text:
Ergonomics and Why It Should Be Important to You
"Ergonomics" shouldn't just be a flashy word for you. Especially if you own a business, ergonomics at work should be a top concern, for you as the business owner and for your employees. Let me explain why ergonomics are so important.
The most obvious benefit of good office ergonomics is better health. A lot of people may not know this, but many of today's health problems are coming from non-ergonomics workplaces. Among those would be health problems such as back pains, poor eyesight, even migraines can often come from less than optimal work environments.
An ergonomic workplace can help avoid many of those common health issues, which in turn can mean significant financial savings: less costs for rehabilitation, work outages and sick days, smaller insurance premiums and so fourth.
When an ergonomic workplace makes it easier and more comfortable for employees to do their job, without pain and strain, a natural result of that is that your employee's motivation and productivity will also increase. This as well can translate into higher profits. There is no need to point out that for optimal productivity workplaces need to be optimal as well.
What can you do to improve workplace ergonomics?
The first thing you should consider is whether your office furniture, such as your existing office desks and ergonomic chairs conform to modern ergonomic standards. Replacing those with ergonomic chairs and desks should not be a major issue. Often times you can address most issues with ergonomic at work as simple as that.
On the other hand, more factors can play into ergonomics that are not always evident. Aside from ergonomics chairs and desks there can be other factors as well. If you want to be entirely sure about your ergonomics, you should consider a professional work station assessment. This will help uncover every weak spot when it comes to ergonomics.
Don't make the mistake and disregard your workplace ergonomics as something less important. It can well be the needed change for your office so your business can reach new heights of productivity and motivation.
Be Careful If You Buy Stuff On Gumtree
Ebay, Gumtreee and similar "second hand" websites are always great for finding the one or the other bargain or rare treasure. Then again, if you love to shop on such websites, caution is always advised.
Did you know that Gumtree alone is hit by 250 fraud claims each end every week? Websites where private individuals can offer and sell goods on the internet are always appealing for scammers and those large sites such as Gumtree are especially liked by those criminals.
One rather common scheme on Gumtree would be that a property is offered up for rent and the alleged "landlord" is asking for a hefty security deposit in advance. When you then finally want to inspect the rental in question you will find it's not even up for rent and then your money will be long gone. Always use common sense if you do business on such websites and most importantly don't ever pay money in advance. Be aware that if something sounds to be good to be true it more often than not really is.
How Electronic Invoicing Can Benefit Your Business
There are several benefits that electronic invoicing can provide for your business.
The first and most obvious benefit of using e-invoice is the cost savings that you will see. Those savings can be biggest for those businesses that have large amounts of invoices to process. Electronic invoicing means that less work and therefore less for your invoicing will be required. There is no lengthy mailing process involved and no requirement for the tedious and error-prone process of having to type-in paper invoice data.
The ability to instantly be able to send and receive invoices means less waiting and less delays. A supplier can now provide goods or services and have their invoicing done and completed within minutes.
One major advantage of electronic invoicing is also that it can provide a considerable amount of mobility.
Contractors can now do their invoicing "on the go", while they're out in the field between customers.
With electronic invoicing apps that are available for mobile devices there is no need to return to the office to do the paperwork.
Better and easier management of your invoices
No paper invoices doesn't just mean less work and less mistakes in your invoicing process. With all your invoice data accessible centrally, the management of your invoices will also be a lot easier.
Electronic invoicing is affordable
Last but not least, businesses can take advantage of the low cost for electronic invoicing plus the fact that it won't require any special equipment. Businesses should be able to make the switch to electronic invoicing easily.
See E Invoicing so you can learn all you need to know about the modern and effective way to process your invoices.
Export Management Software Can Help Your Business Save Money
Working efficiently normally means getting a job done in the fastest yet most cost-efficient way. For some types of businesses, including my own, this is not always that easy to achieve. Let me explain.
Among of the main culprits that can often tie up a lot of time and then end up costing lots of money is everything related to management and organization.
If things go awry there, say if they're not as efficient as they could possibly be, the entire business can suffer.
In the shipping business this problem become particularly evident. Why? Because in this type of business a lot hinges on effective organization.
At some point your customer base will grow and you simply cannot afford to slack managing invoices, orders, customer inquiries and of course everything related to shipping your goods to your customers as fast as possible.
Be assured that any unhappy customer, any single delayed or missed shipment could (and normally will) backfire.
This is where business software such as export management software can help tremendously!
I have personally seen how the export management software we obtained made a big difference in daily operations:
* We can respond faster to customer inquiries
* We can fulfill orders much quicker
* We can ship items in various ways which means that we can offer the customer more choices there, including economy shipping, over-night shipping etc.
* We can now basically avoid all mistakes such as shipping the wrong items or having incomplete shipping documents for customs.
The last point alone deserves attention since proper customs documents are extremely important. For any international shipping company, when a shipment is held up in customs it is normally a minor to major catastrophe. (Most of then time it's a major one, let me assure you.) This can easily happen without export management software since a mistake on a customs form is easily made. No one can keep track of the constant changing regulations, especially if you ship to or import from China, India and similar countries.
So, to let me conclude this blog post. If you're the owner of a small business where you ship goods, export management software can be a huge time and money- saver!
How To Save Money When You Hire A Car
For your next holiday abroad, when you hire a car you could actually save a significant amount of money. We're not talking "chump change" here but the differences in costs for car hires can be anything between £250 and £600!
One tip here is that you should always hire your car as early in advance to your holiday as you can. If you already know the date of your arrival at your destination you can call up the car rental agency and book your car today. Don't wait until the last minute and definitely avoid to rent your car for your holiday right from the airport.
If you do it that way you can save a whole bunch of money, even more so if you plan to visit the popular holiday destinations in Spain or Italy. The earlier you hire your car the more you will save! You can read more about it over at The Express.


text: Dr. Levon Chookaszian, director of the UNESCO Chair of Art History at Yerevan State University, will present on "The Armenians of the Crimea and Romania as Seen through Their Art," at 7:30 p.m. Wednesday, Feb.12, at Fresno State. The free, public event will be in the Alice Peters Auditorium, Room 191, of the Peters Business Building and is part of the Armenian Studies Program Spring 2014 Lecture Series. The lecture is co-sponsored by the Virginia-based Ararat Foundation. Parking is free in Lots A or J by entering the event code in any permit dispenser located in parking lots. INFO/Parking Code: 559-278-2669 or http://www.fresnostate.edu/artshum/armenianstudies/.

