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Now that things have settled down a bit in Washington, D.C., do you think it will be business as usual?
It's a sad day when it isn't an option to answer that 'business as usual' for Congress entails some sort of legislating. Their raison d'être, likesay.
5 Agrees | 2 Disagrees | Report Abuse »
Corruption, destruction, stealing, lying, etc.... yeah business as usual.
5 Agrees | 1 Disagrees | Report Abuse »
No change until we can get a new president and reid and pelosi are gone from the left......Bonehead from the right needs to go as well.
We need term limits and since we are the people with the votes we need to vote people out when needed.
7 Agrees | 4 Disagrees | Report Abuse »
oops.. forgot gloom, despair and agony.
3 Agrees | 1 Disagrees | Report Abuse »
To use the word business in connection with Washington DC is a great insult to business owners. Change "business" to "party" would be more correct.
3 Agrees | 2 Disagrees | Report Abuse »
Veritas, I disagree with your post except for one point. I'd love it if the red-blooded American conservative minded patriots with good values and work ethic could be given a state like Texas. I'd move there, our society would prosper, and we'd watch the liberal society around us collapse upon itself.
5 Agrees | 8 Disagrees | Report Abuse »
Basically it will be the same, except, Obamacare: it fines you for not buying a product you don't want from a website that doesn't work.
4 Agrees | 4 Disagrees | Report Abuse »
Nope, wouldn't have to ban TV. As a really free society without a nanny-state government always thinking they know what's best for people, free from political correctness, we would understand that we can simply change the channel if we don't like watching libs, and those honey boo boo shows that turn ones brain to mush..
4 Agrees | 4 Disagrees | Report Abuse »
Obviously, Bob is blinded by his neon conservatism in considering a move to Texas. Probably some research on your part, Bob, would bring to light the shortcomings of that conservative state. Just like most of the red states, Texas is a welfare state on taxes, taking more out than they put in. More research will also show that Gov. Perry(he, of the no government money, etc), used federal money to balance the budget of Texas instead of putting it to good use for the people. He did all of this so he could bloviate while running for president. You should also check on the number of children and people without health care and the average wage of the general population. So, if you really want to go to Texas, don't let the door hit ya.
4 Agrees | 5 Disagrees | Report Abuse »
they are juvenile in ignoring history and continuing to think supply side economics or the theory of trickle down must be tried again."
Currently, our government is engaging in economic practices popularized by John Keynes, or "demand-side" economics. Keynesian economics is not all good....
3 Agrees | 3 Disagrees | Report Abuse »
Another criticism of the (Keynesian) theory is that it leans toward a centrally planned economy. If the government is expected to spend funds to thwart depressions, it is implied that the government knows what is best for the economy as a whole. This eliminates the effects of market forces on decision-making. This critique was popularized by economist Friedrich Hayek in his 1944 work, "The Road to Serfdom". In the forward to a German edition of Keynes' book, it is indicated that his approach might work best in a "totalitarian state".
How's your Saturday, fellow serfs?
3 Agrees | 4 Disagrees | Report Abuse »
"...neon conservatism..."
Where can I buy that? It would look cool in a window at night, maybe to advertise something, well, conservative.
3 Agrees | 3 Disagrees | Report Abuse »
PJinfinity: "This newspaper -- and the Republican party it represents -- is one, big, ugly joke."
Like Bob said, you're free to change the channel. As in yesterday.
4 Agrees | 4 Disagrees | Report Abuse »
See now this kind of thing is fun. Before you know it, we're splitting hairs over Texas being a good mecca for all things conservative and I've learned a new phrase "neon conservatism", although I'm not really tracking what that means. But please don't compare Honey Boo boo to yogi bear, Winnie the poo and Paula Dean. Those 3 were and still are quality television entertainment that is good for the American culture, stuff to raise your kids on, ya know? But Honey Boo Boo, that's just trash, along the lines of Rosanne, trash. Looking forward to the next political round of comments. Sorry if I hurt any libs feelings today, I know how sensitive ya'll can be.
4 Agrees | 6 Disagrees | Report Abuse »
Now is that more of the tolerant liberal-speak I keep hearing about?
Tolerance for some, not for all.
5 Agrees | 7 Disagrees | Report Abuse »
Uh, "Republican gridlock" is not a valid term.
"In politics, gridlock or deadlock or political stalemate refers to a situation when there is difficulty of passing laws in a legislature because the votes for and against a proposed law are evenly divided, or in which two legislative houses, or the executive branch and the legislature are controlled by different political parties, or otherwise cannot agree."
See? It does take two to do the DC tango.
The participants? Democrats and Republicans.
Democrat slanted viewpoint? Yes, that is a valid term.
5 Agrees | 7 Disagrees | Report Abuse »
"Even a Democrat cannot tell you how they will repay these TRILLIONS Their answer is raise taxes.. but nothing about stopping the increase in debt we see daily."
Did y'all see some libs here go postal about McConnell's pork deal? Why no squeal about Democrat pork?
I say ALL pork is pork, whether it's Dem or Rep. ALL money projects should go under the knife, for trimming, for cutting, or for discarding.
5 Agrees | 7 Disagrees | Report Abuse »
Must have touched a "tolerant" nerve there, huh?
If liberals choose to portray themselves as the more enlightened, the more fair, the more just, the more compassionate, and yes, the more tolerant, it shouldn't bother them a bit to look in the mirror now and then.
I can agree, enough is enough, Veritas.
5 Agrees | 7 Disagrees | Report Abuse »
Lets just take one of bdgi's ludicrous statements and dissect it: "Republicans are for less debt and more business with less EPA interferance." We have a history to verify bdgi's statement... False-Pants on fire- complete distortion. Well, we have had twenty years of Republican leadership in Reagan, Bush, and bush. In each tenure, there was massive deficit spending, huge deregulation, and wild spending. History shows that, figures back it up. Take that premise and shove it. It is a lie.
6 Agrees | 4 Disagrees | Report Abuse »
BDGI, you have never published any facts in your blogs. Just like your last one about Afghanistan and no end in sight. But, you have no idea on the government spending. My blog was correct and it can be verified on any site except Fox News. Republicans are the huge spenders and have hurt the country financially. As to the deficit, it is dropping fast which never has happened under the Republicans. As to the figures you present, remember we are under all the programs that the Republicans set up during Bush's term. The obstructionist Republicans have made sure of that. So, take your out of state opinions and stuff them. Your blogs are full of lies and hatred. You are the person of hate on the blog and it is time for you to blog in your state. We still have Trillion dollar waste in the tax gifts to the rich, medicare D, the wars, taking care of the veterans, and it is from the Republican legacy.
6 Agrees | 3 Disagrees | Report Abuse »
Bdgi, is it "experation or expiration?" The Bush tax GIFT's were extended when the Republicans blackmailed the Administration into extending it by withholding approval of an extension of the unemployment benefits at Christmas time. The scrooge effect of the Republican party. So, in essence, the Republicans forced the extension or a lot of middle class Americans would have been devastated right at Christmas. Does this mean that The Republicans hate the middle Class. On your way of thinking, that would be true.
2 Agrees | 3 Disagrees | Report Abuse »
Don't even begin to talk about the veterans, loser. the Republican party has cut veterans services since back to Reagan. Bush II cut funding to veterans and veteran facilities throughout his administration. The current crew of right wingers has continued to cut veterans benefits by pushing through the sequestration (Boehnor- I got 98% of what I wanted). It is estimated that it will cost in the neighborhood of 3-4 Trillion dollars for veterans rehabilitation over the next twenty or more years and all because the Republicans lied about WMDs so they could get to the oil in Iraq. But, of course, Iraq will pay for the war etc, etc. You know nothing except that again you have pointed out that Republicans must hate veterans.
2 Agrees | 3 Disagrees | Report Abuse »
Oh, and don't even bring up medicare part D. You don't know what you are talking about. That bill immediately gave 2 Billion dollars in profit to the Pharma's. Set up a subsidized medicare supplement program that we pay for every day, and then instead of allowing the government to get competitive bids on pharmaceuticals, it allowed the pharma's to max charge medicare for drugs. Don't you even think about defending that 1.5 trillion dollars boondoggle to the pharmaceutical industry.
2 Agrees | 3 Disagrees | Report Abuse »
So, in summary, bdgi, your posts are total miss information and irrelevant to any intelligent discussions. We are lucky to be getting out of the Iraq/Afghanistan debacle as soon as we are. Bush led us to a disaster that he was warned to stay out of by his own father. There was no exit strategy and because of the surrounding countries, you could not pull out, just like that. Take your out of state ignorance and keep it out of state.
2 Agrees | 3 Disagrees | Report Abuse »
Oh, and one more thing, bdgi, lets see the sites for the payoff thingy. You cannot back up what you say factually, so you make things up. You comments on Pelosi show your complete lack of understanding and also how little you really know.
2 Agrees | 3 Disagrees | Report Abuse »
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- LOA: 65.00m
- Year: 2013
- Exterior designer: A-Sign Studio
- Vessel type: MY
- Guest cabins: 8
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IceFeatured in SuperyachtDesign Q17, Ice is a 65m concept by industrial designer and founder of A-sign Studio, Francesco Struglia. Here the Italian designer explains the thinking behind the project, which was inspired by the aesthetics and scale of icebergs …
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We provide an overview of the design sector and reveal how the market has developed over the past six years.
The ultimate studio guide, this portfolio presents key projects, ideas and the personalities behind leading superyacht design studios.
Our latest issue is packed with interviews, design trends and opinion from those in the know.


