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realmagick.com The shrine of knowledge.
- Agricultural Biotechnology in Indonesia Endang Sukara and I.H.
- Agricultural Biotechnology in Indonesia. Endang Sukara and I.H.
- www.bic.searca.org
- the last meal of the buddha - JStor
- agree on the meaning to give to sukara-maddava. One of them is the canonical Pali Commentary on the Dlgha Nikãya, Sumahga- lavi/ãsini, and the other, the ...
- www.jstor.org
- Mr Biljana Sukara- Ćelić
- Mr Biljana Sukara-Ćelić, rođena 1977. godine u Hamburgu, birana je 2008. godine u zvanje višeg asistenta na Odsjeku za matematiku Univerziteta u Banjoj.
- www.imvibl.org
- Tropical Forest Biodiversity to Provide Food, Health and Energy
- May 2, 2014 Endang Sukara,. Research Center for Biotechnology, Indonesian Institute of Sciences (LIPI), Cibinong Science Centre (CSC), Jl. Raya Bogor ...
- ac.els-cdn.com
- Meeting Summary Report (First Draft)
- Oct 10, 2012 Endang Sukara, Vice Chairman, Indonesian Institute of. Sciences, presented on " Indonesia's Science Funding Scheme and Review of.
- www.jsps.go.jp
- Sundeep Kishan's Upcoming Run Movie Audio Launch Today: Watch Here Live Streaming
- The movie is produced by Sudhakar Cherukuri under his banner Pixel Dreams. Anil Sukara is another producer for the movie. The trailer of the movie was released by the movie makers earlier and the trailer created enthusiasm for the audience to watch the ...
- Menunggu Revisi Undang-Undang
- Masalah pencurian sumber daya genetik, menurut Profesor Riset Bidang Mikrobiologi Lembaga Ilmu Pengetahuan Indonesia (LIPI) Endang Sukara, bisa diselesaikan jika ada kelembagaan yang kuat. Kerjasama antara Badan Koordinasi Penanaman Modal ...
- Memphis City Council Runs Smart Meter Gauntlet
- Sukara Yahweh touched on that topic too as he warned the smart meters are another indication the U.S. is joining the "North American union.
- Christopher Aguinaga promotion to Loy Norrix dean among KPS personnel changes
- KALAMAZOO, MI -- Christopher Aguinaga has been promoted from assistant principal to dean of students at Loy Norrix High School, an appointment approved Thursday by the Kalamazoo Public Schools Board of Education. Aguinaga's appointment was ...
- Shahbaz vows justice in self-immolation incidents
- MPA Hamad Nawaz Khan Tipu, DCO Hafiz Shaukat Ali, IG Punjab Mushtaq Sukara, DPO Awais Ahmed Malik, AC Dr Saifullah Bhatti, Mad Shahda Naeem Dasti, President City Press Club Dr Khalid Mehmood Zaffar Chaudhry, SP (Investigations) Rao Arif ...
- Leila of Cairo - Sukara - Amazon.com Music
- Sukara is the second great volume of Egypian Bellydance music by Leila of Egypt. This CD features classic songs by Om Kalthoum, Abdle Halim Hafez, Warda ...
- www.amazon.com
- Leila of Cairo - Sukara - YouTube
- Apr 4, 2014 Sukara is the second great volume of Egypian Bellydance music by Leila of Egypt. This CD features classic songs by Om Kalthoum, Abdle ...
- www.youtube.com
- Marius Tepeliga - Nebuna mea sukara mea ( Oficial Video Live
- Aug 26, 2015 Pentru contactarea solistului sunati la 0786104698 Abonați-vă la canalul nostru pentru ultimele noutăți Subscribe to Klu Music Video ...
- www.youtube.com
- Iris Sukara - Drum Solo - Aini ya Aini 2014 - YouTube
- Feb 15, 2014 :D Iris Sukara performing in Rosadela's International Festival Aini ya Aini 2014, which takes place every January in Valencia...
- www.youtube.com
- Iris Ferrer | Facebook
- Iris Ferrer (Iris Sukara). Iris Ferrer's Profile Photo. Iris Ferrer (Iris Sukara) is on Facebook.
- www.facebook.com
Sukara is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Sukara books and related discussion.
Suggested Pdf Resources
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Suggested Web Resources
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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Have dinner with chef Edward Lee at Bacchus on May 21
Edward Lee might be best known nationally for his turn on Bravo's "Top Chef," but he has gained renown since then for his restaurant, 610 Magnolia, in Louisville (he was a James Beard Award finalist this year). A new cookbook, "Smoke & Pickles," is putting him in the spotlight again, and he'll be at Bacchus on May 21 for a four-course dinner of dishes from the book. »Read Full Blog Post
AT&T drops Al Jazeera America news channel just before debut
Al Jazeera America, the first all news cable network since Fox News Channel debuted in 1996, begins broadcasting at 2 p.m. Tuesday. But shortly before its debut AT&T U-verse announced it would not carry the channel in a contract dispute, according to The Wrap.
It is also not carried by Time Warner Cable. It will be carried by DirecTV (Channel 358) and DISH (Channel 215). It will be in less half as many TV homes as CNN and Fox. »Read Full Blog Post(104)
New Berlin grad makes Betty White leap for joy on 'Tonight Show' segment
New Berlin — New Berlin West High School graduate Kevin Bania appeared on the Aug. 8 "Tonight Show with Jay Leno" in a segment called "Does This Delight Betty White?" »Read Full Article
Milwaukee Film Festival announces music movie program
Film and music are twin siblings from another mother. Because they are so alike in creative spirit, it's not surprising when filmmakers explore the musical impulse, and vice versa.
This is particularly evident from the 2013 Milwaukee Film Festival's eight-film Sound Vision lineup, announced Tuesday. »Read Full Blog Post(1)
On Tap Today: Wanted - Seeking Milwaukee teen pop fans to 'Call Me Maybe'
Carly Rae Jepsen, pictured here opening for Justin Bieber at the BMO Harris Bradley Center last October, will co-headline the Riverside Theater tonight with boy band the Wanted. Journal Sentinel photo by Mike De Sisti. »Read Full Blog Post

subset: commoncrawl


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Ashvin Gidwani with Vivek Jain during 'AGP Multimillion Race '13', held at Turf Club in Mumbai, on February 17, 2013. (Pic: Viral Bhayani)
See more of: Vivek Jain, mumbai celebs events, ashivin gidwani
Aman Verma with Ashvin Gidwani spotted at the special screening of the play 'Blame It On Yashraj', held at St. Andrews auditorium in Mumbai.
See more of: Aman Verma, play 'blame it on yashraj', ashivin gidwani
Interest Networkitimes


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42 CFR 422.1 - Basis and scope.
(a) Basis. This part is based on the indicated provisions of the following:
(1) The following provisions of the Act:
(i) 1128J(d) - Reporting and Returning of Overpayments.
(ii) 1851 - Eligibility, election, and enrollment.
(iii) 1852 - Benefits and beneficiary protections.
(iv) 1853 - Payments to Medicare Advantage (MA) organizations.
(v) 1854 - Premiums.
(vi) 1855 - Organization, licensure, and solvency of MA organizations.
(vii) 1856 - Standards.
(viii) 1857 - Contract requirements.
(ix) 1858 - Special rules for MA Regional Plans.
(x) 1859 - Definitions; enrollment restriction for certain MA plans.
(2) 8 U.S.C. 1611 - Aliens who are not qualified aliens ineligible for Federal public benefits.
(b) Scope. This part establishes standards and sets forth the requirements, limitations, and procedures for Medicare services furnished, or paid for, by Medicare Advantage organizations through Medicare Advantage plans.


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By Simon Rocker
June 14, 2013
Kabbalah was once dismissed as medieval mumbo-jumbo that no self-respecting Jew in the West would give any time to.
Now the mystical tradition is widely recognised as the extraordinary product of the Jewish religious imagination and an enduring source of spiritual insight.
That is no small measure due to Gershom Scholem, the German-born Israeli scholar (1897-1982), who gave academic respectability to the study of Kabbalah.