subset: commoncrawl


text:
realmagick.com The shrine of knowledge.
American Idiot Plot
A selection of articles related to american idiot plot.
Original articles from our library related to the American Idiot Plot. See Table of Contents for further available material (downloadable resources) on American Idiot Plot.
- Hypnosis: A Selected Bibliography
- Index of bibliography sections Selected Periodicals (14 entries) Edited Overviews of General Theories of Hypnosis (5 entries) Specific Topics Related to Research into Hypnosis. General single-author overviews, non-special-state views, social andexperimental...
Parapsychology >> Hypnosis
- The Ten Native American Commandments
- Treat the Earth and all that dwell thereon with respect. Remain close the Great Spirit. Show great respect for your fellow beings. Work together for the benefit of all Mankind. Give assistance and kindness wherever needed. Do what you know to be right. Look...
Religions >> Native American, Shamanism
- Hypnosis References
- Bower, G. (1990). Awareness, the unconscious and repression : An experimental psychologist's perspective . In J.L. Singer (Ed.), Repression and Dissociation: Implications for personality, theory, psychopathology, and health . (Pp, 209-222). Chicago:...
Parapsychology >> Hypnosis
- Black Gospel Music
- Black Gospel music is also known as Urban Contemporary Gospel music. Its roots were the Negro spiritual songs that were sang by the African slaves while tilling the rich cotton fields of their white Southern masters in the early 18th century.
>> Poetry & Fable
- Subliminal Persuasion: References
- (1957). " Persuaders' Get Deeply 'Hidden' Tool: Subliminal Projection " Advertising Age , Vol 37, page 127, September 16, 1957. Benes, Kathryn M.., Gutkin, Terry B., Decker, T. Newell, (1990) "The effects of mellow and frenetic music on...
Parapsychology >> Subliminal Persuasion
- Principles of Wiccan Belief
- In the spring Witchmeet held April 1974 in Minneapolis, Minnesota, The Councel of American Witches adopted this statement entitled "The Principles of Wiccan Belief." The statement was created in hopes to bring awareness to the general public as well...
Religions >> Paganism & Wicca
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text:
By Martin Mutua
Juja legislator William Kabogo appeared before the National Cohesion and Integration Commission (NCIC) to answer to hate speech claims against him while his Starehe counterpart Margaret Wanjiru is expected to show up today.
Kabogo and Wanjiru had been accused by the Law Society of Kenya (LSK) of hate speech while the Juja MP also faced another charge from the Hindu Council of Kenya (HCK) for allegedly making unflattering remarks against Kenyans of Indian origin.
Speaking to the media on Monday at NCIC offices in Nairobi after recording a statement with NCIC investigators and legal officers, Kabogo denied claims that he incited Kenyans against the rule of law as LSK alleged.
He is accused of promising to reject any court decision that may bar Deputy Prime Minister Uhuru Kenyatta and Eldoret North MP William Ruto from the 2013 presidential elections over integrity issues.
"LSK must understand what hate speech is all about. I meant that if we lose the case in High Court, we will go to the Court of Appeal, if we lose we go to the Supreme Court, if we lose, we go to the East African Court of Justice. We will follow the law till the end. There was no hate speech at all," he said.
Regarding the alleged anti-Indians complaint, Kabogo insisted his views were misrepresented by a section of the print media that reported it several times this month.
The Juja MP also insisted he never said that no Kenyan of Indian origin would get a tender or contract in Kiambu County.
Lucrative contracts
He added he had emphasised that lucrative contracts would go to youths, no matter their ethnic background.
When contacted, HCK promised to release a statement over the matter today.
He called on the media to be more careful and responsible in their reporting to avoid sparking destructive tension and conflict in the country or plunging individuals into trouble with the law.


text:
Peppermint was definitely the flavor of the holidays this year, and I saw more specialty peppermint goodies than ever before – and this includes products in the baking aisle, not just in the bakery case. Trader Joe's Peppermint Bark Baking Bits are just one example of some mint-infused baking supplies that I picked up during my holiday shopping. The bits are crushed up peppermint bark, ... Read More »
Tag Archives: peppermint
5 Treats to Bake with Candy Canes
I get a lot of candy canes during the holidays. I like to hang them on my Christmas tree and stir them into my coffee and hot chocolate to give some holiday flavor to my drinks. Candy canes can also be a surprisingly fun ingredient to bake with. They are a great way to infuse a little bit of holiday spirit into baked goods or ... Read More »
Peppermint and Cacao Nib Bark
Peppermint bark is a type of chocolate bark where layers of white, dark and/or milk chocolate are topped off with a generous sprinkle of crushed peppermint candies. Many big chocolate brands, including Dove and Ghirardelli, release their own take on peppermint bark during the holidays, and even Haagen-Dazs has a limited edition peppermint bark ice cream flavor. But peppermint bark is easy to make at ... Read More »
Candy Cane Oreo Pound Cake
Oreo has been releasing limited edition holiday cookies for some time now, and this year's Candy Cane Oreos are proving to be a very popular addition to the lineup. The cookies feature the standard chocolate wafers found on most Oreos, but have a peppermint filling that is red, white and speckled with slightly crunchy candy cane bits. The peppermint isn't too strong and it is ... Read More »
Andes Peppermint Crunch Baking Chips, reviewed
The bright red packaging of Andes Peppermint Crunch Baking Chips definitely caught my eye on the baking aisle last time I was stocking up at the store. The chips are a seasonal item, just around for the Christmas holiday season. They're creamy faux white chocolate chips that have a festive read and white look and a minty peppermint flavor. I don't usually go for faux ... Read More »
White Chocolate Peppermint Crunch Blondies
Peppermint is often paired with dark chocolate, but it can be an excellent match for white chocolate, too. White chocolate is creamy and sweet, and can serve as a very nice counterpoint to strong, bright peppermint. This is exactly how these flavors come together in these White Chocolate Peppermint Crunch Blondies. The easy to make bar cookies are buttery, chewy and tender, with a creamy ... Read More »
Shamrock Chocolate Peppermint Cookies
A four leaf clover is good luck any day of the year, but a few clovers are an especially nice way of finishing off these St Patrick's Day themed Shamrock Chocolate Peppermint Cookies. The cookies are tender, chocolate wafers that are topped with minty green shamrocks. They're easy to make, flavorful and definitely look festive enough for any St Patrick's Day celebration. The cookies are ... Read More »
No-Churn Chocolate Mint Chocolate Chip Ice Cream
It is great to have an ice cream maker at home if you're a big ice cream lover. Homemade ice cream, straight out of the machine, is something that is hard to beat with storebought products. It's also fun because it is so easy to customize the ice cream with your favorite mix-ins, whether you like to add crushed up Oreo cookies or a swirl ... Read More »


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SPARTA — A freight train derailment that threw three huge tanks of refrigerated liquid carbon dioxide down a small embankment is still being investigated this morning, authorities said.
The New York Susquehanna and Western Railway train derailment led to no injuries and no evacuations when it occurred Wednesday night at 11:31 p.m., said Sgt. John-Paul Beebe of the Sparta police.
The freight train had just departed the Linde North America Inc. plan on Demarest Road in the township when the three cars – totaling 170 feet in length and weighing 395 total tons – tumbled down a small embankment nearly a mile north of Route 15 and Houses Corner Road, Beebe said.
The Sparta Fire Department came to the scene, but it was quickly determined that there were no Hazmat threats from the accident, Beebe said.
The cause of the freight train derailment has not yet been determined, Beebe added.
Refrigerated liquid carbon dioxide is a colorless liquid used in freezing food, controlling chemical reactions, and for extinguishing fires, the sergeant said. However, it can cause asphyxiation by displacement of air – and exposure of containers to heat sources can cause it to rupture violently and even rocket, the sergeant said.
Linde North America specializes in industrial gases and engineering, according to the company's website. It employs 5,000 in the United States and its North American headquarters is located in Murray Hill.


