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CEO Carol Bartz's forced departure from Yahoo was no big surprise -- the company had been visibly floundering all year. But even those who expected Bartz's firing were shocked by how the ax finally swung: Yahoo board chairman Roy Bostock dumped her unceremoniously by phone.
Bartz relayed the news -- and the manner of her firing -- to her former charges in an all-hands email soon after. "To all, I am very sad to tell you that I've just been fired," the short missive began. But the best bit was its ending line: "Sent from my iPad."
It's like Bartz hung up with Bostock and snatched up the nearest keyboard to bang out her final farewell.
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Oh, Carol. The tech world will never be quite so colorful -- and full of four-letter words -- without you. -- Julianne Pepitone
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Friday, June 07, 2013 8:30 PM
Gotham Comedy Club, New York, NY
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Featuring Vic Henley, Jon Fisch & Ophira Eisenberg!
Featuring Vic Henley, Jon Fisch & Ophira Eisenberg!
Colin Kane:
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If you like dirty comedy, Colin Kane's your man.
If you like dirty comedy, Colin Kane's your man.
An insult comic that acknowledges the line and leaps over it, Kane is best known for his in-your-face delivery and off-the-cuff crowd work. Featuring an unlikely blend of piercing bite and authentic heart, Kane's R-rated act tackles sex, relationships, race... and everyone who is brave enough to sit in the front row.
Kane recently made his film debut in a breakout role opposite Kevin Hart in "The Wedding Ringer," which was the #1 comedy in America for three weeks in a row. He has a special on Showtime, won Howard Stern's "Kill or Be Killed" comedy competition, and performs for our troops whenever possible through the
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Kane's popularity has proven contagious across the country, and has happened mostly via word-of-mouth from a dedicated fan base. Anyone who comes to one of his shows is guaranteed to come back with 20 of their friends.
Kane's popularity has proven contagious across the country, and has happened mostly via word-of-mouth from a dedicated fan base. Anyone who comes to one of his shows is guaranteed to come back with 20 of their friends.
A Los Angeles resident, the born-and-bred New Yorker sells out theaters and comedy clubs across the country. Now it's time for you to see why.
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Cambridge IGCSE Drama Teacher Guide
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Cambridge IGCSE Drama Teacher Guide by Emma Brown, Gail DealPrepare for the Cambridge Drama IGCSE 2016 syllabus with an approach that helps to create a varied, stimulating and enjoyable learning environment that enables students of different confidence and ability levels to flourish. * Be ready to teach the new syllabus (for first examination in June 2016) with this brand new series which has been fully matched to the Cambridge IGCSE(R) Drama syllabus. * Have full confidence in the content and approach of the series which is written by a team of highly experienced authors, who have over 20 years of teaching experience. * Enable students to learn a range of skills, such as how to build their self-awareness and how to reflect on their performance. This will build their knowledge and self-confidence, which extends beyond the course itself and helps equip them for life. * Know that the series has an international feel in terms of both language used within the text, and plays, scenarios and contexts selected. * Make use of the excellent supporting components of the series which include a range of exciting and engaging scripts from real plays, role plays for warm ups, examples of stimuli for Devised pieces, and still images from productions which show key elements from performances. * Help students monitor their learning using the 'Learning Log' and 'Check your progress' features, where students review, record and evaluate their work.
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The aim of this study is to elucidate the effects of interleukin-6 (IL-6) on the expression and activity of the epithelial sodium channel (ENaC), which is one of the key mechanisms underlying tubular sodium reabsorption. M-1 cortical collecting duct cells were treated with IL-6 (100 ng/ml) for 12 h. Real-time polymerase chain reaction and immunoblotting were employed to examine the mRNA and protein abundance. Transepithelial voltage (Vte) and resistance (Rte) were measured with an ohm/voltmeter (EVOM, WPI). The equivalent current was calculated as the ratio of Vte to Rte. Treatment with IL-6 (n = 5) increased the mRNA abundance of α-ENaC by 11 ± 7% (P = not significant), β-ENaC by 78 ± 14% (P = 0.01), γ-ENaC by 185 ± 38% (P = 0.02), and prostasin by 29 ± 5% (P = 0.01), all normalized by β-actin. Treatment with IL-6 increased the protein expression of α-ENaC by 19 ± 3% (P = 0.001), β-ENaC by 89 ± 21% (P = 0.01), γ-ENaC by 36 ± 12% (P = 0.02), and prostasin by 33 ± 6% (P = 0.02). The amiloride-sensitive sodium current increased by 37 ± 5%, from 6.0 ± 0.4 to 8.2 ± 0.3 μA/cm2 (P < 0.01), in the cells treated with IL-6 compared with controls (P = 0.01). Aprotinin (28 μg/ml), a prostasin inhibitor, reduced the amiloride-sensitive sodium current by 61 ± 5%, from 6.1 ± 0.3 to 3.7 ± 0.2 μA/cm2 (P = 0.01). The magnitude of the IL-6-induced amiloride-sensitive sodium current in the presence of aprotinin dropped by 57 ± 2%, from 8.6 ± 0.2 to 4.9 ± 0.2 μA/cm2 (P < 0.01). This study has identified a novel function of IL-6, namely, IL-6 may activate ENaC. Therefore, renal inflammation mediated by IL-6 likely contributes to impaired pressure natriuresis.
- distal tubule
- prostasin
- pressure natriuresis
interleukin-6 (IL-6), a pleiotropic cytokine produced by numerous cell types, plays an important role in the inflammation cascade. IL-6 exerts multiple effects on infiltrated inflammatory cells and on structural cells in a variety of tissues and organs, including kidneys (8, 24, 44, 48). Data suggest that IL-6-involved inflammatory processes in the kidney contribute to the pathogenesis of nephropathy (28, 40). IL-6-deficient mice were resistant to HgCl2-induced acute kidney injury compared with wild-type mice (42). Renal function decline in patients with type 1 diabetes was correlated with elevated excretion of IL-6 in urine (67). Renal cortical mRNA expression of IL-6 was 3.4-fold higher in diabetic than in nondiabetic rats, which was significantly associated with urinary albumin excretion (41). In patients with diabetic nephropathy, IL-6 mRNA was expressed by glomerular resident cells and interstitial cells in the renal tissue (56). IL-6 was also shown to be linked to hypertensive glomerular injury (31, 47). Biopsy studies using indirect immunofluorescence microscopy showed that, in patients with kidney disease, IL-6 expression was increased in the area of glomerular and tubular inflammation and tubular atrophy (18, 19).
Furthermore, using mice with knockout of IL-6, Lee et al. (33) found that angiotensin II (ANG II)-induced hypertension was significantly dependent on IL-6. The kidneys of the IL-6 knockout mice were more capable of eliminating a salt load during ANG II infusion than were the kidneys of the wild-type mice. The hypertension caused by a high dose of ANG II and a high-salt diet was attenuated in IL-6 knockout mice (34). These data suggest that there is a powerful effect of IL-6 in mediating the rightward shift in the renal pressure-natriuresis relationship caused by ANG II and high salt intake, providing evidence for an important long-term blood pressure effect of IL-6. In addition, prenatal exposure to IL-6 resulted in hypertension, alterations in the renal and circulatory renin-angiotensin system, and decreased mean urinary sodium excretion in rats (49). However, the mechanisms whereby IL-6 regulates sodium handling remain unknown.
