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BMW X5 M Repair and Maintenance
A guide to problems, costs, maintenance and repair for your BMW X5 M
Never overpay. Check prices with our estimator
BMW X5 M QuestionsBuying this used car /low miles-diagnostic test at dealership says it has a vac (1 answer)
pump leaking oil (Low miles like 26K ) Should I proceed if I replace the pump ? .
It was at park and the car roll itself and the break became unexpected acceleration. Not sure why/ how cause this problem and BMW wasn't able to find out the truth. Just wanted to warm people have X5 watch out the in this situation.
BMW X5 M RecallsFront Universal Joint In Drive Train Fails
The front drive shaft universal joint may corrode and fail. Dealers will replace the front drive shaft free of charge to resolve the concern.
All modern vehicles use some type of power assist for the braking system. The 8 cylinder models being recalled use a vacuum pump, connected to the power booster by a vacuum hose, to provide the necessary assist. The vacuum pump may leak a small amount of lubricating oil into the vacuum hose and this contamination could result in a loss of power assist, leading to increased stopping distances. Dealers will correct this concern by replacing the brake vacuum line with an improved version.
Certain 2012 X5 models equipped with a diesel engine, and a number of 2013 X5 and X6 models, may develop a power steering fluid leak from the steering gear. This leak is due to a machining error on the steering gear. Leaking power steering fluid can spray onto hot exhaust parts, increasing the risk of an engine compartment fire. Dealers will inspect and replace the steering gear as necessary on affected vehicles.


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Student art exhibition opens at Stifel
Oglebay Institute continues to encourage and showcase student artwork by once again hosting the Regional Student Art Exhibition at the Stifel Fine Arts Center in Wheeling.
For more than 20 years, this popular annual exhibition has showcased artistic achievements of high school students and provided a foundation for continued creativity. The exhibit features art in all media and can be viewed by the public free of charge from now through March 11.
"Each year I continue to be impressed by the caliber of work submitted," director of exhibitions Brad Johnson, said. " There are many talented art students in our region."
Students from nine area schools Monroe Central, Union Local, Avella, Wheeling Park, Wheeling Central, Linsly, Lyceum Academy, St. Clairsville and Georgette's School of Fine Art- submitted a total of 153 entries. Twelve winners were chosen in four categories: drawing, painting, photography and 3-D/multi-media. A Best of Show Award was also given, and four works received honorable mentions. Artist and art instructor Mary Ann Snyder juried the show.
Christine Gompers of Wheeling Central won Best of Show for her work "The William Express." First place in drawing went to Polly Clarchick of Avella for "Contemplating The Conversation." First place in painting went to Ashley Gordon of St.Clairsville for her work "Chef in the Corner." Chelsey Wamsley of St. Clairsville High School received first place in photography for "Rusted Bottle Cap." First place in 3-D/multi-media went to Grace Mull of Linsly for "Iron Dragon."
Other winners are: Drawing, second place, Jenna Britton, Union Local; third place, Union Local student Alexus Davis. Painting: second place, Bree Sawyers, Union Local; third place, Jenna Britton, Union Local. Photography: second place, Maddie Ware, Avella; third place went to Zach Gray of Avella .3-D/multi-media: second place, Justin Carlisle, Avella; third place, Grace Mull of Linsly.
Honorable mentions include: Justin Holt, Union Local; Bree Sawyers, Union Local; Ashley Saffell, Avella, Dustin Kubacka, Avella.
All winning artists received ribbons. Prize money was awarded to the Best of Show and the top three artists in each category. Some students were also awarded art scholarships to West Virginia University.
Oglebay Institute President Kathleen McDermott presented monetary awards to winning artists at the opening reception January 13. She congratulated the students for their dedication and talent; thanked the teachers for continuing to advocate the arts; and commended the parents for nurturing and encouraging creativity in their children.
Sponsored by United Bank of West Virginia, this exhibition can be viewed free of charge through March 11 in the Hart Galleries of the Stifel Fine Arts Center, located at 1330 National Road in Wheeling.
Part of the Helen B. Gaither Exhibition Season, this program was also made possible through the generous support of the members of the Institute as well as with financial assistance from the West Virginia Commission of the Arts and the National Endowment for the Arts.
For more information, call 304.242.7700 or visit on the web at www.oionline.com

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This Light Bar Raises the "Bar" on Safety Standards Emergency Light Wand At a full 21 inches of glowing force, this lengthy, narrow light bar from ActiveForever has enough power to be visible by the naked human eye from up to a mile away. The Light Wand emergency lights are an important part of an emergency preparedness plan and is an essential tool for when you become stranded at night, or in an otherwise dark place. Even if you are someone who tends to live life on the edge and you are traditionally not troubled or concerned with being prepared for life's various situations, the Light Wand is a worthy investment simply because it's ratio of effectiveness to simple to operate works so heavily in its favor. Even if you are the type of person who doesn't mind being stranded with naught but your own cunning to defend you, it's nice to be able to see a few things. You have to admit. Plus, if the electricity in your house, apartment, duplex, condominium, castle, igloo, View more
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"The definition of being a modern person is to examine yourself, to reflect on yourself and to be a self-knowledgeable person."
"The paradox is that there has never been so much control of images by governments and corporations- control of images, control of our landscape, of this landscape that affects our lives. What we see is what makes us. What kinds of thoughts do we have, based on this landscape that surrounds us, this landscape that is so much under control?"
- Alfredo Jaar


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Live Donald Driver ceremony to pre-empt local programming
Although the supposed link between Ryan Braun and a Miami PED clinic signals the start of baseball season, football has one more ace up its sleeve - the Donald Driver retirement ceremony.
WTMJ-TV (Channel 4), WISN-TV (Channel 12) and WITI-TV (Channel 6) expect to pre-empt local programing for live coverage of the event at Lambeau Field in Green Bay at 11 a.m. Wednesday. »Read Full Blog Post
Matchbox Twenty keeps the customer satisfied
Rob Thomas made a promise early in Matchbox Twenty's Milwaukee set Saturday, to give the audience "the best tonight you could possibly have."
But for a significant portion of the two-hour set at the Riverside Theater, Thomas, his three Matchbox bandmates and two touring musicians didn't appear to live in the moment as much as in the past, specifically back in the late '90s and early aughts when the band's barely impactful but catchy pop rock were a resounding soundtrack of the era. »Read Full Article(6)
Lottery winnings bring little joy to play's characters - or its audience
For all its obvious faults, goulash communism - featuring modest economic reforms and more liberal social policies - seemingly positioned Hungary for a more successful and humane transition from Stalinism.
Guess again. »Read Full Article
MSO, Solzhenitsyn present stirring sounds of Russia
Russian classical music sounds Russian.
Writers write about it, scholars think about it, but no one has really managed to explain why the music written over the 200-or-so year history of Russian classical music sounds so absolutely Russian. »Read Full Article
Tift Merritt blends best of country styles in Shank Hall show
The direct distance from Milwaukee to Nashville is about 480 miles. The distance from Milwaukee to Bakersfield is about 1,735 miles.
Friday night at Shank Hall, Tift Merritt brought all three cities a little closer together. »Read Full Article


