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How A Person Should Deal With Being Hurt On Account Of Neglect
An individual who is injured as a result of neglect of a different man or woman or even a business is typically entitled to compensation for their particular injuries. The compensation will usually be compensated by an insurer, but that does not mean it is easy for a person to get the compensation they require. Generally, someone may need to employ a lawyer to be able to obtain the aid they need in order to make certain they receive an appropriate settlement. By doing this, all of the bills coming from the incident will be taken care of by the responsible person.
The individual will desire to choose a legal professional who's experienced with circumstances like theirs. If someone is hurt when working, as an example, they'll desire to work with a
workers compensation benefits
. These legal professionals are aware of the process a person needs to go through to produce a workers compensation claim and thus will be able to help the man or woman file the first claim or perhaps appeal a decision that's recently been made for their own situation. In case the individual is in a motor vehicle accident, they are going to desire to hire a car accident attorney who knows just how to supply the needed facts in order to show the injured person was a victim in the vehicle accident and thus is entitled to compensation for their particular injuries.
The insurance provider for the individual or even business who's liable will almost certainly offer the smallest claim total feasible. Instead of accepting a settlement that will be way too small in order to cover all the expenses from the mishap, a person can speak to a legal professional. Their particular lawyer can work hard to be able to establish the proper total for a settlement as well as show the person must receive a settlement for their injuries. In this way, they can make sure each of the
are addressed by the party who is liable.


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Ex-Cop Arrested After Allegedly Posing as Inspector, Getting Free Nude Massage in Orange County
Massage inspector? I don't think so.
Another case of a Bad Lieutenant? Orange County Sheriff's officials say an ex-cop from suburban Chicago allegedly posed as an officer in an effort to get a nude massage.
Unfortunately for him, it seems, not only did this particular massage parlor not do the "massage my front" service he allegedly asked for while nude, but the suspicious manager called authorities while the in flagrante delicto man got at least part of the free nude (back) rub authorities say he asked for.
He must have been really tense, because officials say he even asked for $200 in cash on the way out. Alas ...
... as 47-year-old suspect Edward La Porte exited, a Lake Forrest official was arriving at the local business to ask what his inspection was all about, according to sheriff's spokesman Jim Amormino.
La Porte, who had a clipboard, gun and badge in his ruse to do an inspection, get a free massage, and maybe grab some cash -- according allegations -- apparently said he was from the state and didn't have cooperate before he took off, Amormino said.
Bad Lieutenant would have totally gone for a free nude massage, we thinks.
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The Lake Forrest official got a partial plate number for the suspect's car, however, and soon deputies were at La Porte's Mission Viejo home, where they say they found the gun and badge described by the massage manager.
This all went down on Monday, and La Porte was arrested (but we're not clear exactly what charges authorities are recommending). Amormino said deputies are looking into the possibility he could have allegedly conducted other "inspections" at area massage parlors.
Amormino says the alleged massage-o-phile works at a security company in Yorba Linda.
This particular spot in Lake Forrest, by the way, is called Golden Spa.
Golden, maybe, but for this ex-cop, it doesn't appear to have given him any kind of happy ending.
-With reporting from City News Service. Got news? Email us. Follow us on Twitter, too: @dennisjromero.
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SilverStone Grandia Series GD06 HTPC Chassis Review
The Packaging
SilverStone's Grandia GD06 ships in black and grey packaging and on this side there is a clear image of the chassis included within. Both in the listed features and in the line under the name, you can see this positive pressure chassis will support most needs.
In nine languages, the special features contained in the GD06 get listed on this side along with an image of the rear of the chassis at the bottom.
This side matches the first image we looked at, but here I will address the blue hexagon that shows this is a SilverStone SFF chassis and that it seems there is a sticker missing from where the white outline would infer one is supposed to be placed.
If FedEx hadn't blocked this side with shipping labels you would be able to read the introduction form SilverStone about the GD06 and see the specifications list below it. The sticker I thought was missing is oddly placed on this side and is blocking most of the image of the front of the GD06 pictured on this last panel.
A plastic liner keeps vibrations and light abrasions in transit from marring the paint finish or the aluminum face. To keep the GD06 centered in the box, the use of thick Styrofoam end caps support the chassis and in combination, the GD06 I received is in perfect condition.
PRICING: You can find products similar to this one for sale below.
United States: Find other tech and computer products like this over at Amazon's website.
United Kingdom: Find other tech and computer products like this over at Amazon UK's website.
Canada: Find other tech and computer products like this over at Amazon Canada's website.
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text:
Criminals to be issued with flat pack prisons
'Every prisoner will be told to stay at home and assemble their own cell.' [read...]
'Every prisoner will be told to stay at home and assemble their own cell.' [read...]
Government plans to reform SAS recruitment procedure have run into a hail of criticism. It is understood that applicants will be asked to travel through the channel tunnel in under 48 hours, and buy and assemble an entire IKEA kitchen without either also buying a pack of tealights, [read...]
Travelling light, Fiennes will sustain himself on locally-sourced balls of meat similar to beef. [read...]
After years of renown as the Mecca of marital discord, IKEA has finally succumbed to popular demand and produced the first flat-pack divorce. [read...]
'Can be put together 'in under an hour' by grieving relatives' [read...]


text: Valve Names new xbox harbingerwolf next random Comment Top NextComment What in the name of actual derp just went on here? next Tags: tags used incorr e the new r-( hex: seen, have e agreed wen a name fer the third Keck? ... +1904 Views: 69658 Submitted: 05/21/2013 Share On Facebook


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Call us now for a free consultation and quote specific to your events needs (480) 420-4040
Our sister company Portable Pubs
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Quality ingredients used to prepare everything on your menu from scratch in our commercial kitchen.
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As an Italian chef, it is of the utmost importance to me that everything we use to prepare your meal is made from fresh, quality ingredients whether it be some of the finest imports, or locally sourced from Arizona farms as many dishes on our menu are. Furthermore, all of our dishes, sauces, dressings, and most breads are made from scratch by myself and my team of classically trained culinary artists using a wide range of regional techniques. Read more....
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This collection of worksheets will help you teach your child their basic colors. We have one worksheet for each basic color and children are asked to circle all the images on a page that are the specific color for that page. These printables are perfect preschool color worksheets.
This set of learning colors worksheets is perfect for your preschool age children. They will be able to practice all their basic colors. Children will learn to trace and write the word for each basic color. They are also asked to draw a picture of something that is each color. We have one worksheet for each color.
Help kids learn about primary and secondary colors, the color wheel and warm and cool colors with this set of worksheets.
This collection of color worksheets has kids matching things that are the same colors as well as matching the colors to their names in some worksheets.
These worksheets are perfect for kids to practice the basic preschool shapes and colors in one fun activity! Kids are asked to color the specific shapes specific colors which helps them learn both at the same time.
One of the best ways for kids to learn their colors is simply by coloring. Coloring has always been a favorite with children and we've got tons of free printable coloring pages from a ton of different categories on our sister site - AllKidsNetwork.com - so check them out!
We're always adding new worksheets and crafts.
Vist our parent site, All Kids Network, for more resources for parents, teachers and anyone who works with children.


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A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: The GRACE Genetics Study
Aims Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS).
Methods and results A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00–2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99–2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00–2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03–1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method.
Conclusion In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS.
- Chromosome 9p21
- Rs1333049
- Genetics
- Acute coronary syndrome
- Myocardial infarction
- Plaque rupture
See page 1038 for the editorial comment on this article (doi:10.1093/eurheartj/ehq054)
Coronary artery disease (CAD) is a complex cardiovascular disorder caused by the interaction of environmental factors and hereditary predisposition.1,2 Recently, the unbiased identification of genetic variations underlying cardiovascular disease has become a fruitful enterprise, with at least four genome-wide association studies identifying chromosome 9p21 as a major locus for risk of CAD or myocardial infarction (MI).3–6 Strikingly, the pathophysiologic effects of the 9p21 locus are not restricted to the coronary vasculature, since genetic variants in this locus have also been linked to abdominal aortic aneurysm, peripheral artery disease, and stroke.7 In addition, the 9p21 locus has been associated with prevalence of atherosclerotic plaque in carotid arteries from healthy individuals, suggesting that the 9p21 locus promotes atherosclerosis.8
Unresolved questions regarding the role of chromosome 9p21 in CAD still remain. Little is known, for instance, about the effect of 9p21 in an unbiased population of acute coronary syndrome (ACS) patients presenting to hospital. Indeed, most CAD/MI studies so far were performed in patients with a familial predisposition (e.g. patients with at least one affected sibling) or in patients presenting at an early age.3,4,9,10 Furthermore, none of these studies focused on the full spectrum of ACS, including the ST-elevation MI (STEMI), non-STEMI, and unstable angina (UA) subtypes, which differ from each other in the degree of thrombus formation.11 Importantly, it is also unknown whether the 9p21 locus confers a risk for recurrent MI or cardiac death following an index ACS. If genetic factors predispose to adverse outcome, this may influence clinical management. Acute coronary syndrome patients are most vulnerable to recurrent and lethal cardiovascular complications during the first 6 months after the primary event, but identification of those most at risk is elusive, when based on clinical phenotypes and presentation characteristics. Improved risk prediction using a combination of phenotypic characteristics and genetic testing could therefore guide patient triage and improve acute and longer-term patient care.12
In the present study, we used the Global Registry of Acute Coronary Events (GRACE) program, which is a large, prospective, multinational observational study of patients hospitalized with ACS. The GRACE Genetics Study employs standardized criteria for inclusion and outcome events across the geographically distinct populations in the UK, Belgium, and Poland. After confirming that the 9p21 locus associated with primary MI in the GRACE Genetics Study, we tested whether this association was independent from the ACS subtype. We next assessed whether the 9p21 locus correlates with recurrent MI and the combined endpoint consisting of recurrent MI or cardiac death.
