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Mechanism of Inhibition of Neointimal Formation by the Angiotensin-Converting Enzyme Inhibitor Cilazapril
A Study in Balloon Catheter–Injured Rat Carotid Arteries
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Abstract We investigated the mechanism of inhibition of neointima formation by the angiotensin-converting enzyme inhibitor cilazapril in a rat model of balloon-catheter injury in the carotid artery. We looked for the effects of cilazapril on all phases of the response to injury, ie, on proliferation of smooth muscle cells (SMCs) in the media, their migration, their proliferation in the neointima, and their deposition of extracellular matrix in the neointima. Although treatment was discontinued after 2 weeks, the inhibitory effect of cilazapril on neointimal formation was evident even 52 weeks after injury. The amount of extracellular matrix deposited in the intima during cilazapril treatment was decreased by 20% 2 weeks after injury, but no effect was seen if tissues were analyzed at 4 or 52 weeks. [3H]Thymidine-labeled cells (pulse labeling as well as 14-day continuous labeling) showed a decrease in SMC labeling in the tunica media by 50%, but no inhibition in the labeling indices was seen in the neointima. The fraction of unlabeled neointimal cells in the cilazapril-treated rats as judged from continuous labeling experiments was inhibited by 86%. Taken together, these data suggest an antiproliferative effect on medial SMCs and an inhibition of SMC migration into the intima by cilazapril. Since intimal extracellular matrix deposition was only delayed, the decrease in medial SMC proliferation and subsequent migration seems to be the main reason for the reduction of neointima formation.
- Received February 22, 1995.
- Accepted August 2, 1995.
Cilazapril is the first ACE inhibitor shown to inhibit intimal thickening after balloon-catheter injury in rats.1 The phenomenon has been reproduced with other ACE inhibitors2 3 4 and other animal models of intimal hyperplastic diseases (eg, vein graft hyperplasia in rats5 and rabbits6 and allograft hyperplasia in rats7 ). The underlying mechanisms, however, are still unclear. In balloon catheter–injured guinea pigs cilazapril is effective,8 but in other animal species such as swine9 10 or nonhuman primates11 little or no efficacy has been demonstrated. A retrospective study on the efficacy of ACE inhibitors on restenosis in humans suggests a beneficial effect12 ; in contrast, a prospective randomized trial with cilazapril was negative.13 These species differences prompted us to further analyze the mechanisms underlying the inhibition of intimal thickening after balloon-catheter injury by cilazapril.
The sequence of events leading to intimal thickening after balloon-catheter injury in the rat is well documented. SMCs proliferate in the media14 15 ; after 2 to 7 days the SMCs migrate into the intima, after which they start a transient phase of proliferation that lasts about 2 weeks.15 Finally, for about 4 weeks they continue to deposit large amounts of ECM material.16 Little data are available on the effect of ACE inhibitors on the proliferation of SMCs in vivo. Prescott et al4 reported no inhibition of proliferation in the tunica media after balloon-catheter injury in the rat by the ACE inhibitor benazeprilate. Capron et al2 showed a small but insignificant decrease with ramipril. Both studies suggest that inhibition of ACE caused inhibition of migration of SMCs into the intima. We focused on the effect of cilazapril on all four phases of SMC activation after balloon-catheter injury to the rat. We show that cilazapril inhibits incorporation of thymidine into medial but not intimal SMCs. ECM deposition was inhibited only slightly and transiently, and we conclude that a main mechanism of inhibition of neointimal formation by cilazapril is inhibition of SMC migration from the media into the intima.
Carotid Artery Injury
Male Wistar Kyoto rats (300 to 400 g) were obtained from BRL. The animals were anesthetized with sodium pentobarbital 40 mg/kg IP (Vetanarcol, Veterinaria). The left carotid artery was exposed at the bifurcation, and a 2F embolectomy catheter was inserted.1 16 The inflated balloon was pulled through the common carotid artery three times. After permanent ligation of the external carotid artery the wound was closed, and the animals were kept in pairs and fed commercial chow and water ad libitum.
Drug Administration
Cilazapril was administered as a food admixture starting 6 days before surgery.1 During the first and second day after ballooning cilazapril was administered by gavage (10 mg/kg) to ensure uptake. On the basis of a food consumption of 20 g per rat per day, 200 mg cilazapril was mixed with 1 kg rat chow to give a daily supply of ≈10 mg cilazapril per kg body wt. Food consumption by the experimental animals was controlled every other day.
DNA Synthesis In Vivo
Cellular proliferation in vivo was assessed by using [3H]thymidine labeling. Two protocols were used. To estimate the proliferation rate per day, exactly 1.85×107 Bq/kg tritiated thymidine (2.5×1011 Bq · mmol−1 · L−1, 3.7×107 Bq/mL; New England Nuclear) was injected intraperitoneally at 17 hours, 9 hours, and 1 hour before death.15 To determine the cumulative proliferation rate over the first 2 weeks after injury, an osmotic minipump with a volume of 2 mL (2ML2 Alzet) filled with 7.4×107 Bq [3H]thymidine (2.5×1011 Bq · mmol−1 · L−1, 3.7×107 Bq/mL) was implanted in the peritoneum at the time of arterial injury.
Labeled nuclei were detected by autoradiography on perfusion-fixed cross-sections (see below) that were dipped in Kodak NTB2 emulsion and developed after 2 weeks at 4°C. The thymidine index was expressed as (labeled nuclei/total nuclei)×100.
Prior to perfusion fixation (2.5% glutaraldehyde in 0.1 mol/L cacodylate buffer, pH 7.4, for 15 minutes at 90 mm Hg), the rat was deeply anesthetized with pentobarbital 150 mg/kg IP. The abdomen was opened, and the rat was killed by further intravenous injection of pentobarbital. The chest was quickly opened, and a gavage cannula (No. 20) was inserted into the aorta via the left ventricle. Blood was flushed out with phosphate-buffered saline before fixation was started. The vessels were carefully removed and fixed further by immersion in the same solution for 90 minutes at 4°C, cut into six equal segments (≈6 mm long), and subjected to epoxy resin embedding (Epon 812). Semithin sections were cut from the central segments (≈12 and 18 mm distal from the aortic origin of the carotid artery) and stained with toluidine blue and basic fuchsin.17 Cross-sectional areas of vessel wall tissues were determined by using a computer-aided morphometry system (Diasys II; Heinz Meyer, DataLab).
Electron Microscopy
For transmission electron microscopy (Philips CM12/STEM), the perfusion-fixed and embedded material described above was used. After immersion fixation, the center segments of the arteries were rinsed overnight in 0.1 mol/L cacodylate buffer and 7% sucrose, pH 7.4, at 4°C. Sodium permanganate (0.05%) in cacodylate buffer, pH 7.4, was used for postfixation at 4°C for 60 minutes. After dehydration with ethanol and propylene oxide and embedding in epoxy resin, ultrathin sections were cut and stained with uranyl acetate and lead citrate.
