text:
It's time to re-imagine backup and recovery. Protect your business in the cloud or on premise with powerful backup software that assures recovery of your virtual, physical and cloud data, systems and applications. Experience the difference. Start your free trial today.Sponsored Listing
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OpenProj - Project Management
Open Source desktop project management5,760 weekly downloads
Liferay Portal
The world's leading open source portal30,342 weekly downloads
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A very efficient tutor.2,196 weekly downloads
Download this white paper and learn how to: Future-proof your IT and software, set your team up to easily take advantage of future technology, make your team more agile and adaptable with more time for innovation, use abstraction and automation to help manage what you have now, and integrate future technologies into your IT environment.Sponsored Listing
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professional CRM and groupware service, ready for the cloud265 weekly downloads
Analyze and visualize tours in many variations, which are recorded with a GPS device, bike-, exercise- or ergometer-computer. Some highlights: Tools are available to adjust recorded data, GPS tours can be visualized in customizable maps, ...161 weekly downloads
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As your employees increasingly use a mix of applications from the office or the road, measuring and quantifying end user experience has become nearly impossible. Endpoint Agents track performance and user experience of browser-based internal and external apps, including SaaS applications such as Salesforce and Office 365. You can even monitor virtual desktops in your environment. Sign up for a free trial to see Endpoint Agent in action.Sponsored Listing
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text:
Blowout at Allen
Kansas, fresh on the heels of a difficult loss to Oklahoma in Norman, rebounds tonight to pound Texas A&M 85-45 in Lawrence.
Kirk Hinrich led all scorers with 23 points, and fellow senior Nick Collison dropped in 15 points and 12 boards.
Keith Langford's slashing to the basket led to his scoring 18 on the evening, in part due to the care and feeding provided by Kansas guard Aaron Miles, who had his own double double tonight with 10 points and 10 assists.
For the Aggies, Morales led all scorers with 9 points, and normally-hot Bernard King managed only 7 points and 3 boards.
Wayne Simien leaves the game injured (AP Photo/Charlie Riedel)
Simien Injury Update
Sophomore Wayne Simien reinjured his shoulder just moments after entering the game in the first half, the injury coming on an attempted block of a shot by Bernard King of Texas A&M.
Simien screamed in pain and immediately was removed to the KU locker room. ESPN is reporting that Simien suffered a "subluxation" of the shoulder and, barring any further setback, should be available for Saturdays game vs. Oklahoma State.
Boxscore and Other Info
- Game recap from Yahoo! Sports.
- Boxscore from Yahoo! Sports.
- Kansas improves to 21-6 overall, and 11-2 in league play.
- KU's next game is at home Saturday vs. Oklahoma State. Gametime is 12:00 Noon. (CST).
- Discussion about this win is available at Phog Net Talk.

subset: commoncrawl


text:
Format Manuscripts/Mixed Material
Results: 1-25 of 79 | Refined by: Original Format: Manuscripts/Mixed Material Remove Subject: Indians of North America Remove Online Format: Web Pages Remove Language: English Remove
California Gold Rush collection, 1849-1900
Correspondence, travel journal, and typescripts of notes by various authors who participated in the California Gold Rush.
- Contributor: Wason, Lyman P.
William J. Ghent papers, 1876-1942
Author and journalist. Correspondence, memoranda, writings, notes, reports, subject files, photographs, clippings, and printed material relating to Ghent's writings on the West and the socialist movement in the U.S. Includes biographical sketches appearing in the Dictionary of American Biography and articles and book reviews appearing in trade journals. Also includes diaries of Edward Settle Godfrey and Holmes O. Paulding, participants in the Battle of ...
- Contributor: Ghent, William J. (william James) - Ghent, William J.
- Date: 1876
Samuel Peter Heintzelman papers, 1822-1913
Union army officer. Correspondence, diaries, journals, and military papers detailing Heintzelman's service in the United States Army from his years at the United States Military Academy through the Civil War. Includes descriptions of activities in Indian wars in Florida, the Southwest, and California, and during the Mexican War.
- Contributor: Heintzelman, Samuel Peter
- Date: 1822
Miles-Cameron families correspondence, 1661-1956
Army officer. Correspondence addressed to Elizabeth Cameron, J. D. Cameron, Nelson Appleton Miles, and Sherman Miles
- Contributor: Miles, Nelson Appleton
- Date: 1661
William Medill papers, 1834-1864
Lawyer, United States representative and governor of Ohio, and United States government official. Correspondence, account books, and miscellaneous material primarily relating to Medill's service as assistant postmaster general (1845), commissioner of Indian affairs (1845-1850), and first comptroller of the United States treasury (1857-1861).
- Contributor: Medill, William
- Date: 1834
Ebenezer Foote family papers, 1751-1871
Continental Army officer, jurist, merchant, and legislator, of Delaware County, N.Y. Family and general correspondence, orders, petitions, and legal and other papers of Foote and various members of his family. Topics include the Tammany Society of New York, the death of Alexander Hamilton, the War of 1812, the incident aboard the frigate Chesapeake, the first Seminole War, and New York politics.
- Contributor: Foote, Ebenezer
- Date: 1751
Daniel O. Drennan papers, 1775-1904
Military aide. Copies of correspondence, military dispatches, reports and other documents, as well as original letters, newspaper clippings, notes, architectural drawings, memorabilia, and printed matter collected by Drennan during his service as military secretary to Philip Henry Sheridan from 1865 to1888.
- Contributor: Drennan, Daniel O., Approximately - Drennan, Daniel O.
- Date: 1775
Clinton Presba Anderson papers, 1938-1973
U.S. senator and representative from New Mexico and secretary of agriculture. Correspondence, memoranda, speeches, hearing transcripts, reports, and other papers pertaining to Anderson's service in Congress.
- Contributor: Anderson, Clinton Presba
- Date: 1938
Philip Henry Sheridan papers,
Correspondence, letterbooks, telegrams, memoir, speeches, reports, orders, financial records, scrapbooks, and other papers relating primarily to the Civil War, Reconstruction, Mexican border disputes, Indian wars, and Sheridan's service as commanding general of the U.S. Army. Civil War material relates to cavalry operations, the Appomattox, Shenandoah, and Tullahoma campaigns, the Winchester Raid, and engagements at Boonville, Chickamauga, Missionary Ridge, Perryville, Ripley, and Stone River. Also ...
- Contributor: Sheridan, Philip Henry
Henry Clay family papers, 1732-1927
Personal, official, and family correspondence, speeches, writings, business records, legal files, biographical material, printed matter, and other papers chiefly documenting the public career and private life of statesman Henry Clay (1777-1852), United States secretary of state and representative and senator from Kentucky; his son, James B. Clay (1817-1864), diplomat, United States representative from Kentucky, and Confederate sympathizer; and other members of Henry Clay's family.
- Contributor: Clay, Henry
- Date: 1732
Gutzon Borglum papers, 1895-1960
Artist, author, and sculptor. Correspondence, diaries, family papers, subject files, speeches and writings, and other papers relating primarily to Borglum's artistic works, especially the Mount Rushmore National Memorial and plans for a Confederate memorial at Stone Mountain, Georgia. Also includes records of the Mount Rushmore National Memorial Commission and of its officials.
- Contributor: Borglum, Gutzon
- Date: 1895
La Follette family papers, 1781-1988
Family active in late nineteenth and early twentieth century national politics. Correspondence, diaries, speeches and writings, legal files, office files, campaign files, legislative files, subject files, financial records, biographical research files, newspaper clippings, printed matter, and miscellany principally documenting the careers of Robert M. La Follette (1855-1925), governor of Wisconsin and United States representative and senator, and his son Robert M. La Follette (1895-1953), ...
- Date: 1781
Sumner family papers, 1836-1940
Correspondence, legal documents, reports, and photographs of Edwin V. Sumner (1797-1863) and his sons, Edwin Vose Sumner (1835-1912) and Samuel Storrow Sumner (1842-1937), all military officers.
