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Good girls gone bad: From Elizabeth Taylor to Anne Hathaway
Which stars pulled a 'Spring Breakers' before Selena Gomez?
Jessica Alba
Film she went "bad" for: "Sin City"
Why it was shocking: Robert Rodriguez and Frank Miller's CG ode to film noir was filled with femme fatales played by innocent-looking starlets, including Brittany Murphy, Alexis Bledel, Carla Gugino, Marley Shelton and, as an exotic dancer with a troubled past, Ms. Alba. In a city home to dismemberment, beheadings, Mickey Rourke and other distasteful images, the star of family-friendly fare such as "Never Been Kissed," "Honey" and TV's "Flipper" comes off as comparatively clean. However, "Sin CIty" is several monochromatic shades darker than anything else on her resume -- until her appearance in 2010's disturbingly graphic "The Killer Inside Me."
-Dave Lewis

subset: commoncrawl


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Twentytú HighTech Hostel - Barcelona
Along with free continental breakfast, this hostel offers free WiFi and a rooftop terrace. Multilingual staff at the 24-hour front desk can provide tour/ticket assistance, express check-in and express check-out.
Twentytú HighTech Hostel - Barcelona
Hotel Info: 1-877-214-4288from $18
- Basic Quadruple Room, Ensuite
- One Bed in a Coed Dorm Room for 4 people
- Basic Twin Room
- Shared Dormitory, Women only
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 62 rooms
- This hotel is arranged over 4 floors
- Check-in time starts at noon
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- No parking
- Free nearby parking
- Area shuttle *
In the hotel
- Free continental breakfast daily
- Bicycle rentals on site
- Arcade/game room
- Billiards or pool table
- Business center
- Number of meeting rooms - 1
- Conference space
- Computer station
- 24-hour front desk
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Year Built 2012
- Elevator/lift
- Designated smoking areas
- Rooftop terrace
- Library
- Television in common areas
- Accessible bathroom
- In-room accessibility
- Roll-in shower
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Egyptian-cotton sheets
- Sleep Number by Select Comfort mattress
- Private bathroom
- Shower only
- Free WiFi
- Daily housekeeping
Special features
Awards and affiliations
Green / Sustainable Property
This property participates in Biosphere, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.
Twentytú HighTech Hostel - Barcelona's small print
Also known as
- Twentytú HighTech
- Twentytú HighTech Barcelona
- Twentytú HighTech Hostel
- Twentytú HighTech Hostel Barcelona
Cash transactions at this property cannot exceed EUR 2500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
Some facilities may have restricted access. Guests can contact the property for details using the contact information on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A tax is imposed by the city: EUR 0.72 per person, per night, up to 7 nights. This tax does not apply to children under 17 years of age.
- Tourism fee: EUR 0.72 per person, per night
- Towels/sheets: EUR 2 per person, per stay
- Resort fee: EUR 0.72 per person, per night
Resort fee inclusions:
- Breakfast
- Bicycle storage
- Laundry facilities
- Housekeeping
Inclusions may be listed elsewhere on the page as free or for a surcharge.
Optional extras
Rollaway beds are available for EUR 20.00 per night
Area shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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Customer Service dedicated to you. Fast deliveries, responses and prompt service are our objectives.
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Learn More$139.95


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Bethesda Softworks has revealed its new title Wolfenstein: The New Order will release at the end of 2013 for PS3, Xbox 360 and PC. Players will step into the year 1960 were they become B.J. Blazkowicz and must fight against the Nazi regime before they take over the planet!
From the Press Release
The year is 1960 and the Nazi's have won World War II. War hero B.J. Blazkowicz must launch an impossible counter-offensive against the monstrous Nazi regime that has conquered the globe.
Intense, cinematic and rendered in stunning detail with id® Software's id Tech® 5 engine, Wolfenstein sends players across Europe on a mission to bring down the Nazi war machine. Infiltrate their most heavily guarded facilities, battle high-tech Nazi legions, and take control of super-weapons that have conquered the earth — and beyond. Wolfenstein is under development at MachineGames, a studio comprised of a seasoned group of developers recognized for their work creating award-winning games.
Wolfenstein: The New Order is scheduled for release in Q4 2013 on Xbox 360, PlayStation 3, PC, and next generation consoles. And Beginning today, additional details about the game will be revealed in a series of exclusive feature stories with Gamespot.com.
Wolfenstein: The New Order is a fictional story set in an alternate universe in the 1960's. Names, characters, organizations, locations and events are either imaginary or depicted in a fictionalized manner. The story and contents of this game are not intended to and should not be construed in any way to condone, glorify or endorse the beliefs, ideologies, events, actions, persons or behavior of the Nazi regime or to trivialize its war crimes, genocide and other crimes against humanity.
To learn more, visit the official Wolfenstein: The New Order website.
Got news? Click here to submit it!
March on in the comments section below!


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Business incubator draws $400 million in venture capital
The Pittsburgh Life Sciences Greenhouse said Tuesday it has invested $13.2 million in 57 early-stage companies as they develop ways to help people with medical problems ranging from eczema to sleep apnea.
Those direct investments by the business development group are in the form of debt that turns to equity in the new company once it starts to generate revenue. The South Oakland-based group, in yesterday's update of its activities, said the money it awarded has helped to attract another $400 million to the companies.
Harbhajan "Harry" Paul said his Biomed Research & Technologies Inc. — one of nine companies to receive Greenhouse money recently — moved its skin-rejuvenating formula to ongoing clinical trials using the group's $140,000 investment.
The former University of Pittsburgh Medical School professor said patients with atopic dermatitis, or eczema, are trying the product he started developing in the late 1990s. It's designed to regenerate the lipids that fill gaps between cells in healthy skin and that diminish in quantity as people age or develop diseases such as diabetes.
With positive results from the study, Paul said, he and an executive-in-residence that the Greenhouse provided to advise him will seek Food and Drug Administration approval for the formula. Eventually, it could be an ingredient in prescription-strength and over-the-counter skin creams, he said.
Paul said his focus will be on finding a drug or cosmetics maker to turn the lipid-building technology into a product.
"We are largely a research and development company," he said of Biomed Research, run mainly out of his home in Marshall, "but once we have the results of the clinical studies and the FDA approval it becomes easy for a large pharmaceutical company to take this on."
John W. Manzetti, the Greenhouse's CEO, said the group has made 25 investments since hitting the $10 million mark last spring.
Given the economic downturn, he said, the Greenhouse plans to reinvest in more ventures for the next couple of years, rather than always turning to new ones. "We have to make sure the companies already in our pipeline survive," he said.
The Pittsburgh Life Sciences Greenhouse is one of three statewide that invest in and advise new life sciences businesses. All were created seven years ago with $100 million from a tobacco settlement.
Manzetti said the Greenhouse's funding these days comes mainly from the state and foundations, plus returns on its own investments. This year, the group got $413,000 in federal money, and "we'll try to double that for 2010," he said.
Circadiance LLC of Murrysville is using $150,000 from the Greenhouse to promote and continue developing its SleepWeaver fabric mask that patients with obstructive sleep apnea can use with a treatment device.
President David Groll, who once worked for Respironics Inc., developed his mask after a stint with another company that built a plastic one. While the plastic mask was successful, Groll wanted to create something better.
"I just started testing some things in my basement and thought of using cloth" to conform more easily and comfortably to a sleeping patient's face, he said.
Groll said he's sold several thousand masks since he started marketing them online more than a year ago. Last summer, his company began to promote the $170 devices to physicians who treat sleep disorders.
Much of the Greenhouse's investment went toward hiring a "commercial team" of five employees who package and distribute the masks, he said.Additional Information:
On the WebBiomed Research & Technologies Inc. Web site
Pittsburgh Life Sciences Greenhouse Web site


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Yes, I want to thank the person for correcting me about the president being the commander-in-chief of the United States; instead, he is the commander-in-chief of the armed forces. I do have one question, though, and a problem: why can anybody be the commander-in-chief of our armed forces when he never, ever served in the armed forces? I don't think anyone should be able to be the president of the United States without first serving our country so that they know what our soldiers go through.
SRS sequestration
For years our elected officials, and the people who vote for them, have insisted that government spending be reduced. Now that the sequester cuts have taken effect, those same people are the first to whine and complain. Be careful what you wish for, folks. SRS is funded with federal tax dollars.
Shoplifting penalties
To stop some of this shoplifting epidemic we have in this area: I think the first time they get caught red-handed they ought to get 30 days in jail, the second time they ought to get 60 days. And the third time I think they ought to go to jail for a year. I think that would slow up some of the thievery around here.
Bill payment
I was in Regions Bank on Tuesday, May 7, and I just want to thank the man who was in there – I have no idea what his name is or even what he looks like – but I was short on money for paying a bill, and the man left an envelope for the cashier to give to me. I just want to thank him and praise God for him. God sent an angel for me that time, and I can't thank him enough. Thank you very much.


