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The second collaborative effort for writers Neill Blomkamp (who also
directed the film) and his wife, Terri Tatchell, "Chappie" draws
heavily for its inspiration from such previous works as "E.T" and
"Short Circuit," though it is far less playful and hopeful than either
of those two films (though it also channels "RoboCop," which is a
little closer in tone).
The setting is South Africa in the not-too-distant future where crime has reached epidemic proportions. The cops are currently being assisted by a fleet of mindless robots and androids in an effort to maintain law and order in the country. Deon (Dev Patel) is an inventor working for a major weapons-developer who's come up with what he thinks is the prototype of a droid with an actual consciousness, one that, for the first time in human and scientific history, can be classified as genuine "artificial intelligence." The trouble is that, before Deon can inculcate him with a strong moral code and, thus, make a model citizen of him, Chappie (voiced by Sharito Cooley) is kidnapped by a trio of street thugs who want to train him to fight against the droids the government is using against them. Soon, a struggle develops between Deon and the bad guys over what kind of moral being Chappie will turn out to be.
"Chappie" is filled with moments of dark humor, but those in search of a sophisticated, timely comedy should be forewarned that the humor in the film consists almost entirely of the naive, innocent Chappie talking and dressing like a streetwise "gangsta'."
Because it's pulling from so many disparate sources, the screenplay never establishes anything close to a consistent tone. Part kid-oriented fantasy, part urban jungle melodrama, part technology-run-amok cautionary tale, and part moral fable about what it means to be human, the film is too childish for adults and too dark and violent for children to leave it with much of an audience.
But if you feel you can somehow bridge that gap between conventions and styles, then "Chappie" just might be the movie for you.
The characters in "Jurassic World" - which should be titled "Will
Humans Never Learn?" - keep telling one another that the paying public
needs ever more elaborate sensations to keep them coming back for more.
Yet, it's hard at times to tell whether they're talking about the
audiences at the park or the audiences for the movie.
This little bit of self-reflective self-awareness on the part of the filmmakers is one of the few interesting things about this fourth entry in a tetralogy that began with the groundbreaking "Jurassic Park" in 1993. The problem is that it's hard to break ground more than once in the same soil, and "Jurassic World" finds no real way to bring anything new to the project.
The movie just keeps playing different variations on the same theme. Thus, instead of "mere" (and, now, apparently passé) full-sized dinosaurs being regenerated out of ancient samples of preserved DNA, we've graduated to "super dinosaurs" being genetically-engineered out of a mixture of all sorts of dino types. All this gene- and species-tampering is taking place at a decade-old amusement park, an improvement, we are told, over the ill-fated one that never quite got off the ground in the 1990s. But humans are humans and playing God, especially for sensation and profit, never ends very well in these sorts of scenarios, so we're primed to buckle our seats and hang on for the ride. We aren't disappointed.
Once we get past that one slight deviation, the plot of "Jurassic World" pretty much replicates the 1993 original, right down to the "unlikely" (though, actually, quite predictable) system malfunction and two lost and imperiled kids having to be saved from becoming Dino-food by an intrepid adult at the park (Chris Pratt plays the role of trainer and dinosaur- whisperer here). In fact, virtually every scene in "Jurassic World" has a corresponding counterpart in "Jurassic Park," only what was once innovative and fresh has now become derivative and stale (apparently, none of the characters here ever seen the original "Jurassic Park" or they wouldn't keep making the exact same mistakes as the previous group).
Pratt has an easygoing, good-ole-boy charm that serves him well in his role as makeshift hero, but Bryce Dallas Howard is given the thankless task of playing a rather insultingly sexist caricature as the manager of the park who's in way over her head when it comes to running the joint, not to mention coping with a crisis of this magnitude (think Kate Capshaw in "Indiana Jones and the Temple of Doom") and is, thus, in constant need of rescuing by the stalwart Pratt.
Under the directorial aegis of Colin Trevorrow, the action scenes and special effects are predictably eye-popping and state-of-the-art - helping to generate the "wow factor" one minimally expects from this series - but the overall air of deja vu that permeates the film keeps this latest dino-blockbuster from being much more than an afterthought in the Jurassic universe.
At the beginning of "Terminator Genisys," you might be forgiven for,
momentarily at least, thinking that you've somehow stumbled into a
remake of the original 1980s sci-fi classic rather than a sequel to it,
mainly because the set-ups to both films are virtually identical to one
As with the original, we have a character (Jai Courtney) from the 21st Century traveling back to the year 1984 in order to try and alter the outcome in the future. Only here, the mission is to SAVE Sarah Connor (Emilia Clarke) - mother of future freedom fighter John Connor (Jason Clarke) - NOT to destroy her. Further complicating matters - as much for the audience as for the characters - is that, once Courtney arrives at his destination in 1984, he finds that the mission itself has greatly changed due to the fact that he has somehow entered into some kind of alternate timeline where Sarah is no longer a helpless victim but a kick-ass fighter who's been raised by a friendly Terminator guardian played by an Arnold Schwarzenegger who gets a second chance at youth courtesy of the magic of CGI (at least for part of the film). Then it's off to 2017, when the alternate-reality rise of the machines and the destruction of mankind is now set to take place (in the original tale, this epochal event occurred in 1997).
If all this sounds super confusing, don't let it get you too frustrated, for that's pretty much par for the course when it comes to these head- scratching, time-bending scenarios - though I do think the screenplay may have bitten off a bit more than it can chew here, piling up irony upon irony to the point where even die-hard "Terminator" fans may begin to feel a mite affronted and manipulated by it all (and non-fans may just throw up their hands in confusion and give up on the whole thing entirely).
All that being said, "Terminator Genisys" turns out to be a considerably better action film than the majority of critics have given it credit for. The storyline, though confusing at times, is, at least, clever and imaginative; the adventure is fast-paced and the special effects reliably state-of-the-art.
But the real reason for watching "Terminator Genisys" is that it affords us the opportunity of once again watching Arnold engaging in the kind of deadpan comic shtick he perfected in this series before he ran off to serve as governor of California for a couple of terms. It's nice to have him - and his poker-faced quips - back where they belong.
*** This review may contain spoilers ***
In "San Andreas," the world's most famous fault ruptures in so
spectacular (and unlikely) a fashion that virtually the entire state of
California is reduced to one heaping pile of ashes and rubble. And as
dams burst and skyscrapers crumble, we're treated to a series of rescue
stories involving characters that, quite frankly, we couldn't care less
But then, again, no one really goes to a movie like "San Andreas" for thoughtful drama or incisive characterization. It's all about the destruction and carnage, and, in that respect, at least, it delivers the goods - with hyperkinetic action scenes and impressive special effects to compensate for some of the corny dialogue, tedious plot lines and scientific illiteracy that pockmark the picture. And don't think there isn't at least a little time carved out for a burgeoning romance and a few stolen kisses amidst all the death and devastation.
Surrounded by thousands of fleeing, panic-stricken extras, the main actors, led by superhero Dwayne Johnson, include Carla Gugino, Paul Giamatti, Archie Panjabi, Ioan Gruffudd, Kylie Minogue, etc., all playing characters straight out of Stereotypes "R" US (there's even an old couple to share one last embrace before they perish together in an epic tidal wave that all but decimates San Francisco).
My favorite moment comes when a seemingly well-versed, well- travelled character describes San Francisco's landmark Coit Tower as "that tall cement nozzle thing on the hill." A few more choice lines like that one, and "San Andreas" might have been a whole lot more fun.
I may be going out on a limb here, but it's probably safe to say that
"Inside Out" is the first mainstream animated feature film to be
entirely centered around a seriously depressed child.
The reason Riley (Kaitlyn Dias) is so depressed is that the personified emotions - Joy (Amy Poehler), Sadness (Phyllis Smith), Fear (Bill Hader), Disgust (Mindy Kaling) and Anger (Lewis Black) - that are responsible for keeping her psyche running smoothly have been seriously flubbing up of late. So much so that Riley runs the risk of experiencing a full mental breakdown if the emotional team can't retrieve all the core happy memories from Riley's childhood that are rapidly slipping away.
Imaginatively conceived by Pete Docter, Meg Lefauve, Josh Cooley and director Ronnie del Carmen, "Inside Out" takes place in two entirely distinct realms: first, in the "real" world, where a young girl has been dragged by her well-meaning but oblivious parents (Kyle MacLachlan, Diane Lane) from Minnesota to their new home in San Francisco; and, second, in the complex inner workings of said child's brain - a place filled with personality islands and memory balls all operated by the aforementioned Emotions from a giant console.
Rare for a movie aimed primarily at children, "Inside Out" is psychologically astute in its observations about human nature while remaining fanciful and childlike in tone and attitude. It explores the things that really matter to a youngster who's suddenly been yanked from a world where everything is comfortable and familiar to one where everything is unsettling and strange. The movie also points out how even the most well-intentioned of adults often fail to take into account children's very real feelings at crucial moments in their lives.
On a technical level, "Inside Out" comes replete with all the visually stunning graphics, fast-paced storytelling, and outstanding voice work that we've long associated with any computer-animated feature produced by Pixar Studios. But it's the less tangible elements of heart and imagination that truly count in this work.
"Pitch Perfect 2" is an extraordinarily lame female-empowerment comedy
that suffers greatly in comparison to the genuinely hilarious "Spy"
that was released at roughly the same time as this wholly unnecessary
sequel to the 2012 original.
The screenplay by Kay Cannon features one thudding line and one misguided concept after another as the girls gear up to compete in an international contest of a cappella singers.
Directed by Elizabeth Banks, this embarrassing misfire wastes the acting talents of Anna Kendrick, Rebel Wilson, Hailee Steinfeld, Brittany Snow, Skylar Astin, Katey Sagal and Anna Camp (and that's just the women in the cast).
To all those responsible for this unfunny fiasco, hang your heads in shame.
Fans of Lassie and Rin Tin Tin will undoubtedly find much to celebrate
in "Max," an old-fashioned a-boy-and-his-dog story updated to reflect
our post-9/11 age.
The boy in this instance is Justin (Josh Wiggins), a disgruntled teen whose older brother, Kyle (Robbie Amell), a Marine who trains dogs to sniff out weapon caches on the field of battle, is killed in Afghanistan. After Kyle's dog, Max, develops a sort of canine version of Post-Traumatic Stress Disorder, the dead man's family dutifully rescues him, assigning Justin the unenviable task of rehabilitating him back to the point where he can interact with humans again without instinctively wanting to rip their throats out. This Justin does with the help of his new friend, Carmen (the charming Mia Xitlali), who knows a thing or two about training challenging dogs.
In addition to his canine-raising duties, Justin has to contend with his tough-as-nails military dad (Thomas Haden Church) and his own innate laziness and cynicism. But with the help of Max, a devoted and kindly mother (Lauren Graham), and the love of a new girlfriend, Justin eventually grows into his manhood, demonstrating that rehabilitation is often a two-way street.
There are any number of touching moments in the screenplay by Sheldon Lettich and co-writer/director Boaz Yakin, which, happily, manages to keep the unavoidable suds down to a minimum. However, even the fine performances (especially by Wiggins) can't overcome an utterly preposterous subplot involving Justin's entanglement with a local gun-running cartel, a storyline that not only comes to dominate the second half of the movie but may make the movie itself somewhat less than appropriate for the youngest members of its intended audience.
Ah well, at least the canine stunt work - kudos to both Max and his trainer on that score - is super impressive throughout.
Cameron Crowe's "Aloha" is at its most interesting when it's focusing
on Hawaiian folklore and legends and the perpetual conflict between the
natives and an American government that is viewed as little more than
an interloper by the islanders. Unfortunately, in the screenplay by
Crowe, this intriguing aspect is largely relegated to the background
while a comparatively banal love triangle takes center stage.
The male point of that triangle is a cynical, morally compromised military contractor played by Bradley Cooper whose return to Hawaii complicates the lives of his ex-girlfriend (Rachel McAdams) and the female Air Force captain (Emma Stone) assigned to be his liaison between the military and the natives on the islands.
While Cooper is trendily worldweary and vulnerable, Stone is upbeat, cutesy and perky to the point of distraction.
Despite an amiable cast that includes Bill Murray, John Krasinski, Danny McBride and Alec Baldwin in supporting roles, there are not a whole lot of buy-in points for the viewer, thanks to insufficiently developed characters and a lack of focus in the storytelling.
Even a nicely executed final scene isn't enough to redeem most of what's come before.
"Avengers: Age of Ultron" raises the age-old question of just how much
freedom we should be willing to sacrifice in order to ensure a lasting
peace. And, as a corollary, how much power should humans be willing to
cede to technology, particularly in the form of artificial
intelligence, to achieve that goal? It's a theme that more than a few
works of science fiction have dealt with over the years.
In this sequel to the box office smash of 2012, Ray Stark, aka Iron Man, has invented a program called Ultron whose purpose is to eliminate the need for war and global conflict altogether. To no one's surprise but Stark's, when the program is prematurely activated, it turns out to have less than noble intentions as it sets about creating a race of cyborg warriors to completely eradicate humans from the face of the planet and to repopulate it with others like himself.
Only the Avengers (embodied by Robert Downey, Jr., Chris Hemsworth, Don Cheadle, Mark Ruffalo, Chris Evans, Scarlett Johansson, Jeremy Remmer, et. al.) can save the day. And save it they do, amidst supercharged action sequences and jaw-dropping special effects.
Stark certainly means well as he sets about essentially eliminating the need for the Avengers at all, but we in the audience know this is a fool's errand from the start for, if successful, there would be no more entries in this highly lucrative franchise. And we certainly couldn't have that, now, could we?
It's been several decades since I last read Thomas Hardy's "Far From
the Madding Crowd" and even longer since I watched the 1967 movie
version thereof, so it's virtually impossible for me to evaluate just
how faithful this latest edition is to either the original source
material or that earlier adaptation (which starred Julie Christie, Alan
Bates, Peter Finch and Terrance Stamp in key roles). It should,
however, be noted that this version runs about an hour less than the
one from the '60s. Take that for what it's worth.
The story revolves around Bathsheba Everdene (Carey Mulligan), a strong-willed 19th Century woman who inherits her uncle's farm on the moors of England, and her complex relationships with three potential suitors: the rugged shepherd, Gabriel Oak (Matthias Schoenaerts); the wealthy, middle aged bachelor, William Boldwood (Michael Sheen); and the dashing but callow army officer, Sergeant Troy (Tom Sturridge). All are in love with her to one degree or another and all present various challenges to her future success and happiness.
As adapted by David Nicholls, a lot of this "Crowd" plays like standard soap opera fare, as Bathsheba flits from one potential beau to another while still trying to maintain at least some semblance of independence in a world that is not exactly supportive of the concept of an independent woman. At times, despite the excellent performances, the character motivations seem strangely lacking, the possible result of trying to cram too much plot into so short a timespan. The result is a story that often feels rushed and disjointed, lacking the smooth transitions one traditionally finds in long-form narratives.
Nevertheless, under Thomas Vinterberg's direction, the bucolic setting, the roiling human passions and the exploration of Victorian Era strictures and morality keep us involved and interested for the duration.
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Creamy leek, potato & ham pie
Nutrition and extra info
- Freezable
Nutrition: per serving (8)
- kcal511
- fat29g
- saturates16g
- carbs43g
- sugars4g
- fibre4g
- protein19g
- salt1.4g
For the pastry
- 120g butter, cut into cubes
Butter is made when lactic-acid producing bacteria are added to cream and churned to make an…
- 300g plain flour, plus extra for dusting
- good pinch of salt
For the filling
- 600g small floury potato, roughly the same size
The world's favourite root vegetable, the potato comes in innumerable varieties. A member of…
- 2 tbsp olive oil
Olive oilol-iv oyl
Probably the most widely-used oil in cooking, olive oil is pressed from fresh olives. It's…
- 1 onion, finely chopped
Onions are endlessly versatile and an essential ingredient in countless recipes. Native to Asia…
- 500g leek, cleaned and roughly chopped
Like garlic and onion, leeks are a member of the allium family, but have their own distinct…
- 3 garlic clove, finely chopped
- 3 tbsp snipped chive
- 150ml half-fat crème fraîche
- 200g Lancashire cheese, grated
- 200g thinly sliced ham (we used Italian cooked ham)
- 1 medium egg, beaten
First, make the pastry. Put the butter in a bowl with the flour and salt. Using your fingertips, rub the butter into the flour until the mixture resembles coarse breadcrumbs. Add about 6 tbsp water to the mixture and use a knife to mix together until you have a firm dough. Cut the dough in half and shape each into a flat disc. Wrap in cling film and put in the fridge while you make the filling.
Put the potatoes in a medium saucepan and cover with water. Bring to the boil and simmer for 5-7 mins until partcooked. Drain well and allow to cool.
Heat the oil in a large saucepan. Add the onion and leeks, and gently cook for 10-15 mins until they are very tender, being careful not to brown them. Add the garlic and cook for a few mins more, then remove from the heat, tip into a bowl and allow to cool. Stir in the chives.
Heat oven to 180C/160C fan/gas 4. Put a baking tray in the oven to preheat. Roll out 1 disc of the pastry on a lightly floured surface to 5mm thick. Use this to line a 24cm round x 4cm deep pie tin, leaving any excess pastry to overhang the tin. Prick the pastry all over with a fork, place on the heated baking tray and bake for 10-12 mins. Return the baking tray to the oven.
Slice the cooled potatoes into very thin rounds. Start to assemble the pie by arranging half of the potatoes in the base, then top with half the leeks, half the crème fraîche dotted over the top and half the cheese. Arrange half the ham on top, then repeat again with all the remaining ingredients.
Roll out the remaining disc of pastry to about a 26cm circle. Brush the top edge of the pastry in the tin with the beaten egg. Lay the circle of pastry over the top and trim the edges, crimping with your fingertips or a fork to seal. Brush all over with the beaten egg and decorate the top with any leftover pastry cut into leaves or a decoration of your choice.
Place on the hot baking tray on the lowest shelf and bake for 45 mins until golden. Set aside for 15 mins to cool in the tin before transferring to a wire rack to cool. Cut into wedges and serve.
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Comments, questions and tips
Comments (2)
I liked the textures and flavours of this pie but following the other comment we used half the filling to the full quantity of pastry and cooked on a pie plate, this seemed like the right ratio. We also did a standard half fat to flour pastry with half butter and half lard. I would definitely make this again, maybe even as pasties. My husband suggested cubing the potatoes and then just mixing all the filling ingredients together rather than faffing around with layers and I think that is a good idea.
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Dr Vince Cable MP attending Regional Conference
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Dr Vince Cable MP, Secretary of State for Business, Innovation and Skills will be speaking at our Regional Conference on 27th October 2012.
Vince Cable will also be joined by Tom Brake MP, Don Foster MP and Sharon Bowles MEP.
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text: The Divide and Conquer! wiki last edited by jeffreyv2512 on 07/09/14 09:54PM View full history Divide -- and Conquer!Susan Richards suddenly faints, prompting the FF to look over he. However, Thing leaves to go spend time with Alicia. Meanwhile, elsewhere the Psycho-Man punishes one of his subordinates for delivering a component to his device to Alicia's home, getting together his minions Shellshock, Ivan, and Live Wire to help recover the device.At Alicia's home, Thing tries to figure out the strange component that was delivered to her apartment. Soon they are attacked by Psycho-Man and his minions who defeat Thing and take the component. Meanwhile, Black Panther leads an army to Panther Island where they briefly get into a battle against the Inhumans. Realizing that they have mutual allies and that Black Bolt brought the Inhumans because he sensed danger. Investigating, they come across the Psycho-Man's base and have to fight off his defenses.Back in New York, Reed Richards announces to the Fantastic team that Sue is pregnant, and the group celebrates. Back on Panther Island, the Inhumans and Black Panther find themselves overwhelmed, so they have Lockjaw bringing the Fantastic Four to the Psycho-Man's base to turn the tide. There they battle their way to Psycho-Man, who reveals to them that he comes from the Microverse and he intends to take over this world with a giant emoto-caster weapon. Soon Psycho-Man is subdued, after being attacked by all the heroes. When Black Panther questions him, they find the Psycho-Man is motionless, upon closer inspection what they thought was Psycho-Man, was really a robot body piloted by a small being.This Is a Plot?Stan Lee and Jack Kirby story The Peerless Power of the Silver SurferSilver Surfer story


