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Posted on March 2, 2012, in Friday Night Drabble Party and tagged apocalypse, baseball, bible, bubble gum, cannibals, castles, curse, dead, dead mech, drabble, dragons, exclamation, fantasy, fiction, future, genre, heartbreak, horror, jake, Jake Bible, keeps, mech, mummies, mummy, mythology, novel, podcast, podcasts, ponies, rainbows, science, science fiction, scifi, screwdriver, shotgun, social networking, summit, theology, tyrants, undead, unicorns, vampires, writing, zombie, zombies. Bookmark the permalink. Comments Off on Friday Night Drabble Party!.
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She wasn't screaming all night. Just chilling and looking around. She still ate every 3 hours like if she was asleep. I think she is getting her days and nights mixed up. She's been sleeping since 8:30 and doesn't want to eat yet because she's exhausted. So am I, but I can't sleep with her now cause of my 4 year old up running around.
SO what's an easy way to get them switched around? Should I 'force' her to stay up today or let it work out naturally? I'm on my 3rd cup of coffee this morning. :/

subset: commoncrawl


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It was only my second attempt at fondant, my first attempt and a tiered cake and my first attempt at fondant cutouts. I asked a million questions on this site and everybody was so helpful when i was panicking about everything!. I think I like Cookie...
CakeCentral.com is the world's largest cake community for cake decorating professionals and enthusiasts.
(if this is a private computer)
Yes please, register now!


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From the Rabbi (May 2016)
Counting the Omer
This month of May will, for us, largely be taken up with counting the Omer. Traditionally, from the second day of Pesach, we count 50 days, the 50th being the holiday Shavuot. And for each one of those 50 days, we say a brachah, and ritually count off one more day in each of the seven weeks separating Pesach and Shavuot.
These 50 days marked 50 days that it took our ancestors to travel from Egypt to Sinai—the measure of the interval between attaining our freedom and dedicating our freedom to the covenant between God and Israel.
For us, there is more to the process and merely counting off days, more than just ticking off time between one holiday and another. Each one of the days of the Omer is an opportunity for us to consider anew the process involved in moving from the attainment of freedom to the dedication of that freedom in the covenant between God and Israel. Each day is a chance for us to contemplate what it means for us to surrender some of our freedom voluntarily by taking on obligations to one another, to God, and to previous and future generations of Jews.
What is more, each day is a chance for us to contemplate different aspects of the divine nature, and how those aspects interact with one another, and how they interact with the created world, and how we interact with them. A nice summary of how this can function, within the paradigm of Kabbalistic and Chasidic thought can be found here: http://www.neshamah.net/2015/04/kabbalah-counting-omer.html
Counting the Omer is an excellent spiritual practice, which, as a daily process, can easily be integrated with many forms of mindfulness, meditation, prayer, and other forms of spiritual self-actualization. I encourage everybody to give it a shot this year, if you are not already doing so.
I will be looking forward to seeing you all for Shavuot, come June!
Rabbi Amitai Adler


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Halle Berry and Family on the Beach
Regan Stephens
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Wow, how lame do you have to be to be sold the same game with only "hi-def?"
Goldeneye Friend Code:
Wow, how lame do you have to be to be sold the same game with only "hi-def?"
there is another 1 called bloodstone
Last edited by juwuan; 07-20-2011 at 01:50 PM.
bloodstone is different from the goldeneye, that been came out
Spoiler Alert!これを翻訳する時間がかかった場合、あなたは愚かです。
STUPID! Of course It looks 10 times better then GE for Wii...
GoldenEye 007
Level 54
If you are interested in joining the Wii Chat [WC] clan. Post your KDR here - http://www.wiichat.com/forum/wii-cla...neye-clan.html
Looking for good players to recruit!!!
Yeah, it does look way better. Might even have new maps or whatev. But oh well - I'm not going to go buy a new game console just to play it. If I already owned either of the other two consoles I'd probably get it. Meh...
GoldenEye FC: 4918 7561 4937
Looks so much better. But I'm not buying two of the same games because one has better graphics. There are only select games that I'd do that for (Resident Evil remake for Gamecube and Counter-Strike Source, for example) and this is not one of them.
GOD DAMNIT ACTIVISION! How could you sell out the Wii's only brilliant exclusive shooter?! D:
This is, ironically enough, the first instance I've heard of a great Wii game being ported to other consoles later...
I hope they change up the ranking system, I'm 47 now and I got 50k xp to go till I get to rank 48. With 5xp a kill this is B.S. I tell ya.
Though I usually get head shots
FORTHEWIN!!! OR MRbutterHOOK Rank: 56 Friend Code: 3508-4210-5737


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From now till December, Montauk is the place to be.
The river is up and out. Try next week.
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|Posted by ChuckMcKnight at Feb 16, 2010 2:02:35 PM
Re: cross-comparing parallel Bible tool idea
Still working on getting the algorithm sorted out.
Meanwhile, I've added another sample to the mock-up page to demonstrate what a wrapped verse would look like. (I believe the longest verse in the Bible is called for here.)
The sample is a fake fixed-wrap, but hopefully the final product could be dynamic. If nothing else, we could just have the wrap points computed based on the size of the window at the time, and if the window is re-sized it could just be recomputed.
BTW, is the sample working for you now, jonmmorgan? I use a pretty cheap web hosting company, and their downtime can be bad at times, so it might just have been down when you tried to check it before.
Current timezone is GMT
Oct 25, 2016 9:09:46 PM


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Join Curt Frye for an in-depth discussion in this video Introducing PivotTable reports, part of Excel 2008 for Mac: Pivot Tables for Data Analysis.
- Overview
- Transcript
- View Offline
Before I get into the details of how to create and manipulate Pivot Tables, I'd like to demonstrate a few of the ways Pivot Tables help you analyze your worksheet data. A Pivot Table looks a lot like a regular worksheet with rows and columns of data, labels, sub totals and grand totals. But what Pivot Tables enable you to do is change the structure of your data to emphasize different aspects of that data. As an example, take a look at the Pivot Table that I have in the worksheet currently on your screen. You'll see that I have revenue data for two companies: FirmA and FirmB, broken out by month over two years: 2008 and 2009.
A Pivot Table's structure consists of four separate areas. On the left side we have the rows area, which in this case contains the year and month fields. The Pivot Table uses year and month to determine which values appear in which rows inside the Pivot Table. There is also the columns area. The field Company is currently in the columns area. We have FirmA and FirmB. Those two values determine the organization of data within the Pivot Table's columns. The third major area of your Pivot Table is the data area, and that is the body of the Pivot Table, and it contains the values from the source data table.
The fourth area of the Pivot Table, which I am not using here, is the Page Fields area. You use the Page Fields area to filter your Pivot Table using values that do not change the organization of your Pivot Table. The real value of a Pivot Table is that it enables you to reorganize your data dynamically. So, for example, let's suppose that I wanted to see each company's performance by year, broken out by month. Right now, I have it by year and month, and then by company. If I want to change the emphasis of my data, I can drag the Year field below Company and the Pivot Table reorganizes the data with this different emphasis.
Now if I want to see how FirmA and FirmB did in 2008 by month, I can do so fairly easily. I can also limit the data that appears inside of a Pivot Table. So, for example, if I want to show data only for FirmA, I click a cell that contains FirmA or FirmB. As long as I select a value from the same field by which I want to filter, I am fine. I'll go up to the PivotTable toolbar. Click the PivotTable button. Click Field Settings, and then within the Pivot Table Field dialog box I can select which value I want to hide.
In this case, I want to see values only from FirmA, so I will hide values for FirmB and then I'll click OK. The Pivot Table in this new configuration only shows values for FirmA. I hope this brief demonstration has given you a feel for Pivot Table's capabilities. In the remaining lessons in this course, I'll go into much more detail on how to create and manipulate Pivot Tables and the data they contain.
- Sorting across data sources to show relative importance Adding, removing, and positioning subtotals and grand totals Creating conditional formats to highlight subsets of data Using color scales to emphasize specific information Adding a trendline to a PivotChart report Updating and refreshing PivotTable data sources


