text:
Recycling Guide for Woodlands Residents
The Woodlands Recycling and ReUse Facility
Precinct 3
1122 Pruitt Road Map
The Woodlands, TX
This is the main recycling facility for residents of The Woodlands, TX. Help keep The Woodlands green!
Recyclable materials include: Plastic containers, yard trimmings, aluminum cans, cardboard & paperboard, glass containers, metals, paper, automotive fluids and clothing. No household garbage, please.
*Electronics, latex paint, and home improvement by products are for Montgomery County Residents Only.
Phone: 281-367-SAVE (7283)
Recycling Facility Hours:
Monday - Saturday 8:30 am - 4:30 pm
Closed for lunch 11:30 am - 12:30 pm
Except county holidays
Available to Montgomery County Residents. Quick and easy sort!
More information can be found at their web site:
The Woodlands Recycling Center / Research Forest
5310 Research Forest Dr Map
The Woodlands, TX 77381
(next to Bear Branch Park)
Hours are Wednesday from 4pm to 7pm, and Saturday from 9am to 2pm.
Phone: 281-210-3900
Curbside Recycling in The Woodlands
When recycling curbside, please:
What is allowed in the curbside bins?:
Ex. - Newspapers, mail, magazines, office papers
Cardboard / Boxes:
24" boxes or smaller, up to three boxes larger than 24"
Please flatten all boxes and remove non-cardboard
NO wax- or -plastic coated
Glass Bottles:
Green, brown & clear - please rinse.
Aluminum Food / Drink Containers:
Ex. - Soda containers, tin cans. Please crush cans if possible.
No pie pans, aerosol cans or scrap metal.
Plastics #1 - 7:
Check the bottom for the recycling arrow for the plastic #.
Empty contents, rinse, and leave caps on.
Ex. - Juice boxes, milk, soy, soup, broth, wine packages
Refrigerated Cartons:
Ex. - Milk, juice, cream, egg substitutes
Other Recycling Centers in Montgomery County:
Montgomery County Recycling Center -- Precinct 4
23628 Roberts Road
New Caney, Texas
936-521-8919 or 281-577-8919
Hours: Monday - Friday 7:30am - 3:00pm, Except for county holidays
Lonestar Recycling
24523 Gosling Rd
Spring, TX 77389
Hours: Monday - Friday 9:00am - 5:00pm, Closed 12:00pm - 12:30pm for lunch
We accept business electronics - anything with a power cord. No CFL light bulbs accepted. No tube TVs accepted.
Montgomery County Recycling Center -- Conroe Recycling Center -- CLOSED
2501 North FrazierHours: Tuesday - Friday 8:00 am - 5:00 pm, Saturday 8:00 am - 2:00 pm
Conroe, Texas


text: The Top 5 DIY Mistakes Plumbers Are Called To Fix Sometimes a DIY project seems like a good idea when you want to get something around your house fixed or updated and save money. When it comes to making a plumbing repair or installation, however, plenty can go wrong without the right Read More Personal Protective Equipment For Plumbers What Personal Protective Equipment Should a Plumber Own? Every industrial work has its own set of health hazards, whether it is through physical or mental hazards. While the latter has seen several situations where it can be dangerous to the health of Read More Career path as a plumber in the UK What is a plumber? Plumbers offer service and repair of hot and cold water systems, or heating systems in any home and businesses. Also, they work with gas fires and cookers. If you want various job that makes good use of your convenient skills Read More Guest Post by MyWebpal: When to contact a roofing company for your Roof Repair Needs People want to live a stress-free life as much as possible. That is why technology has evolved so much; because people want a life that is easier to live in, faster, accessible and with lesser stressors. It is because of this fast Read More 5 essential tools every plumber should have A plumber uses many tools. Specialized tools include pipe wrenches, flaring pliers, pipe vice, pipe bending machine, pipe cutter, dies and joining tools such as soldering torches and crimp tools. To break down the plumbing tools needed most for DIY plumbing jobs Read More How to Choose the Best Air Compressor for Light Plumbing One of the most common jobs I get called out on is clearing clogged drains. I used to hate those calls, because, let's face it, it's usually a pretty unpleasant job. But not anymore—now, I don't dread the clogged drain calls any Read More Top 5 Reasons you Should be Investing in Property as a Plumber Although real estate markets took a hit in recent years, it's still one of the best investments you can make as a plumber, especially when you think long term. We've put together a list of 5 reasons to invest in property, which Read More Areas Where Plumbers Are (almost) Treated Like Gods There are plenty of choices when choosing a career path to follow – with so many developments in the modern world today, man has been able to create new job descriptions that came right out of their immediate needs. Back in the Read More Tiles in Bathroom Renovations Being among the most frequently used area in the home, it is not uncommon for the typical bathroom to suffer from a number of damages. Some of these can be quite insignificant initially; however, in time, they can become serious enough that Read More Manhole Cleaning Jobs If you have walked down any street, you have probably walked over or near a manhole cover. These covers are the entrance to the sewage systems and tunnels. It is important that these covers remain clean and sanitized. When waste water management Read More How Much Can a Dishwasher Installation Cost You? Best Dishwasher Repair Company in Winnipeg There's a shocking gap between the costs of a quick dishwasher install where you've got everything ready to be swapped, and a totally new dishwasher arrangement. A simple installation into a location where power, water and Read More How Pipe Relining Is Changing The Industry Pipe relining, also known as Cured In Place Pipe (CIPP) was developed in the 70's, and is a trench-less method used to repair already in place pipelines. The method of pipe relining is usually a much faster, and cost effective way of Read More How To Clean Up Your Basement After A Water Main Burst Having problems with a water main burst in your basement? Then you might be looking for answers in how to clean this kind of problem up a right way. There is always a solution to every problem and you just have to find a Read More 12