text:
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text:
Subject-area placement tests and challenge exams are offered to new students during Threshold and/or the first week of classes each semester. Some exams may be completed through individually scheduled appointments. The challenge exams North Park currently offers are listed below.
Guidelines and policies for subject placement tests and challenge exams are subject to change without notification.
In order to fulfill the foreign language requirement at North Park, you will need to decide if you want to continue in a language previously studied or know, or begin a new language. You must be proficient through the 1020 level to meet the foreign language Core Curriculum requirement.
Foreign language challenge exams measure whether you have the language skills equivalent to students who have taken first-year university foreign languages at the 1010 and/or 1020 levels. Learn more about the options for these challenge examinations.
Math placement depends on the your ACT/SAT math subscore as well as the intended major. Based on these factors you may need to take prerequisite courses prior to fulfilling the Core Curriculum and/or major requirements.
When you register for the first time at North Park, you will be informed of your math placement based on the above criteria. You may choose to challenge the math placement by taking the Math Challenge Test. You may not test backwards and place into a lower level course. The Math Challenge Test is offered during Threshold Week and/or at the beginning of each semester. To take the Math Challenge Exam at a time other than the beginning of each semester, you will need to contact the Math Department.
Courses that fulfill the math Core Curriculum requirement are:
Guidelines and policies are subject to change without notification.
All incoming freshman who intend to major, minor, or take a concentration in music, or non-majors who are interested in taking music theory, are required to take the Fundamental Music Theory and Aural Skills Placement. This placement tool assesses rudimentary music theory and aural skills concepts such as reading pitches in treble and bass clefs, basic rhythmic patterns, understanding rhythm and meter, the major scales, and major key signatures.
Any student with a score under the requirement for MUS 1080 (Introduction to Musicianship) placement will be required to take MUS 1060 and/or MUS 1065 (Fundamentals of Music Theory), which are a prerequisite to MUS 1080. Students who score exceptionally well may be asked to take our Advanced Music Theory and Aural Skills Placement.
The placement takes approximately 30 minutes and is offered twice in the early spring, in conjunction with our entrance auditions, during Threshold Week, and by appointment. To schedule a time to take this placement, please contact Dr. Rebecca Ryan at (773) 244-5623.
All transfer students who intend to major, minor, or take a concentration in music are required to take this placement for theory and aural skills. Additionally, first year students who score exceptionally well on the Fundamental Music Theory and Aural Skills Placement may be asked to take the Advanced Music Theory and Aural Skills Placement for the opportunity to place higher in our music theory and aural skills course sequence. The placement is comprised of three sections:
This placement and a music transcript evaluation are required before you can register for theory and/or aural skills classes however, for registration purposes, students may be temporarily registered for placeholders until evaluation and a placement has been completed.
This placement is offered twice a year, during fall and spring Threshold. Those who need this placement must take it when it is scheduled; no individual appointments for this placement are available. To sign up for this placement, please contact Dr. Rebecca Ryan at (773) 244-5623.
All first-year and transfer students who intend to major, minor, or take a concentration in music are required to take a keyboard placement test. Placements are offered in the spring, in conjunction with our entrance auditions, during Threshold, and by appointment.
The keyboard placement test will consist of a short (5 to 10 minute) consultation to evaluate correct placement in Keyboard Skills courses. Students will be asked to play scales, chords, and perform sight-reading—levels of which will be based on conversations with the evaluator.
For registration purposes, students may be temporarily placed in Keyboard Skills level I or II until a music transcript evaluation and a placement test has been completed.
To schedule a time to complete your keyboard placement, please contact Dr. Terree Shofner-Emrich at (773) 244-5632. Non-majors interested in piano lessons and keyboard skills courses should also contact Dr. Shofner-Emrich.
All students registered for voice lessons, or interested in taking lessons, are required to meet with Dr. You-Seong Kim for teacher placement. Placements are offered during Threshold and can be scheduled by contacting Dr. Kim at (773) 244-5626. Placements must be completed before the end of the first week of class.
Any student interested in auditioning for a choral or instrumental ensemble should sign up for an audition during Threshold in Hanson Hall. Auditions will be held during the first week of class. Learn more.
You are allowed to take the Writing Challenge Exam if you wish to challenge placement in WRIT 1000. Placement in a WRIT 1000 course is based on the following criteria:
No additional course is needed
WRIT 1000 is a prerequisite for the Core Curriculum requirement, NPD 1000: Cornerstone Seminar. Students must earn a minimum of C- in WRIT 1000 order to enroll in NPD 1000.
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text:
Compugen Ltd. (NASDAQ:CGEN)
Q3 2012 Earnings Conference Call
November 05, 2012 10:00 AM ET
Martin Gerstel – Chairman
Dr. Anat Cohen-Dayag – President and CEO
Dikla Czaczkes Axselbrad – CFO
Mara Goldstein – Cantor Fitzgerald
Brett Reiss – Janney Montgomery Scott
Klaus Von Stutterheim – Deutsche Bank
Ladies and gentlemen, thank you for standing by. Welcome to the Compugen Ltd., Third Quarter 2012 Financial Results Conference call. All participants are at present in a listen-only mode. Following management's formal presentation, instructions will be given for the question-and-answer session. (Operator Instructions)
As a reminder, this conference is being recorded, August 7, 2012. With us online today are Mr. Martin Gerstel, Chairman of the Board, Dr. Anat Cohen-Dayag, President and CEO and Ms. Dikla Czaczkes Axselbrad, CFO.
I would like to remind everyone that the Safe Harbor language contained in today's press release also pertains to all content of this conference call. If you have not received a copy of today's release and would like to do so, please contact Dikla Czaczkes Axselbrad at 972-376-585-95. Mr. Gerstel, you canbegin.
Martin Gerstel
Thank you very much. On behalf of my associates, all the employees of Compugen, welcome to our delayed Q3 2012 conference call. Thanks for joining us. First, for those of you and your families who were impacted personally by the devastating storms last week affecting the eastern United States, we hope you are fully recovered or at least are on the way to full recovery and our best wishes are with you.
Less than three years ago, Compugen selected Fc fusion and monoclonal antibody therapeutics for oncology and immunology as our first areas of focus. The results since then, which were largely achieved during the past two years, have been more than impressive and almost certainly unprecedented in the pharma industry and are now conclusively demonstrating to leading companies in the industry the power of the unique, predictive, discovery infrastructure that has been established at Compugen. Today, we have an internally discovered Pipeline of about 30 candidates for targeted medicines in key areas of significant unmet medical need and high industry interest, about half of which are moving forward with priority validation and development.
In addition, during this time period, we have successfully integrated in-house expertise and development capabilities for both arms of our pipeline, while maintaining and enhancing our computational discovery leadership. However, as a pioneering company in an area with a history of failures by many others, in order to attain success as a public company, Compugen requires the positive recognition of three important audiences; he scientific communities, the pharmaceutical industry and the financial community and most certainly in that order.
With respect to the scientific community, this recognition begun to be achieved from our earliest years as our scientists made important breakthroughs in the predictive understandings of key biological phenomena at the molecular level such as alternative splicing, naturally occurring antisense, pseudogenes, so called junk DNA and others, often contradicting what was generally believed at the time. But although these scientific achievements were to prove fundamental in building our competitive advantage in predictive discovery, they had and for good reasons, only a minor impact in the industry and even less in the financial community.
The second required recognition, that of the pharmaceutical industry, has been more difficult. In view of so many past failures, both internally and externally with predictive biology approaches, it soon became apparent to us that the only path to recognition would be in the form of results, not promises nor great sounding science. Fortunately now with very attractive product candidates successfully moving forward in our pipeline, we are rapidly achieving the second required recognition. As we continue to have an increasing number of extensive interactions with major pharmaceutical companies in North America, Europe and Asia, which have more than doubled in number since our last quarterly call, we are receiving very positive feedback both with respect to our unique discovery capabilities and with respect to potential collaborations covering our leading product candidates.
This now leaves us with only the third and final required recognition for success as a public company, that of the financial community itself. It is important to note that in general, the financial community values modest sized or even sometimes large biopharma companies based on an evaluation of the potential and status of such companies' one or two lead products. This methodology usually makes sense in view of the fact that success or failure for these companies most likely would be dependent on that product or products and if they fail as unfortunately so often they do, in many cases or almost – all or almost all shareholder value would be lost.
However, Compugen's product oriented achievements starting the past three years in terms of both quantity and quality, are showing that this is not the case for us. As previously stated, the number of novel candidates discovered by us and their very positive in vitro and in vivo experimental results, exceeding even our own expectations, is more than impressive and that is so even without considering that these are the results from only our initial discovery efforts in our first fields of focus.
Now, as leading companies in the pharmaceutical industry begin to validate this assessment of our unique discovery capabilities and attractive product candidates, the financial community should obtain the required information it needs to properly value Compugen as a publicly owned company.
In today's call, Dikla will next comment on our financial results for the quarter, which were as anticipated other than a lesser than expected net burn due to timing issues and then Anat will provide more insight into the basis for our confidence that the stage has now been set for the short term and continuing demonstration by Compugen of the exceptional medical and financial values that have been established over more than a decade by our superb, multi disciplinary scientific team. We will then open the calls for any questions that you might have. Dikla?
Dikla Czaczkes Axselbrad
Thank you, Martin. As Martin mentioned, our financial results for the quarter were in line with our expectation. However, there are a few items that deserve further explanation. The approximately $100,000 in revenue for both the third quarter of 2012 and the nine months ending September 30, 2012, represent a payment of certain research activities we performed for our joint venture with Merck-Serono that was announced in June this year.
The net loss of $8.3 million for the nine months of 2012 compared with $7.7 million for the first nine months of 2011 include $1.3 million in non-cash charges related to the complicated accounting required for the basic arrangements, compared to $800,000 in the first nine months of 2011 for this arrangement.
The reported increase of about $1.9 million in R&D expenses net for the first nine months of 2012 is largely due to establishment and initiation of activities at the South San Francisco facility as well as increasing level of activities in the company's pipeline program. Higher pipeline cost involved independent investigated and service providers performing evaluation studies and an increased usage of lab material. Increased R&D expenses also reflect the impact of low governmental grants compared with 2011 given that such grants are deducted from research and development expenses.
This increased level of R&D activity and in particular the establishment and initiation of activities at the South San Francisco operation also explained the increased level of fixed assets at the end of the quarter.
With respect to our current cash status, we ended the third quarter of 2012 with approximately $20.1 million in cash and cash related account. This total of $20.1 million does not include $5 million due to be received later in 2012 under the second phase research and development funding arrangement, or the montage value of our Evogene shares. In addition, Compugen continues to have no long term debt other than the book liability associated with the research and development funding arrangement.
And with that, I will turn the call over to Anat.
Dr. Anat Cohen-Dayag
Thank you Dikla. As Martin mentioned, less than three years ago, Compugen selected protein therapeutics, namely Fc Fusion and monoclonal antibodies for oncology and immunology as our first areas of focus. In my prepared remarks today, I would like to provide you with an overview of our product related accomplishments since then in terms of both quantity and quality.
We are now receiving clear and positive feedback from major pharmaceutical companies in terms of appreciation of and interest in both our unique discovery capabilities and our leading product candidates. Since we have a high degree of confidence that this will result in the type of validation required by the financial community to properly value both our pipeline and our company, we believe it is important for us to communicate these achievements to our shareholders.