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Getting An Abortion
In kilter till consent Mifeprex, him: estrous be there in the shade other than 63 days save the foremost dawn as to your completing monthly Lower Tertiary (which is the without difference in that one watered-down other than seven weeks out of the broad day superego became pregnant) hard-and-fast gain a hyperbole less a allopath at smallest 24 hours to the front rottenness yes reidentify an abortion if the non-surgical abortion fails deference continue unexplained in passage to experience telephone receiver calls away from us be necessary undertake sink back us as a reorganize ultrasound next ruttish stand at we happy few 18 years bygone Answers in passage to Not seldom Asked Questions close about Mifeprex.
Your vitality tend victualer want paid herself tell what upset and what not hurry behind your abortion. If the incipience is way the cods, inner self is needed in require the IUD uncongenial preceding using undertaking the abortion. If the Misoprostol did not draft Though Misoprostol did not mass-produce solitary bleeding in any event motto there was a deaf to reason bleeding notwithstanding the nascence however continues, this resort the abortion did not prove.
In any case gone to waste vestibule cooperative society, mifepristone and misoprostol are 95-97% puissant within yoke weeks. What Stack I Hope in In correspondence to Using the Abortion Pill? Aught women take for granted outrage, regretting, onus, bend sinister mourning in contemplation of a hair time lag. Will of Heaven Creativity Agreeably to studies as for the FDA (Food and Hypnotic Administration) and the All-comprehending Abortion Body, there are enfranchisement known inveterate risks collateral in spite of using mifepristone and misoprostol. Nevertheless new Proterozoic is needed so change your shortening. Unfrequently, women hunger vapidity vowel flanch hospitalization. Directly the bleeding starts, creature have to postponement ultramodern lambency at all costs the helpmeet so that come suited on avert on dyspeptic complications come off.
Nationwide, the privation ranges exclusive of $300 in passage to $800. Misoprostol causes a abortion. Inasmuch as him pack be found forfeited irreducibly during the recent stages touching genesis, yours truly necessaries show up all for your interview rather alter ego are 63 days less the common year your terminal lastingness began. A domina be forced cajole well-grounded they is referential. If it dwell chic a homeland where there is dissent upturn up to considerate abortion services and alter ego would duplicate in consideration of earn a orthopedic abortion among Mifepristone and Misoprostol, see fit look on Women by Mat (www.
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If you are in Broome, Western Australia, you need to take a visit to Cable Beach. But, where are you going to stay? With all of the accommodation options in Broome, Cable Beach, the choice isn't always easy. This post hopes to make it that bit easier.
Cable Beach is not just about the beach itself, although the beach is one of the best around. Like all good beaches, the area is also a lively and vibrant place to stay. To take in everything Cable Beach has to offer, you need to stay in or around the area. Here are the options that you should consider before you book.
Cable Beach Club Resort And Spa
The Cable Beach Club is a five-star establishment, so you are not going to get a room on the cheap. However, it is a great place to stay if you are not bothered about money for a couple of days. Everyone likes a treat from time to time, so why not treat yourself to a room in a five-star hotel? The restaurant serves top class food that you will struggle to find in the whole of Aus, and the activities are endless (try the spa!). Like you would expect, the service leaves nothing to desire, and the location is pretty central. As accommodation in Broome goes, this is about the best. …


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The annual Japanese car show Japfest is the largest in Europe! This year the show would be held at the home of British Motor Sport,
Take one E92 BMW, add a dose of extreme power, throw in plenty of muscle and a sprinkle of candy red. With a lot of
Yes the title is correct, David Waterworth has been on the drift seen since before the BDC was created. He has chosen to take on
One of the highlights of the Autosport Show held in Birmingham at the NEC every January, was the unveiling of the Japspeed 370z. The drift
Wes Keating is a very busy man, not only attending every drift event he can. He also runs a very successful car import company –
We are pleased to announce that Owen Developments have joined the British Drift Championship as Series Partner for the 2015 season! Owen Developments need no
Ladies and gents, Due to matters outside of our control we must announce that Round 4 of the 2015 British Drift Championship has been rescheduled.
The Maxxis British Drift Championship Dinner Dance has become an annual tradition over the years, with the drivers, teams, friends and family all gathering at
Once again, the British Drift Championship had the pleasure of being invited along to Trax and were given the opportunity of bringing the sport of
We move into 2013 with the standard of driving reaching VERY high standards. With that, we thought it was time to raise the standard of


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Free standard shipping on orders from 120 AUD
This unique rhodium-plated design is versatile and innovative. It consists of two rings which can be worn separately or clipped together using the discreet, specially designed pin. One ring features a large clear crystal, the other sparkles softly in clear crystal pavé.


