text:
Skip to comments.One pill a day could keep food and nicotine cravings away (Rimonabant)
Posted on 03/09/2004 8:58:30 PM PST by FairOpinionEdited on 04/13/2004 1:42:06 AM PDT by Jim Robinson. [history]
NEW ORLEANS Researchers took aim Tuesday at two of the world's leading killers by unveiling a single pill that suppresses the powerful cravings that drive people to overeat and smoke. Doctors don't view the drug, called rimonabant, as a Viagra-like lifestyle enhancer. Instead, they see it as a potential lifesaver that can reduce a constellation of risk factors for diabetes and heart disease.
(Excerpt) Read more at usatoday.com ...
Sounds like a miracle drug!
Because next they will test it on several thousand people and look for unexpected side effects......like sudden death, complete failure of your bone marrow and other such stuff that may not be common but very dangerous.
Sometimes the cure is worse than the disease.
I wish these things would be available faster, too; but I'm glad they're cautious.
In the meantime...
When I was in grad school, I was involved in research using Sanofi's latest cannabinoid antagonist (the early version of Rimonabant) and that was ten years ago. Using SR141716, we found early evidence for the cannabinoid CNS receptor subtypes and their actions. Fascinating stuff.
Again, that was 10 years ago. It usually takes that long to get a drug to the clinical trials and then with great results, another 2-3 years to work through the FDA regulation requirements. Unfortunately, very few people realize how long and how expensive it is to get a drug to market.
What's really sad is that this new class of drugs has been developed from cannabinoid research (that means evil POT) which was strongly "discouraged" by the federal government. This research showed medical potential to an evil drug during the Drug War. The Clinton Administration and the anti-drug groups were very unhappy that such research was going on and the funding dried up. Sanofi was one of the few pharmaceutical companies that kept going.
I'm there dude! I need to invest in this company's stock...
Precisely/I have a friend who did his dissertation on a waste product from a Pacific Ocean sea sponge that slows tumor growth. Helpful drugs can come the most unusual sources.
First, reread the article and the post. This is not about smoked marijuana; it is about cannabinoids, the active agents in marijuana that bind with the cannabinoid receptors in the central and peripheral nervous systems. These receptors have many important roles in pain perception, anxiety and anger pathways, hormonal stress response, hormonal reproduction modulation, and others. The research is important for new treatments such as the one described for cardiac benefits of weight and smoking control.
Second - be careful with the word "never" in medicine and physiology. Marijuana has a long history as a medicine. For instance, the cannibis plant has been used in antiquity in many cultures for pain control. Chinese Emperor Shen Nung's Digest of Herbal Medicine, 2737 BC, lists cannabis as a treatment for digestive disfunctions and maladies now thought to be related to tumor growths. The Greeks and Romans listed it as a medicine for pain and seizures. Serious research began in the 1800's. In 1830's, there were published papers regarding the use of cannibus as an analgesic, anti-spasmodic, and muscle relaxant. Medical papers of the late 1800's and early 1900's listed cannabis as an effective treatment for tetanus, neuralgia, analgesia for persistent pain, uterine hemmorhage, and to relieve withdrawal symptoms of alcoholics. The banning of marijuana in the US stopped research into cannabis derivatives.
Then in the late 1960's, delta-9THC was found to be a powerful anti-epileptic. The FDA was pressured into considering the merits of cannabinoid research. In 1985, dronabinol was approved for the use of allieving the side-effects of chemotherapy and later, the use as an appetite stimulant for anorexia and AIDS therapy. Nabilone was then approved for similar uses. Research into cannabinoids was grudgingly allowed to continue. That lasted until the the end of the G.H.W. Bush administration and the beginning of the Clinton administration when cannabinoid research was again suppressed by the new War on Drugs efforts. Further research was left to less capable and less funded facilities in France, Germany, and Israel. Luckily, it looks like they have been able to produce some good results.
Smoked marijuana difficulties lay in dosage control and lack of purity of the active substances - not basic effectiveness. This is why the research on synthesized agents is necessary.
Also, until cannabinoids were researched with modern understandings of physiology. We were not aware that there is an endogenous cannabinoid pathway system and naturally occurring cannabinoid receptors in the body. Opium research resulted in our understanding the opioid systems in the brain and the mechanism of pain reception in the periphery. Without that, analgesics above the level of aspirin would not be possible. The cannabinoid receptors will have an even wider impact.
What research is this?
If you check again, you will find that the problems are of delivery and purity. Meaning, it can be used as a medicine, has been used as a medicine, but that better ways can be found and now are being found. As the receptors are characterized, localized, and the second messenger systems are elucidated (so far, extensive g-protein use, K+ channels, and glutamate modulation), then more specific substances can be created.
Your blind insistence is like saying opium would never be used as a medicine when it was and it led to morphine, opioid gate-controlled pain perception, then a range of specific agents of better use.
If you ever made a post that had a contribution outside of being merely disruptive, I would be stunned.
I think the burden is on you to show this research.
Cough it up, so to speak :-)
That was MrLeroy's rule. He was banned and now onmyfeet has set the new rule. The one that challenges the post is required to show evidence that it is false.
Then address your concern to
MrLeroy onmyfeet. He is the master controller of these pro-drug propanda threads.
Now if it could only enlarge a penis, spam would be almost defeated with a free market solution.
That's funny. The potheads on FR always say the opposite: that dosage control is better when smoked, and that there are all sorts of magical properties from what normal people call impurities.
Easy. Find me a doctor that recommends smoking for your health.
Not so easy I am afraid. By your standard of "research," abortion is good medicine; I can probably find you docs all over the place to perform that "service" for you.
And on top of that, there are docs in the states that have tried to legitimize "medical mj" who will prescribe it for you.