subset: commoncrawl


text:
Archive for the 'cheminformatics' Category
Which Datasets Lead to Predictive Models?
I came across a recent paper from the Tropsha group that discusses the issue of modelability – that is, can a dataset (represented as a set of computed descriptors and an experimental endpoint) be reliably modeled. Obviously the definition of reliable is key here and the authors focus on a cross-validated classification accuracy as the measure of reliability. Furthermore they focus on binary classification. This leads to a simple definition of modelability – for each data point, identify whether it's nearest neighbor is in the same class as the data point. Then, the ratio of number of observations whose nearest neighbor is in the same activity class to the number observations in that activity class, summed over all classes gives the MODI score. Essentially this is a statement on linear separability within a given representation.
The authors then go show a pretty good correlation between the MODI scores over a number of datasets and their classification accuracy. But this leads to the question – if one has a dataset and associated modeling tools, why compute the MODI? The authors state
we suggest that MODI is a simple characteristic that can be easily computed for any dataset at the onset of any QSAR investigation
I'm not being rigorous here, but I suspect for smaller datasets the time requirements for MODI calculations is pretty similar to building the models themselves and for very large datasets MODI calculations may take longer (due to the requirement of a distance matrix calculation – though this could be alleviated using ANN or LSH). In other words – just build the model!
Another issue is the relation between MODI and SVM classification accuracy. The key feature of SVMs is that they apply the kernel trick to transform the input dataset into a higher dimensional space that (hopefully) allows for better separability. As a result MODI calculated on the input dataset should not necessarily be related to the transformed dataset that is actually operated on by the SVM. In other words a dataset with poor MODI could be well modeled by an SVM using an appropriate kernel.
The paper, by definition, doesn't say anything about what model would be best for a given dataset. Furthermore, it's important to realize that every dataset can be perfectly predicted using a sufficiently complex model. This is also known as an overfit model. The MODI approach to modelability avoids this by considering a cross-validated accuracy measure.
One application of MODI that does come to mind is for feature selection – identify a descriptor subset that leads to a predictive model. This is justified by the observed correlation between the MODI scores and the observed classification rates and would avoid having to test feature subsets with the modeling algorithm itself. An alternative application (as pointed out by the authors) is to identify subsets of the data that exhibit a good MODI score, thus leading to a local QSAR model.
More generally, it would be interesting to extend the concept to regression models. Intuitively, a dataset that is continuous in a given representation should have a better modelability than one that is discontinuous. This is exactly the scenario that can be captured using the activity landscape approach. Sometime back I looked at characterizing the roughness of an activity landscape using SALI and applied it to the feature selection problem – being able to correlate such a measure to predictive accuracy of models built on those datasets could allow one to address modelability (and more specifically, what level of continuity should a landscape present to be modelable) in general.
fingerprint 3.5.2 released
Version 3.5.2 of the fingerprint package has been pushed to CRAN. This update includes a contribution from Abhik Seal that significantly speeds up similarity matrix calculations using the Tanimoto metric.
His patch led to a 10-fold improvement in running time. However his code involved the use of nested for loops in R. This is a well known bottleneck and most idiomatic R code replaces for loops with a member of the sapply/lapply/tapply family. In this case however, it was easier to write a small piece of C code to perform the loops, resulting in a 4- to 6-fold improvement over Abhiks observed running times (see figure summarizing Tanimoto similarity matrix calculation for 1024 bit fingerprints, with 256 bits randomly selected to be 1). As always, the latest code is available on Github.
Updated version of rcdk (3.2.3)
I've pushed updates to the rcdklibs and rcdk packages that support cheminformatics in R using the CDK. The new versions employ the latest CDK master, which as Egon pointed out has significantly fewer bugs, and thanks to Jon, improved performance. New additions to the package include support for the LINGO and Signature fingerprinters (you'll need the latest version of fingerprint).
Support for feature,count fingerprints in fingerprint 3.5.0
I've just updated the fingerprint package to v3.5.0 (should show up on CRAN shortly, or else you can get it directly from my Github repository). The main update in this version is better support for feature,count type fingerprints. An example would be ECFP or signature fingerprints. In these types of fingerprints, the output is usually a set of (integer or long) hash values or else structural fragments along with their count of occurrences.
The updated package now provides an S4 class to represent features and their counts. An example of this class is
f1 <- new("feature",
The package provides getters and setters for these objects, allow you to get or set the feature and the count.
> feature(f1)
> count(f1)
[1] 2
> feature(f1) <- 'ABCD'
> count(f1) <- 12
> f1
Using this class, feature,count fingerprints are now represented as objects of class featvec. For these fingerprints, instead of bits, one obtains a list of feature objects. For fingerprints read from files that provide the hashed version of the underlying structure (or neighborhood etc), the numeric hashes are read in as features, with a default count of 1. The distance method has also been updated to evaluate similarities for feature,count fingerprints, though currently it does not use the count in the similarity calculation.
As an example, consider a set of ECFP's available from here
> fps <- fp.read('http://pastebin.com/raw.php?i=gHjTQNKP', lf=ecfp.lf, binary=FALSE)
> fps[[1]]
Feature fingerprint
name = mol01
source = ecfp.lf
features = 17:1 0:1 16:1 3:1 1:1 1747237384:1 1499521844:1 -1539132615:1 1294255210:1 332760439:1 -1549163031:1 1035613116:1 1618154665:1 590925877:1 1872154524:1 -1143715940:1 203677720:1 -1272768868:1 136120670:1 136597326:1 -1460348762:1 -1262922302:1 -1201618245:1 -402549409:1 -1270820019:1 929601590:1 -1597477966:1 -1274743746:1 -1155471474:1 1258428229:1 -1838187238:1 -798628285:1 -1773728142:1 -773983804:1 -453677277:1 1674451008:1 65948508:1 991735244:1 -1412946825:1 846704869:1 -2103621484:1 -886204842:1 1725648567:1 -353343892:1 -585443181:1 -533273616:1 2031084733:1 -801248129:1 1752802620:1 -976015189:1 -992213424:1 2109043264:1 -790336137:1 630139722:1 -505031736:1 -1427697183:1 -2090462286:1 -1724769936:1
> distance(fps[[1]], fps[[1]])
[1] 1
> distance(fps[[1]], fps[[2]])
[1] 0.1566265
Life and death in a screening campaign
So, how do I enjoy my first day of furlough? Go out for a nice ride. And then read up on some statistics. More specifically, I was browsing the The R Book and came across survival models. Such models are used to characterize time to events, where an event could be death of a patient or failure of a part and so on. In these types of models the dependent variable is the number of time units that pass till the event in question occurs. Usually the goal is to model the time to death (or failure) as a function of some properties of the individuals.
It occurred to me that molecules in a drug development pipeline also face a metaphorical life and death. More specifically, a drug development pipeline consists of a series of assays – primary, primary confirmation, secondary (orthogonal), ADME panel, animal model and so on. Each assay can be thought of as representing a time point in the screening campaign at which a compound could be discarded ("death") or selected ("survived") for further screening. While there are obvious reasons for why some compounds get selected from an assay and others do not (beyond just showing activity), it would be useful if we could quantify how molecular properties affect the number and types of compounds making it to the end of the screening campaign. Do certain scaffolds have a higher propensity of "surviving" till the in vivo assay? How does molecular weight, lipophilicity etc. affect a compounds "survival"? One could go up one level of abstraction and do a meta-analysis of screening campaigns where related assays would be grouped (so assays of type X all represent time point Y), allowing us to ask whether specific assays can be more or less indicative of a compounds survival in a campaign. Survival models allow us to address these questions.
How can we translate the screening pipeline to the domain of survival analysis? Since each assay represents a time point, we can assign a "survival time" to each compound equal to the number of assays it is tested in. Having defined the Y-variable, we must then select the independent variables. Feature selection is a never-ending topic so there's lots of room to play. It is clear however, that descriptors derived from the assays (say ADMET related descriptors) will not be truly independent if those assays are part of the sequence.
Having defined the X and Y variables, how do we go about modeling this type of data? First, we must decide what type of survivorship curve characterizes our data. Such a curve characterizes the proportion of individuals alive at a certain time point. There are three types of survivorship curves: I, II and III corresponding to scenarios where individuals have a higher risk of death at later times, a constant risk of death and individuals have a higher risk of death at earlier times, respectively.
For the case of the a screening campaign, a Type III survivorship curve seems most appropriate. There are other details, but in general, they follow from the type of survivorship curve selected for modeling. I will note that the hazard function is an important choice to be made when using parametric models. There a variety of functions to choose from, but either require that you know the error distribution or else are willing to use trial and error. The alternative is to use a non-parametric approach. The most common approach for this class of models is the Cox proportional hazards model. I won't go into the details of either approach, save to note that using a Cox model does not allow us to make predictions beyond the last time point whereas a parametric model would. For the case at hand, we are not really concerned with going beyond the last timepoint (i.e., the last assay) but are more interested in knowing what factors might affect survival of compounds through the assay sequence. So, a Cox model should be sufficient. The survival package provides the necessary methods in R.
OK – it sounds cute, but has some obvious limitations
- The use of a survival model assumes a linear time line. In many screening campaigns, the individual assays may not follow each other in a linear fashion. So either they must be collapsed into a linear sequence or else some assays should be discarded.
- A number of the steps represent 'subjective selection'. In other words, each time a subset of molecules are selected, there is a degree of subjectivity involved – maybe certain scaffolds are more tractable for med chem than others or some notion of interesting combined with a hunch that it will work out. Essentially chemists will employ heuristics to guide the selection process – and these heuristics may not be fully quantifiable. Thus the choice of independent variables may not capture the nuances of these heuristics. But one could argue that it is possible the model captures the underlying heuristics via proxy variables (i.e., the descriptors) and that examination of those variables might provide some insight into the heuristics being employed.
- Data size will be an issue. As noted, this type of scenario requires the use of a Type III survivorship curve (i.e., most death occurs at earlier times and the death rate decreases with increasing time). However, decrease in death rate is extremely steep – out of 400,000 compounds screened in a primary assay, maybe 2000 will be cherry picked for confirmation and about 50 molecules may be tested in secondary, orthogonal assays. If we go out further to ADMET and in vivo assays, we may have fewer than 10 compounds to work with. At this stage I don't know what effect such a steeply decreasing survivorship curve would have on the model.
The next step is to put together a dataset to see what we can pull out of a survival analysis of a screening campaign.


