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Patent application title: ANTIMICROBIAL COMPOSITION AND METHODS AND APPARATUS FOR USE THEREOF
Jose Barreto (North Fort Myers, FL, US)
IPC8 Class: AA01N3100FI
USPC Class:
Class name: Drug, bio-affecting and body treating compositions inorganic active ingredient containing ammonia or ammonium compound containing
Publication date: 2011-01-13
Patent application number: 20110008469
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There is presented an alkaline disinfectant in the form of a
multi-component composition, with each component being relatively benign
until mixed with the other components in a ready-to-use solution. The
invention further relates to the use of the composition in a variety of
applications and apparatus for mixing and dispensing thereof.
Furthermore, the invention relates to the use of components that
synergistically provide effective biocidal activity in a broad spectrum
of organisms, including germs, molds, viruses, bacteria, bacteria spores,
or other microbes or pathogens. The composition provides a chemical
system that kills all known plants, animals and microbes by raising pH
and rapidly, but indirectly, transporting hydroxide into cells by use of
ammonia compounds and/or amine compounds as neutral transporters. The
composition components synergistically operate together to provide a
disinfecting/cleaning composition useful for many different applications.
1. A biocidal composition comprising:an amount of at least one first
component designed to suppress ionization and generate a permeable
hydroxophore in a solution of components in the composition,an amount of
at least one second component designed to accelerate the net transfer of
hydroxide ions across the organism plasma membrane of the microbe or
pathogen,an amount of at least one third component designed to disrupt
cell membranes and invert a membrane potential,wherein at least one of
the components causes fluidization of a cell membrane of a microbe or
pathogen,wherein the at least three components, when combined with an
external alkaline pH gradient, generate an alkaline flux which leads to
cell death by rapidly raising the pH of the cellular cytoplasm.
2. The composition of claim 1, wherein the killing mechanisms of the composition are selectively switched off by neutralization.
3. The composition of claim 1, wherein the composition leaves little to no residual toxicity upon neutralization of the composition.
4. The composition of claim 3, wherein neutralization occurs by evaporation of one of more of the components or by the application of a neutralizing agent.
5. The composition of claim 1, wherein the at least one first component is a long chain detergent material in a concentration of mM range.
6. The composition of claim 1, wherein the at least one second component is a hydroxophore material in a concentration of mM range.
7. The composition of claim 1, wherein the at least one third component is an alcohol in a concentration of mM range.
8. The composition of claim 1, wherein the concentration of the at least one first component is in the range of about 5-40 weight percent relative to the at least three components in the composition, the at least one second component is in the range of about 5-40 weight percent relative to the at least three components in the composition, and the at least one third component is in the range of about 1-10 weight percent relative to the at least three components in the composition.
9. A process for preparing a biocidal composition, the process comprising:providing an amount of at least one first component designed to suppress ionization of components in the composition, an amount of at least one second component designed to create an alkaline environment of non-ionized constituents around the cell membrane of the microbe or pathogen, and an amount of at least one third component designed to reverse the cell membrane potential, with each of the components stored separately, andmixing of the components for deployment to decontaminate surfaces or areas.
10. The process of claim 9, wherein the at least one first component is a long chain detergent material in a concentration of mM range.
11. The process of claim 10, wherein the at least the at least one first component is a long chain detergent.
12. The process of claim 9, wherein the at least one second component is a hydroxophore material in a concentration of mM range.
13. The process of claim 9, wherein the at least one third component is an alcohol in a concentration of mM range.
14. A biocidal composition comprising:at least an amount of a first component being a detergent material in a concentration of mM range,at least an amount of a second component being a hydroxophore material in a concentration of mM range,at least an amount of a third component being an alcohol in a concentration of mM range,wherein the at least three components, when combined with an external alkaline pH gradient, act as a biocidal agent.
15. The composition of claim 14, wherein the first component is a long chain detergent material.
16. The composition of claim 14, wherein the killing mechanisms of the composition are selectively switched off by neutralization.
17. The composition of claim 16, wherein neutralization occurs by evaporation of one of more of the components or by the application of a neutralizing agent.
18. The composition of claim 16, wherein the composition leaves little to no residual toxicity upon neutralization of the composition.
19. The composition of claim 14, wherein the detergent material is selected from the group consisting of ammonia, cetyl trimetylammonium chloride, cetyl trimethylammonium bromide, tetradecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium bromide, sodium dodecyl sulfate, sodium tetradecyl sulfate, sodium cetyl sulfate, sodium octyl sulfate, hexadecylamine, tetradecylamine, 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate, 3-(decyldimethyl-ammonio) propane sulfonate or combinations thereof.
20. The composition of claim 14, wherein the alcohol is selected from the group consisting of methanol, ethanol, propanol, butanol, benzyl alcohol or combinations thereof.
[0001]This patent application claims the benefit of U.S. Provisional Patent Application No. 61/224,308 filed Jul. 9, 2009, the disclosure of which is expressly incorporated by reference herein.
[0003]The invention relates to antimicrobial compositions and methods and apparatus for effective use thereof. More particularly, the invention relates to antimicrobial compositions useful for a variety of purposes in cleaning and disinfection, and methods and apparatus for using and dispensing the compositions.
[0004]Antimicrobials are generally used to destroy or suppress the growth or reproduction of microbes such as bacteria, viruses and the like. Many commonly available germicides are too toxic, excessively persistent, or difficult to handle in certain applications. For example, germicides using ozone, bleach, ethylene oxide, and various other oxidizing or halogenating chemicals fit in this category. Such germicides use a harsh chemical toxicity to engender killing but, whenever biocides are used, a balance must be struck between reducing an infectious microbial hazard and the creation of a serious chemical hazard. Antimicrobial compounds may act on targeted microbes in a variety of ways. For example, the antimicrobial compound may alter the cell wall of a microbe, either by altering cell wall permeability or by altering cell wall synthesis and repair, to destroy the microbe. Other compounds may prevent DNA or protein synthesis to destroy the microbe. While there are numerous known antimicrobial compounds, and numerous known mechanisms by which antimicrobial compounds may function, such compounds have various deficiencies. There are many characteristics that can be relevant when trying to decide whether or not a particular compound is useful as an antimicrobial. Relevant factors may include the relative potency of the compound against a specific microbe or against a spectrum of microbes, and the relative selectivity of the antimicrobial activity of the compound in targeting microbes or pathogens. Other factors may relate to the compounds producing undue irritation to eyes or skin at levels required to impart germicidal properties. Some antimicrobial compounds can be dangerous to use at higher concentration levels, or may leave residues that can continue to cause physical implications in humans. There are also long-term concerns, including the likelihood that the microbe may develop resistance to the antimicrobial compound. Additionally, additional concerns may relate to the cost and commercial availability of the antimicrobial compound.
[0005]Disinfecting compositions are commercially important products and enjoy a wide field of utility in assisting in the disinfecting and cleaning of surfaces, such as for use in cleaning "hard surfaces". Hard surfaces are countertops, walls, floors and other such surfaces, such as in the home in kitchens, bathrooms, etc, and in hospitals or the like, where cleaning and disinfecting of such surfaces is important. Various formulations of cleaning/disinfecting agents have been developed, but may not be as effective at disinfecting and cleaning as desired. There is thus a current and continuing need for cleaning/disinfecting products which are highly effective disinfectants, but leave a minimum of discernible residue and are easily used and produced inexpensively.
[0006]In some applications, the materials used in cleaning or purifying materials may have other deficiencies. In water treatment for example, compounds such as chlorine are commonly used, but are toxic, and therefore may cause potential problems. For example, chlorination for the disinfection of raw water may produce trihalomethanes (THM's), such as chloroform, which are carcinogenic. It has further been determined that chlorinated drinking water, when ingested by laboratory animals, has also shown signs of carcinogenic effects. Handling of the material is also hazardous, putting those working with it at risk. Other water treatment approaches are costly or less effective than desired.
[0007]Currently, there are also heightened concerns over the hazards produced by microbes and pathogens, including in relation to the potential of bioweapons engineering of microbes or pathogens that could be released to impact a population. Other concerns relate to the possible release of biohazardous materials by accident. Government entities have therefore begun steps of preparedness for handling such incidents should they arise. Sterilization after a biological weapon attack is problematic when using overly harsh sterilizing agents. Although such germicides will destroy pathogens, they also damage the environment, and can result in damage to sensitive electronic equipment, furnishings and documents, can corrode metals, and harm human health. As a consequence, most germicides have a narrow scope of use and/or require extensive training for safe deployment.
[0008]Accordingly, new antimicrobials and germicides, and new sources of antimicrobials are desired and are increasingly valuable. It would also be highly desirable to provide antimicrobial compositions that achieve the characteristics of providing broad spectrum antimicrobial activity, while minimizing eye or skin irritation or other harmful effects, and while providing desired cleaning efficacy.
[0009]In general, this invention relates to an alkaline disinfectant in the form of a multi-component composition, with each component being relatively benign until mixed with the other components in a ready-to-use solution. The invention further relates to the use of the composition in a variety of applications and apparatus for mixing and dispensing thereof. Furthermore, the invention relates to the use of components that synergistically provide effective biocidal activity in a broad spectrum of organisms, including germs, molds, viruses, bacteria, bacteria spores, or other microbes or pathogens. The composition provides a chemical system that kills all known plants, animals and microbes by raising pH and rapidly, but indirectly, transporting hydroxide into cells by use of ammonia compounds and/or amine compounds as neutral transporters. The composition components synergistically operate together to provide a disinfecting/cleaning composition useful for many different applications. In an example, the composition comprises 1) ethanol, 2) cetylamine, 3) ammonia and 4) a pH greater than 9.