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realmagick.com The shrine of knowledge.
A selection of articles related to rejecting.
Original articles from our library related to the Rejecting. See Table of Contents for further available material (downloadable resources) on Rejecting.
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
Rejecting is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Rejecting books and related discussion.
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- Family of teen killed for rejecting prom date sues school
- The family of a teenager who was stabbed to death by a classmate inside her Connecticut high school for rejecting his prom invitation has filed a lawsuit alleging the school didn't adequately respond to signs the boy was capable of violence.
- Tripura youngster sets minor afire for rejecting advances
- A youngster allegedly set a 17-year-old girl on fire for rejecting his advances in Gomati district, Tripura, on Monday evening. Pinki Debnath, who suffered 90% burns in the incident, was admitted to Agartala's GBP Hospital in a critical state.
- LS passes Aadhar Bill rejecting Rajya Sabha recommendations
- New Delhi: Rejecting Rajya Sabha's five amendments and opposition's appeal not to make "haste", the Lok Sabha on Wednesday passed the legislation that aims at better targeting of subsidies through the Aadhaar unique identity number within hours of the ...
- Republicans rejected elite agenda along with Rubio
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text:
The problem I'm working on is for a boundary layer equation for an aerodynamics problem. But I'm having issues working out the partials for it, its been a long while since I've done them and I'm just not getting it to work out. Now for the problem.
I have functions:
where is
I need to find the following partials for my problem:
, , , , , , ,
The second order are the ones I know I'm totally missing, the others I may be getting but it'd be nice to get a sanity check. The ones in terms of and x may cancel out when it goes back into my aerodynamics but I'm not positive of that yet.
Thanks for any help, believe me I've given this problem a solid 14 hours of head bashing yesterday before asking for help.
Ok let me post what I've got thus far:
I'm leaving as it is because it should cancel out when the correct partials are plugged back into the actual aerodynamic problem.
That's what I've got on my own, is the one I'm pretty sure I'm lost on but I would be I'm probably off on others as well.
Thanks for the response thus far and any further help.


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Over the years, the NFL has evolved into a passing league—meaning that quarterbacks need to be at the top of their game in order to win while having a productive wide receiver to throw to.
In the NFL's illustrious history, there has been a tremendous amount of quarterback-to-wide receiver connections that have been memorable. Some that come to mind is Peyton Manning to Marvin Harrison, Steve Young to Jerry Rice and Tom Brady to Randy Moss.
Along with those three stated, who else belongs on this list?
Here are the top 50 QB-WR tandems in NFL history.


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I want to point out before I start that some may think a 28 year old praising a game that came out when I was about 13 years old would be, at least in part, because of nostalgia. I am happy to say that this is not the case whatsoever. As disappointed as I could be that I didn't get the opportunity to play this masterpeice at a young age, I am just as happy that I was able to play it when it was released for the Nintendo DS in 2008.
Having already played many of the games in the Final Fantasy series, I was eager to start looking into some other RPG's. Older ones, if I could get my hands on them. All I had ever heard about Chrono Trigger was that many people had said that it was a great game.
For all of the things that I feel that this game did right, with gameplay innovation, (No random battles, deep tech system, all battles occuring on the main gameplay screen) to the impressive graphics, and the endearing characters, I think that the best part of this game that I will always remember, will be the music.
These are just a few of the game's tracks that really stand out to me:
Battle with Magus: When this music starts, you know you're in for an epic battle. It is up there with 'One Winged Angel' (Final Fantasy VII), "Golbez, Clad in Dark" (Final Fantasy IV), and "Dancing Mad" (Final Fantasy VI) as my favorite boss themes of all-time.
Boss Theme 2: Great music that really makes you feel that this enemy will not be as easy as those in the past. Really gets me eager to fight.
Corridors of Time: This one benefits from being played when you discover the Zeal Kingdom for the first time. An absolutely beautiful track on its own, it is that much more memorable playing at a critical point in the game.
Zeal Palace: The contrast of this piece compared to Corridors of Time is awesome. When you first set foot in the palace, and hear this tune, you get that ominous feeling that something tragic will soon happen.
Undersea Palace: Just a great piece on its own that is made all the more epic by the fact that it still plays even while in the midst of a battle. A great touch.
Schala's Theme: A song that speaks of the tragedy that Schala's character suffers through. The fact that it was used so little in-game makes it all the more memorable. Bonus points for inspiring the background music in a rap song.
Sealed Door: Pure mystery in musical form. If I had a gun to my head, and could only pick one, this would have to be my favorite. Sheer brilliance.
I hope this blog brought back fond memories for all the fans of this wonderful game, and if you've never played it, then stop reading and go get a copy. You will not be disappointed.


