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A Simplified Flow Cytometric Immunophenotyping Procedure for the Diagnosis of Effusions Caused by Epithelial Malignancies
Epithelial malignancies frequently metastasize to the serous cavities and result in symptomatic effusions. Cytology has high specificity but moderate sensitivity for the diagnosis of a malignant effusion. We developed and validated a simple, rapid, 3-color flow cytometric panel using the adhesion molecule Ber-EP4 to detect epithelial cells in effusions. One hundred ninety-five consecutive benign and malignant effusions received for routine cytologic examination were analyzed. Eighty-three fluid specimens were benign and 76 were malignant as judged by follow-up data. Ber-EP4–positive cells were detected with flow cytometry in 89.3% of malignant effusions. The sensitivity and specificity of flow cytometry was 88.15% and 97.64% compared with 73.68% and 100% on cytologic examination alone for the presence of a malignant effusion. Flow cytometry is a useful adjunct to cytology for the diagnosis of a malignant effusion and is particularly useful if the cytologic diagnosis is atypical/suspicious or if the cytologic preparations are hypocellular or hemorrhagic.
- Ber-EP4
- Effusions
- Malignant
- Immunophenotyping
- Flow cytometry
- Cytology
- EpCAM
Pleural, peritoneal, and pericardial cavities are commonly the site of metastasis of malignant tumors. In fact, in many patients, they are the first presentation of malignancy. Cytomorphology is the diagnostic gold standard for the diagnosis of a malignant effusion. Cytology, however, has a moderate false-negative rate attributable to screening, interpretation, and sampling errors.1 The specificity of cytomorphology is very good and ranges from 91% to 100%, with an average of 97.0%. Sensitivity ranges from 22% to 81%, with an average of 58.2%. Multiple specimens have been shown to increase sensitivity.1 Morphologic distinction between reactive mesothelial cells, macrophages, and malignant cells can be difficult, and hypocellular and bloody specimens are particularly challenging. Immunohistochemistry, often performed on paraffin-embedded cell block sections, is a common adjunct technique that serves to improve the sensitivity and specificity of cytology diagnosis. However, the use of immunohistochemistry is limited by the number of cells present in the cell block and the vagaries of immunostaining, which can result in delays in diagnosis. Hence, there is an unmet need for an adjunct technique that can increase the sensitivity and specificity.
Flow cytometric immunophenotyping is an integral part of diagnosing hematologic malignancies.2 It is possible to render a diagnosis on the same day of receipt of sample. Along with cytogenetics and molecular studies, it is an important ancillary test to H&E-stained examination as outlined in the World Health Organization classification of hematologic neoplasms.3 Recent advances in flow cytometry have made it possible to simultaneously measure 19 different parameters on a single cell at the rate of 10,000 cells per second.4 In spite of its obvious advantages, the use of flow cytometry for the diagnosis of nonhematologic malignancies is rare. It is widely thought that size and cohesiveness of malignant epithelial cells would limit its use in flow cytometry. However, many groups have successfully used flow cytometry in malignant effusions in which the epithelial cells are already suspended as single cells.5–9 A flow cytometric method has the advantage of simultaneously staining for other surface and intracellular markers.
Ber-EP4 (epithelial cell adhesion molecule) is a cell-cell adhesion molecule expressed on all epithelial cells but not on mesothelial cells or hematopoietic cells.10 Ber-EP4 is also expressed on all epithelial malignancies.11 Epithelial cells are not a normal component of serous cavity fluids; hence, their mere presence in an effusion can be used to indicate a malignancy. Immunophenotyping with the single epithelial marker Ber-EP4, in fact, has high sensitivity and specificity for the detection of malignant epithelial cells.12
We have developed and validated a simple, rapid, 3-color flow cytometric panel using Ber-EP4 to detect epithelial cells in effusions. This assay can be routinely used in conjunction with cytology for the diagnosis of malignant effusions.
Materials and Methods
Sample Preparation
One hundred ninety-five fresh benign and malignant effusions (pleural, pericardial, and peritoneal) received for routine cytologic examination were concurrently analyzed with flow cytometry. Aliquots of 50 mL of effusion fluid were centrifuged at 1,400 rpm for 10 minutes. The supernatant, large clumps, and any grossly visible mucoid material were discarded. The cell pellet was washed and resuspended in RPMI. The cell suspension was filtered with a 50-μm mesh filter to further remove any remaining dead cell clumps. An automated nucleated cell counter (Advia 2120, Siemens Healthcare Diagnostics, Tarrytown, NY) was used to count nucleated cells in the sample. An aliquot of 2 million cells in 100 μL of resuspended phosphate-buffered saline solution was used for immunophenotypic analysis.
Flow Cytometric Immunophenotyping
The samples were immunostained with CD45 peridinin chlorophyll protein complex, CD14 fluorescein isothiocyanate, and Ber-EP4 phycoerythrin or allophycocyanin (all from BD Biosciences, San Jose, CA) for 30 minutes at 4°C. BD FACS lyse buffer (BD Biosciences) was added for 15 minutes after staining to lyse RBCs. A total of 500,000 events were collected for analysis on a 2-laser, 6-color BD FACS Canto device using BD FACS Diva software (both from BD Biosciences). The data were exported as FCS 3.0 files and analyzed using Flowjo (Tree Star, Ashland, OR) analysis software.
Cytologic Preparation and Interpretation
A 50-mL aliquot of the fresh specimen was centrifuged at 1,800 rpm for 10 minutes. The resulting cell pellet was resuspended in 15 to 30 mL of CytoLyt (Hologic, Marlborough, MA) and centrifuged again at 1,800 rpm for 10 minutes. The pellet was divided for the preparation of 1 Papanicolaou-stained ThinPrep slide and 2 H&E-stained cell block sections. For the ThinPrep slide, 2 to 4 drops of the sediment were pipetted into a vial containing PreservCyt (Hologic) and incubated at room temperature for at least 20 minutes. A ThinPrep slide was prepared using the automated ThinPrep 2000 or ThinPrep 5000 instruments (Hologic). The residual cell pellet was prepared as a cell block by adding 1 drop each of plasma and a thrombin solution and stirring with a wooden applicator until a clot formed. The clot was wrapped in filter paper, placed in a cassette, fixed in formalin, and embedded in paraffin as a paraffin block for microtome sectioning per standard procedures. Immunohistochemical studies were performed on selected cases (37%) at the discretion of the reviewing cytopathologist, and results were reported as "no malignant cells identified," "atypical," "suspicious cells present," or "positive for malignant cells." The clinical results of the cytomorphologic examination were used for calculating sensitivity and specificity.
Follow-up Criteria
For the purposes of this study, an effusion was considered to be malignant on the basis of a combination of clinical, pathologic, and radiologic data. These included the following: strong clinical suspicion of a malignant process; repeatedly unexplained effusions; prior or future pathologic evidence of serosal malignancy (from biopsy or cytology); strong radiologic evidence of pleural, peritoneal, or pericardial involvement by a malignant process; and the absence of a concurrent benign explanation of effusion.
Exclusion Criteria
Effusions caused by a nonepithelial malignancy (eg, lymphoma, mesothelioma, thymoma, angiosarcoma, or germ cell tumor) were excluded from the analysis because the Ber-EP4/CD45/CD14 flow panel is not designed to detect them. Although excluded from sensitivity/specificity calculations, effusions from patients with nonepithelial malignancies (mesotheliomas, lymphomas, thymomas, or germ cell tumors) showed no significant Ber-EP4 expression. For example, the percentages of Ber-EP4–positive cells in effusions resulting from mesotheliomas were 0.06%, 0.21%, 0.34%, and 0.048%, which are all considered negative by our criteria. Peritoneal washings from women with benign ovarian and uterine conditions always contained small numbers of Ber-EP4–positive cells. The origin of Ber-EP4–positive cells is most likely exfoliated endometrial, tubal, and ovarian surface epithelium. The presence of Ber-EP4–positive cells in peritoneal washes is an artifact of the washing procedure and not a spontaneous occurrence. Hence, peritoneal washings were excluded from analysis.
Statistical and Sensitivity/Specificity Calculations
For sensitivity and specificity calculations, atypical and suspicious cytology results were considered to be negative because they are considered negative results by clinicians for practical decision making involving therapeutic interventions. The Fisher Exact t test was used to assess statistical significance using GraphPad prism software (GraphPad, LaJolla, CA).
Benign and Malignant Effusions
A total of 195 effusions were analyzed with flow cytometry. Based on follow-up data, 83 fluid specimens were judged to be benign and 76 malignant. Benign effusions Figure 1A were due to cirrhosis, congestive heart failure, acute renal failure, end-stage renal disease, hypoalbuminemia, surgery, chemotherapy, infections, and trauma. In some cases, the cause of the benign effusions could not be conclusively determined ("miscellaneous"). Malignant effusions Figure 1B were due to breast cancer (ductal and lobular), lung cancer (adenocarcinoma, squamous cell carcinoma, and mesothelioma), ovarian cancer (papillary serous), uterine cancer (endometrial carcinoma, carcinosarcoma, and adenocarcinoma), colon cancer (adenocarcinoma), gastric cancer (adenocarcinoma), renal cancer (renal cell carcinoma), bladder primary (transitional cell carcinoma), and hematologic malignancy (lymphoma). For some cases, a definite primary cause could not be determined from pathologic or clinical data ("miscellaneous"). The distribution of benign and malignant effusions is consistent with that observed in a tertiary care center.1
Flow Cytometric Gating Strategy
An unbiased initial gate is needed to capture malignant epithelial cells because they can widely vary in size and cytoplasmic content. Hence, all collected events were broadly gated in the forward vs side scatterplot, excluding only the dead cell debris and air bubbles at the edges Image 1A (gate 1). Singlet events that lie in the diagonal of the forward scatter area vs forward scatter height plot were then gated (Image 1A, gate 2).13 This gate excludes small clusters of malignant epithelial cells that can confound analysis of signals from single cells in other channels. Cells of hematopoietic lineage, including lymphocytes, monocytes, and macrophages/histiocytes, all of which express CD45, were gated out in the CD45 vs CD14 plot (Image 1A, gate 3). The only cells remaining in the analysis represent mesothelial cells and Ber-EP4–positive epithelial cells (if present). The proportion of Ber-EP4–positive cells was then calculated as a percentage of the total CD45 and CD14 double-negative population (Image 1A, gate 4). This value was used for further analyses. The presence of more than 0.5% CD45-negative, CD14-negative, Ber-EP4–positive cells was determined to indicate a malignant effusion. This negative cutoff for Ber-EP4 was based on fluorescence minus one controls and background staining in benign effusion samples. Back-gating analysis confirmed that Ber-EP4–positive epithelial cells vary in size and cytoplasmic content and are widely distributed in the forward vs size scatterplot Image 1B.
Ber-EP4 as a Marker of Epithelial Carcinomas
A wide variety of epithelial carcinomas were detected with Ber-EP4 flow immunophenotyping Image 2. Ber-EP4 expression on flow cytometry and immunohistochemistry on the cytology cell block preparation showed good correlation despite the additional filtering step for flow cytometry preparation that removes large clumps to prevent clogging of the flow cytometer. Data from a malignant peritoneal effusion from a primary ovarian papillary serous adenocarcinoma are shown Image 3A. Flow cytometry showed that 10.5% of the CD45- and CD14-negative population and 2.62% of total cells in the effusion expressed Ber-EP4. A similar proportion of cells were positive on Ber-EP4 immunohistochemistry. The other CD45- and CD14-negative cells are presumably mesothelial cells. Data from a malignant pleural effusion caused by an adenocarcinoma are shown Image 3B. Ber-EP4 expression was seen in 0.99% of the CD45- and CD14-negative population and 0.21% of the total cells in the effusion. A similar proportion of cells were positive on Ber-EP4 immunohistochemistry.
Flow Cytometric Immunophenotyping of Malignant Effusions