[0010]The germicide according to the invention has the following characteristics. Extreme lethality, with no pathogens remaining to cause infection. A broad spectrum of killing activity is provided, with rapid killing of pathogens. The germicide has a short persistence time, with no long term toxicity remaining, and also has "switchability, wherein chemical neutralization may be used as a switch to immediately deactivate the germicide. Further, as components have high vapor pressures, evaporation of several components after deployment of the biocide provides an "auto-switch", so that after sterilization, no long term toxicity can occur. The germicide also is inexpensive, portable, storable, safe and easy to use. The germicide and methods and apparatus for dispensing provide a system, wherein multiple components are safely provided in a storable arrangement, and easily mixed and used to provide for extreme lethality of microbes and pathogens. In an example, a dispensing device design allows the components to be stored safely for long periods in a multi-compartment plastic cylinder. When use is desired, mechanical rupture of plastic membranes is followed by mixing to obtain the germicidal composition and activity. A method for the cleaning of hard surfaces comprises the steps of providing the components for preparing a germicidal composition as described above; selectively mixing the components just before deployment, diluting the mixed composition with up to about 500 parts by weight water; and contacting the diluted cleaning composition with a hard surface to thereby kill microbes or pathogens that may be on the surface.
[0011]It is therefore an object of the invention to provide a germicidal disinfectant which conforms to these requirements, which can be formulated as a storable concentrate, and can be selectively diluted to form an aqueous, ready-to-use solution. The invention includes both methods and compositions to achieve the desired results, as described, but is not limited to the various embodiments disclosed.
[0012]FIG. 1 is a graph representing the effects of ethanol in differing concentrations on test bed organisms;
[0013]FIG. 2 is a graph representing the effects of hexadecylamine in differing concentrations on test bed organisms;
[0014]FIG. 3 is a graph representing the effects of ammonia in differing concentrations on test bed organisms;
[0015]FIG. 4 is a graph representing the effects of differing pH on test bed organisms; and
[0016]FIG. 5 is a graph representing the killing efficacy of the composition according to an example of the invention and other killing agents.
[0017]FIG. 6 is a graph representing the killing efficacy of a composition according to an example of the invention with varying detergent materials.
[0018]FIG. 7 is a graph representing the killing efficacy of a composition according to an example of the invention with varying alcohol materials.
[0019]Turning to a first example according to the invention, the composition of the germicide comprises a synergistic combination of components that together utilize an inward flux of chemicals that immediately interferes with cell metabolism and viability. The composition uses multiple components and multiple mechanisms to achieve complete lethality of microbes and pathogens of various types, such as including germs, molds, viruses, bacteria, bacteria spores, or other microbes or pathogens. The composition generates chemical flux into such microbes and pathogens that is invariably lethal to the microbes and pathogens. Although there may be extremophile organisms, occupying certain rare environments on earth, are capable of resisting the killing mechanism engendered by the composition of the invention, these are not human pathogens. Further, by using longer, or more concentrated treatment, even these extremophiles can be effectively killed by the germicide.
[0020]In general, the germicidal composition of the invention is alkaline, and has at least three components which act synergistically to kill germs, microbes and pathogens, and the mechanism of action is generic and can kill various microbes and pathogens including bacteria, bacterial spores, molds, and viruses for example. As with other components as will be described, each is in very small concentrations in the mM range. The first component is a small amount of ammonia or another long chain detergent type material for example, in the mM range, and in an amount of between 5-40 weight percent for example relative to the other components. Other concentrations may be suitable depending on the application. In this example, ammonia can exist in two forms in water, free base ammonia (a gas solvated in liquid water; NH3) and a protonated form, the ammonium ion (NH4.sup.+). The free base ammonia (NH3) is readily permeable through the plasma membrane of all living cells and the free base form is more prevalent above the pKa of 9.0. That is to say, above a pH of ˜9.0 the free base will predominate. If the external pH of a cell is raised above 9.0 (and maintained at that pH) the cell will eventually die because an alkaline flux will ensue, either hydroxide ions will enter the cell or hydronium ions will leave, these ion fluxes will occur spontaneously because pH gradients are not stable, and will collapse to the lowest energy level, meaning that a pH gradient across a semipermeable membrane will eventually collapse to yield the same pH on the inside and the outside of a membrane separating two compartments. In the example above, the pH will eventually become 9.0 on both sides of the compartment, and the biocide of the invention is designed to increase the rate of pH gradient collapse. A cell with a cytoplasmic pH of nine will die, because enzymes and proton gradients within the cell are function at a neutral pH of about 7.0 for most living organisms. Prolonged or severe alkalinization kills all known living cells. Even alkaline extremophiles deal with an alkaline external pH by using hydroxide pumping mechanisms, and even they cannot tolerate an alkaline internal pH, with the biocide killing even alkaline extremophiles by overwhelming the pumping mechanisms. In the germicide of the invention, the ammonia or other long chain detergent compound functions as a hydroxophore, and free base ammonia enters a cell in the neutral form and accepts a proton. The loss of a proton inside the cell is an event that corresponds exactly to the entry of a hydroxide anion because at a given pH, hydroxide anions and protons are linked by an equilibrium constant, it is impossible to change the concentration of hydroxide without altering the concentration of protons. In summary, the ammonia or other long chain detergent component results in accelerating the rate of alkalinization. A variety of other base materials to increase alkalinization may also be suitable.
[0021]Further examples of detergents that have been shown to be effective for use in the composition and method of the invention are set forth in Table 1 below, but it is understood that this list is not limited, and other detergents or agents providing the function of the detergent component may also be suitable.
TABLE-US-00001 TABLE 1 Number of Name Abbreviation Carbons Full Name CTAC 16 Cetyl trimetylammonium chloride CTAB 16 Cetyl trimethylammonium bromide TTAC 14 Tetradecyl trimethyl ammonium chloride TTAB 14 Tetradecyl trimethyl ammonium bromide SDS 12 Sodium dodecyl sulfate STS 14 Sodium tetradecyl sulfate SCS 16 Sodium cetyl sulfate SOS 8 Sodium octyl sulfate HAD 16 Hexadecylamine TDA 14 Tetradecylamine CHAPS XX 3-[(3- Cholamidopropyl)dimethylammonio]- 1-propanesulfonate DAPS XX 3-(decyldimethyl-ammonio) propane sulfonate
[0022]A second component, being a second hydroxophore is present in the biocide composition, such as hexadecylamine (HDA) or aniline as particular examples. The concentration of this component may be in the range of 5-40 weight percent for example, relative to the other components. Other concentrations may be suitable depending on the application, and as with the first component, again is generally in the mM range in a concentrate formulation that is dilutable for use. The HDA molecule for example has a long hydrophobic tail and an amine head group. The hydrophobic tail initially inserts into the plasma membrane of living cells and the amino head group remains in the water exposed to the external compartment. Compounds like HDA are known to flip-flop in the membrane so that the free amino group can travel from the external compartment to the internal compartment, but the molecule remains anchored in the plasma membrane. When flip-flop does occur, a hydroxophore action is evident, since a free ammonia group has just been transported from the external to the internal compartment. Note that this action is synergistic with the first component, such as free ammonia. A second damaging event conferred by HDA has to do with disruption of the plasma membrane caused by the insertion of the hydrophobic tail, HDA is essentially a detergent and will cause increased fluidity and disruption of the membrane, with such disruption leading to increased permeability of ammonia and an increase in flip-flop. Lastly once the HDA head group appears in the internal compartment it becomes protonated turning into ammonium. Effectively, this creates increased positive charge on the inner face of the membrane. Most plasma membranes in living cells maintain an external positive charge, HDA or other suitable materials therefore changes the membrane potential creating a positive charge on the inner leaflet of the phospholipids in the plasma membrane. All three actions of HDA are deleterious to living cells and synergistic with the first component such as ammonia. Alternatively, this component may be substitution of aniline for HAD, which also created a very lethal biocide and confirms a mechanism of action.
[0023]A third component in the biocide composition is an alcohol, such as ethanol. The concentration of this component may be in the range of 1-10 weight percent for example, relative to the other components. Other concentrations may be suitable depending on the application. Ethanol freely dissolves in the hydrophobic core of the plasma membrane and fluidizes that membrane. The fluidization caused by ethanol is synergistic with the fluidization effects of HDA. Ethanol also changes the polarity of water making the solvent much less polar, this circumstance causes more free base ammonia to appear since that decrease in polarity makes the ammonium ion much less stable and favors an increase in the percentage of amine free bases. Ethanol is therefore synergistic in causing the hydroxophore action to increase, and helps cause a rapid increase in alkalinization. Other alcohols in relatively low concentrations may also be used. For example, alcohols such as including but not limited to methanol, propanol, butanol, benzyl alcohol have been found to be effective in the composition and method of the invention.
[0024]The biocide composition of the invention greatly increases the toxicity by increasing the rate of alkalinization and can kill very quickly compared to other alkaline biocides. The biocide of the invention will also "auto-switch" off when the ethanol and ammonia evaporate, or it can manually be "switched off" by neutralizing it with non-toxic acetic or citric acid. Due to the synergistic effects of the components, the biocide results in rapid killing of the organisms, which is very desirable. For example, data indicate that the biocide achieves complete sterilization in a few minutes using a test bed organism, Vibrio fischeri. For a variety of applications, such as bio-terror attacks with pathogens, the "switchable" biocide/germicide of the invention would provide lethality to all known pathogens, while allowing the killing mechanism to be switched off after sterilization. The biocide uses alkalinity as the primary germicidal agent, and the lethality of the biocide can thus be instantly switched off by neutralization. At the same time, the individual components are individually benign, so that the separate liquid components can be stored for extended periods before use is desired, and pose no threat prior to mixing in just prior to use or in the field. The components will not significantly degrade upon long-term storage. Thus, the three components of the biocide composition when combined with alkalinity, these agents produce very effective biocides, but before mixing, the three components alone are relatively benign and pose little threat to humans, such as on skin contact. Also, due to the small concentrations, even upon contact with mucous membranes of the eyes, mouth or nose, though there may be slight tissue injury because those cells are permeable to the agents, the effects are minimized.
