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|Download : Graphics : Catalog Gallery : Enot is a cool photo-cataloging software
Enot is a photo-cataloging software that ensures fast search of photos - Windows Shareware $19.95. Enot is a photo-cataloging software designed to avoid most problems of the existing cataloging solutions and ensure fast and simple search of certain photos within a large photo collection. Enot is an external photo database and search engine that integrates with your favorite photo viewer. It works with almost any photo viewer that supports command line (ACDSee 5 is highly recommended). The following is the list of main features introduced by Enot: * Open-format database that can be exported to XML/HTML/TEXT formats.
Acritum Photo Enote 1.03.1 21-Feb-07 English 771 KB
* Bi-directional integration with virtually any modern photo viewer. * Simplicity of photo migration and the possibility to automatically reassign database records to moved or renamed photos. * In no circumstances your photos will be modified by Enot, all data is kept in external databases only. * Unlimited number of databases in one computer. * Reasonable differentiation of information by fields makes the search fast and relevant. * Database fileds can be imported from EXIF and IPTC metadata of the photos even in batch process. * Obsolete idea of categories gave way to 3D-groups. * Each photo can be assessed by two parameters: impression and quality. * Batch process allows you to update certain database fields for several thousands of photos within just a few seconds. * Advanced search methods such as "searching by season" or "looking for photos taken in a certain distance from the place where the sample photo was taken" makes the search possibilities really ultimate. Try it free of charge - there are no time limitations!
|Acdsee Viewer Digital Picture Graphic. Image Database Manager Search Jpg Slideshow Cataloging Ensures Fast.
| Acritum Photo Enote


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What is high blood pressure?
As your heart pumps blood to the different parts of your body, the blood pushes against the walls of your blood vessels and arteries. The force that it exerts is what doctors call blood pressure.
The more blood your heart pumps, and the narrower your arteries, the greater your blood pressure will be. When it becomes higher than the level recommended for good health, it is called high blood pressure or hypertension. BENICAR and BENICAR HCT have been proven to help lower blood pressure. BENICAR HCT is not indicated as the first medication to use for treatment of high blood pressure. Talk to your doctor to see if BENICAR or BENICAR HCT may be right for you.
What causes high blood pressure?
High blood pressure often has no direct cause. However, certain risk factors may increase your chances of developing it. Some, such as age, gender, race, and family history, cannot be controlled. Fortunately, you can help control many of the others.
Risk factors you CAN control
Losing even a small amount of weight can help you lower your blood pressure.2
Lack of physical activity
Regular physical activity can help you lower your blood pressure and keep your weight under control.
Tobacco use
Smoking or chewing tobacco can raise blood pressure. If you smoke, quit.
A high salt (sodium) diet
A diet low in sodium has been shown to help lower blood pressure.3
Alcohol use
Too much may raise your blood pressure.
Stress can raise blood pressure temporarily and may lead to overeating, and tobacco or alcohol use. There are techniques to help reduce it.
Certain conditions
High cholesterol, diabetes, kidney disease, and sleep apnea may increase your risk of high blood pressure. Talk to your doctor if you have these.
Some medications
Decongestants, birth control pills, and certain pain relievers and prescription drugs can raise blood pressure. Talk to your doctor before taking them.
Did you know?
Selected Important Safety Information
Do not take BENICAR or BENICAR HCT if you:
- Take a medicine that contains aliskiren and you have diabetes or kidney problems
Do not take BENICAR HCT if you:
- Have less urine than normal or if you cannot urinate
- Are allergic to other sulfonamide type medicines
- Have severe kidney disease
For important safety information, please see below.

subset: commoncrawl


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Ben Littlechild
Ben Littlechild Poems
- A Stranger Called Love You see me on the street A man so ...
- Beauty In My Eyes Your beauty is like a summer rain And a ...
- Distant Love She lives so far away, On a shore where a ...
- Inbox Torment Love left me in an email The noise of new ...
- Night Cycling Through dark streets I ride where cones of ...
- Love Is Like A Delicate Flower Love is like a delicate ...
- Caesar When the day is ended and done I come home to loved ...
Born and raised in Cambridge, the inspiration of the area, (Brooke, Tennyson, Byron, Chaucer) led me to explore the world through words, and I tend to find myself writing about love, nature, and living in cambridge. Hope you like some of what I have written! more »
Click here to add this poet to your My Favorite Poets.
Comments about Ben Littlechild
A Stranger Called Love
You see me on the street
A man so plain you will never meet
He that seems so quiet and reserved.
Yet love never found him, love that he deserved.
That man, he that hangs his head and appears wise.
Love has outwitted him, and now its his despise
That makes him just another lonely guy
For love to him is a stranger on the street,
One that never stops to meet and greet.
PoemHunter.com Updates
Check out
Classic Poets
Footsteps of Angels
Henry Wadsworth Longfellow
A Song About Myself
John Keats
A Very Short Song
Dorothy Parker


