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Skip to comments.CLINTON THROWS BACHELOR PARTY FOR MEZVINKSY
Posted on 07/31/2010 2:04:26 AM PDT by tlb
Rhinebeck, NY - Bill Clinton threw a wild bachelor party last night for his future son-in-law, Marc Mezvinsky. Chelsea Clinton wasnt happy.
Bill Clinton insisted on throwing a bachelor party for his future son-in-law, over the strong objections of his beautiful daughter, Chelsea. But when Bill wants something, Bill gets it. And what he wanted was girls, girls, girls!
The former President brought in seventy-five strippers, pole dancers, and contortionists to the whipped-cream themed party held for Marc Mezvinsky at the Veranda House in Rhinebeck. Marc was reluctant, but Bill told him, Youre a Clinton now son, so you have to embrace the Clinton traditions.
Mezvinsky informed Bill that Chelsea was taking his last name, Shes dropping the Clinton entirely, sir. A naked Bill Clinton stood up, dropped the stripper off his lap and punched Mezvinsky in the face, The hell she is! Shes never taking your name, unless you run for President or she runs for President, then shell take your name, but thats just because the moron voters of America like it that way. Shell always be a Clinton. Now go get me some more grain alcohol
Clinton did a fuzzy navel jell-o shot off a half-naked bartender, but she scolded him. My navel isnt that low, Mr. President.
Al Gore showed up at the Bachelor Party with a gaggle of massage therapists. During the party Gore had several happy ending massages. He also had happy ending pole-dances, a happy ending game of pool and a happy ending coat-check. As a gift to the groom, Gore wanted to personally give Mezvinsky a happy ending, but Mezvinsky was too busy trying to keep Gina Gershon from pulling his pants down. Gershon was at the party as a favor to Bill.
Surprisingly, Hillary Clinton decided to attend. Why should Bill and Marc have all the fun? Hillary, dressed as a stripper, was rolled out in a cage. She did a burlesque striptease for her future son-in-law, who tried to look away, but James Carville held his head in place. Look at your mother-in-law. You try and tell me that aint the next President of the United States!
In an incoherent and rambling speech, Bill Clinton said that he was giving Marc a nickname. Everyone calls me Bubba, so I think its only fitting that Marc have a similar name. From now on youll be known as Boo-Boo. Well be Bubba and Boo-Boo. Now go get me some weed!
The lowlight of the night was when George H.W. Bush and George W. Bush showed up and did The Full Monty for the crowd. But Hillary couldnt take her eyes off W. I think Im in love. Either that or Im in hell. After Bill passed out cigars to all the guys, the party quickly got out of hand and
well, WWN cant reveal everything that happened but a lot of girls are going to be saving their blue dresses.
Click on the link for the awful pictures.
Is this supposed to be humorous?
"I defy you to find this story in the New York Times."
Well, it is a funny SPOOF.
Some of it, however, would be believable, considering it is about Clinton.
It is a joke.
This story is as fake as Slick Willy's tears at Ron Brown's funeral.
Someone called me on the phone to tell me this. I will hope that for that person's sake, that person had only read the headline.
>>> It is a joke.
How dare you impugn Weekly World News' reputation for serious investigative reporting.
I hope the son in law wasn't asked to wear a blue dress, jeez son grow a pair and tell Bill to suck an egg..Whats next you are a clinton now here is an intern?
Maybe a joke, but the mental images it made werent funny.
At least he showed some Presidential restraint.
The only thing missing is a few drunken, party-crashing Kennedys.
Right there, I knew it was a spoof.
Yes, obviously:
. . . his beautiful daughter, Chelsea.
(quote from the article)
I defy you to find the "beautiful Chelsea", referenced in the story.
It ain't her fault, I know, but that girl is butt ugly and all the damned Max Factor in the world can't fix it.
Hillary and Hubb were not on the 100 Most Beautiful People list...and we see the result.
And I resent the hell out of the liberal media trying to convince me that I'm not seeing what I damn well know I'm seeing.
And I also know well that beauty is skin deep, but knowing who her parents are (and I ain't putting Hubb in that category), I suspect her ugly goes to the bone.
I love it!
"but Mezvinsky was too busy trying to keep Gina Gershon from pulling his pants down"
I always thought Gina Gershon was a man. Now I see that I was right.
Rhetorical question, obviously. The last paragraph is particularly unfunny.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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Begin Your Search
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Read stories from the world's greatest wine trails.
More About This Wine
About Veuve Clicquot Ponsardin
Veuve Clicquot Ponsardin was founded in 1772 by Philippe Clicquot-Muiron, but it was his daughter-in-law, Barbe-Nicole Ponsardin who would catapult it to greatness. The empire that Madam Clicquot built now includes 360 hectares of vines, including 12 of the 17 Grand Crus in Champagne.
2004 Veuve Clicquot Ponsardin La Grande Dame
Producer: Veuve Clicquot Ponsardin
Style: Sparkling
Grape Type: Champagne Blend
Origin: France
Region: Champagne
93 Points | Stephen Tanzer's IWC - November/December 2013
(made from fruit grown in eight different grand crus, mostly Verzenay and Avize; lot 5122815): Vivid gold. Heady aromas of orange, white peach and smoky minerals, with a note of buttered toast adding depth. Densely packed citrus and pit fruit flavors show chewy texture and a bright mineral quality that adds vivacity. Rich but lively and precise, finishing very long, with notes of candied fig and toasty lees.

subset: commoncrawl


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Brotherly Love: Famous Visitor Inspires County's Food DriveLast year, Pope Francis stayed at St. Charles Borromeo seminary in Lower Merion for a night and Montgomery County officials wanted to give the visiting pontiff a tangible thank-you.
Philabundance Launches Month-Long Fundraiser In Honor Of Hunger Action MonthA local organization is using Hunger Action Month to try and feed as many mouths as they can throughout the Delaware Valley.
Need To Fill Food Pantries Locally During Kid's Summer BreakMore than 300,000 children in our area lose their school breakfast and lunch meals during summer break.
SEPTA, Philabundance Team Up To Stop HungerSepta's teaming up with Philabundance for its 8th annual Stop Hunger at Your Station food drive, which starts Monday. The two-week campaign aims to help thousands of people in the Delaware Valley.
'Stop Hunger' Food Drive Helps Kids Get Meals They Need On Summer BreakSEPTA and Philabundance rallied against hunger at Dilworth Park, outside City Hall, aboard a "Stop Hunger at Your Station" food drive.
Program Offered By Philabundance Teaches Culinary Skills To Low-Income AdultsThe program is offered to low-income adults.
Philabundance Hopes To 'Spread The Love' Through Peanut Butter DonationsPhilabundance has launched their annual February campaign called 'Spread the Love' in hopes of getting the public to donate peanut butter and money to the nonprofit.
SEPTA Keeps Food Drive Rolling One More DayThe "Stop Hunger at Your Station" campaign was supposed to end this past Friday, but SEPTA hopes a visit to the grocery store over the weekend for passengers leads to extra donations for Philabundance today.
Area Bank Donates $40,000 To Phillies' Seasonal Anti-Hunger CampaignThis year's "Phans Feeding Families" campaign is getting a financial jumpstart from Citizens Bank.
Hundreds of Peco Workers Put Energy Back Into Community For National Volunteer WeekPeco employees were inside the Philabundance warehouse in South Philadelphia today, helping to box food to be distributed to low-income seniors in need.
A New Face In The Fight Against HungerPhilabundance will welcome Glenn Bergman as Executive Director in June.
Top Local Organizations For Holiday Donations In PhiladelphiaThe end of the year brings with it numerous reasons for celebration and generosity. Here are the top local organizations to donate your money or time to this upcoming holiday season.


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Southwest Corner Cluster
Description: This dynamic group collaborates, combines, and coordinates their resources, knowledge, and experience in order to enhance capacity for:
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As he navigated his way around Miami's campus, Mark Richt did a double take.
And then the new Hurricanes coach — a former quarterback here — wondered if he was lost.
"I thought I was on the right street, but every time I looked to the right, there was a building I'd never seen before," said Richt, sporting a dark orange and green tie and Miami's trademark 'U' logo on his lapel. "I said 'I hope I see the baseball stadium soon,' and eventually I did. Then I knew where I was."
It turns out that even when home looks a little different, it's always familiar. And that was one of the major themes Friday morning when Richt, who played at Miami...