Determination of the Amount of ECM
The relative area occupied by ECM versus cellular bodies was determined on cross sections at 14, 28, and 365 days after balloon-catheter injury by using the point-hit method.18 A total of 12 transmission electron micrographs (×6000) were taken from each cross section such that the micrographs covered the entire thickness of the intima.16 One hundred thirty test points over each micrograph were analyzed by using a video camera and a semiautomatic computer-driven morphometry system (diasys II). The number of test points covered by ECM was expressed as the percent of total test points.
Statistical Analysis
Treatment effects on cross-sectional areas were analyzed by using the Kruskal-Wallis test (proc npar1way, SAS). In the case of overall significance (P<.05), treatment effects on separate days were compared by using the Wilcoxon test. Treatment effects on proliferative activity and absolute number of nuclei were analyzed by two-way ANOVA by using the factors "treatment" and "time" and their interaction (proc glm, SAS). In the case of overall significance (P<.05), treatment effects on separate days were compared by using the least-squares mean from an ANOVA with treatment nested in time.
Neointima Formation
From our morphometry data (Fig 1⇓), it was evident that cells appeared in the intima 5 days after balloon-catheter injury, and substantial thickening was seen after 9 days. Neointimal thickening during the first 2 weeks after injury was inhibited in the cilazapril-treated rats by 81%1 as judged from neointimal cross-sectional areas (Fig 1⇓). If the number of nuclear profiles per cross section was used as a crude measure of intimal cellularity, in cilazapril-treated rats a reduction of 76% was evident (Table 1⇓). On the basis of these data, we wanted to know whether cilazapril delays or actually inhibits neointimal thickening. When rats were treated continuously with cilazapril for 52 weeks (Fig 2⇓), neointima formation was inhibited by 75%. When the drug was discontinued 2 or 4 weeks after balloon injury and the rats were analyzed after 52 weeks, the neointima was still reduced (40% if cilazapril was administered for 2 weeks and 57% for 4 weeks; Fig 2⇓). These results suggest that cilazapril inhibits neointimal size mainly through events atanearlystageaftervessel-wall injury.
Thymidine Labeling
In placebo-treated rats the peak of medial thymidine labeling was observed 4 days after injury (Fig 3⇓, top). Cilazapril-treated rats showed labeling indices in medial SMCs, which were significantly reduced (P=.0001 by two-way ANOVA). A maximum inhibition (45%) was reached at day 4 after injury. In the intima, however, no significant difference in maximum labeling indices could be seen between the two experimental groups (Fig 3⇓, bottom). In some rats tritiated thymidine was infused continuously during the entire observation period (0 to 14 days after balloon-catheter injury). The results from the pulse-labeling experiment could be substantiated, as overall labeling in the media was reduced by 50% in cilazapril-treated rats, whereas no difference between the two groups of rats was evident in the intima (Table 2⇓).
The proliferative response of medial SMCs is thought to reflect the replacement of those SMCs that are destroyed by balloon-catheter injury. The density of nuclear profiles in the tunica media in both groups increased significantly (P<.0001 by ANOVA) between 2 and 14 days after injury by a factor of 2.4 in the placebo-treated rats (from 839±192 nuclei per millimeter-squared at day 2 to 2040±118 nuclei per millimeter-squared at day 14) and by a factor of 1.6 in cilazapril-treated rats (from 1169±155 nuclei per millimeter-squared at day 2 to 1895±141 nuclei per millimeter-squared at day 14). Whereas the increase in nuclear density was significantly smaller in cilazapril-treated rats (P<.05), the final nuclear density at day 14 did not differ significantly between the two groups.
Calculation of the Fraction of Unlabeled Neointimal Cells
From our data we have no indication of an inhibition of neointimal cell proliferation after cilazapril treatment. This raises the question of whether ACE inhibition could inhibit SMC migration. From our continuous thymidine-labeling experiments we could determine which cells in the neointima never took up the label. These unlabeled cells were most probably derived from the tunica media via migration through the internal elastic lamina without entering S phase throughout the experiment. Thus, they could be used as a marker for cellular migration. The results of this experiment are summarized in Table 3⇓. The neointimal cell number in cilazapril-treated rats 2 weeks after injury was reduced by 75%. In these tissues the reduction of unlabeled neointimal cell numbers was in the same order of magnitude (85%). The most likely explanation for this profound reduction in the number of unlabeled cells is the inhibition of SMC migration from the tunica media into the intima during cilazapril treatment.
ECM Volume
More than half the neointimal volume in the balloon catheter–injured rat carotid artery is occupied by ECM.16 We wanted to know, therefore, whether cilazapril would reduce the volume fraction of ECM in the neointima. We examined the cross-sectional area occupied by extracellular material in the tunica intima for up to 52 weeks after injury in placebo- and cilazapril-treated rats (Fig 4⇓). Despite a significant reduction of total neointimal size after cilazapril treatment (Fig 2⇑), no long-term (up to 52 weeks) change in the intimal extracellular volume fraction was evident. Two weeks after injury, however, the matrix was reduced by 20% in the cilazapril-treated group. From these data it was clear that a delay of ECM deposition could contribute to the reduced neointimal size 2 weeks after injury but that no long-term changes could be expected.
Our data clearly show that cilazapril inhibited medial SMC proliferation in balloon catheter–injured rat carotid arteries. In contrast, intimal SMC proliferation was not inhibited by the drug. The amount of ECM in the intima was normal, but the time course of deposition was delayed. Our data further suggest that the inhibition of migration of SMCs from the intima to the media was a main cause for the inhibitory effect of cilazapril on overall intimal thickening.
We analyzed the total intimal cross-sectional area as well as the relative amount of intimal ECM for up to 52 weeks after injury. While we found a persistent reduction of neointimal cross-sectional area during cilazapril treatment in the range of 80%, we detected no effect of cilazapril on ECM deposition except at the 2-week point, when a 20% reduction was evident.