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4 Bedroom Detached House For Sale
John Brown Close, Horncastle, Lincolnshire, LN9
In brief the downstairs accommodation comprises lounge leading through to the dining room and conservatory, plus further doors from the entrance hall to the breakfast kitchen and utility with WC. The first floor offers four bedrooms with en-suite to the master, plus...
4 Bedroom Detached House For Sale
Bells Yard, Lincs, LN9
Last remaining brand new property with stunning views to the front The Lindsey is a large four bedroom property, enjoying views over the lake, generous parking and garage, walking distance of town amenities. Part-exchange considered, Help-to-buy also available.
3 Bedroom Detached House For Sale
Madely Close, Horncastle, LN9
In brief, the downstairs accommodation comprises a dual-aspect lounge, modern fitted dining kitchen, utility with WC and conservatory leading out to the attractive rear garden. The floor benefits from three double bedrooms with en-suite to the master, plus bathroom...
3 Bedroom Detached House For Sale
Wesley Way, Horncastle, Lincolnshire, LN9
The spacious accommodation offers a range of modern amenities including downstairs cloakroom and utility with door through to garage, en-suite shower room to the master bedroom, double glazing and gas-fired central heating. Outside the property benefits from generous...
3 Bedroom Semi Detached House For Sale
Southfield Place, Horncastle, Lincolnshire, LN9
This bay fronted property comprises a generous dining kitchen, lounge, downstairs shower room and WC/utility, with the first floor comprising two further bedrooms plus a further bathroom (or possible bedroom three). Externally there is off-road parking to the front and
2 Bedroom Semi Detached House For Sale
College Close, Horncastle, LN9
This modernised property has the benefit of extensive parking with a detached garage and attractive garden to the rear. The ground floor accommodation briefly comprises lounge, dining room with archway to the kitchen, plus two bedrooms and bathroom to the first floor. T
1 Bedroom End of Terrace House For Sale
West Street, Horncastle, Lincolnshire, LN9
In brief, the accommodation comprises an initial front reception room leading through to the kitchen. The first floor offers lounge and bathroom with first bedroom located on the second floor. The property also has the benefit of gas central heating.
2 Bedroom Terraced House For Sale
Prospect Street, Horncastle, Lincolnshire, LN9
In brief the ground floor accommodation comprises lounge, breakfast kitchen and bathroom with two bedrooms to the first floor. The accommodation has been complimented by double glazing and gas central heating and the property further benefits from a paved garden to the
2 Bedroom Terraced House For Sale
Paradise Row, Horncastle, Lincolnshire, LN9
This two bedroom property benefits from a modern fitted kitchen and bathroom, UPVC double glazing and gas-fired central heating plus a garden laid to lawn and two brick built stores. In the agent's opinion the property could be ideal for a first-time buyer or investor,
2 Bedroom Terraced House For Sale
North Street, Horncastle, LN9
This two storey leasehold apartment benefits from excellent room sizes and offers accommodation comprising lounge, kitchen and bathroom to the first floor, with the second floor providing two generous double bedrooms and a cloakroom/WC. In the agents opinion the...
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Acute Myeloid Leukemia With IDH1 or IDH2 MutationFrequency and Clinicopathologic Features
Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are reported in acute myeloid leukemia (AML). We studied the frequency and the clinicopathologic features of IDH1 and IDH2 mutations in AML. Mutations in IDH1 (IDH1R132 ) and IDH2 (IDH2R172 ) were assessed by Sanger sequencing in 199 AML cases. Point mutations in IDH1R132 were detected in 12 (6.0%) of 199 cases and in IDH2R172 in 4 (2.0%) of 196 cases. Of the 16 mutated cases, 15 (94%) were cytogenetically normal, for an overall frequency in this group of 11.8%. IDH1R132 and IDH2R172 mutations were mutually exclusive. Concurrent mutations in NPM1, FLT3, CEBPA, and NRAS were detected only in AML with the IDH1R132 mutation. The clinical and laboratory variables of patients with AML with IDH mutations showed no significant differences compared with patients with wild-type IDH. We conclude that IDH1R132 and IDH2R172 mutations occur most often in cytogenetically normal AML cases with an overall frequency of approximately 11.8%.
- Acute myeloid leukemia
- Isocitrate dehydrogenase
- Mutation
Identification of somatically acquired gene mutations has provided critical insights into the pathogenesis of acute myeloid leukemia (AML).1 Gene mutations in AML provide useful markers for diagnosis and for monitoring response to therapy and also provide information useful in assessing prognosis and making therapeutic decisions.2–6 The most recent World Health Organization (WHO) classification of myeloid neoplasms acknowledges the clinical significance of gene mutations in AML and has proposed separate entities for AML with mutations in NPM1 and CEBPA.7 It is interesting that mutations in AML are detected commonly in cytogenetically normal (CN) cases, which account for 40% to 50% of all AMLs.1,8 Currently, no known mutations are identified in about 20% to 30% of CN AML cases, suggesting the possibility that more mutations likely exist.
Recently, the entire genome of a patient with CN AML was sequenced, and a total of 64 somatic mutations, 12 within coding sequences of genes and 52 in conserved or regulatory regions, were identified.9 In particular, a novel mutation was detected in isocitrate dehydrogenase 1 (IDH1), a metabolic gene frequently mutated in gliomas.10–12 The mutation occurred consistently at an evolutionary conserved arginine residue at codon 132 (R132) within the substrate binding site of the enzyme and was strongly associated with normal cytogenetic status. A limited number of studies examining the frequency of the IDH1 mutation in AML were performed subsequently.13–16 In addition to IDH1R132 , mutations in codon 172 of IDH2 (IDH2R172 ), a mitochondrial isoform of IDH1, have been documented in AML.14,17
Published studies have focused on examining the frequency and correlation with mutational status and clinical outcome. A very limited amount of information is available on the histomorphologic features and immunophenotypic profiles associated with IDH1R132 and IDH2R172 mutations in AML. Only 1 study, involving a Chinese population, reported clinical and biologic features of AML with the IDH1R132 mutation.16 There are no such reports available for the Western population or for AML with the IDH2R172 mutation.
We report the frequency of IDH1R132 and IDH2R172 mutations in 199 AML cases with clinical, histologic, and immunologic characterization of the mutated cases. We also performed a meta-analysis of available studies that have assessed AML cases for IDH1R132 mutations.
Materials and Methods
Study Group
DNA was extracted from diagnostic bone marrow aspirate samples of AML with 20% or more blasts using methods described previously.18 All samples had been sent to the clinical Molecular Diagnostics Laboratory, The University of Texas M.D. Anderson Cancer Center, Houston, at the time of diagnosis. Residual DNA was used under an approved institutional review board protocol. Cases of AML with favorable-risk cytogenetics were excluded from analysis based on data from an earlier study that showed absence of IDH1 mutations in this group.9 Pertinent laboratory information was obtained from the laboratory information system. The patient characteristics are listed in Table 1 and Table 2.
IDH1 and IDH2 Mutation Detection
Exon 4 mutations in codon R132 of IDH1 and codon R172 of IDH2 were detected by using polymerase chain reaction (PCR) amplification followed by Sanger sequencing. Previously described PCR primers were modified with the addition of M13 sequence.19 The PCR primers used were forward, 5′- TGTAAAACGACGGCCAGTC GGTCTTCAGAGAAGCCATT-3′ and reverse, 5′-CA GGAAACAGCTATGACCGCAAAATCACATTATT GCCAAC-3′ for IDH1R132 and forward, 5′-TGTAAAA CGACGGCCAGTAGCCCATCATCTGCAAAAAC-3′ and reverse, 5′-CAGGAAACAGCT ATGACCCTAGGCG AGGAGCTCCAGT-3′ for IDH2R172 . All primers were purchased from Integrated DNA Technologies, Coralville, IA.
For IDH1R132 and IDH2R172 , 2 μL of patient DNA (100 ng/μL) was added to 48 μL of PCR master mix that consisted of 31.7 μL of molecular grade water, 5 mL of 10× PCR buffer II (Applied Biosystems, Carlsbad, CA), 4 μL of 25 mmol/L magnesium chloride, 10 mmol/L deoxynucleoside triphosphate (dNTP) mix, 1 μL each of M13-tagged forward and reverse primers (10 μmol/L), and 0.3 μL of Amplitaq Gold (5 U/μL; Applied Biosystems). PCR conditions for IDH1R132 and IDH2R172 included initial denaturing at 95°C for 10 minutes; 40 cycles of 95°C for 30 seconds, 60°C for 30 seconds, and 72°C for 30 seconds; and final extension at 72°C for 7 minutes.
Post-PCR purification of the products was performed using QIAquick kit (Qiagen, Valencia, CA). PCR products were analyzed on a 2% agarose gel (115 V for 30–40 minutes) using 8 μL of PCR product and 2 μL of 1× gel-loading dye. Sanger sequencing of IDH1R132 and IDH2R172 amplicons was performed using M13-tagged primers in a 20-μL final volume that contained 4 μL of PCR product, 6.8 μL of water, 2 μL of 5× sequencing buffer, 3.2 μL of M13 forward or reverse primer (1 μmol/L), and 4 μL of BigDye v1.1 (Applied Biosystems). Sanger sequencing was performed using M13 forward, 5′-TGTAAAACGACGGCCAGT-3′, and M13 reverse, 5′-CAGGAAACAGCTATGACC-3′, primers.
Sequencing conditions included initial denaturing at 96°C for 1 minute and 25 cycles of 96°C for 10 seconds, 50°C for 5 seconds, and 60°C for 4 seconds. Sequencing products were purified using the DyeEx 96 Spin Kit (Qiagen) and analyzed by capillary gel electrophoresis on the 3130 genetic analyzer (Applied Biosystems).
NPM1 Mutation Detection
Mutations in coding regions of exon 12 of NPM1 were detected using PCR amplification of a 168-base-pair segment followed by capillary gel electrophoresis. PCR primers included forward, 5′-FAM-GATGTCTATGAAGTGTTGTGGT-TCC-3′ and reverse, 5′- GGACAGCCAGATCAACTG-3′. PCR was performed in a 50-μL reaction volume that contained 2 μL of patient DNA (100 ng/μL), 5 μL of 10× ThermoPol Buffer (New England BioLabs, Ipswich, MA) with magnesium sulfate, 5 μL of 10 mmol/L dNTP, 1 μL of NPM1 forward primer (10 μmol/L), 1 μL of NPM1 reverse primer (10 μmol/L), 35.2 μL of water, and 0.75 μL of Vent DNA polymerase (New England Biolabs) (2 U/μL). PCR conditions included initial denaturing at 95°C for 10 minutes, 40 cycles of 95°C for 30 seconds, 55°C for 30 seconds, and 72°C for 30 seconds, and final extension at 72°C for 7 minutes. PCR products were analyzed by capillary electrophoresis on a 3100 or 3130 genetic analyzer (Applied Biosystems).
RAS Mutation Detection
Mutations in codons 12, 13, and 61 of KRAS were detected by using pyrosequencing as described earlier.18 Mutations in codons 12, 13, and 61 of NRAS were detected with the same protocol but using the following primers: codons 12 and 13, forward, 5′-GTTCTTGCTGGTGTGAAATGA-3′; reverse, 5′-BIOTIN-CTCTATGGTGGGATCATATTC-3′; and sequencing, 5′-CAAACTGGTGGTGGTTGGAGCA-3′; and codon 61, forward, 5′-GGACATACTGGATACAGCT-3′; reverse, 5′-BIOTIN-CTGTAGAGGTTAATATCCGCA-3′; and sequencing, 5′-GGACATACTGGATACAGCT-3′.
Detection of KIT, FLT3-ITD, FLT3-D835, CEBPA, and TP53 Mutations
Mutation analysis for KIT, FLT3-ITD, FLT3-D835, CEBPA, and TP53 mutations was performed using Sanger sequencing as described previously.20–23 For CEBPA and TP53, an M13 sequence was added to the previously described PCR primers for Sanger sequencing. M13-tagged primers were used for Sanger sequencing.
Morphologic, Immunophenotypic, and Cytogenetic Analysis
Bone marrow aspirate smears were stained with Wright-Giemsa, and aspirate clot and biopsy specimens were stained with H&E. Flow cytometric immunophenotypic analysis was performed using 4-color staining, and conventional G-banded karyotyping was performed as described previously.24
IDH1R132 and IDH2R172 Mutations in AML
A total of 199 AML cases were tested for IDH1R132 mutation, and 196 cases were tested for IDH2R172 mutation (Tables 1 and 2). The IDH1R132 mutation was detected in 12 cases (6.0%), and the IDH2R172 mutation was detected in 4 (2.0%) of 196 cases Figure 1. No mutated cases had both IDH1 and IDH2 mutations, suggesting that these mutations are mutually exclusive.
Cytogenetic Features of IDH-Mutated AML Cases
The AMLs tested included 127 (63.8%) with normal and 72 (36.2%) with abnormal cytogenetics. Subdivided by cytogenetic risk group, 166 cases (83.4%) were intermediate risk and 33 (16.6%) were poor risk. Of 12 AML cases with an IDH1 mutation, 11 (92%) had normal cytogenetics and all 12 (100%) were in the intermediate-risk cytogenetic group. The association between IDH1 mutation and normal cytogenetics approached statistical significance (P = .059; Fisher exact test). All 4 cases with an IDH2 mutation had normal cytogenetics and belonged to the intermediate-risk group. Of the 16 mutated cases (12 IDH1 and 4 IDH2), 15 (94%) were cytogenetically normal, for an overall frequency in this group of 11.8% (15/127).
Molecular Features of IDH-Mutated AML Cases
The 12 AMLs with IDH1R132 mutations were equally distributed between R132H and R132C substitutions Table 3. All IDH2R172 mutations resulted in R172K substitutions (Table 3). IDH1R132 -mutated cases showed a higher frequency of concurrent NPM1 mutation compared with wild-type cases (5/11 [45%] vs 13/54 [24%]), which did not achieve statistical significance (P = .161; Fisher exact test). Additional gene mutations were identified in IDH1-mutated cases, including NPM1, FLT3-ITD, CEBPA, NRAS, KIT, and FLT3-D835 (Table 1). Of 11 IDH1-mutated cases, 8 (73%) met the criteria for the high-risk molecular group. There was no significant association of the IDH1R132 mutation with FLT3-ITD, FLT3-D835, CEBPA, NRAS, KRAS, or KIT mutations or a high-risk molecular profile (Tables 1 and 3).1,25 None of the 4 IDH2R172 -mutated cases showed a concurrent mutation in NPM1, FLT3-ITD, FLT3-D835, CEBPA, NRAS, KRAS, KIT, or IDH1 (Tables 2 and 3). All 4 IDH2R172 -mutated AMLs met the criteria for the high-risk molecular group based on the absence of the NPM1 mutation.
TP53 Mutations in AML Cases With the IDH1R132 Mutation
In glioma, non-R132H mutations of IDH1 are associated with a higher frequency of TP53 mutations and a distinct gene expression profile compared with the R132H mutations. We therefore tested 11 available IDH1R132 -mutant AML cases for TP53 mutations. We detected a P72R polymorphism, known to predispose to a variety of human cancers, in 4 of 5 R132C cases and 5 of 6 R132H cases. We did not find any significant difference in the frequency of TP53 mutations in R132C and R132H subgroups, as each subgroup had only 1 case with TP53 mutation.
Morphologic and Immunophenotypic Features of AML With IDH Mutations