- Date: 1836
Archivo Nacional de Cuba collection pertaining to Spanish colonial rule in Louisiana and the Floridas, 1770-1911
Transcripts of material found in the Cuban national archives pertaining to Spanish colonial rule in Louisiana and the Floridas. Includes correspondence of the Spanish governor of Louisiana, Bernardo de Gálvez, correspondence of British traders operating under Spanish protection, in particular William Panton, material concerning commerce and political relations with the local Indian tribes, Spain's part in the American revolution and relations with the newly ...
- Contributor: Archivo Nacional De Cuba
- Date: 1770
Solon Hannibal Borglum papers, 1886-1969
Sculptor. Correspondence, commission files, subject files, articles, certificates and awards, photographs, printed matter, a scrapbook, and microfilm mostly relating to Borglum's career as a sculptor, his works of art, and his activities with the American Expeditionary Forces Art Training Center in Bellevue, France, Silvermine Group of Artists in New Canaan, Connecticut, and the School of American Sculpture in New York.
- Contributor: Borglum, Solon Hannibal
- Date: 1886
Beale family papers from the Decatur House, 1794-1957
Correspondence, journals, biographical material, speeches, articles, scrapbooks, printed material, and other papers pertaining to the role of Edward Fitzgerald Beale in opening the West; the diplomatic career of Truxtun Beale as United States minister to Greece, Persia, and Romania; the naval careers of Thomas Truxtun and Stephen Decatur; the Beale (Beal), Chase, Edwards, and Truxtun families; and the Decatur House.
- Date: 1794
Martin Van Buren papers,
Correspondence, speeches, messages to Congress, writings, notes, legal record book, estate record book, autobiographical material, and other papers pertaining to slavery and the antislavery movement; banking and the Second Bank of the United States; party politics in New York state and at the national level relating to the Federalist, National Republican, Whig, and Democratic parties, particularly during the Jackson and Van Buren administrations; and ...
- Contributor: Van Buren, Martin - Van Buren, John
Voices of Civil Rights
The events of the U.S. Civil Rights Movement are documented through personal stories, oral histories, and photographs collected by the "Voices of Civil Rights" project, and marks the arrival of these materials to the Library.
- Contributor: Adams, Victoria Gray - Andrade, Juan - Baxley, Bill (william Joseph) - Beal, Gerald K. - Beerman, Leonard I. - Boggs, Grace Lee - Bonilla, Rubén - Booth, Heather - Bourne, St. Clair - Branch, Raylawni G. ... Adams, Victoria Gray - Andrade, Juan - Baxley, Bill (william Joseph) - Beal, Gerald K. - Beerman, Leonard I. - Boggs, Grace Lee - Bonilla, Rubén - Booth, Heather - Bourne, St. Clair - Branch, Raylawni G. - Braxton, Annye H. - Brownmiller, Susan - Carlos, John - Charles, Michael Ray - Collins, Wendell - Dahmer, Ellie J. - Davis, L. Clifford - Dickinson, James Luther - Dinkins, David N. - Doty, Juanita Sims - Epps, Jesse - Fife, John M. (john Macmillan) - Fleming, Karl - Forman, James - Fountain, Clarence - Frank, Barney - Garcia, Isabel (isabel G.) - Gields, Clarence - Goodman, Carolyn - Graves, Curtis - Green, Percy - Gutiérrez, José Angel - Hackney, Lucy D. - Halpern, Rosario Salgado - Harjo, Suzan Shown - Harrington, Penny - Hayes, Shirley G. - Height, Dorothy I. (dorothy Irene) - Hill, Oliver W. - Hite, Nancy - Holland, Endesha Ida Mae - Hooks, Benjamin L. (benjamin Lawson) - Horowitz, Rachelle - Jarrett, Vernon - Jones, Doug (g. Douglas) - King - Kirk, Ron - Kochiyama, Yuri - Kwoh, Stewart - Kyles, Samuel Billy - Landrieu, Moon - Lawson, James M. - Lee, Helen Shores - Lee, Sammy - Lewis, John - Little Joe - Lout, Mike (james M.) - Lowery, Joseph E. - Lyons, Kenneth O. - Mashariki, Job - McKinstry, Carolyn Maull - McWhorter, Diane - Mease, Quentin R. - Meier, Deborah - Mingo, Lucy - Monroe, Sputnik - Moses, Robert Parris - Moutoussamy-Ashe, Jeanne - Murray, Tawanda - Norton, Eleanor Holmes - Oldham, Charles R. - Poussaint, Alvin F. - Pride, Carlton - Reid, Vernon - Rivers, Eugene - Romilly, Constancia - Rowles, Billy E. - Seay, Norman R. - Sellers, Cleveland - Shores, Barbara - Sims, Bernice Banks - Smith, Jerome M. - Spellman, Toyin - Steger, Michelle - Sutton, Goodloe - Swann-Daniels, Carol - Tafel, Richard - Thompson, Larry Dean - Tisdale, Alice - Tisdale, Charles - Trickey, Minnijean Brown - Uyeshima, Erin Emiko - West, W. Richard - Wilder, Lawrence Douglas - Wilkins, Roger W. - Wilson, Diane - Wilson, Edwin O. - Wunrow, Jeffrey D. - Yamamoto, Joyce C. - Zabel, William D. - Bowley, Andy - Briggs, Jimmie - Hargrove, Earnestine - Iverem, Esther - Kellogg, Alex - Krol, Debra Utacia - Latimer, Leah Y. - Lewis, Dan - Lum, Lydia - Mapp, Marilyn - Marquez Stathis, Sandra - Miller, Tom - Neubauer, Rita - O'konis, Jonathan - Patoski, Joe Nick - Pierce, Ponchitta Anne - Reavis, Dick J. - Rosenfeld, Megan - Rosenzweig, Hannah - Sloan, Lester - Smith, Vern E. - Whitehouse, Liz - Wolf, Bonny - Ynclan, Nery - Williams, Juan - Aarp (organization) - Library of Congress - History Channel (television Network) - Leadership Conference on Civil Rights
- Date: 2005-02-24
Andrew Jackson papers,
Correspondence, memoranda, journals, speeches, military papers, land deeds, scrapbook, printed matter, and other papers reflecting most phases of Jackson's military and political career. Subjects include his law practice in Tennessee, his service in the U.S. Congress; Florida and Tennessee state politics; the War of 1812; Creek War, 1813-1814; Battle of New Orleans, 1815; Indian affairs; Eaton Affair (Petticoat Affair) involving John Henry Eaton and ...
- Contributor: Jackson, Andrew
Clinton family papers, 1776-1806
Army officer, governor of New York, and public officials. Chiefly correspondence (mainly transcripts and drafts) of George Clinton and James Clinton relating to military engagements during the Revolution, drafting of the Articles of Confederation by the Continental Congress, and land transactions in New York; orderly book of James Clinton containing orders given during the expedition against the Iroquois; and various commissions, land grants, and ...
- Date: 1776
Thomas Henry Carter papers, 1883-1917
Lawyer and United States representative and senator from Montana. Correspondence, writings, memoranda, clippings, notes, invitations, photographs, and financial records relating primarily to Montana, Republican Party politics, and Carter's career in Congress.
- Contributor: Carter, Thomas Henry
- Date: 1833
John Spalding Flannery papers, 1902-1953
Lawyer. Chiefly records from McKenney, Flannery & Craighill, the Washington, D.C. law firm in which Flannery was a principal partner.
- Contributor: Flannery, John Spalding
- Date: 1902
Levi Woodbury family papers, 1638-1914
Correspondence, diaries, speeches and writings, financial and legal papers, genealogical notes, autograph collections, scrapbooks, clippings, and other papers chiefly of Levi Woodbury and also of his son, Charles Levi Woodbury, and other family members.
- Contributor: Woodbury, Levi
- Date: 1638
Josiah Bartlett family papers, 1710-1931
Statesmen and physicians. Correspondence, diaries, diplomas, legal and financial records, notebooks, account books, speeches, genealogical material, printed matter, and newspaper clippings documenting the Bartlett family's professional and political activity in New England in the seventeenth, eighteenth, and nineteenth centuries. Topics include New England's sentiment towards the War of 1812 as well as American political life before and during the Civil War and post Civil ...