The epithelial sodium channel (ENaC) consists of at least three subunits (α-ENaC, β-ENaC, and γ-ENaC) and is thought to regulate the final adjustment of renal sodium reabsorption in the distal tubules (51). Therefore, sodium homeostasis, extracellular volume, and, ultimately, blood pressure are maintained by precise regulation of ENaC activity. ENaC activity is controlled by aldosterone, other hormones such as vasopressin, and a network of intracellular factors and multiple accessory regulatory proteins that are not completely understood. Prostasin, a glycosylphosphatidylinositol-anchored serine protease expressed in the distal nephron, has been shown to regulate the proteolytic processing and activation of ENaC subunits in Xenopus oocytes and a mouse cortical collecting duct (CCD) cell line (M-1 cells) (1, 13, 14, 25, 26, 30, 46, 59–61, 63, 64). Prostasin is thought to induce cleavage of an inhibitory peptide from γ-ENaC to activate the channel fully in the cell (9, 10, 25). Because of the impact of ENaC on sodium homeostasis and blood pressure control, the present study was conducted to evaluate the effects of IL-6 on the gene and protein expression of ENaC subunits and the activity of ENaC in CCD cells. In addition, we hypothesize that IL-6 might affect prostasin. We chose M-1 cells, a mammalian cell line derived from microdissected CCD of a mouse transgenic for the early region of SV40, which retains a number of the characteristics of the parental CCDs, including the expression of ENaC, high transepithelial electrical resistance (Rte), and amiloride-sensitive sodium currents (6, 55). Thus, M-1 cells have been valuable tools for studying ENaC and related regulatory proteins (29, 35, 38, 39, 58, 65).
Cell culture.
The M-1 cells were obtained and cultured as previously described (38). Briefly, the cultures were initially maintained in a defined medium consisting of equal amounts of Ham's F-12 and low-glucose Dulbecco's modified Eagle's medium (Sigma), supplemented with 2 mmol/l l-glutamine, 50 U/ml penicillin, 50 mg/ml streptomycin, 5% fetal bovine serum, growth-promoting factors (6.25 mg/ml transferrin, insulin, and sodium selenite), and 100 nmol/l dexamethasone. After the cells reached confluence, they were passaged to permeable membranes (Transwells, Costar). Cells were synchronized by serum deprivation for 24 h and treated with IL-6 (100 ng/ml) for 12 h. Finally, cells were harvested for mRNA and protein extraction. The Alamar blue viability assay showed that the cell survival rate was ∼85%, after treatment with 100 ng/ml IL-6 for 12 h.
Real-time PCR.
Predesigned TaqMan gene expression assays for mouse α-ENaC (Mm00803386_m1), β-ENaC (Mm00441215_m1), γ-ENaC (Mm00441228_m1), prostasin (Mm00504792_m1), and β-actin (Mm00607939_s1) were purchased from Applied Biosystems (Foster City, CA). Total RNA was extracted from M-1 cells, and 5 μg of total RNA were reverse-transcribed to cDNA with oligo(dT) primers using Superscript III. Real-time PCR was performed with the ABI 7500 fast real-time PCR system (Applied Biosystems). Thermal cycling conditions consisted of 95°C for 20 s, followed by 40 cycles of 95°C for 3 s and 60°C for 30 s. Every sample was done in triplicates. Three negative controls without cDNA template were also included in each plate. The fold changes were determined by the cycle threshold (2−ΔΔCt) method using Sequence Detection version 1.3 software (Applied Biosystems).
Western blot analysis.
Total lysate of the M-1 cells was used to measure the protein levels of the three ENaC subunits. Treated cells were washed three times with PBS, centrifuged, and lysed by PARIS kit (catalog no. AM1921, Ambion).
Membrane fractions of the M-1 cells were used to measure the protein levels of prostasin. As previously described by Chen et al. (13), treated cells were lysed on ice for 1 h with Tris-buffered saline (TBS) containing 1% Triton X-114 (Sigma) and protease inhibitors. After centrifugation at 12,000 rpm for 30 min, the supernatant was placed on a sucrose cushion [6% (wt/vol) sucrose in TBS containing 0.06% Triton X-114]. The solution was then incubated at 37°C for 3 min and centrifuged at 300 g for 3 min at room temperature to separate the detergent phase (pellet) and the aqueous phase. The aqueous phase was removed, and the detergent phase (pellet) was precipitated with acetone and resuspended in ice-cold TBS.
Prepared protein samples were separated with 10% SDS-PAGE and transferred onto polyvinylidene difluoride membranes. The membrane was blocked with 5% nonfat milk in PBS + Tween 20 for 1 h and then immunoblotted with commercially available antibodies against α-ENaC (1:500 dilution, rabbit anti-mouse, polyclonal; Affinity BioReagents, Golden, CO), β-ENaC (1:250 dilution, rabbit anti-human, polyclonal; Santa Cruz Biotechnology, Santa Cruz, CA), γ-ENaC (1:500 dilution, rabbit anti-rat, polyclonal; Millipore, Billerica, MA), and prostasin (1:500 dilution, mouse anti-human, monoclonal; Becton, Dickinson, Franklin Lakes, NJ). To check for equal loading, membranes were reprobed with an antibody against β-actin (1:800 dilution; Santa Cruz Biotechnology). Bands were visualized using chemiluminescence substrate followed by exposure to X-ray film. The band densities were measured by densitometry using the Quantity One program (Bio-Rad Laboratories, Hercules, CA). Data are expressed as the ratio of IL-6-treated to control cells after normalization to β-actin expression.
Electrophysiological transepithelial measurements.
Early passage 11–17 M-1 cells were used for electrophysiological transepithelial measurements. As previously described (35), transepithelial voltage (Vte) and Rte were measured with an ohm/voltmeter (EVOM, WPI, Sarasota, FL). Vte was measured by means of a set of 2 Ag-AgCl electrodes and determined with the apical solution as reference. Rte was measured by passage of current through the cell monolayer and measurement of the resulting voltage gradient across the cells. The equivalent current (Ieq) was calculated as the ratio of Vte to Rte and was normalized by dividing Ieq by the surface area (113 mm2) of active membrane. After evaluations of the dose dependency and time course (see results), a final concentration of IL-6 (100 ng/ml) was used for 12 h to study the effects of IL-6 on ENaC function. To determine the magnitude of ENaC-mediated sodium transport across the apical membrane, an ENaC inhibitor (amiloride, 10 μmol/l) was added to the cell medium for 10 min. Similarly, cells were incubated with aprotinin (28 μg/ml) for 12 h to inhibit the activity of prostasin. Cells were also treated with aldosterone (1 μmol/l) for 12 h from the apical side of the cells as a reference to evaluate the effects of IL-6 on the electrophysiological transepithelial parameters.
Statistical analyses.
Values are means ± SE. Statistical analyses were performed with SPSS 15.0 (SPSS, Chicago, IL). For Western blotting and gene expressions, Student's t-test was used to determine statistical significance between two groups before and after experimental manipulations. For electrophysiological transepithelial measurements, ANOVA was used to determine the statistical significance among groups before and after experimental manipulations. Results were considered significant if P < 0.05.
Effects of IL-6 on the gene expression of ENaC subunits and prostasin.
Treatment with IL-6 (100 ng/ml) for 12 h increased the mRNA abundance of α-ENaC by 11 ± 7% (P = not significant), β-ENaC by 78 ± 14% (P = 0.01), γ-ENaC by 185 ± 38% (P = 0.02), and prostasin by 29 ± 5% (P = 0.01; Fig. 1).
Effects of IL-6 on the protein expression of ENaC subunits and prostasin.
Treatment with IL-6 (100 ng/ml) for 12 h increased the protein expression of α-ENaC by 19 ± 3% (P = 0.001), β-ENaC by 89 ± 21% (P = 0.01), γ-ENaC by 36 ± 12% (P = 0.02), and prostasin by 33 ± 6% (P = 0.02; Fig. 2). In contrast with the previous report, we were not able to detect the presence of prostasin in the cell medium (39), which could be due to the low level of prostasin secreted into the cell medium from the cell membrane.
