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Most Cited Nutrition Research Articles
The most cited articles published since 2011, extracted from Scopus.
Prevalence and correlates of vitamin D deficiency in US adultsKimberly Y Z Forrest | Wendy L. Stuhldreher
Volume 31, Issue 1, January 2011, Pages 48-54
Mounting evidence suggests that vitamin D deficiency could be linked to several chronic diseases, including cardiovascular disease and cancer. The purpose of this study was to examine the prevalence of vitamin D deficiency and its correlates to test the hypothesis that vitamin D deficiency was common in the US population, especially in certain minority groups. The National Health and Nutrition Examination Survey 2005 to 2006 data were analyzed for vitamin D levels in adult participants (N = 4495). Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D concentrations ≤20 ng/mL (50 nmol/L). The overall prevalence rate of vitamin D deficiency was 41.6%, with the highest rate seen in blacks (82.1%), followed by Hispanics (69.2%). Vitamin D deficiency was significantly more common among those who had no college education, were obese, with a poor health status, hypertension, low high-density lipoprotein cholesterol level, or not consuming milk daily (all P < .001). Multivariate analyses showed that being from a non-white race, not college educated, obese, having low high-density lipoprotein cholesterol, poor health, and no daily milk consumption were all significantly, independently associated with vitamin D deficiency (all P < .05). In summary, vitamin D deficiency was common in the US population, especially among blacks and Hispanics. Given that vitamin D deficiency is linked to some of the important risk factors of leading causes of death in the United States, it is important that health professionals are aware of this connection and offer dietary and other intervention strategies to correct vitamin D deficiency, especially in minority groups. © 2011 Elsevier Inc.
Chemopreventive effect of dietary polyphenols in colorectal cancer cell linesJoão R. Araújo | Pedro Gonçalves | Fátima Martel
Volume 31, Issue 2, February 2011, Pages 77-87
Colorectal cancer (CRC) is the second most fatal and the third most diagnosed type of cancer worldwide. Despite having multifactorial causes, most CRC cases are mainly determined by dietary factors. In recent years, a large number of studies have attributed a protective effect to polyphenols and foods containing these compounds (fruits and vegetables) against CRC. Indeed, polyphenols have been reported to interfere with cancer initiation, promotion, and progression, acting as chemopreventive agents. The aim of this review is to summarize the main chemopreventive properties of some polyphenols (quercetin, rutin, myricetin, chrysin, epigallocatechin-3-gallate, epicatechin, catechin, resveratrol, and xanthohumol) against CRC, observed in cell culture models. From the data reviewed in this article, it can be concluded that these compounds inhibit cell growth, by inducing cell cycle arrest and/or apoptosis; inhibit proliferation, angiogenesis, and/or metastasis; and exhibit anti-inflammatory and/or antioxidant effects. In turn, these effects involve multiple molecular and biochemical mechanisms of action, which are still not completely characterized. Thus, caution is mandatory when attempting to extrapolate the observations obtained in CRC cell line studies to humans. © 2011 Elsevier Inc.
Resveratrol supplementation improves glycemic control in type 2 diabetes mellitusJayesh Kumar Bhatt | Sabin Thomas | Moola Joghee Nanjan
Volume 32, Issue 7, July 2012, Pages 537-541
Resveratrol is a naturally occurring polyphenolic compound. Numerous animal studies have been reported on its wide-ranging beneficial effects in the biological system including diabetes mellitus (DM). We hypothesized, therefore, that oral supplementation of resveratrol would improve the glycemic control and the associated risk factors in patients with type 2 diabetes mellitus (T2DM). The present clinical study was therefore carried out to test the hypothesis. Sixty-two patients with T2DM were enrolled from Government Headquarters Hospital, Ootacamund, India, in a prospective, open-label, randomized, controlled trial. Patients were randomized into control and intervention groups. The control group received only oral hypoglycemic agents, whereas the intervention group received resveratrol (250 mg/d) along with their oral hypoglycemic agents for a period of 3 months. Hemoglobin A1c, lipid profile, urea nitrogen, creatinine, and protein were measured at the baseline and at the end of 3 months. The results reveal that supplementation of resveratrol for 3 months significantly improves the mean hemoglobin A1c (means ± SD, 9.99 ± 1.50 vs 9.65 ± 1.54; P < .05), systolic blood pressure (mean ± SD, 139.71 ± 16.10 vs 127.92 ± 15.37; P < .05), total cholesterol (mean ± SD, 4.70 ± 0.90 vs 4.33 ± 0.76; P < .05), and total protein (mean ± SD, 75.6 ± 4.6 vs 72.3 ± 6.2; P < .05) in T2DM. No significant changes in body weight and high-density lipoprotein and low-density lipoprotein cholesterols were observed. Oral supplementation of resveratrol is thus found to be effective in improving glycemic control and may possibly provide a potential adjuvant for the treatment and management of diabetes. © 2012 Elsevier Inc.
Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patientsPawel Bogdanski | Joanna Suliburska | Monika Szulinska | Marta Stepien | Danuta Pupek-Musialik | Anna Jablecka
Volume 32, Issue 6, June 2012, Pages 421-427
Green tea (GT) consumption is known to be associated with enhanced cardiovascular and metabolic health. The purpose of this study is to examine the hypothesis that supplementation with GT alters insulin resistance and associated cardiovascular risk factors in obese, hypertensive patients. In a double-blind, placebo-controlled trial, 56 obese, hypertensive subjects were randomized to receive a daily supplement of 1 capsule that contained either 379 mg of GT extract (GTE) or a matching placebo, for 3 months. At baseline and after 3 months of treatment, the anthropometric parameters, blood pressure, plasma lipid levels, glucose levels, creatinine levels, tumor necrosis factor α levels, C-reactive protein levels, total antioxidant status, and insulin levels were assessed. Insulin resistance was evaluated according to the homeostasis model assessment-insulin resistance protocol. After 3 months of supplementation, both systolic and diastolic blood pressures had significantly decreased in the GTE group as compared with the placebo group (P < .01). Considerable (P < .01) reductions in fasting serum glucose and insulin levels and insulin resistance were observed in the GTE group when compared with the placebo group. Serum tumor necrosis factor α and C-reactive protein were significantly lower, whereas total antioxidant status increased in the GTE group compared with the placebo (P < .05). Supplementation also contributed to significant (P < .05) decreases in the total and low-density lipoprotein cholesterol and triglycerides, but an increase in high-density lipoprotein cholesterol. In conclusion, daily supplementation with 379 mg of GTE favorably influences blood pressure, insulin resistance, inflammation and oxidative stress, and lipid profile in patients with obesity-related hypertension. © 2012 Elsevier Inc.
A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancerChristina D. Williams | Brian M. Whitley | Cathrine Hoyo | Delores J. Grant | Jared D. Iraggi | Kathryn A. Newman | Leah Gerber | Loretta A. Taylor | Madeline G. McKeever | Stephen J. Freedland
Volume 31, Issue 1, January 2011, Pages 1-8
Experimental studies suggest omega-3 (n-3) polyunsaturated fatty acids (PUFA) suppress and n-6 PUFA promote prostate tumor carcinogenesis. Epidemiologic evidence remains inconclusive. The objectives of this study were to examine the association between n-3 and n-6 PUFA and prostate cancer risk and determine if these associations differ by race or disease aggressiveness. We hypothesize that high intakes of n-3 and n-6 PUFA will be associated with lower and higher prostate cancer risk, respectively. A case-control study comprising 79 prostate cancer cases and 187 controls was conducted at the Durham VA Medical Center. Diet was assessed using a food frequency questionnaire. Logistic regression analyses were used to obtain odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations between n-3 and n-6 PUFA intakes, the dietary ratio of n-6/n-3 fatty acids, and prostate cancer risk. Our results showed no significant associations between specific n-3 or n-6 PUFA intakes and prostate cancer risk. The highest dietary ratio of n-6/n-3 was significantly associated with elevated risk of high-grade (OR, 3.55; 95% CI, 1.18-10.69; P trend = 0.03), but not low-grade prostate cancer (OR, 0.95; 95% CI, 0.43-2.17). In race-specific analyses, an increasing dietary ratio of n-6/n-3 fatty acids correlated with higher prostate cancer risk among white men (P trend = 0.05), but not black men. In conclusion, our findings suggest that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase the risk of high-grade prostate cancer among all men. © 2011 Elsevier Inc.
Potential mechanisms for the emerging link between obesity and increased intestinal permeabilityTatiana F S Teixeira | Maria Carmen Collado | Célia L L F Ferreira | Josefina Bressan | Maria do Carmo G Peluzio
Volume 32, Issue 9, September 2012, Pages 637-647
Recently, increased attention has been paid to the link between gut microbial composition and obesity. Gut microbiota is a source of endotoxins whose increase in plasma is related to obesity and insulin resistance through increased intestinal permeability in animal models; however, this relationship still needs to be confirmed in humans. That intestinal permeability is subject to change and that it might be the interface between gut microbiota and endotoxins in the core of metabolic dysfunctions reinforce the need to understand the mechanisms involved in these aspects to direct more efficient therapeutic approaches. Therefore, in this review, we focus on the emerging link between obesity and increased intestinal permeability, including the possible factors that contribute to increased intestinal permeability in obese subjects. We address the concept of intestinal permeability, how it is measured, and the intestinal segments that may be affected. We then describe 3 factors that may have an influence on intestinal permeability in obesity: microbial dysbiosis, dietary pattern (high-fructose and high-fat diet), and nutritional deficiencies. Gaps in the current knowledge of the role of Toll-like receptors ligands to induce insulin resistance, the routes for lipopolysaccharide circulation, and the impact of altered intestinal microbiota in obesity, as well as the limitations of current permeability tests and other potential useful markers, are discussed. More studies are needed to reveal how changes occur in the microbiota. The factors such as changes in the dietary pattern and the improvement of nutritional deficiencies appear to influence intestinal permeability, and impact metabolism must be examined. Also, additional studies are necessary to better understand how probiotic supplements, prebiotics, and micronutrients can improve stress-induced gastrointestinal barrier dysfunction and the influence these factors have on host defense. Hence, the topics presented in this review may be beneficial in directing future studies that assess gut barrier function in obesity. © 2012 Elsevier Inc.