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Information Morning Cape Breton
Information Morning Cape Breton | Weekdays 6 a.m. to 8:37 a.m. | CBC Radio One
Join Information Morning's host Steve Sutherland and news editor Hal Higgins starting at 6 a.m. on weekdays.
Cape Breton flood a benefit for Bras d'Or ecosystem, says CBU scientist
Bras d'Or Lake marine life could actually be enhanced by raging floodwaters flowing into it, according to Cape Breton University marine biologist Bruce Hatcher.
SYDNEY FLOOD 'What are the next steps?': Flooded homeowners plead for help from experts
What to do next if you've been affected by the flooding in Cape Breton.video
Damage in the 'millions and millions' of dollars after unprecedented storm
The widespread damage caused by flooding in the Cape Breton Regional Municipality has prompted the mayor to seek disaster assistance, a day after record-breaking rainfall in the area.
Information Morning Cape Breton Clips
Monday October 24, 2016
Audio CBRM Public Works Update
All In A Day's Work Or 14... We check in with Public Works in the CBRM to discuss the work it's already done... and still has to do... in the wake of the Thanksgiving Day storm. Public Works Manager John Phalen updates its post-flood projects.
Monday October 24, 2016
Audio Breakfast Biographies - Dr. Teresa MacNeil
"The Breakfast Biographies" is our series of profile interviews with interesting Cape Breton characters who we think you would like to get to know better. Today, a force to be reckoned with... we introduce you to Dr. Teresa MacNeil.
Friday October 21, 2016
Audio New CBRM Councillors
Meet 3 of the 4 CBRM rookie, soon-to-be-sworn in Councillors. Earlene MacMullin's win in District 2 is subject to a judicial recount. Kendra Coombes represents District 11, Steve Gillespie in District 4, and Amanda McDougall for District 8.
Friday October 21, 2016
Audio King's Road Reserve Commemoration
Remembering a Moving Event... The Membertou community is preparing to mark the anniversary of its forced relocation from King's Road with a special ceremony. Dan Christmas, senior advisor to the Membertou Band Council, outlines the history of the event.
Friday October 21, 2016
Audio Edventure Cape Breton
Moving education outdoors... The Edventure Cape Breton group invites you to a forum at the McConnell Library in Sydney to discuss ways to offer kids opportunities to learn outside the classroom. Megan MacLeod is a founding member of Edventure Cape Breton.
Thursday October 20, 2016
Audio Craft Brewing Industry in NS
Jeremy White, the owner of Cape Breton's Big Spruce Brewing, says the province is unfair to microbreweries like his. Randy Delorey is Nova Scotia's Minister of Finance, the department responsible for the NSLC, responds.
Thursday October 20, 2016
Audio Flood - NS Department of Environment
Inspectors from the Environment Department are in the CBRM checking out the flooded areas. We ask Adrian Fuller, Executive Director of Compliance for the Nova Scotia Department of Environment, what they're doing, and what they're finding.
Thursday October 20, 2016
Audio Minister of Education and NSTU President
Some say it's an olive branch, others say she's poking a stick. But the Minister of Education's offer to teachers to create "the partnership on systemic working conditions" has been accepted. Karen Casey and Liette Doucet talk about that.
Severe weather warnings or watches in effect for:
Mostly Cloudy
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Annapolis Royal
Light Rainshower
Light Rainshower
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- Donald Trump and new housing rules delay Canada's growth takeoff: Don Pittis
- Polls favourable to Donald Trump may be overestimating his support, state polls suggest
- Canada-EU trade summit Thursday will likely be postponed: top official
- Functionally bilingual requirement for Supreme Court justices here to stay, says Wilson-Raybould
- Liberals promise to bring Yazidi refugees to Canada within 4 months
- Canada-EU trade deal on hold as Belgium fails to reach agreement
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- Canada-EU trade summit Thursday will likely be postponed: top official
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Dinner, auction to benefit Cafe at the Plaza server
If you've eaten at Cafe at the Plaza, you've probably been called "honey" by server Edna Smith at one time or another.
Smith has been away from work, fighting cancer for several months. If you'd like to show some sweetness in return, organizers are holding a benefit dinner and silent auction at the downtown Art Deco hotel on Dec. 13 to help her with her medical bills. »Read Full Blog Post
Sally Struthers brings experience, humor to 'Hello, Dolly!'
If the cheerful and idealistic Gloria Stivic had stayed with us during the decades since "All in the Family," what would the intervening years have made of her?
Having won two Emmys playing Meathead's wife, Sally Struthers is back with the answer: The increasingly confident Gloria would have become matchmaker Dolly Levi, rendered sharper and more pragmatic by life's knocks but still every bit as warm and loving, and even more of a stitch. »Read Full Article
Milwaukee Symphony makes most of cathedral setting in concert
The phrase "working the room" clearly means different things to people.
The Milwaukee Symphony Orchestra and associate music director Francesco Lecce-Chong moved their proverbial tent to the Cathedral of St. John on Friday evening and worked the room beautifully with a program of Pärt, Bach and Bruckner that was perfectly tailored to the acoustics and ambience of the space. »Read Full Article
Skaggs, Hornsby pair piano with frenetic fiddlin' around
From the carefully placed microphones to the stringed instruments in the hands of Ricky Skaggs and the six members of Kentucky Thunder, the stage of the Northern Lights Theater at Potawatomi Bingo Casino was clearly set Friday for an evening of bluegrass music.
Had that been the bill, it would have been a fine show of prodigious talent playing the music Skaggs has been mastering since his youth. But there in the middle of the stage was an unusual addition to bluegrass tradition: a grand piano and its own experimental master, Bruce Hornsby. »Read Full Article


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2016 IB DIPLOMA SUCCESS100% success: our students go on to study at the university of their choice
WELCOME TO RISOffering the best international education in Rome
ENRICHING STUDENT LEARNINGOur High School students regularly attend the Model United Nations Conference in New York.
Our mission is to provide a nurturing environment, in which children of all nationalities and faiths can explore and respect their own and each other's cultural and religious heritage. Read more...
With a student intake of 40 different nationalities, RIS is the ideal context for a rewarding educational experience. We encourage parents to visit our school to see the campus and to meet students and staff. Find out more.


text:
Here are a few tips:
Reference the parking map.
Consider buying advance parking.
Get the SunFest App powered by Ford
for parking locations & details.
Parking does not include festival admission. The City of West Palm Beach runs the City lots. No in and out privileges. PARKING MUST BE PURCHASED BY 10 PM OF THE PRECEDING DAY (ex. Friday Parking must be purchased by 10 PM Thursday).


text:
Welcome to The Almonte District Improvement Club
105 Wisteria Way, Mill Valley
Quarterly Newsletter
1st Quarter
Annual Meeting
The board of the Almonte District Improvement Club would like to invite you to our annual meeting and dinner on March 6th between 4-7 PM. This meeting is where you can learn what is happening in the district, how we operate, our financial picture, and what the club does for you. This year we will be trying something a little different and hope to have your input. Cocktail hour will be between 4-5 PM, followed by dinner, pizza and burritos plus dessert, a brief 10-15minute annual meeting between 5-6 PM, and free bingo with prizes from 6-7 PM.
Little Libraries
We are continuing to work on our Little Libraries project which is going well. Several residents have donated books and taken some to read. This is a great project which has seen success in other neighborhoods in Mill Valley. Look for the red library box in front of the clubhouse and give and take a book or two.
This year we are hoping to work on marking the trails in Almonte which would allow residents to get down the hill in the event of a disaster.
The Club House
Remember the board offers the clubhouse to residents at no cost on the third Saturday of each month from 3-6 PM. The clubhouse is a great spot for parties, meetings, etc. so come and check it out.
Future Events
We would like to start a regular Pizza & Bingo night at the club. This will be ongoing if the neighborhood enjoys the idea of getting together regularly for fun and eats.


