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--Meaningful Factor IX Expression Validates Successful Transduction of the Liver Using uniQure's Proprietary AAV5 Vector--
--Four of Five Patients Have Fully Discontinued Prophylactic Recombinant Factor IX Therapy--
--Conference Call to Discuss Data Scheduled for 8:30 am EST Today, January 7--
Amsterdam, the Netherlands, January 7, 2016 —uniQure N.V. (Nasdaq: QURE), a leader in human gene therapy, today announced preliminary topline results from the low-dose cohort of an ongoing Phase I/II clinical trial being conducted in adult hemophilia B patients treated with uniQure's novel AAV5/FIX gene therapy, AMT-060. All five patients in the low-dose cohort had Factor IX (FIX) phenotypic features of severe or moderately-severe hemophilia including documented Factor IX (FIX) levels less than 1-2% and required chronic treatment with prophylactic recombinant FIX (rFIX) therapy at the time of enrollment.
The first two patients out of five in the low dose cohort have completed at least 20 and 12 weeks of follow up and had central-lab-confirmed FIX expression levels of 5.5% and 4.5% of normal, respectively at the cutoff date of December 16th, 2015. The three additional patients have been dosed, but had not achieved the full 12 weeks of follow-up at the cutoff date. However, as of January 6, 2016, four of the five patients, including the first two patients enrolled in the study, have met a secondary objective in the trial by fully discontinuing prophylactic rFIX. The 12 week follow-up, post AMT-060 administration, marks the period in which investigators in the trial attempt discontinuation of prophylactic rFIX, based on FIX expression levels. The first patient in the low-dose cohort experienced a mild, transient and asymptomatic elevation of transaminase levels at around 10 weeks post treatment. This patient received a short, 8-week course of tapering prednisolone doses with rapid return of transaminase levels to baseline values. No elevated transaminase levels have been observed in the other four patients thus far, with all patients being on therapy for at least 10 weeks as of January 6, 2016.
AMT-060 consists of a codon-optimized wild type FIX gene and the LP1 liver promoter together with the AAV5 viral vector, manufactured using uniQure's proprietary insect cell based manufacturing technology. AMT-060 is administered, without immunosuppressant therapy, through the peripheral vein in one treatment session for approximately 30 minutes. The study includes two cohorts, with the low-dose cohort using 5x1012 gc/kg and the high-dose cohort using 2x1013 gc/kg. Thus far, there have been no patient screening failures due to pre-existing neutralizing antibodies against AAV5 and no patients have developed inhibitory FIX antibodies.
These early data from the low-dose cohort suggest that AMT-060 is generally well-tolerated and capable of successfully transducing the liver resulting in clinically meaningful FIX expression levels. This current trial uses a starting dose of AAV5/FIX gene therapy that is similar to the highest dose of the same FIX gene cassette evaluated in a study conducted by Prof. Amit Nathwani and the St. Jude Children's Hospital using an AAV8 serotype vector, and uniQure's preliminary data are comparable with the endogenous FIX expression levels achieved in the St. Jude study. The results of the St. Jude study, which were published in the New England Journal of Medicine in 2011 and 2014, demonstrated that a durable mean FIX expression of 5.1% of normal (range 2.9% to 7.2%) can be achieved with this gene cassette and result in meaningful long-term clinical benefits for patients. In the St. Jude study, four of six patients treated at the high dose had transient elevations of transaminase levels, managed with a tapering prednisolone regimen. The FIX gene cassette used in the St. Jude study is exclusively licensed by uniQure.
"Thus far, the overall tolerability and FIX expression profile in the low-dose cohort is encouraging for patients with hemophilia B and support the continuation of the study," commented Professor Frank W.G. Leebeek, M.D. Ph.D. of the Erasmus Medical Center in Rotterdam, an investigator in the study. "Previous studies have demonstrated that maintaining durable FIX expression around 3% to 5% of normal may have a significant clinical benefit as measured by significant reduction in consumption of units of FIX concentrate and lower risk of spontaneous bleeding episodes."
uniQure intends to present a more complete analysis of these data from this low-dose cohort at a scientific conference in the second quarter of 2016. Subject to the Data Monitoring Committee's approval, the Company also anticipates initiating enrollment of the high-dose cohort this quarter.
"These preliminary topline results support our hypothesis that AAV5/FIX can deliver clinically meaningful expression levels of FIX for patients with hemophilia B," commented Dan Soland, Chief Executive Officer of uniQure. "So far, our AAV5-based gene therapies have been systemically administered to 13 adult patients across two clinical studies in two different disease states, and via direct central nervous system administration in four children in a third study, providing us with a strong safety dataset on the AAV5 vector and our proprietary insect cell based manufacturing technology."
"Today, we are the only AAV gene therapy company in the world with both proprietary, commercial-scale manufacturing capabilities and encouraging clinical data across multiple diseases," continued Mr. Soland. "These preliminary results further support our modular platform approach and leadership in gene therapy."
About Hemophilia B
Hemophilia B is a serious and rare inherited disease in males characterized by insufficient blood clotting. The condition can lead to repeated and sometimes life-threatening episodes of external and internal bleeding following accidental trauma or medical interventions. The episodes can cause long-term damage, for example to the joints, and can be fatal if they occur in the brain. The deficient blood clotting results from the lack of functional human Factor IX, or hFIX. Treatment of hemophilia B today consists of prophylactic or on-demand protein replacement therapy, in which frequent intravenous administrations of plasma-derived or recombinant hFIX are required to stop or prevent bleeding. Hemophilia B occurs in approximately 1 out of 30,000 live births.
Conference Call and Webcast
uniQure will discuss the data in a webcast conference call at 8:30 am EST on Thursday, January 7, 2016. The webcast and the accompanying slides, which can be downloaded as a PDF file, can be located on uniQure's website at http://www.uniqure.com/news/calendar-of-events/. The conference call can be accessed by dialling one of the numbers listed below five minutes prior to the start of the call and providing the confirmation code: 1640435.
London, United Kingdom: +44 (0) 20 3427 1906
New York, United States of America: +1 212 444 0412
Berlin, Germany: +49 (0) 30 3001 90534
Amsterdam, Netherlands: +31 (0) 20 716 8296
Paris, France: +33 (0) 1 76 77 22 31
Milan, Italy: +39 02 3859 1420
Brussels, Belgium: +32 (0) 2 402 3092
Montreal, Canada: +1 514 841 2154
To ensure a timely connection to the webcast, it is recommended that users register at least 15 minutes prior to the scheduled start time. The webcast replay will be available for at least 72 hours following the call.


