetime".
Elsewhere, police are prepared for


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"The army is the only way out for a young black teenager. We'll provide you with housing. We'll provide you with education. We'll provide you with everything you need to survive in life. We'll help you to be the best soldier in the U.S. of A." "Because we do more before 7 A.M than most niggers do in their whole lifetime."
[Cube] Huh-huh, huh-HAH..
"I'm comin!" (repeat 3X)
[Cube] I'm comin!
The literal meaning of the song is that Cube wants to murder Uncle Sam:
Uncle Sam being a personification of the United States government, the metaphor is that Cube wants to destroy the government and replace it with something less racist and genocidal.
Note: this song explains what's being depicted on the album's cover art!


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These auctions have special features identified by their unique icons, like Price Freeze, etc.(25)
Take a look at what's coming up for auction and set your Reminders.(738)
Consult the closed auctions to see the amazing deals recently won by fellow Beezidders.(936)
Exclusive auctions with limited seats and some of the biggest and best products!(0)
Keep track of your favorite types of products all in one place.DASHBOARD
Bidding on Beezid is easy, and there are a number of ways you can place a bid. Here are a couple of things you need to know before placing your first bid.
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You can book an Autobeezid (your automated bidding tool) on the auction details page. Some auctions have Autobeezid disabled, such as Bid for Free and Thriller auctions. (You'll learn about those later, in auction types)
Tip: Your bid balance is always visible to you in the status bar. If you want a detailed history of the bids you purchased and how you used them, go into My Account ? My Bid Account in the My Account section.
Yes! You can not only see who is bidding on the auction, but also the last 10 bids placed on the auction as well. This is available for every auction* by viewing the bid history on the product details page.
You will see the usernames of other bidders, the types of bids they placed, and whether they placed a manual bid by pressing on the Bid button or by booking an Autobeezid.
Tip: Viewing the bid history is another tool you can use to develop and refine your bidding strategy. Knowing when to bid, and recognizing who else is bidding on the auction(s) can be very helpful in securing more auction wins.
In My Bid Account, and in the status bar, you'll notice that your bid balance is divided into five categories: Super, Regular, Bonus, Promo and Win bids.
Super bids are a special bid type that you can use whenever you want.
Your health meter: more Health
means more Super Powers!
Promo bids work exactly like Regular bids except for two major differences: they have an expiry date and they are deployed before Regular bids. You can check to see how many Promo bids you have left by checking the status bar or by going to My Bid Account, under Promo bids. To see when they expire, go to the My Account ? My Bonus Offers. To find out how you can get the latest promotional offer, contact our Support Team.
Win bids are the only bid type that can be used on Guaranteed Win auctions. You can only get these if you didn't win an auction with your first Bid Pack purchase. Should that happen, your bid account will automatically be replenished with the same amount of Win bids as the Regular bids from your first Bid Pack purchase.
For example: The first Bid Pack you purchased was for 100 Regular bids. If you used all 100 of those Regular bids from your first Bid Pack without winning an auction, all 100 bids will be returned to you as Win bids. They can then only be used in Guaranteed Win auctions.
If you spend the 100 Win bids in a Guaranteed Win auction without winning, they will be replenished over and over again until you do. This is part of our No-Sting Guarantee.
Remember, you can see the current balance of all your bids on the status bar or in My Bid Account, when you are logged in. When bidding on Beezid.com, all members are subject to Beezid's Terms & Conditions.
You need to sign up and be logged in to purchase bids. Once logged in, click on Buy Bids in the Beezar, or in the My Account section. You will then be able to choose from a variety of Bid Packs.
Tip: When buying bids, you are purchasing Regular bids. Beezid will notify you of all promotions, but feel free to also check in regularly with our Support Team to stay on top of special offers.
Different types of auctions move at different speeds, and if you placed a bid and are no longer the highest bidder, it is most likely because someone else has placed a bid a fraction of a second after yours and, therefore, has become the new highest bidder.
You can verify this by looking at the Bid History on the right side of the details page. There you will find the last 10 bids placed in that auction, as well as who placed them and the type of bid they used.
Should this not be the case, and you feel you may be experiencing some technical difficulties, please contact our Support Team, and they will be happy to help.
