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Full clearinghouse
SCP initiatives
The worldwide SCP initiatives database aims to be a great source of inspiration, which gathers information about existing initiatives (e.g. policies, partnerships, projects, etc.) developed and implemented at all levels by governments, international/regional organizations, the business sector or civil society. The boundaries and names shown and the designations used on this map do not imply official endorsement or acceptance by the United Nations.


text: Located in Bogota (Old Town La Candelaria), Ambar Hotel is minutes from Emerald Museum and Iglesia de la Tercera Orden. This boutique hotel is close to Plaza de Bolivar and Monserrate. Make yourself at home in one of the 48 guestrooms featuring minibars and flat-screen televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers. Make use of convenient amenities, which include complimentary wireless Internet access and tour/ticket assistance. Enjoy a meal at a restaurant, or stay in and take advantage of the hotel's room service (during limited hours). Featured amenities include dry cleaning/laundry services and a 24-hour front desk.

subset: commoncrawl


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UPDATE: Credit Suisse Downgrades U.S. Bancorp
In a report published Wednesday, Credit Suisse analyst Jill Shea downgraded U.S. Bancorp (NYSE: USB) to Neutral from Outperform, raising its price target to $44.00 from $40.00.
According to the report, USB continues to distinguish itself from peers with its diversified earning stream, conservative operating philosophy and leading returns. The revised price target of $44.00 implies 8 percent upside and not enough to justify the previous Outperform rating.
"While there are many attributes about the operating performance of US Bancorp that are enviable, we see more upside in other large cap stocks at lower valuations which are poised to generate higher earnings growth next year," the report said. "Our top pick is Citigroup followed by JPMorgan Chase. We see less upside in USB shares over the near-term given expectations for modest revenue growth and less in the way of expense leverage given its already leading efficiency ratio relative to peers."
USB closed Tuesday at $40.93.
Latest Ratings for USB
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Posted-In: Credit Suisse Jill SheaAnalyst Color Downgrades Analyst Ratings
© 2016 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.


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Most Cited Ageing Research Reviews Articles
The most cited articles published since 2011, extracted from Scopus.
Aging with multimorbidity: A systematic review of the literatureAlessandra Marengoni | Sara Angleman | René Melis | Francesca Mangialasche | Anita Karp | Annika Garmen | Bettina Meinow | Laura Fratiglioni
Volume 10, Issue 4, September 2011, Pages 430-439
A literature search was carried out to summarize the existing scientific evidence concerning occurrence, causes, and consequences of multimorbidity (the coexistence of multiple chronic diseases) in the elderly as well as models and quality of care of persons with multimorbidity. According to pre-established inclusion criteria, and using different search strategies, 41 articles were included (fofur of these were methodological papers only). Prevalence of multimorbidity in older persons ranges from 55 to 98%. In cross-sectional studies, older age, female gender, and low socioeconomic status are factors associated with multimorbidity, confirmed by longitudinal studies as well. Major consequences of multimorbidity are disability and functional decline, poor quality of life, and high health care costs. Controversial results were found on multimorbidity and mortality risk. Methodological issues in evaluating multimorbidity are discussed as well as future research needs, especially concerning etiological factors, combinations and clustering of chronic diseases, and care models for persons affected by multiple disorders. New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients. © 2011 Elsevier B.V.
Inflammatory markers in population studies of agingTushar Singh | Anne B. Newman
Volume 10, Issue 3, July 2011, Pages 319-329
Purpose: To review findings from major epidemiologic studies regarding risk factors for and consequences of elevated markers of inflammation in older adults. Results: Most large, current epidemiologic studies of older adults have measured serum interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha) and some studies also include more extensive batteries of measures including soluble receptors. There are few defined risk factors for the modest elevations in inflammatory markers seen with aging. These include visceral adiposity, lower sex steroid hormones, smoking, depression and periodontal disease. Of the markers assessed, IL-6 is most robustly associated with incident disease, disability and mortality. Conclusion: Though correlated with age, the etiology of elevated inflammatory markers remains incompletely defined. Inflammation, especially IL-6 may be a common cause of multiple age-related diseases or a final common pathway by which disease leads to disability and adverse outcomes in older adults. Future research targeting inflammation should examine these pathways. © 2011.
Oxidative stress and cancer: An overviewVenus Sosa | Teresa Moliné | Rosa Somoza | Rosanna Paciucci | Hiroshi Kondoh | Matilde E. LLeonart
Volume 12, Issue 1, January 2013, Pages 376-390
Reactive species, which mainly include reactive oxygen species (ROS), are products generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. In normal cells, low-level concentrations of these compounds are required for signal transduction before their elimination. However, cancer cells, which exhibit an accelerated metabolism, demand high ROS concentrations to maintain their high proliferation rate. Different ways of developing ROS resistance include the execution of alternative pathways, which can avoid large amounts of ROS accumulation without compromising the energy demand required by cancer cells. Examples of these processes include the guidance of the glycolytic pathway into the pentose phosphate pathway (PPP) and/or the generation of lactate instead of employing aerobic respiration in the mitochondria. Importantly, ROS levels can be used as a thermostat to monitor the damage that cells can bear. The implications for ROS regulation are highly significant for cancer therapy because commonly used radio- and chemotherapeutic drugs influence tumor outcome through ROS modulation. Moreover, the discovery of novel biomarkers that are able to predict the clinical response to pro-oxidant therapies is a crucial challenge to overcome to allow for the personalization of cancer therapies. © 2012 Elsevier B.V.
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling networkAntero Salminen | Kai Kaarniranta
Volume 11, Issue 2, April 2012, Pages 230-241
Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified cellular housekeeping are the hallmarks of improved healthspan and extended lifespan. AMPK signaling is involved in the regulation of all these characteristics via an integrated signaling network. Many studies with lower organisms have revealed that increased AMPK activity can extend the lifespan. Experiments in mammals have demonstrated that AMPK controls autophagy through mTOR and ULK1 signaling which augment the quality of cellular housekeeping. Moreover, AMPK-induced stimulation of FoxO/DAF-16, Nrf2/SKN-1, and SIRT1 signaling pathways improves cellular stress resistance. Furthermore, inhibition of NF-κB signaling by AMPK suppresses inflammatory responses. Emerging studies indicate that the responsiveness of AMPK signaling clearly declines with aging. The loss of sensitivity of AMPK activation to cellular stress impairs metabolic regulation, increases oxidative stress and reduces autophagic clearance. These age-related changes activate innate immunity defence, triggering a low-grade inflammation and metabolic disorders. We will review in detail the signaling pathways of this integrated network through which AMPK controls energy metabolism, autophagic degradation and stress resistance and ultimately the aging process. © 2011 Elsevier B.V.