[0025]The proposed mechanism of action of the biocide includes a membrane fluidizing agent, which also helps generate a permeable hydroxophore in solution. A second agent disrupts cell membranes and inverts a membrane potential, while the third agent is a hydroxophore, and it accelerates the net transfer of hydroxide ions across the organism plasma membrane. The three components, when combined with an external alkaline pH gradient, generate a large alkaline flux which leads to cell death by rapidly raising the pH of the cellular cytoplasm. Notably, this killing mechanism can be easily "switched" off by neutralization to leave little to no residual toxicity after the biocide has served its purpose.
Example 1
[0026]V. fischeri was grown overnight until the culture reached log phase and were brightly luminescent. Since bacterial luminescence is an ATP driven event, light emission is directly related to the metabolism and energy charge state of the organism. Lower luminescence levels correlate to lowered metabolism levels when compared to a non-treated control. It was previously established that when treated with known biocides, luminescence is abolished and does not recover. Samples at given concentrations were added to V. fischeri in a 24 well plate. A small amount was placed in a 96 well plate, agitated, and the luminescence was read in a TECAN well plate reader. For all figures, the total time period that V. fischeri was exposed to each biocide or component was between five and fifteen minutes. Results of testing show that Vibrio fischeri react to some of the individual components of the alkaline biocide in different ways. As shown in FIG. 1, the effect of ethanol at concentrations from 0%-10% on V. fischeri Luminescence are shown. The left side bars represent final pH of 7. The right side bars represent a final pH of 9. Low readings indicate killing. As seen in FIG. 1, V. fischeri is susceptible to ethanol; with even 1% concentrations show damage at pH 7 (and also at pH 9). V. fischeri treated with samples at a final pH of 9 showed higher luminescence than those treated with samples at a neutral pH. In other words, at a given concentration of ethanol, pH 7 seems to be slightly more damaging than the same concentration at pH 9. For example V. fischeri treated with 3% ethanol at pH 9 had a 40% higher luminescence reading than the same concentration at pH 7. This could be a result of stimulating the luminescence pathway through "irritation". Mildly alkaline environments may not be harsh enough to damage the cell but may be irritating enough to enhance the luminescence pathway. It is important to note that while a luminescence of 0% of control is designated as "killed", a luminescence higher than 100% of control is more difficult to interpret and may be due to the fact that the bacteria can generate a higher luminescence when stressed. From these test results, ethanol is the most lethal component of the alkaline biocide of the invention for V. fischeri. The purpose of this component is to fluidize the cell membrane to collapse the pH gradient. For other organisms, this component may be less effective than other of the components, wherein the combination of components synergistically provides for effective killing over a broad spectrum.
[0027]Turning to FIG. 2, the effect of the component HDA or a cetyl amine ranging from 0 mM-2 mM on V. fischeri luminescence was tested. The left side bars represent final pH of 7.5, while the right side bars represent a final pH of 9. FIG. 2 shows that HDA has little to no effect on V. fischeri at pH 7.5, however it does have a slight effect at higher concentrations at pH 9. A 29% decrease in luminescence is seen at 2 mM C2 at pH 9. At pH 7.5 2 mM C2 only shows an 11% decrease in luminescence. This does not follow the earlier trend of higher luminescence at higher pH. In the biocide, the ethanol and ammonia components are volatile. The HDA component has a very low solubility in water, but this is not a drawback because it is effective at low concentration (in combination with the ethanol and ammonia type components) and this minimizes any residual residue that would be left behind after using the biocide. The presence of ethanol or the like further increases the solubility level of the HAD or the like. For some applications, higher concentration of HDA or the like may be suitable, and once the three components are mixed, the solubility level of HDA will rise.
[0028]Turning to FIG. 3, the effect of ammonia ranging from 0 mM-50 mM on V. fischeri Luminescence is shown. The left side bars represent final pH of 7, while the right side bars represent a final pH of 9. FIG. 3 illustrates that the component ammonia by itself shows no difference from the control (pH adjusted H2O) at either pH 7 or 9, meaning V. fischeri is not affected by ammonia at 50 mM concentration or lower at these pHs. This is an important finding because the flux of OH-- into the cell is the major source of sequestration of H+ ions, which causes the interior cell cytoplasm to alkalinize and eventually leads to cell death. The flux of OH-- into the cell is the major killing event induced by this component. Samples with very high ammonia concentrations are not killing the cell any faster than samples with little or no ammonia. This means that without the other components, in the case of V. fischeri, ammonia at these concentrations alone does not produce enough of an alkaline flux to damage the cell. The components work synergistically in order for the biocide to work properly. Samples with very high C3 concentrations are not killing the cell or sequestering H+ any faster than samples with little or no C3. This means that without the other components, in the case of V. fischeri, C3 alone does not produce enough of a hydrogen ion flux to damage the cell. The other components are necessary in order for the biocide to work properly.
[0029]Turning to FIG. 4, the effect of pH from 7-10 on V. fischeri Luminescence is shown. An external pH gradient drives an influx of OH.sup.- into the intracellular environment and concomitantly creates a H.sup.+ gradient driving an H.sup.+ efflux, either pathway collapses the pH gradient and will alkalinize the cytoplasm, killing the bacterium. FIG. 4 shows that alkaline pH alone does not kill V. fischeri. All samples tested showed an unchanged or higher luminescence than the H2O control and the untreated control. As noted previously, a higher luminescence is seen with increased alkalinity (see FIG. 1). An extracellular alkaline environment seems to increase the luminescence. Whether an increase in cellular metabolism is producing a higher number of luminescent molecules per cell, or there is simply a "mild "irritant" effect, or the V. fischeri thrive at a higher pH is not yet determined.
[0030]Turning to FIG. 5, the effect of various killing agents on V. fischeri Luminescence are shown. Samples are shown at their final concentrations. The biocide listed on the far left is the biocide according to the invention, with a combination of the three components as described above, at pH 9. As seen in FIG. 5, the alkaline biocide according to the invention (listed as biocide in FIG. 5) is completely lethal to V. fischeri along with the other very harsh sterilizing agents shown in the figure. The advantages of the multi-component biocide according to the invention, such as compared with these other harsh sterilizing agents are as follows. Extreme lethality is generated, with no pathogens remaining to cause infection. The biocide of the invention utilizes an inward flux of chemicals that immediately interferes with cell metabolism and viability. The multiple components and multiple mechanisms provided by the biocide of the invention achieve complete lethality, with the chemical flux generated being invariably lethal to V. fischeri. Accordingly, extrapolation indicates that the biocide would be similarly lethal to any other microbes or pathogens. The biocide thus has a broad spectrum of killing activity is desired, with an overall mechanism that will destroy any known (or newly created) pathogen. The biocide achieves rapid killing, which is very desirable. The data indicate that complete sterilization is achieved at least in about 5-15 minutes using the test bed organism, Vibrio fischeri. The biocide has a short persistence time, with no long term toxicity remaining. As described, each component in the multi-component water based system is relatively harmless but, when combined and diluted, produces a potent biocide. The biocide is switchable between being a highly effective killing agent, while allowing instant chemical neutralization as a switch to immediately deactivate the biocide/germicide. Further, as several of the components have high vapor pressures, evaporation of these components after deployment of the biocide provides an "auto-switch", so that after sterilization, no long term toxicity can occur. The germicide also is inexpensive, portable, storable, safe and easy to use. The final concentration of the components is small and therefore, the composition is less harsh on the surfaces or materials it is used.
[0031]Turning to FIGS. 6 and 7, there is illustrated the principle that a wide variety of detergents or alcohols work as a component of the biocidal composition. In the first experiments shown in FIG. 6, the concentration of ammonia was held constant at 1 mM, while the ethanol concentration was held at 0.5% and the pH was adjusted to 9. In this example, the final concentrations in the biocide are 1 mM NH3, 0.5% EtOH, and 0.05 mM of detergent, and pH was adjusted to 9.0 with 1.0M sodium hydroxide. The type of detergent was then varied at a concentration of 0.05 mM. The detergents used in these examples were CTAC, CTAB, TTAC, TTAB and SDS. All of the detergents showed some degree of killing, with it being understood that the detergent concentration of 0.05 mM was very low. The use of very low detergent concentration was purposefully done in these examples in order to show variations in the killing power of the different detergents. If the detergent concentration was raised to 1 mM (which is still very dilute), all the detergents were found to kill effectively. Similarly, analogous experiments were conducted to show the killing power of various alcohols within a constant formulation. In the experiments shown in FIG. 7, the composition included an ammonia concentration that was held constant at 1 mM, a CTAB concentration of 0.05 mM and the pH was adjusted to 9. In this example, the final concentration in the biocide are 1 mM NH3, 0.05 mM CTAB, and 0.5% of alcohol, and pH was adjusted to 9.0 with 1.0M sodium hydroxide. The type of alcohols were then varied at a concentration of 0.5%. The alcohols used were methanol, ethanol, propanol, butanol and benzyl alcohol. All of the alcohols showed some degree of killing, with it being understood that the alcohol concentration of 0.5% was very low. The low concentration of alcohol was purposefully done in order to show variations in the killing power of the alcohols. If the alcohol concentration was raised to 1% (which is still very dilute), all the alcohols were found to kill effectively.
[0032]In the composition, the particular components are only examples, and other similar components are contemplated. The components work together to greatly increase killing efficacy. The components each have mechanisms, that work synergistically together to increase the biocidal activity. For example, ethanol or the like suppresses ionization, such that the ammonia tends to exist in neutral form that allows the ammonia (or the like) to enter the cell very rapidly when neutral ammonia (or the like) builds up around the pathogen. The component of ethanol, or the like, suppresses ammonium ion creation and creates more free ammonia (or the like). Further, the ethanol or the like fluidizes the cell membrane to increase the flux of ammonia into the microbes or pathogens. The HDA or the like component also assists by reversing the membrane potential, and fluidizes the membrane and carry a free ammonia into the cell and take a positive charge from the outside of the membrane to the inside. Flipping the electrical potential of the membrane also causes problems in cell function to facilitate killing efficacy.