Amiloride-sensitive Ieq in response to IL-6.
IL-6 concentrations of 10, 100, 150, and 200 ng/ml were used to test the potential dose dependency of Ieq (n = 3 for each dose). The amiloride-sensitive Ieq was increased only ∼5% by 10 ng/ml IL-6 (P > 0.05) and ∼37% by 100 ng/ml IL-6 (P < 0.01). The higher doses, 150 and 200 ng/ml, however, appeared to decrease the amiloride-sensitive Ieq ∼30% (P = 0.04) and ∼40% (P = 0.01), respectively. Thus, 100 ng/ml was used to test the effects of IL-6 on amiloride-sensitive Ieq in the M1-cells. Next, the effects of 100 ng/ml IL-6 were evaluated at 30 min, 1 h, 6 h, 12 h, 24 h, and up to 48 h (n = 3 for each time point). The amiloride-sensitive Ieq remained unchanged at 30 min, 1 h, and 6 h (P > 0.05). At 24 and 48 h, amiloride-sensitive Ieq was decreased up to 42% (P = 0.001) and 56% (P = 0.04), respectively. However, at 12 h, the amiloride-sensitive Ieq significantly increased (Fig. 3). As such, in the following experiments, M-1 cells were treated with IL-6 at 100 ng/ml for 12 h.
Amiloride, an ENaC inhibitor at a concentration of 10 μmol/l, almost completely abolished Ieq. Conversely, aldosterone (1 μmol/l) increased the amiloride-sensitive Ieq by 66 ± 5%. The aldosterone-induced Ieq was inhibited by 31 ± 4% by aprotinin (28 μg/ml), a prostasin inhibitor. The amiloride-sensitive Ieq increased by 37 ± 5%, from 6.0 ± 0.4 to 8.2 ± 0.3 μA/cm2 (P < 0.01), in the cells treated with IL-6 (100 ng/ml) compared with controls. Amiloride almost completely inhibited IL-6-induced Ieq, and IL-6 did not counterbalance the inhibitory effect of amiloride on Ieq (Fig. 3). After 12 h of incubation, aprotinin (28 μg/ml), a prostasin inhibitor, reduced the amiloride-sensitive Ieq by 61 ± 5%, from 6.4 ± 0.2 to 3.4 ± 0.3 μA/cm2 (P < 0.01), by reducing Rte and Vte (Table 1). In contrast, IL-6 did not alter Rte but increased Vte from 8.4 ± 0.2 to 12.3 ± 0.8 mV and, in turn, increased Ieq. The magnitude of the IL-6-induced amiloride-sensitive Ieq in the presence of aprotinin dropped by 57 ± 2%, from 8.4 ± 0.2 to 4.9 ± 0.2 μA/cm2 (P < 0.01). Furthermore, IL-6 did not alter the amiloride-sensitive Ieq in the cells pretreated with aprotinin (Fig. 4).
The present study is one of the first to examine the distal tubular effects of IL-6, and the major finding is that exogenous IL-6 appears to augment ENaC expression and activity in M-1 CCD cells in vitro. M-1 cells treated with IL-6 exhibit an increase in the mRNA and protein levels of ENaC subunits and prostasin. The significant increase in Ieq in response to IL-6 is abolished by amiloride, indicating that the electrophysiological induction likely is of ENaC origin. Furthermore, the IL-6 induced Ieq is aprotinin-sensitive, suggesting that prostasin could contribute to the IL-6-related ENaC pathway. Our data imply that IL-6 might play a key role in sodium handling in the kidney through coordinated regulation of ENaC and serine proteases such as prostasin.
Physiological stimuli for the synthesis of IL-6 include norepinepherine, ANG II, other cytokines, and even IL-6 itself (62). Whether IL-6 originates locally or systemically, IL-6 is the main circulating cytokine in linking systemic inflammation with local pathology (43). High salt intake, aldosterone, and ANG II have been shown to increase circulatory IL-6 level in Dahl-salt sensitive rats, hypertensive rats, diabetic rats, and normotensive humans (7, 36, 53, 57). High circulating levels of IL-6 have been correlated with increased blood pressure in spontaneously hypertensive rats and apparently healthy men and might be an independent risk factor for future myocardial infarction in humans (5, 11, 45, 50). It was suggested that IL-6 could be a determinant of diastolic blood pressure in children with obesity-related hypertension (21). Our results suggest that IL-6 might impair natriuresis via ENaC activation, which could partly contribute to salt sensitivity in subclinical inflammatory conditions such as diabetes, obesity, hypertension, and kidney diseases.
Inflammation and proinflammatory cytokines have been demonstrated to affect the function of ENaC. Transforming growth factor-β1 (TGF-β1) was shown to antagonize the action of aldosterone on sodium transport by the rat inner medullary collecting ducts in primary cell culture (27, 54). Specifically, TGF-β1 decreased the endogenous prostasin mRNA and protein expression by 50 ± 12% and 44 ± 12%, respectively, and the amiloride-sensitive 22Na uptake by 35.9 ± 4.8% in cultured M-1 cells, in which the IκBα and NF-κB/Rel signaling system might be involved (58). In another independent study, the TGF-β-induced reduction of amiloride-sensitive Ieq was alleviated in the NH2-terminal-truncated Smad4-overexpressed M1 cells, suggesting that TGF-β1 may decrease the ENaC functionality via a Smad4-dependent pathway (12). Wakida et al. (65) demonstrated that treatment of M-1 cells with TGF-β1 significantly increased the protein expression of protease nexin-1, an endogenous serine protease inhibitor of prostasin. Data on tumor necrosis factor (TNF)-α, however, have been inconsistent. In rats with streptozotocin-induced diabetes, DiPetrillo et al. (15, 17) showed that TNF-α stimulated sodium uptake in the distal tubule cells, providing a possible mechanism for TNF-induced sodium retention and early diabetic nephropathy. Furthermore, while TNF altered distal tubule sodium transport chronically and acutely, chronic TNF exposure led to distal tubule sensitization that permitted acute TNF-induced activation of ENaC in diabetic rats (16). On the contrary, in cultured A6 distal nephron cells, inhibition of ENaC by TNF-α was mediated by ceramide through protein kinase C (2). The mRNA expressions of α-ENaC, β-ENaC, and γ-ENaC were depressed after treatment of mice and cultured M-1 cells with TNF-α and IL-1β, respectively (52). Interferon-γ also altered ENaC function in vitro and in vivo (52). Furthermore, lipopolysaccharide-induced downregulation of ENaC expression was inhibited in knockout mice with a deficiency for TNF-α, IL-1 receptor-1, or interferon-γ. In addition, TNF-α and IL-1β inhibited electrogenic sodium absorption in rat distal colon by mRNA expression regulation of β-ENaC and γ-ENaC (3). The effects of IL-2, IL-4, and IL-13 on sodium absorption, possibly via ENaC, were also shown in colon or bronchial epithelium (4, 20), although their impact on renal ENaC has not been studied. Masilamani et al. (37) demonstrated that elevated circulating aldosterone (due to dietary salt restriction or aldosterone infusion) markedly increased the abundance of α-ENaC protein without increasing the abundance of β-ENaC and γ-ENaC. In the present study, the responses of the gene and protein expression of ENaC subunits to IL-6 also seem to be heterogeneous, although they could be attributable to antibodies from different commercial sources in terms of the Western blot data. IL-6 consistently and markedly enhanced the mRNA and protein expression of β-ENaC, but the increase in the protein expression of γ-ENaC and α-ENaC was relatively small. IL-6 did not alter the gene expression of α-ENaC. The increase in the gene and protein expression of prostasin was also marginal, such that the biological impact of these subtle changes is in question. The aldosterone-induced Ieq (66 ± 5%) was more than twice as high as the IL-6-induced Ieq (37 ± 5%), suggesting that aldosterone is a more powerful ENaC regulator than is IL-6. Unlike aprotinin, IL-6 did not seem to inhibit the Rte. Instead, treatment with IL-6 resulted in the increment of voltage and, subsequently, the elevation of Ieq, indicating that IL-6 might interact with ENaC to increase amiloride-sensitive sodium current. More than half (57 ± 2%) of the IL-6-induced Ieq was reduced by the inhibition of aprotinin, indicating that the stimulatory effect of IL-6 on ENaC activity involves the proteolytic processing. However, cautions are needed in the data interpretation, because aprotinin, also known as bovine pancreatic trypsin inhibitor, is a nonspecific inhibitor of prostasin (69). Several other serine proteases, such as kallikrein and trypsin, are also inhibited by aprotinin, so that other serine proteases may be induced by IL-6. The involvement of prostasin in the IL-6-ENaC conduit needs to be further studied in vitro and in vivo. It is likely that IL-6 could affect ENaC via signal transduction pathways, such as the NF-κB cascade (66, 32), which may be also involved in prostasin activity (58, 65). Furthermore, our data with a single dose (100 ng/ml) at a single time point (12 h) need to be interpreted with caution. In addition, we did not separate the immature from the mature form of the ENaC subunits, which is another limitation, since channel processing and trafficking may play an important role in the response of ENaC to the stimuli in the kidney (22, 23).