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Acknowledging Our Recent Graduates:
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realmagick.com The shrine of knowledge.
Basque Country Geography
A selection of articles related to basque country geography.
Original articles from our library related to the Basque Country Geography. See Table of Contents for further available material (downloadable resources) on Basque Country Geography.
- King James Bible: Hebrews, Chapter 11
- Chapter 11 11:1 Now faith is the substance of things hoped for, the evidence of things not seen. 11:2 For by it the elders obtained a good report. 11:3 Through faith we understand that the worlds were framed by the word of God, so that things which are seen...
New Testament >> To the Hebrews
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
- King James Bible: Luke, Chapter 8
- Chapter 8 8:1 And it came to pass afterward, that he went throughout every city and village, preaching and showing the glad tidings of the kingdom of God: and the twelve were with him, 8:2 And certain women, which had been healed of evil spirits and...
New Testament >> Luke
- King James Bible: Mark, Chapter 5
- Chapter 5 5:1 And they came over unto the other side of the sea, into the country of the Gadarenes. 5:2 And when he was come out of the ship, immediately there met him out of the tombs a man with an unclean spirit, 5:3 Who had his dwelling among the tombs;...
New Testament >> Mark
- King James Bible: Mark, Chapter 6
- Chapter 6 6:1 And he went out from thence, and came into his own country; and his disciples follow him. 6:2 And when the sabbath day was come, he began to teach in the synagogue: and many hearing him were astonished, saying, From whence hath this man these...
New Testament >> Mark
- Story of the Celts: Who are the Celts?
- The ancient Celts were a group of culturally similar peoples who once occupied most of central and western Europe, north of the Greco-Roman world. Perhaps the most common cultural characteristic of the ancient Celts were the Celtic languages, a branch of the...
History & Anthropology >> Celtic & Irish
- Everyday Earth
- When you think of "Earth" what comes to mind? Perhaps you feel the stable element of solidity and grounding. Or maybe you see Earth as the third planet from the Sun. Or for you, is Earth the rich brown soil in your own backyard? Earth is all these...
The Elements >> Earth
Basque Country Geography is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Basque Country Geography books and related discussion.
Suggested News Resources
- What we call Kashkaval is Just a Mess
- Come to think of it, the milk distills all sorts of geography, biology and sociology. For the French geographer Jean-Robert Pitté, cheese is a metaphor for the ....
- Ancient Symbols in the New World, Part I
- The students fell in love with the history, geography, and culture of this very unique location, as did I.
- MASS SHOOTING: Female attacker linked to ISIS terrorism
- A U.S. official described the 2014 trip as Farook's "last recorded" trip to the country.
- David Moyes masterclass has fuelled desire to be a boss despite Real Sociedad
- He had to focus on signing players of Basque origin or promoting players from the B team even though they were not ready.
- UNC Football's Fifth-Year Seniors Have Seen It All
- "I graduated from the best university in the country. I'll keep that in my mind. A lot of people don't get this opportunity and [I did].
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Basque Country Geography Topics
Related searchesbertrand russell epistemology
montana important cities and towns
reinforced concrete
list of suspense movies
saffron chemistry
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Affiliations: *From the University of Sydney (Dr. Brieger), Sydney, Australia; the University of Michigan Health System (Dr. Eagle), Ann Arbor, MI; the Canadian Heart Research Centre and Terrence Donnelly Heart Center (Dr. Goodman), Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Hôpital Bichat (Dr. Steg), Paris, France; Grochowski Hospital (Dr. Budaj), Warsaw, Poland; the University of Massachusetts Medical School (Dr. White), Worcester, MA; and Pitié-Salpêtrière Hospital (Dr. Montalescot), Paris, France.,
†A complete list of investigators and institutions can be found in the Appendix.
Correspondence to: David Brieger, MBBS, PhD, Department of Cardiology, Concord Repatriation General Hospital, Hospital Rd, Concord, Sydney, NSW, Australia 2139; e-mail: firstname.lastname@example.com
Study objectives: The clinical manifestations of acute coronary syndromes (ACSs) vary, and patients present frequently with symptoms other than chest pain. In this analysis, a large contemporary database has been accessed to define the frequency, clinical characteristics, and outcomes of patients presenting without chest pain across different diagnostic categories of ACS.
Design and setting: The Global Registry of Acute Coronary Events is a multinational, prospective, observational study involving 14 countries.
Patients: Patients presenting to the hospital with a suspected ACS were stratified according to whether their predominant presenting symptoms included chest pain (ie, typical) or did not (ie, atypical). Demographics, medical history, hospital management, and outcomes were compared.
Measurements and results: Of the 20,881 patients in this analysis, 1,763 (8.4%) presented without chest pain, 23.8% of whom were not initially recognized as having an ACS. They were less likely to receive effective cardiac medications, and experienced greater hospital morbidity and mortality (13% vs 4.3%, respectively; p < 0.0001) than did patients with typical symptoms. After adjusting for potentially confounding variables, increased hospital mortality rates were noted in patients with dominant presenting symptoms of presyncope/syncope (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.4 to 2.9), nausea or vomiting (OR, 1.6; 95% CI, 1.1 to 2.4), and dyspnea (OR, 1.4; 95% CI, 1.1 to 1.9), and in those with painless presentations of unstable angina (OR, 2.2; 95% CI, 1.4 to 3.5) and ST-segment elevation myocardial infarction (OR, 1.7; 95% CI, 1.2 to 2.2).
Conclusion: Patients with ACSs who present without chest pain are frequently misdiagnosed and undertreated. With the exception of diaphoresis, each dominant presenting symptom independently identifies a population that is at increased risk of dying. These patients experience greater morbidity and a higher mortality across the spectrum of ACSs.
Acute coronary syndromes (ACSs) offer a challenge from the standpoint of diagnosis, treatment, and prognosis, as the clinical manifestations vary considerably. The silent or atypical presentation of myocardial infarction is recognized as an important manifestation of coronary heart disease,1–6 with most studies suggesting that it is associated with an unfavorable prognosis.7–8 These unfavorable outcomes may be partly attributable to a failure to use beneficial treatment strategies in these patients.5–6
Relative to myocardial infarction patients with atypical symptoms, very little information is available on atypical presentations in patients with less dramatic presentations of ACS such as unstable angina or non-ST-segment elevation myocardial infarction (NSTEMI).9As these patients comprise 67% of all patients with ACSs,10 it would be valuable to document the frequency of atypical presentations among these patients and to determine whether their hospital-associated outcomes are similarly disappointing.
The Global Registry of Acute Coronary Events (GRACE) is a large, prospective, multinational registry of patients who have been hospitalized with the spectrum of ACSs.10–11 In this analysis, we identified a population of patients presenting without chest pain, and therefore with atypical symptoms of ACSs. The characteristics of these patients, treatment practices, and hospital outcomes are described, and are compared with those of patients presenting with chest pain in a contemporary, real-world setting.
The full details of the GRACE rationale and methodology have been published.10–11 GRACE is designed to reflect an unbiased population of patients with ACSs, irrespective of geographic region. Currently, 95 hospitals located in 14 countries (ie, Argentina, Australia, Austria, Belgium, Brazil, Canada, France, Germany, Italy, New Zealand, Poland, Spain, the United Kingdom, and the United States) are participating in this observational study.
Patients enrolled in the registry had to be at least 18 years old, alive at the time of hospital presentation, admitted for ACS as a presumptive diagnosis (ie, have symptoms consistent with acute ischemia), and have at least one of the following symptoms: ECG changes consistent with ACS; serial increases in serum biochemical markers of cardiac necrosis; and/or documentation of coronary artery disease. The qualifying ACS was not to be precipitated or accompanied by significant comorbidity, trauma, or surgery.
Enrollment in GRACE commenced in April 1999. At hospital admission, patients were assigned a working diagnosis of myocardial infarction, unstable angina, rule-out myocardial infarction, chest pain, and other cardiac or noncardiac conditions. The dominant symptom that had precipitated the presentation was documented, together with other accompanying symptoms. A typical presentation was defined when the reported symptoms included chest pain. If the presentation was not accompanied by chest pain, the patient was regarded as presenting with atypical symptoms. Patients presenting who were in cardiac arrest were not included in this analysis because their poor outcomes have already been well-characterized.12–13 Patients with a hospital discharge diagnosis of noncardiac chest pain or non-ACS presentation also were excluded. All cases were therefore assigned to one of the following categories: ST-segment elevation myocardial infarction (STEMI); NSTEMI; or unstable angina.
Patients received a diagnosis of STEMI when they had new or presumed new ST-segment elevation of ≥ 1 mm seen in any location, a new left bundle branch block on the index, or a qualifying ECG with at least one positive cardiac biochemical marker of necrosis (eg, troponin measurements, whether qualitative or quantitative). In cases of NSTEMI, at least one positive cardiac biochemical marker of necrosis without new ST-segment elevation seen on the index or qualifying ECG had to be present. Unstable angina was diagnosed when the levels of serum biochemical markers that were indicative of myocardial necrosis in the laboratory of each hospital were within the normal range. Patients originally admitted to the hospital because of unstable angina, but in whom myocardial infarction evolved during the hospital stay, were classified as having a myocardial infarction.
Data were collected at each site by a trained coordinator using a standardized case report form to collect information on demographic characteristics, medical history, presenting symptoms, time of presentation, duration of prehospital delay, biochemical and ECG findings, treatment practices, and a variety of hospital outcome data. Standardized definitions of all patient-related variables and clinical diagnoses were used.11
Differences in patient demographics, clinical characteristics, and hospital management and outcomes between patients presenting with atypical and typical symptoms were assessed using the χ2 test or the Fisher exact test for categoric variables (expressed as frequencies and percentages), and the Wilcoxon rank sum test for continuous variables (expressed as medians and interquartile range). Multiple logistic regression was used to examine the association between atypical and typical presentations of acute coronary disease and the hospital case fatality rate, adjusting for factors associated with p < 0.25 on univariate analysis. These included the following: age; sex; diabetes; history of hyperlipidemia, hypertension, smoking, congestive heart failure, and percutaneous coronary intervention; type of ACS; systolic BP; diastolic BP; pulse; initial creatinine level; and Killip class. Hospital mortality among patients in these two groups according to type of ACS (ie, STEMI, NSTEMI, and unstable angina) was explored through the addition of interaction terms in our regression models. In addition, multivariate analysis was used to determine the significance of each of the four major characteristics of atypical presentation (ie, dyspnea, diaphoresis, nausea/vomiting, or syncope/presyncope) for hospital survival in relation to patients presenting with chest pain.
Over the period July 1999 to June 2002, 20,881 patients were admitted to the hospital with ACSs, of whom 1,763 (8.4%) presented with atypical symptoms. The dominant presenting symptoms in these patients were dyspnea in 869 (49.3%), diaphoresis in 462 (26.2%), nausea or vomiting in 426 (24.3%), and presyncope/syncope in 335 (19.1%) [Fig 1]
Patients without chest pain were significantly older than those with typical symptoms. They were more likely to be women and to have a history of hypertension, diabetes, or heart failure, but they were less likely to have a history of smoking, hyperlipidemia, or percutaneous coronary intervention (Table 1
). Patients with atypical symptoms took longer to present to the hospital than did those with typical symptoms (3.2 vs 2.9 h, respectively; p < 0.02) and were more likely to have signs of heart failure on presentation (Killip class II-IV, 41.8% vs 16.1%, respectively; p < 0.001). The nature of the presenting symptom (ie, typical vs atypical) did not influence the likelihood of there being ischemic changes on the presenting or index ECG.
Frequently, atypical symptoms were not recognized as being caused by coronary ischemia. On presentation, 23.8% of patients were given incorrect diagnoses with other cardiac or noncardiac conditions, compared with 2.4% of those with typical presentations (Fig 2
