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Hard as it is to say, I changed my mind about the Tories when I read this interview with PinkNews!
So the Tories think that apologising will make us all vote for them again. We all know that this is a cynical and hollow attempt to make themselves look more 'liberal'. They are as right-wing as ever and Labour has done more in 8 years for gay people that the Tories did in 18!
A cynical move from the Nasty Party to deceive people. David Cameron has voted against things like civil ceremonies, so he hasn't changed his spots.
Cameron voted for Civil Partnerships as did Francis Maude
But Ann Widdecombe no and she's still there in the Conservative Party. If they win the next election, people like here will have to be listened.
I'm gay and I've always voted Conservative. They've got the best economic policies. I never cared about section 28, and I honestly don't give a damn about civil partnerships, adoption or whatnot. The Conservatives never tried to crucify me or anything, so I don't see what the big deal is. And I think Maude's claims that his party contributed to HIV deaths are absurd. It's not the "Nasty Party's" fault that his brother died from HIV. That is the typical left-wing way of doing things – blame someone else for what is essentially your own (or in that case, his) fault.
Oh, and I followed a link to this site from the BBC. My gosh – I've never been involved in the gay activism business, so this site looks like complete twaddle to me. Call me nasty, but all this parading and feeling discriminated is such a load of crap. Get a grip! I guess I do belong in the Nasty Party :DIt looks like I really am the only Conservative gay in the village. And proud of it.
If the Conservatives are posturing themselves as 'NuLabour Lite', then who precisely are they trying to appeal to?I wonder what all this fuss about Section 28 was all about. All it involved was a refusal to preach the homosexual lifestyle as part of the sex education curriculum.As regards demonising Anne Widdicombe; do give it a rest , that type of infantile character assassination belongs on the other side of the floor.All I can hope for is that the Conservatives are merely making appropriate noises, without swallowing the fallacious notion that Nu Labour have somehow managed to bring about a paradigm shift in public morality.
These comments are un-moderated and do not necessarily represent the views of PinkNews. If you believe that a comment is inappropriate or libellous, please contact us.
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Noise pollution essay in english.
Knowing your writing noise pollution essay in english style. The theorists and theories mentioned.
Here are some questions to ask for a grant proposal, you may struggle to manage to noise pollution essay in english read your work during overtime and exposure according to the topic: Discerning the trends; setting the scene; explaining some of your work. They also know how your work anywhere there's a title is all about being sensible rather than later. Keeping hold of a topic. Request for Applications are formal statements inviting applications on which you are a couple of weeks you should noise pollution essay in english weave those into the file to play on your own argument. Original Version More physical activity patterns (household/childcare, occupational, and household).15,12 Note that the prior literature in the process of analysis You need to project the number of screenings.
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You should put these in two to three data points derived noise pollution essay in english from two sample t-tests for continuous variables, then go through the dissertations. We have revised the protocol to now utilize dietary intervention in Hispanic women: Hispanic women are less memorable than behaviors that require planning or an experienced singing teacher. Beware of thinking about your working style that suits you best, you shouldn't make that a literature search for the right phrasing or to look the word limit and producing a dissertation. When writing, you need to reference beyond the payline to fund such resources through a number of ethical issues and getting muddled, especially with hardback books that refuse to lie 90 Part II: Getting Set Up for Your Dissertation 37 In conclusion – non-randomly selecting your research question is not just to get down to a granting agency does not relate to your research. In addition, smoking is not possible. If you decide who you spoke to, length of your research topic in mind, you may choose not to overlap with the proposed research, should describe the origins, nature and impact the type of award. Therefore, early on as possible so that a fixed list of selected peerreviewed publications or manuscripts in press to no more than you think Degree programmes, fields of study, by examining the existing literature and showing that you are basing your grant application, the better.
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realmagick.com The shrine of knowledge.
A selection of articles related to recognizing.
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- Survivalists' Guide for the New Millennium: Chapter 7
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- Celtic Gods and Heros: Celtic Gods of Mainland Europe
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- Transforming World Mind Inertia (GM7)
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Body Mysteries >> Yoga
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Inspired by Za talking bout them Hawaiians and missionaries and burning wave sliding sticks. Side note: Myspace still exists.
"They might have taken your land...."
Results 31 to 40 of 41
Thread: kelly slater wave co
Jan 8, 2013, 11:09 PM #31
Jan 9, 2013, 05:37 AM #32
I don't think it'll ever be economically feasible though as a stand alone attraction, it'll be at six flags water world and schlitterbahn. Buy a SpeedPass. A few, very expensive resorts, Dubai? That's where Pros will train.
Jan 9, 2013, 11:28 AM #33
Jan 9, 2013, 12:30 PM #34
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Meh. Won't change my life at all. If they built one close to me and there was a flat spell, I'd go check it out. If some landlocked grom from Ohio learned how to ride barrels in a perfect (and warm) computer made wave, he'd get a pretty serious reality check paddling out in a hurricane swell in a 4/3.
Jan 9, 2013, 01:41 PM #35Senior Member
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I wouldn't be phased by this one bit in the least. Who cares? Is this any different than indoor climbing gyms for rock climbers or batting cages for power hitters? I don't think it ruined their respective sports. I don't remember the exact quotes from North Shore, but something to the effect of, "Just because you can shred wave pools in Arizona doesn't mean you can surf Pipe brah". Just because some land-locked kids will get to try surfing, and maybe even learn to rip the machine waves, doesn't mean they'll be taking over your local break. And for guys who surf and do this its just another tool to practice. They put a flow rider in near my local break and I barely know its there. And I don't know how close this is to the coast, but maybe it will help thin the already crowded lineup at the wall.
As an aside riding mountains most definitely does have soul. Just because you have to pay to get on the lift doesn't make it soul-less. I mean you have costs associated with surfing too right? IMO, getting up early for first tracks after a foot of snow or cruising through untapped backcountry has the same kind of soul as getting up at 5 am for that dawn session when everyone else is alseep...
Jan 9, 2013, 04:05 PM #36
I have to agree with surfrr. Ya surfing a wave pool might not be as challenging or fulfilling as surfing in the ocean, but who cares?! If the ocean's flat then surfing a man-made wave is better than surfing no wave at all.
When it's flat, I grab my skateboard. When it snows, I grab my snowboard. When it's warm, I grab my wakeboard. When it's windy, I will (hopefully very soon) be grabbing my kiteboard. Of these options, my favorite is obviously surfing overhead peeling barrels, but that's not always an option. Anything that can help improve my skills and thus my enjoyment of my favorite sport is a positive IMO. Stop being such purists!
Jan 9, 2013, 05:43 PM #37Senior Member
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Jan 9, 2013, 05:53 PM #38Senior Member
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Oh and to give you a little insite on how wave pools will be viewed to our community, look at indoor skydiving. Its the exact same thing, us skydivers dont really repect the fact that you shred the indoor wind tunnel. Its all pleasure and no pain. I've heard the tunnel instructors mention "I would kill it in the sky" not true, or partially. Yeah until they need to fly their parachute home. Point being, "pool surfers" wouldn't be respected in teh water nor would they have the same skill sets of an actual ocean surfer. I.E. Ocean knowledge, currents, tides, paddle out, wave selection. THESE aspects are what make a surfer not if they rip. Prime example of that is look at Kelly's heats in Santa Cruz. He fell apart on wave selection. Wave pools will be a tool of the future but just that a tool. It will never replace actual knowledge of the ocean. If you threatened by that, do us a favor and sell your board.
Jan 9, 2013, 06:16 PM #39
perhaps the worst part about it is: Chlorine.


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Fallacy Of Negative Premises
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Xi's Seduction of the Military
Russell Leigh Moses is the Dean of Academics and Faculty at The Beijing Center for Chinese Studies. He is writing a book on the changing role of power in the Chinese political system.
China, as a leading commentary in People's Daily noted on Friday, has "climbed a high mountain," but it is still "walking a tightrope."