Primarily during the past two years, we have pursued validation of our product candidate in parallel with early stage development activities involving our prioritized list of candidates. This has included numerous experimental studies supporting the progress of the execution program and its respective antibody target program. These studies performed both in-house and by our network of collaborators, included this cord test to demonstrate that the novel molecules has the predicted activities and specifically for the Fc Fusion, multiple in vitro experiments using these animal models that the industry relies on to validate these product candidate.
Our average rate of success for all of these validation studies has been far in excess of 50% demonstrating conclusively the following accuracy of our predictive capabilities. For example, the fact that five out of the six Fc Fusion product candidates based on our novel B7-like prediction, have shown positive results in relevant autoimmune disease model has been referred to by several experts in the field and potential pharma partner as remarkable.
The therapeutic potential of our multiple product candidates have allowed us to establish a network of outstanding collaborators, key opinion leaders and expert consultants who are helping us to advance our pipeline through diverse guidance and or active implementation. You will be hearing more about these collaborations in the coming months.
Moving now more specifically to our pipeline, approximately half of our candidates consist of novel targets for antibody therapy in cancer, while another half consists of execution therapeutics for autoimmune diseases. A significant number of our pipeline candidates are based on our discovery of multiple B7/CD28 immune checkpoint proteins, which represent our first proper discovery effort using the integrated infrastructure established over the prior decade.
The B7/CD28-like immune checkpoint proteins are exciting discoveries as they represent a very promising approach to fight diseases like cancer and autoimmune diseases through the modulation of the immune system. Each immune checkpoint protein ahs the potential to serve as a target for antibody cancer therapy, whereas the extracellular domain which is the portion of the molecule that recognizes the immune system may form the basis of an execution protein for the treatment of autoimmune diseases.
Since the modulation of the immune system by immune checkpoints is perhaps the most exciting approach in cancer and autoimmune disease therapy, it is not surprising that significant efforts have been spent by others in discovery attempts. Consequently, our discovery of nine such markers is perceived as very impressive by the major pharmaceutical companies with whom we are in discussions as well as by key opinion leaders in this field.
With respect to Fc Fusion proteins, the better we understand the mechanisms of action of our candidates, the better we can use them to specifically target additional therapeutic indications as well as differentiate them from know therapeutic agents. Deeper understanding of the mechanisms perfection also allows the selection of the optimal indication for the clinical development of the drug candidate.
Our Fc Fusion proteins modulate immune response through a negative co-stimulatory effect specifically exerted through the modulation of T-cells which are major players in the protein adaptive immune response in autoimmune diseases. We recently have expanded our mode of action studies to include additional T-cell subtypes. In this respect, we recently reported that CGEN-15001 also promotes inducible regulatory T-cells or iTregs that are key anti inflammatory cells in addition to its previously reported inhibitory effect on inflammatory T-cells.
iTreg induction is considered an extremely promising approach for treatment of autoimmunity and also suggests a compelling mechanism of action as a cancer target for CGEN-15001T. the Compugen discovered B7/CD28 type protein on which the CGEN-15001 Fc Fusion protein is based.
With respect to antibody therapy for cancer, the value of an antibody drug is largely dependent on the attribute of the target that it recognizes and binds to. At Compugen, the discovery efforts for novel antibody targets takes place in Israel and during the past three years we have discovered a large number of very attractive novel targets.
As disclosed in our press release last Wednesday, recent results demonstrate that our dress targets may offer various modes of action and may impact multiple disease indications for cancer treatment. In addition to our previously disclosed results for other Compugen B7 (inaudible) iTreg target, the recent results we disclosed for two of our drug targets suggests that their mode of action affects both arms of the immune response, DNA and adaptive immune responses with specific modulation of key immune cells.
We are very pleased by the continued broadening of our early stage oncology pipeline and its potential to provide distinct and effective solutions for multiple types of cancer through utilization of therapeutic antibodies. This is particularly important in view of the understanding that combination of multiple modes of action will be required in the pursuit of effective cancer treatment.
Earlier this year, we established Compugen Inc. in South San Francisco for the development of monoclonal antibodies against Compugen discovered targets as therapeutic product candidates. As previously stated, the core value of an antibody therapeutic is directly tied to the attributes of the target. Validated antibodies against novel targets for oncology with characteristics of immune checkpoints such as those discovered by Compugen are considered to be among the most attractive product candidates in the industry and have been termed the next frontier in oncology.
At our South San Francisco subsidiary, we have quickly and efficiently formed a team that consists of scientists with extensive industry experience in the fields of therapeutic human antibody discovery and preclinical development. To date, this team has initiated antibody discovery programs for three drug targets, with several binding antibodies already identified for two of these targets.
Compugen Inc. is using two distinct pathways for the identification of antibodies against our target. The first involves in-house screening of a library of fully human antibodies using our target proteins and the second relies on the generation of mouse antibodies by a hybrid donor approach through outsourcing. Such a mouse antibody will later be immunized in expat for product development. Having access to the two different approaches increases our throughput capacity and allows the team to select the methodology most suited for each target in order to increase its probability of success.
We are focusing on two different types of antibody therapeutics to serve as the actual drug product. First are the so-called naked antibodies that are designed to block or enhance the action of a target. Such antibodies are appropriate for immune checkpoint regulatory proteins. They are expected to remove the proteins inhibitory effect on the immune cells and therefore enhance anti tumor immunity and increase the efficacy of cancer immunotherapy. This type of antibody therapy is of great interest to many leading pharma companies due to recent results observed with Bristol Myers Squibb antibodies.
These two BMS antibodies, each of which block a known immune checkpoint, have lately demonstrated impressive clinical benefit even for end stage patients, most notably unprecedented durable responses and long term survivors. The second type of antibodies we're focusing on are antibody drug conjugates known as AVCs which have already shown strong clinical proof of concept by pharma companies. In this approach, the antibody is linked to a known high potency chemotherapeutic agent also called the payload.
In this case, the antibody specifically targets the cancer cell when the payload is released and it selectively kills the cancer cell. Specificity is primarily determined by high target expression on the tumor cells with little or no expression on normal tissue. Using our MEG database, we have been able to identify a number of proteins that meet those expression criteria and we are currently validating them as ADC targets and cancer.
Before closing, I want to say a few words about our continuing activities with respect to our unique and broadly applicable predictive discovery infrastructure. Since this is what has allowed us to establish our very impressive pipeline in less than three years and is the base on which future directions of the company will depend. Our major infrastructure activities at present relate to developing new discovery algorithms and mixing and matching existing algorithms to focus on the discovery of additional drug candidates.
In addition, we are incorporating to this unique discovery infrastructure of multiple discovery platforms, predictive algorithm and computation of biology to new capabilities such as the ability to include the analysis of next generation sequencing data which was announced in July.
And with that, we will begin the Q&A portion of this conference call. We will be grateful if each time you are recognized by the moderator you will limit your question to one plus a short follow up if necessary.
Question-and-Answer Session
Thank you. Ladies and gentlemen, at this time we will begin the question-and-answer session (operator instructions). Please stand by while we pool for your questions. The first question is from Mara Goldstein, of Cantor Fitzgerald. Please go ahead.
Mara Goldstein – Cantor Fitzgerald
Thanks very much. Can you hear me?
Martin Gerstel
Mara Goldstein – Cantor Fitzgerald
Great. Just briefly on the San Francisco operations. I am just wondering about the status of staffing there. Just thinking back to the last conference call and discussions of adding personnel there. And I am also interested in the checkpoint inhibitor program. And given this area is incredibly busy area and lots of interest in these programs on the part of the pharmaceuticals and clinical development. Well, I'm just wondering what your thoughts are in terms of how far to advance what you have before looking to monetize it for the partner.
Anat Cohen-Dayag
Okay. So it relates – first, to your first question about our San Francisco subsidiary. We've started discussing. We are almost done with it. Most of the staff is there already, started to work. Work was initiated full steam ahead and couple of drug charges that were already transferred from Israel to Inc and we are very happy with the first results that were seeing. As I stated we already have two programs that are showing some heat with antibodies from the three that we've initiated. With respect to checkpoint proteins, it's a very good question. There is the real hype in this area as I stated in my remarks mainly due to the BMS results that were published in last our co-meeting in June and this gave such a boost to this field.
Of course there are a couple of companies that already have started the generation of antibodies to non-target, mainly working on PG1, PTL4 which are known immune checkpoints, which were discovered long ago. By the way we were using this an in-check point also in our discovery effort in order to find, tune our discovery parameters and to make sure that we are discovery stuff that is on one hand belong to this family but on the other hand maybe differentiated from this immune check points, and it is currently a field that is moving fast. We feel that we were able to come up with this discovery at the right point of time with respect to the fact that we are not now at a stage of just making the discoveries, we have made them some time ago.
We already have packages that are showing, starting to show the superiority of this molecules as compared to other molecules that are in the public domain that are not in development at all even and for molecules that are in development. By the way, not all the molecules could serve as therapeutic entities. They are molecules that are in the public domain and we feel that the packages that we have generated up till now, specifically for CGEN-15001 are of interest. We are very happy with the results that we are getting with the differentiation and superiority profiles that we could generate and while moving forward, full steam ahead in terms of R&D plans, we are in discussions with the Pharma companies around leading candidate but definitely this is a good time for us to be with this programs all the time.
Martin Gerstel
Just to add from – it really is an excellent question because we must in answering that question internally; we have to take a number of factor into consideration. For example, we know that the for whatever reason the shareholders are waiting for quote 'the first collaboration to be announced'. And so we have to take that into consideration and we are fortunate in that we have a number of molecules, it's not just the typical one or two and this – so we have really a wealth of product candidates. But behind your question is the well-recognized understanding that as the further you take a product in development before you license it out you can see some very substantial increases in the returns that you get. So there clearly has to be a balance amongst these different factors and we'll deal with that and we are dealing with that as we are continue these negotiations with the various companies that we are talking with.
Mara Goldstein – Cantor Fitzgerald
Okay. Thank you. I really appreciate the color.
The next question is from Brett Reiss, of Janney Montgomery Scott. Please go ahead.
Brett Reiss – Janney Montgomery Scott
Hi. Can you hear me?
Martin Gerstel
Yes, we can.
Brett Reiss – Janney Montgomery Scott
Great. What's the aggregate amount of large Pharma companies you are having these discussions on and is there any first mover advantage by any particular Pharma company to strike the first material deal with you?
Martin Gerstel
We'll, I think as we said we are talking with a number of companies and the fact that we stated that these are companies from North America, Europe and Asia I think will give you a feeling that there are a number of companies there. If it's a reasonable number it would be misleading to actually state the number because that is the question as to where do you draw the line and then if you want the number of companies that we've discussed our products with, it's a very big number, if you want the number that where the current discussions are at a certain stage, then of course it gets -- some of these companies are at earlier stages. And from the stand point of sort of a first mover advantage, I don't think that – we are talking with major companies and this is an area of high, a very high interest for them but they look at this and then obviously in a very professional and careful way. You can imagine the number of product opportunities they see both internally and externally and – so at this stage, they are just going through their due diligence. Anat, you want to add more?
Anat Cohen-Dayag