Protein homeostasis and aging: The importance of exquisite quality controlHiroshi Koga | Susmita Kaushik | Ana Maria Cuervo
Volume 10, Issue 2, April 2011, Pages 205-215
All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable and functional proteome. A progressive deterioration in the ability of cells to preserve the stability of their proteome occurs with age and contributes to the functional loss characteristic of old organisms. Molecular chaperones and the proteolytic systems are responsible for this cellular quality control by assuring continuous renewal of intracellular proteins. When protein damage occurs, such as during cellular stress, the coordinated action of these cellular surveillance systems allows detection and repair of the damaged structures or, in many instances, leads to the complete elimination of the altered proteins from inside cells. Dysfunction of the quality control mechanisms and intracellular accumulation of abnormal proteins in the form of protein inclusions and aggregates occur in almost all tissues of an aged organism. Preservation or enhancement of the activity of these surveillance systems until late in life improves their resistance to stress and is sufficient to slow down aging. In this work, we review recent advances on our understanding of the contribution of chaperones and proteolytic systems to the maintenance of cellular homeostasis, the cellular response to stress and ultimately to longevity. © 2010 Elsevier B.V.
Outcome instruments to measure frailty: A systematic reviewN. M. de Vries | J. B. Staal | C. D. van Ravensberg | J. S M Hobbelen | M. G M Olde Rikkert | M. W G Nijhuis-van der Sanden
Volume 10, Issue 1, January 2011, Pages 104-114
Frailty is one of the greatest challenges for healthcare professionals. The level of frailty depends on several interrelated factors and can change over time while different interventions seem to be able to influence the level of frailty. Therefore, an outcome instrument to measure frailty with sound clinimetric properties is needed. A systematic review on evaluative measures of frailty was performed in the databases PubMed, EMBASE, Cinahl and Cochrane. The results show numerous instruments that measure the level of frailty. This article gives a clear overview of the content of these frailty instruments and describes their clinimetric properties. Frailty instruments, however, are often developed as prognostic instruments and have also been validated as such. The clinimetric properties of these instruments as evaluative outcome measures are unclear. © 2010 Elsevier B.V.
Tau protein kinases: Involvement in Alzheimer's diseaseLudovic Martin | Xenia Latypova | Cornelia M. Wilson | Amandine Magnaudeix | Marie Laure Perrin | Catherine Yardin | Faraj Terro
Volume 12, Issue 1, January 2013, Pages 289-309
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby might contribute to tau aggregation. Thus, understanding the regulation modes of tau phosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates in order to elaborate protection strategies to cope with these lesions in Alzheimer's disease. Among the possible and specific interventions that reverse tau phosphorylation is the inhibition of certain tau kinases. Here, we extensively reviewed tau protein kinases, their physiological roles and regulation, their involvement in tau phosphorylation and their relevance to AD. We also reviewed the most common inhibitory compounds acting on each tau kinase. © 2012 Elsevier B.V.
Systematic review and meta-analysis of the effects of high protein oral nutritional supplementsA. L. Cawood | M. Elia | R. J. Stratton
Volume 11, Issue 2, April 2012, Pages 278-296
Disease-related malnutrition is common, detrimentally affecting the patient and healthcare economy. Although use of high protein oral nutritional supplements (ONS) has been recommended to counteract the catabolic effects of disease and to facilitate recovery from illness, there is a lack of systematically obtained evidence to support these recommendations. This systematic review involving 36 randomised controlled trials (RCT) (n=3790) (mean age 74. years; 83% of trials in patients >65. years) and a series of meta-analyses of high protein ONS (>20% energy from protein) demonstrated a range of effects across settings and patient groups in favour of the high protein ONS group. These included reduced complications (odds ratio (OR) 0.68 (95%CI 0.55-0.83), p<. 0.001, 10 RCT, n=. 1830); reduced readmissions to hospital (OR 0.59 (95%CI 0.41-0.84), p=. 0.004, 2 RCT, n=. 546); improved grip strength (1.76. kg (95%CI 0.36-3.17), p<. 0.014, 4 RCT, n=. 219); increased intake of protein (p<0.001) and energy (p<0.001) with little reduction in normal food intake and improvements in weight (. p<. 0.001). There was inadequate information to compare standard ONS (<20% energy from protein) with high protein ONS (>20% energy from protein). The systematic review and meta-analysis provides evidence that high protein supplements produce clinical benefits, with economic implications. © 2011 Elsevier B.V.
Influenza vaccine responses in older adultsJanet E. McElhaney
Volume 10, Issue 3, July 2011, Pages 379-388
The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults. © 2010 Elsevier B.V.
Association of frailty with survival: A systematic literature reviewTatyana Shamliyan | Kristine M C Talley | Rema Ramakrishnan | Robert L. Kane
Volume 12, Issue 2, March 2013, Pages 719-736
Frailty is a known risk factor for those aged 65 and over, and its prevalence increases with age. Definitions of frailty vary widely, and prevalence estimates are affected by the way frailty is defined. Systematic reviews have yet to examine the literature on the association between definitions of frailty and mortality. We examined the definitions and prevalence of frailty and its association with survival in older community-dwelling adults. We conducted a systematic review of observational population-based studies published in English. We calculated pooled prevalence of frailty with a random effects model. We identified 24 population-based studies that examined frailty in community-dwelling older adults. The pooled prevalence was 14% when frailty was defined as a phenotype exhibiting three or more of the following: weight loss, fatigue/exhaustion, weakness, low physical activity/slowness, and mobility impairment. The pooled prevalence was 24% when frailty was defined by accumulation of deficits indices that included up to 75 diseases and impairments. The prevalence of frailty increased with age and was greater in women and in African Americans. Frailty in older adults was associated with poor survival with a dose-responsive reduction in survival per increasing number of frailty criteria. Taking into account population prevalence and multivariate adjusted relative risks, we estimated that 3-5% of deaths among older adults could be delayed if frailty was prevented. Frailty is a prevalent and important geriatric syndrome associated with decreased survival. Geriatric assessment of frailty provides clinically important information about functional status and survival of older adults. © 2012 Elsevier B.V.
Age effects on B cells and humoral immunity in humansDaniela Frasca | Alain Diaz | Maria Romero | Ana Marie Landin | Bonnie B. Blomberg
Volume 10, Issue 3, July 2011, Pages 330-335
Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging. © 2010 Elsevier B.V.
Frailty and cognitive impairment-A review of the evidence and causal mechanismsDeirdre A. Robertson | George M. Savva | Rose Anne Kenny
Volume 12, Issue 4, September 2013, Pages 840-851
Incidence rates of cognitive impairment and dementia are rising with the ageing population. Meanwhile, the limited success of current treatments has led to a search for early markers of dementia which could predict future progression or improve quality of life for those already suffering from the disease. One focus has been on the correlation between physical and cognitive measures with an increasing interest in the association between frailty and cognitive decline. Frailty is an age-related syndrome described as the decreased ability of an organism to respond to stressors. A number of epidemiological studies have reported that frailty increases the risk of future cognitive decline and that cognitive impairment increases the risk of frailty suggesting that cognition and frailty interact within a cycle of decline associated with ageing. This paper reviews the evidence for an association between frailty and cognitive impairment and outlines some of the mechanisms that potentially underpin this relationship from brain neuropathology and hormonal dysregulation to cardiovascular risk and psychological factors. © 2013 Elsevier B.V.
Senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontologyDaniel H. Nussey | Hannah Froy | Jean François Lemaitre | Jean Michel Gaillard | Steve N. Austad
Volume 12, Issue 1, January 2013, Pages 214-225
That senescence is rarely, if ever, observed in natural populations is an oft-quoted fallacy within bio-gerontology. We identify the roots of this fallacy in the otherwise seminal works of Medawar and Comfort, and explain that under antagonistic pleiotropy or disposable soma explanations for the evolution of senescence there is no reason why senescence cannot evolve to be manifest within the life expectancies of wild organisms. The recent emergence of long-term field studies presents irrefutable evidence that senescence is commonly detected in nature. We found such evidence in 175 different animal species from 340 separate studies. Although the bulk of this evidence comes from birds and mammals, we also found evidence for senescence in other vertebrates and insects. We describe how high-quality longitudinal field data allow us to test evolutionary explanations for differences in senescence between the sexes and among traits and individuals. Recent studies indicate that genes, prior environment and investment in growth and reproduction influence aging rates in the wild. We argue that - with the fallacy that wild animals do not senesce finally dead and buried - collaborations between bio-gerontologists and field biologists can begin to test the ecological generality of purportedly 'public' mechanisms regulating aging in laboratory models. © 2012 Elsevier B.V.
Impact of cellular senescence signature on ageing researchEwa Sikora | Thomas Arendt | Martin Bennett | Masashi Narita
Volume 10, Issue 1, January 2011, Pages 146-152
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to the associated secretory phenotype senescence can also contribute to cancer and possibly other age-related diseases, such as obesity, diabetes, atherosclerosis and Alzheimer's disease. There are two major mechanisms of cellular senescence; replicative senescence depends on telomere erosion or dysfunction whilst stress-induced premature senescence (SIPS) is telomere-independent and also includes oncogene-induced senescence (OIS). The senescence phenotype is characterised by altered cellular morphology, increased activity for senescence-associated-β-galactosidase (SA-β-GAL), increased formation of senescence-associated heterochromatin foci (SAHF) and promyelocytic leukemia protein nuclear bodies (PML NBs), permanent DNA damage, chromosomal instability and an inflammatory secretome. Some of these markers have been identified in cells from age-related pathologies. However, to improve our understanding of the contribution of cellular senescence to organismal ageing and age-related disease, it is imperative to define an unequivocal signature of cellular senescence that is functionally connected with normal and pathological ageing. Herein, we describe the processes leading to senescence, and the current biomarkers of cellular senescence, with particular emphasis on the causal role of DNA damage responses involved in the process. We highlight the gaps in our knowledge both of the processes leading to senescence, and the signature of cellular senescence both in vitro and in vivo. A well-defined set of senescence biomarkers for ageing and age-related disease would have a strong impact on the diagnosis, staging and predicted outcomes of age-related disease, providing the basis for a pharmacological intervention to postpone ageing and age-related disease. © 2010 Elsevier B.V.
Dysregulation of human Toll-like receptor function in agingAlbert C. Shaw | Alexander Panda | Samit R. Joshi | Feng Qian | Heather G. Allore | Ruth R. Montgomery
Volume 10, Issue 3, July 2011, Pages 346-353
Studies addressing immunosenescence in the immune system have expanded to focus on the innate as well as the adaptive responses. In particular, aging results in alterations in the function of Toll-like receptors (TLRs), the first described pattern recognition receptor family of the innate immune system. Recent studies have begun to elucidate the consequences of aging on TLR function in human cohorts and add to existing findings performed in animal models. In general, these studies show that human TLR function is impaired in the context of aging, and in addition there is evidence for inappropriate persistence of TLR activation in specific systems. These findings are consistent with an overarching theme of age-associated dysregulation of TLR signaling that likely contributes to the increased morbidity and mortality from infectious diseases found in geriatric patients. © 2010 Elsevier B.V.
Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: A meta-analysisN. M. de Vries | C. D. van Ravensberg | J. S M Hobbelen | M. G M Olde Rikkert | J. B. Staal | M. W G Nijhuis-van der Sanden
Volume 11, Issue 1, January 2012, Pages 136-149
This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was performed in the databases PubMed, CINAHL, Embase, PEDro and The Cochrane Library. Relevant study characteristics were reviewed and meta-analyses using standardized mean differences (SMDs) were performed. The results show that physical exercise therapy has a positive effect on mobility (SMD final value: 0.18; 95% CI: 0.05, 0.30; SMD change value: 0.82; 95% CI: 0.54, 1.10) and physical functioning (SMD final value: 0.27; 95% CI: 0.08, 0.46; SMD change value: 2.93; 95% CI: 2.50, 3.36). High-intensity exercise interventions seem to be somewhat more effective in improving physical functioning than low-intensity exercise interventions (SMD final value: 0.22; 95% CI: -0.17, 0.62; SMD change value: 0.38; 95% CI: -0.48, 1.25). These positive effects are of great value for older adults who are already physically impaired. The effect on physical activity and quality of life was not evident and no definite conclusions on the most effective type of physical exercise therapy intervention can be drawn. © 2011 Elsevier B.V.
Cognitive intervention for persons with mild cognitive impairment: A meta-analysisHuijie Li | Juan Li | Nanxin Li | Bing Li | Pengyun Wang | Ting Zhou
Volume 10, Issue 2, April 2011, Pages 285-296
Cognitive training for persons with mild cognitive impairment (MCI) has become a hot topic. However to date it remains controversial whether persons with MCI can really benefit from cognitive intervention. We aim to further investigate this by using meta-analysis of seventeen clinical studies of cognitive intervention for MCI. The results demonstrate that after training, patients with MCI improve significantly both in overall cognition and overall self-ratings. Specifically, persons with MCI obtain moderate benefits in language, self-rated anxiety and functional ability, and receive mild benefits in episodic memory, semantic memory, executive functioning/working memory, visuo-spatial ability, attention/processing speed, MMSE, self-rated memory problem, quality of life, activities of daily life and self-rated depression. The results also suggest that persons with MCI benefit from the cognitive intervention in the follow-up data. The present meta-analysis demonstrates that cognitive intervention can be a potential efficient method to enhance cognitive and functional abilities in persons with MCI, although the improvements may be domain-specific. © 2010 Elsevier B.V.
A systematic review of leukocyte telomere length and age in adultsAysel Müezzinler | Aida Karina Zaineddin | Hermann Brenner
Volume 12, Issue 2, March 2013, Pages 509-519
Objective: To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults. Methods: Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients. Results: Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r= -0.338, p<. 0.0001) and relative LTL (r= -0.295, p= 0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91. BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5. BP/year). Conclusion: While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse. © 2013 Elsevier B.V.
Persistent viral infections and immune agingStefan Brunner | Dietmar Herndler-Brandstetter | Birgit Weinberger | Beatrix Grubeck-Loebenstein
Volume 10, Issue 3, July 2011, Pages 362-369
Immunosenescence comprises a set of dynamic changes occurring to both, the innate as well as the adaptive immune system that accompany human aging and result in complex manifestations of still poorly defined deficiencies in the elderly population. One of the most prominent alterations during aging is the continuous involution of the thymus gland which is almost complete by the age of 50. Consequently, the output of naïve T cells is greatly diminished in elderly individuals which puts pressure on homeostatic forces to maintain a steady T cell pool for most of adulthood. In a great proportion of the human population, this fragile balance is challenged by persistent viral infections, especially Cytomegalovirus (CMV), that oblige certain T cell clones to monoclonally expand repeatedly over a lifetime which then occupy space within the T cell pool. Eventually, these inflated memory T cell clones become exhausted and their extensive accumulation accelerates the age-dependent decline of the diversity of the T cell pool. As a consequence, infectious diseases are more frequent and severe in elderly persons and immunological protection following vaccination is reduced. This review therefore aims to shed light on how various types of persistent viral infections, especially CMV, influence the aging of the immune system and highlight potential measures to prevent the age-related decline in immune function. © 2010 Elsevier B.V.