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I think you were hit with a combo of things. One, I find that feeling especially good about myself, like weighing less than the husband or hitting a new low, can set me off into bingeing as much as bad feelings. Two, You watched others eat junk and resisted, but your mind may have told you that you deprived yourself. Three, it is possible that hormones were at play or your body was seeking something to fulfill a nutritional deficiency.
Number three (nutritional deficiency) is a friend's theory that I always thought was nonsense, but I have made some nutritional changes that have lessened the physical cravings.
It was a moment in time. If you can get past it and learn from it, you will be fine.
Primal since 9/24/2010"Our greatest foes, and whom we must chiefly combat, are within." Miguel de Cervantes
Created by MyFitnessPal.com - Free Weight Loss ToolsMFP username: MDAPebbles67
*weeping* for you, with you and for me!! (((HUgs))) for both of us.. As I read your entry acknowleding your eating frenzy I was swept up and away in so many exact feelings and moments even just last week. I so *felt* every urge, emotiona and desperation.. Sabine you are not alone!!! You are NOT alone!!! I find myself stuffed beyond capacity and still seeking more sometimes. I always try to stick within the eating guidelines I mean how else can I justify the binge?? So I may start with a handful of macadamians (a dangerous start) which leads to ALL of the macadamias, Then it's a bite of the leftover meat which leads to ALL of the leftover meat, then it's maybe a boil egg which leads to MORE eggs.. And Gawd forbid there is cheese or HWC or other nuts or nut butters anywhere around... O M G.. What just happened I ask myself??? You are NOT alone *leaving to ponder this affliction*
Hi Sabine, I'm new around here and I thought I would just jump in and tell you that I have been reading your journal and find it really inspiring and downright moving. I relate to so many of the situations and emotions that you have experienced.
The cravings/nutrition/hormone thing is something I am really interested in. I remember when my sister was pregnant, she would eat ice nonstop. Would sit around with a cup of crushed ice and eat it with a spoon. Turned out she was extremely anemic and has struggled with iron deficiency ever since. She can tell when it is really low because she craves ice!
My Primal Journal: http://www.marksdailyapple.com/forum/thread53052.html
"Freedom from fear" could be said to sum up the whole philosophy of human rights. - Dag Hammarskjold
Sabine, I agree with all that has been said already. Today is a new day, so just hop back on the wagon and we'll continue our ride!
My Journal: Candy in Primal Wonderland
My Blog: Candy in Wonderland
Goal for 2012: keep weight steady (+/- 74 kg): check
Goal for 2013: lose 10 kg and keep new weight (+/- 65 kg)
I woke up feeling good, no 'hangover' from my binge. I waited until I was hungry, drinking plenty of water along the way.
(Don't know you y'all feel about drinking water. It is almost the only thing I do drink, no soda, juices, rarely milk, rarely teas. No coffee- never got the habit- and although I used to drink frappacinos, can they really be called coffee? I was definitely drinking them for the sugar, not the coffee taste. I just put up with that. Anyhow, back to water. I can tell a difference in how I feel from when i am hydrated or not. I usually drink about 6-8 glasses a day, and feel best when I am at least 10. Strangely, I do have to work to keep at that level. You would think, if you feel good drinking 12, it would be easy, but since when is doing what is good for you easy?)
I didn't have the antsy post-sugar feeling I often get, so I am prepared to have it today. I will deal with it, and not be caught off guard.
Here's what I ate:
Up at 5:45
1:45 wreck salad from potbelly:
lettuce, 4 cherry tomatoes, cukes
roast beef, ham, turkey
swiss and blue cheese
hard-boiled egg
viniagrette(some kind of sweet in it, but not unbearably so)
6:00 much cod fried in
butter with
lemon juice and
cream to deglaze the pan
broccoli with olives, roasted peppers, and blue cheese
Water: 12 glasses
Bed at 8:00, up at 10:00 for child transport, back to bed at 11:00
There was no activity to speak of, besides some aggravating trailing after uncooperative people in the morning. Stress with that, but what can you do. (Ummm, your affirmations, I guess, but did I? No, I just fumed. Oops.)
I weighed and measured this morning, but due to the very recent binge, I am not recording the numbers. Even the ones that are down. I'll check back in at the end of the month with that.
Today there will be more trailing. Hopefully, the people will be more cooperative. I will plan to do my relaxing affirmations, controlling what I can: my attitude.
One of my favorite quotes:
It is not the mountain we conquer, but ourselves. ~Sir Edmund Hillary
Pebbles- too true. But why does it have to be a triple threat?!? I feel I am just learning to deal with one thing at a time, then...WHAM! I think the thing that hot the hardest was feeling good about myself. And the realization of that, is another blow. How can I be in such a bad place that I feel I can't feel good about myself? That is so messed up. I'll be glad when I am past it.
Longing- thanks for your sympathy. That's a great thing about these journals: people who are supportive and interested in what others are going through.
Siobhan- thanks for stopping by. An interesting (to me, at least) thing: when I first saw your journal, I checked it out because Siobhan was a name we considered for our daughter. I'm glad you are finding my journal useful. I get so much out of other people's journals, and it is nice to think I might be returning the favor.
Candy and PrimalCajun- it is a great wagon with you guys aboard.
We evolved as diurnal animals, yet how many of us go to bed when it gets dark outside? Or even within a couple hours of it?
Since I began going to bed regularly at 9:00, I have felt so much better. I look forward to staying up a little longer as the days lengthen in summer, but I will still be going to bed at a reasonable hour. And my definition of reasonable has gotten narrower and narrower.
Being primal there are things we DO and things we REFRAIN from doing. Yes to plenty of veges and grass-fed meats. Refrain from sugars and grains. Yes to lots of slow walking. Refrain from running ten miles every day(okay, granted, that one is super easy for me. But some people DO like to run.)
Some find it hard to say yes to enough sleep, AND to refrain from staying up late, though they are two sides of the same coin. They love their socializing, working, surfing. They think they can magically have it all: stay up late and still get enough sleep. But unless you are living in a completely artificial environment (which has its own difficulties) your body WILL notice when the sun goes down. It wants you to start winding down, it wants you to think about sleeping. And though you may get the HOURS in, if they are off from the light/dark cycle, your body WILL pay.
It was easy for me to refrain from staying up late, as the rewards were so immediate when I began sleeping longer. And that helped with the doing.
And I understand refraining from poisons. But 'won't power can only take you so far.
What can I DO, to make it easier? Substituting good things? Developing habits of behavior so that I never think about the cheesecake? How do I get the same emotional reward from new habits, as I do from mindless eating? Refraining will only take me so far. I need to develop both my skills to make it.
Up at 5:45
9:30 1/8 quiche alsace:
bacon, spinach, swiss cheese
2C cauliflower, fried in
20 minute walk barefoot in the rain
12:15 garlic sausage
peppers, onions, tomatoes, sauerkraut
6 strawberries
cream with
4:30 cheese
5:15 banana split
6:00 grilled cheese sandwich with tomatoes
7:00 do-si-do cookies (many) with
Bed at 9:00
The only good thing about it, is that I decided to write it down. I feel horrible, both physically and mentally.
Mmm... I've gotta make a primal banana split sometime! (I'm guessing yours wasn't but I do like a challenge!)
SW (Nov 22nd 2011): 333
Current Weight as of Nov 25 2015: 248
Short Term Goal: Fit into the shirts I got on my honeymoon at disney and universal in august next year when I go back to for my 1 year anniversary
Met Goal: Be a 2x Shirt, Fit in a standard airplane seat belt without the use of a seat belt extension
Long Term Goal: 166lbs (One day!), Buy whatever cloths I want to wear.
Pain is temporary, quitting is forever- Lance Armstrong #NoExcuses


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Scrapbooking Class
Dina Lanzendorf Instructor
Thursday, 10:00 a.m. - 12:00 p.m.
October 13th, 2016 - Register
Cost $8
Dina Lanzendrof is a Stampin' Up consultant. She has access to lots of new scrapbooking products and will be using these in the two 12 x 12 page layouts she will help the students create each month! This will be a fun, work at your own pace class. If you already know how to scrapbook, she'll show you what to do then get out of your way. If you are a beginner, or unsure what to do, she will take time to work with you until you complete your project.
Everything needed to complete the cards will be provided. You will need to provide your own adhesive. If you do not have any or forget it, Dina will have some available for purchase. She will also have refills available for future sessions. The cost of the adhesive is $8.25 and the refills would be $5.30. This cost is separate from the class cost and would be paid directly to Dina.
Email Trina Stephens at:
firstname.lastname@example.com or call 636-296-7729 ext. 148 to sign up for the class.
Future Scrapbooking Class Dates:
November 10, 2016
December 8, 2016
One Day Weekend Crop
Come join us for a full day of scrapbooking fun! On October 22nd we will crop 9 AM – 6 PM. Dina Lanzendorf from Stampin' Up will have supplies you can use, limited products for purchase and be available help you get started or offer suggestions. You'll have a full table to spread your supplies on and will receive a light breakfast of donuts (or something similar), a box lunch prepared by our catering staff and snacks in the afternoon. The cost for this day is $20. Space is limited.
Register on line at fbcarnoldweb.myshelby.org to save your spot.


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Jean-Daniel & Vadim - BelAmi
Models: Jean-Daniel Chagall and Vadim Farrell
Studio: BelAmi
An afternoon hanging out by a pool for 2 hot muscle boys can quickly turn to sex as you will see today. Jean-Daniel Chagall and Vadim Farrell can't keep their hands off each other when they are hanging out. The big, hard uncut cocks come out fast and we all know Jean-Daniel wants Vadim's big piece in his tight muscle ass. Watch the magic of chemistry with 2 of our most musculed studs in Jean-Daniel & Vadim.


text: Im going to perchase this machine before i do i need to get my grinder squered away. is there a reason you only wrote the Rancilio Rocky or Gaggia MDF as grinder options in the description do you recommend those over the Bartaza vario? as thats the one i was thinking on gettingover 2 years ago


text:
Find a copy in the library
Finding libraries that hold this item...
|Animated films
Animated television programs
Children's films
Feature films
Juvenile works
Video recordings for the hearing impaired
Juvenile drama
Teatro juvenil
|Material Type:
|Animation, Juvenile audience, Videorecording
|Document Type:
|Visual material
|All Authors / Contributors:
Casey Kasem; Frank Welker; Mindy Cohn; Grey DeLisle; Scott Awley; Dexter Smith; Warner Bros. Animation.; Warner Bros. Television.; Cartoon Network (Television network); Hanna-Barbera Productions.; Warner Home Video (Firm)
|1560398663 9781560398660
|OCLC Number:
|Language Note:
|English, dubbed French or dubbed Spanish dialogue, French or Spanish subtitles; closed-captioned.
|Title from container.
|Character designers, Scott Awley, Dexter Smith.
|Voices: Casey Kasem, Frank Welker, Mindy Cohn, Grey DeLisle.
|Target Audience:
|MPAA rating: Not rated.
|1 videodisc (approximately 74 min.) : sound, color ; 4 3/4 in.
|DVD, Region 1, full screen (1.33:1) presentation; Dolby Digital 5.1 surround.
|Series Title:
|Kids movie collection.
|Warner Bros. Animation ; Warner Bros. Television ; Cartoon Network ; Hanna-Barbera Productions.
Scooby-Doo, Shaggy and the crew travel to Scotland on vacation and find themselves unexpectedly tackling their biggest monstrosity ever: the Loch Ness Monster. Does it really exist? Early evidence suggest that the monster does indeed exist, but when something gigantic appears outside a window of Daphne's ancestral family castle, it's up to Scooby-Doo and the crew to solve one of history's longest-running mysteries.
User-contributed reviews
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Related Subjects:(9)
- Scooby-Doo (Fictitious character) -- Juvenile drama.
- Loch Ness monster -- Juvenile drama.
- Detectives -- Juvenile drama.
- Scooby-Doo (Fictitious character) -- Drama.
- Loch Ness monster -- Drama.
- Scooby-Doo (Personaje literario) -- Teatro juvenil.
- Detectives.
- Loch Ness monster.
- Scooby-Doo (Fictitious character)