For AMLs with the IDH1R132 mutation, the mean blast count was 55% (range, 22%–88%). Using the WHO classification, the mutated cases were classified as AML, not otherwise specified (NOS; n = 10) or AML with myelodysplasia-related changes (n = 2). The AML, NOS group was further classified as AML without maturation (French-American-British classification [FAB] M1), AML with maturation (FAB M2), and acute monocytic leukemia (FAB M5). Auer rods were detected in 5 (50%) of 10 cases. Dysplastic features in 1 or more hematopoietic lineages were evident in 10 (83%) of 12 AML cases with the IDH1R132 mutation and 3 (75%) of 4 AMLs with the IDH2 mutation Table 4. Bone marrow cellularity ranged from 25% to 100% (mean, 71%).
For AMLs with IDH2R172 mutations, the mean blast count was 53% (range, 20%–98%). These 4 mutated cases were classified as AML without maturation (n = 3) and AML with maturation (n = 1). IDH2-mutated cases were significantly more often classified as AML without maturation compared with IDH2 wild-type AML cases (3/4 [75%] vs 27/192 [14.1%]; P < .01; Fisher exact test). Auer rods were detected in 3 (75%) of 4 cases. Of 4 AML cases with the IDH2 mutation, 3 (75%) showed dysplastic features in 1 or more hematopoietic lineages (Table 4). Bone marrow cellularity ranged from 60% to 80% (mean, 70%).
Flow cytometric Immunophenotypes of AML with IDH1R132 and IDH2R172 mutations are similar and are listed in Table 5. Overall AMLs with the IDH1R132 or IDH2R172 mutation showed a myeloid immunophenotype: CD117+, HLA-DR+/– (more cases positive than negative), CD34+/–, CD38+, CD13+, CD33+, and myeloperoxidase+/–. CD64 was present in AML M5, consistent with monocytic differentiation.
Clinical Features of IDH-Mutated AML Cases
For the 12 IDH1-mutated AMLs, the mean age was 55 years (range, 37–77 years), and the male/female ratio was 1:3. The mean WBC count was 15,000/μL (15.0 × 109/L). For the 4 IDH2-mutated cases, the mean age was 51 years (range, 22–76 years), and the male/female ratio was 1:3. The mean WBC count was 4,000/μL (4.0 × 109/L). There was no significant difference in age, sex, WBC count, platelet count, hemoglobin level, bone marrow blast count and cellularity, dysplastic features, or morphologic classification between the IDH1- and IDH2-mutated AML cases (Table 1).
These clinical variables in the IDH1- and IDH2-mutated AML cases were also compared with wild-type AMLs. IDH2R172 -mutant AMLs were also significantly associated with a lower WBC count compared with wild-type AMLs (4,300/μL vs 20,000/μL [4.3 vs 20.0 × 109/L]; P < .001; Student t test). There was no significant difference in age, sex, and blast count between IDH1-mutated and unmutated AML cases or between IDH2R172 -mutated and unmutated cases (Table 2).
Meta-analysis of AMLs With IDH1R132 Mutation
We performed a meta-analysis of all available studies that assessed for IDH mutations in AML cases. To date, virtually all studies have focused on IDH1 mutations in AML, with a total of 1,787 AMLs reported, with 146 cases (8.2%) being mutated Table 6. Because the IDH1R132 mutation is predominantly restricted to CN AML, inclusion of AML cases with abnormal karyotypes in earlier studies most likely underrepresents the true frequency of IDH1 mutations in CN AML. We extracted the fraction of CN AMLs with the IDH1R132 mutation from the studies reported. Of 1,152 CN AMLs tested, 129 (11.2%) showed the IDH1R132 mutation compared with 17 (4.7%) of 360 AMLs with an abnormal karyotype. Review of cytogenetic studies showed that all 66 IDH1-mutated AML cases were limited to the intermediate-risk category. IDH1R132 mutations resulted in a higher R132H substitution (73/146 [50.0%]) than R132C substitution (45/143 [31.5%]).
Analysis of available test results for coexisting mutations showed NPM1 to be the most common concurrent mutation, found in 87 (60.4%) of 144, followed by FLT3-ITD (37/146 [25.3%]) and CEBPA (14/155 [9.0%]). None of the 60 AMLs with an IDH1R132 mutation showed a concurrent IDH2 mutation. The number of AML cases assessed for the IDH2 mutation was too few to perform a similar meta-analysis.
IDH1 and IDH2, nicotinamide adenine dinucleotide phosphate+-dependent isocitrate dehydrogenases, catalyze the oxidative carboxylation of isocitrate to α-ketoglutarate. IDH1 has a key role in the production of the cytosolic reduced form of nicotinamide adenine dinucleotide phosphate necessary for the regeneration of reduced glutathione, a main antioxidant in mammalian cells.26 Recurring mutations in IDH1 and IDH2 occur at a very high frequency in many different types of glioma, especially secondary glioblastoma.12,27
IDH mutations in gliomas are always reported at the same arginine residues, R132 in IDH1 and R172 in IDH2, that are responsible for hydrophilic interactions with isocitrate.28 Initial analyses showed that IDH mutations were restricted primarily to gliomas, with rare cases of prostate cancer and B-lymphoblastic leukemia showing IDH mutations.12,29,30
Recently, Mardis and colleagues9 sequenced the entire genome of a cytogenetically normal case of AML and detected a novel IDH1R132 mutation. They subsequently screened 187 AML cases and showed a heterozygous IDH1R132 mutation in 15 cases (8.0%). Sixteen (original case plus 15 additional cases) IDH1R132 -mutated cases had available cytogenetic data, and 13 (81%) were CN AML. In addition, all 16 IDH1-mutated AMLs had intermediate-risk cytogenetics. These findings were in contrast with previous studies that did not detect the IDH1R132 mutation in 145 AML cases.12,30 Differences in the cytogenetic findings in the study groups and sensitivities of the detection assays could underlie these discrepancies. For this reason, we chose to undertake this study reviewing our experience in approximately 200 cases of AML at our institution.
Based on the available data in the literature, we specifically studied AML cases with intermediate- or poor-risk cytogenetic findings.9 Our results show that the frequency of IDH1 mutations is lower in CN AML cases. We detected IDH1R132 mutations in 11 (8.7%) of 127 CN AMLs compared with the initial report of 16%.9 We showed that all AML cases with the IDH1 mutation have intermediate-risk cytogenetics. In addition, we identified IDH2R172 mutations in 4 (2.0%) of 196 AML cases, all of which were CN AML. In no case did we find both IDH1 and IDH2 mutations, strongly suggesting that IDH1R132 and IDH2R172 are mutually exclusive. Only 1 other study has assessed for both IDH1 and IDH2 mutations in a large group of CN AML cases. Marcucci and colleagues14 showed that IDH mutations occur in 33% of cases, with IDH1 in 14% and IDH2 in 19%. The explanation for the higher rate of IDH1 and particularly IDH2 mutations in CN AML cases in this study, compared with our own data, is explained in large part because Marcucci and colleagues14 assessed for IDH2 mutations involving the arginine residue at codon 140 (R140). More than 80% of the IDH2 mutations they detected were R140 mutations. We did not test for IDH2R140 mutations in our study because the significance of mutations at this codon is unknown. These mutations have not been shown to have prognostic significance in AML and are not seen in other human cancers. Other authors have suggested that further studies are needed to determine whether R140 substitutions represent a true pathogenic mutation or a polymorphism.14
Because IDH1R132 is mainly limited to CN AML, the frequency of the IDH1R132 mutation in AMLs is likely to vary from one study to the next, depending on the percentage of AML cases with abnormal karyotypes. For example, the IDH1R132 mutation was detected in 7% of CN AMLs but in only 4% of all AML cases in a study by Ho and colleagues.15 It is therefore important to account for the cytogenetic composition of the study group when interpreting the frequency of IDH1R132 in AML. We performed meta-analysis of our study and other available studies to obtain a more global view of IDH1 mutations in AML. A total of 146 AMLs with the IDH1R132 mutation have been reported. Most cases with the IDH1 mutation have been CN AMLs and restricted to the intermediate-risk cytogenetic group. The overall frequency of the IDH1R132 mutation in CN AML is 11.0% (141/1,279). The male/female ratio is 1:1.1.
Despite the recent interest in IDH mutations in AML, a limited amount of information is available on morphologic and immunophenotypic features. Morphologic classification using the FAB system is available for 82 cases. The most common morphologic types were M1 in 34 cases (41%) and M2 in 25 cases (30%). Very few cases have been classified using the 2008 WHO system. The classification of cases in our study closely matches what has been reported. The IDH1-mutated cases were classified as AML, NOS (n = 10) or AML with myelodysplasia-related changes (n = 2). It is interesting that the IDH2-mutated cases were all AML, NOS. In this category, 7 cases were AML without maturation (FAB M1), 5 cases were AML with maturation (FAB M2), and 3 cases were acute monocytic leukemia (FAB M5). The immunophenotype of most cases in our study was typical myeloid, with expression of CD13, CD33, and CD117 in most cases and expression of CD34 in 9 of 15 assessed. These findings are generally consistent with a recent report in a Chinese population by Chou and colleagues.16 However, Chou et al16 reported that monocytic differentiation (FAB M4) and expression of CD13, CD14, and HLA-DR are unusual in AML with the IDH mutation. Our experience differs because 3 cases showed monocytic differentiation (FAB M5), and most cases expressed CD13 and HLA-DR.
Our study is the first to report bone marrow aspirate and biopsy findings of AML with IDH mutations in some detail. It is interesting to note that more than 80% of AML cases with the IDH1 or IDH2 mutation showed varying degrees of dysplastic findings in erythroid, myeloid, and megakaryocytic lineages. IDH1 mutations are shown to be early events in the development of astrocytomas and oligodendrogliomas. It seems plausible that IDH1 mutations are also an early event in myeloid neoplasia. A recent article reported IDH1 mutations in early myelodysplastic syndrome (MDS) and in secondary AML arising from MDS or MDS/myeloproliferative neoplasms (MPNs).31 In our study, 1 patient with AML with an IDH1R132 mutation had a history of MDS (case 12, Tables 3, 4, and 5). In 2 available studies on IDH1 mutations in MPN, one showed an IDH1 mutation with a coexisting JAK2 mutation, and the other failed to detect an IDH1 mutation in an MPN that transformed to leukemia.32,33 The involvement of IDH1 in myeloid neoplasms could be explained by a high requirement of glutamate, an essential amino acid that is converted to α-ketoglutarate and acts as a substrate for the mutant IDH1, as described subsequently, in myeloid cells.17,26,34 Indeed, acivicin, a glutamine antagonist, treatment decreased the growth and viability of a variety of leukemia cell lines.35
We detected equal distribution of R132H and R132C mutations in 12 AMLs with the IDH1R132 mutation. In the meta-analysis, R132H (73/146 [50.0%]) and R132C (45/146 [30.8%]) were the most frequent mutations detected. These findings suggest a different pattern of distribution of IDH1R132 mutations in AMLs than in gliomas, in which the R132H mutation constitutes about 90% of IDH1R132 mutations.12 In addition, we did not detect differences in TP53 mutation profiles of R132H and R132C AML cases, unlike those shown in gliomas.36 These findings suggest possible differences in the role of IDH1 mutations between glioma and AML. In fact, IDH1 mutations are associated with a good prognosis in glioma, whereas the limited amount of literature in AML suggests shorter disease-free survival in young patients with the IDH1-mutant/NPM1-mutant/FLT3-ITD–wild-type group.14,37
IDH1R132 mutations are frequently accompanied by NPM1, FLT3, CEBPA, RAS, and KIT mutations. We found NPM1 (5/11 [45%]) and FLT3-ITD (3/12 [25%]) mutations to be the 2 most frequent. Comparable frequencies of NPM1 (87/144 [60.4%]) and FLT3-ITD (29/146 [19.9%]) were detected in the meta-analysis. Unlike a recent study, we did not find statistically significant correlations of IDH1R132 and IDH2R172 mutations with NPM1-mutated and an FLT3-ITD–negative low-risk molecular profile.14 The frequent presence of coexisting mutations suggests that IDH1 mutations may act cooperatively in leukemogenesis. In contrast, no additional mutations were detected with IDH2R172 mutations in 4 cases. This finding is consistent with 13 cases in the only other available study.14
The details of a possible pathogenic role of IDH mutations are just beginning to emerge. Traditionally, up-regulation of a cancer-associated transcription factor, hypoxia-induced factor, has been considered to be a major pathogenic mechanism.26,38 More recently, accumulation of 2-hydroxyglutarate in the cells and the serum of patients with glioma and with AML with the IDH1 mutation has been shown.17,28,39,40 This could be used as a potential diagnostic test in the management of patients with IDH mutations.
All reported studies have used Sanger sequencing–based assays, which have a sensitivity of about 20%.9,13–17 Because IDH1 and IDH2 are heterozygous mutations, a minimum blast count of 40% and/or enrichment of myeloblasts will be needed for the Sanger sequencing–based detection of IDH mutations. In practice, however, we have detected IDH mutations in samples with a minimum blast count of 22%. Because there is an indication that the mutation is retained at relapse, highly sensitive laboratory assays will be needed for monitoring therapy response and early relapses.16,39 The involvement of specific codons allows the use of sensitive approaches such as high-resolution melt curve analysis and pyrosequencing-based assays, which are currently under development in our laboratory.
IDH1R132 and IDH2R172 mutations represent a novel class of point mutations in CN AML. Both mutations occur predominantly in CN AML, leading to overproduction of an oncometabolite, 2-hydroxyglutarate. These mutations are heterozygous in nature and mutually exclusive. Despite many similarities, it is possible that molecularly and clinically, they represent distinct subgroups. IDH1R132 is frequently accompanied by other mutations, whereas IDH2R172 is commonly the only mutation detected. Most AML cases with an IDH mutation, IDH1 or IDH2, are morphologically classified as AML with or without myeloid maturation (FAB M1 or M2), have morphologic evidence of dysplasia, and have a nondistinctive myeloid immunophenotype.
Upon completion of this activity you will be able to:
describe the physiologic role of IDH1 and IDH2.
describe the nature of IDH1 and IDH2 mutations.
discuss the characteristics of acute myeloid leukemia with IDH1 and IDH2 mutations.
The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit ™ per article. This activity qualifies as an American Board of Pathology Maintenance of Certification Part II Self-Assessment Module.
The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
Questions appear on p 163. Exam is located at www.ascp.org/ajcpcme.
We acknowledge the excellent technical services of Neelima Reddy and Xue Ao in performing the IDH1 and IDH2 assays.
- © American Society for Clinical Pathology


