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Nicobar Long Tailed Macaque Behaviour
A selection of articles related to nicobar long tailed macaque behaviour.
Original articles from our library related to the Nicobar Long Tailed Macaque Behaviour. See Table of Contents for further available material (downloadable resources) on Nicobar Long Tailed Macaque Behaviour.
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
- Can You Bhoga All Night Long? An Introduction to Tantra, East and West
- When you hear the word Tantra, what images come to mind? Turbans and Sitar music? Mind-blowing sex? Most people in the Western world have heard the word Tantra, but few know anything in detail about what it means. The situation in India isn't much different....
Body Mysteries >> Yoga
- What is hypnotic trance? Does it provide unusual physical or mental capacities?
- 2.1 'Trance;' descriptive or misleading? Most of the classical notions of hypnosis have long held that hypnosis was special in some way from other types of interpersonal communication and that an induction (preparatory process considered by some to be...
Parapsychology >> Hypnosis
- A Treatise on Astral Projection, Part 2: Training
- To trigger the projection of the Astral body, while fully conscious, there are four major requirements: Relaxing your body 100% while staying awake. Concentrating 100% on what you are doing. Having enough energy available. Pressuring the astral body to...
Parapsychology >> Astral Projection
- You May Be Using Sunlight in Your Magic (And Not Even Know It!)
- A Circle is cast between the worlds. This space is filled by gentle candle light, and filled with the scent of fragrant herbs. Energy is raised, focused with purpose and then released with a sudden "whoosh." While there are many types of energy used...
Paganism & Wicca >> Spells
- A Basic View of Paganism or Bambi Pagansim
- "You people are all so nice! I like the idea of Paganism, but I don't think I could be that nice all the time." The writer was genuinely perplexed and driven to ask me if it is really possible that Pagans, Witches and Wiccans really lived such...
Religions >> Paganism & Wicca
Nicobar Long Tailed Macaque Behaviour is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Nicobar Long Tailed Macaque Behaviour books and related discussion.
Suggested News Resources
- Macaques back from tsunami
- Conservation biologists have documented a three-fold increase in the population of long-tailed macaque monkeys on the tsunami-hit Nicobar islands, marking a rare recovery of a species pushed towards the brink of a localised wipe-out.
- You can thank wasps for your bread, beer and wine
- If wasps didn't exist, picnics would be a lot more fun. But the next time you find yourself trying to dodge a flying, jam-seeking harpoon, think about this: without wasps, many of your ingredients might not exist at all.
- Will we ever grow organs?
- "We're still a long way from full replacement, but I do believe that these technologies are achievable.
- Why supermarket tomatoes look great but taste bland
- If you've ever bitten into a wild tomato, you'll have enjoyed a sweet, intense explosion of flavour. The tomatoes that line most supermarket shelves are a world apart. They look great – a wall of even, ripe red – but they taste like cardboard.
- Harmless soil bacteria are trading weapons with those that kill us
- There are bacteria in the soil that can resist our antibiotics. That's predictable – these drugs are our versions of natural compounds that bacteria have been assaulted with for millions of years. Of course, they would have evolved resistance.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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5Rating Pet Supplies 1.0.19
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LOS ANGELES -- USC assistant coach Monte Kiffin said the Trojans used their extreme underdog status leading into Saturday's game against Oregon as a way to motivate their players.
In fact, Kiffin told his Trojans just how much the Ducks were favored to win by in Las Vegas and emphasized to them all week that few people believed they could pull off the upset. USC defeated then-No. 4 Oregon, 38-35, on the road at Autzen Stadium.
"On Monday, I was checking the point spread," Kiffin said Monday on the Mason & Ireland Show on 710 ESPN radio. "I loved it. I put it on the first time we met, Tuesday morning, with the defense and I said, '19-point underdog? Are you kidding me?' We were eight-and-a-half point [underdogs] at Notre Dame and we thought that was a lot.
"Bring it on, baby. I love it."
Most Las Vegas sports betting lines had Oregon favored by about 16 points at the start of the week. That was lowered to around 14.5 points by kickoff on Saturday, meaning most people bet in favor of USC during the week.
"I'll tell you what now, when you look at that, I really do think it was a heck of an upset," Kiffin said.
Kiffin and his son Lane, the Trojans' head coach, have often said they pay little to no attention to point spreads. But both men made frequent reference to USC's upset over the Irish in October, and Lane talked often last week about the benefit of being an underdog before the Oregon game.
"A lot of times in these games the pressure goes the other way with a team that has a chance to go to the national championship still," Lane Kiffin said before the game. "We'll just go up there, have some fun and see what happens."
Pedro Moura covers USC for ESPNLosAngeles.com.


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NeoGeo Games
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- Genre: Action Fighting
- Release: Jan 28, 1999
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November 25, 1963: A funeral was held for Dallas Police Officer J.D. Tippit, who was gunned down by Lee Harvey Oswald. Tippit was buried at Laurel Land Memorial Park in Dallas.
Published at 2:58 PM GMT on Sep 4, 2013 | Updated at 5:42 PM GMT on Sep 18, 2013


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A fable of revenge and redemption, the people of a Latin American village are reeling from the impact of a devastating civil war when a mysterious plague begins to ravage their children. An embittered doctor discovers that he could be their savior, but he must wrestle with his own soul to discover whether he wants to offer compassion or retribution.
Narrated by the ghost of a missing 15-year-old girl, and woven together by a chorus of parents of lost and missing children, Zadravec's lyrical, edgy poetry explores the cost one family is willing to pay for a second chance. In an effort to get their lives on track, recovering addicts Mark and Julia have taken over an apple orchard in rural Oregon when their estranged son reappears in their lives. With little experience and a family in crisis, the couple quickly realizes they are in over their heads, yet they believe if they produce a viable crop, a new beginning is possible. Set against the contemporary plagues of meth addiction, missing children, and a failing ecology, Colony Collapse is equal parts Greek tragedy and American drama, illuminating a search for humanity in a world with little shelter from harm.
What starts out as a simple toothache evolves into a dizzying chain of events as a group of disparate people, played by a cast of five who assume many roles indiscriminate of age, gender, and race, struggle to make connections in an increasingly isolated world. At the center of the story is a Thai/Chinese/Vietnamese restaurant, The Golden Dragon, where a young Chinese man suffering from an oversensitive incisor sparks a whacked and weird series of interconnected stories. A delicious mixture of epic theatre, bizarre comedy, poetry, and fable combine to create this fabulous pho.
Two brothers, both musicians. The classical pianist is Christian. The jazz bassist is Muslim. When Bilal is accused of being a terrorist and jailed awaiting trial, Eric tries to stay connected by pushing aside his own classical aspirations in order to learn big brother's jazz style. Separated by prison bars and religious convictions, the brothers scat and be-bop through their shared language of music.


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Best Neighborhood Restaurant in Broward
Il Mulino has great food, good prices, and terrific service, but it's not well-known outside of the Victoria Park/Middle River Terrace/Coral Ridge area, so you can get a table in less than 30 minutes during season. Our bottom line for an Italian restaurant is garlic rolls that would kill a vampire, and Il Mulino is definitely unsafe for any of Anne Rice's creations. With pasta dishes all in the $9 to $11 range, pizzas under $10, and only three specialties that will cost you more than $15, you can still afford a movie at the neighboring Gateway Cinema after the meal. Some of our favorite dishes are a Caprese salad with more fresh mozzarella cheese than most pizzas, an appetizer called fagottino we like just because the name makes us laugh, and six versions of anelli, a concoction of anything from artichoke hearts, asparagus, and sun-dried cranberries to chunks of filet mignon with mushrooms, roasted peppers, and mozzarella inside a crusty baked dough. Traditionalists can get eggplant parmigiana, veal marsala, or linguine with clams, but don't expect the fish-flavored broth they serve in lesser establishments. Here, your linguine will be prepared with Little Neck clams, basil, wine, and, of course, the garlic.
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Katy Perry and Eminem 'Roar,' go 'Berzerk' atop this week's Spotify charts
The following list represents the top streamed tracks on Spotify from Monday, Aug. 26, to Sunday, Sept. 1:
1. Katy Perry, "Roar" (Capitol)
2. Avicii, "Wake Me Up" (Universal)
3. Lorde, "Royals" (Republic Records)
4. Jay Z, "Holy Grail" (Roc Nation)
5. Robin Thicke, "Blurred Lines" (Star Trak LLC/Interscope)
6. Lady Gaga, "Applause" (Interscope)
7. Miley Cyrus, "We Can't Stop" (RCA Records)
8. Drake, "Hold On, We're Going Home" (Cash Money Records)
9. Imagine Dragons, "Radioactive" (KIDinaKORNER/Interscope Records)
10. Capital Cities, "Safe and Sound" (Capitol)
The following list represents the most viral tracks on Spotify, based on the number of people who shared it divided by the number who listened to it, from Monday, Aug. 26, to Sunday, Sept. 1, via Facebook, Tumblr, Twitter and Spotify.