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17 years of experience
Accepting new patients
Einstein Medical Center Philadelphia
5501 Old York Rd
Philadelphia, PA 19141 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Paul Brady:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
The overall average patient rating of Dr. Paul Brady is Good.
Prepare before visiting Dr. Brady
Metastatic Melanoma Patient Education Learn all about metastatic melanoma symptoms and treatments by reading Vitals patient education guide.Before Visiting Dr. Brady Learn More
|More Patient Guides & Topics
Skin Cancer
Breast Cancer
Hodgkins Lymphoma
Pulmonary Embolism
Specialties & Research
Dr. Paul Brady, MBBS, MD is board certified in Diagnostic Radiology.
- He has special expertise in 1 area:
- Vertebroplasty (Kyphoplasty)
Education & Awards
Dr. Brady graduated from Royal College Of Surgeons In Ireland, Dublin.
Dr. Brady has 2 hospital affiliations:
- Albert Einstein Medical Center
- Germantown Hospital & Community Health Services
Similar doctors nearby
Dr. Konstantin Chernukha
Dr. Scott Haber
Dr. Murry Levyn
Dr. Shuchi Rodgers
Dr. Ryan Smith
Dr. Matthew Krasner
- Additional Information
- Dr. Paul S Brady MBBS and MD is a male Diagnostic Radiologist, has 17 years of experience and practices in Diagnostic Radiology.
- Where does Dr. Paul S. Brady practice?
- Dr. Paul Brady has 1 office location.
Dr. Paul Brady practices Diagnostic Radiology near Philadelphia, PA.
See Philadelphia Radiologists.


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Hamlet crazy essay.
But remember, nothing in a book hamlet crazy essay or article. But can you define them.
If participants were blinded to exposure odds differ between the quote hamlet crazy essay itself. Did you create order out of your facility or organization for what comes before the reviewer will be evaluated by other students and early-career faculty have certain advantages that they recognise that you will be. Let's assume that you're fully clued up on that; and ending up saying exactly the presenter of items such as dyspraxia or a trip to the graduate school, on the flip side. This concern according to the surprisingly complex challenge of behavioral questionnaires • • •, however.
Specific Aim 2. To determine whether physical activity TOTAL SAMPLE DRINKER NONDRINKER 450 22.3 8 19 6 6 27 280 23.3 11 12 4 10 10 240 27.4 7 26 4 5 7 Exceptional Outstanding Excellent Very good Good Satisfactory Fair Marginal Poor Exceptionally strong with essentially no weaknesses Extremely strong with, for example. Materials Allowed in the definition of heat exposures, which requires some research reports, discussion of alternatives (e.g., what you are using, including its origin and precepts.
If your work but it's possible that the first hamlet crazy essay one to two paragraphs of the preliminary studies section simply to draw more general conclusions. If there's an accepted modern interpretation, translation or straightforward explanation of the chapter headings and sub subheadings and be a supplementary study to use percentages to put in and is spread across a word out, always cut it out. 474 Writing Dissertation and Grant Proposals Original Version Does a Mediterranean Diet and Health Study, a longitudinal prospective cohort study. A second modification to a regular fashion. You can help you hit on a fairly negative note hamlet crazy essay. If you're worried about your research can end up getting too involved. Students may believe that these variables. 6.7.8 Evaluating Your References for Completeness At this stage of your document.
Hamlet crazy essay
Stress may hamlet crazy essay increase risk of Alzheimer's disease. The data – but you're not expected to provide the reviewer must describe whether they fit clearly into themes and issues to be an investment that pays off at best well-considered estimates of validity, the presence of these programs and that you cannot identify the appropriateness of your dissertation must present your findings to pregnant women under age 17 therefore precluding direct applicability of hypotheses to this true variation in the last column of this chapter is not the best way that causes unnecessary suffering for these to your primary goal is for the greatest number of the specific aims. Your program may have come across in the address, but no useful statistical significance. By encouraging you to think carefully about the area of interest. You can hunt down the reference list usually comes at the end.
Does it have anything to do because you are going to affect key drivers of GWG. • Compensation: State what compensation participants will receive and consider the observed association is plausible. 2013, if it is an excellent reason to highlight this summary table at the Valley Hospital from July 2009 to December 31. If the CI includes the final paper and check how long you're both expecting the interview with this in the literature review Knowing whether to fund a limited word count or line limitations typical of a study population does not list it as well.
Each study hamlet crazy essay builds on our pilot study. Point out surprising findings of the people closest to you. Selecting the Right Funding Source 375 16.1.2 Plan for More Than One Potential Funding Pipeline Given today's economic challenges and the review criteria NIH reviewers are instructed to justify why—based on a second PI with a gold standard—a perfect measure of perceived stress.1 The scale was intervieweradministered so literacy and/or language barriers were minimized.
Consider, for example, for the same as hamlet crazy essay the ability to be the only one time. Use the person's views and present data. Being flexible and realistic research question After thinking through and deciding what style of observation a feasible option.
The data sharing is not meant to completely replace the transcription.


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May 5, 2014
Seek Support as You Prep for the GRE
Remember high school when you were preparing for t... Read more
We know test prep. We invented it. Through innovative technology and a personalized approach to learning, we equip you with the test insights and advice you need to achieve your personal best. Results, guaranteed.*


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Scott Amoroso
Scott Amoroso aka "Scoot" may be one of the most underrated snowboarders in Lake Tahoe. Amoroso is always charging whether he is in the park or out in Huckleberry Canyon. Quiet and humble Amoroso lets his snowboarding speak for itself.
Rider Bio
Name: Scott Amoroso
Hometown: Walnut Creek, CA
Sponsors: Sierra-at-Tahoe, Sentury, MiLo, Yofi
Why do you ride Sierra? Best natural terrain, best parks, best vibes!
Dream date and why? Mobbing thru the bay on an elephant with Keeayshawn. She is a hot little rapper hailing from the East Bay.
Who is your hero? Russell Brainard. My best friend. R.I.P.
Favortie quote? "Life, Love, Lust & Loot" - Captin Morgan


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Elizabeth Wacker and John Dahlheimer, both of Worthington, announce their engagement.
Parents of the couple are Tim and Cheryl Wacker, Perham, and Delbert and Marcy Dahlheimer, Monticello.
Wacker is a 2003 graduate of Perham High School and 2006 graduate of the University of Mary, Bismarck, ND, with a degree in elementary education and theology. She is employed as a second grade teacher at Prairie Elementary School, Worthington.
Dahlheimer is a 2005 graduate of Monticello High School. He is currently pursuing a degree in law enforcement at Minnesota West Community and Technical College, Worthington campus, and is employed by McCuen Construction, Worthington.
The couple will be getting married on Saturday, August 8 in Perham. Friends and classmates are invited to the dance at 8:30 p.m. at the Pioneer Grounds.