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Cup & Saucer is Portland's quintessential breakfast diner, with the weekend lines and loyal regulars its position implies, but its World Famous Garden Scramble ($7.75) feels a bit run-of-the-mill these days. It's good, sure, but as far as vegetarian-friendly eateries go, it's not very progressive. For a spicier start, try the black bean and Jack cheese omelet ($7.75) or Hell's Huevos ($7.25). And don't forgo the baked goods—the coffee cake and scones are delectable. (JG)
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The Truth about VITAMIN: C: Sodium Ascorbate versus Ascorbic AcidWhat's the truth behind Vitamin C Sodium Ascorbate? It's a different form of Vitamin C that is distinct from Ascorbic Acid. Sodium Ascorbate has more benefits compared to Vit. C Ascorbic Acid. Here are some not-so-known facts why we need Sodium Ascorbate or the SALT of Ascorbic Acid. Only about 1-2% of Ascorbate can be produced by our bodies – we need to supplement with this essential vitamins.
Beyond Whitening: L-Glutathione WondersYou must have heard about L-Glutathione skin whitening. But did you know that Glutathione does more than just whiten the skin? More important is that L-Glutathione supplements mainly prevent the onset of illness and ageing. There is more to beautiful skin involved with the use of Glutathione or Gluta for short. Discover its many wonderful health benefits.
$0.99Do you know what Spirulina is? Have you tried eating these, or taking them as supplements? Spirulina is considered as the "World's Healthiest Superfood." Find out why. Discover its amazing health benefits. Know which type of people need it. According to UN, Spirulina is the "best food for the future." For optimum health and wellness.