[0033]Further, the biocide composition chemicals involved are very inexpensive, and the components are stable and do not decompose during long term storage. A high initial concentration of each component enables portability when water is available. Mixing the components immediately creates the potent germicide. Spraying and soaking are acceptable modes of application. Thus, the composition may be stored as the individual components in a suitable container or storage system, until use of the biocide/germicide is desired, and then mixed and deployed as needed. As merely examples, the components may be stored in a container and separated by a frangible material until use is desired, wherein the frangible material can then be ruptured to cause mixing of the components for use. Alternatively, the components could be stored separately and combined and mixed at a spray nozzle for example. Any other suitable arrangement for selectively storing the components and subsequently mixing them for use are contemplated. Further, the components may be mixed and stored in a container for use if desired, such as via a spray bottle or the like.
[0034]For example, an application of the biocide/germicide may relate to cleaning and disinfecting of household surfaces, such as kitchen counters, bathroom surfaces, walls, floors, etc., similar to many household types of cleaning/disinfecting agents currently in the market. Other areas, such as in hospitals, ambulances, airplanes or a variety of other environments and applications are also suitably decontaminated using the composition of the invention. Cleaning of industrial food processing equipment or other industrial machines may also be possible. The advantages of the present invention allow for highly effective disinfection of such hard or other surfaces, while not leaving any lasting toxicity or unwanted residue, and not leaving any harsh chemicals that could affect people adversely. The composition may be used in a manner similar to other such cleaning/disinfecting products by mixing with water and applying to surfaces via wiping or the like, or by spraying or other suitable means.
[0035]The composition could also be used in the disinfection/decontamination of water or other fluids, such as in a water treatment facility. For example, water to be treated may be contained in a tank or the like, and a suitable amount of the composition of the invention may be introduced into the water. Mixing of the composition with the body of water may allow dispersion of the biocide to treat the totality of the water. Mixing or bubbling of the water after some dwell time may also allow the volatile components to evaporate more quickly to switch off the disinfection activity and leave the water decontaminated. Such a process could also be used in other applications such as fish, shrimp or the like farms, where fish or shrimp are grown in a pond or the like. In such situations, it is possible for the pond to become contaminated with bacteria or viruses for example, that can decimate the animal population. Further, in many such environments, it is possible that water from other sources, such as a nearby body of water or bay, comingles into the pond, either potentially bringing in pathogens to the pond water, or allowing escape of contaminated pond water into such other bodies of water. Such problems not only cause significant damage to the farming activity, but any such releases can also impact wildlife or vegetation in the other bodies of water. The disinfecting composition of the invention may be used to sterilize water coming into and out of such ponds or the like. Other disinfectants, such as chlorine cannot be used because they introduce halogenated compounds into the environment. In an example, water supplied to or from such a pond could be first sent to a holding pond to clean/decontaminate the water coming in or to be released, with the biocide composition introduced into the holding pond for treatment of the water. Upon being decontaminated, the composition may then be switched off and the decontaminated water introduced into or released from the pond. As an example, the switching off of the biocidal activity of the composition may be performed by air bubbling in the holding tank which accelerates removal of the volatile components by evaporation. Testing of the pH level of the water in the holding tank will indicate when it is switched off, such as at around a pH of 7. Other water treatment applications are contemplated, such as treatment of ballast water from vessels for example.
[0036]As another example, the biocidal composition may be used to remediate bio-terror attacks with pathogens, or spills or other releases of pathogens, the biocide of the invention may be deployed over large areas for sterilizing the pathogens quickly, and then the lethality of the biocide could be instantly switched off by neutralization. The components may be stored in large containers and individually pumped to a spray nozzle where they can be mixed with water for deployment. Alternatively, the components could be mixed in the field and deployed by spraying or soaking.
[0037]Based upon the foregoing disclosure, it should now be apparent that the methods of producing biocidal/germicidal compositions, methods and devices provide a highly effective system for decontamination of surfaces, water or other fluids, and many other applications that are too numerous to describe. The components used in the composition can be modified while still performing the synergistic functions with one another. Example apparatus for the deployment of the decontamination composition are likewise too numerous to describe, as a wide variety of devices are envisioned. It is, therefore, to be understood that any variations evident fall within the scope of the claimed invention and thus, the selection of specific component elements can be determined without departing from the spirit of the invention herein disclosed and described.
Patent applications by FLORIDA GULF COAST UNIVERSITY
Patent applications in class Ammonia or ammonium compound containing
Patent applications in all subclasses Ammonia or ammonium compound containing
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Teacher At Sea Logs
RITAS Expedition
CTD Data Check it Out!
This is one data set from a CTD. The graph has a huge amount of information. On the left hand side the data table is showing a variety of "live" data, meaning it changes constantly as the CTD is deployed and recovered. The y axis of the graph is the depth of the CTD in the water with 0 meters (the surface) at the top. The four different colors show the following: green is a measure of chlorophyl, grey is a measure of how clear the water is, blue is the amount of salt in the water, and red is the temperature.
Take a look at the graph. What are trends or patterns you notice? What does this graph tell you about different layers in the water? There is SO much information that can be pulled from just one CTD data set. We have done over 70 of these! So much DATA!
Another question: What is chlorophyl? Why is there more chlorophyl near the surface than down deep?
Track a Drifter
A few weeks ago we deployed drifters (see picture). Debbie labeled one with the name of her school and Todd labeled one for his school. The drifters collect and transmit data for up to 3 years! You can now go to a website and track the location of the drifters.
Website: http://www.aoml.noaa.gov/phod/dac/gdp_track.php
Code for Debbie's tracker: 44925
Code for Todd's tracker: 44932
Red Sky
Last night we experienced a fabulous sunset. It lasted for over an hour. The color changes were amazing. I know that pictures will not do it justice, but I will include one. There is a famous sailor's quote that says "red sky in morning, sailors take warning; red sky at night, sailors delight." Can anyone give me more information about this saying?
New Question for Students
We had a rough night at sea last night. Lots of rocking and rolling. Almost fell out of bed more than once. I hope as we go south we will move into some nicer weather again.
Here is a new question: What is the science behind someone getting sea sick? In other words, what is happening in the body (the biology) of a person who gets sea sick?
May 17
The seas are back! The motion today is a little different; there are some very high swells. If you are working in the main lab this means everything that is not tied down goes rolling across the table. This sometimes includes people. Our chairs are all tied down, so if you hold onto the table you can prevent yourself from sliding into the wall. Before the trip began we all tied down our computers with clamps, hooks and bungee cords.
Outside the weather is just slightly overcast. The temperature is around 45 degrees Farenheit, which is pretty warm. On our first cast of the UCTD the birds were very lazy. Only a couple tried to touch the cord, but there was a rather large audience sitting on the water observing. Someone asks me about seeing the birds at night. We see the birds day and night, rain and shine. The crew members told me that they often have hitchhiking land birds but most don't make it all the way back to land.
Eddie the Egret
At approximately 1:00 AM on my watch we were doing the UCTD from the fantail of the ship. The sea birds were playing their usual game of seeing how close they get to the cable without actually touching it. There are usually about 10 birds that compete in this game. Suddenly I noticed a bird that did not belong. It was an egret and it wasn't out playing with the other birds. It was perched on the guide wire on board ship. I know that most of you know what an egret looks like; they are very common in Florida. As a matter of fact I see ten to twenty of these birds on a daily basis around my house. I knew right away this bird was out of his element, 400 to 500 miles from the closest land. It stayed with us all evening, overcoming his fear of man in favor of his own survival. Sadly, by morning he was nowhere to be found. It just seems funny to me that a common Florida bird winds up on a vessel with another common Florida species, me!
May 12
For time purposes we did only the outer points of the larger grid. We are now back on the smaller grid collecting a second data set. We are about to stop at HR08 for a CTD and then we will continue south.

subset: commoncrawl


text:
realmagick.com The shrine of knowledge.
- Volga beckons a novel cruise
- Volga takes away the additional sheen of the characters, since the narrative involves majestic personalities, who had towering presence in the history, like Kandukuri Veeresalingam, his wife and active abettor of his espoused cause Rajyalakshmi, Unnava ...
- Review: Sweet Dreams!
- And for every glass of wine poured on the countless evening out the lead (Anmol KC and Samragyee Rajya Laxmi Shah) takes, there is a borrowed one-liner taken straight from a Hallmark greeting card, that too spoken without any conviction.
- Soulless dreams
- The boy, who doesn't believe in love, falls in love with another spunky girl (Samragyee Rajya Laxmi Shah). From hate to love story, Dreams tells us how Avi and Kavya (Anmol and Shah respectively) fall for each other eventually deepening their love.
Rajyalakshmi is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Rajyalakshmi books and related discussion.
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New Three Bridges Park to open with family activities
Music from De La Buena, kayak rides and food trucks will be included in the opening of Three Bridges Park on July 20.
The new park, developed in the Menomonee Valley from a long-abandoned rail yard, will open at 10 a.m. with short group processions from each bridge to an area of the park across from the 33rd Court Bridge. There will be a ceremonial blessing by a Potawatomi Tribe elder at 10:15 followed by kayak demonstrations, fishing, live music, food trucks and kayak and bike rides until 2 p.m. »Read Full Article
TV stations pile up new ways to cover same old snow story
Snow news is good news for TV stations.
But as the winter of 2014 grinds on, they are forced to come up with new ways to illustrate the same old thing. »Read Full Article
Grand opening Wednesday for Brewtown Eatery on the south side
Brewtown Eatery, a restaurant and bar at 5121 W. Howard Ave. that serves pizza, pub food and a Friday fish special alongside craft beers and infused spirits, is marking its grand opening Wednesday.