1. Eminem, "Berzerk" (Aftermath Records)
2. Miley Cyrus, "Wrecking Ball" (RCA Records)
3. Avicii, "You Make Me" (Avicii Music AB)
4. Enrique Iglesias, "Loco" (Universal Republic)
5. Lorde, "Royals" (Lava Music/Republic Records)
6. Klingande, "Jubel" (Klingande)
7. Two Door Cinema Club, "Changing of the Seasons" (Glassnote)
8. Mary Lambert, "She Keeps Me Warm" (Mary Lambert)
9. Ellie Goulding, "Tessellate" (Polydor Ltd)
10. Drake, "Hold On, We're Going Home" (Cash Money Records)
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Canal Street Manchester History
A selection of articles related to canal street manchester history.
Original articles from our library related to the Canal Street Manchester History. See Table of Contents for further available material (downloadable resources) on Canal Street Manchester History.
- Indian History Rewritten
- The Indian civilisation, considered to be the product of clash and subsequent inter mixture of the white-skinned civilised invaders and the dark savages native to India, has been rightly questioned in recent years, and the mischievously fabricated history of...
History & Anthropology >> Indic / Vedic
- The Truth Behind the History of the Necronomicon
- I don't think there are many people out there who haven't heard of the Necronomicon and the dreadful things connected with it. We've all heard the theories about how it is a Satanist tool; actual copies of the book are bound in human skin and how you risk...
Deities & Heros >> Chthulu
- History of the Egyptian Religion, part I: Early Dynastic Period
- I - Predynastic - Early Dynastic Period. The temples were in essence the *Home of the God* and thus a place where only Pharaoh as the Son of God and those he appointed as his deputies, could meet with the god. This goes all the way back to Archaic and...
Religions >> Egyptian
- History of Egyptian Medicine and Philosophy
- When medical knowledge past is considered, lack of aseptic technique, pain-killing drugs and antibiotics are an accepted part of our modern legend of these ancient healing practices. You will find that none of this is true when it comes to Ancient Egypt....
Religions >> Egyptian
- History of the Egyptian Religion, part II: The Old Kingdom
- II - The Old Kingdom ca 2686-2181 BC During the Old Kingdom the Egyptian society moved from tribal communities to a fully developed theocratic system, where the power of the king was absolute. The great pyramids of Dynasty 4 was made possible by technological...
Religions >> Egyptian
Canal Street Manchester History is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Canal Street Manchester History books and related discussion.
Suggested Pdf Resources
- MANCHESTER HISTORY - City of Richmond
- Nov 26, 2012 The mill canal terminated just east of Hull Street at a large pond that overflowed into the natural channel of Walker's Creek. LEFT Manchester ...
- www.richmondgov.com
- Manchester On Foot
- is much more to Manchester's history than the story of one company. The thriving city has ... When you reach Canal Street cross the northbound lane at the cross ...
- www.nhia.edu
- manchester, new hampshire downtown area map - Greater
- www.manchester-chamber.org
- RVA Downtown Development Snapshot - Venture Richmond
- Six-acre site along Byrd St and the Haxall and Kanawha Canals, between 10th and ... Completes final stretch of Richmond's 1.3 mile Canal Walk corridor.
- www.venturerichmond.com
- Rochdale Canal - Manchester Geographical Society
- An Architectural History, Manchester University Press, Manchester. Warrender, K. ...
- www.mangeogsoc.org.uk
Suggested News Resources
- Good Morning, RVA: A weekend approaches!
- The RVA Street Art Fest–you know, the folks responsible for the wonderful art at the GRTC Bus Barn and down by the canal–returns after a quick hiatus. They're headed to Manchester, near the Southern States grain silos, and Brent Baldwin at Style Weekly ...
- MIPIM 2016: All eyes on Manchester vision
- Manchester life is set to build more than 6,000 new homes in parts of east Manchester, with schemes on New Union Street, Murrays' Mills, Jersey Street site, and Hood Street site. He said: "We are trying to raise the aspirations of ...
- Paint the town green as Queen City welcomes back St. Patrick's Parade
- He has been a member of the Manchester Division 1 of the Ancient Order of Hibernians, serving as treasurer and president. He has served as treasurer and coordinator of the St.
- Here's what Manchester's Gay Village on Canal Street looked like in 1997
- When Manto opened in 1990, it had already firmly established itself as a part of the city committed to sexual tolerance and equality, but certainly the huge bar on Canal Street was a real catalyst for substantial development in the area.
- The 66000-pound fuel tank of a space shuttle, the last of its kind, is on its
- When the space shuttle Endeavour crawled through the streets of Los Angeles to the California Science Center in 2012, it was missing something: the giant external fuel tank on which it rode piggyback into space. There was ...
Suggested Web Resources
- Canal Street (Manchester) - Wikipedia, the free encyclopedia
- History[edit]. Canal Street developed when the Rochdale Canal was constructed in 1804, a trade artery running through the city.
- en.wikipedia.org
- Village History - Canal-st.co.uk
- Canal Street and its History - Article updated Dec 2010 ... Manchester's current ' Gay Village' developed alongside the Rochdale Canal, which still runs through ...
- www.canal-st.co.uk
- The Gay UK | HISTORY: Manchester Canal Street
- May 30, 2013 Manchester Gay Village has a long history that makes it truly vintage. Starting as an underground scene in the sixties, through the decades it ...
- www.thegayuk.com
- Articles - LGBT - Canal Street History - Visit Manchester - The official
- Canal Street history. Uncover the past of Manchester's 'Gay Village'.
- www.visitmanchester.com
- A Stroll Down Canal Street in Manchester - YouTube
- Jul 7, 2010 A travelogue about Manchester's famous Canal Street, the heart of ... 2013 - a lively modern city with interesting, mainly Victorian, history.
- www.youtube.com
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Canal Street Manchester History Topics
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I decided to have fun today. I made Tootsie roll flowers and bubble gum flowers. Made them in a Bouquet and painted a little gold lustre dust on them. I'll bring it to my moms-meeting this afternoon. I'm sure the other moms will like to munch on them at the break!
super idea....looks wonderful!!
Wow you did a awesome job. I love the idea.
What a neat cake! Great job!
CakeCentral.com is the world's largest cake community for cake decorating professionals and enthusiasts.
(if this is a private computer)
Yes please, register now!


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Shanahan, Cynthia; Shanahan, Timothy – Journal of Adolescent & Adult Literacy, 2014
During the past several years, middle schools and high schools have been shifting their attention to disciplinary literacy. The Common Core State Standards are explicit in requiring teachers to teach the literacy of science, literature, and history, and even states that are not part of Common Core (such as Texas) are making this shift as well.…
Descriptors: Middle Schools, High Schools, Content Area Reading, Content Area Writing
Shanahan, Timothy – Educational Leadership, 2013
Does the Common Core State Standards' focus on informational text mean that teachers must teach fiberglass installation manuals and the minutes of National Reserve Board meetings? No, responds literacy expert Timothy Shanahan. "I've pored over the lists of exemplary texts suggested by the standards, and I've not been able to…
Descriptors: Academic Standards, Reading Instruction, Content Area Reading, Language Arts
Shanahan, Timothy – Literacy Research and Instruction, 2016
In their article "Beyond the Common Core…," Cassidy, Ortlieb, and Grote-Garcia (2016), express concern that the new Common Core State Standards (CCSS; National Governors Association [NGA] Center for Best Practices & Council of Chief State School Officers [CCSSO], 2010) may have the "unintended consequence" of diverting…
Descriptors: Common Core State Standards, Reading Difficulties, Teaching Methods, Educational Objectives
Trehearne, Miriam P. – Corwin, 2011
"Learning to Write and Loving It!" equips teachers of young children with practical strategies, assessment tools, and motivating writing activities that are based on current research and proven practice and are easily applicable to all kinds of learning environments. Included are many authentic writing samples and photos to illustrate effective,…
Descriptors: Play, Young Children, Educational Technology, Literacy
Troia, Gary A., Ed. – Guilford Publications, 2009
This book focuses on how to provide effective instruction to K-12 students who find writing challenging, including English language learners and those with learning disabilities or language impairments. Prominent experts illuminate the nature of writing difficulties and offer practical suggestions for building students' skills at the word,…
Descriptors: Writing Instruction, Elementary Secondary Education, Writing Difficulties, Writing Workshops
Shanahan, Timothy – Phi Delta Kappan, 2005
Timothy Shanahan was surprised to learn that Elaine Garan and Steven Krashen had written yet two more critiques of the National Reading Panel (NRP) report. Each already has more NRP-related publications than any member of the panel, and both have been issuing their complaints over a longer period than the panel worked on the eight studies that…
Descriptors: Reading Instruction, Reading Research, Criticism
A Special Section on Reading Research--Reading between the Lines: Observations on the Report of the National Reading Panel and Its Critics
Cooper, Harris – Phi Delta Kappan, 2005
This article evaluates the "Report of the National Reading Panel: Teaching Children to Read: An Evidence-Based Assessment of the Scientific Research Literature on Reading and Its Implications for Reading Instruction: Reports of the Subgroups" (National Institute of Child Health and Human Development, 2000). The author also examines the following…
Descriptors: Teaching Experience, Teaching Methods, Reading Research, Boards of Education
A Special Section on Reading Research--Murder Your Darlings: A Scientific Response to the Voice of Evidence in Reading Research
Garan, Elaine M. – Phi Delta Kappan, 2005