Significant numbers of CD45-negative, CD14-negative, Ber-EP4–positive cells were detected with flow cytometry in 89.3% of malignant effusions Figure 2A. The sensitivity and specificity of flow cytometry was 88.15% and 97.64% compared with 73.68% and 100% with cytology for the presence of epithelial cells in a malignant effusion. Flow cytometry had a positive predictive value of 97.1% and a negative predictive value of 90.2% compared with cytology, which had a positive predictive value of 100% and a negative predictive value of 80.58%. The difference between flow cytometry and cytology for a "positive for malignancy" diagnosis was statistically significant (Fisher exact t test; P = .0378). Benign effusions had very few CD45-negative, CD14-negative, Ber-EP4–positive cells whereas malignant effusions showed significantly larger numbers of CD45-negative, CD14-negative, Ber-EP4–positive cells (Figure 2A). The proportion of CD45-negative, CD14-negative, Ber-EP4–positive cells in benign effusions was less than 0.5% (background staining). An effusion was considered malignant if it contained greater than 0.5% of CD45-negative, CD14-negative, Ber-EP4–positive cells. However, the qualitative nature of the Ber-EP4–positive population (presence of a cluster and intensity of signal) was also taken into consideration for the decision in certain unusual cases. If a specimen contains a large number of mesothelial cells relative to malignant epithelial cells, then the CD45-negative, CD14-negative, Ber-EP4–positive proportion could be lower than 0.5%. Data from a recurrent malignant pleural effusion in a patient with a history of ductal carcinoma of the breast are shown Figure 2C. The proportion of CD45-negative, CD14-negative, Ber-EP4–positive cells is only 0.42%, but the presence of many cells that occur in clusters with intermediate to high Ber-EP4 staining indicates a true malignant effusion. Conversely, in paucicellular specimens, nonspecific staining can artifactually increase the proportion of Ber-EP4–positive cells. An example of a benign effusion with a Ber-EP4–positive proportion greater than 0.5% are shown Figure 2D, in which most of the Ber-EP4–positive staining is of low intensity, which exclusively lies just above the negative control line and hence is not indicative of true Ber-EP4 expression. In addition, as is standard in flow cytometry, events that occur along the diagonal axes in every dot plot are likely dead cells and should be excluded. Hence, the presence of malignant epithelial cells in an effusion cannot be determined on purely quantitative criteria but should always be made in conjunction with qualitative criteria.
Discordant Results Between Flow Cytometry and Cytology
In 11 cases, flow cytometry identified significant numbers of malignant epithelial cells, whereas the cytology findings were not considered positive for malignancy. In these cases, a different (prior or subsequent) cytology specimen or subsequent surgical biopsy specimen was positive for malignancy. In such cases, a review of the cytology slides and a Ber-EP4 immunostain were performed. In some cases (n = 6), epithelial cells were present but overlooked because they were either rare occurrences in hypocellular cytologic preparations or because there were too many obscuring RBCs, mesothelial cells, or inflammatory cells. Image 4A illustrates a pleural effusion in a patient with primary lung adenocarcinoma. The cytologic preparations were hypocellular and bloody and interpreted as negative for malignancy. Flow cytometry showed significant numbers of CD45-negative, CD14-negative, Ber-EP4–positive cells. A Ber-EP4 immunostain performed subsequently on the cell block preparation showed rare Ber-EP4–positive malignant epithelial cells. Radiologic evidence showed pleural involvement by malignancy, and a subsequent pleural biopsy specimen was also positive for adenocarcinoma, proving that effusion was most likely a true malignant effusion. Image 4B illustrates another such case—a new peritoneal effusion sampled in a patient with a uterine mass. Cytologic preparations were hypocellular and interpreted as negative for malignancy. Flow cytometry showed significant numbers of Ber-EP4–positive cells. Ber-EP4 and PAX8 (not shown) immunostains highlighted rare epithelial cells of müllerian origin. A subsequent laparotomy revealed widespread peritoneal metastases, and a peritoneal biopsy confirmed involvement by endometrial adenocarcinoma. In these cases, concurrent flow cytometric analysis increases the detection of malignant epithelial cells in the clinical sample because they were missed on cytologic examination alone.
Five of the cytologic false-negative cases were reported as atypical (n = 1) or suspicious (n = 4) because the specimens showed rare, poorly preserved atypical cells. In these cases, flow cytometric analysis detected significant numbers of epithelial cells (>0.5%). Here again, concurrent flow cytometric analysis increases the detection of malignant epithelial cells in the clinical sample and could enable a cytology result of atypical or suspicious to be reclassified as positive.
Two cases were falsely positive on flow cytometry. Both cases showed a borderline proportion (around 0.5%) and low-level expression of CD45-negative, CD14-negative, Ber-EP4–positive cells. Cytology was suspicious in one of these cases and negative in the other. Although cytology had no false-positive cases, 3 cases that were called atypical/suspicious were negative using gold standard criteria. Flow cytometry was clearly negative in 2 of those cases. It is possible that the interpretation of flow cytometry results in conjunction with cytology can eliminate potential false positives. Finally, 8 effusions were negative on both flow cytometry and cytology for malignant cells but were considered malignant effusions using the gold standard follow-up criteria. Some of these cases could represent minimal/focal involvement of the serosal membrane by the tumor. It is also possible in at least some of these cases that the effusion was due to indirect effects of a tumor, such as lymphatic blockage or irritation of serosal surfaces.
We have demonstrated that simple, rapid, 3-color flow cytometric immunophenotyping using Ber-EP4 can be used to detect malignant effusions. Because Ber-EP4–positive cells do not naturally occur in effusions, their detection with flow cytometry can be a useful adjunct to cytology for the diagnosis of a malignant effusion when sufficient numbers of Ber-EP4–positive cells with high levels of expression are detected. The sensitivity and specificity were 88.15% and 97.64%, respectively, with flow cytometry compared with 73.68% and 100%, respectively, with cytology for the presence of epithelial cells in a malignant effusion. We showed that flow cytometry is particularly useful if the cytologic diagnosis is atypical/suspicious or if the cytologic preparations are hypocellular and hemorrhagic. We found 11 cases in which flow cytometry identified significant numbers of malignant epithelial cells but the cytologic results were falsely negative. Of these 11 cases, 5 were called atypical (n = 1) or suspicious (n = 4) and 6 were called negative. Although the clinical usefulness of flow cytometry in those 6 cases is clear, we believe that flow cytometry is clinically useful even in the 5 atypical/suspicious cases because it detected significant numbers of epithelial cells in all those cases. One explanation is that cytologic preparations are limited by the number of cells on the slide, whereas flow cytometric immunophenotypic analysis takes into account all cells in the sample. Flow cytometry is inherently quantitative, and the number of Ber-EP4–positive cells detected can be used as additional information to improve diagnostic accuracy. This information can potentially decrease the number of atypical/suspicious diagnoses rendered because of paucity of cells.
We considered atypical/suspicious cases seen on cytology as negative for statistical calculations because they are considered to be negative by clinicians for practical decision making involving therapeutic interventions. If the atypical/suspicious cases on cytology are considered to be positive, the sensitivity of cytology would increase but its specificity would decrease. In many of the atypical/suspicious cases seen on cytology, flow cytometry was clearly negative or clearly positive and hence would add clinical value if concurrently performed.
We used a novel gating strategy to accurately identify epithelial cells in contrast to previous studies.6,8,12 Back-gating of Ber-EP4–positive cells revealed that many malignant cells were in the lower ends of the axes near the region usually occupied by cell debris. This region is gated out during routine flow cytometric analysis. Malignant epithelial cells are fragile and fragment during the sample preparation. Hence, it is important to use a broad initial gate to include even fragmented cells to improve sensitivity. These cells do not nonspecifically pick up other antibodies and do not appear in the diagonal region of flow cytometry plots, thus suggesting that they are not nonspecific debris or dead cells. However, preparing cells for immunophenotyping on ice with gentle manipulation might keep the malignant cells intact and reduce the presence of such events. A forward scatter area vs height plot is then used to gate on singlet events.13 The gate is important to exclude multiple signals that can potentially arise from cell aggregates in other channels. Cells of hematopoietic lineage were excluded by gating CD45- and CD14-positive events. This gate isolated mesothelial cells and epithelial cells for further analysis. It is interesting to note that CD45 and Ber-EP4 double-positive events often occur. This phenomenon has been seen and described in the circulating tumor cells.14 These are probably Ber-EP4–positive cell fragments that adhere to CD45-expressing cells. Our gating strategy excludes such events by gating out all CD45-positive cells.
In contrast to previous studies that relied on purely quantitative criteria, we used a combination of quantitative and qualitative criteria to infer the presence of a malignant effusion.6,7,12 As a first step, we used a 0.5% level of Ber-EP4 expression to separate benign from malignant effusions. However, the level of Ber-EP4 expression that distinguishes a benign from a malignant effusion depends on a number of factors such as the antibody conjugate used, flow cytometric panel used, number of cells collected, gating strategies, and instrument settings. Hence, such cutoffs should ideally be standardized by every flow cytometry laboratory. In spite of standardization, it can sometimes be truly difficult to differentiate background Ber-EP4 staining from true low-level Ber-EP4 expression in a tumor or presence of benign epithelial cells. In those cases, correlation with cytology findings and clinical data will help arrive at the correct diagnosis.
A recent study by Kentrou et al7 demonstrated high sensitivity and specificity with this technique, but their use of a complicated 3-step protocol requiring 18 flow cytometric antibodies/reagents for every effusion limits the everyday use of their technique. Our study was able to achieve similar results with 3-color flow cytometry and without the need for an additional permeabilization step.
One caveat of our study is the reliance on Ber-EP4 expression as a marker for all epithelial malignancies. It is possible that some poorly differentiated epithelial tumors downregulate Ber-EP4 expression. Additional markers for epithelial cells might be helpful in such situations.15 Rarely, Ber-EP4 expression is also possible in atypical/reactive mesothelial cells. Markers of mesothelial cells, such as WT-1 or calretinin, can be used to identify and exclude such cells from the analyses. However, antibody conjugates of epithelial and mesothelial markers are not commercially available and would need to be made by the flow cytometry laboratory.
It is important to note that flow cytometric immunophenotyping in its current form detects the presence of epithelial cells in the effusion and cannot conclusively determine whether the cells are benign or malignant. Cytomorphology examination is the current standard for that determination. A proliferation marker such as Ki-67 or DNA content analysis for aneuploidy can be used in flow cytometry to differentiate a benign epithelial cell from a malignant cell7,16 and could be combined with the current approach. Reactive mesothelial cells can show a high proliferation index or aneuploidy, but they should be gated out using mesothelium-specific markers. Using DNA content in isolation without using lineage-specific markers did not improve specificity.7,8,12
Another interesting observation is the frequent presence of Ber-EP4–positive cells in peritoneal washings. The likely origin for such cells is exfoliation of ovarian, tubal, or uterine epithelium. It is conceivable that epithelial proliferations like endometriosis that involve the peritoneal cavity can be a source of benign epithelial cells in peritoneal effusions. Recent surgery in the peritoneal or pleural cavity can also theoretically result in the presence of benign epithelial cells in effusions. However, such cells have low-level expression of Ber-EP4 and occur in much lower numbers compared with malignant epithelial cells in effusions. Previous studies have included peritoneal washings in their analysis, which was probably responsible for their higher false-positive rate.6,9
A major advantage of flow cytometric immunophenotyping is that panels can be scaled up to gather additional data as needed. Additional markers in a flow panel can also determine the tissue of origin of the neoplasm. In this era of personalized medicine, additional patient-specific data can be determined with flow immunophenotyping of effusions. Hormonal status (estrogen and progesterone receptors) and Her2 status in metastatic breast carcinomas17,18 or BRAF mutation status (through use of mutation-specific antibodies) in metastatic lung carcinomas can be determined in effusions.19–22 Highly purified tumor cells can also be isolated by fluorescence-activated cell sorting for subsequent use in molecular diagnostics. Similar strategies can also be used to detect and phenotype malignant epithelial cells in lymph nodes, peripheral blood, and bone marrow specimens.23,24
Upon completion of this activity you will be able to:
describe the expression of Ber-EP4 (EpCAM) in different cell types and malignancies.
apply quantitative and qualitative flow cytometric data to distinguish between a benign and malignant effusion.
compare the advantages of flow cytometry and cytomorphology in the evaluation of serous effusions.
The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™ per article. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity qualifies as an American Board of Pathology Maintenance of Certification Part II Self-Assessment Module.
The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
Questions appear on p 692. Exam is located at www.ascp.org/ajcpcme.
- © American Society for Clinical Pathology


