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Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, the smooth muscle cells in blood vessels demonstrate a high degree of plasticity, so they can specialise or multiply as required, even repairing damage to the vessel wall. This vascular remodelling is evidently precisely regulated. Disruptions are extremely significant in conditions such as atherosclerosis or high blood pressure. At the Max Planck Institute for Heart and Lung Research in Bad Nauheim, scientists conducting research on genetically modified mice have discovered how external signals regulate vascular remodelling at cell level. This has created an entirely new understanding of regulation, which could pave the way for new approaches in the prevention and treatment of atherosclerosis and other vascular diseases.
The walls of blood vessels consist of smooth muscle cells, elastic fibres, and endothelial cells, which line the interior surface of the vessel. The vessels change their permeability and contractility as required. If a blood vessel is damaged, existing smooth muscle cells can give rise to new specialised muscle cells to repair it. However, in the case of a vascular problem, this necessary and useful cell plasticity can have negative consequences. For example, if a coronary blood vessel is opened up with dilatation and stents via a catheter, muscle cell growth may cause it to narrow once again. In the common condition atherosclerosis or vascular calcification, too, remodelling processes lead to formation of the dreaded plaque. All these processes are regulated by hormones or neurotransmitters, some of which are released by cells and nerves in the vessel wall. Most of these vasoactive messengers work by binding to receptors, which in turn, once activated, bind to what are known as G proteins. These are situated on the inside of the cell membrane and relay the signal from there into the cell interior.
"There are two different families of G proteins which play a crucial role in vascular remodelling. They are called Gq/G11 and G12/G13 after their protein components," explains Max Planck scientist Stefan Offermanns, who has been researching these proteins and their molecular signalling pathways for several years now. In the latest study on genetically modified mice, the team was able to demonstrate for the first time how, in a living animal, these two signalling pathways are regulated by messengers. "Contrary to expectations, the two G protein-mediated signalling pathways antagonistically regulate the plasticity of smooth muscle cells," says Offermanns, summarising the findings. This is surprising in that these signalling pathways act together in other contexts: stimuli that promote vessel contraction and thus increase blood pressure activate both signalling pathways in parallel.
In order to investigate the signalling pathways and their regulation, Till Althoff, who headed the study, examined mice whose genes for the various G proteins he had specifically deactivated. Thus the researcher was able to show, for example, that in a mouse suffering from atherosclerosis and missing G12/G13 in the smooth muscle cells, these cells begin to grow excessively – the result was a considerably thickened vessel wall. By contrast, animals lacking a Gq/G11 protein were protected against this thickening of the cell wall.
"We see here clearly that in vascular remodelling the two signalling pathways work as antagonists," Offermanns explains. Which is only sensible, as it is the only way a system can balance cell growth and regression. In further tests, the scientists also demonstrated the steps required for the two pathways to achieve their objective and stimulate the genes in the cell interior responsible for generating specialised cells or for cell growth.
"Our results really do reveal a completely new picture of the regulation of vascular remodelling, also in pathological processes," says Offermanns. The researchers are therefore hopeful that new pharmacological approaches can be developed. Offermanns can well imagine, for example, that drugs could be used to modulate plasticity in cases of vascular diseases like atherosclerosis or after cardiological interventions. Now that the target structures in both signalling pathways have been identified, new possibilities are opening up. For instance, the pathway that promotes growth could be blocked and the stabilising pathway activated in order to slow down the remodelling process. "In animal models we are already investigating new therapeutic approaches to preventing atherosclerosis and suppressing cell growth in damaged vessels," reports Offermanns.