Writers know how easy it is to be seduced by their own cleverness. Words and ideas have a way of turning heads as they take on lives of their own. However, the time comes when good writers must harden their hearts, sharpen the axe, and murder their darlings. The same must be said of good scientists. Even more so than with writing, ethical…
Descriptors: Teaching Methods, Scientists, Reading Instruction, Reading Research
Cummins, Carrice Ed. – International Reading Association (NJ3), 2006
Administrators in the U.S. education system need to be more than good managers, they need to understand high-quality reading instruction, so they can serve their teachers and help their school meet Reading First requirements. Although written with the administrator in mind, this collection also can be used by teachers, teacher educators, staff…
Descriptors: Reading Instruction, Administrator Role, Leadership, Federal Legislation
Snow, Catherine E.; Porche, Michelle V.; Tabors, Patton O.; Harris, Stephanie R. – Brookes Publishing Company, 2007
Four literacy experts lay out the evidence in this compelling book, based on the well-known Home-School Study of Language and Literacy Development that inspired the landmark resource "Beginning Literacy with Language." Following a group of children living in low-income families from preschool through high school, the authors charted the students'…
Descriptors: Literacy, Literacy Education, Adolescents, Reading Comprehension
Rasinski, Timothy Ed.; Blachowicz, Camille Ed.; Lems, Kristin Ed. – Guilford Publications, 2006
Because fluency instruction was identified, only recently, as a cornerstone literacy subject--it is still unfamiliar terrain for many teachers. This volume fills a crucial gap by offering a thorough, authoritative examination of what reading fluency is--and how it should be taught. Contributing authors, who include the field's leading authorities,…
Descriptors: Program Effectiveness, English (Second Language), Theater Arts, Silent Reading
Shanahan, Timothy – Reading Teacher, 2015
This column explains three ways that teachers can improve reading test performance. Basically, the idea is that instead of teaching students to respond to particular question types as is typical of test preparation despite the ineffectiveness of this practice, it is better to teach students to read the test passages more effectively. Three…
Descriptors: Scores, Reading Tests, Teaching Methods, Test Preparation
Shanahan, Timothy – Reading Teacher, 2015
In 2010, more than 40 states adopted the Common Core State Standards. Initially, the standards were quickly and easily embraced, but over the past year the standards have become enmeshed in various controversies, raising many questions about how the standards were written and what they include. This article attempts to provide authoritative…
Descriptors: State Standards, Academic Standards, Government Role, Policy Formation
Shanahan, Timothy – Elementary School Journal, 2015
The Common Core State Standards for the English Language Arts, together with the new tests being developed to assess them, are placing a greater emphasis on writing in elementary schools than in the recent past. This article explores similarities and differences of the standards with past state standards, explaining the reason both for why things…
Descriptors: State Standards, Language Arts, Elementary School Curriculum, Educational Change
Stahl, Katherine A. Dougherty, Ed.; McKenna, Michael C., Ed. – Guilford Publications, 2006
This book presents state-of-the-science research on the components of successful literacy learning and how to target them in contemporary classrooms. The volume builds on and extends the work of Steven Stahl, whose pioneering contributions encompassed the key areas of phonemic awareness, phonics, vocabulary, fluency, comprehension, and assessment.…
Descriptors: Reading Instruction, Educational Research, Educational Trends, Teaching Methods


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2 posts tagged with browser by zardoz.
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Help me with my internet annoyance.
I sometimes have trouble with downloading via torrent: surfing becomes a slow crawl/not an option. [more inside]
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I'm having some really strange cookie issues with Firefox (2.01). For starters, I can't access www.google.com... [more inside]
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Poinsettia Wedding Bouquets
Many brides and grooms choose a day during the cold seasons for their wedding. This is especially the case of those who love Christmas holidays and wish to spend their big day around this big date. Chances are you will be able to book your wedding precisely on a Christmas day are not very high. But if you do try to make this choice early in the process of planning your wedding you have bigger hopes to obtain it. The truth is that popular holidays are very expensive when interpreted as wedding dates.
The venues are always full and expensive during this time of the year. But you should not feel discouraged. If this is your wedding dress, then you should do anything in your power to obtain perfect results. We love winter brides because they are very glamorous and sensual. The red color is the color of winter, at least in what it may concern the romantic type or bride. She always prefers red over white, although many winter brides decide to go for a red & white wedding theme. You can use red as an accent and white for the background.
The contrast between these two hues is gorgeous anyway. There are a lot of sparkles and snowflakes going on, as well as a lot of warm nuances and cozy moments during a winter wedding. We especially love poinsettias. These unique flowers are so specific for winter events that we can't even think of a different species for a winter bride's bouquet. Poinsettias are beautiful red flowers with a rich appeal, texture and color. Poinsettia flowers are ideal for Christmas weddings as they bloom only during this period. This is the most impressive quality of poinsettias. What more could a bride wish for her winter holiday themed wedding? You can find these blooms in abundance during the winter holiday season. And this means that you will be able to save a lot of money by purchasing dozens of blooms.
You can use poinsettias for your bouquet and for the groom's boutonniere. But it wouldn't be a bad idea to insert a few in the centerpieces or décor. We have a think for the arrangements that contain roses and poinsettias. These two types of flowers make a fabulous mix, especially when used in red and white or only in one of these hues. If you want to obtain a fascinating bouquet for your wedding, combine crimson poinsettias with milky white rose blooms. For the tables, you can change the style and create mismatched centerpieces. Get creative and alternate roses and poinsettias the way you want. You have plenty of time to experiment. For a less holiday-like appearance, use white poinsettias.


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Applegarth, Conaway
KATHY APPLEGARTH of Dillonvale announces the engagement of her daughter, Tammy Jo Applegarth, to Paul Conaway Jr., the son of Paul and Judy Conaway of Rayland.
The bride-to-be is a 1992 graduate of Buckeye Local High School and a 1997 graduate of Ohio University. She is employed by Columbus City Schools as a pre-kindergarten teacher.
Her fiance is a 1994 graduate of Bellaire St. John High School and is employed by Worthington Industries.
A wedding is planned for June 25 at Giffin Center Church in St. Clairsville.


text:
realmagick.com The shrine of knowledge.
Chinese Qigong Massage
A selection of articles related to chinese qigong massage.
Original articles from our library related to the Chinese Qigong Massage. See Table of Contents for further available material (downloadable resources) on Chinese Qigong Massage.
- Chinese Zodiac Signs: An Overview
- Chinese zodiac presented the character of persons born under each sign in twelve consecutive years. Each year are represented by the twelve animals, as follows
Mystic Sciences >> Astrology
- Reiki, Questions & Answers
- Q. Where does Reiki energy come from? A. Reiki energy is a subtle energy. It is different than electricity or chemical energy or other kinds of physical energy. Reiki energy comes from the Higher Power, which exists on a higher dimension than the physical...
Body Mysteries >> Reiki
- Healing with Reiki
- "Happiness is a sort of action" Aristotle A Reiki healing is a great example of letting everything be as it is, of doing by not doing but just simply being there, of going with the flow. One of the truths of Reiki namely is, that the healee - not...
Body Mysteries >> Reiki
- Experiences of a Pagan Practicing Pranic Healing
- My exposure to the Old Religion and to the Earth-based Religion also exposed me to tried and true healing techniques involving herbs, oils and some other shamanic rites. Most of these techniques did not ritualize a systematic division of bodies and/or energy...
Body Mysteries >> Pranic Healing
- Herbs of Folklore and Modern Medicine: White Willow, Aloe Vera, and Garlic
- Many of the medicinal herbs we use today have been studied by modern science for application in today's medical field. These studies have shown that our ancestral folk uses of these herbs were very much correct in their applications. Here we will explore...
Earth Mysteries >> Herbalism
- What is Reiki?
- A Brief Overview The knowledge that an unseen energy flows through all living things and is connected directly to the quality of health has been part of the wisdom of many cultures since ancient times. The existence of this "life force energy" has...
Body Mysteries >> Reiki
- Preparations for Sex Magick
- "Spectacular achievement is always preceded by spectacular preparation." Robert H. Schuller The first thing is being a good body with your body ! Human bodies are beautifully shaped and wondrously working temples of the soul; in sex magick the body...
Body Mysteries >> Sexuality
Chinese Qigong Massage is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Chinese Qigong Massage books and related discussion.
Suggested News Resources
- New Space Brings New Vibes
- These forms include cranial sacral therapy, Tui Na massage and medical Qi Gong.
- Learn how to improve your life with Qigong
- Among the new classes to be held at the West Linn Adult Community Center is Qigong, an ancient Chinese health care system that integrates physical postures, breathing techniques and focused attention. The word Qigong (Chi Kung) is ...
- An A-to-Z Guide to Bullshit Alternative Medicine on YouTube
- Have you ever gotten a massage that was so rough it actually hurt? Cool. Now imagine that you say, "Hey, could ...
