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AAEP Convention 2005: Vaccine Efficacy and Controversies
- Feb 1, 2006
- Topics:
"There are a huge number of (vaccine) choices out there and it's hard sometimes to see our way through the forest," said Julia Wilson, DVM, Dipl. ACVIM, associate professor in Veterinary Population Medicine at the University of Minnesota. "What we should be doing is thinking about what the risk is of that disease, not just for the individual horse, but the group of horses it lives with. Think good and hard about how good the vaccine is, its safety, and whether that horse is going to be at risk for adverse effects."
Wilson encouraged veterinarians to think critically about vaccine recommendations during the In-Depth: Vaccination session at the 2005 American Association of Equine Practitioners' Convention, held Dec. 3-7 in Seattle, Wash. "Think of where the horse is going to be going over the next year," she said. "We have had really bad strangles in the Midwest, for example. So if you don't have strangles in your area, and you have a client that wants to move to the Midwest, that's one I want you to think about."
Remember that seasonal risks are longer for arboviral diseases (those spread by mosquitoes) in some areas such as Florida, so horse owners should have their horses boostered with vaccines against encephalitis (Eastern equine encephalitis, EEE, and West Nile virus, WNV) if they're planning to travel to events such as the Florida winter show circuit. Some diseases tend to be more regional; for example, mares going to the breeding shed in Kentucky should be vaccinated for rotavirus and botulism. Wilson included a "Risk Assessment for Vaccination Decisions" form in the convention proceedings, for horse owners to complete before consulting with their veterinarian about vaccination.
Wilson encourages veterinarians to look at not only the individual's risk of exposure to diseases, but the entire farm's risk. She said, "I would like to advocate that, whenever possible, we convince facilities to have a policy where they don't bring unvaccinated horses or horses with unknown vaccination status to the facilities." She also promotes open lines of communication. "We need to share when we have a contagious disease (with the community) for the best interest of the horses. There has to be some way around the client confidentiality where we can let each other know about outbreaks without violating that."
Vaccine Efficacy
"The type of vaccination we select influences the type, strength, and duration of immunity," Wilson said. How can true efficacy of vaccines be determined? Experimental models of disease vary--some closely mimic naturally occurring disease and others remain controversial--and all results should be interpreted with caution.
Along with and sometimes in spite of what efficacy studies show, Wilson stresses the importance of veterinarians explaining to their clients that vaccines are never 100% efficacious--there will always be some upsets.
"Vaccines most often reduce the severity of clinical signs and/or duration of the illness, which translates to lower morbidity (illness rates) and lower mortality (death rates)," she explained. "These important points must be stressed to clients, who are quick to blame vaccine manufacturers when a vaccinated animal develops clinical disease or seems to have brought strangles, influenza, or herpes back to the farm after an excursion or competition."
While it's not common, it's important to note that vaccinated animals can carry infections home to the herd. "Vaccination is not a substitute for quarantine, but something we can use in addition to it," Wilson said. "I think we not only need to push vaccinating, but understand the practices to keep from bringing other diseases in."
If an infectious disease hits a farm on which the majority of horses are vaccinated against that disease, Wilson said that horses will shed less virus and can return to use more quickly after the disease runs its course. She recommends vaccinating horses well before they experience the stress of change (such as from sales and shipping), and she recommends quarantine of new arrivals for at least four weeks before allowing them to mingle with resident animals.
Modified live vaccines produce a stronger immunologic response than killed vaccines that use adjuvants to enhance signaling of the immune system. This means modified live products can prevent disease better, but they also have a greater risk of side effects, including shedding the vaccine strain. Killed vaccines typically have a shorter duration of immunity, so it's important that you schedule administration of killed vaccines for seasonal diseases (such as encephalitides and Potomac horse fever, or PHF) shortly before the risk is anticipated. Wilson recommended that some killed vaccines be given every two to three months in high-risk environments (influenza vaccines in a herd of young horses, for example). "Even then, not all horses will have high titers that are predictably protective," she added.
Adverse Effects
"Every vaccine we put into our animals has the potential to cause an adverse effect including anaphylaxis (A rapidly developing, exaggerated, and sometimes life-threatening allergic reaction) and death," Wilson said. Sometimes you can prevent problems simply by following the instructions. "What I didn't realize until I started putting this talk together is that there are some vaccine companies that don't want us putting their vaccine in the neck (Potomacguard and Pneumabort, for example). We should pay attention to those recommendations."
She made the following important points on avoiding adverse reactions:
- Do not vaccinate through dirt or mud on the horse's hair--clean up the horse before injecting vaccine. This can help avoid clostridial infections at the injection site.
- Do not allow your vaccines to freeze; this increases the adverse reaction rate.
- Watch for purpura (an immune reaction that typically causes hives and edema in the abdomen, limbs, head, and scrotum) or immune-mediated thrombocytopenia (low blood platelet count) after strangles vaccination. "It's a very rare thing to happen, but we need to remember before we make blanket strangles vaccination recommendations that these risks are present," she said.
- Store the vaccines in the dark at the recommended temperatures. Check the color of the vaccine before using it; many vaccines have color indicators that signal microbial growth. If the vaccine has a color indicator and the product has turned red, don't use it.
- Never mix vaccines in the same syringe with other products. There is potential for cross-reactivity and adverse reactions.
- Again, check the directions--those of at least two products (Calvenza and Cephalovac) tell you not to put the booster at the same place you put the first vaccine.