It opened quietly in mid-January in part of the space that had been Paulo's Pizza. »Read Full Blog Post
Phantogram; Ralph Stanley ; We Are the In Crowd; Angel Olsen; Solids; Lost in the Trees; Live at the Boarding House
Phantogram »Read Full Article
Countdown to Spring: 31 days
Eccentric pop star Lady Gaga will be the second musical guest on "The Tonight Show with Jimmy Fallon." Gaga will headline the Marcus Amphitheater at Summerfest June 26. Associated Press photo by Trae Patton. »Read Full Blog Post


text:
LonghornThe codename given to a Microsoft operating system while in its development and beta phases. The Longhorn codename is the operating system that was released under the official name of Windows Vista. Vista was released worldwide on January 30, 2007.
See also "Microsoft Windows Vista - An introduction to its features, retail versions and security" in the Quick Reference section of Webopedia.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
Webopedia's student apps roundup will help you to better organize your class schedule and stay on top of assignments and homework. Read More »List of Free Shorten URL Services
A URL shortener is a way to make a long Web address shorter. Try this list of free services. Read More »Top 10 Tech Terms of 2015
The most popular Webopedia definitions of 2015. Read More »
Java is a high-level programming language. This guide describes the basics of Java, providing an overview of syntax, variables, data types and... Read More »Java Basics, Part 2
This second Study Guide describes the basics of Java, providing an overview of operators, modifiers and control Structures. Read More »The 7 Layers of the OSI Model
The Open System Interconnection (OSI) model defines a networking framework to implement protocols in seven layers. Use this handy guide to compare... Read More »


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Spotify finding home with Android 2.1?
If you are in Europe and have an Android device then you will know just how nice it is to have an app like Spotify at your disposal. For the Android users in the U.S. though we could only hope for some love. Rumors flying around (via TechCrunch) are suggesting that the Spotify app might find it's way here.
The aggressive negotiations with labels over price for a U.S. launch have been met with some little movement from both sides-up until now. The labels wanted a paid app to almost total $14 a month subscription and Spotify wanted to run it for free with adds supporting the widely loved music app. From what TechCrunch is reporting a compromise has been reached, but only a "very limited" amount of people will actually see a free app – the time being.
What is also promising is that they have confirmed that Google and Spotify have had convo's that the long awaited app with be built in to Android 2.1 and will be on the Nexus One at launch. Google wanted Spotify badly enough that they were willing to cover the label costs for every user of $3 – $4 per month.
For more information on this subject stay tuned to DroidDog.com.
Via: TechCrunch


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realmagick.com The shrine of knowledge.
Progressivism Australia
A selection of articles related to progressivism australia.
Original articles from our library related to the Progressivism Australia. See Table of Contents for further available material (downloadable resources) on Progressivism Australia.
- Morrison, Dorothy
- Dorothy is a Wiccan High Priestess of the Georgian tradition and an avid practitioner of the ancient arts for over 20 years. She teaches the Craft to students throughout the US and in Australia. Her interests include archery and bowhunting, magical herbalism,...
Real Interviews >> Authors
- Pagan Mythology
- Is the traditional story presented as an historical event that serves to illustrate part of the world view of a people or explain a practice, belief, or natural phenomenon. The mythological beliefs a culture shares gives shape to its actions and choices....
Paganism & Wicca >> Holidays
- What is a Druid?
- According to the New Age Dictionary a Druid is defined as "a member of Celtic priests, poets, healers, and judges in pre-Christian Britain, Ireland, and France." Too the best of our knowledge that is what the Druids were, which implies that they...
Religions >> Druidism
- What is the History of Reiki?
- Usui Shiki Ryoho: The Usui System of Natural Healing Ancient Origins The Development of Usui Reiki Dr. Mikao Usui Dr. Chujiro Hayashi Hawayo Takata Mrs. Takata Talks about Reiki (transcript) Usui Shiki Ryoho: The Usui System of Natural Healing Reiki In Japan...
Body Mysteries >> Reiki
- Pagan Holidays for the Southern Hemisphere
- Many of the readers of RealMagick hail from the Southern Hemisphere. For them, the standard progression of the seasons is shifted... I.e. they are celebrating spring in Brazil, when those of us in the Northern Hemisphere are celebrating Fall. Clearly the "...
Paganism & Wicca >> Holidays
- Atlantis
- There are fragments of the 'Atlantis' legend in almost every culture around the world. This suggests, but does not prove, that the legend is based on a very ancient truth that was known by the forebears of each of these cultures. Our main source of...
Saga of Times Past >> Legend and Prehistory
Progressivism Australia is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Progressivism Australia books and related discussion.
Suggested News Resources
- Must Pack Heat: The Case for Mandating Gun Ownership
- A population that is comfortable around guns is a population that is comfortable using them—and sometimes using them on innocent people.
- Inside The Australian Sex Party: Politics, Progressives And Porn
- It's the party with the most provocative name in politics, but the leader of the Australian Sex Party says it is underpinned by a few key policies -- none of which include sex.
- Group in Australia slams arrest of journalists
- PETALING JAYA: The detention of two Australian journalists was a deliberate move by the government to frighten the press, claims a group in Australia.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Progressivism Australia Topics
Related searchespropaganda etymology
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text: Members-only sample sale sites like Gilt Groupe are growing in number. But even as getting designer duds at deep discounts becomes easier, deals on makeup are almost non-existent. Or were almost non-existent, anyway. Enter The Fairest, an online makeup sale site, launched yesterday with offerings from Stila (at 50 percent off) to Jurlique (almost 70… READ MORE »


text:
realmagick.com The shrine of knowledge.
- TV Recap: Battlestar Galactica - Faith
- She's babbling a lot of stuff that sounds like a combination of weird mataphors and commands to control the ship. Twice, she says "The children of the one reborn shall find their own country. End of line.
Mataphors is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Mataphors books and related discussion.
Suggested News Resources
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Mataphors Topics
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text:
Clarins Enchanted Summer Color Quartet & Liner Palette ($40.00 for 0.17 oz.) contains four eyeshadows and one eyeliner shade. Each eyeshadow has a subtle design on top, which does disappear with the first use. There are two dual-ended sponge-tipped applicators. The entire palette is encased in a "gold" plastic compact–it looks more luxe than it feels as a result. There is a full-sized mirror on the interior.Read Full Review
Clarins Enchanted Summer Collection for Summer 2012
Clarins Enchanted Summer Collection for Summer 2012
Instant Smooth Crystal Lip Balm ($24.50) (Limited Edition)
Clarins Instant Smooth Crystal Lip Balm offers the magical combination of crystalline transparent color and the comfort and repairing action of a balm. It glides on beautifully in four limited edition shades.
- Crystal Coral Sheer coral
- Crystal Pink Sheer pink
- Crystal Red Sheer red
- Crystal Violet Sheer violet
Enchanted Summer Eye Quartet & Eyeliner Palette ($40.00) (Nordstrom Exclusive) (Limited Edition)
The Clarins Enchanted Summer Palette features four luminous eye shadows in a powder motif inspired by exotic travels, plus a pearlized-brown eyeliner for a truly intense look.
Bronzing Powder Duo SPF 15 ($34.00)
- Light For light skin tones
- Medium For medium skin tones
- Dark For dark skin tones
Colour Quench Lip Balm ($18.00)
- Jaipur Pink
- Delhi Nude
Kohl Kajal ($24.00)
- Black Black
- Violet Purple
availability: May 2012, now at Nordstrom
See more photos!
Continue Reading
Clarins Spring 2012 Collection: Colour Breeze
Clarins Spring 2012 Collection: Colour Breeze
It's like the first signs of spring, a certain poetic grace and a hint of casualness. It's the sheer lightness of a high-shine lip gloss, exquisitely smooth powders, fresh and truly unique textures; tender yet vibrant shades. It's a bright, luminous complexion, beautifully enhanced cheek bones, ultra-shiny lips and naturally unsettling eyes.
Face Palette ($35.00) (Limited Edition)
- Colour Breeze Illuminates the complexion with a matte finish
Eye Quartet Mineral Palette ($40.00) (Limited Edition)
- Blue Sky Blues, white, teals
Instant Light Blush ($28.00) (Limited Edition)
- Vitamin Pink Pink
- Coral Tonic Coral
- Brown Fizz Bronze
Gloss Prodige ($20.00) (Permanent)
- Chocolate Brown
- Rose Soft pink
- Nude Nude
- Grenadine Red
- Candy Berry
- Raspberry Raspberry
- Blackberry Deep berry
- Papaya Coral
Joli Rouge ($24.00) (Limited Edition)
- Poppy Red Red
- Baby Pink Pink
Joli Rouge Perfect Shine Sheer Lipstick ($24.50) (Limited Edition)
- Pink Magnolia Pink
- Pink Coral Pink-coral
availability: February 2012 at all Clarins counters, clarins.com
See more photos!
Continue Reading
10 Worst Beauty Products of 2011
10 Worst Beauty Products of 2011
These are some of the biggest flops I tested out during 2011! Creasing, poor pigmentation, grittiness, dryness, you name it, you'll find it on this list!
- MAC Interior Life Eyeshadow Quad
- Dolce & Gabbana Sweet Temptations Eyeliners
- MAC Street Art Eyeshadow Palette
- Dior Blue Tie Palette
- YSL Volupte Sheer Candy Lipstick
- MAC Evil Eye Eyeshadow Quad
- NARS Celebrate Soft Touch Shadow Pencil
- MAC Miss Piggy Pink Eyeshadow
- Clarins Barocco Gold Shimmering Powder
- MAC Big Bounce Shadows
What was the worst product you tried out this year?