- Breast cancer group to host acupuncture talk
- Sometimes they're medical and sometimes they've been for massage therapy or things that might pertain to different aspects of their recovery." Ferst practices in ...
- Can you really sort out your life - in five hours?
- She offers these five-hour slots – as well as more conventional weekly one-hour sessions, and four-day retreats in Somerset where counselling is combined with massage, aromatherapy and soul food – for those who need a fast fix.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Chinese Qigong Massage Topics
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Encore for popular Callas stage show
Published 27/01/2013 | 05:00
Casta Diva – The Life, Loves and Music of Maria Callas is a new stage show about the life of Maria Callas, told through the music that made her famous.
The show covers the Onassis years, his betrayal of her with Jackie Kennedy and Maria's tragic end. Mairead Buicke stars as Maria Callas, singing classics from Madame Butterfly, La Traviata and Tosca.
It's the most successful series of National Concert Hall shows in years, with four sell-out performances so far – and tickets for the show on Sunday, February 10, are bound to be much sought after. Tickets from the NCH.
Sunday Independent


text:
Mhamid Vacation Packages
Rabat, the national capital, is situated 300 miles (483 kilometers) north of Mhamid.
Why not spend some time exploring the area? Start with a trip to the the Mhamid Main Square.
Of course, limiting yourself to only one place usually only offers a small window into the wider rhythms and life-ways of a region. So be sure to discover Ouarzazate - South Eastern Morocco's range of attractions. Tamgrout and Zagora are two other places worth seeing while you're in Ouarzazate - South Eastern Morocco.
Ouarzazate - South Eastern Morocco offers visitors some significant mosques and other holy sites, ideal places to get an insight into the region's soul. Learn something new by spending a few hours at Ouarzazate - South Eastern Morocco's fascinating history museums.
If you're traveling in Mhamid on the 30th of July, partake in the events surrounding the nation-wide Throne Day celebrations.
A wise person once said: it's better to see something once than to be told about it a million times. With its stunning beauty Mhamid will exceed your expectations.


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Constitution Of Pakistan Amendments
A selection of articles related to constitution of pakistan amendments.
Original articles from our library related to the Constitution Of Pakistan Amendments. See Table of Contents for further available material (downloadable resources) on Constitution Of Pakistan Amendments.
- The Pagan Roots of Democracy
- I stepped into the voting booth with civic pride and religious inspiration. The pastors urged the congregation to renew America and vote for a good Christian man, Ronald Reagan. I voted a straight Republican ticket. Those godless Democrats were no better than...
Saga of Times Past >> History & Anthropology
- The Thinking Rede
- It would be much easier if the Rede acted like a giant Magic Eight Ball. Ask it a question, shake the ball, and wait for "yes," "no," or "absolutely!" to float to the top of the murkey window. Unfortunately, the deceivingly...
Paganism & Wicca >> The Wiccan Rede
- Astrological Emphasis: Capricorn, 2001
- General | Love | Work | Health Capricorn: 22 December, 2000 - 20 January, 2001. This article applies to Capricorns during 2001. General Those born under this sign, ruled by Saturn, have a strong practical sense. They have a strong constitution, a prominent...
Astrology >> Capricorn
- Echinacea, the Sacred Plant
- A full grown Echinacea-plant is an impressive and decorative appearance. You may consider giving her a place in your garden. This beautiful plant will probably steal your heart with her large, colorful and long lasting flowers. No doubt you have heard of...
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- Burn Box – Demon Rost: The supression of free speech and religion
- Those were the words on a sign that was hung from the coat rack in the vestibule of the 45-member Harvest Assembly of God Church on Brownsdale Road in Penn Township, Pennsylvania. 40 members of the church, led by Rev. George Bender, held a book and video...
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- Everything you always wanted to know about the beliefs of the Founding Fathers that your Congressman will never tell you!
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Saga of Times Past >> History & Anthropology
- Holy Oak
- The majesty of the Oak has been recognized by many cultures. The Celts, the Germanic and Nordic tribes, and the ancient Greeks all attributed this tree to their main god. To them the Oak represented power, protection and durability. The fiery Oak has strong...
Herbalism >> Herbs dictionary O
Constitution Of Pakistan Amendments is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Constitution Of Pakistan Amendments books and related discussion.
Suggested Pdf Resources
- the constitution of the islamic republic of pakistan - National
- Apr 20, 2010 The National Assembly of Pakistan passed the Constitution on 10th ... the Constitution, incorporates all amendments made in it till date.
- www.na.gov.pk
- Pakistan's Constitution of 1973, Reinstated in 2002, with - Constitute
- Comparative Constitutions Project, and distributed on constituteproject.org. constituteproject.
- www.constituteproject.org
- Amendments to the Constitution of Pakistan
- Aug 16, 2004 parliamentarians with the details of constitutional amendments so far brought to ... Amendment Constitutional and Political Crisis in Pakistan'.
- www.millat.com
- Proposed Amendments to the Constitution of Pakistan - PILDAT
- up recently to consider various amendments to the Constitution of Pakistan. Mr. Shahid Hamid deserves credit for not only his initiative of penning down an ...
- www.pildat.org
- 21st Constitutional Amendment
- The 21st Amendment- Bill 2015 and the Pakistan Army. (Amendment) Bill 2015: Seek to amend the Constitution and the Pakistan Army Act 1952 to give a.
- www.riphah.edu.pk
Suggested News Resources
- Bangladesh Court to Hear Petition to Remove Islam as State Religion
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- LS passes Enemy Property Act amendment Bill: Opp protests, BJP MP says include
- AS THE Lok Sabha passed the Bill to amend the Enemy Property Act 1968 on Wednesday, a BJP MP demanded that its ambit be expanded to include those convicted in sedition cases. ...
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- The United States essentially delivered an ultimatum to the Cubans: Incorporate the Platt Amendment into your constitution or we will not withdraw our troops on the island.
- Privatisation process of national highways to start soon, PAC informed
- Khurshid Shah said any decision before privatisation of highways should be taken in consultation with provinces, adding that new constitutional amendments will add power to the provinces.
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Constitution Of Pakistan Amendments Topics
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Most Cited BBA Proteins and Proteomics Articles
The most cited articles published since 2011, extracted from Scopus.
Cysteine cathepsins: From structure, function and regulation to new frontiersVito Turk | Veronika Stoka | Olga Vasiljeva | Miha Renko | Tao Sun | Boris Turk | Dušan Turk
Volume 1824, Issue 1, January 2012, Pages 68-88
It is more than 50 years since the lysosome was discovered. Since then its hydrolytic machinery, including proteases and other hydrolases, has been fairly well identified and characterized. Among these are the cysteine cathepsins, members of the family of papain-like cysteine proteases. They have unique reactive-site properties and an uneven tissue-specific expression pattern. In living organisms their activity is a delicate balance of expression, targeting, zymogen activation, inhibition by protein inhibitors and degradation. The specificity of their substrate binding sites, small-molecule inhibitor repertoire and crystal structures are providing new tools for research and development. Their unique reactive-site properties have made it possible to confine the targets simply by the use of appropriate reactive groups. The epoxysuccinyls still dominate the field, but now nitriles seem to be the most appropriate "warhead". The view of cysteine cathepsins as lysosomal proteases is changing as there is now clear evidence of their localization in other cellular compartments. Besides being involved in protein turnover, they build an important part of the endosomal antigen presentation. Together with the growing number of non-endosomal roles of cysteine cathepsins is growing also the knowledge of their involvement in diseases such as cancer and rheumatoid arthritis, among others. Finally, cysteine cathepsins are important regulators and signaling molecules of an unimaginable number of biological processes. The current challenge is to identify their endogenous substrates, in order to gain an insight into the mechanisms of substrate degradation and processing. In this review, some of the remarkable advances that have taken place in the past decade are presented. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
Protein-surfactant interactions: A tale of many statesDaniel Otzen
Volume 1814, Issue 5, May 2011, Pages 562-591
The scientific study of protein surfactant interactions goes back more than a century, and has been put to practical uses in everything from the estimation of protein molecular weights to efficient washing powder enzymes and products for personal hygiene. After a burst of activity in the late 1960s and early 1970s that established the general principles of how charged surfactants bind to and denature proteins, the field has kept a relatively low profile until the last decade. Within this period there has been a maturation of techniques for more accurate and sophisticated analyses of protein-surfactant complexes such as calorimetry and small angle scattering techniques. In this review I provide an overview of different useful approaches to study these complexes and identify eight different issues which define central concepts in the field. (1) Are proteins denatured by monomeric surfactant molecules, micelles or both? (2) How does unfolding of proteins in surfactant compare with "proper" unfolding in chemical denaturants? Recent work has highlighted the role of shared micelles, rather than monomers, below the critical micelle concentration (cmc) in promoting both protein denaturation and formation of higher order structures. Kinetic studies have extended the experimentally accessible range of surfactant concentrations to far above the cmc, revealing numerous different modes of denaturation by ionic surfactants below and above the cmc which reflect micellar properties as much as protein unfolding pathways. Uncharged surfactants follow a completely different denaturation strategy involving synergy between monomers and micelles. The high affinity of charged surfactants for proteins means that unfolding pathways are generally different in surfactants versus chemical denaturants, although there are common traits. Other issues are as follows: (3) Are there non-denaturing roles for SDS? (4) How reversible is unfolding in SDS? (5) How do solvent conditions affect the way in which surfactants denature proteins? The last three issues compare SDS with "proper" membranes. (6) Do anionic surfactants such as SDS mimic biological membranes? (7) How do mixed micelles interact with globular proteins? (8) How can mixed micelles be used to measure the stability of membrane proteins? The growing efforts to understand the unique features of membrane proteins have encouraged the development of mixed micelles to study the equilibria and kinetics of this class of proteins, and traits which unite globular and membrane proteins have also emerged. These issues emphasise the amazing power of surfactants to both extend the protein conformational landscape and at the same time provide convenient and reversible short-cuts between the native and denatured state for otherwise obdurate membrane proteins. © 2011 Elsevier B.V. All Rights Reserved.