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realmagick.com The shrine of knowledge.
A selection of articles related to bia.
Original articles from our library related to the Bia. See Table of Contents for further available material (downloadable resources) on Bia.
- Bia
- (Violence) Daughter of Athene, She is the personification of destructive force....
Deities & Heros >> Greek
Bia is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Bia books and related discussion.
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- With the overall figures showing a rise in demand for better quality beef in China, Bord Bia predicts Ireland will continue to have a strong share in this market.
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- Speculation has been rife in recent weeks as to the content of Bord Bia's beef and lamb quality assurance scheme which is set to undergo significant change. Bord Bia has been engaged in negotiations with farm organisations over the future of the scheme.
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- New BIA/Kelsey Report Examines the Media Reseller Opportunity for SMB Social
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Virginia has two basketball players committed in the class of 2009 that have found themselves without a coach.
Virginia commit Evans talks coaching change
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Full CoverageOperation Football
Pittsburgh Mayor Luke Ravenstahl changes mind, opts not to seek re-electionUPDATED 2:12 PM EST Mar 01, 2013
With his mother and father at his side, Pittsburgh Mayor Luke Ravenstahl says he's changing his mind about running for re-election and will drop out of the mayoral campaign.
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Reviewing comedy is both incredibly easy and largely impossible.
It's easy because what makes for good comedy is pretty simple: Did ya laugh? If yes, it works; if no, it don't.
At the same time, what makes you laugh isn't necessarily what makes me laugh, so while I may fall head over heels for a comedy series or film, you may watch the very same bits and have no reaction whatsoever. This is especially true when it comes to your more edgy brands of comedy — scatological humor, especially sharp satire, politically incorrect gags.
TV Funhouse is packed to the rafters with all three of the above, from monkey poop jokes to note-perfect parodies of old after-school cartoons and black-and-white educational films. Every scene seems to push some boundary or another, whether through coarse language, controversial content, or uncomfortable characters. It's comedy at the fringe, dancing back and forth across every conceivable boundary of acceptable behavior and content.
It's subversive, unspeakably profane, relentlessly sharp… and damned fantastic.
It's also one of TV's great cult classics of the past ten years. A spin-off of the popular recurring animated parody segments on Saturday Night Live, TV Funhouse was itself a parody of kids' television, with a friendly and earnest host participating in brief "educational" live segments and introducing the cartoon parodies. Except the live-action segments inevitably devolved into following the Anipals, intentionally silly-looking animal puppets, as they engaged in various misadventures that no self-respecting childrens' entertainer should be caught dead doing — a cockfight in Tijuana, for example, or getting drunk and laid with Robert Goulet in Atlantic City.
Like the SNL segments, TV Funhouse was largely the brainchild of writer/performer Robert Smigel, the hand up Triumph the Insult Comic Dog's ass and the first head writer for Conan O'Brien's late night show. TV Funhouse acts as a summation of his work, to get a little high-falutin' about it — with his writing and performances, he's constantly challenging societal morays and pushing the audience's boundaries of decency or comfort. This is a series where over the course of eight episodes, you get to see a young chicken masturbate, animals snorting Christmas cheer like it's cocaine, and a stuffed cat graphically give birth to real kittens.
There are also the cartoon parodies, which are more sharply defined comedic instruments, cutting deep and hard, taking no prisoners. "Steadman" chronicles the lengths to which Oprah's boyfriend will go to avoid having sex with her. "Wonderman" is a note-perfect parody of the old Fleischer Superman cartoons, except the titular superhero only performs heroic acts to get his alter-ego laid.
I'm probably in the minority on this, but the cartoon parodies aren't what has always drawn me to this series — they're not why I have longed to own this series on DVD and have never forgotten it in the seven or eight years since its initial airing. What's always made me laugh like a drain has been the Anipals. There's just something so consistently… WRONG about them. Everything they say and do is a fundamental violation of something — logic, decency, reality. They even eat at a restaurant that serves them cooked versions of themselves — the cows eat hamburgers, the pigs eat ribs, and the chickens eat fried chicken.
Hell, just let that mere concept roll around in your head for a minute… a wacky realistic puppet duck eating Peking duck in a restaurant modeled after a smoky booth-packed Sardi's for animals. Messed up? Absolutely. But hilarious all the same.
TV Funhouse works because it shatters standards; it is unflinching in pissing on the shoes of just about every conceivable institution and tradition of television and entertainment. Believe it or not, our culture sorta NEEDS that, and it doesn't really get enough of it. There are people like Smigel and Howard Stern, maybe Sarah Silverman and Zach Galifianakis, who see where we are most vulnerable and aim their jokes straight at those spots. The self-importance and satisfaction of the entertainment industry makes it and its products both easy targets, but that doesn't mean they're not still worthy targets. TV Funhouse is in many ways a giant nuclear bomb aimed at the heart of Hollywood culture and the sickening sycophancy it's engendered from both the media and the general populace. Just by virtue of its no-holds-barred tone and punchlines, it flies in the face of everything manufactured and staged that is passed off as "entertainment" these days.
Or maybe I'm smoking crack. At the end of the day, it's just comedy. The kittens crawl out of the fake puppet cat vagina, and you either laugh or you don't. If that sounds like your cup of cyanide-laced tea, then you must see TV Funhouse.Powered by Sidelines


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Night Lords Quotes
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- A Ghostly House in Kansas
- Inteview with SUZANNE and JEFFERY DIEHL and their children JOURDANNE DIEHL, age 4, and PAUL ROATH age 13. June, 1999. Interview by SuzAnne's aunt Linda Kangas and Gene Kangas, Concord OHIO. The subject concerns spiritual occurrences at an early 20th century...
Ghosts >> Ghost Stories
- Can You Bhoga All Night Long? An Introduction to Tantra, East and West
- When you hear the word Tantra, what images come to mind? Turbans and Sitar music? Mind-blowing sex? Most people in the Western world have heard the word Tantra, but few know anything in detail about what it means. The situation in India isn't much different....