Bids cannot be placed on a Future or Stand By auction as it has not begun. However, you can click on the Remind button to be notified when an auction is about to become live. You can set as many reminders as you like, and view all of your reminders by going to My Account ? My Reminders.
You will be notified 24 hours before the auction begins, then one hour prior, and finally five minutes before the auction starts so that you have plenty of time to get in on the action. You can also edit the frequency of your reminders.
Autobeezid and Sniper are very useful tools if you are away from your browser and want to maintain your status as the highest bidder of an auction.
Using the Autobeezid allows you to focus your attention on several different auctions simultaneously. The Autobeezid is an easy and very effective way to win auctions.
Note: The Autobeezid has three distinct ways of working for you, depending on the type of auction. Consult the chart below to see how the Autobeezid behaves for each auction type.
For twice the action at twice the speed! Designed to immediately outbid your opponent, these will ensure that you are the highest bidder at all times.
If you're looking for a little more speed than look no further. These auctions are designed to move quickly!
Keep your opponents guessing! By placing bids for you in the last few seconds of the auction, other bidders will scratch their heads wondering what's coming next.
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Autobeezids are deployed earlier in the countdown timer, giving them a bit of a speed boost. Like auctions with caffeine!
Bids are placed at different intervals in the last few seconds of the auction to help you secure that big win. Keep others guessing what's next!
Strengthen your safety net with double the usual amount. That's 20 Snipers!
More Snipers means smarter bidding. The limit is set to 10!
This one comes equipped with 10 Snipers. Make sure to use them wisely!
You can book the Autobeezid as many times as you want in an auction. Limits apply only to the total amount of bids you can place in a single Autobeezid booking.
As powerful as Autobeezids are, they risk remaining dormant if the auction price never reaches the starting price range that you specified. We've got you covered though with our exclusive safety net feature: the Beezid Sniper.
The Beezid Sniper increases your ability to become the highest bidder and prevents an auction from ending. If used properly, a Sniper can ensure you do not miss out on great products. Snipers place their bids within the last three seconds of an auction's countdown timer and look just like Regular bids.
You can book a Sniper from anywhere you see an auction, unless it's a Thriller auction (see auction types). Simply set it up and let it do the rest.
Tip: Your Sniper can only be booked once per auction, so make it count!
Given the automated nature of Autobeezids and Snipers, these features can place bids faster and more accurately than any human can. They can, in fact, help delay the outcome of an auction, all without taking away from the excitement.
The Autobeezid will place your bids at different intervals in the last few seconds of the auction, increasing the strategy by letting your opponent wonder how many bids you have booked.
Autobeezids are deployed earlier in the countdown timer than Turbo. The timer resets and counts down until the next Autobeezid deploys.
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Snipers allow you to place bids during the most intense moments of the auction: in the last three seconds of a timer's reset countdown. The advantage to this is that you can get sneaky last second bids in, while never having to worry about Internet lag. Make sure you have Snipers available! Beezid Snipers never miss.
At Beezid, we've come up with a long list of tips, meant to help you get familiarized with our site, bidding and developping strategy. Some of these may help you tremendously when bidding but keep in mind, they do not provide any guarantees of winning an auction.
If you have some helpful tips that you'd like to see added to this list, feel free to contact our Support Team and let them know.
© Copyright 2016 Beezid Inc.
Beezid®, Beezid.com, the Beezid® Bumblebee and all other Beezid® related marks, images and symbols are the exclusive properties, trademarks and tradenames owned by Beezid Inc. Designated trademarks, logos and brands are the property of their respective owners.


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With 1/4"-20 and 3/8" screws. Replacement for Daiwa-05 fluid head.