On Monday to Wednesday next week, the Institute of Jewish Studies in London is devoting its summer conference to Scholem's work.
Papers will be given by leading scholars from around the world.
The conference is free. For more details, see here.


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Cathy by Cathy Guisewite
- February 23, 2013
- From Beginning
- Previous feature
- Next feature
- Current
Comments (5) (Please sign in to comment)
Sadly, not always mom :-(
Maybe, Cathy's mom, but most daughters aren't like Cathy!!
Good morning Cathy nuts!! For the first time in a long time, I don't have anywhere that I HAVE to go today. What am I going to do with my time?? ;-)
Have a great day, friends!
"I have no grounds to reject him until I get to know him". Coming from someone else those would be words of wisdom.
Cathy . . . one meeting, one time, in a coffee shop and already she's breaking up with an imaginary boyfriend! What a nut-job!!!!!
Hi, rgcviper!
Susan: Good eye on the lack of Mom wearing an apron to bed! But given she wears it outside the house — even to go shopping at the mall — I wouldn't have been the least bit surprised to find her wearing it to bed at night too. Why, you simply never know when you might accidentally sleepwalk down to the kitchen and just start baking a cake in the middle of the night. Should that ever happen she'd be like a Boy Scout: always prepared!
lightenup: Hope you're having a good day today! In answer to your question . . . the oh-so-addictive Pinterest, perhaps?!? That's where I'm headed shortly!!!!! ;-)
Hello and Happy Saturday, fellow "Cathy" fanatics! Hope you're all having a really wonderful weekend so far! Thanks for all the congrats regarding my positive dental appointment this past Thursday. The happy news that I can most likely put off any new root canal work (at least, for a little while longer, anyhow) was most definitely a huge weight off my mind!!!!! Oh, happy, happy day!!!!!
Ow—I think my head just exploded.
HI, MOM. Hope you're having a nice weekend, Clan.
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Dr. Anitha Vyza specializes in geriatric medicine, family practice, internal medicine in Frisco, Texas.
Dr. Anitha Vyza has been compared 112 times. Details of Dr. Vyza's 23 years experience as an MD, her 3 hospital affiliations and education at NTR University of Health Sciences, Vijayawada are available on your free doctor report.
Primary Location for Dr. Vyza
Patient Ratings and Reviews
Dr. Anitha Vyza has an average rating of 3.5 stars (out of 5) with a rating of Good based on 11 reviews.
Have you visited Dr. Anitha Vyza? Rate you experience below.
Board Certification, Specialty and Expertise
Dr. Anitha Vyza has been identified as specializing in Geriatric Medicine, Family Practice and Internal Medicine.
She obtained board certification from The American Board of Internal Medicine for Internal Medicine.
Accepted Insurance
Insurance plans and networks accepted by a doctor are not necessarily universal across all locations at which the doctor practices. This can be affected by many factors such as different group practices, hospital affiliations and working arrangements at those locations. Checking that the doctor you are visiting and the facility they are at are in-network providers for your insurance plan can save you money and headaches later from surprise medical bills.
Dr. Anitha Vyza accepts the following plans at 4525 Ohio Dr, Frisco, TX
- Aetna
- United Healthcare - Direct
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Hospital Affiliation
A hospital affiliation covers any doctor who has an affiliation, association or admitting privilege with a hospital. A doctor's particular affiliation to a specific hospital can translate to the overall quality of that provider.
Dr. Vyza is affiliated with 3 hospitals:
3901 W 15th St
Plano, Texas
Dr. Vyza attended medical school at NTR University of Health Sciences, Vijayawada Andhra Medical College and graduated in 1993 having 23 years experience.
While there is no proven correlation between the quality of one's educational institution and the quality of one's professional competence, it is often an indicator. Medical schools have various levels of selectivity (some are harder to get into than others), and both the quality of their clinical training and level of research are measured. Additional medical training in both residency and fellowships and the facilities they are conducted at also provide a history of the doctors' level of training and experience.
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3900 W 15th St, Plano, TX 75075
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- Years Experience
17 Years Experience
Hospital Affiliation
Medical Center of Plano
Plano, Texas
University of Texas Medical School at Houston
- Compared: 434
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4525 Ohio Dr, Frisco, TX 75035
General Info
- Years Experience
23 Years Experience
Hospital Affiliation
Centennial Medical Center
Frisco, Texas
University of Texas
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- Compared: 235
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4525 Ohio Dr, Frisco, TX 75035
General Info
- Years Experience
20 Years Experience
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Medical Center of Plano
Plano, Texas
Rajiv Gandhi University of Health Sciences
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Range Rover
Land Rover
A unique proposition, the Range Rover is a worthy alternative to conventional luxury saloons – and has a wider gamut of abilities than all of them. …
The E-Class makes more of a case for itself than any other mainstream Merc. It's elegant, classy, well equipped and good to drive.
The Mercedes E-Class is the German car maker's answer to the Audi A6, BMW 5 Series andJaguar XF. It's what we class as a large executive saloon, which means it's longer than compact executives such as the Audi A4, BMW 3 Series and Mercedes' own C-Class.
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The new saloon range has actually been rationalised, and there are now only two engines available, both of them are diesels: there's an entry-level 2.0-litre (badged E 220 d) and a 3.0-litre V6 diesel.
So can this latest E-Class build on the qualities of its illustrious predecessors, and does it still stack up against its rivals in this ultra-competitive class? Read on over the next few pages to get our in-depth impressions on the E-Class, along with our final recommendations for trim levels and engines.
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Audi A4
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The Superb is comfortable, well equipped, great value for money and one of the roomiest cars in its class. …


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Results 1 to 2 of 2
- 04-15-2014, 08:09 PM Thread Author #1
- Posts
- 492 Posts
- Global Posts
- 499 Global Posts
I am thinking of switching from POP to IMAP for my 2 email accounts on my S3 and have a couple of quick questions for you.
1) I cannot find the place where I set the maximum number of emails (or length of time, don�t remember which is use) so please guide me to the setup.
2) With IMAP is every folder sync�d or can I specify only some?
3) Is there any reason you would suggest that I do NOT switch to IMAP?
Thanks for your help!
- Posts
- 420 Posts
- Global Posts
- 423 Global Posts
Re: MailDroid
1. IMAP is very different than POP3, you don't really need to set this
2. You can specify
3. No, if you have IMAP, unless there is a good reason to use POP, I always suggest IMAP.
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IAAT Test Preparation
Is your child going to take the Iowa Algebra Aptitude Test (IAAT™)? If so, here's what you need to know so that your child will be ready on test day.
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Designed for administration to students in grades 7 or 8, the IAAT assesses knowledge of basic algebraic concepts. It also integrates other math principles such as geometry and statistics. The purpose of the test is to assess how well a student understands these concepts, which are considered key for moving through grade levels.
IAAT™ Content
The IAAT test is administered in a group setting by school administrators/teachers. It contains 60 questions divided into four parts:
Part 1: Pre-Algebraic Number Skills and Concepts: Measures how well students understand the mathematical skills and concepts necessary for success in an algebra course.
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Preparing for the IAAT is important because it is (usually) a one-shot deal. A poor score could affect your child's later education, particularly if they are considering a STEM career or a magnet or specialized high school. Our Practice Test for the IAAT offers practice questions to familiarize your child with the test's mathematical concepts and testing format as well as help eliminate test-taking anxiety.
The Iowa Algebra Aptitude Test™/IAAT is a registered trademark of Riverside Publishing, a Houghton Mifflin Company, or their affiliate(s), or their licensors. Test Tutor Publishing is not affiliated with or related to Houghton Mifflin or its affiliates. Houghton Mifflin does not sponsor or endorse Test Tutor Publishing products or services. Test Tutor Publishing's products and services have not been reviewed, certified or approved by Houghton Mifflin. Trademarks referring to specific test providers are used by Test Tutor Publishing for nominative purposes only and such trademarks are solely the property of their respective owners.


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Dr. Alex Perez specializes in pain management, psychiatry in East Stroudsburg, Pennsylvania.