Tualang honey has higher phenolic content and greater radical scavenging activity compared with other honey sourcesR. Krishna Kishore | Ahmad Sukari Halim | M. S Nurul Syazana | K. N S Sirajudeen
Volume 31, Issue 4, April 2011, Pages 322-325
Many chronic diseases are associated with increased oxidative stress caused by an imbalance between free-radical production and the antioxidant level. Antioxidants, which are abundant in natural honey, are free-radical scavengers that either reduce the formation of or neutralize free radicals. The composition and source of honey greatly dictates its biochemical properties. We performed a comparative analysis of the total phenolic content and antioxidant potential of common commercially available honeys along with Malaysian tualang honey. In vitro biochemical analysis of the phenolic content by the Folin-Ciocalteau method revealed a significantly elevated phenolic content (83.96 ± 4.53 mg gallic acid equivalents per 100 g) in tualang honey. In addition, the antioxidant capacity (53.06 ± 0.41 mg ascorbic acid equivalents per gram) of tualang honey was greater, as assessed by the phosphomolybdenum method, 2,2-diphenyl-1-picryl-hydrazyl assay, and ferric reducing/antioxidant power assay. Peroxynitrite and superoxide radical scavenging activity was determined by spectrophotometric analysis in different honey types. Our data suggest that the elevated free-radical scavenging and antioxidant activity observed in tualang honey is due to the increased level of phenolic compounds. In addition to its antibacterial, anticarcinogenic, and anti-inflammatory properties, our study highlights the favorable antioxidant properties of tualang honey, which may be important to human nutrition and health. © 2011 Elsevier Inc.
Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndromeArpita Basu | Nancy M. Betts | Jennifer Ortiz | Brandi Simmons | Mingyuan Wu | Timothy J. Lyons
Volume 31, Issue 3, March 2011, Pages 190-196
Cranberries, high in polyphenols, have been associated with several cardiovascular health benefits, although limited clinical trials have been reported to validate these findings. We tested the hypothesis that commercially available low-energy cranberry juice (Ocean Spray Cranberries, Inc, Lakeville-Middleboro, Mass) will decrease surrogate risk factors of cardiovascular disease, such as lipid oxidation, inflammation, and dyslipidemia, in subjects with metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, participants identified with metabolic syndrome (n = 15-16/group) were assigned to 1 of 2 groups: cranberry juice (480 mL/day) or placebo (480 mL/day) for 8 weeks. Anthropometrics, blood pressure measurements, dietary analyses, and fasting blood draws were conducted at screen and 8 weeks of the study. Cranberry juice significantly increased plasma antioxidant capacity (1.5 ± 0.6 to 2.2 ± 0.4 μmol/L [means ± SD], P < .05) and decreased oxidized low-density lipoprotein and malondialdehyde (120.4 ± 31.0 to 80.4 ± 34.6 U/L and 3.4 ± 1.1 to 1.7 ± 0.7 μmol/L, respectively [means ± SD], P < .05) at 8 weeks vs placebo. However, cranberry juice consumption caused no significant improvements in blood pressure, glucose and lipid profiles, C-reactive protein, and interleukin-6. No changes in these parameters were noted in the placebo group. In conclusion, low-energy cranberry juice (2 cups/day) significantly reduces lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. © 2011 Elsevier Inc.
Diet promotes sleep duration and qualityKatri Peuhkuri | Nora Sihvola | Riitta Korpela
Volume 32, Issue 5, May 2012, Pages 309-319
Sleep, much like eating, is an essential part of life. The mechanisms of sleep are only partially clear and are the subject of intense research. There is increasing evidence showing that sleep has an influence on dietary choices. Both cross-sectional and epidemiologic studies have demonstrated that those who sleep less are more likely to consume energy-rich foods (such as fats or refined carbohydrates), to consume fewer portions of vegetables, and to have more irregular meal patterns. In this narrative review, we pose the opposite question: can ingested food affect sleep? The purpose of this review is to discuss the evidence linking diet and sleep and to determine whether what we eat and what kind of nutrients we obtain from the food consumed before bedtime matter. In addition, scientific evidence behind traditional sleep-promoting foods such as milk and some herbal products is briefly described. These are reviewed using data from clinical trials, mostly in healthy subjects. In addition, we discuss the possible mechanisms behind these observations. Lastly, we summarize our findings that emerging evidence confirms a link between diet and sleep. Overall, foods impacting the availability of tryptophan, as well as the synthesis of serotonin and melatonin, may be the most helpful in promoting sleep. Although there are clear physiological connections behind these effects, the clinical relevance needs to be studied further. © 2012 Elsevier Inc..
Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatmentKeisuke Fujitaka | Hajime Otani | Fusakazu Jo | Hiromi Jo | Emiko Nomura | Masayoshi Iwasaki | Mitsushige Nishikawa | Toshiji Iwasaka | Dipak K. Das
Volume 31, Issue 11, November 2011, Pages 842-847
Resveratrol is known to improve endothelial function in animals, but little is known about its effect on human subjects. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors underlying endothelial dysfunction. We hypothesized that the modified resveratrol, Longevinex, improves endothelial function in patients with MetS. Thirty-four patients who had been treated for MetS and lifestyle-related disease were randomly assigned to group A, in which Longevinex was administered for 3 months and then discontinued for 3 months, whereas in the time-matched group B, Longevinex was administered between 3 and 6 months. These 2 groups of patients received similar drugs at baseline for diabetes mellitus, dyslipidemia, or hypertension. Flow-mediated dilatation significantly increased during the administration of Longevinex but decreased to baseline 3 months after the discontinuation of Longevinex in the group A patients. Conversely, in the group B patients, flow-mediated dilatation remained unchanged for the first 3 months without Longevinex but was significantly increased 3 months after the treatment with Longevinex. Longevinex did not significantly affect blood pressure, insulin resistance, the lipid profile or inflammatory markers during 6-month follow-up. These results demonstrate that Longevinex specifically improves endothelial function in subjects with MetS who were receiving standard therapy for lifestyle-related disease. © 2011 Elsevier Inc.
Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese miceYong Pil Hwang | Jae Ho Choi | Eun Hee Han | Hyung Gyun Kim | Ji Hyang Wee | Kyung Ok Jung | Kyung Hee Jung | Kwang il Kwon | Tae Cheon Jeong | Young Chul Chung | Hye Gwang Jeong
Volume 31, Issue 12, December 2011, Pages 896-906
Purple sweet potato is a functional food rich in anthocyanins that possess disease-preventive properties. Anthocyanins are known to possess potent antidiabetic properties. However, the effect of the anthocyanin fraction (AF) from purple sweet potato on hepatic lipid metabolism remains unclear. Our hypothesis is that AF inhibits hepatic lipid accumulation through the activation of adenosine monophosphate-activated protein kinase (AMPK) signaling pathways in vitro and in vivo. In this study, we evaluated body weight, liver histology, and hepatic lipid content in high-fat diet (HFD)-fed ICR mice treated with AF. In addition, we characterized the underlying mechanism of AF's effects in HepG2 hepatocytes through Western blot analysis. Anthocyanin fraction (200 mg/kg per day) reduced weight gain and hepatic triglyceride accumulation and improved serum lipid parameters in mice fed an HFD for 4 weeks. Anthocyanin fraction significantly increased the phosphorylation of AMPK and acetyl-coenzyme A carboxylase (ACC) in the liver and HepG2 hepatocytes. In addition, AF down-regulated the levels of sterol regulatory element-binding protein 1 and its target genes including ACC and fatty acid synthase (FAS). The specific AMPK inhibitor compound C attenuated the effects of AF on the expression of lipid metabolism-related proteins such as SREBP-1 and FAS in HepG2 hepatocytes. The beneficial effects of AF on HFD-induced hepatic lipid accumulation are thus mediated through AMPK signaling pathways, suggesting a potential target for the prevention of obesity. © 2011 Elsevier Inc.
Review of the association between meat consumption and risk of colorectal cancerEunjung Kim | Desire Coelho | François Blachier
Volume 33, Issue 12, December 2013, Pages 983-994
The incidence of colorectal cancer (CRC) is rapidly increasing in developing countries, especially among populations that are adopting Western-style diets. Several, but not all, epidemiological and experimental studies suggest that a high intake of meat, especially red and processed meat, is associated with increased CRC risk. Potential reasons for the association between high red and processed meat intake and CRC risk include the content of the meat (e.g. protein, heme) and compounds generated by the cooking process (e.g. N-nitroso compounds, heterocyclic amines). These factors can affect the large intestine mucosa with genotoxicity and metabolic disturbances. Increased bacterial fermentation (putrefaction) of undigested protein and production of bacterial metabolites derived from amino acids may affect colon epithelial homeostasis and renewal. This correlates with the fact that most colonic cancers are detected in the distal colon and rectum where protein fermentation actively occurs. However, there are still large controversies on the relationship between red meat consumption and CRC risk. Therefore, the purpose of this review is to enhance the current understanding on the association between high red and processed meat intakes with CRC risk. A principal focus of this review will be to discuss the meat-related components, such as proteins in the meat, heme, N-nitroso compounds, and heterocyclic amines, and the effects they have upon the large intestine mucosa and the intestinal gut microbiota. © 2013 Elsevier Inc.