You're being an ignorant, lying ass as usual. You fail to present any of your 'research' because it doesn't exist. Are you a physician, physician's assistant, any health professional at all? Have you gone through a graduate program in human physiology, pharmacology, microbiology, or neurology? You're completely unable to discern that the research debate was never about efficacy as a medicine but efficiency of delivery and complications of other substances endogenous to the cannabis plant.
Try to get this into your puny brain - Your statement of "will never be a medicine" is blatantly false as smoked marijuana has been used as a medicine in the past and in some quarters is still being used as a medicine. There have been programs in the US with smoked marijuana as a medicine in treatment regimens and there are ongoing ones in Canada. Thus smoked marijuana already is a medicine.
Thus, once again, you are simply repeating a lie to make yourself feel you can be the big argue man in a discussion.
Here's some examples of the research of smoked marijuana as a medicine: An Executive Summary from the National Institute of Medicine, Division of Neuroscience, 1999, recommended the short-term use of smoked marijuana until synthetic cannabinoids were approved or a controlled inhaler was developed. It as approved and served as the basis for a pilot study using smoked marijuana as a medicine - and even attempted to develop an inhaler.
UCSF performed a clinical trial using smoked marijuana in a treatment regimen for AIDS patients, 1997-1998.
The New York Journal of Medicine published a state clinical study in 1988 - "Inhalation Marijuana as an Antiemetic for Cancer Chemotherapy" by Vincent Vinciguerra, MD; Terry Moore, MSW; Eileen Brennan, RN - That would be smoked marijuana as a medicine.
August, 2003, Health Canada approved smoked marijuana for medical use for AIDS patients - again, as a medicine.
March, 2001, the International Association of Physicians in AIDS Care published in their journal a summary of the uses of smoked and derivative marijuana as medicines.
The Annals of Internal Medicine in January 2001 reviewed the uses of smoked marijuana as a medicine.
In April, 2001, Nature published a review of the medical uses of smoked marijuana.
The point studies have made is that a pill with one purified or synthetic cannabinoid is easier to control for dosage, purity, and action. This does not negate smoked marijuana as a medicine. A pill form or solution for injection will replace uses for smoked marijuana. Before morphine was developed, opium was dissolved in ethanol and taken in liquid form as a medicine - then purified and synthesized agents like morphine and codeine were later used for pills and injections as medicines. But the raw opium in ethanol is still considered a medicine.
Do you see how that works? Can you understand such a complex and difficult idea?
Or will you continue your mentality of a spoiled three year old like in other threads and yell, "Is not, is not, is not?"
If someone says they can control the dosage better by smoking, they're either stoned or ignorant. If you had to take a 5 mg dose of widgetol and your choices were to smoke a 'rolled cigarette' of widget leaf containing 3-10 mg of widgetol depending on where it grew, how wet the growing season was, and how long ago it was harvested or 2.5 mg tablets of measured and processed widgetol, which would you use?
As far as impurities, smoked marijuana not only delivers a couple carcinogens but has many other physiologically active substances. That's why early studies had difficulties. It was hard to determine which cannabinoid was the one causing the desired effect and which were causing the side effects - like pain relief versus mental disorientation. With an isolated cannabinoid or a synthetic, the action becomes specific and side effects can be minimized.
No, that's his game. Make a bogus claim, repeat it often as possible instead of responding, attack, lie, and obfuscate. He'd make a good DemoRat.
Again you ignore facts that get in your way. Smoked marijuana already has been and already is a medicine.
Your insistence is like saying George Bush will never be President because he already is President.
Can you grasp that at all? It is too late to say smoked marijuana will never be a medicine after it already has been used as one.
C: Charlton Heston will never be a movie star.
O: What do you mean? Charlton Heston is a great movie star.
C: Charlton Heston will never be a movie star.
O: Heston starred in big films like the Ten Commandments, Ben Hur, Planet of the Apes, Midway, Soylent Green, and Touch of Evil.
C: Charlton Heston will never be a movie star.
O: He may not appear in any more movies now that he's ill but he's one of the all time great movie stars.
C: You made my point. Charlton Heston will never be a movie star.
O: You're an idiot.
C: Charlton Heston will never be a movie star.
That's how all his 'contributions' go.
And there is yet another lie.
Was legalization mentioned anywhere? Did I even hint at legalizing crack?
No - you lied. Again.
Using the body's endogenous cannabinoid receptors to develop and use better cannabinoid medicines for treatment of medical conditions from addiction and obesity to control of chronic pain and epileptic seizures. That was mentioned but you failed to comprehend the subject - again - and had to lie - again.
Do you deny you are for legalization of crack?
I see where you are coming from on this. On the other hand, we do want to make sure that the potential side affects are fully understood. Side affects don't always show up right away.
Have you found help for your cocaine habit?
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
realmagick.com The shrine of knowledge.
Turkey Service Sector
A selection of articles related to turkey service sector.
Original articles from our library related to the Turkey Service Sector. See Table of Contents for further available material (downloadable resources) on Turkey Service Sector.
- King James Bible: Numbers, Chapter 4
- Chapter 4 4:1 And the LORD spake unto Moses and unto Aaron, saying, 4:2 Take the sum of the sons of Kohath from among the sons of Levi, after their families, by the house of their fathers, 4:3 From thirty years old and upward even until fifty years old, all...
Old Testament >> Numbers
- King James Bible: Numbers, Chapter 8
- Chapter 8 8:1 And the LORD spake unto Moses, saying, 8:2 Speak unto Aaron, and say unto him, When thou lightest the lamps, the seven lamps shall give light over against the candlestick. 8:3 And Aaron did so; he lighted the lamps thereof over against the...
Old Testament >> Numbers
- King James Bible: Numbers, Chapter 18
- Chapter 18 18:1 And the LORD said unto Aaron, Thou and thy sons and thy father's house with thee shall bear the iniquity of the sanctuary: and thou and thy sons with thee shall bear the iniquity of your priesthood. 18:2 And thy brethren also of the tribe of...