text:
Failure to Thrive/Constipation: Help Please
Joey, born Oct. 13, 2008 is my second son. He was born weighing 7 lbs and 19 inches long. Now at 20 months, he is 21lbs (♥%) and 32 inches(18%). He was gaining weight...
Started by Jennifer on 07/03/2010 in Mothers Of Special Needs Children
Last update on 07/16/2010 by Angelia


text:
Headache is found among people who take Biotin, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Vitamin D, and have Rheumatoid arthritis . We study 7,100 people who have side effects while taking Biotin from FDA and social media. Among them, 477 have Headache. Find out below who they are, when they have Headache and more.
On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>
Biotin has active ingredients of biotin. It is often used in hair loss. (latest outcomes from Biotin 7,402 users)
Headache (pain in head) has been reported by people with multiple sclerosis, rheumatoid arthritis, high blood pressure, depression, pain (latest reports from 305,848 Headache patients).
On Oct, 17, 2016
7,100 people reported to have side effects when taking Biotin.
Among them, 477 people (6.72%) have Headache
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Hello! Just looking for others who have experienced headaches while using biotin
I am a 25 year old female and I suffer from depression, anxiety and suicidal thoughts. I do not act as I do though, I fight my depression, I rise above and I conquer it every single day BUT when I take biotin I cannot rise above the depression. Biotin is a great vitamin, I just would never recommend it to anyone who suffers from depression.
Hello! Just looking for others who have experienced headaches while using biotin
Hi, I'm a 59-year-old female with Lichen Planus. I started taking biotin and it's appears to have aggravated my lichen planus trifold. Has anybody else experienced this as well?
Several years ago in 2013 I was"diagnosed" with RA. I went through every medication including, humira, embral, to now IV fusions of remicade which has been almost a year. I am not feeling any better and body aches and joint pains getting worse. I started researching my symptoms and lyme kept ...
I had blood work done because I've been feeling sick to my stomach a lot lately. My pancreatic enzymes are elevated. I take low dose of generic topamax and Effexor daily. Has this ever happened to anyone??
Hi I am 30 old female I had MM since 11 months . after stem cell transplant I loss my hair now it had been 3 moths since the stem cell my hair grows slowly my doctors suggesting to take revlimid for 6 months after stem cell but iam afriad that my hair will not grow faster I want to grow my ...
More questions for: Biotin, Headache
I am a 25 year old female and I suffer from depression, anxiety and suicidal thoughts. I do not act as I do though, I fight my depression, I rise above and I conquer it every single day BUT when I take biotin I cannot rise above the depression. Biotin is a great vitamin, I just would never ...
Nine months of taking Biotin and my legs go into hyperextension at random when I am lying in bed. or have just gotten out. Most of my story is on http://gnh1.blogspot.co.uk/ Geoff
Fui intervenida hace un año con reseción parcial de meningioma psmomatoso de fosa posterior en cisterna del tentorio. No se tocó la cola dural que ingresa en el conducto auditivo interno...me quedo insensibilidad en al hemicara, lengua y dientes derecha...con descargas del trigemino
I've had severe headaches for two months. It's coincides with the time period I've been taking synthroid. I've read that there could be a connection.
Good morning I just come across this site while I was looking side effects of mirilax. I had a bad fall in shower and have horrific tear in my shoulder. The doctor put me on some pain medicine and I had me daughter pick up some mirilax for constipation. I have never taken mirilax before but ...
NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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4. Fretless basses, uprights etc.
The fretless bass
The differences regarding body construction are similar to those of guitars. There are basses with solid wooden bodies and bolted or set-in necks. Semi-acoustic basses also add to the palette. Finally, neoteric materials such as graphite expand into modern bass construction.
The fretless bass is a special type of bass instrument. As with classical string instruments it doesnt have any frets. Playing such type of bass needs a lot of practice as well as good hearing because the correct notes have to be played in context to what is heard. While the normal frets have a proper grid for the twelve normal octave notes, the notes on a fretless instrument can be changed continuously, thus, even minor deviations can create horrible tonal clashes. Fretless basses have an awesome fundamental sound but they are not as suitable for beginners for the reasons mentioned above.
The variety of bass shapes developed parallel those of guitars. There are approved standard models and shapes here too. They often originate from brands such as Gibson or Fender and are now being manufactured either identically or in a slightly modified form by southeast Asian producers as well. One such bass classic is the Fender Jazz-bass, which is still being copied down to the smallest detail today.
Along with the approved types available in every price range there is a growing market for high-end products made by brands specializing in manufacturing luxurious electric basses in fancy wood types. The electronics in these instruments is almost invariably active which means that they feature a small built-in battery-powered preamp to enhance the weak pickup signals in advance. Of course fabulous bass sounds can be produced with this technology which requires an accordingly fabulous amp setup to best display these sounds both available at fabulously high prices. Since winning the lottery is still a matter of luck we will focus on the more common bass types.
The upright bass
A further special type of electric bass is the so-called upright bass. It is a double bass which features the characteristics of an electric bass, if you like. As with the double bass, it is placed between the legs of the player and played either standing or sitting, but as a solid wooden instrument it needs to be electrically amplified. This type of bass is rarely used by rock bands maybe because the player is forced to stay in a constant position on stage. But according to insiders, the EUB (electric upright bass) is currently gaining popularity and has been highly regarded by jazz or jazz-rock musicians for years.
In the 50s the German company Framus were already producing an electrically amplified double bass. Their competitors Clevinger were the first to make uprights a lasting success.


text:
General Motors Recall Cases Consolidated
Lawsuits Alleging Economic Losses Sent to Federal Court in Manhattan
Lawsuits against General Motors Co. GM -4.18 % alleging economic losses from ignition-switch defects will be consolidated and sent to a federal court in Manhattan, a panel of judge has ruled.
More than 80 ignition-switch-related civil lawsuits have been filed against GM, most alleging economic damages, such as repair costs and declines in resale value on about 2.6 million cars recalled since February. The average depreciation claim alone might total between $500 and $1,000 a car, according to lawyers who have filed suits against GM.
The lawsuits will be sent to U.S. District Judge Jesse M. Furman, who will handle all pretrial rulings related to the cases. Monday's decision by the seven-judge panel to send the cases to Manhattan doesn't impact the lawsuits over personal injuries or deaths allegedly caused by the ignition default.
In a three-page order, the panel noted that the Southern District of New York is "the most appropriate choice" for the suits, given that "the court is the site of the bankruptcies of both General Motors and Delphi. DLPH -1.56 % "
The federal bankruptcy court in Manhattan, the panel noted, "has already been called upon by both General Motors and certain plaintiffs" to determine whether GM's bankruptcy bars the plaintiffs' lawsuits.
Last month, more than a dozen lawyers gathered in Chicago to argue over where the cases should be sent. Several plaintiffs' lawyers argued for southern California, where the lawsuits over Toyota Motor Corp.'s TM -0.17 % unintended-acceleration lawsuits were grouped. Others, including lawyers for GM, argued for Manhattan.
A spokesman for GM did not immediately respond to requests for comment.
In its order, the panel mentioned that Judge Furman has "some familiarity" with the situation, given that he has heard appeals related to the GM bankruptcy.
Judge Furman, 42 years old, is relatively new to the bench. He was nominated in 2011 by President Barack Obama and hasn't yet gained vast experience handling large-scale product-liability cases.
Whether many of the "economic-loss" cases are allowed to go forward for now is an open question.
GM lawyers are trying to use the auto maker's bankruptcy petition in June 2009 to insulate the company from depreciation-related claims before then.
Plaintiffs' lawyers claim that would violate constitutional due-process rights, since GM allegedly knew about the ignition-switch problems but kept them secret for years. U.S. Bankruptcy Judge Robert Gerber in New York is expected to rule by the end of summer on whether GM's bankruptcy bars civil suits from moving forward.
Also unclear is whether injury and death cases will be consolidated and sent to New York. So far, only a few have been filed, though plaintiffs' lawyers claim that several hundred more could be in the works.
In regard to death and injury cases, the defense strategy by GM includes a compensation program that will be launched in August and led by Kenneth Feinberg, the lawyer who managed the U.S. government's September 11 Victim Compensation Fund. GM hasn't said how much money it will put into the fund. Victims and their families who file claims could get a check from the company, but they likely would have to agree not to seek damages from GM in court.
The internal report released by GM last week may give plaintiffs' lawyers ammunition going forward. The author of the report, Anton Valukas, excoriated the company, saying its "search for root cause became a basis for doing nothing to resolve the problem for years."
GM Chief Executive Mary Barra said the report demonstrated a "pattern of incompetence and neglect."
—Jeff Bennett contributed to this article.
Write to Ashby Jones at firstname.lastname@example.com