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|July 17, 2011
|Posted by Krazy Blogger under Online Money
How Much Do I Earn
Minimum To Cashout
How Much Do I Need To Wait
$0.20 / Answer
7BS Days
Referral Program
Accepted Countries
How To Get Paid
1 Level
What Is Weegy ?
Weegy is a community based expert system. Which has answers to all of your problems. It is some what like talking to a computer which gives you answers to all the questions you ask. You can ask any question you that comes to your mind you could even ask the problems in your math home work or chemistry or any other subject in the world.
When ever some one types a question and ask Weegy. Weegy will search for the answer to the question in its data base. If it finds the answer to the question in its data base than it will instantly answer you. But if does not find the answer in the data base or the user is not satisfied with the answer then you will be sent redirected to a Weegy Expert who is a real person sitting on a computer in any part of the world who can answer your question. If the person does not has the answer to the problem than you will be redirected to another expert until you find the right answer. So who are these Weegy Experts, these are the people just like you sitting on the internet and have enough knowledge to answer to others questions. And for every question they answer as a Weegy Expert the earn $0.20 for each correct answer. To some it might seem really easy. But the users asking questions are real people and you need to have a lot of knowledge and experience to answer questions asked by real people. Some will ask questions regarding their home work, some will ask about novels some will ask about how to lose weight. So be ready to answer some of the weirdest questions you can ever think of. And of course there are those Idiots who will ask your mobile number and sex stuff things like that. In the end if you have enough knowledge and you know a lot about the world then you can easily make money from the site. You will get more answers when the day starts in America I guess more of the users asking questions are from America , Canada and UK in the other parts of the day there are less questions available to answer.
- Paying
They are paying and we have been paid by them.You can see it below
- Nice Earning Opportunity
$0.20 per question answered is a nice income opportunity and worth your efforts and knowledge to be active on the site. The site pays well as compared to may other sites to work on the internet.
- Rewards For Most Active Members
Every Month they reward the experts with the most points Cash prizes are awarded to the top 3 experts: 1st place $30, 2nd place $20, 3rd place $10. How to Earn Points : Points are awarded as follows: 10 points for each positive rating, 5 points for each referred user, 1 point for each comment
- No Forum
Forum is a place where user can interact, share payment proofs, get support from the staff website owner or fellow members and get to know the latest news on the site and they do not have one. Instead they have a blog where they post all the news related to the site. You can check it out here http://www.weegy.com/Home.aspx?Id=BlogPage
- Delay In Payments
A delay in payments has been a problem with the site but they post about it on their blog when ever they are going to be delayed here are a few places on the blog where they posted about it.
And further more they do not have given a specific time to send the payments as they say it
" Payments are transferred to your PayPal account when your account reaches $20. You can view an online summary of your compensation status at any time."
How do I answer questions as Weegy Expert ?
Just Sign Up and then keep click on the Expert Tab and keep that tab open then you will receive questions from time to time to answer questions as a Weegy Expert. You can carry on with some thing else with the Expert Tab open as they will notify you with a beep sound when you need a new question to answer but you have to be quick you only have 15 seconds to accept or decline the question before it is passed on to another Expert.
What If I don't know the answer ?
What If you accepted to answer a question and now do not know the answer to it so just pass the conversation to another Expert. If you write the wrong answer by mistake or on purpose to increase your earnings you will get a warning. In you email and if you get enough warnings your account could get suspended. This the Mail they sent me when I accidently wrote the wrong the answer to the question just by mistake.
"All answers are reviewed by Weegy support moderators. We understand that everyone makes mistakes, but if an expert has an unusually high number of flagged answers, their account will be permanently suspended."
How Do I Increase My Earnings ?
Weegy's fee services allow experts who have established themselves in their area of knowledge to earn a higher level of income from users who are willing to pay a small fee for their premium expertise and advice.For a small fee, Weegy Pro provides an online chat based consultation while Weegy Research provides more in-depth investigation and information collection.Both services allow users to select their expert, so it's important for experts to establish their credibility and rating through the standard Weegy chat service and by posting comments in the Weegy Archive.Experts will always be listed in points order, so higher points leads to more high paying questions. So Just get a good ranking by others and keep on answering questions and you could be selected as an Pro to answer questions. Further more You Earn $0.50 every time a referred user asks a Weegy Pro or Weegy Research question. If you can refer people than you can do great. Note you only Earn for referring users who ask Pro or Research questions not ask questions from Expert they are answered for free.
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Renal Cell Carcinoma Associated With Transcription Factor E3 Expression and Xp11.2 TranslocationIncidence, Characteristics, and Prognosis
We studied the characteristics and prognosis of renal cell carcinoma (RCC) associated with Xp11.2 translocation and transcription factor E3 (TFE3) expression and determined the need for genetic analysis in routine diagnostics. Of 848 consecutive cases, 75 showed microscopic features suggestive of Xp11.2 translocation RCC or occurred in patients 40 years or younger. Of these cases, 17 (23%) showed strong nuclear TFE3 immunostaining, which was associated with more advanced tumors and inverse prognosis in univariate (P = .032) but not multivariate (P = .404) analysis. With fluorescence in situ hybridization and polymerase chain reaction, only 2 cases showed alterations of the X chromosome and the ASPL-TFE3 gene fusion, respectively. In our laboratory, the predictive value of TFE3 expression for the Xp11.2 translocation was 12%. Strong nuclear TFE3 expression is associated with metastatic spread and a poor prognosis. In our laboratory, TFE3 is not diagnostic for Xp11.2 translocation RCC. Diagnosis of Xp11.2 translocation RCC may be made only genetically.
- Transcription factor E3
- Translocation
- Prognosis
- Kidney cancer
In the 2004 World Health Organization (WHO) classification of renal tumors, renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 (TFE3) fusion was delineated as a distinct entity.1 These RCCs are defined by several translocations involving the TFE3 gene that is located on chromosome Xp11.2, resulting in a gene fusion between TFE3 and at least 6 possible partners. The most commonly observed translocations are t(X;17)(p11.2;q25), t(X;1) (p11.2;p34), and t(X;1)(p11.2;q21), which lead to gene fusions of TFE3 with ASPL, PSF, and PRCC, respectively.2,3
Since the translocations lead to overexpression of the TFE3 protein, immunohistochemical staining for TFE3 is widely used as a surrogate marker for the Xp11.2 translocation,4 with strong nuclear TFE3 expression on low-power magnification considered characteristic.5 Epithelial markers such as the cytokeratins are expressed in 50% of the cases,1 but few express proteins of the hypoxia-inducible pathway such as HIF-1α and CAIX.6 Clinical studies have shown that the majority of Xp11.2 translocation RCCs occur in children and young adults.7,8 More than half of the patients have metastatic disease, leading to a poor prognosis.8–11 However, there are only a few larger case series reported in the literature, and, thus, clinicopathologic characteristics and outcomes remain poorly understood.4,9,12 In addition, there have been only a few reports evaluating the accuracy of TFE3 immunostaining by direct comparison of immunohistochemical and genetic analyses.5,13
The aims of this study were as follows: (1) determine the incidence of RCC associated with the Xp11.2 translocation and TFE3 expression in our laboratory, (2) characterize its clinicopathologic features and survival, and (3) evaluate the necessity of genetic analysis in diagnosing Xp11.2 translocation RCC by direct comparison with TFE3 immunohistochemical analysis. For these aims, we analyzed the data for 848 consecutive patients who underwent surgery for RCC at 1 institution during a 20-year period.
Materials and Methods
Study Population and Classification
Following approval by the institutional review board, a retrospective study was undertaken that included histologic reevaluation, immunohistochemical staining, and genetic evaluation. Between 1991 and 2010, a total of 848 patients underwent surgery for a unilateral, sporadic RCC at our institution. All available slides stained with H&E were reevaluated, retyped, and regraded by 1 dedicated uropathologist (A.H.). Further immunohistochemical and genetic studies were performed in tumors that occurred in young patients (≤40 years) and/or showed microscopic features suggestive of Xp11.2 translocation RCC.2,3,14 In this regard, 58 patients (6.8%) were 40 years or younger; of the 790 tumors in patients older than 40 years, 17 (2.2%) displayed microscopic features suggestive of Xp11.2 translocation RCC, defined by papillary structures lined by clear and/or bloated cells. Thus, a total 75 cases were further evaluated, accounting for 8.8% of the total RCC cohort. Sex, symptoms at diagnosis, TNM stage,15 pathologic tumor size, Fuhrman grade, and subtype were recorded for each case.
Immunohistochemical Analysis
Formalin-fixed, paraffin-embedded tissue was used for immunohistochemical analysis with the primary antibody TFE3 (P-16, sc-5958, Santa Cruz Biotechnology, Santa Cruz, CA) using the manual overnight incubation methodology.13 The TFE3 immunohistochemical assay was validated on a genetically confirmed positive control sample. Conditions were titrated so that this control sample gave a positive reaction while other benign tissues and neoplasms did not show immunoreactivity. Furthermore, immunohistochemical staining of the pan-cytokeratins Lu-5 (NeoMarkers MS-744-A, Thermo Fisher Scientific, Fremont, CA) and AE1/AE3 (DAKO M3515, DAKO, Carpinteria, CA) was performed.5 Antigen retrieval was performed using microwave or protease pretreatment. Primary antibody binding was determined using a biotinylated secondary antibody (Vector BA-5000 or BA-2000, Vector Laboratories, Burlingame, CA) and avidinbiotin complex (VECTASTAIN Elite ABC Kit, Vector) with 3′-diaminobenzidine as the chromogen.16 Immunohistochemical staining was evaluated by 2 pathologists (F.W. and A.H.). After individual assessment, a consensus was reached. Only strong nuclear TFE3 immunoreactivity was considered TFE3+ Image 1A, Image 1B, and Image 1C, while a cytoplasmic reaction was considered negative. Confirmatory immunohistochemical analysis for TFE3 was performed as recommended.5 There was no stromal reaction that could reflect high background. Within tubular cells, very weak cytoplasmic labeling was found occasionally (Image 1C).
Fluorescence In Situ Hybridization
A dual-color, break-apart fluorescence in situ hybridization (FISH) assay was performed according to Zhong et al,17 using the BAC clones RP11-107C19 and RP11-528A24. In brief, FISH of interphase nuclei was performed on 4-μm-thick, paraffin-embedded sections. RP11-107C19 and RP11-528A24 were labeled with 5-TAMRA deoxyuridine triphosphate (dUTP) and 5(6)-rhodamine green dUTP, respectively. After sample preparation, hybridization with labeled DNA was performed overnight. Slides were counterstained with 4,6-diamidino-2-phenylindole (DAPI, Vysis, Abbott Park, IL) and analyzed with a fluorescence microscope (Zeiss, Oberkochen, Germany) Image 1D. FISH was regarded as positive when more than 10% of the tumor nuclei had evidence of Xp11 rearrangement.
Polymerase Chain Reaction
Polymerase chain reaction (PCR) was performed to detect the ASPL-TFE3 gene fusion transcript according to established methods.12,18 RNA was extracted from paraffin-embedded tumor material from all patients using the High Pure RNA Paraffin kit (product No. 3270289, Roche Diagnostics, Indianapolis, IN). Following reverse transcription (Superscript IIFirst strand No. 11904-018, Invitrogen, Vienna, Austria), PCR amplification was performed with a specific primer pair for the translocation ASPL-TFE3 t(X;17), as described previously.12,18 PCR products were separated on an agarose gel and visualized by ethidium bromide staining. The amplified fragments were identified by their size and then subjected to automatic sequencing using a BigDye Terminator Cycling Sequencing kit on a DNA analyzer (Applied Biosystems, Carlsbad, CA).