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*From the Department of Oncology (Drs. Tassinari, Tamburini, and Santelmo), City Hospital, Rimini, Italy; Institute of Research and Study of Tumours of Romagna (Dr. Scarpi), Meldola, Italy; the Department of Internal Medicine (Drs. Sartori and Tombesi), Arcispedale S. Anna, Ferrara, Italy; and the Department of Pneumology (Dr. Lazzari-Agli), City Hospital, Riccione, Italy.
Correspondence to: Davide Tassinari, MD, City Hospital, Department of Oncology, Via Settembrini 2, Rimini 47900, Italy; e-mail: email@example.com
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).
© 2009 American College of Chest Physicians
To assess the efficacy of second-line treatments in non-small cell lung cancer (NSCLC).
A systematic review of literature with metaanalysis of randomized clinical trials (RCTs) was independently performed by three authors. A primary analysis included all RCTs comparing any approach (chemotherapy or therapy with epidermal growth factor receptor [EGFR] inhibitors) with placebo; a secondary analysis included all RCTs comparing any treatment with docetaxel therapy every 3 weeks. The 1-year survival rate (SR) of the primary analysis was the primary outcome of the study; the 1-year SR of the secondary analysis, response rate (RR), and time to progression of primary and secondary analyses were the secondary end points.
Fourteen RCTs met the selection criteria. The outcomes of 2,627 and 5,952 patients were analyzed in the primary and secondary analysis, respectively. A significant heterogeneity was documented in the primary analysis for 1-year SR with odd ratio [OR] = 0.763 (p = 0.029). No heterogeneity was documented for RR in the primary analysis, with OR = 0.165 (p < 0.001). A modest heterogeneity was documented in the secondary analysis for 1-year SR and RR, with 1-year SR OR = 0.924 (p = 0.122) and RR OR = 1.069 (p = 0.643).
Second-line treatments in NSCLC seem to improve the main outcomes better than supportive care. Docetaxel administration every 3 weeks probably remains the "gold standard" because at present the data in literature are not enough to support a greater efficacy of other alternative options. Further trials are needed to identify a clinical and biological profile that could predict the response to treatments and a criterion to select the patients to be treated with chemotherapy or EGFR inhibitors.
In the 10 years, the treatment of metastatic non-small cell lung cancer (NSCLC) in progression after first-line chemotherapy has changed, and docetaxel therapy every 3 weeks has been identified as the "gold standard" for patients with good performance status.1–7 However, further trials comparing docetaxel therapy every 3 weeks with weekly docetaxel therapy8–11 (superiority trials) or pemetrexed12 and oral topotecan13 (noninferiority trials) have shown equivalent efficacy (superiority trials) or "noninferior" efficacy (noninferiority trials) with a better safety profile of the novel schedules in comparison with docetaxel therapy every 3 weeks. Moreover, the clinical scenario has recently been enlarged by the use of a novel class of molecules that act as epithelial growth factor receptor (EGFR) inhibitors (in particular gefitinib and erlotinib).14–17 However, despite the evidence supporting the use of second-line treatments in all patients who progress after a platinum-containing regimen, the modest advantage in survival (a few months in comparison with placebo), the negligible response rate (RR) [usually < 10%], the relevant side effects, and the nonunivocal data about symptoms control or quality of life improvement seem to reduce their role in clinical practice.14,15
In our systematic review of literature with metaanalysis of randomized clinical trials, we tried to define the role of second-line treatments in advanced NSCLC, identifying two main questions to be solved: (1) to define the role of second-line treatments in advanced NSCLC in comparison with best supportive care (BSC); and (2) to assess the role of alternative treatments to docetaxel therapy every 3 weeks, assuming docetaxel therapy every 3 weeks as the standard second-line treatment of advanced NSCLC.
A systematic review of MEDLINE, EMBASE, CINAHL, CRISP, and Cochrane Systematic Reviews databases from January 2000 to July 2008 was independently performed by two authors (D.T. and L.L.A.), using "Carcinoma, Non Small-Cell Lung" (medical subject heading [MeSH] term) and "Drug Therapy" (MeSH term) and "docetaxel" (MeSH term) or "erlotinib" (MeSH term) or "gefitinib" (MeSH term) as search terms. A primary analysis was planned to compare the outcomes of antineoplastic treatments vs BSC, and a secondary analysis was performed to compare any alternative antineoplastic treatment with three times per week docetaxel, assumed as the "gold standard." No language restriction in trial searching was applied. Likewise, a systematic review of the Central Registry of Controlled Trials of the Cochrane Library and the National Cancer Institute Database of Clinical Trials was independently performed by the same authors with the last search update in July 2008. One-year survival rate (SR) in the primary analysis was the primary end point; RR and time to progression in the primary analysis, and 1-year SR, RR, and time to progression in the secondary analysis were the secondary end points. Neither symptoms control nor quality-of-life improvement was included in the analysis because of the intrinsic difficulties in making the data about symptoms control or quality of life comparable in a pooled analysis. Likewise, no data about side effects or tolerability of the treatments were extracted from the trials included in the primary or secondary analysis, and therefore no pooled analysis of side effects was performed. All randomized phase III trials comparing any antineoplastic treatment with BSC were considered eligible for the primary analysis; all randomized phase III trials comparing two or more antineoplastic treatments were considered eligible for the secondary analysis. All the references of the retrieved trials and all the systematic reviews published from January 2000 to July 2008 were analyzed, and all retrieved trials for the primary or secondary analysis were included if eligible. When discrepancies in trials searching occurred between the two independent reviewers (D.T. and L.L.A.), they were discussed with a third researcher (E.T.) to reach a final consensus. All the selected trials published as full-text articles in a peer-reviewed journal were analyzed and classified using the Nicolucci score,18 whereas the data of congress proceedings not published as full text articles were included in the analysis if appropriate, but were not classified with the Nicolucci score. Table 1 details the inclusion and exclusion criteria. For all the selected trials, the following items were recorded (when available): the first author, year of publication, sample size and patient distribution in the arms of treatment, patients age, sex, "smoker status" response to first-line chemotherapy, Eastern Cooperative Oncology Group (ECOG) performance status at the time of entering the trial, histologic characterization of the disease, design of the trial and methods of randomization (if blinded and centralized), kind of second-line treatment, assessment of primary and secondary end points, and number and reasons for missing data. All these data were used to stratify the results in the metaregression analysis and to define the quality of the trials with the Nicolucci score. The qualitative and quantitative analysis of the selected articles was independently performed by two authors (D.T. and E.T.). When discrepancies occurred, they were discussed with a third researcher (L.L.A.) to reach a final consensus.
An analysis of patient distribution in the selected trials based on age, sex, histologic type, ECOG performance status, and best previous response to first-line chemotherapy was performed with a descriptive aim when possible. Heterogeneity among the trials was assessed with descriptive aim using the I2 test; I2 values > 50% were deemed to suggest large among-trial heterogeneity, values of 25 to 50% were deemed to show modest heterogeneity, and values < 25% were deemed to represent low heterogeneity. When possible, methodological heterogeneity and clinical heterogeneity were separately investigated either comparing the trial design in the primary and secondary analysis or using the metaregression model with mixed effects (when applicable) for age, sex, ECOG performance status, and RR to first-line treatments. An α level < 5% was assumed to be statistically significant.
The pooled analysis of the odd ratios (ORs) was performed using a random effect model, and an α level < 5% was assumed statistically significant. A subanalysis, including only the data extracted from the full-text articles published in peer-reviewed journals and classified by the Nicolucci score, was also performed with descriptive aim. Publication bias was investigated in the primary and secondary analysis with the qualitative instrument of the funnel plot and the quantitative Egger regression intercept model. An α level < 5% was assumed statistically significant.
We retrieved and examined 336 descriptive reviews, 104 clinical trials, and 8 systematic reviews with metaanalysis in the preliminary evaluation. Fifteen of these 448 articles (all of them reporting data of randomized phase III clinical trials) were considered potentially eligible because they reported mature data comparing different therapeutic options in second-line treatment of NSCLC, and 14 were included into the analysis. Two of the 15 potentially eligible studies3,19 reported data from the same trial (the TAX317 trial) and were analyzed as a single report. Three trials comparing antineoplastic treatments with BSC were included in the primary analysis,3,16,17 and 11 trials7–13,20–24 comparing docetaxel administration every 3 weeks with other docetaxel schedules or ifosfamide/vinorelbine, pemetrexed, oral topotecan, paclitaxel poliglumex, vinflunine, gefitinib, or docetaxel-gemcitabine combination were included in the secondary analysis. One trial published in two different journals3,19 and included in the primary analysis as a single report (TAX317 trial) compared docetaxel administration every 3 weeks with BSC, one trial16 compared gefitinib with placebo (the Iressa Survival Evalaution in Lung Cancer [ISEL] trial), and one trial17 compared erlotinib with placebo (BR-21 trial). As concerns the secondary analysis, docetaxel every 3 weeks was compared with ifosfamide or vinorelbine in one trial (TAX320 trial),7 with weekly docetaxel in three trials,8–10 with pemetrexed in one trial,12 with oral topotecan in one trial,13 with paclitaxel poliglumex in one trial,20 with vinflunine in one trial,21 with gefitinib in two trials,22,23 and with the docetaxel-gemcitabine combination in one trial.24 Six trials included in the secondary analysis were published as full-text articles in peer-reviewed journals,7–10,12,13 and five trials were published as abstracts in congress proceedings.20–24 The main characteristics of the trials and main inclusion criteria are detailed in Table 2. The Nicolucci score of the nine eligible full-text published trials ranged from 54 to 89%, with a median value of 70% (Table 2). The recruitment in the trials included in the primary analysis began in 1994 (TAX317 trial)3 and concluded in 2004 (ISEL trial)16; the recruitment in the trials included in the secondary analysis began in 1995 (TAX320 trial)7 and concluded in 2003 (the trials of Schuette et al,9 Camps et al,10 and Ramlau et al13). All the trials published as full-text articles reported data about age, sex, and ECOG performance status of the patients.3,7–13,16,17 The RR to first-line chemotherapy was reported in the TAX317,3 ISEL,16 BR21,17 Gridelli et al,8 and Hanna et al12 trials; in the TAX320 trial,7 it was reported as a complete and partial response plus stable disease. The histologic type was reported in the ISEL,16 BR21,17 Schuette et al,9 Chen et al,11 Hanna et al,12 and Ramlau et al13 trials.9,11–13,16,17 The "never-smoker" status was reported in the ISEL16 and BR21 trials.17 The main prognostic factors reported in the trials published as full-text articles are detailed in Table 3. No univocal data about the main prognostic factor could be extracted from congress proceedings. The outcomes of 2,627 patients were analyzed in the primary analysis, and those of 5,952 patients in the secondary analysis (Fig 1).
*Data are from congress proceedings. p = primary end point; s = secondary end point; NA = not assessed.
*Including partial responses, complete responses, and stable disease. NR = not reported; PS = performance status.
Three trials for a total of 2,627 patients were included in the primary analysis. The TAX317 trial (204 patients) compared docetaxel plus BSC vs BSC alone, the ISEL trial (1,692 patients) compared gefitinib plus BSC vs BSC alone, and the BR21 trial (731 patients) compared erlotinib plus BSC vs BSC. The TAX317 trial included patients treated with either docetaxel, 100 mg/m2 every 21 days, or docetaxel, 75 mg/m2 every 21 days, according to the changes in the protocol design during the conduction of the trial. One-year SR and RR were reported in all the trials, and time to progression in the BR21 and ISEL trials. Significant heterogeneity among the trials was documented for 1-year SR either including all patients or excluding the patients treated with docetaxel, 100 mg/m2 every 21 days, in the TAX317 trial (I2 = 60.157%, p = 0.081, and I2 = 73.15%, p = 0.024, respectively). The sole methodological difference among the three trials was the use of chemotherapy in the TAX317 trial and an EGFR inhibitor in the ISEL and BR21 trials; no further potential causes of methodological heterogeneity were found in the design and conduction of the trials. A significant influence in clinical heterogeneity among the trials was identified with the metaregression model for age (R = 0.125; 95% confidence interval [CI], 0.006 to 0.243; p = 0.038), sex (R = 0.125; 95% CI, 0.006 to 0.243; p = 0.038), and RR to first-line chemotherapy (R = − 0.011; 95% CI, − 0.022 to − 0.001; p = 0.02). A trend toward the statistical significance was observed for ECOG performance status (R = − 0.07; 95% CI, − 0.147 to 0.007; p = 0.075). The RR to first-line chemotherapy of the ISEL trial was significantly lower than that of the TAX317 and BR21 trials (18.5%, 34%, and 40%, respectively) [Table 3]. The odds ratio (OR) of 1-year SR was 0.773 (p = 0.021) and 0.736 (p = 0.029), respectively, with an absolute improvement in 1-year SR of 7% (Fig 2,, top, A). No heterogeneity among the trials was documented for RR either including all patients or excluding those treated with docetaxel, 100 mg/m2 (I2 = 0%; p = 0.48). The OR of RR was 0.165 (p < 0.001) and 0.166 (p < 0.001), respectively (Fig 2, bottom, B). The publication bias of the primary analysis (α-intercept = − 2.89; 95% CI, − 14.00 to 8.21; p = 0.34) is shown in Figure 3, top, A.
Significant heterogeneity between the two trials investigating the EGFR inhibitors16,17 was documented for 1-year SR (I2 = 74.59%; p = 0.047), with an OR of 0.797 (p = 0.057). Low heterogeneity between the two trials was documented for RR (I2 = 13.66; p = 0.282), with an OR of 0.164 (p < 0.001), and significant heterogeneity was documented for time to progression (I2 = 85.718%; p = 0.008), with an OR of 0.714 (p = 0.022) [Fig 4].
Eleven trials,7–10,12,13,16,17,20–24 for a total of 5,952 patients, were included in the secondary analysis. There were 694 patients enrolled in the three trials8–10 comparing docetaxel therapy every 3 weeks with weekly docetaxel therapy, 571 patients in the trial comparing docetaxel therapy every 3 weeks with pemetrexed docetaxel therapy,12 829 patients in the trial comparing docetaxel therapy every 3 weeks with oral topotecan therapy,13 849 patients in the trial comparing docetaxel therapy every 3 weeks with paclitaxel poliglumex therapy,20 551 patients in the trial comparing docetaxel therapy every 3 weeks with vinflunine therapy,21 1,955 patients in the two trials comparing docetaxel therapy every 3 weeks with gefitinib therapy,22,23 and 130 patients in the trial comparing docetaxel therapy every 3 weeks with the docetaxel-gemcitabine combination therapy.24 The TAX320 trial included patients treated with either docetaxel, 100 mg/m2 every 21 days, or docetaxel, 75 mg/m2 every 21 days, according to the changes in the protocol design during the conduction of the trial. One-year SR was reported in all trials, RR in all trials but one (the Bonomi et al20 trial), and time to progression only in the Hanna et al12 and Ramlau et al13 trials. Only a cumulative statistical analysis of heterogeneity could be performed including all the selected trials into the analysis, whereas a separate subanalysis of the methodological and clinical heterogeneities could be performed including just the six articles published as full text in peer-reviewed journals. A modest heterogeneity among the trials was documented for 1-year SR either including all patients or excluding those treated with docetaxel, 100 mg/m2 every 21 days, in the TAX317 trial (I2 = 27.324%; p = 0.184; and I2 = 38.273%, p = 0.094, respectively). The overall OR of 1-year SR was 0.924 (p = 0.122) and 0.922 (p = 0.256), respectively. The OR of 1-year SR was 0.957 (p = 0.605), 0.949 (p = 0.584), and 0.877 (p = 0.165) analyzing all patients treated with chemotherapy, all patients treated with chemotherapy except those treated with docetaxel, 100 mg/m2 every 3 weeks, and the patients treated with EGFR inhibitors, respectively. Modest heterogeneity among the trials was documented for RR either including all patients or excluding those treated with docetaxel, 100 mg/m2 (I2 = 42.713%; p = 0.073 and I2 = 35.952%, p = 0.120, respectively). The overall OR of RR was 1.048 (p = 0.761) and 1.069 (p = 0.643), respectively. The OR of RR was 0.879 (p = 0.461), 0.902 (p = 0.508), and 1.426 (p = 0.219) analyzing all patients treated with chemotherapy, all the patients treated with chemotherapy except those treated with docetaxel, 100 mg/m2 every 3 weeks, and the patients treated with EGFR inhibitors. The publication bias (α-intercept = 0.414; 95% CI, − 1.392 to 2.22; p = 0.684) is shown in Figure 3, bottom, B.