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Jodi Morris's lifelong ties to the National Park Service
"History is always happening" at Little Rock Central High School National Historic Site
DPA, Ross, Pryor, their owners must be funding all sides of this. Just like national Democrats and Claire McCaskill funded their wingnutty "opponents".
There is no potential win for the constitution, rule of law (especially at the top), the economy or the 99 percent in any AR race we know of so far.... that is yet again the feature of this entirely corrupt bribe based political/electoral system.
It's like watching the Sopranos on thorazine.
lessor of two evils my as*.
Here's a few reform suggestions.
Throw out the entire tax code. Begin anew.
Tax the rich like it's 1959! Start with the Walton siblings who have over 80,000 millions.... and the Kochs who have over 50,000 millions. Seize offshore havens with tens of trillions trillions hidden by the rich individuals and corporations. Use the military if need be.
Constitutionally outlaw any ability to dedicate tax streams to privateers. (Obamney not care)
If someone earns less than 40k a year... there is no tax. Exception for Social Security and Medicare for all.
The new progressively scaled tax code should be so simple and straight forward that everyone utilizes a form as simple as the 1040EZ. It should be the ONLY tax form for all individuals. Otherwise "I don't understand" should be such an acceptable excuse it triggers automatic immunity from prosecution for evasion
Most of all quit pretending ponzi schemers and their bribed/bought snake oil salesmen in either party are anything but part of the criminally corrupt problem. Obama, Max Baucus? Come on, Max! Negotiating with the devil may make for good copy, but the Game of Thrones should be a warning not a road map.
I guess this means all those electric lines are now buried, hundreds of thousands of homes are now semi-solar connected to the grid and that AR Nuclear One holocaust is fully decomissioned.
Or that the CEO is due for a raise.
Oh my... there is a zombie, I mean a DPA. It spoke, without a spine. How many months after a spill? Asking that old Exxon fox to report on it's bloody henhouse management report again.
That will show 'em!
I hope you have a bottle of dramamine handy after all the deceptive spin you repeatedly have to perform in order to justify your neoliberal TINAism (there is no alternative).
Lower eligibility of expanded medicare to date of birth and negotiate prices, especially of drugs. Health care for all, no matter their circumstance for half the GDP we spend today. Can be done in a year with existing one page 20 year old bills submitted in the U.S. House.
It's so simple even you down there in the bottom land should be able to see it... but your paycheck must depend on it never happening.
You Obamacratic neoliberals should be ashamed of yourselves for giving the republicans everything Bob Dole to Mitt Romney ever wanted. And you should quit expecting republicans to ever be satisfied. That's not in the divide and conquer American kabuki playbook.
You are already far right as Dole Romney... and that was obviously wrong for decades.... Letting these kabuki events compel you to defend Obamney not care is worth trillions to the sponsors/ looters, while millions go without care and hundreds of millions pay way, way too much.... Suckers.
Ted Humko rendered.
Arkmom, that is not her job. Her job is the law of the state of…