From these data we reasoned that cilazapril exerts its inhibitory activity by affecting intimal SMC number or size rather than ECM. This interpretation could be substantiated since the actual number of nuclei per cross section was reduced in parallel with the reduction in total neointimal cross-sectional area. When overall neointimal size was analyzed for up to 52 weeks after injury, cilazapril maintained its inhibitory effect despite discontinuation of drug treatment after 2 or 4 weeks. Discontinuation of drug treatment after 2 rather than 4 weeks caused a significantly smaller inhibition of neointimal thickening 52 weeks after injury, implying that processes are affected that extend for more than 2 weeks. Nevertheless, this suggests that ACE inhibition permanently reduces the cellular content of the neointima via a mechanism that is active during an early stage of neointimal development. These data can be interpreted to indicate that cilazapril affected those cells that initially populate the neointima by inhibiting either medial SMC proliferation or migration. Alternatively, the proliferative activity of the intimal cells could have been lowered by cilazapril. Using two different labeling protocols (pulse labeling for 24 hours and continuous labeling from the time of injury until death at day 14), we found no evidence for a decrease in labeling indices in intimal cells in cilazapril-treated rats, strongly suggesting that proliferation of these cells is not inhibited by the drug. No data are available yet to relate this finding to other ACE inhibitors. Despite this lack of efficacy of cilazapril, Ang II is shown to increase intimal proliferation in a similar model19 if given in pharmacological doses. Several studies suggest that ACE inhibition effects are mediated via the Ang II receptor 1 (AT1) pathway.4 20 21 AT1 receptors are predominantly present in the neointima,22 but AT2 receptors have also been detected.23 Our results could be interpreted such that either the reduction of Ang II in the neointima after ACE inhibition was insufficient, as discussed by Dzau24 and Dzau and Pratt,25 or that endogenous Ang II does not drive neointimal proliferation.
The reduction in neointimal formation is seen only at high doses of cilazapril (>3 mg · kg−1 · d−1; data not shown). It has been shown for other ACE inhibitors at similar doses that besides inhibition of Ang II, increased kinins and nitric oxide contribute to the inhibition of neointimal formation.26 27 It was not the subject of this study to elucidate the pharmacology of ACE inhibition. We can clearly show, however, that even at high doses ACE inhibition fails to inhibit intimal SMC proliferation.
As far as medial SMCs are concerned, inhibition of Ang II receptors in vivo reduces proliferation,4 and administration of Ang II in pharmacological doses increases medial proliferation,19 suggesting a direct role of Ang II in the process. When we looked for proliferative activity in the tunica media, a significant reduction by drug treatment was revealed by two-way ANOVA. Such an inhibitory effect was not described for other ACE inhibitors but may have been missed in studies using benazeprilate4 or ramipril2 due to the smaller sample sizes. Evidence suggests that bFGF is the main mitogen for medial SMC proliferation; bFGF is released from injured SMCs and acts in a paracrine fashion on neighboring intact SMCs.28 There is no evidence that bFGF is also an endogenous mitogen for intimal SMC proliferation, since an antibody that inhibits SMCs in the media failed to inhibit proliferation in the intima.29 Since cilazapril has a selective efficacy for the reduction of medial SMC proliferation, the bFGF pathway may be linked to ACE, as recently suggested by Fishel et al,30 who report an induction of ACE in cultured SMCs by bFGF.
One way to explain the apparent paradox that cilazapril inhibits intimal thickening without affecting intimal proliferation is to postulate that cilazapril inhibits SMC migration from the media into the intima. From our continuous thymidine-labeling experiments we were able to estimate the number of nonproliferative cells in the neointima. From our calculation we can conclude that the appearance of cells in the neointima that never took up thymidine is inhibited by cilazapril by 85%. Labeled cells from the same tissues were inhibited to a similar extent (75%). This clearly shows that cilazapril not only affects medial cells in a proliferative but also in a nonproliferative stage.
Since migration of both proliferative as well as nonproliferative cells was affected, we have no indication that a subpopulation of SMCs is a target of ACE inhibitors. However, as the diversity of SMCs in terms of ontogenic origin,31 proliferative behavior,32 33 and ACE activity34 is well known, we cannot exclude that a subpopulation of cells is prone to ACE inhibition.
In contrast to SMC proliferation, we know little about SMC migration, nor do we have a direct marker for this process. Indirect evidence has therefore been used to describe SMC migration in vivo.4 The observation of nonproliferating cells in the neointima prompted Clowes and Schwartz35 to propose the concept that SMC migration must occur to initiate neointimal thickening. They calculated that the number of migrating cells that do not proliferate is the same as the number of cells that show proliferative activity.
It is also possible that the extent of migration of medial SMCs is a direct consequence of proliferation in the media; hence, the reduction of neointimal thickening could also be directly related to reduced medial proliferation. Since cytokines can induce processes linked to migration as well as proliferation, it is difficult to separate the two. The question arises of whether the inhibition of medial SMC proliferation in cilazapril-treated rats may contribute to the reduced neointimal thickening. We may postulate that a certain level of cellular density must be reached in the injured media before migration can occur. A reduced proliferation in the media in cilazapril-treated rats may therefore directly explain the reduced migration.
The failure of ACE inhibition in several animal species such as pigs and monkeys9 10 11 to affect neointima formation can be explained by species differences, eg, the presence or absence of ACE-bypassing enzymes such as chymase.36 37 The very high dose of ACE inhibitor used in rats certainly limits the possibility to extrapolate the data to other species. The finding that cilazapril fails to inhibit intimal SMC proliferation even at high concentrations could suggest, however, that in those arteries in which SMCs exist in the intima before drug treatment there is no efficacy in reducing neointima formation after balloon-catheter intervention. Intimal SMCs are found in most large arteries and in particular in diseased human coronary arteries subjected to angioplasty.
In summary, we provide evidence that the ACE inhibitor cilazapril inhibits medial SMC proliferation in injured rat carotid arteries. The number of nonproliferating cells in the neointima was also reduced, suggesting an inhibitory effect on SMC migration. Whereas medial SMC proliferation was inhibited, no effects on intimal SMC proliferation or long-term ECM deposition were observed. This could predict a low efficacy of ACE inhibitors in injury models with preexisting intimal SMCs in which migration may play a subordinate role.
Selected Abbreviations and Acronyms
|angiotensin-converting enzyme
|Ang II
|angiotensin II
|basic fibroblast growth factor
|extracellular matrix
|smooth muscle cell
We thank Christine Michael, Käthi Schietinger, Feridun Schodjai, Georges Wdonwicki, and Philippe Wyss for excellent technical assistance and Dr L. Banken for his advice and help in handling statistics.
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- Mechanism of Inhibition of Neointimal Formation by the Angiotensin-Converting Enzyme Inhibitor CilazaprilJürgen Fingerle, Rita M.K. Müller, Herbert Kuhn, Michael Pech and Hans Rudolf BaumgartnerArteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1945-1950, originally published November 1, 1995http://dx.doi.org/10.1161/01.ATV.15.11.1945
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- Mechanism of Inhibition of Neointimal Formation by the Angiotensin-Converting Enzyme Inhibitor CilazaprilJürgen Fingerle, Rita M.K. Müller, Herbert Kuhn, Michael Pech and Hans Rudolf BaumgartnerArteriosclerosis, Thrombosis, and Vascular Biology. 1995;15:1945-1950, originally published November 1, 1995http://dx.doi.org/10.1161/01.ATV.15.11.1945
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NEFTA Classic - what a cracker!!