We speculate that, apart from ENaC, IL-6 may regulate other renal sodium channels, such as the sodium/hydrogen exchanger (NHE3) and sodium-chloride cotransporter in the proximal tubules, which collectively contribute to the tubular sodium reabsorption. In particular, prostasin is believed to be expressed in the proximal tubules (68) and may affect these sodium transporters.
Perspectives and Significance
Taken together, we have demonstrated that exposure of M-1 cells to IL-6 might upregulate ENaC expression. Exogenous IL-6 increases amiloride-sensitive Ieq in CCD cells in vitro. The present study also envisages the possibility that IL-6 might induce ENaC activation through proteolytic processes, although more mechanistic approaches are required to prove its causal effects. IL-6, a multifunctional cytokine, has been shown to be increased in hypertension, diabetes, and obesity, all of which demonstrate impaired sodium handling. Although further studies are required to fully elucidate the detailed regulatory mechanisms and biological implications of IL-6-induced ENaC activation in cells, animal models, and human subjects, our data could provide a potential mechanism linking sodium homeostasis derangement with chronic subclinical inflammatory conditions, including diabetes and diabetic nephropathy, obesity, hypertension, and kidney disease.
This study was supported by National Heart, Lung, and Blood Institute Grants HL-077230 and HL-085817.
No conflicts of interest, financial or otherwise, are declared by the authors.
- Copyright © 2010 the American Physiological Society
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In the City by the Lake In Two Books, the Shadow and the Slave Girl
Written by Blanche Fearing
Illustrated by
Lovereading4kids Price £17.95In Stock
Delivery time approx. 1 week
In the City by the Lake In Two Books, the Shadow and the Slave Girl by Blanche Fearing
About the Author
Other Formats
Book Info
198 pages
Blanche Fearing
More books by Blanche Fearing
Publication date
21st August 2015
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|By PR Newswire
Article Rating:
|January 16, 2014 11:24 AM EST
CHICAGO, Jan. 16, 2014 /PRNewswire/ -- Sophie's at Saks Fifth Avenue, a new signature restaurant from Fifth Dining, will make its debut in Chicago on the 7th floor of Saks Fifth Avenue's Michigan Avenue store. Sophie's is inspired by American fashion designer Sophie Gimbel, the arbiter of style for Saks for nearly 40 years. Two Chicago restaurant veterans, Executive Chef Ron Aleman, formerly of the Fairmont Chicago, and General Manager Michel Gabbud lead the team at Sophie's. Chef Aleman created the Sophie's Chicago menu, along with Sophie's Corporate Executive Chef, Barcelona-born Alexandro Reyes. It will offer globally influenced yet decidedly American cuisine and libations in an intimate and modern setting overlooking Michigan Avenue, perfect for business or social dining.
"Every restaurant needs an inspiration and in Sophie Gimbel, we have found the perfect muse," said Michael Kaufman, president, Fifth Dining, which operates exclusively to serve as the food and beverage partner of iconic retailer Saks Fifth Avenue. "The first American designer to be featured on the cover of Time magazine, Sophie was a savvy businesswoman who also cooked, gardened, and canned her own fruits and vegetables. Moreover, she did this with an unending sense of wit and style, which we honor in the restaurant's menu and design."
Aleman's menu at Sophie's in Chicago will focus on simple ingredients, sourced locally and seasonally whenever possible, to create contemporary American dishes inspired by world flavors. Sophie's seeks to surprise guests with innovative combinations and flavors and present them in a way that is memorable, for late breakfast, lunch, and afternoon and early evening cocktails. Weekend brunch will be added in the spring. The menu includes small plates such as Salt-Crusted Baby Beets with Gorgonzola, Pecan Caramel, Orange and Yuzu Vinaigrette. Scottish Salmon with Cumin Heirloom Carrots, Red Cress with a Carrot-Mascarpone Sauce and a Pasture-Raised Burger with Fries and Sriracha ketchup are two selections among the seasonal entrees, sandwiches and salads. The specially designed cocktail menu will feature smaller bites and sharable plates.
To complement the food, Sophie's mixologists created a beverage menu focusing on fresh, seasonal cocktails and handcrafted sodas, along with a carefully edited wine list featuring a selection of superb wines by the glass. Standout cocktails include the Sophie's Sonnet (Creme de Poete, fresh lemon juice, Imbue Petal & Thorn and Fee's Rhubarb Bitters) and the Bourbon Cherry Sour (Breaking & Entering Bourbon, Luxardo Morlacco Cherry Liqueur, fresh lemon juice and egg white).
Sophie's sits on the 7th floor alongside the new men's store, The Fifth Avenue Man. Guests of the restaurant will be whisked up to the 7th floor via a dedicated express elevator to experience sweeping views of the Magnificent Mile from the sleek, contemporary restaurant, designed by award-winning architect Andre Kikoski. Most recently lauded for the design of The Wright at The Guggenheim, Andre Kikoski Architect is the only firm to win three of the most prestigious hospitality design awards for a single project in a single year: the James Beard Award for Outstanding Restaurant Design; the Gold Key Award for Hospitality Excellence and the Interior Design Magazine Best of Year Award. In describing the design vision for Sophie's Kikoski said, "We sought to engage the fundamental innovation, luxury and cool that is the core of both Sophie Gimbel and Saks Fifth Avenue in a way that is inviting, elegant and chic."
Sophie's is located at 700 N. Michigan Avenue on the 7th floor of Saks Fifth Avenue. Hours of operation are 10am-7pm, Monday-Wednesday; 10am-8pm, Thursday-Saturday, and 11am-7pm on Sunday. For more information or reservations, please visit www.sophies.com or call 312.525.3400.
About Fifth Dining
Fifth Dining LLC, a wholly-owned subsidiary of Centerplate, Inc., one of the nation's largest hospitality companies, operates exclusively to serve as the food and beverage partner of iconic retailer Saks Fifth Avenue. This includes New York City's flagship store, which features the Cafe SFA and SnAKS restaurants. Sophie's at Saks Fifth Avenue is a new destination restaurant launching in select Saks stores beginning in 2014. For more information, please call 203-975-5917.