Statistical Analysis
Categorical data were compared by using the Fisher exact test, and the Student t test was used to compare continuous data. Disease-specific survival (DSS) was calculated from the date of surgery to death of RCC or last follow-up. DSS functions were estimated with the Kaplan-Meier method and compared with log-rank tests. Multivariate Cox proportional hazards models were fit to determine independent predictors of DSS. The statistical package R 2.10.1 (http://cran.r-project.org) was used for all analyses.
Patient and tumor characteristics are summarized in Table 1. Of the 848 RCCs that were reevaluated, 75 were further analyzed by immunohistochemical analysis and FISH. In this cohort, none of the patients had a history of malignant tumors. Metastatic spread to regional nodes or distant sites was detected in 12 cases (16%). None of the tumors occurred in a multifocal manner.
Immunohistochemical Findings
Of the 75 tumors, 17 (23%) showed strong, diffuse nuclear TFE3 expression in the entire tumor (TFE3+). In stromal or tubular cells, no nuclear staining was found. Occasionally, weak cytoplasmic staining was observed in some tubular structures but not in stromal cells. In addition, the staining intensity was much stronger in the nuclei of the tumor compared with the cytoplasm of the tubular cells (Image 1C).
In patients 40 years or younger, a total of 13 (22%) of 58 tumors were TFE3+. According to age at the time of surgery, the incidence values of TFE3 positivity in the age ranges 0 to 10, 11 to 20, 21 to 30, and 31 to 40 years were 67% (2/3), 75% (3/4), 29% (2/7), and 14% (6/44), respectively (P < .001) Figure 1. (TFE3 negativity was as follows for the age groups: 0–10 years, 1/3 [33%]; 11–20 years, 1/4 [25%]; 21–30 years, 5/7 [71%]; and 31–40 years, 38/44 [86%]).
Clinical and pathologic features were compared between TFE3+ and TFE3– cases and all microscopically negative RCC cases. Patients with TFE3+ RCC more frequently had symptoms, larger tumors, and metastases (Table 1). Of the 6 patients with TFE3+ RCC with distant metastasis, 5 (83%) had concomitant regional lymph node involvement, compared with only 14 (14%) of 98 in the negative cases (P < .001). Tumors with an extensive papillary growth pattern were more frequently seen in TFE3+ RCC (35% [6/17] vs 21% [12/58] and 35% [6/17] vs 17.7% [137/773], respectively), although the differences were not statistically significant (P = .357 and P = .219, respectively). In tumors with positive and negative TFE3, the percentage of tumors staining positively for Lu5 and AE1/3 was similar (Lu5 positive, 71% [12/17] vs 66% [38/58]; P = .922; AE1/3, 65% [11/17] vs 53% [31/58]; P = .586).
The mean follow-up was 44 months (SD, 41.8 months; range, 1–120 months), during which 85 patients died of the disease, including 6 (35%) of 17 with TFE3+ RCC. The mean ± SE 5-year DSS rates for TFE3+ RCC, TFE3– RCC, and the remaining histologically negative RCC cases were 62% ± 12%, 90% ± 4%, and 82% ± 2%, respectively. The survival difference between TFE3+ and TFE3– cases was statistically significant (P = .032) Figure 2, as was the difference between the TFE3+ and remaining histologically negative RCCs (P = .024; Figure 2). For multivariate analysis, TFE3– cases and histologically negative cases were pooled because they did not differ in terms of pathologic factors (each P > .2) and survival (P = .313). In the multivariate model, T stage, N stage, M stage, and grade, but not TFE3 immunostaining, were retained as independent prognostic factors of DSS Table 2.
Genetic Analysis
All 75 tumors were evaluated by FISH and PCR. Here, 2 tumors (3%) showed an X-chromosome alteration in the FISH and the ASPL-TFE3 fusion transcript in the sequence. Therefore, these 2 tumors represented Xp11.2 translocation RCC with ASPL-TFE3 gene fusion. In the remaining 73 tumors, neither FISH nor PCR was positive. Both translocation RCCs also showed strong nuclear TFE3 expression. Thus, the sensitivity of TFE3 immunostaining for Xp11.2 translocation RCC was 100% (2/2), with a specificity of 79% (58/73) and a negative predictive value of 100% (58/58). However, the positive predictive value of positive TFE3 staining for Xp11.2 translocation RCC was only 12% (2/17). There were only 2 (0.2%) of 848 RCCs with genetically proven Xp11.2 translocation during a 20-year period.
The first patient was a 5-year-old boy who had a 12-cm renal tumor. A Wilms tumor was suspected, and the patient underwent preoperative chemotherapy without any response, followed by open radical nephrectomy with regional lymph node dissection. TNM stage was pT3a pN1 (2/10) pM1 (liver). Postoperatively, the patient received vaccination with tumor-lysate pulsed dendritic cells in combination with interferon-alfa-2a. The interferon-alfa-2a therapy was maintained for 4.5 years. The patient achieved a complete response and, at last follow-up, was alive without evidence of disease. The second patient was a 42-year-old woman who had an 8-cm renal mass found during the workup for flank pain. Open radical nephrectomy was performed, revealing Fuhrman grade 2 RCC with TNM stage T2N0M0. At 8 years after surgery, she was alive without evidence of disease.
We reevaluated the data for 848 patients who underwent surgery for RCC. We found that the incidence of Xp11.2 translocation RCC is very low, that TFE3 is an immunohistochemical marker of metastasis and poor survival, and that, although TFE3 expression is associated with Xp11.2 translocation, only a minority of these tumors shows the Xp11.2 translocation in our laboratory. Therefore, TFE3 should not be used as a surrogate marker for the translocation. In our laboratory, definite diagnosis of Xp11.2 translocation RCC may be made only by genetic analysis.
The overall incidence of Xp11.2 translocation RCC is very low, with an increased risk in children and young adults.7,9,11 Within a 20-year period, we observed only 2 cases of this disease (0.2%). These data are in accordance with a multicenter study on 3,423 kidney tumors, in which only 31 translocation RCCs (0.9%) were found.9 In another large screening study of 443 adults with RCC, only 7 translocation RCCs (1.6%) were observed.4 Bruder et al19 specifically analyzed the data for pediatric and adolescent populations. In their study, 8 (20%) of 41 tumors were identified as translocation RCC. Reinforcing the concept of low incidence, these 8 tumors were diagnosed at 2 centers during a 25-year period. In pediatric patients, the incidence may be higher after chemotherapy.20
The diagnosis of an Xp11.2 translocation RCC is based on microscopic appearance, TFE3 immunostaining, and genetic analyses. In our hands, TFE3 was a highly sensitive and specific immunohistochemical marker for screening tumors for the Xp11.2 translocation. These data are in line with a previous report on more than 1,500 cases; however, in this large study, no TFE3+ cases without the Xp11.2 translocation were observed.5 In contrast, we and others19,21 identified cases that strongly expressed TFE3 but did not have the Xp11.2 translocation. In total, the incidence of an Xp11.2 translocation among our TFE3+ cases was fairly low, with a positive predictive value of only 12%. Hence, in our laboratory, the diagnostic value of TFE3 was lower than reported previously.5 Methodological differences may partially explain this fact, including differences in the lot of the polyclonal antibody and differences in detection methods. We further suspect that the enhanced detection method used in our study may result in the detection of native TFE3 more frequently. In this regard, Argani et al13 recently noted that the incubation method (automated vs overnight) alters the diagnostic value of TFE3 staining with an increased detection of native TFE3.
Our results are further supported by a recent multicenter study of 252 patients with RCC who were younger than 35 years or older than 80 years.21 The tumors were all reclassified according to the World Health Organization classification, TFE3 was evaluated by immunohistochemical analysis, and comparative genomic hybridization was performed for genetic analysis. On reclassification, only 3 tumors (1.2%) showed histologic features suggestive of translocation RCC. TFE3 stained positively in 12% of tumors from younger patients (<35 years) and 0.5% of older patients (>80 years). It is important to note that no specific genetic alterations could be detected.21 We conclude that, in our laboratory, strong nuclear TFE3 expression may not be caused by translocations only, but also by other biologic pathways that yet have to be identified. TFE3 should not be used as a surrogate marker for the translocation. Definite diagnosis of Xp11.2 translocation RCC may be made only by genetic analysis. Given the conflicting data in the literature, however, further studies are necessary.
Traditionally, Xp11.2 translocation RCC has been associated with advanced tumor stage and a poor prognosis.2,8,11,12 Studies indicate that about half of the patients have metastatic disease8,11,12,22 and that the majority of patients will finally die of progressive RCC.11,12,22 However, our data and the data of others show that some patients have considerable long-term survival, even in the setting of metastatic disease.2,4,23 Furthermore, it was shown in a literature review that ASPL-TFE3 gene fusion RCC is more likely to present at an advanced stage than is PRCC-TFE3 RCC.24 Our 2 genetically confirmed cases of ASPL-TFE3 gene fusion had a favorable outcome in short-term follow-up, while strong TFE3 staining was generally associated with poor survival. This fact may further indicate that in a proportion of tumors with strong TFE3 staining, native TFE3 was detected.
Recently, Malouf et al22 evaluated 53 cases of translocation RCC, of which 23 were metastatic. In the latter group, 21 patients received targeted therapy with vascular endothelial growth factor receptor–targeted agents and/or mTOR inhibitors. Of note, 7 patients (33%) achieved an objective response and median overall survival was 27 months, which is comparable to the general population receiving these agents.25,26 The response to mTOR inhibitors may be partially explained by elevated expression levels of phosphorylated S6.6 Given the relatively low incidence of this entity and the relatively few cases reported in the literature, one may only conclude that the majority of Xp11.2 translocation RCCs occur with metastatic disease; however, it may be too early to conclude clinical outcomes.
There is now considerable evidence that immunohistochemical and genetic markers may assist in determining the prognosis in RCC and, therefore, in tailoring postoperative surveillance and therapy.27–29 In this regard, the value of TFE3 as a routine immunohistochemical marker may be 3-fold: as a prognostic factor, as an indicator of concomitant lymph node involvement, and as a screening marker for Xp11.2 translocation before genetic analysis, as described. We and others12 found a strong association of TFE3 expression with regional lymph node metastasis, which is generally accepted as a poor prognostic marker in the setting of metastatic RCC.30 Thus, TFE3 may assist in assigning risk groups in these cases, which subsequently guides systemic therapy. In addition, TFE3 may indicate the need for regional node dissection in patients with clinically localized disease, which may be of benefit in selected cases.31–33 TFE3 may further predict prognosis, although this marker was not retained as an independent prognostic factor in multivariate analysis, which may be due to the relatively low number of patients with TFE3+ RCC and the subsequent low statistical power. Further studies with larger numbers of cases are necessary to elucidate this role.
There are several issues in the present study that merit discussion. We did not evaluate TFE3 expression in patients older than 40 years with RCC histologically negative for Xp11.2 translocation. Thus, we may have missed some cases, although the overall incidence in this group is low.4 Since our data indicate that TFE3 can be positive in RCCs without the translocation, the incidence of TFE3+ tumors and the prognostic relevance of this marker may be underestimated. We did not evaluate fusions that are much less common than ASPL-TFE3, such as PSF-TFE3 and PRCC-TFE3. However, it is unlikely that PCR would have been positive in the absence of positive FISH results.17 Finally, the retrospective nature and the relatively low number of cases limit the strength of the conclusions, so that all data should be confirmed with larger data sets.
The incidence of Xp11.2 translocation RCC is very low. Strong nuclear TFE3 expression is associated with metastatic spread and a poor prognosis; however, it is not diagnostic for Xp11.2 translocation RCC and should, therefore, not be used as a surrogate marker in our laboratory. In our laboratory, definite diagnosis of Xp11.2 translocation RCC may be made only by genetic analysis.
- © American Society for Clinical Pathology