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About Our Culture:
At 500 Startups, we believe having fun, moving quickly, taking risks, and learning from mistakes are the keys to building a healthy, successful company. We greatly value entrepreneurial initiative and a can-do attitude, and we always aim for the stars. Our culture is highly collaborative, and distinctly community oriented. Our team of 100+ people manage seed investments in 20 countries and speak over 25 languages. With 10,000 square feet of open-plan office space in the heart of Silicon Valley and San Francisco, we are rapidly growing and looking for team members who bring passion, intelligence, and "do-er" mentality to the mix. To learn more about 500, check out our YouTube channel, our press mentions, and our blog.
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These are the Highest Quality Afrikaans Tutors in Montana, Cape Town. Get Afrikaans Lessons in your home with Teach Me 2 – the Best in Tutoring
Afrikaans is my First Additional Language. Languages are tricky and requires hours of practice as apposed to memorisation.
I grew up in an Afrikaans environment, with both my parents speaking Afrikaans as a 1st or 2nd language, as well as many of my family members. I therefore found Afrikaans to be one of my 'easiest' subjects at school.
I got 86% for my Matric final exam in Afrikaans Second Language. I would feel comfortable tutoring second language students.
Afrikaans is my second language as my father is Afrikaans-speaking so I grew up with speaking it at home. I understand the difficulties of the language and believe that it is beautiful and intricate, and not beyond any student's understanding.
Having tutored Afrikaans before and passing the subject in Matric with distinction, I am confident enough to tutor any pupil in this subject. Also, I understand the language and literature aspects equally well.
I am half Afrikaans and achieved 87% for it in matric (2nd language level)
I have 3 years experience as an Afrikaans tutor. My father is Afrikaans and therefore I have a natural ear for it. I received 86% for Afrikaans First Additional Language in Matric (2011).
I am fully bilingual and received the Afrikaans trophy in Grade 12. I came first in Afrikaans and thoroughly enjoy this subject.
I did Afrikaans 1st additional language in high school, and with an Afrikaans father, I speak it very often. I also find this an easy language and would love to help those struggling with it.
I can speak Afrikaans fluently - at school, I took Afrikaans as a First Additional Language (IEB) and received both the oral and written Afrikaans prizes in Grade 12 whilst obtaining 89% for my final Matric IEB exam.