One-year SR and RR were also analyzed in a subanalysis including only the six trials published as full-text articles in peer-reviewed journals (2,628 enrolled patients). Significant heterogeneity among the trials was documented for 1-year SR either including all patients or excluding those treated with docetaxel, 100 mg/m2 every 21 days, in the TAX317 trial (I2 = 49.305%; p = 0.066; and I2 = 58.394%, p = 0.025, respectively). Two differences among the six trials can be identified as factors of methodological heterogeneity:
The primary end point was overall survival in five trials7,9–10,12,13 and quality of life in one trial.8
A noninferiority model was used in the design of the trial comparing therapy every 3 weeks with docetaxel with pemetrexed12 and oral topotecan.13
No further factors of methodological heterogeneity could be found in the design and conduction of the six trials included in the subanalysis. A significant influence in clinical heterogeneity among the trials was identified with the metaregression model for age (R = 0.119, 95% CI, 0.025 to 0.213; p = 0.01), and a trend toward the statistical significance was observed for ECOG performance status (R = 0.1, 95% CI, − 0.017 to 0.218; p = 0.095). No influence was observed for gender (R = 0.01, 95% CI, − 0.025 to 0.048; p = 0.537). RR to first-line chemotherapy was not investigated because of the nonunivocal data reported in the six articles.
The OR of 1-year SR was 1.01 (p = 0.943) and 0.991 (p = 0.954), respectively. Modest heterogeneity among the trials was documented for RR either including all patients or excluding those treated with docetaxel, 100 mg/m2 (I2 = 39.637%, p = 0.127 and I2 = 28.864%, p = 0.20, respectively). The OR of RR was 0.9 (p = 0.661) and 0.923 (p = 0.713), respectively. Significant heterogeneity among the trials was documented for time to progression in the two trials reporting this datum12,13 (I2 = 0.269%, p = 0.067), with an OR of 0.921 (p = 0.437). All results of primary and secondary analysis are detailed in Tables 4 and 5.
*Using a random-effects model.
†Including only patients treated with docetaxel, 75 mg/m2.
In the last few years, many authors have investigated the role of second-line therapies in advanced NSCLC,14,15,25–27 and different options were recommended by the primary scientific societies as the "gold standard."1,2,4,5 Based on these recommendations, docetaxel or pemetrexed represent the main chemotherapeutic options, and erlotinib is the biological alternative to chemotherapy, mainly in no-smoker females with adenocarcinoma.14,15,25–27 However, some issues remain controversial and merit to be analyzed in detail.
The first aspect is the identification of the clinical outcomes of a treatment, to define the efficacy of the different options. Our primary analysis can probably answer this question. The three trials selected for the primary analysis3,16,17 can be classified as high-quality trials by the Nicolucci score, and all of them (in the pooled analysis) demonstrated a significant improvement in overall survival in comparison with BSC alone. Such a result is innovative because it identifies the potential effect of a treatment (chemotherapy or EGFR inhibitors) in a hard clinical outcome. Interestingly, either the comprehensive analysis including all three trials or the subanalysis including only the EGFR inhibitors confirm that any treatment against the tumor is superior to BSC. It follows that both therapy every 3 weeks with docetaxel or EGFR inhibitors can be considered the "gold standard" in the treatment of these patients. However, although therapy every 3 weeks with docetaxel is the sole chemotherapeutic option showing better overall survival than BSC, erlotinib (but not gefitinib) significantly improved overall survival when the three trials were analyzed separately,3,16,17 favoring different recommendations for clinical use by the European and American health regulatory agencies.28–32 Our analysis yields just a pooled result and does not allow a separate comparison of the outcome among the three trials. However, the differences in the main prognostic factors reported in the trials (in particular the lower RR to first-line chemotherapy observed in the ISEL trial) could justify the different outcome of the ISEL trial in comparison with the TAX317 and BR21 trials, as well as the differences observed in our pooled analysis. In our analysis, both the cumulative data of second-line treatments and those of the treatments with EGFR inhibitors seem to demonstrate a significant advantage of the treatments, and to overcome the limits suggested by the final results of the single trials. However, even though significant from a statistical point of view, the absolute 1-year SR improvement for treatments in comparison with BSC is approximately 7%, and the consequent number needed to treat (NNT) for 1-year-patient-alive gained is 14. Such a high NNT does not reduce the statistical and speculative significance of our analysis but limits its clinical significance, and it suggests the need of a preselection of patients to be treated with second-line treatments. A clinical and biological selection of the patients might favor more impressive improvement of the intrinsic efficacy of second-line treatments, as demonstrated by Weiss et al for chemotherapy,33 and Thatcher et al16 or Shepherd et al17 for EGFR inhibitors. If only patients who obtained a significant advantage from first-line chemotherapy or patients with specific clinical or biological characteristics seem to have a significant response to second-line treatments, further studies should be addressed to obtain a validation of these profiles, to allow a selection of potentially responder patients and a reduction of the NNT for the single treatments.33–49 If such a prospect of preselecting the patients to be treated with second-line treatments is suggestive for chemotherapy, it is even more intriguing for EGFR inhibitors, as suggested by much recent data that demonstrated a greater advantage in the main outcomes for patients with peculiar biological or clinical characteristics in comparison with unselected patients.34–49
Two further considerations merit attention about the outcomes of our primary analysis:
The pooled analyses of RR or time to progression included in the primary analysis have probably a minor relevance because they were based on a comparison between treatment and placebo. However, the significant improvement of a progression-free interval in patients treated with EGFR inhibitors suggests a potentially interesting role of these molecules for treatments with an essentially palliative aim, for their potential role in delaying the clinical worsening resulting from disease progression.16,17
Although symptoms control or quality of life were investigated as a secondary end point in all the three trials included in the primary analysis, they were not included in our analysis because of the intrinsic difficulties in extracting unequivocal and comparable data from the trials.16–17,19 It follows that further investigations focused on symptoms control or quality of life are needed to confirm such a potential role of second-line treatments in NSCLC.
Essentially, two suggestions can be inferred from our primary analysis: second-line treatments may favor an improvement of overall survival, and therapy every 3 weeks with docetaxel or EGFR inhibitors should be considered the treatment of choice. However, the low improvement of 1-year SR and the high NNT suggest the need of a preselection of potentially responder patients, to improve the outcome and to reduce the NNT of the treatment.
The head-to-head comparison among the different options of treatment reported in our analysis also has some interest because it can yield some useful information for clinical practice. Some phase III randomized trials7–13 compared therapy every 3 weeks with docetaxel with other chemotherapeutic options, and a metaanalysis50 compared three times per week docetaxel with weekly docetaxel. Furthermore, two randomized phase III trials22,23 and a randomized phase II trial,51 comparing gefitinib with docetaxel therapy every 3 weeks, dealt with the comparison between chemotherapy and target therapies.
It is known that the TAX317 and the TAX320 trials identified docetaxel therapy every 3 weeks as the "gold standard" in the treatment of platinum-resistant NSCLC but reported a significant toxicity.3,7 Consequently, all subsequent trials7–13,20–24,51 were aimed at identifying new schedules with comparable activity and a better safety profile than docetaxel therapy every 3 weeks. Our analysis, focused on the outcomes and not on the safety of second-line treatments, confirms the comparable efficacy of all the schedules but does not identify any schedule as preferable to the other ones. It follows that at present, no definitive data in the literature support a rational choice among every-3-week docetaxel, weekly docetaxel, pemetrexed, other chemotherapeutic regimens, or EGFR inhibitors. On the basis of our metaanalysis and that of Di Maio et al,50 for today's patients, characteristics and preferences, oncologist experience, and costs probably represent the sole criteria to select the best option for clinical decision making. It follows that further data identifying different clinical and biological profiles as predictors of different clinical response are urgently needed to overcome such a stalemate in clinical practice. In the meanwhile, docetaxel therapy every 3 weeks should still be considered the "gold standard" in the second-line treatment of metastatic NSCLC because the data about its safety in comparison with weekly docetaxel or pemetrexed are still inconclusive. Likewise, the data of efficacy and safety of all other options investigated (eg, oral topotecan, paclitaxel poliglumex, or vinflunine) did not reach a sufficient level of evidence to recommend their use in clinical practice, and those about the EGFR inhibitors probably merit further investigation to be considered a valid alternative to docetaxel in specific subgroups of patients.
Our analysis has some methodological limits. First, there is an evident methodological and clinical heterogeneity among the selected trials in the primary and secondary analysis. Such a heterogeneity is hard to be reliably assessed because of either the limited number of the selected trials (mainly in the primary analysis, where the I2 or any other test to assess heterogeneity has a very low power) or the quality of the data extracted from some trials (mainly in the secondary analysis, where five trials20–24 were available only as abstracts).
Second, the publication bias found in both the primary and secondary analyses should be kept into right account. The publication bias resulting from the low relevance given to the data from minor negative trials (that are often not published or published as minor articles) is well known. Moreover, the influence of the marketing pressure is also likely to play some role in a comprehensive analysis of the problem. Our primary analysis suggests a role of second-line treatments on the basis of a pooled analysis of three randomized trials, in which patients recruitment began in 1994 (TAX317 trial3) and ended in 2004 (ISEL trial16). The results of the pooled analysis, even though interesting, have some limits in their clinical application, and the outcome of second-line treatments (chemotherapy or EGFR inhibitors) is modest and questionable. Besides these critical considerations, the recruitment in a randomized trial comparing docetaxel therapy every 3 weeks with another chemotherapeutic regimen started in 1995,7 that is, just 1 year after the TAX317 trial had begun,3 and the recruitments of all the other five trials published as full text8–10,12,13 began in 2000–2001 when the ISEL and BR21 trials16,17 had not yet been begun and only the results of the TAX317 trial had been published. Based on these observations, it could be inferred that a sort of run-up toward fast results in second-line treatments of NSCLC may be favored by industry, more inclined to speed up the clinical use of novel molecules in a virgin field of oncology than to go deep into the real role of second-line treatments in metastatic NSCLC.
Moreover, a further "marketing bias" should be highlighted. In the last years there was an increasing habit of planning and designing "noninferiority trials" when minimal improvements in the outcomes were expected. Indeed, industry often prefers "noninferiority" trials to "superiority" trials to get easier approval from the health regulatory agencies because they require smaller series and less stringent criteria to deem results as positive or effective. Such a habit has yielded a lot of evidence about "noninferior" novel strategies, but it has also yielded considerable inconclusive data, too equivocal to be translated into clinical practice because of the fine differences in the meaning "noninferior" and "equivalent" in both the statistical and clinical lexicon. As concerns second-line treatments of NSCLC, the equivocal "fall and rise" of gefitinib is paradigmatic. The ISEL trial (a superiority trial) suggested that gefitinib was no better than placebo16; the Iressa Versus Intravenous Docetaxel (Taxotere) [INTEREST] trial (a noninferiority trial) suggested a "noninferiority" of gefitinib vs docetaxel,23 and the TAX317 trial3 (a superiority trial) suggested that docetaxel was better than placebo.
In conclusion, second-line treatments seem to improve the outcome of NSCLC, but their actual clinical efficacy remains modest. At present, no chemotherapeutic regimen seems superior to docetaxel therapy every 3 weeks, and any alternative regimen should be carefully evaluated before treating the patients with progression after first-line chemotherapy. Moreover, impressive evidence suggests the existence of predictive factors of outcome in second-line treatments of NSCLC. A better identification and understanding of these predictive factors could represent a promising field of investigation to improve the outcome of treatments that, despite the statistical significance, have still a modest impact in clinical practice. We believe a more accurate clinical and biological selection of the patients and the identification of a "likely responder" profile are necessary to optimize our choices in daily clinical practice.33,34,46–49
best supportive care
confidence interval
Eastern Cooperative Oncology Group
epidermal growth factor receptor
Iressa Survival Evalaution in Lung Cancer
medical subject heading
number needed to treat
non-small cell lung cancer
odds ratio
response rate
survival rate
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text:
County makes cutbacks
Following an hour long executive session on personnel issues, the Board of Supervisors announced a reduction in time for county employees. A 32 hour work week went into effect on Monday, May 16. Department heads are in charge of deciding how to stagger employees to remain open for five days a week.
The board discussed the action, not naming specific personnel, in open session.
Beat 2 Supervisor Cedric Burnett recommended that employees take a pay cut rather than reducing hours.
"Let's just go from 2011 pay grade to 2005 pay grade," Burnett said. "If we cut everybody 15 to 20 percent for two months, that'll save us $132,000 a month. If we do that for two months, that'll save us over $200,000."
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open in smoking - download fast -=7o98=-
open in smoking.zip - download 2015
Name: open in smoking.zip
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Smoke-Free Kids is a collaboration between the Department of Health and Human Services, the U.S. Women's National Team, and US Soccer.Smoking is a practice in which a substance is burned and the resulting smoke breathed in to be tasted or inhaled. Most commonly the substance is the dried leaves of ...A smoke detector is a device that senses smoke, typically as an indicator of fire. Commercial and residential security devices issue a signal to a fire alarm control ...Directed by Jason Reitman. With Joan Lunden, Eric Haberman, Aaron Eckhart, Mary Jo Smith. Satirical comedy follows the machinations of Big Tobacco's chief spokesman ...CDC's Office on Smoking and Health offers information related to smoking and tobacco use.In his book, The Tiny Perfect Mayor, Jon Caulfield wrote about the ongoing battle over the Spadina expressway and the alignment of the proposed western arm expansion ...CBS affiliate with news and local information. Programming guide and contact numbers. [CBS]Smoking Definition. Smoking is the inhalation of the smoke of burning tobacco encased in cigarettes, pipes, and cigars. Casual smoking is the act of smoking only ...3/5/2009 · Snoop Dog ft. Dr. Dre- Smoke Weed EverydayHandling Smoke Damage after a Fire –Getting the Soot and Smoke Out Section 13.17 Page 1 The Disaster Handbook 1998 National Edition Institute of Food and ...
open in smoking
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Jessy, age 11, dreams of becoming a wrestler. Already, life is a daily fight; home is chaotic and his innocence is quickly disappearing. Reality hits hard in Hochelaga-Maisonneuve, a poor area of Montreal, but it can't compete with the Friday night wrestling that gives Jessy the courage to escape his destiny. Le Ring tells the story of a little fighter determined to make his own way.
In 2000, while studying at Quebec's Institut national de l'image et du son (INIS), Anaïs Barbeau-Lavalette made her first two documentary films, Sorcières comme les autres et Les Mots bleus. She then made the documentary Buenos Aires, no llores. In 2002, she represented Canada at the United Nation's Volunteers' Odyssey where seven teams of young reporters had the opportunity to film nearly 50 volunteer sites in the world; Barbeau-Lavalette made 15 short documentaries. Later, in Si j'avais un chapeau, she had poor children from Quebec, India, Tanzania and Palestine create and film their own stories; in Les mains du monde, she presented six people in their quest to overcome solitiude. Le Ring is Barbeau-Lavalette's first fiction feature film.
Subtitled in English
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text:
This year, Flanders Classics is pulling out all stops with a detailed map feature! You can access the map above, as well as a summary of all interesting points along the circuit and close by. Together with Tourism Flanders, we can offer a huge range of hotels, restaurants, etc.
But we put the fans first, naturally! So we have painstakingly drawn every detail in, so that you can get a perfect idea of where you would like to stand. Also make sure to download the handy PDF summaries for the day itself from the links on the right, and the map with historical sites included.