- Contributor: Bartlett, Josiah
- Date: 1710
Henry Rowe Schoolcraft papers, 1788-1941
Author, ethnologist, explorer, geologist, glass manufacturer, and Indian agent. Correspondence, journals, articles, books, manuscripts of magazines, poetry, speeches, government reports, Indian vocabularies, maps, drawings, and other papers reflecting Schoolcraft's career as a glass manufacturer, mineralogist on an exploring expedition in the Ozark Mountains, geologist on the Cass expedition to the Northwest Territory, leader of expeditions throughout the Great Lakes region, member of Michigan's legislative ...
- Contributor: Schoolcraft, Henry Rowe
- Date: 1788


text:
Explore 1959 Vintage, Vintage Advert and more!
Suzy Parker and Jean Patchett wearing dresses by Kay Windsor, 1959.
Alice Bruno wearing a dress by Nelly Don 1954
Model wearing dress by Pattullo - Jo Copeland 1958
1967, Elle
1971 4
Mod 60s dress
1970's. Fashion
Balenciaga 1955 Evening Dress Cartier Jewels


text:
Latest News Almost three years after it kicked offits services, Grofers ,the online grocery delivery startup has ditched its application only... ...http://thetechportal.com/2016/10/23/grofers-website-ditches-just-app/
While, ICICI Bank and Axis Bank together got about $450 million, Standard Chartered Bank was paid $2.1 billion. Employees walk past an Essar... ...http://www.ibtimes.co.in/essar-repays-loans-icici-bank-axis-bank-standard-chartered-bank-700863
Sony in partnership with eSports company ESL to launch a new tournament feature for its PlayStation 4 console Sony has partnered with eSports... ...http://indianexpress.com/article/technology/gaming/sony-introduces-tournaments-feature-for-ps4-games-3098264/
Hey there! I wanted to write about this for a long time but just could not summarise this brilliant newsletter. Frankly I didn't know what to... ...http://economictimes.indiatimes.com/markets/stocks/news/ritesh-jains-what-i-read-this-week-why-a-15-yr-old-hedge-fund-shut-shop-apparel-to-indias-rescue-on-jobs-front/articleshow/54992153.cms
AT&T on Sunday revealed Capex (capital expenditure) benefits from the $85.4 billion deal to acquire media giant Time Warner in a bid to become a... ...http://www.telecomlead.com/telecom-services/att-reveals-capex-benefits-from-85-bn-time-warner-deal-72093
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text:
I know that most experienced hubbers are well past this little milestone, but this is my first. I have been on Hubpages almost a month now and I think I am going to reach 1,000 views today. Celebrate with me!
Thats a wonderful milestone. keep it up!
Congratulations! I just read one of your hubs to inch you closer.
Congrats... that certainly beats visiting the flowers doesn't it?
congrats! The first of manyI hope!
Congrats! I just stopped by and viewed one of your hubs to get you one closer! Enjoyed finding out that someone makes a cologne that smells like "dirt"
Thank you for visiting! And yes, dirt is now a perfume smell. So as tomatoes, salad, snow, thunderstorm and rain.
Reached my goal of 1,000 viewers a couple of hours ago! Yey! Thank you, all visitors. (Please, please, please, come again.)
Congratulations on reaching your goal; now set another one, quick! I hopped over to check out your hubs, and I loved the one on making the flower pins. I've got some broken necklaces that I can repurpose with your wonderful instructions:)
"repurpose" is that really a word?
Every milestone is important. one leads to another. Congratulations!
Congratulations, Queen Bumble Bee! I'm happy for you and will definitely celebrate with you. Here's to your 1,000 milestone... Cheers!
THANK you, thank you!
Very excited for you wonder feeling isn't it. Just think of the day when you get 1000 views in a day! It will happen, you just watch. Now I must go check your hubs out......
by Jean Bakula3 days ago
I'm so psyched, it took so long. I think I'll take a screen shot and frame it!
by Carolee Samuda12 months ago
I want to thank Hubpages for allowing me to publish here. You were my first love for publishing online. I still haven't found another lover like you and can't seem to let you go. With all the arguments and disagreements...
by Donna Campbell Smith6 years ago
But I did it! Now I have the audacity to believe someday I'll reach 1,000,000.
by rebekahELLE4 years ago
I usually don't post milestones in the forum, but wanted to share this one with you. Hopefully it will encourage others.I reached 100,000 views sometime in Sept or Oct., 2011 Yesterday or very early this morning I...
by SpaceShanty21 months ago
I have just earned by 100,000 views accolade here on Hubpages after just 20 months!I don't want to just brag, but no one else I know outside of Hubpages would appreciate the significance!
by Janis Leslie Evans2 years ago
Woop, woop . . . I hit another milestone today, 100,000 views to my hubs. Yeaaay! I'm grateful to all of my fellow hubbers who read and share my hubs. But I'm eternally grateful to those who come by way of organic...
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text:
50cc motorcycle EEC certificated
Engine :50cc Single cylinder,4 strokes, air coolingBore * Stroke: 39.0 * 41.5Compression Ratio: 10.5:1Rated Power: 2.1/7500kW(r/min)Ignition: C.D.IStarting Mode: Electric startingWheel Base: 1340mmClutch: Dry tape,automatic,centrifugalFront Tire: 90/90-12Rear Tire: 4.8-8Front brake: Drum/ hand controlRear brake: Drum hand controlMax. Speed: 50km/hMax. Load: 180kgFuel Tank: 4.5LProduct size:1840 x 960 x 1790mm
Sales Terms & Specifications:
|Model No.
|Place Of Origin
|Price Terms
|FOB / CIF / EXW(Factory Price)
|Terms Of Payment
|T/T, Western Union, PayPal, L/C at sight
Relative Products
2005 Harley-Davidson: Sportster 8832005 XL 883L. Excellent condition! No nicks or scatches! Adult ridden. Wifes bike. Many extras include; Vance & Hines Pipes, hi
Dirt BikeColor: black, silver, red, green Engine type: 49cc, single cylinder, air-cooling, 2-stroke Tyre (F/R): 2.50-12/18 x 9.5-8 Brake
160cc Snowmobile1) Standard track with slider 2) Four stroke engine: 160cc 3) Front and rear suspension 4) Tether cord 5) Lightweight 6) Drive
Motorcycle (LX110PY-CL)Specifications: 1) Engine type: 4-strokes, air cooled 2) Cylinder arrangement: single cylinder 3) Bore x stroke: 52.4 x 49.5mm 4
MotorcycleSize (L x W x H) (mm): 2,145 x 770 x 1,135 Wheel base (mm): 1485±15 Ground clearance (mm): 150±15 Top speed (km/
125cc Off-Road Dirt Bike (New Design with Swing Arm)Specifications: 1) Vehicle: a) Dimensions (L x W x H): 1,665 x 780 x 1,050mm b) Wheelbase: 1,175mm c) Min. ground cle
BMW K 1200 S MotorcyclesThe K 1200 S was designed as a sport bike and is a completely separate motorcycle within the K family. It is radically new, feat
CubDimensions (L*B*H) (mm): 1920*715*1100 Wheel base (mm): 1220 Min. Ground Clearance (mm): 150 Dry Weight: 96kg Height Of Seat (mm
110cc Moped MotorbikeSpecifications: 1) Dimensions (L x W x H): 1940 x 695 x 1085mm 2) Wheel base: 1250mm 3) Max. speed: ≥ 85km/h 4) Start meth
MotorcycleOverall size (L x W x H): 2,020 x 740 x 1,130mm Max. speed (km/h): 85 Max. loading (kg): 150 Brake type: FR/disc, RR/drum
125 Cc Motorcycle (Soncap)Detailed Product Description 1) Dimensions (mm) : 1, 945 x 740 x 1, 110 2) Maximum load capacity (KG) : 150 3) Maximum power: 7.
Scooter with E-MarkFeatures: 1) Dimensions (L x W x H): 1,891 x 872 x 1,090mm 2) Axle distance: 1,255mm 3) Ground clearance: 108mm 4) Max. speed: 9


text:
Miami's World Series MVP: A-Rod
As far as I know, there were two Miami boyz playing in the World Series -- A-Rod (Westminster) and Raul Ibanez (Sunset) -- as well as a lot of Dominicans and others who spend significant time here.
