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The Kyle Petty Charity Ride Across America will soon get under way on a 3,800-mile trek from Indian Wells, Calif., to Randleman, N.C., to raise awareness of and funds for the camp for sick children.
The Charity Ride will stop in Birmingham at the Barber Vintage Motorsports Museum. On May 7, beginning at noon, a free public celebration will be held at the museum to welcome the riders.
Anyone who makes a $30 donation to Victory Junction at the event will be able to join the riders for a lunch prepared by Birmingham chef Julia May and a tour of the Museum.
Former NFL great and Heisman Trophy winner Herschel Walker, legendary NASCAR driver Harry Gant and nearly 200 additional participants are scheduled to participate.


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EA has been talking up the battle between Modern Warfare 3 and Battlefield 3 for quite some time now, first in good spirit, then making it downright personal.
Despite all that, company CFO Eric Brown stated at today's Citi 2011 Tech Conference they "don't expect to surpass [the Modern Warfare franchise] this year with Battlefield 3," noting it raked in about 23 million dollars in 2010.
That's not to say EA lacks ambition, mind you. Brown says they anticipate outdoing Bad Company 2, and expect sales numbers to increase each year because the genre is growing, and the Frostbite 2 engine is nothing to scoff at. As of now, Battlefield 3 has brought in 1.25 million pre-orders.

subset: commoncrawl


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Freshman linebacker Ricky Liuchan will grayshirt the 2014 season and join Oregon State in January, according to a team spokesman.
Liuchan is the only known 2014 signee delayed by academic issues. Twenty five freshmen football players, including walk-ons, arrived on campus Monday to begin the Summer Bridge program. They're getting identification cards, attending new-student orientations and settling into dorm rooms.
"Besides the ones I've known before, I haven't really seen the rest of them quite yet," senior defensive end Dylan Wynn said Tuesday morning. "They're all doing their own thing with school and getting acclimated to where we live everyday."
Liuchan's delayed arrival shouldn't hurt the Beavers' 2014 outlook. Linebacker, after all, is their deepest position. OSU returns three senior starters -- D.J. Alexander, Michael Doctor and Jabral Johnson -- as well as quality backups Rommel Mageo, Caleb Saulo and Darrell Songy.
Liuchan was Rivals.com's No. 43 outside linebacker in the 2014 class. He led Mission Hills High School in San Marcos, Calif., to its first section title as a senior, notching more than 100 rushing yards, a pick-six and a forced fumble in a section championship rout of rival Oceanside. Liuchan chose OSU over Arizona State, California and San Diego State, among others.
Two former verbal commitments -- Pittsburg, Calif., running back Harris Ross and Concord, Calif., safety Xavier Crawford -- plan to join Liuchan and the Beavers in January, though they have yet to sign. OSU opens fall camp Aug. 4.
-- Connor Letourneau | @ConnOregonian


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DaShonte Riley, a 6-foot-11 senior center from Detroit Country Day School, says he knew he wanted to come to Syracuse as soon he got back from his official visit three weeks ago. Riley watched the Orange play Georgetown, the school he had originally committed to. "My mom told me to stay open-minded and explore my options, but at the end of the day, I knew where I wanted to go," Riley said.
Riley announced his decision on Thursday, in the end picking Syracuse over Marquette. He had also considered California, Oregon, Oregon State and Virginia. Riley is ranked the 57th best player in the class of 2009 by Scout.com, and the No. 9 center in the class.
The Post-Standard's Mike Waters talked to DaShonte Riley and his mother about why he picked SU and his strengths as a player.
» Scout.com: DaShonte Riley's profile
» Post-Standard: Orange recruiting update
DaShonte Riley highlight video:
More SU basketball:
The Orange men close out the regular season on Saturday at Marquette (2 p.m. on ESPN). Mike Waters takes a look at how senior guard Dominic James' season-ending injury changes Marquette's whole dynamic.
» SU vs. Marquette head-to-head analysis
More local college basketball:
» Poliquin: Cornell is two wins away from return to NCAA Tournament
» Joshua Kruk: Le Moyne men's basketball a win from D-II tourney
Get more local college sports news, and complete Orange basketball coverage on syracuse.com.


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Events for Wednesday, Jun 04, 2014
Military Open House at Joint Base Andrews
- 9:00 - 4:00
- Joint Base Andrews
Address: 1413 Arkansas Road, Andrews Air Force Base, MD 20762, Suite 105 | Directions
Attend this informal—and informative—event to find out everything you need to know about UMUC's programs, offered online and on-site.
- Apply and register for classes.
- Meet with an advisor to learn how to maximize your educational benefits.
- Explore military scholarships and other payment options.
Prospective students who attend the June 4th, 2014 event will be eligible to have the $50 application fee waived. The $100 application fee for the Doctor of Management program cannot be waived.


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By Jason Graziadei
I&M Staff Writer
(June 6, 2013) The suspect in a road-rage incident that ended with the brutal beating of a man near Nantucket Memorial Airport last August pleaded guilty Monday in Nantucket Superior Court, and will serve 30 days in jail.
In a plea agreement with prosecutors, Daniel Guerrlich, 25, admitted to smashing the windows of the victim's car, dragging him from the vehicle, and beating him with an object – believed to be a lug wrench – following a near collision on Old South Road on Aug. 31, 2012.
To read the complete story, pick up the print edition of this week's Inquirer and Mirror or register for the I&M's online edition by clicking here.
For up-to-the-minute information on Nantucket's breaking news, boat and plane cancellations, weather alerts, sports and entertainment news, deals and promotions at island businesses and more, Sign up for Inquirer and Mirror text alerts. Click Here.
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Our Best New Reason to Let Your Bread Get Stale
In our "What People Are Cooking" column, see how our recipes turned out in other cooks' kitchens. Every week we choose a dish that several food bloggers made and feature it here with photos and links. Share your own experience; submit your blog.
- THE RECIPE: Pecan, Bourbon, and Butterscotch Bread Pudding
Bon Appetit, November 2011
- My Best Days Ever: "This recipe arrived in this months Bon Appetit and it made my mouth water. I planned to write a couple of paragraphs on how wonderful it is, how the poppyseeds and pecans add a lovely crunch and the side of butterscotch sauce is just heaven-not to mention the tipple of Bourbon which really sets it apart from other puddings. Did I tell you I love this pudding?!"
- The Parsley Thief: "When I saw this recipe in the November issue of Bon Appetit I knew I would make it. Of course the fact that it was a bread pudding comprised of pecans, and bourbon, and butterscotch sold me. I was intriqued by the use of poppy seeds in this dessert. Poppy seeds in bread pudding? Well, yes…and they work. The little bits of black splattered among all the other rich, creamy goodness add a nice crunch and texture."
- New York City Eats: "All Time BEST Bread Pudding Ever! And I do mean ever! Seriously, I don't know if it is the bread that Fairway Market sent over (thanks Susan!! It's delicious!), the ridiculously amazing recipe from Bon Appetit, or the substitution of Cognac in place of Bourbon but this bread pudding is — OUT OF THIS WORLD. Some of you maybe going, 'Bread pudding, who the heck cares about that?' but I'm telling you friends, this is above and beyond any bread pudding I've ever tasted. "
- Style Nectar:"Pecan, Bourbon and Butterscotch Bread Pudding is as good as it looks, as good as it sounds. Ultra rich. Buttery. Comforting chunks of rustic farmer's bread and pecans soaked in a poppy seed studded custard, baked, then drizzled with Butterscotch Bourbon Sauce. This luscious recipe by Anita Lo is based on a dessert she serves at her acclaimed restaurant, Annisa. Had it for breakfast with my coffee this morning… Making for sweet, sweet memories all day long."
- Frazgo Feasting:"The recipe isn't mine. Its in this months Bon Appetit magazine. It is Pecan, Bourbon and Butterscotch Bread Pudding. Allow me to hurl a few superlatives…it is the absolute best tasting, richest bread pudding I have ever had in my ENTIRE life. "
Bread pudding. You'd be hard pressed to think of a less soulful sweet, and Annisa chef Anita Lo's version has a bourbon kick and poppy seed crunch. She serves the pudding for dessert, but we think it can double as a morning pick-me-up. The butterscotch sauce could stand in for syrup and the custard-soaked bread is practically a pancake, right? See if these bloggers agree. —Chris Malloy


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As many as 65 percent of component suppliers are still not compliant with the European Union's RoHS directive. This surprising figure came out of an industry roundtable convened by Electronic News last week. The group included representatives from component suppliers Actel, IDT and SST among others.
Executives noted that about 35 percent of the components industry is in compliance with RoHS, while the remaining 65 percent are in some stage of compliance. The statistic is unsettling given that any electronic product in production now will probably be distributed past the RoHS deadline, coming up in a quick 11 months.
The discussion revealed that suppliers who are up to date on compliance have been aggressively pursuing the move to green parts for many years. Actel, IDT and SST all described efforts that began three, even four years ago, suggesting that component suppliers who just began moving to compliance over the past couple years may be far behind in meeting the RoHS deadline.
Executives also confirmed the industry notion that competitors will police RoHS violators. They expect compliant companies to promote their compliance as a competitive factor and tip regulators to non-compliant competitors.