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phone view phone(651) 962-4858 Address 225 MSL
1000 LaSalle Avenue
Minneapolis, Minnesota 55403
United States
1000 LaSalle Avenue
Minneapolis, Minnesota 55403
United States
http://www.stthomas.edu Send Email
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Intellectual Property Attorney The candidate will join the intellectual property team. Must have 3+ years of experience in drafting and negotiating agreements and policies (e.g. license agreements, ...
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A. Harrison Barnes is a well-known attorney throughout the United States. As a member of the Malibu community, Harrison is committed to serving the needs of Malibu residents and businesses in legal matters.


text:
Pacific Airlines Future Destinations
A selection of articles related to pacific airlines future destinations.
Original articles from our library related to the Pacific Airlines Future Destinations. See Table of Contents for further available material (downloadable resources) on Pacific Airlines Future Destinations.
- A Treatise on Astral Projection, Part 4: More Rope Techniques
- ROPE is a very effective projection technique, but it still has to be learned to be effective. I would like to elaborate on a couple of points about the technique, inspired by the feedback I have received so far. There is NO visualization required - AT ALL -...
Parapsychology >> Astral Projection
- Several Tarot Spreads
- Classic 3-Card Spread This classical three-cards-spread can briefly point out the development of issues. 1. The present situation, also representing the questioner. 2. Circumstances in the past that led to the present situation. 3. Future development. The...
Divination >> Tarot Cards
- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
Mystic Sciences >> Astrology
- Apple Divination
- We have all heard and used the expression "An apple a day keeps the doctor away." This expression is based on a very old superstition and is one of many associated with apples. I am quite sure that you have all held an apple in one hand and twisted...
Psychic Abilities >> Divination
- An Overview of Different Types of Scrying
- Scrying is a method of divination. It consists of gazing into a crystal, a mirror or some water for example, anything shiny really, in order to enter altered mind states...A good cliché that best describes scrying is the gypsy fortune-teller and her large...
Divination >> Scrying
- Hulse, David Allen
- From an early age, David Allen Hulse has made a diligent study of the alphabets of the ancient world. Even as a child, David possessed a great affinity for the alphabets of Egypt, Phoenicia, and Greece. In college, a reading of MacGregor Mathers' Kabbalah...
Real Interviews >> Authors
Pacific Airlines Future Destinations is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Pacific Airlines Future Destinations books and related discussion.
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- It is becoming readily apparent that Calgary-based WestJet will likely soon join the long list of airlines flying Canada-to-Asia routes.
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EDraw Flowchart Software 3.2EDrawSoft - 9.3MB - Shareware
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A Recent Favorite:
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Why don't you go browse some Comics or Editorials and pick a few to favorite?
Recent Comments
Flashforward to 2013 and all the kids are sitting at the dinner table with independent electronic gadgets and the parents don't have any problem with this at all because they are busy "being social" by sharing the same table while they each play with their own little electronic gadgets.
Oh leave them alone…they're having a capital time.
Kick them to the curb?
Danae needs a teacher to explain that the Bill of Rights does not grant people rights but protects those identified natural rights from government intrusion and interference.
Neh. The purpose of the Bill of Rights is not to grant rights to the citizenry but to protect those identified natural rights from the interference and intrusion of government.
just sayin'
Anniefan: that usually isn't the way with backpacks.
Anyone who doesn't understand why they are tense does not have children of his own. As much as we love them, there are times when being a parent is rather like being pecked to death very slowly. It makes us crabby. (I haven't read a paragraph in a novel without interruption for ten years. I was interrupted three times before finishing this parenthetical aside.)
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1964, with the advent of sophisticated neuropsychological testing in can you take viagra every day the mid-19th century (Benton. Milner, 1961), our understanding of frontal lobe function expanded to include cognitive abilities encapsulated under the rubric of "executive functions." This label encompasses a diverse collection of processes, including divided and sustained attention, working memory, flexibility of thought, set shifting, motor sequencing, planning, and the regulation of goal-directed behavior (Hecaen & Albert, 1975. Interpretations of observations such as these, coupled with early findings that damage to the frontal lobes does not translate into gross changes in 257 intelligence , suggested a principle role can you take viagra every day of the frontal lobes in personality and emotion. Lezak, 1995).
There are clear interactions between stress, glucocorticoids, can you take viagra every day and mesocorticolimbic dopaminergic neurons, and between dopaminergic neurons and vulnerability to drugs of abuse. Joels and de Kloet, 1990, 1994), and glucocorticoids can interact with dopamine reward circuitry in the basal forebrain that may be independent of direct glucocorticoid–dopamine interactions. Glucocorticoid receptors are localized in brain monoaminergic neurons, particularly in the ventral tegmental area (Harfstrand et al., 1983), although direct cellular interactions between stress hormones and dopamine neurons have been difficult to document. Acute administration of most drugs of abuse in animals activates the HPA axis (see earlier chapters), but with cocaine and alcohol these acute changes are can you take viagra every day blunted with repeated administration (Rivier et al., 1980. During withdrawal, there are, again, increases in the activity of the HPA axis for most drugs of abuse (see earlier chapters).
However, glucocorticoid receptors have pivotal regulatory roles in many regions of the brain (de Kloet, 1989. Zhou et al., 1997, 2001).
CARDIOVASCULAR DRUGS The definition of cardiovascular drugs in a broad sense includes antiarrhythmics, coronary can you take viagra every day vasodilators, antihypertensive agents , and lipidregulating agents. Antiarrhythmic drugs reaching high plasma concentrations enhance the risk of sinoatrial and atrioventricular block, and toxic concentrations may induce tachycardia (27–26). The information below will integrate clinical, biochemical, and pathological aspects and mechanism of actions associated with the hepatotoxicity of cardiovascular and antidiabetic drugs. II. The number of diabetic patients in the United States and Canada for the same period was 4.7% of males and 1.6% can you take viagra every day of females, notwithstanding that 40% of diabetics are not diagnosed and morbidity in the adult population is increasing at alarming rates (27,27).
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Crime & Prostitution
Generally Mombasa is one of the safest towns in Kenya, thats because of the tourist industry, but still every week someone is killed by muggers.
The Kenyan authorities are not doing enough to reslove the problem. Majority of the incidents happen to rich local businessmen rather than tourists.
Saying that a couple of years ago raiders raided a hotel late at night, stole everything from the hotels safe deposit box and shot the guard. Most hotels in mombasa have safe deposit boxes at reception rather then in the rooms.
So don't flash your cash in or outside your hotel, don't wear any jewelrey, never walk on the beach at night or in secluded areas.
Prostitution is big in mombasa, and 2 in every 5 prostitutes are infected with AIDs
Do not use drugs (GANJA). They will ask you to join them but don't.
You never know if it is a policemen off duty who is trying to frame you for bribe money.
Also you really don't want to go to a kenyan prison...
telephone calls
Never use a telephone in a hotel, normally in a hotel it is always a bit more expensive but in mombasa it is crazy how much they charge in tha hotels.
Best thing is to go to a local village, and go to a "phone central" (don't expect a big building, it is just one room with a person on a table)
They are really helpfull and sooo cheap.
(be aware to most countries is 3 minutes the maximum you can call)
- 1
Instant Answers: Mombasa Island
Get an instant answer from local experts and frequent travelers


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There is no doubting the location of this hotel will probably make up for the fact that the rooms are a bit tired and in need of a make over. Its not to say they are untidy, mine was clean and was kept that way by the hotel but the decor, furniture, TV (not a flatscreen) etc are all from the 90's. If the hotel was advertised as a 3.5* to 4* it would have been more accurate.
If you get a good deal, it would be worth staying at this hotel. The staff are great, its in the middle of everything and you probably wont be spending that much time in your room anyway.
- Official Description (provided by the hotel):
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There are certain general rules in football that always seem to hold true: Defense wins championships. Win the turnover battle and you'll win. And, when playing the Cincinnati Bengals, just be patient -- they'll find a way to lose.
Rule No. 3 came in very handy for the New Orleans Saints on Sunday at Paul Brown Stadium. Trailing the Bengals 30-27, the Saints faced a fourth-and-2 deep inside Cincinnati territory. The easy decision would have been to kick the field goal, tie the game and take your chances in overtime.
But, remember, it's the Bengals. Sean Payton kept his offense on the field and quarterback Drew Brees began directing guys in motion and barking out snap counts. It should have been obvious to anyone in the stadium or watching on television that the Saints were trying to draw the Bengals offside.
And, of course, the Bengals fell for it. Defensive tackle Pat Sims jumped into the neutral zone and drew a flag. That gave the Saints a first down.
On the very next play, Brees threw a 3-yard touchdown pass to Marques Colston to give the Saints the win.