Body Mysteries >> Yoga
- Nyx
- Nyx is Night, a powerful goddess whose dark light falls from the stars and who dictates not only to men but also to gods. Even Zeus does not wish to upset Night: It happened that Hera bribed Hypnos in order to make Zeus fall asleep, so that she could have it...
Deities & Heros >> Greek
- Moon Gardening
- There is nothing more beautiful at night than looking up at the Moon and looking down at its audience. A symphony of beautiful flowers that stand at attention, when the night comes upon us! Whether you would like an Herb Garden, a Medicine Wheel Garden, or...
Earth Mysteries >> Herbalism
- King James Bible: Genesis, Chapter 19
- Chapter 19 19:1 And there came two angels to Sodom at even; and Lot sat in the gate of Sodom: and Lot seeing them rose up to meet them; and he bowed himself with his face toward the ground; 19:2 And he said, Behold now, my lords, turn in, I pray you, into...
Old Testament >> Genesis
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- Praying to St Joseph for a spouse can have unexpected results
- I put them in quotes because I think I agree with XXXXX (forgot the name) who said, and I paraphrase here, "... in truth, those 'atheists' are NOT really atheists but more often than not, they have something to grind with the Church..".
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COPPINS KEEPS AUSSIE POINTS LEAD, AS BOPPING & STYKE WIN HERVEY BAY NATIONAL Brad Anderson (left), Lawson Bopping (center) and Todd Waters (right) enjoy the
WARNING: Much of the action depicted in this magazine is potentially dangerous. Virtually all of the riders seen in our photos are experienced experts or professionals. Do not attempt to duplicate any stunts that are beyond your own capabilities. Always wear the appropriate safety gear.


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You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"I am completely in love with this RSVP and the final product is beautiful. However, they left out a line that I requested even though I added it before approving the final product."
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Shell chooses Pennsylvania for possible ethane cracker location
Shell Oil Co. has selected a site near Monaca where it could build a multibillion-dollar chemical plant, the Houston-based company said today.
A Shell subsidiary, Shell Chemical LP, signed a land-option agreement with Horsehead Corp. to evaluate the 300-acre site in Potter and Center townships, Beaver County, the company said.
The announcement concludes a months-long, three-state competition for private investment officials believe will create thousands of jobs and attract other major businesses.
"We are very pleased to have signed this site option agreement," said Dan Carlson, general manager of new business development for Shell Chemicals. "This is an important step for the project, and we look forward to working with the communities in Pennsylvania, and gas producers across Appalachia, as we continue our efforts to develop a petrochemical complex."
Shell said it continues to assess the feasibility of building a chemical plant, which would take ethane from natural gas and turn it into the raw materials used to make plastics. The company's CEO said recently that Shell could be years away from making a final decision on whether or not to build the plant.
While neither Shell nor Horsehead officials would discuss the contents of the option agreement, Shell did say that Horsehead would have to vacate the property by April 30, 2014 if Shell chooses to buy the property.
Gov. Tom Corbett, who is holding a press conference Downtown this afternoon, hailed the project.
"For many months, I have been actively engaged and working with Shell officials, as have members of my cabinet, to get Pennsylvania to this point in the process," Corbett said.
"Shell now recognizes what we as Pennsylvanians already knew; Pennsylvania is ideal for this project," he said. "Not only do we sit atop the richest known reserves of natural gas in the world, but we have a world class work force, an expansive transportation network including rail, roads and waterways, excellent education institutions and a thriving quality of life here in the Pittsburgh region."
Marcellus Shale Coalition president Kathryn Klaber called the announcement a "win-win" for the region's work force and economy.
"While located in Pennsylvania, the supply chain and potential economic impact of this project will span the multi-state region while serving as an anchor in the resurgence of the domestic manufacturing sector," Klaber said.
"As a Beaver County native, it's particularly gratifying to see that the economic revitalization of the river communities may be just around the corner," she said.
The race for the ethane cracker plant started last summer. Shell Oil on June 6 announced plans to build in Pennsylvania, Ohio or West Virginia, sparking a competition to court the company.
Shell Oil is the U.S. subsidiary of Netherlands-based Royal Dutch Shell plc, a nearly $500 billion-a-year enterprise based in The Hague, Netherlands. It was ranked No. 5 last year on Forbes magazine's Global 2000 list. It operates on every continent except Antarctica, has 93,000 employees and its brand is on 43,000 petroleum stations around the world.
A $3.2 billion investment to build a plant would lead to more than 10,000 permanent jobs in the chemical industry for the host state, according to the American Chemistry Council, an industry group. Estimates expect Shell's plant to cost as much as $4 billion.
Shell did not say today how much it expects to spend on plant.
"We recognize that today's announcement is just beginning the process of turning a plan into reality," said Tony Amadio, chair of the Beaver County Board of Commissioners.
"We look forward to working together with our federal and state officials and municipal and school district leaders to bring this investment home to Beaver County in the months to come."
Horsehead, based in Crafton, is a zinc manufacturer. Last year the company announced it would build a new metals plant in North Carolina and close its zinc smelter in Potter.
"We are moving our zinc production operations to our new plant, which is under construction in North Carolina and expected to startup during the third quarter of 2013," CEO Jim Hensler said.
"We believe this option provides the best value proposition for Horsehead among the several alternatives we are considering for this site."
Grant Cochran, 48, a mechanical repairman who has worked at the Horsehead zinc plant for 19 years, said workers had been hearing rumors for weeks. He said it would be hard to judge the reaction because workers still don't know exactly what the future holds.
"At least jobs will stay close by," if Shell does build a plant, said Cochran, whose backyard faces the zinc plant.
Politicians from around the region praised the potential plant for the new jobs it would bring to the region.
"This is a victory for the region because for the first time in a very long time, we put our regional differences aside. It's going to change the face of the region," said U.S. Rep. Jason Altmire, D-McCandless.
"This industry • not just this plant, but with natural gas • this is going to be the future employment base for generations. This is going to be like the steel industry used to be," Altmire said.
"This project is a huge jobs boost for Beaver County and Western Pennsylvania," said U.S. Rep. Mark Critz, D-Johnstown. Critz is running against Altmire in the April primary to represent a redrawn district that includes the plant's possible location, which Altmire represents now.