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Watch anime online, streaming anime episodes watch anime online, you are watching Major Episode 128 English subbed online for free. Anime guide, Major Episode 128 English subEpisode Description : Measure! My Father's BackThe score is 6-6 as the teams enter into the 16th inning, and even Goro says it's time for the game to finish. Toshi gets what could be his final shot against Gibson as he steps up with a runner at third hoping to put Japan ahead. Toshi makes contact, and as his bat breaks it hits Gibson in the chest. Gibson recovers enough to get the out at home, but not without everyone worrying if it could end up like Honda all over. Gibson finishes the inning without giving up any runs. Goro meanwhile has started to get tired, and he walks the first two batters before giving up a hit. It's Gibson Junior's turn to bat, but he has gone into the locker room to keep an eye on his dad.
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Responding to Mark Schleifstein's story "Corps decides on armoring for New Orleans area levees," reader johnbgood commented:
"One design consideration probably not considered is the effect of drought, fires from hunters setting the marsh on fire, and animals digging for roots and destroying the grass armor. Then what? Say the drought, fire, or the animals are responsible for the armoring failing.
"The maintenance issue is a real concern. When tractor pulled grass cutters go over uneven ground the deck and blades dig into the ground and shread whatever is underneath. It is highly unlikely that the levees built are as even as the levees built and tested in a Colorado laboratory. The academic world needs to look at the real world, and not just ideal conditions."
Join the conversation; reply to johnbgood.


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Middle East
Bush's 'transfer of power' gambit
By Jack A Smith
Speaking Freely is an Asia Times Online feature that allows guest writers to have their say.
Please click here
if you are interested in contributing.
The war in Iraq may be blowing up in the Bush administration's face, but the White House is conspiring to maintain substantial military, political and economic power in the war-torn country following a deeply suspect "transfer of sovereign power" to an interim Iraqi government on June 30.
The guerrilla resistance, combined with Washington's bungling of the occupation, have compelled President George W Bush and his neo-conservative advisors to reconfigure or shelve several of their more grandiose post-war plans. But the US government has no intention to simply relinquish its expensively obtained hegemony over a Baghdad government possessing the world's second largest proven petroleum reserves and strategically located to influence the entire Middle East.
The US must execute three complex maneuvers to accomplish its goal:
1. Inducing the United Nations to become an active partner in Iraq, providing the White House with respectable support and camouflage for its endeavors in exchange for the appearance of shared authority.
2. Taking measures to ensure that a huge American occupation force remains in the country, and that Washington will exercise great influence over the new permanent government and Iraq's economy by establishing a virtual parallel regime of its own in Baghdad.
3. Containing the resistance by any means necessary - from massive retaliation against the Sunni fighters and their new allies led by Shi'ite cleric Muqtada al-Sadr, to making deals with Grand Ayatollah Ali al-Sistani, the principal leader of the majority Shi'ite population. The entire plan may fail unless the resistance is destroyed or reduced to occasional attacks against Pentagon-controlled Iraqi security forces.
An important consequence of this plan, if successful in its opening stages, is that it may help reelect Bush of Baghdad to a second term in November. Even if he is defeated by the Democrats, a John Kerry administration does not appear politically indisposed to implementing a similar design.
The Bush administration was so cocooned in superpower hubris in the months leading to the preemptive invasion of Iraq a year ago that it publicly dismissed the UN as irrelevant, and refused to assign the world organization more than menial responsibilities. The transformation of the occupation into a fiasco turned the tide.
Almost everything went wrong for the US after toppling Saddam Hussein - from underestimating the opposition of Iraqi people, to the loss of credibility when it proved unable to locate Iraq's alleged weapons of mass destruction; from the development of an effective national liberation struggle, to the increasing number of GIs who have been killed and wounded (over 10,000 Iraqi civilian casualties don't seem to count); from the problems of occupying a nation in ruins, to popular rejection of the puppet government selected by the Pentagon; from the disinclination of allies to support a clearly unjust and illegal war, to the worldwide condemnation of the invasion and occupation.
The UN is acceding to Washington's wishes so far, despite grave reservations about Bush's actions. This is not unexpected. The global body never criticized the US for violating its charter and illegally invading in the first place, and it has subsequently approved measures recognizing Washington's administration of the occupation.
At this stage, the Bush regime needs the UN to work out the logistics of the supposed transfer of power to the Iraqis June 30. This is because the powerful Shi'ites have successfully vetoed several previous US transitional plans. They believe that their 65 percent majority entitles them to power commensurate to their numbers in the new "democratic" government.
UN Secretary General Kofi Annan has named Lakhdar Brahimi, a former Algerian foreign minister, as his special envoy to Iraq. He then agreed that Robert Blackwill, the White House deputy national security adviser responsible for Iraq, should work with the special envoy in developing the "Brahimi Plan" that was unveiled in vague, provisional terms last week. The Bush administration rushed to accept the "UN proposal" on April 15. The plan calls for dissolving the highly unpopular Iraq Governing Council (IGC), justly considered a US puppet, and replacing it on July 1 with a caretaker government to be selected by the UN "after consultations" with the US and Iraqi parties. Full elections for a permanent regime would be held in January.
It now seems the UN will create the structure of a new regime, among attendant tasks, assuming the various parties which rejected Washington's formulations can agree to operate within Brahimi's guidelines.
This does not mean the Bush administration has lost its power in Iraq. The US has handed an exceedingly hot potato to the UN, while retaining decisive power where it matters. As the New York Times stated in an article April 16: "Administration officials asserted that, even with the UN overseeing the selection of a caretaker government and then holding an election and helping the Iraqis write a constitution, American influence on the process would be considerable - not least because the US is to remain in charge of military and security matters and will be the country's main source of economic aid." Actually, the US is in a stronger position because it conveys the impression Bush is working with the UN to "create democracy" in Iraq.
Bush and L Paul Bremer, who heads the Coalition Provisional Authority (CPA), have been taking steps for many months to assure that the US will continue to wield decisive influence after the "transfer of power" to the Iraqis. Here is how it will work:
Some 110,000 US troops are scheduled to remain in Iraq for several years. They will be ensconced in 14 permanent military camps, designed as highly fortified enclaves outside big cities to minimize the number of American casualties. The GIs will fight only if US-controlled Iraqi security forces cannot handle a particular crisis, or if it becomes necessary for Washington to protect its own economic and political interests against an insurrection, or as a show of force to keep Baghdad in line.
The Bush administration expects that the new government will "invite" US troops to remain in the country under the usual "status of forces" agreement with various foreign countries hosting some 750 other US bases. If the Iraqis balk at an occupation agreement, Washington will interpret UN Security Council resolution 1551 as providing the needed authority. The resolution was passed last fall to "legalize" the US-led occupation. As now, the commanding general of the occupation force will report directly to the Pentagon, bypassing Iraqi and US civilian authorities in the country.
The White House is creating a parallel political regime in Baghdad. It has ordered construction of the largest American embassy in the world to accommodate an extraordinary 3,000 employees, far larger than any other US diplomatic mission. Many of these "diplomats" will be assigned to the various Iraqi government departments as "advisers," or co-equal authorities, effectively sharing in the operations of the Iraqi government. According to the progressive British journalist and film-maker John Pilger, writing in the New Statesman on April 17: "There will be no handover [of power]. The new regime will be stooges, with each ministry controlled by American officials and with its stooge army and stooge police force run by the Americans."
Evidence that the US plans to impose itself on future Iraqi governments is embedded in the interim constitution passed by the IGC: all laws and regulations emanating from the CPA must be recognized as valid in the future. Whether this clause is to be retained in the permanent constitution is not known. Many CPA regulations are designed to control the economy. For example, they include rules to speed the privatization of Iraq's state enterprises and property, and for the disposition of the country's petroleum resources. The CPA has also established a number of "independent" regulators to share power in various government ministries.
The US has another coercive weapon with which to manipulate the new government. It controls $18.4 billion in aid for desperately needed reconstruction tasks, without which Iraq will remain a ruin. Washington will decide which firms get the contracts for this aid.
Bush has just selected John D Negroponte, Washington's ambassador to the UN, to function as the envoy to Baghdad. Considering the size and nature of his assignment, he will serve in effect as prime minister of the parallel government, reporting to the State Department. Negroponte is an old hand at subversion, after his years as ambassador to Honduras when the country was used to support counter-revolutionary Contras in neighboring Nicaragua. He has been widely criticized by the left for covering up for human rights abuses in Honduras.
The Bush administration's intention to create a neo-colonial dependency under the guise of building democracy and restoring sovereignty may well degenerate into a fragile house of cards destined to collapse sooner than later. The two most important internal factors in making this determination will be the resistance of national liberation forces and the relationship of the Shi'ite majority to the new government and the US occupation authority.
The Pentagon's biggest immediate headache is the nationalist guerrilla resistance led by the Arab Sunni minority and joined by a small number of foreign fighters. A much more throbbing headache is lurking in the background - the possibility that the Shi'ite majority will refuse to cooperate with the US-UN authorities or, worse yet, join the rebellion. (The Kurds in the north are Sunnis, but their singular interest in obtaining as much autonomy as possible by cooperating with the US, eventually leading to an independent Kurdistan, is another matter entirely.)
The CPA was reported to think the Sunni guerrilla forces were becoming weaker after attaining an apogee last fall. The upsurge in fighting in Fallujah, Njaf and other cities throughout April proved decidedly otherwise, particularly when Muqtada al-Sadr's Mahdi Army joined the struggle - at least in part as retaliation for Bremer's decision to shut down his movement's newspaper, al-Hawza. The main fighting lasted for three weeks and over 100 GIs were killed. American forces responded with an onslaught that killed up to 1,000 Iraqis, the majority of whom, as customary, were civilians. The behavior of US troops in selecting targets was so questionable that several members of the IGC registered stern protests and a few resigned.
One of the lessons US generals learned from the events of April is that the colonial army and police force it is organizing to fight the insurrection in place of American troops cannot be counted on - a factor that has the potential of scuttling plans for a long-term occupation. One entire Iraqi brigade of 650 soldiers simply refused orders to enter Fallujah, arguing, "We did not sign up to fight Iraqis," according to the April 10 Washington Post. The same article reported that the April uprising caused up to 25 percent of Iraqi security forces to "quit, change sides or otherwise fail to perform their duties". So far, the US has trained 150,000 Iraqi police and military recruits, largely drawn from the desperately poor army of the unemployed. The majority have joined in order to feed their families and have no loyalty to the modern crusaders occupying their country.
The evident unreliability of the Iraqi forces is a serious problem for the Pentagon, which is running out of soldiers because so many of them are stationed throughout the world. At this time there are 134,000 US troops in Iraq (not counting up to 20,000 mercenaries providing many of the security services once carried out by the armed forces). Bush promises to send more troops when needed, but there are not enough GIs to fight in a large and sustained guerrilla war, particularly since the 17,500-soldier "coalition" force is being depleted by the defection of Spain (1,300 troops), Honduras (370) and possibly other countries.
Of great importance during the latest uprising was an April 10 anti-occupation rally of some 200,000 people in Baghdad with Sunni and Shi'ite together praising the armed struggle conducted simultaneously by both religious communities. The unity shown on that day is in contrast to speculation from some quarters about an eventual Sunni-Shi'ite civil war.
Most of the Shi'ite community remained quiescent during the April confrontations under instructions from Sistani, who is playing a complicated game. He despises the Americans, but recognizes events may maneuver them into granting the Shi'ite principal control of the new Iraqi government. In the extreme, a US deal with Shi'ite Iran's ruling ayatollahs cannot be ruled out: an exchange of Shi'ite predominance in Iraq, plus less hostility from Washington toward "rogue" Tehran, for Iran's guarantee to keep a Shi'ite government in Baghdad within America's bounds.
Muqtada, an Islamic radical in his early 30s, is decidedly subordinate to Sistani in rank. But he is the son of Grand Ayatollah Muhammad al-Sadr, a symbol of resistance to the Saddam regime, who was slain five years ago, allegedly by agents of the former Baghdad government. He could order his forces to join the uprising for good in hopes that this act would prompt other Shi'ites to join them. So far, the main Shi'ite Badr militia has remained passive in compliance with Sistani's wishes.
The situation in Iraq is exceptionally complicated and events are moving at considerable speed. Anything can happen - and probably will, in a matter of weeks or months. Keep your eyes on the "transfer of power" gambit.
Jack A Smith
was the former chief editor of the now defunct US progressive newsweekly The Guardian, and presently the editor of a newsletter devoted to political activism. He resides in the Hudson Valley region of New York in the USA.
Speaking Freely is an Asia Times Online feature that allows guest writers to have their say.
Please click here
if you are interested in contributing.
Apr 23, 2004
More power to the UN's man
(Apr 22, '04)
The United Nations strikes back
(Apr 22, '04)
9-11: The big question remains unasked
(Apr 20, '04)
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a game is a game who gives a stuff if u loseOriginally Posted by dodabird
so we've all heard the complaints about "cheap moves" in msc. while the debate still rages on concerning whether or not these moves are "glitches" or fully intentional, it's prompted me to ask an interesting question: with mario kart wii slated to fully utilize the online gaming features of the wii, what types of "cheap moves" do you think gamers will come up with? it's hard to think of cheap moves in a racing game (i'm not sure if you wanna consider running someone off the road "cheap"), but with the imagination of today's gamers, i'm sure there will be one or two that people complain about. what are your thoughts? what do you think will be considered "cheap" in a game that deliberately gives you weapons to destroy the other racers?
Nintendo On The Islands
a game is a game who gives a stuff if u loseOriginally Posted by dodabird
Spoiler Alert!wii master add me 4087-8521: mario striker charged football uk only 1521-6787-000106289463 & luigi is the games i own wii sports wii play call of duty 3 big brain acadamy spideman 3 metriod prime 3 the legend of zelda twilight princess mario party 8 the godfather pirates of the caribbean tony hawks down hill jams mario stricker charged football super mario galaxy
wow...that has absolutely nothing to do with the thread topic. but sure...a game IS a game, and it's meant to be lost (and won).
Nintendo On The Islands
Well, I guess it comes down to your definition of cheap, but it'll be the same moves you've seen in all the other incarnations of mario kart, I'm sure. Brutal short cuts, getting that red/blue shell to the arse when you're only seconds away from taking first place, tailgating some one just to end up getting slapped with a bananna. I don't consider any of those "cheap" though... don't really consider anything in MSC cheap either for what it's worth.
The only "cheap" thing in strikers is the Hammer. Its ok if you use it once or twice, but some people use it 10 times in a row. It gets annoying and yes, cheap.
But if you can deal with it, maybe your not so good? You cant really spam anything in Mario Kart though.
personally, i think mario kart is designed for cheap shots! As long as it isn't a glitch then I dont mind.
I think that one of the cheap moves will probably be 2 friends 1 tries to win the race , the oder goes the back way and bombs the other players.
But even tho this game is gona RULE
liv buy a wii and play itMario strikers football Charged rulesEven do I reaaali suckpm for for fc (europe only)
This game will include the same things that everyone before had. I don't think there will be too many things that could really disrupt game play. And as far as Mario Kart goes, running people of the road isn't very easy to do.
are you kidding me? that's not cheap....just annoying, you can easily tackle themOriginally Posted by Warrior
what is cheap is when toad, boo, waluigi etc. use their doge to just appear in the net with the ball, hence a goal
but mario kart is all about the cheapness, (blue shell)....so i don't think there would be any specific cheap moves
the mario that's roomed with mush
my wii is not connected to the internet, so i can't play brawl online for a bit....please do not spam inbox with friend code requests
I remember the snaking deal with MKS. snaking was cheap, if you asked me, cause it didn't require much skill to do. But yeah man. MK is all about the Blue Shell just as your about to cross the finish line......ouch.
but my suggestion is, if you find something you don't like about MKWii when it comes out, just [sarcastic]send a bitchy letter to Nintendo.... I'm sure they care[/sarcastic]
Bwii FC : 317 942 875 882Originally Posted by Arauna
MOH: AoWTank
X-Box Live GT: IronLionZion87