Though Hideki Matsui won the MVP -- and he's a Yankee I generally don't despise -- I crown A-Rod our top guy en la seria mundial. I mean, he's the team leader and started like crap but came on like a pile driver. He batted far under .200 for much of the series, but hustled -- even stole a base in the final game -- and was patient. He scored five runs, several off of walks, and his slugging percentage in the end was a respectable.550, the best on the Yankees.
The Phillies' Ibanez's numbers look better. He batted over .300 with an impressive four doubles and his slugging percentage was better, .609. But, the dude only scored two runs. When it mattered, he flopped. Shane Victorino, who missed an important catch, may be the goat of this series, but Ibanez's play was forgettable.
I just wish Hanley had been there. That kid deserves a ring!
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Again, whether you fully believe Donaghy or not, he does provide a fascinating perspective into the world of refereeing that simply no one else can provide.


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Designing boxes - repost
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Check in from 12h / Check out prior to 12h
Mara House Hotel Luxor: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Luxor, Egypt.
Situated under a 20-minute stroll from Luxor Railway Station, Mara House Hotel provides guests with a convenient base when visiting Luxor.
Hotel description
A satisfying breakfast is available every morning at Mara House Hotel Luxor, and there are numerous restaurants and cafés close by. Drinks can be enjoyed at the on-site bar. There is also the added convenience of an in-house restaurant.
The hotel provides a convenient base to explore Valley of the Kings, as well as everything the local area has to offer. The Karnak Temple Complex and Luxor Temple are in close proximity to the property.
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- 17th annual Platinum Judging begins todayPosted 16 hours ago
- Inside Walla Walla's Artifex: More than a custom-crush facilityPosted 2 days ago
- Climate change presents possibilities, challenges for Washington wine industryPosted 3 days ago
- Cabernet Sauvignon is king in WashingtonPosted 4 days ago
- Woodinville WineCraft auction moves to Columbia WineryPosted 5 days ago
- Washington wine growers, irrigators grapple with climate changePosted 6 days ago
- Walla Walla's Doubleback making its own identityPosted 7 days ago
- Charles Smith reshapes Washington wine industryPosted 1 week ago
- Judges select favorites at Great Northwest Invitational Wine CompetitionPosted 1 week ago
- Commentary: Why the lack of women winemakers in Washington?Posted 1 week ago
- This event has passed.
International Pinot Noir Conference
July 29 - July 31$125
Event Navigation
MCMINNVILLE, Ore. – The wine world will descend July 29-31 upon Oregon's Yamhill County for the 2016 International Pinot Noir Celebration, with more than 70 wineries pouring and 60 chefs providing Northwest-focused cuisine.
The three-day event celebrates its 30th anniversary and takes place at Linfield College in the heart of Oregon wine country. It features two large tastings, multiple seminars, the annual Salmon Bake and vineyard tours.
Tickets for the entire weekend are $1,200. Events also can be purchased a la carte: The Salmon Bake is $225, and the Sunday Passport to Pinot is $125.
While IPNC takes place in Oregon Pinot Noir country, wines from around the globe will be featured.
From North America, wineries from Oregon, Washington, California, Michigan, Virginia and British Columbia will be pouring. From Europe, winemakers from Pinot Noir's ancestral home – Burgundy – will be well represented. But a German winemaker also will be pouring.
And Southern Hemisphere winemakers from New Zealand, Australia and Argentina also will share their examples of Pinot Noir.
Oregon wineries at IPNC
The most-represented region will be Oregon. The wineries featured at this year's IPNC include: Alexana Estate Vineyards & Winery, Newberg; Anam Cara Cellars, Newberg; Archery Summit, Dayton; Ayres Vineyard, Newberg; Bergstrom Wines, Newberg; Brick House Wine Co., Newberg; Brittan Vineyards, McMinnville; Chehalem Wines, Newberg; Colene Clemens, Newberg; Cristom Vineyards, Salem; Domaine Drouhin Roserock, Dundee; Domaine Serene, Dayton; Elk Cove Vineyards, Gaston; Foris Vineyards Winery, Cave Junction; Harper Voit, Gaston; J. Christopher Wines, Newberg; J.K. Carriere, Newberg; Johan Vineyards, Rickreall; La Crema Winery, Willamette Valley; Lange Estate Winery, Dundee; Lazy River Vineyard, Yamhill; Owen Roe, Newberg; Panther Creek Cellars, Dundee; R. Stuart & Co., McMinnville; Rex Hill, Newberg; Shea Wine Cellars, Newberg; Sineann, St. Paul; Sokol Blosser, Dundee; Solena Estate, Yamhill; St. Innocent Winery, Salem; Tendril Wine Cellars, Gaston; Trisaetum, Newberg; Walter Scott Wines, Salem; Winderlea Vineyard & Winery, Dundee, and Witness Tree Vineyard, Salem.
Wineries are selected through a tasting process and must compete for the opportunity to represent their regions.
Overall, more than 250 wines will be poured throughout IPNC weekend.
IPNC itinerary
Here is a look at this year's IPNC:
Friday, July 29
- 7:30-9 a.m.: Breakfast on the patio.
- 9:15 a.m.-3 p.m.: Vineyard tour and winery lunch.
- 3:30-5 p.m.: Afternoon activities such as special tastings and book signings.
- 5-7 p.m.: Alfresco tasting, in which 35 winemakers pour their featured Pinot Noirs.
- 7:30-11 p.m.: Grand dinner includes wines from the IPNC wine library and cuisine from featured Northwest chefs.
Saturday, July 30
- 7:30-9 a.m.: Breakfast on the patio
- 9:30-11 am.: Grand seminar, a large-format seminar and tasting from some of the most influential people in Pinot Noir.
- 11:30 a.m.-1:30 p.m.: Lunch on the lawn.
- 2-3:30 p.m.: University of Pinot. Various seminars focus on different aspects of Pinot Noir, from geology, history, chemistry and geography.
- 3:30-5 p.m.: Afternoon activities.
- 5-7 p.m.: Alfresco tasting, in which 35 winemakers pour featured Pinot Noirs.
- 7:30-11:30 p.m.: Northwest Salmon Bake. This is one of the signature events of IPNC, during which wild salmon is roasted on stakes over a fire pit.
Sunday, July 31
- 10 a.m.-noon: Sparkling brunch.
- 2-6 p.m.: Passport to Pinot. More than 70 wineries from around the world will pour Pinot Noirs, accompanied by cuisine from Northwest chefs.


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Critiquing USA Today's Anti-Trump Editorial
Last Thursday, USA Today's editorial board published a scathing denunciation of Donald Trump, declaring him to be "unfit for the presidency" and urging voters not to cast their ballot for the Republican presidential nominee. However, some of the condemnations issued by the editorial board could also be levied against Democrat presidential candidate Hillary Clinton. The […]Continue Reading


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Question regarding how good one should be...
View Single Post
31st July 2013, 03:07 PM
Senior Member
Join Date: Nov 2008
Location: Isle of Wight
Posts: 614
Originally Posted by
OK, so i have a general question
If a person is considered a good FT shooter, what kind of results should that person have when training?
Say, when shooting on paper at 50m , what should be my ctc to consider myself a good shooter?
If you don't mind, post your general score, so that i can get some kind of reference to which to grade myself...
I hope you understand what i'm getting at...
It is very difficult to know what your standard of shooting is in relation to others when by yourself. I, for a while, was practising by myself with no one else to gauge my level of shooting.
With that in mind, I think it may be an idea of setting up a training course of targets to practise with. I, like Simon (NJR100) try to get a number of shots within a 25mm disc at 45yd (40m) and then repeat it at 55yds(50m) before going on to shoot our FT course.
Bench resting your rifle in still conditions will allow you to understand your groups at the various distances. For example, I would expect up to lets say 30m all pellets benchrested should be within a group size of no greater than 15mm. Up to 50m no greater than 25mm. This I would think would be the minimum standard of rifle and pellet combination. Pellets are a fickle thing as the same make will have differences which can throw pellets anywhere or just the occasional flyer.
