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To all lolicons, what about real life loli?
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Oct 9, 2008 8:10 PM
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Your not thinking about parol are you? ;)
Oct 9, 2008 8:17 PM
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Posts: 5252
It is sick and wrong on so many levels, and not just because of the trauma it can induce. Though it's also worth mentioning that underage girls, if savvy enough, can sometimes be even worse than the sexual predators themselves thanks to the powers of both manipulation and the double standard. And I'd personally imagine there are quite a lot of minors who'd be perfectly willing to use such a relationship to their own advantage.
Oct 9, 2008 8:19 PM
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wtf D:
Oct 9, 2008 8:33 PM
Oct 9, 2008 8:34 PM
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Nice private photobucket, guy.
I wonder how many more of those you have...
Oct 9, 2008 8:42 PM
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ZinnKid said:
Flibbertigibbet said:
be_loved said:
Drybananna said:
LadyShiva said:
I love Children in general in any form
better looking than u
Oct 9, 2008 8:43 PM
Oct 9, 2008 8:57 PM
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That's an adorable pic OP, but seriously, hell fucking no.
My first novel, Kardia has been published! Click here to read!
Oct 9, 2008 8:59 PM
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sikkkke said:script.
ZinnKid said:wonder how long that took
Perelman, martyr
Oct 9, 2008 9:02 PM
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^ best script ever
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Oct 9, 2008 9:12 PM
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the_seventh_l said:The actual copypasta:
^ best script ever
Modified by ZinnKid, Dec 14, 2009 10:31 AM
Oct 9, 2008 9:26 PM
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Razma said:Back it up, the burden of proof is yours. I don't even have to show sources, that's the funny part, the burden of proof is yours.
This shit is getting out of hand now, why the hell are we posting pics of little asian girls with swimsuits?
And khorven, there's an age limit for certain things for a reason. Young people have no real life experience, they make quick, rash decisions based on whatever emotions they are experiencing at the time. A 12 year old girl and an 18 year girl have 2 totally different mindsets, saying that age doesnt matter is a cop out for your sick ass fetish. It takes years to figure out how your body really works, and how sex is going to effect you physically and emotionally, and a lot of people who have sex before they are ready scar themselves, a lot dont even realize that they have done it either. Children consenting to adults is not a consent out of a sexual desire, its out of a desire to please a person they trust and admire most of the time, and when the adult takes advantage of that, it is one of the worst thing that is possible.
Razma said:Same shit, burden of proof is yours.
And you base this shit off of 'Classical Greek and Rome', what a load of shit, saying that it doesn't cause any 'psychological Trauma to them', now how do we know that? Did people study the reactions of kids while they were getting forced to wed/sex at age 10? Kids who have sex at a young age with an adult do suffer from relationship issues, trust issues and a number of other effects. The truth is children cant make the decision about sex, shit half of the adults in the world cant make a rational decision when it comes to sex, and children are by far the worst to place in a position of that.
Razma said:Ain't we having a self-fulfilling prophecy here? You make your opinion up without knowing the situation here? She hit on me, not the reverse, like I said in that topic, I knew her from the nets and I didn't know she was twelve until it was too late, now that would be hypocrite of me to to back of then. I already knew her personality but would be scared by her twelve year old looking exterior? If I did that I could never again claim to not go for appearance. Besides, it's the Netherlands, same sex marriage, marijuana, euthanasia? Twenty per cent of this country lost its virginity by the time they were thirteen. The really funny part is that I'm still a virgin in my early twenties because I didn't want to do it but she wanted... bet you didn't expect that. I believe I also said some-where already that I was a virigin.
After reading about your own 'loli' which you seem so proud of, all it shows is how weak and pitiful a person can be. You say you have no morals, but we both know thats not true, on some level you know what you suposedly did with this 'loli' was wrong (i say suposedly because honestly I think you are starved for attention and thats why you pick abstract topics to rattle about). You wont admit it I know, you will more than likely have some big essay ready for me to read when I check again, telling me to mathematically prove that a 12 year old cant make a decision or some bs. But when the smoke clears all that is left is the fact that you are a sick fuck my friend, and I hope you grow up one day and dont end up being a pedaphile like you are quickly approaching.
Oh, and just to end it:
source. It shouldn't even be necessary as the burden of proof is yours, but whatever, consider yourself another hypocrite of the same levels as those who opposed female suffrage... but that doesn't make you any sub-mediocre, believe me, it's human.. all men præ-Lucy Stone did so and you would do too if you were born then, just as people now for strange reasons think violent videogames are bad for children which was never proven, or sitting long being the computer causes RSI, which was also never proven.
A physicist says this about it:
"physicist" said:
"What this does, in essence, is it has a chilling effect on research," Byrd
said. "That is, once you declassify it, there's no reason to continue
studying it."
I think this is a pretty silly arguement. He argues as if it were an arguement about declassification of the concepts as a whole, but for as far as I understand, the only thing argued in the paper I linked was removal of them from the DSM as being paraphilia, or 'mental illnesses'. His point also doesn't hold; consider what happened to homosexuality after it was removed from DSM. No more studies were done ever since...? I find that hard to believe.
"If pedophilia is deemed normal by psychiatrists, then how can it remain
illegal?" Nicolosi asked. "It will be a tough fight to prove in the courts
that it should still be against the law."
Exactly. And we should be able to question those laws being right. This person is funny, she takes practising pedophilia being illegal as a REQUIREMENT in debating removal of the attraction pedophilia from DSM definitions, rather than using DSM as a source of information for creating such laws. In other words, she hangs on to an un-(or at least under-)arguemented law as an arguement to reject removal of pedophilia as being a mental illness. How silly can one be...
In previous articles, psychiatrists have argued that there is little or no proof that sex with adults is necessarily harmful to minors. Indeed, they
have argued that many sexually molested children later look back on their
experience as positive, Nicolosi said. [important]
"And other psychiatrists have written, again in scientific journals, that if
children can be forced to go to church, why should 'consent' be the defining
moral issue when it comes to sex?" she said.
But whether pedophilia should be judged "normal and healthy" is as much a
moral question as a scientific one, according to Nicolosi.
She acknowledges that sex at a young age is often looked back on positively according to some psychiatrists, and doesn't falsify that, but accepts it. As there is no remaining logical ground to reject it, she says that despite this evidence, she'll hang on to her (unfounded) morals. Now this is a big person in the science called "psychiatry".. Wow.
In a fact sheet on pedophilia, the APA calls the behavior "criminal and
That it is criminal is irrelevant, the law is subject to change and cannot be used to argue whether an attraction is 'right' or 'wrong'. That it is immoral is also subject to change, and definately not something that is solid or inherently true. In other words: the APA just said "we do not like pedophilia". Nothing more, no further value can be added to this statement, except that current society (with no further arguements) apparently agrees with them; for the law and morals are that way. It's only an observation on how we feel about it, not a guideline about how we should feel about it.