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Specialized Treatment Early in Psychosis (STEP) (STEP)
This study has been completed.
Yale University
Information provided by (Responsible Party):
Vinod Srihari, Yale University
ClinicalTrials.gov Identifier:
First received: March 29, 2006
Last updated: September 17, 2013
Last verified: September 2013
|Tracking Information
|First Received Date ICMJE
|March 29, 2006
|Last Updated Date
|September 17, 2013
|Start Date ICMJE
|March 2006
|Primary Completion Date
|August 2013 (final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Rehospitalization measured every 6 months for 5 years. [ Time Frame: Assessed every 6 months ] [ Designated as safety issue: No ]
|Original Primary Outcome Measures ICMJE
|Rehospitalization measured every 6 months for 5 years.
|Change History
|Complete list of historical versions of study NCT00309452 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Specialized Treatment Early in Psychosis (STEP)
|Official Title ICMJE
|Randomized Trial of Usual Care Versus Specialized, Phase-specific Care in the Public Sector for First Episode Psychosis.
|Brief Summary
|The purpose of this study is to understand the effectiveness of a specialized package of phase-specific treatments for individuals in the midst of their first episode of psychosis. The pharmacologic and psychosocial treatments will be delivered within a state public mental health center.
|Detailed Description
|We propose to conduct a clinical trial for first episode psychosis patients not eligible for CMHC services that will compare randomized access to care at CMHC versus the usual procedure of referral to community providers outside CMHC. Patients randomized to access to CMHC services will receive multifaceted, intensive, phase-specific care delivered by a specialized clinical team. This care will include five principal components: antipsychotic prescription, multi-family group therapy, group cognitive behavioral therapy, cognitive remediation and individual case management including supportive, problem solving approaches and a focus on resumption of movement towards educational and/or employment related goals. All consenting subjects will undergo research evaluations every six months for up to five years. Outcomes will be assessed in the domains of re-admission (primary outcome), relapse, symptoms, overall functioning, quality of life, education and employment, treatment satisfaction, adherence, substance use, adverse events (including self-harm) and economic measures including service use, cost of care and forensic data.
|Study Type ICMJE
|Study Phase
|Not Provided
|Study Design ICMJE
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Condition ICMJE
|Schizophrenia and Disorders With Psychotic Features
|Intervention ICMJE
|Study Arm (s)
|Publications *
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Completion Date
|August 2013
|Primary Completion Date
|August 2013 (final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|16 Years to 45 Years (Child, Adult)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|Plan to Share Data
|Not Provided
|IPD Description
|Not Provided
|Responsible Party
|Vinod Srihari, Yale University
|Study Sponsor ICMJE
|Yale University
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|Information Provided By
|Yale University
|Verification Date
|September 2013
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A tiny beach mystery
It was a cloudy day on the Washington coast, the breeze blowing the sound of the waves up the wide expanse of beach. Past the part of the beach that you can drive cars on(!) it was relatively quiet between the surf and the red cliffs. Lost in conversation or my own thoughts, I never would have noticed this unusual scene if my companion hadn't pointed it out. A single ladybug (ladybird, if you wish), was slowly walking along the sand. If you look closely, you can even see the trail it's leaving behind it. What brought it there? Was it in love with a sea turtle? Did it need a break from the rat-race of chasing aphids in the garden? It didn't say.