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Axis Large Outdoor Wall Sconce
from Hubbardton Forge
free shipping on most orders
Hubbardton Forge
Representing forty years of hand-made, Vermont-forged designs, Hubbardton Forge offers timeless lighting solutions that are built to last.
Rated 5 out of 5 by Anonymous from Great Product The Axis large outdoor wall sconce is a great product. It was a very easy install, and it looks even better in person than it did in the photos.
Date published: 2013-01-14
Axis Large Outdoor Wall Sconce is rated out of 5 by 1.
Is this light dimmable?
Hey there! This is dimmable with a standard incandescent dimmer. Thanks for your interest in this fixture. Should you require some additional clarification beyond this and would like to speak to a Product Specialist directly, feel free to give us a call anytime at 866.842.6209 and we can assist you. Thanks for contacting us! Stephanie, YLighting Team
Date published: 2015-10-26


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Middle School eNews
Thursday, October 27, 2016
Parents and Guardians are cordially invited to the annual AMS Open House on Wednesday, September 2 (7:30-9:00 p.m.). Open House is designed to acquaint our guests with the school's procedures and operations while providing our guests the opportunity to visit their children's classes.
Parents and guardians should arrive between 7:15-7:25 p.m. in order to receive a copy of their child's schedule in the Commons. From there guests will proceed to the Main Gymnasium bleachers for a 30-minute program that begins at 7:30 p.m. Items to be covered include reading schedules, parent group presentations, PowerSchool, programs and much more. Around 8:00 p.m. our guests will then proceed to follow their child's daily schedule (eight minutes per period including transition time – seven periods total). Teachers will be presenting materials about their class curricula and procedures.
This is a wonderful time to get to know the school and teachers better. We encourage you to attend. Please note that the AMS Open House is for parents and guardians only, not students. We hope to see you next week on September 2. If you have any questions, please call the Main Office at (440) 934-3800. Thank you!
Middle School Website |
District Website


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Fast & Furious 7 (2015)
- Rating
- Genre
- Action, Crime, Thriller
- release date
- April 03, 2015
- Director
- James Wan
- Written by
- Chris Morgan
- Cast
- Dominic Toretto, Dwayne Johnson, Jason Statham, Luke Hobbs, Paul Walker, Tyrese Gibson, Vin Diesel
'Furious 7′ Clips: Vehicle Hopping & The Rock vs. The Transporter(6)
Paul Walker goes vehicle-hopping in a new 'Furious 7′ clip, while another clip teases Dwayne Johnson's fight with Jason Statham.
'Furious 7′ Clip & Behind the Scenes Videos: A 'Fast & Furious' Family Reunion(8)
Watch a new 'Furious 7′ clip with Vin Diesel and Kurt Russell, then check out B-Roll footage from the upcoming 'Fast & Furious' movie.
'Furious 7′ Featurette: Meet the New Players(7)
The latest 'Furious 7′ feauturette offers a quick introduction to the new characters played by Jason Statham, Ronda Rousey, and more.
'Furious 7′ Early Reviews & International Trailer: A Ride Worth Taking(19)
The first wave of 'Furious 7′ reviews – from the movie's SXSW premiere – claim it's a terrific thrill ride and tribute to Paul Walker.
'Furious 7′ Plane Drop Featurette & TV Trailer Feature High-Flying Stunts(3)
A new 'Furious 7′ featurette goes behind the scenes of the vehicle sky-diving sequence that's featured heavily in the film's marketing.
'Furious 7′ Extended Preview & Poster: How About Some Fresh Air?(9)
The latest 'Furious 7′ preview offers an extended look at the car sky-diving sequence from the upcoming 'Fast and the Furious' movie.
'Furious 7′ TV Spot: Beyond Fast Lies Fury(5)
A new TV spot for 'Furious 7′ packages the movie's wild, airborne car stunts into an exciting thirty seconds of action entertainment.
'Furious 7′ International Trailer: You Ride, I Ride(4)
Dom (Vin Diesel) and Letty (Michelle Rodriguez) return home before trouble strikes in the new international trailer for 'Furious 7′.
'Furious 7′ TV Spot: The Hunted Become Hunters(6)
Dom (Vin Diesel) and his family take the fight to Deckard Shaw (Jason Statham) in a new action-packed TV spot for 'Furious 7′.
'Furious 7′ Trailer 2 Takes Fast (and Crazy) to a Whole New Level(46)
Universal Pictures has released a new 'Furious 7′ trailer – featuring Brian O'Connor (Paul Walker) and Dominic Toretto's (Vin Diesel) final ride.
'Furious 7′ Super Bowl Trailer: Fast and Flying Cars(28)
Universal Pictures has released a high-octane trailer for 'Furious 7′ during Super Bowl XLIX – with cars that are both fast and flying.
First 'Furious 7′ Trailer: Vengeance Hits Home(68)
The first trailer for 'Furious 7′ has been released, featuring Vin Diesel, Dwayne Johnson, and the late Paul Walker, who are being hunted by Jason Statham.
New 'Fast & Furious 6′ Featurette: More Story and Character Details(14)
The latest 'Fast & Furious 6′ featurette reveals more story details, including why Letty (Michelle Rodriguez) is working for the criminal Owen Shaw (Luke Evans). MILD SPOILERS within.
'Furious 7′ Review(92)
Furious 7 is another solid Fast and the Furious installment – one that (flaws aside) provides a nice farewell to star Paul Walker.
Furious 7 & Deadpool Kills Mario Lopez – SR Underground Ep. 190(55)
We review 'Furious 7,' discuss the 'Deadpool' movie costume and what we're hoping to see in the 'Full House' sequel series.
Project Almanac & Super Bowl Movie Trailers 2015 – SR Underground Ep. 181(27)
We review 'Project Almanac,' discuss the best Super Bowl 2015 movie trailers, and offer our impressions on the new 'Ghostbusters' cast, and the 'Fantastic Four' trailer.
Favorite Movies of 2014 & Most Anticipated of 2015 – SR Underground Ep. 177(29)
We look back at our favorite (and best) movies of 2014 as well as look forward to Screen Rant's most anticipated films of 2015!
Dumb & Dumber To & Doctor Who Season 8 Finale – SR Underground Ep. 170(10)
We review 'Dumb and Dumber To' and the 'Doctor Who' season 8 finale, as well as discuss updates on the 'Fantastic Four' reboot, the 'Fast and Furious' film series, and an 'Evil Dead' TV show.
Superhero Movie News Roundup – SR Underground Ep. 121(106)
Kofi and Dyce attempt to convince us why Gal Gadot could be a great Wonder Woman, then Rob, Ben, and Anthony web-sling future Spider-Man movie possibilities. Meanwhile, Perri still doesn't like Henry Cavill.
'Agents of SHIELD' – SR Underground Ep. 110(57)
We review the 'Agents of SHIELD' premiere, discuss the prospect of three more 'Fast and Furious' movies (as well as the problems of franchise filmmaking), a 'Walking Dead' spin-off show, and answer mailbags.
Deckard Shaw (Statham) is out for revenge against Dominic Toretto (Diesel) and his crew, following what happened to his brother in 'Fast & Furious 6.'