Study populations and phenotype descriptions
Grace genetics study
The GRACE registry is a large scale, multinational, prospective observational study of the spectrum of patients with an ACS hospitalized between July 1999 and December 2007. The GRACE Genetics Study consists of the 3473 patients from whom DNA was collected by the eight participating centres in three countries (UK, Belgium, and Poland) between May 2001 and June 2007. Collected blood samples were transferred to the core laboratory (The Queens Medical Research Institute, Edinburgh, UK), where DNA was extracted and stored at −80°C.
Full details of the methods used in the GRACE registry have been published previously.13 Briefly, patients were eligible if they were admitted to participating hospitals with a clinical diagnosis of ACS and at least one of the following features: electrocardiographic changes consistent with ACS, increases in serum biochemical markers of cardiac necrosis [positive troponins, creatinine phosphokinase (CPK), or creatine kinase MB (CK-MB) fraction above two times the upper limit of normal (ULN)], documented CAD [i.e. history of MI; congestive heart failure believed to be due to ischaemia or resuscitated sudden death; history of/or new positive stress test or angina, with or without imaging; prior or new cardiac catheterization documenting artery disease, percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG)], or both. The presentation of the patients with ACS was not the consequence of trauma, surgery, or other significant co-morbidity (for example anaemia). To ensure enrolment of an unselected ACS population, sites recruited the first 10–20 consecutive eligible patients each month. Regular audits were performed at all participating hospitals to confirm conformance to eligibility criteria and correct interpretation of data in the case report form. Trained study coordinators collected data using standardized case report forms. Demographic characteristics, medical history, presenting symptoms, duration of pre-hospital delay, biochemical and electrocardiographic findings, treatment practices, and outcomes were collected. All cases were assigned to one of the following categories using predefined criteria: (i) STEMI (including left bundle-branch block), (ii) non-STEMI, (iii) UA, and (iv) other cardiac or (v) non-cardiac diagnoses.13 All patients were prospectively followed-up by trained study coordinators at 6 months following admission. Methods of follow-up involved one or more of the following: phone call to patient, hospital visit, phone call to patient's general physician, and/or use of hospital records. All participating hospitals were subject to a rigorous on-site 3 years audit cycle, which involved source verification of randomly selected cases and validation of outcome events. Outcome events (including recurrent MI) were prospectively defined using standard definitions for the entire study, independent of local interpretations.
The primary endpoint for this study was recurrent MI within the first 6 months following the day of hospital admission. A second endpoint consisted of recurrent MI or cardiac death. Non-cardiac death was deliberately excluded as an outcome event since there may be multiple different mechanisms of death without implicating a recurrent myocardial ischaemia or infarction. In-hospital recurrent infarction was confirmed by ECG changes or elevation of cardiac markers, as described previously.12 In patients with acute MI, biomarker criteria for in-hospital recurrent infarction were: (i) re-elevation of the troponin above ULN and increase by at least 20% over the previous value or CK-MB above the ULN and increased by at least 50% over the previous value. (ii) If CK-MB or troponin were not available, CPK had to be either >2 × ULN and increased by 25% over the previous value, or >1.5 × ULN and increased by at least 50% over the previous value. (iii) Following PCI or CABG, CK-MB (or CPK) elevation had to be >3× or >5 × ULN, respectively, and increased by at least 50% over the previous value. (iv) Following CABG, recurrent MI required biomarker and ECG criteria consistent with MI.13
Local hospital ethics committees approved the GRACE Genetics Study. All patients provided written informed consent for follow-up contact and DNA sampling at enrolment, in accordance with the declaration of Helsinki.
Asklepios study cohort
A total of 2524 participants (1301 women) of 35–55 years, free from overt cardiovascular disease at study initiation, were randomly sampled from the twinned Belgian communities of Erpe-Mere and Nieuwerkerken, Belgium, between October 2002 and October 2004. Exclusion criteria were: (i) clinical presence of atherosclerosis or atherothrombosis (symptomatic or haemodynamically significant stenosis, prior atherothrombotic event, and revascularization); (ii) major concomitant illness; (iii) diabetes mellitus type 1 and type 2 if proven macro-vasculopathy or end-stage renal disease; (iv) conditions precluding accurate haemodynamic assessment (atrial fibrillation, pregnancy); (v) inability to provide informed consent.14 Rs1333049 genotypes were available for 2467 participants (97.7%).
Wellcome Trust Case Control Consortium (WTCCC) Controls
A total of 3004 controls from the Wellcome Trust Case Control Consortium (WTCCC) (1504 individuals from the 1958 British Birth Cohort sampled between 2002 and 2004 and 1500 individuals from the UK Blood Service Group) were used as control population for the GRACE patients from the UK.3 Genotypic data for rs1333049 were obtained for 2936 participants (97.7%) from the European Genotype Archive (http://www.ebi.ac.uk/ega).
Genotyping of SNPs in the 9p21 locus
The 9p21 locus that is linked with CAD encompasses two linkage disequilibrium (LD) blocks. Based on r2 calculations between SNPs in both LD blocks, it was demonstrated that rs1333049 is the most representative SNP for the first block. The association signal in the second block can be most consistently captured by three SNPs, i.e. rs7044859, rs1292136, and rs7865618.4,9 We therefore genotyped these four SNPs on the 9p21 locus in a blinded manner using iPLEX technology on a MassARRAY Compact Analyser (Sequenom Inc., CA, USA), as described previously.15 However, since the first LD block (represented by rs1333049) is most prominently linked to CAD, we focused most of the analysis on rs1333049.9 The WTCCC controls were previously genotyped using the Affymetrix platform (Affymetrix Inc., CA, USA).3
Statistical analysis
Data are summarized as frequencies and percentages for categorical variables. Continuous variables are presented as medians with 25th and 75th percentiles. Hardy–Weinberg equilibrium of the genotypes was assessed using Pearson's χ2-test. For the case–control studies, the difference in genotype frequencies was calculated using Pearson's χ2-test. Meta-analysis was performed with the Mantel–Haenszel and the DerSimonian and Laird method.16 Heterogeneity across the study populations was calculated using the χ2-based Cochran Q statistic.17 Lambda statistics was used to calculate the genetic model of inheritance, as previously published.18
For most variables, less than 1% of the data was missing. However, for a number of variables, the percentage of missing values was higher, including serum total cholesterol (12.6%), creatinine (3.6%), systolic blood pressure (2.9%), pulse (3.3%), initial cardiac enzymes (4.0%), Killip class (2.3%), and the use of thrombolytics (2.3%). Missing values were sampled using a multiple imputation technique based on the Markov chain Monte Carlo method (the SAS procedure MI) with seven imputation data sets. Results were combined using the SAS procedure MIANALYSE. In 38.2% of the patients with a recurrent MI, the time of the recurrence was missing since it was not collected in initial case report forms used before July 2002. Missing event times were therefore imputed by a random draw from observed event times. Incident recurrent MI analysis was performed by Cox proportional hazard model using the SAS procedure PHREG, while considering clinical variables known to be associated with recurrent MI as covariates.12,19 These included: age, gender, history of angina, prior MI, diabetes, current smoking status, systolic blood pressure, heart rate, total cholesterol, initial serum creatinine level, elevated initial cardiac enzymes, ST segment depression, Killip class, PCI, CABG, thrombolytics as well as participating country. The cumulative incidence function (CIF) was calculated and plotted for recurrent MI, assuming competing risk of death. For recurrent MI or death, the Kaplan–Meier curve was calculated, using the SAS procedure LIFETEST. Consistency with non-imputed data was confirmed by repeating the analysis with non-imputed data.
Comparison of the GRACE score for improvement in reclassification with and without rs1333049 was done by the Integrated Discrimination Improvement method, which compares the average difference in correctly predicting the risk for patients who have a recurrent MI with those who do not.20
All P-values were two-tailed and <0.05 was considered statistically significant. This was a hypothesis-generating and exploratory study, in which the primary endpoint of interest was the association between rs1333049 and recurrent MI or cardiac death. Therefore, no adjustments were made to the significance level to account for multiple testing. Statistical analyses were performed using the SPSS software version 17.0 (SPSS Inc., IL, USA) and the SAS software version 9.1 (SAS Institute Inc., NC, USA).