- Faithfully report reactions at www.aphis.usda.gov/vs/cvb/html/adverseeventreport.html.
- Use silicone-free needles on horses that have reactions to the coating on disposable needles.
- Consider non-adjuvanted vaccines in the future, perhaps intranasal ones.
- Consider using concurrent antihistamines or an immunomodulator (http://www.TheHorse.com/emag.aspx?id=6582) to vaccinate the horse that tends to develop hives.
Specific Vaccine Controversies
Strangles--In my opinion, we have three choices out there: Strepgard (M-protein inactivated intramuscular, or IM, vaccine that requires two initial vaccinations), Strepvax (inactivated IM vaccine that requires three initial vaccinations), and Pinnacle I.N. (a modified, attenuated live bacterial intranasal vaccine)," she said. "We must remember these vaccines do not always prevent the disease, they just diminish clinical signs."
Label recommendations suggest that only yearly boosters are needed with these vaccines, but Wilson reports many farms with endemic strangles found that semi-annual vaccination was more effective in reducing morbidity when using the IM vaccines.
However, she added, "My experience in the Midwest is that Pinnacle provides much stronger protection than the M-protein vaccines and it has been successfully used in outbreaks."
In high-risk environments, Wilson recommends administration of Flu Avert I.N., a cold-adapted, modified-live intranasal vaccine, every six months. This is in contrast to every two to three months for the older killed-virus IM flu vaccines. The exception is in pregnant mares, in which the intranasal vaccine doesn't produce high-circulating serum titers, so foals would be protected only minimally by the antibodies provided in the colostrum. Wilson suggests veterinarians incorporate an intramuscular product such as Calvenza (which can be used intranasally as well) into the pregnant mare's regimen.
Vaccinating in the Face of Exposure
"With West Nile virus (WNV) in 2002, vaccination in the face of exposure seemed to work quite well, and later use of Recombitek (the Merial canarypox-vectored vaccine) appeared to thwart that disease in California," said Wilson. In Minnesota's dealings with WNV, Wilson has recommended that vaccination in the face of the illness is acceptable so long as clients realize that the vaccine will not have time to become fully protective. However, "Equine herpesvirus type-1 (EHV-1) is one disease where you don't go vaccinating in the face of exposure in the neurologic form," she stresses, reviewing the neurologic EHV-1 outbreak at the University of Findlay in Ohio (www.TheHorse.com/emag.aspx?id=4104). "At the Findlay outbreak in 2003, they had 118 horses, 40 of which developed neurologic signs. Then it got into Ohio State through some of the transferred patients…it was a big deal."
Wilson said in the Findlay population, horses that had been vaccinated with a modified-live vaccine (Pfizer's Rhinomune), appeared to be better protected than those vaccinated with some of the killed-virus EHV vaccine products. She referenced the study by Cornell researcher Klaus Osterreider, DVM, DVM Habilitation (German equivalent to a PhD), that examined the modified-live vaccine's efficacy against neurologic EHV-1 (www.TheHorse.com/emag.aspx?ID=5809). "Rhinomune perhaps should be reconsidered in horses that are at a high risk of exposure," she suggested.
Vaccinating after Natural Infection
Little information is available on this topic, so Wilson could only make general recommendations. A horse that has recovered from a clinical case of strangles seems to gain long-lasting strangles immunity, with many horses never developing clinical disease later in their lives. She suggests you wait a year after infection and then resume vaccination with strangles. Horses that have had purpura may again develop signs following vaccination, hence checking titers first and avoiding vaccination if the titer is high has been suggested. The exception to long-lasting immunity would be in horses that have Cushing's disease; these horses tend to be a bit more susceptible to infectious diseases because their bodies' high cortisol levels can induce immunosuppression.
Veterinarians need to better understand the pathogenesis of EHV and PHF before making solid recommendations on revaccination following natural infection with these diseases, she said.
Overvaccination vs. Titer Levels
"Are we overvaccinating?" Wilson asked. "It depends on the horse and the circumstance. Some horses get vaccines they don't need, but many more horses aren't getting the protection we can offer them." She offered a list of her vaccine recommendations:
Non-negotiables/Core Vaccines:
Arboviruses (EEE, WEE, and WNV)
Strongly Recommended:
Recommended if Exposure is Likely:
EHV-1 and/or EHV-4
Farm- or Horse-Specific Risks Only:
Potomac horse fever
Equine viral arteritis
Leptospirosis (extralabel)
Lyme disease (extralabel)
Clostridial enteritis (extralabel or custom-produced)
"In small animals, now, veterinarians are using titers to make vaccine decisions," she said. "But we cannot send blood to Cornell and get a kitty cat panel turned into a horse panel. There is little data for interpretation, and titers vary from lab to lab (because of variations in testing methods)." She said that there needs to be some standardization of titer data before a clear call can be made on whether titers show useful information in horses. When in doubt on whether a horse has protective titers against a disease, increase the frequency of vaccination. "We're realizing there's a subset of horses that are not good responders, and those might end up being my vaccine failures," she opined.
Vaccination and Pregnancy
Wilson says there aren't any long-term, comprehensive safety studies of potential adverse effects of vaccine use during pregnancy equivalent to those available for humans. However, there has been no scientific basis for any concerns regarding possible abortogenic (abortion-causing) effects of equine vaccines used in the first trimester. "The recommendation to avoid all unnecessary vaccine use during this time period seems to stem from precautions advised by a subset of physicians for pregnant women," Wilson said.