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My Thoughts On The Oscars As They Happen!
The show started with great dignity. Morgan Freeman came out and a friend of mine said, "Is that the one who fucks the granddaughter?"
Hilarious Billy Crystal pretaped montage of spoofs. To Octavia Spencer as she serves him pie: "It's your duty!"
Another friend: "This is already better than the Anne Hathaway one!"
The first two awards went to the stunning-looking Hugo. But don't worry, The Artist is going all the way. The Oscar voters love anything French (especially fries).
Upcoming Events
W.E. didn't win for costumes. Madge can't say "my Oscar-winning movie" after all.
British icon prosthetics showdown: Margaret Thatcher beat Harry Potter for Best Makeup! And Albert Nobbs could have used more razor stubble.
A friend: "Sandra Bullock always looks like she's about to cry." Well, the Oscars probably bring back horrid memories of the Jesse James mess.
Looks like Jessica Chastain is with her mother. So she's a gay man!
The Mr. Ed theme, the Wizard of Oz skit. This show is for really old people! Like me!
I have no idea what that Cirque de Soleil number had to do with anything, but it was amazing. Take note, Spider-Man.
Christopher Plummer wins for playing a man who comes out at 75 and bags a hot boyfriend. I should have waited to come out!
Angelina is standing in a come-hither way that says "F**k me." Does she walk around the house like that?
J. Lo's ass is competing with her nipple -- and Angelina's leg -- for Body Part That Will Make the Most Late-Night Monologues Tomorrow.
Don Rickles looked hotter than Warren Beatty. Did you ever think that would happen?
I knew the women with the acid in their face would win. Last year, it was kids with cleft palates or something.
Meryl looks like an Oscar!
This show is skewing so old. But there are younger folks coming up. The death montage!
Best Actor is Jean Dujardin. I foolishly stuck to my choice of Clooney. Clearly, all the SAG winners go on to win Oscars. The element of surprise is nil.
No, scratch that. Yay, Meryl! I am so happy to have been wrong in my prediction. What a feel-good moment. The right choice! Who else could have made you feel for Margaret Thatcher?
And as predicted, The Artist copped the big one. French people are being allowed to take over Hollywood -- as long as they make silent films.
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Orland Park School Bus Driver Charged With Slapping 4-Year-OldLinda Bell, 63, faces a felony count of aggravated battery to a child, according to Orland Park police.
No Bail For Woman Charged With Abusing 7-Year-Old SonThe wounds, bruises and burns on the boy's body were the most injuries the doctor examining him had ever seen on a human being, Assistant Cook County State's Attorney Lorraine Scaduto said.
Chicago Non-Profit Seeking To Prevent Child Abuse And NeglectEvery year, 2.9 million cases of child abuse are reported in the U.S. In Cook County, there were more than 8,000 child abuse and neglect cases reported last year. It's those numbers that inspired Melissa Moss to start the local non-profit Kids Have Hope.
Toddler's Death In Austin Ruled HomicideAn autopsy found 2-month-old Katana Greenlee died of blunt force trauma to the head from child abuse.
Dad Gave 6 Excuses For Infant Son's Death, Prosecutors SayBrandon Holman kept changing the story of how his 2-month-old son Bryson ended up dead, Cook County prosecutors said.
Ashburn Infant Dies From Child Abuse InjuriesBryson Holman, of the 3200 block of West 83rd Place, was pronounced dead at 12:05 p.m. Saturday at his home, according to the Cook County Medical Examiner's office. An autopsy Sunday determined he died of multiple injuries caused by abuse, and his death was classified a homicide.
Police Ask Adults To Be More Alert To Signs Of Child Abuse And NeglectThe Aurora Police Department has urged residents to be more aware of the signs of child abuse, and not to fear calling police to check out any suspicions.
Mother's Live-In Boyfriend Charged With Abuse Of 7-Week-OldAnthony Briden, 21, of the 400 block of South Belmont in Elgin was charged with two felony counts of aggravated battery to a person under 13, according to a statement from Elgin police.
Evanston Man Charged With Shaking NewbornAn Evanston man was charged with aggravated battery to an infant after police say he admitted to shaking his 24-day-old daughter who would not stop crying, police said.
Official Raising Money To Bury 11-Year-Old Waukegan Child Abuse VictimAn 11-year-old victim of child abuse dies and to make this story even sadder, there's not enough money to bury the child.
Baffoe: Sorry You're Not Sorry, Brandon MarshallMarshall's press conference missed the mark Thursday, writes Tim Baffoe.
Back To School Means Spike In Child Abuse ReportsState child welfare officials say it's too hard to tell whether there's been an increase in reports of child abuse since news broke about Vikings running back Adrian Peterson taking a stick to his four-year old son.


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Rider scored its last seven points at the free-throw line in the last 1:50 of play to hold off the Siena women in a 73-70 MAAC win at Alumni Gymnasium on Friday night. Siena's Emia Willingham had hit a pair of free throws with 2:05 left to play, tying the game, 64-64. Rider responded with a three-point play from Mikal Johnson with 1:50 left for a 67-64 lead. She was fouled by Kelsey Booth on ...
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Welcome to the 2016 Orcas Island
Bird & Wildlife Festival!
Friday, April 29 to Sunday, May 1 on Orcas Island
The San Juans are lush with wildlife. And the Orcas Island Chamber of Commerce's upcoming festival will pay tribute to the splendor of the outdoors.
"In our third year, the festival is celebrating the wildlife in and around Orcas Island," said Chamber Director Lance Evans. "Whether you are exploring on land or in the Salish Sea, we are encouraging everyone to take part."
Participants can enjoy nature talks, wildlife tours and attend a dinner presentation from keynote speaker Joe Gaydos. The festival is also partnering with chamber members to offer whale and wildlife tours. Outer Island Excursions, Deer Harbor Charters, Orcas Island Eclipse Charters and Shearwater Kayak Adventures are participating.
Dr. Gaydos, director and chief scientist with the SeaDoc Society, will present "The Amazing Wildlife of the Salish Sea" at The Loft at Madrona in Eastsound on Saturday, April 30 from 6 to 9 p.m. Tickets for the three-course dinner are $50, and are available by reservation only. A silent auction will also feature great Orcas Island gifts. The Festival Dinner is Sold Out.. our regrets.
Contact the Orcas Island Chamber of Commerce at 360-376-2273 for tickets.
"The festival is a great way to enhance our own knowledge about the beautiful environment we live in as well as share it with visitors," said Susan Gudgell, chamber board president.


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The full range of luxury products from London-based bath and body brand Molton Brown line the shelves here. Detoxifying shampoos and soaps with the luscious scents of plum, orange blossom and kaffir lime will make your home seem like a fancy hotel, as will the beloved thai vert soothing hand lotion.
|Venue name:
|Molton Brown (CLOSED)
515 Madison Ave
New York
|Cross street:
|between 53rd and 54th
|Opening hours:
|Mon–Fri 10am–7pm, Sat 10am–6pm, Sun noon–5pm
|Subway: A,C to High St; F to York St.
|Do you own this business?


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Companies, Communities Step Up to Inspire Nations to Help Syrian Refugees
If Nova Scotia's Mi'kaq First Nations are successful in their petition to the Canadian government, the island of Cape Breton will be a new home for Syrian refugees. And if the Israeli company SodaStream gets its way, it will be able to provide jobs for 1,000 refugees – in Israel. A variety of companies and communities are stepping up to help the burgeoning flow of refugees – in some cases, to the consternation of their governments. Is this the new humanitarian movement, or just a gentle encouragement for governments to help? Either way, they are committed to making a difference in Syria's humanitarian crisis.


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Tree Talk: Trees are one of Tunica's biggest assets
During our first meeting of the tree board, we discussed the many problems the town is having with our beautiful old trees, as well as maintaining our downtown trees. We also have the job of replacing some of the trees that are in need of a major overhaul.
We can all do our part in keeping our old established trees alive and well by doing a yearly wellness check of our trees. Think of a healthy tree as an investment. A healthy tree increases in value with age, increasing our property value, beautifying the surroundings, purifying the air, saving energy by providing cooling shade in the summer and protecting from winter winds.
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Lamarr Moore found guilty of attempted murder, felonious assault.
Layoffs loom if renewal is defeated in Toledo.
Intervention key to better justice system.
Sheriff out during criminal proceedings; no appeal seen.
Man shot at least once in the 500 block of Austin Street.
Emergency crews say it boosts odds of survival.
Neighbor called area of the city a war zone
Should the vote fail, both departments expect significant layoffs
Fire was at vacant house in East Toledo
A black man reportedly acting erratically at a strip mall pulled an object from his pocket, pointing it at officers and assuming a "shooting stance," authorities said


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Warm weather here greeted with Christmas music on the radio
WRIT-FM (95.7) became the first station in Milwaukee to flip to an all-Christmas music format at 7 a.m. Wednesday morning. The Clear Channel station was billing itself on the air as Milwaukee's Christmas station. It was the latest start for the format in years.
The first song played was "Have a Holly Jolly Christmas," by Burl Ives. »Read Full Blog Post(9)
Comedian Gaffigan savors New Year's in Milwaukee
Pasty comedian Jim Gaffigan has become such a New Year's tradition in Milwaukee that Point Brewery in Stevens Point bottles a special beer in his honor for the shows - aptly titled "Jim Gaffigan Pale Ale."
This will be the sixth year that Gaffigan, 46, performs at the Pabst Theater around New Year's. Beside the fact that tickets continue to sell well (he's playing three shows from Saturday through Monday this year) there's another important reason why he keeps coming back. »Read Full Article
Free and bargain ebooks for Kindle, Nook, ereader users
If someone gave you a Kindle, a Nook or another ereader for the holidays, or you're curious about reading ebooks on your new smartphone or tablet, here are a few sites to bookmark or follow via RSS to help you fill up your devices.
On Tap Today: Merry Christmas at the movies
If you're like my family, you get up on Christmas morning excited to open the gifts under the tree, to dig into a ham dinner, to spend quality time with loved ones...and then you need to get the heck out of the house. That's why I've spent many a Christmas night at the movies.
And of course, I'm not the only one. Christmas Day is one of the year's biggest holidays for new movie releases, and this year is no exception. »Read Full Blog Post


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Qantas 1 rotates early on runway 16R into a 35 knot southerly.
Scanned from a 35mm negative.
Landing on the shorter Runway 07 at Sydney Airport.
Crashed at Tokyo Narita on 23rd March 2009. May the crew R.I.P.
Commemorating the 70th Anniversary of the Kokoda Campaign. 1600px
Passing the Melbourne Central Business District denoted by the tall buildings while on base leg for runway 34 at Melbourne's Tullamarine Airport.