Grace genetics study
Overall, 3473 patients were enrolled in the GRACE Genetics Study. Patients with no diagnosis, a non-cardiac diagnosis, or with no ACS at the time of hospital discharge (16, 111, and 102 patients, respectively) were excluded. For the remaining 3247 patients with confirmed ACS, follow-up status 24 h after initial presentation and at a median of 6 months was available for 2980 (91.8%) ACS patients. Of these 2980 patients, genotypes for the rs1333049 variation were available in 2942 patients (98.7%). The genotyping success rate for rs1333049 was ≥98.7%, and 95.2% for rs7044859, 98.9% for rs496892, and 97.3% for rs7865618. Fifty-five samples were genotyped twice with an average concordance of ≥99.8%. No deviation from Hardy–Weinberg equilibrium was seen in any of the cohorts (P > 0.05).
The median follow-up in these 2942 patients was 195 days [interquartile range (IQR) 185–212] following admission, with a recurrent MI occurring in 170 patients (5.8%) and a recurrent MI or cardiac death in 205 patients (7.0%). The median time to recurrence was 12 days (IQR 4–57) for recurrent MI and 29 days (IQR 4–121) for recurrent MI or cardiac death. In Table 1, demographic characteristics, medical history, and presenting clinical features are shown for all patients with a primary ACS. Approximately 28.7% of the primary ACS patients presented with an ST-segment elevation or a left bundle branch block, 70.5% had positive cardiac biomarkers of necrosis, 47.5% had a PCI, and 13.2% received thrombolytics. Consistent with previous studies,21,22 patients with recurrent MI were older, more likely to have prior history of vascular disease, exhibited a higher GRACE risk score for an endpoint predicting death or recurrent MI, and were more likely to have three-vessel disease, as calculated by the number of coronary vessels with >50% stenosis (Table 1). In addition, patients with a non-STEMI and those treated with thrombolytics were more prone to recurrent MI.
|No recurrent MI
|Recurrent MI
|No. of patients (%)
|2772 (94.2%)
|170 (5.8%)
|Men, n (%)
|1984 (67.9%)
|1869 (67.9%)
|115 (68.9%)
|1.05 (0.75–1.46)
|Age, median (25th–75th percentiles), year
|65 (55–73)
|65 (55–73)
|70 (61–79)
|1.04 (1.03–1.06)
|BMI, median (25th–75th percentiles), kg/m2
|27.04 (24.37–30.10)
|27.04 (24.38–30.10)
|27.04 (24.22–29.91)
|1.00 (0.99–1.00)
|Medical History, n (%)
|1628 (55.5%)
|1515 (54.8%)
|113 (66.5%)
|1.64 (1.18–2.27)
|500 (17.0%)
|458 (16.6%)
|42 (24.7%)
|1.65 (1.15–2.38)
|Prior MI
|799 (27.3%)
|729 (26.4%)
|70 (41.2%)
|1.95 (1.42–2.68)
|Congestive heart failure
|200 (6.8%)
|179 (6.5%)
|21 (12.4%)
|2.05 (1.26–3.31)
|Stroke or transient ischaemic attack
|173 (5.9%)
|164 (5.8%)
|12 (7.1%)
|1.23 (0.67–2.26)
|Prior PCI
|408 (13.9%)
|381 (13.8%)
|27 (15.9%)
|1.18 (0.77–1.81)
|Prior CABG
|240 (8.2%)
|223 (8.1%)
|17 (10%)
|1.27 (0.75–2.13)
|Peripheral arterial disease
|217 (7.4%)
|190 (6.9%)
|27 (16.0%)
|2.57 (1.66–3.98)
|1587 (54.2%)
|1491 (54.0%)
|96 (56.5%)
|1.10 (0.81–1.51)
|1192 (40.7%)
|1121 (40.6%)
|71 (41.8%)
|1.05 (0.76–1.43)
|Combined history of atherosclerosis
|1853 (63.2%)
|1722 (62.3%)
|131 (77.1%)
|2.03 (1.41–2.93)
|Family history of coronary artery disease
|581 (26.1%)
|559 (26.3%)
|22 (22.4%)
|0.81 (0.50–1.31)
|Smoking status, n (%)
|874 (30.3%)
|831 (30.6%)
|43 (25.4%)
|0.77 (0.54–1.10)
|786 (27.2%)
|739 (27.2%)
|47 (27.8%)
|1.03 (0.73–1.46)
|Presenting characteristics
|Positive initial enzymes, n (%)
|1991 (70.5%)
|1860 (69.9%)
|131 (79.1%)
|1.71 (1.15–2.52)
|ST elevation or LBBB, n (%)
|843 (28.7%)
|793 (28.6%)
|50 (29.4%)
|1.04 (0.74–1.46)
|ST depression or T wave inversion, n (%)
|1032 (35.1%)
|949 (34.2%)
|83 (48.8%)
|1.83 (1.34–2.50)
|Systolic blood pressure, median (25th–75th percentiles), mmHg
|140 (120–160)
|140 (120–159)
|140 (120–160)
|1.00 (0.99–1.01)
|Diastolic blood pressure, median (25th–75th percentiles), mmHg
|80 (70–90)
|80 (70–90)
|80 (70–90)
|1.00 (0.99–1.01)
|Pulse (25th–75th percentiles), b.p.m.
|75 (64–87)
|75 (64–86)
|80 (65–96)
|1.01 (1.00–1.02)
|Killip class, n (%)
|2271 (79.0%)
|2163 (79.9%)
|108 (65.1%)
|524 (18.2%)
|476 (17.6%)
|48 (28.9%)
|2.02 (1.42–2.88)
|68 (2.4%)
|58 (2.1%)
|10 (6.0%)
|3.45 (1.72–6.94)
|11 (0.4%)
|11 (0.4%)
|0 (0%)
|Creatinine, median (25th–75th percentiles), mg/dL
|1.04 (0.90–1.22)
|1.04 (0.90–1.22)
|1.13 (0.96–1.39)
|1.22 (1.03–1.45)
|Serum cholesterol, median (25th–75th percentiles), mg/dL
|194 (166–228)
|194 (166–229)
|184 (159–213)
|0.99 (0.99–1.00)
|GRACE risk score
|Probability of in-hospital death or MI, median (25th–75th percentiles), %
|11 (8–17)
|11 (8–17)
|14 (9–19)
|1.04 (1.02–1.06)
|Probability of death or MI 6 months after discharge, median (25th–75th percentiles), %
|4 (3–8)
|4 (3–8)
|7.5 (4–15)
|1.05 (1.03–1.07)
|STEMI, n (%)
|768 (27.2%)
|724 (27.2%)
|44 (26.8%)
|0.99 (0.69–1.41)
|Non-STEMI, n (%)
|1223 (43.3%)
|1136 (42.7%)
|87 (53.0%)
|1.51 (1.11–2.06)
|UA, n (%)
|833 (29.5%)
|800 (30.1%)
|33 (20.1%)
|0.59 (0.40–0.88)
|Cardiac catheterization, n (%)
|1926 (65.8%)
|1817 (65.9%)
|109 (64.5%)
|0.94 (0.60–1.30)
|Three-vessel disease (>50% stenosis), n (%)
|445 (23.1%)
|400 (22.0%)
|45 (41.3%)
|2.35 (1.58–3.51)
|Left main (>50% stenosis), n (%)
|138 (7.2%)
|127 (7.0%)
|11 (10.1%)
|0.70 (0.35–1.28)
|PCI, n (%)
|1397 (47.5%)
|1325 (47.9%)
|72 (42.4%)
|0.80 (0.58–1.09)
|Thrombolytics, n (%)
|380 (13.2%)
|342 (12.6%)
|38 (22.8%)
|2.04 (1.39–2.98)
|CABG, n (%)
|111 (3.8%)
|103 (3.7%)
|8 (4.7%)
|1.28 (0.61–2.67)
Data were analysed by logistic regression. Combined history of atherosclerosis comprehends medical history of angina, prior MI, stroke or transient ischaemic attack, prior PCI, CABG, or peripheral arterial disease. A 50% stenosis cut-off was used to determine presence or absence of CAD, instead of a 70% stenosis cut-off, which is used to denominate clinically significant stenosis.
CABG, coronary artery bypass graft; CI, confidence interval; LBBB, left bundle branch block; MI, myocardial infarction; N/A, non-applicable; OR, odds ratio; PCI, percutaneous coronary intervention; STEMI, ST-segment elevated myocardial infarction; UA, unstable angina.
9p21 increases the risk for acute coronary syndrome in a hospital-based population
In order to validate the association of rs1333049 with CAD in the GRACE Genetics Study, we first assessed whether the rs1333049 variation was associated with ACS and therefore performed a case–control association study for the UK and Belgian GRACE patients. To this extent, we used population-based DNA cohorts from the two countries: 2936 participants from the WTCCC study3 and 2467 individuals from the Asklepios Study.14 GRACE patients from Poland were not used because no population-based control cohort with existing genotypic information for rs1333049 was available. In the UK and Belgian sub-studies, the at-risk C allele of rs1333049 was uniformly associated with ACS with respective odds ratios of 1.25 (CI = 1.13–1.39; P = 1.0 × 10−5) and 1.15 (CI = 1.02–1.29; P = 0.024), and a pooled OR of 1.21 (CI = 1.10–1.32; P = 2.4 × 10−6 under a fixed effects model, P = 4.6 × 10−5 under a random effects model; P for heterogeneity = 0.189) for both studies. Genotypic analysis showed that the pooled risk of carrying a single C allele was 1.20 and the risk of carrying two at-risk C alleles was 1.45 (see Supplementary material online, Table S1). Overall, the observed risk effects were in accordance with those observed in previous studies3,4,9 demonstrating that the rs1333049 variant is also a risk factor for unselected patients with ACS seen in daily practice.