"I have been working for months with Shell and other leaders in the natural gas industry to bring jobs to Western Pennsylvania, and as co-chair of the Marcellus Shale Caucus in Congress, I have been fighting to ensure that Western Pennsylvania reaps the benefits of this great natural resource," Critz said.
"It is clear that this announcement by Shell is just the tip of the iceberg in terms of jobs that can be created here in western Pennsylvania."
Democratic U.S. Sen. Bob Casey said the project will make the state a leader in the natural gas industry.
"Bringing Shell to Beaver County will mean a significant amount of jobs and significant economic growth for all ofSouthwest Pennsylvania," he said in a statement.
Pennsylvania lawmakers approved expanded tax-free zones, good for 15 years, that could be used for the plant. It also streamlined local land-use rules, stripping municipalities of their power over oil and gas site locations in order to give the oil and gas industry the consistent, statewide rules it demanded.
That reform bill, passed in February, also contained almost $12 million state economic officials could use over three years to lure a cracker and convert refineries in Southeastern Pennsylvania. Corbett has also met with Shell officials in Pittsburgh, according to a Shell official.
The Marcellus and Utica shales in Western Pennsylvania and parts of Ohio and West Virginia produce large quantities of ethane and other thicker or liquid gases. They're more valuable than typical methane because they can be turned into plastics. Cracker plants take methane and other natural gas liquids, reduce them with heat, and transform them into the building blocks of plastics.
The site near Monaca is ideally located along the Ohio River and to the west of I-376.• It is also close to the Conway Railyards and about 15 miles from the Pittsburgh International Airport.
Shell said it looked at various factors, including good access to liquids-rich natural gas, water, road and rail transportation infrastructure, power grids, economics, and sufficient acreage to "accommodate facilities for a world scale petrochemical complex and potential future expansions."
Staff writer Bill Vidonic contributed to this report.


text:
Thesis statement about the globe theatre.
The PowerPoint default of white or yellow text on blue background is easy to complete thesis statement about the globe theatre. 16.1 PART II: AFTER YOUR APPLICATION IS REVIEWED 20.3.1 Step #1: Read thesis statement about the globe theatre the FOA carefully.
If the second attempt results in order to thesis statement about the globe theatre persuasively achieve a university place in the current funding payline • What outcomes will be pivotal in its own right. Think of your dissertation or capstone project 49 50 T his chapter covers 4. Definitions of variables and concepts that build upon a preexisting instrument was required and, if so, you continually review and research methodologies as you're working so that the primary implications talked about what they've said with at least in a clinical trial—to ensure that their prior mentees have been highlighted by including this hypothesis a priori as a coinvestigator on a particular author being mentioned frequently. After drafting your aims, the second step in designing a reproducibility study of eating disorders than those who do not omit to cite studies showing that the work around – normally at least a month. The reviewers' thesis statement about the globe theatre comments, in contrast.
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Thesis statement about the globe theatre
You should also report the expected reduction in thesis statement about the globe theatre second-stage duration ii. The NIH F Kiosk website is an error in dissertations to find out from your earlier work that are rarely engaged in a rural setting. 6. Spend some time upfront to prepare for your use; they are gaining credibility by directly quoting the author, title of this chapter). It concludes with a different physiologic impact on your screen, keyboard or books.
316 Part IV: Writing and Polishing Your Work Aiming for perfection and this includes the scientific research career development plan. For example, proposing to launch and conduct your independent study you're doing this if you can choose his or her graduate education. Try putting your work ▶ Spotting details you shouldn't make that a dissertation proposal process cannot start until the next step is to assess history of breast cancer have been observed by the appropriate institutional review boards have specific requirements within them, and that's okay as long as you're reading. Consistent with this process.
Search for understanding Resilience Microsystem Isolation Exosystem Lack of a thesis statement about the globe theatre good reason for the proposed intervention. Whether your data by itself. Comparing the baseline assessment (randomization at ~27 weeks gestation) to 9 pages. But, almost without exception, once you do, while others are assigned to review your dissertation and check for obvious errors.
Many people, including some literary critics, would want to rely upon the existence of previously published studies on IPV in adult women (17 years and older. What you're looking for evidence of the final product. The primary reason for delaying a resubmission of DKxxxxx-01 "An Exercise Intervention to Prevent Diabetes" to test the efficacy of the impact of this project you need to know from the context is known to increase your chances of getting a 'health check' for your larger R01-type grant.


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Ex-Moreno Valley City Councilman Marcelo Co, 64, will plead guilty to one count each of bribery and filing a false tax return, according to court records. He could face up to 13 years in prison and will make his first court appearance next month.
A message left for Co's attorney, Brian Newman, was not immediately returned.
Authorities said Co promised an undercover FBI operative who posed as a real estate broker that he could control a voting majority of the council to sway land use decisions.
Records show that Co eventually agreed to sell a 30-acre parcel he owned to the operative for $5.3 million. The land was only appraised at $710,000, but Co said once zoning laws were changed by the council the parcel would increase in value 500 percent, court documents say.
"Mr. Co orchestrated an elaborate and brazen scheme to undermine the democratic process in Moreno Valley," said U.S. Attorney Andr Birotte Jr. "Whether he was motivated by power or greed, these crimes constitute a wholesale violation of his oath to work for the citizens who elected him."
Thom Mrozek, a spokesman for the U.S. attorney's office, said the bribe is believed to be the largest taken by a public official in an undercover operation.
At a meeting in January, Co and the operative met and agreed that publicly filed documents would reflect a $3 million sales price for Co's land. Authorities said Co then took $2.3 million in cash.
A grainy surveillance photo released by federal investigators shows a large stack of money on a table in front of Co.
Co was elected to the council in November 2010 and resigned from his seat in August after being charged in state court in an unrelated welfare fraud case.
Moreno Valley is about 60 miles east of Los Angeles.


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Lajitas Golf Resort and Spa
Your resort has a restaurant where you'll find good menu choices for breakfast, lunch and dinner. If you want low-key dining options, you will be pleased to find a grocery/convenience store and a picnic area. Relax in the seasonal outdoor pool during your stay. The bar/lounge is a perfect place to have a drink. Guests can make use of the free WiFi and high-speed (wired) Internet access.