Some years ago, the APA considered the question of whether a person who had
such attractions but did not act on them should still be labeled with a
"We clarified in the DSM-IV-TR...that if a person acted on those urges, we
considered it a disorder," Regier said.
According to DSM, people that have sexual feelings for children and do not act on them, are not pedophiles. :lol:
Another compelling arguement in favor of maintaining paraphilias in DSM:
"Getting rid of the paraphilias, which would mean getting rid of pedophilia,
that would not happen in a million years."
His reasoning is stunning. "We must not remove it, because we will never remove it."
APA is a joke, from what I'm reading here. I'm imagining a room full of psychiatrists (which is a joke on itself) debating in the most moralistic country of all, which I believe is the USA. All being veteran psychiatrists and very protective of what they achieved through DSM and psychiatry. I think they are indeed so biased they are uncapable of drawing logical or "objective" conclusions on the matter.
The paper I linked was not objective, but it was sufficiently arguemented and I've yet to see them falsified by proper reasoning or valid arguements.
And no, I have no morals... I also am not affected by the 'dreadful human quality to præfer to believe what I præfer to be true, I also have extremely high resistance to imprinting, in fact, I have on various occasions completely turned my life perspective around at the singlemost sign of compelling counterarguments, what we debate her is one of them. I used to think that videogames were bad for children and I advocated censorship, until I saw the first research into it and then thought 'bullshit, change of opinion', I have no morals and no sense of 'decency', for all I care you fuck a demented granny in her eye socket as long as she doesn't disapprove.
And I'm still a virgin yes, which has nothing to do with morals, I'm simply not keen on getting naked.
Modified by nihlniisadxhai, Oct 9, 2008 10:07 PM
Perelman, martyr
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Oct 10, 2008 12:14 AM
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"These are the findings of a comprehensive survey by the Community Information, Empowerment and Transparency (CIET Africa) in November and December 2002."
"The study involved 269 905 pupils in Grades 6 to 11 in all language groups, across a range of schools and from all nine provinces."
This is an article that reported on the findings of the survey mentioned above. This does not classify with having sex with an adult, but does give evidence that children can become traumatized and also bring about worse causes by having sex at young ages.
"Some of the other disturbing findings included that, at 18, two out of every three children had had sex. Two out of 10 pupils did not believe condoms prevented pregnancy or other sexually transmitted diseases.
One in 10 said they believed sex with a virgin could cure HIV/Aids, and one in 10 had been raped in the past year. Three out of every 100 pupils thought that girls liked sexually violent boys and one out of every 10 thought that girls who got raped, asked for it, according to the study. "
This can only go to show that children are not mature enough to make decisions on whether or not to have sex at young ages. I mean it is pretty amazing the some kids find that you can cure HIV/aids by having sex with a virgin or even believing condoms don't provide safe sex. Kids wouldn't even be using condoms, I mean they don't exactly hand condoms out at school to 10 year old children so they can have safe sex. Should they, no they shouldn't. This study only proves that children can not make decisions with o0ther children, let alone an adult. Of course, an adult is more self-conscious than another child but the effects it can still have on one child can be pretty devastating. Plus, also proving that its all possible to spread sexually transmitted diseases even adds on to the trouble.
Oct 10, 2008 12:32 AM
Joined: Sep 2008
Posts: 1055
I challenge the notion that sex is supposedly a very complicated feat for a human to accomplish, sexual urge still is a primal one, I believe not on the cerebral cortex located, it has also been shown that mentally retarded patients at least know how to masturbate and even issue mating signals and try to provoke sex, these are often rated as having a 'mental age' of around ten, though that concept is pretty flawed.
url_elf said:Nope it's a reductio ad absurdum it says 'If going to church needn't be consent, then neither does sex, the latter is false, than also the former.' It is merely there to highlight how partial is it viewed, like 'forcing people into sex is _wrong_ but forcing them to go to church is apparently a_o_k.
"And other psychiatrists have written, again in scientific journals, that if
children can be forced to go to church, why should 'consent' be the defining
moral issue when it comes to sex?" she said.
I read that, and it sounds like consent isn't necessary for a sexual experience? That almost sounds like condoning rape, the way it's phrased, but I'm not going to jump to conclusions. In fact, reading this has piqued my interest.
Yetp, that is what my source also argues, however it takes the simple definition of psychological damage, id est testible conditions as 'harmful' and then shows by research that these do not occur.
khorven said:
the burden of proof is yours
I'M BITING. At least for now... I have midterm essays I should be getting to, that have zero to do with this.
This isn't a subject I've researched, but I have access to my university's e-Resources... I'll cite what I'm using, and try to include quotations, but I don't know that I can find free online versions of the articles/books I'm looking at.
From what I'm reading the ideas you're presenting aren't new to this field of study
Counselling Adult Survivors of Child Sexual Abuse p42 said:
Most of the clinical literature indicates that CSA [Child Sexual Abuse] is always harmful to the child, but a proportion of researchers claim the contrary (Baker and Duncan, 1985; Feinauer, 1989b; Kendall-Tackett, Williams and Finkelhor, 1993; Ussher and Dewberry, 1995; Woods and Dean, 1984), with some studies even asserting that CSA can be a positive experience for the child (Baker and Duncan, 1985; Woods and Dean, 1984). The latter studies argue that more harm is done by the reaction of adults and professionals to disclosure, and that this accounts for the traumatization seen in children.
The last bit reminds me of this
"Child Sexual Abuse p11 said:
The current knowledge base of child sexual abuse is largely atheoretical. In the absence of formal theories of child sexual abuse, however, we continue to frame ideas about the scope and impact of child sexual abuse. Where do these ideas originate? For lack fo a better reference, that is, formalized and empirically supported theories of child sexual abuse, ideas may originate from our primary reference point – individuals such as ourselves (Major 1987) … In other words, individuals define their expectations based upon the expectations of people like themselves, suggesting that the personal construction of a theoretical orientation is biased towards the sociocultural context of the individual.
With an atheoretical knowledge base, this personal construction of the reality of child sexual abuse is probably inevitable and has been an ongoing problem in the professional literature. In the absence of analyses of specific hypotheses concerning the origins of child sexual abuse, the conceptualization of its origins is left open to interpretation. Because the interpretations are necessarily informed (a) by the persons' referents (i.e. individuals most like themselves) (Major, 1987), and (b) the sociocultural environment within which the individuals reside, these theories or hypotheses are often biased and, at best, reflect only a partial truth.
To put this in a sort of context... After the first quotation, the text went on to describe difficulties in the field, namely, that CSA is viewed as harmful to the child but what is harm? And who decides that it is harmful? The child, with whatever they take away from the experience? The professionals? The abuser? Society? This segues to the second quotation, that definitions are socially constructed, and thus, you get a variety of interpretations and perceptions. And, when reading literature, you have to look athte definition of CSA being used and the sample group being used. Does the group acknowledge the abuse? Are they reluctant to talk about it? It's difficult to gather empirical data...