text:
Most Cited Drug Discovery Today: Disease Models Articles
The most cited articles published since 2011, extracted from Scopus.
A neurobiological model of insomniaDaniel J. Buysse | Anne Germain | Martica Hall | Timothy H. Monk | Eric A. Nofzinger
Volume 8, Issue 4, December 2011, Pages 129-137
Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an insomnia model based on basic and clinical neuroscience findings, and hypothesize that insomnia results from persistent activity in wake-promoting neural structures during non-rapid eye movement (NREM) sleep. The simultaneous occurrence of activity in sleeping and waking neural activity helps to explain clinical phenomenology and treatment effects in insomnia.
The symptom cluster of sleep, fatigue and depressive symptoms in breast cancer patients: Severity of the problem and treatment optionsLavinia Fiorentino | Michelle Rissling | Lianqi Liu | Sonia Ancoli-Israel
Volume 8, Issue 4, December 2011, Pages 167-173
Breast cancer is the most commonly diagnosed cancer in women. Insomnia is a significant problem in breast cancer patients, affecting between 20% and 70%ofnewly diagnosed or recently treated breast cancer patients. Pain, fatigue, anxiety and depression are also common conditions in breast cancer and often co-occur with insomnia in symptom clusters, exacerbating one another anddecreasingqualityoflife(QOL).Therehave been no clinical trials of drugs for sleep in cancer. Cognitive behavioral psychotherapies on the contrary have shownsomeofthemostpositiveresultsinalleviatingthe distressing symptoms that often accompany the breast cancer experience, but even these studies have not targeted the symptom cluster. Pharmacological as well as non-pharmacological treatments need to be explored. It might be that a combined pharmacological and behavioral treatment is most efficacious. In short, substantially more research is needed to fully understand and treat the symptom cluster of insomnia, fatigue, pain, depression and anxiety in breast cancer.
Fish in a dish: Drug discovery for hearing habilitationRobert Esterberg | Allison B. Coffin | Henry Ou | Julian A. Simon | David W. Raible | Edwin W. Rubel
Volume 10, Issue 1, March 2013, Page
The majority of hearing loss is caused by the permanent loss of inner ear hair cells. The identification of drugs that modulate the susceptibility to hair cell loss or spur their regeneration is often hampered by the difficulties of assaying for such complex phenomena in mammalian models. The zebrafish has emerged as a powerful animal model for chemical screening in many contexts. Several characteristics of the zebrafish, such as its small size and external location of sensory hair cells, uniquely position it as an ideal model organism for the study of hair cell toxicity, protection, and regeneration. We have used this model to screen for drugs that affect each of these aspects of hair cell biology and have identified compounds that affect each of these processes. The identification of such drugs and drug-like compounds holds promise in the future ability to stem hearing loss in the human population. © 2012 Elsevier Ltd. All rights reserved.
Poly(ADP-ribose) polymerase (PARP) and PARP inhibitorsNicola J. Curtin
Volume 9, Issue 2, June 2012, Page
PARP-1 protects cells from endogenous and therapeutically inflicted DNA damage. PARP inhibitors have been under development since 1980 and first entered clinical trial in 2003. They are an exciting new class of drugs that have the potential to increase the efficacy of anticancer DNA damaging agents and to selectively target cells that have defects in other DNA repair pathways. There are now nine PARP inhibitors undergoing clinical evaluation. © 2011 Elsevier Ltd. All rights reserved.
Mast cell proteases and inflammationHongyan Dai | Ronald J. Korthuis
Volume 8, Issue 1, March 2011, Pages 47-55
Mast cells are not only best known for their role in allergic reactions but are also now recognized for their important contributions to several disparate inflammatory conditions through the release of inflammatory mediators, serglycin and other proteoglycans, and proteases. Because these tissue resident inflammatory cells express proteases in such great abundance and their enzymatic activity results in cleavage of a multitude of proteins and peptides, which in turn modify tissue function, their substrate specificity, tissue distribution and mode of action have become the subjects of great interest. Although mast cell protease-dependent proteolysis is crucial to host defense against invading pathogens, regulation of these hydrolytic enzymes is essential to limiting self-induced damage as well. Indeed, dysregulated release of mast cell proteases is now recognized to contribute to the pathogenesis of several inflammatory conditions including asthma, abdominal aortic aneurysm formation, vessel damage in atherosclerosis and hypertension, arthritis and ischemia/reperfusion injury. Understanding how mast cell proteases contribute to inflammation will thus help unravel molecular mechanisms that underlie such immunologic disorders and will help identify new therapeutic targets for drug development. © 2011 Elsevier Ltd. All rights reserved.
Matrix metalloproteinases and small artery remodelingLuis A. Martinez-Lemus | Edgar Luis Galiñanes
Volume 8, Issue 1, March 2011, Pages 21-28
Inward eutrophic remodeling is a common structural change found in small resistance arteries that has been associated with an increased risk for life threatening cardiovascular events, the number one cause of death in industrialized societies. Because inward eutrophic remodeling is the most prevalent small artery structural change found in hypertension, hypertensive animals are the most common in vivo models used to study this particular remodeling process. In vitro, the isolated artery, pressure myograph has also been used as a model to study the mechanisms responsible for the development of small artery remodeling. Compelling recent evidence indicates that the matrix metalloproteinases (MMPs), a family of endopeptidases whose primary function is the cleavage and degradation of extracellular matrix components, are involved in vasoconstriction and the pathogenesis of hypertension. In this review, we provide an overview of the known and potential roles that MMPs have on vascular remodeling, paying particular attention to their role on the inward eutrophic remodeling process of small resistance arteries that occurs in hypertension. © 2011 Elsevier Ltd. All rights reserved.
ADMETox in zebrafishH. Diekmann | A. Hill
Volume 10, Issue 1, March 2013, Page
To enable the widespread use of zebrafish larvae in drug discovery, it is required to define drug concentration at the target site and to assess metabolites at a resolution necessary for in vivo pharmacology screening. These questions are now being investigated using mass spectroscopy and contribute to our understanding of how the outcome of zebrafish toxicity, safety and efficacy studies can translate to rodent and human data. © 2012 Elsevier Ltd. All rights reserved.
Protease activity and the role of the endothelial glycocalyx in inflammationHerbert H. Lipowsky
Volume 8, Issue 1, March 2011, Pages 57-62
A new paradigm for governance of leukocyte-endothelium (WBC-EC) adhesion during the inflammatory process is presented in which shedding of the endothelial glycocalyx exposes adhesion molecules on the EC surface, which promotes WBC-EC adhesion. It is postulated that the effector of this shedding is the activation of extracellular proteases, one of which may be a member of the matrix metalloproteinase (MMP) family of zinc dependent endopeptidases. This model for the role of the glycocalyx as a barrier to WBC-EC adhesion includes the additional participation of normally active extracellular proteolytic enzymes, that is, sheddases, which may cleave proteoglycans or activate lyases that cleave GAG chains in the glycocalyx. In support of this hypothesis, studies are examined which have established the concurrent activation of MMP proenzymes on the EC surface, shedding of the glycocalyx, and enhanced WBC-EC adhesion. © 2011 Elsevier Ltd. All rights reserved.
MicroRNAs are potential therapeutic targets in fibrosing kidney disease: Lessons from animal modelsJeremy S. Duffield | Monica Grafals | Didier Portilla
Volume 10, Issue 3, January 2013, Page
Chronic disease of the kidneys has reached epidemic proportions in industrialized nations. New therapies are urgently sought. Using a combination of animal models of kidney disease and human biopsy samples, a pattern of dysregulated microRNA expression has emerged which is common to chronic diseases. Several of these dysregulated microRNAs have recently been shown to have functional consequences for the disease process and therefore may be potential therapeutic targets. We highlight microRNA-21, the most comprehensively studied microRNA in the kidney so far. MicroRNA-21 is expressed widely in healthy kidney but studies from knockout mice indicate it is largely inert. Although microRNA-21 is upregulated in many cell compartments including leukocytes, epithelial cells and myofibroblasts, the inert microRNA-21 also appears to become activated, by unclear mechanisms. Mice lacking microRNA-21 are protected from kidney injury and fibrosis in several distinct models of kidney disease, and systemically administered oligonucleotides that specifically bind to the active site in microRNA-21, inhibiting its function, recapitulate the genetic deletion of microRNA-21, suggesting that inhibitory oligonucleotides may have therapeutic potential. Recent studies of microRNA-21 targets in kidney indicate that it normally functions to silence metabolic pathways including fatty acid metabolism and pathways that prevent reactive oxygen species generation in peroxisomes and mitochondria in epithelial cells and myofibroblasts. Targeting specific pathogenic microRNAs is feasible in vivo and may be a new therapeutic strategy in disease of the kidney. © 2012 Elsevier Ltd. All rights reserved.
Cardiovascular regulation in obstructive sleep apneaMichael G. Ziegler | Milos Milic | Hamzeh Elayan
Volume 8, Issue 4, December 2011, Pages 155-160
The majority of patients with obstructive sleep apnea (OSA) suffer from hypertension as a complication of both the metabolic syndrome and OSA. In animal studies, intermittent hypoxia that simulates changes seen in OSA leads to chemoreceptor and chromaffin cell stimulation of sympathetic nerve activity, endothelial damage and impaired blood pressure modulation. Human studies reveal activation of sympathetic nerves, endothelial damage and exaggerated pressor responses to sympathetic neurotransmitters and endothelin. Although treatment of the OSA normalizes sympathetic nerve responses, it only lowers blood pressure modestly. Agents that block the consequences of sympathetic over activity, such as β1 blockers and angiotensin antagonists have effectively lowered blood pressure. Diuretics have been less successful. Treatment of hypertensive patients with OSA usually requires consideration of both increased sympathetic nerve activity and the metabolic syndrome.
New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseasesJoaquín Pérez-Schindler | Christoph Handschin
Volume 10, Issue 2, June 2013, Page
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases. The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a key molecule in the regulation of oxidative metabolism in different tissues, including skeletal muscle. In this tissue, physical exercise is one of the most dominant physiological stimuli to induce PGC-1α. In addition, exercise training efficiently prevents the development of metabolic diseases. Hence, better knowledge about the regulation of PGC-1α by exercise would significantly help to design effective treatments for these diseases. © 2013 Elsevier Ltd. All rights reserved.
Genetically modified mouse models of cancer invasion and metastasisPaulina Rampetsreiter | Emilio Casanova | Robert Eferl
Volume 8, Issues 2-3, September 2011, Pages 67-74
Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis. © 2011 Elsevier Ltd. All rights reserved.
Organotypic spheroid cultures to study tumor-stroma interaction during cancer developmentHelmut Dolznig | Angelika Walzl | Nina Kramer | Margit Rosner | Pilar Garin-Chesa | Markus Hengstschläger
Volume 8, Issues 2-3, September 2011, Pages 113-119
Metastasis, which is linked to the invasive properties acquired by the primary tumor during cancer progression, is the major life-threatening event in cancer patients. There is increasing evidence that the tumor stromaisinvolvedinthe infiltrative growthof malignant cells. Many models have been developedtostudytumor/stroma interaction and 3 Dmodel systems represent the most promising approaches, becausethey closely mimic the situation in vivo. The main goal of these models is to better understand tumorigenesis and to discover novel therapeutic avenues to treat cancer. © 2011 Elsevier Ltd. All rights reserved.
Polymicrobial sepsis models: CLP versus CASPGernot Schabbauer
Volume 9, Issue 1, March 2012, Page
Sepsis is a disease syndrome covering many different aspects of the host immune system. Our understanding of sepsis is still incomplete. Several animal models of sepsis have been developed and much of our current knowledge on the molecular basis of the disease has originated from these models. Two of the most reliable and clinically relevant rodent models to mimic human sepsis in the animal model are cecal ligation and puncture (CLP) and colon ascendens stent peritonitis (CASP). © 2011 Elsevier Ltd. All rights reserved.
Angiogenesis and proteinases: Influence on vascular morphogenesis, stabilization and regressionGeorge E. Davis
Volume 8, Issue 1, March 2011, Pages 13-20
Proteinases play a key role during angiogenesis and have been implicated in vascular morphogenesis, stabilization and regression. Major advances have identified specific proteinases and their inhibitors that separately control these processes. Relevant proteinases include cell surface or soluble metalloproteinases, serine proteinases and cathepsins that affect these events and a crucial issue concerns how these proteinases are balanced by their inhibitors to affect tissue vascularization. Importantly, heterotypic communication of endothelial cells with vessel supporting cells such as pericytes controls proteinase and inhibitor expression to regulate these processes. © 2011 Elsevier Ltd. All rights reserved.
Tumor-stroma: In vivo assays and intravital imaging to study cell migration and metastasisZhen Ni Zhou | Pamela J. Boimel | Jeffrey E. Segall
Volume 8, Issues 2-3, September 2011, Pages 95-102
The development of metastatic disease is often correlated with poor patient outcome in a variety of different cancers. The metastatic cascade is a complex, multistep process that involves the growth of the primary tumor and angiogenesis, invasion into the local environment, intravasation into the vasculature, tumor cell survival in the circulation, extravasation from the vasculature and sustained growth at secondary organ sites to form metastases. Although in vitro assays of single cell types can provide information regarding cell autonomous mechanisms contributing to metastasis, the in vivo microenvironment entails a network of interactions between cells which is also important. Insight into the mechanisms underlying tumor cell migration, invasion and metastasis in vivo has been aided by development of multiphoton microscopy and in vivo assays, which we will review here. © 2011 Elsevier Ltd. All rights reserved.
Modelling distinct modes of Tumour invasion and metastasisNeil O. Carragher | Margaret C. Frame
Volume 8, Issues 2-3, September 2011, Pages 103-112
Tumour metastasis, the process by which tumour cells spread throughout the body, is the principle cause of mortality for cancer patients. The complexity and redundancy in mechanisms of metastasis have hampered the development of effective anti-metastatic therapies. Recent advances in imaging and proteomic technologies are enhancing our ability to model and understand the metastasis process. In this article we describe a variety of modern in vitro and in vivo tumour invasion models and discuss how each can be applied to place specific target classes, into appropriate disease context, thereby facilitating more insightful therapeutic targeting. © 2011 Elsevier Ltd. All rights reserved.
Engineered human pluripotent stem cell-derived cardiac cells and tissues for electrophysiological studiesDeborah K. Lieu | Irene C. Turnbull | Kevin D. Costa | Ronald A. Li
Volume 9, Issue 4, December 2012, Page
Human cardiomyocytes (CMs) do not proliferate in culture and are difficult to obtain for practical reasons. As such, our understanding of the mechanisms that underlie the physiological and pathophysiological development of the human heart is mostly extrapolated from studies of the mouse and other animal models or heterologus expression of defective gene product(s) in non-human cells. Although these studies provided numerous important insights, much of the exact behavior in human cells remains unexplored given that significant species differences exist. With the derivation of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSCs) from patients with underlying heart disease, a source of human CMs for disease modeling, cardiotoxicity screening and drug discovery is now available. In this review, we focus our discussion on the use of hESC/iPSC-derived cardiac cells and tissues for studying various heart rhythm disorders and the associated pro-arrhythmogenic properties in relation to advancements in electrophysiology and tissue engineering. © 2012 Elsevier Ltd. All rights reserved.
Epigenetic modulations of induced pluripotent stem cells: Novel therapies and disease modelsChengyang Huang | Joseph C. Wu
Volume 9, Issue 4, December 2012, Page
Recent breakthroughs in induced pluripotent stem cell (iPSC) technology hold promise for novel cell-based therapies as well as for effective drug development. The therapeutic potential of iPSCs makes it important to understand the reprogramming mechanisms and iPSC differentiation process. Epigenetic states that mediate exogenous stimulations on cell-intrinsic transcriptional features play a key role in iPSCs. This review focuses on epigenetic mechanisms that control iPSC pluripotency and differentiation. We discuss the potential application of epigenetic modulations in development of iPSC-based therapies and disease models. © 2012 Elsevier Ltd. All rights reserved.
The DNA damage response to monofunctional anticancer DNA bindersDaniele G. Soares | Annette K. Larsen | Alexandre E. Escargueil
Volume 9, Issue 2, June 2012, Page
Combinations of different experimental modalities including yeast, mammalian cells, xenografts and in silico models have proved useful in elucidating the mechanism of action of novel anticancer agents including covalent DNA binders like the ecteinascidins (trabectedin/ yondelis, zalypsis and PM01183) and to characterize their influence on tumor cell biology. The experimental models can also lead to identification of predictive markers and provide a rational for development of more efficient/less toxic drug combinations, thereby facilitating clinical development. © 2011 Elsevier Ltd. All rights reserved.
The social honey bee in biomedical research: realities and expectationsRyszard Maleszka
Volume , Issue , August 2014, Page
The social honey bee, Apis mellifera, is an organism of great value for behavioural, ecological and evolutionary studies. It is also an important agricultural insect and a source of allergies. In recent years its usefulness for research communities has been significantly expanded as a result of progress in genomics and epigenomics. While the bee is not to be misjudged as a model for a specific human disease, it complements other invertebrate models in areas of DNA methylation, metaboloepigenetics and is a source of medically and epigenetically active compounds. This article outlines the anticipated benefits flowing from the epigenome-inspired projects in honey bees and draws attention to the most promising avenues that are likely to strengthen the value of this organism in biomedical research. © 2014 Elsevier Ltd. All rights reserved.
Imaging vertebrate digestive function and lipid metabolism in vivoJessica P. Otis | Steven A. Farber
Volume 10, Issue 1, March 2013, Page
Challenges in imaging lipid-processing events in live, intact vertebrate models have historically led to reliance on cultured cell studies, thus hampering our understanding of lipid metabolism and gastrointestinal physiology. Fluorescently-labeled molecules, such as BODIPY-labeled lipids, can reveal lipid-processing events in live zebrafish (Danio rerio) and has expanded our understanding of digestive physiology. This review will cover recent advances from the past two to three years in the use of fluorescence-based imaging techniques in live zebrafish to characterize gastrointestinal physiology in health and disease and to conduct small molecule screens to discover therapeutic compounds. © 2012 Elsevier Ltd. All rights reserved.
Regulation of matrix metalloproteinase expressionJennifer L. Gorman | Eric Ispanovic | Tara L. Haas
Volume 8, Issue 1, March 2011, Pages 5-11
The matrix metalloproteinases are a family of matrix degrading enzymes that are important regulators of extracellular matrix remodelling and cellular function. This article presents a review of the mechanisms through which MMPs are regulated including transcriptional, post-transcriptional and post-translational events. Regulation of MMPs within the cardiovascular system and their contribution to physiological and pathological events will be discussed. © 2011 Published by Elsevier Ltd. All rights reserved.
High throughput in vivo phenotyping: The zebrafish as tool for drug discovery for hematopoietic stem cells and cancerVera Binder | Leonard I. Zon
Volume 10, Issue 1, March 2013, Page
The zebrafish is an important model for the study of development and disease. Its miniature size, large numbers and optical clarity make it advantageous for high-throughput in vivo phenotyping. In this review we will highlight how the zebrafish contributes to drug discovery by in vivo chemical screening and as a disease model. © 2012 Elsevier Ltd. All rights reserved.
Micromanaging microRNAs: Using murine models to study microRNAs in lung fibrosisChristian L. Lino Cardenas | Naftali Kaminski | Daniel J. Kass
Volume 10, Issue 3, January 2013, Page
MicroRNAs are implicated in many biological and pathological processes and are emerging as key actors in lung health and disease. Specific patterns of dysregulated microRNAs have been found in idiopathic pulmonary fibrosis (IPF), an untreatable interstitial lung disease of unknown etiology. IPF is characterized by dramatic and extensive phenotypic changes in the lung that include alveolar cell hyperplasia, fibroblast proliferation and formation of myofibroblast foci, deposition of extracellular matrix, and changes in lung transcriptional programming. Here, we discuss the latest insights about the role of microRNAs in lung fibrosis with a focus on the contribution of animal models of disease to the derivation of these insights. © 2012 Elsevier Ltd. All rights reserved.