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New World Symphony presents Modest Mussorgsky's musical journey through an art exhibition while animated vignettes play
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Celebrities glammed it up last night in Los Angeles for theLACMA 2015 Art+Film gala. The event honored James Turrell and Alejandro Inarritu and was attended by Hollywood's hottest, including pregnant reality star Kim Kardashian! Kim had just spent the night before celebrating her mom's birthday until the wee hours of the morning! Mrs. West went with an all-sheer and lace black suit that showed off every bit of her baby bump..and then some!
Is Usher Married?
It looks like Usher tied the knot for the second time! He got engaged back in January. Now, new photos suggests that Usher and Grace have made it official and are married.
Usher Is Engaged!
OMG. I know Usher and Tameka Foster have been over for years, but I didn't know he was dating anyone else. It turns out he's been dating Grace Miguel since his split. Now, the two are ready to make it official! RELATED: Usher shares his "best mistake" with O magazine.
Usher Confesses His "Best Mistake" In O Magazine
The September issue of O magazine hit newsstands yesterday, and it's chock-full of interesting stuff! Oprah rocks a cat suit, fall fashion trends are reviewed, and even Usher sat down with the magazine for a heart-to-heart! If the interview excerpts are any indication, Usher was very candid in his interview. Those are the BEST ones to read. RELATED: Oprah covers O magazine in a cat suit.
Usher & Shakira Playful Pair On The Red Carpet For 'The Voice'
'AGT' wasn't the only reality TV show that had a red carpet event. So did 'The Voice'! Shakira and Usher, who have served as mentors for two seasons, had fun on the red carpet together. Veteran mentors Adam Levine and Blake Shelton were also there, along with host Carson Daly.
The Verdict Is In For USHER'S Stepson's Killer
The verdict is in! In the summer of 2012 Usher's stepson – Kile Glover – was run over by a jetski while tubing on a Georgia lake.
After spending some time on life support his family made the difficult decision to remove him from life support, and he tragically died at just 11 years old. Now, nearly two years later, the man who was operating the jet ski has had his time in court, and was found guilty of five counts including; homicide by vessel, reckless operation, and unlawful operation of a personal watercraft.
While it was no doubt a sad day for Usher and his family, we're sure that now that a verdict has been reached they can begin the healing process.
Photos via WENN.
USHER Kicking Off 2014 With Adventure!
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Usher posted these AMAZING pics to Instagram. These aren't all of them, so head over to his account to see them all. He and Shakira are both returning to 'The Voice' this winter, too. Usher has a lot going on in 2014. Will you be watching him as a mentor?
Photos Courtesy of Usher
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All hotels in Opua, New Zealand
1 room, 2 adults
3 Richardson Rd West, Opua, 0290, New Zealand, 1-877-214-4288
Cliff Edge by the Sea - Opua
Lowest price$156
Cliff Edge by the Sea is a luxury 5-star beach Opua lodge, 3.5 mi (5.7 km) from Paihia Beach and 3.7 mi (6 km) from Paihia Wharf. Waitangi Treaty Grounds and Waitangi Golf Club are also within 6 mi (10 km).
Along with free full breakfast, this lodge offers a private beach and a restaurant.
Along with free full breakfast, this lodge offers a private beach and a restaurant.
Multilingual staff can provide tour/ticket assistance. Free WiFi is available.
See all 11 Venere.com reviews
Delicious food
Awesome vibe
Great room
Beautiful beach
TripAdvisor Traveller Rating: 4.5
From 86 reviews
Cliff Edge by the Sea - Opua
Hotel Info: 1-877-214-4288from $156
- Tui One Bedroom Apartment Ocean Views
- Okiato Ocean Views
- Waikare Ocean Views
- Kowhai
- Waitangi Ocean Views
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 4 rooms
- Check-in time 2 PM-8 PM
- Check-out time is 11 AM
If you are planning to arrive after 8 PM please contact the property in advance using the information on the booking confirmation.
Airport shuttle service is available on request. Contact the property in advance to make arrangements.
Airport shuttle service is available on request. Contact the property in advance to make arrangements.
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
In the hotel
Food and drink
- Free full breakfast daily
- Restaurant
- Coffee/tea in a common area
- Tours/ticket assistance
- Dry cleaning/laundry service
- Multilingual staff
- Safe-deposit box at front desk
- Garden
- Picnic area
- Terrace
- Library
- Fireplace in lobby
- Television in common areas
In the room
Home comforts
- Ceiling fan
- Bathrobes
Sleep well
- Premium bedding
Things to enjoy
- Separate sitting area
- Balcony
Freshen up
- Private bathroom
- Bathtub or shower
- Free toiletries
- Hair dryer
Be entertained
- Flat-screen TV
- IPod docking station
- DVD player
Stay connected
- Free WiFi
- Phone
Special features
- Bicycle rentals nearby
- Golf lessons available nearby
- Golfing nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Parasailing nearby
- Sailing nearby
- Scuba diving nearby
- Skydiving nearby
- Snorkeling nearby
Cliff Edge by the Sea - Opua's small print
Also known as
- Cliff Edge Sea
- Cliff Edge Sea Lodge
- Cliff Edge Sea Lodge Opua
- Cliff Edge Sea Opua
- Cliff Edge By The Sea Bay Of Islands/Opua, New Zealand
For transfers, guests must contact the property 24 hours prior to arrival at the number on the booking confirmation.
Optional extras
Rollaway beds are available for NZD 50 per night
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Excellent 4.5 /5 from 11 reviews
Cliff Edge by the Sea - Opua
The dinner at the hotel was excellent and the view is amazing!!!


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Independence Day: Resurgence
Duration | Rating | Year : 119min | PG13 | 2016Two decades after the first Independence Day invasion, Earth is faced with a new extra-Solar threat. But will mankind's new space defenses be enough?
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Star Trek Beyond
Duration | Rating | Year : 120min | PG13 | 2016The USS Enterprise crew explores the furthest reaches of uncharted space, where they encounter a new ruthless enemy who puts them and everything the Federation stands for to the test.
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Duration | Rating | Year : 123min | PG13 | 2016As an Orc horde invades the planet Azeroth using a magic portal, a few human heroes and dissenting Orcs must attempt to stop the true evil behind this war.
Dare To Be Wild
Duration | Rating | Year : 100min | PG | 2015Irishwoman Mary Reynold's journey from rank outsider to winner of a Gold Medal at the Chelsea Flower Show.
Free State of Jones
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In this visually compelling look at our changing environment by Jeannie Baker, illustrator of the critically-acclaimed Mirror and Where the Forest Meets the Sea, a mother and baby look through a window at a view of wilderness and sky as far as the eye can see. With each page, the boy grows and the scene changes. At first, in a clear patch of forest, a single house appears. A few years pass and there is a village in the distance...When the boy is twenty, will he recognize the view from his window? Illustrated with elaborate and gorgeous collage constructions, Window is a wordless picture book that speaks volumes.
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text: Halloween Pumpkin Bath Wrap code BUYMORE15 come in Pumpkin (pictured), Black Cat or Halloween Monster. Flag this deal What's the matter? Choose a reason Dead deal Duplicate Bad link Spam Inaccurate No value Alive again Edit deal Christine Sep 26, 2012 awww absolutely adorable! and 50% off =) Reply Load More Comments


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Skip to comments.After Walker victory, Indiana governor suggests public unions should go
Posted on 06/10/2012 12:46:31 PM PDT by South40
On the heels of Wisconsin Gov. Scott Walker's history-making recall victory, the governor of nearby Indiana with his own record of curtailing union benefits suggested public-sector unions are past their prime and should be abolished.
"I think, really, government works better without them," Indiana Gov. Mitch Daniels told "Fox News Sunday," when asked whether public-worker unions should even exist.
Daniels had cracked down on collective bargaining for state workers as soon as he took office in 2005, six years before Walker and his GOP allies in the state legislature started down the same path -- triggering a backlash that forced him to stand for election this past Tuesday. Walker made history as the first governor to survive the recall test, beating Democrat Tom Barrett.
(Excerpt) Read more at foxnews.com ...
Less talk... JUST DO IT !
I'm not sure they are even constitutional.
When has that silly old Constitution ever meant, let alone stopped a libtard from doing whatever they damn well please.
"Less talk... JUST DO IT !"
No politician can "do it" without sufficient power. That power comes from the people. The Tea Party showed the way in 2010. If there is a groundswell of public opinion in favour of — whatever —, then the politicians will become motivated and empowered to do that.