Till F. Althoff, Julián Albarrán Juárez, Kerstin Troidl, Cong Tang, Shengpeng Wang, Angela Wirth, Mikito Takefuji, Nina Wettschureck, Stefan Offermanns Procontractile G protein-mediated signalling pathways antagonistically regulate smooth muscle differentiation in vascular remodelling. J. Exp. Med. 2012, published online 5 November 2012 DOI: 10.1084/jem.20120350
Max-Planck-Gesellschaft: http://www.mpg.de
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
Free-living songbirds show increased stress hormone levels when nesting under white street lights. But different light spectra may have different physiological effects as this study finds, suggesting that using street lights with specific colour spectra may mitigate effects of light pollution on wildlife
Scientists identify the condition aphantasia, in which people cannot create images in their head
The dust in our homes contains an average of 9,000 different types of fungi and bacteria, a study suggests.
A mosquito can bear up to 23 times its total body weight on each leg, which is crucial for landing on water – the insect's secret is way it stands
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The gloomy octopuses crowded at Jervis Bay, Australia, appear to spit and throw debris such as shell at each other in what could be an intentional use of weapons
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The blind, hairless babies born recently at Washington D.C.'s National Zoo are completely dependent on their mothers—who can sometimes accidentally crush them.
The poop-hoarding insects have an amazingly advanced internal GPS that allows them to navigate by day or night.


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Lately, my webserver provider sent me a message that the order for a year is about to end and that I have to pay for the next year. The Chinese Checkers website on that webserver has been holding just the logo for the whole year. The company of another webserver where I keep this blog, sent me a coupon of 75 € for advertising at Google Adwords. I have an ad, but still no project to advertise. I won't promote my personal blog, will I!? So I have lots of encouragement and motivators, just the time is what I am lack of…
Anyway my creative work doesn't stand still. I learned the basics of Gimp. Whenever I find some free hours among the sessions my work and spare time, I sit down and glue the graphical design together.
I changed the typeface of the logo. It's much more lively and playful now. The Asian motives of the letters fit with the Manga-styled face of the star better that the old bitten typeface.
The website design will be of a space theme. At the moment there are just stars pasted all around. But probably later I will also add satellites, rockets, and even some absurd objects, let's say, a wooden chair flying in the space. I am still thinking how to layout the textual elements like chats, titles, descriptions, collected points, etc. so that they fit in the main design. It's also not clear how to layout the blog and forum as I don't have experience in creating webdesign, but still I want something unique.
All the planets will be different. At the moment I am only drawing the planets of Berlin and Vilnius. WTF? Since when Vilnius has been a planet!? As I've written in the first part, planets will uncover the identity of different capitals of Europe. That's why I was asking for public opinion what things symbolize Vilnius for Lithuanians.
For liveliness each player will be represented by an avatar of the same color which marbles he's using in the Chinese Checkers. I wanted to have single-colored unisex-styled dress. I was thinking about some overalls or cloaks.. Fortunatelly, Viktorija was doing her diploma about cloths which were sexless enough, futuristic, and original. The best part here is that she agreed that those textile designs will be used in my game and sent me the photos and sketches.
I am moving forward in turtle steps. Maybe I'll finish in, let's say, 10 years. It would be better to do that sooner, because I decided to find a girlfriend when I finish this project… As I was jealous of the relations of two couples visiting me recently.


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Discussion in 'Boiler Forum' started by driger, Jun 15, 2014.
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Well, I sure was wrong about the way the stock would react yesterday. That said, I will be adding shares over the coming couple months.
HTCH is down because Hutch mgmnt made confusing and contradictory remarks about the number of ships it will take for profitability and when they will get there. It also seems as if that number has crept a little higher than we were lead to believe from previous ccs. I think they are being more cautious in light of the manufacturing/assy/operation snafus they had in the just reported quarter. They did themselves no favors by not giving us ANY details on what all happened. I understand the need for secrecy in this cut-throat competitive incestuous industry but, give me a break, say something so we know you actually have a grasp on things.
The good news was the status of quals, some of the programs ramping, the expectation of 25%+ market share a year from now, and the words "modestly profitable" coming from CEO lips. But what the f does modestly mean? More confusion for us. So typical of the drive industry, plays right into the hands of the hedgies and flippers and shorts and traders.