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Este˜ ´ levitra stories ´ tica Clınica e Cirurgica. Tratamento da celulite pela subcisao.
275–365). Bamford, & J. Bogousslavsky (Eds.), Subcortical stroke (3nd ed., pp. Norrving, J. New York.
Journal of levitra stories Comparative Neurology, 180(3), 575–620. Catecholamine innervation of the basal forebrain. Topography of the dopamine projection to the basal forebrain and neostriatum. Farde, L., Halldin, C., Stone-Elander, S., & Sedvall, G., (1988).
PET analysis of human dopamine receptor subtypes using 9C-SCH 23490 and 12C-raclopride. (1976).
DNQX in the nucleus accumbens inhibits levitra stories cocaine-induced conditioned place preference. (1995). (1993). W. Brain Research 757, 76–82.
Kalivas, P. J., and Wallace, L. J.
And does not allow estimation of prognosis, the true nature and extent levitra stories of the liver damage is not proportional to the elevation in serum enzyme activity. Although the serum AST may be elevated modestly when ALT is not in acute alcohol-induced liver injury, other enzymes are no better indicators. It is very costly to screen thousands of people repeatedly in the hope of catching one who may show an abnormality.
The serum ALT is a fairly sensitive test for liver injury, but does not measure liver function at all. Regulatory Perspectives 833 If the acute liver injury is rapid in onset, as it may be, it could well occur during the interval between tests.