Lysosomes and lysosomal cathepsins in cell deathUrška Repnik | Veronika Stoka | Vito Turk | Boris Turk
Volume 1824, Issue 1, January 2012, Pages 22-33
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by participating in the degradation of heterophagic and autophagic material. Following the targeted lysosomal membrane's destabilization, the cathepsins can be released into the cytosol and initiate the lysosomal pathway of apoptosis through the cleavage of Bid and the degradation of the anti-apoptotic Bcl-2 homologues. Cathepsins can also amplify the apoptotic signaling, when the lysosomal membranes are destabilized at a later stage of apoptosis, initiated by other stimuli. However, the functional integrity of the lysosomal compartment during apoptosis enables efficient autophagy, which can counteract apoptosis by providing the energy source and by disposing the damaged mitochondria, which generate the ROS. Impairing autophagy by disabling the lysosome function is being investigated as an adjuvant therapeutic approach to sensitize cells to apoptosis-inducing agents. Destabilization of the lysosomal membranes by the lysosomotropic detergents seems to be a promising strategy in this context as it would not only disable autophagy, but also promote apoptosis through the initiation of the lysosomal pathway. In contrast, the impaired autophagy and lysosomal degradation linked with the increased oxidative stress underlie degenerative changes in the aging neurons. This further suggests that lysosomes and lysosomal cathepsins have a dual role in cell death. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
Unusual biophysics of intrinsically disordered proteinsVladimir N. Uversky
Volume 1834, Issue 5, May 2013, Pages 932-951
Research of a past decade and a half leaves no doubt that complete understanding of protein functionality requires close consideration of the fact that many functional proteins do not have well-folded structures. These intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered protein regions (IDPRs) are highly abundant in nature and play a number of crucial roles in a living cell. Their functions, which are typically associated with a wide range of intermolecular interactions where IDPs possess remarkable binding promiscuity, complement functional repertoire of ordered proteins. All this requires a close attention to the peculiarities of biophysics of these proteins. In this review, some key biophysical features of IDPs are covered. In addition to the peculiar sequence characteristics of IDPs these biophysical features include sequential, structural, and spatiotemporal heterogeneity of IDPs; their rough and relatively flat energy landscapes; their ability to undergo both induced folding and induced unfolding; the ability to interact specifically with structurally unrelated partners; the ability to gain different structures at binding to different partners; and the ability to keep essential amount of disorder even in the bound form. IDPs are also characterized by the "turned-out" response to the changes in their environment, where they gain some structure under conditions resulting in denaturation or even unfolding of ordered proteins. It is proposed that the heterogeneous spatiotemporal structure of IDPs/IDPRs can be described as a set of foldons, inducible foldons, semi-foldons, non-foldons, and unfoldons. They may lose their function when folded, and activation of some IDPs is associated with the awaking of the dormant disorder. It is possible that IDPs represent the "edge of chaos" systems which operate in a region between order and complete randomness or chaos, where the complexity is maximal. This article is part of a Special Issue entitled: The emerging dynamic view of proteins: Protein plasticity in allostery, evolution and self-assembly. © 2012 Elsevier B.V.
Progress in tracing the evolutionary paths of cytochrome P450David R. Nelson
Volume 1814, Issue 1, January 2011, Pages 14-18
The state of cytochrome P450 sequence accumulation in different phyla is summarized. 12,456 P450s are currently named, with about 6000 more that are known, but not yet named. As the number of genomes sequenced moves from a few dozen to an inevitable few thousand, issues of nomenclature are discussed. Orthology will be the guiding principle for naming across related genomes such as vertebrates. Even if 1000 vertebrate genomes are sequenced there will still be only 19 CYP families in vertebrates. The variable clusters of genes in families CYP2, CYP3 and CYP4 may pose challenges for naming as 1:1 orthologs do not necessarily exist. The value of synteny across genomes is emphasized as a tool for deep time evolutionary studies of P450s in animals. There is evidence that macrosynteny may be useful in tracing the origin of animal CYP clans. The concept of saturation of sequence space is described and used to estimate how complete our knowledge is of P450s in different phyla. The special niche of filamentous fungal P450s acting in secondary metabolite gene clusters is discussed. From one quarter to one third of P450s in these fungi may be dedicated to these roles. © 2010 Elsevier B.V. All rights reserved.
An introduction to NMR-based approaches for measuring protein dynamicsIan R. Kleckner | Mark P. Foster
Volume 1814, Issue 8, August 2011, Pages 942-968
Proteins are inherently flexible at ambient temperature. At equilibrium, they are characterized by a set of conformations that undergo continuous exchange within a hierarchy of spatial and temporal scales ranging from nanometers to micrometers and femtoseconds to hours. Dynamic properties of proteins are essential for describing the structural bases of their biological functions including catalysis, binding, regulation and cellular structure. Nuclear magnetic resonance (NMR) spectroscopy represents a powerful technique for measuring these essential features of proteins. Here we provide an introduction to NMR-based approaches for studying protein dynamics, highlighting eight distinct methods with recent examples, contextualized within a common experimental and analytical framework. The selected methods are (1) Real-time NMR, (2) Exchange spectroscopy, (3) Lineshape analysis, (4) CPMG relaxation dispersion, (5) Rotating frame relaxation dispersion, (6) Nuclear spin relaxation, (7) Residual dipolar coupling, (8) Paramagnetic relaxation enhancement. This article is part of a Special Issue entitled: Protein Dynamics: Experimental and Computational Approaches. © 2010 Elsevier B.V. All rights reserved.
Proteases involved in cartilage matrix degradation in osteoarthritisLinda Troeberg | Hideaki Nagase
Volume 1824, Issue 1, January 2012, Pages 133-145
Osteoarthritis is a common joint disease for which there are currently no disease-modifying drugs available. Degradation of the cartilage extracellular matrix is a central feature of the disease and is widely thought to be mediated by proteinases that degrade structural components of the matrix, primarily aggrecan and collagen. Studies on transgenic mice have confirmed the central role of Adamalysin with Thrombospondin Motifs 5 (ADAMTS-5) in aggrecan degradation, and the collagenolytic matrix metalloproteinase MMP-13 in collagen degradation. This review discusses recent advances in current understanding of the mechanisms regulating expression of these key enzymes, as well as reviewing the roles of other proteinases in cartilage destruction. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
Cytochromes P450 are essential players in the vitamin D signaling systemInge Schuster
Volume 1814, Issue 1, January 2011, Pages 186-199
From earliest development on, the vitamin D receptor (VDR) is expressed in most cells of the mammalian body. The VDR is a nuclear, ligand-induced transcription factor that regulates in complex with hormonally active vitamin D the expression of more than 900 genes involved in a wide array of physiological functions (e.g. calcium homeostasis, growth control, differentiation, cognition, immune response, etc.). Accordingly, severe health problems are associated to vitamin deficiencies. Synthesis of the major active form 1α,25(OH) 2D3 from vitamin D and subsequent metabolism are exclusively controlled by specific P450-forms. Synthesis, a two-step process, starts with a 25-hydroxylation primarily by CYP2R1 (CYP27A1, CYP2J2, and CYP3A4 may also contribute) and a subsequent 1α-hydroxylation via CYP27B1. Circulating in the bloodstream, 1α,25(OH)2D3 acts at sites of VDR expression (target sites) in an endocrine way. However, it is also capable of autocrine/paracrine functions since various target tissues are fully competent in 1α,25(OH)2D3 synthesis, as illustrated by three examples. 1α,25(OH)2D3 levels are short-lived: the hormone upregulates its rapid metabolism by CYP24A1 that attacks repeatedly the vitamin D C20-27 side chain, thereby producing a complex cascade of transient metabolites with increasing polarity. Most of these metabolites still retain 1α,25(OH)2D3-like activities on the VDR, contributing to the overall effect that is commonly attributed to 1α,25(OH)2D3. As selective inhibitors of CYP24A1 increase the lifetime and thereby the function of vitamin D metabolites, they will help exploring whether and which intrinsic activities distinct metabolites possess. It appears likely that this strategy may unmask important regulators of new functions. © 2010 Elsevier B.V. All rights reserved.