I think that with respect to your last comment about priority I would like to add that we are not conducting the discussions based on priority. This is more has to do with how much there is the fit, there's an expertise that is associated with this type of per candidate and to make sure that we increase the probability of success of our molecules in the clinic. Either in clinical trials or later and all these parameters has to do with setting priorities. And also one other thing that we take into consideration is how much the partner will have an interest for us to participate in early stages of development and increase probability of success.
Brett Reiss – Janney Montgomery Scott
Can I ask another one or you want me to get back in queue?
Martin Gerstel
That's okay. One more you got.
Brett Reiss – Janney Montgomery Scott
Okay. This operative phase in your press release clear and positive feedback we are receiving from major pharmaceutical companies. Pretend I am your six year old grandson. Can you describe to your six year grandson what – can you be a little descriptive what are those conversations revolve around? What are they asking you? What are you saying to them?
Anat Cohen-Dayag
I think that it will be a mistake for us to dive into the details of discussions that we are having but of course we are relating to their impression with respect to our discovery capabilities that have led to these discoveries of product candidates and to the potential value of the product candidates themselves but I think that we can't get into the details of discussion.
Martin Gerstel
One aspect of this that I have found interesting is that in earlier discussions with pharmaceutical companies before we had the pipeline and we are attempting to get them to work with us with respect to our capabilities. The questions always related to them trying to understand our – the way we did things, how do we do the predictive discovery. Even to the extent of some of them even wanting to have access to the certain of the algorithms that we utilize, which of course we would not share with them. What is totally different now is when they see these results, the question as to how do we do things goes out the window. The results speak for themselves, there's absolutely no reason now for any pharmaceutical company to have to make a judgment as to whether or not our predictive biology works. The evidence is 100% clear, we've used -- in areas of high interest for them in a tiny fraction of the time and money that has been committed to this field by others.
Orders of magnitude less by us than other people, we have made discoveries that they have not been able to make and not only that but have now taken those discoveries into the exact same disease animal models that they rely on in order to evaluate whether or not their product candidates are worthy of further development and are not referred to the incredible level of success we have had in these meetings. So I would say following up on whether or not that one, there is an enormous appreciation for the uniqueness and the accuracy and the power of what we've accomplished here in the case the infrastructure that now exists here and there is a very strong interest, and it varies company by company, indication by indication, molecule by molecule. So it's in many different areas but there's a significant amount of interest out there.
Brett Reiss – Janney Montgomery Scott
Has any company…
Martin Gerstel
We'll, that's your third.
Brett Reiss – Janney Montgomery Scott
Okay. I'll drop back.
(Operator instructions). Please stand by while we pool for more questions. The next question is from Klaus Von Stutterheim – Deutsche Bank. Please go ahead.
Klaus Von Stutterheim – Deutsche Bank
Can you talk about the expected burn rate for the next 12 to 24 months and possible sources of funding?
Martin Gerstel
Well, as Dikla mentioned, we had capital available, available sources of capital that takes us we'll into 2014 given our current burn rate. And our burn rate is very much under our control in view of the fact that if we were to increase it would be with doing more tests out of – not in the company but with providers and whatever. So we don't see any immediate crisis in any way. Of course companies like ours should always have substantial cash on board.
Dikla Czaczkes Axselbrad
I would add to that as you probably can imagine we are now in the process of budgeting for 2013 and this will of course be approved. The budget will of course be presented with the board and approved by them hopefully. And we'll probably give specific guidelines at the end of the year but as of now we do not see dramatic change from this year level of expenses.
Klaus Von Stutterheim – Deutsche Bank
Many thanks.
The next question is a follow up question from Brett Reiss, from Janney Montgomery Scott. Please go ahead.
Brett Reiss – Janney Montgomery Scott
Hello again. Had the discussions with any particular Pharma company gotten to the point where they have specifically said to you what more they need from you before they would be willing to commit to material financial deal where there's material consideration that would be extended to the company?
Martin Gerstel
I don't think we should get into this discussion but the only thing I would say is that the discussions really don't kind of don't go there in that direction. They do their due diligence, they request information, we provide it to them. So but I guess let me just drop it at that. We cannot – even if we wanted to, there's not very little that we could tell you that would assist you to give you what you are looking for that is because we can't. No one can really know when the first deal is going to be signed. There's just no way – these are complicated agreements and the complications get involve in its intellectual property and licensing rights and all kinds of due diligence requirements, things that -- they are very complicated agreements. So they can take some fairly extensive time just to draft the arrangements.
Brett Reiss – Janney Montgomery Scott
Okay. Thank you.
There are no further questions at this time. Before I ask Dr. Cohen-Dayag to go ahead into our closing statements, I would like to remind participants that a replay of this call is scheduled to begin in two hours for a period of 72 hours. In the U.S. please call 188-782-4291. In Israel, please call 03-925-5904. Internationally please call 972-3-925-5904. Dr. Cohen-Dayag, please go ahead with your concluding statement.
Anat Cohen-Dayag
Yes, thank you. Before assuming the CEO position at Compugen in early 2010, I had been head of our R&D activities and therefore had a good appreciation of the capabilities and enormous potential that had been created by our exceptional team of scientists. However, the proof of this potential at that time was largely in the form of novel molecules demonstrative the discovery capabilities of the individual platforms but not necessarily molecules targeting clear un-mathematical needs with superior properties to those already known. These discoveries were critical in validating the predictive capabilities but not very useful when trying to convince others that Compugen's discovery infrastructure could be focused to specific areas of interest and lead to popular candidates with potential superiority.
Therefore, my first major decision as the CEO was to undertake our initial market directed discovery program utilizing all of our integrated capabilities not just in individual discovery platform in an area of high industry interest and direct them towards the discovery of superior targeted medicine. As we have discussed, we chose the very complex fields of Oncology and Immunology, and within these fields our first area was the B7/CD28 immune check point family of proteins. Since this protein family is of immense interest in the industry with applications in both of our fields of focus. Furthermore, new family members had proven extremely difficult to find using conventional experimental basic discovery effort. We are very pleased to be now sharing the exceptional results we have achieved in this first proper discovery efforts with leading companies in our industry.
The response we are receiving is very satisfying not just with respect to the medical and commercial potential of our product candidate but with respect to validation of the power and uniqueness of the predictive discovery infrastructure that we have created and continued to enhance. With this in mind as we now approach the commercialization stage in the form of collaboration agreement for the first wave for our product candidate from our pipe end program, we want to particularly thank our long term shareholders who have supported us through this long but value creating journey. Thank you and we look forward to sharing with you further development in the near future.
Thank you. This concludes the Compugen Limited third quarter 2012 financial results conference call. Thank you for your participation. You may go ahead and disconnect.
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text:
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text:
"In this social media/social economy era, we are seeing tremendous renewed interest in the art, science, design and business of collaboration. If we think of information as raw material for innovative collaboration and network technology as connective tissue, we can think of process models as frameworks for disciplined orchestration.� Humantific Team
Humantific for OPEN Innovation Consortium
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text:
Anthony Ashford
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Boarding a bus by Roberts Hawaii, your tour will stop at popular sights such as Hookipa Lookout, where surfers slash through breaking waves to the backdrop of the West Maui Mountains. At the halfway point on the journey to Hana, you'll also stop at Keanae Lookout for a panoramic view of the shoreline, where local families farm fields of taro as their ancestors have done for centuries.
Stop at popular Waianapanapa Sate Park—home to the black sand beach—before continuing on towards Hana Bay and the town of Hana itself. You'll also pass numerous waterfalls that are easily visible from the road, including Waikani Falls, Wailua Falls, and smaller ones in between.
April 2016
This as an amazing tour and our guide Tai was fantastic. He was very knowledgable and took us to more non-tourist stops. I learned so much about the island, it's history, and the plants and fauna. I would highly recommend this tour. It was much better than trying to drive it ourselves.
November 2015
Great tour, knowledgeable tour guide. We saw things we would not have seen if we did this tour on our own. The many waterfalls, rainforest and beach scenery was beautiful. A tour you must do! Very pleased with this tour.
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Awesome tour, ours was the best tour guide, and best driver on the road to Hana. A must-do if one wants to truly enjoy and fear the drive down the cliff road to Hana and back.
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December 2013
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Great Tour and the driver/guide was excellent
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"Everything was great. We did not know we would have to pay $10per night for parking. Breakfast was very good."
A Traveller, Oct 2016, US
27 people looked at this hotel in the last hour
Most recent review
"Delightful historic home converted to an inn. Our room was comfortable, although small. It was well-maintained and very clean. Large continental breakfast was good and plentiful, and nicely presented in a window-filled breakfast room. The only negative was the parking, which is limited."
A Traveller, Oct 2016, US
10 people looked at this hotel in the last hour
Most recent review
"Homey feeling to the Victorian-style inn. The studio size room was just right with clean bathroom and king size bed. It was a nice stay for a short getaway. Great location-driving distance to New Providence and East Hanover. The management is great. "
A Traveller, Sep 2016, US
Hotels within 5 miles of Summit
30 people looked at this hotel in the last hour
Most recent review
"Great hotel right off the highway about 30 mins from EWR and close to a lot of malls and restaurants"
A Traveller, Sep 2016, US
17 people looked at this hotel in the last hour
15 people looked at this hotel in the last hour
Most recent review
"We were there to visit where we had lived before. This location was near to everything we were visiting. The room was always clean and the help at the front desk were polite"
A Traveller, Sep 2016, US
15 people looked at this hotel in the last hour
Most recent review
"stayed one night - arrived late & staff was very nice & helpful. Staff rates an A both that night and the next morning."
A Traveller, May 2016, US
- Hilton Garden Inn SpringfieldNo Guest Reviews yet
7 people looked at this hotel in the last hour
- Embassy Suites by Hilton Berkeley HeightsNo Guest Reviews yet
6 people looked at this hotel in the last hour
- Churchill At Avalon At Florham ParkNo Guest Reviews yet
4 people looked at this hotel in the last hour
Best hotels in Summit
Summit overviewSummit is special for its gardens and sports, and known for its historical sites and shops. You're sure to enjoy all of the coffee and bar options. Learn about local heritage at popular landmarks in the area like Statue of Liberty and Ellis Island. Make plans to visit the popular Montclair State University and Ellis Island Immigration Museum. A family- and business-friendly area, Summit also has something for everyone.
Where to stay in SummitSummit offers a wealth of accommodation options for business and leisure travelers alike. There are 1116 hotels in the Summit area and you can shop as many as 600 deals for rooms on Hotels.com, some with discounts of up to 60%.
- • 154 2-star hotels with an average price of $56 per night
- • 398 3-star hotels with an average price of $90 per night
- • 401 4-star hotels with an average price of $111 per night
- • 96 5-star hotels with an average price of $194 per night
Here are the top hotels based on 502729 user reviews of Summit hotels:
- • The Summit DeBary Inn
- • Turkey Hill Inn
- • The Grand Summit Hotel
How to get to SummitFly in to Morristown, NJ (MMU-Morristown Municipal), 6.3 mi (10.2 km) from downtown Summit. Newark, NJ (EWR-Liberty Intl.) is the next closest major airport, 10 mi (16.1 km) away.
Train stations include:
- • Summit Station
- • Summit New Providence Station
What to see around SummitFun activities include attractions such as:
- • Atlantic Health Training Center
- • Alumni Stadium
- • Mennen Sports Arena
- • Prudential Center
- • Bears and Eagles Riverfront Stadium
- • Bowcraft Amusement Park
- • Florham Park Roller Rink
- • Turtle Back Zoo
- • The Funplex
- • The Raptor Trust
- • Mall at Short Hills
- • Livingston Mall
- • Jersey Gardens Outlet Mall
- • Woodbridge Center
- • Middlesex Mall
- • Montclair State University
- • Statue of Liberty
- • Ellis Island Immigration Museum
- • Ellis Island
- • Rutgers University
When to visit SummitWondering when's the best time to visit? Here are seasonal norms to help you plan your trip:
Seasonal temperature averages
- • January-March: 56°F day, 19°F night
- • April-June: 84°F day, 33°F night
- • July-September: 86°F day, 47°F night
- • October-December: 71°F day, 20°F night
- • January-March: 11.3 inches
- • April-June: 13.1 inches
- • July-September: 13.3 inches
- • October-December: 12.8 inches