SOURCE Fifth Dining LLC
Fifty billion connected devices and still no winning protocols standards. HTTP, WebSockets, MQTT, and CoAP seem to be leading in the IoT protocol race at the moment but many more protocols are getting introduced on a regular basis. Each protocol has its pros and cons depending on the nature of the communications. Does there really need to be only one protocol to rule them all? Of course not. In his session at @ThingsExpo, Chris Matthieu, co-founder and CTO of Octoblu, walk you through how Oct...
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DevOps is speeding towards the IT world like a freight train and the hype around it is deafening. There is no reason to be afraid of this change as it is the natural reaction to the agile movement that revolutionized development just a few years ago. By definition, DevOps is the natural alignment of IT performance to business profitability. The relevance of this has yet to be quantified but it has been suggested that the route to the CEO's chair will come from the IT leaders that successfully ma...
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The Internet of Things (IoT), in all its myriad manifestations, has great potential. Much of that potential comes from the evolving data management and analytic (DMA) technologies and processes that allow us to gain insight from all of the IoT data that can be generated and gathered. This potential may never be met as those data sets are tied to specific industry verticals and single markets, with no clear way to use IoT data and sensor analytics to fulfill the hype being given the IoT today.
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@ThingsExpo has been named the Top 5 Most Influential M2M Brand by Onalytica in the 'Machine to Machine: Top 100 Influencers and Brands.' Onalytica analyzed the online debate on M2M by looking at over 85,000 tweets to provide the most influential individuals and brands that drive the discussion. According to Onalytica the "analysis showed a very engaged community with a lot of interactive tweets. The M2M discussion seems to be more fragmented and driven by some of the major brands present in the...
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Traditional on-premises data centers have long been the domain of modern data platforms like Apache Hadoop, meaning companies who build their business on public cloud were challenged to run Big Data processing and analytics at scale. But recent advancements in Hadoop performance, security, and most importantly cloud-native integrations, are giving organizations the ability to truly gain value from all their data. In his session at 19th Cloud Expo, David Tishgart, Director of Product Marketing ...
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The Quantified Economy represents the total global addressable market (TAM) for IoT that, according to a recent IDC report, will grow to an unprecedented $1.3 trillion by 2019. With this the third wave of the Internet-global proliferation of connected devices, appliances and sensors is poised to take off in 2016. In his session at @ThingsExpo, David McLauchlan, CEO and co-founder of Buddy Platform, discussed how the ability to access and analyze the massive volume of streaming data from millio...
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SYS-CON Events announced today that Pulzze Systems will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. Pulzze Systems, Inc. provides infrastructure products for the Internet of Things to enable any connected device and system to carry out matched operations without programming. For more information, visit http://www.pulzzesystems.com.
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AT 37AVH - Nice Boat
525 - Problems: do a search on this forum, there have been a lot of problems with overheating
Welcome aboard!
I am new to this board, but I have been a quest for a while and I am now looking at a new Active Thunder and I was wondering if I could get some feedback on the boat. It is a 37 AVH and I am looking at powering it with 525's and xr drives.
AT 37AVH - Nice Boat
525 - Problems: do a search on this forum, there have been a lot of problems with overheating
Welcome aboard!
Welcome to the board. Thunderdan is the national sales manager (I believe) for AT and owns a 37, Jassman also owns a 37, and there are a number of other 37 owners here on the board. I'd check out the Active Thunder forum (scroll down on the main forum page, in case you didn't see it).
I've been on Fast Forward, a 37 AT with 496 Mags, and it is one heck of a nice ride. Workmanship is first class. If I had the scratch, Active Thunder would be on my short list of possible boats.
Good luck on your search!
You could not build a better boat and package. I know the 525s may have some issues, but I drove a pair in a new 386 Sonic with ITS/XR drives, and it was smooth as silk.
Welcome to the board, our own little severely disfunctional family! We may bicker and dicker, and we may not always agree, but one thing is for sure, we will ALWAYS help each other out! There are a few exceptions to that rule in that some members may have had bad dealings and those people are exposed quickly. Aside from a few bad apples, this is a WONDERFUL bunch of people who are ALWAYS willing to lend a helping hand, and if your boat is down, (which inevitably it will be at some time ) you will always have someone to ride with from OSO! I cannot say enough about the people I have met and been fortunate enough to get to know and even some have become some of my closest friends! Enjoy!
As far as the 37 AVH goes....what an INCREDIBLE peice of machinery, and an even BETTER group of people to work with. I have been fortunate enough to meet and spend time with ActivethunderDan. He is the national marketing and sales Director for AT and I have also spoken in great depth with Pat, the owner of AT. The workmanship on the new boats is impeccable and the follow up service is even better. And you haven't even hit the water yet! I have not been in a better riding, better handling, or faster vee than and AT, and the value for your dollar is exceptional. I would STRONGLY recommend speaking with Dan and he will surely guide you through the process with patience, caring, knowledgeand understanding. I would however be careful with the 525's as was said earlier as there seems to be a problem with cooling issues. Furthermore, you can have custom built engines with the same power and reliability without the super expensive blue paint job. Best wishes and keep us aprised of your progress as you go through this most exciting and rewarding experience.
Active Thunder...EXACTLY LIKE NOTHING ELSE!
Oh, and BTW, if this guy PUDER types and you do not understand what he is saying....NO WORRIES, OSO has been working on a PUDER SPEAK decoding device!
Last edited by Shane; 07-11-2003 at 07:37 AM.
Smart Move!!!!!
Thanks for the information, if there is problems with the 525's who else could I look at for motors. I really like the Active Thunders and want to be able to run well at the Poker Runs.
Thanks again...
85 mph with 500 hp's EFI....can't go wrong with the reliability with this setup
Not sure about how the actual Dollars work out, but you might consider 500 EFI's. I have a new 37 AVH with 500's, XR drives turning stock 32's. I am getting 79 mph @ 4500 rpm. Roughstuff has the same boat with labbed 31's and is getting 83-84. That is a real nice set up.
The reason for the post is, I think you can save some money by buying the 500's and getting the Arizona Speed & Marine upgrade. Should get the boat close to the 525's and save $4,000 or $5,000 and have the peace of mind the 500's provide. You should also gain 2-3 mph.
Not saying this is actually the case, but might be worth investigating.