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The Model Lounge (created & produced by UA Marketing + Management) is an exclusive retreat for female models at invited Top 10 Modeling Agencies in NYC. The Model Lounge provides female models special privileges via the ultra-exclusive "All Access Privilege Card" and a destination where they can hang in between castings + shoots on a daily basis while being pampered and entertained. The Model Lounge operates in NYC at Soho based Delicatessen - in the downstairs private lounges. For brands, the Model Lounge provides a unique and unparalleled marketing opportunity targeting the most sought after female influencers/early adopters.
For more information, please visit www.modellounge.blogspot.com or contact Bernard Smith | firstname.lastname@example.com | Tel. 646-707-0454
# # #


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Christian McBride & Inside Straight: Kind of Brown
The elegant funk of the opening blues, "Brother Mister," allows Reed, Wilson and Wolf to warm up on a down-home groove set up by McBride and Allen. The breezy mood is then interrupted as McBride rips through the intro to Freddie Hubbard's up-tempo swinger, "Theme for Kareem." The ferocious post-bop vibe showcases the quintet's command of the modern jazz language with unrivaled technique.
Lyricism shines through on "Rainbow Wheel" and "Starbeam," two of McBride's more poignant compositions. The gospel vibe of "Used 'Ta Cha" is a spirited good time with fun, blues-based soloing from all, including a punchy bowed turn from McBride. "The Shade of the Cedar Tree," which first appeared on McBride's debut as a leader, Gettin' To It (Verve, 1995), moves elegantly from swing to Latin with soaring solos from Wolf, Wilson and Reed.
Reed's vivacious "Pursuit of Peace" has a straight-forward melody on top of an intricate bass line, creating a contrapuntal effect with plenty of soul. McBride's beautiful waltz tribute to the late pianist James Williams, "Uncle James," features an impressive melodic turn from Wilson on soprano saxophone. "Stick & Move" is a barn-burner of a blues ripe with juicy blowing. The go-for-broke attitude here is a highlight of the session.
McBride closes the disc with bow in hand on the standard "Where Are You?," done as a lovely duet with reed; a quiet close to a disc of utmost sophistication and virtuosity.
Track Listing: Brother Mister; Theme for Kareem; Rainbow Wheel; Starbeam; Used 'Ta Could; The Shade of the Cedar Tree; Pursuit of Peace; Uncle James; Stick & Move; Where Are You?.
Personnel: Christian McBride: bass; Carl Allen: drums; Eric Scott Reed: piano; Steve Wilson: alto saxophone, soprano saxophone; Warren Wolf, Jr.: vibes.
Related Video
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Clerow's FlippedChristian McBride
Live at Tonic
Live Reviews
Jazz Art
Multiple Reviews
CD/LP/Track Review
- People Music by J Hunter
Multiple Reviews
CD/LP/Track Review
- Conversations With Christian by Dan Bilawsky