Consider a counter-example. Obama and Obamacare. Obama spent a lot of political capital ramming Obamacare through. Now, it seems that about 2/3 of the people don't support Obamacare, and it might be quashed by the SCOTUS.
If any governor were to eliminate public-sector unions, without broad public support; they (the unions) would just rise again like zombies.
The reason usually given for a recall is so a corrupt politician can be quickly removed. Since those days the federal government has actually removed many more top level politicians for crime than all the states with recall have removed.
I think it used to be the case that the federales didn't have an anti-corruption law to use ~ which they do now.
I find recall to be rather contrary to the American process.
That sound you just heard was the blast of a thousand DUmmie heads exploding.
The Libs constitution is in Pelosi's terrarium. It's kept alive with an endless supply of Unicorn manure and rainbow sunshine.
Be well and have a joy joy day.
Agreed! No public servants should be unionized, especially when they have the power to strike!
did the Indiana Gov learn his position at the Bilderberg meeting he just had attended?
Well. THEY are probably constitutional, but their so-called "contracts" are obviously not.
Glad you brought up the Lansing thing. The 'flashlight' comment by that union thug is interesting. http://www.myfoxphoenix.com/story/18663819/flashlight-found-in-car ~ Some one has begun making up FLASHLIGHT BOMBS and leaving them around Phoenix.
Mitch has been after the state unions for many years. Maybe he passed on tips to the Bilderberger commando teams eh!
Government Employees are the largest Lobbyist Group in the USA.
We need to curtail Government Employee power and influence by removing Unions from government.
Right now most of our elected legislators and executives are scared to death of the Government Employee Lobby.
He wants to impose Wal Martial law.
And that's the primary reason I oppose term limits. A bunch of noob legislators are no match for entrenched government employee union bosses. The bigger the government, the more bureaucrats, the stronger the unions, the more powerful they become. Without a serious reduction in the size of government...and complete elimination of government unions, there should be no discussion of term limits.
There is no reason why any government employee should be in a union.
You don't think there's broad public support? Scott walker's convincing victory, plus landslide victories for reform in San Jose and San Diego say otherwise.
Posted in post number 10. It lays out a great case against public sector unions.
For what sane reason are public worker unions even needed?
Other than simply siphon off money from the public treasury to fund their Democrat allies, they have no other reason to exist but to exert pressure 'collective-bargaining' and extort from the public treasury.
At least two past presidents, both dems, I think, Wilson? T. Roosevelt? and FDR spoke unequivocally about the unacceptability of "public emmployee" unions.
We all know where Ronald Reagan stood. And we also all know where The Great Destroyer of America and his party stand.
I am searching for the links and will post their exact words later.
Coincidentally, Fox News Sunday with Chris Wallace was on, Fox, with "guests" only representing the "Public" Employees Thug Unions only. It will be repeated later today at 11 pm PDT.
Recommended watching, because Chris plays the devil's advocate in favor of the unions with much more sympathetic enthusiasm, as hard as he attempts not to.
Check out freeper Elle Bee's most excellent post #5.
HOORAY Mitch Daniels! No public unions and a lot less public workers in a much smaller government.
DISMANTLE UNaccountable government bureaucracies (socialism). Let the workers find a job doing something productive...not something "progressive".
FDR thought government worked better without them.
If it's good for the fedgov, it's good for the stategov.
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See Foreign Fields perform in our studio
Brian Holl, left, and Eric Hillman, center, are West Bend natives who perform as the band Foreign Fields. Along with touring cello player Hitoshi Yamaguchi, right, and two other touring musicians, Foreign Fields performed at the Journal Sentinel offices Friday for the Tap Pre-Show music video series. Photo by John Klein. »Read Full Blog Post
Discovery World closes for the day because of snow
The snow made them do it. Discovery World, 500 N. Harbor Drive, is closing at 2 p.m. today because of the weather, according to its Facebook page. They expect to be open at 9 a.m. tomorrow. Just in case, call (414) 765-9966 or see www.discoveryworld.org »Read Full Article
Someone mashed up Nine Inch Nails and Carly Rae Jepsen...and it sounds better than it should
Trent Reznor shocked fans by announcing a new collaboration with cutesy pop singer Carly Rae Jepsen. Not really; someone just mashed up their songs. But maybe they should tour together? No, no they should not. Journal Sentinel photo by Michele Jokinen. »Read Full Blog Post
Registration open for Braise's annual morel hunt
Someday spring will come, and then it will be time for the annual morel mushroom hunt organized by chef David Swanson's Braise. But you'll have to register for it now.
Registration for the event May 11 opened Tuesday morning, and it always sells out early. It's limited to 20 people. »Read Full Blog Post
Japandroids among new Milwaukee concert announcements
Canadian rock duo Japandroids, which released one of 2012's most acclaimed albums, the succinct and aggressive "Celebration Rock," is coming to Turner Hall Ballroom, 1040 N. 4th St., on May 27.
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On Tap Today: Northern Ireland, through photos and music
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"Look Behind You!" begins at 7 p.m. at the UWM Hefter Conference Center. »Read Full Blog Post


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BiologyThis species is poorly known, occurring at the upper continental slope in tropical waters, at depths of 286500 m. Stomach contents of 8 individuals include an unidentified organic material, partially digested shrimplike crustaceans, and a small decapod shrimp; no fish or cephalopod remains were apparent in the samples. Larger individuals had small puncture marks and elongated parallel cuts on their backs and tails suggestive of combat injuries from the rostra of other sawsharks. Unknown litter size. Caught and discarded as bycatch by offshore shrimp trawlers and other deepwater fisheries operations off Mozambique (Ref. 87357).


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Follow HitFix Follow @hitfix
Billy Cosby made the best 'Tonight Show' entrance ever last night
The doctor is in!
By Liana Maeby @lianamaeby | Thursday, Nov 14, 2013 1:57 PM
"Bill, over here! Over here, Bill, over here! Turn around! Bill, you're going the wrong way. Please turn around, I'm over here. Oh my god, I will never understand comedy." - What I'm surprised Jay Leno didn't say.
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mark (guest)Jay Leno doesn't understand comedy? This was a bit and Jay Leno needed to be the straight man.. I think the poster of the video might not understand comedy.November 15, 2013 at 5:12AM ESTReply to CommentLike (10)Latest Likes:10 Anonymous
Hannover (guest)Pretty sure that wasn't *planned* comedy. You don't trip off a step when you know what you're doing. He looked genuinely lost. I like Bill Cosby but he looked feeble.November 16, 2013 at 1:58PM ESTReply to CommentLike (4)Latest Likes:4 Anonymous
JBnID (guest)Many years ago, Bill Cosby said the way to be funny was to be unexpected.November 22, 2013 at 11:24PM ESTReply to Comment
Ned (guest)I thought it was stupid.
Was he imitating a person with Altzheimer's disease or does he have it?I don't find imitating that to be humorous. When you have a relative suffering from it, it's NOT amusing.November 24, 2013 at 10:18PM ESTReply to Comment
marci seriously doubt bill cosby, of all people, was trying to be funny at the expense of someone with dementia. i've watched bill since i was a kid in the 70s and have never known him to be hurtful with his comedy. Just his take on an old gag.November 26, 2013 at 1:57PM EST
Again, having a relative suffering with this is NOT AMUSING or HUMOROUS. It's devastating and frustrating. It is NOT funny. I too am familiar with Bill Cosby from years ago and was shocked at his latest brand of "humor". If this is the best he can do, he needs find another way to make a living. He was OFFENSIVE.
Next time will he mock Autistic people? Or maybe a person that suffered a stroke is partially paralyized and drools would that be "funny" too?