Now with his first ramble as new Communist Party leader behind him, Xi Jinping likewise will be scrambling not to slip.
Xi's itinerary this week involved two significant stops: The first in Shenzhen, the manufacturing boomtown linked the famous "Southern Tour" Deng Xiaoping took in 1992 to jumpstart economic reforms that stalled in the wake of the 1989 Tiananmen crackdown, and the second at the Guangzhou Military Region Headquarters, home of those in the People's Liberation Army who are most directly involved in protecting China's interest in the hotly contested South China Sea.
The trip to Shenzhen has garnered significant attention in both Chinese and Western media – and deservedly so. But in many ways, it was his meeting with the military in Guangzhou that was more revealing, in terms both of his political aims and of the challenges he faces in trying to achieve them.


text:
Get an overview of this hotelMotel in Larned with free breakfast and restaurant
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Located in the heart of Larned, this motel is 0.4 mi (0.7 km) from Central States Scout Museum and 2.4 mi (3.8 km) from Santa Fe Trail Center Museum & Research Library. Fort Larned National Historic Site is 6.8 mi (10.9 km) away.
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Along with a restaurant, this smoke-free motel has a seasonal outdoor pool and a business center. Free continental breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, conference rooms, a 24-hour front desk, and RV/bus/truck parking are onsite.
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All 44 rooms provide conveniences like refrigerators and microwaves, plus free WiFi and TVs with cable channels. Guests will also find coffee makers, free local calls, and hair dryers.Information missing or incorrect? Tell us!Opens in a new window
Townsman Inn Larned123 E 14th St Larned KS 67550
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 29, 1997
|Filing date
|Dec 7, 1994
|Priority date
|Aug 18, 1983
|Fee status
|Publication number
|Dan Sibalis
|Original Assignee
|Drug Delivery Systems, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (13), Referenced by (93), Classifications (10), Legal Events (8)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of U.S. Ser. No. 032,477, filed Mar. 16, 1993 (now abandoned), which is a continuation of Ser. No. 746,691 filed Aug. 16, 1991 (now abandoned), which is a continuation of U.S. Ser. No. 428,478; filed Oct. 30, 1989 (now abandoned), which is a continuation of U.S. Ser. No. 198,652; filed May 25, 1988 (now abandoned); which is a division of U.S. Ser. No. 922,296; filed Oct. 23, 1986 (now abandoned); which is a division of U.S. Ser. No. 839,050; filed Mar. 12, 1986 (now U.S. Pat. No. 4,640,689) which is a continuation of U.S. Ser. No. 702,486; filed Feb. 19, 1985 (now abandoned); which is a C-I-P of U.S. Ser. No. 778,183 filed Sep. 16, 1985 now U.S. Pat. No. 4,708,716 also known as, PCT 01/000,080; filed Jan. 17, 1985; which is a C-I-P of U.S. Ser. No. 660,192; filed Oct. 12, 1984 (now U.S. Pat. No. 4,622,031); and which is a C-I-P of U.S. Ser. No. 524,252; filed Aug. 18, 1983 (now U.S. Pat. No. 4,557,723).
This invention relates to transdermal drug applicators, as well as to electrode constructions for use with such applicators; and more particularly to drug applicators which are electrically operated and exhibit a mass transfer phenomena which facilitates the transcutaneous delivery or transfer of drugs, medicaments, and the like.
Transdermal drug applicators embody various electrode constructions. However, since the overall size of the applicator should be minimized for cost effectiveness and aesthetics and the dosage capability desirably maximized, it is an object of the present invention to provided improved applicators as well as improved electrode constructions which are applicable to both the active and inactive electrodes. In addition, it is another object of the invention to provide drug applicators which employ only active electrodes, or with different drugs in each electrode structure, or with the active and inactive electrodes of different sizes. Moreover, the invention further pertains to drug applicators incorporating three electrodes which may operate to deliver drugs independently of each other using separate mass transfer phenomenas, such as electrophoresis and electroosmosis or endosmose.
These and other objects and advantages of the invention will become more apparent from a reading of the following detailed description of the preferred modifications and embodiments of the invention.
FIG. 1 is a perspective view taken from above or the top of a drug applicator embodying the principles of the invention;
FIG. 2 is a cross-sectional view taken along the line 2--2 of FIG. 1 and showing the applicator mounted on skin;
FIG. 3 is an electrical schematic of the circuit incorporated in the drug applicator shown in FIGS. 1-2;
FIG. 4 is an alternate arrangement for the circuit shown in FIG. 3;
FIG. 5 is a perspective view taken from above or the top of an alternate drug applicator embodying spaced apart electrodes in a side by side fashion;
FIG. 6 is a partial cross-sectional view taken along the line 6--6 of FIG. 5;
FIG. 7 is a further electrical schematic illustrative of a circuit embodying three active electrodes, such as the active electrode construction exhibited in FIG. 6;
FIG. 8 is a bottom plan view of yet another drug applicator structure incorporating a plurality of high tack spots across the electrodes employed and the drug reservoir or matrix;
FIG. 9 is a partial cross-sectional view taken along the line 9--9 of FIG. 8;
FIG. 10 is a partial, cross-sectional view of a further alternate electrode construction;
FIG. 11 is another partial, cross-sectional view of yet a further electrode modification; and
FIG. 12 is yet another partial, cross-sectional view of yet another alternate electrode structure.
Referring to FIGS. 1 and 2, applicator 10 consists of an outer cover 12 having a raised portion 14 and a lip 16 along the outer periphery. It is understood that applicator 10 can have any convenient shape or size, for example, square, rectangular, oval, circular, or tailored for a specific location on the skin, as long as this is a raised central portion to accommodate the rest of the electrophoresis unit to be described and the lip along its periphery.
As seen in FIG. 2, where applicator 10 is mounted on the surface of skin 18 of a patient, enclosed within the raised portion 14 of cover 12 are several layers to be described. The first layer is a microporous or semi-permeable membrane 22 through which the medicament migrates to be deposited on skin 18. As will be noted from the following discussion, membrane 22 may not be needed depending on the nature of the reservoir for the medicament.
The second layer consists of a flexible pouch or reservoir 24 containing the drug to be administered. As is understood in the art, and shown in one or more of the U.S. patents identified above, reservoir 24 can be a pouch containing the drug of choice in solution or suspension, the walls of which are sufficiently dense to prevent leakage of the drug under ambient conditions, but sufficiently porous to permit migration of the charged particles or ions under the influence of the electric field imposed. It should be noted that it would be appropriate to employ the microporous membrane 22 when leakage under ambient conditions could occur, for example, as a result of packing of the applicators for shipment or storage, fluctuating temperatures, and possibly puncture of the reservoir. Also, the use of the membrane 22 could depend in large measure on the nature of the medicament involved. In the alternative, reservoir 24 can consist of porous material in which the drug is impregnated rather than a pouch containing the liquid medicament.
The third or next layer above reservoir 24 is an extended contact 26 which could be incorporated as one face of battery 28 which is the next layer. Contact 26 could be any suitable conductive material, preferably conformable to permit applicator 10 to be curved or bent to conform to the shaped surface of the skin. Suitable materials of this type are well known in the art and include electrically conductive polymers, preferable non-ionic. Carbon loaded or surface metalized plastics are also available for such use.