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USDA Awards $35M for Renewables and Energy Efficiency
Agriculture Secretary Ed Schafer announced that 639 individuals and businesses have been selected to receive $35 million in grants and loan guarantees for renewable energy systems or to improve energy efficiency in farm and business operations.
The grants and loan guarantees are being awarded through USDA Rural Development's Section 9006 Renewable Energy Systems and Energy Efficiency Improvements program. Of the $35 million, $27.5 million are grants and $7.4 million are guaranteed loans.
The funding will support a variety of energy-production and energy-saving efforts such as replacing a grain dryer with an energy-efficient model for Chad Brandt of Oakes, N.D., who will receive about $67,000 in grant and loan. The new model is expected to cut energy costs by more than 20 percent.
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text: Starfish Pendant And Earring Set by SUMMER AND SILVER £58$96.59€66.26$79 3 customer reviews(3) In stock Favourite Favourite View your favourites chain lengthchain length16 inch (40 cm)18 inch (45 cm)chain length16 inch (40 cm)18 inch (45 cm)chain length16 inch (40 cm)18 inch (45 cm)chain length16 inch (40 cm)18 inch (45 cm) pendant ; earrings separately ?pendant ; earrings separately ?Pendant (- £22)Earrings (- £34)pendant ; earrings separately ?Pendant (- $36.63)Earrings (- $56.62)pendant ; earrings separately ?Pendant (- €25.13)Earrings (- €38.84)pendant ; earrings separately ?Pendant (- $29.96)Earrings (- $46.31) quantity by SUMMER AND SILVER Location: Birmingham, GB read seller's profile see seller's complete range more items from this seller Juju Wave Pendant by SUMMER AND SILVER £36$59.95€41.13$49.03 Sunflower Pendant by SUMMER AND SILVER £26$43.30€29.70$35.41 Sunflower Earrings by SUMMER AND SILVER £26$43.30€29.70$35.41 Sterling Silver Wrap Bangle by SUMMER AND SILVER £56$93.26€63.98$76.28 Silver Calla Lily Brooch by SUMMER AND SILVER £52$86.60€59.41$70.83 Silver Lunar Stud Earrings by SUMMER AND SILVER £22$36.63€25.13$29.96 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS ask seller a question save for later A glittering silver starfish set comprising pendant and matching earrings. The finish on this starfish gives it a glittering shine which catches the light beautifully. A simple yet eyecatching design suitable for everyday wear or that special occasion. The pendant comes on a 40cm (16 inch) silver snake chain, the earrings are of a stud design. All our pieces make gorgeous gifts for any occasion All items have complimentary gift wrap. Summer and Silver are based in the world famous Birmingham Jewellery Quarter 45cm (18 inch) chain available on request made from: All our products are sterling silver dimensions: The pendant is approximately 3.4cm in width and the earrings measure 2.5cm in width product code: 173452 3 customer reviews read about our product rating system ratings guide trusted independent customer feedbackforum excellent bad good poor This product is dispatched to you by SUMMER AND SILVER. You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. SUMMER AND SILVER's return policy Please see notonthehighstreet.com's returns policy.


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Judy Garland The Amsterdam Concert December 1960 (Live) (2-CD)
|List Price:
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|$2.50 (10% Off)
Temporarily Out of Stock: We'll get more as soon as possible
Format: CD (2 Discs)
sku: 35GSQ
Brand New
CD Details
- Released: November 13, 2012
- Originally Released: 2012
- Label: First Hand
Tracks on Disc 1:
- 1.Judy Garland interviewed by Nikko van Fleet
- 2.Male dialogue
- 3.Orchestral Number
- 4.Ageeth Scherphuis announcement
- 5.Orchestral Introduction
- 6.Norrie Paramor interviewed by Ageeth Scherpius
- 7.Garland Overture
- 8.When You're Smiling
- 9.Medley: Almost Like Being in Love / This Can't Be Love
- 10.Talk - 'It's lovely to be here in Amsterdam...'
- 11.Do it Again
- 12.Talk - Paris hairdresser story
- 13.You Go to My Head
- 14.Talk - 'I wonder what all the people listening to the radio are thinking...'
- 15.Alone Together
- 16.Talk - 'I'm known, if I'm known at all...'
- 17.Who Cares?
- 18.Talk - 'The next starts with a moan...'
- 19.Puttin' On the Ritz
- 20.Talk - 'I think the next is a sort of strip-tease tempo...'
- 21.How Long Has This Been Going On?
- 22.Just You, Just Me
- 23.The Man That Got Away
- 24.San Francisco
- 25.Talk - 'I could stay here for a week...'
- 26.Sid Luft interviewed by Ageeth Scherphuis
Tracks on Disc 2:
- 1.That's Entertainment
- 2.I Can't Give You Anything but Love
- 3.Talk - 'Now you know you can't get any attractive pictures from there...'
- 4.Come Rain or Come Shine
- 5.Talk - 'I ran out of breath on the last note...'
- 6.You're Nearer
- 7.Talk - 'There's another nice song...'
- 8.If Love Were All
- 9.Talk - 'Shall we go on with this nonsense...'
- 10.A Foggy Day (in London Town)
- 11.Talk - 'We had about twenty stagehands in Paris...'
- 12.Zing! Went the Strings of My Heart
- 13.Talk - 'I can hear a marvellous woman off there...'
- 14.Stormy Weather
- 15.Medley: You Made Me Love You / For Me and My Gal / The Trolley Song
- 16.Rock-a-Bye Your Baby (with a Dixie Melody)
- 17.Bows
- 18.Talk - 'Thank you very, very much...'
- 19.Over the Rainbow
- 20.Talk - 'You know we don't have too many orchestrations...'
- 21.Swanee
- 22.Announcers
- 23.Talk - 'I think it's rather beastly to keep coming on and going off...'
- 24.It's a Great Day for the Irish (false start)
- 25.It's a Great Day for the Irish
- 26.Announcers
- 27.Talk - 'I don't know what we can do...'
- 28.After You've Gone
- 29.Talk - 'I think we're going to have to just do one of them over again...'
- 30.San Francisco
- 31.Talk - 'God bless you and goodnight...'
Song previews provided courtesy of iTunes
Product Description:
Personnel: Judy Garland (vocals); David Lee (piano).
Audio Remasterer: Deborah Spanton.
Liner Note Author: Jonathan Summers.
Recording information: Tuschinski Theatre, Amsterdam, The Netherlands (12/10/1960).
Photographers: Dirk Van Der Made; Harry Pot.
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Description of the accommodation:
Rooms, services Take a few-days trip to Minneapolis and enjoy the hospitality of JW Marriott Minneapolis Mall of America Minneapolis. The hotel is offering 22 tastefully furnished rooms to those seeking accommodation in Minneapolis. If you feel like having a meal not included in your chosen type of catering, you can always taste local dishes in the restaurant of the hotel. Relaxing wellness services will be available to you at the hotel, an indoor pool will also be waiting for you. To learn more about the exact range of services of JW Marriott Minneapolis Mall of America Minneapolis (including services for an extra fee) and the exact equipment of the rooms, please check the information sheet below.