After hospital presentation, there were differences in the medical and interventional treatments provided to patients. Patients with STEMI were less likely to receive either fibrinolysis or primary percutaneous coronary intervention if their symptoms were atypical. This group was also less likely to receive treatment with β-blockers, a difference that was apparent within the first 24 h of presentation and persisted throughout their hospital stay. Similarly, the use of aspirin was lower in patients with atypical presentations, both within the first 24 h of presentation and throughout their hospital stay. The use of angiotensin-converting enzyme (ACE) inhibitors was comparable between the two groups during hospital admission, and, at the time of discharge from hospital, patients who had presented without chest pain were more likely to be receiving an ACE inhibitor. However, they were less likely to be receiving treatment with a β-blocker, aspirin, or a statin at hospital discharge (Table 2
Patients with NSTEMI or unstable angina who presented with atypical symptoms were less likely to undergo coronary angiography and percutaneous coronary intervention during their hospital stay. They were also less likely to receive anticoagulant or antiplatelet treatment within 24 h of presentation. After this time, there was a decline in the use of these treatments in both groups. The prescription of β-blockers was less frequent in patients with atypical presentations, both within the first 24 h and subsequently. Similar to STEMI patients, these patients were less likely to receive therapy with aspirin, a β-blocker, or a statin at hospital discharge (Table 3
The hospital complications of heart failure, cardiogenic shock, arrhythmias, and renal failure were seen more commonly in patients with atypical presentations (Table 4
). In addition, their hospital case fatality rates were increased, with 13.0% of atypical patients dying compared with 4.3% of typical patients (p < 0.001). This excess mortality rate remained after correction for other factors known to contribute to an unfavorable outcome (adjusted odds ratio [OR], 1.6; 95% confidence interval [CI], 1.3 to 1.9).
When hospital death rates were analyzed according to the type of ACS, almost 20% of patients with atypical symptoms of STEMI died in hospital (atypical symptoms, 18.7%; typical symptoms, 6.3%; p < 0.001). Those patients presenting with anterior STEMI had the highest mortality rate of any group (23.4% vs 7.4%, respectively; p < 0.001), but an atypical presentation also heralded a poor outcome for those with inferior or lateral STEMI (15.4% vs 5.4%, respectively; p < 0.001). Regardless of the type of ACS, atypical presentation was associated with an increased risk of hospital death compared with typical presentation (NSTEMI, 11.9% vs 4.2%, respectively; unstable angina, 8.0% vs 2.5%, respectively; p < 0.001 for both) [Fig 3]
. This risk was attenuated after correction for other factors associated with a higher mortality rate but remained significant for patients with STEMI (adjusted OR, 1.7; 95% CI, 1.2 to 2.2) and unstable angina (adjusted OR, 2.2; 95% CI, 1.4 to 3.5).
The adverse outcomes among patients without chest pain could not be predicted by the dominant symptom that had accompanied their presentation. When patients were grouped according to these symptoms and compared with the population presenting with chest pain, a greater risk of dying was found for all patients except those presenting predominantly with diaphoresis (Fig 4
Although presentations with ACSs share common underlying pathophysiologic mechanisms, they offer a challenge from the standpoint of diagnosis, treatment, and prognosis because the clinical manifestations of these conditions vary considerably. Most episodes of ACSs are characterized predominantly by chest pain. However, a proportion of patients may have atypical, minimal, or no symptoms.
In our population, patients with atypical symptoms were more likely to be older, female, hypertensive, and diabetic, and to have a history of heart failure. Previous studies14–21 of patients with myocardial infarction have described similar characteristics among patients presenting without chest pain or with atypical symptoms. As the population continues to age, with women outliving men, it is likely that patients without chest pain will make up an increasing proportion of those presenting with an ACS.
The propensity for patients with diabetes to present with atypical or absent symptoms has been well-recognized22–23 and is believed to be a manifestation of their tendency to autonomic neuropathy, with a consequent defective anginal warning system.24 It is notable, however, that in our cohort diabetes was noted in < 33% of the population with atypical symptoms, indicating that the problem extends to a much wider group of patients.
Approximately 25% of our patients were not recognized as having an ACS on presentation. This delay in the recognition of the diagnosis is particularly important for patients with STEMI, for whom early therapy is imperative.25We previously reported26 that patients with STEMI are significantly less likely to receive reperfusion therapy. This current analysis indicates that, throughout the course of their hospital admission, these patients are less likely to receive treatment with β-blockers, antiplatelet therapy, or statin therapy. Interestingly, they are more likely to be discharged from the hospital while receiving an ACE inhibitor than are patients with chest pain, suggesting that the greater prevalence of heart failure in this population is recognized, but the importance of secondary prevention against further coronary events is not.
In contrast to the significant body of literature describing atypical or unrecognized myocardial infarction, less attention has been paid to the frequency or significance of the atypical presentation of ACSs in patients either meeting the newer, more inclusive definitions of myocardial infarction (ie, elevated troponin levels) or not having myocardial necrosis (ie, unstable angina). In a retrospective medical chart review9 of 4,167 Medicare patients who had been hospitalized with unstable angina in 22 Alabama hospitals, atypical presentations were identified in > 50% of the population. However, unlike the diagnostic criteria adopted in GRACE, those for unstable angina in this study could be made in the absence of objective evidence of coronary disease. As symptoms are such an important component of the diagnosis, it is possible that many of these patients did not have an ACS. Consistent with this, the hospital mortality rate was very low in this elderly population (0.9%) and was not significantly different from that in patients who presented with chest pain (0.6%; p = 0.4).9
Of the patients with unstable angina and NSTEMI in our analysis, 5.7% and 12.3%, respectively, presented with atypical symptoms. Coronary angiography and subsequent treatment with revascularization, anticoagulant therapy, antiplatelet therapy, and β-blocker therapy were used less frequently in patients with atypical symptoms than in those with chest pain. When discharged from hospital, these patients were less likely to be receiving aspirin, β-blockers, or statins than were those presenting with chest pain. The reduced administration of these therapies early after hospital admission was presumably contributed to by the failure to recognize the diagnosis on presentation. However, it is clear from our data that these omissions in therapy were not adequately corrected during hospital admission and presumably contributed to the poorer outcomes of those patients.
Given the greater baseline risk of the population presenting without chest pain, it is not surprising that they were more likely to experience complications during their hospital stay. Nonetheless, the excess mortality rate observed in this cohort was striking. As in patients with chest pain, there was a clear gradation of risk that was determined by the severity of the manifestation of the ACS, with almost 20% of STEMI patients presenting without chest pain dying in the hospital. However, the absence of chest pain predicted a greater likelihood of in-hospital death across the spectrum of ACSs, and, even after multivariate analysis, the excess mortality rate persisted among patients with unstable angina and STEMI. We had anticipated that a presenting characteristic, such as the nature of the dominant symptom, might have served as a distinctive predictor of mortality among patients presenting without chest pain. However, with the exception of diaphoresis, each of the dominant presenting symptoms independently identified a population that was at increased risk of dying. Therefore, from a prognostic point of view, the most important feature to identify was the absence of chest pain in these patients.
GRACE is the largest multinational registry study to include the complete spectrum of ACS patients. In addition, this registry employs standardized criteria for defining ACS and hospital outcomes, and the most rigorous quality control and audit measures of any current or previously published registry data sets.
A limitation that can apply to registries of this nature is that the information provided is often extracted from the medical record, requiring second-hand interpretation by the study coordinator or physician. However, the nature of a principal presenting symptom, which provided the basis of this analysis, is almost invariably well-documented in the medical record and was therefore unlikely to be subject to misinterpretation.
This analysis has shown that patients with acute coronary ischemia in the absence of chest pain are older and sicker than those with chest pain. The diagnosis is often made belatedly, and initial and subsequent hospital management is suboptimal. With the exception of diaphoresis, each dominant presenting symptom independently identifies a population that is at increased risk of dying. These patients represent a high-risk group, independent of whether their presentation is accompanied by myocardial infarction. Emergency department and coronary care personnel need to have an increased awareness of this patient cohort, who should be provided with improved early diagnosis and better treatment options to reduce their significant morbidity and mortality.
Keith A. Fox, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK; and Joel M. Gore, University of Massachusetts Medical School, Worcester, MA.
Kim A. Eagle, University Hospital, Ann Arbor, MI; and P. Gabriel Steg, Hôpital Bichat, Paris, France.
Giancarlo Agnelli, University of Perugia, Perugia, Italy; Frederick A. Anderson Jr, University of Massachusetts Medical School, Worcester, MA; Álvaro Avezum, CTI-A Hospital Albert Einstein, São Paulo, Brazil; David Brieger, Concord Hospital, Sydney, NSW, Australia; Andrzej Budaj, Grochowski Hospital, Warsaw, Poland; Marcus D. Flather, Royal Brompton & Harefield NHS Trust, London, UK; Robert J. Goldberg, University of Massachusetts Medical School, Worcester, MA; Shaun G. Goodman, St Michael's Hospital, Toronto, ON, Canada; Christopher B. Granger, Duke University Medical Center, Durham, NC; Dietrich C. Gulba, Cardiology Krankenhaus Düren, Medizinische Klinik Düren, Düren, Germany; Enrique Gurfinkel, Buenos Aires University, Buenos Aires, Argentina; Brian M. Kennelly, Hoag Memorial Hospital Presbyterian, Newport Beach, CA; Werner Klein, Medizinische Universitätsklinik, Graz, Austria; José López-Sendón, Hospital Universitario Gregorio Marañon, Madrid, Spain; Gilles Montalescot, Pitié-Salpétrière Hospital, Paris, France; and Frans Van de Werf, University of Leuven, Leuven, Belgium.
Abbreviations: ACE = angiotensin-converting enzyme; ACS = acute coronary syndrome; CI = confidence interval; GRACE = Global Registry of Acute Coronary Events; NSTEMI = non-ST-segment elevation myocardial infarction; OR = odds ratio; STEMI = ST-segment elevation myocardial infarction.
GRACE is supported by an unrestricted educational grant from Aventis Pharma, Bridgewater, NJ.
Values given as median (interquartile range) or No. (%) unless otherwise indicated. CABG = coronary artery bypass grafting; PCI = percutaneous coronary intervention; NS = not significant.
Values given as No. (%), unless otherwise indicated. See Table 1 for abbreviations not used in the text.
Numbers in parentheses are based on patients alive at least 24 h after hospital admission.
Numbers in parentheses are based on percentages of patients surviving to hospital discharge.
Values given as No. (%), unless otherwise indicated. LMWH = low-molecular-weight heparin. See Table 1 for abbreviations not used in the text.
Numbers in parentheses are based on patients surviving to hospital discharge.
Values given as No. (%), unless otherwise indicated. CHF = congestive heart failure; VF = ventricular fibrillation; VT = ventricular tachycardia.
The authors of this report would like to express their gratitude to the physicians and nurses participating in GRACE. Further information about GRACE, along with a complete list of participants, is available at www.outcomes.org/grace.
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Max Irons
Born Oct 17, 1985
- Actor, Model
Net Worth
Under Review
Do you know the net worth?
Maximilian Paul Diarmuid "Max" Irons is an English film actor and model. He is perhaps most noted for his roles in Red Riding Hood, The White Queen and, most recently, in The Host.
Max Irons Stats
Nickname: Maximilian Paul Diarmuid Irons, Maximilian Paul Irons, Maximilian Paul Diarmuid "Max" Irons, Max
Profession: Actor, Model
Height: 6 ft 2 in (1.88 m)
Nationality: United Kingdom
Date of Birth: Oct 17, 1985 (31 years old)
Place of Birth: London Borough of Camden
Max Irons Film Roles
Red Riding HoodHenry
The HostJared Howe
Dorian GrayLucius