Honestly MARC, these situations are NOT funny. Trying to be "humorous" at the expense of others with a serious issue they can't help is NEVER funny.November 27, 2013 at 2:54AM EST
DaveIf he were younger it probably would not have been thought of as making fun of Alzheimer's, but because he is Older it is automatically associated with Alzheimer's? Bill Cosby is one of the classiest guys in comedy, if he was playing it up as being a goofball, I would buy that. It is just not his style to make fun of the unfortunate, shame on you for thinking that.....November 27, 2013 at 12:41PM EST
RobertDr. Cosby has vision problems. He was making fun of the fact that he can't see very well. Quit playing the victim card.November 28, 2013 at 9:54PM ESTLike (7)Latest Likes:7 Anonymous
MiguelitoYou said "When you have a relative suffering from it, it's NOT amusing". So, if you did not have a relative suffering "from it", you would have been ROTFL?? Selfish, indeedDecember 2, 2013 at 5:44AM EST
marcNED, everyone has a relative suffering from one ailment or another, so please get off the high horse. I'm sure nobody - at least those with empathy - is here to insult you or your family member. Bill Cosby has never been one to play the insult card. He was likely mocking HIMSELF and how age has affected his own cognitive abilities. Compared with today's "anything goes" style of comedy in which people with serious illnesses, disorders and infirmities are mocked ruthlessly (which I find abhorrent), I'd say Bill's gag was completely innocuous.December 3, 2013 at 9:07AM ESTLike (4)Latest Likes:4 Anonymous
shelia dykesi am 60 years young, and saw the show and bill cosby. I have watched his shows and is voices in his comics, but this inded I found offensive, I think he owes an apology to the ppl of America suffering from dementia and alzheimers.December 4, 2013 at 5:19PM EST
marcWell then let's just all stop laughing at ourselves and the human condition, shall we? Bill's gentle poke at humanity's (and possibly his own) foibles were nowhere near offensive. Doing something like pretending to burn down the studio by forgetting an unattended coffee pot on the stove would be offensive and deserving of harsh criticism.
Instead of laughing at ourselves, we'll find every possible excuse to be offended and spend our lives in humorless misery since, God forbid, someone with heightened sensitivities may get their feelings hurt and jokes will be reduced to "A person perambulated down the street and nothing happened." Hilarious.
To find common ground for humor, however, a line must be drawn. That line existed once, but overly-insensitive contemporary humor has erased it and ushered in the age of overly-sensitive political correctness. It's happened in other facets of modern life, such as politics. Warring extremists have demolished the buffer that moderation once provided. Today, anyone who tries to be moderate is seen as wishy-washy or a flip-flopper. We desperately need that middle ground to soundly determine what is and what is not acceptable to us as a society.December 4, 2013 at 6:51PM EST
FirstLoveMarc, well said.You are a person with great insight and adeep understanding of the condition, Human. I like your words and commend your reality.December 9, 2013 at 6:54PM EST
angelcould someone play the part where dr. cosby said he was imitating a person with dementia/alzheimers. if it doesn't exist then don't suppose. did you know that he makes fun of himself and his eyes deteriorating... that's what he referenced on another show not any disease but his personal ailmentsDecember 10, 2013 at 9:55AM EST
MelinJeez people. He was making a joke at HIS OWN expense about the fact the the man is almost totally blind. It had nothing to do with Alzheimer's so please get that chip off your shoulder. If you're that sensitive maybe you need to be on the top of a mountain, in a Buble with no access to the outside world so nothing can possibly be do e to effect your precious feelings.December 27, 2013 at 11:44PM EST
ohsnap (guest)His show is entitled 'not finished yet'. Seems he was playing to that. OR he really is losing it. But since Jay said he had seen the DVD and it was funny, it seems more likely the former.November 24, 2013 at 11:09PM ESTReply to Comment
Jpeezy (guest)Bill Cosby has a degenerative eye disorder. He is going blind. He wasn't attempting humor. He honestly cannot see. Get over yourselves.November 26, 2013 at 2:08PM ESTReply to CommentLike (8)Latest Likes:8 Anonymous
Sarah (guest)Shame on YOU, Dave.
The age you are viewing this ridicule has nothing to do with the fact that LAUGHING at people who have a serious disability with NO CURE whether it be Altzheimers, Autism, a stroke, going blind, hard of hearing is NOT HUMOR MATERIAL!
It is NOT "classy" to ridicule these people. People change ... perhaps Bill COsby is desperate for attention and is reaching to the bottom of the barrel for material to revive his career. It happens! Cheap laughs at the EXPENSE of OTHERS is NOT "classy" humor nor does a "classy" person use that as script.
When you are around people that you LOVE and see someone like Bill Cosby USING their disability for HUMOR it is NOT funny. It is totally offensive. Shame on YOU, Dave for being as insensitive as Bill Cosby.
Dave, you have no idea how heartbreaking it is to see a loved one LIVE Bill Cosby's "HUMOR". This is their REAL life. It's not a joke. Shame on YOU for making up excuses to LAUGH at people who live challenging lives that truly drain those who love them. It is pure LOVE that carries us through caring for them. We remember who they USED to be and find the patience. Some days you really have to dig deep. It's 24/7 CHALLENGE. It's not a 10 minute JOKE for ratings or laughs or career revivial.
Shame shame on YOU, Dave. Whether the joker or audiance is YOUNG or OLD, LAUGHING and making a JOKE out of these people's hardship is unacceptable! It is NOT humor material. Anyone that finds Bill Cosby funny or even amusing is sadistic and insensitive to others that deal with people who HAVE what Bill Cosby LAUGHS at. It's down right CRUEL.
Don't fret Dave. I guarantee you, in state homes and some private homes, OTHERS LAUGH and physically abuse these defenseless people. I'm sure they would relate and ENJOY sadistic humor. When you LAUGH at something sad and tragic, it is more difficult to take the tragedy seriously. This kind of humor desensitizes a person. It's an old low down trick that has been around for ages. It's clearly still effective since you have no qualms in defending it.
Don't you find it odd how some fitness person, Maria Kang gets kicked off FaceBook for ridiculing FAT people and yet YOU LAUGH at people who have NO CONTROL over what is happening to them and would NEVER want to have that be their fate. Apparently this Maria Kang ridiculed obese women that wore plus sizes and hear YOU are defending Bill Cosby LAUGHING at others who truly have NO CONTROL on what is happening to them.Write a comment...November 27, 2013 at 5:02PM ESTReply to Comment
SilentKnightDEA God, shut up and quit your whining. I have had two (2) Grandmothers go through dementia, alzhiemer's, and on into death. You seem to forget people like Michael J. Fox, who makes light of his condition, so that IT DOESN'T CONTROL HIM. In America there is another thing you forget, you have the Right to be offended by ever little slight you perceive, but the rest of us have the Right to ignore tour stupidity. I, personally, don't care for Cosby. But I am not so insecure in myself that I have to try and find fault where none exists.November 28, 2013 at 2:50AM EST
I do NOT believe anything you wrote. Anyone that expereinces what you claim doesn't find it "funny". Michael J. Fox is an established celebrity. He is doing the best he can. The disease DOES control him to a certain degree. He can deny that but it speaks for itself unless they find a cure for Parkinsons disease. He is not in the later stages.
You also have to right to be cavalier and indifferent and you are demonstrating that.
"Right to ignore tour stupidity."
I see you have run out of civil debate so PERSONAL ATTACK is what you are left with.
"I, personally, don't care for Cosby. But I am not so insecure in myself that I have to try and find fault where none exists."
I am not "insecure" and again PERSONAL ATTACKS do NOT give YOU credibility. I don't care if you like Bill Cosby or not. Your FEELINGS towards him is not the issue.November 29, 2013 at 2:30AM EST
Kg (guest)As an RN who knows nothing about Bill Cosby or his health problems, (so I'm making an educated guess here) this really looks like a bona fide physical or cognitive problem to me. This didn't feel like comedy to me. I saw him on Dr Phil about five years ago, and could tell his mental processes were wandering. I wish him the best.November 28, 2013 at 6:45AM ESTReply to Comment
Ginny Mayer (guest)God grief, you all are wearing the subject out. Take his humor or leave it. I am affected every day, every hour, by dealing with a much loved one with dementia. Let it go. Like it, don't like it. Or just maybe give him the benefit of the doubt. You can always find something that offends you but why look for those? Move on and be happy.November 30, 2013 at 12:09AM ESTReply to CommentLike (7)Latest Likes:7 Anonymous
Sowat (guest)People are losing it on this site, it's just comedy, not meant to offend, not meant to degrade. Just plain ole comedy. We do it in different ways, not always understood. Why are we pitching a fit because of something we are not sure of, it isn't that serious in a very serious world........man! (but it wasn't funny) but it was harmless.December 1, 2013 at 12:05AM ESTReply to Comment
Sowat cormdound (guest)Write a comment...People are losing it on this site, it's just comedy, not meant to offend, not meant to degrade. Just plain ole comedy. We do it in different ways, not always understood. Why are we pitching a fit because of something we are not sure of, it isn't that serious in a very serious world........man! (but it wasn't funny) but it was harmless.December 1, 2013 at 12:07AM ESTReply to Comment
Sharon (guest)I thought Bill Cosby was a little tipsy---Bill did clearly didn't see the step---the show could have had a different ending if Jay hadn't gone after him---December 1, 2013 at 10:40AM ESTReply to Comment
Sharon (guest)Bill Cosby clearly didn't see the step down and I thought he was just a little too tipsy----if Bill had lost his footage---the show could have had a different ending---Bill is great---no other guest has made such an entrance---but Thank God he didn't fall! I think that would have really would have embarrassed Bill!December 1, 2013 at 10:42AM ESTReply to Comment
Heather (guest)Marc,
Laugh away at people who are disabled and truly can't help themselves. It will make YOU feel superior for a few minutes. I've noticed that insecure people get off on LAUGHING at OTHERS. I draw the line when the person has NO CONTROL over their disability - whether they are going blind (how horrible), altzheimers, parkinsons, downs syndrome etc..