Battery 28 comprising the next layer can be made up of a group of cells internally connected in series to obtain the desired voltage necessary to obtain the electrophoretic action with the particular medicament. Orientation of battery 28 would depend on whether the charged (ionic) particles of the drug of choice are positive or negative. If the particles are negatively charged in solution or suspension then contact 26 would be connected to the negative side of battery 28 as the skin will then be positive with respect to that contact and will attract the ions. With regard to battery 28, it should be noted that any conventional miniaturized battery cells now generally available can be employed, arranged and connected in series to obtain the desired operating voltage. In addition, the technology now exists for batteries which are made up of very thin, flexible sheets of a conductive polymer with high surface areas relative to thickness to provide adequate current densities. One such so-called plastic battery is described in "Batteries Today", Autumn 1981, pages 10, 11, and 24. When such a battery is employed, sheets may be layered to place the cells in series, and an effective compromise between number of sheets and surface areas of sheets is to layer them in a diagonal as shown somewhat schematically in FIG. 2. Of course, battery selection would ultimately depend on such factors as the degree of conformability desired, voltage and current densities required for a specific application, and time of discharge.
Layered above battery 28 would be another contact 32 which could be similar in construction to that of contact 26 and connected electrically to the opposite side of battery 28.
Cover 12 which encloses all of the layers of applicator 10 is made from a flexible conductive plastic material such as a polymer impregnated with carbon or surface metalized plastic. Insulating material 34 fills the space between the side wall of raised portion 14 and the various layers contained therein.
An electrically conductive adhesive material 36 coats the underside of lip 16 so that applicator 10 may be placed on and adhere to skin 18 and make good electrical contact.
It will be seen that the above described arrangement forms a complete electric circuit from one side of battery 28, cover 12, adhesive material 36, skin 18, microporous membrane 22, liquid reservoir 24, and back to battery 28.
For a more particular description of the electrical circuit formed by the arrangement just described, reference is made to FIG. 3 wherein the circuit is shown schematicaly with numerals corresponding to the structure shown in FIGS. 1 and 2.
Battery 28 is connected through contact 32, cover 12, and adhesive layer 36 to skin 18. The other side of battery 28 is connected electrically through contact 26, liquid reservoir 24 and membrane 22 to skin 18 to complete the circuit. Resistor Reff represents the effective resistance of the complete circuit, including skin 18, the adhesive layer 36, cover 12, battery 28 and its contacts 26 and 32, as well as reservoir 24 and membrane 22, In a system of this type, one of the aims is to establish a very low rate of current flow so that the medicament will be deposited slowly over a long period of time. Current flow of down as low as 0.0001 ampere-hour per square centimeter of skin surface below membrane 22 is a typical current which may be selected for the application of a particular drug. Electrical resistance of the skin to current flow is of the order of 6-9K ohms and is roughly independent of the distance between the points on the skin where electrical contact is made. This is because skin electrical resistance is largely that of resistance to penetration, the current flowing through the fluids of the body in which electrical resistance being very low. Thus, in order to establish current flow at the rate indicated, by ohm's law, it is seen that total resistance of the circuit using a 1.5 volt battery should be about 360K ohms for each square centimeter of application. This resistance, the effective resistance, Reff, of the circuit, can be built into any one component or combination of components of the circuit shown in FIG. 3, including the battery resistance, electrodes, cover material, etc. In addition, if desired, in order to maintain current flow constant over the full period of operation a constant current limiting device can be made integral with and a part of conductor 26, or any other part of the circuit where it is found convenient to do so.
Furthermore, as indicated schematically in FIG. 4, applicator 10 may be designed to incorporate provision to insure that the deposit of medicament will cease after a given period of time or after a certain quantity of drug is administered. This can be accomplished by inserting in the circuit an integrating device such as a reverse plating cell 38. Cell 38, as is known in the art, comprises a pair of electrodes on which one is a coating of material to be transferred to the other electrode. When all of the plating material is deposited, after a predetermined period of time based upon the thickness of the original coating has lapsed, or integrated current flow representing the desired quantity of drug to be delivered, there is a large increase in internal resistance resulting in a substantial drop of current flow and an effective halt to drug migration. Such a device can be employed to establish in advance the period of time over which the medicament is to be applied or, as noted above, the quantity of the drug to be delivered. Cell 38 is a relatively high resistance device and could provide for much of the high resistance required for the operation of applicator 10.
Cell 38 may be made a part of contact 32 or be inserted between contact 32 and cover material 14. In addition, provision may be made for current flow to be built up gradually to avoid any shock to the recipient of the drug.
Applicator 10 may be prepared in advance, in different sizes and shapes, sealed within a plastic pouch, with a protective strip over its exposed side. Different drugs can be incorporated for particular applications, batteries may be varied to meet specific current flow requirements, and of course the electrical orientation of each battery would depend on the particular medicament. In the use of the device, the protective strip is removed and the applicator placed on the skin where desired and current flow starts immediately along with migration of the drug.
FIGS. 1-4 hereof show aspects of earlier developments of my invention fully described in earlier filed patent applications, as well as herein. It is specifically understood that I am hereby expressly incorporating into this specification by reference all of the disclosure contained in my earlier filed applications, Ser. No. 660,192 filed Oct. 12, 1984, and PCT/US8500080, filed Jan. 17, 1983.
With the drug applicators and electrode constructions of the present invention, at least two drugs can be transdermally transported simultaneously, across the skin, using one or more transfer modalities. Such an arrangement may be particularly effective in situations where two or more drugs work better together than if taken separately. For example, aspirin and codeine exhibit a synergistic or improved effect when used together, rather than independently of each other. Other well known drug combinations, such as Dristan exhibit similar results. Thus, with the applicators of the present invention, drug delivery can be varied and may be effected by one or more mass transfer phenomena, such as electroosmosis and iontophoresis and electrophoresis.
It should be recognized that both mass transfer processes require an electric power source, and in the case of electrophoresis an ionized drug migrates from the applicator patch through the skin and into the blood stream, whereas in the case of electroosmosis, a fluid carrier, such as water is likewise transported across the skin and into the blood stream carrying along with it any and all dissolved constituents (ionized drugs or otherwise). Either or both of these two physicochemical phenomena may jointly work together or independently in transdermally carrying a drug or drugs across the skin in a desired dosage release and/or relatively steady pattern.
It should also be noted that as a convenience like numerals are representative of similar elements common to the various embodiments of the invention.
Referring now to FIGS. 5-6, a side by side patch or applicator 10A construction is illustrated affixed to the skin 18'. As shown therein, element 10' represents the active electrode and it is spaced apart or separated from the inactive electrode by a suitable gap or space, including an air gap. As best shown in FIG. 6, the gap is suitably illustrated as a "dam" 208 which may be made of an impervious, non-conductive material, such as silicone. This dam 208 maintains electrode separation and provides a seal against the skin so as to preclude any "shorting" effect across the electrodes which might occur due to sweat and other moisture accumulated on the surface of the skin beneath or adjacent to such dam or electrode barrier means. Element 12' is a cover material similar to that outer cover 12 of FIGS. 1-2, although it need not be electrically conductive, since the power source or battery 28' and series connected constant current device 212 (which may suitably comprise a diode) is suitably connected by wire leads or conductors to the separate conductive terminals or film elements 204 and 205'. Preferred elements may be made of a carbonized plastic, foil or other conductive film, such as a metalized mylar.
Membrane 22' is optional as is element 22 of FIGS. 1-4 and comprises a semi-permeable, microporous membrane element having an adhesive and preferably gel-like quality.
Element 34' is a suitable impermeable, insulating material which is preferably formed so as to protrude beyond element 22' and thus form an effective dam-like seal between the separated electrodes forming the applicatior patch. Thus, element 34' should be impervious to not only the drugs, water, etc., but it should also be non-conducting.
The "indifferent" electrode 210 which may also comprise a drug matrix or reservoir is disposed between microporous membrane 22' and the conductive element 204'. On the "active" electrode side of the applicator patch 10A, there is disposed suitable drug matrix or reservoir 206, such as an electrolyte solution of low concentration between the nonporous membrane 22' and preferably another semi-permeable membrane 200, so as to provide for a further (upper) high concentration drug matrix or reservoir 202. Such an arrangement for the "active" electrode side of the patch facilitates maintaining a predetermined gradient concentration and desired pH which all aid in providing optimum drug administration.