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The proposed conference will be held at Surya University, Indonesia which aims to enable researchers build connections between different digital applications.
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Get out and stay out.
When a single day in the mountains isn't enough wilderness time to help restore your sanity, load up the Osprey Women's Kyte 36 Backpack with everything you need for an overnight's worth of exploration and relaxation. Throw your sleeping bag in the special bottom compartment, then pack your food, fuel, and extra layers in the top-loading main compartment for quick and easy access when you need to change or set up camp. The top lid is large enough to carry thetopo maps and snacks you need when you're on the trail, while the two side hip belt pockets are good spots to keep a tube of sunscreen and headlamp when your chosen route requires early morning starts and miles down long, winding trails through sunny meadows. If sunny skies turn dark and cloudy, you'll be ready to keep your gear dry with the integrated rain cover, which flips up and over the Kyte in a jiffy so sudden cloudbursts don't leave your tent, sleeping bag, and warm clothes soggy.
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Kyte in the British Columbia backcountry
A fun day tour in the backcountry near Fernie, BC. The Kyte 36 is the perfect size for all of my day touring needs.
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hot milf! ^^
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Nice sex!!!


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Reviewed By meghan g (Easton, PA) Reviewed for a 2012 Honda Odyssey —10/18/2016 9:49 AM
This went into my wifes Odyssey and no big improvements but i got a lifelong filter at a great price!
Reviewed By mark d (Pottstown, PA) Reviewed for a 2011 Ford F-150 —9/30/2016 2:04 AM
Goes one easy- fits nice and looks good- seems like the water repellent works, had the hood open while raining out and water beaded off of it. It is alittle overpriced tho or a small thing of material.


text:
Each winter, college football's coaching carousel spins with furious abandon, seemingly faster with each passing year.
The dominoes fall from the highest level to college football's lowest rung, affecting everyone from power-five programs to the sacrificial lambs who march into power-five stadiums for a huge paycheck on autumn Saturdays.
A recent ESPN.com article estimated that 103 college football coaches were affected by Mack Brown's resignation at Texas alone, from Louisville coach Charlie Strong on down.
We focus on the head coaches who shuffle, but the coordinators who change zip codes are equally important. Last winter, over 50 FBS coordinators changed jobs, whether they were following their boss to a new job, chasing a bigger paycheck or simply taking a job, period.
And some jobs are easier than others. Here are five coordinators who face potentially difficult transitions this fall.


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Ronnie Estay took a path less traveled for a football player of his caliber after his 1971 All-American season at LSU.
Estay, known as "Crockett" in his native Larose, should've terrorized NFL quarterbacks as a defensive lineman with his 6-foot-1, 240-pound frame and cat-like quickness for a decade earning honors and ending with a Hall of Fame induction. But, Estay didn't choose to play in the NFL after the Denver Broncos took him in the eighth round of the 1972 draft.
The British Columbia Lions of the Canadian Football League drafted him that same year. His decision between the two leagues was easy, as the CFL offered him something the NFL did not.
"I got as much money in Canada as I would've in the NFL. But the Canadian League had guaranteed contracts, so that was hard to pass up," Estay said.
So, instead of chasing NFL quarterbacks, Estay made life miserable for CFL signal callers from 1972-82.
After playing one and a half seasons with the Lions, he was traded to the Edmonton Eskimos during the 1973 season.
With Edmonton, Estay flourished as the Eskimos played in nine Grey Cup games (the CFL's equivalent of the Super Bowl), winning six titles including an amazing five in a row from 1978-82.
Estay captained several of Edmonton's championship teams and was selected all-CFL twice and was a Western Conference all-star four times. Twice he was the runner-up for the Schenley Award for the Defensive Lineman of the Year. He won the Mack Tuck Award for Western Defensive Lineman of the Year in 1977 and was inducted into the LSU Hall of Fame in 1998 and the Alberta (Province) Sports Hall of Fame in 2000.
His career achievements earned him an induction into the CFL Hall of Fame in 2003, and today Estay, the defensive line coach for the Saskatchewan Roughriders, still holds the single-game sack record in the CFL with five.
"Whenever you are picked by your peers, no matter what the profession you're in, as one of the best, it is the top of the mountain," Estay said. "We were just a bunch of guys (the Edmonton championship teams) who loved the game of football and did what it took to win. It made no difference what the score was until the end of the game. We kept fighting and we won some games with no time left on the clock."
Before he graced the frozen fields of the CFL, Estay's football career began on the bayou playing for South Lafourche High School in 1966-67.
It was just before the start of his high school career that tragedy struck his family. Estay's older brother, Maxie, was a freshman football player at LSU when he was killed in a car accident in 1964.
It was at that point that Estay made a commitment to fill his brother's shoes. Little did he know that he would become a CFL Legend.
"My dad was real proud of him (Maxie) and he took it (his death) real hard," Estay said. "I was in ninth grade and I just made a decision at that time to be best football I could be. But I never dreamed my career would end up in the way it did."
Estay enrolled at LSU in 1968, but his Tiger football career started in 1969. He was part of the defense that yielded 38 yards rushing per game (still an SEC record) as the Tigers finished with a 9-1 record that season.
In the 1970-71 seasons, Estay cemented his name in Tiger lore in the two monumental battles against Notre Dame. The Fighting Irish defeated the Tigers 3-0 in 1970, but LSU avenged that loss in 1971 with a 28-8 victory.
Estay said looking at the way the college game was played then clearly acknowledges how great LSU's defensive teams were during that era.
"At the time, everybody was running the wishbone and Ole Miss, with Archie Manning, was the only team throwing the ball," Estay said. "We were the first team ever to hold Notre Dame scoreless until the fourth quarter, and we did it twice. They beat us in 1970, but some guy on ABC (television) said that if Notre Dame is No. 1, then LSU is 1-A.
"The next year, they came to Death Valley and we had three goalline stands. That was the game that I was the ABC-TV Player of the Game and I became ABC's Defensive Player of the Year."
Estay started to become a national figure in 1970 when he sacked Auburn quarterback Pat Sullivan, a future Heisman Trophy winner, and Manning for safeties that season. Along with his great play on the field, Estay was also an All-Academic SEC choice in 1970 and became a team captain in 1971.
Thibodaux native Joe Fakier, a teammate at LSU, said Estay did more than just play great football. He became sort of a big brother to the younger Fakier.
"He was our captain, so that says a lot of what the team thought of him," Fakier said. "He and Art Cantrelle were juniors, when I got there and they were like big brothers to me because I was from the bayou. There weren't too many of us and we spoke a language no one else could understand.
"He was one of the best (lineman) in the nation and a great person willing to help you in anyway he could."
After his career at LSU, Estay set his sights on a professional career.
Estay said he was with New Orleans Saints wide receiver Danny Abramowicz when LSU coach Charlie McClendon called to tell him the Broncos chose him.
But when the B.C. Lions chose him, Estay said he decided to take his game north.
"The Saints wanted to take me in the 13th round, but Coach Mac said Denver picked me. I said, �If they want me then I'm going to go," Estay said. "I didn't know anything about the Canadian League: then they (B.C.) picked me too. My quickness and speed was the thing. I still hold the record here with five sacks in one game."
Estay wasn't the only big name college football player in the CFL at the time. Former Washington Redskins quarterback Joe Theisman and former St. Louis Cardinals running back Terry Metcalf both played in the CFL.
"A lot of players went back and forth (between the NFL and CFL)," Estay said. "There were a lot of CFL players that couldn't play in the NFL. But there were a lot of NFL players that couldn't play here because of the length and width of the field and the speed."
In a CFL career filled with excellence and achievements, one game stands out to Estay.
"The greatest pro game I played in was in 1981. In 1980, we had won three (Grey Cups) in a row and we were playing to make history," Estay said. "If we won that one we would be the first professional football team to win four (championships) in a row. At halftime, we were losing 20-1, but we came back to win 26-23."
The Eskimos rallied against Ottawa to win its fourth straight Grey Cup. After a 3-5 start to the 1982 season, Edmonton won eight straight games and defeated Toronto 32-16 for a fifth consecutive title.
As Estay was winning championships and honors in Canada, his fans in Louisiana knew little of his achievements.
"Back then, the media wasn't this explosion as it is now," Fakier said. "The only time we heard about him in Canada was when he wrote letters and they pinned it on the bulletin board and we read them. I don't think he got his just (do), but he is in the hall of fame."
Estay retired after the 1982 season but was summoned by his former Eskimo coach Ray Jauch to play for the Washington Federals of the United States Football League.
Estay was with the Federals in the 1983 season, but officially called it quits in 1984. However, in 1983 he played against another former SL athlete, Bobby Hebert, who quarterbacked the Michigan Panthers to the inaugural USFL championship that season.
"That was amazing. When I was at LSU and he was in the first grade, he sent me a letter that I was his idol," Estay said. "Then in 1983 I played against him and I had him four times for a sack, but he threw the ball away before I got to him."
Estay got into the coaching ranks in 1984 and had stints in Louisiana at Christian Life Academy and Jackson High School. He also had two stints as an assistant coach at Evangel University (NAIA) of Springfield, Mo., from 1984-88, then again in 1993-99. He also coached at Liberty University.
It was during his second stint with Evangel that Estay was a candidate to replace Nicholls State coach Darren Barbier.
"I talked to (Dr. Donald Ayo) and he told me to come on down for an interview, so I went," Estay said. "It was good, but I don't know if they didn't like my offensive and defensive philosophy I had.
"But if they would have offered it to me, I would have taken it."
Currently, Estay is the defensive line coach for the Saskatchewan Roughriders. He has been in that position since the 2000 season.
Saskatchewan opens the 2005 season Saturday against he Winnipeg Blue Bombers.
Estay said he is looking into the possibilities of getting into the Louisiana High School Hall of Fame, which would open the door for him to be inducted into the College Football Hall of Fame.
Whether that happens or not, Estay said he is proud of his accomplishments and his only regret is having a decorated professional career that went unnoticed by American football fans.
"(I'm disappointed) for the people who supported me at LSU and South Louisiana," Estay said. "I always loved to entertain the people. I did that (entertain) so great in Canada that I wish the people in South Louisiana could have seen it and gone through the things I went through.
"I just want to thank the people from Louisiana for all the support they have given me," Estay said fighting back emotions.