Yogurt consumption is associated with better diet quality and metabolic profile in American men and womenHuifen Wang | Kara A. Livingston | Caroline S. Fox | James B. Meigs | Paul F. Jacques
Volume 33, Issue 1, January 2013, Pages 18-26
The evidence-based Dietary Guidelines for Americans recommends increasing the intake of fat-free or low-fat milk and milk products. However, yogurt, a nutrient-dense milk product, has been understudied. This cross-sectional study examined whether yogurt consumption was associated with better diet quality and metabolic profile among adults (n = 6526) participating in the Framingham Heart Study Offspring (1998-2001) and Third Generation (2002-2005) cohorts. A validated food frequency questionnaire was used to assess dietary intake, and the Dietary Guidelines Adherence Index (DGAI) was used to measure overall diet quality. Standardized clinical examinations and laboratory tests were conducted. Generalized estimating equations examined the associations of yogurt consumption with diet quality and levels of metabolic factors. Approximately 64% of women (vs 41% of men) were yogurt consumers (ie, consumed >0 servings/week). Yogurt consumers had a higher DGAI score (ie, better diet quality) than nonconsumers. Adjusted for demographic and lifestyle factors and DGAI, yogurt consumers, compared with nonconsumers, had higher potassium intakes (difference, 0.12 g/d) and were 47%, 55%, 48%, 38%, and 34% less likely to have inadequate intakes (based on Dietary Reference Intake) of vitamins B2 and B12, calcium, magnesium, and zinc, respectively (all P ≤ .001). In addition, yogurt consumption was associated with lower levels of circulating triglycerides, glucose, and lower systolic blood pressure and insulin resistance (all P < .05). Yogurt is a good source of several micronutrients and may help to improve diet quality and maintain metabolic well-being as part of a healthy, energy-balanced dietary pattern. © 2013 Elsevier Inc.
Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver diseaseForouzan Faghihzadeh | Peyman Adibi | Rahmatollah Rafiei | Azita Hekmatdoost
Volume 34, Issue 10, January 2014, Pages 837-843
© 2014 Elsevier Inc.Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Resveratrol is a polyphenolic compound with antioxidant capacity that shows beneficial effects on down-regulation of inflammatory mediators and metabolic disorders. We hypothesized that supplementation with resveratrol can further improve the efficacy of lifestyle modifications in the management of NAFLD. In this randomized, double-blinded, controlled clinical trial, 50 NAFLD patients were supplemented with either a 500-mg resveratrol capsule or a placebo capsule for 12 weeks. Both groups were advised to follow an energy-balanced diet and received physical activity recommendations. Serum liver enzymes, inflammatory markers, hepatic steatosis and fibrosis, dietary intake, anthropometric measurements, and physical activity were assessed at both baseline and the end of the study. In both groups, anthropometric measurements (weight, body mass index, waist circumference), liver enzymes, and steatosis grade improved (. P < 005). Resveratrol supplementation was associated with a significant reduction in liver enzyme alanine aminotransferase, inflammatory cytokines, nuclear factor κB activity, serum cytokeratin-18, and hepatic steatosis grade, as compared with placebo supplementation (. P < .05). For the treatment of NAFLD, our results showed that 12 weeks of supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone. This is at least partially due to the attenuation of inflammatory markers and hepatocellular apoptosis. More studies are needed to confirm and increase the clinical application of the present results.
Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α-negative breast cellsHye Sook Seo | Ji hyun Ju | Kibeom Jang | Incheol Shin
Volume 31, Issue 2, February 2011, Pages 139-146
In this study, we investigated the underlying mechanism by which phytoestrogens suppress the growth of normal (MCF-10A) and malignant (MDA-MB-231) estrogen receptor α (ER. α)-negative breast cells. We hypothesized that phytoestrogen inhibits the proliferation of ER. α-negative breast cancer cells. We found that all tested phytoestrogens (genistein, apigenin, and quercetin) suppressed the growth of both MCF-10A and MDA-MB-231 cells, as revealed by proliferation assays. These results were accompanied by an increase in the sub-G0/G1 apoptotic fractions as well as an increase in the cell population in the G2/M phase in both cell types, as revealed by cell cycle analysis. When we assessed the effect of phytoestrogens on the level of intracellular signaling molecules by Western blot analysis, we found that phytoestrogens increased the level of active p53 (phospho-p53) without changing the p53 level in both MCF-10A and MDA-MB-231 cells. Phytoestrogens also induced an increase in p21, a p53 target gene, and a decrease in either Bcl-xL or cyclin B1 in both cell types. In contrast, the protein levels of phosphatase and tensin homolog, cyclin D1, cell division control protein 2 homolog, phospho-cell division control protein 2 homolog, and p27 were not changed after phytoestrogen treatment. Our data indicate that phytoestrogens induce apoptotic cell death of ER. α-negative breast cancer cells via p53-dependent pathway and suggest that phytoestrogens may be promising agents in the treatment and prevention of ER. α-negative breast cancer. © 2011 Elsevier Inc.
Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: The Third National Health and Nutrition Examination SurveyMichelle D. Shardell | Dawn E. Alley | Gregory E. Hicks | Samer S. El-Kamary | Ram R. Miller | Richard D. Semba | Luigi Ferrucci
Volume 31, Issue 3, March 2011, Pages 178-189
Evidence regarding the health benefits of carotenoids is controversial. Effects of serum carotenoids and their interactions on mortality have not been examined in a representative sample of US adults. The objective was to examine whether serum carotenoid concentrations predict mortality among US adults. The study consisted of adults aged ≥20 years enrolled in the Third National Health and Nutrition Examination Survey, 1988 to 1994, with measured serum carotenoids and mortality follow-up through 2006 (N = 13 293). Outcomes were all-cause, cardiovascular disease, and cancer mortality. In adjusted Cox proportional hazards models, participants in the lowest total carotenoid quartile (<1.01
1.75 μmol/L). For α-carotene, the highest quartile (>0.11 μmol/L) had the lowest all-cause mortality rates (P < .001). For lycopene, the middle 2 quartiles (0.29-0.58 μmol/L) had the lowest all-cause mortality rates (P = .047). Analyses with continuous carotenoids confirmed associations of serum total carotenoids, α-carotene, and lycopene with all-cause mortality (P < .001). In a random survival forest analysis, very low lycopene was the carotenoid most strongly predictive of all-cause mortality, followed by very low total carotenoids. α-Carotene/ β-cryptoxanthin, α-carotene/lutein+zeaxanthin and lycopene/lutein+zeaxanthin interactions were significantly related to all-cause mortality (P < .05). Low α-carotene was the only carotenoid associated with cardiovascular disease mortality (P = .002). No carotenoids were significantly associated with cancer mortality. Very low serum total carotenoid, α-carotene, and lycopene concentrations may be risk factors for mortality, but carotenoids show interaction effects on mortality. Interventions of balanced carotenoid combinations are needed for confirmation. © 2011 Elsevier Inc.
Resveratrol role in cardiovascular and metabolic health and potential mechanisms of actionQiang Xu | Liang Yi Si
Volume 32, Issue 9, September 2012, Pages 648-658
Resveratrol is a polyphenolic flavonoid found in a diversity of plants, especially berry fruits and is a popular nutritional supplement. It is known to have antioxidant, anti-inflammatory, and anticarcinogenic properties. Recently, additional evidence has been found that resveratrol is beneficial to metabolic and cardiovascular health and may increase the life expectancy of various organisms. These biological effects are widely believed to be due to the ability of resveratrol to activate silent mating-type information regulation 2 homolog 1, a nicotinamide adenine dinucleotide-dependent deacetylase. However, other research has shown that 5'-adenosine monophosphate-activated kinase and not silent mating-type information regulation 2 homolog 1 may be the target of resveratrol. A recent study reported that resveratrol directly inhibits cyclic adenosine monophosphate-specific phosphodiesterases and then activates 5'-adenosine monophosphate-activated kinase. Therefore, the mechanism underlying the diverse nutritional and therapeutic activities of resveratrol needs to be further explored. Furthermore, the optimal dose and possible adverse effects of resveratrol in humans are completely clear. The purpose of this review is to present some of the newly discovered biological effects of resveratrol, including autophagy and stem cell regulation, and research opportunities for the application of resveratrol in cardiovascular and metabolic health. Described herein is the recent understanding of the mechanism of action of resveratrol and future research directions to ascertain the potential of this flavonoid that is present in food. © 2012 Elsevier Inc.
Pomegranate and type 2 diabetesSaleem Banihani | Samer Swedan | Ziyad Alguraan
Volume 33, Issue 5, May 2013, Pages 341-348
Over the last decade, various studies have linked pomegranate (Punica granatum Linn), a fruit native to the Middle East, with type 2 diabetes prevention and treatment. This review focuses on current laboratory and clinical research related to the effects of pomegranate fractions (peels, flowers, and seeds) and some of their active components on biochemical and metabolic variables associated with the pathologic markers of type 2 diabetes. This review systematically presents findings from cell culture and animal studies as well as clinical human research. One key mechanism by which pomegranate fractions affect the type 2 diabetic condition is by reducing oxidative stress and lipid peroxidation. This reduction may occur by directly neutralizing the generated reactive oxygen species, increasing certain antioxidant enzyme activities, inducing metal chelation activity, reducing resistin formation, and inhibiting or activating certain transcriptional factors, such as nuclear factor κB and peroxisome proliferator-activated receptor γ. Fasting blood glucose levels were decreased significantly by punicic acid, methanolic seed extract, and pomegranate peel extract. Known compounds in pomegranate, such as punicalagin and ellagic, gallic, oleanolic, ursolic, and uallic acids, have been identified as having anti-diabetic actions. Furthermore, the juice sugar fraction was found to have unique antioxidant polyphenols (tannins and anthocyanins), which could be beneficial to control conditions in type 2 diabetes. These findings provide evidence for the anti-diabetic activity of pomegranate fruit; however, before pomegranate or any of its extracts can be medically recommended for the management of type 2 diabetes, controlled, clinical studies, are needed. © 2013 Elsevier Inc.
Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat dietMorten Møller Poulsen | Jens Larsen | Stephen Hamilton-Dutoit | Berthil F. Clasen | Niels Jessen | Søren K. Paulsen | Thomas N. Kjær | Bjørn Richelsen | Steen B. Pedersen
Volume 32, Issue 9, September 2012, Pages 701-708
Obesity is associated with a markedly increased risk of nonalcoholic fatty liver disease. The anti-inflammatory polyphenol resveratrol possess promising properties in preventing this metabolic condition by dampening the pathological inflammatory reaction in the hepatic tissue. However, in the current study, we hypothesize that the beneficial effect of resveratrol is not solely attributable to its anti-inflammatory potential. Eight-week-old male Wistar rats were randomly distributed into 3 groups of 12 animals each: control diet (C), high-fat diet (HF), and HF supplemented with 100 mg resveratrol daily (HFR). After 8 weeks of dietary treatment, the rats were euthanized and relevant tissues were prepared for subsequent analysis. Resveratrol prevented the high fat-induced steatosis assessed by semiquantitative grading, which furthermore corresponded with a complete normalization of the hepatic triglyceride content (P < .001), despite no change in total body fat. In HFR, the hepatic uncoupling protein 2 expression was significantly increased by 76% and 298% as compared with HF and C, respectively. Moreover, the hepatic mitochondria content in HFR was significantly higher as compared with both C and HF (P < .001 and P = .004, respectively). We found no signs of hepatic inflammation, hereby demonstrating that resveratrol protects against fatty liver disease independently of its proposed anti-inflammatory potential. Our data might indicate that an increased number of mitochondria and, particularly, an increase in hepatic uncoupling protein 2 expression are involved in normalizing the hepatic fat content due to resveratrol supplementation in rodents fed a high-fat diet. © 2012 Elsevier Inc.
Review of natural products actions on cytokines in inflammatory bowel diseaseSun Jin Hur | Sung Ho Kang | Ho Sung Jung | Sang Chul Kim | Hyun Soo Jeon | Ick Hee Kim | Jae Dong Lee
Volume 32, Issue 11, November 2012, Pages 801-816
The purpose of this review is to provide an overview of the effects that natural products have on inflammatory bowel disease (IBD) and to provide insight into the relationship between these natural products and cytokines modulation. More than 100 studies from the past 10 years were reviewed herein on the therapeutic approaches for treating IBD. The natural products having anti-IBD actions included phytochemicals, antioxidants, microorganisms, dietary fibers, and lipids. The literature revealed that many of these natural products exert anti-IBD activity by altering cytokine production. Specifically, phytochemicals such as polyphenols or flavonoids are the most abundant, naturally occurring anti-IBD substances. The anti-IBD effects of lipids were primarily related to the n-3 polyunsaturated fatty acids. The anti-IBD effects of phytochemicals were associated with modulating the levels of tumor necrosis factor α (TNF-α), interleukin (IL)-1, IL-6, inducible nitric oxide synthase, and myeloperoxide. The anti-IBD effects of dietary fiber were mainly mediated via peroxisome proliferator-activated receptor-γ, TNF-α, nitric oxide, and IL-2, whereas the anti-IBD effects of lactic acid bacteria were reported to influence interferon-γ, IL-6, IL-12, TNF-α, and nuclear factor-κ light-chain enhancer of activated B cells. These results suggest that the anti-IBD effects exhibited by natural products are mainly caused by their ability to modulate cytokine production. However, the exact mechanism of action of natural products for IBD therapy is still unclear. Thus, future research is needed to examine the effect of these natural products on IBD and to determine which factors are most strongly correlated with reducing IBD or controlling the symptoms of IBD. © 2012 Elsevier Inc..
Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel ReportJoshua A. Boyce | Amal Assa'ad | A. Wesley Burks | Stacie M. Jones | Hugh A. Sampson | Robert A. Wood | Marshall Plaut | Susan F. Cooper | Matthew J. Fenton | S. Hasan Arshad | Sami L. Bahna | Lisa A. Beck | Carol Byrd-Bredbenner | Carlos A. Camargo | Lawrence Eichenfield | Glenn T. Furuta | Jon M. Hanifin | Carol Jones | Monica Kraft | Bruce D. Levy | Phil Lieberman | Stefano Luccioli | Kathleen M. McCall | Lynda C. Schneider | Ronald A. Simon | F. Estelle R Simons | Stephen J. Teach | Barbara P. Yawn | Julie M. Schwaninger
Volume 31, Issue 1, January 2011, Pages 61-75
Total dietary fiber intakes in the US population are related to whole grain consumption: Results from the National Health and Nutrition Examination Survey 2009 to 2010Marla Reicks | Satya Jonnalagadda | Ann M. Albertson | Nandan Joshi
Volume 34, Issue 3, January 2014, Pages 226-234
Whole grain (WG) foods have been shown to reduce chronic disease risk and overweight. Total dietary fiber is associated with WG and its health benefits. The purpose was to determine whether associations exist between WG intake (no-WG intake, 0 ounce equivalent [oz eq]; low, >0-<3 oz eq; high, ≥3 oz eq) and total dietary fiber intake among Americans 2 years and older. One-day food intake data from the US National Health and Nutrition Examination Survey 2009 to 2010 (n = 9042) showed that only 2.9% and 7.7% of children/adolescents (2-18 years) and adults (≥19 years) consumed at least 3 WG oz eq/d, respectively. For children/adolescents and adults, individuals in the high WG intake group were 59 and 76 times more likely to fall in the third fiber tertile, respectively, compared with those with no-WG intake. Total dietary fiber intake from food sources varied by WG intake group for children/adolescents and adults with more total dietary fiber consumed from ready-to-eat (RTE) and hot cereals and yeast breads/rolls in the high WG intake group compared with the no-WG intake group. Major WG sources for children/adolescents and adults included yeast bread/rolls (24% and 27%, respectively), RTE cereals (25% and 20%, respectively), and oatmeal (12% and 21%, respectively). Among those with the highest WG intake, WG RTE cereal with no added bran was the greatest contributor to total dietary fiber compared with other RTE cereal types. Whole grain foods make a substantial contribution to total dietary fiber intake and should be promoted to meet recommendations. © 2014 The Authors.
Carotenoids, inflammation, and oxidative stress-implications of cellular signaling pathways and relation to chronic disease preventionAnouk Kaulmann | Torsten Bohn
Volume 34, Issue 11, January 2014, Pages 907-929
© 2014 Elsevier Inc.Several epidemiologic studies have shown that diets rich in fruits and vegetables reduce the risk of developing several chronic diseases, such as type 2 diabetes, atherosclerosis, and cancer. These diseases are linked with systemic, low-grade chronic inflammation. Although controversy persists on the bioactive ingredients, several secondary plant metabolites have been associated with these beneficial health effects. Carotenoids represent the most abundant lipid-soluble phytochemicals, and in vitro and in vivo studies have suggested that they have antioxidant, antiapoptotic, and anti-inflammatory properties. Recently, many of these properties have been linked to the effect of carotenoids on intracellular signaling cascades, thereby influencing gene expression and protein translation. By blocking the translocation of nuclear factor κB to the nucleus, carotenoids are able to interact with the nuclear factor κB pathway and thus inhibit the downstream production of inflammatory cytokines, such as interleukin-8 or prostaglandin E2. Carotenoids can also block oxidative stress by interacting with the nuclear factor erythroid 2-related factor 2 pathway, enhancing its translocation into the nucleus, and activating phase II enzymes and antioxidants, such as glutathione-. S-transferases. In this review, which is organized into in vitro, animal, and human investigations, we summarized current knowledge on carotenoids and metabolites with respect to their ability to modulate inflammatory and oxidative stress pathways and discuss potential dose-health relations. Although many pathways involved in the bioactivity of carotenoids have been revealed, future research should be directed toward dose-response relations of carotenoids, their metabolites, and their effect on transcription factors and metabolism.
Nutrients from dairy foods are difficult to replace in diets of Americans: Food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003-2006Victor L. Fulgoni | Debra R. Keast | Nancy Auestad | Erin E. Quann
Volume 31, Issue 10, October 2011, Pages 759-765
Because dairy products provide shortfall nutrients (eg, calcium, potassium, and vitamin D) and other important nutrients, this study hypothesized that it would be difficult for Americans to meet nutritional requirements for these nutrients in the absence of dairy product consumption or when recommended nondairy calcium sources are consumed. To test this hypothesis, MyPyramid dietary pattern modeling exercises and an analyses of data from the National Health and Nutrition Examination Survey 2003-2006 were conducted in those aged at least 2 years (n = 16 822). Impact of adding or removing 1 serving of dairy, removing all dairy, and replacing dairy with nondairy calcium sources was evaluated. Dietary pattern modeling indicated that at least 3 servings of dairy foods are needed to help individuals meet recommendations for nutrients, such as calcium and magnesium, and 4 servings may be needed to help some groups meet potassium recommendations. A calcium-equivalent serving of dairy requires 1.1 servings of fortified soy beverage, 0.6 serving of fortified orange juice, 1.2 servings of bony fish, or 2.2 servings of leafy greens. The replacement of dairy with calcium-equivalent foods alters the overall nutritional profile of the diet and affects nutrients including protein, potassium, magnesium, phosphorus, riboflavin, vitamins A, D and B 12. Similar modeling exercises using consumption data from the National Health and Nutrition Examination Survey also demonstrated that nondairy calcium replacement foods are not a nutritionally equivalent substitute for dairy products. In conclusion, although it is possible to meet calcium intake recommendations without consuming dairy foods, calcium replacement foods are not a nutritionally equivalent substitute for dairy foods and consumption of a calcium-equivalent amount of some nondairy foods is unrealistic. © 2011 Elsevier Inc.
Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetesTing Lu | Hongguang Sheng | Johnna Wu | Yuan Cheng | Jianming Zhu | Yan Chen
Volume 32, Issue 6, June 2012, Pages 408-412
For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A 1c and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A 1c and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes. © 2012 Elsevier Inc.


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Hundreds of men fought government forces in the town of Jisr al-Shughur yesterday, according to Syrian television, in the first armed battle against President Assad's troops since the rebellion began two months ago.
The report, which claimed that the rebels had killed 120 policemen, was impossible to verify. It nevertheless raised fears that the regime's violent suppression of civilian protesters risks turning the uprising into an armed insurrection, possibly leading to civil war.
"This is the latest sign that this is going to get much, much worse," Andrew Tabler, a Syria specialist at the Washington Institute, said.
According to the

subset: commoncrawl


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The English Premier League will break this weekend, but football fans will still be able to get their fill with action from Round 3 of the FA Cup.
With several Premiership clubs going head-to-head, there will be no shortage of action.
In addition, exciting young talents from the lower leagues will be looking to prove that it will not be long before they are featured on England's biggest stage.
Here are the players who will shine brightest in the many matches that will be played later this week.


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[Intro: Andre 3000]
Ahhhh.. I stank I can, I stank I can
The funky engine that could
Oooo oooo yosky, wosky, pisky, wisky
All aboard the Stankonia Express
The underground smell road
Everybody's lookin' for an excuse to let loose
What's your locomotive, the Chatta-nigga choo choo?
[Hook: André 3000 & Erykah Badu]
Humble as a mumble in the jungle
Of shouts and screams
That's the way the cracker crumbles
So I guess I've got to re-route my dreams
This Stankonia cut is one of the select few songs where 3 Stacks performs with his baby mama Erykah Badu. It deals with themes like continuing to work hard in the face of adversity, making something of your life, and spreading socially-conscious messages through sensationalized raps.


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Maxine Mesinger
Maxine Mesinger, née Maxine Ethel David (December 19, 1925 - January 19, 2001[1]) was a celebrity gossip columnist of the Houston Chronicle who was active between 1965 and 2000. Her works were published in the "Big City Beat," her social column. She had the nickname "Miss Moonlight".[2] Clifford Pugh of the Houston Chronicle said that she "wrote about big names for half of the 20th century and became a celebrity in her own right".[1] Lisa Gray of the Houston Press said that Mesinger "wrote in the swingin' lingo of '40s showbiz".[3]
She was born in 1925 to Julian "Drake" David and Ella David. She graduated from San Jacinto High School. She took post-secondary education at Texas Woman's University, Indiana University Bloomington, and the University of Houston. In 1944 she married Emil Mesinger. They had two children, Julianne and Jay. Mesinger had a career in television.[2] In the 1950s she hosted two celebrity oriented shows on a television network operated by the University of Houston.[1] In 1964 the Houston Chronicle hired her to be a columnist.[2] For a period she and her family lived at the Shamrock Hotel. She had two children, Jay and Julianne. Her collection of antiques, fine art, mementos, and photographs of Hollywood actors and actresses from the second half of the 20th century was called the "Maxine Mesinger Memorial Museum" by her family.[4]
Mesinger was afflicted by multiple sclerosis.[1] On Friday January 19, 2001, at The Methodist Hospital, Mesinger died from complications of multiple sclerosis,[5] at the age 75.[1] On September 9, 2003, the Maxine Mesinger Multiple Sclerosis Clinic at Baylor College of Medicine and The Methodist Hospital opened.[6]
After her death, her collection of art, mementos, and photographs remained intact. Her husband, Emil, continued living in their house near River Oaks. Emil and his children, now adults, did not figure out the best method to dispose of Mesinger's collection. In June 2013 Emil died and the two children established an auction of the collection to be held on October 26, 2013 at Morton Auctioneers and Appraisers.[4] The Auctioneer for the Mesigner Estate Auction was Houston auctioneer and Vice-President of Morton's Auctioneers and Appraisers, Colette Clift Mayers.[7] The Mesinger Sclerosis Clinic was scheduled to receive a portion of the proceeds.[4]
- ^ a b c d e Pugh, Clifford. "Long-time, well-known society columnist dies" at the Wayback Machine (archived February 15, 2001) (Archive). Houston Chronicle at the Fort Worth Star-Telegram. Friday January 19, 2011. Retrieved on November 20, 2011.
- ^ a b c "Maxine Mesinger Papers, 1965-2001." University of Houston. Retrieved on November 20, 2011.
- ^ Gray, Lisa. "Goodnight, Miss Moonlight." Houston Press. Thursday February 1, 2001. 1. Retrieved on November 20, 2011.
- ^ a b c Feldman, Claudia. "Auction set for Chron columnist Mesinger's mementoes" (Archive). Houston Chronicle. October 8, 2013. Retrieved on October 9, 2013. "In the midst of those glory days, the Mesinger family lived at the old Shamrock Hilton Hotel,[...]"
- ^ "Maxine Mesinger Houston Chronicle 1925-2001" at the Wayback Machine (archived April 5, 2001) (Archive). Houston Chronicle. April 5, 2001. Retrieved on November 20, 2011.
- ^ "Maxine Mesinger Multiple Sclerosis Clinic." The Methodist Hospital. Retrieved on November 20, 2011.
- ^ Feldman, Claudia. "Mesinger treasures sold to the highest bidders" (Archive). Houston Chronicle. October 26, 2013. Retrieved on May 5, 2015.


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Based in the Milwaukee area, C.H. Coakley maintains a proud history of successfully handling literally thousands of companies' relocations.
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Corporate Relocation to 3PL Services: C.H. Coakley is Your Single-Source Solution
C.H. Coakley & Co. offers everything from corporate relocation to 3PL services for a wide range of industries.
We serve:
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From corporate relocation to 3PL services, some of our larger clients have included the Milwaukee County Medical Complex, American Transmission Company, Chicago Records Management and Harley-Davidson Motor Company.
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Based on your project requirements and service needs, C.H. Coakley will assemble the right team to meet and exceed your expectations. We work together with you to coordinate, organize and execute a comprehensive strategy which is convenient, efficient, cost-effective and stress-free. We also make sure to stay in-line with your timeframe and budget requirements.
C.H. Coakley is comprised of 8 total divisions; however the services we provide most often include:
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Whether you're company is relocating across town or across the world, C.H. Coakley has teams of highly skilled specialists who ensure your assets are handled with utmost care and your move is conducted with the highest level of organization and efficiency.
C.H. Coakley's partners with Mayflower Transit, a global leader among commercial moving companies. With fast quoting, real-time shipment tracking, ease of communication and professional drivers, it's no surprise C.H. Coakley Mayflower has become one of the most highly regarded among shipping, transportation and commercial moving companies.
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C.H. Coakley offers certified United Mayflower Containers for your portable storage needs. These portable storage containers can be kept at your location for convenient access.
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C.H. Coakley provides domestic and international 3PL services. Our wide-reaching network of transportation resources gives us a competitive edge on flexibility and global reach.
Tactical routing analytics enables our team of specialists to accurately coordinate 3PL services based on time and budget.
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When trust, reputation and experience matter turn to C.H. Coakley as your 3PL provider.
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Many C.H. Coakley customers use our micrographics services and storage solutions in conjunction with secure off-site data storage, electronic vaulting, temperature-controlled storage and/or data destruction.


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Adobe Flashes Signs Of Optimism In Latest EarningsInvestors are embracing Adobe's move to the cloud
What Was That Strange Streak Of Light In The Bay Area Sky Friday Morning?People across the Bay Area reported seeing a streak of light shoot across the sky Friday around 6 a.m.
The CW Adding 'The Flash' To Fall ScheduleKBCW/The CW is bringing another superhero to the small screen as part of its upcoming offerings...
Flash Flood Warning Issued For Sonoma CountyThe National Weather Service issued a flash flood warning for Sonoma County. The warning is in effect until 7:30 p.m. Residents should not attempt to cross swiftly flowing water.
Adobe Abandons Flash For Mobile Web BrowsersAdobe says it will pull Flash, its software for Web video and software, from the Web browsers of mobile devices. Flash will still work on mobile apps and on computers' Web browsers.
Tech Report: Cookies That Last Forever


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Tokyo sky cruising : Helicopter tour
Enjoy the view of Tokyo from the sky in a helicopter cruise with a special person or friends by charter flight.
Duration: 20 minutes
From $519
per group
Likely to sell out
TokyoSee all 151 tickets & tours
Want to discover all there is to do in Rainbow Bridge, Tokyo? Click here for a full list.


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The National Civil War Museum in Harrisburg will hold the annual Civil War Adventure Day Camp 9 a.m.-3 p.m. Aug. 4-6.
The camp includes hands-on activities, crafts, games, food and music. Limited scholarships are available compliments of the Hershey Company and spots will be filled on a first-come, first-served basis.
This camp will compare the resources of the North and the South, explore social expectations and explain the role of slavery in the war. Campers will get the opportunity to dress in period clothing, experience the life of the soldier and dance and sing to Civil War era music.
Students entering fourth through sixth grades are eligible. Cost is $100. Snacks and materials are provided but campers must bring their own lunch.
Reservations are needed by July 28 by sending an email to firstname.lastname@example.com or by calling 717-260-1861.


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Sunday, November 15, 2015
Wearable Technology-Personal "airbags"
One of my regular "must reads" is Aging In Place Technology Watch. I love reading about all the new cool tech and how companies are innovating to make lives better for us as we age. So catching up on reading emails, I was reading the post on the LeadingAge2015 Annual meeting. The technologies reported in this post were fascinating, but the one that really caught my attention was HipHope. Looking at the website, the best way I can describe the technology is wearable air bags.
The website describes the device. "Hip-Hope™ is a revolutionary active hip protector device, providing unprecedented fall impact absorption effectiveness, combined with highly reliable real-time fall detection capability. Hip-Hope™ unique achievements are a result of "out-of-the-box" design concepts and technological innovations."