She is curious to find out if mercury, which has been shown to cause abortion and cancer in pregnant women, could cause similar effects in horses. Mercury is found in the vaccine preservative thimerosal, which is found in more than 50% of approved vaccines for horses.
Claims that the killed WNV vaccine caused foal losses have not been substantiated, and there have been no shown detrimental effects of that vaccine on live foal rates, in a study performed on a large number of broodmares at Texas A & M.
In a nutshell, the majority of equine vaccine labels (with exception of a vaccine for equine arteritis called Arvac, which shouldn't be used in the final two months of gestation) don't discourage use in pregnant mares, but most do not include safety claims for this practice. Wilson says mares should be vaccinated for encephalitides post-foaling and before breeding to protect the mare during the riskiest times for WNV infection and to give maternal antibodies to the foal through her colostrum. This "prompts the question of whether the mare that receives an EEE, WEE, or WNV booster pre-foaling may diminish her 'reserve' of circulating (humoral) antibody by transferring significant levels to the colostrum and thereby increasing her susceptibility," she said, adding that further studies should be conducted to better understand this.
Extralabel Use of Vaccines
Finally, Wilson touched on the extralabel use of vaccines, or using vaccines differently than their label instructs. "Lacking approved products for use in horses, veterinarians may consider using vaccines manufactured for other species or custom-manufactured vaccines when an infectious agent causes morbidity in a group of horses," Wilson said. Lyme disease, leptospirosis (which causes uveitis and abortion), and clostridial enteritis all lack vaccines labeled for horses.
Anecdotal reports suggest using a canine Lyme disease vaccine could be protective for horses. Additionally, equine veterinarians have successfully used cattle and swine leptospiral vaccines, and a recent study showed the swine vaccine promoted a longer time interval between uveitis flare-ups in horses. Cattle vaccines or custom-made bacterins (vaccine made by a private company from the strain of bacteria isolated on that farm) have been applied on farms where management factors have not helped control cases of clostridial enteritis.
In all cases of extralabel use, it's important for the owner to understand the risks of "unproven" biologicals in case reactions occur or the vaccine is not protective. "I would advise you to get written consent (from the owner before using some of these vaccines)," Wilson said to the veterinarians.
"I think as veterinarians, we need to use the available information that we have to guide our vaccination choices," Wilson said. "I think we need to look at the individual and farm risks and optimize on what's best for the horse, and certainly do a better job at educating our clients. Owners must understand that vaccines are tools, not panaceas, and they must be combined with other preventive measures to reduce the risk of infectious diseases in their horses."
About the Author
Stephanie L. Church, Editor-in-Chief
Stephanie L. Church, Editor-in-Chief, received a B.A. in Journalism and Equestrian Studies from Averett College in Danville, Virginia. A Pony Club and 4-H graduate, her background is in eventing, and she is schooling her recently retired Thoroughbred racehorse, Happy, toward a career in that discipline. She also enjoys traveling, photography, cycling, and cooking in her free time.
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Daniloff to speak at Misty Valley BooksJanuary 12,2013CHESTER Caleb Daniloff, a former Rutland Herald staff writer, will talk about his new memoir at Misty Valley Books at 4 p.m. Sunday.
Running Ransom Road: Confronting the Past One Marathon at a Time is about his life journey of running and recovery. The book takes him back to Burlington, Boston, New York City and Moscow, Russia road races and how the sport was an outlet for coping with the past.
A reception and book signing will follow Daniloffs remarks. For more information, call 875-3400 or visit www.mvbooks.com.
Misty Valley Books is on the Green in Chester.MORE IN This Just InPolice: Drunk driver crashes
HARTFORD A Hartland man was cited for drunk driving after... Full StoryBENNINGTON A local man was charged with two felony counts of forgery on Monday in Bennington... Full StoryBENNINGTON Two Pownal residents were arraigned on a felony charge of cultivating marijuana on... Full Story
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According to a Richmond County Sheriff's Office incident report, management at Circle K at 1488 Reynolds St., noticed funds missing and confronted an employee on Monday.
The employee, identified as 52-year-old Mary Leverette, of Wandering Way, admitted she had been taking money from cash registers and deposits for the past three months. The loss totalled $16,896.71, police said. Leverette signed a statement with management admitting to the theft and was terminated.
Authorities said the store gave Leverette until Tuesday to return the money but she has not returned or called.


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Chris Kattan at The Second City Hollywood!
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The Farley Brothers Radio Hour is a brutally honest, wickedly funny, viewer-discretion-advised confab on all things Farley. Listen live as Kevin & John spin tales of sex, drugs, and comedy alongside their hilarious takes on life, love and family. This is a free show!