Dr. Alex Perez has been compared 777 times. Details of Dr. Perez's 17 years experience as an MD, his hospital affiliation and education at Ponce School of Medicine are available on your free doctor report.
Primary Location for Dr. Perez
175 E Brown St
Suite 103
East Stroudsburg, PA 18301
Patient Ratings and Reviews
Dr. Alex Perez has an average rating of 3 stars (out of 5) with a rating of Good based on 26 reviews.
Have you visited Dr. Alex Perez? Rate you experience below.
Board Certification, Specialty and Expertise
Dr. Alex Perez has been identified as specializing in Pain Management and Psychiatry.
Accepted Insurance
Insurance plans and networks accepted by a doctor are not necessarily universal across all locations at which the doctor practices. This can be affected by many factors such as different group practices, hospital affiliations and working arrangements at those locations. Checking that the doctor you are visiting and the facility they are at are in-network providers for your insurance plan can save you money and headaches later from surprise medical bills.
Dr. Alex Perez accepts the following plans at 175 E Brown St, East Stroudsburg, PA
- Horizon BCBS
- Highmark BCBS
- Great West
- Coventry Health Care
- Aetna
Hospital Affiliation
A hospital affiliation covers any doctor who has an affiliation, association or admitting privilege with a hospital. A doctor's particular affiliation to a specific hospital can translate to the overall quality of that provider.
Dr. Perez is affiliated with 1 hospital:
206 E Brown St
East Stroudsburg, Pennsylvania
Dr. Perez attended medical school at Ponce School of Medicine and graduated in 1999 having 17 years experience.
While there is no proven correlation between the quality of one's educational institution and the quality of one's professional competence, it is often an indicator. Medical schools have various levels of selectivity (some are harder to get into than others), and both the quality of their clinical training and level of research are measured. Additional medical training in both residency and fellowships and the facilities they are conducted at also provide a history of the doctors' level of training and experience.
Patients may also know Dr. Alex Perez MD as:
Trending Providers
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200 Eaglesmere Cir, East Stroudsburg, PA 18301
General Info
- Years Experience
35 Years Experience
Hospital Affiliation
Pocono Medical Center
East Stroudsburg, Pennsylvania
Columbia University
- Compared: 278
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Star Player Live
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Great Features
✓ Mobile ready LIVE Team Gamecast enables fans, parents, coaches, to follow the game, review scores and stats using any smartphone or web browser
✓ Automatic scoring Alerts via email or text message (messages credits are purchased in blocks via In-App Purchase)
✓ Centralized cloud-based website where you data is stored. You can have Star Player Live on an iPhone and iPad, using the same account with the same data.
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✓ 3 free 'score game' credits to get you started right away.
Star Player Live for parents solves the problem of "can't be there". Now you get the next best thing, score, stats, and play-by-play.
Star Player Live for coaches gives you game changing stats, in real-time. Take a quick look at the end of the period, or quarter, for an edge.
Star Player Live for leagues enables a deep look into the player pool. Find those stand-out players. Using Star Player Live, there are no maintenance fees, no website setup costs, no contracts and it is compatible with your existing league management system.
Star Player Live for recruiters allows you to send a scout to a game, task them to follow a player and capture stats to the depth of your interest. Our service is better, and much less expensive than other products.
Remember that you can cccess your Star Player Live account on the web (www.starplayerlive.com). It's free and is being updated every day. Use your same login and password on the website and the app.
What's New in Version 2.2
Performance and usability enhancements:
* quicker stat entry with background uploading
* improved offline use
* numerous subtle ui improvements
* bug fixes
* this new version requires iOS 5.0 or greater
Customer Reviews
new Season New Stats - Great App
Excellent app! I use it for tracking youth hockey, this my second year. The Grandparents especially like it because they're not able to travel and can view the GameCast & Statistics while it's happening. Also use the email and text alerts to provide summary information at the end of each period and game final so parents who can't travel can still find out what's happening with the game, ironically, some even complain when they don't revive game or individual player updates :-)
It's very in-expensive for what it does like keeping the family updated, tracking goalie stats so my son can see what his SA % is. Pay attention to how many text alerts you have as you can burn through them quickly. Usually I send period / game updates via email and player updates via text msgs, balances out.
If you have suggestions, drop them in via the support email address, I have and the creator is very receptive to productive ideas as he's always looking to improve the products usability.
I wanted to like it, but...
Theres no rock solid lacrosse stat tracking app, so I was hopeful this would be a winner. Unfortunately, they leave out some critical stats such as Opponent Ground Balls. That's a hugely important stat in the game of lacrosse: total ground balls for each team. Another missing: Shots On Goal, ManUp Success/Failure, Clear Success/Failure, Ride Success/Failure, Goal In Transition.
Also need to look at ways to eliminate as many "taps" ax possible. Sometimes it's very difficult to keep up w/ the game because you're having to tap the screen too many times for a single stat.
Great App!
I used this app the final 8 games of my sons hockey season. It is fantastic! It is easy to score and the real time posting is incredible. I had parents and grandparents following the action in real time, even if they weren't there. add the ability to see each play, game stats, and season stats, who wouldn't use this. Am going to use for the entire season next year
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- © Copyright 2009-2011 by One Moxie Ventures LLC
Compatibility: Requires iOS 5.0 or later. Compatible with iPhone, iPad, and iPod touch.
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PTCS, I suggest you add a new tip: Don't sign up on any sites in the InfinityBux network (that was a joke)
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Click the link below to see PowerfulBux:
Really good tips & hints, especially for those who are just beginning to learn about the PTC sites.
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Meeting day and location has changed!
We now meet FRIDAYS at 6:00 in the Formula SAE shop, TFRB L10 (MAP)
Officer Hours
Each year the Formula SAE team builds an open wheeled, open cockpit, formula style race car. The team is responsible for every aspect of the car, from design to construction to testing. The car is designed according to rules provided by the Society of Automotive Engineers for an annual competition against universities from around the world.
There is more to the competition than just the cars
speed. The
car is judged on its performance in many different trials, including endurance,
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cars performance the team is also judged on their engineering design,
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Anyone who is interested can join, regardless of major. We are always looking for people to help out with design, fabrication, fund raising, etc. No experience? No problem, we can teach you everything that you need to know. Contact us for more information.
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on Jun 15, 2013
at 9:41 PM
I'm one of Cheezburger's resident time lords. I can regenerate when I accidentally get killed. Accidentally burned myself to death with hot oil attempting to make donuts for the very first time, and now I have regenerated into a hobbit.
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Wheel locks...
So it would seem that I didn't get the wheel lock key for three of the wheels. Any ideas what I can do?
If you have the appropriate tools (impact driver and accessories) you should still be able to get them off.
Otherwise just take it to any of those tire & lube shops and they will usually take them off for like $5 a wheel in a matter of minutes... be sure to bring new lugs to replace the lock ones (these can be purchased at any auto parts shop).
So buy new lugs then go to discount tire and have them do it?
You need a different key for each wheel?
Don't believe so. But I don't have a key at all is the problem.
After I got mine off, I threw them in the trash. I spent more time trying to line up the key, than it was worth.
Air chisel if you have one or can get your hands on one. I stripped the hell out of a lug once and hit it with an air chisel real quick and it split so I could pull it off
Get a socket slightly smaller than the lug and hammer it on. You should be able to get a decent bite on it then.
Use an impact socket if you try this. Standard sockets split way too ease ;)
Ed, you of all people should know that I don't have a clue what that is.
Hopefully I'll have the cash to buy what I need for the steering. Then I'm gonna need to buy you breakfast again. :)
Just concentrate on getting a new steering box for now. I will be replacing my steering linkage fairly soon.
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Patent application title: Use of Polymeric Resins for the Adsorptive Extracorporeal Removal of Inflammatory Mediators in the Treatment of Systemic Inflammation-Related Diseases
Mauro Atti (Bologna, IT)
Mary Lou (Medolla, IT)
BELLCO S.r.l.