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female voters
Donald Trump's latest rude comments about Ted Cruz's wife are raising new alarms among Republicans about the party front-runner's ability to win over women, especially in a potential fall presidential match-up with Hillary Clinton. Continue reading
Coming off the vice presidential debate, Jeffrey Brown talks to Democratic pollster Celinda Lake and Republican pollster Kellyanne Conway about the ways the presidential candidates and their running mates have or haven't addressed issues that are important to female voters, paying particular attention to the debate performances. Continue reading
Sen. Kirsten Gillibrand, D-N.Y., and California attorney general Kamala Harris talk to Judy Woodruff and Gwen Ifill about the role of women in politics, how equal pay for men and women helps support the economy, and how everyone should have the right to make decisions for one's own body, including reproductive rights. Continue reading
Although female voters had been leaning Democratic so far in this presidential campaign, Gov. Sarah Palin has brought new appeal to the Republican ticket for socially conservative women. Two analysts examine issues that concern women and how these will influence their vote, especially for Hillary Clinton's former supporters. Continue reading


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Neil and Asin are just friends!
Written by: By Gayathry V Pillai
Now the latest buzz on the actress is that Asin and Neil Nitin Mukesh. Recently two of them were spotted getting cozy with each other at a sub-urban five-star restaurant in Santa-Cruz! The two looked very comfortable with each other. They came together, they left together. It seems thtat neil is quite comfortable with what is going on with him....dating!.
The actor was earlier spotted with Deepika Padukone watching her movie Karthik calling Karthik. He is not bothered about his 'lost love' now. He commented that Asin and himself are very good friends and he is not dating her. But they are very good friends. And now all knows failure is the stepping stone to success..and may be for some friendship is the ladder for love..
Read more about: gayathry v pillai, asin thottumkal, deepika padukone, neil nitin mukesh
Other articles published on Mar 26, 2010


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Hilton Cocoa Beach Oceanfront - Cocoa Beach
A restaurant, dry cleaning/laundry and ATM/banking are offered at this hotel. Go for a dip in the outdoor pool during your stay. There is also a poolside bar and a bar/lounge so guests can sip a refreshing drink by the pool or indoors. The leisure facilities include a fitness center.
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Hilton Cocoa Beach Oceanfront - Cocoa Beach
Hotel Info: 855-239-9397from $139
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- Check-in time 4 PM-11:30 PM
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Required at check in
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Travelling with others
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- WiFi in public areas *
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In the hotel
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Breakfast is offered for an extra charge of USD 17.00 per person (approximately)
WiFi is available in guestrooms for USD 3.95 per day (rates may vary)
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High-speed Internet access (wired) is available in guestrooms for USD 3.95 per day (rates may vary)
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text:
ParagonX9 - Chaoz Airflow
Credits & Info
- Uploaded
- Jun 11, 2009 | 6:12 PM EDT
- File Info
- Song
- 4 min 14 sec
- Score
- 4.33 / 5.00
Related Content
Heard in 30 Entries!
View all submissions featuring this audio file.
Licensing Terms
You may not use this work for commercial purposes without making specific arrangements with the artist.
- Score:
- Rated 4.33 / 5 stars
- Plays & Downloads:
- 535,867 Plays | 468,915 Downloads
- Share Links:
- Genres:
- Electronic - Drum N Bass
- None
Author Comments
Rated 5 / 5 stars
While I think the drums are overpowering, the melodic sections of this song were absolutely superb. The ending part of the melody actually reminds me of Golden Sun's battle theme. I will never understand how you can possibly master songs this well xD
It was a similar style to Chaoz Fantasy, but that song is still my definition of the greatest song every composed. Sorry :P
Rated 5 / 5 stars
Rated 5 / 5 stars
Just like everything you do. A little Sonic esq. feel to it. Love the sound love the break, love the start... the only thing that sucks is that it doesn't last for ever...
Rated 5 / 5 stars
I like this song... it sounds me like freedom and action in one person on beach who face the sun on horizont and he is preparing to run fast to sun from little island full of enemy.And in midlle of song just jump and stop in sky to recharge energy from wind and prepare to run again!..:D Great and good work. :D
PS: Where is the secret??? in your music that is great :D.... I wish if i could be that good as you :-)
Rated 4.5 / 5 stars
Another nice song
I start to listen Drum N Bass due to Chaoz Fantasy. It's really a nice song from Fantasy and Impact in Chaoz series. Partly somewhat like Metropolis [8-Bit]
Below is my little subjective opinion
-This song make me recall a flash game about aircraft (an excellent flash game). Song title is matching the song.
-Main melody is clearly.
-A complete ending.