MSCs: Biological characteristics, clinical applications and their outstanding concernsYi Ling Si | Ya Li Zhao | Hao Jie Hao | Xiao Bing Fu | Wei Dong Han
Volume 10, Issue 1, January 2011, Pages 93-103
Mesenchymal stem cells (MSCs) are multi-potent adult stem cells harboring multi-lineage differentiation potential and immunosuppressive properties that make MSCs an ideal candidate cell type for immunomodulation and regenerative medicine. Currently, MSC-related researches and clinical trials have evoked exciting promise in a variety of disorders and tissue regeneration. However, it must be recognized that several critical potential problems have also emerged from current clinical trials, for example: (1) the indefinite association between the phenotypic characteristics and the biological functions of MSCs; (2) the lack of clinical data to support the long-term safety of MSCs; (3) the need for further clarification of multiple mechanisms of MSC transplant actions in vivo; and (4) the lack of comparability of MSC transplant efficacy. Therefore, MSC-based therapies could not yet be considered a routine treatment in the clinic. Based on these, we proposed that large-scale and multi-center clinical trials of MSC-based therapies should be initiated under strict supervision. These interventions might help to establish a new clinical paradigm to turn MSC transplantation into a routine therapy for at least some diseases in the near future. © 2010 Elsevier B.V.
Of mice and men: The benefits of caloric restriction, exercise, and mimeticsEvi M. Mercken | Bethany A. Carboneau | Susan M. Krzysik-Walker | Rafael De Cabo
Volume 11, Issue 3, July 2012, Pages 390-398
During aging there is an increasing imbalance of energy intake and expenditure resulting in obesity, frailty, and metabolic disorders. For decades, research has shown that caloric restriction (CR) and exercise can postpone detrimental aspects of aging. These two interventions invoke a similar physiological signature involving pathways associated with stress responses and mitochondrial homeostasis. Nonetheless, CR is able to delay aging processes that result in an increase of both mean and maximum lifespan, whereas exercise primarily increases healthspan. Due to the strict dietary regime necessary to achieve the beneficial effects of CR, most studies to date have focused on rodents and non-human primates. As a consequence, there is vast interest in the development of compounds such as resveratrol, metformin and rapamycin that would activate the same metabolic- and stress-response pathways induced by these interventions without actually restricting caloric intake. Therefore the scope of this review is to (. i) describe the benefits of CR and exercise in healthy individuals, (. ii) discuss the role of these interventions in the diseased state, and (. iii) examine some of the promising pharmacological alternatives such as CR- and exercise-mimetics. © 2011 .
Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespanWilliam R. Swindell
Volume 11, Issue 2, April 2012, Pages 254-270
Laboratory survival experiments have shown that dietary restriction (DR) can increase median and maximum lifespan. This paper provides a meta-analysis of laboratory experiments that have evaluated the effects of DR on lifespan in rats and mice (1934-present). In rats, DR increased median lifespan by 14-45% in half of all experiments, but in mice the effects of DR have been much weaker (4-27%). The least favorable effects of DR on lifespan have been observed among inbred rather than non-inbred mouse strains. In fact, some inbred mouse strains do not necessarily live longer with DR, including DBA/2 male mice and several strains from the ILSXISS recombinant inbred panel. Shortening of lifespan with DR has also been observed and confirmed for ILSXISS strain 114. Importantly, all rodent studies may be biased by the effects of laboratory breeding, since one study has shown that median lifespan is not improved by DR in wild-derived mice. These findings suggest that the set of genetic backgrounds studied in rodent DR experiments should be diversified. This will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species. © 2011 Elsevier B.V.
Cognitive interventions in healthy older adults and people with mild cognitive impairment: A systematic reviewJennifer Reijnders | Caroline van Heugten | Martin van Boxtel
Volume 12, Issue 1, January 2013, Pages 263-275
Given that the research area of cognitive intervention studies in the aging population is growing rapidly, it is important to review and gauge more recent intervention studies, in order to determine the evidence for the effectiveness of cognitive interventions. The purpose of the present review was to update the recent systematic reviews of Papp et al. (2009) and Martin et al. (2011), to evaluate the effectiveness of cognitive interventions in healthy older adults and people with MCI, by taking into account the methodological quality of the interventions studies. A systematic review of randomized controlled trials (RCT) and clinical studies published between August 2007 and February 2012 in Pubmed and PsychINFO was performed. The quality of the included RCTs was assessed according to the CONSORT criteria for RCTs. A total of thirty-five studies were included; twenty-seven RTCs and eight clinical studies. The content of the intervention studies differed widely, as did the methodological quality of the included RCTs, but was considerably low with an average of 44% of the Consort items included. The results show evidence that cognitive training can be effective in improving various aspects of objective cognitive functioning; memory performance, executive functioning, processing speed, attention, fluid intelligence, and subjective cognitive performance. However, the issue whether the effects of cognitive interventions generalize to improvement in everyday life activities is still unresolved and needs to be addressed more explicitly in future research. © 2012 Elsevier B.V.
TOR signaling never gets old: Aging, longevity and TORC1 activityDaniel S. Evans | Pankaj Kapahi | Wen Chi Hsueh | Lutz Kockel
Volume 10, Issue 2, April 2011, Pages 225-237
The target of rapamycin (TOR) signal transduction network monitors intra- and extracellular conditions that favor cell growth. Research during the last decade has revealed a modular structure of the TOR signaling network. Each signaling module senses a particular set of signals from the cellular milieu and exerts regulatory control towards TOR activity. The TOR pathway responds to growth factor signals, nutrient availability, and cellular stresses like hypoxia and energy stress. The signaling modules and their molecular components constituting the TOR network are remarkably conserved in both sequence and function across species. In yeast, roundworms, flies, and mice, the TOR pathway has been shown to regulate lifespan. Correspondingly, genetic, dietary or pharmacological manipulation of individual signaling modules as well as TOR activity itself extends lifespan in these model organisms. We discuss the potential impact of manipulating TOR activity for human health and lifespan. © 2010 Elsevier B.V.
Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?Sónia C. Correia | Renato X. Santos | George Perry | Xiongwei Zhu | Paula I. IMoreira | Mark A. Smith
Volume 10, Issue 2, April 2011, Pages 264-273
Severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic Alzheimer's disease (sAD) pathology. Indeed, the " insulin-resistant brain state" has been hypothesized to form the core of the neurodegenerative events that occur in sAD. In this vein, intracerebroventricular administration of subdiabetogenic doses of streptozotocin (STZ) in rats can induce an insulin-resistant brain state, which is proposed as a suitable experimental model of sAD. This review highlights the involvement of disturbed brain insulin metabolism in sAD etiopathogenesis. Furthermore, current knowledge demonstrates that central STZ administration produces brain pathology and behavioral changes that resemble changes found in sAD patients. The STZ-intracerebroventricularly treated rat represents a promising experimental tool in this field by providing new insights concerning early brain alterations in sAD, which can be translated in novel etiopathogenic and therapeutic approaches in this disease. © 2011 Elsevier B.V.