IPC8 Class: AB01D6124FI
USPC Class:
Class name: Processes liquid/liquid solvent or colloidal extraction or diffusing or passing through septum selective as to material of a component of liquid; such diffusing or passing being effected by other than only an ion exchange or sorption process including ion exchange or other chemical reaction
Publication date: 2010-02-25
Patent application number: 20100044312
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It is described a kit for treating a systemic inflammatatory related
disease comprising a) a high permeability filter having a pore size
designed to let inflammatory mediators to pass and b) means to retain
said mediators but not serum albumin.
1. Kit for purifying blood comprising a) a high permeability filter having
a pore size designed to let inflammatory mediators to pass and b) means
to retain said mediators; characterized in that said high permeability
filter is selected such that to allow passage of high molecular weight
inflammatory mediators as well as serum albumin; and in that, in
combination, said means to retain said mediators are selected so as to be
able to retain by subsequent adsorption said high molecular weight
inflammatory mediator but not serum albumin, so as said kit is able to
effectively treat a systemic inflammatory related disease.
2. Kit according to claim 1, characterized in that said pore size is selected in a range such that to give rise to a sieving coefficient of the filter of less than 0.4 for IgM and of more than 0.6 for albumin.
3. Kit according to claim 1, characterized in that said means to retain said mediators comprise at least one cartridge comprising a sorbent material selected from the group consisting of an hydrophobic polystyrene resin, an ion-exchange polystyrene resin, a bonded silica resin or mixtures thereof.
4. Kit according to claim 3, characterized in that said hydrophobic polystyrene resin is selected from the group consisting of the styrene-methylacrylate resins and copolymer divinylbenzene-polystyrene resins.
5. Kit according to claim 3, characterized in that said bonded silica resin is selected from the group consisting of silica resins with bonded phase functional groups.
6. Kit according to claim 3, characterized in that said sorbent material has a granules size comprised between 35 and 200 micron.
7. Kit according to claim 3, characterized in that said adsorbent material has a pore size comprised between 50 and 3000 Å.
8. Kit according to claim 3, characterized in that said cartridge comprises a polystyrene/divinylbenzene resin having a pore size of 300 Å and a granule size of from 35 to 120 micron.
9. Kit according to claim 8, characterized in that said cartridge comprises a polystyrene/divinylbenzene resin having a granule size of 75-120 micron.
10. Kit according to claim 1, characterized in that said means to retain inflammatory mediators comprise more than one cartridge, each cartridge comprising a different adsorbent material designed to retain one or more different inflammatory mediators, the inflammatory mediators retained by each cartridge being different from one another.
11. Kit according to claim 1, characterized in that said means to retain said mediators are selected so as to be able to retain by subsequent adsorption inflammatory mediators selected from the group consisting of VEGF, Kallikrein, myoglobin, C-reactive protein, cytokines, and chemokines.
12. A method of treating a patient affected by a systemic inflammation related disease by selective absorptive removal of at least one inflammatory mediators selected from the group consisting of VEGF, Kallikrein, myoglobin, C-reactive protein, cytokines, and chemokines, in particular IL1, IL6, IL8, IL12, IL18, Tumor necrosis factor, macrophage inflammatory protein-1, monocyte chemotactic protein, but not of serum albumin, contained in a ultrafiltrate or plasmafiltrate derived from the blood of said patient using a sorbent material selected from the group consisting of an hydrophobic polystyrene resin, an ion-exchange polystyrene resin, a bonded silica resin, or mixtures thereof.
13. (canceled)
14. (canceled)
15. The method according to claim 12, characterized in that said systemic inflammation related disease is selected from the group consisting in: respiratory distress syndrome, acute lung injury, acute respiratory failure, severe pancreatitis, tumor lysis syndrome, myeloma, myasthenia gravis, vasculitis, rhabdomyolysis, systemic inflammatory response from coronary artery bypass grafting during cardiopulmonary bypass, systemic sclerosis, end stage renal diseases, age related macular degeneration, diabetic nephropathy.
16. Kit according to claim 1 characterized in that said means to retain said mediators are selected so as to be able to retain by subsequent absorption inflammatory mediators selected from the group consisting of IL1, IL6, IL8, IL 12, IL 18, Tumor necrosis factor, macrophage inflammatory protein-1, and monocyte chemotactic protein.
[0001]The present invention relates to a highly effective use of filters and sorbents for purifying blood in patients affected with systemic inflammatory related diseases.
[0002]Inflammation occurs as both a physiological and pathophysiological response to stress, such as injury, infection or a related specific disease, and results in local and general responses by the body. The local response is important for healing and as a defense against infection. This occurs via local production of specific and non-specific inflammatory mediators, such as angiopoietins, and cytokines. These are often involved in the systemic inflammatory response and the Systemic Inflammatory Response Syndrome (SIRS).
[0003]The general response takes place in the form of endocrinal, metabolic and biochemical reactions, with the extent of the response depending on the severity, intensity and duration of the stimulus. The general response is controlled by signals between the hypothalamic pituitary axis, the neuro-endocrinal hormone system and the autonomic nervous system. This coordinated action is referred to as the "stress response." The net effect of the stress response includes an increase in cardiac output, heart rate and blood pressure, peripheral and splanchnic vasoconstriction and coronary and cerebral vasodilation, increases in respiratory rate, sodium and water retention, increased coagulation, metabolic changes with hyperglycemia, and reduced urinary output.
[0004]While the stress response can be beneficial in aiding the recovery of the host, it is also a common link in many diverse critical illnesses. For instance, patients suffering from acute respiratory distress syndrome, acute lung injury, or acute respiratory failure who are on mechanical ventilation can experience trauma induced by the mechanical stretching of alveoli from the ventilator. The trauma can induce the subsequent release of inflammatory mediators, particularly vascular epithelial growth factor (VEGF), causing increased endothelial permeability, edema and increasing systemic inflammation and eventual organ dysfunction/failure. Patients with end stage renal diseases and diabetes also experience chronic inflammation and increased incidences of co-morbidities associated with it, such as cardiovascular disease. Vasculitis, a disease involving inflammation in blood vessels, can lead to damage of the body's organs, and even an aneurysm rupture. Patients suffering from sepsis and pancreatitis can also experience local and systemic inflammation over the course of the disease progression.
[0005]VEGF plays a role in a multitude of pathologies, including solid tumors and hematologic malignancies, intraocular neovascular syndromes, inflammation and brain edema, and pathology of the female reproductive tract (Ferrara et al., Nature Medicine, Vol. 9, No. 6, June 2003: 673-674). Current treatments to decrease VEGF are ranibizumab (Lucentis®, GenentechNovartis) pegaptanib (Macugen® Pfizer/Eyetech) and Verteporfin PDT (Visudyne, Novartis) for age-related macular degeneration and bevacizubab (Genentech) for advanced colorectal cancer.
[0006]In patients suffering from the above-mentioned ailments, the blood gradually retains increasing quantities of toxins and inflammatory mediators. In healthy subjects, inflammatory mediators, cytokines or toxins are normally produced "as needed" and eliminated from the bloodstream. However, when the level of locally produced toxins rises uncontrollably, they can spill over into the plasma circulation causing profound endothelial dysfunction and the activation of many different types of inflammatory cells. This systemic inflammation and endothelial dysfunction can potentially lead to vascular permeability, organ hypoperfusion and eventual gut translocation of bacterial products such as endotoxin, which can further amplify the inflammatory response.
[0007]The process leading to multiorgan dysfunction is very complex and involves many overlapping pathways, including those of inflammation, coagulation as well as metabolic pathways. Pharmaceutical inactivation or immunomodulation of inflammatory mediators and cytokines is a generally known method for reducing blood toxins. However, it has been largely unsuccessful because inflammation involves redundant pathways. Additionally, inactivation of single mediators is often ineffective as other simultaneously produced mediators can still amplify the inflammatory response. Moreover, many mediators are produced after stimulating important pathways (such as NFkB).
[0008]Inactivation of such pathways can be detrimental if the same pathway also produces beneficial molecules. Finally, the detrimental effects of inflammatory mediators is often time dependent. Inactivation or removal of inflammatory mediators may be of benefit during mediator spill-over, but may be detrimental if the mediator plays a role in cell regeneration or healing. Unfortunately, many pharmaceuticals cannot be easily reversed or regulated.