-An essential element for a good song is the song has undulation. Here is a good upper wave and lower wave (love this part very much. Ambient + Drum N Bass). Great job.
-However, I think this song's base style is a bit like video game. (base style is very not important)
Overall, nice song and well done. I love it
Score: 5/5, 9.44/10


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Posts Tagged 'Joseph Conrad'
A Polar Wind: Robert Kloss and Matt Kish in Conversation
September 29, 2015 | by Robert Kloss and Matt Kish
On the relatively short list of authors and artists who have collaborated on multiple books, there are few who so perfectly mirror one another's sensibilities that it becomes difficult to imagine art and word as separate entities. I'd place Aleksei Kruchenykh and Olga Rozanova, A. A. Milne and E. H. Shepard, Roald Dahl and Quentin Blake in that select group. And now I'd add author Robert Kloss and artist Matt Kish. The pair have, to date, worked together on two novels (Alligators of Abraham and The Revelator), a hybrid novel written with Amber Sparks (The Desert Places), and an ongoing project they call the "Bestiary."
The two have published work independently—Kish, notably, has illustrated every page of Moby-Dick and Heart of Darkness—but their joint efforts are of a different order, primarily because, being of like minds, one's work influences the other's in the course of making. The Revelator, which was just published this month, is a psychologically brutal tale about an itinerant zealot in nineteenth-century America. In the opening paragraphs, a group of forlorn sailors, "their faces blistered and their minds bleached and weary," espies a mountain: "some named it the 'Finger of the Evil One,' and some called it a tower of soot, dreamed it an ancient citadel misshapen by flame, the horror of all trapped within." Kish's illustrations, sprinkled throughout, are correspondingly prophetic, alien, and apocalyptic.
Kloss recently moved from Boston to Boulder, Colorado; Kish lives in Ohio. The two have never met. Earlier this month, they conducted a conversation via online chat about the nature of collaboration and working in the shadow of Melville.
—Nicole Rudick
Kish: I've been thinking about this conversation for some time, alternately veering between excitement and intimidation. Aside from our numerous e-mails, this will probably be the most in-depth communication we've shared, at least on a sustained level.
Kloss: Let's start with Melville then, since I don't think we would be having this conversation without his work. Read More »
This Week on the Daily
December 7, 2014 | by Dan Piepenbring
Our new Winter issue is here. Learn more about its cover, which features a photograph from Marc Yankus.
"Art isn't always what—or where—you expect to find it." Nicole Rudick looks at art ephemera.
Walter Benjamin used to write a radio show for children—here he tells a story with thirty brainteasers. (We'll post the answers on Thursday.)
"I think poetry is always one or two poets away from extinction." Michael Hofmann and Jack Livings talk about poetry, translation, and Vespas.
An interview with Julia Wertz about her online comic, Fart Party, now collected in a new book, The Museum of Mistakes. "I'm a real bitch in my work. No one likes a happy-go-lucky character—that's the character everyone wants to see destroyed."
Twenty-five years after Wild at Heart, Barry Gifford's novels are still weird on top.
Two centuries after the Marquis de Sade, a French exhibition traces his influence.
Plus, Sadie Stein sees how far a full-page ad in The New York Times goes; and Joseph Conrad thinks the world is plenty mysterious enough as it is, thanks.
Marvels and Mysteries
December 3, 2014 | by Dan Piepenbring
How would you define fantastic, then?
I wonder if you can define it. I think it's rather an intention in a writer. I remember a very deep remark of Joseph Conrad—he is one of my favorite authors—I think it is in the foreword to something like The Dark Line, but it's not that …
The Shadow Line?
The Shadow Line. In that foreword he said that some people have thought that the story was a fantastic story because of the captain's ghost stopping the ship. He wrote—and that struck me because I write fantastic stories myself—that to deliberately write a fantastic story was not to feel that the whole universe is fantastic and mysterious; nor that it meant a lack of sensibility for a person to sit down and write something deliberately fantastic. Conrad thought that when one wrote, even in a realistic way, about the world, one was writing a fantastic story because the world itself is fantastic and unfathomable and mysterious.
You share this belief?