text: Which Fall TV Show Will Rock Your World? Our Spoiler-Free Impressions!Katharine Trendacosta7/09/15 10:00am31115EditPromoteDismissUndismissHideGo to permalinkLast night at Comic-Con, we saw four of this fall's most hotly awaited new TV shows. Which one will be your new obsession, and which will be the next epic disaster? Out of four new shows, one was pretty much as good as we expected, two were blah... and one was a nice surprise. Here's our spoiler-free rundown.


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When you want to share your Excel table with your team on an ongoing basis, working with SharePoint lists can be easier for viewing and editing the data.
For more information on tables, see Create and delete an Excel table in a worksheet.
Important: Before exporting your table, make sure you have the necessary permissions to create a list on the SharePoint site (contact your server administrator if you're unsure about your permissions), and the site address where you want to publish the table.
Using a SharePoint list to share table data
When you export table data to a SharePoint list, you can:
Share table data with other users who use the SharePoint site On the SharePoint site, other users can continue to update the list by opening the list and changing the data.
Create a one-way connection to the data in the SharePoint list With a one-way connection to the data in the SharePoint list, changes that are made to the data in the SharePoint list can be incorporated in Excel. When you refresh the table data in Excel, the latest data from the SharePoint site overwrites the table data on the worksheet, including any changes that you made to the table data. In Office Excel 2007, you can no longer update a SharePoint list with changes that you make to the table data in Excel after that data has been exported.
If you don't want to keep the table data in the Excel worksheet updated with changes that are made to the SharePoint list, you can export the data without a connection to the SharePoint list.
For information about creating a one-way connection, see Export a table to a SharePoint list.
Supported data types
Some Excel data types cannot be exported to a list on the SharePoint site. When unsupported data types are exported, these data types are converted to data types that are compatible with SharePoint lists. For example, formulas that you create in Excel are converted to values in a SharePoint list. After the data is converted, you can create formulas for the columns on the SharePoint site.
When you export an Excel table to a SharePoint site, each column in a SharePoint list is assigned one of the following data types:
Text (single line)
Text (multiple lines)
Hyperlink (URL)
If a column has cells with different data types, Excel applies a data type that can be used for all of the cells in the column. For example, if a column contains numbers and text, the data type in the SharePoint list will be text.
Export a table to a SharePoint list
Click inside the table you want to export and click Design > Export > Export Table to SharePoint List.
Note: You'll see the Design tab only after you click inside the table.
Tip: Keyboard shortcut: Press and hold the Alt key + J, T, X, E (one key at a time).
In the Address box, type the address, or URL of the SharePoint site.
Important: Type everything that's in your Web address before the "/default.aspx". For example, if the address is, http://contoso/default.aspx type http://contoso.
If you'd like to be able to view the data updates to the SharePoint list and also update your table in Excel, check the Create a read-only connection to the new SharePoint list box.
Note: When you create a read-only connection, two columns are added to the table so that the folders that contain the SharePoint list can be included. An Item Type column indicates whether a row represents a SharePoint list item or a folder. A Path column displays the folder path for a list item (for example, mylist/folder). When you filter the table data, you can filter within the specific folders that are listed in these columns. You can also sort the Path column to group all rows in the same folder together.
In the Name box, type a name that'll help others find your list.
Note: The Next and Finish options become available only after you add a Name.
Optionally, you can add information in the Description box.
Click Next.
Review the information for the Columns and Data Types before you click Finish, and if you need to edit anything, click Cancel.
Click OK to publish your table.
When you see a message indicating that your table is published with a link, you can either view your list right away or view it later by clicking Design >Open in Browser from your workbook.
Update a table from a SharePoint list
You can periodically update your Excel worksheet with changes from the list.
Important: When you refresh the data in your worksheet, you'll be overwriting any changes you might have made to the worksheet after your last export.
Click anywhere in the table that you want to update.
Click Design >Refresh.
Note: Though you can't update any changes from your Excel worksheet to an existing SharePoint list, you can export the changed table as a new list with a different name.
Unlink a table from a SharePoint list
If you no longer want a connection between the table data on the worksheet and the SharePoint list, unlink the table by clicking anywhere in the table, and then clicking Design > Unlink.


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I have a vauxhall nova 1.4SR, its a 1992 (k reg) with just over 100,000 on the clock, but im sure it is relatively unabused as i have had the engine apart and there is no wobble in the pistons, scoring in the bores or anything like that.
I've recently installed a piper blueprint camshaft, and since installation and carb rejetting (of a weber 32/34 DMTL) I've noticed a few problems. For the first ten minutes of running the engine, i get a clicking/tapping noise that sounds like its coming from the cylinder head - im guessing its one of my hydralic adjusters playing up and causing the cam to not be in contact with one of the rockers for the whole of its duration, causing the clicking as it contacts.
Now, i also have another problem - since this has started happening, my oil light has started flashing on and off. At first, it was only when going round right hand corners - the light would come on under heavy cornering and stay on for a couple of seconds after cornering, but as time has gone on - the light now comes on whenever there is any lateral force, eg - if i accelerate hard, brake hard or corner hard in either direction the light will come on.
Could this be a contributing factor to the hydralic valve adjuster playing up? or vice versa?