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- Cut the khap
July 20, 2013
Dressed in jeans? Feasting on chowmein? A Twitter parody of a disapproving khap panchayat is ready with a rap on the knuckle that makes you chuckle.
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Kerala may have a record literacy rate for women but their numbers are growing only in low-paying jobs.
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An eyesore of blue tarpaulin, or a complex warren teeming with promise and enterprise? Describe it how you will but there's no denying its…
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From the Times Of India
Jobs in Detroit's car factories are moving to India.
Chidanand Rajghatta
Can 'bindaas' or 'jhakaas' survive transliteration?
Shobhaa De
India's first superstar died almost a lonely life.
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Fashion, where the old need the young
Many of India's top fashion houses have been around for two decades. It is now time for the next generation to take charge and revitalise these businesses with fresh ideas
Youth and fashion have always had a very strong, yet strained, relationship. The industry is forever chasing new talent and trends. But at the same time, heritage is an integral part of fashion. Watch how fashion houses boast about their pedigree, and their archives.
The fashion industry in India is only about three decades old and senior designers like Tarun Tahilani, Rohit Bal, JJ Valaya, Abu Jani-Sandeep Khosla and Suneet Varma still rule the roost. But the fact is that the industry also needs new talent.
In fact, Gen-Next shows are always among the most attended at the Lakme Fashion Week, and Wills Fashion Week traditionally opens with new talent. This year it opens with Masaba Gupta for Satya Paul. This means those who are neither new nor established have to work doubly hard to woo the market. Even established designers need to think of out-of-the-box to stay relevant. It has to be about being experienced yet fresh. And one way of doing this is to bring in your own Gen-Next line. Ogaan, Neeta Lulla and Ashima Leena have all done this but in three very different ways.
Ogaan has been one of the pioneering multibrand stores. It started in 1989 in Hauz Khas village. Known for young talent and a boho take on style, this 6, 000 square foot store soon became the Capital's most sought after fashion address. Founded by Kavita Bhartia, the Ogaan store became a curator of ethnic-cool. It grew and now has four stores across two cities. Among the first stores to do individual designer promotions, advertising campaigns and also work on visual merchandise, it can be credited with helping fashion grow into an industry. It has managed to maintain its position among top Indian stores despite the new entrants in the market. But in the last two years, Ogaan has stepped up its efforts, and has a better recall value than most other multi-brand stores. The credit for this goes to Kavita's daughter Aashti, who has managed to quietly re-energise the brand. Says Aashti, Ogaan's managing director: "The DNA of the brand is new talent. " She has made sure Ogaan has stayed true to this policy.
The first multi brand to take on Sabyasachi by Sabyasachi (the designer's fusion line) and Rahul Misra's Indian line, and give Pankaj and Nidhi's fashion show line floor space, Ogaan has a new buzz around it. Perhaps the fact that Aashti is not trained in fashion but in business has helped bring in an outsider's perspective. Having seen the brand grow she also has an innate understanding of Ogaan.
Ashima and Leena have been in the industry for over two decades and are known for their love of ethnic embellishments. They lacked fashion buzz, but despite that their label has steadily grown. During the last Delhi Couture Week they received encouraging reviews. Leena's daughter Rhea has now taken over as director of strategy.
A graduate from NIFT Delhi she had her own design studio for a while where she worked on interiors as well as fashion. She has already started making some changes to the line and like Aashti seems to be taking the brand back to its original DNA. "It is about going back to the basics, " she says. For Ashima and Leena, that is couture. This is why the Ashima-Leena store has now moved to Emporio, the address for Indian couture.
The store has an ethnic eclectic interior, which have been designer by Rhea. She is also working on developing a special gota technique for Ashima-Leena which will be trademarked and unveiled at the next fashion week. She is also scouting for suitable place for a flagship store in Mumbai.
At 27, Nishka Lulla is the youngest of designer daughters to enter the industry but she has already managed to carve a niche for herslf. She has been running her own label, Nisshk, for three years now. It is available at mother Neeta's flagship store in Mumbai. Neeta is one of Bollywood's favourite designers -- she has won the Nation Film Award multiple times. Thanks to her work in Lamhe, Chandni and Devdas, she is known for her saris. Nishka's latest collection - which has a very Boho and Indian gypsy feel to it - has received good reviews. It concentrates on print, textile and shape more than embellishment. Much younger and more pret than her mother's label, Nishka's entry into fashion has had a rub-off factor on Neeta's designs and life. And it will prepare her to one day enter her mom's flourishing bridal business.
In Italy, many cult brands like Fendi, Missoni and Hermes are family run and this ensures that the brand's uniqueness is maintained. Now that many Indian fashion brands have reached the two decade mark we are bound to see more youngsters take charge. Ritu Kumar's son Amrish was probably the first in line - five years ago he launched Ritu Kumar's Label. This pret line helped create a new segment for Ritu Kumar, one of Indian's oldest and most respected names in fashion. With others following, our fashion houses can now work with the perfect combination of youth and experience.
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Schmidt, Patricia M. RN, BSN, MHS, CPT, AN*; Sheridan, Robert L. MD, FACS, COL, MC†‡; Moore, Christina L. RN, BSN, MAJ, AN*; Scuba, Steve C. RN, BSN, CPT, AN§; King, Booker T. MD, FACS, LTC(P), MC*; Morrissey, Paul M. MD, FAPA, LTC, MC‖; Cancio, Leopoldo C. MD, FACS, COL, MC*
A large portion of the casualties admitted to military hospitals on the battlefield in Iraq consists of children, of whom 13% had burns. The U.S. Army Combat Support Hospital (CSH) in Baghdad, faced with an influx of such patients, successfully transferred selected burned children by commercial airlines to the Shriners Hospital for Children in Boston, Massachusetts (SHC-B). The authors aimed to document this process, from both an ethical and a procedural standpoint. Care was conducted in six phases: 1) admission to the CSH; 2) selection for transfer; 3) burn care at the CSH; 4) travel to the United States; 5) burn care at the SHC-B; 6) return to Iraq. Transfer and SHC-B care were funded by charitable organizations. A review of patient records was performed. Eight acutely burned pediatric patients participated in this program. All were successfully transferred, treated at SHC-B, and returned to Iraq. They ranged in age from 1.7 to 17 years and in burn size from 6 to 53% of the TBSA. At SHC-B, the hospital length of stay was 14 to 132 days; up to 23 visits to the operating room were performed for acute and reconstructive burn surgery. The cost of war includes the care of injured civilians, and includes burned children. For selected patients, transfer out of the combat zone is one method of fulfilling this obligation.
© 2014 The American Burn Association
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ScoutTV: Bo Wallace
OM Spirit Top Stories
Friday Focus: Ole Miss vs LSUOle Miss travels to Baton Rouge to face SEC West rival LSU on Saturday. Kickoff is set for 8 p.m. CT on ESPN.
OM SpiritYesterday at 11:48 PM
Rebels Preparing for Fournette, GuiceOle Miss defensive end John Youngblood has had his mind on stopping LSU running backs Leonard Fournette and Derrius Guice this week.
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WRs Holding Each Other AccountableAfter some uncharacteristic drops in last Saturday's 34-30 loss against Arkansas, Ole Miss WR Quincy Adeboyejo says the Rebels are keeping each other accountable to prevent dropped…
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Pickett has major breakout potentialOle Miss landed Jamarko Pickett on Thursday. While being a bit off the radar, Pickett shows tremendous upside and long term potential.
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Jamarko Pickett commits to Ole MissOle Miss adds their third pledge of the class, as Jamarko Pickett committed to Andy Kennedy on Thursday.
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FLINT - Happy New Year, you lucky dogs you. It's time once again for my annual predictions column, although to call them predictions is to not give me my due.
Last year, for instance, fully 94 percent of my predictions came true, according to a review by the futurist organization Prognosticators of America. (I could show you the proof but I, uh, lost it in a terrible house fire. Yeah, that's it - a terrible house fire. Which, by the way, I predicted.)
In any case, for an amazing 22nd year in a row, I gaze into the swirling mists inside my crystal ball and intone those famous words "I see London, I see France, I see 2012.
Article Photos
Andy Heller
A full week later, the nation's emergency rooms are still trying to clear the backlog of male patients suffering from head injuries sustained when they gave their wives and/or girlfriends stupid gifts for Christmas, in this case Forever Lazy, those Snuggie-like fleece body-suits you wear like pajamas. "Happens every year," says an exhausted ER trauma doctor. "You'd think guys would learn."
The first Republican presidential caucus takes place in Iowa. Voters overwhelmingly select "None of the above" as their top choice. One voter sums up the feelings of many: "Have you seen these people? Each one's crazier than the last."
The Detroit Lions win their final regular season game by forfeit when the entire Green Bay Packers team mysteriously comes down with the trots. In the ensuing investigation, known bad boy Ndamukong Suh is spotted on a security camera leaving the Packers locker room with an empty case of Ex-Lax, which, an investigation reveals, he laid out on the training table like a platter of chocolates. He is suspended for 86 years by the league.
Gov. Rick Snyder appoints an emergency financial manager for Detroit who takes one look at Detroit's books and declares it beyond saving. Later that week he sells the city for $129 to the pawn shop on TV's "Hardcore Pawn."
The Detroit Lions win the Super Bowl, causing air traffic tie-ups across the nation due to a sudden rash of flying pigs. Madonna performs the half-time show causing millions of viewers under the age of 30 to go, "Who?"
At the American Music Awards, Justin Bieber is given the Grammy for "Teenage heart-throb that other teenage boys would most like to beat with a stick." Madonna wins a lifetime achievement award, causing millions of people under the age of 30 to say, "Hey, isn't that the old lady who performed at the Super Bowl?"
The U.S. Food and Drug Administration forces "American Idol" to carry a warning label for diabetics that says, "Caution: Exposure to Steven Tyler's sickly sweet descriptions of singers who are, at best, marginally talented may induce nausea and/or coma."
For an amazing 22nd year in a row, March is canceled due to a profound lack of interest. (Note: If your birthday is in March, congratulations, you're officially the same age for another year.)
Every single infielder on the Detroit Tigers is injured on the same day, forcing the team to sign a 50-year-old - yet still surprisingly agile - newspaper columnist to play shortstop for its home opener. Sadly, that agile 50-year-old then wakes from his dream and realizes it is April Fool's Day. However, by repeatedly whacking himself on the head with an Acme mallet, said columnist is able to return to sleep in time to hit a three run homer to win the game, thus making his life complete. Not that he's wanted to be a baseball player his whole entire life or anything.)
At the Academy Awards, the Best Picture Oscar goes to "The Artist," a movie about a silent film star enjoyed by untold dozens of movie-goers. In accepting the award, director Michel Hazanavicius says, "" (See, the movie is about silent movies and so it would be out of character for him to oh, never mind.)
"None of the Above" continues to lengthen its lead for the Republican nomination, easily outdistancing the rest of the field in the Maryland, Wisconsin and Texas primaries. One voter sums up the feelings of many when she says, "To be honest, None of the Above is the only candidate not saying ridiculous things." Texas Gov. Rick Perry responds with an attack ad accusing "None of the Above" of being a "known socialist."
The NBA cancels its remaining playoff games after a grand total of 48 tickets are sold. NBA Commissioner David Stern blames the lengthy preseason lockout that forced the cancellation of the first half of the season, saying "Who knew billionaires squabbling with millionaires while half the nation is out of work would upset so many people?"
In a unanimous decision, the U.S. Supreme Court rules that Foursquare.com - where bored people tell other bored people about the boring places they're visiting in order to become the "mayor" of said locations - is a "colossal waste of time" and sentences anyone over the age of 21 who uses it to home arrest "until such time as they can find a life."
The Tea Party sues the Occupy Wall Street movement for copyright infringement, saying, "They stole our whole jiggly-eye, fringe nutwhacks thing. That's not right."
When palm trees start to grow in New Jersey, Congress is forced to admit "there might actually be something to this global warming thing."
By an unprecedented public vote, "Two and a Half Men" is canceled due to "profound unfunniness."
And finally, newspaper readers across Michigan threaten to riot when they get to the end of a column purporting to make predictions for the whole of 2012 only to find out that the guy making the predictions ran out of room and had to chop the piece in two, the second half of which will appear next week.
EDITOR'S NOTE - Andy Heller, an award-winning columnist for The Flint Journal, appears weekly in the Daily Press. He graduated from Escanaba Area High School in 1979. For more of his work, visit his blog at blog.mlive.com/flintjournal/aheller. You can e-mail him at email@example.com.