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The New York Times changed their online headline on this story from "sex charges" to "sexual assault charges" after getting slammed on Twitter. The piece was about the Morehouse student athletes who have been accused of sexual assault. [New York Times]
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Hongqiao Market is within 2 miles (3 km) of XiZhao Temple Hotel while other popular attractions such as Tiananmen Square are within 3 miles (5 km). This 118-room, 4-star hotel has a restaurant along with conveniences like free in-room WiFi and a conference center. Located in central Beijing, the hotel is also near Forbidden City and Temple of Heaven.
Enjoy a bite to eat at Chinese Restaurant, the hotel's onsite restaurant. Satisfy your hunger from the comfort of your room with room service. Buffet breakfast is offered for a fee each morning from 7 AM to 10 AM.
The 118 rooms are air-conditioned and have an array of amenities, including minibars, coffee makers, and free newspapers. LCD TVs come with satellite channels and video-game consoles, and guests can stay connected with free WiFi and wired Internet. Beds sport premium bedding and bathrooms offer hair dryers and free toiletries. Free local calls, free bottled water, and laptop-compatible safes are also available.
Property features
Guests of XiZhao Temple Hotel enjoy access to free WiFi in public areas, a conference center, and a business center. Airport transportation is made easy with an airport shuttle (available on request) for CNY 500 per vehicle one way. A multilingual staff is on hand to assist with dry cleaning/laundry, tours or tickets, and luggage storage. Additional amenities include coffee/tea in a common area, express check-in, and express check-out.
- Free WiFi in rooms and public areas
- Onsite dining
- Business center
- Airport shuttle (fees apply)
XiZhao Temple Hotel15 Xizhaosi Middle Street Chongwen District Beijing Beijing 100006
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. High-speed wireless Internet access is complimentary. This 4-star property offers access to a business center and meeting rooms. For a surcharge, a roundtrip airport shuttle (available on request) is offered to guests. This business-friendly hotel also offers tour/ticket assistance, multilingual staff, and a garden.
XiZhao Temple Hotel is a smoke-free property.
- Airport transportation (surcharge)
- Total number of rooms - 118
- Number of floors - 5
- Breakfast available (surcharge)
- Business center
- Coffee/tea in common areas
- Conference space
- Dry cleaning/laundry service
- Elevator/lift
- Express check-in
- Express check-out
- Tours/ticket assistance
- Free WiFi
- Meeting rooms
- Multilingual staff
- Garden
- Porter/bellhop
- Luggage storage
- Restaurant
- Safe-deposit box at front desk
- Conference center
- Smoke-free property
- Television in common areas
- Wedding services
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Rollaway/extra beds available
Available in all rooms: Free WiFi , Free wired high-speed Internet
Available in some public areas: Free WiFi
Room Amenities
XiZhao Temple Hotel offers 118 air-conditioned accommodations, which are accessible via exterior corridors and feature minibars and laptop-compatible safes. Beds feature premium bedding. LCD televisions come with premium satellite channels and video-game consoles. Bathrooms include shower/tub combinations, bathrobes, slippers, and complimentary toiletries.
This Beijing hotel provides complimentary wired and wireless high-speed Internet access. Business-friendly amenities include desks and complimentary newspapers, as well as phones; free local calls are provided (restrictions may apply). Additionally, rooms include complimentary bottled water and coffee/tea makers. A nightly turndown service is provided and housekeeping is offered daily. Amenities available on request include irons/ironing boards.
- Premium TV channels
- Video-game console
- Premium bedding
- Free newspaper
- Access via exterior corridors
- Air conditioning
- Phone
- Free local calls
- Minibar
- Coffee/tea maker
- Free bottled water
- Daily housekeeping
- Turndown service
- Private bathroom
- Bathrobes
- Free toiletries
- Hair dryer
- Slippers
- Shower/tub combination
- Iron/ironing board (on request)
- Desk
- Rollaway/extra beds available
- Cribs/infant beds available
- Blackout drapes/curtains
- Free WiFi
- Free wired high-speed Internet
- Free dial-up Internet access
- Satellite TV service
- In-room safe (laptop compatible)
- Room service (limited hours)
- Connecting/adjoining rooms available
Where to Eat
Buffet breakfasts are available for a surcharge and are served each morning between 7 AM and 10 AM.
Chinese Restaurant - This restaurant serves lunch and dinner.
Lobby Bar - This café serves breakfast only.
Room service (during limited hours) is available.
To make special requests for accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- Roll-in shower
Hotel Policies
Check-in time starts at noon
Special check-in instructions:
Check-out time is noon
Payment types
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Noise-free rooms not guaranteed
Optional extras
- Fee for buffet breakfast: CNY 88 per person (approximately)
- Airport shuttle fee: CNY 500 per vehicle (one way)
- Rollaway bed fee: CNY 200 per night
Hotel Name
- XiZhao
- XiZhao Temple
- XiZhao Temple Beijing
- XiZhao Temple Hotel
- XiZhao Temple Hotel Beijing
We should mention
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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GLASSBORO — The American Red Cross and the Rotary Club of Glassboro will host their "Starve a Vampire, Donate Blood!" drive on Saturday at VFW Post 679 and they're very much in need of volunteers.
So far, only eight donors have registered online — falling well below the 40-unit goal the rotary has set. Some people have reported being hesitant to donate because they are suffering flu-like symptoms or fear donating blood will lower their immunities to the circulating flu strains, but officials from the American Red Cross say it's safe to donate if you're feeling well.
Interested donors can schedule an appointment at www.pleasegiveblood.org and walk-ins are also welcome.
The VFW is located at 275 Wilmer Street and the drive will be held from 9 a.m. to 3 p.m.