[0009]Other commonly used methods of blood purification include absorbing the toxins on solid media (hemo- and plasmaperfusion), or by ultrafiltering the blood or plasma through appropriate semipermeable membranes, either by convection with the aid of a pressure gradient (TMP) through the membrane (hemo- or plasmafiltration), or by diffusion by bringing the blood or plasma to be purified into contact with one side of the membrane, and an appropriately formulated wash solution into contact with the opposite side (hemodialysis).
[0010]All of the above systems, however, present drawbacks. Hemoperfusion consists of percolating blood directly through a filter of adsorbent material, which must therefore be made highly biocompatible. This is usually achieved by covering the adsorbent particles with appropriate material which, however, seriously impairs the toxin-retaining capacity of the particles. In the case of plasma-perfusion, the blood is first filtered to separate the plasma, which is then percolated through the adsorbent material. Though this to some extent solves the problem of biocompatibility during the perfusion, the increase in the viscosity of the blood during filtration may result in extensive clotting through the membrane, so that in any case the blood must be treated with anticoagulants (heparin).
[0011]Hemo and plasmafiltration, on the other hand, only provide for removing high molecular weight toxins, and produce a considerable weight loss which must be compensated for by feeding an infusion solution into the patient's blood. According to EP 0958839B1, the above problem may be partly solved by regenerating the ultrafiltrate, by adsorbing the medium-high molecular weight toxins in it by percolating it through uncoated-activated-carbon-based hemoperfusion cartridges such as DETOXIL2® (SORIN BIOMEDICA, Italy), so that the regenerated ultrafiltrate may be used, as it is or with additions, as an infusion solution.
[0012]Hemodialysis, particularly if combined with one or more of the above methods, is very effective in removing small water soluble toxins, but by itself, is largely ineffective for removing larger inflammatory mediators or toxins since these are not removed efficiently by diffusion. In particular, cytokine removal is fairly poor, so that, at present, organic malfunctions caused by acute organ failure can be no more than delayed as opposed to fully prevented.
[0013]This has been dealt with by EP0958839B1 at least in relation to a particular morbidity situation consisting in acute organ failure.
[0014]It is the aim of the present invention to provide an alternative means of treatment of systemic inflammation and of at least a number of its related diseases, which is more effective than the known solutions and allows different kind of toxins, especially low and middle molecular weight toxins, to be eliminated from the blood in a relatively short intervention time and that can be easily regulated in order to adapt it to individual patient conditions.
[0015]The present invention accordingly relates to a kit for treating a systemic inflammation related disease according to claim 1.
[0016]According to a second aspect of the invention it is also provided the use of such kit according to claim 12.
[0017]The goal of extracorporeal adsorption according to the present invention is to use a high permeable filter that allow passage of high molecular weight inflammatory mediators (not usually removed by conventional hemodialysis or hemofiltration filters which have smaller pore sizes), such as vascular endothelial growth factor (VEGF) and angiopoietins, as well serum albumin. The high permeable filter is thus associated to means for the retention of such inflammatory mediators by subsequent adsorption using an adsorbent cartridge with a high affinity for them. Differently from previously known methods, the means to retain the inflammatory mediators are selected in order not to retain serum albumin, which can be accordingly reinfused in the patient avoiding loss of one of the most important physiologic proteins necessary to maintain oncotic pressure, its antioxidant capacity and its function as a trasport protein for fatty acids, bilirubin, trypotphan, calcium, steroid hormones an many other physiologic compounds.
[0018]A further advantages of the use of a high permeability filter is the possibility to increase the blood flow to be purified compared to the normal plasma filters known in the art.
[0019]Preferably the high permeability filter has a pore size that ranges between 0.4 and 0.6 micron and anyway are such that to give rise to a sieving coefficient for the filter of less than 0.4 for IgM and of more than 0.6 for albumin.
[0020]The means to retain inflammatory mediators comprise at least one cartridge comprising a adsorbent material selected from the group consisting of a hydrophobic polystyrene resin, an ion-exchange polystyrene resin, a ultrapure bonded silica resin or mixtures thereof. Preferably, the hydrophobic polystyrene resins are chosen from the styrene-methylacrylate and copolymer divinylbenzene-polystyrene group of resins, of which the AMBERCHROM® series of resin (Rohm Haas) is an example. The ultrapure silica resins are preferably chosen from silica resins with bonded phase functional groups of which TSK Gel reverse phase resin (Tosoh Bioscience), such as ToyaPearl Phenyl-650 is an example. The ion-exchange resin is selected from the group consisting of DEAE Sepharose (Tosoh Bioscience) or Amberlite® series of resin (Rohm Haas).
[0021]According to an embodiment of the invention the adsorbent material has a granules size comprised between 35 and 200 micron, and a pore size comprised between 50 and 3000 Å. Preferably, the cartridge comprises a polystyrene/divinylbenzene resin having a pore size of 300 Å and a granule size from 35 to 120 micron (for instance Rohm & Haas resin CG300® grade S, M and C respectively). The most preferred one is resin CG300M having a mean diameter of the granules of from 75 to 120 micron.
[0022]In a preferred embodiment of the invention, the means to retain inflammatory mediators comprise more than one cartridge, each cartridge comprising a different adsorbent material designed to retain one or more different inflammation mediator(s), the inflammatory mediators retained by each cartridge being different from one another.
[0023]The inflammatory mediators which can be removed with the kit of the invention are selected in the group of VEGF, kallikrein, myoglobin, C-reactive protein, cytokines and chemokines (particularly IL1, IL6, IL8, IL12, IL18, Tumor necrosis factor, macrophage inflammatory protein-1, monocyte chemotactic protein).
[0024]The inventors surprisingly found that the association of a high permeable filter and of resins as those disclosed in EP 0958839B1, allows to retain inflammatory mediators other than cytokines, i.e. low-middle molecular weight mediators, without significant loss in serum albumin which can be thus reinfused in the patient. Moreover, as an additional consequence of this surprising discovery, the association of the above disclosed absorptive resins and high permeability filter allows them to be used to treat a fair large number of diseases not directly related to acute organ failure.
[0025]Preferably, the inflammatory mediators retained (and so removed from the patient's blood stream) according to the present invention are associated generally to any systemic inflammation condition and more specifically to respiratory distress syndrome, acute lung injury, acute respiratory failure, severe pancreatitis, tumor lysis syndrome, myeloma, myasthenia gravis, vasculitis, rhabdomyolysis, systemic inflammatory response from coronary artery bypass grafting during cardiopulmonary bypass, systemic sclerosis, end stage renal diseases, age related macular degeneration, diabetic nephropathy.
[0026]Unlike more traditional methods of treating the above-mentioned illnesses, which include physical ingestion/exposure to drugs or irradiation which in essence are toxic to living systems, extracorporeal filtration has the advantage of the removal of toxins from the blood of the patient with minimal invasiveness. Additionally, removal can be done more quickly and for a specified time (duration) to remove mediators and then stopped when it is no longer necessary. This is advantageous over pharmacologic inhibition which often is not reversible and may require a longer duration of treatment.
[0027]Of added benefit is the adaptability of extracorporeal adsorption, whereby a wide array of nonspecific inflammatory mediators/cytokines can be tailored to an individual patient's needs (i.e., with add on cartridges). Moreover, with respect to other depurification techniques (such as high volume hemofiltration or plasma exchange), there can be selective removal of toxins or mediators but also reinfusion of physiologically important substances such as albumin, amino acids, and hormones.
[0028]Further aspects and advantages of the present invention will be apparent from the following description of several practical embodiments thereof given by way of non-limiting examples.
[0029]A high permeability plasmafilter is used which is made from the biocompatible material polyethersulfone. Additionally, a normal commercially available hemofilter is used. A cartridge containing 140 ml of divinylbenzene styrenic resin (Rohm Haas Amberchrom resin CG 300) with a pore size of 300 Å is used.