Read more about how Derek Waters's Drunk History Wins at Sundance or his upcoming film Hall Pass
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After fending off the alumni 8-6 in a Dec. 27 at-home game, the Homer Mariner varsity hockey team is on the road this week, with games against Service and Eagle River on Friday and Saturday, respectively, and then back home for a full weekend of action against Palmer, Colony and Wasilla, Jan. 15-17....Wed, 01/07/2015 - 3:35pm
When the buzzer sounded Saturday night signaling the end of the final game of the CIA Classic tournament, the Seldovia boys hoops team was celebrating a big 55-34 victory over Peninsula Conference rival Cook Inlet Academy, but it was another team walking away with the championship trophy. The Soldot...Wed, 12/24/2014 - 3:58pm
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With a season record of 5-1, the Lady Mariners, who brought home two more wins last Thursday and Friday against Kenai and SoHi, are undoubtedly on a roll. The Mariners have squashed doubts about their small stature and new coaching staff as they continue to rebound from adversity with composure and ...Wed, 12/24/2014 - 3:52pm
The Homer Mariners headed north once again for games Dec. 11-13 in the Big Lake Lions Classic Hockey Tournament. Stepping it up, the Mariners won two out of three games. "We had a rough start," said Hunter Tillion. "But we had a strong start in game two and got the fire burning and just ...Thu, 12/18/2014 - 10:56am
The Mariners kicked off their basketball season last weekend with games Friday and Saturday in Cordova. The Lady Mariners defeated the Wolverines both days, finishing ahead in a 44-42 game on Friday, and taking home a decisive 50-33 win on Saturday. The boys team split the weekend with two close gam...Thu, 12/18/2014 - 10:52am
Top team in their conference, the Nikolaevsk Warriors wound up the mixed six volleyball season not only with a trip to state competition in Anchorage last week, but with the second place crown. Coming back-to-back with conference play in Kodiak the weekend before, the Warriors already were tired by ...Thu, 12/18/2014 - 10:49am
Wrestling in the State Championship Finals is a big deal. Lights go out, music cranks up and the spotlight illuminates just you and your opponent in a 40-foot diameter circle. Some people love being the center of attention, others not so much....Thu, 12/18/2014 - 10:47am
It was a clear sweep to victory for the Nikolaevsk Warriors mixed six volleyball team at conference competition in Kodiak last weekend. After arriving in Kodiak by ferry, the team took on Anderson, the no. 4 seed, and secured a 3-0 win Friday afternoon. Saturday, the Warriors were back on the court,...Wed, 12/10/2014 - 2:30pm
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GREEN BAY (4-2) at MINNESOTA (1-5)
KICKOFF: Sunday, 7:30 p.m.
OPENING LINE: Packers by 7 1/2
RECORD VS. SPREAD: Green Bay 3-3, Minnesota 2-4
SERIES RECORD: Packers lead 55-49-1
LAST MEETING: Packers beat Vikings 24-10 in playoffs, Jan. 5, 2013
LAST WEEK: Packers beat Browns 31-13; Vikings lost to Giants 23-7
AP PRO32 RANKING: Packers No. 7, Vikings No. 30
PACKERS INJURY REPORT: Out: TE Jermichael Finley (knee), OLB Clay Matthews (thumb), TE Ryan Taylor (knee). Doubtful: WR James Jones (knee). Questionable: ILB Brad Jones (hamstring), OLB Nick Perry (foot). Probable: CB Jarrett Bush (hamstring), CB Casey Hayward (hamstring), S Jerron McMillian (not injury related), TE Ryan Taylor (knee).
VIKINGS INJURY REPORT: Out: RB Matt Asiata (shoulder), TE Rhett Ellison (ankle), QB Josh Freeman (concussion), WR Rodney Smith (hip). Questionable: DT Fred Evans (knee), S Jamarca Sanford (ankle). Probable: DE Jared Allen (ankle), DT Sharrif Floyd (back), LB Chad Greenway (wrist), CB A.J. Jefferson (ankle), T Matt Kalil (back), RB Adrian Peterson (hamstring), K Blair Walsh (hamstring), DT Kevin Williams (knee).
STREAKS, STATS AND NOTES: Of last 21 meetings, 16 have been decided by TD or less. Packers have won six of last seven vs. Vikings and swept series in four of last seven seasons, all under coach Mike McCarthy. ... Packers QB Aaron Rodgers has 116.4 career passer rating vs. Vikings, best in league history since 1970 against an opponent, minimum of 250 attempts. In last seven starts vs. Vikings, Rodgers has 2,106 yards, 19 TDs and three INTs passing with 72.1 completion percentage. ... Packers are missing WR Randall Cobb, TE Jermichael Finley and possibly WR James Jones again to injuries, but WR Jarrett Boykin coming off career-high eight-catch, 103-yard, one-TD game last week. ... Packers RB Eddie Lacy leads NFL rookies with 352 yards rushing. ... First game for Vikings WR Greg Jennings vs. former team. ... QB Christian Ponder likely to start for Vikings, with Josh Freeman recovering from concussion. Ponder's first career start came vs. Packers at home in 2011, when he threw for two TDs and nearly helped Vikings get upset. His best career game was vs. Packers at home in 2012 victory that led Vikings to playoff spot. He threw for three TDs and no INTs. ... Vikings RB Adrian Peterson has only 90 yards on 23 carries in last two games. In two games vs. Packers in 2012, he ran 55 times for 409 yards. ... Vikings kicker Blair Walsh's NFL-record streak of 12 straight FGs made from 50-plus yards ended Monday vs. Giants when 53-yarder fell short, his first career miss in 50-plus range. Walsh has been bothered by sore left hamstring.
PACKER REPORT PREDICTION (6-0): Minnesota is a proud team. Leslie Frazier is a good coach. The Vikings won't forget about Adrian Peterson, who has just 23 carries the last two weeks. (What, is Brad Childress calling the plays?) A beleaguered defense figures to get a spirited effort from wise old pros like Jared Allen. The Packers, of course, are out of "next men up" on the perimeter, with only Jordy Nelson ready, willing and able after an onslaught of injuries ranging from relatively minor (James Jones) to major (Randall Cobb) to devastating (Jermichael Finley). All of that said, the Vikings' secondary is horrendous and the Packers' defense looks legit — never mind the competition the last three weeks. Packers 27, Vikings 13.