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- 25.1. Overview
- 25.2. Header
- 25.3. Layouts
- 25.4. RenderSets
- 25.5. Themes
- 25.6. Other Theme Functionalities and Features
- 25.7. Theme Style Guide (based on the Industrial theme)
- 25.8. Additional Ajax selectors
Portals usually render the markup fragments of several portlets, and aggregate these fragments into one page that ultimately gets sent back as response. Each portlet on that page will be decorated by the portal to limit the real estate the portlet has on the page, but also to allow the portal to inject extra functionality on a per portlet basis. Classic examples of this injection are the maximize, minimize and mode change links that will appear in the portlet window , together with the title.
Layouts and themes allow to manipulate the look and feel of the portal. Layouts are responsible to render markup that will wrap the markup fragments produced by the individual portlets. Themes, on the other hand, are responsible to style and enhance this markup.
In JBoss Portal, layouts are implemented as a JSP or a Servlet. Themes are implemented using CSS Style sheets, JavaScript™ and images. The binding element between layouts and themes are the class and id attributes of the rendered markup.
JBoss Portal has the concept of regions on a page. When a page is defined, and portlet windows are assigned to the page, the region, and order inside the region, has to be specified as well. For portal layouts this has significant meaning. It defines the top most markup container that can wrap portlet content (other then the static markup in the JSP itself). In other words: from a layout perspective all portlets of a page are assigned to one or more regions. Each region can contain one or more portlets. To render the page content to return from a portal request, the portal has to render the layout JSP, and for each region, all the portlets in the region.
Since the markup around each region, and around each portlet inside that region, is effectively the same for all the pages of a portal, it makes sense to encapsulate it in its own entity.
To implement this encapsulation there are several ways:
- JSP pages that get included from the layout JSP for each region/portlet
- a taglib that allows to place region, window, and decoration tags into the layout JSP
- a taglib that uses a pluggable API to delegate the markup generation to a set of classes
In JBoss Portal you can currently see two out of these approaches, namely the first and the last. Examples for the first can be found in the portal-core.war, implemented by the nodesk and phalanx layouts. Examples for the third approach can be found in the same war, implemented by the industrial and Nphalanx layout. What encapsulates the markup generation for each region, window, and portlet decoration in this last approach is what's called the RenderSet.
The RenderSet consist of four interfaces that correspond with the four markup containers that wrap the markup fragments of one of more portlets:
- Region
- Window
- Decoration
- Portlet Content
While we want to leave it open to you to decide which way to implement your layouts and themes, we strongly believe that the last approach is superior, and allows for far more flexibility, and clearer separation of duties between portal developers and web designers.
The last topic to introduce in this overview is the one of portal themes. A theme is a collection of web design artifacts. It defines a set of CSS, JavaScript and image files that together decide about the look and feel of the portal page. The theme can take a wide spectrum of control over the look and feel. It can limit itself to decide fonts and colors, or it can take over a lot more and decide the placement (location) of portlets and much more.


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Jonathan Dayton vs Cranford in the Union County Tournament game on 2-20-11
Sunday, February 20, 2011 7:28 PM
Inappropriate photo? Alert us.
Cranfords Mar-aid McKearp (13) and Morgan Miller (3) try to defend Anna Lies (15) of Dayton as she drives upcourt in the game between Jonathan Dayton and Cranford at the Union County Girls basketball Tournament game in Rahway, NJ 2/20/11 (William Perlman/The Star-Ledger) TO PURCHASE THIS PHOTO, CALL THE STAR-LEDGER PHOTO LIBRARY AT 973-392-1530


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casinos-jackpot.co.uk The most popular online casino sites offer information .They offer secure online casino games site here you
can find online casinos .in the following casinos recommended here. You can choose any casino, poker, bingo, roulette, baccarat and
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have been written about casinos.


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This set includes full of nu-disco and indie dance sound with a little bit electro bit. I've selected 13 special tracks with interesting vocals and nicely melodys. "Desire" is the best for dance and listen to. Enjoy it and I believe you'll be happy :-)
This comment has been deleted.
Agnieszka Adamczewska3 years agoReplyReport spam
Jak dla mnie jeden z lepszych i chyba moj ulubiony :)
Comment reported as spamThank you for your help!


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We're still early in first-quarter earnings season and Wall Street has already had a nice rally this year. The S&P 500 put on nearly 15% between February 8 and this past Thursday. We could be headed for a cooling off period. Paul J. Lim notes in The New York Times that the market may be getting a tad too optimistic about earnings:
John Butters, an earnings analyst at Thomson Reuters, noted that more often than not, companies that are likely to fall short tend to pre-announce their results, in part to lower the market's expectations.
Historically, two companies pre-announce bad news for every company that hints at better-than-expected results to come. But at the moment, Mr. Butters said, the ratio is just 1.1 to 1 — which means that far fewer companies than usual are preparing the market for disappointment.
That may sound like a positive sign, but it isn't. Oddly, when the pre-announcement ratio has been this low over the last decade, it "corresponds with a decline of about 6 percent in the S.& P. 500 during the earnings season," Mr. Kleintop said. It may be that without an early warning of trouble, investors become too ebullient, leading to market declines later.
Here's a look at the S&P 500 along with its earnings. The S&P 500 is the black line and it follows the left scale. The earnings are the yellow line and they follow the right scale. The two lines are scaled at a ratio of 16-to-1, so whenever the lines cross, the P/E Ratio is exactly 16.
The future earnings are, of course, just a forecast. Be careful not to read too much into this chart. The point I want to show you is that the market has rallied and it's been due to a surge in earnings that's expected to continue.
If that yellow line continues its sharp upward trend, then the market is still very cheap and we have nothing to worry about. We ought to assume that the black and yellow lines will converge over time.
The hitch is that this is all predicated on a very strong earnings environment. We shall know more when we're a little older.


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realmagick.com The shrine of knowledge.
- any of various devices for measuring minute distances, angles, etc., as in connection with a telescope or microscope. 2.
- Leap day, giant viruses, and gene-editing
- Mimiviruses are huge. At almost half a micrometre in diameter, they are big enough to be viewed with a light microscope.
- Interference at a double slit made of two atoms
- Although the resolution of the imaging system limits the size of the atom images to 1.
- CRISPR-like 'immune' system discovered in giant virus
- Around half a micrometre across, and first found infecting amoebae living in a water tower, they boast genomes that are larger than those of some bacteria.
- Understanding Graphene - Part 2
- The size of the graphene monolayer is determined by the flake size in the original sample. Typical flake sizes are around 2000 micrometres (µm or micron) the largest graphene monolayer flake size found so far is 1,500,000 square micrometres.
Micrometre is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Micrometre books and related discussion.
Suggested News Resources
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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Orange Ginger Sauce
Total Time
Prep 10 mins
Cook 3 mins
Great on broiled or grilled salmon..... shrimp??? chicken??? beef??? Oh, the possibilities!
Ingredients Nutrition
- 1⁄4 cup orange juice (I prefer fresh squeezed but use what you like)
- 2 teaspoons ginger juice (from a 2 inch piece of fresh ginger)
- 1 tablespoon cilantro, fresh, chopped
- 1⁄2 teaspoon sesame oil
- Coarsely grate a 2-inch piece of unpeeled ginger. Gather the gratings into a little ball and squeeze tightly. (This should produce 2 - 3 teaspoons of fresh ginger juice.).
- Place all ingredients in a small saucepan and mix well.
- Bring the sauce to a boil just before serving.
- Spoon over your favorite thing!
Most Helpful
We had this for dinner tonight and both thought it was light and delicious. thanks for sharing


text: Ben Annand Ben Annand Redondo Beach I hope you enjoy my music and how I mix it. For bookings contact email@example.com Upcoming Schedule July 30 Turnt n Twisted (City hearts afterparty)- LA, CA Aug 5-6 Denver Summer Showcase - Denver, CO Aug 12 Tropical Boat Party w/Doc Martin, Mark Quark, Wally Callerio - LA, CA Bio: Ben Annand has been a mover and shaker in the house and techno scene in Los Angeles since he first started djing in 1996. He holds dj residencies at 3 of California's top parties – Tropical and Moontribe in the L.A. area, and Forward in San Francisco. He has played in most major U.S cities, and internationally in Japan, Russia, England, Scotland, Spain, Portugal, Canada, Ecuador, and Mexico. Highlights include Wiggle at Fabric in London, 2 times at Labyrinth Festival in Japan, and 14 visits to Moscow's Propaganda Club. Equally dedicated to throwing quality events, Ben is just as known for his event organization as his dj skills. His now legendary party, Tropical, has evolved since 1998 over nearly 60 events from warehouse to boat to beach party to today's campouts, retreats and festivals. Tropical stands out from other parties in that it is 100% nonprofit – the party has raised over $18,000 for charity causes to date. The party is also special for its spectacular locations, including a 160-acre retreat center with poolside Function One Sound system and hot tubs, the stunning La Jolla Indian Reservation, the Hummingbird's Nest Mansion, and Altadena's historic Zorthian Ranch. For booking info please contact firstname.lastname@example.com Ben Annand's tracks Ben Annand Live at the Re: Love Retreat August 27, 2016 by Ben Annand published on 2016/08/30 01:12:40 +0000 Ben Annand Live at In: Codes June 4, 2016 by Ben Annand published on 2016/08/23 18:28:14 +0000 Ben Annand Live in LA at Turnt N Twisted July 31, 2016 by Ben Annand published on 2016/08/01 20:04:03 +0000 Ben Annand "No Laptop Required" - Live at Cure and The Cause May 26, 2016 by Ben Annand published on 2016/06/13 15:22:27 +0000 Ben Annand at TK Spring Gathering, May 14, 2016 by Ben Annand published on 2016/05/17 00:57:53 +0000 Ben Annand Live NYC April 5, 2016 by Ben Annand published on 2016/04/20 21:57:03 +0000 Live in Mexico - Bara Bara Club, Puerto Morelos Jan 16, 2016 by Ben Annand published on 2016/01/29 23:40:07 +0000 Ben Annand Live at Tropical Oasis New Year's Retreat - Midnight Set by Ben Annand published on 2016/01/12 02:12:03 +0000 Ben Annand Live at Howl Portland Oct 31, 2015 by Ben Annand published on 2015/11/05 15:54:33 +0000 Ben Annand live at Fire Fall X, Humboldt County outdoor, 10/24/15 by Ben Annand published on 2015/10/27 00:17:34 +0000