Anyway, this brought to mind very much the latter quotation. So far, what I've gathered from this reading is that...1: That is what I wish to counter of course. 2: Not necessarily, one may take in mind that the children who indeed indulge in this have a more 'fuck the world' mentality and thus receive lesser to non damage from social reactions around them.
- Child sexual abuse is, to an extent, socially constructed or framed
- It's effects can be seen as positive or negative (depending on the researcher you're talking to!)
Counselling Adult Survivors of Child Sexual Abuse p43 said:
That CSA has an impact on children is unquestionable. What is disputed is the direction of that impact - positive or negative. The impact is not only sexual but also emotional and psychological. This si particularly the case when sexual grooming has taken place of the abuse has occurred within the context of a perceived loving family. When affection and sexual abuse, and love and pain, are entwined, reality can become distorted, creating illusions and misperceptions. Many children feel they are unable to trust their own perceptions about what is being done to them and what is appropriate and what is not. They can no longer trust themselves or those who purport to love or care for them. They become confused about how to feel, whether to listen to the inner hurt, pain or confusion, and whether to 'enjoy' the abuse because that is what the abuser wants or demands. This is compounded if the child experiences sexual arousal and enoys the stimulation to the point of orgasm. The child may feel betrayed by his body in responding to sexual contact or believe that because he took pleasure from the CSA, then he must have wanted to be abused.
A glaring failure in the articles that the OP listed to me was that they neglected to include the emotional state of the child with which sexual contact has been initiated. They argued technical difficulties with the DSM and its definition of paraphilia, or how once DSM worthy activities/beliefs/orientations/whatever are now seen as normal, but neither article seems to actually articulate anything about the children (do the children want sexual relations? are they being harmed from not having them? is this worse for them?), just the people who want to have these relations with these children. The quote I started with, coming from the OP's second article,
"And other psychiatrists have written, again in scientific journals, that if
children can be forced to go to church, why should 'consent' be the defining
moral issue when it comes to sex?" she said.
shows disregard for the mental/emotional state of the child. The page 43 quotation above seems to imply an implicit confusion that goes along with sexual contact at such a young age in our specific society and culture. Because of these sociocultural beliefs of sex, it is inevitable that a child, at some point in life, feel confused and subsequently guilty, ashamed, or otherwise harmed by the experience. This seems to be regardless of consent.
Then it's extremely obvious no arm was done.
CASoCSA p65 said:
It is clear that CSA has an impact on the child and can lead to a number of long-term effects. It is crucial for clinicians to remember that CSA and its impact will vary enormously from individual to individual, and each experience is unique.
But what if the child doesn't perceive that's s/he has been abused? What if, as an adult, they don't count themselves as a survivor of CSA?
"CASoCSA p53 said:
A number of adult survivors of CSA who appear to be unaffected may present in clinical practice as highly functional in many areas of their life and yet feel that their interpersonal relationships are fraught with difficulties. These survivors may initially be hard to assess and diagnose, especially if they have no clear narrative memories of CSA.
[Talks about how these types of survivors are typically high achieving, organized, controlled, driven to succeed, austere, well dressed etc]
Internally, however, these survivors commonly feel empty. They may fear intimate relationships in case they are found out as frauds in being more vulnerable and fragile than they present exteriorly. It is in intimate interpersonal relationships that issues around power and control become re-enacted. Despite their high cognitive abilities, such adult survivors often feel emotionally impoverished. This may be because as children in trying to make sense of CSA, they consistently searched for cognitive meaning to contain and control the confusion of their emotional responses. It is almost as though their cognitive development was accelerated to the detriment of their emotional development.
My conclusion: even if "consenting" at the time, a child can not truly consent to a sex act (or benefit from) because they are simply biting off more than they can chew with regards to their own emotional responses (confusion, shame, guilt, whatever) - immediate or eventual - from their specific sociocultural situation. That, and the disregard of those wishing to engage in such acts with children for the long term emotional well being of the child lead me to believe that those advocating for the normalization of sexual relations with children are simply in it for themselves.
Edits made for spelling and clarity.
sucura said:Lawlwtf, has little to do with children, every-one in that region thinks that.. not only children.... you have to ban sex altogether there then, which is not a completely bad idea...
"These are the findings of a comprehensive survey by the Community Information, Empowerment and Transparency (CIET Africa) in November and December 2002."
"The study involved 269 905 pupils in Grades 6 to 11 in all language groups, across a range of schools and from all nine provinces."
This is an article that reported on the findings of the survey mentioned above. This does not classify with having sex with an adult, but does give evidence that children can become traumatized and also bring about worse causes by having sex at young ages.
"Some of the other disturbing findings included that, at 18, two out of every three children had had sex. Two out of 10 pupils did not believe condoms prevented pregnancy or other sexually transmitted diseases.
One in 10 said they believed sex with a virgin could cure HIV/Aids, and one in 10 had been raped in the past year. Three out of every 100 pupils thought that girls liked sexually violent boys and one out of every 10 thought that girls who got raped, asked for it, according to the study. "
This can only go to show that children are not mature enough to make decisions on whether or not to have sex at young ages. I mean it is pretty amazing the some kids find that you can cure HIV/aids by having sex with a virgin or even believing condoms don't provide safe sex. Kids wouldn't even be using condoms, I mean they don't exactly hand condoms out at school to 10 year old children so they can have safe sex. Should they, no they shouldn't. This study only proves that children can not make decisions with o0ther children, let alone an adult. Of course, an adult is more self-conscious than another child but the effects it can still have on one child can be pretty devastating. Plus, also proving that its all possible to spread sexually transmitted diseases even adds on to the trouble.
Perelman, martyr
Oct 10, 2008 12:39 AM
Oct 10, 2008 12:47 AM
Oct 10, 2008 1:03 AM
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Jimmy Nail
Born Mar 16, 1954
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James Bradford "Jimmy" Nail is an English singer-songwriter, actor, musician, film producer, film score composer and television writer. He has starred in numerous roles on television since 1983. He is 6 feet 3 inches tall and a Newcastle United supporter. He is most famous for his role as Leonard "O...
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This type of game will generate positive energy for Buffalo as it heads into its bye week and prepares for the final five games of the season. These are the five biggest takeaways from today's game.


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Added Caffeine Could Crash
WASHINGTON (AP) – Trail mix. Potato chips. And now gum.
With a growing number of foods boasting added caffeine for an energy boost, the Food and Drug Administration says it's time to investigate their safety.
The FDA's new look at added caffeine and its effects on children and adolescents is in response to a caffeinated gum introduced this week by Wrigley. Called Alert Energy Gum, it promises "The right energy, right now." The agency is already investigating the safety of energy drinks and energy shots, prompted by consumer reports of illness and death.