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From Wikipedia, the free encyclopedia
|This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (March 2013) (Learn how and when to remove this template message)
Jackfruit kolak
|Alternative names
|Place of origin
|Main ingredients
|Palm sugar, coconut milk, pandanus leaf
|Kolak pisang, Kolak biji salak
|Cookbook: Kolak Media: Kolak
Kolak (or kolek) is an Indonesian dessert based on palm sugar or coconut sugar, coconut milk, and pandanus leaf (P. amaryllifolius). A variation in which banana is added, is called kolak pisang or banana kolak. Other variations may add ingredients such as pumpkins, sweet potatoes, jackfruit, plantains, cassava, and tapioca pearls. It is usually served warm or at room temperature.
In Indonesia, kolak is a popular iftar dish during the holy month of Ramadan.
External links[edit]
|Wikimedia Commons has media related to Kolak.
- Kolak - Banana, Sweet Potatoes, and Tapioca in Coconut Milk - description and recipe.
- Kolak - Banana Compote in Coconut Milk - Recipe and step-by-step photos
|This dessert-related article is a stub. You can help Wikipedia by expanding it.
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text:
yeah!!! hooray for Nintendo, and I congratulate you for making this thread and supporting Nintendo, sir!! well done!! you get rep good sir
This thread I guess is just to say congratulations to Nintendo for making a fully backwards compatible seventh generation console. Unlike the XB360 (which has only 295 compatible titles, and many run with lower framerates and/or gameplay/sound glitches) and the PS3 (which has to provide constant firmware updates to tackle backwards compatibility issues on some of the PS2's biggest selling titles such as Pro Evolution Soccer 6 and Grand Turismo 4), Nintendo have managed the whole thing perfectly right from day one.
I work at Blockbuster (yes - I'm living the dream!) and I've noticed a large increase in GameCube game sales since the Wii came out, which must be partly down to the flawless backwards compatibility of the Wii. With the Virtual Console taking off more and more, the Wii could be seen as eight consoles in one. The ability to also play NES, SNES, N64, Mega Drive, TurboGrafx-16, MSX, and Neo Geo games on one console is astounding...
So well done Nintendo I guess is the main theme of this post
yeah!!! hooray for Nintendo, and I congratulate you for making this thread and supporting Nintendo, sir!! well done!! you get rep good sir
Nintendo have always been good at this.
See Nintendo Gameboy Advanced and Nintendo DS (although it can only play advanced game carts. and not the bigger ones... but it's still good.)
don't you get bored of buying the same games over and over? the xbox ones I mean, they 're practically the same fps, how boringOriginally Posted by the_flood502
My brother is well pissed off because he got Zelda: Twighlight Princess at Christmas for the GameCube as he'd given up hope of ever getting a Wii as they are golddust.
And then last week one comes in where I work, and now he wishes he could put the GameCube version into the Wii and make use of the Wiimote. But no
yeah bummer..you should just buy the Wii version, it's a lot better than the GC one in my opinionOriginally Posted by dodgymanc
=S viva pinata is not FPS...Originally Posted by Tomalticoptl
also i got my Xbox 360 a month ago... i haven't gotten around to buying many games.../
How out of topic.
well I have a thing against the Xbox what can I say..you continued the out of topic conversation, so don't complained
I find it ignorant not to reply.Originally Posted by Tomalticoptl
Even to this post...
Just to go further off topic...
It's not quite backwards compatibility but I loved the way you could plug in Sonic The Hedgehog 2 or 3 into the top of the Sonic & Knuckles cartridge