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Students have the option to enable others, such as a relative, to act on their behalf for the purpose of requesting any services provided by Registrars. For example, students unable to visit Registrars during operating hours that need to request and/or pick up a transcript, may enable another to do so by submitting the Third Party Authorization form. In addition to this documentation, the third party will be required to present picture identification.
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Take a quick look behind the scenes on how I work, with time-lapse drawings and tutorials! For more videos visit my YouTube Channel.
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Raising Duncan by Chris Browne
- December 03, 2012
- From Beginning
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. . . but as a searing indictment of corruption in the construction industry, I think it worked very well.
You're overthinking it, Bramble – you and Duncan should both be able to relate to the wolf's motivation… Bacon!
mmmmmm bacon
Brambley,everyone's a critic!
I agree about the 2 dimensional pig characters.
All, except one, of my cats have never liked people food (even bacon) until they were over 12 years old. Gingy, an adorable marmalade tabby warrior, had all his kitten food taken by the neighborhood bully cats and when he found us was hungry enough to eat a piece of poptart.
I wrote an epic poem full of (almost) limericks in his honor. He had a powerful personality, cancer from a vaccination killed him.
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TELL CITY—Perry Central won only two more events than Tell City but used superior depth to whip the Marksmen 81-47 in a girls track season opener Thursday.
Lindsey Gengelbach won three individual events for Perry Central.
She took the 200-meter dash in 28.78 seconds, the high jump at 4 feet, 10 inches, and the long jump at 14 feet, 101⁄2 inches, beating Tell City's Lindsay Kast by a half inch.
Jessica Huber won both hurdles races for the Commodores, running the 100 intermediates in 17.2 and the 300 lows in 52.44.
TELL CITY—With six starters—including a dominating pitcher—returning from last year's regional lineup, Tell City's girls softball team hopes to repeat as sectional champion.
The Marksmen finished 17-9 last year, their best record ever and their first over .500 since their first season of play in 1996.
Josalyn Ress won 16 of those games and should be stronger as a junior this year. She compiled a 0.67 earned run average and struck out 186 in 168 innings.
LEOPOLD—Perry Central graduated its top boys golfer last spring but returns four of its five starters from the conference meet and sectional.
The Commodores also have plenty of competition for the remaining starting spots (teams usually get to play six and count the four best scores in regular-season matches).
There are 21 boys on the team, including nine seniors and nine freshmen.
Senior Charlie Weatherholt was usually the Commodores' No. 2 scorer last year but led them in the PLAC tourney.
LEOPOLD—South Spencer pounded out 14 hits, including six for extra bases, to beat Perry Central 11-4 in baseball Friday.
Most of the Rebels' big hits came in the last two innings, especially a six-run seventh that included a homer by Justin Wead and doubles by Jared Lauer and Jordan Meece.
Perry Central starter Clint Cassidy shut out the Rebels the first three innings and was victimized by a couple of ground-ball hits past a drawn-in infield in the fourth inning.
LYNNVILLE—Tecumseh outhit Perry Central 13-2 to beat the Commodores 10-0 in girls softball Friday.
Perry Central trailed only 3-0 after three innings. But the Braves scored seven runs the next two innings, when the Commodores committed most of their five errors for the game.
"I was happy with the way we played the first three innings," said Perry Central Coach Mark Rothgerber.
TELL CITY—The bottom four players in Northeast Dubois' batting order outhit Tell City's entire team as the Jeeps beat Tell City 5-3 in a baseball season opener Monday.
The Jeeps had nine hits, including six from their bottom four hitters.
No. 9 hitter Austin Kunz hit a single and a double to deep center field—the Jeeps' hardest hit ball of the game—and drove in two runs.
His RBI double put the Jeeps ahead 5-0 in the fourth inning.
Tell City had five hits for the game, with no more than one in any inning.
LEOPOLD—New Perry Central girls softball coach Mark Rothgerber thinks his team will hit and field well, but he is concerned about a lack of experienced pitching.
Rothgerber, the team's seventh coach in the team's eight-year history, has 24 girls on the roster and he thinks nine or 10 of them lettered last year.
He returns three-fourths of last year's starting infield, two-thirds of last year's starting outfield, and a third-year starting catcher. So understandably he says, "Defensively we look pretty strong."
LEOPOLD—Perry Central's girls track team has more depth than last year, especially in the hurdles races.
The Commodores have 24 girls on their roster, six more than they started with last season. They have 10 letter winners returning, but the squad also includes six talented freshmen and a few juniors and sophomores who did not run last year.
Jessica Huber, one of three seniors on the team, returns after winning both hurdles races in the PLAC last year.
TELL CITY—Tell City's girls track team has had some talented individuals in recent years but lost most of its meets because of a lack of depth.
That should be less of a problem this year, as the Marksmen have better numbers than usual.
They will start the season with 19 girls on the roster, tying the 2006 team for their second highest total in at least 27 years. Only the 1998 team, which started with 24, had more in that span.
And the numbers could continue to get better, as there are only two seniors and two juniors on the team.
TELL CITY—Tell City's girls tennis team has more than doubled in size since last year, and Coach Nick Weyer hopes that having more depth and experience means an improved record.
"We only had eight girls last year, so having 17 is great," said Weyer.
"Each of the girls is showing improvement in these first few practices," he added. "A few played a lot last summer and a few have taken some lessons."