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This review is from: ASUS VS Series VS198D-P Black 19" 5ms LED Backlight Widescreen LCD Monitor 250 cd/m2 ASCR 50000000:1
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Apartments in Budapest in downtown, all new restructuring. Furnished with glamour, for your holiday or your period of study in Budapest. These are just some of our apartments. If the apartment in Budapest you like isn't available, we will offer another one with the same characteristics of quality, price and location!
1) Find your apartment
Put the dates of arrival, departure and the total number of guests. Please, Click on "Search"
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The system will show you all the available apartments for the selected dates. You can see the details on "information". Once you have chosen the apartment please click on "Book"
3) Book it!
Please check once again that the dates are exact. Please put the number of the guests with more than 11 years: children dont'pay! Please, select the Extra services, the cost is automatically charged on the total amount. Please complete all the fields. Now click on "Book"
4) Confirm the reservation
Please pay 20% of the total amount as deposit, through PayPal! it is a secure system and it allows you to use your Credit card, without registration
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You will receive the confirmation of your booking and information about the delivery of the keys via email. We want to know your schedule of arrival!
6) Delivery of the keys
Our staff will wait you at the apartment in order to give you the keys. You could pay there the rest of your booking.
Our office, located in József Nádor Tér 9 - 1051 Budapest, will always be your reference point during your stay in Budapest.
On arrival a representative of our staff will deliver the keys and show you all the details and will give you all the information you need regarding your apartment.
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We visited Budapest in July for a stag do and stayed at the apartment in Vaci 25. The street has everything you need in bars and restaurants and is very central. The apartment itself was very modern and had recently been redecorated. All in all the service we received was amazing and when we next visit Budapest I would most definitely stay in the same apartment.
The location was EXCELLENT, next to the best ruin pubs, a supermarket and a metro station. We had a really good time at Budapest
Dear friends, our stay in Budapest was awesome - the accommodation was great - super location, nice, neat and good price. We were able to visit everything we plan. I recommend this apartment to everyone, who wants to experience the beauty of city centre of Budapest.
Thanks Darina
I and my family really enjoy our staying in the apartment on Regiposta Utica. It was spacious. It was close to everything. We thank you very much. We enjoy the staff, particularly this gentleman who checked us out. We would like to go again to Budapest and stay in the same place.
Woodly Dormeus
We had a great time in Budapest, a beautiful city full of impressive
buildings and a good nightlife.
We stayed in Budapest with a group of 20 persons without any problems.
Our appartments were very decent, right in the centre and had all
facilities we wanted.
I strongly recommend budapest and the appartments to people who are
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We enjoyed our stay very much. The location of the appartment was great,
near the subwaystation and in the center of town. To be honest: the only thing we did at the appartment was sleep. We weren't there much
The best location.
Apartment in a great location. Food shop in the same building, to the metro station 7 minutes walk, 10 minutes to the Danube boulevards and to great of places for morning coffee or an evening drink in Bálna (CET-Shopping and
Cultural Centre). Ráday street is full of nice pubs with good food. On Gellért hill from the apartment you can walk in 30 minutes. A very large apartment in a quiet townhouse, perfect for 9 people. Two large rooms, one smaller one for two people. Equipment satisfactory.
I fell in love with Budapest and next time also will choose
Greetings from Poland and I'll see you soon :)
Excellent apartment.
We really enjoyed our apartment in Regiposta utca 9-11. It was right in
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recommend that place to all our friends. Thanks
The location of our apartment could not have been better. We were steps away from the Chain Bridge, St Stephen's, restaurants, metro. The apartment was in a beautiful building. The staff that greeted us was friending, helpful, and quick to check us in. We had traveled by overnight train so being able to go straight to the apartment before check-in time was very nice.
It was nine of us during our stay in Raday ut 32 and I have to say that the apartment really suited the needs of all of us. Great location, helpfull staff and amenities that made our stay comfortable. All in all a great weekend in Budapest!
Warm recommendation to everyone coming to Budapest.
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The Real Estate Offer of Budapest Apartments Holiday provides apartments in Budapest in historical buildings located in the main district of the city. This is, in fact, the most valuable area for the Real Estate revaluation. We help our investors with the management of: investment, bureaucracy ,administration of the Real Estate, purchase permits. With the professional skills that we provide, we guarantee you a good investment!
Budapest Apartments Holiday provides useful support such as: Project, Furniture, Renovation
Budapest Apartments Holiday will establish contacts with the best international banks of Budapest in order to obtain customized funding of up to 50 % of the Real Estate Value.
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Budapest Apartments Holiday rents out your property and provides the management for short, mid or long term rentals. Hence, when renting out your flat you could recoup the costs of your funding!
The Budapest apartments are equipped with every comfort, digital TV, home appliances, kitchen flatware, Internet 24 hours. Upon arrival the apartment will be heated and a member of our staff is waiting for you and will give you all the info you need for the flat. We offer, in addition, the taxi service from/to airport, box auto, key service delivery 24h and luggage deposit in our office.
L'Budapest Apartments Holiday every study-season accommodates Erasmus students in a dedicated line of apartments. The experience gained during the years allows us to offer a great service aimed to the student needs. The wide rooms are of different kind, single and double rooms with cupboards and desks. Internet 24 hours with fiber optic connections and WiFi, digital TV. Taxi transfer from/to airport. All the apartments for study are close to the main universities
30 December 2016: Gala Concert of the 100 - Member...
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see all tour...
Our office will suggest you the best places to eat and have fun. The Budapest Apartments Holiday, in addition to the beauty and comfort of the accommodations, also offer a reception service at 360 °, before, during, and after your stay!
Come to discover the Rudas thermal baths of the sixteenth century. Just reopened after a major restoration - These are just some of Spas in Budapest. Breath the air of your home sleeping in our apartments, enjoy the relax and the benefits of the wonderful Spa of the Capital
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text:
What's Buried in the Fine Print? Tell the CFPB to Protect Consumers from Forced Arbitration!
Be sure to check out the full version of the December issue of the Let America Know newsletter.
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text:
Just curious. I love girls (as long as they are skinny), but vaginas turn me off. I need to focus on t*ts/ass/legs to get hard...
Most Helpful Girl
I think vaginas are ugly, but looks aren't everything I guess.10|10|0
Just curious. I love girls (as long as they are skinny), but vaginas turn me off. I need to focus on t*ts/ass/legs to get hard...
I think vaginas are ugly, but looks aren't everything I guess.
To each their own... and I suspect this is a troll. But let me tell you, if my boyfriend said that to me, our physical relationship would be over. And probably the rest of our relationship too.
If it's just not that much of a turn on for you, that's one thing. But if it's actually a turn OFF for you? I like my vagina and if someone else doesn't, I guess they don't need to be sticking their own genitals into it.