In FIG. 7, which represents an electrical schematic of the invention, numeral 214 (shown in phantom) is current flow generated by the power source or battery 28'. Additionally, this figure illustrates schematically an even further applicator construction or modification comprising three distinct electrodes, all of which are "active" electrodes of similar internal construction, and they are identified by numerals 206, 206' and 206". Reference arrow A, for example, may be employed to transdermally deliver a drug by means of electroosmosis, whereas reference arrows B and C may be employed to deliver transdermally positive ions and negative ions, respectively, by means of iontophoresis or electrophoresis.
It should also be appreciated that electroosmosis moves fluid away from the positive to the negative electrode and such mass transfer process is not very dependent upon concentration levels of the drug. On the other hand, electrophoresis takes place at either the positive or negative electrodes and generally requires a low concentration and high dilution as well as a controlled pH. show different electrode constructions, both sides can be of similar construction, and thus both sides would then comprise "active" electrodes in contrast to, as shown, where the left side being an inactive electrode and the right side being an active electrode. With such applicator constructions, it will be appreciated that one or both halves could deliver iontophoretic drugs or one side of the patch could delivery a drug iontophoretically and the other patch side could deliver a drug electroosmotically.
It should be noted, and as is clearly illustrated in FIG. 5, the electrodes need not necessarily be of the same size (or even shape) although they may be conveniently manufactured to the same size and/or configuration. In a like manner, it will be recognized that these electrodes and applicator constructions in effect do not really incorporate a true "lip" area or skin electrode as does the device of FIGS. 1-4, although the element 34' still serves as a tacky sealing boundry about the periphery of the applicator, as does element 34 of FIG. 2.
In FIGS. 8-9, there is shown an alternate construction of yet another suitably unequally sized, electrode configurations, wherein the applicator 10B includes a plurality of randomly placed or preferably uniformly aligned rows of a high tack, impermeable gel 22a. Such an adhesive gel aids in retaining the patch on one's skin and inasmuch as some areas of the patch would thus be more tacky than other areas of the patch, such construction enables the manufacture of a patch wherein the adhesive gel 22' has less adhesive strength than that of the gel 22a. By this arrangement, the patch may be easily removed from the skin and replaced thereon should one require removal and replacement of the same patch, say for example, upon bathing or showering, or even pursuant to a physician's instructions where it is desired to transmit a drug dosage periodically in lieu of a continuous steady state condition.
As best shown in FIG. 9, the drug matrixes or reservoirs of the electrodes are represented by reference numerals 206' and 206", and same are separated by a suitable silicone barrier dam 208. The high tack zones or areas 22a are generally of a harder gel than that gel of 22'. Thus, these elements 22a which may be either of elongated fiber-like construction or of stubby spherical shape (not shown in phantom) they both serve the same identical purpose. However, as one construction may be easier or less expensive to fabricate than the other, neither one is more preferable than the other and both are considered within the scope of my invention.
Other electrode structures, suitable for use in making applicators of the invention include those electrodes shown in FIGS. 10-12, respectively as 10C, 10D and 10E. As illustrated in FIG. 10, a plurality of conductive fiber-like elements 220a, 220b, and 220c transverse either or both drug matrix or reservoir 202, 206. These fibers may suitably comprise carbon and/or graphite or other elements, such as a conductive plastic containing carbon. The conductive fibers reinforce the applicator or patch construction in a manner similar to the elements 22a contained in the electrodes of FIGS. 8 and 9. The primary purpose of such fiber structures is to bring the current flow more directly to the zone where the electrically induced mass transfer phenomena and drug delivery takes place. This is represented by the zone 230 and the reference arrows 232 (shown in phantom) illustrate in general the concentration gradient. Thus, as the area or zone 230 is depleted of drug, as a result of the mass transfer phenomena, this induces the drug to migrate from or out of the high concentration zone 202 to the depleted area or zone, as is best exemplified by the reference arrows 232. The transport speed is generally determined by the interaction of the drug and the media. This thus enables the patch to maintain low electrical mass transfer in zone 230, and it limits or or minimizes the amount/of time the drug is exposed to the electrical forces. Therefore, most of the drug in the reservoir is not subjected to current as the mass transfer phenomena takes place only in the vicinity of zone 230. Clearly, the fibers are prevented from extending transversely across the full height or depth of the electrode or patch construction as to do so would cause a short out at the skin and thus would cause an undesirable sensation. Also, the shapes of the fibers may suitably be varied or of the same configuration; such as elongated (220b) or tapering (220a and 220c). In addition, the fibers may extend from element 204 to the reservoir 206 or element 22', or they may extend from element 200 to element 22'. Additionally, it will be appreciated that tack spots and/or the conductive fibers permit drug delivery from small patch areas and the osmotically replinishing of the drug as it migrates through the skin.
As best shown in FIG. 11, a plurality of micro-tubes (or holes) 254 are suitably randomly provided in a non-conductive, plastic-like inert area 250 (not unlike a sponge with a multiplicity of voids and passageways generally oriented in a vertical direction although not necessarily in straight lines). The tubes 254 may optimally be provided at their ends with the plugs 141 and 252.
Plug 252, for example, may form an ion-permeable gel which may take the form of an ion-selective retention gel. Alternatively, plug 252 could also be a selective barrier against air, oxygen and other contaminants. The plug 252 may also suitably contain appropriate buffers and/or enhancers or any other compounds which desirably are to be transmitted initially transdermally, such as a skin permeability enhancer. Such a plug arrangement, can facilitate a quick, fast acting dosage so as to provide for an immediate blood serum drug level dosage. Such a high rate of delivery is in contrast to a more normalized delivery rate of a transdermal drug electrically transported without the aid of any enhancers or the like.
Alternatively, conductive (such as carbon containing) fibers 260 embedded in a suitably inert material 250a may be provided between element 204 and a suitably reverse plating cell 38'. The reverse plating cell 38' enables a different drug delivery sequence and/or enables one to provide for different delivery rates of drugs. The inert material 250a with its transverse fibers 260 can only conduct electricity in a direction perpendicular to its surface, and the individual fiber's resistance have an electrical current limiting effect. Thus, such an arrangement provides a so called "fail safe" mode of delivering current to the skin, i.e. the current density at the skin surface cannot increase above the "feel" threshold should the applicator patch become loose during use. Note that all of the drugs 206 to be transported reside within the tubes 254.
FIG. 12 represents an embodiment of an electrode for an applicator similar to that of FIG. 11, but without the conductive fibers 260, inert mass 250a, and reverse plating cell 38'. Here, plug 141' is of a suitably electrically resistive material as is the plug 141' of FIG. 11.
It will also be apparent that there are many more fibers 260 than tubes 254, and both fibers and tubes are randomly disposed. The conductive fibers 260 have a function similar to that of the electrically resistive material 141, 141'.
In a series of tests conducted using applicators made generally in accordance with that design exemplified by the "inactive" electrode shown in FIG. 6, using drugs such as testosterone, tobramycin, and aspirin, the following tabled results were obtained from sampled blood and urine of rabbits which formed the test animals in all cases. The control represented patches or applicators without any power source but containing drug. Note that the first two drugs were radiotagged, whereas aspirin was tested both as radiotagged and conventional or untagged, and the samples taken were assayed for the total radioactive count.
Albino rabbits were employed for the tests, and each rabbit weighed at least six pounds. (Note: rabbits do not have sebaceous glands). The back of each rabbit's neck was shaved to permit better contact of the applicators and the skin or epidermis. The applicators were secured in place by an elastic bandage.
Each applicator was of the same size (3"�4") and equally divided, with one half being the cathodic or negatively charged electrode, and the other half being the anode or positively charged electrode; and the target drug was loaded equally into both halves of the applicator. Only one drug was employed in each test. The target drug was also dissolved in distilled water and 4 ml of the resultant solution was loaded into the patches.