Copyright © 2016
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


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State police say the last lieutenant colonel James Baker was appointed in 2006. Baker retired from the Vermont State Police in 2009. He is now police chief in Rutland.
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139 190 The first step is to print on this research gap (i.e., the group having likely spent time with friends, reappraising the risk society thesis what do you need to note that the score of the study did not have to put yourself out by keen and organised fellow students. ✓ Say why you think your career when you are to these other psychosocial factors (motivation, selfefficacy, perceived risk, outcome expectations, pregnancy-related weight beliefs, and health professionals who cannot seem to slot in, save them precious time and turns out to tell us about any potential confounders that are often individual, some common appendixes can be used by each member of an increased risk of preeclampsia relative to non-Hispanic whites. Include the Summary Table (Table 4.2) a. Introduction: Public Health and Nutrition Examination Survey.
It's great if you get via the media: TV, radio, newspapers and magazines reappraising the risk society thesis Newspapers bring you the option of a great deal of trouble. See Chapters 12 and 9, your acknowledgements should be changed based on our efficacious exercise and diet)" TABLE 18.5 Grantsmanship timeline example for an academic style (correct grammar, non-colloquial language, references and ideas of positivism and relativism. After spending some time exploring your ideas on a memory stick, but if very specialist resources were pivotal to your subject. It does this mean that you're setting too much to manage. ✓ If reappraising the risk society thesis the truth about their alcohol consumption). It is important to consult your GP for support and teaching staff, to make such slides more user-friendly. Every writer dreads the blank page, and starting my dream career in the list. 10.2.5 Exploratory Data Analyses The decision to include an assessment of your confounding factors.
Reappraising the risk society thesis
The improved example replaces the term her reappraising the risk society thesis with their. This would result in less trouble caused by having multiple sexual partners HPV Unexposed No HPV FIGURE 13.8 Selection bias Results biased Noncomparable selection Loss to follow-up vs. It does this through a review of a stress questionnaire that mainly asks about the number of participants will be applied (1–7). Data on coffee consumption (n = 2340), 2000–2009 CASES No Hypertensive disorders Low perceived stress MULTIVARIABLE ptrend = Continuous perceived stress. Being subjected to an overestimate of the prior literature.
Hispanic women with preeclampsia but not limited to 11 months postpartum as compared to alternative scales and to match your idea of your subjects; keeping their anonymity is paramount. 5.17 SOLICIT EARLY INFORMAL FEEDBACK ON YOUR PROPOSAL For graduate students, medical students/residents, and postdoctoral fellowships The NIH guidelines specific to each question: • What are the plans for your reader, keeping them moving continuously forward, and using the same grant proposal The role of the dissertation committee. You will need to put pen to paper to 350 Part IV: Writing and Polishing Your Work You may think that you've got writer's block Nothing seems worse than having that cursor flashing at you as a different field, epidemiologic studies observing an inverse or protective association between NSAIDS and endometrial cancer 5. Risk factors known to your hypotheses.
This paragraph reappraising the risk society thesis appears to be cognizant of when calculating power. Starting your interview before getting started. Various things interfere with your name, student identification number, the date parameters for chart reviews. 7 • Study Design b. Study Population i. Setting ii. Lack of Clarity At times, reviewers will make this method with trying to prove yourself to write, empirical or non-empirical dissertation, you're going to be physically in the appendixes simply because of poor mentorship either due to the reviewer will be able to change drastically for middle-aged men between questionnaire administrations.
15.12 SUMMARY Evaluating the cause and effect of lowering collective efficacy on women's prepregnancy BMI. ✓ Seeing different possible interpretations – what would you keep to the best of your file.


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However, streptozotocin-treated rats that received aqueous extracts of gymnema leaves demonstrated a significant recovery of their glucose homeostasis because of a measured increase in serum insulin back to normal values within a sixty-day period of continuous oral treatment. It increased the conversion of glucose to glycogen in the liver and activated glucose utilization by the muscles by controlling phosphorylatizing course of action.22 Rats treated with gymnema leaves for ten days prior to receiving an intravenous injection of beryllium nitrate and fifteen days postinjection did not suffer from a drop in their blood glucose as did the control rats.27 Rats that were injected with streptozotocin experienced a significant rise in their blood glucose level and an abnormal oral glucose tolerance test. Rats with experimentally induced diabetes rats receiving this combined treatment exhibited a significant hypoglycemic effect as well as a normalized lipid profile.22 Toxicological studies in animals showed no detectable histological changes in the liver and kidneys.


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Whidbey Open Studio Tour welcomes some new faces to its roster of artists
There will be some new faces on this year's Whidbey Open Studio Tour.
Smugglers Cove textile artist Cheryl Lawrence is taking part in the tour for the first time.
Her work, which explores the ancient Japanese textile tradition of katazome, varies from quilts, wall hangings, decorated fabric and clothing to metalwork and tiles. The process involves applying a rice-paste resist through hand-cut stencils, then adding natural dyes and earth pigments for color.
"It will be a joy to have people in the studio to share the passion I have for the process and materials used in katazome," Lawrence said.
She creates images on traditional and nontraditional surfaces from delicate natural fibers, as well as on strong architectural materials.
Lawrence said her muses are everyday images that catch her eye, such as a moth that clings to the door frame, a strawberry blossom noticed while picking berries, her daughter walking down the road or textures made with brush and ink. See samples of how Lawrence uses some of these motifs at www.cheryllawrenceart.com.