Payment In order to finalize the reservation you may be required to provide credit card guarantee or advance payment by credit card, depending on the chosen room, date and price.
Arrival, opening hours The earliest time of check-in is 15:00, the latest time of check-out is 12:00. You will be able to speak with the personnel in English.
JW Marriott Minneapolis Mall of America Minneapolis foglalás, szoba árak Foglalás, szoba árak
- For accurate prices please enter the date of your trip!
Accommodation services
- Indoor pool
Own restaurant
Hairdryer, Fridge, Desk in the room, Washing machine, Tea/coffee-maker


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Welcome to the DNN Community Forums, your preferred source of online community support for all things related to DNN.In order to participate you must be a registered DNNizen
My host has a limited DB size to 300MB. So I am trying to find ways to reduce it's size. 2 of the biggest culprits are the tables SearchItemWordPosition and SearchItemWord combined almost 100meg in size. What are those tables for and can/how do I reset/wipe them?
Thanks for any help or input.
DNN provides a suite of solutions for creating rich, rewarding online experiences for customers, partners and employees. DNN products and technology are the foundation for 750,000+ websites worldwide. In addition to our commercial CMS and social community solutions, DNN is the steward of the DotNetNuke Open Source Project.


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Jeanne DuPrau's The City of Ember meets Louis Sachar's Holes in this imaginative and hilarious middle grade novel from New York Times bestselling author Michael Perry.
When the world started to fall apart, the government gave everyone two choices: move into the Bubble Cities…or take their chances outside. Maggie's family chose to live in the world that was left behind. Deciding it's time to grow up and grow tough, Maggie rechristens herself "Ford Falcon"—a name inspired by the beat-up car she finds at a nearby junkyard. Ford's family goes to this junkyard to scavenge for things they can use or barter with the other people who live OutBubble. Her family has been able to survive this brave new world by working together. But when Ford comes home one day to discover her home ransacked and her family missing, she must find the strength to rescue her loved ones with the help of some unlikely friends.
The Scavengers is a wholly original tween novel that combines an action-packed adventure, a heartfelt family story, and a triumphant journey of self-discovery in a world where one person's junk is another person's key to survival. Katherine Applegate, author of the Newbery Medal winner The One and Only Ivan, raves "Michael Perry pulls out all the stops in this colorful tale."
Servizi per i clienti:
• Password dimenticata
• Controllo e modifica dei propri dati
• Verifica degli ordini effettuati
Opportunità per aziende e enti:
• Servizi per le biblioteche
• Programma di affiliazione (Informazioni generali)
• Accesso a TradeDoubler
• Accesso a Zanox
Concessionaria di pubblicità:
• A. Manzoni & C.
Con la collaborazione di per il settore editoria libraria
Ufficio stampa: Daniela Ravanetti
Altri siti del network IBS:
• Libraccio.it
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• Librerie Ubik
Internet Bookshop Italia S.r.l.
Sede Legale Via Giuseppe Verdi n.8 - 20090 Assago MI
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R.E.A. Milano 1542508
Capitale sociale € 1.054.852 i.v.
IBS è una società soggetta a direzione e coordinamento di Emmelibri srl


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MATH 290 First Week
MATH 290 First Week MATH 290
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Class Notes
Anna Thomas
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This 7 page Class Notes was uploaded by Anne Henselman on Friday January 23, 2015. The Class Notes belongs to MATH 290 at Kansas taught by Professor Myunghyun Oh in Spring2015. Since its upload, it has received 192 views. For similar materials see Elementary Linear Algebra in Math at Kansas.
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Date Created: 01/23/15
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TPG vs iiNet: Battle of the ISPs
These two ISPs have grown into fully-fledged telcos creating great wealth for shareholders, but can they hold their own in a more competitive landscape?
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Cast your mind back to 2005. George 'Dubya' Bush has just been inaugurated for his second term. The Airbus A380 'superjumbo' has made its first test flight and Youtube has shared its first video, co-founder Jawed Karim's Me at the zoo.
Communications are becoming digital and convergence is the catch-cry. Voice over IP (VoIP) services such as Skype are becoming mainstream and we're on the cusp of being...
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Victor Davis Hanson: The Bipartisan Agreement on America's Role in the World is Coming to a CloseRoundup: Historians' Take
NRO contributor Victor Davis Hanson is a senior fellow at the Hoover Institution. His The Savior Generals will appear in the spring from Bloomsbury Books.
War seems to come out of nowhere, like rust that suddenly pops up on iron after a storm.
Throughout history, we have seen that war can sometimes be avoided or postponed, or its effects mitigated — usually through a balance of power, alliances, and deterrence rather than supranational collective agencies. But it never seems to go away entirely.
Just as otherwise lawful suburbanites might slug it out over silly driveway boundaries, or trivial road rage can escalate into shooting violence, so nations and factions can whip themselves up to go to war — consider 1861, 1914, or 1939. Often, the pretexts for starting a war are not real shortages of land, food, or fuel, but rather perceptions — like fear, honor, and perceived self-interest.
To the ancient Greek philosophers Heraclitus and Plato, war was the father of us all, while peace was a brief parenthesis in the human experience. In the past, Americans of both parties seemed to accept that tragic fact.
After the Second World War, the United States, at great expense in blood and treasure, and often at existential danger, took on the role of protecting the free world from global Communism. After the collapse of the Soviet Union, both Democratic and Republican administrations ensured the free commerce, travel, and communications essential for the globalization boom.
Such peacekeeping assumed that there would always pop up a Manuel Noriega, Slobodan Milosevic, Saddam Hussein, or Osama bin Laden who would threaten the regional or international order. In response, the United States — often clumsily, with mixed results, and to international criticism — would either contain or eliminate the threat. Names changed, but evil remained — and as a result of U.S. vigilance the world largely prospered.
This bipartisan activist policy is coming to a close with the new "lead from behind" policy of the Obama administration...
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- Does the 'Father' of the 1948 Ethnic Cleansing Narrative Really Want to Recant His Words?
- Max Boot wants to know "what the hell happened to my Republican Party?"


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If you log in, you can comment on buildings, submit new photos or update photos that you've already submitted.
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Description: Forest Cottage
Grade: II
Date Listed: 10 April 1954
English Heritage Building ID: 156581
OS Grid Reference: SP0092161413
OS Grid Coordinates: 400921, 261413
Latitude/Longitude: 52.2509, -1.9879
Location: High Street, Feckenham, Worcestershire B96 6HS
Locality: Feckenham
Local Authority: Redditch Borough Council
County: Worcestershire
Country: England
Postcode: B96 6HS
Incorrect location/postcode? Submit a correction!