Whatever you say.
stop talking to me. you're done here.
idk I think a lot of guys are like that
its interesting. I'm bi and I don't think as many homosexual girls feel that way as do heterosexual guys. hmm...
anyway I love pussy, I think its beautiful and I love going down on girls. yum. P:
hehe I'm such a homo
and I like non-skinny girls so there's another thing we don't have in common lol
i have girl friends who love guys but think penises look gross though so maybe some people just don't like genitalia. my best friend is like that, she refuses to give blow jobs because she thinks its gross and she doesn't want a penis in her face.
"so maybe some people just don't like genitalia."
Wow, you're weird.
Where else would you like to put your P then? *cough* :P
I like to put my d*** in it, but I don't like how it looks. There's a difference. Is it really that difficult to understand?
yes it is, cause you know it's ugly and a turn off for you, but you would like to put your d***y in there.. it's paradox.
But I think your not the only one.
Well I like em, I love em, I want some more of em
I think you are probably in the closet. You don't really like a woman's figure, they have to be skinny like a boy in order for you to look at them.
oh this reason for thinks vaginas look disgusting your thinking is wright from your sight
I don't think they're disgusting but they're not much of a turn on for me. I need to focus on the others like you said.
You cannot undo this action. The opinion owner is going to be notified and earn 7 XPER points.


text:
dual head cardA type of dual monitor system in which a single video card uses a single chipset to drive two display devices at the same time on one system. The technology was pioneered by Matrox Graphics Inc., with the technology first appearing in the Matrox G400 line of graphics cards in 1999. DualHead is sometimes spelled dual-head.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
Webopedia's student apps roundup will help you to better organize your class schedule and stay on top of assignments and homework. Read More »List of Free Shorten URL Services
A URL shortener is a way to make a long Web address shorter. Try this list of free services. Read More »Top 10 Tech Terms of 2015
The most popular Webopedia definitions of 2015. Read More »
Java is a high-level programming language. This guide describes the basics of Java, providing an overview of syntax, variables, data types and... Read More »Java Basics, Part 2
This second Study Guide describes the basics of Java, providing an overview of operators, modifiers and control Structures. Read More »The 7 Layers of the OSI Model
The Open System Interconnection (OSI) model defines a networking framework to implement protocols in seven layers. Use this handy guide to compare... Read More »


text: View Full Chapter Figures Only Tables Only Videos Only Print Share Email Send Email Your Name (required) Example: John Doe Email Address (required) Please enter a valid sender email address. Example: firstname.lastname@example.com CC Me Recipient Email Address (required) Separate multiple email address with semi-colons (up to 5). Subject Subject for your email. Message (Maximum characters: 1,000) Send Cancel Copyright Paragraph Text Copyright Line Text Get Citation Citation Journal name Download citation file: RIS (Zotero) EndNote BibTex Medlars ProCite RefWorks Reference Manager © Copyright Tools Search Book Top Return Clip Search Book Chapter 64. Occlusive Arterial Disease Anil Chopra; David Carr ++ Acute limb ischemia secondary to thrombosis or embolism is a true medical emergency requiring immediate therapy for limb salvage. The term critical limb ischemia is used when chronic progressive peripheral arterial disease results in ischemic pain at rest, ulceration, or gangrene. Despite improvements in the management of peripheral arterial disease, current 1-year mortality after the onset of critical limb ischemia is in excess of 25%, and 25% of survivors require amputation.1,2 Diagnosis of acute limb ischemia is based primarily on findings of a detailed history and physical examination. Upon diagnosis, urgent involvement of both the radiologist and vascular surgeon is required in order to confirm the diagnosis and initiate treatment to restore blood flow to the affected limb. For a rapid and reliable diagnosis, a thorough understanding of the pathophysiology, etiology, and clinical presentation of occlusive arterial disease is required and can help guide management decisions. ++ According to the National Health and Nutrition Examination Survey (NHANES) data for 1999 to 2000, the prevalence of peripheral arterial disease (defined as an ankle-brachial index of <0.9) in the U.S. is 4.3% for those aged >40 years and 15.5% for those aged >70 years.3 The Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival (PARTNERS) study assessed the prevalence of occlusive arterial disease in high-risk populations—those aged >70 years and those aged >50 years with diabetes or a smoking history—and found the prevalence to be >29%.4 ++ With objective noninvasive testing, peripheral arterial disease has been reported in 11% to 27% of elderly men and women, with both sexes affected equally.5 ++ Symptoms of this disease increase with age and are two to four times more common in men than in women. Most of these patients have a long history of smoking, and it has been reported that >80% of patients with occlusive arterial disease are either former or current smokers.6 Other risk factors include diabetes, hyperlipidemia, hypertension, hyperhomocysteinemia, and an elevated C-reactive protein level. Of all the known risk factors for occlusive arterial disease, smoking and diabetes are pathophysiologically the most important. Between 40% and 60% of patients with occlusive arterial disease have either coronary or cerebrovascular disease.7 The severity of peripheral vascular disease is closely linked to the risk of myocardial infarction, ischemic stroke, and death from vascular disease.5 The most frequently diseased arteries leading to limb ischemia are, in order of occurrence, the femoropopliteal, tibial, aortoiliac, and brachiocephalic vessels. ++ Acute limb ischemia results from a lack of blood supply to meet tissue oxygen and nutrient requirements. As time proceeds, the depletion of oxygen and nutrients from the cellular microenvironment will ultimately lead to cell death and irreversible tissue damage. Peripheral nerves and skeletal muscle are more sensitive to ischemia, and irreversible changes occur in these tissues within 6 hours of anoxia at room temperature, likely due to differences in cellular respiration and oxygen requirements. ++ Upon reperfusion from complete or partial restoration of the blood ... Log In to View MoreIf you don't have a subscription, please view our individual subscription options below to find out how you can gain access to this content. MyAccess Sign In Username Password Forgot Password? Forgot Username? Create a MyAccess Profile Want remote access to your institution's subscription? Sign in via OpenAthens Sign in via Shibboleth Want remote access to your institution's subscription? 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Ok Subscription Options AccessMedicine Full Site: One-Year Subscription Connect to the full suite of AccessMedicine content and resources including more than 250 examination and procedural videos, patient safety modules, an extensive drug database, Q&A, Case Files, and more. $995 USD Buy Now Pay Per View: Timed Access to all of AccessMedicine 24 Hour Subscription $34.95 Buy Now 48 Hour Subscription $54.95 Buy Now


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"John Ware has been suspended from school," said O'Brien. "He's academically suspended. He's suspended. That doesn't mean he's out. He has to clear up some things academically, and he's going to come back."
A redshirt sophomore, NC State moved Ware to safety from outside linebacker prior to spring practice, but early in fall practice he was back at linebacker.
Very instinctive and athletic, he tallied 20 tackles, 1.5 tackles for a loss, and a forced fumble during his redshirt freshman campaign, mainly playing on special teams and on obvious passing downs.
The 5-foot-11, 205 pounder was expected to battle for playing time at linebacker, but it may have been an uphill battle. Nate Irving, Ray Michel, and Robbie Leonard are listed as the starters, and sophomore Thomas Barnes is in the mix as well as freshmen Audie Cole, Dwayne Maddox, Sterling Lucas, and William Beasley.
A native of Fort Lauderdale, Florida, Ware was not present this weekend for the Wolfpack's Media Day.