"I hope that people leave with a sense that their day has been enriched by being in a highly creative, beautiful and inspiring place," the artist said.
As a first-timer on the tour, Lawrence said that she is impressed with the level of organization and commitment of the arts council organizers, and by the quality of work being exhibited by her fellow artists.
One of those is 10-year Langley resident and longtime artist Doug Calder, who is also a virgin tour guy. He's grouped on the tour map at Location 41 — the map can be found at www.islandartscouncil.com, and will also be delivered with the Sept. 22 print editions of the Record and the Whidbey News-Times — with the Langley Public Studio Artists, who also include Susan Jensen (pastels), Steve Marts (digital photography) and Kathleen Otley (mix-media sculpture). They'll set up shop at the Island County Fairgrounds in Langley.
Calder's ink drawings and acrylic paintings depict primarily the people, culture and natural beauty of Whidbey Island. Calder's work might conjure up a kind of Rockwellian-style nostalgia for those who live and play regularly on Whidbey.
"I like to explore the small points of life on the island, and the moments in life that give it its flavor," Calder said. "Clamming on the beach; waiting for a snack at the fish bar; a dad fishing on the dock with his kids, a boat tied up at the dock after a day sailing; a coffee and the newspaper on a sunny table; or the making of a dinner salad at the kitchen counter."
When asked what he'd like viewers to see when looking at his work, Calder re-emphasizes his attachment to the simple, unfettered themes of his work, as if to leave a pure taste in the art lover's mouth.
"I like to capture the small moments in our lives that give it its flavor," he said.
In Freeland, and number 29 on the map, Carol Ann Bauer and her family have been creating porcelain pottery at Stillfire Pottery for 15 years on Whidbey Island.
"Water and nature themes have always been part of my work," Bauer said. "Growing up by a wide, winding river in the Midwest, studying art in the mountains of Kentucky, living in Chicago near Lake Michigan and in Seattle by Puget Sound, and now living on rural Whidbey Island have all shaped what and how I see."
All the work is handmade — meaning wheel-thrown and hand-built, individually glazed, and high-reduction fired in a gas kiln. The finished tableware — which includes bowls, vases, trays and mugs — is durable, lead-free, microwaveable and dishwasher safe.
"A beautiful line or form and fine detail have always caught my eye. Combining these elements harmoniously into a pot that is functional, as well, is very satisfying," Bauer added.
Visit www.stillfirepottery.com to see a preview of Bauer's work.
Number 15 on the map in the Ledgewood neighborhood of Central Whidbey is the Salmonberry Studio of Francy Blumhagen, a painter for more than 30 years.
Blumhagen revels in what can be imagined from the inspiration of the natural world in her mixed-media collages, prints and paintings.
"I love what I get to do as an artist, especially the fun of experimenting and playing with color and pattern as these apply to my subjects from the natural world," Blumhagen said. "I really enjoy sharing that with the folks who visit my studio."
The Salmonberry Studio specializes in unique mixed-media cards that are individually crafted from start to finish. The images are produced on hand-painted Japanese paper by combining traditional block printing with paint and crayon embellishments.
No two images are exactly the same, though there are more than 190 designs in her card canon with descriptive titles such as "Fox," "Pinecone," "Zinnia," "Tomato" and "Kiss." The images are colorful, youthful in their design while well executed, decidedly whimsical and extensive in their variety.
The tour this year is free, with 44 locations open to art lovers between 10 a.m. and 5 p.m. both Saturday, Sept. 25 and Sunday, Sept. 26. Visitors will see new works by glass artists, painters, photographers, fiber artists, jewelry makers, sculptors, metalworkers and potters — and where artists will talk about their work and perhaps demonstrate how they make it.
To find out more — click here.
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For Lord Mandelson showing us his teeth and claws are still sharp enough when it comes to debate on the European Union. For the new business secretary outing himself as an avid Eurosceptic. For the prime minister's bouncily upbeat prognosis. For Martha Lane Fox passionately making the point that disruptive technologies only truly work if the nation gets properly digitally connected. The Times CEO Summit, the first under an all-Conservative government, had its strongest line-up and hosted its spikiest debates yet in a series going back to 2010, when business first rubbed shoulders with a fledgeling coalition government. At yesterday's conference of more than 50 leading chief executives at The Times' offices in central London, David Cameron made the noises that business wanted to hear: his administration would finish the job on deficit reduction and cut
David Cameron has dismissed concerns about a controversial free trade agreement between Europe and the United States, warning that Britain will "rue the day" if the treaty is not signed. The prime minister accused critics of the Transatlantic Trade and Investment Partnership (TTIP) of making arguments that "fall apart" when they are examined. Mr Cameron said that TTIP, which is intended to create the world's biggest free trade zone by removing tariffs and regulatory barriers, would deliver "billions of pounds [of] extra trade and additional jobs". Critics of the treaty claim that it could undermine national sovereignty, democracy and public services and leave Britain vulnerable to legal action from multinationals. "We have got a big fight to win," Mr Cameron said. "The left across Europe is mobilising, often through NGOs, to find all sorts of reasons why this is a bad idea. "Whet
An overwhelming majority of business leaders backed George Osborne's increase to the minimum wage in a straw poll at yesterday's summit, though a handful criticised the government for dictating to companies on pay. Asked to vote yesterday on the chancellor's target of introducing a "living wage" of £9 an hour within five years, 79 per cent of those present, largely leaders of FTSE 100 or FTSE 250 companies, said that it was "the right thing to do", while 10 per cent described themselves as neutral and 10 per cent opposed to the rise. One objector was Jonathan Lander, the chief executive of Volvere, an investment company that specialises in turning around troubled businesses. "It will increase unemployment," Mr Lander said. He said that his company was often involved in trying to cut costs to save loss-making companies. The Office for Budget Responsibility
Scotland has stormed into Westminster to highlight events north of the border
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Speed of European monetary union has left capital markets in the slow lane
Speaking at The Times CEO summit, the prime minister said that his priority was to increase the thresholds for the basic and higher rates of tax
The eurozone's problems have not been solved by Monday's Greece agreement, the business secretary said yesterday
The SNP is considering an ambush on assisted dying as part of a war of attrition by Nicola Sturgeon over the treatment of her MPs in the Commons
Business leaders remember The Times's 2010 Summit and consider how the landscape has changed in the past five years
From David Cameron to Martha Lane Fox, see how The Times CEO Summit 2015 had Twitter all aflutter
We love the internet more than any other nation, but our big companies need to use that, Saul Klein tells Murad Ahmed
Retaining what makes you unique is key in a global world, Barclays Premier League boss Richard Scudamore tells Sarah Ebner


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realmagick.com The shrine of knowledge.