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Suffice it to say, the season premiere of Grey's Anatomy, "Dream a Little Dream of Me," lived up to the hype - no small feat, especially with the fans on this site!
What was your favorite part?
Steve Marsi is the Managing Editor of TV Fanatic. Follow him on Google+ or email him here.


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Chlorella is a microscopic freshwater plant that is often referred to as one of nature´s green superfoods. On a weight for weight basis it is one of the most nutritionally dense foods to be found in nature containing key vitamins, macro-minerals, trace minerals, anti-oxidants, essential fatty acids, proteins, nucleic acids and much more, in a form that is highly bio-available and which is therefore a perfect inclusion to a varied and balanced diet and healthy lifestyle. Chlorella is excellent for cleansing and detoxifying the body and an exceptional choice for maintaining general wellbeing and healthy vibrancy.
Suggested Use
Consumption can vary with activity levels, state of health & age. Start-up: 2 tablets per day for first week or two. Caution: Chlorella can initially result in mild bowel movement changes in some persons, introduce it slowly and only increase the amount after these changes disappear. Maintenance: 6 tablets per day. Optimum: 6 tablets three times daily or 18 tablets total per day. Best taken at or after meals with plenty of fluid (preferably pure water to assist the removal of toxins). You can take Chlorella with every meal or once a day. Perfect as a broad spectrum green superfood when mixed with Synergy Spirulina.
Facts About Chlorella
- One of nature's perfect whole food supplements containing complete protein (58%), all the B group vitamins (incl. B12), vitamins C and E as well as most major and many rare trace minerals. It is the most common supplement taken by the longest living race on earth, the Japanese.
- Packed with readily bio-available chlorophyll (the highest of any known plant) which greatly assists with cellular metabolism and general detoxification.
- Contains over 20% Chlorella Growth Factor (CGF) which has been shown to support normal cell growth and the immune system.
- A perfect source of nucleic acids (found in RNA and DNA) which assist in cellular renewal, growth and repair.
- Chlorella is an alkaline food which not only counters the over-acidity of many processed foods, but also helps raise our bodily pH levels towards the alkaline side of the scale, thereby greatly assisting metabolic function.
- Abundant phytonutrients and anti-oxidants that can help protect against free radicals and a large number of environmental and dietary pollutants.
- Excellent source of bio-available, blood building iron.
- Chlorella is one of the most scientifically researched foods in history.
100% pure, premium quality Chlorella. Grown outdoors and gently processed by cracking the cell walls for superior digestibility and absorption. No filler or additives used in this product. To preserve the nutrient and enzyme content, each bottle is nitrogen flushed to eliminate oxygen.
Do not exceed the recommended daily intake. Food Supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2016.
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Finally, I got it working, and the PC is outstanding. It's undoubtedly the hardest merchandise Ive ever purchased and put together. Maiberg notes that while the PC is definitely the best area to play games, he doesnt believe most people would trouble, just because of how difficult it's; you. After giving the matter some thought, I consider it is pointing. But past the physical setup of hardware, theres so much more bullshit we used to need to cope with that doesnt exist anymore. Some motherboards had concealed problems between various PCI slots that kept them from used at the exact same time. RAM incompatibility was common, you'd to install AGP drivers for adequate graphics performance, and even installing Windows needed manual intervention to load third party storage drivers much of the time.
These problems werent restricted only to Taiwanese chipsets, either. Intels i820 was such a catastrophe the business had to recall it. The i810 lacked an AGP slot, and its incorporated images provided a normal 2D picture that made even a high end computer screen looking like a thin film of grease was smeared across the display. The i815 followup added an AGP interface but couldnt address more than 512MB of RAM. Enthusiasts regularly purchased 440BX boards because these could manage 133MHz buses through an everyday setting, though this meant you needed an AGP card that could manage a 35% overclock. Athlon and Athlon XP centers of the day were simple to chip. Some of the problems that Maiberg raises could be more readily conveyed. The very first time you lever down a ZIF socket, it may seem like youre doing things wrong, particularly since that pub doesnt go down without some force used.
Others, like the dizzying array of accessible hardware, are more difficult to address. Motherboard and graphic producers each break up their merchandise families into addressable sections, subsequently sell boards based on the value added features they package in at any given price point. This necessarily results in customer confusion. Add in outlets for previous-generation components and unexpectedly youre drowning in hardware. Now multiply that times electricity supplies, graphics cards, CPUs, cases, RAM, and CPU coolers. Maiberg isnt incorrect when he says that getting a handle on all this is a huge elevator. Among the reasons why PC-construct guides in many cases are composed as general discussions instead to extreme specificity is because theres no means for the writer to understand which of possibly millions of combinations of hardware youll be trying to assemble. One could even claim this state of affairs results in fewer folks becoming involved with best gaming PC, which results in lower numbers of earnings than would be the situation if all the interested firms consented to establish fewer products and hewed more closely to common standards.
Its true that Apple offers a streamlined, attractive web site and a considerably easier interface for merchandise variety. Ive written previously about how terrible notebook shopping is and how badly most PC OEMs compare against Apple. But and this is crucial when you purchase a system from Apple as opposed to building one yourself, youre paying for the attempt Apple get into building that system. (Well blow off the fact that Apple blows off gaming and GPU operation and cant be bothered to use a variant of OpenGL thats less than six years old.) Boutique contractors could do a considerably better job of directing and helping would be PC buyers decide hardware, but almost all of them offer pre-assembled boxes with a normal part with the choice to update one specific thing the GPU, as an example. In addition they have phone numbers, chat services, and email addresses and businesses that dont answer to customer questions dont remain in business very long. It can require a little work to assess which versions offer a suitable power supply, but you dont want a 750W behemoth to run an RX 480 or GTX 970. The reason most hardware review sites additionally contemplate boutique systems is because we understand that being a gaming enthusiast and needing to construct your rig from scratch arent always the same thing and those who are interested in being PC gamers but dont have time to make desktop computers deserve to understand which firms are constructing better or worse systems. Ever since then, Ive built, updated, fixed, and modded more systems than I can recall.


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Seen at Paris Fashion Week: Shadows and Shimmers
Behind the scenes at Rochas, Mugler, Dries, and more in the City of Light.
For our first-ever portfolio from Paris, the Cut sent acclaimed Magnum photographer Alex Majoli to Paris to shoot the final (and arguably most riche) stretch of fashion month. Different from the pop aesthetic of New York, the experimental vibes of London, or the luxe moodiness of Milan, the sensibility of this Parisian set of images veers toward darker, sexier moments mixed with blown-out, fragmented impressions of garments and beautiful women. Click through the slideshow for a dangerous pair of shoes at Anthony Vaccarello, a louche set of red lips at Rochas, the beauties at Dries, and more. And don't forget to zoom in to see the details.BEGIN SLIDESHOW


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Start your career or sharpen your skills in filmmaking by learning from professional filmmakers. Discover cinema-grade cameras, scriptwriting, storyboarding, editing, visual effects and more.
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Hands-on experiences that teach students how to use Autodesk® Maya® and create 3D art for films and games. We take you through the key aspects and fundamentals of 3D art and production.
DMA also offers courses for Teens ages 12-17
Learn more about DMA's Teen Courses »
Student Success Stories
Angus Willows is the type of student we love to see attend DMA: someone who truly wants to use technology to build a better future for everybody. As an active member of "The Maker Generation"… Read more