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McDonald's Commercial: Easy Morning
McDonald's and advertising agency DDB Tribal Vienna have released this beautiful video ad lately. The spot is from a recent campaign, which previously has released a funny print, which depicted a long sleeved sweater. The video features a guy and his hard morning – not only he gets entangled in the sweater's sleeves, but the shoes run away from him laughing!


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Steve Davis: My Beef With Ravens Off-Season ProgramIn the last CBA, they decided they wanted to cut down on the work the players were being asked to do under the guise of protecting them from injury... here's why that's a BAD thing.
Sports Rehab: George Atallah Of The NFLPAAssistant executive director of external affairs of the NFL Players Association George Atallah joined Glenn Younes and Bob Haynie on Sports Rehab to discuss the new salary cap, collective bargaining agreement and Ray Rice.
Sports Business Journal's Dan Kaplan Breaks NewsDan Kaplan joins Ken Weinman and Vinny Cerrato with breaking news about 8th Circuit Court of Appeals' decision on the NFL Lockout.
NFL Player Agent Tony Agnone Talks Free AgencyNFL Player Agent Tony Agnone joins Ken Weinman and Vinny Cerrato to discuss the intricacies of the upcoming free agency period.
SI.com's Don Banks On The Mark Viviano Show
NFL Player Agent Tony AgnoneIs a lockout in store for the NFL? As the March 4th deadline quickly approaches, NFL player agent Tony Agnone gives an in-depth analysis of the Collective Bargaining Agreement talks.
SI.com's Don Banks


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|Thread Tools
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|26th April 2008, 03:00 PM
New Member
Join Date: Mar 2008
Posts: 10
severne codered vs. NP RS:Racing
hi, what of this sails is best? speed, control ?
Patrick Simiglai
|26th April 2008, 03:17 PM
Join Date: Aug 2006
Posts: 329
Easy... CodeReds won't perform, NP will break masts... so it depends on what you prefer...
|27th April 2008, 07:54 AM
Posts: n/a
I will translate that for you. Geo means get a Maui sails Tr-4
Oh, you wont be able to carry it as its so heavy unless you buy the special order version.
And to save the next reply, better get a carbon art as well why you are at it
|27th April 2008, 11:37 AM
Posts: n/a
hmmm.. what about V8 vs MS-2 vs Overdrive vs S-type?
Which is the best in a 10m size on a formula for a lightweight sailor?
things to compare are low end power / stability when the wind picks up / weight / handling on the water / durability?
So many choices for free-race sails on the market! Appreciate it if the windsurfers who have had experience blasting on these sails would chip in if their advice and opinions!
|27th April 2008, 04:59 PM
Posts: n/a
I've used recent S-Type and GTX in large sizes. My impressions are not scientific but the GTX 10.5m was beautiful to use, and my favourite. Tushingham Lighting is very nice too. My V8 is an earlier edition so perhaps not fair to say it doesn't quite match up, feeling 'heavier' in use. It's actually pretty heavy on the scales too, and the static weight is something you certainly notice trying any of the full race sails after the best freeracers. Interesting Maui do a special light version, didn't know that, at least they own up to the 8.4kg weight of their standard 12.- Many brands don't quote a weight, which when you think for example of the emphasis placed on mast weight, is crazy. I do know Aerotech can do a Pentex version of their VMG, and user feedback is that it makes a real difference.
Seems like most riders don't want to bother with this big kit, and I've gotta admit theres a case sticking to freestyle practice when it's light. But skimming effortless over the flat water at a windspeed multiple, and making the use of every little puff to work upwind is absorbing and satisfying to me.
|28th April 2008, 02:17 PM
Join Date: Aug 2006
Posts: 329
Unregistered (post #3),
I didn't say that... but if you do... only believe me, I wouldn't have commented if the choice was, say, between North Sails Warp and Gaastra Vapor; even if, as you say, I have strong preferences. Point is that, to my eyes at least, Neil Pryde looses any credibility by giving a 6 months warranty on race masts (in EC 24 months is the law), and Severne by spraying the film. Meaning NP can't solve their technical issues and Severne tries to appeal buyers with means other than performances.
Anyhow: it doesn't seem to me that TR-4 sails are that much heavier than competitors to make any difference. Fact is, usually TR-4 are rigged on heavish Maui Sails booms that add some to rig weight. Recently I rigged a 7.0 TR-3 on an old Fiberspar 180-226 carbon boom and it felt featherweight; but since when I am using the Maui Sails boom, I am addicted to it and easily swap some weight saving for the hyper stiffness and sturdy build.
From a more technical point of view, 9 battens are heavy indeed, but this way you can have stability beyond reproach AND a soft feeling, easy to use sail. Other makes as an instance seeks stability using extreme mast bends, with obvious consequences... again, it's a matter of preferences...
Last edited by geo; 28th April 2008 at 03:40 PM.
|28th April 2008, 05:00 PM
Posts: n/a
I've had lot of doubts this winter before choosing the sails for the new season.I've talked a lot with GEO about it.I came from NP and North experience.During that period I've had some chance to test tr-4's.Plus I've competed in a national slalom comp where many of my beliefs have been resetted.But,if I have to report what I've seen,Severne was second in a strong fleet (where Point 7 won).
Does it mean they're fast or slow??
In my opinion,as GEO says,there's not a noticieable fastest sail and there's no way to really achieve that point.In a comp there are so many variables that influence your speed that you really can't say what's best.And if you look at a "freeride" sailing MS has shown how fast they really could be (50+ !).
I didn't liked so much MS (just because my background is far way different) but I coudn't ever say they're slow.
As always it's a matter of preference,confidence in what you sail and how much you're willed to right trim the stuff.
|29th April 2008, 10:18 PM
Join Date: Aug 2006
Posts: 1,483
Except from a slight difference in thermal dissipation kinetics between black (quicker) and white (slower; see black body physical principle), color doesn't matter to perform better in a sail.
As for surface spray-painting per se, it may matter for a fin but I strongly doubt it for a sail where air is 1000x less dense than water.
Finally, on a personal note, the difference for a lightweight between a NP RS6 10.7 and a CodeRed2 11.0 sail is pretty much obvious : just ask the lactic acid content of my sore muscles at the end of the day. Nothing to do with the color, believe me...
Cheers !
Last edited by Jean-Marc; 29th April 2008 at 10:26 PM.
|29th April 2008, 10:50 PM
Join Date: Aug 2006
Posts: 1,483
...well, on a second thought, color may matter security wise. If sailing in rain, mist or fog, at least in my opinion after 1 year of use, the Code Red is more visible far away than transluscent, black or white sails and may help you to avoid collision with your buddies or other sailing crafts as well. Another point is whether you better like to be in safe or in stealth mode and how to deal with the unexpected odds on some instances (e.g., search & rescue in bad weather). Your call...
Cheers !
|29th April 2008, 11:10 PM
Join Date: Aug 2006
Posts: 329
Last edited by geo; 29th April 2008 at 11:17 PM.
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Anesthesiologist (pain control)
20 years of experience
20 years of experience
4440 W 95th St
Oak Lawn, IL 60453 Phone number & directions
Oak Lawn, IL 60453 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
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This light came on today for the first time on my Astra Sport. At first it was brief and seemed to be on downhill braking. Then was on permanently but as switched back to occassionally.
Noticed that it twice seemed to idle erratically and stalled once in 2nd with clutch in rolling at 10mph.
The car sounds fine and goes as well as it used to. Any ideas what this could be?
Is it gonna cost a lot to?
Urgent help needed.