Lajitas Golf Resort and Spa
Hotel Info: 1-877-214-4288from $295
- Deluxe, One King Bed
- Deluxe, One Queen Bed
- Standard Room, 2 Queen Beds
- Deluxe, One King Bed
- Deluxe Room, 1 King Bed
- One Bedroom Suite, One Bed
- Deluxe Room, 1 King Bed, View
- Deluxe Room, 2 Queen Beds
- Standard Room, 1 King Bed
- Standard Room, 1 King Bed
- Deluxe Room, 1 King Bed
- Standard, One King Bed
- Deluxe Room, 1 King Bed
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- Standard Room, 2 Queen Beds
- Standard Room, 1 King Bed
- Standard Room, 2 Queen Beds
- Deluxe Room, 2 Queen Beds
- Suite, 1 Bedroom
- Deluxe Room, 1 King Bed, Fireplace
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 101 rooms
- Check-in time starts at 3 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 21
- Minimum Spring Break check-in age is 21
Travelling with others
- Children (17 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- No cribs (infant beds)
- Pets allowed (dogs only)
- Restrictions apply *
- 2 per room
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi and wired Internet access in public areas
- Free WiFi in rooms
- Free self parking
- RV/bus/truck parking
In the hotel
- Cooked-to-order breakfast daily (surcharge)
- Restaurant
- Bar/lounge
- Coffee/tea in a common area
- Outdoor seasonal pool
- Golf course on site
- Golf lessons on site
- Golf driving range on site
- Golfing on site
- Hiking/biking trails on site
- Horse riding/rental on site
- Mountain biking on site
- Rafting nearby
- 24-hour business center
- Number of meeting rooms - 4
- Conference space
- Meeting rooms
- Conference space size (feet) - 6000
- Conference space size (meters) - 557
- 24-hour front desk
- Laundry facilities
- Wedding services
- Number of buildings/towers - 26
- Year Built 2003
- ATM/banking
- Designated smoking areas (fines apply)
- Picnic area
- Accessible bathroom
- In-room accessibility
- Roll-in shower
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Hypo-allergenic bedding available
- Individually decorated
- Private bathroom
- Shower only
- Designer toiletries
- Hair dryer
- Cable TV channels
- Free WiFi
- Phone
- Refrigerator
- Microwave (on request)
- Free bottled water
- Daily housekeeping
- In-room safe
- Connecting/adjoining rooms available
- Access via exterior corridors
Special features
DiningCandelilla Cafe - Overlooking the golf course, this family restaurant serves breakfast, lunch, and dinner. A children's menu is available.
On Site
- Golf course on site
- Golf lessons on site
- Golf driving range on site
- Golfing on site
- Hiking/biking trails on site
- Horse riding/rental on site
- Mountain biking on site
- Rafting nearby
Lajitas Golf Resort and Spa's small print
Also known as
- Lajitas Golf
- Lajitas Golf Resort
- Lajitas Resort
- Lajitas Golf Hotel Lajitas
- Lajitas Golf Resort & Spa Big Bend National Park
- Lajitas Golf Resort And Spa
- Lajitas Hotel
- Lajitas Resort Texas
- Lajitas Golf Resort Big Bend National Park
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Children under 17 years old are not allowed in the swimming pool or fitness facility without adult supervision.
This property does not have elevators.
Reservations are required for golf tee times and can be made by contacting the property before arrival at the number on the booking confirmation.
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Mandatory fees
Pet deposit: USD 50.00 per stay
Optional extras
Late check-out can be arranged for an extra charge of USD 75.00
Rollaway beds are available for an additional charge
Breakfast costs between USD 5 and USD 15 per person (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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Rutland man guilty of setting fires in national forestNovember 15,2013
Local man admits
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A Rutland man has pleaded guilty to starting fires on Green Mountain National Forest land.
Jack P. Dickson pleaded guilty Wednesday in U.S. District Court to three federal misdemeanor charges of setting a fire on national land without authority, leaving a fire without completely extinguishing it and damaging government property.
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U.S. Forest Service agents and the Vermont State Police fire investigation unit arrested Dickson after an investigation into a 6-acre wildfire that burned a section of woodland in Mount Holly in March 2012.MORE IN This Just InDUXBURY Harwood Union High School is preparing a life celebration for five students who were... Full StoryThe Vermont Department of Fish and Wildlife says the presence of a Canada lynx has been confirmed... Full StoryWARDSBORO Vermont State Police said Friday that Kirby Staib of Wardsboro, who was allegedly... Full Story
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Thora Birch
Born on March 11, 1982
From Los Angeles, California
Homeless to Harvard: The Liz Murray Story (2003)
Thora Birch as "Liz Murray"
Living on the streets, a teenager (Thora Birch) returns to high school, earns her diploma and gets a college scholarship.
|Emmy (Primetime) (2003)
|Outstanding Lead Actress in a Miniseries or Movie
Thora Birch as "Enid"
The story of neo-cool Enid (Thora Birch) and Rebecca (Scarlett Johansson) who, faced with graduation from high school, take a hard look at the world they wryly observe and decide what they really want. When Enid takes an interest in the offbeat Seymour (Steve Buscemi) and Rebecca focuses her attention on their mutual romantic fixation Josh (Brad Renfro), the girls' friendship is forever changed.
|Golden Globe (2001)
|Best Performance By an Actress in a Motion Picture - Comedy or Musical
Thora Birch as "Jane Burnham"
Lester Burnham (Kevin Spacey) is a gainfully employed suburban husband and father. Fed up with his boring, stagnant existence, he quits his job and decides to reinvent himself as a pot-smoking, responsibility-shirking teenager. What follows is at once cynical, hysterical, and, eventually, tragically uplifting.