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They got us into this mess | LETTER TO THE EDITOR
To the editor.
Mr. Holmes is correct, the numbers pertaining to the trip to India were inflated.
Not by myself. The intent was to draw attention to the excesses surrounding trips by Obama, Reid, Pelosi and others, at taxpayer expense.
Current economic conditions demand that our nation's leaders set a good example. Vacations in Hyannis Port and other expensive locations, tours of various golf courses, etc. highlight the extravagant behavior this current administration pursues. Madame Pelosi is a "poster child" for wasting taxpayers' money by demanding an Air Force jet to fly her hither and yon. No small plane for her! The liquor bill she has run up is well over a million dollars while she and family members travel royally, all at our expense.
Congratulations to Rick Larsen and Patty Murray for their next terms in office where they can vote themselves, and all of Congress, another 3-percent raise, just like the current one in the budget. Of course, those on Social Security gladly gave up their COLA so Congress would not suffer.
Are we to believe the inflated numbers of new jobs created by the "stimulus"? Oddly enough, they are not in the private sector. The jobs are in government. Oh my, how generously those are endowed. The number of government employees who earn $150,000 per year (plus perks) has nearly doubled. That really makes the economy grow. Not yours, stupid. No, those poor deserving slaves in DC and other bastions of regulatory control who try so hard to look busy. Imagine this, on a public servant's salary they could become millionaires. After all, it is possible. Currently 40 percent of those in Congress became millionaires on public salaries. Amazing.
Please congratulate yourselves on re-electing too many of those who got us into the mess we are in. You deserve it.
Robert Turner
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James is the co-chair of the IUCN SSC Climate Change Taskforce and has recently been elected the global president-elect of the Society for Conservation Biology. He is a Honorary Associate Professor in the School of Biological Sciences at the University of Queensland.
He is currently Director of the Climate Change program for the Wildlife Conservation Society, based in New York. James oversees WCS efforts on climate change adaptation and mitigation. The climate adaptation team provides technical expertise and helps incorporate anticipated impacts of climate change into the planning and implementation of conservation projects throughout WCS's landscapes, seascapes, and species conservation programs. The climate mitigation team overseas diverse portfolio of REDD+ demonstration projects around the world and works to ensure that these inform the design of REDD+ systems through UNFCCC negotiations, national REDD+ readiness processes, and voluntary certification standard.
They work throughout WCS's landscape, seascape, and species conservation programs in Africa, South America, Oceania, Asia and North America. The team also works with governments, multilateral institutions and private landholders to help promote the conservation of natural ecosystems as a cost-effective and practical means of addressing the impacts of climate change on humans and wildlife.
James began working with UQ as a postdoctoral fellow. In this role he worked closely with different government agencies and environmental NGOs to prioritise conservation investment in different countries. James appointment as an Honorary Associate Professor at UQ in 2011 has allowed this research to continue and expand with his role at WCS.
Brief CV
James is a graduate of the Australian Defence Force Academy and Royal Military College. He completed his doctorate at the Oxford University in 2004, where funded by a Rhodes Scholarship he explored the effects of habitat fragmentation on birds in Madagascar and Australia. Since then, he has worked as a post doctoral fellow at the University of California (San Diego) and as a senior campaigner for The Wilderness Society in Australia.
About the Wildlife Conservation Society
Founded in 1895, the WCS has the clear mission to save wildlife and wild places across the globe. Its story began in the early 1900s when it successfully helped the American bison recover on the Western Plains. Today, it protects many of the world's iconic creatures, including gorillas in the Congo, tigers in India, wolverines in the Yellowstone Rockies, and ocean giants.
Since its founding, WCS has forged the power of its global conservation work and the management of its five parks in New York City to create the world's most comprehensive conservation organization. It currently manages about 500 conservation projects in more than 60 countries, and educates millions of visitors at five institutions in New York City: the Bronx Zoo, New York Aquarium, Central Park Zoo, Prospect Park Zoo and Queens Zoo.