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text: Local Local & regional news Attendance up at state fair following renovations By Ellen Abbott • Sep 4, 2016 Photo courtesy of NYS Fair The New York State Fair in Syracuse is in its final weekend. Already this year, attendance is up. Motorcycle accident sends teen to Hospital By Porsha Ari • Sep 3, 2016 File Photo / WBFO/AM 970 News A young man is in the hospital after a motorcycle accident in East Concord, NY on Friday night. Traffic measures at Canalside should ease congestion By Chris Jamele • Sep 3, 2016 WBFO File Photo / WBFO News This holiday weekend is expected to be another busy one on Buffalo's downtown waterfront. One killed on Southern Tier crash By Chris Jamele • Sep 3, 2016 Online Screen Grab / WBFO News A two-car crash in Chautauqua County has taken a life. Poloncarz endorses Wallace By Chris Jamele • Sep 3, 2016 WBFO File Photo / WBFO News Erie County Executive Mark Poloncarz has announced his endorsement of Democratic candidate Monica Wallace for the 143rd District Assembly seat. Tentative contracts reached between Catholic Health and workers at three hospitals By Mark Scott • Sep 2, 2016 Photo by Mike Desmond / WBFO News Tentative contract agreements have been reached at three Catholic hospitals in the Buffalo area. Gillibrand pushes for national Women's Suffrage Commission during Buffalo visit By Michael Mroziak • Sep 2, 2016 Patrick Koster, WBFO As the 100th anniversary of the 19th Amendment gets closer, U.S. Senator Kirsten Gillibrand is calling for the creation of a national panel that would provide support to local interests seeking to educate people about the drive for women's voting rights. Listen Listening... / 1:33 WBFO's Michael Mroziak reports. Weekend encampment showcases the "forgotten war" By Patrick Koster • Sep 2, 2016 Old Fort Niagara It's sometimes called "the forgotten war," and this weekend, local residents will have a chance to learn more about the War of 1812 in a unique way. Catholics prepare to celebrate Mother Teresa's sainthood By Michael Mroziak • Sep 2, 2016 CatholicNewsAgency.com/L'Osservatore Romano Her work with the poor and dying of Calcutta, India gained the world's attention. This Sunday, Mother Teresa will officially become a saint in the Roman Catholic Church. The leader of the Diocese of Buffalo reflected on her life's work and its impact. Listen Listening... / 1:45 WBFO's Michael Mroziak reports. Labor Day one of busiest times for Coast Guard By Marian Hetherly • Sep 2, 2016 With more than 150 emergency cases in Lake Erie, Lake Ontario and the St. Lawrence Seaway in August, Buffalo's U.S. Coast Guard is urging safety to those planning to enjoy the water over Labor Day weekend. County's concussion training law takes another hit By Mike Desmond • Sep 2, 2016 The Erie County Legislature is trying again to get it right on concussion training for youth sports coaches. Listen Listening... / 1:23 WBFO's Mike Desmond reports Scajaquada Creek cleanup on fast track By Mike Desmond • Sep 2, 2016 WBFO's Mike Desmond Scajaquada Creek may flow downhill from Buffalo's eastern suburbs, through the city and eventually to the Niagara River. However, the head of Buffalo Niagara Riverkeeper says its condition is moving uphill. Listen Listening... / 1:08 WBFO's Mike Desmond reports Improved Peace Bridge access begins next week By Chris Caya • Sep 2, 2016 WBFO's Chris Caya The days of routing Peace Bridge traffic through Front Park in Buffalo are coming to an end. It's the latest step in the state's $56 million Gateway Connections Improvement project. Listen Listening... / 1:35 WBFO's Chris Caya reports. Another hiker rescued after leaving marked trail By Marian Hetherly • Sep 2, 2016 The Niagara Parks Police High Angle River Team had to be called in to rescue a man from the Niagara Gorge about 5 p.m. Thursday. Parent Network of WNY receives $500,000 federal grant By Michael Mroziak • Sep 1, 2016 Michael Mroziak, WBFO A local agency that assists families of young people with disabilities is receiving a grant from the U.S. Education Department to further its work to increase support and outcomes for eligible students within Buffalo Public Schools. Champion of Underground Railroad history honored at Broderick Park By Mike Desmond • Sep 1, 2016 Mayor Brown's Facebook page With Broderick Park's role in the Underground Railroad often overlooked, Lillion Batchelor made it her mission to highlight the location's historical importance. City officials are recognizing her efforts with the installation of the Lillion Batchelor Contemplative Garden. Listen Listening... / 1:21 WBFO's Mike Desmond reports. Metro changes aimed at modernizing dated system By Mike Desmond • Sep 1, 2016 File photo The NFTA is rolling out major changes in the operation of Metro Bus and Rail as it prepares to go to a new fare collection system and to put in a turnstile system for the subway. After national breaches, how safe are Erie County's voting machines? By Chris Caya • Sep 1, 2016 NYS Board of Elections Could foreign hackers disrupt the upcoming election? The FBI issued an alert after recent attacks on voter databases in two states, but Erie County's system appears safe. Problems with Athenex project prompt changes at state level By Mike Desmond • Sep 1, 2016 There's been a big shakeup in Albany's management of major local economic development projects. Empire State Development has been given control of the construction of the Athenex plants, projects that have been stalled because the state hasn't been paying its bills. Listen Listening... / 1:30 WBFO's Mike Desmond reports. Fire shuts down Board of Elections, 2 Sheriff divisions By Mike Desmond • Sep 1, 2016 Mike Desmond/WBFO News The Erie County Board of Elections is closed today in the wake of a smoky fire in the 134 West Eagle headquarters. Jacobs proposes reform plan that will 'bring Democracy back' to Albany By Chris Caya • Aug 31, 2016 Chris Caya WBFO News State Senate candidate Chris Jacobs is proposing a reform agenda that he says, will "bring Democracy back" to Albany. The plan includes ending Albany's three men in a room culture. Jacobs, a Buffalo Republican says, to get it done he will push for creating a bipartisan "Reform Caucus" of like minded legislators from both the Senate and Assembly. Gas prices trending lower as summer winds down By WBFO Newsroom • Aug 31, 2016 WBFO News file photo It's been a summer of savings for motorists. A new study indicates motorists have spent $18.9 billion less at the pump this summer compared to 2015. Niagara Falls showing signs of improved finances By Mike Desmond • Aug 31, 2016 WBFO News file photo When Niagara Falls goes to borrow $5 million later this year, the city will do so with an improved credit rating. The Wall Street ratings agency Fitch has improved the city's credit rating from triple-B to Triple-B plus. Listen Listening... / 1:15 WBFO's Mike Desmond reports. Poloncarz: Downtown stadium debate is pointless, even following weekend gridlock By Michael Mroziak • Aug 31, 2016 WBFO file photo If last weekend's large crowds and traffic gridlock in downtown Buffalo have some questioning whether it fuels an argument against a proposed downtown football stadium, the Erie County Executive has this suggestion: don't bother, because there's no stadium discussion even happening. Listen Listening... / 1:37 WBFO's Michael Mroziak reports. Terms for county legislators may be extended to four years By Chris Caya • Aug 31, 2016 Erie County residents may get a chance after all to vote on updating the County Charter. That update may include extending the terms for county lawmakers. Listen Listening... / 1:25 WBFO's Chris Caya reports. New campaign seeks to preserve Buffalo's Outer Harbor By Chris Caya • Aug 30, 2016 Chris Caya WBFO News A new coalition has been formed to "preserve and protect" Buffalo's waterfront. Nicole Matteson, Executive Director of 21st Century Park on the Outer Harbor says, the goal is to ensure that the land off Furhmann Boulevard stays in the public trust. Matteson says, the best way to protect it for future generations is dedicate it as parkland. Chronic drunk drivers may face new penalty: vehicle seizure By Mike Desmond • Aug 30, 2016 Mike Desmond/WBFO News It's an approach that is expanding across the state. A driver who faces a second felony DWI conviction, faces the loss of the car. Listen Listening... / 1:24 WBFO's MIke Desmond reports. Ryan's quick stop in Buffalo nets $250,000 for GOP candidates By Mike Desmond • Aug 30, 2016 Mike Desmond/WBFO News House Speaker Paul Ryan had a successful fund-raiser last night, sponsored by Congressman Chris Collins. While he did not speak publicly during the brief visit, he reportedly raised $250,000. Listen Listening... / 1:29 WBFO's Mike Desmond reports. Press Pass: More filming in Buffalo region By Pat Feldballe • Aug 30, 2016 WBFO News file photo August usually marks the time for vacations, and cutting back on work in general, but that's not the case for the Buffalo Niagara Film Commission and out of town film producers who've come to like what Western New York has to offer. Film Commissioner Tim Clark discusses ongoing film production in the Buffalo area with WBFO's Pat Feldballe on this week's edition of Press Pass. Listen Listening... / 3:59 WBFO's Pat Feldballe & Buffalo Niagara Film Commissioner Tim Clark on this week's edition of Press Pass. Canalside working to prevent future traffic jams By Chris Caya • Aug 30, 2016 Chris Caya WBFO News Some changes are on the way to help avoid a repeat of last weekend's massive traffic jam in downtown Buffalo. Listen Listening... / 1:25 WBFO's Chris Caya reports on the changes being made to head off future traffic jams on Buffalo's waterfront. Pages« first ‹ previous … 5 6 7 8 9 10 11 12 13 … next › last »


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World Vision, the Christian charity, has blurred vision when it comes to the Jewish state. Its disgraceful propaganda against Israel is shameful in itself and marks a betrayal of the ideals it claims to uphold
- Blacksmith
It is so hard to find a worthy charity if you are inclined to donate money etc. It is good these kinds of articles get out so the information is out there.