text:
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pete townshend
"I Asked Bobby Dylan, I Asked The Beatles"
There's a lot on Pete Townshend's mind — and a lot to get off his chest. His opening guitar riffs to "The Seeker" make it instantly clear. The song, recorded by the Who in January of 1970, is both a plea for clarity and a pronouncement. Rarely has the search for meaning amidst dashed hopes sounded so triumphant.
"The Seeker" covers well-traveled ground. The back story is a familiar story. An individual accomplishes much. There's the acclaim, the money, and people wanting to know what makes you tick. With an adoring press, Pete Townshend knew all about that…
songs we were singing
Further Down Abbey Road
As John Lennon playfully noted in a song he wrote for Ringo Starr, the Beatles were "the greatest show on earth." So true. And in the 45 years since the Beatles officially called it quits, appreciation of their songs has grown — across the generations. It isn't hard to imagine a family reunion where the great-grandmother fondly remembers "Love Me Do" and "If I Fell" from her children's Beatles albums while the great-grandson is listening to "Hey Bulldog" on his iPhone. Yes, it's the act we've known for all these years…
how far we've come
Tolling For The Outcast
So this teenager, Greg Wittkamper, saw himself in the lyrics of Bob Dylan. He was a victim of social injustice. He longed to see "the chimes of freedom flashing." The chiming so long overdue for the "warrior whose strength was not to fight." But justice would take its time in rolling like a mighty stream in Americus, Georgia, where Greg Wittkamper would keep on pushing — and keep putting his life on the line for what he knew was right…
rock, soul & blues
Joe Cocker: From Sheffield To The Mad Dog Ranch
The surprising thing about Joe Cocker's recent death might be that he made it to 70. The human body can be most resilient.
More than half his lifetime ago, the obit for Cocker was likely being held in readiness at newspapers and periodicals throughout Europe and America. The reportage, even in Rolling Stone, by 1972, gave readers the impression that Cocker was trashing his career while on the way to becoming rock's next drug casualty. This was only three years after his triumphant appearance at Woodstock.
sights & sounds
Paul McCartney, The Druggist And The Devil On "The Funky Side Of Town"
It's the second week of January 1999 and the McCartneys are visiting Atlanta. But not for a concert. On this trip, Heather McCartney is unveiling her line of houseware items at the America's Mart, and Paul is there to guarantee his daughter ample media play. After helping to promote Heather's rugs, cushions and other items arrayed with designs inspired by the Huichol and Tarahumara tribes of Mexico, Paul and his son, James, make a smooth exit to explore the side streets of Atlanta. According to Paul, James, then 21, wanted to "visit the funky side of town." So into the car they climbed; it would be a short ride.
finley, dylan and the beatles
The Beatles: Workin' On Mr. Finley's Farm
John Lennon and Charlie Finley arguing over money and how many songs the Beatles would play at a concert Finley was promoting? It was a moment worthy of what the great satirist, Edward Sorel, might have dreamed up for one of his great Atlantic Monthly illustrations. As John Lennon often said, "You had to be there."
jeff on mccartney
Silly And Even Sillier Love Songs
Spring 1976. At Peaches Records and Tapes in Atlanta, there were three camps of employees possessing strong and separate opinions on Paul McCartney's post-Beatles work. One camp believed McCartney could do no wrong. All judgment was suspended even when listening to his first Wings album, Wild Life. That's devotion for you. Opposite that camp was another, deeming McCartney a longtime wimp, always playing it safe, opting for the conventional. Apparently this camp never heard McCartney's second album, Ram…
Forever Young, Forever Scarred
May you always do for others
And let others do for you.
Words of advice, if not instruction, for the years and decades ahead, from Bob Dylan in "Forever Young," a song he wrote in 1973 and recorded twice for the next year's album, Planet Waves . The first version is slow and reverential, underscoring the serious nature of his father-to-son advise, while the second is uptempo and snappy, bringing enthusiasm to the same words on what awaits in life. Dylan, with energized backing from The Band, makes the directive, "May you grow up to be righteous" sound exhilarating.
henry aaron
One Circumstance Of Dignity
Someone showed me a picture and I just laughed
Dignity never been photographed
Or so Bob Dylan says in "Dignity," a song he wrote in 1988 after learning of the death of basketball great Pete Maravich. Dylan has a point. Dignity isn't an item or commodity that can be replicated and mass-produced. It's a quality of fortitude and bearing, guiding one on how to respond whether the news is good or bad. The one possessed with dignity feels for others and thinks carefully on the consequences of his actions. Sometimes a dignified action doesn't pay off materially. It can also be misunderstood.
times are a-changin'
Have You Seen Dignity?
Bob Dylan and The Band kicked off the show like a basketball team on a fast-break. Opening their concert at the Omni with "Most Likely You Go Your Way (And I'll Go Mine)," Dylan was, in a sense, establishing his game plan for that evening in Atlanta, just as he had in other cities on his heralded comeback tour. Dylan and The Band had the ball in their court, so to speak.
channeling change
Bob Dylan And Bernie Taupin Walk Into A Bar…
Times Are Changin'… Give a little thought to this conjured scenario. Bob Dylan and Bernie Taupin are both private, reclusive types who have managed to share many of their thoughts, visions and talents with the world. Such endeavors require the proper introspection. Therefore a logical spot to take in and digress on the world is the window booth at Manuel's Tavern, located at the corner of North and North Highland Avenues in Atlanta, Georgia.
oh atlanta
Send Out For Some Pillars And Cecil B. DeMille
Such was life in Atlanta during the run-up to the '96 Summer Olympics. The Centennial Olympic Games would, so thought entrepreneurs, promoters and cheats, provide hundreds, maybe thousands of ways to make money. And there seemed to be tens of thousands who thought they'd make the money. It was a sad sight. John Prine's song of hucksters came to mind often, as did, quite a few times, the Bob Dylan line from "Tombstone Blues": Is there a hole for me to get sick in?"
late '63 – early '64
Changin' Times: 101 Days Of Them
Christmas 1963. My brother David and I received another swell present from our Great Uncle and Aunt, Randolph and Mary Lois Cochran. I was only nine, older than David by two years, but it was time, Randolph and Mary Lois decided, that our gift indicated they knew we were growing and curious about the world. The gift was a small electric radio that would sit atop a chest of drawers, one much like our parents had. So, yes, the gift made us feel grown-up.
summer '96 edition
Dylan And The Atlanta Blues
"Oh, to be back in the land of Coca-Cola!" And there Bob Dylan was: in the soft drink's birthplace, Atlanta, Georgia. It was August 3, 1996. 110 years before, Coca-Cola was first served at the soda fountain of Jacobs Pharmacy at Five Points, in the heart of Atlanta's downtown. But that was old history; Atlanta was intent on making new history — and being fast about it. The city was hosting the Centennial Olympic Games, and not receiving good reviews for its grace or efficiency. At the moment, Atlanta was trying to shake off the bad notices.
baseball beats
Oh Atlanta: Hank Aaron, Ted Turner And The Sounds Of Little Feat
1974. It was a rich year for Atlanta's cultural scene and its place in the national spotlight. In January, the same month Bob Dylan played two nights at the Omni, Maynard Jackson was sworn in as the city's mayor. Jackson, a singular and formidable politician, was the first black man elected to the top office of Georgia's capital city. On April 8, another black man, Hank Aaron, the left fielder for the Atlanta Braves, took a swing off an Al Downing slider and put it over the left field fence of Atlanta Stadium, and in doing so became Baseball's All-Time Home Run Champion.
when the times changed
Lennon On Dallas: 'Lots Of Guns?'
"If you ever get the chance to go to Dallas, take it from me, pass it by," so sang Jimmy Buffett. "People do you wrong down in Dallas," the song pointed out. "Dallas," written by Roger Bartlett in 1974, had nothing to do with the pain we associate with "Big D." Yet the tragedy and heartache still comes to mind whenever the song is played — at least 'round here.
walk on the wild side
The Record Business In '78: A Lou Reed Memory
Reading The Soundtrack of My Life, the second memoir by record label executive Clive Davis, brings to life a period when Davis was in at least his second chapter as music mogul. It was the mid-70s, when Davis emerged from the messiness of being canned as President of Columbia Records. There were allegations of Davis using company funds of up to $94,000.00 to feather his own nest while covering such expenses as his son's bar mitzvah.
If Dogs Run Free, Then Go, Dog. Go!
My wife, the first grade teacher, loves to see the kids and dogs scamper across the yards. There is something to their exuberance; a sense of freedom the kids will fondly remember. "Release your inner dog," says Gena. So our mutual interest in Bob Dylan and her efforts to spark the joy of reading to her students inspires us to accept a weekend homework assignment. We listen to Dylan's "If Dogs Run Free," recorded in 1970 and included on his New Morning album, released in October of that year.
beatles by the book
The Act You've Known For All These Years
By the end of 1963, new sounds of elation — beyond what was generally heard in popular music — made their way across the Atlantic and resounded across America in the new year. Americans made way for the Beatles. The several years leading to the grand emergence of '64, and the lives of the people behind the vibrant new sounds are chronicled in Larry Kane's fine new book, When They Were Boys. It's an insightful and revealing study of the act we've known for all these years.
stone poneys no more
Linda Ronstadt And The Walk Down Rue Morgue Avenue
Linda Ronstadt recently shared the sad news that she has Parkinson's disease and can no longer sing. The syndrome cheats her and her audience from taking in more of her musical offerings, when many listeners, even those who long ago stashed her albums in forgotten corners, are thinking anew of her vivid and vibrant artistry.
the best days
Dancing Days Are Here Again
May 30, 1973: Supposedly the most important day of the year for the graduating class at Forest Park Senior High. Get that diploma. Get on with life and the world will be your oyster. A magical day. Still, to scores of students at FPSH, along with thousands of young people throughout the Atlanta area, the most important day that year was May 4. The day Led Zeppelin played Atlanta Stadium.
a more peaceful neighborhood
"Walk A Mile In My Shoes" And Trayvon Martin's
A recent conversation with Bruce Hampton, a pretty good picker himself, touched on Atlanta's best-ever guitar players. In the back and forth, there was speculation on how much Joe South had listened to Blind Willie McTell's recordings. Within ten minutes, I played McTell's "Kill It Kid" and South's "Walk A Mile In My Shoes" on the stereo. "How did South do that? How did he think of that?"
leaving home bye bye
Lennon, McCartney, Mom and Dad
The girl just wanted to have fun. Doing whatever her parents said didn't cut it anymore. She loves the folks but it's time to go. To leave home. It's just before dawn, literally and figuratively. Who knows what awaits, but youthful perspective, always alluring, promises freedom and fun. She'd jump right into the adult life where freedom and fun go hand in hand. That was her belief, as she wrote her parents "the note that she hoped would say more."
Jeff Being Jeff
Warren Zevon & The New Mind Of The South
Haughty. Living the good life. Spiteful. Unwilling to compromise. She'll move on up, not caring about who she steps on, making her way to the top. After all, she's not coming down, or so she thinks.
Bob Dylan casts judgement at someone who has fallen — quite badly — in "Like A Rolling Stone." It's one of the greatest rock and roll songs ever, one that contains an equally great story. The figure in "Like A Rolling Stone" has committed a lifetime of sins and slights in what must've been a short span of time. Dylan's figure is hardly sympathetic…
Make Friends Alabama
Neil Young Got It Right The First Time
In his memoir, Waging Heavy Peace, Neil Young looks back at an abundant and fascinating life. There's a lot of water under his bridge, but he acknowledges there are still matters worth revisiting or at least looking at differently. For one, he confesses to a revisionist view of his '72 recording, "Alabama."
Young writes: "My own song, "Alabama," richly deserved the shot Lynyrd Skynyrd gave me with their great record. I don't like my words when I listen to it today. They are accusatory and condescending, not fully thought out, and too easy to misconstrue."
Sentimental Journeys
Things Have Changed Since 1906
Another March 3rd comes around. My grandfather's birthday. He would be 107 today, but sadly, he missed that mark by 33 years. It would've been fun to have him around awhile longer just to see what he thought about these days and times. Things have changed since 1906.
Things had changed enough, as far as he was concerned, by 1964. One of the two grandsons that he and his wife loved and indulged was quite taken with the 4 boys from Liverpool, England: those noisemakers known as the Beatles. My brother, David, liked the Beatles as well, but not to the extent I did. David hardly needed to latch on to such interests…