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Earlier this week, Doug Whaley wrapped up his first combine since being named the Buffalo Bills' general manager last May.
But what about former GM Buddy Nix, who stepped down from his role to become a special assistant? Nix was spotted on occasion at the Bills' facility last season and also was at the Senior Bowl last month, but he did not make the trip to Indianapolis.
"A man flies 250,000 miles a year for 10 to 12 years, that's enough," Nix told Mark Wiedmer of the Chattanooga Times Free Press this week.
Nix is still actively scouting for Buffalo, but at 74 limits his trips to those within driving distance.
"I'm going to six or seven pro days around the Southeast the next week or so. I'll be in Auburn on Tuesday. I'll also go to Alabama, Georgia, Georgia Tech and either Tennessee or South Carolina, since they're scheduled for the same day," Nix told the newspaper. "I'm just not planning on going anywhere I can't drive."
The Bills went 16-32 in Nix's three seasons as general manager, which was followed by a 6-10 record in Whaley's first season. The team likes to talk about being in "rebuilding" mode, but even Nix acknowledged that there is a shelf life for that term.
"We wanted to build around defense," Nix said. "And we have. But you don't get much time these days. With most teams, if the coach isn't winning by his third year, he might be gone."
Nix also provided some insight into a pair of prospects in the 2014 draft: Missouri defensive end Michael Sam and Auburn defensive end Dee Ford.
"There's a possibility [Sam] won't [make an NFL roster]," Nix said. "But it won't have anything to do with his sexual preference. There have been gay players in NFL locker rooms for more than 40 years. I know it wouldn't be a problem in our locker room in Buffalo. The problem for Sam is where do you play him? He might make it as a situational pass-rusher. We have one of those in Buffalo with Jerry Hughes. But there's no way he'd beat out Jerry Hughes."
Conversely, Nix seems high on Ford, who could be a first-round pick in May.
"He's such a tenacious player," Nix said. "Great dedication, great motor. I can't wait to get down there and see him."


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As the world remembers the tragedy that struck the Twin Towers in New York City eleven years ago today, the National Religious Broadcasters (NRB) Network has launched a special 9/11 program and a new series that seek to renew Christians' faith in Christ and educate them on the importance of love for their Muslim neighbors.
The first program, "A Wake Up Call for God's People," is a two-hour special airing Tuesday, Sept. 11 at 8 p.m. and midnight ET and hosted by evangelist Anne Graham Lotz, the daughter of famed preacher Billy Graham.
According to a press release by the NRB Network, in this special program Lotz will speak on the importance of Christians "waking up" to God's word after the 9/11 tragedy, which took the lives of 3,000 innocent victims. more >>
Dr. Scott Ferguson, assistant professor in the Department of Humanities & Cultural Studies at the University of South Florida, recently joined other colleges around the nation in trying to ban Chick-fil-A from campus. Ferguson has launched an online petition to kick the chicken fast food service out of the school's Marshall Student Center.
By now most of us know that the unpardonable "offense" committed by Chick-fil-A's president, a Christian, was his unabashed support for traditional marriage and his opposition to efforts to redefine the institution. But equally significant is the fact that Dr. Ferguson is using an Internet-based site, change.org, to create his online petition – in effect, using the web as a handy tool to punish a national restaurant chain because its president exercised his First Amendment rights. The Internet, long heralded as the new bastion of openness and freedom of information, also can be used, it seems, as an effective way to shove disfavored or "politically incorrect" ideas outside the city gates.
Another back-story on this Chick-fil-A controversy is equally intriguing and also leads to the same point. When Gov. Mike Huckabee posted his support for Chick-fil-A on his Facebook page and called on people to participate in an "appreciation day" for the food company, Facebook took down his announcement for a full 12 hours. Only after a public outcry was it restored. Facebook has indicated for some time its support for LGBT issues, and for that reason, its "takedown" of Gov. Huckabee's exercise of free speech, while deeply troubling, was not surprising. But wait! Wasn't Mark Zuckerberg, the founder of Facebook, the same person who said at last year's G-8 conference that open and free communications over the Internet should be credited with the so-called "Arab Spring" in the Middle East? Mr. Zuckerberg, as well as Google's former CEO Eric Schmidt, and Apple's innovative genius, the late Steve Jobs, have all praised, at various times, the concept of expressive "openness" on Internet platforms. more >>
Dr. Frank Wright, President & CEO of National Religious Broadcasters (NRB), has been awarded with the prestigious Champion of Religious Freedom Award by the Unity Coalition for Israel (UCI) at a recent press conference in Nashville.
The UCI, an alliance of Christian and Jewish organizations actively working together to generate support for the State of Israel, presented Dr. Wright with the award for "courageous leadership in protecting religious freedom world-wide – for such a time as this," NRB revealed.
One of the religious liberty efforts Dr. Wright has been involved in includes re-affirming NRB's commitment to international religious liberty by approving a resolution on the international persecution of Christians, which calls on the U.S. government to strengthen its position globally and to promote the spread of First Amendment freedoms around the world. more >>
NASHVILLE – The bad economy should not stop evangelical Christians from sharing the Gospel and also humanitarian aid in nations with high Christian persecution, Pastor Michael Youssef, founder and president of Leading The Way ministries, said in a speech earlier this week.
Despite having "problems at home," evangelical Christians should not ignore the need for missionary work and they should sacrifice resources even at a time of recession, which is not the case currently, Youssef said at the National Religious Broadcasters convention.
Besides being the founding pastor of The Church of The Apostles in Atlanta, Ga., Youssef is also a media personality with his weekly television and daily radio programs broadcasted in 20 languages and reaching into more than 200 countries. more >>
Susan Molinari, a former rising star in the Republican-led House during the 1990s, has been hired to head Google's Washington operations.
Some pundits see the choice as a smart move in hiring a moderate Republican and someone who most Democrats will not object to. Molinari, the new vice president of public policy and government relations for the Americas, will oversee all aspects of government relations and policy throughout North and South America for Google.
"The Google office in Washington has not had someone with the visibility of a former member of Congress, and with her understanding of the complexities of the legislative process," said former Sen. John Sununu in an interview with Politico. "Google is receiving a higher level of scrutiny…when you're such a large and growing company, you have to have a strong, visible, capable leader in Washington. more >>
NASHVILLE – Popular pastor and international best-selling author Max Lucado gave a sermon at the National Religious Broadcasters convention earlier this week, sharing his view on the nature of God's grace, which is also the subject of his upcoming book, GRACE: More Than We Deserve, Greater Than We Imagine.
Lucado offered a fresh interpretation of the biblical story about the adulteress whom the people of Jerusalem wanted to stone. When the angry mob dragged the woman in front of Jesus, he said: "He that is without sin among you, let him first cast a stone at her" (John 8:7). But Lucado focused on the episode that follows, which, he suggested, reflects grace in a heart-gripping way. As the crowd dispersed, Jesus asked the woman: "Where are your accusers?" This question, Lucado said, can be applied to every Christian, every day.
"Any voices of accusation wake you up this morning?" he asked a hushed room at the Gaylord Opryland convention center. "Any voices of condemnation? You're not good enough? Strong enough? Able enough? Faithful enough? You're not good looking enough?" more >>