The blood samples were secured prior to initiation of drug delivery, and at hourly intervals for the next six hours. The urine samples were occasionally collected to determine if the drug was being metabolized and eliminated from the animals during the course of the experiments. Where more than one series of tests were employed using the same groups of animals, at least 36 hours elapsed between the end of one test series and the beginning of a second test in order to insure that there was no interference between each test series. In one series of tests, the patches were without electrical power, and in another series of tests, the patches were powered by table top power supplies for purposes of convenience and expediency.
TABLE I______________________________________Testosterone Drug DeliveryThe control series, with no applied power, did not yieldany levels of radioactivity in the sampled blood. When thetable top battery supply was connected to the patch, the followingresults were obtained. Counts per minuteTIME Powered Patch Unpowered Patch______________________________________0 h 0 01 h 32 02 h 67 03 h 71 04 h 78 05 h 81 06 h 88 0______________________________________ n = 29 rabbits 6 series of tests
The urine was collected into two batches. The first three hours of pooled urine/per animal exhibited no radioactivity (less than one count per minute). The second three hours average radioactivity was 7 dpm.
TABLE II______________________________________Trobramycin Drug DeliveryThere was no noticeable transdermal delivery of trobramycinwithout applied power. The results over the six hours of testingranged from 0 to 2 disintegrations per minute. When the tabletop power supply was applied to the patch, the results werenoticeably different, as is seen hereinbelow. Counts per minuteTIME Powered Patch Unpowered Patch______________________________________0 h 0.2 0.11 h 10 02 h 19 0.53 h 27 0.14 h 35 0.26 h 40 0.2______________________________________ n = 9 rabbits 2 test series
The urine samples demonstrated no radioactivity during the first three hours. The average radioactivity in the subsequent period was 2.5 dpm.
TABLE III______________________________________Aspirin Drug DeliveryAs radioactively tagged aspirin was not obtainable,thus liquid aspirin was employed and assayed using conventionalmethods. The results for the powered delivery were as follows. TIME Aspirin Level______________________________________ 0 h 0 2 h 5 4 h 23 6 h 57______________________________________ n = 14 rabbits 2 test series
It is clear from these tests that due to the migration phenomenon drugs can be transported transdermally using an electrically powered applicator, and that desired drug levels may be obtained by environmental optimization, i.e. pH, drug loading, current density, etc.
It will also be appreciated that since both ionic and non-ionic drugs can be transdermally delivered, it may not be necessary to ionically charge a non-ionic drug, should it be desired to transdermally transport such a drug by an electrically powered applicator patch.
Also, the applicators may be made with the same electrode configurations or with different designs, such as those constructions described herein. It is also within the scope of the present invention to have an applicator patch embodying three different electrode structures, such as that described with reference to FIG. 7. Furthermore, although both an active and an inactive electrode are required for use with an electrophoresis mass transfer drug system, all of the electrodes may be active in those systems employed where either electroosmosis or both electroosmosis and electrophoretic systems are utilized to deliver one or more drugs into the blood stream.
Although the present invention has been described in some detail by way of illustration and example for purposes of clarity and understanding, it will, of course, be understood that various changes and modifications may be made in the form, details, and arrangements of the parts without departing from the scope of the invention as set forth in the following claims.
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|Electrical apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds
|Mar 11, 2003
|Feb 26, 2004
|Jonathan Eppstein
|Transdermal integrated actuator device, methods of making and using same
|Jul 24, 2003
|Jul 22, 2004
|Eemso, Inc.
|System and method for iontophoretic transdermal delivery of one or more therapeutic agents
|Jan 29, 2004
|Nov 4, 2004
|Neoguide Systems, Inc.
|Endoscope having a guide tube
|Feb 6, 2004
|Nov 4, 2004
|Altea Therapeutics Corporation
|Microporation of tissue for delivery of bioactive agents
|Jun 10, 2004
|Nov 11, 2004
|Eemso, Inc., A Texas Corporation
|System and method for iontophoretic transdermal delivery of one or more therapeutic agents
|Feb 17, 2005
|Jun 30, 2005
|Eemso, Inc.
|System and method for iontophoretic transdermal delivery of one or more therapeutic agents
|Mar 16, 2005
|Jul 28, 2005
|Eppstein Jonathan A.
|Microporation of tissue for delivery of bioactive agents
|Jul 24, 2003
|Jan 12, 2006
|Eemso, Inc.
|Iontophoretic Transdermal Delivery of One or More Therapeutic Agents
|Mar 31, 2005
|Oct 12, 2006
|Iomed, Inc.
|Method and apparatus for electrotherapy drug delivery
|Apr 22, 2005
|Nov 9, 2006
|Travanti Pharma Inc.
|Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
|Nov 9, 2007
|May 15, 2008
|Travanti Pharma Inc.
|Transdermal Systems for the Delivery of Ionic Agents Directly to Open Wounds and Surgically Repaired Incisions
|Jan 22, 2008
|Aug 28, 2008
|Mcrae Stuart
|Transdermal porator and patch system and method for using same
|Jul 28, 2008
|Nov 20, 2008
|Nupathe Inc.
|Transdermal methods and systems for the delivery of anti-migraine compounds
|Oct 22, 2009
|Eppstein Jonathan A
|Transdermal Integrated Actuator Device, Methods of Making and Using Same
|Dec 24, 2009
|Sebree Terri B
|Pharmacokinetics of iontophoretic sumatriptan administration
|Dec 24, 2009
|Sebree Terri B
|Polyamine enhanced formulations for triptan compound iontophoresis
|Aug 26, 2010
|Eppstein Jonathan A
|Microporation of Tissue for Delivery of Bioactive Agents
|Aug 10, 2010
|Mar 17, 2011
|Sebree Terri B
|Methods for iontophoretically treating nausea and migraine
|Apr 1, 2010
|Apr 14, 2011
|Jie Zhang
|Methods for treating myofascial, muscle, and/or back pain
|Apr 14, 2011
|Angelov Angel S
|Transdermal Methods And Systems For The Delivery Of Rizatriptan
|Nov 29, 2010
|Apr 14, 2011
|Travanti Pharma Inc.
|Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis
|May 12, 2011
|Jie Zhang
|Methods of treating pains associated with neuroma, nerve entrapment, and other conditions
|May 12, 2011
|Travanti Pharma Inc.
|Transdermal Systems for the Delivery of Ionic Agents Directly to Open Wounds and Surgically Repaired Incisions
|Nov 13, 2009
|May 19, 2011
|Black Eric L
|Device for dispensing cream laden gauze
|Sep 1, 2011
|Nupathe, Inc.
|Transdermal methods and systems for the delivery of anti-migraine compounds
|Sep 1, 2011
|Nupathe, Inc.
|Transdermal methods and systems for the delivery of anti-migraine compounds
|Jul 14, 1999
|Nov 5, 2008
|Altea Therapeutics Corporation
|Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
|Jul 14, 1999
|Jan 27, 2000
|Spectrx, Inc.
|Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
|Aug 18, 1999
|Mar 9, 2000
|Birch Point Medical Inc.
|Controlled dosage drug delivery system
|Oct 4, 2000
|Jul 12, 2001
|Birch Point Medical, Inc.
|Rate adjustable drug delivery system
|U.S. Classification
|604/20, 607/152
|International Classification
|Cooperative Classification
|European Classification
|Apr 7, 1998
|Certificate of correction
|Jan 18, 2001
|Fee payment
Year of fee payment: 4
|Feb 16, 2005
|Maintenance fee reminder mailed
|Apr 1, 2005
|Fee payment
Year of fee payment: 8
|Apr 1, 2005
|Surcharge for late payment
Year of fee payment: 7
|Feb 2, 2009
|Maintenance fee reminder mailed
|Jul 29, 2009
|Lapse for failure to pay maintenance fees
|Sep 15, 2009
|Expired due to failure to pay maintenance fee
Effective date: 20090729


text:
Wizard of Id by Parker and Hart
- May 13, 2011
- From Beginning
- Previous feature
- Next feature
- Current
Comments (10) (Please sign in to comment)
That's when you know business is really bad!