P450s in plant-insect interactionsMary A. Schuler
Volume 1814, Issue 1, January 2011, Pages 36-45
Cytochrome P450 monooxygenases (P450s) are integral in defining the relationships between plants and insects. Secondary metabolites produced in plants for protection against insects and other organisms are synthesized via pathways that include P450s in many different families and subfamilies. Survival of insects in the presence of toxic secondary metabolites depends on their metabolism by more limited groups of P450s. Examples of functionally characterized plant and insect P450s known to be involved in these interactions are discussed in terms of their diversities, reactivities and regulators. These and future examples, which will be uncovered as the fields of plant biology and entomology converge on this interesting area, provide much insight into the array of plant metabolites that are mainline defenses against insects, the range of insect monooxygenases that inactivate these compounds and the evolutionary processes occurring as these organisms wage daily battles with one another. Molecular perspectives on these interactions will provide the scientific community with information critical for genetic manipulation of these organisms aimed at enhancing plant resistance to insects and eliminating insect resistance to natural plant toxins and synthetic insecticides. © 2010 Elsevier B.V. All rights reserved.
Cytochrome P450 enzymes in the fungal kingdomB. Črešnar | S. ̌ Petrič
Volume 1814, Issue 1, January 2011, Pages 29-35
Cytochrome P450 monooxygenases of fungi are involved in many essential cellular processes and play diverse roles. The enzymes catalyze the conversion of hydrophobic intermediates of primary and secondary metabolic pathways, detoxify natural and environmental pollutants and allow fungi to grow under different conditions. Fungal genome sequencing projects have enabled the annotation of several thousand novel cytochromes P450, many of which constitute new families. This review presents the characteristics of fungal cytochrome P450 systems and updates information on the functions of characterized fungal P450 monooxygenases as well as outlines the currently used strategies for determining the function of the many putative P450 enzymes. © 2010 Elsevier B.V. All rights reserved.
Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acidsAnne Konkel | Wolf Hagen Schunck
Volume 1814, Issue 1, January 2011, Pages 210-222
Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second messengers of various hormones and growth factors and play pivotal roles in the regulation of vascular, renal and cardiac function. As discussed in the present review, virtually all of the major AA metabolizing CYP isoforms accept a variety of other polyunsaturated fatty acids (PUFA), including linoleic, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), as efficient alternative substrates. The metabolites of these alternative PUFAs also elicit profound biological effects. The CYP enzymes respond to alterations in the chain-length and double bond structure of their substrates with remarkable changes in the regio- and stereoselectivity of product formation. The omega-3 double bond that distinguishes EPA and DHA from their omega-6 counterparts provides a preferred epoxidation site for CYP1A, CYP2C, CYP2J and CYP2E subfamily members. CYP4A enzymes that predominantly function as AA ω-hydroxylases show largely increased (ω-1)-hydroxylase activities towards EPA and DHA. Taken together, these findings indicate that CYP-dependent signaling pathways are highly susceptible to changes in the relative bioavailability of the different PUFAs and may provide novel insight into the complex mechanisms that link essential dietary fatty acids to the development of cardiovascular disease. © 2010 Elsevier B.V. All rights reserved.
Arthropod CYPomes illustrate the tempo and mode in P450 evolutionR. Feyereisen
Volume 1814, Issue 1, January 2011, Pages 19-28
The great diversity of P450 genes in a variety of organisms is well documented but not well explained. The number of CYP genes in each species is highly variable and this is shown here for arthropod, mainly insect CYPomes. Pairs of recognizable orthologs are but a small portion of the CYPome, but species- or lineage-specific expansions of CYP subfamilies are consistently observed. These "blooms" of CYP genes have their origin in multiple gene duplications, although some subfamilies expand and others do not. Stochastic birth and death models of CYP gene proliferation are sufficient to explain blooms, and speciation events may play important roles in CYPome diversity between lineages. Mitochondrial clan P450s are a monophyletic group of genes that has seen several blooms in insects, but apparently not in vertebrates. © 2010 Elsevier B.V. All rights reserved.
Calpains - An elaborate proteolytic systemYasuko Ono | Hiroyuki Sorimachi
Volume 1824, Issue 1, January 2012, Pages 224-236
Calpain is an intracellular Ca 2+-dependent cysteine protease (EC 18.104.22.168; Clan CA, family C02). Recent expansion of sequence data across the species definitively shows that calpain has been present throughout evolution; calpains are found in almost all eukaryotes and some bacteria, but not in archaebacteria. Fifteen genes within the human genome encode a calpain-like protease domain. Interestingly, some human calpains, particularly those with non-classical domain structures, are very similar to calpain homologs identified in evolutionarily distant organisms. Three-dimensional structural analyses have helped to identify calpain's unique mechanism of activation; the calpain protease domain comprises two core domains that fuse to form a functional protease only when bound to Ca 2+ via well-conserved amino acids. This finding highlights the mechanistic characteristics shared by the numerous calpain homologs, despite the fact that they have divergent domain structures. In other words, calpains function through the same mechanism but are regulated independently. This article reviews the recent progress in calpain research, focusing on those studies that have helped to elucidate its mechanism of action. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
PKA: Lessons learned after twenty yearsSusan S. Taylor | Ping Zhang | Jon M. Steichen | Malik M. Keshwani | Alexandr P. Kornev
Volume 1834, Issue 7, May 2013, Pages 1271-1278
The first protein kinase structure, solved in 1991, revealed the fold that is shared by all members of the eukaryotic protein kinase superfamily and showed how the conserved sequence motifs cluster mostly around the active site. This structure of the PKA catalytic (C) subunit showed also how a single phosphate integrated the entire molecule. Since then the EPKs have become a major drug target, second only to the G-protein coupled receptors. Although PKA provided a mechanistic understanding of catalysis that continues to serve as a prototype for the family, by comparing many active and inactive kinases we subsequently discovered a hydrophobic spine architecture that is a characteristic feature of all active kinases. The ways in which the regulatory spine is dynamically assembled is the defining feature of each protein kinase. Protein kinases have thus evolved to be molecular switches, like the G-proteins, and unlike metabolic enzymes which have evolved to be efficient catalysis. PKA also shows how the dynamic tails surround the core and serve as essential regulatory elements. The phosphorylation sites in PKA, introduced both co- and post-translationally, are very stable. The resulting C-subunit is then packaged as an inhibited holoenzyme with cAMP-binding regulatory (R) subunits so that PKA activity is regulated exclusively by cAMP, not by the dynamic turnover of an activation loop phosphate. We could not understand activation and inhibition without seeing structures of R:C complexes; however, to appreciate the structural uniqueness of each R2:C2 holoenzyme required solving structures of tetrameric holoenzymes. It is these tetrameric holoenzymes that are localized to discrete sites in the cell, typically by A Kinase Anchoring Proteins where they create discrete foci for PKA signaling. Understanding these dynamic macromolecular complexes is the challenge that we now face. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012). © 2013 Elsevier B.V.
HOmer Kabil | Nicole Motl | Ruma Banerjee
2S and its role in redox signaling
Volume 1844, Issue 8, January 2014, Pages 1355-1366
Hydrogen sulfide (H2S) has emerged as an important gaseous signaling molecule that is produced endogenously by enzymes in the sulfur metabolic network. H2S exerts its effects on multiple physiological processes important under both normal and pathological conditions. These functions include neuromodulation, regulation of blood pressure and cardiac function, inflammation, cellular energetics and apoptosis. Despite the recognition of its biological importance and its beneficial effects, the mechanism of H2S action and the regulation of its tissue levels remain unclear in part owing to its chemical and physical properties that render handling and analysis challenging. Furthermore, the multitude of potential H2S effects has made it difficult to dissect its signaling mechanism and to identify specific targets. In this review, we focus on H2S metabolism and provide an overview of the recent literature that sheds some light on its mechanism of action in cellular redox signaling in health and disease. This article is part of a Special Issue entitled: Thiol-Based Redox Processes. © 2014 Elsevier B.V.
Protein stability, flexibility and functionKaare Teilum | Johan G. Olsen | Birthe B. Kragelund
Volume 1814, Issue 8, August 2011, Pages 969-976
Proteins rely on flexibility to respond to environmental changes, ligand binding and chemical modifications. Potentially, a perturbation that changes the flexibility of a protein may interfere with its function. Millions of mutations have been performed on thousands of proteins in quests for a delineation of the molecular details of their function. Several of these mutations interfered with the binding of a specific ligand with a concomitant effect on the stability of the protein scaffold. It has been ambiguous and not straightforward to recognize if any relationships exist between the stability of a protein and the affinity for its ligand. In this review, we present examples of proteins where changes in stability results in changes in affinity and of proteins where stability and affinity are uncorrelated. We discuss the possibility for a relationship between stability and binding. From the data presented is it clear that there are specific sites (flexibility hotspots) in proteins that are important for both binding and stability. This article is part of a Special Issue entitled: Protein Dynamics: Experimental and Computational Approaches. © 2010 Elsevier B.V. All rights reserved.