My hope is that as they enter the Oct 1 FY, they give firm guidance on ships, revenue, and EPS.
Mayne they are planning insider buys. Hope I can trust Richard Penn. Seems shady to me.
htch in death spiral.....poor management....always making promises they can't keep...
HTCH is dead man walking!
WE saw this bounce as a great opportunity to increase OUR short position!
WE were right!
You buffoons were all wrong!
WE will drive this DOWN, and investors will LOSE!
And now, get the HELL OUT OF HERE!
Sentiment: Strong Sell
I agree about the number creeping higher. Maybe I misunderstood, but I thought just a quarter or so back they were saying 108 M was breakeven. Now 130M is moderately profitable. Hard to get a good read on just what they are saying.
108m was cash flow breakeven. 125m was GAAP profit breakeven.
Sentiment: Strong Buy
Well said, I totally agree the cc was a mess with that said I still think htch will get its day.I was hoping it wouldn't take so long, but it will be worth the wait.at least now they are mentioning the word profit, if they keep ramping up Thailand one of these quarters they are really going to surprise us with a positive earnings report and a great cc.I still believe in the turnaround it is just taking a little longer then anyone expected. I believe management is being honest with us and I am confident they will prevail. The way wdc and stx keep doing so well , it has to help htch soon.glta
What "doing well" at STX & WDC translates into good for HTCH? Unit shipments are down at both. Part of their improved numbers is about leaning on a supply chain that is headed to more and more consolidation. In fact, there are rumors that one or the other of the HDD guys have hired a leading consultancy to define a strategic supplier consolidation. Hutchinson volumes trails competition by a factor of 2. Magnecomp shipped 190m units and about the same , for NHK. So are you thinking DSA transition will save the day? 70% of Magnecomp's shipments in CQ2 were DSA while they were just north of 40% of NHK's output in the same Q. HTCH is the third man out with blindingly lower volumes. Look, I love to be a bull. I love to find turn-around stories, and momentum stories. But there simply isn't one here. HTCH is heading towards an asset sale unless their BOD gets serious about M&A ASAP.
Sentiment: Strong Sell


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City of Angels
... we had exhausted all of the minimal queuing options.
We decided to go to the Simpson's ride, which had the least queuing time. Unfortunately for us, it went up from 35 minutes to 55 minutes just as we arrived. D'oh! Still, this had the shortest queue so we went for it. We were entertained by watching clips of Krusty the Klown being shown on all the screens, so it wasn't a bad queue experience. The ride itself was in a simulator, ...
Hollywood walk of fame
After the red carpet party last night, we celebrated our last full day in LA by catching two metros, a shuttle and subway to Hollywood! We did the walk of fame and more shopping! It is safe to say, we are all exhausted and ready to come home but we have had an ...
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We continued to snake through LA and went past Farmers Market, CBS studios and the school where the Red Hot Chilli Peppers went, as well as Slash from Guns N Roses.
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... place doesn't have is a bath! Jamesy wet my shorts completely while doing this just as I told him to "point it down" but it was too late! Anyway we just laughed about it as what else can you do! They went down well and we watched some telly before heading ourselves.
Highlight of the day: seeing the walk of fame, footprints and handprints on the road - and the Hollywood sign woohoo!
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List Of Mythical Objects Swords
A selection of articles related to list of mythical objects swords.
Original articles from our library related to the List Of Mythical Objects Swords. See Table of Contents for further available material (downloadable resources) on List Of Mythical Objects Swords.
- Sensible Ideas: The Knowledge Behind the Perception
- Do objects exist independently of consciousness? If so, what is the nature of these objects? These questions shall be investigated through the conflicting philosophies of John Locke and George Berkeley. Preliminary Quotations from Locke and Berkeley: Primary...