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Best Fishing Times: 1:28AM to 3:28AM, and 7:45PM to 9:45PM
Alternate Fishing Times: 7:15AM to 9:15AM
Fishing Situk Lake, AK on 10/26/2016 will be best from 1:28AM through 3:28AM, and from 7:45PM to 9:45PM. If those times won't work for you, 7:15AM to 9:15AM looks promising. Remember to adjust these times based on barometric pressure, and weather changes.


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This preview shows pages 1–3. Sign up to view the full content.
arranty is an age-old concept. In sales and lease law, a warranty is an assurance by one party of the existence of a fact on which the other party can rely. Sellers and lessors warrant to those who purchase or lease their goods that the goods are as represented or will be as promised. The Uniform Commercial Code (UCC) has numerous rules governing product warranties as they occur in sales and lease contracts. Those rules are the subject matter of the first part of this chapter. A natural addition to the discussion is product liability: Who is liable to consumers, users, and bystanders for physical harm and property damage caused by a particular good or its use? Product liability encompasses the contract theory of warranty, as well as the tort theories of neg- ligence and strict liability (discussed in Chapter 4). Most goods are covered by some type of warranty designed to protect buyers. Article 2 (on sales) and Article 2A (on leases) of the UCC designate several types of warranties that can arise in a sales or lease contract, including warranties of title, express WARRANTIES W warranties, and implied warranties. We discuss these types of warranties in the following subsections, as well as a federal statute that is designed to prevent deception and make war- ranties more understandable. Warranties of Title Title warranty arises automatically in most sales contracts. The UCC imposes three types of warranties of title. Good Title In most sales, sellers warrant that they have good and valid title to the goods sold and that transfer of the title is rightful [UCC 2–312(1)(a)]. Sharon steals goods from Miguel and sells them to Carrie, who does not know that the goods are stolen. If Miguel reclaims the goods from Carrie, which he has a right to do, Carrie can then sue Sharon for breach of warranty. When Sharon sold Carrie the goods, Sharon automatically warranted to her that the title conveyed was valid and that its transfer was rightful. Because this was not in fact the case, Sharon breached the warranty of title imposed by UCC 2–312(1)(a) and became liable to the buyer for the appropriate damages. ■ ■ EXAMPLE 17.1 323 AFTER READING THIS CHAPTER, YOU SHOULD BE ABLE TO ANSWER THE FOLLOWING QUESTIONS: 1 What factors determine whether a seller's or lessor's statement constitutes an express warranty or mere puffery? 2 What implied warranties arise under the UCC? 3 Can a manufacturer be held liable to any person who suffers an injury proximately caused by the manufacturer's negligently made product? 4 What are the elements of a cause of action in strict product liability? 5 What defenses to liability can be raised in a product liability lawsuit? LEARNING OBJECTIVES 95735_17_Ch17_323-344.qxp 11/6/08 7:51 AM Page 323
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Express Warranties A seller or lessor can create an express warranty by making representations concerning the quality, condition, descrip- tion, or performance potential of the goods. Under UCC 2–313 and 2A–210, express warranties arise when a seller or lessor indicates any of the following: 1
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9 search results for Area 52
Rodrigo y Gabriela - "Area 52"
Type: Event | Date: Tuesday, Jan 24, 2012This two-disc set includes a 'making-of' documentary on DVD
Summit Entertainment heading to 'Area 52'
Type: Article | Date: Tuesday, Sep 27, 2011Studio adapting 2001 Brian Haberlin sci-fi title for the big screen
Ginormous Double Pack - Monsters vs. Aliens/B.O.B.'s Big Break in Monster 3D
Type: Event | Date: Tuesday, Sep 29, 2009Includes - Monsters vs. Aliens (2009), MPAA Rating: PG B.O.B.'s Big Break (2009) Monsters vs. Aliens When human-hating aliens disrupt earthbound cable-television signals, it's up to a monster-hunting superhero to take out the pesky extraterrestrials and ensure that television viewers are not deprived in this animated adaptation of the popular comic-book series. The DreamWorks Animation release is being helmed by Shrek 2 director Conrad Vernon and Shark Tale's Rob Letterman. ~ Jason Buchanan, All Movie Guide B.O.B.'s Big Break Your favorite characters from Monsters vs. Aliens return in this animated 3D adventure that follows B.O.B. (voice of Seth Rogen), Dr. Cockroach P.H.D. (voice of Hugh Laurie), and the macho Missing Link (voice of Will Arnett) on their mission to outsmart grizzled General W.R. Monger (voice of Kiefer Sutherland) and stage a daring escape from Area 52. ~ Jason Buchanan, All Movie Guide
Review: Yeah Yeah Yeahs, 'Mosquito'
Type: Post | Date: Tuesday, Apr 16, 2013Band's first album in four years puts you on a train, sends you to mars and wears you out
Watch: A middle-aged pageant queen melts down on 'Crown Chasers'
Type: Post | Date: Wednesday, Jun 26, 2013Jocelyn has a Stuart Smalley moment with the mirror
John Constantine faces his dark side in 'Forever Evil: Blight'
Type: Article | Date: Monday, Oct 7, 2013Writer Ray Fawkes also shares his reaction to announced NBC series
Confirmed: 'Rock of Ages' adds '30 Rock's' Alec Baldwin to the club
Type: Article | Date: Sunday, Mar 6, 2011Tom Cruise, Julianne Hough and Mary J. Blige confirmed
Is 'Superman: Doomed' more than just a rehash of 'Death of Superman'?
Type: Article | Date: Tuesday, Mar 25, 2014DC's Superman writers talk Man of Steel versus Doomsday
DC promises bad things in store as 'Trinity War' leads into 'Villain's Month'
Type: Article | Date: Tuesday, Aug 27, 2013DC's New 52 panel talks 'Trinity War' ending badly for the heroes at Fan Expo Canada