Clarins Sunset Rouge Prodige Lipstick
Clarins Sunset Rouge Prodige Lipstick ($24.00 for 0.10 oz.) is a brightened tangerine orange with peach and white micro-shimmer and a glossy shine. On my lips, it looks a bit coral-orange. The color coverage is semi-opaque; it delivers a healthy amount of color, but there's enough translucency that my natural lip color shows through, too. While the texture was smooth overall, it did not apply as evenly as I'd like. It reminded me of Guerlain Orange Euphorique, which is a little brighter and more opaque. Chanel Sari Dore is more opaque and darker. MAC Made to Order is similar but doesn't have as much gold shimmer.Read Full Review


text:
Skip to comments.Coast to Coast AM Tuesday 4/10/12: "Government Control".
Posted on 04/10/2012 9:22:45 PM PDT by Cringing Negativism Network
Looks like a FR sort of show tonight on C2C.
From the show preview:
"Author Sharon Sebastian argues that Socialist/Marxist influences on current government policies, and expansion of government controls threaten our quality of life and freedoms. "
(Excerpt) Read more at coasttocoastam.com ...
Don't prepare microwave popcorn, in the tinfoil please.
Just joshing, actually a big fan.
Back in 2008 I had the feeling that George Noory was pro-Obama. Maybe I misread him.
Did the Shadow People© find Bigfoot before they were abducted and experimented on on the backside of Planet "X"? With all that's going on, I can't keep up with these events.
Jiffy Pop. You get your popcorn & tin foil at the same time! ;-)
Could be he changed his mind. Many years ago I got trashed by Boortz for standing up for RKBA. He seems to be smarter now, on that issue anyway.
these people are always pro bamey....its the pubs, donchaknow....their evil....and those rinos, like romney, just the worse....worse than bamey.....*sigh*
Nut-job Conspiracy Theory Ping!
To get onto The Nut-job Conspiracy Theory Ping List you need to threaten to report me to the Admin if I dont add you to the list...
Art Bell is Reagan. Noory is Bush I.
Show starts in about 10 minutes.
For those not familiar with the show, it's covered this time every night on somewhere around 600 am radio stations - pretty much wherever you are reading this in the States if you go find your radio, turn it on and check the top 5 am stations you'll probably run into it.
I wonder if the Kook 2 Kook krowd is finally waking up and rubbing the starry eyed sleep out of their eyes.
The eyes have always been open. Considering they were the first large talker to have on birthers and have always talked about Gov't control and world government. Shrug, its just entertainment, right?
Just noting, the show has a (huge) audience.
A large part of which spans middle America.
Perhaps some well spoken FReepers might consider calling in (it's a talk show format).
Caution if you haven't listened to the show, yes it's out there, but downright addictive. Just have to discern for yourself what to keep and what to discard.
I don't think Noory is an 0bama fan now.
The topic was spiked.
It's not on the show tonight now?
Gone, it appears.
Just have to discern for yourself what to keep and what to discard.
Exactly! There is a lot of interesting and pertinent information on C 2 C.
Some FReepers are like Rush haters-—they have never even listened to the program.
I SO love Coast to Coast.
I wonder if the Kook 2 Kook krowd is finally waking up and rubbing the starry eyed sleep out of their eyes.
Yes. Night night to you.
Maybe we can convince Noory that Obama is being controlled by Aliens....
[ The topic was spiked.
Its not on the show tonight now?
Gone, it appears. ]
Aliens controlling us, well Obama's Marxist Ideals ARE ALIEN!!! especially to freedom loving Americans.
They are talking about Government Control and how it would break down if the Aliens arrived, LOL.
Maybe Aliens would save the Republic....
Screenshot from an hour ago:
Maybe Aliens would save the Republic....
I'll get my flashlight and signal them to come and save us.LOL
Seriously, there are some good guests on C 2 C. For instance the Conservative Economists are very good and Jerome Corsey can be insightful.
Discernment is the key. Sleep is always around the corner.
No harm is done.
He will not allow Dr. Corsi a regular on C2C for years to talk about questions of Obama's eligibility though a couple of years ago Noory did spend five or ten minutes on the birth certificate.
Noory did permit Alex Jones to criticize Obama on a recent show.. during the Bush years when Jones was trashing Bush he was a virtual co-host on C2C.
Is he afraid of the White House? No I think it's just a matter that Noory is what we used to call FDR Democrats. He hates Daddy Warbucks Republicans and certainly despises Bush, Cheney and Halliburton.
But the C2C clowns claim to be nonpartisan, they have millions of apolitical listeners, and this is an election year. C2C may as well be paid ads attacking Republicans and swooning over Obama.
I listen to George Noory occasionally. He definitely favors Obama and the libs. If he goes along with someone saying the government is out of control, he always manages to blame it on the conservatives and those nasty corporations. Art Bell was much more conservative.
LOL it's a real conspiracy.
(Maybe George will explain)
Or maybe...
Sometimes I think Coast to Coast takes on serious conservative issues just so that they can be lumped in with all the bizarre crazy stuff.
Screenshot from an hour ago:
See post 28, hope it stays.
Fixed it I thnk, see post 28
Government Control is not a conspiracy.
They swarmed Noory and C2C with complains about Ms Sebastian.
Noory has permitted maybe four shows to be critical of Obama in four years -- and he has Dr. Corsi on BUT does not allow him to criticize Obama. The left thinks that Noory is way too right wing.
BTW Noory and crew responded to the left's complaints but they did not and have never responded to any of my questions about show content.
Noory has responded on air to a couple of my non-political Fast Blast
C2C has had any number of guest quite transparently hostile to conservatives. In fact almost every guest is pro-Obama.
I am deeply disappointed in Noory for folding this way.
I've listened loyally since Bell was hosting. Very disappointed.
Yes Wells started out way to right of Noory but he did four shows in a roll where guests bashed Bush and he even commented on it. He followed them with an Alex Jones show suggesting that Obama may have had Breitbart killed. Since then it's been nonpolitical it seems to me. I guess Wells got the message.
Here's a DU comment, kind of representative:
"George Noory and John Wells are bending to politics, wacky, dishonorable, dehumanizing, weirdo tea party politics. I tried not to believe this but, seeing today's guest on the website just sparked me to click on the link in the description, which brought me to "Darwin's Racists"....That did it for me. I typed in the search "Sharon Sebastian right wing", was brought her to this site, and, clearly, no denying it any longer, Coast to Coast is inching farther and farther into right - wing foaming rabidism." [End of DU quote]
My experience with C2C dates to before it was C2C when it was a show that Bell did from KDWN studios in a hotel in Las Vegas.
But things changed..
Art Bell invested in "alternate energy" -- way more than he should have, he said a few times -- and every show he had after that included stuff about the dangers of "global warming."
Now in this election year C2C is a lackey of Obama and the extreme Left.
C2C should at least STOP lying that they are nonpartisan.
Dr. Corsi talking about Iran does not equate to right-wing extremism. The Left's complaints about him being on do not make sense. Noory will not let him talk about Obama's eligibility. It was clear also that Noory would not let Major Dames mention Obama's birth vis-a-vis eligibility. What the hell does the left have to complain about? They own the weekday host Noory.
This is a critical election year. C2C has influence. It has millions of apolitical listeners who vote.
Between the MSM and "nonpartisan" shows like C2C Obama could get a few million apolitical votes.
This is serious.. more than series it is that serious.
C2C is getting tiresome.
Art Bell invested in "alternate energy" -- way more than he should have, he said a few times -- and every show he had after that included stuff about the dangers of "global warming."
Now in this election year C2C is a lackey of Obama and the extreme Left.
I sent a request to the local station to replace C2C at least until after the election or have the Obama campaign pay for the four hours.
If you read the DU stuff (reply #34) you will see that they feeeeeeeeeeel that C2C is right wing crap and Noory is a "teabagger" or something.
.. based upon the politics of a regular guest or two like Dr. Jerome Corsi and Dr. John Lott. Obviously those Lefties do not listen to C2C.
The Left nevertheless complains about "birther" Dr. Jerome Corsi, a regular guest; but.. Dr. Corsi IS NOT ALLOWED TO TALK ABOUT Obams's eligibility. (Never in 12 years have there been any restrictions on bashing Bush or Cheney however.) And Noory lost his temper with Dr. Lott because Lott refused to address Obama as PRESIDENT! Obama.
Dr. Corsi talks about Iran, oil, and sometimes economics (hardly mentioning Obama, just "government"). The Left's complaints about him, et al. being on C2C do not make sense. Noory will not let anyone talk about Obama's eligibility. Noory would not let Dr. Corsi talk about his books on Obama. It was clear also that Noory would not let another long-time regular guest Major Dames mention Obama's birth. Dames believes that Obama was born in Kenya. Noory is totally on the Left's side vis-a-vis Obama.
I am old enough to know a FDR Democrat when I hear one. Noory is a patriot and good American, he just hates what he feeeeeeeeeels are Daddy Warbucks Republicans and all Democrats are good.. though Noory says that he likes Ron Paul.
If this year's election is close the apolitical voters that "nonpartisan" Noory influences could well be the winning margin for Obama.
Or just ask Scotty to beam us the hell up and outa here! :)
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All Articles Tagged "black history month"
16 Historic Images You Should Never Forget As Black History Month Ends
How did you celebrate black history this month? Now that one of the blackest Black History Month's in history is drawing to a close, lots of us are trying to savor that extra day. On Instagram, users all over the world have been sharing their favorite historical photos for Black History Month.
And we've takenthe opportunity to remember important moments and people in American History, and beautiful snapshots of life the way it used to be — and the way it's becoming. If you've yet to have a plate of soul food, listen to James Brown, or a long look in the mirror to appreciate your role in Black history, check out these amazing photos and celebrate with us.
What's your favorite photo from Black history in the past or present?
12 Moments That Made This Black History Month One For The Record Books
Don't let Stacey Dash fool you, Black History Month is vitally important. In a country that seeks to downgrade, disregard or outright ignore our accomplishments and our beauty, we need a month (and then some) to acknowledge the brilliance of Black people. And for one reason or another, it seemed like this year the celebration was unavoidable. Check out the moments that made this year's Black History Month one of the record books.