Association of 9p21 with clinical subtypes of acute coronary syndrome
Having confirmed that rs1333049 is a risk factor for ACS also in the GRACE Genetics Study, we next assessed whether the rs1333049 acts independently from known clinical risk factors for cardiovascular disease to increase susceptibility for ACS. As shown in Table 2, no significant differences for any of the demographic or phenotypic risk factors were seen. Remarkably, rs1333049 genotypes were also similarly distributed among the different ACS subtypes (STEMI, non-STEMI, and UA), thus indicating that the full spectrum of ACS, rather than a particular subtype, was associated with rs1333049 (Table 2).
|rs1333049 Genotype
|No. of patients (%)
|726 (24.7%)
|1460 (49.6%)
|756 (25.7%)
|Men, n (%)
|1984 (67.9%)
|485 (67.4%)
|992 (68.4%)
|507 (67.6%)
|Age, median (25th–75th percentiles), year
|65 (55–73)
|65 (56–73)
|65 (55–73)
|66 (56–74)
|BMI, median (25th–75th percentiles), kg/m2
|27.0 (24.4–30.1)
|26.8 (24.2–30.1)
|27.1 (24.5–30.1)
|27.1 (24.3–30.1)
|Medical history, n (%)
|1628 (55.5%)
|390 (53.9%)
|797 (54.7%)
|441 (58.5%)
|500 (17.0%)
|122 (16.8%)
|248 (17.0%)
|130 (17.3%)
|Prior MI
|799 (27.3%)
|195 (26.2%)
|381 (26.2%)
|223 (29.5%)
|Congestive heart failure
|200 (6.8%)
|53 (7.3%)
|101 (7.0%)
|46 (6.1%)
|Stroke or transient ischaemic attack
|173 (5.9%)
|43 (5.9%)
|82 (5.6%)
|48 (6.4%)
|Prior PCI
|408 (13.9%)
|99 (13.7%)
|204 (14.0%)
|105 (13.9%)
|Prior CABG
|240 (8.2%)
|46 (6.4%)
|130 (8.9%)
|64 (8.5%)
|Peripheral arterial disease
|217 (7.4%)
|48 (6.6%)
|113 (7.8%)
|56 (7.5%)
|1587 (54.2%)
|404 (55.9%)
|764 (52.6%)
|419 (55.6%)
|1192 (40.7%)
|308 (42.7%)
|573 (38.4%)
|311 (41.4%)
|Combined history of atherosclerosis
|1853 (63.2%)
|449 (62.1%)
|907 (62.3%)
|497 (65.9%)
|Family history of coronary artery disease
|581 (26.1%)
|144 (26.1%)
|282 (25.4%)
|155 (27.6%)
|Smoking status, n (%)
|874 (30.3%)
|214 (30.2%)
|445 (31.1%)
|215 (29.0%)
|785 (27.2%)
|180 (25.4%)
|395 (27.6%)
|210 (28.3%)
|Presenting characteristics
|Positive initial enzymes, n (%)
|1991 (70.5%)
|484 (69.4%)
|991 (70.2%)
|516 (72.1%)
|ST elevation or LBBB, n (%)
|843 (28.7%)
|201 (27.7%)
|430 (29.5%)
|212 (28.7%)
|ST depression or T wave inversion, n (%)
|1032 (35.1%)
|252 (34.7%)
|506 (34.7%)
|274 (36.2%)
|Systolic blood pressure, median (25th–75th percentiles), mmHg
|140 (120–160)
|140 (120–160)
|138 (120–156)
|140 (120–160)
|Diastolic blood pressure, median (25th–75th percentiles), mmHg
|80 (70–90)
|80 (70–90)
|80 (70–90)
|80 (70–90)
|Pulse (25th–75th percentiles), b.p.m.
|75 (64–87)
|75 (64–88)
|75 (64–86)
|75 (65–90)
|Killip class, n (%)
|2271 (79.0%)
|558 (79.3%)
|1118 (78.6%)
|595 (79.5%)
|524 (18.2%)
|127 (18.0%)
|267 (18.8%)
|130 (17.4%)
|68 (2.4%)
|18 (2.6%)
|31 (2.2%)
|19 (2.5%)
|11 (0.4%)
|1 (0.1%)
|6 (0.4%)
|4 (0.4%)
|Creatinine, median (25th–75th percentiles), mg/dL
|1.04 (0.90–1.22)
|1.06 (0.90–1.23)
|1.04 (0.90–1.21)
|1.03 (0.90–1.23)
|Serum cholesterol, median (25th–75th percentiles), mg/dL
|194 (166–228)
|194 (164–228)
|195 (166–228)
|193 (166–229)
|GRACE risk score
|Probability of in-hospital death or MI, median (25th–75th percentiles), %
|11 (8–17)
|11 (8–16)
|11 (7–17)
|11 (8–17)
|Probability of death or MI 6 months after discharge, median (25th–75th percentiles), %
|4 (3–8)
|4 (3–8)
|4 (3–8)
|5 (3–8)
|STEMI, n (%)
|768 (26.1%)
|178 (24.5%)
|397 (27.2%)
|193 (25.5%)
|Non-STEMI, n (%)
|1223 (41.6%)
|306 (42.1%)
|594 (40.7%)
|323 (42.7%)
|UA, n (%)
|833 (28.3%)
|213 (29.3%)
|420 (28.8%)
|200 (26.5%)
|Cardiac catheterization, n (%)
|1926 (65.8%)
|469 (64.7%)
|980 (67.4%)
|577 (63.7%)
|Three-vessel disease (>50% stenosis), n (%)
|445 (27.4%)
|108 (23.9%)
|231 (25.6%)
|106 (23.5%)
|Left main (>50% stenosis), n (%)
|138 (7.2%)
|24 (5.1%)
|76 (7.8%)
|38 (8.0%)
|PCI, n (%)
|1397 (47.5%)
|343 (47.2%)
|709 (48.6%)
|345 (45.8%)
|Thrombolytics, n (%)
|380 (13.2%)
|94 (13.2%)
|193 (13.5%)
|93 (12.6%)
|CABG, n (%)
|111 (3.8%)
|23 (3.2%)
|62 (4.3%)
|26 (3.5%)
Data were analysed by Kruskal–Wallis or χ2 test. Abbreviations are the same as in Table 1.
Although previous studies reported an association between rs1333049 and prevalent atherosclerosis in carotid vessels from healthy individuals,23 we only observed a weak trend towards association of rs1333049 and prior history of atherosclerosis, with carriers of two at-risk C alleles being slightly more common (26.8 vs. 24.9%; P = 0.19, Table 2). In addition, there was also no significant association between rs1333049 and three-vessel disease (P = 0.64).
Association of 9p21 with recurrent myocardial infarction or cardiac death
We then assessed whether 9p21 was also associated with recurrent atherothrombotic events. Survival analysis in the GRACE Genetics Study (n = 2942) revealed that rs1333049 was significantly associated with recurrent MI (n = 170) within the first 6 months after the primary event. This risk effect followed a dominant genetic model (see Supplementary material online, Table S2), in which the presence of any at-risk C allele predicted recurrent MI with an age- and gender-adjusted hazard ratio (HR) of 1.48 (CI = 1.00–2.19, P = 0.048) and a similar effect after multivariable adjustment (HR 1.47; CI = 0.99–2.18; P = 0.053; Table 3). The CIF illustrating that a recurrent MI is more common in C allele carriers vs. non-carriers is shown in Figure 1. Consistency with non-imputed data was confirmed by repeating the analysis without imputation and revealed comparable results (multivariable adjusted HR 2.30, CI = 1.27–4.09, P = 0.006). To further dissect this association with recurrent MI, genotype distributions of three additional SNPs in the 9p21 locus (rs7044859, rs1292136, and rs7865618), as well as their haplotype distributions, were studied. However, no additional relevant associations were detected (Supplementary material online, Tables S3 and S4).
|No recurrent MI
|Recurrent MI
|Age- and gender-adjusted
|2772 (94.2%)
|170 (5.8%)
|Genotypic, n (%)
|710 (25.6%)
|46 (27.1%)
|1.41 (0.89–2.23)
|1.34 (0.84–2.12)
|1367 (49.3%)
|93 (54.7%)
|1.52 (1.01–2.28)
|1.55 (1.03–2.33)
|695 (25.1%)
|31 (18.2%)
|Dominant, n (%)
|2077 (74.9%)
|139 (81.8%)
|1.48 (1.00–2.19)
|1.47 (0.99–2.18)
|695 (25.1%)
|31 (18.2%)
Data are analysed by a Cox proportional hazard model.
CI, confidence interval; HR, hazard ratio.
aAdjustments for: age, gender, history of angina, prior myocardial infarction, diabetes, current smoking status, systolic blood pressure, heart rate, total cholesterol, initial serum creatinine level, elevated initial cardiac enzymes, ST segment depression, Killip class, percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG), thrombolytics, and participating country.