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Robert Conyers won't visit Ole Miss officially for another two weeks.
Conyers makes choice after early trip to Ole Miss
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StartUpHire is the place to find IT Systems Security Engineer jobs. Review the list of IT Systems Security Engineer career opportunities to the left. These IT Systems Security Engineer jobs represent some of the most rewarding careers available.
You can refine your job search for IT Systems Security Engineer career opportunities by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
Don't see the employment opportunity you're looking for? Check back soon for more IT Systems Security Engineer jobs, or sign up for an email alert (link below) to receive periodic updates on new IT Systems Security Engineer jobs.
We're looking for an Information Assurance Engineer to join a top-notch group supporting world class science and technology at the U.S. Naval Research Laboratory (NRL). Zurka Interactive is expanding our team at NRL in Washington DC.9/26/2016 Washington, DC Save This Job
You are here Home / Systems Security Engineer (Full time; Lehi, UT) Location: Lehi, UT Type: Full-time Experience: Minimum 5 years Linux Systems Administration / Cloud Ops / Mesos Functions: Systems Security Engineer Industries: Computer Software Posted: Ongoing Job9/3/2016 Lehi, UT Save This Job
Responsibilities Our Federal Security Engineering Manager (SE) will be responsible for technically supporting company products and services into Tripwires FEDERAL customers. The successful candidate will work closely with field sales, inside sales, Value Added Resellers,9/3/2016 Portland, OR Save This Job
AVAILABLE LOCATIONS: WILMINGTON, MA; SEATTLE, WA; PUNE, INDIA Position Overview The Security Engineer will join a team of application security experts as they assess the security of software systems for Security Innovation's global client base of technology vendors and9/12/2016 Wilmington, MA Save This Job
Description The security engineer will join a team of application security experts in Security Innovation's Seattle office as they assess the security of software systems for Security Innovation's global client base of technology vendors and enterprise IT organizations.9/12/2016 Seattle, WA Save This Job
Job Description: Analyze the networking and security product requirements of hybrid cloud environments involving enterprise legacy networks. Design and develop software products to address the networking and security requirements of migrating applications to the cloud. Ability9/4/2016 San Jose, CA Save This Job
Location:United States - Houston Department:Security Content Description Alert Logic, the leader in security and compliance solutions for the cloud, provides Security-as-a-Service for on-premises, cloud, and hybrid infrastructures, delivering deep security insight and continuous8/23/2016 Houston, TX Save This Job
at Twilio (View all jobs) San Francisco, CA Twilio Senior Product Security Engineers are responsible for making sure Twilio products meet the highest security standards in the industry. Successful candidates have a strong software development background, have prior experience9/4/2016 San Francisco, CA Save This Job
Job ID 2016-1426 Job Location(s) US-NJ-Hamilton US-CO-Denver More information about this job: Overview: It's not just clich-. The heart of Billtrust is our people. Our executives know it, our co-workers believe it, and our clients recognize it. Billtrust is enjoying remarkable8/23/2016 Hamilton, NJ Save This Job
OAKLAND, CAIT OPERATIONSFULL-TIME APPLY FOR THIS JOB Job Purpose: Are you interested in a role which is responsible for the security of mission critical production systems in a SaaS company that utilizes some of the most advanced technology on the market? Do you enjoy working8/31/2016 Oakland, CA Save This Job
Location:San Diego, CA Job Code:1085 # of Openings:1 Description POSITION: Security Engineer DEPARTMENT: Information Technology (300) REPORTING SUPERVISOR: Director, IT Operations DIRECT REPORTS: No FLSA: Exempt EMPLOYMENT STATUS: Direct Hire TRAVEL REQUIREMENTS: as9/30/2016 San Diego, CA Save This Job
IT ? Hackensack, New Jersey We are currently seeking an Information Security Engineer to join our Information Technology team at our corporate office located in Hackensack, NJ. The Information Security Engineer will act as the technical project lead to implement and support a9/28/2016 Hackensack, NJ Save This Job
Job Details Job Location USA-VA-McLean Description COMPANY OVERVIEW Founded in 2000, Logi Analytics provides businesses the fastest and easiest way to deliver business analytics, dashboards, and reports to a broad range of users, as well as to embed them into existing9/10/2016 McLean, VA Save This Job
Job Description Security Engineer - (01997) Description NOTE: This is a remote position and candidates can be located in Maryland, Northern Virginia, Washington DC, Detroit, or Austin. Depending on location, occasional short trips to Baltimore or Ottawa (Canada) may be9/5/2016 Belcamp, MD Save This Job
Reports to: Security Operations Manager Department: Operations Location: Austin Texas Job Type: Full Time, Exempt Last Updated: 5 July 2016 Summary ClearDATA is looking for a Security Engineer to insure our current hosted offerings are implemented with the highest security8/23/2016 Austin, TX Save This Job
Description: We are looking for a system security engineer, who enjoys security work and possesses both deep and wide expertise in the security space. This position is an individual contributor role with responsibility for infosec across international networks and systems9/12/2016 New York, NY Save This Job
Senior Security Engineer, PlatformApplyHide Responsibilities: Our customers entrust Rescale with their mission-critical engineering designs and it is imperative that we keep the platform as secure as possible. We are looking for a generalist software engineer who has experience,9/6/2016 San Francisco, CA Save This Job
Information Technology Seattle, WA, United States Who: In order to be successful in today?s increasingly mobile environment, companies need secure and ?always on? network connectivity and the tools to maintain it ? that?s where NetMotion comes in. Our intelligent Mobility VPN9/21/2016 Seattle, WA Save This Job
Systems Reliability Engineer (Mandarin Speaking) - San Francisco San Francisco, CA Technical Operations / Network Engineering Job Description At CloudFlare, we have our eyes set on an ambitious goal -- to build a better web. We believe that with our talented team, smart9/17/2016 San Francisco, CA Save This Job
Job Description At CloudFlare, we have our eyes set on an ambitious goal -- to build a better web. We believe that with our talented team, smart technology and engaged users we can solve some of the biggest problems on the web. We already serve more web traffic than Twitter,9/17/2016 San Francisco, CA Save This Job


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After 8 p.m., deputies were called to the 700 block of Riverfront Drive after a resident found a body under a boat on the river.
Authorities called in the Department of Natural Resources dive team and the crime scene technicians.
Investigators at the scene said the body had been in the water for at least a few days.
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Despite Borussia Dortmund winning the Bundesliga last season, not one of their players is on the rather farcical 2011 FIFPro World XI Shortlist, made up of 55 players from across the world.
The nominees for the shortlist were voted for by the 50,000 professional footballers worldwide from the various players' unions which make up FIFPro.
And it seems most of the nominations were merely chosen as many young footballers' idols, more so than who the best and most in-form players in world football at the moment are.
Hence why the unspectacular likes of John Terry, Alessandro Nesta, Lucio, Frank Lampard, Didier Drogba and Gianluigi Buffon have continued to receive nominations.
Here are 10 players who should have been shortlisted.


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Hi I'm Dave
About Me
I'm married and a father of 4. I love running, mountain biking, camping, hiking, swimming - basically anything outdoors. Professionally I'm a software developer and own a small company that has a handful of employees.
Why I am a Mormon
My family is very important to me, and knowing there's a way to be together forever is very appealing and a great goal for us to always work towards. The teachings of this church have led to a lot of happiness and purpose in my life. Mormonism places a very high priority on self-reliance, education, service, responsibility, families, being an active participant in society. I love that everyone in the church is a volunteer and that people just pitch in and help instead of expecting something in return.
Personal Stories
How has your knowledge of the Plan of Happiness changed/benefited your life?
My mother was killed in a car accident a few years ago. As painful as that was, my family and I received a lot of comfort because of our understanding of the plan of happiness - we know she's not gone forever, we're trying to do the things that will ensure we will be reunited with her after this life, and we know that God loves us. We don't always understand why things happen, or the timing of events in our lives, but we know that God does. We also recognize that this life is important, but it is only a tiny slice of our eternal existence.
Which of the Savior's teachings have influenced you in your life?
Everything Jesus Christ did was motivated by love, and any time I read about Him in the scriptures, I'm struck by how much compassion and patience He has. He's so generous and caring, and He sees the best in everyone. I want to be more like that - very slow to criticize and quick to see the potential in people.
How I live my faith
I go to church each week with my family and help out however I can. The church is full of imperfect people, so I feel right at home! I draw strength and encouragement from the experiences of others, and throughout the week I try to be a good Christian.


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