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The Gavathiotis laboratory aims to elucidate and target mechanisms of protein-protein interaction in cell death and cell surivival that are deregulated in cancer and other diseases. Our goal is to translate our understanding of biological processes into novel pharmacologic strategies and prototype therapeutics that can lead to cures. To achieve our goal, we take an interdisciplinary approach using chemical synthesis, structure-based design, structural biology, biochemistry, cellular and in vivo pharmacology.
Onyi's work on synthetic antibodies that inhibit BAX through binding to the N-terminal activation site is publisheed in the Journal Of Biological Chemistry!
Dr. Gavathiotis' work is feutured in Albert Einstein' Cancer Center newsletter on cancer stem cell research.
Dr. Gavathiotis and Dr. Kitsis Receive the 2015 AHA Collaborative Sciences Award on developing a novel drug to limit heart damage during myocardial infarction (heart attack) Press release
Dr. Gavathiotis will facilitate a Leducq Transatlantic Network of Excellence with colleagues from Einstein, Rutgers New Jersey Medical School, Howard Hughes Medical Institute/University of Texas Southwestern, Kings College (London, UK), Gustave Roussy (France), University of Padua (Italy), and Maastricht University (Netherlands) for developing novel modulators of autophagy. Press release
Evripidis Gavathiotis, Ph.D wins a 2015 Pershing Square Sohn Prize for Young Investigators in Cancer Research.Press release by PSSCRA Dr. Gavathiotis' 2015 prize winner's page
Tom identified a new binding site on BAX that controls BAX inhibition from
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Dr. Gavathiotis was awarded the 2014 Young Chemical Biologist Award and gave a podium presentation during the Rising Stars of Chemical Biology Session in the 3rd Annual Conference of the International Chemical Biology Society
Two papers in the European Journal of Medicinal Chemistry and Marine Drugs report our collaborative efforts to identify Mcl-1 selective inhibitors and dual Mcl-1/Bcl-xL inhibitors based on the marinopyrole scaffold.


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"Charlton Warren will be an excellent addition to our coaching staff," Nebraska head coach Bo Pelini said in a statement. "He is well respected in the coaching profession and he has been a part of several successful defenses at Air Force. Charlton has great energy and will be an outstanding teacher and mentor for our defensive backs. We look forward to him hitting the ground running, both in working with the young men in our program and on the recruiting trail."
Nebraska needed to fill the position after the departure of Terry Joseph, who took the same position at Texas A&M. The past two seasons Nebraska's secondary has ranked among the best in the Big Ten and the NCAA in passing defense.
"Joining the Nebraska program is a tremendous opportunity for my family and me, and we are extremely excited to be here," Warren said. "I want to thank all the great folks at Air Force who have helped me over the past nine seasons especially Coach Troy Calhoun.
Joseph was known as a coach who could recruit in SEC country, but Warren also has experience in the South, especially in the Georgia area. He also served as a recruiting coordinator at Air Force for three seasons.
"Nebraska football has a rich tradition and history and I can't wait to have a chance to lead and work with the current group of players on this team," said Warren. "I am also big-time excited to hit the recruiting trail and start closing in and meeting the future players who want to join this program and do tremendous things in Lincoln. I appreciate the opportunity, and the faith Coach Pelini and his staff have shown by adding me to the staff and now it's time to get to work."
The hiring announcement should not come as a surprise to Nebraska fans. The Husker coaching staff will host four official visitors this weekend, including two defensive backs. A secondary coach was needed as quickly as possible as Nebraska tries to fill out the 2014 recruiting class.
Three seasons ago, Air Force ranked third in passing yards allowed at 166.9 per game and six in pass efficiency defense. In 2010, much the same, second nationally in passing yards per game (147.8).
Warren will inherit two returning starters in the Nebraska secondary: cornerback Josh Mitchell and safety Corey Cooper. The position is one of the more interesting to watch during spring, as the Huskers look to fill a starting safety spot, cornerback, and nickel.
Big Red Report will have more on the hiring of Warren later today.
*** Information from the Nebraska press release was included in this report. ***
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In 2007, 3.8 billion searches were conducted on yellow pages sites as well as the local listings they provide to search engines such as Google, Yahoo and others. So what are the most popular things being searched for? I'm not going to beat around the bush. Here they are:
1. Restaurants
2. Physicians & Surgeons
3. Hotels
4. Auto Repairing & Service
5. Florists-Retail
6. Auto Dealers-New & Used
7. Dentists
8. Auto Parts & Supplies – New & Used
9. Beauty Salons (tie)
10. Hospitals (tie)
This list was put out by the Yellow Pages Association. The data was collected by Knowledge Networks/SRI.
Want a little insight into yellow pages demographics?
- 63% are female
- 89% are aged 25-64
- 54% are college graduates
- 42% have lived at the same address for 10+ years
Related Reading:
Yellow Pages and Search
Q&A with Darby Sieben of the Yellow Pages Group
Yellow Pages Beat Other Local Media in Online Sales in 2007
Related reading
Why local search should be part of your ecommerce strategy
As local marketing becomes more important, it's time to focus on local search strategy in order to beat your competition.
How a customer reviews strategy can impact SEO
Chris Bullick explains at Brighton SEO why every brand needs to have a review strategy and what this means for SEO.
Google's latest algorithm update: did anything happen and what might it affect?
Friday was an exciting day for search, as the 'chatter' around a core Google algorithm increased dramatically.
Google Maps update decides which areas are "of interest" for users
If we didn't have Google Maps, we'd either never leave our homes for fear of getting lost or we'd have to find our physical maps again.


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Front Range (CO) > Pikes Peak > Climber's Log
Pikes Peak Climber's Log
[ Sign the Climber's Log ]
|Route Climbed: Barr Trail from Manitou Springs Date Climbed: September 26, 2004
|Hiked up the Barr Trail from Manitou Springs on a partly cloudy day. Having moved to Colorado Springs earlier in the year this was the third time I'd summited the great peak that is visible from my master bedroom. What a view every morning!
|Posted Oct 31, 2004 9:43 pm
|Ed F
|Route Climbed: Pikes Peak Ascent from downtown Manitou Springs Date Climbed: August 22, 2004
|Did the Pikes Peak Ascent for the first time. Crazy! It was like a cattle drive to the summit. Definitely one of the tougher things I've ever done. I only managed to run the first 2 miles and the middle 3.
13.32 miles, 7,815 vertical feet. It hurts just to see those numbers....
|Posted Oct 24, 2004 12:32 pm
|Route Climbed: Crags Date Climbed: December 29, 2002
|What a great hike! Packed trail and little snow negated the need for snowshoes or crampons. Overcast for the lower elevations, but at ~12,000 ft we popped out over the clouds and had sunshine the remainder of the hike. VERY, VERY, cold though with high winds. Was very thankful for my balaclava and goggles. Kind of eerie at the top with the gift shop shutdown and not a soul to be found...I'm so used to 100's of tourists milling about with donuts and cigarettes in hand. :)
|Posted Oct 14, 2004 2:52 pm
|Route Climbed: Northwest Slopes Date Climbed: June 3, 2000
|My first time climbing this mountain from Crags Campground took 4.5 hours to the summit. We met family at the summit and got a ride down, but estimated about 2 hours to get back to the trailhead.
The route was a bit murky at first after crossing the stream, but once we got onto the old mining road, the route was apparent. My last time on this route there were better signs pointing the way, and there were alot more people on this route versus the standard Barr Trail route.
|Posted Oct 12, 2004 10:03 am
|Route Climbed: Northwest Slopes Date Climbed: July 14, 2001
|Started from Crags Campground, and ascended to the summit in about 6 hours. Lots of kids on this route - some who did not know where the summit was. Clouds moved in later in the day even though there were still climbers enroute.
|Posted Oct 12, 2004 8:51 am
|Route Climbed: Barr Trail Date Climbed: June or July 1998 or 1999
|Good hike- really long. We had a van waiting for us at the summit. So it was just a one way trip. A guy in the group brought a 5000 ci pack and ended up having the female leader carry it (along with two other packs) to the summit.
started off with beautiful weather and ended up with a few hikers near hipothermic. Wind, sleet and snow the last 750 vert. feet.
|Posted Sep 30, 2004 2:53 pm
|Route Climbed: Barr Trail Date Climbed: September 26, 2004
|Hiked to the Barr camp on Saturday September 25, 2004 and spent the night at the camp. The hike was very easy and the trail was as good as any I've hiked. Sunday September 26, 2004 my Dad and I were on the trail at 5:45am and made the summit in 4.5 hours with a long break along the way. After spending an hour on the summit and eating a doughnut in the cafeteria we started on our way down. 2.5 hours to the Barr camp and then another 2 hours to the car. This was my 53rd 14er summit which now just leaves Culebra.
|Posted Sep 27, 2004 11:20 pm
|Route Climbed: Drive up Date Climbed: 8-13-04
|It was cold and windy, but the sky was so clear: no rain, no thunderstorm; blue sky. I stayed there for couple hours. Saw people getting out from the tram, took some nice pictures.
|Posted Aug 20, 2004 3:35 pm
|Route Climbed: Crags Date Climbed: August 8, 2004
|We started at 4 AM, and we got to watch the sunrise from Devil's Playground. Absolutely stunning views! This was my first 14er, and I'm looking forward to many more.
|Posted Aug 9, 2004 12:50 pm
|Route Climbed: Barr Trail Date Climbed: September 2003
|I started out at 6:00 am towards the Barr Camp. After recahing the Barr Camp, we camped in bivy's to get use to the altitude. In the moring we hiked to the shelter (base camp) and ditched our heavy items. After hiding out stuff, we hiked the rest of the way to the top. After an hour break at the top, we hiked back down and stayed the night at the shelter. In the moring we hiked out. WOW!!!! This is a great climb!!!!
|Posted Jul 26, 2004 1:59 am
|Route Climbed: Toll Road Date Climbed: About 1967
|We drove up that road there in about 1967. A tour service brought us up and I'll never forget getting up there in that ol' black 60s car. Plus, I recall seeing the white Pikes Peak from the distance. I was only about 3 years old.
|Posted Jun 22, 2004 12:15 am
|Route Climbed: West Fork Date Climbed: June 6, 2004
|Beautiful day along a great route. This was my 3rd summit of Pikes via my 3rd route. Had to hurry to avoid sudden thunderstorms on the way down.
|Posted Jun 8, 2004 4:08 am
|Route Climbed: Northwest Slopes (Crags) Date Climbed: May 23, 2004
|Great day to go to the top, despite late start. Route finding was a little difficult with all the snow that is still up there. Had a bacon cheeseburger and fries at the summit restaurant that were not half bad! Great company on the way down with Jim and Tim.
|Posted May 23, 2004 9:36 pm
|Route Climbed: crags (W) Date Climbed: aug 02
|my final 14er for the grand slam, actually 55th at the time. uneventful, but satisfying.
|Posted May 21, 2004 9:17 pm
|Route Climbed: Barr Trail Date Climbed: July 2001
|The Barr Trail, albeit busy, was a wonderful hike. We backpacked up to Barr Camp the first day and day hiked up the next. Great hike...the top is a little anti-climatic as you have to find the summit in the middle of a parking lot, but that's the way it goes.
|Posted May 12, 2004 3:02 pm
|Route Climbed: Barr Trail Date Climbed: 8 May 2004
|Climbed solo, one-day from Barr Trailhead. Reached Barr Camp after 2hrs 20min...summit after 7hrs 15min. I was fifth to summit that day and followed everyone else's route straight up the East Face which was soft and fairly deep. Strangely, nobody else was using snowshoes.
|Posted May 9, 2004 11:31 pm
|Larry V
|Route Climbed: Northwest Slopes Date Climbed: June 2002
|My second time to summit (on foot), first time to descend on foot. I recommend this route over the Barr Trail, by far. Driving up the road is enjoyable too, if you're not into hiking.
|Posted Apr 18, 2004 4:16 pm
|Route Climbed: Northwest Slopes Date Climbed: December 14, 2002
|We hiked on bare ground for much of this hike, which was a surprise to me at the time. I didn't know Pikes gets so little snow. A trip report is available here.
|Posted Apr 12, 2004 12:32 pm
|Route Climbed: Barr Trail Date Climbed: May 2001
|The trip was worth the look on the faces of the geriatrics crew piling off of the train with ice hanging from the beard and an axe in hand!!! The Care takers at the camp were all over the dognuts that we took back from the summit!
|Posted Apr 10, 2004 3:38 pm
|Route Climbed: Barr Trail Date Climbed: August 1989
|Wow, what a long day and a big first mountain to climb. Did this on a whim while in Colorado for a bike race.
|Posted Mar 22, 2004 10:08 pm