Since cardiac death is often precipitated by ischaemic heart disease, we used a second combined endpoint consisting of recurrent MI or cardiac death. In agreement with the primary endpoint analysis, rs1333049 was significantly associated with recurrent MI or cardiac death (n = 205) within the first 6 months after the primary event (P = 0.045 and P = 0.028, respectively, after age- and gender-adjustment and multivariable adjustment; Table 4 and Figure 2). Consistency with non-imputed data was confirmed by repeating the analysis without imputation (multivariable adjusted HR 2.28, CI = 1.27–4.09, P = 0.0057).
|No recurrent MI or cardiac death
|Recurrent MI or cardiac death
|Age- and gender-adjusted
|2737 (93.0%)
|205 (7.0%)
|Genotypic, n (%)
|701 (25.6%)
|55 (26.8%)
|1.39 (0.82–2.37)
|1.33 (0.88–2.03)
|1347 (49.2%)
|113 (55.1%)
|1.69 (1.06–2.69)
|1.58 (1.09–2.30)
|689 (25.2%)
|37 (18.0%)
|Dominant, n (%)
|2048 (74.8%)
|168 (82.0%)
|1.58 (1.00–2.48)
|1.49 (1.03–1.98)
|689 (25.2%)
|37 (18.0%)
Data are analysed by a Cox proportional hazard model.
CI, confidence interval; HR, hazard ratio.
aAdjustments as in Table 4.
We also assessed whether the 9p21 genetic risk locus improved the prediction of a recurrent MI or cardiac death by quantifying the improvement in risk classification after adding rs1333049 into the GRACE risk score for recurrent MI.12 To this extend, the integrated discrimination improvement (IDI) index was used.20 Inclusion of rs1333049 into the prediction model showed a trend towards improved classification of recurrent MI at 6 months; this effect failed, however, to reach significance (P = 0.073). However, risk classification for the combined endpoint consisting of recurrent MI or cardiac death was significantly improved (P = 0.040): an additional 5.93% of the patients had an increased probability of being correctly classified after inclusion of rs1333049 into the model.
The GRACE Genetics Study was used to better characterize the 9p21 genetic risk locus for CAD. Our findings are relevant in several respects.
The most important finding is that the 9p21 locus predisposes to recurrent MI or cardiac death. Indeed, in ACS patients receiving optimal secondary prevention treatments, we found that carriers of the at-risk C allele exhibited an increased risk to develop a recurrent MI or cardiac death within 6 months after the primary event. Interestingly, the HR for developing a recurrent event in these carriers was higher than the risk of having a primary event (HR = 1.49 for recurrent MI or cardiac death vs. OR = 1.26 for primary ACS). This is remarkable, since patient populations with a primary ACS are already enriched for the rs1333049 at-risk C allele. In agreement herewith, the percentage of individuals carrying a C allele in the various patient groups increased gradually with the number of coronary events, i.e. 72.5% in healthy individuals compared with 74.9% in all primary ACS patients and as much as 81.8% in patients with a recurrent MI or cardiac death. The significant association of rs1333049 with recurrent MI or cardiac death could also generate intriguing insights into the biological role of 9p21 in CAD. Indeed, previous genetic studies investigating the 9p21 locus have used heterogeneous patient groups, consisting of stable CAD, coronary revascularization, or MI patients. Consequently, it has been impossible to conclude whether 9p21 drives atherosclerotic plaque formation, promotes plaque rupture, or triggers both. A study by Ye et al.,23 which demonstrates that 9p21 is associated with prevalence and 5 years progression of pre-clinical atherosclerosis in carotid vessels, suggests that 9p21 promotes plaque formation. It is therefore possible that GRACE patients carrying the rs1333049 allele develop more extensive atherosclerosis, and are more prone to a recurrent infarction. However, since we limited the follow-up period between the primary and recurrent event to 6 months, it is also possible −if not more likely− that recurrent events were due to subsequent rupture of pre-existing plaques. In this regard, our data also suggest a role for 9p21 in plaque rupture. Nevertheless, as long as the functional effect of rs1333049 on neighbouring genes is not known, it might be difficult to draw definite conclusions about the mechanisms by which rs1333049 exerts its effect on recurrent MI.
Our data may seem surprising since Horne et al.24 could not establish an association between the 9p21 locus and a combined endpoint of non-fatal MI and death, suggesting that 9p21 was not associated with MI. However, the differences in patient selection and outcome criteria between Horne's study and GRACE might explain why we did observe such association in the present study. Indeed, Horne et al. retrospectively selected patients from an angiographic database, which included stable and UA, and MI patients, while GRACE prospectively selected consecutive ACS patients only. As endpoint, Horne et al. used primary MI, recurrent MI, as well as all-cause moralities, whereas GRACE only considered recurrent MI and/or cardiac death.
Remarkably, the association of rs1333049 with recurrent MI or cardiac death was independent of all other risk factors, suggesting that rs1333049 may be used as an additional variable in clinical risk prediction models for recurrent MI. We tested this hypothesis using the GRACE risk score, which has been developed and validated for the robust prediction of cumulative 6 months risk of death or MI.12 We found that inclusion of rs1333049 into the GRACE risk score did not significantly improve risk classification for the prediction of recurrent MI (P = 0.073), but significantly improved risk classification of the combined endpoint of recurrent MI or cardiac death (P = 0.040) at 6 months using the integrated discrimination improvement method. It can therefore be anticipated that inclusion of additional genetic factors, which are likely to be identified in the near future, in combination with rs1333049 could enhance risk prediction models for adverse outcome following ACS.
Another finding of the study is that rs1333049 is a risk factor for primary ACS in two geographically different populations from the UK and Belgium. Although the primary reason for performing this analysis was to validate the GRACE Genetics Study, the findings from our case–control association study are of additional interest. Indeed, since the large majority of patients studied previously were a mixture of CAD or MI patients, which were either genetically enriched or exhibited early disease onset,3,4,9,10 risk effects in the latter cohorts may have been overestimated. However, in our prospective and consecutively collected GRACE Genetics Study, the risk associated with rs1333049 was largely comparable to that of previous reports: the odds ratio per C allele in the GRACE Genetics Study was 1.21 compared with 1.24 in the meta-analysis from Schunkert et al.9 Our study thus confirms that the risk associated with rs1333049 is applicable to patient populations as seen in clinical practice.
The strength of the GRACE Genetics Study is its specific design to capture an unselected and representative population of ACS patients with carefully characterized baseline and prospective follow-up data. In particular, standardized inclusion criteria and definitions of outcome events, which were independent of local interpretations in each of the participating clinical centres, were used. Another strength of the study is the inclusion of three geographically distinct populations, with variations in environmental risk factors and different incidence and prevalence rates for CAD. This suggests that the findings were not specific to a particular population or to a specific collection of risk factors in one country. It should be noted, however, that this study has also a number of limitations. First, we have used in the case–control study for primary ACS control populations that were not age- or gender-matched to the GRACE patients. However, since these control populations consisted of younger participants, which are yet to develop cardiovascular events, relatively more at-risk C allele carriers would be expected in these control populations compared with older cohorts, suggesting that our observed odds ratios would be an under-estimation, rather than over-estimation of the true risk effect. Second, since we do not have genome-wide SNP data for GRACE, we could not assess population substructure by multidimensional scaling or principal component analysis.25 A third limitation is the small effective sample size of the recurrent MI or cardiac death population. Indeed, only 5.8 (n = 170) and 7.0% (n = 205) of all primary ACS patients developed a recurrent MI or recurrent MI/cardiac death event. Additional replication studies are therefore needed to confirm our findings. Finally, periprocedural MI was not part of the initial case record form in GRACE, thereby precluding a sub-analysis excluding periprocedural MI from the endpoints. Because we only included a recurrent MI occurring at 24 h or later after the primary event and because periprocedural MI occurs in the majority of the patients within the first 24 h, we expect that most periprocedural MIs will automatically have been excluded by this definition.
In conclusion, our study confirms that the 9p21 locus confers a risk for primary ACS in an unselected patient population. Importantly, we also provide unprecedented evidence that the 9p21 locus is independently associated with recurrent MI or cardiac death following an acute coronary event. Since the follow-up period between the primary and recurrent event was restricted to 6 months, our data suggest that the 9p21 locus—in addition to promoting plaque formation—might also be involved in stimulating plaque instability and rupture. Finally, we provide suggestive evidence that prediction models for recurrent events might be complemented by genetic risk factors such as the 9p21 locus.
Supplementary material
Supplementary material is available at European Heart Journal online.
Funding for the project was provided by the Wellcome Trust under award 076113.3 GRACE is supported by an unrestricted educational grant from Sanofi-Aventis to the Center for Outcomes Research, University of Massachusetts Medical School. Phenotypic characterization and DNA extraction were funded by an award from the British Heart Foundation (CH/92010) to K.A.A.F. Genotyping was funded by a 'Fonds voor Wetenschappelijk onderzoek' (FWO) 'Krediet aan Navorsers' grant (1516009N) to D.L. The Asklepios Study was funded by a FWO research grant (G042703) to E.R. D.R.D. was funded by the Wellcome Trust Cardiovascular Research and Cardiovascular Functional Genomics Initiatives, and by a British Heart Foundation CoRE award. D.L. was supported by the FWO. We are grateful to Désiré Collen and the Life Sciences Research Partners VZW (LSRP) for providing access to the MassARRAY Compact Analyser (Sequenom). None of the funding organizations had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Conflict of interest: none declared.