Explore more of the area around Feckenham, Worcestershire at Explore Britain.
REDDITCH B HIGH STREET (east side)
9/105 No 16, Forest Cottage
[formerly listed as
10.4.54 No 16 (Catholic House)]
House. Early Cl7; restored mid-C20. Timber-framed with rendered infill on
sandstone ruble and brick-plinth; painted brick refacing, replacement walling
and additions; machine-tiled roof. Four framed bays aligned north-east/south-
west with framed single-bay intersecting wing at south-west end. Single
storey and attic with dormers. Framing: mainly three panels from sill to
wall-plate, short straight braces in upper corners; collar and tie-beam
trusses; truss at south-west end of main part has three struts to collar
and V-strut in apex; truss at west end and also wing truss to north-west
has two struts to collar. North-west street elevation: windows are C20
leaded casements; ground floor of main part has a 3-light and a 2-light
window with plank weatherings, another 2-light window and also a large
square-headed archway in the north-east end bay; four gabled dormers with -
2-light windows; main entrance to right has a lean-to porch in angle with
wing and a C20 door. Interior not inspected. C20 alterations and additions
at rear.
Listing NGR: SP0092561416
This text is a legacy record and has not been updated since the building was originally listed. Details of the building may have changed in the intervening time. You should not rely on this listing as an accurate description of the building.
Source: English Heritage
Listed building text is © Crown Copyright. Reproduced under licence.


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Again, whether you fully believe Donaghy or not, he does provide a fascinating perspective into the world of refereeing that simply no one else can provide.


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Hall of Fame basketball legend Rick Barry says LeBron James is the greatest small forward to ever play the game. And he thinks James can get even better. Barry told Scott Ferrall of CBS Radio that of all the great small forwards-- including Scottie Pippen, Elgin Baylor and Larry Bird -- that James is the best. "There's never been anybody like him with his size, his athleticism, his feel for the game," said Barry. Wait, better than Bird -- with his three rings and sport-changing game?
Yup, especially if you look at Barry's three considerations. Bird had the feel, and the height if not the size, but Bird would be the first to tell you James is head and shoulders above him athletically. There's still the matter of pure shooting, where Bird has an edge, but add defense and LeBron James comes out on top.
[Check out the "Most Interesting Finds" on Amazon ]


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$DE, an agriculture and construction equipment maker, posted lower 1Q16 results, hurt by decline in global farm economy, weakness in construction equipment markets and lower revenues. $DE said net income fell 34.4% to $253.8MM, or $0.80 per share compared to $386.9MM or $1.12 per share a year ago. Revenue fell 13.4% to $5.52Bil.
Jeff Bezos, my inspiration next to Steve Jobs is going to review the Everything Store $AMZN's financial results today after hours. As an investor/user, I like Amazon Prime and it's success over several parts of the world. What's your take on Amazon?
Of all the Wall St firms out there, Goldman Sachs $GS is the most revered for the way they're run - hiring the best, highly competitive, a closely-knit peer group and making tons of profits for the shareholders. An interesting interview of its CEO Llyod Blankfein by Carlyle groups chief David Rubenstein
Great results from $TSLA, however the question remains if Tesla can continue to scale up to produce the cars in the quantity it promises. Model 3 numbers need to be in multiples of what they are producing right now. Wish them the best, will keep an eye as I am still not convinced that they can scale easily.
Watching $TSLA Oct 28th $215 Calls for possible entry


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Goodbye, Riverwest
I moved to Riverwest in 1993 and rented an apartment with a friend on Pierce Street. I came in search of cheap beer and cheap rent and because so many of my friends had relocated already to the neighborhood in search of the same things.
When I wasn't writing confessional poetry on the forearm of a philosophy major, I drank Stein at the Stork Club and the Hop Inn. I danced at the Mars Hotel, watched crappy punk bands at Quarters (hey, I was in a crappy punk band so I can say this) and ate mayo-heavy sandwiches at this brand new cafe that brought the '90s coffee shop concept to Milwaukee called Fuel Cafe.
When I was super broke, I went on the Lakefront Brewery tour for $2 when the brewery was still a one-room operation on Chambers Street, next to Dino's, where I ate about a thousand plates of fried fish.
In 1997, I bought two houses in Riverwest: a single family and a duplex for about a nickel each. In 2003, I sold these houses for about a dime each to pay lawyers so I could bring a 9-month-old Guatemalan boy with wild curly hair and a penchant for mushed-up bananas over the Texas border.
Both of my kids spent most of their lives hanging out in Riverwest, from friends' backyards to the Riverwest Co-op, Gordon Park, Children's Outing Association (COA), the playroom at Rio West Cantina and in stimulating, colorful classrooms at La Escuela Fratney.
In 2005, I created an outdoor communal living space on Booth Street with a friend who owned three properties surrounding my property. We literally tore down fences, put up one fence around the parameter of the four yards and created a green space that, over time, looked like this place my kids believe in called heaven.
Riverwest inspired me. I wrote hundreds, maybe thousands, of poems and essays and articles from my bubblegum pink home office. I planted begonias and broccoli and gourds and garlic and tomatoes and tulips and sometimes, sunflowers on the sly in public places just to spruce up the neighborhood. (Actually, many of the Riverwesterners I know are like sunflowers with hardy stems that soak up toxins and with faces filled with cheer and light.)
So many people and places defined my 18 years of Riverwest bliss, from the lady with the snake wrapped around her neck at Locust Street Festival to the always-2-for-1 happy hour at Art Bar to Wednesday night bowling at the Polish Falcon.
Over the years, people moved from Riverwest in fits and spurts to "safer" neighborhoods. And I witnessed crimes, even took a couple of direct hits, but I never felt the need to move away despite suggestions that I should.
"Riverwest is not for everyone," was usually all I would say. "But it works for me."
And then, one day, it didn't. Not because of the neighborhood, but because of my need to plant sunflowers in fresh spaces. After a series of endings, I had this deep desire to bust out of the one-square-mile radius I had lived in my entire life. And so I folded up my futon, extinguished my incense and moved to Walker's Point.
space_cadet | March 8, 2012 at 4:15 p.m. (report)
Very nice article that reminds me of so many great times and interesting people I knew in Riverwest from about 1993 until about 2006. I grew up in the 60s and 70s, knew Molly when she was 18, glad to see her recording worthwhile experiences to share. I think I understand the comment re. snobbery, based on nickles and dimes, though I never saw her as such. Perhaps there is something unsettling about referring to a house price as a "nickle", which is apparently code for a large amount of money ($50,000?). I'd love to be wealthy enough to see 50 grand as a nickle, 100 grand as a dime!! Thank goodness some of us made it, and the rest will keep trying. Love.
|Rate this:
ntylla | June 24, 2011 at 10:15 a.m. (report)
I too have just left Riverwest after 6 years. I'm now back in Bayview after living there first in the early 90's( when it wasn't cool to live there.) I didn't move for any reason but Molly's, a new perspective on life. New view. I miss Riverwest for it's originality and tenacity, my numerous excellent friends and acquaintences. It was the first neighborhood I truly cared about, proud I was an important part of the texture of living there. I volunteered at the power down festival, helped out at Rockerbox, enjoyed the Locust St. Festival, spent my money in all of the neighborhood restaurants and bars. Indeed there are issues, but as with anywhere, you take the bad with the good and try to do your part to make it just a bit better. (ie planting flowers, starting a block watch, attending meetings at the police department, etc) And, if you look at is as a whole, it's Milwaukee. And anywhere in Milwaukee is cool enough.