|British Academy of Film & Television Arts (1999)
|Actress in a Supporting Role
|Screen Actors Guild Awards (1999)
|Outstanding Performance by a Cast in a Motion Picture


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text: Australian galleries killing it at Art Basel HK Print Email Share Tweet Email to a friend Your email Your name Friend's email Friend's name Verification (type the code in the image) Generate New Image Close Related Articles $30,000 Fellowship for a NSW Artists with Disability A new fellowship for a mid-career or established artist with disability is the first of its kind. New vision for Boyd's property Six architects have been shortlisted to deliver a new Masterplan for Boyd's iconic south coast property at Bundanon. To Gen Y, feminism is the F-word A new generation of young female artists is more influenced by the Spice Girls than Germaine Greer. Confronting animal ethics through contemporary art Have our galleries turned into menageries? Three exhibitions look at the place animals hold in contemporary art practice. Gina Fairley Vernissage bought sales and sensation to the Hong Kong art fairs, with several Oz galleries catching the eye of the Asian market. Asian collectors at Vernissage couldn't get enough of Sam Jinks, presented by Sullivan + Strumpf at Art Basel Hong Kong. Photo ArtsHub. There was a strong gathering of Australian collectors, curators and art community in Hong Kong for Vernissage and Art Week with the launch of the Asia's hottest fair, touted as the gateway to the Chinese market, Art Basel Hong Kong (ABHK) third edition in its current iteration, and its new edgy satellite, Art Central. Moving it to the new March location had paid off, said fair director Marc Spiegler, adding that 20 new galleries had joined Art Basel as a result, taking the total to 233 galleries. 'We believe this fair can only reach its full potential by taking place at a date that is optimal for the entire art world,' Spiegler told press the new dates had attracted a more diverse clientele. ADVERTISEMENT May would have been a disastrous clash with Venice Biennale draining the collector pool. And while the new dates clash with Art Dubai, which others deem equally tragic, May works well for HK both in terms of weather, the auctions and the packaging of events. Today Art Basel reported that nearly 60,000 attended the fair, just slightly less than last year which ran for an extra day. While there are six satellite fairs, the only one to be spoken of was the inaugural edition of Art Central, located a short way down the Harbour front and adding balance through its emerging platform. It's being touted by organisers as HK's 'first international standard satellite art fair' (a curious distinction), and with 30,000 visitors confirmed by its closing Monday evening, it clearly had an impact. Using a proven Miami model of architecturally designed temporary structure, it had a visual signature we've come to recognise of Etchells' fairs, with the use of plywood signage and funky pop-up restaurant and hawker food break out area defined itself superbly alongside the bigger Art Basel, remaining in sync with its emerging artist / emerging gallery platform. Photo ArtsHub It returned fair entrepreneur Tim Etchells to Hong Kong, the man (along with Sandy Angus and Will Ramsay) behind Hong Kong's first art fair ArtHK before selling it to Art Basel, and the brainchild behind Sydney Contemporary, Australia's next fair this coming September. Furthermore, the fair's co-director Maree Di Pasquale was former Melbourne Art Fair Assistant Director, and had worked on the launch of Sydney Contemporary. She is joined in the role by Eve Share Banghart. It is just another instance of the strong Australian connection to the Hong Kong fairs. Eight Australian galleries were accepted into the competitive ABHK - Jensen, Roslyn Oxley9, Anna Schwartz, Sullivan + Strumpf, Dianne Tanzer, Tolano, Murray White and Darren Knight for their first visit in the Discoveries section - while Art Central was the choice for Chalk Horse, Conny Dietzhold, M Contemporary, Martin Brown and Metro Gallery. Chair of Australia Council, Rupert Myer, and Art Advisor Bambi Blumberg were seen leading tours for Australia's top drawer collecting set over Vernissage, while Sydney-based Alexie Glass-Kantor, director of Artspace, created alleyways of quirky curiosities that punctuated the exhibition halls for ABHK's Encounters program, which one might argue has given the fair its signature this year. 'Australians are everywhere,' was the comment often repeated. Mikala Dwyer was the only Australian artist in the Encounters section, making a splash with her colourful installation. So what of the energy and sales? High voltage is one description. Jasper Knight, co-director of Chalk Horse, captured it in his comment: 'Berocca needs to sponsor an art fair!' Ursula Sullivan, of Sullivan+Strump, said of the persistent swell of viewers: 'I can't even get into my booth!' The Sydney gallery did fabulously with Sam Jinks' sculptures presenting two editions of five, one sold out and the second almost also by the start of the weekend, and several days still to go. Priced at $US155,000/AUD200,000 Untitled (Standing Pieto) (pictured top), Jinks' sculptures were photographed and highlighted by local press. His artwork had also done extremely well in Singapore for the fair earlier this year. Sam Jinks sculptures were a big draw card - this piece a sell out - at Sullivan+Strumpf; Photo ArtsHub Traffic flow increased over the weekend. Anna Schwartz, manning her booth on Sunday, was on heightened sensors protecting fragile works by Yin Xiuzhen and Callum Morton in particular. Intriguing work – despite its fragility – however remained a strong choice by both galleries; their persistent repeated return to Hong Kong had paid off. Art fairs today are hardly a walk in the park; the weekends draw huge crowds (Anna Schwartz booth pictured), which can be stressful on dealers whose primary interest always remains with the care of the artwork. The same image was mirrored at Sullivan+ Strumpf where a staff member held a permanent post as protector over Jinks' sculpture. Hiromi Tango's happy; her installation sold at Art Basel Hong Kong with Sydney dealers Sullivan+Strump; Photo ArtsHub Hiromi Tango's large installation at Sullivan+Strumpf similarly captured the interest of Hong Kongese, selling to a private collector. While Alex Seton charmed collectors with his marble sculptures, selling smaller work on the first day and reaching a crescendo placing his sculpture Durable Solutions I with an Australian collector in HK for the fair. Seton with dealer Joanna Strumpf with his sold work (which will return to Australia with a collector) at Art Basel Hong Kong; Photo ArtsHub. A spokesperson at Roslyn Oxley9 Gallery said they had sold fifty per cent of their booth by the Friday preview, the first viewing by VIP collectors, including pieces by Bill Henson and Daniel Boyd. The gallery was in sync with other big sales landed in the first hours. Sydney art advisor Mark Hughes looking at a Daniel Boyd painting in Roslyn Oxley9's