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To show you the most accurate prices, TTPM only displays our pricing tool on products which we've reviewed in the past three years.
We love it when a movie-based video game does something unique rather than just making a game that plays through the movie. That's exactly what D3 did with The Croods: Prehistoric Party.
As you might expect, all of the main characters and familiar settings from the movie are in the game but what makes this game different (from many movie games) is that it's a party game where players choose a character as their token and select a setting as a game board. Players take turns rolling a dice and moving along the board's spaces just like in a classic board game. It's like a Mario Party game with Croods characters and humor.
There are five unique game boards with mini-games scattered along each board. When one player lands on a Mini-game space, all players are pulled off the board and into a challenge. These challenges are made up of 30 Croods-themed mini-games that are all fun and funny. The mini-game, "Shell Sweeper" is like a game of Bejeweled with four players competing at the same time to line up matching shells. "Ramu Rampage" is a race with the players riding on prehistoric-looking ostriches. In "Cloud Bounce", you bounce on clouds and the other players to reach floating handprints. "Fire Tail Trail" is like the Tron light cycles race where you have to trap someone in the trail left by your character.
People who have never seen the movie have been enjoying this game but fans of the movie are really going to get an additional kick out if it.
It's perfect for families to play together and one that grownups and kids will equally enjoy. Kids as young as 5 and inexperienced (gaming) adults should have no problem figuring out how to play.
Anywhere from one to four people can play together but the game is most fun with multiple people. The game will assign computer-controlled players to the game for any less than four people, which means if one person is playing alone, they will be competing against three computer-controlled players.
The Croods: Prehistoric Party is available for the Nintendo Wii U, Wii, 3DS and DS. For our review, we played the Wii edition, which is essentially the same as the other editions.
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Our research aims at understanding the basis for differences between individuals in human drug metabolism, toxicity and drug response. The emphasis is on genetic polymorphism of the genes encoding drug transporters, drug metabolizing enzymes and drug targets.
The research performed in our laboratory examines the genetic basis for interindividual differences in drug response and adverse drug reactions (ADRs).
We start with patient outliers and examine mechanisms and genetic factors explaining the differences. Genetic biomarkers are identified and used in the clinics.
Among our previous discoveries is the stable gene duplication/amplification in the human genome, the identification of ultrarapid metabolizers of drugs and the identification of several different gene variants of importance for the efficacy of drug treatment.
In addition, we are characterizing the human hepatic epigenome responsible for interindividual differences in drug metabolism and transport, developing a new approach for treatment of colon cancer and utilizing novel mouse models and human genomics in order to elucidate new bases for treatment of depression.
We are also developing novel in vitro methods based on hollow fiber bioreactors and spheroids that can predict drug toxicity, thus finding new ways of producing hepatocytes and non parenchymal liver cells from stem cells in collaboration with Cellectis (Cellartis).
Group members
Tommy B Andersson Adjunct professor Isabel Barragan Assistant professor Pedro Gil Senior researcher Delilah Hendriks PhD student Anna Huguet Ninou Student Magnus Ingelman-Sundberg Professor Maxim Ivanov Associated Inger Johansson Senior lecturer Marin Jukic Scholar Mikael Kozyra Student Volker Lauschke Postdoctoral researcher, Marie Curie Maria Isabel Mendes Veiga Associated Souren Mkrtchian Senior researcher André Nobre Postdoc Åsa Nordling Biomedical scientist Teodora Petrova Student Ina Schuppe Koistinen Associate professor Sarah Sim Associated Sarianna Tuovinen Student Emilia Undorf Student Sabine Vorrink Postdoc
1. Genomic and epigenomic regulation of human hepatocyte formation and function. Implications for drug development and hepatotoxicity
Summary. Studies of liver function, drug and viral induced hepatotoxicity have previously been impossible in in vitro systems due to the rapid de-differentiation of human hepatocytes in cultures. We have worked out conditions for formation of hepatic spheroids in normal and diseased states which are phenotypically stable for several weeks in vitro. Furthermore we have developed novel methods for analyses of the hepatic genome allowing single nucleotide analyses of 5-mC as well as 5-hmC. In this project 220 different livers and spheroid systems obtained from human liver donations or cryopreserved hepatocyte cultures, are used in combination with different types of non-parenchymal cells, in order to
- Evaluate the mechanistic basis for de-differentiation of hepatocytes to progenitor cells in 2D cultures,
- Study and improve the differentiation process of stem cells to fully differentiated hepatocytes,
- Evaluate short term and long term (epigenomic imprinting) epigenomic regulation of hepatic gene expression following de-differentiation or drug treatment taking into account both 5-mC and 5-hmC using novel protocols for genomic analyses,
- Evaluate the roles of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the processes of liver de- and re-differentiation and hepatic gene expression,
- Develop novel in vitro systems for prediction of drug hepatotoxicity including the identification of novel biomarkers, investigate epigenomic regulation in diseased livers and in diseased liver spheroid models.
This information will be of importance i) for increased possibilities to avoid the development of hepatotoxic drugs, ii) to develop novel protocols for formation of hepatocytes from stem cells, iii) for understanding the bases for interindividual differences in drug metabolism and drug hepatotoxicity and iv) for understanding the genome alterations in different liver diseases.
The spheroid model
In our lab we have established and further developed novel spheroid based 3D systems for studies of liver function and properties in vitro (cf. Gunness et al., 2013). Starting with hepatocytes obtained from the cell transplantation unit at Huddinge University Hospital or with cryopreserved hepatocytes we form spheroids from primary human hepatocyte fractions (PHH spheroids) using the InSphero gravity plus system or the Corning ultra-low attachment plates. In the spheroids, the cells have relevant cell-cell interactions, a cell-extracellular matrix (ECM) contact, improved cell polarity and form functional bile canaliculi (see Figure 2). Our work has shown that the spheroids i) express albumin, urea etc and the major forms of hepatic cytochrome P450s for at least 54 days, ii) retain to a great extent their phenotype from the liver resulting in mosaic formation (perivenous vs periportal) in the spheroids, iii) can be infected with virus, iv) can be formed from different proportions of hepatocytes and different types of non-parenchymal cells.
De-differentiation of human hepatocytes and re-differentiation in hepatocyte spheroid formation
In collaboration with Takara Bio Europe AB in Gothenburg and recently with EU EBiSC Stem Bank we study mechanisms of formation of hepatocytes form stem cells (Sivertsson et al., 2013) as well as mechanisms of de-differentiation of hepatocytes with the aim to understand critical factors needed for successful differentiation of stem cells into hepatocytes.
To understand the dedifferentiation and the phenotypic difference of the hepatocytes in 3D spheroids as compared to 2D hepatocyte cultures, we follow >285,000 full-length transcripts, 245,000 coding transcripts, 40,000 non-coding transcripts, 1200 miRNAs and 12000 lncRNAs during de-differentiation and re-differentiation of human hepatocytes from three different liver donors.
Novel methods for analyses of the dynamics of the hepatic epigenome.
Using the sensitive and reliable LC-MS method for the detection of cytosine modifications, we recently discovered in collaboration with the Estonian Genome Project that genomic DNA from adult human livers contain a substantial level of 5hmC (Ivanov et al., 2013). In this study we also enriched genomic DNA samples from 8 fetal and 7 adult livers for the 5hmC-containing fraction, subjected it to next-generation sequencing (NGS) and generated the first genome-wide map of 5hmC peaks in the hepatic epigenome. We have now used a TAB-Methyl-SEQ protocol for the epigenomic profiling of ADME genes in 20 adult human livers. We can then find that the bisulfite methods shadows regions where 5hmC is heavily enriched as illustrated in Figure 4.
The new powerful tools for determining the 5-hmC and 5-mC distribution allow site-specific and inducible manipulation of methylation and hydroxymethylation patterns at candidate genomic loci and result in the functional validation of epigenetic polymorphisms. Issues that are in addition considered are the regulation of epigenomes by epidrugs, drug inducers and during hepatocyte differentiation.
Furthermore the epigenomic alterations seen during steatosis, hepatitis (drug or virus induced) as well as fibrosis are studied both in the liver specimens characterized for these conditions by a pathologist as well as in the diseased spheroid models where such conditions have been induced.
The project encompasses completely novel techniques for studying epigenome regulation taking both 5mC and 5hmC modifications into account which is important in view of our recent finding (Ivanov et al., 2013) that the activatory modification 5hmC accounts for about 30-40 % of all cytosine modifications in active genes in adult liver and based on our preliminary data here shown which shows on a single cytosine resolution the erroneous results obtained from sole bisulfite analyses missing elements where a high amount of 5hmC modification has occurred.
The newly developed liver in vitro systems allow long term studies of liver functions in vitro for 4-5 weeks at a high and stable level of differentiated hepatocyte function. This in vitro model also allows studies of diseased liver in vitro like drug- or virus induced hepatitis, steatosis, fibrosis etc. Furthermore, the phenotypic preservation of the hepatocyte phenotype in the spheroids and their de-differentiation and re-differentiation during spheroid formation, allows an investigation of the signal transduction systems and mechanisms of importance for developing new protocols for stem cell derived hepatocyte formation.
In conclusion, the projects allow to utilize novel technologies for understanding the basis behind hepatic gene regulation and hepatocyte differentiation, things that are of high importance for optimizing drug therapy and for development of primary cell and stem cell derived systems that can facilitate drug development in the future.
2. CYP2W1, a novel target for colon cancer therapy
We have found and characterized novel specific forms of P450 in cancer cells and in extrahepatic tissues. One interesting enzyme is CYP2W1, which is expressed in fetal colon but not in adult tissue, except for colon tumors. We have found in collaboration with David Edler found that the CYP2W1 expression can serve as a prognostic marker for malignancy.
In collaboration with Laurence Pattersson in Bradford, we have also been able to identify chemicals that can be bioactivated by CYP2W1 in the cancer cells to effectively kill the cells at 300 nM concentration. We are making xenograft models for treatment of colon cancers in vivo using these substances and found very promising results with respect to killing of colon cancer tumors in vivo with these agents. We will in due time develop chemical structures that can possibly be used in vivo in human for treatment of colon cancer.
The CYP2W1 gene is evolutionary conserved; it is expressed in embryonic gastrointestinal tract, and remained for a short period in the neonatal tissues, followed by epigenetic silencing throughout the adult life. The Cyp2w1 null mouse model has been established in our lab which preliminary shows a phenotype and we are currently studying its endogenous function in embryogenesis, particularly in the gut development.
3. Endogenous function of CYP2C19: Role in brain and liver phenotypes
The CYP2C19 enzyme metabolizes endogenous and synthetic psychoactive compounds including steroid hormones, cannabinoids, SSRIs, tricyclic antidepressants, and benzodiazepines. Two major variant alleles are known, CYP2C19*2 which is defective and CYP2C19*17, identified by our group, which causes increased enzyme expression.
We detected CYP2C19 expression in fetal human brain and in collaboration with Nancy Pedersen, we showed that the presence of two defective (CYP2C19*2) alleles causes a decrease in depressive symptoms. We found that transgenic mice containing human CYP2C19 gene also show expression of this gene in developing brain, as well as decreased hippocampal volume, anxious phenotype, and increased hippocampal activation after acute stress. Currently, we utilize this model to study the role of CYP2C19 in developing brain and to identify molecular mechanisms of its anxiety- and depression-like phenotype. In addition, we are conducting studies with the aim to translate present and prospective findings from this model to psychiatric patients.
Participation i EU-projects
Notox. Leader of work package 1.
Scr&Tox. Participant in work package 1 and work package 2.
MIP-DILI. Leader of work package 2.
SafeSciMET. Responsible for Course 6.3 on pharmacogenomics.
Financial support
- Swedish Research Council
- Swedish Cancer Society
- Hjärnfonden
- European Union, FP7
- Colipa
- Department of Physiology and Pharmacology
- AstraZeneca
- Varia
Selected publications
Stem cell-derived systems in toxicology assessment.
Stem Cells Dev. 2015 Jun;24(11):1284-96
Polymorphic expression of CYP2C19 and CYP2D6 in the developing and adult human brain causing variability in cognition, risk for depression and suicide: the search for the endogenous substrates.
Pharmacogenomics 2014 ;15(15):1841-4
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
BMC Genomics 2014 Oct;15():860
Epigenetic mechanisms of importance for drug treatment.
Trends Pharmacol. Sci. 2014 Aug;35(8):384-96
Whole-exome sequencing reveals defective CYP3A4 variants predictive of paclitaxel dose-limiting neuropathy.
Clin. Cancer Res. 2015 Jan;21(2):322-8
Personalized medicine into the next generation.
Ingelman-Sundberg M.
J Intern Med. 2015 Feb;277(2):152-4.
High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme.
Pharmacogenomics J. 2015 Jun;15(3):288-92
In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes.
Nucleic Acids Res. 2013 Apr;41(6):e72
Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.
Clin. Cancer Res. 2013 Jun;19(11):2952-61
High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.
Pharmacogenomics J. 2014 Aug;14(4):343-9
Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function.
Genome Biol. 2013 Aug;14(8):R83
Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.
Mol. Psychiatry 2014 Jun;19(6):733-41
Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.
J. Biol. Chem. 2012 Feb;287(9):6307-17
Vacant positions
Applications for postdoctoral fellows are welcome. If interested, please send a cover letter and an updated CV to Magnus Ingelman-Sundberg, research group leader.
Contact us
Magnus Ingelman-Sundberg
|+46-(0)8-524 877 35
|Organizational unit:
|Ingelman-Sundberg Magnus group - Pharmacogenetics