Go ahead Marc, LAUGH it up. Write some comedy scrips for it and post em here. Maybe this could be a new career for you but don't give up your day job yet.
Then again, with the haughty, narcissistic attitudes of too many out there you could be a real hit. Just think .... piles of money for laughing at people who'd rather NOT be the butt of your jokes. You'd fit right in with Hollyweird ... well as long as YOU agree with THEM, then they will "tolerate" you.
Run along Marc ...December 5, 2013 at 12:26AM ESTReply to Comment
Igor (guest)He's blind. These comments are insane.December 5, 2013 at 5:08AM ESTReply to Comment
vkatnyte (guest)you guys do realize if bill cosby was on here and read your comments he would've said "I have a doctorate.I'm old.I'm getting older. I put my hand out to the person I thought was an assistant on the show to help me but obviously he wasn't.Other folks wanted to shake my hand and say hi.So i embraced that..I have fans that appreciate me still and love me still because of my work,because of my stand and opinion on certain topics. If you think I offended you or feel wronged-fine. But you must understand- I don't care what you think,I've done the work, got to where I am from hard work-so in the most american way I can tell you,quite simply..fuck off."December 5, 2013 at 5:56PM ESTReply to Comment
VGS PURGEVKATNYTE u r the smartest man i know just from saying what u just said bill cosby would say exactly that you people wanna talk about my father bill cosby (father figure) but yet u haters arent on his level and probably never will be try being accused of rape try being 77 try being old u talk downers just know that bill cosby is the man and only the man and on more thing..........WE THE PEOPLEDecember 5, 2014 at 2:02PM EST
NICHOLAS (guest)Bill is losing his eyesight!! This is not a joke. He was thrown off as to where Jay would be standing. Watch this closely and it will be obvious that he cannot see, i.e. reaching for Jay's hand, sitting down, back to audience, etc. Same things were repeated on Jimmy Fallon show. OBSERVE, PEOPLE!!March 9, 2015 at 10:33AM ESTReply to Comment
Janice StrommelAnother observation. Look at all the pictures of Phylicia Rashad and Bill Cosby through the years. I find it very, very telling of a more than TV relationship. All pictures he is holding her hand, hugging her or kissing her in a lot of private settings. If pictures are worth a thousand words, look at how she looks at him in all of them, compare it to a casual versus intimate relationship, I come up with a very personal intimate one, she is practically drooling in some. Their body language is rather telling also. Am I alone in my observances?March 12, 2015 at 12:40AM EST


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|Paul Klee
|1879 - 1940
This artist has 251 artworks in the database. Add more!
Top owners of works by this artist
|Private collection
|195 artworks
|Städtische Galerie im Lenbachhaus - Munich
|(Germany - Munich)
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|Metropolitan Museum of Art - New York, NY
|(United States - New York)
|7 artworks
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|(United States - New York City)
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|San Francisco Museum of Modern Art
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Creative works made by this person are in the PUBLIC DOMAIN (not copyrighted).
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Revision Rhinoplasty Q&A
Symmetrical + Revision Rhinoplasty
Revision Rhinoplasty to Fix Both Aesthetic and Funtional Issues. Can It Be Performed Through a Closed Rhinoplasty? (photos)
I am considering a revision rhinoplasty where cartilage graft needs to be used to restore my distorted nose. As you can see, too much cartilage was... READ MORE
Do I need revision rhinoplasty? (photo)
I am two years post-op and I am considering a revision rhinoplasty. What needs to be done to my nose to achieve a more symmetrical desired result that... READ MORE
Symmetrical and droopy collumela? (photos)
When i was little i broke my nose , my cartilage was twisted and off to the left . I did my rhinoplasty surgery with medical insurance (free) at the... READ MORE
What is the Best Way to Attain Symmetry of Nasal Bones? (photo)
(Pic is post-op 5 weeks) I am aware that the lower-half of my nose is still swollen, but would like to ask some doctors for their expert advice on... READ MORE
Will Unilateral Osteotomy Straighten My Crooked Nose? (photo)
I had a septorhinoplasty a year and a half ago. My nose has looked crooked since then. It appears that the left side of my nose is concave and the... READ MORE
Can I have my nostrils brought downward and made to appear less flared? (Photo)
I've had a rhinoplasty done (for a straight bridge and a more triangular tip) but I still feel that my nose is not quite right. I compared my face to... READ MORE
I want to fix my nasal tip, make both sides symmetrical, make my scar less visible. Will I need more work than I think? (Photo)
Revision rhinoplasty. Im wanting to fix my nasal tip, make both sides symmetrical, make my scar less visible and have my nose brought in more (if... READ MORE
1 nostril collapsing after rhinoplasty. Can this be fixed symetrically?
Basically on side of my nose the cartilage is collapsing inwards. I can breathe fine but it looks bad. From the nostril crease towards the tip of my... READ MORE
What procedure would you recommend for my septum? (Photo)
What sort of procedure would you recommend to get rid of my septal curve and make it less bulbous and more defined and more symmetrical. Had a... READ MORE
Can my nose be made symmetrical, straight and narrow with revision septorhinoplasty?
I have had rhinoplasty to make my nose narrow. From that my nose was crooked. I had rhinoseptoplasty to straighten my nose, but it is still crooked. A... READ MORE
How soon can I get a revision? (photos)
I have beautiful results. Round, symmetrical, big and full. But they turned out smaller than I expected. I went under the muscle 425 HP. I am hoping... READ MORE
ScAred to undergo making collapsed nostril even again. (photos)
I have had a deviated septum fixed 15 yrs ago. Then rhinoplasty, then 2 revisions, and last one (6 years ago) to push up the columella..Post operation... READ MORE
Can my nostrils be corrected to a natural shape and what options do I have? (photos)
I had rhinoplasty 6 years ago, it has improved my nose so much from how it was before, but I am now unhappy with my nostrils as they are not... READ MORE
Revision rhinoplasty or cheek/jawline enhancement? (Photo)
I'm going around in circles!!! What do you doctors think I would benefit from the most? A revision rhinoplasty (following a non-cosmetic septoplasty)... READ MORE
What can I do about my nostrils and nose tip? (Photo)
I already had a rhinoplasty which only dealt with the bridge of my nose. I'm not happy with my nostrils and nose tip from my front view. I went to... READ MORE
Will the bump I see on my right (left in the pic) likely go away and become more symmetrical? (Photo)
I had a rhinoplasty/septoplastly revision surgery to fix a deviated septum & tip work. I had a hanging columella & bulbous tip. My surgeon used rib... READ MORE
Left side of nasal tip collapsed after injury. How can I tell if I'm symmetrical or if my nasal tip is twisted?
I was hit after a rhinoplasty. It shifted my whole nasal tip to the left. I think it shifted my natural nasal cartilages, too. In revision 3 mths ago,... READ MORE
My face is noticeably more unsymmetrical than most. Why do all PS want to make my nose symmetrical? It only makes it look off.