Michael Taylor, FDA's deputy commissioner of foods, said Monday that the only time FDA explicitly approved the added use of caffeine in a food or drink was in the 1950s for colas. The current proliferation of caffeine added to foods is "beyond anything FDA envisioned," Taylor said.
"It is disturbing," Taylor said. "We're concerned about whether they have been adequately evaluated."
Taylor said the agency will look at the potential impact these "new and easy sources" of caffeine will have on children's health and will take action if necessary. He said that he and other FDA officials have held meetings with some of the large food companies that have ventured into caffeinated products, including Mars Inc., of which Wrigley is a subsidiary.
Wrigley and other companies adding caffeine to their products have labeled them as for adult use only. A spokeswoman for Wrigley, Denise M. Young, said the company will work with FDA.
Food manufacturers have added caffeine to candy, nuts and other snack foods in recent years. Jelly Belly "Extreme Sport Beans," for example, have 50 mg of caffeine in each 100-calorie pack, while Arma Energy Snx markets trail mix, chips and other products that have caffeine.
Last November, the FDA said it had received 92 reports over four years that cited illnesses, hospitalizations and deaths after consumption of an energy shot marketed as 5-Hour Energy.
The FDA said it had also received reports that cited the highly caffeinated Monster Energy Drink in several deaths.


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Wine Maker Notes
After the grapes were gently hand-harvested, de-stemmed and crushed, the juice fermented in temperature-controlled stainless steel tanks, with an extended post-fermentation maceration that beautifully married flavors and tannins, giving our Emblem Napa Valley Cabernet Sauvignon its lovely, seamless texture. Malolactic fermentation in barrel, combined with 18 months aging in French oak, further concentrated the wine's rich cherry, dark berry, and cassis flavors, adding subtle
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Wine Review
To create Emblem Napa Valley Cabernet Sauvignon, we sourced grapes from Napa Valley's finest wine growing regions to create a blend that truly represents the entirety of Napa Valley - fruit from hillside vineyards at our Oso estate in Northeast Napa and Suscol Ranch in Southern Napa were blended with valley floor fruit from Oak Knoll and Wooden Valley. By blending fruit from Napa's volcanic hillside soils and the deeper alluvial soils of the valley floor, we accomplished our goal of crafting a wine that boasts a beautifully rounded mouthfeel and layers of rich, complex flavors.


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Analytical Performance and Clinical Utility of a Bioassay for Thyroid-Stimulating Immunoglobulins
The analytical performance and the clinical utility of a thyrotropin receptor (TSHR)–stimulating immunoglobulin (TSI) bioassay were compared with those of a TSHR-binding inhibitory immunoglobulin (TBII) assay. Limits of detection (LoD) and quantitation (LoQ), assay cutoff, and the half-maximal effective concentration (EC50) were measured. Dilution analysis was performed in sera of hyperthyroid patients with Graves disease (GD) during antithyroid treatment (ATD). Titer was defined as the first dilution step at which measurement of TSI or TBII fell below the assay cutoff. The LoD, LoQ, cutoff, and EC50 of the bioassay were 251-, 298-, 814-, and 827-fold lower than for the TBII assay. There were 22%, 42%, 23%, and 14% more positive samples in the TSI bioassay at dilutions of 1:3, 1:9, 1:27, and 1:81 (P < .0001), respectively. Responders to ATD demonstrated marked differences in titers compared with nonresponders. The bioassay detected lower levels of TSHR autoantibodies, and the dilution analysis provided similar predictive values of both assays in GD.
- Analytical performance
- Dilution analysis
- Thyroid-stimulating immunoglobulins
Graves disease (GD) is characterized by production of autoantibodies to thyroid-associated antigens such as the thyrotropin receptor (TSHR).1 The pathophysiology of the hyperthyroidism of GD is related to thyroid stimulatory autoantibodies (TSAb), also termed thyroid-stimulating immunoglobulins (TSI), that activate the TSHR on thyroid follicular cells, leading to unregulated thyroid hormone production.2,3 These functional autoantibodies mimic the receptor's natural ligand by stimulating cyclic adenosine monophosphate (cAMP)–dependent signal transduction, but other anti-TSHR antibodies antagonize the TSHR by either blocking TSH binding or interacting with TSHR epitopes that inhibit cAMP production.4,5
Currently, 2 different methods are used to assess the level of antibodies directed against the TSHR. TSHR-binding inhibitory immunoglobulin (TBII) assays detect immunoglobulins that inhibit the binding of thyroid-stimulating hormone (TSH), or the human monoclonal stimulating autoantibody M22, to purified or recombinant TSHR. Commercially available TBII tests display high sensitivity and specificity for TSHR autoantibodies but unfortunately do not measure the functional activity of immunoglobulins and do not differentiate antibodies with stimulatory, blocking, or neutral activity.6,7 TSI bioassays, in contrast, are specific for TSHR-stimulating autoantibodies since they are based on measurement of cAMP production in a cell line stably transfected with the receptor.6 Recently, it has been reported that TSI show more significant association with clinical features of Graves eye disease than TBII.8,9 Furthermore, the TSI bioassay was compared with a TSHR-binding assay in a study in which sera from patients with GD were tested following serial dilution into normal serum.10 Certain sera, which were positive by both methods, showed extinction of their binding activity between the 1:11 and 1:22 dilution but were still positive in the bioassay at a dilution of 1:300. These data suggest that the TSI assay can measure lower amounts of anti-TSHR antibodies in the sera of patients with GD.
To further evaluate the performance of the TSI reporter bioassay, we assessed autoantibody titers in hyperthyroid patients with GD enrolled in a prospective clinical trial of antithyroid drugs (ATD). We also compared the analytical performance of 2 commercially available anti-TSHR assays, a TSI bioassay and a TBII assay, using the thyroid-stimulating monoclonal autoantibody M22.11
Materials and Methods
Forty hyperthyroid patients with GD (mean ± SD age 44.8 ± 14 years; range, 21–76 years), of whom 31 (77.5%) were female and 16 (40%) were smokers, were prospectively followed for 36 weeks (24 weeks of treatment and subsequent 12 weeks of follow-up). Serum samples were collected both prior to as well as 4, 8, 12, 24, and 36 weeks after starting ATD treatment. GD was defined as the presence of hyperthyroidism (suppressed baseline serum TSH with increased serum-free thyroid hormone levels), positive TSHR autoantibodies, and a typical ultrasound imaging of a hypoechoic goiter. Methimazole therapy starting dose was 10 mg/d and 20 mg/d when serum-free thyroid hormone values were 3- or 5-fold increased, respectively. The dose of methimazole monotherapy was titrated every 4 weeks according to the serum-free thyroid hormone levels during the first 3 months and then at week 24 and, if required, at week 36. Response to therapy was defined as chemical euthyroidism (thyroid hormone levels in the normal range) at week 24 and persistent clinical and biochemical euthyroidism at week 36, 12 weeks after discontinuing ATD. Nonresponders to ATD were defined as hyperthyroid at week 24 and/or as having a biochemical relapse within the 12-week follow-up period. The trial was approved by the Ethical Committee of the Medical Association in the State of Rhineland-Palatinate, Germany, and all extensively informed patients gave their written consent prior to their inclusion in the study.