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Ca2+ entry mode of Na+/Ca2+ exchanger as a new therapeutic target for heart failure with preserved ejection fraction
Aims Left ventricular (LV) fibrosis and stiffening play crucial roles in the development of heart failure with preserved ejection fraction (HFPEF). Plasma level of digitalis-like factors (DLFs) is increased in patients with hypertension, a principal underlying cardiovascular disease of HFPEF. Digitalis-like factors inhibit ion-pumping function of Na+/K+-ATPase and activate the Ca2+ entry mode of Na+/Ca2+ exchanger (NCX). Digitalis-like factors are known to promote collagen production in fibroblasts. The aim of this study was to explore whether the pharmacological inhibition of the NCX entry mode is effective in the prevention of LV fibrosis and in the development of HFPEF.
Methods and results (i) Dahl salt-sensitive rats fed 8% NaCl diet from age 6 weeks served as hypertensive HFPEF model. In this model, 24 h urine excretion of DLFs was greater than that in the age-matched control at compensatory hypertrophic and heart failure stages. (ii) Continuous administration of ouabain for 14 weeks developed LV fibrosis without affecting blood pressure in Sprague–Dawley rats. (iii) Ouabain elevated intracellular Ca2+ concentration through the entry of extracellular Ca2+, increased the phosphorylation level of p42/44 mitogen-activated protein kinases, and enhanced 3H-proline incorporation in cardiac fibroblast; and SEA0400, the inhibitor of the NCX entry mode, suppressed these effects. (iv) In the HFPEF model, administration of SEA0400 at subdepressor dose improved the survival rate in association with the attenuation of LV fibrosis and stiffening.
Conclusion Digitalis-like factors and the subsequently activated NCX entry mode may play an important role in the development of hypertensive HFPEF, and the blockade of the NCX entry mode may be a new therapeutic strategy for this phenotype of heart failure.
- Heart failure
- Diastole
- Fibrosis
- Na+/Ca2+ exchanger
- Digitalis-like factors
Heart failure with preserved ejection fraction (HFPEF) has poor prognosis and its prevalence has increased over the past two decades.1 In spite of its socioeconomic burden, therapeutic strategy has not been established. The progression of left ventricular (LV) stiffening plays a crucial role in the transition from asymptomatic LV hypertrophy to HFPEF2 and is attributed to myocardial fibrosis.3 Thus, LV fibrosis is likely a therapeutic target for HFPEF.
Digitalis-like factors (DLFs), such as ouabain and marinobufagenin, exist in humans. The elevation of plasma level of ouabain was observed in patients with hypertension,4 a principal underlying cardiovascular disease of HFPEF.1 Digitalis-like factors promote collagen production in fibroblasts, and the activation of p42/44 mitogen-activated protein kinases (MAPKs) plays an important role in collagen synthesis.5,6 Previous in vitro studies have reported DLFs-induced the activation of Src-p42/44 MAPKs pathway through non-pumping function of Na+/K+-ATPase signalosome.5,7 However, the binding of DLFs to Na+/K+-ATPase also leads to the inactivation of its ion-pumping function, and the Na+-lag hypothesis assumes that this process increases intracellular Na+ concentration and subsequently raises intracellular Ca2+ concentration ([Ca2+]i) through the change in the mode of Na+/Ca2+ exchanger (NCX) from Ca2+ exit (forward) to entry (reverse) mode.8 Kometiani et al.9 demonstrated that the increase in [Ca2+]i leads to the activation of p42/44 MAPKs in myocytes, although another study showed contradictory results.10 The relation among these factors is unknown in fibroblast.
We hypothesized that DLFs are one of risk factors for the development of HFPEF, and this study aimed at exploring whether the pharmacological inhibition of the Ca2+ entry mode of NCX is effective in preventing the development of LV fibrosis and the transition to hypertensive HFPEF.
This study consists of following in vivo and in vitro studies, and details are provided in the supplementary data.
Study 1: Urinary excretion of DLFs in the HFPEF model.
Study 2: Effects of ouabain on cardiac structure.
Study 3: Effects of ouabain and the NCX inhibitor on cardiac fibroblast.
Study 4: Effects of NCX inhibitor on the HFPEF model.
Study 1: Urinary excretion of digitalis-like factors in the HFPEF model rats
At the age of 19 weeks of the HFPEF model, the ratio of LV mass to tibial length and the ratio of lung weight to tibial length were increased without the decrease in LV endocardial or mid-wall fractional shortening or the changes in LV end-diastolic dimension (Table 1). Thus, the HFPEF model of this study protocol represented the characteristics of the hypertensive HFPEF model as published in the previous studies.2,11 Urinary excretion of ouabain-like immunoreactivity was significantly higher in the HFPEF model than in the age-matched control at the age of 13 and 19 weeks (Figure 1A). Urinary excretion of marinobufagenin-like immunoreactivity also increased at the age of 13 weeks and tended to be high at the age of 19 weeks in the HFPEF model rats when compared with the age-matched control (Figure 1B).
|Control (n= 6)
|HFPEF model (n= 6)
|Systolic blood pressure (mmHg)
|129 ± 3
|232 ± 13*
|LV end-diastolic dimension (mm)
|9.3 ± 0.2
|9.0 ± 1.0
|LV posterior wall thickness at end-diastole (mm)
|1.2 ± 0.1
|1.7 ± 0.1*
|LV endocardial fractional shortening (%)
|28 ± 2
|27 ± 4
|LV mid-wall fractional shortening (%)
|17 ± 1
|15 ± 3
|A ratio of LV mass to tibial length (mg/mm)
|20 ± 1
|31 ± 2*
|A ratio of lung weight to tibial length (mg/mm)
|35 ± 2
|53 ± 17*
Values are expressed as mean ± SD.
HFPEF, heart failure with preserved ejection fraction; LV, left ventricular.
*P< 0.05 vs. control group.
Study 2: Effects of ouabain on cardiac structure in Sprague–Dawley rats
There was no significant difference in systolic blood pressure, echocardiographic parameters, or a ratio of LV mass to tibial length between the ouabain and the control groups; however, LV area of fibrosis was significantly greater in the ouabain group than in the control group irrespective of NaCl concentration of chow (Table 2, Figure 2).
|Low-salt diet
|High-salt diet
|Control (n = 4)
|Ouabain (n = 6)
|Control (n = 4)
|Ouabain (n = 6)
|Systolic blood pressure (mmHg)
|128 ± 7
|130 ± 1
|130 ± 7
|129 ± 11
|LV end-diastolic dimension (mm)
|8.5 ± 0.5
|9.0 ± 0.3
|9.5 ± 0.3
|9.2 ± 0.3
|LV posterior wall thickness at end-diastole (mm)
|1.4 ± 0.2
|1.4 ± 0.1
|1.5 ± 0.1
|1.6 ± 0.1
|LV endocardial fractional shortening (%)
|38 ± 6
|35 ± 2
|39 ± 6
|36 ± 3
|LV mid-wall fractional shortening (%)
|21 ± 4
|19 ± 1
|21 ± 2
|20 ± 2
|E/A ratio
|1.9 ± 0.4
|1.9 ± 0.8
|1.6 ± 0.3
|1.5 ± 0.1
|Deceleration time of mitral E-wave (ms)
|46 ± 6
|45 ± 4
|53 ± 6
|55 ± 4
Values are expressed as mean ± SD.
E/A ratio, a ratio of peak early diastolic filling velocity to peak filling velocity at atrial contraction.
Study 3: Effects of ouabain and SEA0400 on cardiac fibroblast
Intracellular Ca2+ dynamics
In normal PSS (control), the fibroblasts responded to bath-applied ouabain with robust Ca2+ transient (Figure 3A and D). This Ca2+ signal was completely diminished by removal of Ca2+ from extracellular PSS (Figure 3B and D). Furthermore, SEA0400, an NCX inhibitor that preferentially blocks the Ca2+ entry mode,12 substantially suppressed the ouabain-induced elevation of [Ca2+]i (Figure 3C and D). In quite contrast, Ca2+ release stimulated by angiotensin II normally occurred in the absence of extracellular Ca2+, or in the presence of SEA0400 (Figure 3A–C). These results suggest that the ouabain-induced elevation of [Ca2+]i is largely attributed to the Ca2+ entry mode operation of the NCX.
3H-proline incorporation and p42/44 mitogen-activated protein kinase activity
3H-proline incorporation (Figure 4A) and the phosphorylation of p42/44 MAPK (Figure 4B) were promoted by ouabain administration in cardiac fibroblasts. SEA0400 suppressed these effects of ouabain, but did not affect the baseline levels.
Study 4: Effects of Na+/Ca2+ exchanger inhibitor on HFPEF model rats
Survival study
The administration of SEA0400 improved the survival rate of the HFPEF model (Figure 5A). All of the rats of the untreated group which died during the protocol were associated with pulmonary congestion. There were no differences in systolic blood pressure (P= 0.056–0.801) or heart rate (P= 0.091–0.689) between the two groups at any age (Figure 5B and C).
Haemodynamic and pathophysiological study
Before data collection, 5 of 14 rats in the untreated group and 2 of 12 rats in the SEA group died with pulmonary congestion. We could not collect data in one rat of the untreated group and two rats of the SEA group because of technical failure in the process of cardiac catheterization. Therefore, data from eight rats in the untreated group, eight rats in the SEA group, and eight rats in the control group were analysed. All echocardiographic and haemodynamic data are summarized in Table 3. Systolic blood pressure, heart rate, LV mid-wall fractional shortening, LV end-diastolic dimension, the ratio of LV mass to tibial length, and the time constant of LV relaxation were not different between the untreated group and the SEA group. However, myocardial stiffness constant, LV end-diastolic pressure, and the ratio of lung weight to tibial length were significantly lower in the SEA group than in the untreated group.
|Control group (n= 8)
|Untreated group (n= 8)
|SEA group(n= 8)
|P-value for NO difference
|Systolic blood pressure (mmHg)
|128 ± 7
|217 ± 12*
|211 ± 10*
|LV end-diastolic dimension (mm)
|9.7 ± 0.7
|10.6 ± 0.8
|10.3 ± 0.7
|LV posterior wall thickness at end-diastole (mm)
|1.1 ± 0.1
|1.7 ± 0.1*
|1.5 ± 0.1*,**
|LV endocardial fractional shortening (%)
|27 ± 3
|28 ± 7
|30 ± 6
|LV mid-wall fractional shortening (%)
|16 ± 2
|14 ± 3
|16 ± 3
|LV end-diastolic pressure (mmHg)
|5 ± 5
|17 ± 7*
|9 ± 5**
|Time constant of LV relaxation (ms)
|18 ± 2
|34 ± 12*
|28 ± 3*
|Myocardial stiffness constant
|2.9 ± 0.6
|7.0 ± 1.4*
|5.5 ± 1.4*,**
|A ratio of LV mass to tibial length (mg/mm)
|21 ± 3
|32 ± 2*
|31 ± 3*
|A ratio of lung weight to tibial length (mg/mm)
|36 ± 2
|84 ± 22*
|52 ± 16**
Values are expressed as mean ± SD.
*P< 0.05 vs. control group.
**P < 0.05 vs. untreated group.
The area of LV fibrosis was greater in the untreated group than in the control group (Figure 6). The mRNA level of type I collagen was increased by 5.7-fold (P< 0.05), and the hydroxyproline content of LV myocardium was higher in the untreated group than in the control group (4.6 ± 0.7 vs. 3.3 ± 0.5 μmol/g, P< 0.05). The administration of SEA0400 reduced the area of LV fibrosis (Figure 6) in association with the significant decrease in type I collagen mRNA level by 21% (P< 0.05). Left ventricular hydroxyproline content in the SEA group (4.2 ± 0.4 μmol/g) tended to be decreased when compared with the untreated group, although the difference was not statistically significant. The activity of 72 kDa gelatinase (matrix metalloproteinase-2) was significantly enhanced in the untreated group compared with the control group and was attenuated in the SEA group (Figure 7).