I have had three surgeries total. All I wanted in past two surgeries is to get my nose back to normal. Is it possible to use nasal bones and nasal... READ MORE


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Friends of the Animals Foundation
Rating: 4.98 stars 42 42 reviews 761
P O Box 16308 Seattle WA 98116 USA
Our mission is to foster greater compassion for animals by example and through education. Our primary goals are: 1) To reduce the number of animals abandoned, homeless, or killed until they all have a loving forever home. 2) To educate the community by providing information concerning • The right of animals to a life free of abuse or neglect • The resources that are available to those with a limited income • Volunteer opportunities to rescue, care for, and foster pets • The sad realities of failing to spay/neuter pets, and the plight of shelters • The steps to take BEFORE bringing a pet into your life
Since FAF began in 1997, we have placed over 4,000 cats and kittens into safe and loving homes. 2014: We adopted out 98 cats in 2014, down from 2013, but adult cat numbers were up. Over 25% of our adoptions were adult cats. We ended the year by adopting out two very special ones, Midge and John. There were fewer kittens in 2013 and they came later. Hopefully the focus on spaying and neutering is finally paying off. 2012: FAF was able to help at two adjoining addresses in the Highland Park area of West Seattle this spring. A total of five feral female cats, all nursing were TNR'd. One male cat was also altered. 11 kittens were trapped and put into foster care. The kittens were all able to find new homes after they were spayed/neutered. FAF and FCAT trapped 12 feral and one friendly cat living on the property of a home in Skyway. All were spayed/neutered and returned. FAF delivers 50 lbs of cat food monthly so the family is able to feed the cats healthy food, not rice as they had been eating. FCAT provided a huge Dogloo for shelter. We received a call about hungry kittens at a property in Burien. We were able to TNR four adult cats on the property. Seven very sick kittens were put into foster care first with FCAT and then an FAF foster home. All seven are now healthy, altered, and looking for new homes. FAF and FCAT were able to provide shelter to the remaining four cats. The elderly, disabled caretaker was very thankful. 2011: Our goal for 2011 was 150 adoptions. We came just shy of that goal with 123 adoptions. We were also busy with TNR—about 120 ferals TNR'd. 2010: In 2010 we had a total of 125 adoptions! Visit our website to read more of our accomplishments throughout the years.
Target demographics:
place cats and kittens into safe and loving homes and work with caretakers to trap/neuter/return cats and place the feral kittens into foster care for adoption once tamed.
Geographic areas served:
West Seattle and surrounding areas
TNR, Foster Care, Adoption
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Reviews for Friends of the Animals Foundation
1 person found this review helpful
I love what this organization does and takes the welfare of the cats and their kittens into consideration. I am a foster volunteer and also adopted two of my fosters. I am very grateful to be a part of this group and the bigger picture in life.
2 people found this review helpful
I was a foster parent for FAF and they made it a very easy and wonderful experience. I did adopt the babies and continue to support the organization how I can. All the work that is put into rescuing cats and managing feral communities is huge and helps the community. Keep up the work!!
1 person found this review helpful
I adopted a feral kitten from FAF two and half years ago, and my life has never been the same. The volunteers at FAF take such excellent care of their fosters and put so much love into socializing them that Ezio came to us friendly and fearless, and integrated flawlessly into our home. He's been an amazing little brother to our older cat, and helped her to be less shy and neurotic around other creatures, and has been the absolute sweetest cat I've ever had--he's all cuddles all the time, with everyone, and rarely leaves my side when I am home. It's pretty gratifying to be greeted at the door with enthusiastic purrs by a gigantic fluffy cat who wants nothing more than to curl up in your lap for a couple hours. I'm so grateful for the work the FAF volunteers put into his early care, from rescuing him and his family from the house under which they were sleeping up through his fostering and socialization--without them, he could've been just another sad story of a trapped cat euthanized in a shelter. He's brought so much love and joy into our lives, and I can't thank FAF enough for making it possible.
1 person found this review helpful
i adopted my cat Yoda from FAF and then became a foster Mom volunteer, This organization is truly devoted to helping vulnerable kittens and cats be well and find forever homes.
I am proud to be a volunteer!
Friends of the Animals does some of the most needed and appreciated work there is (by critters and humans alike)!
All praise and good tidings to the rescuers of the world.
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2 people found this review helpful
I adopted my cat, Piper, just over 4 years ago. FAF had rescued her, her siblings, and the mother-cat, from a rooftop in Burien. I will always be grateful to FAF for performing this rescue, thereby ensuring a long and happy life for Piper, her siblings, and her mother. Thank you for all that you do, FAF. The world is a better place with you all in it!
This organization is wonderful. They nurture and homes for our most vulnerable critters. I can't say enough good things about the work that they do!
1 person found this review helpful
They helped to take care of and place a momma cat that I had rescued. By the time I found them I had already found homes for all of the kittens. They still were able to meet with me to take the momma and get her fixed and everything else she needed. She was placed in a foster home until she went to the store and was found a forever home. I fully support their services and have recommended them to others.
2 people found this review helpful
I adopted my kitty Harvey, now known as Gozer almost two years ago. He had been a feral kitty and the nice people at FAF just knew he would love to have a home. Gozer's foster Mom teared up just a little bit at the adoption. I knew right then and there that FAF was a special group. All the kitties were lucky to have these wonderful volunteers in their lives doing their best to find them forever homes. Gozer is my best buddy, favorite cuddle bug, and such a good little boy. I am so lucky that we found each other. Thanks FAF!
1 person found this review helpful
I fostered for them for years and they worked so hard to rescue as many cats as possible. I was constantly amazed to their dedication to these animals. If I could I still would be fostering for them. My own cat Hermoine comes from fostering. I love her to death, one of the best cats I have ever met. All thanks to these guys! Please support them.
2 people found this review helpful
Since moving in to my old neighborhood, I started feeding a mama cat that was abandoned by a previous tenant at my apt. She was semi feral by the time I moved in. For years I fed her and every litter she had. If it hadn't been for MaryAnne from FAF, she would've continued having babies at an uncontrolled rate. MaryAnne got the mama & her adult babies fixed. And she rescued the new litter and found homes for them!!!
FAF also helped me with providing kibble/ canned food for the adult strays in the neighborhood. My interactions with them whether via social media or in person have always been great! I hope that they can continue all the great work they do for the neighborhood kitties!
3 people found this review helpful
FAF has a great group of volunteers. MaryAnne set up the TNR for the strays in my neighborhood, then came back to check on them. They set up "feeding stations" to make sure the cats are taken care of. They even drop off food to those who help feed the stray cats.


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Because I know the person so well (and not just because I took the picture), I can fill the before and the after of this instant with countless stories. Others can only wonder.
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I am a software engineer in London, UK. I update this blog sometimes. -- Eddy Young
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Publications (14)
Article: Combined inhibition of Chk1 and WEE1: In vitro synergistic effect translates to tumor growth inhibition in vivo[Show abstract] [Hide abstract] ABSTRACT: Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role of Chk1 in unperturbed cell proliferation and survival, implying that Chk1 inhibitors could also be effective as single agents in tumors with a specific genetic background. To identify genes in synthetic lethality with Chk1, we did a high-throughput screening using a siRNA library directed against 719 human protein kinases in the human ovarian cancer cell line OVCAR-5, resistant to Chk1 inhibitors. Wee1 tyrosine kinase was the most significant gene in synthetic lethality with Chk1. Treatment with non-toxic concentrations of a Chk1 inhibitor (PF-00477736) and a Wee1 inhibitor (MK-1775) confirmed the marked synergistic effect in various human cancer cell lines (breast, ovarian, colon, prostate), independently of the p53 status. Detailed molecular analysis showed that the combination caused cancer cells to undergo premature mitosis before the end of DNA replication, with damaged DNA leading to cell death partly by apoptosis. In vivo treatment of mice bearing OVCAR-5 xenografts with the combination of Chk1 and Wee1 inhibitors led to greater tumor growth inhibition than with the inhibitors used as single agents with no toxicity. These data provide a strong rationale for the clinical investigation of the combination of a Chk1 and a Wee1 inhibitor.
Article: Abstract 4699: A siRNA high-throughput screening identified Wee1 as determinant of Chk1 inhibitor sensitivity
Article: Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls[Show abstract] [Hide abstract] ABSTRACT: Recent studies showed that food-contaminant non-dioxin-like polychlorinated biphenyls (NDL-PCBs) congeners (PCB52, PCB138, PCB180) have neurotoxic potential, but the cellular and molecular mechanisms underlying neuronal damage are not entirely known. The aim of this study was to assess whether in-vitro exposure to NDL-PCBs may alter the proteome profile of primary cerebellar neurons in order to expand our knowledge on NDL-PCBs neurotoxicity. Comparison of proteome from unexposed and exposed rat cerebellar neurons was performed using state-of-the-art label-free semi-quantitative mass-spectrometry method. We observed significant changes in the abundance of several proteins, that fall into two main classes: (i) novel targets for both PCB138 and 180, mediating the dysregulation of CREB pathways and ubiquitin-proteasome system; (ii) different congeners-specific targets (alpha-actinin-1 for PCB138; microtubule-associated-protein-2 for PCB180) that might lead to similar deleterious consequences on neurons cytoskeleton organization. Interference of the PCB congeners with synaptic formation was supported by the increased expression of pre- and post-synaptic proteins quantified by western blot and immunocytochemistry. Expression alteration of synaptic markers was confirmed in the cerebellum of rats developmentally exposed to these congeners, suggesting an adaptive response to neurodevelopmental toxicity on brain structures. As such, our work is expected to lead to new insights into the mechanisms of NDL-PCBs neurotoxicity.