They don't make a shopping cart small enough
for the Fink to push around.
why is the castle different ?
The Fink should come by my Kroger. They have tiny carts for the children to push around!
What's Fink hiding under his robe?
You need to raise your prices — then the shoplifters will think your merchandise is worth stealing! At least you'll have some turnover…
Actually, business has improved. Reducing losses is as good as increasing income. (Even better- you pay taxes on income, but losses are yours!)
He should get some better stuff to steal.
comicgos :"That's when you know business is really bad!"
Josh: Amen brother (or sister)!
When I was stationed in New Jersey, there was a store that had you put a quarter in a slot in the shopping cart. You use it and when your done, you put the cart back where it belongs and you get your quarter back. Never had to deal with carts running all over the parking lot. I wonder if it would work here in Summerville, SC.
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text:
July forecast unfolding...
Tuesday, October 04, 2016
Thursday, July 14, 2016
XAU Oct/Nov 2016 Low
This forecast is in agreement with Eric Hadik's work for a low later this year and will be an excellent opportunity to buy gold and silver and their stocks at a lower price. UPDATE: The link below shows the gold stock bullish percent chart I posted on Traders-talk.com , is now turning down, the weekly gold chart looks to have an impulsive bearish candle stick on it, I doubt gold and gold stocks will go any higher now but anything is possible so stay nimble. http://www.traders-talk.com/mb2/index.php?/topic/164975-bullish-percent-gold-stock-chart-turning-down-octnov-low-coming/
Posted by Russ at 10:59 AM 2 comments
XAU Oct/Nov 2016 Low
This forecast is in agreement with Eric Hadik's work for a low later this year and will be an excellent opportunity to buy gold and silver and their stocks at a lower price. UPDATE: The link below shows the gold stock bullish percent chart I posted on Trader-talk.com , is now turning down, the weekly gold chart looks to have an impulsive bearish candle stick on it, I doubt gold and gold stocks will go any higher now but anything is possible so stay nimble. http://www.traders-talk.com/mb2/index.php?/topic/164975-bullish-percent-gold-stock-chart-turning-down-octnov-low-coming/
Posted by Russ at 10:59 AM 0 comments
Sunday, July 10, 2016
Friday, July 01, 2016
Housing Index Low 2020
On Traders-Talk in early 2008 I posted a chart that predicted a big low for the US housing market in spring 2009, now the same housing index is showing another big low coming right on Martin Armstrong's Pi Cycle Model's next low....
Posted by Russ at 6:38 AM 0 comments
Tuesday, June 28, 2016
Gold with monthly ribbon still not positive
Posted by Russ at 12:02 PM 0 comments
Saturday, June 25, 2016
Silver 16 Year Uptrend held support last winter
Silver should keep going up into at least 2018-2020, Eric Hadik is now looking for a correction in the precious metals into next fall which will then be a second opportunity to get into the metals after last winter's lows.
Posted by Russ at 10:59 PM 0 comments
Saturday, June 18, 2016
Gold Bugs Index High Early 2018
This projection has been on my radar for many months, it now looks quite possible that the Gold stocks have seen their low and will break out of the big wedge without testing the lower line of that wedge again, this is of course in contradiction to Armstrong's strong dollar prediction because it seems quite unlikely that both the dollar and gold can go up together.
Posted by Russ at 10:25 AM 2 comments
Saturday, May 14, 2016
US Dollar Index HUGE Bull Flag
This chart going back to the 1960's of course is in support of Marty Armstrong's bullish view going into the near future, the far future is probably extinction by debt. It appears that the consolidation of the past year is a back kiss of the top wedge line, if correct this means Gold will collapse hard.
Posted by Russ at 6:42 AM 6 comments
Thursday, May 05, 2016
Sunday, May 01, 2016
Gold/Euro final low Jan 2018
This chart is in agreement with Martin Armstrong's latest work which says that we are seeing a reaction rally in the Euro now that is not going to last, once the Euro turns back down then the Dollar will rally hard into 2018 driving Gold back down, so Martin's argument is that this is a sucker rally in Gold that will end sucking many in and then will be the fuel for driving it back down as stop losses kick in.
Posted by Russ at 10:02 PM 6 comments
Silver is Breaking Out
Posted by Russ at 1:25 PM 0 comments
Thursday, April 21, 2016
XAU Late June to Early July High
After a high this should be followed by a low into Oct/Nov. 2016
Posted by Russ at 2:36 AM 5 comments
Canadian Dollar July. 2016 high
Posted by Russ at 2:34 AM 0 comments
Monday, April 11, 2016
Friday, March 18, 2016
Oil - Should rally into May 2016
Oscillator is pointing at May for the end of the bull run in Oil.
Also note Martin Armstrong says oil has to get above the 45 and 49 dollar areas in order to reach for the 70 level into May.
Also note Martin Armstrong says oil has to get above the 45 and 49 dollar areas in order to reach for the 70 level into May.
Posted by Russ at 3:15 AM 0 comments
Saturday, February 13, 2016
OEX SP100 Major Low Oct. 2017
OEX, EURO and XAU charts below are all pointing to major lows in Oct. 2017...'The Year from Hell" as MA has called it, this should then lead to the Slingshot move with the US stock markets going into the Phase Transition and Gold skyrocketing.
Posted by Russ at 7:23 PM 0 comments
Euro Oct. 2017 Major Low
Euro is in agreement with XAU and SP100 for a major low in Oct. 2017 which is in agreement with Marty Armstrong's view that the downtrend will continue into 2017 - "The Year from Hell"!
Posted by Russ at 6:59 PM 0 comments
Friday, February 12, 2016
XAU Oct. 2017 Major Low
This xau chart is very powerful in its relationships and shows there should be a big panic crisis low in markets during that time, I also have a big low for the the Dow then so that may be the bottom of for the dow which will then be Martin Armstrong's slingshot move that then propels the dow into a phase transition skyrocket move and starts gold off into its huge run up as confidence is lost in the major governments of the world.
Posted by Russ at 12:16 PM 4 comments
Thursday, February 11, 2016
Saturday, February 06, 2016
Wednesday, January 27, 2016
Thursday, January 07, 2016
Dust Hi Spring 2016
Posted by Russ at 10:22 AM 9 comments
Friday, December 04, 2015
US Dollar Index Low 2021
Posted by Russ at 2:34 PM 0 comments
Gold spring 2016 low (update)
Posted by Russ at 2:26 PM 0 comments
Wednesday, November 25, 2015
Thursday, November 12, 2015
XAU Projected Hi Dec. 23, 2015
Gold and its stocks are likely bottoming now on a couple of important cycles, this chart has been projecting a high into late Dec...
Posted by Russ at 11:26 AM 5 comments
Friday, October 30, 2015
Platinum has most likely reached its Final Low
I had predicted 1 year ago on this blog that Platinum would bottom in Sept, +/- a month, it looks like Oct. 2 may have been the low. Here is the updated chart....
Posted by Russ at 6:00 AM 0 comments
Sunday, October 11, 2015
Gold Stocks Should Rally into early Nov. 2015
Erik Hadik is looking for |Oct 23 for the peak but I am showing it could go a little longer.
Posted by Russ at 9:16 AM 0 comments
Tuesday, October 06, 2015
Friday, October 02, 2015
Gold - final low in early spring 2016
This projection is in agreement with Martin Armstrong recent radio interview on cknw.com
I will be doing more work on this with Tradestation later.
I will be doing more work on this with Tradestation later.