Religion & Philosophy >> Philosophy
- The Suit of Swords: Tarot Card Meanings
- ACE OF SWORDS Meaning: Clarity of mind, great determination. Conquest. Victory without doubt. Reversed: Tyranny, embarrassment, hindrance, obstacle, self-destruction. 2 OF SWORDS - Peace Meaning: Balanced force. Concord. Solving differences of opinion....
Tarot Cards >> The Minor Arcana
- The Ace of Swords: Seizing the Power of Discernment
- "For the word of God is quick and powerful and sharper than any two edged sword, piercing even to the dividing asunder of soul and spirit and of joints and marrow, and is a discerner of the thoughts and intents of the heart." Hebrews 4:12 KJV I have...
Tarot Cards >> The Minor Arcana
- The Meaning of the Tarot Suit of Swords
- The tarot suit of swords is also known as the suit of blades or spades, depending on the deck. Swords represent the element air. They represent your mental, rational, logical functions, also communication and thought. Swords are indicative of a struggle or...
Tarot Cards >> The Minor Arcana
- Egyptian Amulets
- Amulets are magic objects which are carried on the person. The Egyptian words that refer to these objects are "sa" and "mkt" which are used for protective objects alone and "wedjet" which is used to refer to talisman as well....
History & Anthropology >> Egyptian
- Confessions of a TNT Reiki Master
- Last October I began to take Reiki classes. It came on the heels of an energy healing class I had taken that summer at the request of my friend Henry. At the time I had no intention on becoming a healer. Henry, my best friend and soul brother, lives along...
Body Mysteries >> Reiki
- Hyperspace Reality
- Despite the fact that the 'new' physics, a godchild of the Einsteinian revolution has taught us that the Universe we perceive is a mere shadow of a vastly more unpredictable one, most of us still view the world in a distinctly materialistic way. A world where...
Modern Science >> New Physics
List Of Mythical Objects Swords is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, List Of Mythical Objects Swords books and related discussion.
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- George Washington's corpse was argued over, fought over, and at one point the object of theft. Curiously, all the .... While Washington the myth was ascending to heaven, Washington the corpse was not faring so well.
- Middle Israel: The children's crusade
- Never mind that an object the size of a human is too small to be seen from that distance; where was this angel when the Crusaders later surrendered Jerusalem to Saladin? Where was he another 25 years on, when that entire Holy War project had collapsed, ...
- Achilles is brutal, vain, pitiless – and a true hero
- I also like to think of myself as rational and keen to judge on actual merit and not mythology. ...
- 5 of the Most Dangerous Acts of Incitement From Israel This Week: Netanyahu's
- By Berko's standards, Israel cannot be a Jewish state because the Hebrew language does not have letters that make the sounds J and W.
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Calovini: 67th wedding anniversary
ALBERT AND Madelyn Calovini celebrated their 67th wedding anniversary July 12. They were married on July 12, 1947 at St. Mary's Catholic Church, Lafferty with Rev. Joseph Wadoweig officiating. They have two children, Kathy Berus of Pickerington and Paul and his wife, Brenda, of North Royalton, Ohio; two grandsons are Brandon and Darren, also of North Royalton.


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Author Archives: Jeff Owens
Gretsch on '60s U.S. Series TV
Posted: October 1, 2013
Gretsch guitars were all over the tube in the 1960s. Big hollow-body guitars remained in widespread use in rock and pop throughout the entire decade, and it seemed at times as though you couldn't throw a rock without hitting a TV set that was showing some variety or music show featuring some band that had at least one Gretsch instrument in the lineup. Pretty cool.
From the Beatles and the Stones and the Animals on The Ed Sullivan Show to the Kinks on Shivaree to the Zombies on Shindig! and more, Gretsch guitars were a staple on U.S. programming. Even across the pond, the Who's John Entwistle wielded a Gretsch 6070 bass on Ready Steady Go! in 1965.