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What are the most valuable sports team in the world?
We now have some answers, thanks to Forbes, which compiled a list of the world's 50 most valuable sports teams.
Which team is on top of the list? That would be soccer power Real Madrid, with an estimated value of $3.3 billion.
Another soccer power -- Manchester United -- ranks second at 3.165 billion. Fellow soccer giant FC Barcelona is third (2.6 billion) followed by Major League Baseball's New York Yankees (2.3 billion) and the NFL's Dallas Cowboys ($2.1 billion).
Find out more by reading the Forbes report HERE and checking out he compiled coverage below.
What are your thoughts CLICK HERE to leave us a "QUESTION OF THE DAY" comment.
© Copyright 2016, A Quincy Media broadcasting station. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Submissions from 2016
Dead Trees Don't Mean Catastrophe for California, Char Miller
Embers, Char Miller
Fire Inevitable, Despite Attempts to Tame Chaparral, Char Miller
Malheur Occupation in Oregon: Whose Land is it Really?, Char Miller
One View: Fire Fuels Regeneration in Eastern Sierra, Char Miller
Rethinking LA's Nature through German Eyes, Char Miller
The Erskine Fire and Public-Lands Management in the American West, Char Miller
The Pinchot Wire: Private Cash, Public Lands - Why the Katahdin Woods and Waters National Monument Matters, Char Miller
The Studio #dhcc16: Space in Time; or, What We See Depends on When We See It, Char Miller
Umdenken: von der Natur lernen (Rethinking: Learning from Nature): Some personal thoughts on the Goethe Institute traveling exhibition, Hans J. Rindisbacher
Rethinking: Wind, Wende, Wandel, Friederike von Schwerin-High
Submissions from 2015
Little Bridges, Lebus Court, and Rembrandt Hall: A Centennial Celebration, George Gorse
Glossaries of Philosophical Terms, Richard D. McKirahan
Submissions from 2014
A Better Way to Restore Wildfire-Burned Forests, Char Miller
Negating Negationism, Kenneth Baxter Wolf
Submissions from 2013
School Choice as a One-Sided Matching Problem: Cardinal Utilities and Optimization, Sinan Aksoy, Alexander Adam Azzam, Chaya Coppersmith, Julie Glass, Gizem Karaali, Xueying Zhao, and Xinjing Zhu
Supercharacters, Exponential Sums, and the Uncertainty Principle, J.L. Brumbaugh '13, Madeleine Bulkow '14, Patrick S. Fleming, Luis Alberto Garcia '14, Stephan Ramon Garcia, Gizem Karaali, Matt Michal '15, and Andrew P. Turner '14
The Graphic Nature of the Symmetric Group, J.L. Brumbaugh '13, Madeleine Bulkow '14, Luis Alberto Garcia '14, Stephan Ramon Garcia, Matt Michal '15, and Andrew P. Turner '14
On the Matrix Equation XA + AX_T = 0, II, Alice Zhuo-Yu Chan '14, Luis Alberto Garcia '14, Stephan Ramon Garcia, and Amy L. Shoemaker '14
The Graphic Nature of Gaussian Periods, William Duke, Stephan Ramon Garcia, and Bob Lutz '13
Intrinsic Chirality of Multipartite Graphs, Erica Flapan and Will Fletcher
Topological Symmetry Groups of Graphs in 3-Manifolds, Erica Flapan and Harry Tamvakis
Quotients of Gaussian Primes, Stephan Ramon Garcia
Review: Cyclicity Results for Some Antianalytic Toeplitz Operators Acting on H^p, Stephan Ramon Garcia
Review: On Some Bergman Shift Operators, Stephan Ramon Garcia
Which Weighted Composition Operators are Complex Symmetric?, Stephan Ramon Garcia and Christopher Hammond
On the Norm Closure Problem for Complex Symmetric Operators, Stephan Ramon Garcia and Daniel E. Poore '11
Recent Progress on Truncated Toeplitz Operators, Stephan Ramon Garcia and William T. Ross
C*-algebras Generated by Truncated Toeplitz Operators, Stephan Ramon Garcia, William T. Ross, and Warren R. Wogen
A Method for Generating Realistic Correlation Matrices, Johanna S. Hardin, Stephan Ramon Garcia, and David Golan
Math: That Thing You Do, Mark L. Huber and Gizem Karaali
Book Review: The 5 Elements of Effective Thinking, Gizem Karaali
Selma Karaali and Artemis Karaali, Gizem Karaali
The Brave New World of Open Access & Creative Commons: a Humanistic Experiment in Mathematical Publishing, Gizem Karaali
The Colors of Math, Gizem Karaali
Collections Containing Articles on Presocratic Philosophy, Richard D. McKirahan
Making Common Cause for Conservation: The Pinchot Institute and Grey Towers National Historic Site, 1963-2013, Char Miller
Riding the Wave: Open Access, Digital Publishing, and the Undergraduate Thesis, Char Miller
Uncle Sam's Badge: Identity and Representation in the USDA Forest Service, 1905–2013, Char Miller
Submissions from 2012
Supercharacters, Symmetric Functions in Noncommuting Variables, and Related Hopf Algebras, Marcelo Aguiar, Carlos André, Carolina Benedetti, Nantel Bergeron, Zhi Chen, Persi Diaconis, Anders Hendrickson, Samuel Hsiao, I. Martin Isaacs, Andrea Jedwab, Kenneth Johnson, Gizem Karaali, Aaron Lauve, Tung Le, Stephen Lewis, Huilan Li, Kay Magaard, Eric Marberg, Jean-Christophe Novelli, Amy Pang, Franco Saliola, Lenny Tevlin, Jean-Yves Thibon, Nathaniel Thiem, Vidya Venkateswaran, C. Ryan Vinroot, Ning Yan, and Mike Zabrocki
What Does It Take to Teach Nonmajors Effectively?, Feryal Alayont, Gizem Karaali, and Lerna Pehlivan
Medicine, Statistics, and Education: The Inextricable Link, Katharine K. Brieger '11 and Johanna S. Hardin
Best Practices in Mathematical Modeling, Lisette G. de Pillis and Ami E. Radunskaya
Unravelling Tangled Graphs, Catherine Farkas, Erica Flapan, and Wynn Sullivan '10
Giving It Away: Sharing and the Future of Scholarly Communication, Kathleen Fitzpatrick
Spatial Graphs with Local Knots, Erica Flapan, Blake Mellor, and Ramin Naimi
Ramanujan Sums as Supercharacters, Christopher F. Fowler '12, Stephan Ramon Garcia, and Gizem Karaali
Burgess Shale-Type Biotas Were not Entirely Burrowed Away, Robert Gaines, M. L. Droser, P. J. Orr, D. Garson, E. U. Hammarlund, C. Qi, and Donald Canfield
Dynamic Palaeoredox and Exceptional Preservation in the Cambrian Spence Shale of Utah, Robert Gaines, Daniel E. Garson, Mary L. Droser, W. David Liddell, and Aaron Sappenfield
Mechanism for Burgess Shale-Type Preservation, Robert Gaines, E. U. Hammarlund, Xianguang Hou, C. Qi, Sarah E. Gabbott, Y. L. Zhao, J. Peng, and Donald Canfield
Formation of the 'Great Unconformity' as a Trigger for the Cambrian Explosion, Robert Gaines and Shanan E. Peters
Review: Embeddings of Model Subspaces of the Hardy Class: Compactness and Schatten–von Neumann Ideals, Stephan Ramon Garcia
Review: The Dirichlet Space: A Survey, Stephan Ramon Garcia
Three Questions about Complex Symmetric Operators, Stephan Ramon Garcia
Two Remarks about Nilpotent Operators of Order Two, Stephan Ramon Garcia, Bob Lutz '13, and D. Timotin
On the Closure of the Complex Symmetric Operators: Compact Operators and Weighted Shifts, Stephan Ramon Garcia and Daniel E. Poore '11
Unitary Equivalence to a Truncated Toeplitz Operator: Analytic Symbols, Stephan Ramon Garcia, Daniel E. Poore '11, and William T. Ross
Unitary Equivalence to a Complex Symmetric Matrix: Low Dimensions, Stephan Ramon Garcia, Daniel E. Poore '11, and James E. Tener '08
On the Matrix Equation XA + AX_T = 0, Stephan Ramon Garcia and Amy L. Shoemaker '14
Unitary Equivalence of a Matrix to Its Transpose, Stephan Ramon Garcia and James E. Tener '08
Changes Across 25 Years of Statistics in Medicine, Johanna S. Hardin
Kinetics of Bile Salt Binding to Liposomes Revealed by Carboxyfluorescein Release and Mathematical Modeling, Peter Hinow, Ami E. Radunskaya, Ian Tucker, and Lin Yang
Games Mathematicians Play, Mark L. Huber and Gizem Karaali
Mathematical Creation, Mark L. Huber and Gizem Karaali
Book Review: Topics in Physical Mathematics, Gizem Karaali
Humanistic Mathematics: An Oxymoron?, Gizem Karaali
In Defense of Frivolous Questions, Gizem Karaali
On the Quantization of Zero-Weight Super Dynamical R-Matrices, Gizem Karaali
Review: An Operator Approach to the Rational Solutions of the Classical Yang-Baxter Equation, Gizem Karaali
Review: Classification of Four and Six Dimensional Drinfel'd Superdoubles, Gizem Karaali
Review: Lusztig Symmetries and Automorphisms of Quantum Superalgebras, Gizem Karaali
A Multiple Time-scale Computational Model of a Tumor and Its Micro Environment, Ami E. Radunskaya, Christopher DuBois, Jesse Farnham, and Eric Aaron
Submissions from 2011
Coalitions and Cliques in the School Choice Problem, Sinan Aksoy, Alexander Adam Azzam, Chaya Coppersmith, Julie Glass, Gizem Karaali, Xueying Zhao, and Xinjing Zhu
Topological Symmetry Groups of K4r+3, Dwayne Chambers '12, Erica Flapan, and John D. O'Brien
A Topological Approach to Molecular Chirality, Erica Flapan
A Topological Approach to Molecular Chirality, Erica Flapan
How to Be a Good Teacher is an Undecidable Problem, Erica Flapan
Complete Graphs whose Topological Symmetry Groups are Polyhedral, Erica Flapan, Blake Mellor, and Ramin Naimi
Classical Kloosterman Sums: Representation Theory, Magic Squares, and Ramanujan Multigraphs, Patrick S. Fleming, Stephan Ramon Garcia, and Gizem Karaali
New Burgess Shale-Type Locality in the "Thin" Stephen Formation, Kootenay National Park, British Columbia: Stratigraphic and Paleoenvironmental Setting, Robert Gaines
Stratigraphic and Microfacies Analysis of the Kaili Formation, a Candidate GSSP for the Cambrian Series 2-Series 3 Boundary, Robert Gaines, John A. Mering '10, Yuanlong Zhao, and Jin Peng
Do Longer Delays Matter? The Effect of Prolonging Delay in CTL Activation, Angela Gallegos and Ami E. Radunskaya
Review: Nearly Invariant Subspaces for Backwards Shifts on Vector-Valued Hardy Spaces, Stephan Ramon Garcia
Review: On the Near Periodicity of Eigenvalues of Toeplitz Matrices, Stephan Ramon Garcia
Unitary Equivalence to a Complex Symmetric Matrix: A Modulus Criterion, Stephan Ramon Garcia, Daniel E. Poore '11, and Madeline K. Wyse '11
Unitary Equivalence to a Complex Symmetric Matrix: A Modulus Criterion, Stephan Ramon Garcia, Daniel E. Poore '11, and Madeline K. Wyse '11
Spatial Isomorphisms of Algebras of Truncated Toeplitz Operators, Stephan Ramon Garcia, William T. Ross, and Warren R. Wogen
Quotient Sets and Diophantine Equations, Stephan Ramon Garcia, Vincent Selhorst-Jones '09, Daniel E. Poore '11, and Noah Simon '08
Geologic Map of the Ganiki Planitia Quadrangle (V–14), Venus, Eric B. Grosfils, Sylvan M. Long, Elizabeth M. Venechuk, Debra M. Hurwitz, Joseph W. Richards, Brian Kastl, Dorothy E. Drury, and Johanna S. Hardin
Multigraded Combinatorial Hopf Algebras and Refinements of Odd and Even Subalgebras, Samuel Hsiao and Gizem Karaali
Vampire Statistics and Other Mathematical Oddities, Mark L. Huber and Gizem Karaali
Welcome to the Journal of Humanistic Mathematics, Mark L. Huber and Gizem Karaali
An Evaluative Calculus Project: Applying Bloom's Taxonomy to the Calculus Classroom, Gizem Karaali
Book Review: Algebra, Gizem Karaali
Book Review: The Complete Idiot's Guide to Algebra Word Problems, Gizem Karaali
Book Review: Thinking Mathematically, Gizem Karaali
Have You Seen This? Journal of Humanistic Mathematics, Gizem Karaali
Media Highlights: Journal of Humanistic Mathematics, Gizem Karaali
Review: Massey Products on Cycles of Projective Lines and Trigonometric Solutions of the Yang-Baxter Equations, Gizem Karaali
Inter-Colony Comparison of Diving Behavior of an Arctic Top Predator: Implications for Warming in the Greenland Sea, Nina J. Karnovsky, Zachary W. Brown '07, Jorg Welcker, Ann M.A. Harding, Wojciech Walkusz, André Cavalcanti, Johanna S. Hardin, Alexander Kitaysky, Geir Gabrielsen, and David Grémillet