Working While Black: My White Colleagues Planned The Black History Month Program
As told to Veronica Wells
I loved my college experience. And I was adamant about doing something that I loved when I graduated. So when I saw that my university was hiring in the campus' diversity office, I quickly applied for the job. There are many subcategories and I didn't know exactly where I would be placed. When I was hired I learned I was going to be in the gender and sexuality division. Cool. I'm a woman. I, like many Black women, identify with being Black before being a woman, but I understand that there are specific issues women, of all races, still face in this world. So I went into it with an open mind.
The work was fine. In fact, I found that I really enjoyed it. There was always plenty to do and the longer I was there, the more ways I began to see and understand the ways in which women are still disenfranchised in our society. And it was good to know I was working to combat some of those attitudes.
But things took a turn for the worst when Black History Month came around.
You might assume that celebrating Black History at the diversity office might be a natural fit, a no brainer. But apparently there is still work to be done. I was still the only Black person in the gender and sexuality division. Go figure. So since I was the only one, I figured someone would want to tap into my expertise when it came to planning the annual Black History Month celebration. After the initial meeting, talking about the date and possible ideas, I didn't hear anything else about it. The date for the event got closer and closer and still nothing.
Finally, one day, a week before the program was supposed to be held, my supervisor sent me an e-mail asking me to come into her office so we could discuss the program. Being that it was only a week until the program, I knew this was about to be some bulls*t but I tried to have a positive attitude. She told me it was only going to take a minute.
When I walked into the office, she handed me the tentative menu for the Black History Month program. And asked me if any of the listed items were offensive.
I get it, the last thing you want to do is offend the Black community during Black History Month; but I could not believe that as the only Black person in that department, it never occurred to my coworkers to include me in any of the real planning of the event. I wasn't good enough to plan anything as simple as the playlist but, in an attempt to protect your neck, you want to ask me about the food.
I answered her questions, assured her that there was nothing wrong with the menu and then made my way back to my desk. But the more I was replaying the whole thing in my head, the more I realized I couldn't let this slide. I went back into her office and asked to speak with her for a minute.
"You know, I'm a bit offended that you only sought my opinion when it came to the actual planning of the Black History Month program. I mean, I am a Black woman, the only one in this office. My expertise on the subject goes beyond food."
She looked at me blankly while I finished speaking and then said, with little enthusiasm, "Well, you were brought in under the gender and sexuality services."
I closed my eyes and took a deep breath before continuing.
"There are no other Black people in this department. Why wouldn't you want someone with the actual knowledge of being Black to plan the program? Furthermore, you and I have had plenty of conversations about intersectionality. You know that being Black and being a woman are not mutually exclusive. There's more than one way to be a minority."
She kind of stumbled and fumbled over her words before saying that she would be sure to include me in the planning of the program next year.
At this point, if the diversity office doesn't understand intersectionality, I don't know if I'll even be around next year.
Unconventional Ways To Celebrate Black History Month (If You Haven't Already)
Black History Month doesn't have to be all Roots marathons and digging for discounted books on Black history. When Beyoncé celebrated Black History Month this year by releasing "Formation" (and giving a Super Bowl performance the world will never forget), she reminded us all that you can do more than the same ol', same 'ol to honor your blackness.
If you haven't taken time out to embrace the month yet, check out these fun ways to celebrate Black History Month in style, at home, with friends or family. Eat good food, watch good TV and think about how far we've come. It's not too late!
Let us know how you celebrated the month. Do you have a family tradition? An annual trip? Whether you spend a day watching films on Black history or plan a trip to another country, we want to hear your story so we can all get inspired for next year!
Tags:beyonce, black history, black history month, Formation
Betsey, Anarcha & Lucy: How The Foundation Of Modern Gynecology Is Based On Bodies Of Black Women
A colleague sent me an NPR story this afternoon that was tremendously fascinating while also being painful to hear. As she shared it with me, I wanted to share it with you in the hopes that we can all learn something new about our history, and the part Black women played in the advancement of medicine.
Their names were Betsey, Anarcha, and Lucy. They were the women whose bodies were used by physician J. Marion Sims for study and experiment. Trials and attempts that would eventually make him the "Father of modern gynecology." But as Vanessa Northington Gamble pointed out in the Hidden Brain broadcast, "We can't forget how that came to be."
Dr. Sims opened a clinic in Montgomery, Ala. and to stay afloat monetarily, he started doing work on plantations, providing medical care to slaves. But during that time, he came across captive women who had what we now know as vesicovaginal fistula. Gamble called it "an opening between the vagina and also the bladder or the vagina and the rectum, which usually comes after traumatic childbirth."
Sims decided to do tests on three particular slaves: Betsey, Anarcha, and Lucy. They were painful procedures, sutures done without anesthesia. And while Sims wrote in his findings that the women were eager to have the procedures done because the fistulas left them struggling to work and have babies, as slaves, they didn't have the option to give consent for such things either way. And when Sims did more and more of these procedures, conducting them in front of groups of medical professionals, the women had no say in being naked and experimented on in front of others.
To make matters worse, the surgeries were not successful early on, tearing, and causing even more pain. Sims did them from 1846 to 1849. Gamble stated that after 30 procedures on Anarcha, "he was able to perfect his technique."
And such advancements helped him succeed greatly in the medical field. He became president of the American Medical Association and a member of the New York Academy of Medicine. He became a renowned surgeon, and statues were eventually erected in his honor, including ones in South Carolina and Alabama. But knowing the truth behind such headways made in medicine, Gamble believes that the three women, whose voices and thoughts — aside from screams during procedures — were left out of Sims findings, deserve to have people know of their contributions. Muting them "mutes the story that the foundations of modern gynecology are based on the body and the pain of enslaved black women."
She continued, "He did treat white women. But he treated white women with anesthesia. Sims left – in the 1850s, he left Alabama and moved to New York City for health reasons. And he started a women's hospital in 1855 there. He gained a reputation as an excellent surgeon. And so that he did treat white women. But the technique had been perfected on the bodies of black women."
Please, when you have a chance, check out the thought-provoking NPR story below. How do you think Betsey, Anarcha, and Lucy should have their contributions recognized? And what should happen to Sims's statutes and legacy?
Say It Loud! Stars Celebrating Blackness
This month may have the honor of being the blackest Black History Month in the history of the holiday. When Carter G. Woodson first established the precursor for this holiday back in 1926 with Negro History Week, we doubt his wildest dreams could have anticipated what it would look like all these years later.
From Beyoncé to Kendrick Lamar, these celebrities have taken a stand for civil rights, Black history and showed everyone what it means to be Black, proud and powerful. And Black History Month isn't yet over, so we still have plenty to celebrate.
The following stars risked losing fans and upsetting the censors to bring us these moments during this very special time of year, and we're glad they did.
Did we miss any of your favorite moments from Black History Month 2016? Let us know how you've been celebrating our favorite time of year.
106-Year-Old Virginia McLaurin Dances Her Way Into The White House
President Obama is trending for his interaction with young children. But he's also pretty popular with the folks on the opposite end of the spectrum. Last week, to celebrate Black History Month, the White House opened its doors to Civil Rights leaders, the King family, young children and more.
106-year-old Virginia McLaurin was among the attendees. When they announced her name she squealed with excitement before bopping up and down. Then, when President Obama asked her if she wanted to meet Mrs. Obama, she moved with much vigor and much excitement.
Grasping both of their hands, McLaurin, a native of South Carolina who moved to D.C. in 1941, told the first couple "I thought I would never live to get in the White House. And I tell you, I am so happy to have a Black president…a Black wife."
That Black wife line tickled me to my core. Because not only is it obvious that Michelle is Black and has been Black, it's quite a nice image to see in the highest office of the land.
McLaurin, who will turn 107 next month, says she prays daily for her mind to remain sharp so that she won't become a burden to anyone. God has certainly been answering that prayer.
Check out the brief but inspiring video from her visit below.
What Happens When You See The First Couple And Say "Heeeeey Michelle!"?
I've said this so many times before. We look at Michelle Obama and see a friend, a homegirl. We know and respect the fact that she's the First Lady of these United States but she's also Auntie 'Chelle.
Clearly, based on a recent video from the White House, I'm not the only one who feels like this. One woman, in the presence of the President and First Lady, forgot where she was and hollered out "Heeeeeeey Michelle."
Realizing that she might have offended Mrs. Obama, the woman apologized.
Watch and see what happens next in the video below.
WATCH: POTUS: "We know it is black history month when we hear someone say 'heeey, Michelle! Girl. You Look so good!"https://t.co/3u36Y3iede
— ABC News Politics (@ABCPolitics) February 19, 2016
For those who can't watch now, Mrs. Obama told the woman it was fine. And President Obama smoothed things over, making a joke out of all of it. "We know it is Black History Month when you hear somebody say, 'Heyyyy, Michelle! Giiiirrrrrlllll you look so good!"
Man, we're going to miss them!
This little girl echoes our sentiments.
Sprout Celebrates Black History Month With Extraordinary Kids Making An Impact In Today's Society
Haile Thomas: Thank you, it was an honor.
How did you even hear about the opportunity?
They reached out to me and I'm very glad they came across me in their researching. It was really fun having the people come to my house and interview me and then getting to go to the studio to record the segment at Sprout. I was just excited to have another opportunity to talk about what I do and just spreading the message of healthy eating.
You're 15 now and so you learned that your dad had diabetes and you wanted to cook healthier for your family…
When I was about eight-years-old he was diagnosed with Type 2 diabetes and really ever since then it inspired my family to look at food and see what we were doing wrong and how to really start fixing our lifestyle.
What made you, at eight-years-old say, "ok, I'm going to take charge of this situation"? Have you always been interested in cooking?