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Indian cuisine is renowned for its fiery flavours. What are your top five tips for dowsing the flames?
You know, much Indian food is not that spicy. But the reason that an Indian kitchen serves many dishes with raita – a yoghurt sauce typically mixed with various things like cucumber, mint, tomatoes – is to balance and cool a dish that might be spicy. You can add as much or little as you want. Also, often a sweet chutney is used for that same purpose. It's a very thought-out cuisine with balance and smart decisions.


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I think it is worth the money.
I see an offer for a wii that reads.
"Nintendo Wii Original packaging, instructions, box, cables, and wires. Hardly used, in great condition. Comes with one wii remote, one nunchuck, and 2 plastic covers for wii remote. Also comes with 3 games : Madden 08, Zelda Twilight Princess, and Wii Sports (5 games in 1) Still rare to find, asking $300" Good deal?
I think it is worth the money.
good deal, the only things that are kind of different about a 250 wii are the two games which together would = up to 350 or so. . and the plastic covers are free if those were wiimote jackets.
Mario Kart DS 438194819390
People i respect on this forum: Atomic,Santa Claws,Frogger,Cyan,Levesque, Balrogs.pain, Shoko, MushroomedMario, sremick
I make my avatars/signatures!
Spoiler Alert!For some reason, i only have WiiSports, But whats weird is my friend lets me borrow his games so i dont have to waste money.
BLASPHAMYOriginally Posted by levesqueking
Mmm nice deal I think.
Mod Edit: Image removed. Some users may find it offensive and inappropriate.
SSBB FC: ????-????-???? (New Wii, so I gotta check)
Gamertag: T3kNi9e
Been playing alot of WarCraft III lately, anyone up for game? Just message me, my account is the same as here and GT.
I think that sounds good!
possibly if you're really itchy for one.
get proof of age for warranty purposes... & if shipping is reasonable... i keep all my packaging to everything and i think it represents how well i take care of my equipment...
see this thread to see if patience and persistance can pay off for a new one
i know they're rare, but don't give up.
Last edited by gidget; 02-08-2008 at 09:23 PM.
Thanks for the replies people. I'm sorta getting desperate for one and it's the best deal i've seen so far. They're so hard to find around here, like no place gets them, and when they do get them, they're always sold out with in an hour. So probably if I said like 250, he would probably get insulted?
not really they may just laugh. it's worth a shot... there's a few games included...
Think of it this way...for $300 you're basically getting a free game. Just be sure you're confident that this unit was treated well and that those games are games you want...otherwise, I'd hold out for a new one.
However, if it was me, I would wait for a store to get one in...I like knowing that I was the only owner
Games Owned: Wii Sports, Wii Play, Legend of Zelda: Twilight Princess, Super Mario Galaxy, Mario Strikers Charged, Metriod Prime 3 Corruption, Super Smash Bros Brawl
Wanted games: Mario Kart Wii, Super Paper Mario, Resident Evil 4, Zack & Wiki, Endless Ocean
where are u looking at this on ebay??? does it say buy now or still bidding and how much is shipping?
Chips from fight klub


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Lavie Tidhar's 'Osama,' 'The Weird' anthology win World Fantasy Awards
Lavie Tidhar's 'Osama' was voted the year's best fantasy novel this weekend at the World Fantasy Convention in Toronto. It won over stiff, worth competition that include Jo Walton's "Among Others," which had already won this year's Hugo and Nebula Awards; George R.R. Martin's "A Dance With Dragons," the latest installment in his "A Song of Fire and Ice" series; and Stephen King's "11/22/63," a popular and bestselling Kennedy assassination time-travel tale.
Tidhar is an Israeli-born writer who now lives in London. i09.com's Charlie Jane Anders described his novel as "a strange pulp-oriented alt history about Osama Bin Laden." »Read Full Blog Post(1)
United Performing Arts Fund raises record $11.7 million
The United Performing Arts Fund raised a record-setting $11,728,476 this year, more than $700,000 more than last year.
The results of this year's campaign, which supports the core operating costs of area performing arts groups, were announced at a wrap-up event Thursday night presented by Potawatomi at the Milwaukee Repertory Theater's Quadracci Powerhouse Theater. »Read Full Article
Tickets go on sale Friday for Alton Brown at the Riverside
Food-science geek Alton Brown, a cookbook author and host of "Good Eats" on the Cooking Channel and "Iron Chef America" on the Food Network, is making a stop at Milwaukee's Riverside Theater on Feb. 14.
His Edible Inevitable Tour is billed as a family-friendly show that will include musical numbers, mostly written by Brown, food experiments and a multimedia talk. »Read Full Blog Post
Barrett keeps up pressure for higher Summerfest payments
With Summerfest less than three weeks away, Mayor Tom Barrett is renewing his efforts to press officials operating the world's largest music festival to pay more for police and fire services.
Under an existing lease between Milwaukee World Festival Inc. and the Board of Harbor Commissioners, Summerfest paid $1.3 million in rent last year. »Read Full Article(18)
Vampire Weekend's live show doesn't match depth of albums
Vampire Weekend makes pretty great songs and albums. Vampire Weekend puts on a pretty good show.
The gap between isn't cavernous, but there is a distinction — enough so that Weekend's Wednesday night concert at the BMO Harris Pavilion on the Summerfest grounds, while fun, was still a bit disappointing. »Read Full Article(4)
Behind the costumes on Cher's 'Dressed to Kill' tour
Hugh Durrant's client: the one and only Cher.
His predecessor: the beloved Bob Mackie. »Read Full Article(1)
'For No Good Reason' captures gonzo artist Ralph Steadman
Muppetologically speaking, The Great Gonzo is a "whatever," but surely he shares the gene for death-defying creativity with Ralph Steadman, the progenitor of gonzo art and a visionary in any phylum, class or order.
"For No Good Reason," a new documentary by Charlie Paul, doesn't waste time attempting to categorize Steadman, whose spectrum of cartoon mayhem famously contains the jet-black bats that divebomb the pages of Hunter S. Thompson's "Fear and Loathing in Las Vegas." »Read Full Article
Milwaukee R&B singer makes connection with rapper Ace Hood
If R&B success was based on physique alone, Milwaukee native Darryl Hatcher, a.k.a. D Lux, would have it on lock.
"I work out four to five days a week. You could call me a workout addict," said the buff D Lux, 24. »Read Full Article(1)
Tom Cruise gives 'Edge of Tomorrow' an edge
Action and science-fiction movies are the only genres big enough to hold Tom Cruise, which is why he gravitates toward them.
He is an incredibly athletic actor, gleefully does many of his own stunts — that's probably actually him every time he rides a motorcycle onscreen. Common to his movies are titles produced by a random name generator. Last time it was "Oblivion." This time, it's "Edge of Tomorrow." »Read Full Article
This week's concerts
7:30 p.m. Tuesday and Wednesday, Pabst Theater, 144 E. Wells St. $44 to $60 at the box office, (414) 286-3663 and pabsttheater.org. »Read Full Article
Milwaukee movies off the grid: June 6-12
Some alternate movie offerings around the Milwaukee area:
Paul's Alley Cinema
"Picnic": With a heavyweight cast including William Holden, Kim Novak, Cliff Robertson and Rosalind Russell, this 1955 classic ain't no, well, picnic — just lots of intense, 1950s melodrama. The outdoor screening starts at 8:40 p.m. Free. »Read Full Article
On Tap Today: Kandinsky, Downtown Dining Week, Big Gay 5K
It's that time — your monthly chance to experience the Milwaukee Art Museum at no charge. It's also opening day for the museum's latest installation: Kandinsky: A Retrospective. See what Journal Sentinel art critic Mary Louise Schumacher has to say about the exhibit.
Downtown Dining Week begins today. You can get a prix fixe lunch for $12.50 or dinner for $25 or $35 at a variety of popular restaurants in downtown Milwaukee. Make sure to call first to make a reservation or see if there's availability. You have until June 12 to try as many menus as you can before the deals end. »Read Full Blog Post