According to the website, the device deploys in the blink of the eye, and it looks compact and easily wearable. Check out the video demonstrating it.
November 15, 2015 in Consumer Information, Current Affairs, Health Care/Long Term Care, Other | Permalink | Comments (0)
Monday, November 2, 2015
Arbitration Clauses-They're Everywhere
If you haven't read this yet, this is a must-read. The New York Times did an in-depth series on the use of mandatory arbitration clauses. On October 31, 2015, the Times ran the first in the series: Arbitration Everywhere, Stacking the Deck of Justice. On November 1, 2015, the next story in the series ran: In Arbitration, a 'Privatization of the Justice System'.
I recommend you read them in order. What you learn may be surprising. We have all heard about arbitration clauses in long-term care agreements. You may be surprised to learn the breadth of use of arbitration clauses.
Read the series. And assign it to your students.
November 2, 2015 in Consumer Information, Current Affairs, Other | Permalink | Comments (0)
Monday, August 24, 2015
Call in Program Today with Ken Dychtwald
Today Ken Dychtwald (AgeWave) will appear on NPR/KQED's Forum with Michael Krasny. The call-in program is set from 10-11 pdt. According to the email announcement I received from AgeWave, the program host and Mr. Dychtwald "will be candidly discussing Ken's thoughts and personal feelings about what it means to be an aging expert who just turned 65. For the first time, Ken will publicly reflect on how he is both distressed and motivated by his own aging process and how his books, such as Age Wave, may or may not jibe with what he is now experiencing personally." Listen to the interview here: http://www.kqed.org/radio/listen/.
Can't make the live program? This is the link to where the interview will be archived:
August 24, 2015 in Current Affairs, Other, Webinars | Permalink | Comments (0)
Wednesday, August 12, 2015
Aging America-County by County
The Pew Research Center released a map showing the aging of America by county. Where do the oldest Americans live? provides a map of the U.S. that shows the percentage of a county's population 65 and older. As the website explains, due to the aging of the Boomers and increased longevity,
more counties across America are graying. A new Pew Research Center analysis of the Census Bureau's 2014 population estimates finds that 97% of counties saw an increase in their 65-and-older population since 2010.
On average, a U.S. county's 65-and-older population grew by 12.4% from 2010 to 2014. (Our analysis of population change over time included only counties or county equivalents with a population of 1,000 or more adults ages 65 and older in 2014.)
And yes, Florida is still one of the "grayest" states, with 3 Florida counties ranking in the top 4 of the grayest counties. The report notes as well that some states are getting "younger" with
a tiny share of counties (3%) saw a drop in the 65-and-older demographic since 2010. Oklahoma's small Alfalfa County, on the Kansas border, had the highest rate of decrease in the 65-and-older population, at 9.5%... North Dakota ... had two counties, Williams and Wells, rank among the top five for rate of decrease of adults 65 and older. Three counties experienced no change since 2010... Alaska is the "youngest" state based on its share that is 65 and older (9.4%). Fully 26 of 29 Alaska counties have percentages of people 65 and older that fall below the U.S. average.
August 12, 2015 in Current Affairs, Other, Statistics | Permalink | Comments (0)
Wednesday, August 5, 2015
Tech Innovations Announced in Conjunction With the White House Conference on Aging
I was reading a blog post from Aging in Place Technology Watch which offered a roundup of tech announcements coming out of the 2015 White House Conference on Aging. I was intrigued by the UberAssist project which according to the announcement on Uber's website
Today, Uber will participate in the White House Conference on Aging and discuss Uber's efforts to engage the senior community. At the event, we will announce the launch of a pilot program for community-based senior outreach. In cities across the country, Uber will offer free technology tutorials and free rides at select retirement communities and senior centers. Alongside public and private sector representatives, we hope to further the conversation about the way technology adoption can improve older adults' day-to-day lives.
Uber has some projects going in Florida, for example, in Gainesville, Uber
is working with the City ... to offer on-demand transportation for residents of two senior centers as part of a six month program. Anytime a resident at a participating senior center needs a ride, he or she can request one at an even more affordable rate because of support from the city. Free technology tutorials will be available throughout, so residents of the participating centers can feel comfortable and at ease using Uber. Uber is also piloting a similar senior ride program in partnership with the Town of Miami Lakes.
I also was interested to learn about the announcement from Phillips about the AgingWell Hub which is
a unique new collaborative research and development initiative for open innovation that will examine and share solutions for aging well. The initiative will identify new technologies, products and services, as well as provide thought leadership in collaboration with older adults, caregivers, healthcare systems, payers, policy makers, corporate innovators, entrepreneurs and academia. The AWH will also seek solutions to improve technology adoption among older adults and make aging well a reality for more people, by enabling them to better connect with their communities and healthcare providers.
You can read all of the WHCOA partner press releases and announcements here.
August 5, 2015 in Consumer Information, Current Affairs, Other, Web/Tech | Permalink | Comments (0)
Tuesday, August 4, 2015
Virtual Heartbreak
The New York Times ran a story on July 17, 2015 on how scammers are targeting older individuals on internet dating sites. Swindlers Target Older Women on Dating Websites tells the stories of several elders who ended up sending significant sums of money to scammers who had developed virtual relationships with these elders. This high-tech version of the "romance con" has resulted in the legislature in at least one state, Vermont, to consider "pass[ing] a law requiring online dating sites to notify members quickly when there is suspicious activity on their accounts or when another member has been barred on suspicion of financial fraud." As well, the story explains, the proliferation of the virtual version of the romance con was the impetus for action from AARP.
Despite warnings, the digital version of the romance con is now sufficiently widespread that AARP's Fraud Watch Network in June urged online dating sites to institute more safeguards to protect against such fraud. The safeguards it suggests include using computer algorithms to detect suspicious language patterns, searching for fake profiles, alerting members who have been in contact with someone using a fake profile and providing more education so members are aware of romance cons.
The AARP network recommends that from the beginning, dating site members use Google's "search by image" to see if the suitor's picture appears on other sites with different names. If an email from "a potential suitor seems suspicious, cut and paste it into Google and see if the words pop up on any romance scam sites," the network advised.
On AARP's site, individuals can learn more about these digital romance cons, sign an on-line petition to dating sites to adopt safety measures, and learn 10 tips on how to spot a romance scammer and 5 tips to protect oneself from this "virtual heartbreak".
August 4, 2015 in Consumer Information, Current Affairs, Other, Web/Tech | Permalink | Comments (0)
Tuesday, July 28, 2015
Pop Culture in Your Classroom?
Professor Cynthia Bond at John Marshall Law is doing a survey on how law profs use pop culture in their classrooms. Here is her email providing more info and requesting responses to her survey:
Greetings Law Teacher Colleagues:
I am working on an article this summer on uses of popular culture in the law school classroom. I am defining popular culture broadly to include mass culture texts like movies, TV shows, popular music, images which circulate on the internet, etc, and also any current events that you may reference in the classroom which are not purely legal in nature (i.e. not simply a recent court decision).
To support this article, I am doing a rather unscientific survey to get a sense of what law professors are doing in this area. If you are a law professor and you use popular culture in your class, I would be most grateful if you could answer this quick, anonymous survey I have put together:
Thanks in advance for your time and have a wonderful rest of summer!
Cynthia Bond
The John Marshall Law School
Chicago, IL
July 28, 2015 in Current Affairs, Film, Music, Other, Television | Permalink | Comments (0)
Saturday, June 13, 2015
Forty-nine years ago...
The New York Times' "On this Day" squib reminded us today:
"On June 13, 1966, the Supreme Court issued its landmark Miranda vs. Arizona decision, ruling that criminal suspects must be informed of their constitutional rights prior to questioning by police."
That triggered memories, as the day the landmark decision first became known in Arizona, the father of one of my friends offered everyone in the neighborhood a glass of champagne, even us kids. At the time I did not fully appreciate the reason. It was only years later that I put it together that the celebrant was John P. Flynn, the lawyer who successfully argued the Miranda case before the U.S. Supreme Court.
Even more years later, in the 2000 Supreme Court decision of Dickerson v. U.S., another man from that same Phoenix, Arizona neighborhood would confirm the importance of "Miranda warnings" as an accepted mainstay of protection for individuals suspected of crimes. Chief Justice William H. Rehnquist did not share the legal or political philosophies that generated the original ruling, but he could be persuaded to respect the role of stare decisis. I have often been bemused by the fact that John Flynn, a bold advocate and life-long Democrat, had once celebrated his biggest victory with the children of the neighborhood, including the children of a future Supreme Court Justice, well known for his conservatism. Phoenix, especially the legal community, was a very small town in those days.
My trip down memory lane took me to a colorful account of John P. Flynn's life. It is the story of a creative and talented lawyer, from an era much more tolerant of personal flaws. Read "Remembering John Flynn" by his one-time law partner Tom Galbraith.
June 13, 2015 in Crimes, Ethical Issues, Federal Cases, Other | Permalink | Comments (0)
Wednesday, June 10, 2015
White House Conference on Aging July 13, 2015
Mark your calendars. The date for the WHCOA has been set for July 13, 2015. The event is going to be webcast live. Folks are encouraged to watch it and even tweet questions for the panelists at the conference. For more ideas and information, click here.
June 10, 2015 in Current Affairs, Health Care/Long Term Care, Housing, Other, Programs/CLEs, Retirement, Webinars | Permalink | Comments (0)
Monday, June 8, 2015
Living a Longer, Fulfilling Life?