Yes. I found that he was right. I talked to Bioy Casares, who also writes fantastic stories—very, very fine stories—and he said, "I think Conrad is right. Really, nobody knows whether the world is realistic or fantastic, that is to say, whether the world is a natural process or whether it is a kind of dream, a dream that we may or may not share with others."
—Jorge Luis Borges, The Art of Fiction No. 39, 1967
Since it's Joseph Conrad's birthday, I went in search of his foreword to The Shadow Line—it was an author's note, actually, appended to the novel's second edition in 1920. And Borges's memories of it are largely accurate: Conrad uses it to mount a defense of "the world of the living," which "contains enough marvels and mysteries as it is … I am too firm in my consciousness of the marvellous to be ever fascinated by the mere supernatural."
The Shadow Line, which is now in the public domain, was first published in 1916, when it appeared over the course of two months in Metropolitan Magazine. It tells the story of a young man who assumes the captaincy of a ship in "the Orient." The ghost of the ship's previous captain, Mr. Burns, lurks: "His face in the full light of day appeared very pale, meagre, even haggard. Somehow I had a delicacy as to looking too often at him; his eyes, on the contrary, remained fairly glued on my face. They were greenish and had an expectant expression."
Here's the author's note Borges mentions: Read More »
A Downright Incantation
December 3, 2013 | by Sadie Stein
Everyone knows that Heart of Darkness was adapted as Apocalypse Now, but have you ever listened to the 1938 radio version Orson Welles did with the Mercury Theatre? The sound quality is poor, but it's compelling nonetheless.
The Man in Black, and Other News
February 8, 2013 | by Sadie Stein
Conrad Signals, Server Signs
August 10, 2012 | by Sadie Stein


text:
Roslyn Kind Sang At Brooklyn College, and I Was There
Barbra's half sister Roslyn Kind has a strong, lovely voice, which she applied to a series of standards at Brooklyn College the other night--everything from "All That Jazz" to "Losing My Mind" to "Meadowlark" and beyond.
And she's funny, too.
Roslyn remarked, "Apple created the best phone ever, and they hire AT&T to service it. It's like hiring a hooker to babysit your child!"
Spotting a fan in the audience, she said: "She flew in from Florida today for this concert. It's really great having rich stalkers. So much better than the ones that jump out of the bushes!"
Upcoming Events
And after insisting that the tech person fix the sound--which indeed needed fixing--Roz smiled and said: "I hate to be a kvetch. It's a side of myself that don't like to have. But I'm Jewish--it comes with the territory!"
By the way, Roz never directly mentioned her sister, probably so as not to seem exploitive. It's a very classy approach, though Barbra becomes a bit of the elephant in the room.
Still, Roz did give us some childhood insight at the gala afterward.
She said her mother happened to be a wonderful singer--Ma's father was a cantor--but she didn't pursue it. Instead, said Roz, she passed on her wonderful genes to the kids.
So true--and the genes were enough to create two great singers.
So nu?
Get the This Week's Top Stories Newsletter
Every week we collect the latest news, music and arts stories — along with film and food reviews and the best things to do this week — so that you'll never miss Village Voice's biggest stories.
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beer for my horses
anybody see this? its on cmt this sunday but it was supposedly in theatres? never was up here. the movie stars rodney carrington and toby keith and a handful of other country stars. looks good
2011 Cruze
R.I.P. Will Iott
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Yeah I've been wanting to see it, I think Ted Nugent, Toby Keith and some others play in it, supposed to be pretty good, its too bad they didn't play it in theatres up here...damn liberal theatres...haha
Early 99 F250 4x4 CCSB w/ LATE 99 engine - TW Chip, 5" straight exhaust, DIY intake w/ Amsoil 4095 filter, Gauges, ITP Pre pump filter and tank mod, Riffraff IC boots, AIH delete, EBPV delete, Foil delete, 3" lift on 35" BFG KM2, , custom rear bumper, Lightforce 170 lights
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NTE518 - R-si 10kv 25ma
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April 29 2013
Pierre publisher elected president of South Dakota Newspaper Association
Steve Baker, publisher of the Capital Journal in Pierre, was elected president of South Dakota Newspaper Association on April 26 during the annual newspaper convention in Rapid City.