Old Testament >> Numbers
- Jesus Christ! You're acting like one of those Christians
- "He drew a circle that shut me out— Heretic, rebel, a thing to flout. But Love and I had the wit to win; We drew a circle that took him in!" – Edwin Markham The room was filled with Pagans, Witches and a few Asatru. The discussion had flowed from &qu...
Paganism & Wicca >> Daily Life
- Survivalists' Guide for the New Millennium: Chapter 5
- WHERE I LAY MY HEAD IS HOME A foot and light-hearted I take to the open road, Healthy, free, and the world before me, The long brown path before me leading Wherever I choose. Henceforth I ask not for good fortune, I myself am good fortune, Henceforth I...
Philosophy >> Survivalists Guide for the New Millennium
- King James Bible: Exodus, Chapter 39
- Chapter 39 39:1 And of the blue, and purple, and scarlet, they made cloths of service, to do service in the holy place, and made the holy garments for Aaron; as the LORD commanded Moses. 39:2 And he made the ephod of gold, blue, and purple, and scarlet, and...
Old Testament >> Exodus
- Mariah Carey
- From the position of her birth Sun in Aries and looking at the aspects, we can understand that her career has no been easy; many problems must have tormented her and made her insecure along her way. Her teenage years have not been very happy; she did not have...
Astrology >> Horoscopes of Fameous People
Turkey Service Sector is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Turkey Service Sector books and related discussion.
Suggested Pdf Resources
- Business Services Sector in Turkey - Invest in Turkey
- Investment Support and Promotion Agency of Turkey. 4. IV.
- www.invest.gov.tr
- The Financial Services Sector in Turkey - Invest in Turkey
- Dec 1, 2015 The Turkish financial sector proved resilient during the global financial ... Milestones of Turkey's Financial Services Industry. Establishment of ...
- www.invest.gov.tr
- Ernst & Young's attractiveness survey Turkey 2013 The shift, the
- Apr 9, 2013 How FDI in Turkey compares with global investment trends; .... were business and financial services, and the leading sectors in terms of value ...
- www.ey.com
- Report No. 82307-TR - World Bank
- May 5, 2014 Trade in Services Dataset. IMF ... Turkey Country Economic Memorandum (CEM) .
- www.worldbank.org
- upgrading the us-turkey commercial relationship - U.S. Chamber of
- U.S.-‐Turkey Trade and Investment–Growth and Potential.
- www.turkheritage.org
Suggested News Resources
- Turkish military struggles to find new recruits
- As of March 1, there were 10,413 contractual soldiers in service. ... That is the idea behind the first public service TV advertisement the TSK has produced, which will be aired by Turkey's abundant TV channels.
- Halle Berry Back in the Spy Game for 'Kingsman 2'
- So far, the film industry has not seen significant interference by Wanda in the operation of AMC in North America. The Carmike deal, in fact, was said to originate entirely from the U.S.
- Halliburton-Baker Hughes Deal EU Decision Expected by July
- Baker Hughes is also a major oilfield service firm providing an array of services to the global oil and gas industry. Currently, Halliburton carries a Zacks Rank #5 (Strong Sell) whereas Baker Hughes carries a Zacks Rank #4 (Sell).
- Trudy Rubin: At the front with Kurdish forces
- His 15,000 peshmerga are responsible for the hottest sector, but he doesn't have enough weapons. "We still lack ... The Iraqi Counterterrorism Service, which includes the country's top security forces, recently helped liberate Ramadi.
- Why Turkish women are opting out of the workforce
- A study called "Research on problems and obstacles for the promotion of women working in the service sector," published by the Women and Democracy Association (KADEM) Feb. 16, provides a thorough analysis of the problems that working women in ...
Suggested Web Resources
- Financial Services - Invest in Turkey
- Information about Turkey's financial services sector, with a detailed sector report and a SWOT analysis, including advantages the sector offers.
- www.invest.gov.tr
- Business Services Sector in Turkey - Invest in Turkey
- Investment Support and Promotion Agency of Turkey. 4. IV.
- www.invest.gov.tr
- #54 Turkey - Forbes.com
- Oct 3, 2011 Turkey's economy is increasingly driven by its industry and service sectors, although its traditional agriculture sector still accounts for about ...
- www.forbes.com
- FOCUS on TURKEY (Services Sector Index of Turkey) - Focusmm.com
- The services sector of Turkey is a rising star of the country's fast growing economy. You will find very friendly attitude and promp service at most places...
- www.focusmm.com
- Economy of Turkey - Wikipedia, the free encyclopedia
- Turkey has the world's 18th largest nominal GDP, and 17th largest GDP by PPP. The country is ... 2.
- en.wikipedia.org
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Turkey Service Sector Topics
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text:
A 48-team World Cup? Here's how it would work.
FIFA president Gianni Infantino seems to think bigger is indeed better.
The Fédération Internationale de Football Association (English: International Federation of Association Football), commonly known by the acronym FIFA (usual /ˈfiːfə/), is the international governing body of association football, futsal and beach soccer. Its membership comprises 209 national associations. Its headquarters are in Zurich, Switzerland, and its president is Sepp Blatter. FIFA is responsible for the organisation of football's major international tournaments, notably the World Cup.
The need for a single body to oversee the game became apparent at the beginning of the 20th century with the increasing popularity of international fixtures. FIFA was founded in Paris on 21 May 1904; the French name and acronym persist even outside French-speaking countries. The founding members were the national associations of Belgium, Denmark, France, the Netherlands, Portugal, Spain (represented by Madrid Football Club; the Spanish federation was not created until 1913), Sweden and Switzerland...
FIFA president Gianni Infantino seems to think bigger is indeed better.
Introducing FIFA roommate.
The Journey is a new mode that joins all the expected annual enhancements that a new 'FIFA' game brings.
FIFA lost more than $100 million last year, but Sepp Blatter still got his pay day.