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Doctor insights on:
Black Line On Toenail Causes
What causes black toenail?
Blood,fungus,other: The most common causes of black toenails are old blood from trauma and fungal infections. There are other dermatological and hematological causes, but they are not common. ...Read moreSee 2 more doctor answers
Toenails (Definition)
Toenails are the hard coverings at the end of the toes. Nails are made out of a protein called keratin. They function to protect the end of the toe and to increase sensitivity of touch. Good nail care is important to prevent ...Read more
What causes black lines in the toenails?
Various things: In people with skin of color it may be a normal variation. Skin growths may also cause them, both of the benign and malignant kind. See your dermatologist. ...Read moreSee 1 more doctor answer
What causes black and blue toenails?
See a podiatrist: If you are runner, this is a common injury called "black toe syndrome" due to blood bruises under the nail plate. Other causes of black toenails are infections - either bacterial or fungal. Another cause may be from a fracture in the last bone of the toe. In any case, see a podiatrist who can examine and treat any of these conditions and recommend ways to prevent recurrence. ...Read moreSee 1 more doctor answer
What can cause black/purple toenail root?
Injury: Usually some time of injury will cause discoloration due to bleeding under the nail. ...Read more
I'm 37, black and a weightlifter. I hurt my big toenail last year. It fell off. Now, i saw 2 or 3 faint streaks in the part growing back. Is there any cause for concern?
Probably not: Discoloration of a nail after trauma isn't unusual. As long as the mark moves and is replaced by clear nail, it generally isn't a concern. ...Read moreSee 2 more doctor answers
What causes an ingrown toenail after surgery to go black on the border of the toenail left?
Chemical burn...: or dried blood from the procedure is the most likely culprit ...Read moreSee 1 more doctor answer
What could be the cause of vertical black lines in finger and toenails? I had a nurse tell me it could mean heart problems but after listening to my heart said it sounded normal.
Please : Please see a dermatologist. It could just be melanonychia due to increased pigmentation, but a skin cancer called melanoma can also present with streaks. You may need a biopsy. ...Read more
My husband has a toe nail that is rotten & black & the nail is coming off , what could be the cause ?
Most likely Fungus: This sounds like a fungal infection of the toenail. There are various treatment options. Topicals don't work well, but may if you are aggressive with treatment. Oral medication may be needed. This conditiion may be caused by repetitive trauma. Have him see your local podiatrist for evaluation and treatment options. Dr l. ...Read moreSee 2 more doctor answers
About a month ago half my toe nail turned black. It hasn't gone away or even lessened. What's the cause and how to get back to normal color?
Dry blood: It is very common to have bleeding under the toenail without an injury. Everyday walking causes pressure from the toenail hitting the shoe, which can cause tearing of the nail plate from the nail bed which will make the nail look black. In most cases this is self-limiting. However rarely this can be melanoma And needs to be evaluated. ...Read more
Can paint thinner cause black toe nails?
It can contribute: Pain thinner directly would not cause the discoloration but thinning out of the nail plate due to the chemicals could cause the toenails to become vulnerable to infection by fungus, yeast or bacteria. ...Read more
- Talk to a doctor live online for free
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You were thrilled to enter the crawl space, but also frightened. There was a chance of snakes.
Staying in challenging relationships
I could stay home on Sundays when visiting my parents. But I return to the pews of my childhood church because I love the people despite our differences.
All I remember from The Magic Stones is the image of a young man, some stones and blocks, and an experiment revealing the most perfect shape.
Spring books
In her 11th novel Toni Morrison returns to the foundation of most of her fiction: childhood and its traumatic effects.
In the fifth row first seat there was a slight boy named Matthew. He could not sit still under any circumstances whatsoever.
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How bad is the West Virginia defense? Well, they're the biggest reason this Mountaineer team hasn't made a very smooth transition to the Big 12 Conference. They're also the reason this team has l...
If you cant say something nice, dont talk WVU defense
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For Craig Finn, Rock and Roll is Church
As leader of The Hold Steady, Craig Finn has never been at a loss to find ways to pepper his musical odes to youthful indiscretions and offbeat characters with a dose of lyrical holy water. Not that Finn has used his tunes as a pulpit to preach; he's merely employed his time spent in church as a well from which to draw more color for his characters.
On "Stuck Between Stations," from The Hold Steady's 2006 album Boys and Girls in America, Finn sings, "She was a really cool kisser and she wasn't all that strict of a Christian. She was a damn good dancer, but she wasn't all that great of a girlfriend." The heartache and disappointment in that snippet is that of a boy who thought his own Christian ties might finally give him the inside track to the youth group's hottest girl, only to realize he had once again lost out to the bad boys who had the fun he wasn't supposed to.
Christianity's role in Finn's music has continued to show itself with the release of his first solo album, Clear Heart Full Eyes. It's refreshingly honest in terms of how faith and church work their way into his artistic consciousness.
Craig Finn
Craig Finn plays Wednesday,February 1, at Club Dada. Mount Moriah open.
"I was raised in a family that, while not super-religious, still went to church every Sunday," Finn says as he prepares for a round of solo dates in the U.K. "I think religious themes and references end up in my songs because I seem to go back and forth with it all. I will go to church for a while, then I stop. There are parts of the Catholic church I agree with, and there are parts I'm not so enthralled with. The way I'm so on and off with it all is why it keeps getting into my songs."
Upcoming Events
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TicketsThu., Oct. 27, 8:00pm
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TicketsFri., Oct. 28, 7:00pm
- Straight No Chaser
- Evanescence
When speaking of a higher power or a supreme being — whether in support of one or questioning the existence of one — many musicians take an abstract approach. Finn not only gives religion a matter-of-fact veneer within his storytelling, but in the case of Americana barn-burner "My Friend Jesus," he admits to discussing a very specific image of him.
"The Jesus I want to represent in that song, in many ways, is the human Jesus. The flesh and blood Jesus that lived on Earth and had personal struggles," he says. "We're all trying to be the best we can. Being Christian is trying to emulate Christ as much as you can, even if you can't do it all of the time."
While openly claiming faith and religion isn't exactly standard conversation surrounding a rock star's creations, Finn manages to cut through the labels and preconceived notions of those polarizing tags to address something that most everyone seeks at one point or another.
"The part that attracts me to church is the part where forgiveness is present," he says. "No matter what you believe in, we all have a place for forgiveness in our lives, and there's a beauty in the church that really interests me."
Given that Finn's writing often unfurls more as a novel or short story than a typical rock song, it's fitting he can easily reconcile those polar opposites.
"There's also a real parallel in the way a church service is conducted and the way a rock and roll show is. I like that, too."
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Release November 2011. Deep, concentrated garnet color. Cassis and wild cherry aromas with hints of fresh tobacco, sassafras, ocoa, and clove. Seductive, mouth watering and savory notes complement the fine tannins and lingering warmth on the palate
Please click on Image below to see full vintage details
And we're almost ripe and planning to pick next week. What makes "ripeness"? Read on!
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Comic, podcast-master Marc Maron to play Pabst Theater May 4
Stand-up comedian Marc Maron, whose talking-about-comedy podcasts have made him one of the medium's biggest and most connected performers, will bring his stand-up A-game to the Pabst Theater at 8 p.m. May 4.
Maron's podcast, "WTF With Marc Maron," averages 2.5 million to 3 million downloads a month, and helped him land a half-hour scripted series, "Maron," on IFC. The show will air later this spring. »Read Full Article
Milwaukee Art Museum will be free this weekend
The Milwaukee Art Museum's admission will be free on Saturday and Sunday from 10 a.m. to 5 p.m. This is to mark the opening of "30 Americans," a multi-generational art exhibit featuring the work of African American artists.
Many of the artists in the exhibit address issues of race and cultural identity in very direct ways, and the show is one of the first in the museum's featured exhibition space to explore such issues so directly. The museum has also placed "Wisconsin 30" an exhibit of 30 African American artists from the state on view. »Read Full Blog Post
New DVDs for release June 18
Milwaukee movies off the gridn June 14-20
Bike and a movie
The Milwaukee Bike-In Movie Series returns Friday with the 1989 John Candy comedy "Uncle Buck." »Read Full Article
Outdoor films return to lakefront
The Fish Fry and a Flick outdoor movie series returns to the lakefront Aug. 30 with a showing of the Marvel superhero action film "The Avengers."
The series will also show two adult-themed films, "Ted" on Sept. 6 and "Django Unchained" on Sept. 13. »Read Full Article
Kohl's hosts style session with Lauren Conrad for three Children's Hospital teens
Lauren Conrad, fashion designer, style expert and best-selling author, teamed up with Kohl's to treat three teens from Children's Hospital of Wisconsin to a celebrity styling session Wednesday night in Milwaukee.
The event took place prior to Conrad's book signing for the launch of Infamous: A Fame Game Novel, the finale to her The Fame Game series, at Boswell Book Co. »Read Full Blog Post(1)