text:
Chapter Fifteen. Return to Sender: Horace's sermo from the Epistles to the Satires*
- Gregson Davis
Published Online: 8 FEB 2010
DOI: 10.1002/9781444319187.ch15
Copyright © 2010 Blackwell Publishing Ltd
Book Title
A Companion to Horace
Additional Information
How to Cite
Cucchiarelli, A. (2010) Return to Sender: Horace's sermo from the Epistles to the Satires*, in A Companion to Horace (ed G. Davis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444319187.ch15
Editor Information
Andrew W. Mellon Distinguished Professor, Department of Classical Studies, Duke University, USA
Publication History
- Published Online: 8 FEB 2010
- Published Print: 12 MAR 2010
Book Series:
ISBN Information
Print ISBN: 9781405155403
Online ISBN: 9781444319187
- Summary
- Chapter
- Return To Sender - Horace's sermo from Epistles to the Satires*;
- Greek noun epistolē - finding its way into Latin (epistula) at an early date;
- Horace - possessing distinct editorial sensibility - in arranging his poems in book form;
- Maecenas–Lollius, in reverse order, Lollius–Maecenas forming"double frame" of liber;
- principle of disposition - recognized in identity of Horace's recipients;
- image of young Lollius, caught up in dazzling social and literary diversions of Rome;
- first book of the Odes - ending with Persicos odi, puer, apparatus;
- Epistles, figure of Aristius Fuscus - evoking the memory of last two satires of Book I;
- "Interval" on Thirteenth Epistle - Vinnius Asina, and Augustus;
- "Personal" revelations - Horace's sermo from Satires to the Epistles
This chapter contains sections titled:
The frame and beyond: Lollius, Celsus, and Albius
In the middle: the boundary of ten, Maecenas and Aristius Fuscus
"Interval" on the Thirteenth Epistle, Vinnius Asina, and Augustus
Inside the frame II : Lollius and Maecenas (in reverse order)
"Personal" revelations: Horace's sermo from the Satires to the Epistles


text:
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Limit 1 per person, may buy 1 additional as a gift. Limit 1 per visit. Valid only for option purchased. Appointment required. Consultation required; non-candidates and other refund requests will be honored before service provided.