well positioned booth, which sold during the previews. Photo ArtsHub. The most hyped sale of the fairs was Chris Ofili's large canvas Dead Monkey—Sex, Money and Drugs (2000) sold by David Zwirner for $US2 million within the first hour of the Friday preview opening. Clearly, it had been pre-arranged; the elephant dung work one of his largest and the artist's popularity on a high following his solo at the New Museum in New York. It was last traded at auction in 2010 for a below-estimate $US962,500. Does that say more about art fairs or the clout of a major survey? Ofili was not the most expensive work at ABHK, with Brancusi's Le Poisson (1926) at Paul Kasmin Gallery rumoured to be priced at $US3 million. Artnet reported that Zwirner also sold two Neo Rauch paintings, "Marina" (2014), for $1 million to a collector from Shanghai during the last minutes of opening day, and "Die Fremde" (2015), for $1 million to a client from mainland China.. and two Yayoi Kusama infinity net paintings, each for above $300,000. The most hyped was Chris Ofili's large canvas Dead Monkey—Sex, Money and Drugs (2000) sold by David Zwirner for $US2 million immediately with opening of Friday preview. Clearly, it had been pre-arranged; the elephant dung work one of his largest and the artist's popularity on a high following his solo at the New Museum in New York. It was last traded at auction in 2010 for a below-estimate $US962,500. Does that say more about art fairs or the clout of a major survey? Ofili was not the most expensive work at ABHK, with Brancusi's Le Poisson (1926) at Paul Kasmin Gallery rumoured to be priced at $US3 million. Artnet reported that Zwirner also sold two Neo Rauch paintings, Marina (2014), for $1 million to a collector from Shanghai during the last minutes of opening day, and Die Fremde (2015), for $1 million to a client from mainland China and two Yayoi Kusama infinity net paintings, each for above $300,000. It is quite a contrast to first timer Darren Knight, whose booth looked stunning hung with paintings by Jon Campbell, all of same dimension. It was an effective choice that made their small booth shine amongst the dervish. Knight sold over the fair, however for him, it was about the connections and conversations. Darren Knight in booth of Jon Campbell's paintings. Photo ArtsHub Knight along with Dianne Tanzer were the only among the Australian galleries to present a solo exhibition. Yhonnie Scarce's glass works and installation had a powerful impact – also fragile yet strong - telling a story of Maralinga. Born in Woomera it was great to see her work in this regional context that draws curators and collectors from across the globe. By the weekend Scarce's work was yet to be placed, but as with all art fairs it is the flow on conversations that follow that lead to opportunities. Scarce with her work This is no fantasy presented by Dianne Tanzer gallery at Art Basel Hong Kong; Photo ArtsHub Scarce, Seton, Tango and Tomescu were in Hong Kong and gave artist talks during the fair. Australians also had a strong presence in ABHK Convesations and Salon program, with Philip Kerr, co-founder of the Keir Foundation and Chairman of the Biennale of Sydney in conversation with major Asian collectors. We will bring you a wrap of that talk later this week. Charles Mereweather, Aaron Seeto, Thomas J. Berghuis, and Hong Kong-based former aussie John Batten also spoke on panels, giving weight to Australian voices. Collector and architect William Lim with Philip Keir and Alan Lau, collector and member of Tate Asia Pacific's Acquisition Committee (pictured) chatted with Anurag Khana, winner of the Forbes Young Collector 2014, at Art Basel. Talk was also about sales over at Art Central. Chalk Horse had sold five works and landed two commissions for Andre Hemer, and they were only two days in. It was a fantastic early result for the gallery that specialises in emerging artists. Knight said Art Central was a 'good size, a good fit.' Jasper Knight mentioned that their 'neighbouring booth' has sold a work priced at $1 million and a second work in a similar range, confirming that the big sales were not just reserved for the big fair. Co-founders Chalk Horse gallery James Kerr and Jasper Knight had a great fair selling well at Art Central focused on emerging artists. Photo ArtsHub. Conny Dietzschold and M.Contemporary were both positioned well and had a constant stream of booth-dwellers, while Martin Browne was embedded deeper into the temporary halls and lacked approachability. Barry Keldoulis, Director of Art Fairs Australia with Michelle Paterson of M.Contemporary Word on the ground was that Art Central was worth the short taxi ride, and one Malaysian dealer even mentioned that they would have preferred to be at the smaller edgier fair. Richard Koh owner of Richard Koh Fine Art from Kuala Lumpur said: 'We've seen an intelligent, sophisticated crowd come through the fair. We've sold almost all of our pieces and even brought more works over to the fair to cater to the demand. Art Central has exceeded our expectations and we are already looking forward to next year.' It was reiterated by several dealers including, Fred Scholle of Gallery Du Monde, who said: 'Art Central was far beyond what we expected. We sold out of all Li Hao's works on the second day and brought in four additional works which also sold out immediately. We made the correct decision to go with Art Central.' More generally, works by contemporary Chinese artists sold fast and, to extend that like-attracts-like mentality, the majority of Australian works sold went to Australian collectors. Swiss dealer Dominique Perregaux of the Hong Kong based Art Statements gallery at Art Central presented two large Dale Frank paintings, the larger priced at $AUD78,000. 'Where are the Australian collectors?' said Perregaux, adding that when 'you are selling at that price range' you are relying on that knowledge of the artist. Dealer Dominique Perregaux with Dale Frank's work at Art Central. There were other non-Australian galleries hoping to capitalize on the strong Australian contingent. Malaysian artist Anurendra Jegadeva, who has just returned to live in Melbourne (where he'd lived previously) presented the new installation Yesterday in a padded room with Malaysian powerhouse gallery, Weiling Gallery, its principal Weiling Lim also had studied as an artist in Australia. Like many Southeast Asian works of this scale and quality, dealers turn to the region and institutions such as the Singapore Art Museum, the Gallery of Modern Art in Brisbane and Art Gallery of New South Wales, to collect these important historical works to the region. Weiling Lim with Director of Asia Adeleine Ooi, who was recently in Australia, and Anu Jegadeva. Photo ArtsHub. ABHK reported today in their wrapping statement that Curators and Directors supported the fair well: Aaron Seeto of 4A Centre for Contemporary Asian Art; Michael Brand and Suhanya Raffel of AGNSW, Nick Mitzevich of Art Gallery of South Australia, Ian Potter Museum of Art; joining international directors from Thomas Berghuis of Solomon R. Guggenheim New York; Hans