The principal findings of the present study are (i) daily urinary excretion of DLFs was increased at compensated hypertrophic and heart failure stages in the HFPEF model, (ii) chronic administration of ouabain promoted cardiac fibrosis without the elevation of blood pressure irrespective of NaCl loading, (iii) ouabain elevated [Ca2+]i through the entry of extracellular Ca2+, and enhanced collagen production with the activation of p42/44 MAPK in cardiac fibroblast, (iv) SEA0400 suppressed these in vitro effects of ouabain, (v) SEA0400 attenuated LV fibrosis and stiffening without the anti-hypertensive effects and prevented pulmonary congestion and the increase in LV filling pressure in hypertensive HFPEF model rats, leading to the improvement of survival rate.
The prevalence of HFPEF has increased, and its prognosis has not improved during the past two decades.1 Experimental and clinical studies have shown that LV fibrosis plays a crucial role in the development of HFPEF,2,3,13 indicating that LV fibrosis is a therapeutic target for this phenotype of heart failure. Although experimental and small-sized clinical studies have suggested the efficiency of angiotensin receptor blocker or angiotensin-converting enzyme-inhibitor in the prevention of LV fibrosis and/or HFPEF,11,14,15 clinical trials have failed to show the reduction of the primary outcome by these drugs.16,17 Thus, another target to prevent fibrosis is awaited to improve the prognosis of HFPEF.
Digitalis-like factors bind to Na+/K+-ATPase and subsequently result in the change of the mode of NCX and the increase in [Ca2+]i.8 Previous experimental studies have shown that DLFs activate MAPKs and promote collagen production in fibroblasts.5,7 Plasma level of DLFs is elevated in a half of patients with hypertension4 and also increases in association with the reduction of ejection fraction18 or physical stress situations.19,20 This study showed that the urinary excretion of DLFs was augmented in the hypertensive HFPEF model at compensatory hypertrophic and heart failure stages, which suggests the enhanced secretion of DLFs and the elevation of their plasma level in HFPEF.21 A close relation between DLFs and the elevation of blood pressure has been reported,7,22 but the current study demonstrated that ouabain induced collagen synthesis in vitro and promoted LV fibrosis in vivo without the induction of hypertension. The dose of ouabain in our in vitro study, Study 3, was likely above the physiological range, considering its plasma concentration.4 This dose was chosen on the basis of the previous studies5,23 to clarify the effects of ouabain without loss of viability and those of SEA0400 on ouabain-induced phenomenon. The dose of exogenous ouabain in our in vivo study, Study 2, was determined on the basis of the previous study,24 and its tissue or plasma concentration was not assessed in this study. Although this study may not necessarily reproduce the effects of ouabain at its physiological concentration, the current data suggest that DLFs can induce LV fibrosis through the direct pathway in cardiac tissue, and that the blockade of this pathway is a therapeutic strategy for hypertensive HFPEF independent of anti-hypertensive effects.
Previous in vitro studies have shown that DLFs promote collagen production in fibroblasts through the non-pumping function of Na+/K+-ATPase signalosome,5,7 and this signalling cascade has been considered to lead to the activation of Src and p42/44 MAPK.5 Liu et al.6 reported that the activation of p42/44 MAPK is mandatory in transforming growth factor-β-stimulated collagen synthesis in cardiac fibroblast. These studies suggest that DLFs-induced stimulation of non-pumping function of Na+/K+-ATPase is responsible for the enhancement of collagen production. Digitalis-like factors also inhibit pumping function of Na+/K+-ATPase and increase intracellular Na+ concentration, which in turn raises [Ca2+]i through the entry mode of NCX8; however, a previous study showed that the increase in [Ca2+]i was secondary to the activation of p42/44 MAPK in myocytes.10 If so in fibroblast, the blockade of the entry mode of NCX may not lead to the inhibition of p42/44 MAPK and collagen production. This study showed that the ouabain-induced increase in [Ca2+]i was due to the influx of extracellular Ca2+ through the entry mode of NCX, and that the blockade of the entry mode with SEA0400 attenuated the phosphorylation level of p42/44 MAPK and the collagen synthesis as well as the increase in [Ca2+]i. These results suggest that DLFs activate p42/44 MAPK and promote collagen synthesis in fibroblasts at least partly through the inhibition of pumping function of Na+/K+-ATPase and the secondary promotion of the entry mode of NCX. The entry mode of NCX also enhances migration, contraction, and proliferation of fibroblasts.25 Thus, the blockade of the entry mode of NCX can be expected to inhibit tissue fibrosis in the condition with enhanced secretion of DLFs.
This study demonstrated that the secretion of DLFs was enhanced in an animal model of hypertensive HFPEF, and that the chronic administration of SEA0400, an inhibitor of the NCX entry mode,12 attenuated LV fibrosis and myocardial stiffening, inhibited the elevation of LV filling pressure and pulmonary congestion, and improved the survival rate of this model. Iwamoto et al.8 reported the depressor effects of SEA0400 in Dahl salt-sensitive rats fed on high-salt diet. We used a low dose of SEA0400 to avoid its anti-hypertensive effects and demonstrated that SEA0400 provided the beneficial effects even without the changes in systolic blood pressure. Thus, the blockade of the entry mode of NCX is likely a new therapeutic strategy for the prevention of LV fibrosis, LV stiffening, and HFPEF, and our results suggest that the attenuation of LV fibrosis is provided through the inhibition of collagen synthesis rather than through the enhancement of collagen degradation. Previous studies have suggested that the entry mode of NCX has protective effects on LV systolic function in patients and animals with reduced ejection fraction.26 However, the administration of SEA0400 did not alter LV endocardial and mid-wall fractional shortenings in HFPEF model rats (Table 3), suggesting that the chronic blockade of the entry mode of NCX does not provide adverse effects on systolic function in HFPEF.
Current guidelines for the treatment of heart failure recommend the use of digitalis in patients with reduced ejection fraction to decrease hospitalization for worsening heart failure. Digitalis Investigation Group (DIG) trial showed that digitalis did not reduce mortality of heart failure patients irrespective of ejection fraction but was not inferior to placebo,27 indicating that digitalis does not provide adverse effects. The current results suggest the adverse effects of digitalis and are likely discrepant from the clinical studies. However, a post hoc analysis of DIG trial demonstrated that high serum digoxin concentration was associated with an unadjusted increase in all-cause mortality, whereas low serum digoxin concentration was associated with its decrease.28 Thus, the adverse effects of DLFs may be exerted in association with the increase in their tissue/serum concentration, which is partly compatible with the current results. Another explanation is that the effects of all of DLFs are not the same.29 Some of DLFs provide counteractive effects against other DLFs. Thus, the effects of exogenous digitalis may not mimic those of endogenous DLFs.
Study limitation
First, the chronic administration of ouabain promoted myocardial fibrosis in Study 2, but we did not directly assess the effects on LV diastolic function. Our previous study showed that myocardial fibrosis proportionally promotes myocardial stiffening,3 suggesting that ouabain exacerbated diastolic function in Study 2. Elkareh et al.7 demonstrated that marinobufagenin, one of DLFs, induced myocardial fibrosis and diastolic dysfunction. The administration of ouabain did not change indices of transmitral flow velocity curves (Table 2); however, they are insensitive to changes in diastolic function in subjects with preserved ejection fraction.30 Therefore, the results of Study 2 may not contradict our conclusion. Second, the increase in LV stiffness of HFPEF is provided by myocyte stiffening as well as interstitial fibrosis.13 SEA0400 modulates the amplitude of the intracellular Ca2+ transient and myocyte contractility.31 However, we did not assess the effects of DLFs and SEA0400 on myocyte stiffness, and thus, the beneficial effects of SEA0400 may not be attributed solely to the attenuation of LV fibrosis. Third, we used Dahl salt-sensitive rats fed on high-salt diet as the hypertensive HFPEF model. Exogenous salt loading and an increase in extracellular Na+ concentration may directly increase intracellular Na+ concentration and induce the NCX entry mode independent of DLFs. However, the decrease, not the increase, in the extracellular Na+ concentration elevated [Ca2+]i through the NCX entry mode.25 The profibrotic effects of ouabain were not masked by high-salt intake (Figure 2). Exogenous salt loading may not directly cause the NCX entry mode. Fourth, SEA0400 has been reported as the most potent and selective inhibitor of NCX.12 However, SEA0400 depressed Ca2+ transients even in the absence of NCX.32 Therefore, we cannot completely exclude the possibility that in vivo efficiency of SEA0400 was provided through mechanisms other than the blockade of DLFs-induced NCX entry mode. Fifth, the administration of SEA0400 was initiated at the compensatory hypertrophic stage without LV fibrosis,2 and this study showed the preventive, not therapeutic, effects against LV fibrosis. Left ventricular fibrosis is usually highly prevalent in human HFPEF by the time of diagnosis. To assess the therapeutic effects of the blockade of the entry mode of NCX, future studies are required.
The secretion of DLFs was enhanced in the hypertensive HFPEF model. Ouabain activated p42/44 MAPKs and enhanced collagen production with the elevation of [Ca2+]i via the NCX entry mode. SEA0400, the potent inhibitor of the NCX entry mode, attenuated the development of LV fibrosis and stiffening, and prevented the transition to HFPEF with the improvement of survival rate in the animal models. Thus, DLFs and the subsequently activated the Ca2+ entry mode of NCX may play important roles in the development of LV fibrosis and hypertensive HFPEF, and the blockade of the entry mode of NCX may be a new therapeutic strategy for this phenotype of heart failure. This study was conducted in a rat model for hypertensive HFPEF, and future studies in large animal models or humans are awaited to confirm the clinical relevance of the current findings.
Supplementary material
Supplementary material is available at European Heart Journal online.
This study was supported by grants from the Japan Society for the Promotion of Science (Tokyo, Japan) and the Ministry of Education, Culture, Sports, Science and Technology (Tokyo, Japan).
Conflict of interest: none declared.
The authors are grateful to Satoshi Kurihara, MD, PhD, Norio Fukuda, PhD, Takako Terui, MD, PhD (The Jikei University School of Medicine), and Yoshihisa Kurachi, MD, PhD (Osaka University Graduate School of Medicine) for their invaluable comments. The authors are grateful to Ms Saori Nanbu for the excellent technical assistance of the experiment.
↵† These authors contributed equally to this work.
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: email@example.com