FIFA is seeking to claim "tens of millions of dollars" in bribe money seized by U.S. federal prosecutors.
Gianni Infanto takes over as FIFA president with much work to do.
Sepp Blatter says he will "always be a president," lauds American baseball stadiums and gets inside the mind of ISIS.
Everything you need to know ahead of the FIFA election that will decide a new president of global soccer this Friday.
FIFA has fired Jerome Valcke for the second time, cutting ties with the secretary general four months after he was suspended while under investigation for wrongdoing.
"I am sorry for football."
"I am sorry for football."
The widening bribery case has rocked soccer's scandal-hit governing body.
Sepp Blatter's and Michel Platini's suspensions from FIFA couldn't have come on a better day for creative, sensitive football fans: National Poetry Day.
The criminal case centers on Blatter allegedly misusing FIFA money.
The Hong Kong Football Association was fined HK$40,000 (US$5,161).
Coca-Cola, Visa and McDonald's call for Sepp Blatter to resign. You can probably guess his response.
The former FIFA vice president was banned from soccer for life on Tuesday, accused of repeated acts of bribery related to World Cup bidding votes.
The office of the Swiss Attorney General says it has opened criminal proceedings into FIFA president Sepp Blatter, according to numerous reports.
"This global response sends a clear message: You are on the wrong side of progress and do a disservice to the integrity of this wonderful sport."
This is real life. This is not a drill.
John Oliver roasting FIFA never gets old.
Wow. Such FIFA. Very money. When former FIFA vice president Jeffrey Webb -- indicted as part of the U.S. Justice Department's continuing crackdown on corruption in world soccer's governing body -- was forced in federal court to secure a $10 million b...
Sepp Blatter was not impressed.
It was the end of the career of the longtime most senior American in world football.
Genius is not exclusive to the men's game. These women are athletic warriors.
U-S-A! U-S-A! U-S-A! in 140 characters.
Scandal, corruption, goooaaaallllls — this film will have it all.
Australia's soccer team, the Matilda's, have upset Brazil in a historic FIFA women's World Cup win in Canada.
Former FIFA executive committee member Chuck Blazer agreed to act undercover for U.S. prosecutors.


text:
Heaven guild on pardioc server [us]
still recruiting.
7 spots left at the moment
looking for people with at least a little general mmorpg experience.
but we're not too fussy about lv's
aslong as you aint a complete ass hat and have a half decent IQ then its all good.
If you wanna join just leave a msg here or get at me or another member in game.
ign is TriggerHappy
what time are you usually on?
i wanna join
i feel so lonely :puppy:
im not very active atm.
helping a friend out on another game.
i've left the guild in goodhands tho^^
try and pm Gelato or Kiora.
tell them you know me and they'll be happy to help ~
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text:
Olympus E-450 DSLR debuts
Olympus announced a brand new camera today that targets the entry-level market. The E-450 is a DSLR that provides a cheaper alternative to the more expensive models while still offering up a decent amount of features.
Olympus announced a brand new camera today that targets the entry-level market. The E-450 is a DSLR that provides a cheaper alternative to the more expensive models while still offering up a decent amount of features.
Previously announced and is scheduled to set free this weekend in Japan, Olympus has today postponed the only DSLR announced in 2009 so far – Evolt E-620 – to March 20, details of the holdback were not disclosed.
Olympus has today announced a firmware update for its Zuiko Digital ED 9-18mm F4.0-5.6, the Four Thirds System standard wide-angle zoom lens, to further improve "IMAGER AF operation under certain conditions".
To load the firmware, both camera and lens are required; for Olympus, update can be applied via the camera supplied software, while Panasonic user can obtain a firmware updater via Olympus website here.
What was the highlight of PMA 2009? The introduction of a new breed Samsung's NX hybrid camera, or its counterpart Micro 4/3 standard from the Panasonic GH1 and Olympus E-620? The former gets Full HD recording at 24hz capability, while the latter boosts World's most compact anti-blurred DSLR. We covered the Samsung and Panasonic briefly in previous posts, and now is Olympus's turn.
Since there's no sight of new DSLR announced from the top-three so far, rugged cameras are probably one of the highlights in PMA 2009 asides from the Superzooms. Among the few, Olympus has the best presentation to simulate their 4th-gen Tough cameras workability in extreme conditions.
At the Olympus booth, we get to play with the only DSLR announced so far (E-620), but what caught our attention is the their tough cameras' presentation. Last time our reader mentioned having video clip to show its ruggedness, you get your wishes, folks. The Rugged Camera Expert has put words in action. In this video demo, you'll see the new Stylus Tough series cameras get pressed at 188lb, dropped from 6-feet, submerged completely in water, and nothing went wrong; it still worked. (video after the cut)
Olympus has today announced a new Four Thirds standard entry-level DSLR with features and price that would put smiles on many fans' faces. The E-620 packed many of the features from E-30, which included the newly developed 12.3 MP "Live MOS" image sensor and a 2.7-inch tilt-swivel LCD, in a smaller and lighter chassis.
Olympus is readying two more cameras for the gauntlet - the STYLUS TOUGH-8000 and STYLUS TOUGH-6000. In case you haven't noticed, these cameras are supposed to be really tough.
Olympus has announced they will be introducing the next round of rugged cameras in January under the brand "TOUGH." These cameras are designed to take amazing photos in the most extreme outdoor conditions no matter where you are you what you are doing.
Apparently the everything-proof Olympus Stylus SW cameras haven't get enough publicity of it's toughness in handling most challenging shooting grounds. The company has reinforced the shockproof, waterproof, freezeproof, crushproof and dustproof Stylus with a better title – Stylus TOUGH, a name with implication of roughness, message received!
Olympus's Marketing director at Europe division said consumer is looking for digicams that define durability in additional to the core image features. Their existing Stylus SW series offer just that, a little twist in marketing drawing board would reflect the true nature of the SW series.