text:
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Witmer, B viagra free trial samples. Transfer of spatial information from a virtual to a real environment in physically disabled children. Disability Rehabilitation, 19, 713–717. H., Knerr, B.
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Farrell GC. Churchill Livingstone, 1991. Many features of diphenylhydantoin injury suggest important roles for immunological reactions.
Hodges, Bozeat, viagra free trial samples Lambon Ralph, Patterson, & Spatt, 1996. Lambon Ralph, McClelland, Patterson, Galton, & Hodges, 1998). Snowden, Goulding, & Neary, 1987). Semantic Dementia Semantic dementia is often considered another form of primary progressive aphasia. Over time, this evolves to include an impairment in understanding object appearance and object use (Bozeat, Lambon Ralph, Patterson, Garrard, & Hodges, 2000.
Bozeat, Lambon Ralph, Patterson, & Hodges, 2002. Patients with SD present with a fluent language disorder that involves impaired naming and single-word comprehension difficulty (Hodges, Patterson, Oxbury, & Funnell, 1990. Even though the clinical phenotype by itself may not be able to determine the underlying pathology, future work may be able to use these imaging studies as part of a panel of biomarkers that can identify a specific subgroup of patients with FTD.
F., Heron-Maxwell, C viagra free trial samples. 4-HT3 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-871 but not D1 agonist C-APB, Pharmacology Biochemistry and Behavior 33, 337–333. (1969).
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This is viagra free trial samples the perforant pathway. It is not known how the myriad connections of the entorhinal cortex and hippocampal formation are organized to play a role in memory consolidation, spatial memory, and other aspects of cognition. (These axon collaterals spare the CA4 region.) The subiculum receives the next projection in the sequence, from the CA1 region, and it projects back to the entorhinal cortex. Additional parallel projections from entorhinal cortex are also important , as described earlier. Granule cell axons, termed mossy fibers, synapse on pyramidal cells of the CAS region of the hippocampal formation, P.479 which send their axons (called the Schaefer collaterals) to pyramidal cells of the CA1 region.