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Brunch with Herbie: This does not suggest itself as a suitable title for a book documenting a lengthy interview with Herbert von Karajan. Dinner with Lenny? Somehow, for Leonard Bernstein, this will do.
Richard Burnett takes you inside Montreal's pop-culture scene with his (not always) gay blog Pop Tart... »
Brendan Kelly on the local film and television scene. »
Words & Music keeps you posted on the good, the bad and the ugly in the world of music. »
It always seems to be film festival season »
Pat Donnelly on local theatre and book news. »


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A German Start-Up Makes the Shipping-World a Village
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In order to get started with their forwarding services, the company Mailbox Germany from Merseburg has launched a Crowdfunding project at Indiegogo.
Merseburg, Saxony-Anhalt, Germany., April 30, 2014 - (PressReleasePoint) -
Hermann Hetzer, the founder of Mailbox Germany wants to overcome the last financial obstacles via crowdfunding before starting with the Online-Service Mailbox Germany. The goal is to raise the amount of €20.000,- between April 28 and May 28 on Indiegogo. For that reason an own video has been made, as well as various reward packages for supporters have been prepared.
"The world is a village" - Hermann Hetzer introduces the crowdfunding video and further explains what should actually be financed. From all over the world it will be possible to make orders from German dealers. Especially from those, that usually do not ship abroad.
The orders will be directed to a personal German delivery address in Merseburg and after a short stopover forwarded to the customer to any place all over the world.
However, a little more assets are needed before the service actually starts working. The crowdfunding will be carried out by Indiegogo, the main international crowdfunding platform, located in San Francisco. All the supporters, depending of the amount invested, will get different attractive compensations. These vary from a free annual subscription at Mailbox Germany up to a flexible solar panel and other gimmicks that will make the support tasteful.
If everything works according to the plan, Mailbox Germany will be set up this autumn. And the chances are promising.
Additional information about our Project:
Website: http://www.mailbox-germany.com
Facebook: http://www.facebook.com/MailboxGermany
Blog: http://blog.mailbox-germany.com
Crowdfunding: http://igg.me/at/mailbox-germany
international, business, shipping, shopping, mailing, Germany
Press Contact:
Mr. Hermann Hetzer
Am Saalehang 4MerseburgSaxony-AnhaltGermany06217
+49 (0)3461 4792148
Email partially hidden to block spam. Please use the contact form here.
Contact Mr. Hermann Hetzer
Copy this html code to your website/blog to embed this press release.
This press release is licensed under a Creative Commons Attribution 3.0 Unported License. Read full copyright information here.


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Calvin and Hobbes by Bill Watterson
- May 01, 2012
- From Beginning
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Comments (52) (Please sign in to comment)
When I was a kid a belt to the @$$ was policy.
But Calvin, kids like you need more of those things than almost anybody else, because otherwise you'll try to find loopholes in the policy.
No loophole , Calvin?
@gmartin997: Your generation may be "the sandwich generation": Your own parents may have dictated to you, but under new thinking of how to raise kids,you can't dictate to your own kids.
On the other hand, when you DO tell him something the first thing he says is "WHY?!"
A new policy is definitely in order; in this case, I'd recommend term life.At the rate Calvin's going whole life won't happen and the rates are cheaper for term.
Unfortunately, one can tell which kids were disciplined and which were not. Completely different mindset. Many women chose to have kids singly in my age group, combined with the psychobabble of no discipline and the party party party mindset.
As a result a portion of Gen Y has no self-discipline, don't respect the rights of others and since they've never been told no and had it meant when they actively rebelled, they are pretty messed up. Failures in life.
What irks me is when one of those who didn't discipline their kids says "I didn't spank, but my kids turned out ok" but it turns out their idea of OK is drug use, violence toward others and usually run-ins with the law. Sometimes jail time. How that is supposedly "OK" I do not know.
Okay what about us over disciplined kids?
My mom's top down obey me our else really backfired. I'm proudly nothing like her. She;d rip her hair out if she knew half of what I do.
But I have a stable job, my own house, and a girlfriend for almost 2 years. No kids which almost seems to vex her.
Maybe that's why we survived no seatbelts, steel dashboards, standing up riding in the front seat with dad, no bike helmets or knee and elbow pads. etc. and today's kids can't brush their teeth without an electric brush and bottled water. New thinking. I honestly don't get concepts like a hands-free soap dispenser when you're about to wash your hands anyway. There is such a thing as overprotection.
OK, so you've succeeded in becoming a rebel and have your own life now. Suppose the unthinkable happens and you become responsible for raising a child of your own. Are you qualified? How would YOU handle it? History proves it can and does happen, after all, and kids are all unique and don't come with manuals. Are you prepared to handle it?
I honestly don't see why not.
Linus's attempt to limit Lucy's speech was also unsuccessful:
Click here: Peanuts (1964)
Snoopy had better luck with Woodstock:
Click here: Peanuts (1981)
Yea – we didn't have DYFUS around to protect us then.
Yes, me too. I'd love to use that one now, but maybe I'm better off not having children in this bleeding heart liberal environment.
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92. seflagamma8:15 PM GMT on January 24, 2012
Skye, that is too funny, I guess D-Fly is just a few months older than Baron.
I remember when D-Fly was born! I was the "WU relayer of the news" LOL
I love it when we can expose the young ones to places they can learn something. Sounds like fun.
Sandi, actually we have "cute a few curls off" before but never all of them at once.
But this time ... it was time..
Baron use to have a lot of curls, then he went short a few years.. now his hair is long again.
I think they will cut it short again next summer.
Well I have a lot of pictures from Flamingo Gardens this morning and I may set up a new
Blog thread this afternoon or tonight if I have time.
But I had once picture that after I cropped it it looked pretty good and I actually like it a lot.
I have already loaded it thru WU.
It is a picture of some of the flamingos in their pond.. and the way the reflections come off the water is sort of pretty.
I have it in WU photos and will put it in header of my next blog thread but here it is now.
Member Since: August 29, 2005 Posts: 315 Comments: 41227


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Association News
Douglas Oberhelman elected vice chair of NAM Board of Directors.
Press Release Summary:
October 12, 2010 - Douglas R. Oberhelman, CEO of Caterpillar Inc., has been elected to 2-year term as vice chair of NAM Board of Directors. Beginning his term on January 1 of 2011, Oberhelman looks forward to working with manufacturers nationwide as well as policymakers to advance initiatives to make U.S. best country for manufacturing in terms of meeting needs of American and worldwide markets. NAM President and CEO John Engler praised Oberhelman's leadership and experience as a "great asset."
National Association of Manufacturing - Washington, DC
Original Press Release
Douglas Oberhelman of Caterpillar Elected Vice Chair of the Manufacturers' Association
Press release date: October 7, 2010