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bennyjet | June 22, 2011 at 10:22 a.m. (report)
you had me up until the ending. Was there a larger reason or specific incident that led to the move? Why Walker's Point? Feels like a lateral move to me. Will there be a follow-up: "Hello, Fifth Ward".
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bennyjet | June 22, 2011 at 10:20 a.m. (report)
You had me right up until the end. It seems like you have more to say, like an incident which leads to the move, or better explanation to the specific choice in the move (which feels kind of lateral, quite frankly). Is there going to be a part 2: "Hello, Walkers Point"?
|Rate this:
Bayviewboozer | June 22, 2011 at 5:47 a.m. (report)
Why all the bayview haters? Not enough violence for you.
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Join the ROV/AUV interest group for a day in Monterey. We are visiting the Monterey Bay Aquarium Research Institute, MBARI, from 12 noon until 5pm Saturday July 20th. Check it out out,
Now THIS was an AMAZING meetup. I brought the kids and my biz partners kid. We all made underwater ROVs, raced hand-made phytoplankton. The best was we all got to meet the rock-star (in our minds, they were very humble & articulate) scientists, especially the ones from Ventana, one of the mbari underwater ROB. THANK YOU THANK YOU THANK YOU Andra for making us aware of this event.
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Kurhotel Austria: Find photos, reviews, information, amenities and compare prices for 3 stars hotels in Bad Worishofen, Germany.
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I admit the name for this post is intimidating. Because I may not be the best person to give out suggestions for this type of topic. I never had a relationship with my father(s). I never knew my biological father, and the relationship that I have with my step-dad is pretty much non existent.
But I have ideas what I would do, if things were different. I seen people giving out relationship advises, and sometimes those people are not even in a relationship themselves.
When I was planning to write this post, I spent time looking for right ideas, right products for Fathers Day.. So I can list them all here for you guys. But when I was checking out those things, I just dont see anything that was just right for a father. Sure, some of the gifts were really cool like the genuine leather wallet, espresso machine, Armani fragrance, Burberry tie, golf gloves, candles that smell like bacon, six pack of Heineken.. the list is endless. But do you think, thats what your father really want?
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Eighteen-year-old Nallan Ino has grown up in a world torn apart by a devastating nuclear war. Since her induction into the Nin-Jitsu Training school, her life has been far from ordinary. In the middle of honing her new found abilities, Nallan, along with her fellow ninjas in training, are launched into the harsh reality of the world outside the safety of their school. They must travel to the place that is the seat of the Order, the countryas new government. Nallan and her companions have no suspicion of the secrets that will come to light there. During her journey, she encounters a dangerous foe bent on her destruction and lost souls looking to her for salvation. Somehow she must find a balance between the needs of desperate people and her own limitations. Nallan must learn to trust her instincts and listen to her ancestors before she loses everything. Atlantis Child tells the epic story of Nallanas journey to find the truth about her past and her future.He brushes my hair behind my ear, making my heart do backflips. aYoua#39;re not that bad.a aReally?a I am so a dork. He leans into me, then the next thing I know Ia#39;m on the ground, Kashia#39;s weight crushing down on meaand not in a romanticanbsp;...
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Winston County Homecoming is scheduled May 23, in conjunction with the Red Hills Festival. There will be a minimuseum with historical photos, class photos, and composites, interesting artifacts, and much more.… Read more
Category: News
Noxubee National Wildlife Refuge Youth Fishing Rodeo set
by Comments Off on Noxubee National Wildlife Refuge Youth Fishing Rodeo set• •
JACKSON – Children 4 to 15 years old are invited to a youth fishing rodeo at the Fishing Derby Ponds beginning at 7:30 a.m. on Saturday, April 25. The free event is hosted by the Mississippi Department of Wildlife, Fisheries, … Read more
ECCC hosts Student Art Exhibit
by Comments Off on ECCC hosts Student Art Exhibit• •
The East Central Community College Art Department will host its annual Student Art Exhibition Monday, April 20 through Friday, May 1 in the Vickers Fine Arts Center on the Decatur campus.
The exhibit will feature drawings, paintings, prints, sculpture and … Read more
Cornerstone Clinic annual meeting set for May 3
by Comments Off on Cornerstone Clinic annual meeting set for May 3• •
The meeting for Cornerstone Clinic will be held Sunday, May 3 at 3 p.m. in the fellowship hall in First United Methodist Church. Cornerstone Clinic provides Health care and medicine for our uninsured residents in Winston County.… Read more
ICC's Choir, Chamber Singers set April 27 concert including local
by Comments Off on ICC's Choir, Chamber Singers set April 27 concert including local• •
Itawamba Community College's Choir and Chamber Singers will perform in concert at 6:30 p.m., Apr. 27, in the W.O. Benjamin Fine Arts Center auditorium at the Fulton Campus.
Among the selections are "Joshua Fit the Battle of Jericho," "Lamentations of … Read more
Sports Schedules – 04/22/15
by Comments Off on Sports Schedules – 04/22/15• •
Junior College Baseball
3 p.m. — Holmes at Itawamba (DH)
3 p.m. — Southwest Miss. at East Central (DH)
4 p.m. — Northwest Mississippi at EMCC (DH)
College Baseball
6:30 p.m. — Memphis at Ole Miss… Read more
Noxapater baseball, softball teams begin playoffs this week
by Comments Off on Noxapater baseball, softball teams begin playoffs this week• •
By Austin Bishop
Winston County Journal.
The Noxapater High School baseball team and the Noxapater High School softball team will both begin play in their respective state playoffs on Thursday.
The Lady Tigers will host either Resurrection or Sacred Heart … Read more
Let's Be Neighbors – 04/22/15
by Comments Off on Let's Be Neighbors – 04/22/15• •
Carolyn Mills, provides a weekly view from the community.