- Millie_Woods
You do more good giving cash to a rubby pushing a shopping cart full of empties than donating to Oxfam, UNICEF or World Vision. You won't get a tax receipt but at least your money is going to someone who needs it.
No plan is perfect. You just have to do the best you can and hope to hell you've made the right decision.
- Blacksmith
I tend to donate cash only and to a charity I have vetted personally with information like in the article above. If you do a credit card your personal info is out there somewhere else. Also if you donate online to a lot of the big charities they keep coming after you.
- Reader
Dalton McGuinty while he was the Ontario Premier used to actively promote them without saying his daughter was in a management position with them.
McGuinty's endorsement was enough for me not to support them, but this puts the nail in the coffin.
- Millie_Woods
You do more good giving cash to a rubby pushing a shopping cart full of empties than donating to Oxfam, UNICEF or World Vision. You won't get a tax receipt but at least your money is going to someone who needs it.
- Millie_Woods
Don't give your money to them
- marty_p
This comment on the original article page said it best;
Anti-Zionism wishes to turn the clock back to a time when the Jewish people did not have its own state, to when it lived at the mercy of Christian and Muslim overlords, to when they could be purged in pogroms at will. Anti-Zionism wishes to disenfranchise the Jews, to return them to exile and deny their fundamental right to self-determination, which is by definition anti-Semitic, since it only targets the Jews.
You know, we get it. We really do. The world hates us Jews and we'd really like nothing better than to live on our own and not have anything to do with the people who hate us. That was one of the reasons in the aftermath of the Holocaust that the State of Israel was founded, to provide a safe haven for the Jewish people and guarantee that no further such attempt to eradicate its existence would come about. So we were granted a thin sliver of land on the eastern end of the Mediterranean Sea, a desert in all but name, devoid of modern technology, agriculture, infrastructure. We turned it into an oasis. Yes, we get it. We were given a tiny state to call our own, but now even that they want to take away.
What do the anti-Zionists want from us? To turn us to the Arabs and Muslims, who'd like to butcher every last one of us, to return us to living at other peoples' mercy again. Well, it won't happen. Never again was the cry after the horrors of the Holocaust and no State of Israel is going to disappear to leave the Jewish people stranded again, victim to the predations of Muslims and Christians, who butchered us before in our thousands and millions and would do it again in a heartbeat, given the chance.
Thanks for posting this BCF. I thought we were with World Vision and I went "Aww shit!" but I checked with my wife and we sponsor a 3rd world kid in central america through Save the Children".
I remember when we we first deciding to. They give you a choice of what part of the world you want to help.
We said Africa? Screw that. They've had enough help and nothing ever improves.
South east asia? Forget it. We have enough moving into our neighborhood.
Here in canada? No way. The little bastards have enough. Not having a PlayStation doesn't make you poor.
We finally settled on central america.
- Melodi Westergren
Rich Stearns is president of World Vision -US. Stearns is a good friend of Jim Wallis. Jim Wallis is a spiritual advisor to Obama. All I needed to know about the World View of World Vision.
- BillyHW
World Vision is dead to me.


text:
Real Housewives' star Marysol Patton, 46, defies her age as she frolics on the beach in skimpy yellow swimwear
Her life has been a bit bumpy of late, so Marysol Patton took some time out for fun in the sun over the weekend.
The 46-year-old Real Housewives Of Miami star appeared to be defiant of age and gravity as she hit Miami Beach on Sunday.
As far as her fabulous physique was concerned, Marysol was holding up well in a yellow cut-out swimsuit accented with twisted orange and red strings at the hips and back.
Fantastic and fancy free: Real Housewives' Marysol Patton squeezed her amazing figure in a cut-out bathing suit to enjoy a day at the beach in Miami on Sunday
That is, until Marysol risked a possible swimsuit malfunction when she decided to do a little dance on the sand.
She didn't seem concerned that her strapless bathing suit came close to revealing a little too much as she waved her arms wide.
Perhaps her mind was on other things, most likely the hunky man who had joined her at the beach.
The recent divorcee's romantic life seems to be on the upswing, as she arrived to the beach hand-in-hand with the new mystery man.
Dancing queen: Marysol had fun dancing on the shore while coming close to a swimwear malfunction
Splash: The 46-year-old reality star enjoyed the autumn waves while showing off her flawless physique
Perhaps the highlight of Marysol's day was when she got to show off her bikini body and give her hunky guy a hug all at once.
While Marysol's attire was just her bathing suit, her beach date was clad in dark swimming trunks and an army-green T-shirt.
Marysol took to the water with no fear, even in that skimpy outfit, while shielding her eyes from the Florida sun behind glamourous shades.
She wore her waist-length hair in a ponytail but seemed not to care at all if it got doused in seawater.
Handsome company: Marysol was joined at the beach by a hunky new man whom she couldn't resist hugging
The Miami native was singing a different tune not too long ago as everything in her life seemed to be going wrong.
Although the public relations executive began the Bravo series as a regular when it debuted in February 2011, she was said to be recently downgraded to recurring 'friend' status.
Then Marysol suffered another blow when her much-loved mother Elsa, 76, underwent brain surgery following an accidental fall at home.
Chin up: Marysol, who has apparently been downgraded to 'friend' status on RHOM, joined her co-stars at the August season three premiere in Las Vegas
As viewers know, 'Mama Elsa' has made many memorable appearances on the reality show.
In late 2012, Marysol she ended her marraige to French businessman Philippe Pautesta-Herder after two years of wedlock.
'I was really, really, really sad the whole time we were filming,' Marysol told Celebuzz in November.
'I was an emotional wreck. My father was sick. My parents had just separated. I was going through a divorce. I was filming. I was running my company. I had a lot on my plate and it was a really hard time for me.'
Mama mia: The reality star suffered a blow when her mother Elsa, pictured with her at the season two premiere in 2012, underwent brain surgery this year
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I am actress, still trying to make my foothold strong in Bollywood. I had made a debut in Bollywood in 2004 but that went unnoticed and I moved on to south industry.
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The multiple twists, double-crosses and leaps in logic are more likely to prompt giggles than gasps, despite the impressive production values and the earnest efforts…
The multiple twists, double-crosses and leaps in logic are more likely to prompt giggles than gasps, despite the impressive production values and the earnest efforts…
An atmospheric take on the haunted house flick that works more with dread and the looming specter of death than the traditional tropes that often…
Roger Ebert on James Ivory's "Howards End".
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
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A review of Criterion's new box set of Guillermo del Toro films.
"Hollywood Is Losing the Race for Ethnic and Gender Inclusion." The L.A. Times' John Horn reports that, despite people of color being honored in awards ceremonies, movie studios still have a hiring problem.
"Even if Hollywood likes to present itself as magnanimous and liberal, its hiring decisions — including jobs handed to women — continue to be demographically constricted, with most work still going to white men. It's not just movies that are an issue. The Directors Guild of America recently found that 73% of all primetime TV episodes were made by Caucasian males, and the Screen Actors Guild concluded that 76% of all leading roles in television and film were given to Caucasians. (Separately, the picture for women of all races is similarly depressing, and yet again no female filmmakers are contending for the directing Oscar.)"