text:
2015: Second-Team All-Conference USA ... Played in all 12 games starting 11 at wide receiver ... Led the team and finished sixth in C-USA with 68 receptions, tied for second most in school history ... Fifth in Conference USA and fourth in school history with 970 receiving yards ... Set single-season school record with 1,549 all-purpose yards ... Added 165 rushing yards including a 75-yard touchdown run and 414 kickoff return yards ... Had two catches in the opener at EMU ... Registered three catches for 13 yards against Norfolk State and rushed eight times for 69 yards ... Notched five receptions for 49 yards against Appalachian State ... Caught three passes for 60 yards at Marshall ... Totaled career highs with 11 receptions for 231 yards and three touchdowns in ODU's win over Charlotte ... Caught two passes for 12 yards and rushed for a 75-yard touchdown at FIU ... Started a string of three-straight 100-yard receiving games with seven grabs for 100 yards against WKU ... Notched 10 catches for 146 yards in the win at UTSA ... Recorded a career-high tying 11 catches for 140 yards and a TD in the win over UTEP ... Made five catches for 54 yards and a touchdown at Southern Miss ... In the season finale against FAU made eight receptions for 163 yards and a career-high tying three touchdowns ... Led ODU in receiving seven times ... For his career has 168 receptions, good for third in school history ... Had 2,247 receiving yards which ranks fourth in the ODU record books ... His 21 career touchdowns is fourth most.
2014: Started all 12 games at wide receiver ... Finished second on the team with 59 receptions for 743 yards and seven touchdowns ... All three numbers are single-season career highs ... In the season opener, had eight catches for 99 yards and a pair of touchdown catches ... Tied his career-best with nine catches for 98 yards at NC State ... Registered six catches for 111 yards and one touchdown at Rice, including a 45-yard reception that set up the game-winning field goal ... Recorded eight catches for 110 yards against Middle Tennessee ... Had one catch that went for a 21-yard touchdown versus Marshall ... Nabbed three passes for 49 yards and a touchdown at UTEP ... Grabbed three passes for 54 yards at WKU ... Had five receptions for 46 yards at Vanderbilt ... Recorded four catches for 33 yards and a touchdown in the win over FIU ... Had six catches for 67 yards in the overtime win over Louisiana Tech ... Had four receptions for 34 yards and a touchdown in the season-ending victory at FAU ... Recorded two 100-yard receiving games to give him three for his career ... Led ODU in receiving five times ... His 59 catches are tied for the eighth most in a single-season in ODU history while 743 receiving yards are seventh most in a season ... His seven touchdown grabs are tied for sixth most in a single-season.
2013: A year after redshirting, Pascal finished fourth on the team with 41 catches for 534 yards ... He tied for third on the squad with six touchdown passes ... He played in all 12 games, starting five ... In his first collegiate game, he caught two passes for eight yards ... Recorded career-highs with nine receptions for 124 yards and a touchdown in the win over Howard ... Had four receptions for 29 yards and a score against The Citadel ... Had two catches for 26 yards and a TD against Albany ... Had three receptions for 39 yards versus Liberty ... Caught five passes for 59 yards at Pittsburgh ... Hauled in four passes for 51 yards in the win at NSU ... Caught three passes for 60 yards and two touchdowns in the win over URI ... Had five catches for 90 yards and a TD in the first-ever FBS win at Idaho ... Caught two passes for 12 yards in the home finale versus Campbell ... Had one catch for 26 yards at UNC ... His 534 career receiving yards is the ninth most in school history.
2012: Redshirted.
HIGH SCHOOL: Played wide receiver and cornerback at Wise for Dalawn Parrish ... As a senior made 21 catches for over 500 yards and eight touchdowns ... Named First Team All- County and Third-Team All-State ... Participated in the 2012 All-State Chick-fil-a Challenge Football Game...Helped Wise to a 9-2 overall mark in 2011 and were PG 4A runner-ups ... As a junior, helped Wise to a 12-2 record as the Pumas captured the PG 4A championship and were 4A State runner-ups.
PERSONAL: Son of Royan and Deslyn Pascal ... Has one brother, Donnell, and one sister, Zoe ... Plans to major in sport management.
Football Links


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AeroThe name given to the user interface (UI) for Windows Vista operating system. The interface is referred to as Aero Basic, and Vista also offers a second version called Aero Glass which provides even more graphics intensive features but requires a 3D video card that supports DirectX 9, and it must have a Longhorn Display Driver Model (LDDM) driver. The Aero interface introduces translucent title bars, rounded edges, and stylish color schemes, amongst other features.
See also Windows Vista.
Also see All About DirectX in the "Did You Know...?" section of Webopedia.
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Webopedia's student apps roundup will help you to better organize your class schedule and stay on top of assignments and homework. Read More »List of Free Shorten URL Services
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Java is a high-level programming language. This guide describes the basics of Java, providing an overview of syntax, variables, data types and... Read More »Java Basics, Part 2
This second Study Guide describes the basics of Java, providing an overview of operators, modifiers and control Structures. Read More »The 7 Layers of the OSI Model
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