The special election for a US Congressman to replace Nunnley is coming up May 12th and several men are running. Kline Shepherd called together several friends to meet one of those … Read more
ECCC students selected for Percussive Arts Society All-Star Ensemble
by Comments Off on ECCC students selected for Percussive Arts Society All-Star Ensemble• •
East Central Community College students Caleb Franklin of Morton and Anna Girling of Carthage were recently selected to participate in the Mississippi Percussive Arts Society All-Star Ensemble, announced Ed Girling, assistant director of bands and percussion instructor.
The All-Star Ensemble, … Read more
Kids-N-Kats Fishing Rodeo set for May 2
by Comments Off on Kids-N-Kats Fishing Rodeo set for May 2• •
From press and staff reports
The Friends of the Legion State Park will be sponsoring the Kids-N-Kats Fishing Rodeo on Saturday, May 2, 2015.
The fishing rodeo is open to youth ages 15 years of age and younger, with registration … Read more


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Been a Long Time
Few things send rock fans scrambling for the skip button (and the Maalox) faster than the sound of a symphony orchestra on top of electric guitars. Right? Absolutely. There have been some grievous offenses committed in the name of classical crossovers "Bohemian Rhapsody," Bat Out of Hell, Metallica's S&M album but overall, enough time has passed since Guns 'N' Roses' "Live and Let Die" remake that the idea isn't completely repulsive. Since 2005, the Boston Pops' "Pops on the Edge" series has enlisted the likes of Ben Folds, Decemberists and Nickel Creek to help sell tickets to the young folks, and God knows Arcade Fire's Neon Bible has its Mahleresque moments.
The Houston Symphony, meanwhile, is in for some "Good Times Bad Times" of its own Friday. For about 12 years, Berklee College of Music grad Brent Havens has been arranging and conducting Led Zeppelin's catalog with various U.S. orchestras. Just in case, he brings a band, featuring Robert Plant soundalike Randy Jackson, along for backup. "I didn't think die-hard Zep fans necessarily wanted to see a symphony orchestra playing," Havens told the Press last week. "I thought it would be more attractive if we literally had somebody out there wailing on the vocal parts."
Houston Press: What were some of the challenges in arranging Zeppelin's songs?
Houston Symphony and Led Zeppelin
Brent Havens: The cool thing about Zep is they have some interesting harmonic structures. I think they were a bit ahead of their time in that, with Jimmy Page doing some multi-triadic stuff with a triad chord over the top of another one. Then rhythmically, doing some unusual material, where he'll play a 7/8 bar and the very next bar will be a 3/8 bar, and then a 4/4 bar.
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HP: Are those things comparable to any orchestral music?
BH: Yeah. One of my favorite composers, Prokofiev, uses a great deal of meter changes, and in terms of harmonic structure, he's out there a little bit. Same with Stravinsky, to the point where they had riots because it was so dissonant and unusual.
HP: Besides "Kashmir" and maybe "Immigrant Song," which songs mesh best with an orchestra?
BH: "I'm Gonna Crawl," which is a blues tune and actually started out with a Mellotron, or whatever that synthesizer thing John Paul Jones was using. I transcribed that exactly as he played it and it works beautifully. "All My Love," because that starts out with just strings. Going into the chorus, the orchestra just soars way over the top of the band, which I thought translated really, really well.
HP: Any you had to steer clear of?
BH: There are a number of tunes that areÉepics [laughs]. They're ten or 11 minutes long. Some of those epics we don't really get a chance to do because we want to try to get as much in as we can during the time we have. Also, some songs are a little too repetitive. They'll be six or seven minutes of pretty much the exact same thing. That gets really difficult to figure out what to do with the orchestra over and over.
The Houston Symphony plays "The Music of Led Zeppelin: A Rock Symphony" at 7:30 p.m. Friday, July 20, at Jones Hall, 615 Louisiana, 713-224-7575.
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News : Wichita to Lose 200 Jobs with Call Center Closure
Wichita, KS, USA, Apr 30, 2015 -- Ally Financial is streamlining its customer support services, and it will mean a loss for Wichita.
The Wichita Eagle reports the company, which provides financial products to auto dealers, plans to close its Wichita call center by the end of the year. The work being performed in Wichita will be moved to Ally Financial sites in Minnesota and Florida.
About 200 jobs will be lost.
Posted by Veronica Silva Cusi, news correspondent
Source: http://www.bizjournals.com
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About Ally Financial:
Ally Financial Inc., previously known as GMAC Inc., is a bank holding company headquartered in Detroit, Michigan, United States at Tower 200 of the Renaissance Center.
Published: Friday, May 1, 2015
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Just Good Foods is on the bottom floor of the Rose Street Market on Rose Street south of Kalamazoo Avenue. The basement level is just that. It's a wide open space that has been filled with tables on one side and a full service deli and catering operation that takes up the back area. The deli features salads, sides and sandwiches. Free wireless.
303 N Rose St
Kalamazoo, MI 49007
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When President Nixon signed the Endangered Species Act in 1973, it is doubtful anyone contemplated the "Humanis doctoris." But despite recent efforts to open new medical schools and increase the size of existing medical school classes, a severe physician shortage looms on the horizon.
In November 2008 the Association of American Medical Colleges looked into the supply of doctors and predicted a shortage of 125,000 physicians by 2025. While these shortages may be most pronounced in primary care, they cover the gamut of medical and surgical subspecialties. There simply are not enough doctors in the pipeline. Unfortunately, the so-called health-care-reform legislation that recently passed via reconciliation along party lines will only exacerbate this trend, with the corollary being increased wait times for appointments and the inevitable rationing of care.
Obamacare will bring the dearth of physicians to disastrous new levels. No doubt they may become the next endangered species, at least in their current form: the brightest, best educated, best trained, and most dedicated. Despite living in an environment that has become ever more hostile since Medicare's implementation in 1965, this resourceful species has somehow managed to teeter on. Physicians deserve credit for demonstrating unparalleled resilience in the face of an increasingly litigious and bureaucratic habitat dominated by predatory regulators and third-party administrators. All things considered, it is amazing physicians have survived this long. It is important to remember that despite their ability to heal and save lives, as mere mortals they can only tolerate so much. Remember, even the symbol of American preeminence, the bald eagle, has been in extremis.
Obamacare may very well be the proverbial last straw. To describe the new law as bad for physicians would be an understatement. It transfers more control of important health care decisions typically made between doctor and patient to faceless unaccountables in Washington, D.C. It creates roughly 159 new committees, agencies, and bureaucracies with virtually limitless power to dictate physician decisions. As a result, doctors will encounter increasing bureaucracy, paperwork, diminishing autonomy, and declining job satisfaction. They will be compelled to waste more time complying with regulations and, as a consequence, have less time to devote to patients and the practice of good medicine. Time constraints will force physicians to see more patents in less time to maintain their own standard of living. Sick people and the quality of care will suffer the most.
— Jason D. Fodeman, M.D. is an internal-medicine resident at the University of Connecticut and a former graduate health-policy fellow at the Heritage Foundation.


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