- [Show abstract] [Hide abstract] ABSTRACT: The phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway is a major target for cancer therapy. As a strategy to induce the maximal inhibition of this pathway in cancer cells, we combined allosteric mTOR inhibitors (rapamycin and RAD001) with a dual PI3K/mTOR kinase inhibitor (PI-103). Both in vitro and in vivo, the combination exhibited more activity than single agents in human ovarian and prostate cancer cells that harbor alterations in the pathway. At the molecular level, combined inhibition of mTOR prevented the rebound activation of Akt that is seen after treatment with rapamycin and its analogues and caused more sustained inhibition of Akt phosphorylation. Furthermore, the combination strongly inhibited the expression of PI3K/Akt/mTOR downstream proteins. In particular, it showed greater activity than the single agents in inhibiting the phosphorylation of 4EBP1, both in vitro and in vivo, resulting in selective inhibition of CAP-dependent translation. A proteomic approach was used to confirm the identification of c-Myc as the key regulator for the reduction in downstream proteins affected by the combined inhibition of mTOR. In conclusion, the combination of a catalytic and an allosteric inhibitor of mTOR shows greater activity, without a concomitant increase in toxicity, than either drug alone, and this may have therapeutic implications for inhibiting this pathway in the clinical setting.
- [Show abstract] [Hide abstract] ABSTRACT: Phisiological activation of PI3K pathway is necessary for cells to regulate many different physiological processes such as transcription, protein synthesis, metabolic responses and membrane trafficking. Abnormal activation of the PI3K pathway leads to an increased activity resulting in tumor onset, maintenance, progression and invasion. Both genetic and epigenetic alterations could affect the normal pathway's activation. Ovarian cancer is the leading cause of death from gynaecological malignancies in the western world. PI3K pathway has been recorded as one of the most deregulated signalling pathway in many tumors, including ovarian ones. So it could be considered an attractive target to be investigated with the various classes of chemical compounds already present or in development. In this rewiew we'll try to discuss the published data of the inhibitors targeting members of the PI3K/ akt/ mTOR pathway in the ovarian cancer setting from a preclinical and clinical point of view, with particular emphasis on drugs combination and strategies of administration. Relevant issues and limitations to the use of particular compounds will be also addressed.
Article: Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3 ',4 ',5 '-Trimethoxyflavonol, a Quercetin Analogue[Show abstract] [Hide abstract] ABSTRACT: Some naturally occurring flavonols, exemplified by quercetin, seem to possess experimental cancer chemopreventive efficacy. Modulation of p53 is a mechanism thought to contribute to their activity. The hypothesis was tested that a synthetic flavonol, 3',4',5'-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, Apc(Min) mice and human-derived HCT116 adenocarcinoma-bearing nude mice. Mice received TMFol with their diet (0.2%) from weaning to week 16 in the case of Apc(Min) or from either day 7 before ("TMFol early") or day 7 after ("TMFol late") tumor inoculation in HCT116 mice. The ability of TMFol to affect tumor proliferation or apoptosis, as reflected by staining for Ki-67 or cleaved caspase-3, respectively, was studied in HCT116 tumors. TMFol tumor levels were measured by high-performance liquid chromatography. Consumption of TMFol reduced small intestinal adenoma burden in Apc(Min) mice by 47%, compared with control mice (P < 0.002). The TMFol early regimen approximately halved HCT116 tumor size (P < 0.05), decreased tumor proliferation, and increased apoptosis, whereas the TMFol late regimen had no significant effect when compared with controls. In tumor tissues from mice, in which TMFol reduced tumor development, p53 expression was increased 3-fold in Apc(Min) and 1.5-fold in HCT116 tumor-bearing mice (P = 0.02). TMFol increased p53 also in cells derived from these tumors. TMFol was detected in HCT116 tumors, but levels did not correlate with tumor burden. TMFol was not mutagenic in the Ames test. The results suggest that chemical modification of the flavonol structure may generate safe and efficacious cancer chemopreventive agents.
Article: A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate[Show abstract] [Hide abstract] ABSTRACT: Owing to its role in cancer, the phosphoinositide 3-kinase (PI3K)/Akt pathway is an attractive target for therapeutic intervention. We previously reported that the inhibition of Akt by inositol 1,3,4,5,6-pentakisphosphate (InsP(5)) results in anti-tumour properties. To further develop this compound we modified its structure to obtain more potent inhibitors of the PI3K/Akt pathway. Cell proliferation/survival was determined by cell counting, sulphorhodamine or acridine orange/ethidium bromide assay; Akt activation was determined by western blot analysis. In vivo effect of compounds was tested on PC3 xenografts, whereas in vitro activity on kinases was determined by SelectScreen Kinase Profiling Service. The derivative 2-O-benzyl-myo-inositol 1,3,4,5,6-pentakisphosphate (2-O-Bn-InsP(5)) is active towards cancer types resistant to InsP(5) in vitro and in vivo. 2-O-Bn-InsP(5) possesses higher pro-apoptotic activity than InsP(5) in sensitive cells and enhances the effect of anti-cancer compounds. 2-O-Bn-InsP(5) specifically inhibits 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vitro (IC(50) in the low nanomolar range) and the PDK1-dependent phosphorylation of Akt in cell lines and excised tumours. It is interesting to note that 2-O-Bn-InsP(5) also inhibits the mammalian target of rapamycin (mTOR) in vitro. InsP(5) and 2-O-Bn-InsP(5) may represent lead compounds to develop novel inhibitors of the PI3K/Akt pathway (including potential dual PDK1/mTOR inhibitors) and novel potential anti-cancer drugs.
Dataset: Supplementary Table 3
Dataset: Supplementary Table 2
Dataset: Supplementary Table 1
- [Show abstract] [Hide abstract] ABSTRACT: Cell motility and invasion play an essential role in the development of metastasis. Evidence suggests that the enzyme phospholipase Cgamma1 (PLCgamma1) may be involved in tumor progression and possibly development of metastasis. In this study, we show that down-regulation of PLCgamma1 expression severely impairs activation of the small GTP-binding protein Rac and cell invasion in breast cancer cell lines and U87 in vitro. Experimental metastasis assays in nude mice show that inducible knockdown of PLCgamma1 strongly inhibits development of MDA-MB-231-derived lung metastasis and reverts metastasis formation. In addition, analysis of 60 breast cancer patients' tissues revealed an increase of PLCgamma1 expression in metastasis compared with the primary tumor in 50% of tissues analyzed. These data show a critical role of PLCgamma1 in the metastatic potential of cancer cells, and they further indicate that PLCgamma1 inhibition has a therapeutic potential in the treatment of metastasis dissemination.
- [Show abstract] [Hide abstract] ABSTRACT: Regulation of the p73 gene is complex due to the presence of two promoters and the very complex mRNA maturation in both the N-terminal and C-terminal parts of the protein. We have found an additional regulation mechanism for the p73-alpha form that occurs through proteolytic cleavage connected to the activity of the serine protease HtrA2. Following apoptotic stimuli, HtrA2 accumulates in the nucleus and cleaves p73alpha in the C-terminal portion, enabling the protein to increase its transactivation activity on the apoptotic gene bax but not on the cell-cycle regulator gene p21. In the presence of HtrA2, p73 is more prone to cause caspase activation and nuclei fragmentation: p73 needs HtrA2 to activate and enhance its apoptotic functions. This new relation between p73 and HtrA2 may help to understand the different behavior of the p73 protein in cell physiology and in the responses of cancer cells to chemotherapy.
- [Show abstract] [Hide abstract] ABSTRACT: Cell motility and invasion play an essential role in the development of metastasis. Evidence suggests that the enzyme phospholipase C;1 (PLC;1) may be involved in tumor progression and possibly development of metastasis. In this study, we show that down-regulation of PLC;1 expression severely impairs activation of the small GTP-binding protein Rac and cell invasion in breast cancer cell lines and U87 in vitro. Experimental metastasis assays in nude mice show that inducible knockdown of PLC;1 strongly inhibits deve-lopment of MDA-MB-231–derived lung metastasis and reverts metastasis formation. In addition, analysis of 60 breast cancer patients' tissues revealed an increase of PLC;1 expression in metastasis compared with the primary tumor in 50% of tissues analyzed. These data show a critical role of PLC;1 in the metastatic potential of cancer cells, and they further indicate that PLC;1 inhibition has a therapeutic potential in the treatment of metastasis dissemination.