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Stream anime episodes for free, you want to Watch Bakugan Gundalian Invaders Episode 25 English Dubbed online for free. Episode guide Bakugan Gundalian Invaders Episode 25 English Dubbed Episode Description : Dragonoid Colossus Ren decideds he has had enough of Barodius' false promises and turns on him to fight by his true friends. Dharak however, chooses to let Exokor, Riptor, and Smashtor do the fighting, but eventually joins in a one on one battle against Linehalt. Meanwhile, one by one, the brawlers are taken out by the Twelve Orders. Ren takes a bad beating, so Dan decides to step in, but Linehalt and Ren ask him to stay out of the fight. Barodius begins taunting Ren, and Linehalt begins exhibiting his Forbidden Powers, to the points where they begin to tear Neathia apart.
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Strains, sequencing and assembly
The sequence and annotation for S. cerevisiae reference strain S288C was obtained from the SGD website ( http://www-genome.stanford.edu/Saccharomyces ) in May 2002. S. paradoxus strain NRRL Y-17217, S. mikatae strain IFO1815, and S. bayanus strain MCYC623 were provided by Ed Louis, Department of Genetics, University of Leicester, Leicester, UK. All species are diploid. The WGS sequence was obtained at the Center for Genome Research. We used paired-end sequencing of 4kb plasmid clones, with lab protocols as described at http://www.broad.mit.edu/. Assemblies were constructed using the Arachne whole genome assembly program. Only scaffolds that contain at least one contig longer than 2kb were kept. We used BlastN to find the best match of every read in the S. cerevisiae genome and inferred a rough correspondence between scaffolds and S.cerevisiae chromosomes. We re-ordered and oriented the scaffolds according to the corresponding chromosomal position on the S. cerevisiae genome. Supplementary information contains all contigs and scaffolds (S1a).
Determining one-to-one orthologous ORFs
For each species, we gathered the complete set of all predicted Open Reading Frames (pORFs) starting with a methionine and at least 50 amino acids long. We compared the protein sequences of these pORFs against the set of annotated protein sequences in S.cerevisiae, using WU-BLAST BlastP with parameters W=4, hitdist=60 and E=10-9. Based on the blast hits, we connected pORFs to S. cerevisiae ORFs in a bipartite graph. We weighed every edge connecting two ORFs by their average amino acid percent identity and the total length aligned in blast hits. We developed a method to automatically separate this bipartite graph into progressively smaller subgraphs until the only remaining matches connect true orthologs. To achieve this separation, we eliminated edges that are sub-optimal in a series of steps. As a pre-processing step, we eliminated all edges that are less than 80% of the maximum-weight edge both in amino acid identity and in length. This step resulted in a large number of unambiguous one-to-one matches for each of the species. Based the unambiguous matches, we built blocks of conserved gene order (synteny) when S. cerevisiae ORFs within 20kb of each other matched proximal pORFs in the assembly. These synteny blocks allowed us to resolve additional unambiguous matches, by preferentially keeping matches within synteny blocks over non-syntenic matches, and marking as paralogs the ORFs that remain orphan. We then extended the synteny blocks based on the newly resolved one-to-one matches, and resolved additional matches based on the extended blocks. We then separated the bipartite graph into its connected components, homology groups of unresolved genes. Finally, we searched for smaller homology groups that can be isolated solely based on the edge weights: we eliminated an edge between two groups when both endpoints had stronger matches to other ORFs within their respective groups. This reduced the size of the remaining homology groups, leaving unresolved mostly subtelomeric gene families for which synteny provided no resolving power. The supplementary information includes the complete correspondence between the S. cerevisiae proteins and pORFs in each of the species (S2a), the blocks of conserved synteny (S2b), and the final homology groups (S2c), dotplots visualizing the gene correspondence between each species and S. cerevisiae (S3a), and a detailed tiling of gene correspondence across the S. cerevisiae chromosomes (S3b and S3c).
Nucleotide-level alignment
We constructed nucleotide-level alignments of unambiguous regions using ClustalW. We created multiple alignments of every S. cerevisiae ORF with the orthologous pORF in each species with one-to-one correspondence. We also aligned orthologous intergenic regions when both flanking ORFs had one-to-one correspondence. When sequence gaps were present in one or multiple species, we constructed the alignment in multiple steps. We first aligned the gapless species creating a base alignment. Then we aligned each portion of a partial species onto the base alignment, and constructed a consensus for each species based on the individually aligned portions. We marked missing sequence between contigs by a dot and disagreeing overlapping contigs by N. Finally, we constructed a multiple alignment of the four species by merging the piece-wise alignments. The alignments are given in S1c and S1d. We counted transitions, transversions, insertions and deletions within these alignments (Table S4a) and used these to estimate the rate of evolutionary change between the species (Figure 3). We counted the rate of synonymous and non-synonymous substitutions for every protein coding gene (Table S4b) to find evidence of positive selection.
Genomic rearrangements
We considered consecutive unambiguous matches, marking changes in gene spacing, gene orientation, and off-synteny matches between scaffolds and orthologous S. cerevisiae chromosomes (Tables S5a). We found that changes in gene spacing are typically associated with transposon insertions and associated novel genes, as well as tandem duplications (Figure 2 and Table S5c). Virtually all changes in gene orientation typically affect between 2 and 10 consecutive ORFs and can be traced to one of 16 multi-gene inversions (Table S5b). The majority of off-synteny matches involve a single ORF and only 20 involve more than 2 consecutive ORFs. Virtually all single-gene off-synteny matches were contained within ancient duplication blocks of Saccharomyces as described in and http://acer.gen.tcd.ie/~khwolfe/yeast/nova/. These probably represent previously duplicated genes that were differentially lost in different species, rather than a DNA break in one of the two lineages, as was previously noted in . Off-synteny matches that involve more than two genes from the same chromosome correspond to one of 20 chromosomal exchanges (Figure 2 and Table S5b).
Clustering of ambiguous genes
We used ORFs with ambiguous correspondence to determine regions of rapid change in S. cerevisiae. We marked the chromosomal location of all S. cerevisiae ORFs that are ambiguous in at least one species. We then constructed ambiguity clusters when two or more ambiguous ORFs within 16kb of each other. We counted the number of ambiguities in each cluster, counting more than one ambiguities for an ORF whose correspondence was ambiguous in more than one species. Only 32 clusters were found containing more than two ambiguities (Table S5d and Figure 2). We ignored two clusters due to regions of low coverage in S. mikatae and one cluster corresponding to a previously described inversion.
Reading Frame Conservation
We evaluated reading frame conservation (RFC) for S. cerevisiae ORFs by first aligning the orthologous region for each species, then counting the percent of nucleotides in frame in the alignment, and finally casting a vote for each species and tallying the votes. For each species, we used BlastN to find a list of similar regions to the S. cerevisiae ORF in question. If the ORF lied in a synteny block, we preferentially selected the best blast hit within that block. If the ORF had no synteny information or no syntenic match, we selected the blast hit with the most nucleotide identities. We then evaluated the frame conservation within the blast alignment. We labeled each nucleotide of the first sequence by their position within a codon, as 1, 2 or 3 in order, starting at codon offset 1. We similarly labeled the nucleotides of the second sequence, but once for every start offset (1, 2, or 3). We then counted the percentage of gapless positions in the alignment that contained the same label in both aligned species, and selected the maximum percentage found in each of the three offsets of the second sequence. The final RFC value for the ORF was calculated by averaging the percentages obtained at overlapping windows of 100 nucleotides starting every 50 nucleotides. We found that the distribution of frame conservation within each species is bimodal, and we chose a simple cutoff for each species, 80% for S.paradoxus, 75% for S.mikatae and 70% for S.bayanus. If the RFC of the best hit was above the cutoff, a species voted for keeping the ORF tested. If the RFC was below the cutoff and the hit was trusted as orthologous, the species voted for rejecting the tested ORF. Finally, if no orthologous hit could be found due to coverage, a species abstained from voting. We calculated a score between -3 and +3 for every ORF based on the number of species that accepted it (+1) and the number of species that rejected it (-1). We kept all ORFs with a score of 1 or greater, and rejected all ORFs with a score of -1 or smaller. We manually inspected the remaining ORFs. We chose not to reject ORFs based on Ka/Ks ratios to avoid rejecting fast evolving ORFs. The final list of decisions for each ORF is shown in Table S6a, and the detailed results for each species are shown in Table S6b. A window-based RFC analysis for ORFs is shown in S6c.
Validating small ORFs
To evaluate the predictive power of the RFC test for small ORFs, we additionally tested for presence of in-frame stop codons in the other species. When a small ORF in S. cerevisiae showed a strong overall frame conservation, we measured the length of the longest ORF in the same orientation in each orthologous locus. We measured the percent of the S. cerevisiae length that was open in each species, and took the minimum of the three percentages (OPEN) across the three additional species. When the reading frame was open in each of the other species, the lengths found were identical to that of S. cerevisiae, and OPEN was 100%. When OPEN was below 80%, we concluded that the RFC test failed to find a true ORF conserved across all four species. Figure S3c shows the distribution of OPEN for different values of RFC. For S. cerevisiae ORFs between 50 and 100 amino acids (aa), selecting for high RFC automatically selects for high OPEN, and we estimate the test has high specificity (Figure S6d panel 1). For ORFs between 30 and 50 aa however, only a small portion of the ORFs with high RFC show a high OPEN (Figure S6d panels 2 and 3), and we conclude that the lack of indels within the small interval considered is not due to selective pressure, but instead lack of evolutionary distance between the species aligned.
Refining ORF boundaries and resequencing