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Scouts, Muhls excited for District quarterfinals
Conrad Weiser and Muhlenberg have a chance to meet in the District III-AAA semifinals. But first, the Scouts and Muhls have to get through challenging quarterfinal games.
4th-seeded Conrad Weiser hosts 5-seed Dover on Friday night. Its the Scouts' second consecutive home District game. They rolled over Spring Grove, 24-0, in their opener.
Dover is expected to feature quick scatbacks, an offensive dimension that has given the Scouts some trouble this year. But Weiser has the size advantage, something that they feel can neutralize the speed threat.
Muhlenberg faces a stiffer challenge in its quarterfinal game. The Muhls travel to top-seeded Bishop McDevitt to take on the Crusaders at brand-new Rocco Ortenzio Stadium.
Muhlenberg physically dominated Shippensburg in their opener, 49-19, something the Muhls feel they can do to McDevitt. The Crusaders are a relatively young team. The Muhls are an older, physical team and they feel they can dominate that aspect of the game.
So long as Muhlenberg minimizes the big-play potential of McDevitt, the Muhls feel like they have a chance.
Copyright 2013 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text: Situated on a stretch of beach in Buzios Chez Pitu Praia Hotel is within easy reach of Geriba Beach Geriba Lagoon and Chapel of Our Lady Desatanudos. Also nearby are Manguinhos Beach and Tucuns Beach. The 35 air-conditioned guestrooms at Chez Pitu Praia Hotel include laptop-compatible safes and minibars. Beds have pillowtop mattresses and down comforters. Complimentary wireless high-speed Internet access is provided. Televisions are equipped with premium cable channels. Bathrooms offer showers and hair dryers. Additional amenities include safes and complimentary newspapers. Housekeeping is offered daily. Sit back and relax on the beach with complimentary cabanas umbrellas and sun loungers. After a day at the beach enjoy amenities at Chez Pitu Praia Hotel like an outdoor pool and a sauna. Wireless and wired high-speed Internet access is complimentary in public areas. Onsite parking is complimentary.


text: After experiencing severe bullying in middle school, Claire became passionate to change the mindset of youth. She created an inspirational program, PROJECT CLAIRE BEAR, which has aided hundreds of children in learning to overcome their challenges. Claire is a senior at Eastside Catholic High School, where she is a National Honor Society member and leader. She plans to obtain her Bachelor of Arts degree in Communications and become a broadcast journalist for a major network.


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Discussion in 'Pistons and NBA' started by round, Mar 3, 2011.
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Man issued 2 summonses after bringing gun to RIC
A Disputanta, Va. man was cited at Richmond International Airport Oct. 8 after it was discovered that he had a .25-caliber handgun in his carry-on bag. TSA officers detected the gun as the man's carry-on baggage passed through the checkpoint metal detector.
TSA officials contacted the Capital Regional Airport Commission Police, who regularly patrol the airport. The police responded, confiscated the weapon and issued two summonses to the man related to state weapons charges. There was no impact to airport operations. The man, who was ticketed to fly to Atlanta, was able to continue on his flight.
Some weapons are permitted to be transported in checked baggage if properly packaged, but passengers should check with the airlines for proper procedures as well as checking into local laws before doing so.
Passengers can review the prohibited items list on the TSA homepage or they can download the free MyTSA application from the TSA homepage. The TSA web site and the MyTSA app have a "Can I Bring?" feature that allows users to type in items they plan to bring on a trip to get an explanation of TSA's security policies for the item, including whether the item can be taken in carry-on luggage through the security checkpoint, packed in checked baggage, both, or neither. The mobile app is available to download for free at http://www.tsa.gov/mobile.
Reynolds CC to host sculptor Paul DiPasquale
Reynolds Community College will host Richmond sculptor Paul DiPasquale Sept. 28 as he shares his presentation "Art Talk, Why Art Matters" from 6 p.m. to 8 p.m. in the Conference Center Gallery of the Workforce Development and Conference Center on the Parham Road Campus, located at 1651 E. Parham Road in Richmond. This event is free and open to the public. > Read more.
Free children's clothing for those in need
The Children's Clothing Closet at Highland Springs United Methodist Church will be open Saturday, Aug. 27 and Tuesday, Aug. 30 to provide free new or nearly new children's clothing for families in need, prior to the start of the school year. The Clothing Closet will be open from 10 a.m. to noon both days. The church is located at 22 North Holly Avenue. > Read more.
Weekend Top 10
Beautiful fall weather is back this weekend! Don't leave your favorite pooch at home – take the whole family to Canine Companions' DogFest Walk 'n Roll at West Broad Village or FETCH a Cure's annual Mutt Strutt at Deep Run Park. Pets are also welcome at this weekend's Central Virginia Celtic Festival and Highland Games. Halloween events taking place Sunday include the University of Richmond's 18th annual Trick or Treat Street and Goblins and Gourds at Lewis Ginter Botanical Garden. For all our top picks this weekend, click here! > Read more.
Business in brief
Henrico Police seek robbery suspect
Rabid skunk sprays dog in Eastern Henrico
Henrico Master Gardener training program accepting applications through Oct. 28
A bountiful harvest
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Print Edition
Oct. 20, 2016Click here to read the print edition.
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'Survivorman' to visit Henrico Theatre
Weekend Top 10
Weekend Top 10
CAT Theatre to hold auditions for 'Wishing Well'
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Obituary – Mildred Terrell Tate
Obituary – Stephen Embry Esbach
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CalendarNational Theatre Live's thrilling broadcast of "Frankenstein" returns to cinemas for a limited time, due to unprecedented audience demand. The Modlin Center for the Arts at the University of Richmond will screen NT Live's "Frankenstein" at 7:30 p.m. in Camp Concert Hall, Booker Hall of Music. Starring Benedict Cumberbatch as the Creature and Jonny Lee Miller as Dr. Frankenstein. NT Live brings the best of British theatre direct from the stages of London to movie theatres around the world. Tickets are $7 to $14. For details, call 289-8980 or visit http://www.modlin.richmond.edu. Full text


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Yom Kippur War On The Golan Heights
A selection of articles related to yom kippur war on the golan heights.
Original articles from our library related to the Yom Kippur War On The Golan Heights. See Table of Contents for further available material (downloadable resources) on Yom Kippur War On The Golan Heights.
- The Aeonic Perspective of the Enochian Temples
- The initiatory system of the Enochian Temples divides the path of initiation into four major stages, distinguished primarily by the types and sources of the influences they are sensitive to. Briefly, these stages are: 1. Lunar-planetary, focused in Yesod and...
Magick >> Enochian
- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
Mystic Sciences >> Astrology
- Mother Of The Gods And The Father Of The Gael
- There is no surviving, or as yet translated, Creation story within Irish mythology. We learn from the Lebor Gabala Erenn, a text from the Christian Middle Ages, of the Tuatha De Danann, or "People of the Goddess Danu", who came to Ireland either...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- Select Cross-Cultural and Historical Personifications of Death
- This extensive introduction includes some of the more well known, along with some lesser known Death "incarnations", and I use that term loosely, as in many cultures, the Angel of Death can be quite an adept shapeshifter. We have tried to cull...