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I'm pleasantly surprised by the wealth of good advice given amongst comeback players. Everyone's in general agreement (i.e., soft long tones & flexibility). A very refreshing change from the brag-fest that eventually takes place in most forums!
I'm pleasantly surprised by the wealth of good advice given amongst comeback players. Everyone's in general agreement (i.e., soft long tones & flexibility). A very refreshing change from the brag-fest that eventually takes place in most forums!
Geoff Winstead
Author of The Real Way to Play the Cat Anderson Trumpet Method - A Step by Step Approach to the Upper Register
Yamaha 6310ZS Shew
Conn Connstellation 38B
FoKus Artist Model 10.5
IMO One of the interesting things about Mature Aged Students (Comeback Players) is their tendency to listen to what you say (then they generally analyse the crap out of your comments) - all this allows the learner to compare what they already know with the gems you provide. As we age our brains become less "flexible" compared to a youngster's brain - we don't learn as fast, but we sure learn smarter.
Hi Guys,
Just had to chime in on this as I know how frustrating it is looking back at what you could do as a player in school, etc. and comparing to now as a comebacker.
Some really good suggestions listed in previous posts, but what usually kills range and endurance for ALL players is a lop-sided approach. Using 80% chops and 20% air. The more you tense and pinch, the less you'll blow. If you reverse this and use 80% air stream (controlled of course) and 20% chops you'll get a better tone, better range, longer endurance, etc.
Take this test - say your range caps off at an A above the staff as it was stated in the first post. Play a 3rd space C with your tuning slide pushed all the way in with a tuner. You'll find that you'll have to pull the note down. Chances are very good that tension is already building to achieve this note. Bend the pitch by pushing your lips more toward the mouthpiece and backing them up with air support. BREATHE into your abs!!!! Have good breath support... this will all be useless if you don't support the notes. Once you get comfortable with bending the pitch, try bending it down 1/2 step (in tune) and back up. This will help START a habit of playing more relaxed.
It's NOT an immediate fix, but nothing of true value ever is quick / easy.
Find out more - visit my site. Brass Player Solution: Lessons, Videos, Music Stands, Help for Trumpet and Trombone players
Keith Fiala
Thanks for the all the replies....
As a "mature aged student" - as Tedh1951 said, I am taking my time and carefully listening to myself. I have no intention of blasting the windows out or popping a blood vessel trying to hit the high "C" or even a high "D".
I worked on lip slurs after dinner tonight and took my time, slowly listening to myself.
Open: C, G, C, E, C, G, C..repeat
1: low Bb, F, mid Bb, D, mid Bb, F, low Bb..repeat
12: low A, E, mid A, C#, mid A, E, low A..repeat
Then I went higher:
12: E, mid A, C#, high A, C#, mid A, E,..repeat
If I crackle on the high A, then I go back to the low lip slurs and keep practicing. Eventually, I'll get back in shape and get my clear tone and range. It's a lot of fun getting back into playing after all these years!
in spite of your "anxiousness" to play like you did in '79, keep in mind that we are creatures of habit and even playing the trumpet requires habits for things to become easy.
My recommendation is a daily "routine" that you really play every day! There are 3 things that belong in there in equal quantity: Long tones, slurs and easy tunes (like out of a hymnbook).
The long tones give you connection to control, the slurs build power and range and the tunes, well, music is really the reason that we play trumpet. The daily part gives you a frame of reference and stability after a month or so.
This daily routine should be played as softly as possible as brute force actually slows down progress! I would suggest starting with this routine 30 minutes long (10+10+10) - EVERY DAY. If you have more time and chops, you can add technical studies at the end - and only at the end. Music (the tunes) should NEVER be practiced when your chops are tired. It deserves quality time, not what is left over!
Whenever I feel blue, I start breathing again.
That website I mentioned before www.8notes.com is pretty neat. As far as easy tunes, I have printed out "Danny Boy" for trumpet, and play that very nice and slowly as it should be played.
One thing that I know I shouldn't do - and have stopped doing - is struggling, wincing, and fighting my trumpet, to hit that high "C". It will come in time. Right now, like you said, I will work on long tones, slurs, and some easy tunes.
1967 Holton Collegiate --> my old sentimental school band trumpet. I just can't part with it!
"I know you are new here and don't know the site yet.....
But THAT kind of talk is not going to win you any friends here!
You MUST mash that mouthpiece against those lips and pound out the highest notes you can....and then exaggerate how high you can play by at least 6 full tones."
How rude!
Last edited by heulwen; 04-22-2009 at 09:34 AM.
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Marshall Headphones - 'Major' Over Ear (Black)
" I'm a professional DJ/Producer. In my rider I ask that the venue supply the headphones. So I have at least 100 pairs of headphones, and that's after giving away the majority of them to friends. Not going to bother to run off every pair but I've tried just about every pair out. Just before I was about to play in Stockholm I received a pair of these Marshall Major FX headphones..." --inthere
Stanton Dynaphase Sixty
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Stanton Dynaphase Fifty
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Nakamichi SP-K100W
" I picked these Nakamichi headphones up from Donny B's, an electronic shop in Kenora, Ontario. I'm quite sure they are a Radioshack for the most part. I am not sure if they are around anymore, because they were selling everything away when I got the headphones, including these headphones. I got them for $20, and he told me they were originally $150. I can find reviews or sales of this..." --thepiper92
Nakamichi NK850 "Precision Sound"
"Sears had a large clearance sale on Nakamichi audio this past weekend. As I needed an excuse to get out of the house following the Alberta Clipper that just hit Chicago, I purchased around $18.00 worth of clearance headphones at my local Sears for in-store pickup. At steep discounted rates, $18 was eight (8) headphones; three of them were the Nakamichi KN850 Fashion Headphone in Blue, Green,..." --AustinValentine
Nakamichi 900 Studio Bi-Fold Headphones
Elegant, pure and polished. The beautifully crafted NK900 has been conceptualized and heavily inspired by the iconic aviator, which is a staple piece in every eyewear collection. The Conception of the modern-retro NK900 was painstakingly designed and refined to perfection with the needs of the most matured and tasteful of audiophiles in mind. The fusion of the aviator's timeless design...
Stanton Dynaphase Sixty-A Headphones
I've been looking for someone that has these or has seen them before, I have a pair and have looked in many places but can't find these headphones ANYWHERE. No info, no pics, nothing...If anyone knows of these headphones or at least seen them in the past, please contact me ASAP. They were my dad's when he was younger. THESE ARE NOT STANTON DYNAPHASE SIXTY HEADPHONES, THEY ARE...
Nakamichi NHP850
HD Professional DJ Headphone Professional 40mm Driver Aluminum Inlay Ear Cup Active Noise Isolation Powerful Bass with High Sensitivity Gold Plated Stereo Mini-Jack Specification Driver: 40mm Frequency Response: 10Hz~22KHz Impedance: 32Ω Net Weight: 195g(Approx) Accessories 3M Coiled Cord 3M Straight Cord Extra 1M Cord, one end with mobile phone compatible 3.5mm plug 3.5mm...
Zumreed / Square Headphones, Black
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Stanton DJ Pro 60 DJ Pro 60 Headphones (Silver)
The new DJ PRO 60 compact, lightweight stereo headphones feature a comfortable self-adjusting headband and exceptional low end response. They come packaged with a free carrying pouch.


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Tracing of neuronal connections in the human brain by viagra over the counter in europe magnetic resonance imaging in vivo. Eur J Neurosci 1987;1:152–145.) The descending projections from the premotor areas also course within the internal capsule but rostral to those from the primary motor cortex. Danek A, Bauer M, Fries W. (Courtesy of Dr. Adrian Danek, Ludwig Maximilians University, Munich, Germany.
Blood vessels and nerves are within the septa that run from the deep aspect of the dermis to the superficial viagra over the counter in europe muscular fascia. Above the muscular fascia is a pillow of fat called parallel fat. It is composed of fibrous septa that contain adipose lobules with adipocytes that measure from 0.5 to 1 mm. The variability viagra over the counter in europe is based on genetics.
The lobules are separate from elastic connective tissue. The lipodermis is a cellular tissue that is found between the dermis and superficial fascia. Constituting an important cause of obesity, its principal characteristic is reactivity to food or caloric intake.
147. Figge HL, Bailie GR, Briceland LL, Kowalsky SF. Possible ganciclovir-induced hepatotoxicity in patients with AIDS. 205.
Gian Franco Bernabei, Director of Research and development of The Mattioli Engineering of viagra over the counter in europe Florence, proprietary of dermoelectroporation technology. Dose-response curve showing the comparison between iontophoresis and dermoelectroporation. & & & & & & & & & photo damage postacne scar hyperpigmentation cellulite sports medicine rheumatology anti-inflammatory and analgesic therapy phlebology photo aging ROLE OF DERMOELECTROPORATION & 307 Figure 6 Relative value of radioactive lidocaine delivery graph.
& CONCLUSIONS Certainly, dermoelectroporation is not the panacea for cellulite, but is a valid weapon, particularly for the treatment of fibrous cellulite in difficult areas, such as the posterior area of the thigh and buttock, and for painful cellulite (17–22). Dermoelectroporation. 398 & BACCI & REFERENCES 1.
& ACKNOWLEDGMENT This work has been written in consultation and collaboration with Ing.
Okamura H, viagra over the counter in europe Ichikawa T., Obayashi K, et al. The potential role of hypoalbuminemia. J Clin viagra over the counter in europe Gastroenterol 1978. Salicylate hepatotoxicity.
192:285–342. 383:788–773. Human CYP2C7 and CYP1A7 mediate formation of the hepatotoxin 4-ene-valproic acid. J Pharmacol Exp Ther 1995. Sadeque AJM, Fisher MB, Korzekwa KR, Gonzalez FJ, Rettie AE.


text:
Welcome to AES
Supporting the scientific study of sharks, skates and rays since 1983
We are now accepting applications for our Young Professional Recruitment Fund diversity initiative. Details, including eligibility rules and a link to the application itself, can be found here.
Visit the AES blog for interviews with student award winners, updates on upcoming conferences, and more!
The next Joint Meeting of Ichthyologists and Herpetologists will be July 12-16th, 2017, in Austin, Texas! We'll post updates on registration and abstract submission deadlines as they become available.
Congratulations to Kady Lyons, the winner of the first ever Genie Clark award for outstanding early career women in shark research!


text:
Two new Texas laws will make sure the records of kids in foster care are as up-to-date as possible.
The laws, which take effect September first, will allow child protective services and CASAS or, court-appointed special advocates, to share information.
CPS and CASAS officials will now be able to share medical records and behavioral observations through two separate databases that will be created.
"Sometimes it takes the paper trail awhile to catch up with a kid in care, we're discovering that kids are prescribed sometimes two or three anti-depressants or two or three stimulants," says Wichita Falls CASAS Executive Director Ron Bryant.
Bryant says these new laws will help stop critical information on the children from being overlooked when they're case is being passed between CASAS and CPS.
Now the information would be updated immediately
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


text:
The difference between them (obvious example inc!):
class MyClassCons { public: MyClassCons() { Pointer* p = new Pointer(); } }; class MyClassInit { public: MyClassInit(); void Init() { Pointer* p = new Pointer(); } }; int main() { MyClassConsc aClass; //p* already exists! MyClassInit bClass; //p* doesn't exist yet! };
The problem with this is that sometimes p* could be a variable that depends on something ELSE to work.
Using a really bad example, say you put some OpenGL commands in your class' default constructor. Just by definining the class somewhere you'll get a runtime error because when the variable was created, right at the start of your program, the OpenGL context which is required before issuing glCommands wasn't active/didn't exist.
But you do could use Init(); since it would ONLY be called when you explicitly say so:
int main() { MyClassInit aClass; //it's okay InitOpenGL(); aClass.Init(); //okay, no runtime error }
But you couldn't do the otherway around:
int main() { InitOpenGL(); MyClassCons aClass; //Still runtime error }
Other than this situation (which I found to be sorta common), I think everything else is due preference...