We examined the multiple alignment of unambiguous ORFs to identify discrepancies in the predicted start and stop codons across the four species. We searched for the first in-frame ATG in each species and compared it to the annotated ATG in S. cerevisiae. In the S. cerevisiae start was not conserved, we automatically suggested a changed translation start if a subsequent in-frame ATG was conserved in all species and was the first in-frame ATG in at least one species. Otherwise, we manually inspected the alignment for a conserved ATG. Similarly, we suggested changes in stop codons when a common stop in all other species disagreed with the S. cerevisiae annotation. We manually inspected the alignments to confirm that the suggested start and stop boundary changes agreed with conservation boundaries. We observed a lower overall conservation as well as frame-shifting indels outside the new boundaries. We identified merges of two consecutive S. cerevisiae ORFs, when both showed protein blast hits to a single ORF in at least one other species, and when their lengths added up to the length of the matching ORF. All merges and boundary refinements suggested specific changes to the nucleotide sequence of S. cerevisiae (except 3' changes of translation start that required no change). To validate our predictions, we re-sequenced the sites of predicted sequence discrepancies. We used both forward and reverse reads in two different PCR reactions spanning the site. Supplementary information includes the primers used and the alignments of resulting reads against S. cerevisiae (S7e) and a summary of resequencing results (S7d), alignments of all predicted single-species frame-shift mutations (S7c), alignments of suggested boundary changes (S7b) and a summary of suggested start and stop refinements (S7a).
Novel introns
To identify novel introns, we searched for conserved and proximal splice donor and branch signals and manually inspected the resulting alignments. Having constructed multiple alignments of ORFs and flanking intergenic regions, we searched for conserved splicing signals. We used 10 variants of splice donor signals (6-7bp) and 8 variants of branch site signals (7bp) that are found in experimentally validated S. cerevisiae introns. We searched each species independently but required that orthologous signals appear within 10 bp from each other in the multiple alignment of the region. We also required that branch and donor be no more than 600bp apart, which is the case for 90% of known S. cerevisiae introns. We then inspected the multiple alignment surrounding the conserved signals for three properties: (1) a conserved acceptor signal, [CT]AG, 3' of the branch site (2) high RFC 5' of the donor signal and 3' of the acceptor signal. (3) low RFC within the intron. Roughly half of the conserved donor/branch pairs met our additional requirements. The remaining ones were typically internal to ORFs and could be conserved by chance alone, given the overall high nucleotide conservation in ORFs. Supplementary information contains a summary of intron revisions (S7e) and the alignments of known and predicted introns (S7f).
Motif Conservation Score
To evaluate the Motif Conservation Score (MCS) of a motif m of given length and degeneracy, we compared its conservation ratio to that of random patterns of the same length and degeneracy. We first computed the table F containing the relative frequencies of two-fold and three-fold degenerate bases, given the S. cerevisiae nucleotide frequencies (.32 for A and T, .18 for C and G). For example, W=[AT] (.32*.32) is a more likely two-fold degenerate base than Y=[CT] (.18*.32). We then selected 20 random intergenic loci in S. cerevisiae. For each of these loci, we used the order of nucleotides at that locus together with the order of degeneracy levels in m to construct a random motif. If the first character of m was two-fold degenerate and the first nucleotide at the selected locus was A, we picked a two-fold degenerate base containing A (W, R or M), their relative frequencies dictated by F, and continued for every character of m. We then counted conserved and non-conserved instances of each of the 20 selected patterns and computed r, the log-average of their conservation rates. We then counted the number of conserved and non-conserved intergenic instances of m, and computed the binomial probability p of observing the two counts, given r. We finally reported the MCS of the motif as a z-score corresponding to p, the number of standard deviations away from the mean of a normal distribution that corresponds to tail area p. We found that the majority of known motifs have a MCS of at least 4 standard deviations.
CC1: Intergenic conservation
We searched for mini-motifs that show a significant conservation in intergenic regions. For every mini-motif, we counted the number of perfectly conserved intergenic instances in all four species ic, and the total number of intergenic instances in S.cerevisiae i. We found that the two counts seem linearly related for the large majority of patterns (Figure 7a), which can be attributed to a basal level of conservation r given the total evolutionary distance that separates the four species compared. We estimated the ratio r as the log-average of non-outlier instances of ic/i within a control set of all motifs at a given gap size. We then calculated for every motif the binomial probability p of observing ic successes out of i trials, given parameter r. We assigned a z-score S to every motif corresponding to probability p. This score is positive if the motif is conserved more frequently than random, and negative if the motif is diverged more frequently than random. We found that the distribution of scores is symmetric around zero for the vast majority of motifs. The right tail of the distribution however is much further than the left tail, containing 1190 motifs more than 5 sigma away from the mean, as compared to 25 motifs for the left tail. By comparing the two counts, we estimated that 94% of these 1190 motifs are non-random in their conservation enrichment.
CC2: Intergenic-genic conservation
We searched for motifs that are preferentially conserved in intergenic regions, as compared to coding regions. In addition to ic and i (see previous section), we counted the number of conserved coding instances gc, and the number of total coding instances g, for every mini-motif. We observed the ratio of conserved instances that are intergenic a=ic/(ic+gc), and compared it to the total ratio of motif instances that are intergenic b=i/(i+g). Not surprisingly, we found that typically b=25% of all motif instances appeared in intergenic regions, which account for roughly 25% of the yeast genome. Similarly, only a=10% of conserved motif instances appeared in intergenic regions, which reflects the lower conservation of intergenic regions. To correct for this typical depletion in intergenic conservation, we estimated a correction factor f=a/b for mini-motifs of similar GC-content. Then for a given mini-motif, the proportion of all instances found in intergenic regions and the correction for the lower conservation of intergenic regions together gave us r=f*i/(i+g), the expected ratio of conserved intergenic instances for that motif. We evaluated the binomial probability p of of observing at least ic conserved instances in intergenic regions and ic+gc conserved instances overall, given the expected ratio r. As in CC1, we computed a z-score S for every motif and found a distribution centered around zero for the large majority of motifs, and a heavier right tail. We selected 1110 motifs above 5 sigma and estimated that 97% are non-random as compared to only 39 motifs below -5 sigma.
CC3: Upstream-downstream conservation
We searched for motifs that are differentially conserved in upstream regions and downstream regions. We defined upstream-only intergenic regions in divergent promoters that are upstream of both flanking ORFs, and downstream-only intergenic regions in convergent 3' terminators that are downstream of both flanking ORFs. We then counted uc and u, the conserved and total counts in upstream-only regions, and similarly dc and d in downstream-only regions. We found that upstream-only and downstream-only regions have similar conservation rates, and the ratios uc/u and dc/d are both similar to ic/i for the large majority of motifs. We thus used a simple chi-square contingency test on the four counts (uc,u,dc,d) to find motifs that are differentially conserved. We found 1089 mini-motifs with a chi-square value of 10.83 or greater, which corresponds to a p-value of .001. Given the multiple testing of 45760 mini-motifs, we estimated that roughly 46 will show such a score by chance and that 96% of the selected motifs will be non-random.
Constructing full motifs
We extended each mini-motif selected by searching for surrounding bases that are preferentially conserved when the motif is conserved. We used an iterative approach adding at every iteration one base that maximally discriminates the neighborhood of conserved motif instances from the neighborhood of non-conserved motif instances. The added base was selected from fourteen degenerate symbols of the IUB code (A, C, G, T, S, W, R, Y, M, K, B, D, H, V). When no such symbol separated the conserved and non-conserved instances with significance above 3 sigma, we terminated the extension. Figure 7D shows the top-scoring mini-motif found in CC1 (Panel 1), and the corresponding extension (Panel 2). We found that many mini-motifs have the same or similar extensions, and we grouped these based on sequence similarity. We measured the similarity between two motifs as the number of bits in common in the best ungapped alignment of the two motifs, divided by the minimum number of bits contained in either motif. Based on the pairwise motif similarity matrix, we clustered the extended motifs hierarchically, collapsing two groups if the average similarity between their member motifs was at least 70%. We then computed a consensus sequence for every cluster of extended motifs, resulting into a smaller number of mega-motifs for each test (332 for CC1, 269 for CC2 and 285 for CC3). Panel 3 shows the first 9 members of the top cluster in CC1, and the resulting mega-motif. Finally, we merged mega-motifs based on their co-occurrence in the same intergenic regions (Panel 4). We computed a hypergeometric co-occurrence score between the intergenic regions hit by each mega-motif and again collapsed these hierarchically. We computed a consensus for every cluster, and iterated the co-occurrence-based collapsing step (results not shown). We obtained fewer than 200 distinct genome-wide motifs. We found 72 consensus motifs with MCS ≥ 4 (Table 3).
Category-based motif discovery (CC4)
To select mini-motifs enriched in a given category, we counted the conserved instances within the category (IN), and the conserved instances outside the category (OUT). We estimated the ratio IN/(IN+OUT) that we should expect for the category, based on the entire population of mini-motifs. We then calculated the significance of an observed enrichment as the binomial probability of observing IN successes out of IN+OUT trials given the probability of success p. We assigned a z-score to each mini-motif, as described in the genome-wide search, and similarly extended and collapsed the significant mini-motifs.
Additional References for Methods
S1. Cherry, J. M. et al. SGD: Saccharomyces Genome Database. Nucleic Acids Res 26, 73-9 (1998).
S2. Oda, Y., Yabuki, M., Tonomura, K. & Fukunaga, M. A phylogenetic analysis of Saccharomyces species by the sequence of 18S-28S rRNA spacer regions. Yeast 13, 1243-50 (1997).
S3. Naumov, G. I., James, S. A., Naumova, E. S., Louis, E. J. & Roberts, I. N. Three new species in the Saccharomyces sensu stricto complex: Saccharomyces cariocanus, Saccharomyces kudriavzevii and Saccharomyces mikatae. Int J Syst Evol Microbiol 50 Pt 5, 1931-42 (2000).
S4. Batzoglou, S. et al. ARACHNE: a whole-genome shotgun assembler. Genome Res 12, 177-89 (2002).
S5. Jaffe, D. B. et al. Whole-genome sequence assembly for Mammalian genomes: arachne 2. Genome Res 13, 91-6 (2003).
S6. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J Mol Biol 215, 403-10 (1990).
S7. Wolfe, K. H. & Shields, D. C. Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387, 708-13 (1997).
S8. Fischer, G., Neuveglise, C., Durrens, P., Gaillardin, C. & Dujon, B. Evolution of gene order in the genomes of two related yeast species. Genome Res 11, 2009-19 (2001).
S9. Clark, T. A., Sugnet, C. W. & Ares, M., Jr. Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 296, 907-10 (2002).