text:
Fondue, chili spots offer welcome warm-ups
We've had below-zero wind chills; we've had blizzard conditions. What we need now is a little comfort - the kind of comfort that can be found around a bubbling pot of fondue, or a steaming bowl of chili.
That brings me to a couple of niche restaurants - the August Weber Haus in Cedarburg, a fondue restaurant in a cozy 19th-century house, and Chili Lili's, a modern-day chili parlor in the Third Ward that emphasizes from-scratch cooking.
August Weber Haus
We're settled in the small, red dining room, basking in the heat that the table's cooktop throws off. Condensation rolls down the fogged windows of this Civil War-era home; it's cold outside but comfy inside the August Weber Haus. It's the start of a pleasant, leisurely night.
Fondue's the thing here: cheese for appetizers, seasoned broth for cooking main-dish meats and seafood, chocolate for dessert.
Not every appetizer is melted, simmered and dunked at the table, though, and that allows for a bite at the bar or on the patio in summer. Olive tapenade on crostini ($10) layered with four kinds of olives, like briny green and earthy kalamata, over cream cheese with garlic, for instance. A fresh salad ($7) drew its flavor from a balanced apple vinaigrette, dried cranberries and bacon, and the soup of the day ($8 for a bowl) - potato with diced ham - tasted genuine, made from scratch.
Traditional Swiss cheese fondue ($12) is one of the bubbling appetizers, but I loved the freewheeling variations - like the German ($13), with smoked Gouda and Swiss melted with the Bavarian dark beer Spaten Optimator; or the Spice ($13), zesty with pepper jack, cheddar and a bit of jalapeño. For dipping, the Spice is served with green bell pepper and cubed bread, given a dash of color with chili powder.
That's typical of the attention to presentation at August Weber Haus. Entrées - cubes of meat or seafood - are laid out with geometric precision. The August Goes to Sea platter ($49) holds ruddy ahi tuna, paired with soy-wasabi sauce; lemon-pepper chicken, with honey mustard sauce; marinated tenderloin, with red wine-blue cheese sauce; and a small lobster tail, with clarified butter. (That tuna at one dinner tasted almost metallic; I wondered if it was at odds with my drink. It was fine on the next visit.)
The other entrées are strictly surf - the Sea ($48) - or turf - the Weber ($43).
Armed with a pair of fondue forks and instructions on how long to submerge the various meats, we started cooking and chatting. This is, by its nature, a leisurely dinner. When it takes a minute or three to cook your next bite of food, you can't rush it. Owner Jake Banas said by phone that dinner typically lasts 2 ½ hours, meaning a table turns no more than once a night.
Fondue, you could say, is doing a public service on two fronts: Not only does the pace encourage relaxation and conversation - there's just something so companionable about the communal nature of fondue - but eating slowly means we tend to eat less, too.
So the menu's advice that each fondue pot serves two could be followed by "or so." Particularly if you and your companions are planning on an appetizer and dessert, one entrée could do for four moderate appetites. It will keep the tab in check, too.
Desserts are good and gooey - Dark Chocolate Caramel Delight ($13), for one, is melted with chopped cashews and other nuts and a bit of port. The vehicles for dipping look like a still life: This platter was adorned with banana, apple and strawberries, little pretzels, cubes of pound cake and mini cream puffs, a raspberry or two, artistic flourishes of chocolate sauce.
A table at August Weber Haus, which opened in 2007, can be hard to land; there are only four of them in the small dining room, and another cooktop is sunk into the bar. Although diners could wait at the bar until a table frees up, the wise will make reservations.
About that small dining room: Diners having a particularly good time can make the room ring with chatter and laughter. It's close quarters, with sound bouncing off the plaster walls.
Settling on stars for a fondue restaurant is vexing - how many to give when the diners, after all, do a fair amount of the "cooking"? But the relaxing, convivial dinners at August Weber Haus were among my most pleasurable of the year.
Chili Lili's Chili Bar
Say "chili" in different parts of the country and it means different things. Beans, no beans. Tomato, no tomato. Chilies, no chilies.
Chili Lili's Chili Bar in the Third Ward takes its chili seriously, with authentic versions of Cincinnati and Texas styles. For good measure, it serves several other kinds of chili, too. None is your typical bowl of red.
The chili-centric menu isn't kidding when it lists "all things chili." Even the salads come with chili vinaigrette and chili ranch.
You won't find appetizers listed per se, but chili nachos will work for a little pre-dinner nosh; so will crisp, seasoned waffle fries topped with chili. That's Cincinnati-style chili - pure ground beef given depth with cinnamon and other spices.
That Cincy chili also is administered via the classic delivery system: three-way (over spaghetti, topped with grated cheddar; $8), four-way (add onions or beans; $9) or five-way (add onions and beans; $9.50). It's a serious plateful.
Chilies and locally brewed stout infuse the classic, beanless Texas chili, with its chunks of beef stewed until tender. A bowl ($5) is right-sized for lunch, but at dinner tables held mainly platters of chili - over lavish slices of garlic toast or big, fresh squares of cornbread ($8), or over macaroni and cheese, baked with cheddar ($8).
After the classics, Chili Lili's has some fun. Buffalo-style chili was addictively tasty; chicken, white beans, hot sauce and blue cheese really do play well together. Another chicken chili summons Southwestern flavors.
Spicy Pizza Chili wasn't so much spicy as salty - inevitable when sausage, pepperoni and olives combine. Vegetarian chili, a promising mix with Portobello mushrooms, eggplant and squashes, was forebodingly dark and somewhat dry.
Chili Lili's delves into sandwiches, too, served with waffle-cut fries or red cabbage slaw that's a little spicy, a little sweet from mango and crunchy with sunflower seeds. Nice, but sometimes I just wished for the simple tang of classic, creamy slaw.
There's a chili dog, of course - a Usinger's frankfurter ($8) crowned with Cincinnati-style. The toasted bread holding it was no match for the chili.
A juicy, dense half-pound burger ($10; with aged cheddar, $11) of Wagyu beef on a firm, flavorful roll is a burger worth ordering. (The menu notes it's just like the burger at Lagniappe Brasserie in New Berlin; owner Andy Tenaglia knows Chili Lili owner Jay Schiek and helped developed the menu.)
This menu has wholesome intentions. The chicken is free-range; greens - as in a salad with berries and goat cheese ($11) - are organic.
And an award-winning state butter goes into desserts: the oversized chocolate chip cookie ($3); upside-down cake ($5) with sweet apples, when I had it; and flourless chocolate cake spiked with mild guajillo chili ($5), all served warm.
This restaurant may be based on the classic model of a chili parlor, but it's no greasy spoon.
August Weber Haus
W63-N678 Washington Ave., Cedarburg
(262) 618-4453
** 1/2 (good to very good)
Food: **
Service: ***
Ambience:** 1/2
Fare: Fondues, appetizers
Atmosphere: Cozy 19th-century home-turned-lounge
Hours: Dinner 5-9 p.m. Monday-Thursday, 5-10 p.m. Friday-Saturday; bar open until midnight
Prices: Entrées, $43-$49 for two to four
Parking: Behind restaurant, via driveway just north of building
Wheelchair access: To patio in summer. Step at entry; all dining tables are high-tops
Payment: MasterCard, Visa
Of special note: Wine bar and martini lounge; nonsmoking warm-weather patio; lunch menu in summer
Reservations: Recommended
Noise level: Can be loud
Chili Lili's Chili Bar
525 E. Menomonee St., at N. Jackson St.
(414) 897-0555
** 1/2 (good to very good)
Food: ** 1/2
Service: **
Ambience: ** 1/2
Fare: Cincinnati-style and five other chilis, sandwiches and salads
Atmosphere: Contemporary chili parlor and bar
Hours: 11 a.m.-10 p.m. Sunday-Thursday; 11 a.m.-11 p.m. Friday-Saturday
Prices: Main dishes, $8-$12
Parking: On street
Wheelchair access: Yes, entry and restrooms
Payment: MasterCard, Visa, Discover
Of special note: Children's menu and changing table; vegetarian and vegan options; party room available for up to 50; gluten-free garlic bread
Reservations: Accepted for groups of seven or more
Noise level: Comfortable
Carol Deptolla dines anonymously with food and drink paid for by the Journal Sentinel.
Contact Carol Deptolla at (414) 224-2841 or at firstname.lastname@example.com.
Carol Deptolla Archive
- Jul 29, 2016 | Plates with style in downtown West Bend
- Jul 29, 2016 | Move to West Bend suits Tochi
- Jul 22, 2016 | Crawdaddy's reopening has its ups and downs
- Jul 22, 2016 | Big Eazy finding home for New Orleans cuisine on King Drive
- Jun 24, 2016 | At Blue Star Cafe, Somali entrees, appetizers and hefty sandwiches
- Jun 17, 2016 | Kim's Thai opens new spot with same delicious stuffed chicken wings
- Jun 10, 2016 | Summer brings new outdoor patios to Milwaukee-area eateries
- May 27, 2016 | Urban Beets marches to veggie beat
- May 20, 2016 | Places for great barbecue in Milwaukee
- May 13, 2016 | Regional Mexican dishes at Restaurante Juquilita
- Apr 29, 2016 | New old Karl Ratzsch is fresh but familiar
- Apr 22, 2016 | Si, C-viche in Bay View
- Apr 8, 2016 | Easy Tyger: A view of the globe from Brady St.
- Apr 1, 2016 | Good bites to go with that coffee
- Mar 25, 2016 | Irie Zulu's menus let diners explore Africa, Jamaica
- Mar 18, 2016 | Asian Fusion brings a world of traditional flavors to east side
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text:
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- False Memory Syndrome and the Inquisition
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text:
Fernand & Sergio - WorldOfMen
Models: Fernand Dutch and Sergio Moreno
Studio: World of Men
I meet the boys in the most famous canal of all Amsterdam (the one with the nice girls in the window) and after a few bad looks from the girls and their bodyguards we just made our way back to the flat. The boys don't waste any time and get busy as soon as we get in. They kiss passionately but at the same time Sergio's hands find their way to Fernand's white smooth ass. His hole is so welcoming that Sergio bends him over to rim and finger him. Fernand turns around and sucks Sergio's thick cut cock before presenting his own cock for servicing. Sergio sucks him back but soon turns his attention back to Fernand's hole. The boys move upstairs to the bed and after a bit more sucking and ass play Sergio places himself behind a four legged Fernands and pushes his hard cock balls deep inside him. He fucks him hard and deep on all fours then they stand up and Fernand is fucked against the wall until Sergio makes him come pushing 4 fingers up his mate's ass. Fernand narrowly misses me then they switch places and Sergio unloads on Fernand's face and chest.