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Kauneonga Lake
Flu clinic
Senior center, 10am-noon, free w/ Medicare Care card, all others $21 for flu shot, $35 for pneumonia shot. Appointments (not necessary): ehealthscheduling.com/sullivan or 845/292-5910.
Picnic with the Conservancy
Delaware Highlands Conservancy thanks their members & volunteers at a thank-you picnic at their office, noon-4pm. Entertainment, live raptor show, bluegrass music, butterfly show, raffles & more. Bring picnic lunch; drinks & desserts provided.
Silent auction
Community United Methodist Church, doors open 7pm, calling 8pm. 845/583-4360.
Forest field day
See how a tree is taken down & turned into lumber at Delaware Highlands Conservancy, 9am-noon. RSVP: 570/656-6672.
Forest stewardship field day
Take a walk across Delaware Highlands Conservancy, learn about landowner opportunities to steward their own woods, review property's forest management plan & more, 9am-noon. RSVP: 570/226-3164 or 845/583-1010.
Jewish film festival
"The Infidel" at Beekman Pavilion, 8pm, $7. 917/657-5248.
Jewish film festival
"The Syrian Bride" at Beekman Pavilion, 8pm, $7. 917/657-5248.
Yeshua Festival
Share the love of Jesus Christ w/ free school supplies & clothing w/ live music at Woodstock Christian Congregation Bethel, 11am-4pm. email@example.com
Farmers' market
Fireman's pavilion, Fri.m 2:30-6pm. 845/985-2425.
Melave Malka dinner
Congregation Beth Sinai/White Lake Torah Center, 10pm, all welcome. Honored dignitaries, politicians & entertainment. 845/583-7374.


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Nature's Gate Herbal Daily Cleansing Shampoo
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Herbal Shampoo gently cleanses hair with the perfect blend of herbs and botanicals. Sage, lavender, rosemary and thyme purify and revitalize hair while chamomile and yarrow soothe and tone. With the nourishing benefits of seven healthy hair nutrients, this shampoo is ideal for everyday use on all hair types, leaving hair soft and manageable.


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Get a case for every occasion! Through the Case Loyalty Program from Verizon, you can buy more and save more. Buy any standard case and receive an email offer for discounts on subsequent case purchases.
For full details, check out the Case Loyalty Program guide.
The Incipio DualPro™ for the iPhone 6/6s features a dual layer design that consists of an impact resistant silicone core and a rigid Plextonium™ frame. The case defends the new iPhone 6/6s against daily wear and tear, dirt, dust and minor damage without sacrificing style.
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text: What is this spirituality about? Learn about a spirituality that is down to earth, optimistic and filled with practical common sense ideas. Read More → Sacred Artwork Bro. Mickey McGrath shares the healing power of art and the hope it can bring. His creative and whimsical images will help you discover joy within your heart. Read More → Bookstore Over 125 titles and recordings for both the beginner and those looking to deepen their knowledge and their relationship with God.. Read a current author or discover the classic writings of Saint Francis himself. Read More → Parish Missions A time for the whole parish to come together to reflect upon God's word, to renew faith, and to pray with open hearts and hands. Read More → New to Salesian Spirituality? Browse our books for beginners section and find something that will help you, "Be who you are and be that perfectly well." – Saint Francis de Sales Featured Resources St. Francis de Sales and St. John Neumann – 11×14 – P...$ 15.00Add to cartDrawing Closer to God...$ 10.00Add to cartIn a Nutshell$ 10.00Add to cartKids and Prayer DVD$ 35.00Add to cartJesus, Merciful Savior DVD...$ 20.00Add to cartMary, Full of Grace DVD...$ 20.00Add to cartFalling in Love with God...$ 20.00Add to cartLetting Go, Hanging On: A Guide for the Spiritual Journey by John L. G...$ 14.95Add to cartHeart of Hearts, A Collection of Essays by Joseph F. Power, OSFS...$ 14.95Add to cartGood Saint John XXIII...$ 20.00Add to cartRoses Among Thorns$ 12.00Add to cart .


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Review Details
Rook Wallet
- Product Review (submitted on April 26, 2013):
Looks cool, been asked more than once where I got it, def not a wallet that every other guy is carrying. I was a little concerned about the size since I carried a small leather card holder from Eddie Bauer for a wallet for 10 years and kept my cash in my front pocket. But it's mostly molded to my butt now so I hardly notice it when I'm sitting. Only have 3 issues. 1: The coin thingy is not good for much, I thought it held more coins, and since I was going to be in France for 2 weeks I thought I could keep my euro coins in it, but no. But overall not a big prob. 2: As other review(s) stated, the wallet frays and the strings/fuzz have to be burnt off with a lighter. Again, no big prob, but it's a tad annoying. 3: The card slots are a little sticky but maybe that'll improve with time/use. Ok, one more thing. The white color is starting to wear off already. :o(
But overall it's cool, I'd buy it again for myself or as a gift.


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Corkey Windfarm
Corkey Windfarm was constructed in 1994 and is located near Clogh Mills in County Antrim.
At this ScottishPower Renewables site, ten Nordtank turbines produce up to five megawatts of cleaner greener energy.
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Jump to navigation
Source: Bang Showbiz NewsAmy Adams forgets she is famous and is left bemused when people stop her in the street.The 'Trouble with the Curve' star - who has two-year-old daughter Aviana with fiance Darren Le Gallo - says finding fame relatively late in life means she still views herself as the "poor girl from Colorado" and she is always shocked when people stop her in the street.In an interview in The Guardian newspaper, the 38-year-old actress said: "I still think I'm like the poor girl from Colorado who worked three jobs to buy a car. That's still my mentality, so I'll be walking down the street, and I forget what I do and who I am. Someone will come up to me and say hi, and I'm thinking, I must know you, and I realise that, no, I don't know them and they don't know me. At all!"Amy was catapulted to worldwide fame by 2007 Disney movie 'Enchanted' and followed it up with prominent roles in 'The Fighter', 'The Muppets' and 'On The Road'. And the screen beauty believes her early years travelling around because of her father Richard Kent's career in the US military taught her useful skills for her Hollywood career. She explained: "It definitely makes you a little bit more transient, which can turn out to be a good quality in life, and in fact has helped me in what I do ... What it really does is teach you how to adapt and change and fit into a new group or school, and that really is a lot like turning up to a new movie project and finding your place."


text: Sam Schatz 735pages on this wiki Add New Page Edit Classic editor History Add New Page Talk0 This article is written from aReal World perspective. Sam Schatz in the TRON pre-production test Sam Schatz is a Frisbee champion who helped train the actors in TRON to utilize the frisbee for the fight scenes in the movie. He also appeared in the TRON pre-production test where he was wearing a rudimentary program costume. GalleryEdit Add a photo to this gallery Retrieved from "http://tron.wikia.com/wiki/Sam_Schatz?oldid=39990" Categories: Real Life TRON Crew Performers TRON Performers People Add category Cancel Save