TSI and TBII Assays
TSI were measured with a US Food and Drug Administration (FDA)–cleared TSI reporter bioassay (Thyretain, Diagnostic Hybrids, Athens, OH), which was performed according to the manufacturer's instructions. The coefficient of variation (CV) of the triplicate measurement of a serum sample had to be below 15%. This TSI bioassay is based on Chinese hamster ovary cells (chimeric CHO-luc cells) that constitutively express a chimeric TSHR and contain a firefly luciferase gene downstream of a promoter containing cAMP-responsive elements as described previously.10
TBII were measured using the automated electrochemiluminescence immunoassay (ECLIA) (Elecsys Anti-TSHR Immunoassay, Roche Diagnostics, Mannheim, Germany) on the Cobas e411 analyzer (Roche Diagnostics). The measurements were performed according to the manufacturer's instructions. The ECLIA Elecsys uses the MAb M22 labeled with a ruthenium complex. TBII are detected by inhibiting the binding of M22 to an immobilized porcine TSHR. The calibration is standardized against the National Institute for Biological Standards and Control (NIBSC) 90/672 standard.12
Serial Dilution Analysis
The TSI bioassay was compared with the TBII assay using 237 serum samples from 40 patients with GD. Serial 1:3 dilutions were performed on each serum sample (200 μL) in triplicate into human TSI-negative control serum (400 μL) up to a final dilution of 1:81. For samples still positive at 1:81, the dilution was extended to a final dilution of 1:243, 1:729, 1:2187, or 1:6561. The titer was defined as the first dilution step at which the assay results fell below the cutoff.
Analytical Performance
TSI Bioassay
Dose-response curve. M22, a stimulating monoclonal antibody (MAb) (Kronus, Star, ID; 4 μg lyophilized), was dissolved in either 1 or 2 mL phosphate-buffered saline (PBS). Two-fold serial dilutions were prepared to achieve concentrations ranging from 0.003 to 100 ng/mL. Each M22 concentration was diluted in 1:11 control serum prior to testing in the TSI bioassay. All TSI values are expressed as percent specimen-to-reference ratio (SRR%), calculated with the following formula: SRR% (mean TSIspecimen/mean TSIreference) × 100. The mean TSIspecimen is the mean of triplicate luminescence relative light unit (RLU) measurements containing M22, and the mean TSIreference is the mean of triplicate luminescence RLU containing 0.1 IU/mL bovine TSH. The bioassay cutoff is an SRR of 140%.
Limits of blank, detection, and quantitation. The limits of blank (LoB), detection (LoD), and quantitation (LoQ) were determined according to the Clinical and Laboratory Standards Institute (CLSI)–approved guideline for protocols determining LoD and LoQ.13 The LoD was measured using 8 low positive M22 concentrations ranging from 0.09 to 0.005 ng/mL. Each M22 concentration was measured 20 times in duplicate. The LoB was measured 40 times in duplicate with 1:11 diluted control serum. The LoQ was defined as the lowest M22 concentration that could be reliably repeated with an imprecision less than 20%. It could be at the same or a higher M22 concentration than the LoD in accordance with the following weighting: LoB < LoD ≤ LoQ.
TBII Assay
Dose-response curve. M22 was diluted to prepare concentrations from 3.125 to 4000 ng/mL. All samples were measured in the Cobas e411 immunoassay analyzer (Roche Diagnostics) according to the manufacturer's instructions.
For the Elecsys Anti-TSHR Immunoassay (Roche Diagnostics; 510(k) number k080092), an LoB less than 0.5 IU/L, an LoD less than 0.8 IU/L, and an LoQ of 0.9 IU/L have been published (http://www.accessdata.fda.gov/cdrh_docs/reviews/K080092.pdf). The measurement range is 0.3 to 40 IU/L. Within-run precision testing gave CVs of less than 10%, less than 3%, and less than 4% for low (1.5-5 IU/L), moderate (5–20 IU/L), and high (20–40 IU/L) concentrations, respectively, whereas total precision testing showed CVs of less than 13%, less than 5%, and less than 6%, respectively.
Statistical Methods
With respect to the M22 dose-response curves for TSI, we report mean and 95% confidence interval (CIs) on the log 10 scale and, by raising these to the power of 10, the geometric mean with 95% CI for the metric scale in ng/mL. Each is based on 3 repeated runs, and calculations are based on means of 3 repeated measurements within each run. Calculations also are based on a Brain-Cousens14–type extension of the 5-parameter logistic model15 that allows for a slight decay of response beyond its maximum:
M22 dose-response curves for TBII were fit by first omitting all observations resulting in the upper measurement limit of 40 IU/L, which amounts to restriction to the dose range of 3.125 to 300 ng/mL. A 4-parameter logistic model for the log base 10 of dose (Morgan-Mercer-Flodin model) was fitted. We fitted the model to data of each of 5 runs, as well as determined the model parameters and concentrations corresponding to a response at 20 IU/L and 40 IU/L. The model-based half-maximal effective concentration (EC50) parameter is not reported because the measurement range is cut off at 40 IU/L. The concentration at a response of 20 IU/L (which is midway between 0 and the maximum) is referred to as EC50. For the determination of concentrations at an LoB of 0.5 IU/L, an LoD of 0.8 IU/L, an LoQ of 0.9 IU/L, and the reference limit of 1.75 IU/L, a linear fit to data for a dose ranging from 3.125 to 75 IU/L was used because it fits better over this restricted range. Positivity rates for each dilution were compared between TBII and TSI by counting the number of positive results per patient and dilution steps over all visits and comparing the resulting counts by the Student paired t test. Whenever they were adequate, Bonferroni-corrected test results are provided. The mean titers of TSI and TBII were compared over time by fitting a linear mixed model also including the interaction between assay method and time. We specified the assay method as a random effect and the repeated measures for each patient and week with an unstructured covariance type, allowing the variance of TSI and TBII to be different. Sandwich estimators for the fixed-effects parameters and respective t-type tests and 95% confidence intervals (CI) were calculated. Least squares means of the titer within each assay method and week were computed (also separated by response) and are shown graphically with their standard errors. All P values are 2-sided. The analysis was performed using the statistics software programs SPSS version 19.0 (SPSS, Chicago, IL) and SAS version 9.2 (SAS Institute, Cary, NC).