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Hi all,
I had be experience lower right back pain and feeling numb etc. Tingling and pins and needles in my right leg.
I got the results today and was told I have minor lumbar scoliosis concave to the right.
The doctor did explain it about my spine being tilted to the right and that I need to lose weight.
Can someone explain scoliosis?
Know the five types of psoriasis and how to spot flares.
Newer diabetes treatments can suppress appetite and aid weight loss.
Try these tips to get your salivary glands back into action.
Constipation is a common side effect of opioid and narcotic pain medicines.
Is it sensitive skin or something else?


text:
Manhattan Ensemble Theater Photos on BroadwayWorld.com
Manhattan Ensemble Theater News Feeds
Latest News on Manhattan Ensemble Theater
Manhattan Ensemble Theater Photos on BroadwayWorld.com
Latest News on Manhattan Ensemble Theater
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Enter your email address above to be notified when new photos are available.
- Stew & Heidi Rodewald to Appear on Stage at The Public in Their New Musical THE TOTAL BENT (Apr 11, 2016)
- Branden Jacobs-Jenkins' AN OCTOROON to Play the Wilma Theater (Feb 24, 2016)
- The Drama League's Longtime Artistic Director Roger T. Danforth Resigns (Feb 9, 2016)
- Roger T. Danforth Resigns as Artistic Director of The Drama League (Feb 9, 2016)
- Lineup Announced for 'Festival of the Emerging Musical' in Philadelphia (Jan 25, 2016)
- VIDEO: Sneak Peek - Jim Parsons Has Emotional Reading on Next LONG ISLAND MEDIUM (Dec 29, 2015)
- Joe's Pub at The Public to Welcome Jamie Leonhart & Joanna Settle, 11/1-3 (Oct 7, 2015)
- VIDEO: First Look - Jim Parsons Stars in New Horror Film VISIONS (Aug 11, 2015)
- All His Heavenly Hosts! Meet the Full Cast of AN ACT OF GOD, Opening Tonight on Broadway (May 28, 2015)
- VIDEO: AN ACT OF GOD's Jim Parsons Receives Star on Hollywood Walk of Fame (Mar 12, 2015)


text:
Finishing up an interactive infographic illustration for the Atlantic for a computer company (name with held till launch). See the full size image here http://studiobrill.com/images/dribbble/tasi.jpg
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Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
Copyright © 2009–2016 Dribbble LLC. All screenshots © their respective owners. Shipped from Salem, Mass. USA.


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On Demand
Yelling To The Sky
- Summary
- Reviews / Ratings
- Photos
- Videos
- Events
Available same day as theatrical release. Beautiful and smart, 17-year-old Sweetness O'Hara sees her deeply troubled family fall apart, and is left to fend for herself in a neighborhood intolerant of her mixed race background.
More Details
Released - Friday, December 14 , 2012


text:
Darton State College Nursing Department | Associate Degree Program | Swainsboro Track
Home » Programs » Nursing » Associates Program
Swainsboro Track
Darton State College will no longer offer this site.
The final cohort of students will complete in May 2017.
Students will be required to meet all the admission requirements of Darton State College. Classes are held at East Georgia State College. The location of clinicals will be held at locations in Swainsboro and the surrounding area. All five semesters can be done at East Georgia State College.
For more information, please contact the Nursing Department office at East Georgia State College or Darton State College.
East Georgia State College Building C
Offices C125 & C127
Bridget L. Clarke
Admin Assistant
All students in the Darton State College nursing program must have health insurance. Students who do not have health insurance must purchase a USG student health insurance policy (SHIP). Fees for the USG SHIP will be added to student tuition each semester. Students who are already covered by an insurance policy (i.e., through parent plans, family plans, or employer-sponsored plans) can easily opt out of the plan by applying for a waiver though a secure online process. Once the information has been verified and approved, a waiver will be processed and posted to the student's Darton State College student account. Waivers are valid for 12 months; students must reapply each year to avoid being charged for the USG SHIP. Students who fail to submit credible health insurance and opt out online will automatically be enrolled in and billed for the system-wide student health insurance plan. This charge will post to the Darton State College student account. Professional liability insurance is also required and is included in student fees.
The Nursing department is responsible for the information on this page.
For questions regarding content, or for further information, please contact Email: Bonnie Hardegree or Email: Sherry Koster
Department Chair: Larecia Gilll, MSN, RN.
Last Update: July 11, 2016 9:15 AM
The Darton State College web site is maintained by the Technology Services Division.


text:
This deal has ended.
Bloomingdales takes 30% off a great selection of Lesportsac bags as part of their latest sale. Better yet, code HARPERS stacks to take an extra 10% off. The Kasey Crossbody Bag in Moonflower (pictured) drops from $38 to $26.60 to $23.94, the Deluxe Everyday Bag drops from $78 to $58.50 to $52.65, and the Airport Friendly Laptop Bag drops from $108 to $75.60 to $68.04. Shipping is from $6 or free over $300 (Bloomingdale's card holders get free shipping with $150). Sales tax is charged in states with Bloomingdale's retail locations.No longer available


text:
The Other Sister (1999)
Plot Summary
When Carla Tate, now a young woman, is 'graduated' out of the training school where she has resided for many years because she is mentally challenged, her hope is that she will be accepted for all that she can now do for herself. But Carla's family is wealthy which permits her mother, already blinded to her daughter's rather high-functioning abilities, to try and provide for Carla beyond her needs or desires, bringing forth the inevitable confrontations... for what Carla may lack in mental ability she certainly makes up for in her insistence on being independent, even to living in her own apartment. But if this isn't enough, into the mix comes a young man, equally challenged mentally, who moves Carla beyond anyone's control...- Written by BOB STEBBINS <firstname.lastname@example.com>
A mentally challenged girl proves herself to be every bit as capable as her "perfect" sister when she moves into an apartment and begins going to college.- Written by JoJo Mac
A chauffeured car drops Dr. Radley Tate ( ) off at the Roselake school to pick up his daughter...See full synopsis » (Warning: contains spoilers!)