[0030]Table 1 shows the retention results obtained with different protein and mediators in human plasma samples of three septic patients.
TABLE-US-00001 TABLE 1 Monocyte Macrophage Inter- Inter- Inter- chemotactic infiammatory metallo- leukin leukin leukin protein protein 1β proteinase-3 6 IL-6 8 IL8 10 IL10 pg/ml pg/ml ng/ml pg/ml pg/ml pg/ml Patient 1 pre cartridge 1330 408 28 270 437 269 post cartridge n.d. n.d. n.d. n.d. 5 11 Patient 2 pre cartridge 196 345 5.3 55 60 14 post cartridge 14 153 n.d. 9.5 54 0.8 Patient 3 pre cartridge 71 100 50 7.3 25 13 post cartridge n.d. 4 3 n.d. 10 1.8 n.d. = below level of detection
[0031]In vitro studies were done with human plasma containing added cytokines and mediators to determine affinities for different types of resins. Plasma was used to simulate the effluent of blood from a plasma filter having a sieving coefficient above 0.8 for human albumin. The flow of the blood would be between 100 and 200 ml/min while the flow of the plasma would be determined as a fractional filtration between 10 and 20% of the blood flow. The plasma filter would be used in series with a second filter for hemofiltration having a sieving coefficient below 0.1 for albumin (in order to remove small molecules not adsorbed by the resin or to maintain patient volume control). A cartridge containing 140 ml of divinylbenzene styrenic resin (Rohm Haas Amberchrom resin CG 300) with a pore size of 300 Å could be combined with other cartridges (listed in Table 2) in series for specific or nonspecific removal of inflammatory mediators, in particular, Interleukin 6 (IL-6), C-reactive protein (PCR) and Kallikrein (KK).
TABLE-US-00002 TABLE 2 Particle size Pore size Resin No. Resin (μm) (nm) 1 Toyopearl CM-650C 100 100 2 Toyopearl HW-40C 75 5 3 Toyopearl Mega 200 50 CAP ® SP-550EC 4 Toyopearl SP-550-C 100 50 5 Toyopearl35 Super SP 40-90 6 CG71S 35 250 7 CG161M 75 150 8 CG300M 75 300
[0032]5 ml of human plasma containing IL-6 (100 pg/ml), PCR (0.5 mg/dl) and KK (0.5 mg/l) for 4 hours was incubated with 1 ml resin. Samples were taken at 0, 60, 120, 180 and 240 minutes.
[0033]The obtained results are shown respectively in FIGS. 1, 2 and 3.
[0034]In particular, from FIG. 1 it is evident that resins 6, 7 and 8 have a good affinity for IL-6. The same behavior is observed for PCR (FIG. 2). On the contrary, KK is seen retained with resins 2, 3, 7 and 8 (FIG. 3).
[0035]A high permeability plasmafilter, an hemofilter and a cartridge as in Example 1 are used.
[0036]Blood and plasma levels of VEGF are measured in 3 septic patients (normal ranges of VEGF are up to 55 pg/ml). Samples to determine VEGF amounts are taken at different time intervals; i.e., whole blood at time 0, plasma at 15 minutes prior to exposure to a filtration cartridge, and plasma at 15 minutes after exposure to a filtration cartridge. The results are expressed as VEGF pg/ml and are shown in Table 3.
TABLE-US-00003 TABLE 3 VEGF concentrations (pg/ml) Patient 1. Patient 2 Patient 3 Blood (time 0) 1490 1060 239 Plasma 15' pre cartridge 1720 708 233 Plasma 15' post cartridge 80 16 31
Patent applications by Mauro Atti, Bologna IT
Patent applications by BELLCO S.r.l.
Patent applications by SORIN GROUP ITALIA S.R.L.
Patent applications in class Including ion exchange or other chemical reaction
Patent applications in all subclasses Including ion exchange or other chemical reaction
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Objective: To observe the effect of modified guizhijiahoupoxingzi Decoction clinical efficacy of the treatment of cough variant asthma. Methods: 100 cases were randomly divided into treatment group (60 cases) and control group (40 cases), treatment group treated by Guizhi Houpo Xingzi Tang Jiawei, and those in control group were given aminophylline tablets, inhalation fluorine propanoic acid and fluticasone propionate, a course of 2 weeks. Results: the total effective rate nike Cortez 2015 of the treatment group was significantly different from Nike Cortez that of the control group (P%26lt; 0.05 or P%26lt; 0.01), and the adverse reaction and recurrence rate were significantly lower than those in the control group (P%26lt; 0.05).


text:
I watched a documentary about the legendary record label from Chicago, Chess Records, and decided to make a little commemorative poster.
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My first "serious" logo I've done in Illustrator. Took the time to learn grids and custom type.
It's a logo for a personal project I want to start: NinjaThemes. (Yes, another themes site.)
Don't forget to check out the grid and larger attachments!
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IBM to link Caterpillar with its suppliers
Caterpillar has brought in IBM to handle systems integration on a major manufacturing collaboration initiative.
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Business applications
How businesses can win talent war with mobile apps, HR data analytics and cloud technology
Latest articles on HR best practices: mobile apps disrupting the annual staff appraisals; reasons for and against open-source software; and Rolls-Royce case study.
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Caterpillar, the US-based manufacturer of construction and engineering equipment, plans to use i2 Technologies' supply chain applications to share information with its suppliers. The initiative is part of an effort to reduce inventories and shorten manufacturing times.
Integrating Caterpillar's systems with those of its suppliers is the responsibility of IBM's professional services division. According to Bruce Anderson, managing principal for industrial sector consulting at IBM, supply chain collaboration marks a huge opportunity for services firms.
"When you choose to collaborate, you cannot escape the fact that you've now changed the business process," he said. "Different people have to be notified and different actions triggered, and you have to be able to describe those processes to the middleware so it can send things to the right place."
IBM's WebSphere application server will handle the project's middleware functions. Anderson said such projects might also prompt IBM to change the way WebSphere is priced and designed.
"We're going to have to be flexible, because there's no one-size-fits-all way to set up a collaborative network," Anderson said.
Caterpillar plans to start linking suppliers to its network by the end of the year.
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Read more on Business applications
Gulf Air tinkers with Oracle suite and explores hybrid cloud models
'Considerable risk' if Post Office replaced Horizon system, says chairman
SuiteWorld 2016: Focusing on customer experience dragged us away from the call centre, says Aspect
European IT buyers prioritise BI and data management over ERP and CRM


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realmagick.com The shrine of knowledge.
Mali Economy
A selection of articles related to mali economy.
Original articles from our library related to the Mali Economy. See Table of Contents for further available material (downloadable resources) on Mali Economy.
- Survivalists' Guide for the New Millennium: Forward
- We live in the midst of a crisis so immense it boggles the poor, overloaded mind of modern humanity. The people of the world cannot seem to grasp its implications. Like a billboard whose message and image are stretched to such vast proportions that it fills...
Philosophy >> Survivalists Guide for the New Millennium
- The Celtic Vedic Connection, Part I
- Of all the great ancient cultures perhaps no two share more parallels than those of the Celtic and Vedic peoples. A deep rooted affinity runs between them, what is present in one is mirrored in the other. Myths, Gods, Goddesses, even fairy tales bear a...
Religions >> Druidism
- 14 - Art
- The word Art refers to the alchemist art of transforming matter through purification from an imperfect state into a perfect one. This was done by first analysing and transforming the different elements and then mingling opposites in the right proportions. But...
Tarot Cards >> The Major Arcana
- Gold
- Planet: the Sun Sign: Leo Day: Sunday In most cultures gold is associated with riches, rulership and truth. We are still told that paper money is backed (?) by gold. Here we see the analogy: gold forms the center of the economy, the throne and crown of the...
Earth Mysteries >> Stones, Minerals & Metals
- Software of the Mind #2: Adopting Natural Software
- Connection with Nature faded away as humanity removed itself physically and mentally from natural living. Thought replaced direct knowledge, (intuition) and ego replaced the mode of the natural mind. This is becoming increasingly the case not only at the...