Analytical Performance
M22 stimulates cAMP production in chimeric CHO-luc cells in a dose-dependent manner Figure 1A. The concentration at which the assay cutoff level of 140% occurs is 0.017 ng/mL (95% CI, 0.004–0.068). The lower asymptotic limit was a mean ± SE SRR% of 111% ± 9%, and the upper limit was 593% ± 19%. Using these parameters, the EC50 was calculated to be 0.20 ng/mL (95% CI, 0.100–0.395).
The results of 80 blank measurements with 1:11 diluted control serum and 40 low M22 concentration samples showed a normal distribution (Shapiro-Wilk test). Therefore, LoB and LoD were calculated according to the following formulas: LoB = meanblank + 1.645 × SD meanblank, and LoD = LoB + 1.645 × mean SDlow concentration sample. LoB had an SRR of 76.1%, whereby the average of 80 blank measurements had an SRR of 59.9% and an SDblank of 9.8%. LoD had an SRR of 90.5% and an SDlow concentration sample of 8.7%. LoD and LoQ were both determined to be 0.02 ng/mL M22.
Dose-response curves were performed for M22 in the TBII assay Figure 1B. Measurement error (pooled over doses 3.125–300 ng/mL over 5 repeated runs) was 0.23 ng/mL (SD). Root mean square error (RMSE) for a linear model of log response fitted on doses ranging from 3.125 to 75 ng/mL was 0.21 ng/mL, which is similar to the overall measurement error SD. Mean ± SE LoB corresponds to 2.24 ± 1.18 ng/mL M22; LoD, 5.02 ± 1.17 ng/mL M22; and LoQ, 5.95 ± 1.16 ng/mL M22.
Over the unrestricted dose range from 3.125 to 300 ng/mL, a 4-parameter logistic model for the log base 10 of dose (Morgan-Mercer-Flodin model) fitted better (RMSE 0.29 IU/L for the pooled data) than a linear model (RMSE 0.52 IU/L). We fitted the model to data of each run and determined the model parameters and concentrations corresponding to a response at 20 IU/L and 40 IU/L. Means ± SE at 20 IU/L and 40 IU/L were 165.26 ± 1.26 ng/mL M22 and 371.96 ± 1.38 ng/mL M22, respectively (Figure 1B). The 5 fitted model curves highly agreed in the observed measurement range (up to 40 IU/L) but not beyond it. Unfortunately, the model-based definition of the EC50 depends on the upper limit of the fitted curve, because the abscissa corresponds to the mean between the upper and lower limits. The upper limits, obtained from the fitted curves, varied considerably, and hence the modelbased EC50 varied. For this reason, we instead report values corresponding to the responses at 20 IU/L and 40 IU/L. The cutoff value of the TBII assay is 1.75 IU/L, which corresponded to a mean ± SE M22 concentration of 13.83 ± 1.12 ng/mL.
Serial Dilution Analysis
A total of 237 serum samples were obtained from 40 thyrotoxic patients with GD prospectively followed at baseline and at weeks 4, 8, 12, 24, and 36 after ATD. Each serum sample was diluted and tested in both the TSI and TBII assays Figure 2A. There were 22%, 42%, 23%, and 14% more positive samples in the TSI compared with the TBII assay at dilutions of 1:3, 1:9, 1:27, and 1:81, respectively, with a mean percent difference of 25% (95% CI, 17%–32%; P < .0001). At a dilution of 1:243 and higher, results were positive only with the bioassay. The ratio of the positive TSI to TBII increased as the dilution increased such that the higher the dilution, the higher the positive TSI/TBII ratio Figure 2B.
According to the manufacturer's instructions (Diagnostic Hybrids), all serum TSI values were measured in triplicate and the CV was obtained. Mean ± SE CV values at dilutions of 1:9 and 1:81 were 5.4% ± 0.2% (205 serum samples) and 6.2% ± 0.3% (132 serum samples), respectively. In accordance with the manufacturer's instructions (Roche Diagnostics), we measured the TBII values once. Mean ± SE TBII values were 3.4 ± 0.4 IU/L (160 serum samples) and 1.7 ± 0.4 IU/L (28 serum samples) at dilutions of 1:9 and 1:81, respectively. These dilution results are within the low concentration range (1.5–5 IU/L) defined by the manufacturer (Roche Diagnostics) that previously published within-run and total precision testing values of CVs less than 10% and less than 13%, respectively.
The correlation between all undiluted TSI values and the corresponding titers is shown in Figure 3A. A steady increase was noted until a titer of 3. At a TSI titer of 3 and above, the undiluted values reached a plateau. Baseline mean ± SE TSI values at week 0 were similar in responders and nonresponders (373% ± 25% vs 377% ± 20%, respectively), whereas dilution analysis differentiated between the 2 groups. TSI titers of 3 or more were observed at least once in 33 of 40 (82.5%) patients and in 151 of 237 (64%) evaluated samples. In these samples, quantitative information was provided by dilution series but not by the undiluted samples (undiluted SRR% did not correlate with titer at that level). Once a "plateau" was reached above an SRR value of 400% corresponding to a TSI titer of 3, a clear differentiation of the SRR% values was possible with the help of the dilution analysis only. All nonresponders had a TSI titer of 3 and above.
In comparison, an exponential increase was noted for the TBII dilution curve reaching its plateau at a concentration of 40 IU/L Figure 3B. However, the plateau range of the bioassay was 3 dilution steps wider, and thus there were more values within the plateau. When analyzing titers as a function of time after ATD, both mean TSI and TBII titers demonstrated no change until week 12, followed by a linear decrease until week 36 Figure 4. In addition, the overall mean TSI titer was 1.13 dilution steps (95% CI, 0.84–1.42; P < .0001) higher than the overall mean TBII titer.
The serum thyroid-related hormone values (TSH, free T4, and free T3) of responders vs nonresponders at weeks 0 and 24 at completion of ATD treatment are shown in Table 1. During the 36-week observation period, a linear decrease of the TSI titer was noted in the ATD responder group (n = 20, 14 female, mean ± SD age 42.3 ± 14 years, 7 smokers), whereas an increase was registered at week 12 in the nonresponder group (n = 20, 17 female, mean ± SD age 47.3 ± 13 years, 9 smokers) Figure 5. In the nonresponders vs responders, baseline mean ± SE TSI titers were 4.0 ± 0.39 vs 2.9 ± 0.25 (difference 1.1; 95% CI, 0.19-2.01; P = .018), and mean ± SE TBII titers were 2.65 ± 0.29 vs 1.65 ± 0.16 (difference 1.0; 95% CI, 0.34-1.66; P = .003). The mean difference in TSI titers increased to 2.0 (95% CI, 1.23–2.77; P <.0001) at week 24, whereas it was 1.85 (95% CI, 1.24–2.46; P < .0001) for the TBII assay.