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Thursday, 27 October, 2016
Stylized and colourful illustrations about politics, economy and unfortunate love. Category: Illustration
Cambridge based photographer. Photojournalism. Gallery of Ireland photographs. Documentary wedding ... Category: Photography
Tripod provides convenient, one stop shopping with a full range ... Category: Humanities\History
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Professional association of writers, photographers, and editors dedicated to redefining ... Category: Entertainment\Writers Resources
A portal for Canadian writers that offers news, places to ... Category: Entertainment\Writers Resources
A not-for-profit organization with a mission to promote the appreciation ... Category: Entertainment\Writers Resources
Tips and information about writing copy that sells. Category: Entertainment\Writers Resources
Archive of articles by Daryl Lease. Category: Entertainment\Writers Resources
Monthly article by noted SF author Gregory Benford online at ... Category: Entertainment\Writers Resources
A free online directory of almost 2,000 of the top ... Category: Entertainment\Writers Resources
Sensible solutions to get books into the hands of readers. Category: Entertainment\Writers Resources
Knowledge Hound. Links to how-to guides, tutorials and tips on ... Category: Entertainment\Writers Resources
Excerpt from pages 5-29 of Getting It Published: A Guide ... Category: Entertainment\Writers Resources
The Momaya Annual Review seeks original short stories on any ... Category: Entertainment\Writers Resources
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Unusual wood engravings, prints and drawings, created by the "little ... Category: Visual Arts\Printmaking
Linocuts and monotypes from a Seattle printmaker. Also has links ... Category: Visual Arts\Printmaking
Printmaking artist Audrey Feltham showcases original prints, printmaking methods, studio ... Category: Visual Arts\Printmaking
Australian printmaker and sculptor shows a gallery of images. Surreal ... Category: Visual Arts\Personal
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text:
I bought a lot
Binatone - Given.
Atari 2600 JR - Given
Master system 2 - Given
Mega drive - Given
The rest of it I bought
Put how your Videogame Collection come to be.
My cousin game me(and my sister)her Nes 2 Controllers and 16 games
My other Cousin gave me his Limited Edition Blue Gamegear and 7 games.
My Cousin with the nes gave me a Red Gameboy and 16 games(gave Gameboy to Friend,wrost Mistake of my life)still have the games for it
Dad brought me a Limited Edition Red Wii for Christmas
Dad brought me a PS2 Slim for Birthday
Dad got me a Red DS to replace my White DSLite
Dad found Cobalt Blue GbaSP
Dad brought me and my sister a PSone for our first System
PSone Dad Found another one at a house he was Cleaning
PS1 Dad Found at House He Was Cleaning
N64 at Thrift Store for $8.00
Gbc at Gamestore for $10.00
Gbc At Flea Market w one Game(Wario Land 3) for $8.00
1989 Gameboy at flea market for $5.00
Silver Gamecube for $5.00 at thrift store
Dreamcast $5.00 thrift store
Atari 2600 Jr and 13 games for $10.00
I bought a lot
Binatone - Given.
Atari 2600 JR - Given
Master system 2 - Given
Mega drive - Given
The rest of it I bought
Spoiler Alert!@TNightsOfGaming - My inane prattle
Your dad sounds f*** awesome!
Sig By Dprinny
Bow down, b!tch!