Catalytic mechanisms for phosphotriesterasesAndrew N. Bigley | Frank M. Raushel
Volume 1834, Issue 1, January 2013, Pages 443-453
Phosphotriesters are one class of highly toxic synthetic compounds known as organophosphates. Wide spread usage of organophosphates as insecticides as well as nerve agents has lead to numerous efforts to identify enzymes capable of detoxifying them. A wide array of enzymes has been found to have phosphotriesterase activity including phosphotriesterase (PTE), methyl parathion hydrolase (MPH), organophosphorus acid anhydrolase (OPAA), diisopropylfluorophosphatase (DFP), and paraoxonase 1 (PON1). These enzymes differ widely in protein sequence and three-dimensional structure, as well as in catalytic mechanism, but they also share several common features. All of the enzymes identified as phosphotriesterases are metal-dependent hydrolases that contain a hydrophobic active site with three discrete binding pockets to accommodate the substrate ester groups. Activation of the substrate phosphorus center is achieved by a direct interaction between the phosphoryl oxygen and a divalent metal in the active site. The mechanistic details of the hydrolytic reaction differ among the various enzymes with both direct attack of a hydroxide as well as covalent catalysis being found. This article is part of a Special Issue entitled: Chemistry and mechanism of phosphatases, diesterases and triesterases. © 2012 Elsevier B.V. All rights reserved.
PLP-dependent H 2S biogenesisSangita Singh | Ruma Banerjee
Volume 1814, Issue 11, November 2011, Pages 1518-1527
The role of endogenously produced H 2S in mediating varied physiological effects in mammals has spurred enormous recent interest in understanding its biology and in exploiting its pharmacological potential. In these early days in the field of H 2S signaling, large gaps exist in our understanding of its biological targets, its mechanisms of action and the regulation of its biogenesis and its clearance. Two branches within the sulfur metabolic pathway contribute to H 2S production: (i) the reverse transsulfuration pathway in which two pyridoxal 5′-phosphate-dependent (PLP) enzymes, cystathionine β-synthase and cystathionine γ-lyase convert homocysteine successively to cystathionine and cysteine and (ii) a branch of the cysteine catabolic pathway which converts cysteine to mercaptopyruvate via a PLP-dependent cysteine aminotransferase and subsequently, to mercaptopyruvate sulfur transferase-bound persulfide from which H 2S can be liberated. In this review, we present an overview of the kinetics of the H 2S-generating reactions, compare the structures of the PLP-enzymes involved in its biogenesis and discuss strategies for their regulation. This article is part of a Special Issue entitled: Pyridoxal Phospate Enzymology. © 2011 Elsevier B.V. All rights reserved.
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targetingAaron Ciechanover
Volume 1824, Issue 1, January 2012, Pages 3-13
Between the 1950s and 1980s, scientists were focusing mostly on how the genetic code was transcribed to RNA and translated to proteins, but how proteins were degraded had remained a neglected research area. With the discovery of the lysosome by Christian de Duve it was assumed that cellular proteins are degraded within this organelle. Yet, several independent lines of experimental evidence strongly suggested that intracellular proteolysis was largely non-lysosomal, but the mechanisms involved have remained obscure. The discovery of the ubiquitin-proteasome system resolved the enigma. We now recognize that degradation of intracellular proteins is involved in regulation of a broad array of cellular processes, such as cell cycle and division, regulation of transcription factors, and assurance of the cellular quality control. Not surprisingly, aberrations in the system have been implicated in the pathogenesis of human disease, such as malignancies and neurodegenerative disorders, which led subsequently to an increasing effort to develop mechanism-based drugs. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
Native ion mobility-mass spectrometry and related methods in structural biologyA. Konijnenberg | A. Butterer | F. Sobott
Volume 1834, Issue 6, June 2013, Pages 1239-1256
Mass spectrometry-based methods have become increasingly important in structural biology - in particular for large and dynamic, even heterogeneous assemblies of biomolecules. Native electrospray ionization coupled to ion mobility-mass spectrometry provides access to stoichiometry, size and architecture of noncovalent assemblies; while non-native approaches such as covalent labeling and H/D exchange can highlight dynamic details of protein structures and capture intermediate states. In this overview article we will describe these methods and highlight some recent applications for proteins and protein complexes, with particular emphasis on native MS analysis. This article is part of a Special Issue entitled: Mass spectrometry in structural biology. © 2012 Elsevier B.V.
Serine racemase and the serine shuttle between neurons and astrocytesHerman Wolosker
Volume 1814, Issue 11, November 2011, Pages 1558-1566
d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5′-phosphate-dependent enzyme. In addition to carry out racemization, SR α,β-eliminates water from l- or d-serine, generating pyruvate and NH 4+. Here I review the main mechanisms regulating SR activity and d-serine dynamics in the brain. I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. d-Serine synthesized and released by neurons can be further taken up by astrocytes for storage and activity-dependent release. I discuss how SR α,β-elimination with d-serine itself may limit the achievable intracellular d-serine concentration, providing a mechanistic rationale on why neurons do not store as much d-serine as astrocytes. The higher content of d-serine in astrocytes appears to be related to increased d-serine stability, for their low SR expression will prevent substantial d-serine metabolism via α,β-elimination. SR and the serine shuttle pathway are therapeutic targets in neurodegenerative diseases in which NMDA receptor dysfunction plays pathological roles. This article is part of a Special Issue entitled: Pyridoxal Phospate Enzymology. © 2011 Elsevier B.V. All rights reserved.
Proliferative versus apoptotic functions of caspase-8: Hetero or homo: The caspase-8 dimer controls cell fateBram J. Van Raam | Guy S. Salvesen
Volume 1824, Issue 1, January 2012, Pages 113-122
Caspase-8, the initiator of extrinsically-triggered apoptosis, also has important functions in cellular activation and differentiation downstream of a variety of cell surface receptors. It has become increasingly clear that the heterodimer of caspase-8 with the long isoform of cellular FLIP (FLIP L) fulfills these pro-survival functions of caspase-8. FLIP L, a catalytically defective caspase-8 paralog, can interact with caspase-8 to activate its catalytic function. The caspase-8/FLIP L heterodimer has a restricted substrate repertoire and does not induce apoptosis. In essence, caspase-8 heterodimerized with FLIP L prevents the receptor interacting kinases RIPK1 and -3 from executing the form of cell death known as necroptosis. This review discusses the latest insights in caspase-8 homo- versus heterodimerization and the implication this has for cellular death or survival. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome. © 2011 Elsevier B.V. All rights reserved.
Breakthrough in P450 bioelectrochemistry and future perspectivesSheila J. Sadeghi | Andrea Fantuzzi | Gianfranco Gilardi
Volume 1814, Issue 1, January 2011, Pages 237-248
Improving the electrochemical performance of cytochrome P450 enzymes is highly desirable due to their versatility in the recognition of different biological and xenobiotic compounds. The task poses an exciting challenge because it leads not only to the acquisition of fundamental knowledge on the redox properties of these enzymes, but it also opens opportunities for technological and commercial applications. Interfacing these enzymes to electrode surfaces and electrochemically driving their catalytic cycle has proven to be very difficult. Initial attempts made by several groups included the direct immobilisation of these enzymes on electrode surfaces and omission of their redox partners for simplification of their electron transfer pathway. The data obtained in these cases generally resulted in a high heterogeneous electron transfer rate but without success in terms of detectable substrate turnover. The breakthrough in electrocatalysis has been made when both the electrode and the enzyme have been engineered, in some cases mimicking the natural environment of the microsomal enzymes and the inclusion of their electron transfer partners. This paper reviews and discusses the recent literature on this subject, and highlights the different approaches that have led to an unprecedented advancement of this area of research. © 2010 Elsevier B.V. All rights reserved.
Protein disorder, prion propensities, and self-organizing macromolecular collectivesLiliana Malinovska | Sonja Kroschwald | Simon Alberti
Volume 1834, Issue 5, May 2013, Pages 918-931
Eukaryotic cells are partitioned into functionally distinct self-organizing compartments. But while the biogenesis of membrane-surrounded compartments is beginning to be understood, the organizing principles behind large membrane-less structures, such as RNA-containing granules, remain a mystery. Here, we argue that protein disorder is an essential ingredient for the formation of such macromolecular collectives. Intrinsically disordered regions (IDRs) do not fold into a well-defined structure but rather sample a range of conformational states, depending on the local conditions. In addition to being structurally versatile, IDRs promote multivalent and transient interactions. This unique combination of features turns intrinsically disordered proteins into ideal agents to orchestrate the formation of large macromolecular assemblies. The presence of conformationally flexible regions, however, comes at a cost, for many intrinsically disordered proteins are aggregation-prone and cause protein misfolding diseases. This association with disease is particularly strong for IDRs with prion-like amino acid composition. Here, we examine how disease-causing and normal conformations are linked, and discuss the possibility that the dynamic order of the cytoplasm emerges, at least in part, from the collective properties of intrinsically disordered prion-like domains. This article is part of a Special Issue entitled: The emerging dynamic view of proteins: Protein plasticity in allostery, evolution and self-assembly. © 2013 Elsevier B.V.