The Wall Street Journal ran an interesting article on May 31 about longevity and how to have a fulfilling life with those extra years of living. How to Make the Most of Longer Lives focuses not just on planning financially for living longer, but questions what to do with those added years to be sure one has a meaningful life. The author suggests "[w]e need to marshal imagination and ingenuity to devise new strategies for enhancing the whole range of experiences in later life, including education, faith, housing, work, finance and community" and then offers six suggestions to increase the quality of life: (1) give a new name to this period of life; (2) smooth the way to transition into this part of life (or as the author explains it retirement and then "un-retirement" is "a do-it-yourself process. It's time to help make this post-midlife passage more efficient and suited to preparing individuals emotionally and spiritually for what lies ahead."); (3) education specifically for the second half of life (4) financial security; (5) promote multi-generational housing; (6) create a model where inventors brainstorm new ideas for this part of life.
The author concludes with reference to the upcoming White House Conference on Aging and the challenges that await all of us with aging.
June 8, 2015 in Current Affairs, Other, Retirement | Permalink | Comments (0)
Tuesday, May 26, 2015
How Much Money Will You Have at the End of Your Life?
The Employee Benefits Research Institute (EBRI) published a note in April, 2015 that looked at the question of how much money people have at the end of their lives. A Look At the End-of-Life Financial Situation in America. Here is what the study examined
This report takes a comprehensive look at the financial situation of older Americans at the end of their lives. In particular, it documents the percentage of households with a member who recently died with very few assets (total assets as well as non-housing assets). It also documents income, debt, home-ownership rates, net home equity and the share of their income coming from Social Security benefits for those households.
This report is useful as part of the work by EBRI in looking at retirement security and whether people will have sufficient funds to last the rest of their lives. Here are some bullets from the conclusion:
- For those who died at ages 85 or above, 20.6 percent had no non-housing assets and 12.2 percent had no assets left.
- Among singles who died at or above age 85, 24.6 percent had no non-housing assets left and 16.7 percent had no assets left.
- Those who died at earlier ages were generally worse off financially: 29.8 percent of households that lost a member between ages 50 and 64 had no assets left.
- People who died earlier also had significantly lower household income than households with all surviving members.
- Among singles who died at ages 85 or above, 9.1 percent had outstanding debt (other than mortgage debt) and the average debt amount was $6,368.
- The average net equity left in their primary residence for those who died at ages 85 or above was $141,147 and $83,471 for couple and single households, respectively.
May 26, 2015 in Other, Retirement | Permalink | Comments (0) | TrackBack (0)
Friday, April 24, 2015
Got an Idea? Maybe You Are an Inventor!
Are you an inventor? Ever have a good idea for an invention? There is a renaissance of sorts in American ingenuity with an increasing number of older Americans becoming inventors. The NY Times ran a story about older inventors on April 17, 2015. More Older Adults Are Becoming Inventors notes this renaissance
Whether as volunteers or for profit, older inventors ... are riding a rising tide of American innovation. They are teaming up, joining inventors clubs and getting their products into the marketplace. And older inventors bring valuable skills to their work, many experts say, like worldly wisdom and problem-solving abilities that can give them an advantage over younger inventors.
According to the article, the Baby Boomers are at least part of the catalysts for this surge of older inventors, as the boomers look for products to assist them as they get older. According to one expert quoted in the article, older inventors may have an edge over younger ones, since "[a]n aging brain can see patterns better." Before you get out the proverbial drawing board, the article notes that inventions don't necessarily lead to wealth with less than 5% of inventions making money, not to mention the prototype and startup costs
April 24, 2015 in Consumer Information, Current Affairs, Other | Permalink | Comments (0) | TrackBack (0)
Wednesday, April 22, 2015
Fundamentals of SNT Administration webinar-it's not too late to register
Stetson College of Law and the Center for Excellence in Elder Law at Stetson Law (full disclosure, I'm hosting this webinar) is offering the annual Fundamentals webinar on Friday April 24, 2015 from 1-5 p.m.. This half-day webinar features presentations by Stu Zimring, Mary Alice Jackson and Robert Fleming. More information, the schedule and registration information are available here.
April 22, 2015 in Estates and Trusts, Other, Programs/CLEs | Permalink | Comments (0) | TrackBack (0)
Tuesday, March 17, 2015
Promises of Confidentiality in Academic Research? Potential Lessons from The Belfast Project
Today is St. Patrick's Day, celebrated with greater fervor in many U.S. communities than it is in Ireland. Indeed, as I learned during my 2010 sabbatical in Northern Ireland, while Belfast is home to a variety of dramatic "historical" parades and holidays, events on St. Patrick's Day are low key and mostly for children.
In the March 16 issue of The New Yorker magazine, writer (and Yale-educated lawyer) Patrick Radden Keefe digs into the history of Northern Ireland, looking at the late stages of the Troubles. He examines possible roles played by Gerry Adams as an acknowledged leader of political party Sinn Fein versus his long-denied authority for certain violent actions of the IRA.
Keefe provides a comprehensive analysis of the events before and after the Good Friday Agreement of 1998, offering details that are devastating if true about how violence was often at its most problematic when perpetrated within the ranks of extreme republican and loyalist factions. Central to the history is the lingering question of who was responsible for the December 1972 abduction and execution of Jean McConville, the widowed mother of 10 children, suspected of informing against the IRA.
In the article, Gerry Adams comes across as determined to be both charismatic and enigmatic, as hero and anti-hero, as deeply devoted to a "United Ireland," while also oddly enamored with trivial self-promotion. I came away from the article thinking it was a good reminder of how dangerous it can be -- in any country -- to believe absolutely in any single leader.
The article also presents ethical questions associated with efforts to document the Troubles through oral histories recorded under the auspices of Boston College:
March 17, 2015 in Books, Ethical Issues, International, Other | Permalink | Comments (0) | TrackBack (0)
Friday, February 27, 2015
Indiana Law Review Symposium: State Governments & Aging Populations
Check out Volume 48, Issue 1 of the Indiana Law Review which contains articles from the 2013 Program on Law & State Government Fellowship Symposium: State Governments Face the Realities of Aging Populations. Three articles are included from the symposium, all of which are available on-line. The articles include Introduction: Governing Choices in the Face of a Generational Storm, Aging Populations and Physician Aid in Dying: The Evolution of State Government Policy, and What the Future of Aging Means to All of Us: An Era of Possibilities.
February 27, 2015 in Advance Directives/End-of-Life, Health Care/Long Term Care, Housing, Other, Programs/CLEs | Permalink | Comments (0) | TrackBack (0)
Friday, February 6, 2015
Another Movie for Our List
I recently watched the movie, The Judge, starring Robert Downey, Jr. and Robert Duvall, among others. The premise of the movie is interesting and there's even a good thread about ethics (especially Rule 1.1) running through the movie. What caught my eye toward the end of the movie is (spoiler alert) the use of compassionate release. Although we may cover this in our classes, I don't know that I've seen that crop up in movies. So, I'm thinking of adding this movie to my list for my elder law class. Any movies you think should be on the list?
February 6, 2015 in Crimes, Other, Television | Permalink | Comments (2) | TrackBack (0)
Wednesday, January 14, 2015
Follow the happenings with the White House Conference on Aging 2015
Directly from the White House:
The first White House Conference on Aging (WHCoA) was held in 1961, with subsequent conferences in 1971, 1981, 1995, and 2005. These conferences have been viewed as catalysts for development of aging policy over the past 50 years. The conferences generated ideas and momentum prompting the establishment of and/or key improvements in many of the programs that represent America's commitment to older Americans including: Medicare, Medicaid, Social Security, and the Older Americans Act.
The 2015 White House Conference on Aging
2015 marks the 50th anniversary of Medicare, Medicaid, and the Older Americans Act, as well as the 80th anniversary of Social Security. The 2015 White House Conference on Aging is an opportunity to recognize the importance of these key programs as well as to look ahead to the issues that will help shape the landscape for older Americans for the next decade.
In the past, conference processes were determined by statute with the form and structure directed by Congress through legislation authorizing the Older Americans Act. To date, Congress has not reauthorized the Older Americans Act, and the pending bill does not include a statutory requirement or framework for the 2015 conference.
However, the White House is committed to hosting a White House Conference on Aging in 2015 and intends to seek broad public engagement and work closely with stakeholders in developing the conference. We also plan to use web tools and social media to encourage as many older Americans as possible to participate. We are engaging with stakeholders and members of the public about the issues and ideas most important to older individuals, their caregivers, and families. We also encourage people to submit their ideas directly through the Get Involved section on this website.
January 14, 2015 in Consumer Information, Federal Statutes/Regulations, Other, Programs/CLEs, Web/Tech, Webinars, Weblogs | Permalink | TrackBack (0)
Wednesday, December 3, 2014
Canada: New online program aims to help reduce financial abuse of seniors through education and awareness
Launch of Financial Abuse of Older Adults: Recognize, Review and Respond program marks end of Financial Literacy Month
In honour of November being Financial Literacy Month, Credit Union Central of Canada (CUCC) has partnered with Credit Union Central of Manitoba (CUCM) and Prevent Elder Abuse Manitoba (PEAM) – in collaboration with the Financial Consumer Agency of Canada – to launch a new online course: Financial Abuse of Older Adults: Recognize, Review and Respond. The purpose of this course is to help educate credit union staff about financial elder abuse and provide them with key information, including: how to identify incidences of elder abuse; how to mitigate the risks; community resources available; as well as the legal and ethical responsibilities of both the financial institution and the senior involved. Upon completion of the course, credit union employees will have the opportunity to share their knowledge with members of the community – especially with Canadian seniors –, to help them understand more about elder abuse and how to prevent it happening to them. Minister of State (Seniors), the Honourable Alice Wong; Minister of Healthy Living and Seniors (Manitoba), the Honourable Deanne Crothers; Lawrence Toet, MP (Elmwood-Transcona); Jane Rooney, Financial Literacy Leader; Martha Durdin, President and CEO of Credit Union Central of Canada, and Ted Richert, Vice President, Credit Union Central of Manitoba will make remarks. The program was written and developed by Tamlo International Inc. and will be distributed exclusively by CUSOURCE Credit Union Knowledge Network, a wholly owned subsidiary of Credit Union Central of Canada that provides learning and development solutions to the Canadian credit union system.