Olympus announced the development of a new Four-Thirds complaint Digital SLR back at Photokina, with an estimate launch date in the first quarter of 2009. The announcement has come early; folks at Cnet have jumped the gun with an officially launch of the New EVOLT but the article was later pulled. So there you have it, the unnamed prototype at Germany has an official title, a 12.3 megapixel Olympus midrange E-30 EVOLT to bridge the gap between the E-3 and E-520.
Can't wait for the new E-System? Need a compact DSLR for the holiday's season? Olympus is offering its limited edition E-420 Komachi Kit for the Holidays. A bundle kit comes with the company's ultra compact 10-megapixel E-420 DSLR, a thin profile ZUIKO 25mm 1:2.8 Digital pancake lens with a retro handmade leather case and strap; packs together accessories like a 1GB CF card, LCD lens protector and a lens cloth. Is that not a perfect holiday gift box or what?
Put on your best outfit and get ready for bling themed party, and take along Olympus's limited edition Stylus 1040 Crystal digicam to capture the cherished memories. Olympus has stamped its Stylus 1040 with limited feature to capture beauty from the glittering world of fashion with 98 Swarovski crystals on the sliding lens barrier. PS- sexy model not included.


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Plants vs. Zombies 2 is a strategy, role playing pc game released in 2013 and developed by Electronic Arts. First developed for iOS and Android. Now available for PC computers.
In this battle between Plants vs Zombies, Crazy Dave takes his love for tacos a little too far.
He decides to goes back to the past using a traveling machine called Penny just to eat the same tacos he ate in the past. However, not all goes as planned. Penny goes haywired and takes Crazy Dave back to Ancient Egypt!
Plants Vs Zombies 2 for pc also takes you to the Pirate Seas, the Wild West, the Far Future, the Dark Ages and to Big Wave Beach.
To expand your gameplay experience each world has three levels and different goals according to each level.
Your goal could be to pair up symbols, reach a certain score, kills as many zombies as possible, etc.
The chinese version of Plants vs. Zombies 2 for pc has yet another world called Kung-Fu.
This world has the least amount of plants, but the game itself has 35 levels.
Plants Vs Zombies 2 Features
• Massive Zombie Attacks
• Stronger Zombies
• Multiple Maps
• Carnivorous Plants
• Keys to other Worlds
What more could you want?
If you want to test your strategy and defense skills, coordination and resource management, Plants vs Zombies 2 is the perfect game for you.
Download Plants Vs Zombies 2 now!!!


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CFR Symposium: The International and the Domestic - Latin America and U.S. Policies and Politics, Session Two
Second session of a forum on Latin American influence on U.S. policies and politics with an emphasis on trade.
Speaker: Edward Alden, Bernard L. Schwartz Senior Fellow
January 4, 2012
A major overhaul of U.S. immigration laws is not realistic in the current political climate, yet the winner of the 2012 presidential election still must confront the issue of millions of illegal immigrants, says CFR's Bernard L. Schwartz Senior Fellow Edward Alden. "It will likely take a level of leadership out of the president and out of Congress that we haven't seen in recent years," Alden says in a CFR 2012 election video issue brief. "It may be too much to hope for."
Citing the failures of the past three administrations, Alden says the best that can be expected is a series of piecemeal reforms to longstanding problems with U.S. immigration laws. Recent reductions in illegal crossings on the Mexico border have shown that U.S. border security is dramatically improved. But Alden says enforcement alone is not going to solve the problem of legacy illegal immigrants, "and it hurts our economy to spend that much on deportation."
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Kurlantzick offers the sharpest analysis yet of what state capitalism's emergence means for democratic politics around the world. More
In a cogent analysis of why the United States is losing ground as a world power, Blackwill and Harris explore the statecraft of geoeconomics. More
Takeyh and Simon reframe the legacy of U.S. involvement in the Arab world from 1945 to 1991 and shed new light on the makings of the contemporary Middle East. More
The Task Force recommends revising U.S. policy toward North Korea to break the cycle of North Korean provocation and promote stability in Northeast Asia.
India now matters to U.S. interests in virtually every dimension. This Independent Task Force report assesses the current situation in India and the U.S.-India relationship, and suggests a new model for partnership with a rising India.
Rates of heart disease, cancer, diabetes, and other noncommunicable diseases (NCDs) in low- and middle-income countries are increasing faster than in wealthier countries. The report outlines a plan for collective action on this growing epidemic.
This report asserts that elevating and prioritizing the U.S.-Canada-Mexico relationship offers the best opportunity for strengthening the United States and its place in the world.
To ensure the success of Myanmar's historic democratic transition, the United States should revise its outdated and counterproductive sanctions policy.
Blackwill and Campbell analyze the rise of Chinese President Xi Jinping and call for a new American grand strategy for Asia.
Williams argues that greater U.S. involvement is necessary to enhance the quality and success of peacekeeping missions.
Learn more about CFR's mission and its work over the past year in the 2015 Annual Report. The Annual Report spotlights new initiatives, high-profile events, and authoritative scholarship from CFR experts, and includes a message from CFR President Richard N. Haass.
Read and download »
Second session of a forum on Latin American influence on U.S. policies and politics with an emphasis on trade.
Watch a panel of experts discuss the role of the immigration debate in the 2008 presidential election. This is the third in a series of...
President Obama gave these remarks in Las Vegas on January 29, 2013, the day after a bipartisan group of senators released their framework...
A bipartisan group of eight U.S. senators proposed a framework for immigration reform released January 28, 2013 and President Obama outlined...


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PattyCast is the original Robert Pattinson podcast. Created by the owners of Pattinson Online, the web's top Rob site, PattyCast brings the latest and greatest to Rob's fans. Entertaining and thought-provoking discussions plus a healthy dose of Rob means the ultimate Robert Pattinson podcast!