Vitamin BMartino Luigi Di Salvo | Roberto Contestabile | Martin K. Safo
6 salvage enzymes: Mechanism, structure and regulation
Volume 1814, Issue 11, November 2011, Pages 1597-1608
Vitamin B 6 is a generic term referring to pyridoxine, pyridoxamine, pyridoxal and their related phosphorylated forms. Pyridoxal 5′-phosphate is the catalytically active form of vitamin B 6, and acts as cofactor in more than 140 different enzyme reactions. In animals, pyridoxal 5′-phosphate is recycled from food and from degraded B 6-enzymes in a "salvage pathway", which essentially involves two ubiquitous enzymes: an ATP-dependent pyridoxal kinase and an FMN-dependent pyridoxine 5′-phosphate oxidase. Once it is made, pyridoxal 5′-phosphate is targeted to the dozens of different apo-B 6 enzymes that are being synthesized in the cell. The mechanism and regulation of the salvage pathway and the mechanism of addition of pyridoxal 5′-phosphate to the apo-B 6-enzymes are poorly understood and represent a very challenging research field. Pyridoxal kinase and pyridoxine 5′-phosphate oxidase play kinetic roles in regulating the level of pyridoxal 5′-phosphate formation. Deficiency of pyridoxal 5′-phosphate due to inborn defects of these enzymes seems to be involved in several neurological pathologies. In addition, inhibition of pyridoxal kinase activity by several pharmaceutical and natural compounds is known to lead to pyridoxal 5′-phosphate deficiency. Understanding the exact role of vitamin B 6 in these pathologies requires a better knowledge on the metabolism and homeostasis of the vitamin. This article summarizes the current knowledge on structural, kinetic and regulation features of the two enzymes involved in the PLP salvage pathway. We also discuss the proposal that newly formed PLP may be transferred from either enzyme to apo-B 6-enzymes by direct channeling, an efficient, exclusive, and protected means of delivery of the highly reactive PLP. This new perspective may lead to novel and interesting findings, as well as serve as a model system for the study of macromolecular channeling. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology. © 2010 Elsevier B.V. All rights reserved.


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Perth Ambassador Hotel
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TravelPod Member ReviewsPerth Ambassador Hotel
A nice well kept older hotel near enough to the CBD and water front to make all walkable. Very quick access to public transportation to airport.
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Caversham Wildlife Park
... viewing the photos of this blog entry, most will agree that the owls were among the most fascinating animals at the Park (although the bats freaked me out, too). We had the opportunity to feed kangaroos, get up close to the koalas, and meet wombats for the first time! It was good fun for the whole family.
An interesting side note, while we were walking around the Park we ran into a family we know from Dubai! Their daughter is one of ...
Leaving Perth for another adventure
Finally packed after much dilemma on what to take and probably too much...........but Challenge has been the weather - here in Perth it is beautiful 25 - St. Bess is 12 maybe showers, maybe sunshine - prayers to the trekking gods for good weather. Lisa picked me up and off to the airport. We celebrated with a champers, said our goodbyes and so my journey ...


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- Chest pain
- Shortness of breath
What causes chest pain and shortness of breath? 52 possible conditions
See a list of possible causes in order from the most common to the least.
This condition is considered a medical emergency. Urgent care may be required.
A clot blocks the blood flow to the heart (heart attack), and damages heart muscle. Symptoms include chest pain, shortness of breath, and a blue or grey tinge to the skin.
Lung cancer is a cancer that originates in the lungs. Lung cancer often goes undetected in the early stages, since symptoms don't usually present themselves until the advanced stages of the disease.
This condition is considered a medical emergency. Urgent care may be required.
An abnormal heart rhythm is when your heart beats too fast, slow, or irregularly. This is also called an arrhythmia. Within the heart is a complex system of valves, nodes, and chambers that control how and when th...
Learn about the causes and treatment of acute bronchitis.
Hypertensive heart disease refers to heart conditions caused by high blood pressure. Possible signs of acute hypertension include sweating and chills.
High blood pressure (hypertension) increases your risk for heart attack, stroke, coronary heart disease, and other serious health problems.
Cor pulmonale is a condition that most commonly arises out of complications from high blood pressure.
Costochondritis an inflammation of the cartilage in the rib cage. Learn about costochondritis symptoms, causes, diagnosis, and treatment.
Congestive cardiomyopathy, also known as dilated cardiomyopathy, is characterized by a weak primary pumping chamber in the heart. Your heart automatically attempts to correct for this inefficiency. In turn, thi...
This condition is considered a medical emergency. Urgent care may be required.
A pulmonary embolism is a blood clot that occurs in the lungs. It can damage part of the lung and other organs and decrease oxygen levels in the blood.
Rheumatic fever is a complication of strep throat. If it's left untreated, it can cause permanent damage to your heart. Find out about symptoms and treatment.
Hypertrophic cardiomyopathy is a condition in which your heart muscle is thicker than normal. It can interfere with your heart's ability to pump blood.
Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs. Read more on whom it affects and how to treat it.
CAD occurs when one or more of the coronary arteries begin to narrow due to the build-up of cholesterol and plaque. The blockage of one of these arteries leads to a heart attack.
Ischemic cardiomyopathy (IC) is a condition that occurs when the heart muscle is weakened. It's usually caused by heart attack or coronary artery disease.
Pericarditis is the inflammation of the sac that surrounds your heart. The sac is a double-layered membrane called the pericardium. The pericardium protects your heart and helps it function properly.Pericarditis can b...
Myocarditis is inflammation of the heart muscle. It is a rare condition that can be caused by any number of autoimmune diseases, viral, bacterial, or fungal infections, or parasites. When you have an infection or a...
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Mass. teen arrested on I91, found with drugs and alcoholNovember 17,2012ROYALTON — Vermont State Police say a Massachusetts teenager was found to have both alcohol and a number of drugs Friday.
State police say they pulled over Johnpeter Hegeman, 19, for a minor traffic violation on I-89 southbound. After an investigation, they said they found Hegeman to be in possession of alcohol, amphetamines, Xanax, marijuana, and MDMA, widely known as ecstasy.
Hegemen is scheduled to appear in Windsor County criminal court on Jan. 8 to answer the five possession offenses.MORE IN This Just InCity officials are hoping to get a lot more money to spend on firetrucks. Full StoryWHITE RIVER JUNCTION A Rutland man is charged with aggravated domestic assault with a deadly... Full StoryWARDSBORO Vermont State Police said Friday that Kirby Staib of Wardsboro, who was allegedly... Full Story
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Saint-Martin-de-la-Place Things to Do
Chateau de Boumois
From Saumur there's a 6 km long secundary road (back road) called Rue du Boumois and it leads to a little chateau. It looked quiet and empty but with plenty of parking space, indicating it must be quite well visited.
As it happened, we were there at the wrong time, it was closed during the lunch break.
Architecturally it is interesting as it shows the change from gothic to early renaissance.
The link below can be translated into English, using the google link at the bottom left.
Overall, a visit takes an hour, English, German and French is spoken.
Opening times and admission fees are all mentioned on the webpage.Related to:
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Saint-Martin-de-la-Place Hotels
Domaine De La Blairie
This is a very nice hotel, suitable for seniors and families alike. Plenty of ground and shaded area...more
Saint-Martin-de-la-Place Warnings and Dangers
What's a German warning doing here?
We came across this funny sign in German. It reads:
Vorsicht, freilaufende Hunde ausser Besichtingungsperiode.
Wann Hunde kommen, flach auf den Boden legen und auf Hilfe warten. Viel Gluck
That means: outside opening hours there are dogs on the loose. When dogs come, lie flat on the ground and wait for help. Good luck!
That must be a joke. And if not, you know what to do!
Which reminds me... this wasn't in Saumur. It was just outside Saumur on the north river bank of the Loire at a small chateau. I'll look up the name...Related to:
- Castles and Palaces
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Local Motion: Michelle Amiott and Elaine Brett
By Travis Bubenik • Sep 10, 2013
Today on Local Motion we speak with two people working to promote healthy lifestyles and diets in western Colorado.
Michelle Amiott is a new AmeriCorps Vista for both LiveWell Montrose-Olathe and the Valley Food Partnership (VFP.) Elaine Brett is on the Steering Committee for the VFP, and founded the organization's earlier incarnation - the Western Colorado Food & Agriculture Council.


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'Doctor Who' episodes materialize on Facebook
'Doctor Who' fans can now get their Gallifrey fix on Facebook.
BBC Worldwide announced today that nine episodes are available through the social network starring nine of the Doctor's 11 incarnations. Each remastered story has multiple episodes, and one, "The Greatest Show in the Galaxy" starring Sylvester McCoy as the Doctor is available only on Facebook. The shows are accessible through the Doctor Who Facebook page for 15 Facebook credits -- about $1.50 -- which grants 48 hours to watch the story. I've seen all but the McCoy episode offered in this group, and they are all worth watching, especially "The Time Warrior," "Tomb of the Cybermen," "Attack of the Cybermen," "City of Death" and "Silence in the Library."
The sixth and current season of modernized Doctor Who reboot is currently on hiatus and returns in September.
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