For the first time, this prospective study evaluates the analytical performance as well as the clinical utility and the predictive value of serial dilution analysis in patients with autoimmune Graves hyperthyroidism undergoing antithyroid drug treatment. In line with our previous report16 this is a further comparative study of an FDA-cleared chimeric TSHR TSI reporter cell-based bioassay and a widely distributed automated TSHR binding (TBII) assay. Compared with the TBII assay, the bioassay is able to detect lower levels of anti-TSHR autoantibodies and has a similar predictive value in the dilution analysis with serum of patients with GD.
Analytical Performance
Compared with the TBII assay, the TSI bioassay can detect lower amounts of a stimulating monoclonal autoantibody as indicated by the lower LoD and LoQ, assay cutoff, and half-maximal effective concentration. Interestingly, the large difference between the 2 assays in LoQ and LoD as measured using M22 was not reflected in the dilution analysis with patient sera. The TSI bioassay only detects stimulating autoantibodies that activate the chimeric TSHR, resulting in rapid signal transduction and leading to induction of cAMP and luciferase expression.17 Serum from a patient with GD can encompass a mixture of various antibody types with differences in both structure as well as function.18 The third-generation TBII assay (ECLIA Elecsys, Roche Diagnostics) uses a solubilized porcine TSHR and measures competitive binding activity of patient serum in the presence of a competitive agonist, M22 labeled with a ruthenium complex.19 The readout is an electrochemiluminescent light emission that is represented in IU/L based on a standard reference material.20 Stimulating, neutral, and blocking immunoglobulins bind to conformational epitopes of the TSHR within the TSH binding pocket.21 The assay measures the binding activity of all anti-TSHR antibodies and does not discriminate among the different functions of antibodies. The inherent differences in how each assay detects anti-TSHR antibodies might explain why the TSI bioassay exhibited greater apparent responsiveness to M22 compared with polyclonal patient sera. M22, isolated from lymphocytes of a hyperthyroid patient with GD, exhibits a powerful stimulating activity in vivo as well as in vitro.22 The antigen binding fragment (Fab) of M22 binds with high affinity to the TSH receptor23,24 and mimics properly the binding of thyrotropin. Furthermore, it is possible that blocking antibodies in the polyclonal sera of patients with GD bind to the TSHR and interfere with the measurement of stimulating antibodies by blocking the response of the chimeric CHO-luc cells.
Dilution Analysis and Clinical Relevance
In this original study, serial dilution analysis proved to be clinically useful in 64% of the prospectively evaluated serum samples, offering additional quantitative information to the baseline undiluted TSI values. In hyperthyroid patients with TSI levels above an SRR of 400%, determining the TSI titer further defines the level of TSI activity in the serum of these patients. Also, during the whole observation period, the differences of TSI titers between responders to ATD and nonresponders were slightly greater than the corresponding differences of TBII titers. Therefore, serial dilution analysis seems to be of clinical utility for treating physicians and in laboratories using the TSI bioassay during the management of thyrotoxic Graves patients. This could be acknowledged as an added value of the TSI bioassay vs its more complex methodology when proposed for its routine use as opposed to the TBII assay.
The TSI dilution titer of the nonresponder is foremost at 4 and above. This usually corresponds to undiluted values of an SRR of around 400% or higher. However, an SRR value of 400% is not a fixed line (ie, it might vary between 360% and 440%). This undiluted SRR range can also be assumed with a TSI titer of 3. Since baseline mean ± SE TSI values at week 0 were similar in responders and nonresponders, the dilution analysis (ie, TSI titers) provided an enhanced and statistically significant quantitative discrimination between responders and nonresponders. Thus, dilution analysis markedly improved the clinical relevance and predictive role of the bioassay and may be regarded as an additional informative diagnostic tool to evaluate the serological activity of GD.
No data comparable to those from this prospective design have been reported in the literature. Previous publications investigated the value of the level of anti-TSHR antibodies for predicting the response to ATD treatment,25–28 but the present report represents the first evaluation of the usefulness of serial dilution for predicting the outcome of therapy for patients with GD. Serum dilution has been performed in vitro to better characterize experiment results, but none of these studies drew clinically relevant conclusions.29–32 For example, the effects of graded dilutions of sera and IgG with known TSI activity were compared.31 Sera as well as IgG increased the cAMP production, but at the highest concentrations, an inhibitory effect was evident. In contrast, the serial dilutions performed in the present study were informative and clinically useful in more than 80% of the prospectively evaluated patients with GD, especially when looking at TSI values outside the linear range. Furthermore, both the baseline values as well as TSI titers during the course of therapy were clearly different in the responders to ATD medical treatment vs those who did not respond.
Considerations for Clinical Use of Both Assays in the Laboratory
Figure 3 demonstrates that the slope of the TSI curve (Figure 3A) is steeper in the range around the cutoff compared with the TBII curve (Figure 3B), which indicates that the quantitative discrimination of the bioassay is more sensitive at that level. Therefore, the bioassay might be recommended in cases where a low autoantibody level is expected. This applies to patients with mild and/or subclinical GD or with Graves hyperthyroidism of recent onset. Furthermore, and because of the risk of neonatal thyroid dysfunction in the newborn, accurate differentiation of the functional character of TSHR autoantibodies is keenly warranted during pregnancy as well as in the postpartum period. Finally, and as previously described, the close correlation of the TSI levels with the clinical activity and severity of Graves thyroid eye disease might offer additional relevant information compared with the serum TBII levels.8,9 On the other hand, the easier to handle binding assay measures TSHR autoantibodies at higher levels and at a broader concentration range showed by the M22 results. Thus, the TBII assay can be regarded as a useful tool for follow-up during and after specific antithyroid treatment.
We are grateful to Elisa Kolbe, study nurse; Sabine Niel, laboratory scientific associate; and Nina Matheis, MS, all at the Molecular Thyroid Research Laboratory, Gutenberg University Medical Center, Mainz, Germany, for data collection and fruitful discussion.
↵* Mr Leschik and Ms Diana contributed equally to this article.
Dr Olivo and Dr Li are Quidel employees. Dr Kahaly consults for and has received research grants from Quidel.
- © American Society for Clinical Pathology


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Society for Philosophy
Annual Meeting
The SPP sponsors an annual meeting, usually held in June. Meetings consist of invited lectures and symposia, contributed papers, and a Presidential address. Social events include a receptions and lunch meetings. SPP encourages suggestions for the invited portion of the program for upcoming meetings. These should be directed to this year's Program Chairs. We encourage philosophers, psychologists, and cognitive scientists more broadly to submit contributed papers to the meeting.
Diversity Initiatives
The SPP Diversity Committee holds sessions at the annual meeting. In addition, in 2011 there was a meeting, chaired by Valerie Tiberius and Carrie Figdor, regarding the APA-funded project to use SPP expertise to begin experimentally Studying the Gender Gap in Philosophy. The resulting report is was published in Hypatia in 2012, Volume 27 (4):949-957. SPP is also now offering a number of travel awards for graduate students to encourage diversity.