Both of my parents are from Jamaica so cooking and food and really awesome flavor has always been a part of my life, but it was really when my dad was diagnosed that it started to be the main focus for our entire family. It really came from the fact that my mom was looking at the medication that he had to take and it sounded like it would make his condition worse than it already was. So then she said we need to start looking into how food affects our bodies and all together we started looking into all this information. Since cooking was already a large part of our family, anytime there was a meal I'd be right next to my mom, helping her and learning about healthy substitutions and swaps. That whole process was really a family effort.
What historical African American were you matched up with?
Lena Richards, she was a pioneer as someone of color being in the food history and she had the first cooking show as an African American, she's very inspiring.
So you cooked an original recipe for Michelle Obama, what was that like?
I made a black bean and corn quinoa salad for the First Lady for the Healthy Lunchtime Challenge which is an event the White House has been doing since 2012. I entered that contest and won for the state of Arizona and got a trip to the White House. I was part of this super fancy kids State Dinner and my dish was served among the other dishes that were entered.
Is that dish still a favorite in your house?
Yes, we love the quinoa salad and sometimes we switch it out with brown rice. It's just a really filling and tasty dish, it's super simple.
What are the ingredients you are enjoying cooking with these days?
I enjoy being really creative with the dishes I make so I do things like eggplant curry soup, I do pickled tomato soups and I also like playing around with zucchini noodles and carrot spirals. I also created a "tortizza" which is my tortilla pizza with sweet potatoes and mushrooms and bell peppers and barbeque sauce, and it was really good.
Do you want to be a chef and open a restaurant in the future or do you have totally different plans?
I feel like it would be fun to run a restaurant, a small place so cooking can still be enjoyable and not something that's super stressful. I'd serve smoothies and cool, creative salads and wraps would be sustainable for me because I travel so much for my organization. I definitely see food and cooking as a part of what I'm doing.
What are your doing now?
Currently, I'm studying at the Institute for Integrative Nutrition to be a health coach and I'll be the youngest one ever, so that will be really awesome. I'll be able to coach people and do consulting.
Wow, you're ready to go!
Thank you very much.
Tags:black history month
From Traffic Lights To Hot Combs: Things That Wouldn't Exist Without These Black Inventors
Unless this is your first Black History month, you probably already know that George Washington Carver was known as "The peanut man." But a great peanut butter and jelly sandwich isn't the only thing we have to thank African-American inventors for. Lots of the items we use and take for granted every day were brought to us by Black inventors.
From hair styling tools and products that we can't live without to medical procedures that keep our loved ones around, these inventions and innovations have been some of the most important. With that being said, let's take the time to be thankful to not only for the great George Washington Carver but a whole host of talented people for the following inventions that changed the world as we know it.
But speaking of delicious snacks, can you guess what other global food favorite was brought to us by an African-American inventor? After you scroll through, leave us a note in the comment section if you managed to guess right!


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The new home of
2 reviews
Heated indoor swimming poolShared gardens with furniture and play area
This stone-built Edwardian mansion with its converted coach house and stable is situated near Selkirk, in the heart of the Scottish Borders. Edinburgh to the north, and the Berwickshire and Northumbrian coast to the east, are all within a pleasant hour's drive.A perfect base for a peaceful country holiday, the cottages of Abbey Court, the individual character of the Coach House properties and the spacious apartments located within Whitmuir Hall itself, offer a range of accommodation for all tastes, seasons and party sizes. There are 32 acres of private grounds consisting of woodland and lawns, and a recreation building containing a heated indoor swimming pool (access by arrangement). Recreational possibilities include: 21 golf courses included in the Freedom of the Fairways Passport; walking, whether gently through woods and alongside rivers and towns, or on the more challenging Southern Upland and St Cuthbert's Ways; cycling for all abilities on quiet local roads, on the many great cycle routes nearby or try some downhill trails at Glentress Forest, Peebles (cycle store available at the properties); or have fun on their Go Ape tree top adventure course; fishing for salmon and trout on the River Tweed and its tributaries, or on stocked lochs for trout and coarse fish. Historic houses, abbeys and castles including Melrose Abbey (burial place of the the heart of Robert the Bruce); Mary Queen of Scots' house in Jedburgh; Traquair, the oldest continuously inhabited house in Scotland, and the Roman camp of Trimontium.Other activities in the area include horse riding, clay pigeon shooting and mountain biking, all within 30 minutes' drive. Good selection of pubs and restaurants locally.As well as holidays and weekend breaks, we also cater for family gatherings, anniversaries, weddings and any other celebrations with accommodation for larger parties. For group, corporate and party bookings, a bar and catering are available by arrangement direct with the owner. An initial grocery order service is available on request. Properties SW30, SW37, SW3701 and 15785 have electric showers.
In the main house. All on second floor: Living/dining room. Kitchen. 3 twin bedrooms. Bathroom with shower over bath and toilet. Separate toilet.
Cot and high chair on request. Fridge/freezer.
All properties: Electricity NSH and/or convector heaters and electricity by meter reading. Bed linen included. High chair. Digital TV. DVD. CD. Electric cooker. Microwave. Shared coin-operated laundry room. Shared payphone. Shared gardens with play area and furniture. Parking (2 cars). Cycle store. Shared indoor swimming pool, access by arrangement. No smoking.
21 reviews
Easy access to Border towns
With views over the Moorfoot hills, this spacious, detached holiday cottage has been crafted from original farm buildings. Edinburgh is just 16 miles away with particularly easy access using the park & ride. Explore Edinburgh Castle, Holyrood Palace, the cobbles of the Royal Mile and the thoroughfares of the New Town. Enjoy theatres, clubs, restaurants, art galleries and shops. Fishing and hill walking locally, with golf at Torwoodlee, 14 miles, and mountain bike trails for every level in Glentress Forest, 20 miles. Good access to the Border towns of Melrose and Kelso with their ancient abbeys, historic houses and gardens. Local shopping in Stow, 7 miles, with main shopping in Galashiels, 15 miles. Braehill House has a timber deck running along the front which can be accessed from each of the main living areas opening with a sliding wall from the dining area, and a sheltered, private, enclosed courtyard garden as well as a swimming pool and games room give endless entertainment, and the very spacious living areas with air conditioning provide both quiet and social spaces. Shop, pub and restaurant 7 miles.
Ground floor: Living room/dining area with 3 steps and wooden floor/kitchen. Second living room. Snug. Utility room. Games room. 1 double (5ft) bedroom with en-suite shower room. Bathroom with shower over bath and toilet. Open-tread stairs to galleried seating area. First floor: 2 double bedrooms. Second staircase to first floor: 3 bedrooms: 2 double, one with en-suite bathroom with Jacuzzi bath, double shower cubicle and toilet, one with sloping ceiling, 1 twin. Bathroom with shower over bath and toilet.
Woodburner in living room and second living room (initial fuel included). Oil central heating, electric underfloor central heating (in living/dining room/kitchen, November-March), gas, electricity, bed linen and towels included. Travel cot. High chair. Six satellite TVs. CD. Electric and gas hobs. Electric ovens. Microwave. Washing machine. Two dishwashers. Fridge/freezer. Wi-fi. Enclosed garden with patio, terrace and furniture. Large shared garden and children's play area. Barbecue. Ample parking. Cycle store. Indoor heated, private swimming pool (7m x 4m). Games room with pool table, table football and air hockey. No smoking. NB: Pond and 6 steps in shared garden.
19 reviews
This spacious home is ideal for family and friends wishing to share a wonderful holiday or special occasion. Relax in the hot tub or try an invigorating swim in the Rapid River spa, also enjoy the large enclosed garden with swings, a sunken patio, fountain and waterfall. Have fun using the barbecue and lunch alfresco, and make use of the wine fridge in the kitchen. Play the grand piano in the living room with its open fire or take a walk in the 90-acre community woodland. Visit the village park with facilities for all ages. Experience the excellent local activities, golf, salmon and trout fishing, horse racing, riding and ice skating. The Southern Upland Way and St Cuthbert's Way provide wonderful walking/riding, or explore the spectacular Berwickshire and Northumberland coast. Nearby, Kelso has cobbled streets and interesting local shops, restaurants and pubs. The ancient abbey, gracious town square and beautiful views along the River Tweed may be explored by following the town trail. Ideal for visiting the historic towns of Melrose, Jedburgh and Coldstream, while Edinburgh is only an hour by car. Home made meals, celebration dinners and housekeeping by arrangement. Shop ½ mile, pub 3 miles.
Ground floor: Living room with patio door. Second living room. Dining room. Dining room/kitchen. Second kitchen. 1 twin bedroom with additional pull-out single (2ft 6in) on request. Shower room with toilet. Separate toilet. First floor: 7 bedrooms: 5 double (one 5ft), 2 twin (both zip and link). Bathroom with roll-top bath, shower cubicle and toilet. Shower room with bidet and toilet.
Open fires in living rooms included. Oil central heating, oil, gas and electricity £70per week, £50 per short break (£100per week, £70 per short break October-April). Bed linen and towels included. Two cots. Two high chairs. DVD. CD. Three induction hobs (one in utility). Two electric ovens. Washing machine. Tumble dryer. Dishwasher. Freezer. Wi-fi. Grand piano. Large enclosed garden. Patio area. Decked area and furniture. Barbecue. Ample parking. Private hot tub. Rapid River swim/spa in glazed enclosure with loungers. No smoking. Please note: Unfenced pond with fountain in grounds, 9 yards.
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cottages.com is a trading name of Wyndham Vacation Rentals (UK) Ltd. Registered in England and Wales.
Registered Office: Spring Mill, Stoney Bank Road, Earby, Lancashire,BB94 0AA, UK
Company Registration Number 00965389. VAT Registration Number: GB 598 22 99 77
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cottages.com is the new home of cottages4you (Cottages for You).
cottages.com is a trading name of Wyndham Vacation Rentals (UK) Ltd. Registered in England and Wales.
Registered Office: Spring Mill, Stoney Bank Road, Earby, Lancashire,BB94 0AA, UK
Company Registration Number 00965389. VAT Registration Number: GB 598 22 99 77