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This business is not BBB accredited.
CSL Construction L.L.C.
Phone: (808) 621-9206 Fax: (808) 664-8507 PO Box 860997, Wahiawa, HI 96786 http://www.cslconstruction.net
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Uplifting Addicts for a Brighter INDIA…Rise Foundation
We provide treatment facilities to Drug Addicted people, Alcoholics and Mentally Challenged people. We are a team of Psychiatrists, Psychologists and Social Workers. Our primary purpose is to provide the best care for patients. We try to put our 100% efforts to make these kind of patients socially accepted . We train them in a… Read more »Sreeniketan Rehabilitation Centre for Addict Kamyab Foundation
We have built this Center keeping in mind most of the requirements of the Clients.We have decided to run it on a "No Loss No Profit" basis. We are s trust registered by the Charity Commision. We firmly believe in dealing with our Clients in a loving & dignified manner.The Managing Trustee who runs the… Read more »Sarvoday De-Addiction Centre
Sarvoday De-addiction Centre give you a treatment base on twelve step program of Alcoholic and Narcotic Anonymous of recovery, it help you for stay sober and teach you how to leave without alcohol or drugs, live in natural environment with Nutritive and Hygienic food, regular visiting doctors and psychiatrists, powerful lectures and counseling sessions, special… Read more »Rishikul Sewa Samiti, Rishikesh
An open air 12 step recovery program is offered by us in the spiritual city of rishikesh near the banks of the holy river ganga in the supervision of highly traind and experinced councillors.detoxification facility is also available.Awaken Convalescent and Halfway Home
Awaken is located off Hennur Road, Bangalore North at Doddagubbi, an ideal setting for self-reflection. Spread across 30,000 square-feet, this residential rehabilitation facility, where both men and women are treated. Set amidst an absolutely beautiful and tranquil location, surrounded by lush greenery, we have an outstanding treatment program to match these aesthetics. We have a… Read more »Amrita Foundation
For individuals, families, and communities struggling with addiction to alcohol and other drugs, Amrita Foundation helps people transform their lives by providing the best addiction treatment and recovery services as well as education, sensitising community regarding various mental health issues, training and research. We also emphasises on providing therapeutic services for other psychological and adjustment… Read more »


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Adriana Lima's Breasts Look Huge!
Here's Adriana Lima posing in some skimpy outfits for El Pais Semanal, whatever the hell that is, looking her usual hot ass self. Her tits look absolutely huge in these pictures and she is by far the best at making erotic facial expressions. Now if only I could convince her to make those faces for me, I'd have to pay her because there's no way I could make it happen on my own merits. She's Brazilian, they're in to some weird shit, I've seen it on the internet. Related Articles: Adriana Lima Gives Good Face Adriana Lima Forgets To Wear Her Bra Adriana Lima Because She Is Hot Adriana Lima's Got Nipple -Itis
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Rihanna Is See Through, Yum!
So Hot, I Want To Marry!!!
Super Naughty Girls Take Selfies
The Perfect Tight Booty


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Ethylene Glycol (MEG)
Ethylene Glycol (MEG) Topic
Find a wealth of information on the Ethylene Glycol (MEG) topic on this page. Get the latest headlines, trending topics, related companies, additional news and social media. If you'd like more information on the Ethylene Glycol (MEG) topic, give us a call at +1-310-553-0008.
Ethylene Glycol (MEG) Latest News
PTA and MEG manufacturer Loop Industries receives positive opinion letter confirming US FDA approval of its tertiary PET recycling process; finished products would be suitable as packaging materials for food-contact useJul. 25, 2016, Marketwire LP
UAE-based MEGlobal's planned MEG production facility on the US Gulf Coast in Texas will have a 700 kilotonnes/year capacity, come online in mid-2019 and use Dow Meteor process technology and catalyst; unit will be MEGlobal's first in the USJul. 08, 2016, Business Wire
LACC, a JV among Axiall and Lotte Chemical, holds groundbreaking ceremony for upcoming ethane cracker in Calcasieu Parish, Louisiana; cracker to produce 1 million tonnes/year of ethylene, and Lotte to also construct an adjacent ethylene glycol plantJun. 16, 2016, Business Wire
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text:
Du trenger Garmin Express for å laste ned dette produktet.
The GPSMAP 2110 and its counterpart, the GPSMAP 2106, bring you bold, sunlight-readable color, high-speed processing, and a comprehensive worldwide basemap that lets you take to the seas anywhere in the world — literally.
With the GPSMAP 2110's large 10.4-inch diagonal screen, you'll get incredible contrast and detailing, even in direct sunlight. The enhanced worldwide basemap contains shorelines, highways and surface features in rich, colorful detail. Tough enough to withstand rain, sunlight and saltwater spray, the case is fully gasketed and water resistant to IPX7 standards. The 2110's slim-line design also makes it easy to install in cabin bulkheads or open cockpits.
For added convenience, you can connect your 2110 to a sounder or other chartplotter with CANet™, Garmin's proprietary 1-megabit Controller Area Network that allows you to view and control sonar information from chartplotters located elsewhere in your boat.
The 2110 accepts optional BlueChart g2 data cards, which bring you 3D maps, tides and currents, depth contours, navaids, port plans, marine services, points of interest (POIs), photo references and more. These maps also offer you a choice between 3D "mariner's eye view" or the traditional 2D direct-overhead view to help you visualize your way around busy harbors, navaids or tricky coastlines.
GPSMAP 2110: Take to the seas anywhere in the world
Trenger du kart for andre regioner? Se alle kartene som er kompatible med denne enheten.
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realmagick.com The shrine of knowledge.
Deccan Plateau
- A plateau of south-central India between the Eastern Ghats and the Western Ghats. The name is also used for the entire Indian peninsula south of the Narmada ...
- THE DRY MONSOON OF THE DECCAN PLATEAU, INDIA Professor
- the Deccan Plateau of south India where various means have been developed, including the building of large reservoirs, to capture and hold water for the dry ...
- www.oneonta.edu
- Plateau - Eklavya
- the Narmada River is called the Deccan Plateau. The part to the north of the Narmada is called the Northern Plateau, which is divided into the. Malwa Plateau in ...
- www.eklavya.in
- Wildlife studies in neglected ecosystem of Deccan plateau - BNHS
- 1. Study of wildlife from neglected ecosystem of Deccan plateau of Maharashtra, India. Project I: Study of Flora and Fauna of Solapur Super Thermal Power ...
- bnhs.org
- Temperature stratification of the atmospheric boundary layer over
- Temperature stratification of the atmospheric boundary layer over the Deccan Plateau, India, during the summer monsoon. S. S.
- www.springerlink.com
- The Convective Boundary Layer over the Deccan Plateau - Springer
- The thermodynamic structure of the Convective Boundary Layer (CBL) over the Deccan. Plateau, India has been investigated using serological data during the ...
- link.springer.com
- Wagoner Wins Book Prize for Deccan Plateau Research
- Professor of the Archaeology Program and Professor of Art History Phillip Wagoner was recently awarded the Ananda Kentish Coomaraswamy Book Prize for his book entitled "Power, Memory, Architecture: Contested Sites on India's Deccan Plateau, ...
- Need More Centres for Deccan Studies: HK Sherwani Centre Director
- HYDERABAD: With the HK Sherwani Centre for Deccan Studies at Maulana Azad National Urdu University being the only centre in the country offering specific studies on the Deccan region, the centre's director Salma Ahmed Farooqui stresses the need for ...
- Why save the rocks of the Deccan Plateau?
- As our Institute at Hyderabad started constructing a new building, we found a huge boulder on the site. Such boulders and rocks are common place in Hyderabad (and indeed in the Deccan region) and many builders have simply blasted them away to make ...
- Tibetan plants can signal arrival of monsoon: Study
- Beijing: Tibetan alpine meadow plants are sensitive to rainfall and can forecast the arrival of Indian monsoon, according to a first-of-its-kind study which focused on vegetation regreening on Qinghai-Tibet Plateau.
Deccan Plateau is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Deccan Plateau books and related discussion.
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realmagick.com The shrine of knowledge.
- How pay-to-play is affecting musicians, too
- The drummer of former metal band Sciomancy, who prefers to go by J.P., shares a similar experience of working with Keynote for a show at DV8 in Providence opening for a touring band on a Sunday night.
- How do you spell stressed at the national bee? MOM
- FORT WASHINGTON, Md. — There is a three-letter word for stressed that all the contestants know well at the 2013 Scripps National Spelling Bee: M-O-M. Just ask Nickolas Day, 14, of Baton Rouge, sporting a bright blue shirt with "Spell Checker" stamped ...
- NY's Arvind Mahankali wins National Spelling Bee
- FORT WASHINGTON, Md. — Arms behind his back in his signature stance, Arvind Mahankali spells on his hand, looking up at the pronouncer as he correctly spells "tokonoma.
- Keeping What Is Old, New Again: Contemporary Cabinet Cards
- Even with new technological advances in how we create photographs, there are still practitioners that like to hold on to the past. People in the photography industry refer to older photographic processes as "alternative processes.
- Fallacy of branding
- Pointing towards his piece Sciomancy, in which an elderly bearded man wears a robe made up of "Ah Long" (illegal money lenders) loan stickers, Akhmal reveals it is a metaphor of how people were now "wearing debt" by buying branded clothes they cannot ...
Sciomancy is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Sciomancy books and related discussion.
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Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Sciomancy Topics
Related searchesche guevara capture and execution
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See: http://blogs.testbit.eu/timj/2005/08/08/08082005/ (page moved)
scsi0: ERROR on channel 0, id 12, lun 0, CDB: Read (10) 00 03 8d 14 70 00 00 08 00
Current sda: sense key Medium Error
Additional sense: Unrecovered read error
So i went out earlier today to get a new hard disk (a fast, quiet and cheap P-ATA from Samsung – i'm slowly replacing all SCSI devices here) and put it into my development machine, taking proper care of grounding and unplugging everything appropriately. Believe it or not, once i turned everything back on, the BNC input of my 21″ monitor died. Double checked graphics card, connections etc, tried the monitor on the laptop… nothing. That input stage simply burned out. Bummer. Ok, so i'm using the D-SUB input now (luckily that monitor has two inputs) to copy over the disk contents to the new drive. While i'm writing this, that hot ol' SCSI lady (you can't touch it while it's running, it's way too heated) is making an awfull lot of noise on some sectors, kinda scary since i'm still copying some relevant development files.
Always remember, skip you not the daily backup!


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WholeHome CASUAL(TM/MC) 200 GSM Faux-Mink Microfibre Sheet Set
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- 2 standard-size pillowcases (twin has 1)
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