Past Meetings
* As a result of moving meeting time from fall to spring, no meeting was held between fall 1974 and spring 1976.
42nd Annual Meeting, June 2016
The next meeting of the Society for Philosophy and Psychology will be held 2-4 June 2016, with a pre-conference workshop on transformative experience and the self on June 1st, organized by Laurie Paul and Fiery Cushman. It will be held on the campus of University of Texas at Austin in Austin, Texas.
Hope to see you in Austin!
Schedule and Program
The SPP 2016 program is now up, and we also have a nice conference flyer!
Presentation Instructions
Poster presentations: We recommend a poster size of 3' (height) by 4' (width).
Registration and Dues Payment
Online Payments can be made by credit card or PayPal. You can join the SPP or pay your annual dues along with your registration. If you join, you get to take advantage of member registration for this meeting. For on-site registration, please go to the registration desk in the first floor lobby of the Seay Building (Psychology).
Housing for the Meeting
Conference housing is provided at the AT&T Center. Guests can now book rooms within the SPP block by calling the hotel at (512) 404-3600 and requesting the Society for Philosophy and Psychology room block.
Additionally, we've put together a list of alternative (and cheaper) housing options near UT Austin. You can find that here
Child Care
The suggested childcare provider is www.nannypoppinz.com, who provide the highest-rated childcare services in the Austin area. Their nannies are accustomed to care in hotels if needed and are all background checked and certified to provide all necessary care and transportation to other activities around town or to any place on campus. Fees for temporary nannies are a $40 per day agency fee, plus an hourly rate starting at $14-18 per hour paid to the nanny (depending on the number of children). Please contact firstname.lastname@example.com for more information.
Program chairs: Jonathan Phillips and Liane Young
Local arrangements chair: Cristine Legare
SPP Secretary/Treasurer: Tony Chemero


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Left Masthead
October 28, 2016
Video Memories of Mike Wallace
Posted on Apr 8, 2012
We should all be so lucky to live to 93, luckier still to have a career like that of Mike Wallace, who died peacefully Saturday night after roughly six decades on television.
Wallace was known for asking powerful people tough questions, some of which are captured in the videos below. —PZS
Here is Wallace on the first ever episode of "60 Minutes" in 1968:
1979: Ayatollah Khomeini:
1970: Coming and going to Vietnam:
Square, Site wide
1975-1989: The Reagan Interviews:
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I don't see the best interview of Mike Wallace in his carreer, Louis FARRAKHAN V.S Mike WALLACE (1996)


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As mentioned earlier, the objective of principal components analysis is to represent the rows and columns of a data matrix in a subspace of reduced dimensionality and to highlight the relations unseen by computations. Therefore the points of N ( i ) and N ( j ) in a p-dimensional subspace, generated by the first factorial axes, are plotted in a series of two-dimensional plots.
Variable points
Since the a -coordinates of the variable points, j of N( j ), are similar to correlation coefficient (or Cosine squared), these points can be projected on to a circle (called a correlation circle), whose axes are pairs of factorial axes. The variables are represented in a correlation circle.
Individual points
The points i of N ( I ) are projected on to a 2-dimensional factor space.
Joint Graphics
The points of clouds N ( I ) and N ( J ) can be projected on to the same graphic, though the meaning of both sets is not the same. The proximity between one point i of N ( I ) and point j of N ( J ) cannot be interpreted, because the points of N ( I ) are centered at G, the center of gravity of N ( I ), whereas the points of N ( J ) are centered at O (the origin of the row variables).
Graphics for Supplementary Elements:
The supplementary points can be plotted in the factor space generated by explicative factor axes. To avoid confusion, it is suggested that the symbols for supplementary and principal points should not be the same.
Interpretation of Graphics
Distances between individual points are interpreted in terms of similar patterns of response to the variables Distances between variables are interpreted (when using normalized principal components analysis) in terms of correlation. However, a great deal of caution is needed in interpreting the distance between a variable point and an individual point, because these two points do not belong to the same space. However, we can legitimately compare relative positions of two individuals with respect to the entire set of variables or two variables with respect to the entire set of individuals


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(VIDEO) Fire Erupts at the Beaver County Airport
Published On: May 14 2013 08:29:22 AM EDT Updated On: May 14 2013 08:29:30 AM EDT
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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realmagick.com The shrine of knowledge.
Irish, Celtic, and general Aryan.
A river Goddess whose name appears across the face of Europe, the tutelary deity of many nations and places (cf. Don River, Danube River, Denmark, etc.). In the isles, she was the Mistress of the Tuatha De Danaan, the race of divine and semi-divine inhabitants of Ireland before the coming of the Milesians.
Suggested Pdf Resources
- Danú Christmas in Ireland: An Nollaig in Éirinn - University of Florida
- University of Florida Performing Arts presents. Danú. Christmas in Ireland: An Nollaig in Éirinn.
- performingarts.ufl.edu
- View Playbill
- Danú. Wednesday, December 10, 2014. The Englert Theatre.
- hancher.uiowa.edu
- View advance program notes here. - Center for the Arts at Virginia
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- Peter Alderson Smith. W. B. Yeats and the Tribes of Danu: Three
- Book Reviews, Volume 32:1, 1988. YEATS AND IRELAND. Peter Alderson Smith .
- muse.jhu.edu
Suggested News Resources
- This Weekend: Danú, 'Dirty Rotten Scoundrels,' etc.
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- St. Patrick's Day, or at least music associated with it, will arrive 18 days early in the Kansas capital when the Topeka Performing Arts Center presents Danu, one of Ireland's leading traditional ensembles, in concert Sunday afternoon.
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- Rusi u jednom danu izveli 150 napada na Palmiru, otvara se put Asadu: 'Džihadisti se od ovog udarca neće oporaviti'. youtube screenshot. Autor: Portal Jutarnji.
Suggested Web Resources
- Danú
- Home page of Danú, a traditional group from Counties Waterford, Kerry, Donegal & Dublin. Hailing from historic Counties Waterford, Kerry, Dublin & Donegal, ...
- www.danu.net
- Danu (Irish goddess) - Wikipedia, the free encyclopedia
- In Irish mythology, Danu ([ˈdanu]; modern Irish Dana [ˈd̪ˠanˠə]) is a hypothetical mother goddess of the Tuatha Dé Danann (Old Irish: "The peoples of the ...
- en.wikipedia.org
- Danú - Wikipedia, the free encyclopedia
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- en.wikipedia.org
- Danú - YouTube
- Apr 26, 2010 Danú performed their traditional Irish music at the Cerritos Center for the Performing Arts on March 3, 2009. Here is one of the songs they ...
- www.youtube.com
- Danú - Facebook
- Danú. 7101 likes · 588 talking about this. Traditional Irish Music Band.
- www.facebook.com
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