Not sure what the kill zone sizes are in your country but those above are based on ours in the UK.
Thinking about it a little bit I think practising on known distance targets will get you happy with your rifle set up. It is very rare that you will have targets that are in 'standard' locations as every course designer/lay out will be different. Practising on level ground and flat targets will build confidence but when you have uneven ground and targets higher and lower that you, the better you will be able to compensate and understand your set up.
I have found that when shooting a course and 'see' my misses I mark on the score card a small dot where I miss. When the course is finished I take a photo of the card for reference and then use it to see if I can understand why I missed. Simon does this and it is his idea that I have pinched
You know how many targets you will normally knock down, think of that as the bench mark and you have to hit more than that each time. Once constantly you can hit lets say 20/40 then raise the number to 22. Only when you have been able to hit a minimum of 22 for a number of practise days in different conditions and days can you increase it.
Our practise course is 20 targets, my minimum is currently 14 and for the last few weeks I have been around or lower than that. Some of the targets get moved every other week so the course is not always the same. My let downs are standers which I am practising more as I have difficulty in kneeling at the moment. On a current GP course that means I take 10 shots standing and with my 50% record I know I will lose 5 shots before I even start.
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$GD said the total value of the five-ship contract is about $3.4Bil. There are currently four DDG 51 destroyers in production at Bath Iron Works: Rafael Peralta (DDG 115), Thomas Hudner (DDG 116), Daniel Inouye (DDG 118) and Carl M. Levin (DDG 120).
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|Road Name:
|Birch Close
|Road Type:
Birch Close is a street in the settlement of Hexham governed by Hexham Civil Parish council in the administration area of Northumberland Council located in the North East Euro Region of the UK.
Birch Close is located 253.56 miles North from the centre of London, 20.32 miles West from the centre of Newcastle upon Tyne, 32.7 miles East from the centre of Carlisle and 68.91 miles North East from the centre of Lancaster.
Birch Close is approximately 12.26 miles from the coastal tidal high water mark) and is 148 metres above sea level
Postcodes for Birch Close
|The Central point of Birch Close is approximately 148 Metres above sea level
Hotel information updated 09/10/2016
|Low West - hexham
|Located 33 km from Newcastle upon Tyne and 41 km from Durham, Low West offers pet-friendly accommodation in Hexham. The property is 48 km from Sunderland and free private parking is featured.
|, NE46, Hexham
|Number of Rooms:
|Lowest Price Room:
|Snooty Fox Cottage - hexham
|Snooty Fox Cottage is a holiday home set in Hexham, 32 km from Newcastle upon Tyne. The property is 40 km from Durham and features views of the city. Free WiFi is provided throughout the property. The kitchen features a dishwasher. A TV is offered.
|, NE46 2JT, near Hexham
|Number of Rooms:
|Lowest Price Room:
|Best Western Beaumont Hotel - hexham
|Star Rating:
|3 Stars
|Best Western Beaumont Hotel is situated in the heart of the market town of Hexham, less than 10 minutes
|Beaumont Street, Hexham, Northumberland, NE46 3LT, Hexham
|Number of Rooms:
|Lowest Price Room:
|The County Hotel - hexham
|The County Hotel offers pet-friendly accommodation in Hexham. Guests can enjoy the on-site bar. The rooms include a flat-screen TV. Extras include free toiletries and a hairdryer. The County Hotel features free WiFi .
|Priestpopple, NE46 1PS, Hexham
|Number of Rooms:
|Lowest Price Room:
|Station Inn - hexham
|A 2-minute walk from the train, Station Inn in Hexham offers bed and breakfast close to the town centre. With a restaurant and bar, Station Inn serves a full English breakfasts, and rooms have free WiFi. Each room has an en suite shower.
|Station Road, NE46 1EZ, Hexham
|Number of Rooms:
|Lowest Price Room:
Local Council Details
|Within the area of Northumberland
|Visit the Council's Website
|County Hall
|Send Mail
|Telephone Number: 0845 600 6400
|Within the electoral area of Not Found -
|Within the Westminster Parliamentary Constituency of Hexham
|The Member of Parliament is Opperman, Guy
|Within the area of Hexham Civil Parish Council
Water and Drainage Details
|Northumbrian Water
|Visit Northumbrian Water's Website
Recent House Sales in Birch Close
|2 Birch Close
|Sale Price: £245,000
|Sale Date: 18/03/2016
|6 Birch Close
|Sale Price: £167,500
|Sale Date: 12/07/2000
|Source: Land Registry Price Paid Data accessed via API
Population Statistics
|ONS Area Code: E01027491
|Ons Area Name:Northumberland 035D
|Average Age : 48.23
|Population: 1608.00
|Male Population: 775.00 (48.2%)
|Female Population: 833.00 (51.8%)
|Number Claiming Benefits: 11 (0.68%)
|Source: Office of National Statistics 2011 Census Data
Neighbourhood Policing
|Police Force:
|Find a Local Neighbourhood Watch Scheme
|Visit Police Website
|Visit Police Facebook Page
|Email Police
|Telephone: 01282 472107 (voicem
|Policing Links:
Recent Crime in the Area
|Source: data.police.uk accessed via API
Map of Crimes Committed Near Birch Close
Random Street
Roman Close
Location Details
Birch Close
|OS Reference: 392202, 563260
OS Grid Reference: NY922633
|Latitude and Longitude: 54.963831717371, -2.121805964296
|Approximate distance to the Coast: 12.26 miles
Ordnance Survey Landranger Map Series for Birch Close
|Map Number: 87
|Map Name: Hexham & Haltwistle
|Beaumont Park
|North East
Nearest Railway Stations
|Hexham Rail Station is 2.11 Kilometers away (1.31 miles)
|Corbridge Rail Station is 6.72 Kilometers away (4.18 miles)
|Haydon Bridge Rail Station is 8.05 Kilometers away (5 miles)
|Riding Mill Rail Station is 9.86 Kilometers away (6.13 miles)
Nearest Airports
|Newcastle International Airport is 27.69 Kilometers away
|Durham Tees Valley Airport is 67.19 Kilometers away
Nearest Ferries
|Tower Knowe Ferry Landing is 32.59 Kilometers away
|Belvedere Ferry Landing is 34.63 Kilometers away
|Leaplish Ferry Landing is 35.93 Kilometers away
|Newcastle International Ferry Terminal is 43.25 Kilometers away
Nearest Motorway or Major Trunk Road
|Birch Close is approximately 1.50 miles from the A69
Nearest Motorway Junctions
|Junction: A1(M) J65/A194(M)/A1(T)/A1231/B1288 - 36.82 Km Away
|Junction: A1(M) J64/A195 - 37.19 Km Away
|Junction: A1(M) J63/A167/A183 - 37.45 Km Away
Health Clinics
|Burn Brae Medical Group
|Hexham Primary Care Ctr, Corbridge Road, Hexham, Northumberland, NE461QJ
|Distance: 1.89 Kilometers
|Telephone: 01434 603627
|The Sele Medical Practice
|Hexham Primary Care Ctr, Corbridge Road, Hexham, Northumberland, NE461QJ
|Distance: 1.89 Kilometers
|Telephone: 01434 602237
|The Fairington Centre
|The Fairington Centre, Corbridge Road, Hexham, Northumberland, NE46 1QJ
|Distance: 1.89 Kilometers
|Telephone: 01434 656220
|Corbridge Health Centre
|Corbridge Health Centre, Newcastle Road, Corbridge, Northumberland, NE455LG
|Distance: 7.17 Kilometers
|Telephone: 01434 632011
Nearest Libraries
Hexham Library
|Queens Hall Arts Centre, Hexham, NE463LS
|Distance: 0.93 Miles
|Visit Website
Corbridge Library
|Hill Street, Corbridge, NE455AA
|Distance: 4.23 Miles
|Visit Website
Haydon Bridge Library
|Church Street, Hexham, NE476JQ
|Distance: 4.97 Miles
|Visit Website
Nearest Tourist Attractions
|Attraction Name: The Old Gaol
|Distance: 1.11 (km)
|Attraction Name: Hexham Racecourse
|Distance: 1.29 (km)
Historic Place of Worship
|Attraction Name: Hexham Abbey
|Distance: 1.49 (km)
Country Park
|Attraction Name: Tyne Green
|Distance: 2.28 (km)
Nearest Schools
St Joseph's Roman Catholic Voluntary Aided Middle School
|Distance: 0.67 Kilometers
|Type: Middle Deemed Secondary
|Address: Highford Lane, Hexham, Northumberland, NE46 2DD
|Telephone: (01434) 605124
Queen Elizabeth High School
|Distance: 0.78 Kilometers
|Type: Secondary
|Address: Whetstone Bridge Road, Hexham, Northumberland, NE46 3JB
|Telephone: (01434) 610300
St Mary's Roman Catholic Voluntary Aided First School
|Distance: 1.28 Kilometers
|Type: Primary
|Address: Hencotes, Hexham, Northumberland, NE46 2EE
|Telephone: (01434) 603791
The Sele First School
|Distance: 1.49 Kilometers
|Type: Primary
|Address: The Sele, Hexham, Northumberland, NE46 3QZ
|Telephone: (01434) 602808
Broadband Speed (megabits per second)
|Speed: Greater than 2 Mbps
|Average Speed: 10.7
|Median Speed: 7.5
|Maximum Speed: >=30
|Next-generation access (NGA)?: Y
|Number of Connections: 7


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- October 21: Cadillac CT6 Recalled to Replace Missing Bolts recalls | 6 days ago
- September 17: GM Says Takata Airbag Recall of 980,000 Vehicles is Unnecessary news | 40 days ago
1997 Cadillac Catera
seat belts / air bags Problems
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Vegan spot Raw Vegan Cafe, located in Lockport, is perfect for the meat and dairy-free crowd. Eating right doesn't have to be hard. Head to Raw Vegan Cafe for a healthy or gluten-free meal. Youngsters don't need to sit out a trip to this restaurant ? it's super family-friendly and perfect for little diners and their folks. Warm weather brings out Raw Vegan Cafe's highly coveted patio seating. Wifi here is on the house. Have a large group? No problem. Head to Raw Vegan Cafe for easy seating.