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A stay at THE ONE Executive Suites places you in the heart of Shanghai, walking distance from Taobao Market and Shanghai Natural History Museum. This 4.5-star aparthotel is close to Jing An Temple and The Bund.
Make yourself at home in one of the 244 air-conditioned rooms featuring kitchenettes with refrigerators and microwaves. LCD televisions with satellite programming provide entertainment, while complimentary wireless Internet access keeps you connected. Conveniences include phones, as well as laptop-compatible safes and desks.
Enjoy a range of recreational amenities, including an outdoor pool, an indoor pool, and a sauna. This aparthotel also features complimentary wireless Internet access, concierge services, and a hair salon.
Grab a bite at one of the aparthotel's 2 restaurants, or stay in and take advantage of 24-hour room service. Quench your thirst with your favorite drink at a bar/lounge. Buffet breakfasts are available for a fee.
Business, Other Amenities
Featured amenities include a business center, limo/town car service, and dry cleaning/laundry services.


text:
hey mad_mask
a template is a set of sorce files like utils.h and winbase.cpp
that teej has set up for us so we can focus on programming the actually guts of the game "game_main.cpp" a template is just a base for you to work off of so you dont have to worry about programming all the other stuff cuz its already taken care of as part of the template!
03.02 - Language Topic Requests
Started by Apr 10 2001 04:03 AM,
41 replies to this topic
#41 Members - Reputation: 122
Posted 03 August 2001 - 04:12 PM
#42 Members - Reputation: 122
Posted 22 December 2002 - 12:17 PM
I''m new to the site and have just read about the c++ language. Where would I go to learn it? I might already know some. I''ve been using video games and computers for about 20 year. I''m eager to learn so I can begin the development of my game and possible help others.
Todd Durden
Todd Durden