And yet there was a whole other category of U.S. television programming in the '60s that also showed Gretsch instruments: prime-time series television on the three major networks at the time—ABC, CBS and NBC. Not only did you see and hear Gretsch guitars on variety shows and music shows; you also saw them on top-rated sitcoms, action-packed cop shows, cool spy shows and more.
Here are five notable examples of That Great Gretsch Sound on U.S. network series television in the 1960s. Some of these shows and the musical acts on them are well known and some are pretty obscure, but there's simply no mistaking a Gretsch when you see one.
The Monkees
Gretsch instruments appeared in nearly every Monkees episode from first (Sept. 12, 1966) to last (March 25, 1968). In this clip, from fall 1965 pilot episode "Here Come the Monkees" (which, oddly, aired Nov. 14, 1966, as episode ten), NBC's simian heroes swing their way through "Let's Dance On." Sort of.
And that's three Gretsch guitars out front, wielded not only by Mike Nesmith and Peter Tork, as usual, but here even by Davy Jones. Nesmith's guitar undergoes an interesting change toward the end, but it's nothing compared to the utterly magical transformation of Tork's bass. And pay close attention to the logo on that kick drum head, by the way …
Tags: Boyce and Hart, Buffalo Springfield, Gretsch basses, Gretsch Guitars, I Dream of Jeannie, It Takes a Thief, Mannix, Sundowners, The Flying Nun, The Monkees, The Name of the Game, Yellow Payges
Posted In: Artists Blogs, Home Page, Top Five | Leave a comment
GretschTech: Center-Block Guitars
Posted: August 8, 2013
The coolest new guitars on the block are Gretsch's new "center-block" models. Each distinctively designed instrument boasts "That Great Gretsch Sound" with a solid new sonic advantage in the form of a special spruce center-block design.
These new Gretsch guitars include the G6137TCB Panther Center-Block (pictured), and the G6139CB Falcon™ Center-Block Single-Cutaway and G6139T-CBDC Falcon Center-Block Double Cutaway models, with more to come. All are distinguished by classic pickups and special "thinline"-style bodies (1 ¾" deep, which is unusually thin for a Gretsch hollow-body guitar).
The most distinctive feature, however, is the interior solid spruce center block that runs the length of these thinner bodies. Its presence imparts a twofold sonic advantage.
First, the block's mass and positioning inside the guitar makes the instrument especially "high-gain friendly." In other words, whereas traditional Gretsch hollow-body guitar design never really lent itself to especially hot high-gain signals, the new center-block design does. The center block design delivers the best of both worlds, resulting in great Gretsch hollow-body character with joyously screaming high-gain pickup tone. (more…)
Tags: Center Block, G6137 Panther Center-Block, G6139CB Falcon Center-Block Single-Cutaway, G6139T-CBDC Falcon Center-Block Double Cutaway, Gretsch Panther
Posted In: GretschTech | Leave a comment
GretschTech: Understanding Modern Gretsch Serial Numbers
Posted: July 8, 2013
|Even if this headstock didn't say "Made in Japan," the "J" that begins the serial number indicates that it was.
The serial number on your modern Gretsch guitar or bass contains specific information about where and when it was made. This allows you to accurately date a modern Gretsch guitar by its serial number.
By modern, by the way, we mean since 2003, which is when Gretsch serial numbering took its current form. Various other serial numbering systems existed before then that stretch far back into Gretsch history—all the way back to the very earliest Gretsch guitars of the 1930s. We'll cover those older serial numbering systems in another installment.
As for the present, the modern system is quite simple. Gretsch serial numbers typically appear on the back of the headstock and begin with a two-letter prefix code indicating the country of origin and specific manufacturing facility, followed by numbers indicating year and month of manufacture and sequential order of manufacture.