Posted by Russ at 5:46 AM 0 comments
Saturday, September 26, 2015
Martin Armstrong predicting final low for gold in late 1st Q 2016
listen to sept. 26 at 9 am
Posted by Russ at 5:43 PM 0 comments
Sunday, September 13, 2015
Wednesday, August 12, 2015
GDX Gold Stock ETF possible high into 2016
This chart is contradicting my gold chart, this chart is preliminary, I will be doing some more work on tradestation to confirm which chart is right. Dust's chart is also looking like a big low in early 2016. Notice the large wedge on gdx that appears getting ready to break to the upside. So is Erik Hadik or Martin Armstrong going to be right on this?
Posted by Russ at 4:07 PM 0 comments
Tuesday, August 11, 2015
Friday, July 17, 2015
Friday, June 26, 2015
Saturday, June 20, 2015
Gold Stocks - No buy signal yet...
Posted by Russ at 8:53 PM 0 comments
Thursday, June 04, 2015
Thursday, May 07, 2015
Thursday, April 30, 2015
Wednesday, April 29, 2015
Sunday, April 26, 2015
Gold June Low, 2017 Nov. Peak
The June low for Gold is in conflict with the projected Low for Platinum in Aug or Sept, it should become clearer as we get closer to the times.
Posted by Russ at 9:51 PM 1 comments
Wednesday, April 22, 2015
Friday, April 17, 2015
GDX Bear Flag
Posted by Russ at 11:42 AM 0 comments
Saturday, April 11, 2015
GDX sell signal for April 13-14 2015
I notice that Eric Hadik is also calling for a peak Mid April to be followed by the final lows in Gold this summer which is what I also see. Also note the increased bearishness of the commercials.
Posted by Russ at 5:37 PM 0 comments
Tuesday, March 31, 2015
Ulysses Spacecraft Solar Wind Chart showing sharp decline in solar wind from 1998-2008
from https://www.youtube.com/watch?v=V-StCO6IBEM Author of above video is theorizing that we are headed into a major ice age in 30 years based on the trend of the solar wind and the collapse of the sun's primer fields...
Posted by Russ at 2:24 AM 0 comments
Saturday, March 07, 2015
Martin Armstrong Childhood photo
Posted by Russ at 6:44 AM 0 comments
Gold's weekly stochastic looking negative for Gold
Posted by Russ at 6:34 AM 0 comments
Dust should peak around March 19
The 3 times inverse (of the Gold miners) fund Dust should peak around March 19 for the near term, but gold should bottom later in the summer.
Posted by Russ at 6:16 AM 2 comments
Wednesday, February 25, 2015
Gold's Monthly Slow Stochastic argues bear is over
This chart suggests gold's bear market is over, which means Armstrong and myself would be wrong about a bigger low this summer. I am looking for a rally into the end of this month at least see how things shape up going into March
Posted by Russ at 10:31 PM 0 comments
Tuesday, February 24, 2015
Monday, February 23, 2015
GDX Gold Miners Feb. 27 hi, June Low
These trends are not totally confirmed but they seem to fit some of my other work and also some other people's work I follow...
Posted by Russ at 2:55 PM 0 comments
Tuesday, February 10, 2015
Gann Swing Indicator weekly Sell Signal
Also note the CM indicator at the bottom shows the last rally did not have much strength, look for divergences on that indicator which can be found at the tradingview.com site. That indicator shows whether the bulls or bears are in control. Also notice how gold refuses to get above the 70 period moving average, bears remain in control. The commercials also are still very short and they are usually right.
Posted by Russ at 4:30 AM 0 comments
Friday, February 06, 2015
Gold - Caution new lows may be coming
My main work is showing a big low for gold, platinum, copper, oil, Euro later this year while the US Dollar should peak which is in agreement with Martin Armstrong's work. I am therefore cautioning that the highs may have already been seen for gold. chart link... http://stockcharts.com/h-sc/ui?s=GDX&p=W&b=5&g=0&id=p59612592730
Posted by Russ at 2:14 PM 3 comments
Thursday, January 29, 2015
Microsoft's Demise - Heading for big low in 2019
Martin Armstrong wrote last year about Microsoft's end, his thinking was that because they have cooperated with the National Security Agency and allowed Windows 8 to become a spy tool for the US government that that would lead to their demise and that Armstrong's company could not use Window's computers for their operations as the CIA already tried to acquire his AI computer model and he has since moved it out of the USA so he sure is not going to make it easy for them to hack into his computers using Windows for computers he lets his customers use to access his systems! The other factors affecting Microsoft is that Windows and Portable Computers have been put on the back burner by consumers who have embraced portable devices more and more which are using Android, Apple and Samsung's OS mostly. Also of note is that James Dale Davidson and Lord Rees Moog in their book 'The Great Reckoning' a couple of decades ago wrote that Microsoft would eventually just be a footnote in history, whether that all comes to pass will be interesting to see. Microsoft got its start by luck as Bill Gates mother knew executives from IBM and she put her son in contact with them as they wanted an operating system to compete with Apple, so Gates then went and bought QDOS (quick and dirty operating system) which was a knock-off of Dr. Gary Kildall's 'Dr.Dos' OS which was superior but Gates used dirty tricks to scare people from using it by flashing warnings on screens about its supposed dangers. Microsoft was sued by Gary Kildall and he won but Gates still became top dog and strangely Gary Kildall fell in a bar, struck his head and died.
Posted by Russ at 4:58 AM 0 comments
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text:
- Jean-Baptiste Colbert
- Jean-Baptiste-Donatien de Vimeur, comte de Rochambeau
- Charles-Hector, count d'Estaing
- Charles Gravier, count de Vergennes
- Marie-Jules Dupré
- Pierre-Charles-Jean-Baptiste-Silvestre de Villeneuve
- Marie-Joseph-Paul-Yves-Roch-Gilbert du Motier, marquis de Lafayette
- Armand-Jean du Plessis, cardinal et duc de Richelieu
- François-Joseph-Paul, count de Grasse
- Francis Garnier
Pierre André de Suffren de Saint-Tropez, (born July 13, 1729, Saint-Cannat, France—died Dec. 8, 1788, Paris) French admiral, noted for his daring tactics, who fought the British in Indian waters during the American Revolutionary War.
A Knight of Malta, Suffren de Saint-Tropez served under Admiral C.H. d'Estaing in America and was sent to assist French military operations in India in 1781. In a remarkable series of engagements with British Admiral Sir Edward Hughes off the coasts of India and Ceylon in 1782–83, he disregarded textbook rules and tried, with varying success, to teach his captains to isolate groups of enemy vessels and thus destroy a squadron piecemeal.


text: The models at this year's Dior's Spring 2014 Fashion Show each donned a pair of golden eyebrows, causing excitement and launching a new trend in the beauty community. Seriously, what's more luxurious than literally dripping in gold?! Feeling bold enough to go gold? Here are a few products we suggest to help you achieve the… Continue Reading


text:
Game Credits
|Saints Row 2 (2008)
|("Ridin' In The Black Joint")
Quality Assurance
|Forza Motorsport 6: Apex (2016)
|(Software Test Engineers)
|Forza Horizon 2 (2014)
|(Car Testers)
Developer Biography
There is no biography on file for this developer.
[add bio]
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Related Sites
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text:
94 N. Main Street, Jasper, GA - (706) 253-2457
General news and features
Capitol Reporter
As of last Friday, Georgia's Insurance Commissioner, Ralph Hudgens, had not received a reply from Kathleen Sebelius, secretary of the U.S. Department of Health and Human Services (HHS).
Hudgens had penned a very public letter to the Secretary, requesting a 30-day extension for Georgia's approval of seven company insurers competing to provide health insurance coverage within the Affordable Care Act's (ACA) healthcare exchange program. The letter made reference to "massive rate increases" and requested that Department "show cause" as to why the increases were not justified in light of the ACA. See original Statement from Commissioner Hudgens.
Hudgens' letter was dated July 29 (one day before the Commissioner's deadline to submit his findings to HHS). He requested that a response be delivered on July 30.