Source: Canada News Wire
December 3, 2014 in Elder Abuse/Guardianship/Conservatorship, International, Other, Programs/CLEs | Permalink | TrackBack (0)
Sunday, November 2, 2014
Laughter is Great Medicine-Even When Talking About Zombies
Start your week with a laugh, or at least a smile.
One of the many blogs I read, GeriPal, ran an excellent parody for Halloween that had me howling....with laughter at the author's cleverness. Addressing Unmet Palliative and Geriatric Needs of Zombies is a hysterical must-read. The title gives you an excellent preview. And don't ignore the links in the article to the other sources, especially the one regarding the speed with which the Grim Reaper walks (at least the section on strengths and limitations).
November 2, 2014 in Advance Directives/End-of-Life, Cognitive Impairment, Health Care/Long Term Care, Other | Permalink | Comments (0) | TrackBack (0)
Wednesday, October 1, 2014
On the Escalator of An Aging Society?
A few days ago I blogged about an article in The Atlantic explaining one person's thinking of 75 being his optimal "old age". In that same issue of The Atlantic is another article--about longevity and 100 year olds--what it will mean for society as more of us reach that age. What Happens When We All Live to 100? was published on September 17, 2014.
The article starts with a history of sorts of life expectancies from human origins and notes that
Viewed globally, the lengthening of life spans seems independent of any single, specific event. It didn't accelerate much as antibiotics and vaccines became common. Nor did it retreat much during wars or disease outbreaks. A graph of global life expectancy over time looks like an escalator rising smoothly. The trend holds, in most years, in individual nations rich and poor; the whole world is riding the escalator.
Projections of ever-longer life spans assume no incredible medical discoveries—rather, that the escalator ride simply continues. If anti-aging drugs or genetic therapies are found, the climb could accelerate. Centenarians may become the norm, rather than rarities who generate a headline in the local newspaper.
The article then moves to a discussion of those institutions intentionally working on increasing life spans, the Buck Institute, the U of Michigan, the U of Texas, UC-San Francisco, and the Mayo Clinic for example. Long-term readers of this blog may also remember a post about CALICO (Google's "spin-off called the California Life Company (known as Calico) to specialize in longevity research."). The article has a fascinating section about the research being done, including some interesting consideration of other life forms that excel in longevity (worm genes, anyone?).
I particular enjoyed reading the quote of one of the leaders in the field in describing the nascent nature of the research. "'[M]edically, we do not know what 'age' is. The sole means to determine age is by asking for date of birth. That's what a basic level this research still is at.'" There seems to be some debate amongst the experts about whether life expectancy will continue to rise at the steady escalator-smooth rate as in years past. The article also mentions some of the theories advanced over time on increasingly longevity: vitamins, low calorie diets, education, exercise, etc.
One section of the article bears significant possibilities for class discussion, the political implications of an older society.
Society is dominated by the old—old political leaders, old judges. With each passing year, as longevity increases, the intergenerational imbalance worsens. The old demand benefits for which the young must pay, while people in their 20s become disenchanted, feeling that the deck is stacked against them. National debt increases at an alarming rate. Innovation and fresh thinking disappear as energies are devoted to defending current pie-slicing arrangements.
The author reveals this is a description of what is actually occurring in Japan. Consider as the author does, what increased longevity may also do to the judicial branch--especially the Supreme Court with lifetime appointments.
This article may be viewed as a bit of a wake-up alarm, although I suspect many of the folks in the US will just hit the snooze button
People's retirement savings simply must increase, though this means financial self-discipline, which Americans are not known for. Beyond that, most individuals will likely need to take a new view of what retirement should be: not a toggle switch—no work at all, after years of full-time labor—but a continuum on which a person gradually downshifts to half-time, then to working now and then. Let's call it the "retirement track" rather than retirement: a phase of continuing to earn and save as full-time work winds down.
Widespread adoption of a retirement track would necessitate changes in public policy and in employers' attitudes. Banks don't think in terms of smallish loans to help a person in the second half of life start a home-based business, but such lending might be vital to a graying population. Many employers are required to continue offering health insurance to those who stay on the job past 65, even though they are eligible for Medicare. Employers' premiums for these workers are much higher than for young workers, which means employers may have a logical reason to want anyone past 65 off the payroll. Ending this requirement would make seniors more attractive to employers.
Back to the reasons for increasing longevity. One in the list above, education, seems to have a solid correlation and maybe not as obvious as other reasons that come to mind (vaccines, antibiotics, improved health care, public services, etc.). The author considers the role of education in longevity and examining budget cuts by states, suggests
Many of the social developments that improve longevity—better sanitation, less pollution, improved emergency rooms—are provided to all on an egalitarian basis. But today's public high schools are dreadful in many inner-city areas, and broadly across states ... Legislatures are cutting support for public universities, while the cost of higher education rises faster than inflation. These issues are discussed in terms of fairness; perhaps health should be added as a concern in the debate. If education is the trump card of longevity, the top quintile may pull away from the rest
The last section of the article hypothesizes on the impact of an aging society if the escalator continues its ascent, achieving perhaps a "grey utopia" of sorts. The article is well worth reading, but it makes me think about how society values, or devalues, aging. Is getting old a challenge or disease to be conquered? For example, the author writes, "[i]f the passage of time itself turns out to be the challenge, interdisciplinary study of aging might overtake the disease-by-disease approach. As recently as a generation ago, it would have seemed totally crazy to suppose that aging could be "cured." Now curing aging seems, well, only somewhat crazy." Read this article and have your students read it, too.
October 1, 2014 in Current Affairs, Dementia/Alzheimer's, Health Care/Long Term Care, Other, Science, Statistics | Permalink | Comments (0) | TrackBack (0)


text:
DST it is pleased to announce that it has been appointed the authorised reseller of the RetailNext solutions in Australia and New Zealand. RetailNext is the market leader in Big Data solutions for bricks-and-mortar challenges faced by retailers around the globe.
The essential information Australian retailers have been lacking
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Why DST it & DST retail
RetailNext acknowledged that the combination of experience and skills provided by DST it and DST retail provides a unique opportunity for a successful value add partnership which will cover the sales, installation, implementation, analytical assistance and ongoing support for the RetailNext solutions.


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text:
KC is approved to conduct lessons through Wyzant Online. Wyzant Online allows students and tutors to work remotely via video, audio, and collaborative whiteboard tools. For more information about how online tutoring works, check out Wyzant Online.
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Georgia Institute of Technology (Chemistry Biochem.)
The University of Chicago Chicago, IL (PhD)
I have a Ph.D. in biochemistry from The University of Chicago. My previous research work was in biochemistry, structural biochemistry, and analytical chemistry, so I also have a thorough knowledge of a variety of chemistry topics. Due to this, I can offer tutoring services in all areas of chemistry, including general, organic, analytical, electrochemistry, and biochemistry. I will gladly assist undergraduate and high school students in the world of chemistry to help improve grades or prepare for the AP Chemistry examination.
My previous instructional experiences include the tutoring of high school students in general and AP chemistry, tutoring undergraduate and professional students in biochemistry and organic chemistry, and helping undergraduate students initiate their research projects in chemistry and biochemistry laboratories. My main goals are to help students grasp the basic theories covered in class, improve study techniques to prepare for exams, and to increase confidence in problem solving by introducing strategies on how to understand and approach questions. If you have any questions about topics I can cover or my availability, please feel free to contact me, and I will assess whether or not I can assist you in your endeavors in the world of science. I have a Ph.D. in biochemistry from The University of Chicago. My previous research work was in biochemistry, structural biochemistry, and analytical chemistry, so I also have a thorough knowledge of a variety of
KC is approved to conduct lessons through Wyzant Online. Wyzant Online allows students and tutors to work remotely via video, audio, and collaborative whiteboard tools. For more information about how online tutoring works, check out Wyzant Online.
If you're interested in online lessons, message KC to get started.
KC is a really great tutor. He knows his material and he breaks it down to easily understand it. He also makes outlines and highlights important information for you to take home with you so you can study on your own which is really helpful. He is professional, on time, and very friendly. I will be meeting with him again!
KC has been wonderful. He has explained things to both my brother and I in a way that we can really understand and grasp the material. He's always been either early or on time to our sessions, and he's very polite. He's awesome!
Over the last 10 years I have had several tutors for various subjects, including chemistry, and I find that KC is by far the most knowledgeable, thorough, and prepared tutor I have met. His professionalism and ability to simplify complex chemistry theories into plain English is remarkable!
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I have helped teach an introductory biochemistry topics course for undergraduate students. My biochemistry course work includes biochemistry I and II, undergraduate and graduate biophysics, graduate biochemistry, and also laboratory courses.
I can cover a wide variety of the general chemistry course topics covered in typical high school and undergraduate courses. These include nomenclature, terminology, thermodynamics, acid-base reactions, and kinetics. Please feel free to contact me with questions if you would like more information on my background or approach to certain topics or problem types.
Successful organic chemistry mastery starts with memorizing the details of each synthesis step and solving problems by applying this knowledge to complete a detailed synthesis procedure. I can assist in learning either or both of these requirements for undergraduate and professional Organic Chemistry I and II courses.
As a chemistry student, I took Organic Chemistry I & II in addition to their corresponding laboratory courses. I also opted to sit for the American Chemical Society examination, on which I received high marks. I also took an international organic chemistry course in Hong Kong, which covered more advanced syntheses. My instructional experience with this topic has mostly been assisting students prepare for their medical school examinations, but I am highly interested in helping other students in their examinations or assignments for organic chemistry courses.
Please feel free to contact me if you're stuck with a problem, would like extra help throughout a course, or would like a quick review for an exam!
PhD To Assist With High School and College Chemistry Topics