Mystic Sciences >> Mind
Mali Economy is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Mali Economy books and related discussion.
Suggested News Resources
- Mali economic growth to rise to 6 pct in 2016: economy ministry
- BAMAKO (Reuters) - Mali's economy will grow 6 percent this year, bolstered by agricultural and mining production, the ministry of economy and finance said on Tuesday, up from an expansion of 4.9 percent in 2015.
- Al Qaeda gunmen drank beers before Ivory Coast attack
- President Ouattara won a landslide election victory in October, promising to attract foreign investment to the largest economy in French-speaking West Africa which is also the world's top cocoa producer.
- China is looking to have some of Nigeria's oil
- In an interview with the News Agency of Nigeria (NAN) in Abuja, the Economic and Commercial Counsellor of the Chinese Embassy in Nigeria, Mr.
- World Digest: March 13, 2016
- Gunmen killed 16 people at a popular beach resort in the West African country of Ivory Coast on Sunday, according to the nation's president. Witnesses said the six assailants wore all black and targeted civilians at the Grand Bassam beach.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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text:
A Recent Favorite:
Brevity by Dan Thompson
- May 10, 2016
- From Beginning
- Previous feature
- Next feature
- Current
Recent Comments
It takes a lot of balls to golf the way I do
yeah, guns don't kill people. People kill people……. with guns
as a Canadian i want to say, that Liberal or Conservative, Democrat or Republican, we can all agree that our soldiers deserve our respect and gratitude for what they go through.Wars are never started by the grunts in the field.
apparently the Araucana chicken only lays blue eggs, and only the mixed breed mongrels lay pastel eggs. Someone got ripped off……..
Ruthie's a rescuer
great, another online bully. She's starting to really annoy me.
Split personality is not Schizophrenia. I wish people could get that right.. Aren't newspaper editors supposed to know this stuff
worst writing ever. Puerile and reads as if it's written by a ten year old with a dirty mind.


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Economic Integration, Wage Policies and Social Policies
This paper uses a two country trade and geography model of monopolistic competition to study the effects of wage policies and social policies on the location of industry. It is first shown that a union wage push in one of two otherwise identical countries induces a relocation of firms which increases with the level of economic integration as measured by trade costs. This 'traditional view' is then contrasted with a 'new economic geography view' in which one of the countries has historically emerged as the core. The agglomeration rent which accrues to the mobile factor gives unions and governments in the core scope to set higher wages and to choose more generous welfare policies than their counterparts in the periphery without having to encounter an exit of firms. The relationship between the maximum international union wage differential and the level of integration is shown to be bellshaped.
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|22 pages
|Date of creation:
|Apr 2003
|Date of revision:
|Publication status:
|published in: Oxford Economic Papers, 2004, 56 (1), 135-150
|Contact details of provider:
| Postal: IZA, P.O. Box 7240, D-53072 Bonn, Germany
Phone: +49 228 3894 223
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Gain Fireworks
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realmagick.com The shrine of knowledge.
- Talthybius was herald and friend to Agamemnon in the Trojan War. He was the one who took Briseis from the tent of Achilles. Preceding the duel of Menelaus ...
- Talthybius With Eurybates, Talthybius served as Agamemnon's
- which probably originated in early epic, Talthybius went with Odysseus to try to ... it was Talthybius who removed *Orestes to safety when Agamemnon was.
- mythreligion.philology.upatras.gr
- HECUBA by Euripides translated by Jay Kardan and - Didaskalia
- Jay Kardan and Laura-Gray Street. POLYDORUS. HECUBA.
- www.didaskalia.net
- PDF of the Script
- Talthybius. The Greek Soldiers. Note: The Professor and Students #1, #2, and #3 speak, as indicated, all the lines that are neither capitalized nor underlined in ...
- www.didaskalia.net
- The Trojan Women - Drama Geeks
- THE TROJAN WOMEN by. Euripides. Characters in the Play.
- dramageeks.astorialand.com
- The Trojan War Essay
- Nov 17, 2015 Euripides provides an example of this when Talthybius, a Greek, is heartbroken when he has to take the child of a mother to his deathbed, even ...
- users.wpi.edu
- Review: The Trojan Women, Bristol Old Vic
- Hecuba (Hannah Bristow), former Queen of Troy, attempts to hold the women together as they wait, in torn slips and combat boots, for the Greek messenger Talthybius (Alex York) to deliver news of their fate. Which Greek heroes' beds will they now warm?
- The Trojan Women at Obsidian Offers a Modern Overlay on an Ancient Tale
- Seared from the horrors of war, Lauren Hainley, as snarky herald Talthybius, undergoes a neat transition from P.R. flack to sympathetic apologist when she carries in the dead body of Hector's young son.
- "The Trojan Women," directed by Susan Shaughnessy, is currently being
- Queen Hecuba and the remaining Trojan women gather in the ruins, waiting for news of their fate. Talthybius (Austin Lucas) delivers it in a string of gut-wrenching proclamations. Hecuba is to become the slave of the hated Odysseus, spending her old age ...
- Review: The Imaginists Take On the Trojan Women
- In Euripides' play, the Greek herald Talthybius delivers message after message to the women, each one a touch more devastating than the last. In WarCircus, he's a beleaguered circus master tasked with keeping the act going by order of a vengeful and ...
- Play on Words' ambitious 'Women of Troy' is compelling, modern adaptation
- Other than a brief appearance by Menelaus the Spartan king whose abducted wife was the cause of the war, the only speaking Greek to appear is the herald Talthybius, who delivers messages to the Trojan woman from the victorious offstage Greeks.
- Talthybius - Wikipedia, the free encyclopedia
- Talthybius was herald and friend to Agamemnon in the Trojan War. He was the one who took Briseis from the tent of Achilles. Preceding the duel of Menelaus ...
- en.wikipedia.org
- Talthybius in the Trojan Women - JStor
- TALTHYBIUS IN THE TROJAN WOMEN. In the many discussions of the structure and meaning of. Euripides' Trojan Women, the character and function of the.
- www.jstor.org
- Talthybius in Euripides' Troades - Greek, Roman, and Byzantine
- Talthybius in Euripides' Troades. M. Dyson and †K.
- grbs.library.duke.edu
- Talthybius
- In Greek Mythology Talthybius was herald and friend to Agamemnon in theTrojan War. He was the one who took Briseis from the tent of Achilles. Preceding the ...
- www.mlahanas.de
- Talthybius (Character) - IMDb
- Talthybius (Character) on IMDb: Movies, TV, Celebs, and more...
- www.imdb.com
Talthybius is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Talthybius books and related discussion.
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My work focuses on Human-Robot Interaction (HRI) and Brain-Computer Interfaces (BCI). My goal is to leverage software engineering, novel sensing technologies, and robotics to create tools and applications that enhance interactions between humans and robots. I use a combination of research in Human-Computer Interaction and BCI to study Brain-Robot Interaction (BRI). My BRI research centers on the design, implementation, and evaluation of HRI software applications that utilize neurophysiological measures to interpret human behavior. With this research I investigate the use of electroencephalogram (EEG) signals to control robots and evaluate users' state while interacting with machines. Work in this area aims to provide an efficient object manipulation alternative when hand mobility is restricted. This research also aims to assist with improving industrial human-robot collaboration.
This research investigates ways to utilize Visual Programming Languages (VPLs) with neurophysiological measurements of electroencephalogram (EEG) signals acquired with a Brain-Computer Interface (BCI). This data can be used to understand cognitive and affective states such as fatigue, cognitive workload, engagement, attention, and frustration. Using an interface equipped with a visual block-based programming environment enables users to interact with visualizations mapped to EEG data. Interacting with a drag-and-drop VPL allows users to dynamically utilize data streams captured from the BCI and quickly iterate on various visualization designs. See 'Using a Visual Programing Language to Interact with Visualizations of Electroencephalogram Signals' for more information.