We thank the patients, physicians, and nurses participating in the GRACE, Asklepios, and WTCCC studies. This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. We thank Laura De Velder for her excellent assistance to this study.
↵† These authors contributed equally to this work.
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: email@example.com


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Jennifer Hudson and Timbaland keep it sexy on new song 'Walk It Out'
You gotta treat her like a lady
Jennifer Hudson has tapped super-producer Timbaland for her soulful new single "Walk It Out." Listen below.
The nearly five-minute jam pairs Hudson's diva vocals with old-school beats and R&B samples. In addition to his producer credit alongside J-Roc, Timbaland jumps into the song with playful ad-libs. JHud confidently delivers sultry lines like, "I know you wanna take me to your room / And I wanna go your way / But you gotta treat me like a lady."
"Walk It Out" will be featured on Hudson's follow-up to 2011's "I Remember Me," slated for release this summer. Earlier this year, Hudson revealed that she's also collaborating with Pharrell Williams and R. Kelly on the new album.


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My Beautiful Sunday ... friends, trying something new and snow! Ruth, Amber, mom and I went the Vajralama Buddhist Center this morning. Drove Ruth to the airport in the snow! Drove home in more snow. Stopped by Urban Pottery and found a belated birthday present for my favorite neighbor and some Christmas decoration for the kitchen cabinet. All in all we had the perfect Sunday -- except that Ruth had to go back to Texas!
Sunday, November 26, 2006
Beautiful Sunday -- Temple And Snow
Posted by Kim Carney at 8:12 PM
1 comment:
- la vie en rose said...
as always your photos are breathtaking. i had some more fun with the seamless studio over the holiday. got a lot of fun pics...
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Martin McAndrewShared publicly -
Very excited about the fledging chicks we might see coming from the Blue Thirst bird box for the first time today.
Blue Thirst Bird Box. We are very excited we thing we might see Kevin & Sheila's or resident great tit family's new chicks today.
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realmagick.com The shrine of knowledge.
A selection of articles related to states.
Original articles from our library related to the States. See Table of Contents for further available material (downloadable resources) on States.
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Mind >> Telepathy and Group Mind
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Mind >> World Mind
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Mind >> World Mind
- Manifesting World Enlightenment: Part 5
- All things in the universe have at their basis, one fundamental essence which governs their creation, destruction and on-going actions. That singular essence is consciousness, (also known by some as God, or the Unified Field). Everywhere in Nature does...
Mind >> World Mind
- Hypnosis: A Selected Bibliography
- Index of bibliography sections Selected Periodicals (14 entries) Edited Overviews of General Theories of Hypnosis (5 entries) Specific Topics Related to Research into Hypnosis. General single-author overviews, non-special-state views, social andexperimental...
Parapsychology >> Hypnosis
- Raising the World Mind (GM10-11)
- Part 1 | Part 2 Part 1 The wise live in accord with natural laws. It is they who understand that the laws of nature are much higher than the laws of man, because breaking them implies penalties far greater than a fine or prison sentence. When a person...
Mind >> World Mind
- Manifesting World Enlightenment: Part 3
- One of the very best ways to raise personal or group consciousness, is to MANIFEST spiritual Intentions into the environment at large. The projection of love into one's surroundings for instance, results in love being reflected back to the sender, like...
Mind >> World Mind
States is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, States books and related discussion.
Suggested News Resources
- Which States Have Winner-Take-All Primaries Or Caucuses? Some Big Ones Are On
- As Donald Trump comes perilously close to collecting the 1,237 delegates needed to clinch the Republican nomination, all eyes are on Florida and Ohio, two big winner-take-all states that will award their delegates on Tuesday, March 15. The idea of a ...
- What the data says about the States of the State
- Minnesota Governor Mark Dayton works his way down the aisle shaking hands after finishing his annual State of the State Address in the House Chambers of the State Capitol in St. Paul on Thursday, April 9, 2015. (Pioneer Press: Scott Takushi).
- What These State Environmental Officials Say Obama's EPA Has Forced on Them
- The Environmental Protection Agency has overstepped its legal authority by imposing a regulatory agenda on the states, environmental officials at the state level testified Wednesday to a Senate committee. Randy Huffman, cabinet secretary at the West ...
- Venezuela withdraws top diplomat in United States
- Maximilien Arvelaiz acted as Venezuela's charge d'affaires in Washington and had been waiting for months to be allowed to act as ambassador to the United States. The two countries have not shared ambassadorial ties since 2010. The United States ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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text:
The people who like to portray Labour as living in cloud-cuckoo land are the sort of people who'd take a financial hit from a Labour administration. They're some of the richest people in the country, and they're squealing at the thought of seeing some of their advantages go swirling down the plughole.
Students have been arrested, sprayed with tear gas and threatened with tasers at the University of Warwick, after a peaceful education protest turned violent on Wednesday.
The real mystery is how the UK economy has managed to do so well in the recent past given the performance of our neighbours. The general consensus is that this momentum will not continue and that growth will slow next year. The risk is that growth slows more quickly than expected and that we find ourselves in a similar position to the rest of Europe as inflation continues to decline.
Record numbers of students are attending university this year and young people choosing to further their education is something that I'm hugely in favour of. What I can't support, however, is a free for all in universities which simply don't have the infrastructure to deal with the rising numbers, but who are happy to benefit financially from them...
We are angry. Tuition fees are £9,000. Student debt on graduation now averages over £40,000... Our debts are on a scale unthinkable even a decade ago. Life-shaping debts. Debts so large that they determine what jobs we look for, where we live and even whether to start a family.
Labour would be best rethinking this potential pledge before it is announced. A cut in tuition fees from £9,000 to £6,000 will not help Labour successfully captured the student vote. It will instead send a message to students that they agree with the tuition fees policy implemented by the coalition.
A wondrous event took place in London town last night. A premiere like no other, vInspired's Swing The Vote set out to reveal what's remained a secret 'til now: exactly what will get the UK's 18-24 year olds to the ballot box next summer.
When people steal from the state through benefit fraud (usually out of desperation), there's public outcry. But when the state steals from the people by failing to provide even a basic standard of living, whilst corruption and tax evasion runs unchecked, we're told it's all part of a necessary strategy for economic recovery.
How universities can expect Arts students, for example, to pay £9,000 for a reading-based degree with the essential ingredients not included, I don't know... Expensive reading lists are an irritating, tiresome and unnecessary addition to the financial burden already placed on students, and it makes the annual £9,000 tuition fee seem even more of a rip-off than we originally thought.
Too many academics still spend too much of their time in ivory towers and not engaging their students... modern students want to change this. Academics will have to change too.
After four years as a Soas student, I'm about to graduate with a considerable amount of debt, albeit not compared to those now paying historic £9000 ...
I'm not a particularly political person. I am not a Marxist, a Socialist, a Conservative, a Liberal...I find it all a bit bewildering to be honest. And I'm not alone. For though most people have a plethora of views about the huge problems facing the country at the moment...
New survey reveals major shortfall in UK student income vs living costs, and exposes growing tensions between parents, students and the government. ...
What is clear is that universities are being forced to make pricing decisions and think like commercial businesses like never before. True marketisation may not be a bad thing for the sector - with fees genuinely linked to the value delivered - but the current model is the worst of both worlds.
By talking to businesses we are no longer making assumptions and as a result we have found that some curriculum units are not the highest priority from an employer perspective, and as a result the content has been changed, and we know this collaborative approach must continue.
We won't win free education overnight; it will take long years of debate, proving the public value of higher education to the public and we will need to tackle the issue of access to education, so a mature student from Tower Hamlets has the same chance of getting into UCL as their 18 year-old counterpart from Richmond.


text:
Jardine Davies Building 222 Senator Gil Puyat Avenue Data Communication Systems, Equipment & Service ComputerComputer Related ServicesComputer Services
- Evaluations of Jardine Direct Company:
892 times viewed 37 times listed
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Nhoralex ISP - Butuan ; IT Services; Filinvest Information Technology Inc. (FITI) Jardine Direct Company Inc. MEDIA; Philippine Journalists Group more
Certified Organisation. Jardine Direct Company Inc. Jardine Direct Company Inc. is a certified organisation under the itSMF ISO/IEC 20000 Certification scheme. more
Senior Software Engineer at Accenture, Local Area Network Administrator at Jardine Direct Company Inc\ Education: Pamantasan ng Lungsod ng Maynila more
We are one of the largest communities in Asia Pacific with over 9 million job seeker members and more than 150,000 corporate clients, offering at least 100,000 job opportunities ... more
Company profile DIRECT DIAMOND DRILLING, SHEFFIELD, 38 JARDINE STREET, demolition site clearance Direct Diamond Drilling Ltd is a very effective specialist contractor giving ... more
We are one of the largest communities in Asia Pacific with over 9 million job seeker members and more than 150,000 corporate clients, offering at least 100,000 job opportunities ... more
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text:
Pms Humor
When my period starts, I look back on the past few days... And then everything makes sense.
My typical day of PMS: 1-Eat ALL of the food! 2-Cry about it 3-Get mad at ALL of the people! 4-Cry about it 5- Repeat.