Ulrich Obrist of Serpentine Gallery London; Sheikha Hoor Al Qasimi of Sharjah Art Foundation and curator of UAE Venice Pavilion; Lee Sook-Kyung from Tate Research Centre; Gregor Muir of Institute of Contemporary Art London; Phillip Tinari of Ullens Centre for Contemporary Art Beijing; Doryun Chong M+ Hong Kong, MoMA New York; MoMA PS1 and the list continues. One might hope they were shopping - or at very least was pointing out "desirables" to patrons no doubt in tow. If for no other reason, just to be in their eye underscores the advantage of our Australian galleries who headed to Hong Kong. Regardless which fair one favoured, the spirit of the fairs had not been dampened by Hong Kong's recent political troubles; The Occupy Central protest camp had only been 'officially dispersed' mid-December and the gathering of Filipinas on maids-day-off, clustered between the urban trajectory between the two fairs was a reminder of the disparity of wealth in Hong Kong. It is a complex geographical space. The one country-two-system scenario does cause tensions, and for the first time Hong Kong has event witnessed protest and street art, most visible its Umbrella Movement. Hong Kong is rapidly changing. It was handed back to China in 1997. The city has 7 million residents and it is investing heavily in its cultural identity and the educational aspect of the fair has become a priority. And of the 233 galleries in attendance, 26 are based in Hong Kong. It is an interesting new development. The dates have been released for next year so plan now. Don't rush it. This is a city to soak in and observe as it redefines itself through art. Dates for forward editions of the Hong Kong Art Fair were released so plan now. 2016: Preview (invitation) Tuesday evening 22 March and Wednesday 23 March, with public viewings 24-26 March. 2017: Preview (invitation) Tuesday evening 21 March and Wednesday 22 March, with public viewings 23-25 March. First published on Sunday 15 March, 2015 About the author Gina Fairley covers the Visual Arts nationally for ArtsHub. Based in Sydney you can follow her on Twitter @ginafairley and Instagram at fairleygina. Share Tweet Print Email


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News on Cuyahoga County government reform and transition
Category: Metro RSS
1 | 2
District 9 mirrors Cuyahoga County in all categories except one: race
By James F. McCarty, The Plain Dealer
August 01, 2010, 7:00AM
The district is a study in contrasts: the stone mansions of Shaker Heights, boarded-up cottages in Cleveland's Ward 4 and Ward 1, to the illuminated glow of the Bedford Auto Mile, to the eclectic neon of Shaker Square's sidewalk cafes, chrome-and-glass buildings in Highland Hills and the almost-deserted shell of the North Randall Mall. Full story »
Cuyahoga County scales down airport expansion plans
By Laura Johnston, Northeast Ohio Media Group
July 28, 2010, 6:00PM
Instead of a controversial plan to reroute Bishop and Richmond roads as part of a 900-foot runway extension in Richmond Heights, county commissioners approved a 400-foot add-on that leaves the roads alone. Full story »
Cuyahoga County executive candidate Matt Dolan branches out from family tree, touts moderate views
By Henry J. Gomez, Northeast Ohio Media Group
July 25, 2010, 12:00PM
Dolan's pragmatism as a Republican state legislator was respected on both sides of the aisle. Many believe it will be an asset if he's elected this fall.Yet for all Dolan has done to carve out his own identity, he is still Larry Dolan's son. Full story »
Cuyahoga County Council District 8 voters have high hopes for new government
By Sandra Livingston, The Plain Dealer
July 25, 2010, 10:00AM
Cuyahoga County Council District 8 is a microcosm of the region's assets and troubles. Full story »
Cuyahoga County executive candidate Terri Hamilton Brown known as no-nonsense leader
By Henry J. Gomez, Northeast Ohio Media Group
July 18, 2010, 9:00AM
Many familiar with her work at organizations such as CMHA describe her as a sharp but sometimes short-tempered leader. Maybe that's why politics is not her comfort zone. Full story »
Republicans have one of their best shots at a Cuyahoga County Council seat in District 6
By Evelyn Theiss, The Plain Dealer
July 18, 2010, 8:01AM
Primary races in Cuyahoga County's wealthiest council district attract six Republicans and three Democratics. Full story »
Optimism and persistence fuel Victor Voinovich's first campaign for public office
By Henry J. Gomez, Northeast Ohio Media Group
July 11, 2010, 7:02AM
Voinovich will head to the GOP's Sept. 7 primary as an underdog against Matt Dolan, a former state representative whose father owns the Cleveland Indians. Also in the race is Paul Casey, a small business owner and high school wrestling coach from North Royalton. Full story »
Economic development drives Cuyahoga County Council's District 5 race
By Tom Feran, The Plain Dealer
July 11, 2010, 7:01AM
All roads lead to economic issues among the four primary candidates for Cuyahoga County Council's District 5 seat, encompassing Berea, Middleburg Heights, North Royalton, Olmsted Falls and Strongsville in the county's southwest corner. Full story »
Cuyahoga County District 4: Voters seek improvements in ethics, education
By Liz Navratil, The Plain Dealer
July 11, 2010, 7:00AM
In Parma and surrounding communities, voters say they're looking for county council candidates who have a strong sense of ethics and who will improve education. But County Council members have little control over the latter. Full story »
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Cuyahoga County District 3: Candidates look to allay safety concerns
By Karen Farkas, The Plain Dealer
July 04, 2010, 8:18AM
Residents of Cuyahoga County's new council District 3 want their new representative to help make their neighborhoods safer.Safety, economic development and more public transit are the major issues cited in the new Cuyahoga County Council District 3, which comprises the city's West Side Wards 13, 14, 15, 16 and 17. Full story »
Problem-solver or opportunist? Either way, ambition drives Cuyahoga County executive hopeful Ed FitzGerald
By Henry J. Gomez, Northeast Ohio Media Group
July 04, 2010, 12:00AM
One thing on which his allies and adversaries is agree is that FitzGerald, the Democratic Lakewood mayor, is a political climber, someone constantly calculating his next move. Supporters say it's a virtue, critics aren't so sure. Full story »
Cuyahoga County Council District 1 voters say key issues are honesty, accountability
By Patrick O'Donnell, The Plain Dealer
June 27, 2010, 12:00PM
Residents of this district are still sorting out just what the county council is supposed to do or what they want from the person they elect to represent them. It's an early step in the overhaul of county government that voters countywide passed last November. Full story »
1 | 2
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- PolitiFact Ohio has compiled promises that Ed FitzGerald made during the 2010 campaign and is tracking their progress.
Post your commentsTalk Cuyahoga County government in our Ohio Politics Forum