Mystic Sciences >> Necromantic Studies
- The Celtic Vedic Connection, Part I
- Of all the great ancient cultures perhaps no two share more parallels than those of the Celtic and Vedic peoples. A deep rooted affinity runs between them, what is present in one is mirrored in the other. Myths, Gods, Goddesses, even fairy tales bear a...
Religions >> Druidism
Yom Kippur War On The Golan Heights is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Yom Kippur War On The Golan Heights books and related discussion.
Suggested News Resources
- Yom Kippur War hero Avigdor Ben-Gal dies at 80
- "During the darkest days of the Yom Kippur War, when the fate of the nation hung in the balance, Yanush and his brave soldiers defended our northern border with their lives," Prime Minister Benjamin Netanyahu said, after news of Ben-Gal's death broke.
- Israel trip steeped in history and surprising serenity
- I soon join my tour bus and half-dozen fellow passengers as we drive through the Golan Heights, which straddles Syria, Lebanon, and Israel-friendly Jordan. ... Syria tried to retake the Golan during the 1973 Yom Kippur War and still demands it back.
- Israelis Are Just Dying to Teach Us Arabs About Love of Life
- Even in the 1973 October War that the Arabs initiated, all 2,656 Israeli casualties died in foreign lands. So who yearns for death, the one who dies at home or the one who dies in his neighbor's back yard?
- CAPTAIN COMICS: Novels provide glimpse of war's impact on humans
- "Children of Israel" is set in the 1973 Yom Kippur War, following a veteran tank commander and his reservist crew as part of the Israeli effort to defend the Golan Heights from Syrian/ Moroccan/Iraqi invasion.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Yom Kippur War On The Golan Heights Topics
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'Market talk' - Signifies information that has not been formally tested through traditional journalistic channels and therefore is to be treated as unsubstantiated. Any interpretation of the talk is taken at the readers own risk and is a representation of the rumours within the market place and never generated by ourselves.
Analysis details (18:38)
- There remains market talk of offers in EUR/USD between 1.3350 and 1.3360.
- Earlier in the session, Fitch affirmed Germany at AAA; outlook stable which is seen to support EUR.
- GBP also continues to weigh on the USD-index following the Bank of England's Quarterly Inflation Report release earlier today.
07 Aug 2013 - 18:32 - Forex Rumour - Source: RANsquawk
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dbForge Data Compare for MySQL is a fast, easy-to-use tool to compare and synchronize data of MySQL, MariaDB and Percona databases. The tool provides clear ... at a glance. It also allows scheduling regular MySQL data comparisons using command line. Key Features: * Support of all MySQL versions 3.23-5.x * Support of MariaDB, versions 5.5, .... Free download of dbForge Data Compare for MySQL 5.0
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Chicken Liver Pate With Onion
|Sliced onion
|8 Ounce
|Chicken livers/Liver sliced 1/3 inch thick
|1 Pound, cut in half
|Instant chicken broth and seasoning mix
|1 Tablespoon (1 Envelope)
|Poultry seasoning
|3⁄4 Teaspoon
|Leaf lettuce
|4 Cup (64 tbs)
|To Taste
|To Taste
Layer onions slices in a saucepan or non-stick skillet (with cover) and top with washed liver.
Cover and steam until onions are soft and liver is done (but still slightly pink and moist inside), about 15-20 minutes.
Sprinkle broth mix over onions.
Let cool, then transfer liver, onions and liquid in pan to blender container, and puree (or put through fine blade of meat chopper).
Stir in salt, pepper, and poultry seasoning.
Chill and serve cold in lettuce leaf cups.
Rate It
Nutrition Rank
Nutrition Facts
Serving size: Complete recipe
Calories 653 Calories from Fat 204
% Daily Value*
Total Fat 23 g34.9%
Saturated Fat 7.3 g36.7%
Trans Fat 0.3 g
Cholesterol 1565 mg521.7%
Sodium 808.8 mg33.7%
Total Carbohydrates 28 g9.4%
Dietary Fiber 6.3 g25.2%
Sugars 11 g
Protein 82 g163.5%
Vitamin A 1232% Vitamin C 209.6%
Calcium 18.1% Iron 243.9%
*Based on a 2000 Calorie diet


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Without Doan, Coyotes in survival mode
Still minus captain, Coyotes clinging to bottom of playoff ladder after again scrapping way to point but coming up short.
GLENDALE, Ariz. -- There are hot streaks over the course of an NHL season, and there are times when a team just looks to survive.
With captain Shane Doan and key defenseman Zbynek Michalek still out of the lineup for an indefinite period of time, it sure feels like the latter for the Coyotes.
Phoenix played well enough for much of Friday's post-holiday game with San Jose at Jobing.com Arena. But once the game went to a crapshoot, -- er, shootout -- San Jose's superior firepower took over and the Sharks took two points with a 4-3 victory while the Coyotes continued to cling to the bottom of the Western Conference playoff standings with another one-point game.
"You'll take a lot of good things that we did out of this game," coach Dave Tippett said. "I told the players, 'If we can play at this level the majority of the time, we'll get our fair share of points.'"
The question is: Will the Coyotes be able to stack enough points while Doan and Michalek are out to stick around in the Western Conference playoff race? Minnesota and Colorado are helping their cause by slumping while Dallas has crept back into the race with a 6-3-1 stretch. But the elite teams of the West are starting to open a gap between themselves and the middle of the conference, which could mean fewer playoff spots up for grabs.
The Coyotes are 14 points behind conference leader Chicago and 13 points behind Pacific Division leading Anaheim, their road opponent in a quick turnaround Saturday at 5 p.m. With the one point earned, Phoenix sits alone in eighth place, two points ahead of the Stars, one point ahead of the Wild and three points behind the Avalanche.
It feels like the West is splitting into three distinct classes: the elite, the hopefuls and the dregs. The Coyotes at least want to make sure they stay in the middle class.
"Any time you're playing in close games, you'd like two (points), but with the way things are now, when they go to a shootout, itâs one of those things where sometimes you're hot and winning them, other times you struggle," said forward David Moss, who had a pair of goals just one day before his 32nd birthday. "We battled hard. We found a way to claw back in the game when they got the lead."
San Jose took a 3-2 lead midway through the third period when Brent Burns slipped free of Antoine Vermette's check in the slot and buried a feed from Joe Pavelski behind the net.
But Phoenix scored on its second power play of the game when Mike Ribeiro drew two players to him along the boards and then slipped a pass across the ice to Radim Vrbata, who waited for Martin Hanzal to set up a partial screen and then ripped a wrist shot past Sharks goalie Antti Niemi to ensure the Coyotes got at least a point.
"I really think we moved it around well on the power play, so that's a good thing, a positive thing to build on," Vrbata said.
Until Doan returns, the Coyotes may have to settle for those smaller victories.
"You don't just miss him on the ice. You miss him in the dressing room, like when we had that long road trip," Vrbata said. "Everybody goes through it, but that's a big hole and a key part of our team that we hope will be back soon."
Follow Craig Morgan on Twitter


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The Great Lakes ADA Center is pleased to offer a variety of conferences and training
opportunities regarding the Americans with Disabilities Act of 1990. Programs highlighted
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