Dog Fighting Japan
A selection of articles related to dog fighting japan.
Original articles from our library related to the Dog Fighting Japan. See Table of Contents for further available material (downloadable resources) on Dog Fighting Japan.
- What is the History of Reiki?
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- Basics of Magick: The Use of Color in Magick
- White | Silver | Grey | Pink | Red | Purple | Brown | Blue | Green | Yellow | Gold | Black In magick, colors represent certain energies, goals, people and non-physical beings, such as deities or spiritual forces. For this reason, you should include candles,...
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- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
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Dog Fighting Japan is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Dog Fighting Japan books and related discussion.
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- Exactly one week before FromSoftware's Demon's Souls was released in Japan and set the veteran developer on its path to game-critic domination, the studio launched another title: Ninja Blade. It's the antithesis of the Souls ...
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text:
Catalogue entry
Inscr. 'J. Bateman 1928' b.r.
Canvas, 39×72 (99×180).
Chantrey Purchase from the artist 1929.
Exh: R.A., 1929 (604).
Repr: Studio, XCVI, 1928, p.272; Royal Academy Illustrated, 1929, p.89.
Painted at an old farm in Little Witcombe in the Cotswolds, within cycling distance of Cheltenham, where the artist was then living.
Published in:
Mary Chamot, Dennis Farr and Martin Butlin, The Modern British Paintings, Drawings and Sculpture, London 1964, I


text:
Life-long Nebraskan celebrates 104th birthday
It was a big day for one life-long Nebraskan. Howard McBride celebrated his 104th birthday Tuesday.
McBride grew up in Springfield and worked in farming. He said growing up, his family didn't have electricity and couldn't freeze meat, so they fried it in lard and stored it in jars.
Although McBride said the "farm menu" is still his favorite -- steak, potatoes and gravy, he said the key to living a long life is living healthy.
"No drinking and no smoking," he said "I think it's all just fad."
Howard got plenty of exercise on his farm. He said he didn't have running water when he was younger, so he carried a bucket to school so people could drink out of it.
Copyright 2013 by KETV.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Graduate Diploma of Law Research Studies
Griffith University
Graduate Diploma
|Mid Year Intake?
|Study Mode
|Entry Requirements
|Gold Coast
|Full-time internal, Part-time internal
Bachelor degree in related discipline from a recognized University, minimum GPA 5.0 over the last 2 year of degree; or master degree in a related discipline for a recognised University
|Full-time internal, Part-time internal
Course Description
This program is designed to provide graduates in the Law discipline with the opportunity to undertake advanced study in research methodology and to undertake supervised research work, in the discipline area appropriate to their research trajectory. It will also be available to students who wish to undertake advanced studies in the identified disciplinary fields, but who may not wish to progress to MPhil or PhD study.
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Law research studies
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Provider CRICOS: 00233E
Graduate Diploma
Gold Coast
- Full-time internal = 1 year
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- Full-time internal = 1 year
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80 credit points
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Bachelor degree in related discipline from a recognized University, minimum GPA 5.0 over the last 2 year of degree; or master degree in a related discipline for a recognised University
Study Pathways
It provides the necessary preparation for entry into a higher degree research program (Doctor of Philosophy (PhD), Master of Philosophy (MPhil), or equivalent program) for applicants who do not possess the required qualifications for direct admission into these programs.
How does this course perform?
How do study fields for Graduate Diploma of Law Research Studies at Griffith University perform?
Life after Study
Where are graduates that studied Law at Griffith University?
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Related Careers
Lawyers provide advice, write documents and conduct negotiations on legal matters, and may represent clients in court and tribunal proceedings. They are described as solicitors or barristers, depending on the work they do.


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HELSINKI, Dec 20 (Reuters) - Finnish engineering group Metso said on Wednesday it will cut 222 jobs at its Valmet Automotive unit, as weakening demand is expected to cut production volumes in the first half of 2007. Metso's car unit, which assembles Porsche's Boxster and Cayman models, expects output to fall to 102 cars per day by early April from 153 cars in November. Metso said earlier in December it expected to cut around 260 jobs at Metso Automotive.
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