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Meet SAP at Mobile World Congress
If you are looking to take advantage of the growing enterprise mobile app market in 2014, SAP has a great opportunity for you.
We are excited to introduce you to a new partnering model from SAP's ecosystem. With the SAP PartnerEdge program for Application Development it has never been easier or more attractive for partners to develop, market and sell mobile apps to SAP's more than 250,000 customers. Our program is easy to join with low annual fees and includes a comprehensive set of enablement tools, support and more.
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In today's market, internet has become the fuel that runs the show and this is why most of you are looking to utilize it in the best manner possible. You always want to make sure that you beat off the competition from your counterparts when it comes to making use of the internet for your business promotions and operations.
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6' crankbait made of cedar weighing just under 2 ounces in a Perch pattern.
Did you use a stencil for the vertical bars?
That perch pattern looks fantastic!
Thank you Aaron, yes I used a stencil for the vertical bars
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Welcome to Librarium Online!
Join our community of 80,000+ members and take part in the number one resource for Warhammer and Warhammer 40K discussion!
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Can some one tell me pros/cons for khorne, tzeentch, iron warriors and which they would prefer and why? thanks for any help
For Khorne and Tzeentchy, I'mna talk about their troops.
Pros: Incredible CC
Blood Rage Thingy
Lord is great to mess with
Cons: Lack of anti-armor
Often regarded by others as cheesy
A bit overdone
Pros: Fearless
Can rapid fire while moving
Good to paint
Cons: Mobility or the lackthereof (except screeeeeaaamers)
Again, anti-armor issues
Not really flexible at all
Difficult to win with
Iron Warriors:
Pros: Cool
Can take Vindie and/or Bassie
6(?) Heavy Support slots
Troops good at EVERYTHING
Initially easy to paint, but can look good as your skill progresses
Cons: Often regarded as cheesy
See above
I'll post more when I think of more.
dude go Khorne! Why you ask? cause they rock in cc and they have this kick ass thing called BLOOD RAGE which will you get you closer to the enemy so you can charge and inflict pain. they may have a lack of firepower and anti-armour but they make up for that in CC and if you tool up the lord with khorne stuff and other stuff then hes kick ass. so pick KHORNE!!!!!!!!!!
"ALL YOUR BASE ARE BELONG TO US"
(raise fist in defiance)
http://www.allyourbasearebelongtous.com/fl...allyourbase.swf this is so *****ing awesome!!!!!!!
Thnx Chaosbrynn
if you wanna be win alot ( cheesey if your your opponents a bad looser) play khorne BERSERKERS RULE
if u want a kool looking army that will be a bit of a chalenge go tzeench
if you want a awsome allround army with awsome rules and general koolness go iron wariors OBLITERATORS RULE
-=Read the sigrules=-
Iron warriors allroud army? 9 obliterators and 4 HS (yes 4 not 6- you lose 2 FA and gain a HS) allround?
Khornate: beserker: as everyone else has said, charge up and rip em down - doesnt take much imagination to win with but can get frustrating if you play someone who has techniques to deal with them
Tzeench: as per first post
Iron warriors: as above you can sacrifice 2 FA slots and gain an extra HS, also the 0-1 limit on obliterators does not apply, they are essentialy seige experts - in an effort to balance them alot of people take some Close combat marines (as per the battle report in the latest WD) but to be honest they tend to get overwhelemed by a good Close combat army and the points would be better spent on another 3 obliterators
Everything you have been told is a lie!
How about Word Bearers with Khornite Deamons and Bloothirster running around freely. Altough then it would be like mine.
IMO definitely go with Khorne, he is the $hit. if u like CC at all then definitely go with Khorne. the berzerkers are so amazingly awesome, slap on some upgrades throw in a beefed up asp. champ. and badaboom.
my very small world eaters army which consists of merely 43 models and two heavy support wiped out a swarm of tyranids outnumbering them at least 3 to 1. i mean my daemon prince alone wiped out 2 hive tyrants, and my berzrkers destroyed row after row of gaunts. so i say KHORNE! :ph34r:
This is why Tzeentch is cooler -- TOO MANY PEOPLE PLAY KHORNE.
ya i agree with inuotaberu, i dont want to play what everyone else plays but i also want to have a balanced army, still not sure what to get tho, most likely iron warriors or tzeentch though i like the idea of khorne theres just too many players already
How many play word bearers. Lets see, they are undivided, but I always thought a bearers army with only slannesh deamons would be cool. I play word bearers, not khorne. BIG DIFFERNCE.


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The effect of peripheral lesions on cerebral somatosensory representations is well studied for experimentally induced amputations and deafferentations acquired later in life. However, few studies have investigated the brain's capacity for plastic changes in congenital malformations. We studied somatosensory-evoked fields to electrical stimulation of the bordering fingers in 10 subjects with upper extremity dysmelia in comparison with 10 control subjects using a 122-channel whole-head magnetometer. The number of developed fingers varied between two and four in the affected subjects. We localized finger representations in the primary somatosensory cortex and calculated Euclidian distances to estimate the size of the somatosensory hand area. Euclidian distances were significantly smaller in dysmelic subjects (5.7 mm) than in control subjects (11.6 mm) and were related to the number of the developed fingers on the contralateral hand. In contrast, individual finger representations were not found to be reduced. We suggest that the shrinkage of the somatosensory hand area might be related to the congenital nature of the malformation, to the smaller anatomical hand size in the affected subjects, and/or to use-dependent effects due to impaired hand function.