October 14th, 2008
Episode 2 of 40 episodes
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Creators of the upcoming humor and advice book, Laura Lane and Angela Spera candidly breakdown real-life dating disasters with a new "reason why you're single" every week.


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Issues: signs
Long signals Hilltop Drive & Hillview Drive ► Open3530 Ridgewood Way Richmond, CaliforniaSomeone increased the traffic light signal times at the corner of Hilltop Drive and Hillview Drive. This is causing long lines trying to turn left from Hilltop Drive towards the mall.
wingram (Registered User)It may be that there were traffic sensors at the intersection and that they have failed. Anyway, the problem still exists. Cycle times are on the order of 1 1/2 minutes.
wingram (Registered User)Still not fixed. I think it's likely that the traffic sensors aren't working since I've seen long waits at a red light when there was no cross traffic in sight.
wingram (Registered User)Still not fixed.
Pedestrian signals not working ► ArchivedRobert Miller San Pablo, CAThe pedestrian cross lights (probably the activation buttons) aren't working when attempting to cross Hilltop Drive from Robert Miller in both directions.
Closed wingram (Registered User)I think this was fixed by activating the pedestrian lights at every cycle. This works, however it may have required the cycles to be longer.
Pedestrian cross walk signals can't be activated ► ArchivedHilltop Drive Richmond, CaliforniaThe buttons to activate the pedestrian cross walk signals aren't working on Robert Miller, crossing Hilltop Drive. And please don't "fix" this the way you did the last time by adding the cross walk signals into every cycle; that made the cycle much too long.
- View all 5 Comments
wingram (Registered User)Make that Westbound.
wingram (Registered User)As I reported above, they didn't fix the cross walk activation buttons. Instead they activated the cross walk signal with every cycle of the traffic lights. It's VERY annoying (as a driver) to have to wait an extra 20-30 seconds when trying to cross or turn onto Robert Miller when there are no pedestrians present.
wingram (Registered User)Some progress. The lights have been sped up by eliminating the "fix" mentioned above and the cross walk signals can be activated going up the hill, but they still cannot be activated going down the hill towards the mall.
Closed wingram (Registered User)It looks like they replaced the activation buttons so it's working fine now!
Car pool sign damaged ► Open3223 Pierce St Richmond, CA 94804, USACasual car pool sign bent, backwards. Looks like somebody hit it.· Reported by Tom H · Share · Flag Flagged
Abandoned Cars In Alley ► Open2208 E. Broad St. Richmond, VirginiaThere are two cars left in the alley. This is an ongoing
problem. Please tow these cars; as, there ARE 'No
Parking' signs that are being ignored.· Reported by Geneva · Share · Flag Flagged
9 VotesFix it! Voted!
Poor traffic light signals ► Open5509-5511 Central Ave Richmond, CA 94804, USAThese lights do not allow for safe travel coming down the street to cross Central or to turn onto it. Drivers constantly ignore orange light and block entire intersection and pull through turning left across the light onto central almost hitting cars coming down the hill from San Luis st.· Reported by Spike · Share · Flag Flagged
Audible Pedestrian Signal Not Working ► OpenMoeser And San Pablo Ave Richmond, CAThe APS on the east side of San Pablo is not working.· Reported by Anonymous · Share · Flag Flagged
Laurenteen Brazil (Guest)It sounds like the audible PED button is on San Pablo Ave. If this is correct, I will need to report this problem Caltrans. I will fax it over to them today. I'm not sure what their response time frame is but I will alert them today and they'll probably get it on Monday. Thank you.
2 VotesFix it! Voted!
Sign covered with Graffiti ► Open5501 Jefferson Avenue Richmond, CA 94804, USAYellow diamond sign covered with black marker graffiti.· Reported by An anonymous SeeClickFix user · Share · Flag Flagged
Red LEDs on street crossing sign don't light ► Archived4900-4998 Cutting Blvd Richmond, CA 94804, USAThe street crossing sign on the southwest corner of Cutting and 49th is broken. Red LEDs ("don't walk" portion of sign) do not light.· Reported by Sarah Mercer · Share · Flag Flagged
4 VotesFix it! Voted!
Traffic signal doesn't pick up bikes ► OpenMarina Way S And Wright Ave Richmond, CAThe traffic signal at Marina Way S as it turns left onto Wright Ave does not pick up bicycles in any lane, heading northbound. The same thing applies to eastbound Wright Ave at this intersection, both for traffic heading straight and turning left. This street is part of the Bay Trail so it is very important that bicycles are accommodated.· Reported by Robert Prinz · Share · Flag Flagged


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By Apple
Open iTunes to buy and download apps.
Numbers is the most innovative spreadsheet app ever designed for a mobile device. Created exclusively for iPad, iPhone, and iPod touch, Numbers includes support for Multi-Touch gestures and Smart Zoom so you can create powerful spreadsheets using just your fingers.
Start with one of over 30 Apple-designed templates for your home budget, checklist, invoice, mortgage calculator, and more. Choose from over 250 powerful functions. Tap to add tables, charts, text, and images anywhere on the free-form canvas. Touch and drag your finger to reorder columns and rows and to resize tables. Double-tap a cell to bring up the intelligent keyboard that helps you enter text, formulas, dates and times, or duration. Animate your data with interactive column, bar, scatter, and bubble charts. And with an all-new calculation engine, Numbers is faster than ever before.
With iCloud built in, your spreadsheets are kept up to date across all your devices. And now with the beta release of new collaboration features, your team will be able to work together at the same time on a Mac, iPad, iPhone, or iPod touch — even on a PC using iWork for iCloud.