I'm so pissy, I'm pissing myself off. #karenmalcolm Because Karen wanted a meme.
Funny Pictures Of The Day - 36 Pics
The accuracyyyy pinterest : @ вσηνtα ☪
pinterest: @jaidyngrace More
Funny Minion Pictures Of The Week
#periods #pms #humor
Feel that familiar pain and rage coming on? It's your uterus' way of telling you that you're going to be out of commission for the next week. | 16 Ways to Make PMS Suck Less


text:
The Top Plastic Surgeon in Chicago's Gold Coast, Illinois
Meet your Doctor:
Anil R. Shah, M.D.
875 N Michigan Ave #3850, Chicago, IL 60611
Make an Appointment:
For your FREE consultation or for more information on setting up an appointment with Dr. Anil R. Shah, please fill out the below contact form. Or, feel free to e-mail: email@example.com
We make it our priority to return all communication within 24 hours.
Phone: (312) 544-0620
Email: firstname.lastname@example.com
Address: 875 N Michigan Ave #3850, Chicago, IL 60611


text:
Psyc 210 - homeworktips.org
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Remember @2x
The kings finally released the real single. Get Lucky.
Can't help to celebrate and get down with some illustration of the Guy-Manuel helmet to my Acosmos collection.
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What do you guys think of SMBC?
I think it's well thought out...except for Megaman's jumps...But the latest version is awesome.
I'm back!
"Concise and devoid of elegance...what I have come to expect from human communication"-Endless Summer
Its an awesome idea but I no longer have a gamepad for my pc so playing any ROM is intolerable without it. Its just not the same lol using arrows and space... I just cant pull it off... Will try it in its entirty once I find my gamepads tho.


text:
Hôtel Le Golf - Bourg-Saint-Maurice
Your hotel has 3 restaurants serving breakfast and dinner where you'll find good menu choices and service with a smile. If you are planning on a spot of skiing during your stay, not only will you find ski runs nearby, but also facilities such as ski-in/ski-out access, ski passes, ski storage, skiing lessons and ski rentals. Nearby winter fun includes snowboarding. Escape the stress of everyday life at Deep Nature, offering facials and sports massages, as well as body treatments, a steam room and a sauna. Relax in the indoor pool and seasonal outdoor pool during your stay. The bar/lounge is a perfect place to have a drink.
In addition to the on-site spa, a Turkish bath/hammam and a sauna are among the leisure facilities on offer. Free WiFi is provided so you can check your in-box whenever you like.
Great place to stay to ski Les Arcs
Hôtel Le Golf - Bourg-Saint-Maurice
Hotel Info: 1-877-214-4288from $58
- Standard Room
- Junior Suite
- Deluxe room
- Superior Room
- Triple Room
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 246 rooms
- This hotel is arranged over 6 floors
- Check-in time starts at 4 PM
- Check-out time is 10 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed *
- Restrictions apply *
- 1 per room (up to 10 kg)
- Free WiFi in public areas
- Free WiFi in rooms
In the hotel
- Supervised childcare/activities
- Breakfast (surcharge)
- 3 restaurants
- Bar/lounge
- Coffee shop/café
- Snack bar/deli
- Indoor pool
- Outdoor seasonal pool
- Ski-in/ski-out access
- Ski storage
- Golf course on site
- Full-service spa
- Spa treatment room(s)
- Ski passes available
- Steam room
- Sauna
- Number of meeting rooms - 11
- Conference space
- 24-hour front desk
- Free newspapers in lobby
- Porter/bellhop
- Number of buildings/towers - 1
- Year Built 1975
- Safe-deposit box at front desk
- Television in common areas
In the room
- Minibar
- Blackout drapes/curtains
- Private bathroom
- Bathtub only
- Hair dryer
- Flat-screen TV
- Satellite TV channels
- Free WiFi
- Daily housekeeping
- In-room safe
- Connecting/adjoining rooms available
Special features
Deep Nature has 4 treatment rooms including rooms for couples. Services include sports massages, massages, facials, and body treatments. The spa is equipped with a sauna, a spa tub, a steam room, and Turkish bath/hammam.
Children under 16 years old are not allowed in the spa without adult supervision. Guests under 6 years old are not allowed in the spa.
DiningLe Golf - This restaurant specializes in French cuisine and serves breakfast and dinner.
Brasserie Le Petit Zinc - This theme restaurant specializes in local cuisine and serves lunch and dinner. Open select days.
Restaurant Le Mont Blanc - This restaurant specializes in fondue and serves dinner only. Open select days.
- Ski-in/ski-out access
- Ski passes available
- Ski storage
- Ski lifts nearby
- Ski runs nearby
- Ski lessons on site
- Ski equipment rentals on site
- Snowboarding nearby
- Snowmobiling nearby
- Snowshoeing nearby
Hôtel Le Golf - Bourg-Saint-Maurice's small print
Also known as
- Hôtel Le Golf
- Hôtel Le Golf Bourg-Saint-Maurice
- Le Golf Bourg-Saint-Maurice
- Hôtel Golf Bourg-Saint-Maurice
- Golf Bourg-Saint-Maurice
Guests must contact this hotel in advance to reserve a rollaway/extra bed in the Superior Room only. Please contact the office using the information on the reservation confirmation received after booking.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Guests under 16 years old are not allowed in the spa tub.
Children under 16 years old are not allowed in the spa without adult supervision.
Guests under 6 years old are not allowed in the spa.
Reservations are required for golf tee times, massage services, and spa treatments and can be made by contacting the property before arrival at the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 1.1 per person, per night
Optional extras
Early check-in can be arranged for an extra charge of EUR 90
Late check-out can be arranged for an extra charge of EUR 90
Breakfast is offered for an extra charge of EUR 16 for adults and EUR 7.00 for children (approximately)
Pets are allowed for an extra charge of EUR 10 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
I was wondering why a carrier decides to operate both the 777's and 340's. It couldn't be too economically sound.
Partial List :
AirFrance - They owe it to their homeland?
China Southern - ?
Emirates - ?
Cathay ?
Egyptair - they are phasing the 777's out.
singapore - ?


text:
Browsing by Author "Colbourn, Charles J."
Now showing items 1-1 of 1
Cluttered orderings for the complete graph Cohen, Myra B.; Colbourn, Charles J.; Fronček, Dalibor (Computing and combinatorics : 7th Annual International Conference, COCOON 2001, Guilin, China, August 20-23, 2001. Proceedings. 2001, p. 420-431. Lecture notes in computer science, vol. 2108.)


text:
Since I cant post anywhere near the correct forum, i'm posting here,
I am unable to manage my photos on myavaition.net.
I've requested a password change - NOTHING
I've requested a new login - NOTHING.
Can you please get this sorted as I want to edit some information on my photographs.


text:
Ladainian Tomlinson College Career
A selection of articles related to ladainian tomlinson college career.
Original articles from our library related to the Ladainian Tomlinson College Career. See Table of Contents for further available material (downloadable resources) on Ladainian Tomlinson College Career.
- What day are you born on?
- The day of the month on which the you were born - regardless of which month or year it is - is a key numerological indicator, providing an excellent "thumbnail sketch" of standout traits. It strongly influences your Life Path and is helpful in...
Symbology >> Numerology
- Hulse, David Allen
- From an early age, David Allen Hulse has made a diligent study of the alphabets of the ancient world. Even as a child, David possessed a great affinity for the alphabets of Egypt, Phoenicia, and Greece. In college, a reading of MacGregor Mathers' Kabbalah...
Real Interviews >> Authors
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
- Hulse, David Allen
- >From an early age, David Allen Hulse has made a diligent study of the alphabets of the ancient world. Even as a child, David possessed a great affinity for the alphabets of Egypt, Phoenicia, and Greece. In college, a reading of MacGregor Mathers' Kabbalah...
Real Interviews >> Authors
- Religious Tolerance In Springfield and the Greenleaf Coven
- Religious intolerance is alive and well in Springfield Missouri. The question is, to what degree, and in the terminology of "The Burning Times", how high are the flames? In 1999, the court case of Jean Webb vs. The City of Republic was a headliner...
Paganism & Wicca >> True Stories
- A New Look at Divination: Everyday methods are simpler than you think!
- When we think of divination, we often think of tarot, runes, or other ancient and cryptique mystical techniques. While these methods have long stood the test of time, we can make use of many common objects which surround us every day. A variety of magical &quo...
Psychic Abilities >> Divination
- Sepia (Squid Ink)
- Sepia is the ink from a squid. The squid usually lives alone, it is an independent individual. In case of fear or danger they surround themselves with a hiding cloud of dark ink. When we project this image on human beings we find that the homoeopathic Sepia...
Remedies >> Remedies S
Ladainian Tomlinson College Career is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Ladainian Tomlinson College Career books and related discussion.
Suggested News Resources
- Boykin: Maurice Clarett, LaDainian Tomlinson offered advice
- INDIANAPOLIS—After Trevone Boykin's college career ended abruptly, he got a call from an unlikely new friend: Maurice Clarett. Just two days before the TCU quarterback was supposed to lead the Horned Frogs against Oregon in the Alamo Bowl on Jan.