"JT" is most common among the several two-letter country/factory prefixes, signifying Japan (J) and its Terada (T) factory. Others are "CS" (U.S. Custom Shop), "CY" (China, Yako facility), "JD" (Japan, Dyna Gakki facility), "JF" (Japan, Fuji-Gen Gakki facility), "KP" (Korea, Peerless facility) and "KS" (Korea, Samick/SPG facility).
After the two-letter prefix, two digits designate the year of manufacture; the next two designate the month of manufacture, and the remaining four digits designate the instrument's sequential number among all models built that year. Of those last four sequential-order digits, 0001 through 0100 designate prototype and one-off models, sample instruments and other special instruments; 0101 through 9999 designate all regular production models.
For example then, a modern Gretsch serial number such as "JT07115922" would indicate that the instrument was built in Japan (J) at the Terada factory (T); that it was built in 2007 (07) in November (11); and that it was the 5,922nd production-model instrument made that year. Similarly, "JT12030040" would indicate a non-regular-production instrument built in March 2012 at the Terada factory in Japan, and that it was the 40th among the special-run instruments made that year.
Tags: Gretsch serial numbers
Posted In: GretschTech | 1 Comment
GretschTech: The Baldwin Era
Posted: May 29, 2013
|Late Baldwin-era models: (left to right) The oddly proportioned Roc Jet and Country Roc, and the bizarre TK300 appear in the 1979 Gretsch catalog.
Every once in a while when exploring the Gretsch world, you'll run across mention of the "Baldwin era" or the "Baldwin years." What does this term refer to?
Generally speaking, people use it to refer to Gretsch in the 1970s. More specifically, however, it refers to the period when the Baldwin Piano Company owned Gretsch, which was substantially longer—from summer 1967 to early 1985.
The Baldwin era is a much-maligned period in Gretsch history. The term is often used in an unflattering light to denote generally neglectful Baldwin rule that resulted in a decline in quality, unpopular new instruments, corporate upheaval and dwindling sales that ultimately led to Gretsch guitar production being shut down altogether in 1981.
Gretsch had been a family-run company ever since Friedrich Gretsch founded it in New York in 1883. But in the mid 1960s, then-president Fred Gretsch Jr. purportedly found himself with no heir interested in running the company and decided to sell. Baldwin, riding high at the time and spurred by its 1965 acquisition of U.K. guitar maker Burns, sought to acquire an established U.S. guitar maker and duly turned its attention to Gretsch. The sale was completed on July 31, 1967.
Tags: Atkins Axe, Baldwin era, Baldwin years, Country Roc, Roc Jet, Super Axe, Super Chet, TK300
Posted In: GretschTech, Home Page | Leave a comment
GretschTech: the Zero Fret
Posted: April 8, 2013
What's the deal with the zero fret found on some Gretsch guitars? What is it, why is it there and what does it do?
A "zero fret" is an extra fret located directly in front of the nut. You don't often see them these days, although they were once fairly commonplace. Regarded today as an antiquated feature, they nonetheless still appear on a small number of instruments as an item of vintage-style authenticity.
Nonetheless, a zero fret isn't merely a cosmetic touch—it does serve a subtle purpose appreciated by discerning players. In effect, it takes over the role of the nut in determining string height above the fingerboard. A zero fret can even out string action even more uniformly than the nut.
It's easy to understand how the zero fret achieves this. On most guitars and basses, the nut serves as the anchor point for the vibrating length of the string at that end of the instrument (the bridge saddles serving the same function at the other end of the instrument) and as the string "spacer."
The slots cut into the nut are of a generally uniform depth, but there can be very slight variations, which in turn produce very slight variations in the height of each individual string above the fingerboard. Guitarists with a discerning fretting hand feel may be able to detect such small variances.
The zero fret eliminates these variances and uniformly evens out string height even more finely because all the strings rest on it as they pass over it, with the nut relegated solely to its role of spacing the strings apart evenly across the width of the fingerboard.
Tags: Gretsch Guitars, GretschTech, zero fret
Posted In: GretschTech | Leave a comment
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