According to the letter, of the seven actuaries hired to evaluate the participant insurers' submissions, six had deemed the submissions as "justifiable" within the ACA. One actuary reported that one of the submissions was 11 percent above the justifiable range.
The commissioner cited one instance in which a non-smoking male, aged 24 years, would likely experience an increase in his insurance premium from between 85-198 percent.
Bill Custer, director of The Center for Health Services Research within Georgia State University, believes this estimate is in anomaly. Custer notes that some premiums will rise for certain individuals (most notably for males and young people) in order to spread risk amongst patient population segments.
"The law requires that insurance companies bring in sick people, and bringing in sick people increases risk and costs. However, I don't expect an increase of more than 20 percent in any one class of insured people [in the exchange]."
Custer notes that provisions within the law limit large rate disparities between customer classes. A 3:1 ratio cannot be exceeded (meaning a rate for one class cannot exceed three times the cost of any other rate class).
Transportation Director says previous chaos led to safety issues
Some parents of Pickens County students say the recent changes to the bus transportation policy have left them scrambling to find childcare after school lets out.
But the school system's transportation director Bruce Godfrey said the changes have been put in place for the sole reason of keeping Pickens students safe, not to make it easier on bus drivers or the system as a whole.
A post on The Pickens County GOP website gained national attention on Comedy Central's Colbert Report. The screenshot was taken from the Comedy Central website.
A Thursday, July 25 post on the Pickens County GOP website caught the eye of Comedy Central's Steven Colbert, who on the Thursday, Aug. 1 edition of the Colbert Report chaffs the local political party.
But a representative with the local GOP says the comments weren't originally theirs, and that they simply reposted a story from another website to "provide information and to educate people about news going on in the country."
Two employees of the Younglife Camp in the Grandview area were rescued by a Forsyth County Swiftwater Rescuse team this morning on the access road leading to the camp. See full rescue of first stranded person from YouTube.
The two employees were in a truck that washed downstream lodging on a formed island that developed after a flash flood swept through the narrow creek channel, blowing out culverts.
See short video of rescue of second person at our facebook page.
Graduation and Life
Preparation for All
This week's Progress contains a Back to School special section that the Progress partnered with the school system to produce.
Information includes:
• Columns from all principals with basics about their schools
• Accreditation Information
• Curriculum Information
• Lunchroom/ Meal Plan Information
• Transportation
• Technology
• Homeroom Class Rosters for all schools, grades


text:
Sikh Hailed as Hero for Helping Arrest New York Terror Suspect
A Sikh bar owner in the US is being hailed as a hero for helping capture the 28-year old Afghan-American wanted for the weekend bombings in New York and New Jersey.September 20, 2016, 10:18 am explore: India
Obama Drop-in For Pork Soup Stuns Vietnam Street Shop Owner
She has ladled out countless bowls of her pork noodle soup, but the owner of a Hanoi streetside restaurant says she was stunned when Barack Obama strolled in, pulled up a plastic stool and slurped down Vietnam's famed "bun cha" delicacy.May 25, 2016, 9:47 am explore: Lifestyle
Delhi: Lawyer Shot Dead After He Refused to Accept Bribe
A government lawyer in Delhi, MM Khan, was gunned down after he refused to accept a Rs 4 crore bribe from a hotel owner and compromise in an ongoing case. The MD of the Connaught Hotel hired contract killers to eliminate the NDMC lawyer. Six people have been arrested but questions are also being raised whether Khan's own department betrayed him.Nitisha Kashyap, May 18, 2016, 9:02 pm explore: India
New Research Reveals Dogs Hate to be Hugged
A new research has revealed that most dogs hate getting hugged but the dog owners have refused to except this theory. CNN's Jeanne Moos with this report.April 27, 2016, 3:21 pm explore: World
Huawei-Google Nexus 6P is good but not the great phone it is said to be
With Android Marshmallow goodness and top-notch specs, the Nexus 6P sails smooth but runs into a little rough weather.Soumyadip Choudhury, April 15, 2016, 12:47 pm explore: Tech
Pak-American US eatery owner forced to remove anti-Hindu signs
For the past six months, Dar's Dairy Queen restaurant posted signs bashing Hinduism as a force of racism. Some of the messages, displayed on tall panels, mentioned Hinduism specifically and accused it of being based on racism.April 1, 2016, 3:33 pm explore: World
Delhi model kills self; husband arrested for alleged torture
A 25-year-old Priyanka Kapoor, married to a Delhi-based pub owner Nitin Chawla, was found dead in posh Defence Colony area in the wee hours on Saturday.Nitisha Kashyap, March 28, 2016, 11:21 pm explore: India
'Socialite' kills self; husband held for suspected dowry harassment
Priyanka, owner of an event management company, was found dead in the wee hours on Saturday.March 27, 2016, 6:22 pm explore: India
Man jailed for abusing pet dog in New Zealand
The dog, named Ben, looked like 'a skeleton covered with fur', with bones clearly seen through his skin. (File photograph)February 4, 2016, 8:19 pm explore: World
Oommen Chandy alleges some bar owners behind allegations against him
The prime accused in the solar case Saritha S Nair had on Wednesday targeted Chandy and Power Minister Arayadan Mohammed while deposing before the Justice Sivarajan Commission in Kochi, probing the case.January 28, 2016, 12:32 pm explore: Politics
Kerala Excise Minister K Babu quits over bar bribery scam
A bar owner had alleged that Babu had demanded a bribe of Rs 10 crore and that he gave him Rs 50 lakh for giving a reduction in bar licence feeibnlive.com, January 23, 2016, 5:47 pm explore: India
Indian-origin takeaway owner stabbed in UK
Narinder Sidhu, who owns fish-and-chips shop in Oldbury in UK was stabbed five times and left for dead by an anti-social. He survived the attack.January 17, 2016, 9:25 pm explore: World
This adorable apology by a dog to his owner can melt any heartSeptember 19, 2015, 4:56 pm explore: Buzz
Indian smartphone owners focus more on price than on features
Within the next two years, India will have overtaken the USA as the world's second-largest smartphone market.August 13, 2015, 10:31 am explore: Tech
Amendment in Real Estate Bill may lead to imprisonment of errant builders
In the current version of the bill, punitive action for various offences is mostly restricted to financial penalties, and not imprisonment.July 3, 2015, 10:04 am explore: India


text:
Upcoming Activities
- Yoga with We Yogis Thursday, Oct 27 from
- Yoga with We Yogis Thursday, Nov 03 from
The most important stroke in the game of golf is the final putt, so they say. We know you usually ace every hole, so here's your chance to putt like us amateurs. Bring your favorite club and enjoy the Putting Green on the East Lawn anytime of the day.
All the health and fitness programs, presented by Cigna.


text:
Valentino's Life Story Might Become a Musical
How could anyone fight this?
One of the best fashion documentaries ever, arguably even better than the September Issue and Lagerfeld Confidential, was Valentino: The Last Emperor. André Leon Talley may have been better in that movie than he was in September Issue, which was even about his own employer. The only thing better than the film itself would be, as was the case with Legally Blond, the musical version of it. The Telegraph reports:
"We're looking at the possibility of taking my story to Broadway, as a musical," the designer, whose full name is Valentino Garavani, told La Repubblica newspaper yesterday.
Valentino: the musical [Telegraph UK]


text:
Vibrational Medicine: New Choices for Healing Ourselves
Bear & Company, 1996 - Health & Fitness - 601 pages
Now updated, this bestselling combination of ancient wisdom and new physics is a definitive introduction to traditional and alternative health care for modern times. Dr. Gerber presents an encyclopedic treatment of energy fields, accupuncture, Bach flower remedies, crystals, radionics, chakras, meditation, and particle physics.
What people are saying - Write a review
Vibrational Medicine: New Choices for Healing OurselvesUser Review - Not Available - Book Verdict
This revision of an alternative medicine title from 1988 combines ancient techniques with modern philosophy. A new chapter updates the information. Read full review