- TCU alum LaDainian Tomlinson thinks the Cowboys should pass on a QB at No. 4
- San Diego Chargers LaDanian Tomlinson (21) throws up the TCU Horned Frogs symbol after scoring a first quarter touchdown as the Dallas Cowboys host the San Diego Chargers at Cowboys Stadium in Arlington on Sunday, December 13, 2009.
- Let's Soar
- This idea was my biggest motivation in starting SOAR to Success and the LT Preparatory Academy. With SOAR ... SOAR offers students in ninth grade a road map to follow throughout their high school careers in order to earn a college scholarship.
- Matt Forte-to-Jets evokes memories of LaDainian Tomlinson, circa 2010
- Welcome back to 2010. That year, the Jets cut Thomas Jones in a cap-related move and signed an aging legend, LaDainian Tomlinson. And you know what?
- Andy Dalton is throwing again after thumb injury cut season short
- On Wednesday, Dalton joined LaDainian Tomlinson, Mike Renfro and Lyle Blackwood at the TCU Legends Luncheon benefiting Meals on Wheels of Tarrant County at the Fort Worth Club.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Ladainian Tomlinson College Career Topics
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COLUMBIA (WACH) -- South Carolina Highway Patrol gives driving tips for possible winter weather.
With the threat of a dose of winter weather Friday, the South Carolina High Patrol is reminding drivers to be safe while on South Carolina roads.
Winter Weather Driving Tips
Driving safely on icy roads:
- Decrease your speed and leave yourself plenty of room to stop. You should allow at least three times more space than usual between you and the car in front of you.
- Brake gently to avoid skidding. If your wheels start to lock up, ease off the brake.
- Turn on your lights to increase your visibility to other motorists.
- Keep your lights and windshield clean.
- Use low gears to keep traction, especially on hills.
- Don't use cruise control or overdrive on icy roads.
- Be especially careful on bridges, overpasses and infrequently traveled roads, which will freeze first. Even at temperatures above freezing, if the conditions are wet, you might encounter ice in shady areas or on exposed roadways like bridges.
- Don't pass snow plows and sanding trucks. The drivers have limited visibility, and you're likely to find the road in front of them worse than the road behind.
- Don't assume your vehicle can handle all conditions. Even four-wheel and front-wheel drive vehicles can encounter trouble on winter roads.
If your rear wheels skid...
- Take your foot off the accelerator.
- Steer in the direction you want the front wheels to go. If your rear wheels are sliding left, steer left. If they're sliding right, steer right.
- If your rear wheels start sliding the other way as you recover, ease the steering wheel toward that side. You might have to steer left and right a few times to get your vehicle completely under control.
- If you have standard brakes, pump them gently.
- If you have anti-lock brakes (ABS), do not pump the brakes. Apply steady pressure to the brakes. You will feel the brakes pulse -- this is normal.
If your front wheels skid...
- Take your foot off the gas and shift to neutral, but don't try to steer immediately.
- As the wheels skid sideways, they will slow the vehicle and traction will return. As it does, steer in the direction you want to go. Then put the transmission in "drive" or release the clutch, and accelerate gently.
If you get stuck...
- Do not spin your wheels. This will only dig you in deeper.
- Turn your wheels from side to side a few times to push snow out of the way.
- Use a light touch on the gas, to ease your car out.
- Use a shovel to clear snow away from the wheels and the underside of the car.
- Pour sand, kitty litter, gravel or salt in the path of the wheels, to help get traction.
- Try rocking the vehicle. (Check your owner's manual first -- it can damage the transmission on some vehicles.) Shift from forward to reverse, and back again. Each time you're in gear, give a light touch on the gas until the vehicle gets going.
You can check road conditions from SCDOT online during winter weather events. This is especially helpful if you need to travel to areas that experienced different weather conditions than the Midlands.
For the latest forecast from the SkyWACH Weather Team click here.


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895 W Trade St, Gateway Center, Charlotte, NC, 28202, United States of America, 855-239-9478
DoubleTree by Hilton Hotel Charlotte
Lowest price$139
Situated in Charlotte Center City within a 20-minute walk of Ray's Splash Planet and Bank of America Stadium, DoubleTree by Hilton Hotel Charlotte offers 3.5-star Charlotte hotel accommodations. Time Warner Cable Arena is 0.9 mi (1.5 km) away.
This hotel has its own restaurant serving breakfast, lunch and dinner where you'll find a selection of items to try. Go for a dip in the outdoor pool during your stay. Guests can also enjoy drinks as there is a bar/lounge.
This hotel has its own restaurant serving breakfast, lunch and dinner where you'll find a selection of items to try. Go for a dip in the outdoor pool during your stay. Guests can also enjoy drinks as there is a bar/lounge.
The leisure facilities include a fitness center. Free WiFi and high-speed (wired) Internet access is provided.
See all 381 Venere.com reviews
Fantastic service
Delicious food
Great location
Value for money
Value for money could be better
TripAdvisor Traveller Rating: 4
From 760 reviews
DoubleTree by Hilton Hotel Charlotte
Hotel Info: 855-239-9478from $139
- Room, Accessible, Non Smoking
- One King Accessible Bathtub Non-Smoking
- Room, Accessible, Non Smoking
- Standard Two Doubles
- Room, 1 King Bed, Accessible, Non Smoking
- Standard King
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 187 rooms
- Check-in time 3 PM-midnight
- Check-out time is noon
- Express check-out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 21
Travelling with others
- Pets not allowed
- Free WiFi and wired Internet access in public areas
- Free WiFi and wired Internet access in rooms
- Self parking *
In the hotel
Food and drink
- Breakfast (surcharge)
- Restaurant
- Bar/lounge
- Coffee shop/café
- Room service (during limited hours)
Things to do
- Outdoor pool
- Fitness facilities
Working away
- Business center
- Conference space
- Meeting rooms 4
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Multilingual staff
- Elevator/lift
- Safe-deposit box at front desk
- Accessible bathroom
- In-room accessibility
- Roll-in shower
In the room
Home comforts
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
Freshen up
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
Be entertained
- Pay movies
- Premium TV channels
Stay connected
- Desk
- Free weekday newspaper
- Free WiFi
- Phone
Food and drink
- Refrigerator
- Daily housekeeping
- In-room safe
Special features
DiningOrchards Restaurant - This restaurant serves breakfast, lunch, and dinner.
DoubleTree by Hilton Hotel Charlotte's small print
Also known as
- Charlotte DoubleTree
- Charlotte DoubleTree Hotel
- DoubleTree Charlotte
- DoubleTree Hilton Charlotte
- DoubleTree Hilton Hotel Charlotte
- DoubleTree Hotel Charlotte
- Hilton DoubleTree Charlotte
- Hilton Hotel Charlotte
Optional extras
Self parking costs USD 14 per night
Rollaway beds are available for USD 25 per stay
Breakfast costs between USD 10 and USD 25 per person (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
Group Booking Terms and Conditions
Because you are making a Group Booking, there are additional Terms and Conditions that apply. Please read them and click 'I Accept' below to continue with your booking
Hostel Specific Terms & Conditions
The remainder of the amount due will be charged to your credit card on arrival. Should numbers or room selection change, the per person deposit times the number of people who actually travelled will be deducted from the total accommodation charge levvied by the hostel.
The following group types are not accepted by this hostel: Holiday with Friends, Junior / Primary School, High / Secondary School, College / University, Business Trip, Stag/Hen/Bachelor Party, Sports Group, Cultural Group If you have misrepresented the type of group you are booking for, your booking may be cancelled by the hostel.
Any cancellations resulting from agreement to these terms and conditions under false pretences will result in loss of deposit.
General Group Booking Terms
By making a group reservation through Hostelworld.com you agree to the following terms and conditions as set by Hostelworld.com and as set by the hostel in question.
- In order to make a group reservation on Hostelworld.com it is necessary to pay a deposit. The balance is due directly to the hostel according to their payment conditions.
- The booking deposit is non-refundable
- Hostelworld.com are not responsible for changes or amendments to your reservation once it has been processed. All correspondence with regard to changes to your booking need to be dealt with directly with the hostel.
- Cancellations for reservations must be made directly with the hostel and must conform with the individual hostels cancellation policy (see below)
- It is your responsibility to pay the balance of your accommodation cost to the hostel in accordance with their payment conditions (see below). Failure to do so may result in your reservation being cancelled by the hostel.
- Individual hostels may have special booking conditions relating to group stays, please read the hostel booking conditions carefully before making your reservation.
Você deve aceitar os termos e condições para que possamos confirmar sua reserva.
Selling Out Soon
Descrição do estabelecimento
Avaliação mais recentetraduzido peloVer todos os comentarios
" Eu nunca tinha tido uma comunicação mais profissional com um negócio como eu tive com La Dimora. Chegando no tempo e fazê-lo ao Bed and Breakfast em tempo recorde considerando sua localização em um labirinto de ruas que um táxi não pode chegar. As portas para o complexo estava fechada, ninguém iria responder. Foi bloqueado não podíamos entrar e ficou fora lá para vinte minutos a tentar contactá-los. Toda vez que ligamos eles iriam desligar. Nós terminou para encontrar um outro lugar. Grand Duomo Hotel, maravilhoso! "- Anônimo
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