The Brain-Drone Race is a competition featuring users' cognitive ability and mental endurance. During this event competitors are required to out-focus opponents in a drone drag race fueled by electrical signals emitted from the brain. On April 16, 2016, 16 participants competed using the Emotiv insight headsets and DJI Phantom 2 drones. Although others had previously demonstrated drone manipulation via EEG, this was the first public demonstration of a competitive Brain-Drone event. For more information visit www.braindronerace.com.
This work investigates a method of detecting tongue protrusion gestures by utilizing the tongue's color and texture characteristics. By taking advantage of recent advances in computer vision, real-time tongue gesture detection is possible with video streams provided by a standard web camera. Tongue gesture detection functionality has the potential to supplement user interaction and provide for an immersive experience in applications such as games or video communication applications. It could also aid communication for mobility-impaired users. See 'Using Cr-Y Components to Detect Tongue Protrusion Gestures ' for a description of a process presenented at the 33rd Annual ACM Conference on Human Factors in Computing Systems (CHI 15') that uses YCbCr color space manipulation and a support vector machine to detect left, right, and downward tongue protrusions in real-time.
Many members of the armed services are overseas during elections. As a result, they are unable to cast their ballot in person. Although the Uniformed and Overseas Citizens Absentee Voting Act (UOCAVA) gives soldiers located overseas the right to mail in absentee ballots, they are often left uncounted due to issues with shipping. This research investigates Televoting, an approach to Internet voting (E-Voting) modeled after Telemedicine systems that utilizes video communication technology. Televoting attempts to address security issues that have plagued previous E-Voting platforms by producing a paper ballot instead of storing votes on a server. See 'Televoting: Secure, Overseas Voting' for a discussion of the system design and the voting process users experience when using Televoting.
Unmanned robotic systems are being used in the military for surveillance and reconnaissance missions. However, current systems utilize a one (or multiple) operator/one robot interface. In addition, human-in-the-loop models or systems that have an autonomy component create issues because human operators tend to intervene more frequently if their expectations of the autonomy are not met. This research investigates the impact spatial and temporal cues have on operators' trust in human-multi-robot systems. See 'Affecting operator trust in intelligent multirobot surveillance systems' for a discussion on the system design and the voting process users experience when using Televoting.


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Radiohead, Morrissey, and Faithless have been confirmed as headliners for this year's V Festival, with Beck, Paul Weller, The Magic Numbers, Keane and Kasabian among many more also announced...
Morrissey and Faithless will co-headline one of the days with Radiohead closing the other. Organisers have not revealed whether the Oxford rockers will be sharing headlining duties with another act.
Other bands confirmed for the twin-sited festival include Editors, Groove Armada, Bloc Party, Starsailor, The Charlatans and The Ordinary Boys.
Fatboy Slim, The Go! Team, Orson, James Dean Bradfield, Sugababes, and The Feeling are the remaining acts confirmed.
V Festival 2006 takes place at Hylands Park, Chelmsford, Essex, and Weston Park, Staffordshire, on 19-20 August with two bills swapping sites over the two days.
Click here for more on the festival, including last year's coverage.
More than 60 acts are still to be confirmed for this year, with James Blunt, Massive Attack, Hard Fi, The Like, Seth Lakeman, and Kubb among those rumoured to be getting a slot.
Tickets for V Festival 2006 go on sale here at 9am this Friday (3 March) priced £120 for weekend camping, £100 for weekend without camping, £58.50 for day passes.
On hearing the Radiohead confirmation (rumoured on VF since December), one enraptured reader emailed VF to say: "To be in Thom Yorke's presence, to hear him sing like a blackbird on a spring morning, to watch him do his little rabbit dance around the stage, to hear new radiohead stuff, to watch Johnny and the other make musical magic…ahhh, I am sooooooo excited! (I am not 'obsessed' just 'in love')".


text:
Dr. Ed Zullo 609-439-8138
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What we treat
- Allergies
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"All of humanities problems stem from mans inability to sit quietly in a room alone". – Blaise Pascal
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text:
Keeping the Spirit of Elvis Alive
Villa La Paz Center for Destitute & Sick Children
Friends, please join me in supporting an amazing organization, developed by Florida's own Dr. Tony Lazzara who continues to provide love and care for Destitute and Sick Children along with his wonderful staff who devote their time and expertise, their love and caring for these very special children.
Please click the graphic to learn about the care provided for the children at Villa La Paz. These children are in desperate need of our continued love and support.
Together we can make "A DIFFERENCE IN THE LIVES" of these children. Please make a donation.
Thank you for your love and support.
Randy Elvis Walker
All donations received by the Villa La Paz Foundation are used to fund Hogar San Francisco de Asís (Home of St. Francis of Assisi), our home for destitute, ill children in Peru.
During 2012 the home spent between $34,000 and $35,000 per month. The foundation has no fixed income and depends solely on the generosity of its benefactors.
Your kindness and generosity is making life more than just an existence for our children. Thank you for your support.
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text:
If you'd just like the QuickNotes version of my Superstars review, just skip to the next slide. If you'd like a segment-by-segment breakdown, complete with predictions and questions, click through the remaining slides.
A few years back, I was a concert promoter in Des Moines, Iowa. The music scene wasn't enormous in Des Moines, and there was already a promoter working the kinds of shows that I was interested in. So I ended up working mostly with local and regional bands, and a few struggling national acts.
It was always my hope that a few of those bands would go on to much bigger things, remember me as they came back through Des Moines and help me grow as a promoter while they grew as a band.
After a few fun years of putting on shows and not making any money, I grew impatient and stopped promoting shows, leaving whatever small niche I had carved out to those who were already way ahead of me.
But I still enjoy seeing a lesser-known band that I enjoy finally make it big. It's a good feeling to see a struggling artist you supported finally achieve some success.
That same sort of attitude is also true for me in terms of professional wrestling.
In 2008, I would have told you that my favorite superstar was Randy Orton. When I was in attendance at WrestleMania 24, and I witnessed him steal a championship match from the likes of John Cena and Triple H, I was ecstatic.
That victory helped cement Randy Orton's spot as one of the elite superstars in the WWE. At WrestleMania 24, to a certain extent, Randy Orton peaked. He had made it to the top, and has remained there ever since.
Today, my favorite superstars are guys like The Miz, Dolph Ziggler, Sin Cara, Cody Rhodes and Daniel Bryan. These guys are all at different spots on the journey to their peak, and they all have the potential to be one of the elite someday.
The regulars on WWE Superstars are like the bands I used to work with. The casual fan may not be familiar with them, and probably couldn't tell you the last time they saw the Superstars-regular win.
That's because the regulars are still trying to establish who they are.
Let's take a fresh look at WWE Superstars, the May 31 edition, and see if this showcase of up-and-coming stars is worth our time.


text:
This hotel has its own restaurant serving breakfast and dinner where you'll find a selection of items to try. Free WiFi is available.
Hotel Info: 1-877-214-4288from $47
- Double Room, 1 King Bed
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- This hotel has 116 rooms
- This hotel is arranged over 3 floors
- Check-in time 2 PM-5:30 AM
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
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Travelling with others
- No cribs (infant beds)
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
In the hotel
- Buffet breakfast daily (surcharge)
- Restaurant
- Coffee shop/café
- Room service (during limited hours)
- Number of meeting rooms - 3
- Conference space size (feet) - 2044
- Conference space size (meters) - 190
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Year Built 2010
- Elevator/lift
- In-room accessibility
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Minibar
- Soundproofed rooms
- Private bathroom
- Bathtub or shower
- Free toiletries
- Hair dryer
- Flat-screen TV
- Desk
- Free WiFi
- Phone
- In-room safe
- Connecting/adjoining rooms available
Special features
DiningLas Dunas - This restaurant specializes in Mediterranean cuisine and serves breakfast and dinner. Guests can enjoy drinks at the bar.
Hotel Eurostars Arenas de Pinto - Pinto's small print
Also known as
- Eurostars Arenas
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Guests must contact this hotel in advance to reserve a crib (infant bed) or a rollaway bed. Contact the office using the information on the reservation confirmation received after booking.
Cash transactions at this property cannot exceed EUR 2500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Optional extras
Buffet breakfast is offered for an extra charge of EUR 8 per person (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.