text:
While most players tend to dislike training camp, it is absolutely necessary heading into the season.
After an eventful summer filled with numerous offseason moves, this revamped Knicks' roster has a lot of uncertainty surrounding them.
With a rather sloppy, yet promising, exhibition game against Armani Jeans Milano out of the way, the Knicks have the next few weeks to work out the kinks as they prepare for a monumental season.


text:
A look at the teams to watch at the 2A/1A state wrestling tournament.
Culver: Culver had won a state championship six consecutive years until falling to Lowell last season. Culver took second place, but still had some impressive success. Jared Kasch became the 25th wrestler in Oregon history to win four individual titles. Kasch's success is a nod to Culver's wrestling program, which sends a high of 13 wrestlers to state 2A/1A. Monroe is the only other team to send more than 10. This Culver team has a great chance to score a ton of points. Culver also features several freshman, meaning Culver will be a team to be weary of for years to come.
Monroe: As mentioned above, Monroe sends 11 wrestlers to state including a few contenders from last season's championship. Particularly in the 113- and 170-pound weight classes, Monroe has two wrestlers with a chance to win an individual title. Expect Monroe's point total to push Culver's late into the tournament.
Lowell: Lowell won the 2013 state tournament thanks to three wrestlers winning individual titles. This season, Lowell features five of the top seeds in weight classes. Lowell has two wrestlers in the 132- and 182- pound weight classes. If any of those wrestlers catch fire, the Red Devils will have another chance to beat some of the deeper teams at state.
-- Erik C. Anderson | @ErikCAnderson


text:
Fly height control using write voltage adjustments
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text:
ART PEDROZA's GLASS HOUSE REVEALED! NUFF SAID!
Tag Archive for Noah Krom
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FactChecking recent OJ Posts on the Settlement Offer and Lawsuit
by Dan Chmielewski •
I had some high hopes that when Vern Nelson took over as editor of the Orange Juice blog he'd make an effort to make sure that some of the posts had a measure of accuracy. And I also hoped to win the $266 million lottery Tuesday, and I didn't so I'm not surprised by multiple errors and misrepresentations in three recent OJ posts about our pending lawsuit against Art Pedroza and the Orange Juice Blog.
A Letter from a Reader to Rep. John Campbell over his endorsement by Art Pedroza
by Dan Chmielewski •
We have been receiving tons of email in support of the lawsuit we filed in federal court against Art Pedroza and the Orange Juice Blog. My phone won't stop ringing with calls of support from Democrats and Republicans alike. The common theme? "Way to go." "It's about time." My business website had twice the number…
Choi uses Stalin Poster to Raise Funds for Assembly Campaign
by Dan Chmielewski •
Irvine councilmember Steven Choi is now using his Pelosi-is-Stalin stunt to raise funds for his assembly race. Choi is complaining that Democrats have attacked him for his right to free speech; no one is denying the wannabe Assemblyman his right to make a fool of himself. But this isn't the first time Choi's "free speech"…
What IS it about Blogs
by Chris Prevatt and Dan Chmielewski •
Since it's been a couple of week's since Noah Krom's passing and we've given the Krom family some time to grieve (and they will likely require more time than a couple of weeks), it's high time to address some unpleasantness in the OC blogsphere. For every spirited exchange we have with readers and other bloggers…
Beth Krom Continues Her Congressional Campaign
by Chris Prevatt •
We recieved the following release from Beth Krom's Congressional Campaign. IRVINE, CA, June 18, 2009 — In response to inquiries regarding the impact of her son's death on her Congressional race, Beth Krom has confirmed that she is fully committed to continuing her campaign to represent the 48th Congressional district. Beth and Solly remain grief-stricken…
Noah Krom's Memorial Service set for Thursday
by Dan Chmielewski •
The Krom family appreciates the outpouring of love and all the thoughtful expressions of sympathy you have extended in this time of their most intense grief. The are trying hard to make sense of this tragedy. Their hearts are broken and they know that only time and the support of their family and friends over…


text:
Excellent topic.
The important point is kids are screwed by the environment from birth, and then have to spend the rest of their life digging their way out of that whole. The only solution is to change the environment. It's not a willpower or personal choice thing, those can save an individual. But the masses are screwed, big time.
I'm in the states right now and can't believe how FAT people are, but then given the food in the environment it's what happens. Healthcare costs are going to be out of control, more so than they are already.
Annie Ups the Ante
I got lucky, I guess. I grew up in a state that's big on meat and with a father that was big on veggies. Yes, there were nasties with every meal, but there was at least balance (kinda.)
From middle school forward, I took my lunch. It was always a meat and cheese dry sandwich with lettuce and tomato, chips, soda or juice, and fruit or dessert OR leftovers. Yes, it was a sugar and carbfest, but it beat the hell out of what I saw my comrades who ate the school lunch eat.
Dinner usually had at least 3 different veggies in it, and meat, and pasta, rolls, or rice. Usually either had milk or water with it.
I never ate breakfast.
We really weren't allowed to snack. At most, we were allowed an apple or orange.
I'm 28, FWIW, and been primal for most of 3 years now.
I can't say that we're screwed, but I can't say there's an easy road ahead either. Even if you can get out of the hole, the road is filled with'em, and some of them have pit spikes at the bottom.
Life is not a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside, thoroughly used up, totally worn out, steak in one hand, chocolate in the other, yelling "Holy F***, What a Ride!"
My Latest Journal
As for the "sprinkling in pasta/rice" into my meals, I have a hard time believing the 20-30 grams of carbs we get from those is that significant and replacing with fruit/veggies. At the moment i'm just doing it on a gram-by-gram basis (aiming for 150/day max), but i suppose it's important from the perspective of "rewiring" my genes to not need carbs?
It's not about the level of carbs so much, as that tends to be an individual thing, but where those carbs come from, I'd say, yes, can be significant.
Me, My Father and The Alzheimer's - http://www.marksdailyapple.com/forum/thread84213.html


text:
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Brian Goff's Bizarre Guitars
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text:
The Nets are in a pickle. They've built a win-now team that doesn't seem to be going anywhere, and it's time to move one or more of their big names. Obviously the prize, for whatever team gets him (even if he stays on the Nets) is Jason Kidd. The consolation prize is Vince Carter, who can opt out of his contract this summer, or stay onboard for another year.
Kidd is obviously a great player, but he's not what the Knicks need and he'll come at a pretty high price for someone who's as old as he is. If you need to win a championship now before your former stars all wither away, Kidd is a good option (think about it, Miami). But if you are rebuilding, he's not the man for you - the Nets will want draft picks and young guys back for him. So that brings us to Carter, who will be significantly cheaper on the open market.
The Nets will be scared that Carter will re-sign for one last big contract in Orlando - meaning that they'll simply give up their highest scorer and get nothing in return. And there are two teams - Orlando and Charlotte - who have the space to sign him right out from under the Nets' noses. You can bet that won't happen. So they may be willing to trade him anywhere the price is right. The question is - what is that price?
Well, if he's going to be changing teams, he'll probably want to work out a sign-and-trade first, to ensure that he gets the security of a final long-term contract. So what's it worth to the Knicks to get him? 3-4 years at $16mil? More? Less? And, since the Nets would have to work out a sign-and-trade, what can the Knicks give up? Channing Frye? Jerome James? Steve Francis? Renaldo Balkman?
Personally, I see Carter as a huge risk with a moderate reward. Apparently, Isiah Thomas put Frye, James, and Malik Rose on the table at the last trade deadline, and the Nets declined. I wouldn't make that trade again anyway, knowing the position the Nets are in and the value of Rose's leadership. I think if the Knicks offer Steve Francis for Carter, straight-up, then the Nets can take it or leave it. The Knicks will take on some salary from the Nets, which sould help the Nets without hurting the Knicks, who will have four years until they'll be under the cap if they give all of their young players extensions. And the Nets will get another shot at producing with Steve Francis, who may be able to fit in next to Kidd better than he fit in next to Marbury (or, if Kidd is traded, Francis would be option #1). And if the Nets demand anything else, then they can find some other team to help them out. The worst case scenario would be for Isiah Thomas to get in another bidding war with himself, like he did in the Eddy Curry deal.
Personally, I'd be real hesitant before bringing Carter in, and if the Knicks are going to make a run at some of the other available players on the market - like Jermaine O'Neal - then they should make sure that trade happens first. Do I think the Knicks become an instant contender in the East with O'Neal and Carter? You bet I do.
But if we've learned anything from Isiah Thomas' run as Team President, it's that shortcuts to the top are often fraught with unseen trouble.