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text:
CrooksandLiars.com just gets better every day and here is further proof.
Unless you've been living under a rock these past few weeks, you should know that the Pakistani
president dictator has declared martial law and assumed power, imprisoning opponents and so on, as these mad despots are bound to do from time to time in these tinpot democracies. So what's the big deal, you ask? Well, as stated previously, geopolitics is everything. Everything. From the demise of colonialism to the days of the N.A.M., Pakistan has always been America's preferred South Asian stooge, as a bulwark against Soviet-influenced India. From cheap F-16s to innumerable other preferred partner subsidies, Pakistan has always been America's darling in South Asia.
Then the wall fell, there was no giant Stalinistic bear behind the Iron Curtain and the States looked a little harder at its special relationship with its ally. When India beckoned with its 400 million strong consumerist demographic, eager to purchase everything the States could throw at it, from cheap irons to clothes to anything American, it suddenly got a lot tougher to justify these preferential treatments to Pakistan, a country with its own brand of fundamental Islam. But no one could ever accuse the Pakistanis of being dummies in a geopolitical war. Quick to capitalize on the "War on Terror", they promised to fight Afghanistan and the militants therein and thus remained in the good books of the Evil Empire.
So why is this embarassing? Well, for one, this goes against the military industrial complex is working very hard at to make you believe. The war in the Gulf is to spread democracy etc..etc….all that doesn't go down too well when one of your biggest allies himself seizes power in a markedly non-democratic fashion. But does the average North American even know where Pakistan is? Or care? Don't they have America's Next Top Model or some other bilge to watch, thereby programming themselves to be utter stooges to mediocrity and suburban despair. But that is a rant for another day. Anyway, the one good thing out of this situation so far is the delicious irony cake below.
In what has to be the biggest irony of the Bush administration, a regime known for its substantial faux pas' and gaffes, the White House tells Pervez Musharraf to "never restrict constitutional freedoms in the name of fighting terrorism." If this isn't laughable, I don't know what is.
Read the full story here:
[qt:../images/Dana-Perrino-Pakistan-11-05-07.mov 480 360]
She said that the administration is "deeply disappointed" by the measure, which suspends the country's constitution, and believes it is never "reasonable" to "restrict constitutional freedoms in the name of fighting terrorism":
Q: Is it ever reasonable to restrict constitutional freedoms in the name of fighting terrorism?
MS. PERINO: In our opinion, no.
For more analysis and so on, consult the media and draw your own conclusions once you've learned the facts. This video clip taken from here.


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Adventurous, genuine, caring, energetic, runner, skier, snowboarder, oil painting, creative, spontaneous, reading, career oriented, determined, traveler, gregarious, friendly, animal-lover, diverse and a thinker.
I'm originally from Vermont and have two wonderful parents that have been married 47 years. Their business afforded them the ability to take me traveling with them when I was very young. Much of my homework was done on the road. It wasn't uncommon for them to take me out of the school classroom several weeks at a time for the classroom of the world where I might be learning long division over looking the straights of Gibraltar at the cost of Africa or playing marbles in the dirt with kids at the Taj Mahal. I do remember it all as part of my childhood. I continued to travel into my adulthood but now vacation time from work is my biggest limitation! Needless to say I like adventure.
I enjoy cooking, reading a good spy novel ( lately anything by Vince Flynn). I have a BFA so I enjoy being creative with my hands from redesigning and rebuilding the basement of my house, landscaping, oil painting, photography, art museums and the live arts (I did improve when I lived in San Francisco).
I've worked for myself (owned a rafting and touring company on Oregon and was a ski/snowboard instructor), as well as working for small companies up to ( and the latest) very large global enterprises. Internet marketing and web design has always been a passion.
What makes me unique? Well aside from an amazing childhood and growing up in a family business (a country inn), I have a childlike energy and playful spirit. I look like I'm 39 but that belies the fact that I'm 49. I bring an energy, enthusiasm, spontaneous wit and passion not found in many others. If you're an explorer, FUN, like intelligent conversation, outgoing, love the outdoors, aspire to be a better person and can be silly then you're in the right spot.
My name is Charles but I have a much more creative nickname that my parents gave me. Just ask and I will reveal.
Winter sports
My creativity
Food & wine
Family & friends


text:
Minnesota Gas Prices Jump
Gas prices are on the rise again in Minnesota – especially in the southern half of the state. The statewide average is now $3.35 per gallon, which represents a 40-cent increase since early January. Triple-A …30 Jan 13
Local News, Multimedia, Sports - The Local Connection
Wheeler Dealer
Gas prices are on the rise again in Minnesota – especially in the southern half of the state. The statewide average is now $3.35 per gallon, which represents a 40-cent increase since early January. Triple-A …30 Jan 13
A Primary Election was held Tuesday for DFL candidates running for the open District 19A Minnesota House seat, and the winner was MSU Professor Clark Johnson with 66% of the vote. The longtime DFL activist …30 Jan 13
The Sibley County Economic Development Director has submitted his resignation to the Sibley County Board. County commissioners accepted the resignation of Tim Dolan "with regret" during the recent board meeting. Dolan's resignation is effective February …30 Jan 13
Minnesota's health insurance exchange has launched a new website to connect with more than 1-million Minnesotans who are expected to use the new marketplace to get coverage. The exchange is a key part of Minnesota's …30 Jan 13
New Ulm High School has selected the school's recipients for the annual Minnesota State High School League "Triple-A" Award. The recognition honors students who excel in Academics, Arts, and Athletics, and the New Ulm recipients …30 Jan 13
St. John Lutheran Home in Springfield has reached its goal of raising more than $95,000 for an upgrade at the nursing home. The capital campaign to raise the funds took only about 7 months. The …30 Jan 13
Two people were injured in a car crash on Highway 169 near St. Peter Monday morning. 51-year-old Victoria Hough of Mankato was driving a GMC Envoy northbound on the icy highway when she lost control …29 Jan 13
A New Ulm man has been sentenced to 90 days in jail and 2 years of probation for a gross misdemeanor obstructing the legal process charge. 56-year-old Mitchell Robert Hottman had been facing felony stalking …29 Jan 13
860 AM KNUJ/SAM 107.3 and your New Ulm Hy Vee announce this month's Hometown Hero: Jim Neid of St. James. In 2005, the St. James City Celebration was almost dropped. Jim organized a small group …


text:
Wednesday, January 22, 2014
St. Frances Animal Center of Georgetown has many animals seeking new homes. The Georgetown Times will feature Pets of the Week each Wednesday.
Hey yall, Im Marbles. The staff found me, my brother, sister, and mom in a box in front of the door. Since coming to Saint Frances Ive spent my time playing and taking long naps. I love people and cuddle time is my favorite time. Im ready to find my forever home. If you think were meant to be, please come visit me today.
Heres a little song I wrote, You might want to sing it note for note, Dont worry, be happy. This bundle of joy just cant help but bring smiles to all the faces he meets. With a story like Happys most people become overjoyed at the progress this little guy has overcome. From being a very shy boy who would hide in his crate, freeze when on the leash, and turn his head away when being stroked.
Now, Happy is truly a happy dog. He walks great on a leash, attends the dog park regularly where he does amazing with other dogs, and is both open and accepting of people. If you are interested in adopting Happy, please contact us at 843-546-0780.
Hello, my name is Allison, I am a Lab Retriever Mix. I arrived at Saint Frances in hopes of finding a family to call my own. I realized that life on the road just is not for me. I am energetic and friendly. I love toys, going for walks, and I love treats. I want to share my love with someone who will truly love me and enjoy the happy dog I am. Come visit me today at the center.
For more information, call 843-546-0780 ext. 222, or visit the center at 125 Ridge Road, Georgetown. Appointments are preferred
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Second Treaty Of Fort Laramie
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text:
World heritage
Language(s): English, French, Spanish, Arabic
More than 3,000 years ago, between the first and second cataracts on the West Bank and the Nile, the Egyptian Pharaoh commanded a colossal temple, and a smaller one along with it, to be carved out of the rock. For thousands of years, the sitting figure of Ramses II watched over the Nile, till the construction of the Aswan dam threatened to drown the ancient temple under the waters of the river. In an unparalleled feat of engineering, the rock temple was taken apart and re-erected on a site sixty metres higher and further away from the Nile.
on this subject: Abu Simbel in the World Heritage
Place/country: Egypt,
Series: World Heritage TV series/Serie TV Patrimoine mondial
Type: Documentary
Credits: TransTel, Germany (publisher), UNESCO Culture Sector (producer).
Published in: 1989
LICENSING: for inquiries about licensing or requests for CD/DVD copies of this material, please contact the publisher or the author directly. You may also wish to consult our FAQs 6 to 9


text: We've supplied over 100 million pounds worth of floors during our time, so we've picked up a thing or two from serving all those satisfied customers. In fact, our history goes back to 1985 and we were the first online retailer of flooring in the UK. All of the expertise we've picked up along the way goes straight into our products, our passion and ultimately, your floor. If you'd like to know a little more, then click below.Read more