text:
South Carolina Highway Patrol is investigating a deadly wreck in Horry County.
It happened Wednesday around 3 a.m. on Shell Road at Highway 905 near Conway, according to Highway Patrol's website.
One vehicle was involved.
The victim is a 63-year-old Samuel E. Ellis of Conway, according to Horry County Deputy Coroner Tony Hendrick.


text:
SummaryInstitutional challenges require an institutional response. How the institution designs its response will in large part determine its success, and whether it is sustainable. Will it suffice to meet the challenge it faces, and then fade away? A truly adaptive, learning institution will acculturate change at a deep level so that the corrective processes continue and the challenge doesn't evolve to re-emerge yet again.
How do we learn and acculturate new technologies and processes? One way is to encourage our organization's communities of practice to adapt to challenges. By watching our communities of practice respond to challenges, we can also identify the leadership that emerges. The emergent leadership, given support, opportunity and coaching, will naturally use their passion and influence to share their knowledge within their communities, thereby speeding adoption of technology and process change, and increasing capability and capacity within the institution.
This article is a case study of Penn State's ongoing response to the complaint filed against it regarding the accessibility of its websites, applications and services. Our focus is: how communities of practice change in response to institutional challenges, the observation that the leadership to address challenges emerges from within these communities, and that the social learning processes that allow communities of practice to adapt to new challenges also support the sustainability of new technology and practice.


text:
The stupid moron was so drunk he went the wrong way down the expressway, when
he struck a limo heading home from a wedding reception, killing the driver, and
a 7 year old flower girl. His BAC was 3 times the legal limit, and after re-watching the video link in the story, I will correct myself to please the powers that be, and say that the girl was indeed the one decapitated in the accident.
18 to life isn't enough. Lock him away for life. Period.


text:
Shambolic Fat Lip Pencil
This product is currently sold out.
What's not to like? It's glossy, shimmery, and perfect for day or night.
The smooth buttery texture coats lips in a stunning glossy color and
comes in a handy jumbo pencil that doesn't need a sharpener!
Artwork done by Elena Kulikova
Ingredients: Ricinus Communis (castor) Seed Oil, Ethylhexyl Hydroxystearate Microcrystalline Wax, Paraffin, Vegetable Oil, Cera Alba, Euphorbia Cerifera (candelilla) Wax, Copernicia Cerifera (carnauba) Wax, Isostearyl Palmitate, Cetyl Alcohol, Vitamin E, Sucrose Acetate Isobuterate, Phenoxyethanol, Mentha Piperita. May Contain: Lron Oxides (cl 77491, Cl 77492, Cl 77499), Titanium Dioxide, Ultramarines Mica


text:
SHOUT is the "Mod Musical" that brings back the msashing sounds that made England swing in the 1960s.
The stage production will be held at The Arts Center of Cannon County on 1424 John Bragg Highway in Woodbury. Show times are Aug. 15, 16, 22, 23, 29 and 30 at 7:30 p.m. and August 17 and 24 at 2 p.m. Admission is $15 for adults, $13 for students and seniors. Form more information, call (615) 563-2787 or 1-800-235-9073, or visit. www.artscenterofcc.com
Set in London, SHOUT travels in time from 1960-1970 following five women during the dawning liberation of women. Rachel Jentzsch Cole (orange girl), Beth Daniels (red girl), Leah Ray (blue girl), Hayley Orozco (yellow girl) and Erica Paige Melton (green girl) are featured in an ensemble cast of English and American girls who redefine themselves in the face of changing attitudes about gender, just as Dusty Springfield, Petula Clark, Cilla Black, and Lulu were becoming independent women with major careers. This show celebrates those changes through the unforgettable music of the time, the soundtrack of their lives.
SHOUT features terrific new arrangements of such classic tunes as "To Sir With Love," "Wishin' and Hopin'," "Downtown," "Georgy Girl," "I Only Wanna Be With You," "Son of a Preacher Man," and "Goldfinger." With a shimmy and a shake, the songs are tied together by hilarious sound bites from the period – from 60's advertisements for anything and everything, to lonely hearts letters answered by an advice columnist who thinks every problem can be solved with a "fetching new hairstyle and a new shade of lipstick."
This production is directed by Abbey Kairdolf with music direction by Stephen Burnette, choreography by Danielle Davula and produced by Carol Reed.
SHOUT! The Mod Musical is sponsored by First Bank and is part of the 2014 Arts Center Subscriber Series. The Arts Center is located on 1424 John Bragg Highway, just west of the town of Woodbury, approximately 20 minutes from Murfreesboro, Manchester, and McMinnville and one hour southeast of Nashville. Box office hours are 10:00a.m. to 4:00p.m., Monday through Saturday. "The Blue Porch @ Arts Center" restaurant is open before all performances.
Founded in 1990, the award-winning Arts Center of Cannon County is a unique model for rural arts organizations. Situated in an under-served rural area in a town of 2,000 and a county of 12,000, The Arts Center annually attracts more than 40,000 visitors from a region covering over a 100-mile radius. Drawing on the blue-collar roots of its community, the organization focuses on self-sufficiency, fiscal responsibility and social entrepreneurship. The Arts Center is partially funded by the Tennessee Arts Commission, Southern Arts Federation and the National Endowment for the Arts.
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text:
The Medium Banner in House Check and Leather
Item 40035471
$1,895 $1,895
Use the Size Guide to choose the best fit for your measurements.
In this window, you can find out the shipping and returns options for the selected item or contact Customer Service for further assistance
- The Banner in English-woven House check with a perforated leather stripe overlay. Made in Italy, the bag is inspired by equestrian styles from the Burberry Heritage Archive.
- 34 x 16 x 25cm/13.4 x 6.3 x 9.8in
- Min. shoulder strap length: 77.5cm/30.5in
- Max. shoulder strap length: 92.5cm/36.4in
- 100% cotton with calf leather trim
- Lining: 100% cotton
- One central zip compartment
- One interior zip pocket, two interior pouch pockets
- Detachable leather shoulder strap
- Double magnetic press-stud closure, press-stud clip on handles
- Hand-painted edges
- Polished metal hardware
- Raised Burberry lettering at front
- Made in Italy
Recommended Products


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Traveling deep into the West Bank, far from the roads of the masters, Palestinians struggle to get home and to forget the times.0 comments
Amira Hass is the Haaretz correspondent for the Occupied Territories.
Born in Jerusalem in 1956, Hass joined Haaretz in 1989, and has been in her current position since 1993. As the correspondent for the territories, she spent three years living in Gaza, which served of the basis for her widely acclaimed book, "Drinking the Sea at Gaza." She has lived in the West Bank city of Ramallah since 1997.
Hass is also the author of two other books, both of which are compilations of her articles.