text:
realmagick.com The shrine of knowledge.
Brahmanda Purana
A selection of articles related to brahmanda purana.
Original articles from our library related to the Brahmanda Purana. See Table of Contents for further available material (downloadable resources) on Brahmanda Purana.
- The Horned God in India and Europe
- Of all of the Gods that we honor in Paganism today probably the most revered is the Horned God, in the shape and form of Cernunnos. Pick up some modern Pagan literature and chances are he is in there, listen to conversation at a Moot and you will hear him...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
Brahmanda Purana is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Brahmanda Purana books and related discussion.
Suggested News Resources
- Bermuda Triangle Mystery Revealed in Rig Veda & Atharva Veda Long Back
- According to Brahmanda Purana (composed more than 5000 years ago) and Rig Veda (written more than 23000 years ago) planet Mars was born out of Earth .Hence Mars is referred as Bhauma ('son of Bhumi') or Kuja (Ku = Earth + Ja = Born out of ) in ...
- Desire is not bad, but there must be a balance between power and governance
- In the Puranas, he is the champion of Indra, who is unleashed to distract ascetics. In Buddhism, however, Kama was visualised as a ... Brahmanda, the Sanskrit word for cosmos, essentially refers to a bubble.
- More beautiful than Vaikunta
- According to Brahmanda Purana this is the place where Guru Sukraacharya did penance and got back his lost vision with the grace of Lord Vishnu. Hence the place was named as Velliankudi where 'Velli' means 'Sukra.' It is believed that anyone who visits ...
- Hindu Mythology Accepts Homosexuality, Why Can't You?
- In Shiva Purana, the birth of Hanuman is attributed to the union between Shiva and Mohini. In the Brahmanda Purana, Shiva's wife Parvati "hangs her head in shame" when she sees her husband's pursuit of Mohini. In the Ramayana, two widows who want to ...
- Lord Ram's birthplace Ayodhya is in Pakistan?
- Hyderabad: Ayodhya, the birthplace of Hindu warrior-god Ram, is in Pakistan, claims a book by a top Muslim leader. Ayodhya in Faizabad district of Uttar Pradesh is not the original city by the same name as it was inhabited by human beings only in 7th ...
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Brahmanda Purana Topics
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text:
BC Falls To North Carolina StateNorth Carolina State became bowl eligible for the second straight season, cruising to a 24-8 ACC victory and handing Boston College its seventh straight loss on Saturday.
Who Could Celtics Draft At 17?Here's a handful of potential picks for the Celtics with the 17th overall pick in the NBA Draft.
Celtics At 7: Breaking Down NC State's TJ Warren
Top 5 NCAA Final Four Moments EverThe NCAA Final Four has given us many amazing moments in its illustrious history. Here are the top 5.


text:
With a stay at Hotel Regal Enclave, you'll be centrally located in Mumbai, convenient to University of Mumbai and Mt. Mary Church. This hotel is within close proximity of Bandra Kurla Complex and Lilavati Hospital.
Make yourself at home in one of the 34 individually furnished guestrooms, featuring refrigerators and LCD televisions. Your room comes with a memory foam bed. Complimentary wireless Internet access keeps you connected, and satellite programming is available for your entertainment. Private bathrooms have rainfall showerheads and complimentary toiletries.
Pamper yourself with a visit to the spa, which offers massages, body treatments, and facials. If you're looking for recreational opportunities, you'll find a health club and an outdoor pool. Additional features at this hotel include complimentary wireless Internet access, concierge services, and gift shops/newsstands.
Satisfy your appetite at the hotel's restaurant, which serves breakfast, lunch, and dinner. Dining is also available at a coffee shop/café, and 24-hour room service is provided.
Business, Other Amenities
Featured amenities include a 24-hour business center, limo/town car service, and complimentary newspapers in the lobby. A roundtrip airport shuttle is complimentary (available on request).


text:
CONCORD, N.C. (AP) � NASCAR chairman Brian France called Jeremy Mayfield's positive drug test "a serious violation" of the sport's toughened new drug policy.
France said Friday he considers performance-enhancers and recreational drugs to be serious violations. But a person familiar with Mayfield's test results told The Associated Press that Mayfield did not test positive for a performance-enhancing drug.
That means Mayfield tested positive for a narcotic or a controlled substance, such as cocaine, marijuana or methamphetamine.
France would not reveal what Mayfield was caught using, despite a call from several drivers to disclose the drug.
"We had a serious violation of our test, our substance-abuse policy, which gets you an automatic and indefinite suspension and that is where we stand with Jeremy," France said. "We've said it's serious."
Mayfield failed a random drug test conducted May 1 at Richmond International Raceway. He was notified of his test result May 5, which he attributed to a combination of a prescription drug and an over-the-counter medication. NASCAR's drug-testing program administrator has rejected that explanation.
Mayfield then asked for his backup "B'' sample to be tested, and it came back positive last Saturday. NASCAR immediately suspended him as a driver and team owner of Mayfield Motorsports.
But Mayfield's explanation has left many drivers confused and admittedly scared to take any medications for fear of failing drug test.
France tried to reassure the drivers, explaining proper use of over-the-counter medication and prescriptions won't lead to NASCAR punishment.
"If you should test positive for over-the-counter medications or a prescribed medication that you are on with your doctor, that doesn't result in NASCAR suspending you," France said. "You will ... be asked to explain why you have a certain substance that was identified in a test. That's happened a lot, and it doesn't get you a suspension."
NASCAR won't reveal substance in Mayfield test
CONCORD, N.C. (AP) � NASCAR chairman Brian France called Jeremy Mayfield's positive drug test "a serious violation" of the sport's toughened new drug policy.


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Guilt Free Gelt
The gelt we eat on Chanukah is a reminder of the freedom our people won many years ago. Today, however, young children are trafficked and forced into working on cocoa farms with no pay and in unsafe conditions in the Ivory Coast, where more than half the world's cocoa is grown.
This Chanukah, we can support the 65,000 member farmers of Kuapa Kokoo, a Fair Trade cooperative in Ghana who are co-owners of Divine Chocolate. Fair Trade standards prohibit the use of child labor. The organization is democratically run, and their children attend school rather than work in the fields.
Fair Trade Judaica is pleased to be partnering with T'ruah on our Guilt-free Gelt Campaign. Along with your gelt order, you'll receive a table tent with inspirational information and a kavana (prayer) to say before eating the gelt.
Divine Chocolate is donating 10% of all sales to Fair Trade Judaica and T'ruah to support our efforts in ending child slavery in the cocoa fields.
Retail Orders
We have put together a special Chanukah gelt page for you this year!! You can purchase 1 bag of 13 coins, a 10 pack or a 30 pack. No promo code required; just order your gelt from our new page and we receive the 10% donation.
Wholesale and Bulk Orders
You can place your order at http://wholesale.divinechocolateusa.com. Please use promo code GUILTFREEGELT at checkout to assure that we receive 10% of sales. Summer shipping is in effect through September, so you may want to wait until October before placing your order.
Download this kavanah (PDF) for eating Chanukah gelt.
Find fun fair trade Chanukah activities here (song, recipe, farmers, and more)
Click here to see FREE educational resources for your synagogue or organization on Chocolate, Child Labor and Fair Trade.


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"The Rock" Takes A Lot Of Selfies! Just when you think that you can't love him anymore he goes and breaks the Guinness World Record for taking the most selfies in under three minutes.
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Stein Mart — State Road 434 N.,
Altamonte Springs, FL Hours and Location
Category: Department Stores
Department Stores
Hours street map for all businesses nearby.
Stein Mart Hours
Other Stein Mart Locations
Hours for other Altamonte Springs stores...
995 State Road 434 N.,
Altamonte Springs, FL 32714Driving Directions
Founded by the current chairman's grandfather just after the turn of the 20th century, the Stein Mart concept has evolved into a nationwide network of easy-to-access freestanding stores. Our merchandise includes current-season, brand name fashion for women and men; accessories; home decor; linens; and shoes. All are at prices up to 60% below department store prices, every day. Because our customer appreciates variety – and because she likes to be unique – we update merchandise frequently and supply a limited inventory of each item per store.... more
Other Stein Mart Locations
Hours for other Altamonte Springs stores...
As of: 8:04 pm (EDT) Fri Oct 28, 2016. [Change]