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• Over 30 Apple-designed templates give your spreadsheets a beautiful start
• Double-tap a cell to access the intelligent keyboard to add text, formulas, dates and times, and more
• Numbers is faster than ever before, with an all-new calculation engine
• Reorder columns and rows, and resize tables, with a touch and a drag
• Import and edit Microsoft Excel and CSV files using Mail, a WebDAV service, or iTunes File Sharing
Beautiful spreadsheets
• Place tables, charts, text, and images anywhere on the free-form canvas
• Update tables, charts, text, and images using beautiful preset styles
• Insert photos and video with the Media Browser
• Create a form to quickly enter data on the go
• Edit down to the pixel with rulers, alignment guides, and powerful graphics tools
Data uncrunched
• Choose from over 250 powerful functions
• Get built-in help and sample formulas for each function
• Sort columns in ascending or descending order
• Hide or unhide rows and columns
• Turn filters on and off in imported spreadsheets
• Insert gorgeous 2D and 3D charts
• Animate data with new interactive column, bar, scatter, and bubble charts
• Change values in cells using sliders, steppers, checkboxes, pop-ups, and star ratings
• Use Undo to go back through your previous changes
• Turn on iCloud so you can access and edit your spreadsheets from your Mac, iPad, iPhone, iPod touch, and iCloud.com
• Access and edit your spreadsheets from a Mac or PC browser at www.icloud.com with Numbers for iCloud
• Numbers automatically saves your documents as you make changes
Share your work
• Use AirDrop to send your spreadsheet to anyone nearby
• Quickly and easily share a link to your work via Mail, Messages, Twitter, or Facebook
• Export your spreadsheet to CSV, PDF, and Microsoft Excel
• Use "Open in Another App" to copy spreadsheets to apps such as Dropbox
• Print wirelessly with AirPrint, including a single tab, or all tabs
Some features may require Internet access; additional fees and terms may apply.
Numbers does not include support for some Chinese, Japanese, or Korean (CJK) text input features such as vertical text.
What's New in Version 3.0
• Real-time collaboration (feature in beta)
- Edit a spreadsheet with others at the same time in Numbers on Mac, iPad, iPhone, and iCloud.com
- Share your spreadsheet publicly or with specific people
- See who else is in a spreadsheet
- See participants' cursors as they're editing
• A new format pane takes advantage of the display on the 12.9-inch iPad Pro
• Improved downloading – Numbers now downloads spreadsheets from iCloud only when you're ready to work on them
• Wide color gamut image support
• Enhanced keyboard navigation and additional keyboard shortcuts
Customer Reviews
File changes don't push to iCloud...
Since the iOS10 update two weeks ago, the push-to-cloud feature which automatically updated edits and eliminated copies on all devices...disappeared. After every edit on my desktop, when I open that file on my iPhone or iPad (both updated to iOS10), I get a message which says, "edits did not upload, do you want to discard or save a copy?" Inevitably, I am accumulating multiple copies of the same spreadsheet because I make constant changes. Why did this feature change? I get this message also if I make changes on my devices & open with another device. I would appreciate an update back to include this useful feature. I have other things to do than maintain copies, I want ONE & any updates made on ANY devices to include edits automatically. No more copies, please. More stars to come, if I get this updated!
Can't read files created on Mac with pre-Sierra numbers?
The newest version with collaboration sounds enticing except that it can't seem to open any documents that I had created on my MacBook and stored in iCloud Drive. It's also less than obvious how to share folders with people.
And the new "feature" that files are only downloaded when they are needed really makes it impossible to work on those occasions where there is no internet (admittedly rare, but still annoying).
Honestly, although I think numbers is innovative in many ways and fun to use on mobile devices, I wouldn't really trust it for much, especially with the iCloud integration. Hoping the initial bugs with collaboration get ironed out as I would love to be able to share simple spreadsheets with my family.
Easy to Use, Lacking in Features
Numbers is easy to understand and a joy to use on my iPad.
But, I your "simplified" formula interface is ridiculously difficult to use--just use the basic formula process that Excel and the old Lotus 1-2-3 software uses. It's really frustrating doing formulas in Numbers.
Also, why, after all these years, haven't you added the ability to change text alignment in cells? This saves on real estate when we're printing spreadsheets out. It's not exactly a power user feature either.
- $9.99
- Category: Productivity
- Updated: Sep 13, 2016
- Version: 3.0
- Size: 407 MB
- Languages: English, Catalan, Croatian, Czech, Danish, Dutch, Finnish, French, German, Greek, Hindi, Hungarian, Indonesian, Italian, Japanese, Korean, Malay, Norwegian, Polish, Portuguese, Romanian, Russian, Simplified Chinese, Slovak, Spanish, Swedish, Thai, Traditional Chinese, Turkish, Ukrainian, Vietnamese
- Seller: ITUNES
- © 2010 - 2016 Apple Inc.
Compatibility: Requires iOS 10.0 or later. Compatible with iPhone, iPad, and iPod touch.


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Three Legged Fox: Maybe I'm Sorry
From the album Not As Far 2009, and from Philadelphia, PA
|Three Legged Fox's second album, "Not As Far," was produced by prominent recording engineer/producer Chris DiBeneditto at Philadelphonic Studios, and features guest performances by members of several national acts including G. Love & Special Sauce, Slightly Stoopid (both fellow Philadelphonic recording artists), SOJA, and John Brown's Body. Fans will find plenty of the reggae influences that marked their first album, but the band's continuing evolution as it explores other aspects of the "organic roots rock" genre is evident in the increasing variety of influences to be heard among the album's 13 songs.
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- myspace.com/threeleggedfox
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- "Maybe I'm Sorry" (mp3)
- from "Not As Far"
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2009 Bodegas Sierra Cantabria Rioja
Producer: Bodegas Sierra Cantabria
Style: Red Wine
Grape Type: Tempranillo
Origin: Spain
Region: Rioja
90 Points | Stephen Tanzer's IWC - November/December 2011
(100% tempranillo): Deep ruby. Aromas of ripe cherry, cassis, blackberry and dark chocolate, with a touch of cola. Lush, layered and focused, with a creamy texture and hefty dark fruit flavors. Shows the ripeness of the year but there's good energy here too. Finishes with smooth tannins, a hint of licorice and very good length. I'll bet that this will be even better in a couple years but it's approachable now.