Representations in primary somatosensory cortex are known to be proportional, not to the size, but to the innervation density and use of body parts (Penfield and Boldrey 1937; Schnitzler et al. 2000). Furthermore, animal experiments and investigations in humans have shown that lesions to the peripheral (Druschky et al. 2000; Elbert et al. 1994; Flor et al. 1995; Merzenich et al. 1983a, b, 1984; Weiss et al. 2000) and CNS (Rossini et al. 1998) are able to induce profound changes in the organization of the somatosensory system both at the subcortical (e.g., Jones and Pons 1998; Rasmusson 1996) and the cortical level (e.g., Garraghty et al. 1994; Merzenich 1983a, b, 1984). While in some studies reorganization was observed as a local phenomenon within the representational fields of single body parts (Kelahan and Doetsch 1984; Merzenich et al. 1983a, b), others report evidence for large scale plasticity even across borders of body parts (e.g., Florence et al. 1998; Kamping et al. 2003). For example, studies in monkeys with denervated or amputated fingers have shown cortical area 3b to be occupied by enlarged representations of the neighboring fingers, while the overall size of hand representation remained the same (Merzenich and Jenkins 1993). Similarly, experimentally induced syndactyly does not alter the size of the cortical hand representation (Allard et al. 1991). In contrast, the hand representation was shown to be shrunken in human congenital syndactyly (Mogilner et al. 1993). It is conceivable that these differences may reflect the varying capacities of the CNS to reorganize depending on the subjects' age at time of the lesion (e.g., Hall et al. 1990).
To study the effect of congenital upper extremity damage on the somatosensory hand representation, we investigated subjects with different degrees of congenital upper extremity malformation induced by intrauterine thalidomide exposure. Thalidomide, when ingested during the third to sixth week of pregnancy, may cause severe malformations in the child during organogenesis (Goldman 1980; Lenz 1962; McBride 1961; McCredie 1975). Upper extremity dysmelia is the most salient symptom in the affected subjects. Because the malformations of arms and hands were innate and had persisted in these subjects for about 40 yr, we expected a smaller hand area for this group compared with normal controls. A shrinkage of the hand representation related to the number of developed fingers on the contralateral hand can be hypothesized. However, we expected the hand representation to be even smaller than can be expected from the anatomical malformation alone, due to the consecutive functional impairment in hand use. For mapping of the somatosensory hand area, we applied magnetoencephalography (MEG) in combination with source modeling. MEG has been shown to be able to reveal plasticity of the human somatosensory cortex noninvasively under diverse conditions such as peripheral deafferentation (Druschky et al. 2000; Flor et al. 1998; Weiss et al. 2000), movement disorders (Elbert et al. 1998), and excessive training (Elbert et al. 1995; Sterr et al. 1998).
Preliminary data were presented elsewhere in abstract form (Stoeckel et al. 2003).
We investigated 20 subjects (aged 36–42 yr; mean age, 39.9 yr): 10 (4 males) with normal upper extremities and 10 (6 males) with different degrees of upper extremity dysmelia due to thalidomide embryopathy. Typically, the affected subjects have bilateral malformations, which are predominantly symmetrical (Henkel and Willert 1969). Fingers are characteristically reduced systematically in radial-ulnar order from thumb (1st finger to be missing) to little finger (last finger to remain). In the participating subjects, the number of developed fingers varied between one and four (Table 1). Arms were foreshortened and poorly developed. This was even more pronounced in subjects with few residual fingers (Fig. 1). As can be seen in Fig. 1, the palm size was related to the number of developed fingers. Perception thresholds on the fingertips were determined for all subjects using the Semmes-Weinstein nylon monofilaments (Stoelting Co., Wood Dale, IL). None of the subjects reported phantom sensations for the malformed arms and hands. Lower extremities were normal in all subjects.
Prior to the experiment, subjects gave their written informed consent on the basis of the Declaration of Helsinki of 1975. The study was approved by the Ethics Committee of the Heinrich-Heine-University Düsseldorf.
Electrical stimulation was chosen to evoke well-defined and well-described cortical responses (Ploner et al. 1999). MEG is more sensitive to tangential than radial currents, thus electrically evoked responses in SI can be mainly attributed to area 3b (Hari and Forss 1999; Kakigi et al. 2000). The radialmost and ulnarmost fingers on each hand were stimulated via ring electrodes (CH Medizintechnik, Braunfels, Germany) using two Grass S88 constant voltage stimulators (Grass Medical, Quincy, MA), which delivered square-wave currents at a frequency of 5 Hz and of 0.3-ms duration. Wet electrodes were used for better conductance and were placed at the proximal interphalangeal joints, the cathode always being proximal. Fingers were stimulated in turn for trains of 20-s duration. Each recording session had a duration of ∼3 min resulting in ∼450 epochs per finger. Somatosensory-evoked fields (SEFs) related to the onset of the electrical stimuli were measured using a 122-channel whole-head neuromagnetometer (Neuromag, Helsinki, Finland) situated in a magnetically shielded room. Stimulus intensities were chosen just below the pain threshold and were at least twice the sensory threshold. Subjective perception of the intensities was reported by the subjects to be equal across all fingers. The average stimulus intensity across all subjects and fingers was 15.6 ± 4.5 (SD) V. There was no difference in stimulus intensities or evoked amplitudes for any of the two stimulated fingers of each hand across groups (Mann-Whitney U-tests for independent samples; P2-tailed ≥ 0.45).
Data were filtered on-line with a band-pass filter of 0.03–330 Hz and digitized at a sampling rate of 1,011 Hz. Eye blinks were controlled by vertical electrooculogram, and contaminated trials were rejected.
The signal was averaged off-line for each finger separately. Epochs were averaged from −230 to 230 ms with regard to stimulus onset and using a high-pass filter of 1 Hz. For further analysis, data were smoothed with a 145-Hz low-pass and a 50-Hz notch filter.
For co-registration of MEG data with the individual anatomy, a T1-weighted magnetic resonance tomography (MRT) image with 1 × 1 × 1 mm spatial resolution was acquired in each subject using a Vision scanner (Siemens, Erlangen, Germany). Data were aligned to the individual MRT image using the magnetic signals from four coils placed on the scalp during the measurement and three anatomical landmarks (nasion and bilateral periauricular points). The position of the coils with regard to the landmarks had been digitized (Isotrak fastrak, Polhemus Navigation Sciences, Colchester, VT) outside the shielded room before MEG data acquisition. Using a spherical volume conductor model, single equivalent current dipoles were used to explain the evoked fields. A selection of channels around the area with the largest response and the first peak with clear bipolar distribution were used for dipole fitting in SI of the contralateral hemisphere. Only sources explaining ≥80% of the field variance (goodness-of-fit) when the dipole moment was maximal were accepted for further analysis. In a second approach, single dipoles were fitted when local field power was maximal in a time window ranging from 15 to 120 ms (cf. Druschky et al. 2000; Elbert et al. 1995, 1997, 1998; Weiss et al. 2000). Because both approaches yielded similar results, only results based on the first peak will be reported in detail.
As in previous studies, we used the Euclidian distance between the stimulated fingers' representations to estimate the size of the somatosensory hand area (Druschky et al. 2000; Elbert et al. 1995, 1997, 1998; Flor et al. 1998; Maldjian et al. 1999; Sörös et al. 1999). These distances were pooled across hemispheres and compared between groups. Because dysmelia is a bilateral malformation disorder, distances were not compared between hemispheres in individual subjects. The size of the representation of individual fingers was estimated by the cortical baseline-to-peak amplitude and by dividing the size of the hand area by the number of developed fingers on the contralateral hand.
Perception thresholds on the fingertips ranged from 16 to 833 mg (median = 170 mg) and were significantly lower in the dysmelic subjects compared with the control group (P2-tailed = 0.009; Mann-Whitney U-test). There were no systematic differences in the perception threshold across fingers in either group.
Dipoles with localization in contralateral SI were found in all subjects and conditions. One dipole was excluded from further analysis because goodness-of fit was only 76%. Goodness-of-fit across all other sources was 93.25 ± 4.39% (SD). Latencies to the first peak were shorter in the malformation group (27.1 ± 12.1 ms) compared with the control group (36.1 ± 7.7 ms). This difference was significant for all stimulated fingers (P1-tailed ≤ 0.02) except for the radial finger of the dominant hand (P1-tailed = 0.06). The shorter latencies were most likely due to the foreshortened arms in the dysmelic subjects. Indeed, latencies were significantly (Spearman rank-correlation rs = 0.4; rcrit = 0.38) related to the length of the arms as estimated by the number of fingers (5 fingers = no foreshortening; 2 fingers = severe foreshortening).