Article: Cancer-derived p53 mutants suppress p53-target gene expression - Potential mechanism for gain of function of mutant p53[Show abstract] [Hide abstract] ABSTRACT: Tumour-derived p53 mutants are thought to have acquired 'gain-of-function' properties that contribute to oncogenicity. We have tested the hypothesis that p53 mutants suppress p53-target gene expression, leading to enhanced cellular growth. Silencing of mutant p53 expression in several human cell lines was found to lead to the upregulation of wild-type p53-target genes such as p21, gadd45, PERP and PTEN. The expression of these genes was also suppressed in H1299-based isogenic cell lines expressing various hot-spot p53 mutants, and silencing of mutant p53, but not TAp73, abrogated the suppression. Consistently, these hot-spot p53 mutants were able to suppress a variety of p53-target gene promoters. Analysis using the proto-type p21 promoter construct indicated that the p53-binding sites are dispensable for mutant p53-mediated suppression. However, treatment with the histone deacetylase inhibitor trichostatin-A resulted in relief of mutant p53-mediated suppression, suggesting that mutant p53 may induce hypo-acetylation of target gene promoters leading to the suppressive effects. Finally, we show that stable down-regulation of mutant p53 expression resulted in reduced cellular colony growth in human cancer cells, which was found to be due to the induction of apoptosis. Together, the results demonstrate another mechanism through which p53 mutants could promote cellular growth.


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By Rod Anderson , CP Cartoonist
October 10, 2012|9:10 am
The truth is, there's a certain type of personality that doesn't want accountability, but affirmation . . . When the pastor tells him the opposite of what he wants to hear, he leaves and goes to find a pastor or counselor who will. And this goes on and on.


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Christian Isaiah Barnes Pleads Not Guilty to Disneyland Dry-Ice Explosions: Update
See the update at the end of this post with Christian Barnes' not guilty plea and bail being halved.
ORIGINAL POST, MAY 30, 11:24 A.M.: The good news for Christian Isaiah Barnes, the Disneyland employee accused of setting off a dry-ice "bomb" in Toontown Tuesday, is his bail is expected to be cut in half.
The bad news is, even if the Long Beach 22-year-old can post a $500,000 bond, he's looking at up to six more years behind bars with a conviction.
As the Mexican-in-chief reported Wednesday, Barnes was arrested on suspicion of planting the explosive device and initially held in lieu of $1 million bail.
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Christian Barnes, Disneyland Cast Member, Arrested for Toontown Explosion, Held on $1 Million Bail
An Orange County District Attorney's office (OCDA) statement on Barnes expected 1 p.m. arraignment in Santa Ana today reveals he has been charged with a felony count of possession of a destructive device in a public place and that the judge is expected to set bail at $500,000.
Barnes works at outdoor vending carts in the Anaheim theme park, where he is accused of having had two water bottles containing dry ice with him on Tuesday.
When a female employee went to relieve Barnes sometime after 4 p.m., he opened a cart door and one bottle exploded, alleges the OCDA, which characterizes these homemade devices as dangerous.
Barnes is further accused of walking with the second bottle to the cast member break area but tossing it inside a Toontown trash can. Someone on garbage detail removed the trash bag holding the bottle and set it down briefly. That's when the second one exploded.
Toontown was evacuated, the Orange County Sheriff's Department Bomb Squad joined Anaheim Police at the scene, and no one was reported injured (save for some ringing in the ears) nor was there any damage, not even to the trash can.
Barnes was arrested shortly after police said they'd be examining Disney surveillance video from the area. His father has been all over the media saying he's a good boy who made a mistake, that this was a prank that police are overreacting to and that getting fired would be a reasonable punishment.
UPDATE, MAY 30, 3:18 P.M.: Christian Barnes pleaded not guilty at his arraignment today.
As expected, the judge halved his bail to $500,000. Barnes is due back in court June 7 for a pre-trial hearing.
Email: firstname.lastname@example.com. Twitter: @MatthewTCoker. Follow OC Weekly on Twitter @ocweekly or on Facebook!
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Cornish Game Hens
|Cornish hen
|2 Small
|Spaghetti squash
|Kosher salt
|1 Teaspoon, divided (For squash seasoning)
|Lemon pepper
|1⁄2 Teaspoon, divided (For squash seasoning)
|Garlic salt
|1⁄2 Teaspoon, divided (For squash seasoning)
|Soy sauce
|2 Tablespoon
|Red bell pepper
|1⁄2 Cup (8 tbs), canned
|Green beans
|1⁄2 Cup (8 tbs)
|1⁄2 Cup (8 tbs)
|1 Tablespoon
|Sea salt
|1⁄2 Teaspoon (For hens seasoning)
|1 Teaspoon
|Olive oil
|4 Tablespoon
1. Microwave spaghetti squash for few minutes. It's easy to cut when warm.
2. Deseed spaghetti squash and wash with running water.
3. Sprinkle kosher salt, lemon pepper and garlic salt over squash.
4. Wrap squash in cellophane wrap. Microwave on high for 10 minutes.
5. Take squash out from microwave and extract the flesh.
6. Add lemon pepper, garlic salt and soya sauce and blend well.
7. Chop red bell pepper and incorporate to the squash mixture.
8. Chop green beans and mushrooms.
9. Boil water, add in butter and put green beans.
10. After a few minutes add mushroom to the beans. Cook for a few minutes.
11. Preheat the oven to 350 degrees.
12. Take Cornish hens, cut it from the backbones.
13. Press chickens with hands.
14. Season chicken with sea salt, garlic sauce lemon pepper, and thyme.
15. Turn back the chicken and sprinkle seasoning.
16. Heat olive oil in a pan, add in seasoned chicken. Cook for 15 minutes.
17. Roast chicken in oven for 30 minutes.
18. In a plate serve hens with mashed squash, green beans and mushrooms. Serve hot.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 1397 Calories from Fat 710
% Daily Value*
Total Fat 80 g123.4%
Saturated Fat 19.4 g97.2%
Trans Fat 0 g
Cholesterol 257.5 mg85.8%
Sodium 3058.5 mg127.4%
Total Carbohydrates 132 g44.1%
Dietary Fiber 2.5 g9.8%
Sugars 2.7 g
Protein 55 g110.7%
Vitamin A 52.8% Vitamin C 152.3%
Calcium 46.2% Iron 48.1%
*Based on a 2000 Calorie diet


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- Standard sized deck with 52 cards and two jokers
- Comes in a gift box of exquisite mahogany
- 24K gold-plating has a .999 purity and comes with a certificate of authenticity
- Card back features a US $100 bill
- Makes a great upscale gift for any poker player or card enthusiast
Great Buy Online Store
Business in trade
ConditionsLimit: 99 for you and 99 gifts for others
Pay $2.95 extra per unit for delivery. Christmas delivery not guaranteed. Enter address when purchasing. Excludes PO Box & rural addresses. No refunds, no cash back, not to be used with any other offers.
See the rules that apply to all deals Delivery Timeframe: 21 days
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Voucher Guarantee
Getting more bang for your buck
Good news:
GrabOne's Voucher Guarantee means missing out on claiming your deal in time no longer means losing out altogether!
How does it work?
- A voucher is valid up to and including the expiry date stated.
- If you don't use your voucher before that date for whatever reason, it can still be used towards that service with that business for an additional 30 days.
For example, if you buy a bungy jump deal but don't use it before the expiry date, you can still use the amount you paid for the voucher towards a bungy jump, for another 30 days.
A few things to note:
- The GrabOne Voucher Guarantee does not apply to product deals, travel and accommodation-related deals, or time-dependent event deals.
- It's always best to use your voucher before the expiry date, so you get the most value for your money. And if you're a bit forgetful, we now automatically remind you if your vouchers are about to expire.
- During the extended Voucher Guarantee period, your voucher can only be put towards the service stated on the voucher.
- If the offer is seasonal, like a seasonal menu or chimney sweep service, the Voucher Guarantee can be put towards a similar offer at the merchant's discretion.
- The conditions on your voucher still apply during the Voucher Guarantee period.