85 Points | Wine Spectator
88 Points | Robert Parker's The Wine Advocate
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We have measured the linear polarization induced in a beam of submillimeter radiation when it is obliquely reflected by a flat mirror made of aluminum alloy. For angles of incidence in the range 15°–45°, we measured induced polarizations in the range 0.05%–0.25%. Our measurements are within a factor of 2 of theoretical predictions. We conclude that astronomical telescopes that incorporate oblique reflections from good conductors will not introduce spurious polarizations large enough to cause significant problems for submillimeter polarimetric observations.
© 1998 Optical Society of AmericaFull Article | PDF Article


text: Islanders Activate Brian Strait, Joe Finley By Kevin Schultz | Apr 15, 2013 | 2:51PM Share: The Islanders have announced that they have activated defenders Brian Strait and Joe Finley from injured reserve. Strait broke his ankle back on February 18th, while Finley has been out since April 2nd with a lower body injury. Tags: Islanders Share:


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realmagick.com The shrine of knowledge.
Ty Fox Videography
A selection of articles related to ty fox videography.
Original articles from our library related to the Ty Fox Videography. See Table of Contents for further available material (downloadable resources) on Ty Fox Videography.
- King James Bible: Luke, Chapter 13
- Chapter 13 13:1 There were present at that season some that told him of the Galilaeans, whose blood Pilate had mingled with their sacrifices. 13:2 And Jesus answering said unto them, Suppose ye that these Galilaeans were sinners above all the Galilaeans,...
New Testament >> Luke
- Foxglove: Correspondences
- Digitalis purpurea POISON Folk Names: Cow-Flop, Deadmen's Bells, Digitalis, Dog's Finger, Fairy Fingers, Fairy Petticoats, Fairy Thimbles, Fairy Weed, Floppy-Dock, Floptop, Folk's Gloves, Fox Bells, Foxes Glofa, The Great Herb, Lion's Mouth, Lusmore, Lus na...
Herbalism >> Herbs dictionary F
- Elemental Associations
- The earliest of Greek natural philosophers, Thales, in considering which was the most basic element in the cosmos, from which the cosmos was made, supposed that the cosmos was made of Water. Later, Heraclitus decided that the most basic element in the cosmos...
Magick >> The Elements
- Basics of Magick: The Use of Color in Magick
- White | Silver | Grey | Pink | Red | Purple | Brown | Blue | Green | Yellow | Gold | Black In magick, colors represent certain energies, goals, people and non-physical beings, such as deities or spiritual forces. For this reason, you should include candles,...
Symbology >> Colorology
Ty Fox Videography is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Ty Fox Videography books and related discussion.
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- Super Bowl 50 is taking place in San Francisco on Sunday, February 7, 2016.
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- Tripoli embassy to Hillary: Don't push the video angle on the Benghazi attack
- Three days after the attacks on the consulate in Benghazi and the deaths of four Americans, the US embassy in Tripoli urged Hillary Clinton and other State Department officials not to blame it on the YouTube video, "Innocence of Muslims.
- The Media Pounces on Donald Trump: Um, Most White Americans Are Killed by
- Republican presidential candidate Donald Trump addresses supporters during a campaign rally Nov. 23, 2015, in Columbus, Ohio. Ty Wright/Getty Images.
- Measure would deny University of Missouri system funds boost
- A video of one of the protests showed Click calling for "some muscle" to remove a student videographer from the protest area. She told KMIZ-TV on Wednesday that she felt compelled to confront him, citing a lack of campus police, and insisted she wasn't ...
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realmagick.com The shrine of knowledge.
Slope Calculus
A selection of articles related to slope calculus.
Original articles from our library related to the Slope Calculus. See Table of Contents for further available material (downloadable resources) on Slope Calculus.
- Of Master and Discipline
- Part 1 | Part 2 | Part 3 | Part 4 | Part 5 | Commentary Part 1 The following is a fictional account of a spiritual awakening with a factual basis. This five part series is offered to promote and encourage the practices of the World Mind Society, making the...
Mind >> World Mind
- Egyptian Temples, part III: God's Home
- The cult temple in ancient Egypt was more than a place of worship. It was the home of the god, it was believed the deity took up residence in the building and used it more or less for all those various purposes as humans did. It was the place he was given...
Religions >> Egyptian
- Lavender: Solace and Majestic
- Lavender, the Herb of Air, My friend when I am in despair. I ask Earth's blessing to bestow, As I tend and watch you grow. Strong roots and dainty stems, Bring joy to life when pleasure dims. Wee green bud with purple top, All your uses never stop. From...
Herbalism >> Herbs dictionary L
Slope Calculus is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Slope Calculus books and related discussion.
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- It's similarly steep, with negative slope, around day 250 (September 21). And it's flat at about day 170 (June 21) and day 350 (December 21).
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- It's possible these sanctions, in addition to the ones Clinton promoted, affected Iran's calculus in deciding to pursue diplomatic talks. Verdict: Mostly true.
- The Obama Doctrine
- That would change my calculus. That would change my equation." Despite this threat, Obama seemed to many critics to be coldly detached from the suffering of innocent Syrians.
- NBA Week in Review 19: The Specter of Spring
- For those without a discerning eye, there is a slight slope to the data and a quick regression will show a small negative correlation between the team offensive ratings and assists per possession.
- Los Angeles math teacher solves ultimate calculus equation
- The son of Korean immigrants, Yom teaches what is considered the hardest class in school -- Advanced Placement Calculus. "One of my strategies is really to make sure to provide an environment where kids are not ashamed of asking questions," Yom said.
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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