Figure 2 shows the localization of dipoles related to the stimulation of D1 und D5 in one representative control subject together with the corresponding magnetic field distributions.
SI sources in the dysmelic subjects had similar localization and orientation but were closer to each other (Fig. 3). The average Euclidian distance of the dipoles was 11.6 ± 5.3 mm in subjects with normal upper extremities (pooled across hemispheres) and was significantly (P1-tailed < 0.001) reduced to 5.7 ± 1.7 mm in subjects with malformed upper extremities (Mann-Whitney U-test).
Across both hemispheres, distances were significantly correlated with the number of fingers on the contralateral hand (rs = 0.58, corrected for ties according to Siegel and Castellan 1988; rcrit = 0.38; Fig. 4).
The mean size of individual finger representations, the "space per finger" was 2.3 mm in the control group and 1.9 mm in the dysmelic subjects. There was no difference concerning the space per finger across groups (P2-tailed = 0.33). Average baseline-to-peak amplitudes were 10.8 ± 4.37 nA in the control group and 11.31 ± 6.27 nA in the dysmelic subjects. Amplitudes were not significantly different across groups for any of the four stimulated fingers (P2-tailed ≥ 0.45).
Average localization of finger representations followed the known somatotopy in the control group (Fig. 5). In the dysmelic subjects, the average localizations of the radial- and ulnarmost fingers were so close together that these appeared virtually identical in the inferior-superior direction. The lack of a clear somatotopic arrangement in this group was probably due to the proximity of finger representations in relation to the localization accuracy of the MEG method.
Our data show a significantly reduced hand representation in subjects with congenitally malformed upper extremities in combination with improved perceptual detection capacities on the fingertips. The reduction in size is clearly different from experimentally induced conditions in adult monkeys (Allard et al. 1991; Merzenich and Jenkins 1993), where the overall size of the hand area remained the same after finger webbing or amputation. However, our data correspond to a study of Mogilner et al. (1993), who showed a shrunken hand representation in congenitally webbed fingers. Therefore the timing of damage might be critical for the striking difference. The smaller skin area of the affected hands and arms in thalidomide embryopathy may have determined the relatively smaller somatosensory hand area from early development onward. Furthermore, the malformation of the hand had persisted in our subjects for about 40 yr. As far as we know there are no studies neither in animals nor humans where an acquired lesion dates back a similar amount of time. We cannot decide from our data whether the overall outline of the hand area possesses less potential for changes in later life or whether the changes we observed here needed the considerably long period of 40 yr to emerge.
However, there are alternative explanations for the differences between our findings and previous studies. First, the dysmelia syndrome is different from the lesions produced in previous experimental studies. In the latter, middle fingers were either amputated (Merzenich and Jenkins 1993) or webbed (Allard et al. 1991). In contrast, bordering fingers beginning with D1, D2, etc. are characteristically missing in dysmelia. Because there are no experimental studies in which bordering fingers have been amputated, we don't know whether this would produce a shrunken hand area in later life as seen in this study for a congenital disorder. When middle fingers are amputated, the preserved bordering finger representations might have prevented the invasion of neighboring body part representations and the shrinkage of the hand area. Likewise, the size of the hand representation might appear normal in congenital conditions when middle fingers are missing. Further support for this hypothesis comes again from the study of Mogilner et al. (1993), where bordering fingers were involved in the complex congenital malformation that was associated with a shrunken hand representation.
Interestingly, in the study of Mogilner et al. (1993), the hand area was shown to expand substantially within 1 mo after surgical separation of the webbed fingers. This substantial change occurred in adulthood and can be seen as use-dependent plasticity brought about by the newly gained functional independence of the fingers. Use-dependent plasticity is also another strong candidate to explain a reduced hand representation in our dysmelic subjects. Just as excessive and dedicated training results in larger somatosensory representations (Braun et al. 2000; Elbert et al. 1995; Stoeckel et al. 2004), the disuse of body parts was followed by a shrunken motor representation within weeks (Liepert et al. 1995). Likewise, a reduced motor representation after stroke was shown to return to normal size after a functionally effective, rehabilitative training (Liepert et al. 2000). The dysmelic subjects participating in this study reported to accomplish almost all everyday actions with their hands. Compensatory use of the feet was restricted to very few actions in all but one subject (S10; compare Stoeckel et al. 2004). However, due to the changed anatomy, thalidomide-damaged subjects with malformed upper extremities use their hands differently (Sievert 1965). Opposition movements (pinch grip) are only possible between neighboring fingers because the thumb is always missing. In normal subjects, the thumb has many degrees of freedom for movements and is able to accomplish opposition movements with all other fingers of a hand. Therefore the thumb is the most important finger for sensorimotor hand function such as object manipulation (Kunesch et al. 1989; Seitz et al. 1991). Consequently, the less elaborate hand use might primarily explain or contribute to the reduced hand area in the dysmelic subjects. However, a shrinkage was only shown for the entire hand area, while baseline-to peak amplitudes and the estimated space per finger indicate normal sized individual finger representations in the dysmelic subjects. Higher perceptual detection capacities in the dysmelic subjects compared with the control group would suggest even larger than normal individual finger representations in these subjects. Larger finger representations together with a shrinkage of the overall hand area imply overlapping representational cortical fields, which is known to result in reduced localization capacities (Mogilner et al. 1993; Sterr et al. 1998). However, localization capacities across different fingers were described to be normal in the dysmelic subjects (Stoeckel et al. 2004). We assume that the lower detection thresholds were most likely due to a lower degree of horny skin on the finger tips rather than to larger cortical finger representations.
The enlargement of the somatosensory hand representation as described by Elbert et al. (1995) and Mogilner et al. (1993) was most likely based on an enlargement and/or a separation of individual finger representations. Whether the shrinkage of the hand area was caused by the early onset of the malformation disorder, anatomical peculiarities, or life-long use-dependent effects cannot be decided on the basis of these data. Furthermore, an interaction of all of these factors cannot be excluded.
Another unresolved question is whether a smaller hand area is paralleled by enlarged representations of the other body parts. For example, in patients with facial nerve palsy, the arm representation expanded into the face area (Rijntjes et al. 1997). While the neighboring face area is a possible candidate for enlargement, an invasion by the neighboring arm representation seems unlikely. The length of the arms is typically also reduced in the dysmelia syndrome and covaries with the number of fingers (Henkel and Willert 1969). Therefore the arm representation itself is also expected to be reduced. An overall shift in favor of an enlarged foot representation is rendered unlikely by findings of Stoeckel et al. (2004), because in a group of dysmelic subjects with two to four developed fingers, the foot representation was not shown to be enlarged or shifted. It seems even possible that a silent area remains in congenital malformation syndromes because reorganization was shown to be more extensive in acquired than congenital amputation (Flor et al. 1998; Jain et al. 2000, 2001). Alternatively, the entire SI area could be smaller in the dysmelic subjects. This question is difficult to address with MEG due to methodological limitations. We suggest that this issue would best be addressed in a morphometric study.
M. C. Stoeckel was supported by the Deutsche Forschungsgemeinschaft (SFB 194) and the Research Foundation of the Medical Faculty of the Heinrich-Heine-University Düsseldorf. A. Schnitzler was supported by the Volkswagenstiftung (I/73240).
R. J. Seitz and A. Schnitzler are members of the Biomedizinisches Forschungszentrum of the Heinrich-Heine-University Düsseldorf. We thank F. Schmitz and Dr. Joachim Gross for helpful support during the course of the study.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2005 by the American Physiological Society


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The Disappearing Lollipop
Written by Meryl-Lynn Pluck
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8 pages
Meryl-Lynn Pluck
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I love Lovereading because I often never know what to read and this helps you find a good book. I have recommended this to many people.Shannon-Louise Masters – age 15
It is THE website to use for narrowing down your search for any book. Definitely knocks the socks off any other book review website.Nickey and Tomasz Hawryszczuk


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