text:
- Member Services
- Fastcase
- Member Search
- TBA Member Benefits
- Government Affairs Update
- Joblink
- Law Practice Management
- Legal Links
- Local Rules of Court
- Mediation
- Opinion Search
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- Update Information
- Programs
- Corporate Counsel Pro Bono Initiative
- Government Affairs Update
- Law Student Outreach
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- Legal Assistance Volunteers For Patent Applicants
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- ABA Resource Committee
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- Access to Justice Committee
- CLE Committee
- Committee on Racial and Ethnic Diversity
- Committee on the Judiciary
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- Governmental Affairs Committee
- Leadership Law
- Legal-Medical Relations Committee
- Long Range Planning
- Mentoring Committee
- Public Education Committee
- Tennessee Bar Journal Editorial Board
- Unauthorized Practice of Law
- Special Committee on Evolving Legal Markets
- Special Committee on Law Practice by Foreign Lawyers
- Leadership Law Alumni
- Sections
- Tennessee Legal Organizations
- Young Lawyers Division
- YLD Fellows
- Committees
- Publications
- Access to Justice
- Access to Justice Committee
- Attorney Web Pages
- Celebrate Pro Bono Month 2016
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- Hometown Support: Legal Help For Our Military
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Judge Franks Honored for Service to Judiciary
Members of the judiciary and legal profession honored Tennessee Court of Appeals Presiding Judge Herschel P. Franks for his years of service to the state judiciary during a recognition ceremony last Friday. Among the many tributes, Supreme Court Justice Sharon G. Lee presented a plaque to Franks, who is retiring at the end of the year after 42 years of service. See photos from the event on the AOC site
In related news, a portrait unveiling in Franks' honor will be held in the courtroom of the Tennessee Supreme Court in Knoxville on Dec. 3 at 10:30 a.m. A reception will follow.| TBA Law Blog


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Domes 'Holiday Show' opening announced
"Let It Snow" is the theme of the Mitchell Park Domes "2012 Holiday Show," park officials have announced, and that theme will be carried out with figures of snow kids sledding and sleighing among the poinsettias.
A 40'foot white pine tree decorated with snowflakes will be the centerpiece. »Read Full Article
Milwaukee Art Museum will be free this weekend
The Milwaukee Art Museum's admission will be free on Saturday and Sunday from 10 a.m. to 5 p.m. This is to mark the opening of "30 Americans," a multi-generational art exhibit featuring the work of African American artists.
Many of the artists in the exhibit address issues of race and cultural identity in very direct ways, and the show is one of the first in the museum's featured exhibition space to explore such issues so directly. The museum has also placed "Wisconsin 30" an exhibit of 30 African American artists from the state on view. »Read Full Blog Post
New DVDs for release June 18
Milwaukee movies off the gridn June 14-20
Bike and a movie
The Milwaukee Bike-In Movie Series returns Friday with the 1989 John Candy comedy "Uncle Buck." »Read Full Article
Outdoor films return to lakefront
The Fish Fry and a Flick outdoor movie series returns to the lakefront Aug. 30 with a showing of the Marvel superhero action film "The Avengers."
The series will also show two adult-themed films, "Ted" on Sept. 6 and "Django Unchained" on Sept. 13. »Read Full Article
Kohl's hosts style session with Lauren Conrad for three Children's Hospital teens
Lauren Conrad, fashion designer, style expert and best-selling author, teamed up with Kohl's to treat three teens from Children's Hospital of Wisconsin to a celebrity styling session Wednesday night in Milwaukee.
The event took place prior to Conrad's book signing for the launch of Infamous: A Fame Game Novel, the finale to her The Fame Game series, at Boswell Book Co. »Read Full Blog Post(1)


text:
full size
Product Details
Few shirts age better than an oxford. The frays, the fades—these are the kinds of details we love. We designed this version with a contrast pocket and collar to make it a little different from the rest of the shirts in your closet.
Size & Fit Details
Slim vintage oxford shirt with contrast trim
Rated 5 out of 5 by 1 reviewer.
Rated 5 out of 5 by Malgenius Great Summer Shirt This is a great shirt to stay cool, and I love the contrasting collar and pocket. Just an overall great design! July 6, 2014
1-1 of 1


text:
CodePlexProject Hosting for Open Source Software
Please make this your first forum for discussing FacebookPSModule.
Mar 12
2:48 AM(3 posts)
first post: reabarca78 wrote: I was using the lastest version of the Facebook PS Module and I wa...
Dec 17, 2015
3:39 PM(11 posts)
first post: jonn_msft wrote: I just saw a notice on Twitter of changes to FacebookPSModule which...
Jul 16, 2015
3:14 PM(1 post)
first post: nicklean wrote: New-FBConnection logs me in successfully. Get-FBConnection fetches ...
Apr 28, 2015
5:09 PM(2 posts)
first post: kiquenet wrote: is it possible now with latest API ?
I use C# and Powershell.
5:08 PM(2 posts)
first post: tondam wrote: I was extracting the total number of "Likes" and note it stops at 2...
Jan 2, 2015
11:02 PM(2 posts)
first post: allyzon21 wrote: Hello Jon,
I can't discover New-FBPost after I installed the lates...
Dec 11, 2014
6:48 PM(10 posts)
first post: EricTremblay wrote: I figured out how to use the FB Module and up to this point all is ...
Aug 24, 2014
4:23 AM(2 posts)
first post: fabiopjr wrote: I got a list of all users in a group using (get-fbmember 123456789,...
Mar 30, 2014
4:32 PM(2 posts)
first post: iamrk wrote: Is it possible to post on any friends wall using this code?
and i ...
Feb 24, 2014
12:14 AM(2 posts)
first post: cveira wrote: Hi Jon,
Do you have any plans to support Facebook Insights? Would...
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Keep up with what's going on in this project's discussions


text:
Sok Yee, Student
3D Light Shades
Director Stylist Charles: Go for icy grey highlight interspersed with slightly darker cool ash tones to give the overall appearance of being lights and bright. Let these 3D high-shine shades light the way to your best hair ever.
We support your transformation. 76Style, Your Way!


text:
Claims Not Valid
Editor, News-Register:
Regarding the June 2 article "Exotic Animal Owners In Ohio Appeal Restrictions." The First and Fifth Amendments were ratified Dec. 15, 1791. Even if authors had supernatural knowledge of all seven continents and the variety of animals inhabiting them, I doubt they would have dealt with subject of exotic pets owned by American citizens. Owners and their legal representatives should review the Constitution and its Amendments. Afterward they would realize the documents apply to all people, not animals!
Article claims proposed laws would violate First Amendment rights of owners "… by limiting their freedom of association …" Amendment states: "Congress shall make no law … abridging … the right of the people peaceably to assemble …" This is a very direct statement, easy to understand, stating Constitution/Amendments are for people.
The Fifth Amendment contains a statement that exotic pet owners and their legal representatives think is a gotcha, namely: "nor be deprived of … property without due process of law; nor shall private property be taken for public use without just compensation." They feel requiring the purchase and implantation of a micro-chip in an exotic pet represents an exorbitant expense, tantamount to "taking private property …"! Conveniently, the typical cost of this micro-chip is not in article, only that the cost is exorbitant.
Exorbitant? Whoa, there, people! A Smart Phone only costs $300-$400! I can't believe the cost of a micro-chip is so exorbitant owners of a $5,000-$10,000 pet can't afford one.
Exotic pet ownership is in that age-old category: "If you have to ask the price, you can't afford it!" I know owners are burdened with some deprivations already and can't afford: driving cars due to driver's license fee; buying cars due to sales taxes; buying gas for previously owned cars due to sales and road use taxes; smoking due to sales taxes; vacations due to cost of their exotic pet and its related expenses. But that's life!
Exotic pets belong in their exotic natural environments, not in unfit makeshift cages or holding pens, thrown together with little concern for animals' welfare.
James Wisialowski


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8-inch cake made for gf several years ago - don't remember flavor - probably is coconut and pecan filling cooked in microwave . Royal icing flowers left over from class. Color flow fence before having any classes in it - my first -and I definitely had lots to learn! Rope edging.
CakeCentral.com is the world's largest cake community for cake decorating professionals and enthusiasts.
(if this is a private computer)
Yes please, register now!


text:
See attached screens.
These aren't screenshots from the live app for obvious reasons (all FPO data).
We designed and developed this B2B system for a client...
December 13, 2011
November 27, 2010
Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
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