text:
iHerb 顾客评论
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Great product
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Made me feel wonderful
Love this product!
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I used these and noticed a huge difference. Over 4 months, I lost 18cm off my waist and 15 cm off my hips.
Green Tea Fat Metabolizer
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I believe that green tea assists digestive processes. And anything that might prevent fat from storing in the body is helpful.
too smelly
5026863904491809081发表于 May 16, 2013
The rancid smell is unbearable, too bad that it could not be returned, so I go for the Now Foods Thermo Green Tea 700mg.
Havent tried yet
4707197647836606895发表于 Jul 01, 2013
Havent tried yet . I hope it will work.
产品 1-5,共 5 个产品


text:
Car crashes into gift store, leaves sticky, runny messBy Patrick McArdle
STAFF WRITER | December 15,2013MARLBORO A gift shop sustained extensive damage when a car crashed into it Friday evening.
Vermont State Police said Frederick Bump, 67, of Brattleboro was driving a 2013 Subaru XV east on Route 9 around 9:45 p.m. when he lost control in the slush.
Bump crashed into the exterior wall of the Hogback Mountain Gift Shop at an angle, according to Trooper Ryan Wood. The car knocked down a 15-foot section of the stores exterior wall and destroyed a large amount of merchandise inside the store.
Bump was not injured but the car was destroyed, Wood said.
Store owner Ed Metcalfe said Saturday he was dealing with a sticky, runny mess of jams, wines, maple syrup and pancake mix.
The most damage was done to a wall where Vermont wines were displayed, Metcalfe said, along with 200 to 300 jars of jams and jellies. The crash knocked those items into a display of maple syrup, he said.
Metcalfe said the crash didnt close the store, but he might close on Sunday because of the expected storm.
The area of Route 9 where the gift shop is located has a bad curve so vehicle crashes arent unusual, Metcalfe said. He said his building has been hit about three times since he became involved with the business in 2002.
Because the accident happened at night, when the store was closed, no employees or customers were hurt, Metcalfe said.MORE IN This Just InPolice: Drunk driver crashes
HARTFORD A Hartland man was cited for drunk driving after... Full StoryBENNINGTON A local man was charged with two felony counts of forgery on Monday in Bennington... Full StoryBENNINGTON Two Pownal residents were arraigned on a felony charge of cultivating marijuana on... Full Story
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text:
Western Australia
A CURTIN University lecturer has been charged for allegedly seeking and receiving a $1500 bribe to alter the exam marks of a student.
The lecturer, a 53-year-old man from Connolly, will appear in court on following a Corruption and Crime Commission investigation into his conduct.
He is alleged to have offered to increase the marks of a student, who he claimed had failed an exam, for $100 per mark, amounting to a $1500 bribe.
Curtin University reported the allegation to the CCC.
The Commission's investigations manager Trevor Wynn said they suspect other students, some from overseas, may have also been approached to pay bribes for higher marks.
He said the CCC would like to hear on a confidential basis from any students who may have been approached by the lecturer.
The Commission will work with the university over the coming weeks to ensure no student has been disadvantaged.
The lecturer will appear in Perth Magistrates Court on November 29.


text: I searched before posting, but none of those solutions worked, and I'm trying to avoid deleting my entire library, and moving it all back into iTunes. Anyway, my external HD started dying on me. I could tell when I would freeze up, and fail to show all the folders I knew were on it. Using disaster recovery software, I was able to save all my files (and not have to re-rip everything). What i've tried: "Consolidating iTunes library" doesn't work because the external locks up when it's accessed, the disaster recovery software was the only thing that was able to do anything with it. I tried manually editing the "iTunes Library" and "iTunes Music Library" XML file in the iTunes folder, but that didn't work either. All I did was "Replace all" for "H:/itunes/music" to "J:/music/itunes/music" but when I opened iTunes I had exclamations points on all my songs. Is there any other easy way to tell iTunes ALL my music is in a new location? Thanks.


text:
Offices To Go Executive Leather Chair w/ Polished Aluminum
Free Shipping!
This product typically ships within 2-3 business days more details
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This item includes free shipping in the contiguous United States. Most orders will ship via UPS or FedEx Ground. Orders for large items or multiple item orders will ship via freight carriers such as Roadway, Road Runner, and FedEx Freight.
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When the items are delivered it is the customer's responsibility to inspect all cartons and items to make sure that there is no visible damage or missing packages. If there is damage or missing packages, make sure to note it on the delivery receipt or bill of lading. If this is not noted on the bill of lading the cost to replace damaged items will be the customers responsiblity. Make sure to retain a copy for your records as well. Please contact us immediately at 866-733-0698 so that we can arrange for replacements to be sent out.
Shipping Glossary
- Loading dock - This service is available to companies that have a loading dock at their facility. This service is free!
- Curbside - The items will be brought to the closest curb and the customer will be responsible for unloading the items from the back of the freight truck. This service is free!
- Lift gate - The driver will unload the items from the back of the truck for you but you will be responsible for bringing them into the location.
- Residential freight - This service is available to residential (home) deliveries. The items will be delivered by a freight truck. The items will be brought down from the back of the truck for you but you will be responsible for bringing the items into the residence.
- Inside delivery - Will only be dropped off inside the threshold of the front door.
- Description
- Shipping Info
- Reviews
Customers Also Viewed
Business leaders are often required to spend many hours behind their desks every day, making it imperative to find comfortable, supportive executive office chairs. Our Offices To Go Executive Leather Office Chair with Polished Aluminum Base is the ideal blend of function and style with its gorgeous black leather, aluminum accents, and adjustable seat height and tilt tension. This executive office chair comes with a limited lifetime warranty, making it a sensible choice for any business professional in need of stylish comfort.
OTG-11633 Specifications
Overall Dimensions: 31"D x 26"W x 43"H
Seat Dimensions: 21"D x 22.5"W x 16-20"H
Back Dimensions: 22"W x 25"H
Arm Height: 10"H
Rated for 250 lbs
Ready to Assemble
Offices To Go Leather Executive Office Chair Features
- Leather Executive Chair
- Attractive black leather upholstery with mock leather trim
- Fixed height molded arms with padded armrests
- Single position tilt lock with tilt tension adjustment
- Pneumatic seat height adjustment
- Polished aluminum arms with upholstered arm caps
- Polished aluminum base with scuff tips and twin wheel carpet casters
Warranty and Shipping
Offices To Go Warranty
Limited Lifetime Warranty (more details here)
Shipping Information
This item includes free shipping in the contiguous United States.(more details here)


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