Baker has been a publisher for Ogden Newspapers in Minot, N.D., Lee Enterprises in Burley, Idaho, and Media News in Red Bluff, Calif.
Baker returned to the Dakotas in 2008 when he was named the publisher of the Capital Journal in Pierre. The Capital Journal is owned by Wick Communication, a family-owned media company with holdings in several
Baker and his wife, Kim, have one child, Kelly. Kelly, his wife, Danielle, and their son, Lucca, live in Fargo, N.D.
Baker said one the focuses of his term as president will be to continue the work on open government issues including the publishing of public notices.
"This is not just a media issue; our readers need to be aware of the consequences of government policing itself," Baker said. "Freeman Courier Publisher Tim Waltner said it best when he said there are three key aspects of public notices: permanence, verifiability and independence."
Baker has also been an advocate for the newspaper industry in the South Dakota Legislature.
During this year's legislative session, Baker testified on Senate Bill 119, which prohibits public schools from entering into exclusive contracts for news media coverage of interscholastic events such as football and basketball games. The bill was approved by legislators and signed into law by Gov. Dennis Daugaard.
Baker said after living and working in other states, he is thrilled to be in South Dakota.
"This is home for us," he said.
Also elected to the SDNA Board of Directors were: First Vice President Paul Buum, publisher of The Alcester Union & Hudsonite; Second Vice President John Suhr, publisher of the Reporter & Farmer, Webster; Third Vice President Jan Kittelson, of the Miller Press, Wessington Times Enterprise and Wolsey News; Director Randell Beck, publisher of the Argus Leader, Sioux Falls; Director Becky Tycz, publisher of the Scotland Journal, Tyndall Tribune & Register and Springfield Times; and Immediate Past President Charley Najacht, publisher of the Custer County
Chronicle, Hill City Prevailer and Winner Advocate.
The SDNA Board members were elected at the association's annual business meeting held in conjunction with the convention.
South Dakota Newspaper Association, founded in 1882 and based in Brookings, represents 130 weekly and daily newspapers with a total readership of more than 600,000.
- Lyman County Pheasants Forever Chapter holds banquet
- Hunters average two birds in Lyman Co. during opener
- National Fire Prevention Week, October 9-15
- Hoops for Coop
- Lyman Celebrates Homecoming
- Fall Harvest Underway
- LHS to crown King & Queen Monday, Sept. 26
- Lyman PF Chapter plans Banquet
- Kennebec hosts Rodeo for Cowboys and Cowgirls, age 4 to 18
- GLF Update: "The Miller Challenge"
- Pheasant survey indicates Lyman County routes among highest in state
- Court rules on County State's election


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- Soil Association
- What We Do
- Organic Standards
- Soil Association Organic Standards
Soil Association Organic Standards
No system of farming has higher levels of animal welfare than organic farms working to our standards. Our organic standards use the EU organic regulation as their baseline, but in many cases our standards are more robust.
From time to time, we hold public consultations on our standards. We encourage you to get involved and participate in these consultations.
The current version of the standards are organised by sector below:
Useful Links
An amendment to the EU organic regulation has been published*. It covers permitted substances and practices for use in organic farming, growing, food manufacture and aquaculture. Find out more about these changes here.
- EC Regulation No 834/2007 on organic production and labelling of organic products
- EU Regulation No 889/2008 laying down detailed rules for the implementation of Council Regulation (EC) No 834/2007 on organic production and labelling of organic products with regard to organic production, labelling and control
- European Commission Organic Farming
- International Federation of Organic Agriculture Movements - EU Group (IFOAM)
- IFOAM norms (for International Grower Groups, see section 8.3, as referenced in Soil Association standard 2.3.4)
- National Organic Program (NOP) - USDA Regulation
- Canadian Organic Regime (COR) - General principles and management standards and Permitted substances list
- Aquaculture: EU Production rules for aquaculture licensees are detailed in EU Regulation No 889/2008, with further amendments published via EU Regulation No 1358/2014
- EU importing guidelines (for International Grower Groups, see section 8)
*New EU regulation 2016/673 amends EC 889/2008.
In this section...
Standards Board
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Standards Consultations
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