"After Earth: M. Night Shyamalan's pricey sci-fi film may have recouped its budget internationally (not counting the marketing costs) but the high cost contributed to several Sony executives losing their jobs. Estimated Budget: $110 million. Box Office: $243.8 million."
"Another way to think of 'August: Osage County,' which was directed by John Wells and adapted by Tracy Letts from his own play, is as a thespian cage match. Within a circumscribed space, a bunch of unquestionably talented performers is assembled with no instructions other than to top one another. One twitchy confession must be excelled by another. The same with smoldering, sarcastic speeches, explosions of tears, wistful jags of nostalgia and imperious gazes of disgust. It goes without saying that nobody can beat Ms. Streep at this game. Remember Amy Adams in 'Julie and Julia?' Anne Hathaway in 'The Devil Wears Prada?' Anyone at all in 'The Iron Lady?' Of course not. Here Ms. Streep smokes, rants, bites her fingers, slurs her speech and spews obscenities with the gusto of a tornado laying waste to a small town. Julia Roberts, playing Barbara, Beverly's favorite daughter and therefore Violet's rival, tries to hold her own by refusing to smile. She also slaps a face and breaks a plate. It's hardly a fair contest."
"We use emoticons to punctuate tweets or text messages, but did you know that these icons can [maybe sorta] lend insight into where people fall along the autism spectrum? That's the premise of Genevieve Belleveau's Emoji Autism Facial Recognition Therapy, a performance art piece that showed at this year's Emoji Art Show in Manhattan….In it, Belleveau explained how someone who gives a blunt, literal answer to queries might show signs of Asperger's versus someone whose answer is more nuanced. This doesn't mean, of course, that everybody who answers literally can be clinically diagnosed with such a disease, but it allow people to learn more about how it works, and thus cut down on the stigma and misunderstanding that autism sufferers face."
"Let's not even go into the attacks on reproductive freedom or all the violence against women, or even the Aaron Sorkin characters who set your teeth on edge. Let's just talk about the ways pop culture can chip away at the soul, the ways a jokey demonstration of a game or an imaginary Twitter fight or yet another celebrity explaining that she believes in equality but don't call her a feminist or the sound of that song that just wouldn't go away can make a person realize how far we still have to go. There were truly far too many contenders to choose from this year, but these were the sexist lowlights that raised our blood pressure most."
"Minimalist Posters Depicting the Architecture of Movies."
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FFC Seongyong Cho on watching 2006's dystopian thriller "Children of Men" ten years later.
A review of Criterion's new box set of Guillermo del Toro films.
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20% off Art Prints, Tapestries, and Posters. Pretty up your place. Use code PRETTYWALLS
This is one of the watchtowers on Robben Island, the remarkable prison in South Africa.
africa island mandela nelson prison robben south
very sinister and menacing , great shot though
thank you very much David!! It was very sinister!
What an awful place it must have been…..I like the monochrome here Helen.
this works well in B&W … makes it all much more frightening !!
Thankyou both this is exactly the reaction I wanted from people. I want them to think.
Interesting shot
thanks bysilent
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Mind Snares: Alice's Journey - Preview
Alice is a young woman who spends more time at work than with her family. After being involved in a car accident she finds herself a patient of the mysterious Hospital. Join Alice as she travels through the complex and intriguing pathways of her mind. Find yourself transported to mythical worlds, meeting their unique inhabitants on the way. Learn with Alice what really matters in this contemporary, materialistic world.
Travel through amazing worlds to save yourself before it's too late in this upcoming HOPA from World-Loom!
The full game has been officially released, read the Review or get the game now!


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About Me
CurrentSUNY Canton
MajorCivil And Environmental Technology
Hometownof Mexico, NY
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SUNY Canton is Northern New York's premier college for career-driven bachelor's degrees, associate degrees and certificate programs. The college delivers quality hands-on programs in engineering technology, health, management and public service. Facult...
CollegeSUNY Canton
LocationCanton, NY
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Dusten Wells of Mexico Named to Dean's List at SUNY CantonDusten S. Wells a SUNY Canton Civil and Environmental Technology major from Mexico, NY (13114) made Dean's List for the fall 2013 semester. Wells is a 2006 graduate of Mexico Academy and Central Sc...Fall 2013Verified by SUNY CantonExpand ▾
Ranked #21 among national public universities, Clemson University is a major, land-grant, science- and engineering-oriented research university that maintains a strong commitment to teaching and student success. Clemson is an inclusive, student-centere...
CollegeClemson University
LocationClemson, SC
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Colleges across the country are recognizing students from Mexico High School for their on-campus success. Click any achievement to discover alumni from Mexico High School, view their personalized Merit pages, and learn about what they are accomplishing.
High SchoolMexico High School
TypeOther High School (9-12)
LocationMexico, NY
- Verified by Mexico High School
Activities & Affiliations
Dusten Wells of Mexico Among SUNY Canton Students to Take Eighth in National Steel Bridge CompetitionSUNY Canton's student chapter of the American Society of Civil Engineers (ASCE) placed eighth in the nation with their economical and efficient steel bridge. The College was one of 47 teams to part...Spring 2012Verified by SUNY CantonExpand ▾
Dusten Wells of Mexico Participating in National Student Steel Bridge Competition at Clemson UniversityDusten Wells of Mexico is participating in the National Student Steel Bridge Competition May 25 and 26 at Clemson University. Wells is a member of SUNY Canton's steel bridge team. More than 50...Spring 2012Verified by Clemson UniversityExpand ▾
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Fox host apologises for mocking Ledger death
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Thanks Fox News, but a bit late, don't you think.My subscription is cancelled and will get my news elsewhere.I hope others follow suit and show that we will not tolerate being mocked without repercussions.It was definitely done in bad taste and should have been corrected sooner.
Quite right Omar,Fox is the by word for crass,cruel and tasteless and this moron Gibson sounds the perfect employee.Are there any lengths that Fox will not stoop to. The only factor preventing them from totally going all out down and dirty are the commercial ramifications here.If it hurts or looks like hurting profits then they apologize .It was the same with the OJ Simpson shambles.Fox is such a blight on the world.
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61 Rue Principale
Gatineau, QC J9H 3L4
Be the first Weblocal.ca user to add photos or videos of Club 61 D'Aylmer
This place is not great, but it is not bad either. It has some quirky charm to it. I liked the food, which was fresh and tasty and I liked the cocktail I had. I will probably visit again.


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The Patriots were forced to move offsite Monday with lingering power outages at Gillette Stadium.
That move caused the Patriots to call an audible in regards to their media availability. The team is now expected to conduct a series of conference calls later this afternoon with coach Bill Belichick and a handful of players.


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"Mt. Yotei", also called as "Ezo Fuji" is in this area. Mt. Yotei shows us various expressions spring, summer, fall and winter and known as the of Hokkaido.
There are many mountains such as Annupuri, Niseko Chisenupuri, and Niseko Iwaonupuri, so called as " St. Moritz of the Orient".
The mountains of other Annupuri, Niseko Chisenupuri, such as Niseko Iwaonupuri also concatenation, this area is also known as the "St. Moritz of the Orient". The Rusutsu Resort and Niseko Mountain Resort Grand Hirafu, a lot of tourists from home and abroad gather for powder snow in the winter every year. Read more
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Is this really Japan!? "NISEKO SUPERMARKET & DELI"
know see Kucchan, Niseko, Rusutsu
"FUNABA FARM" - Delicious farm fresh deli and café in Kyogoku Town.
Kucchan, Niseko, Rusutsu see
Man-made heaven – The garden of Kazuo Mishima
Kucchan, Niseko, Rusutsu see
"Reflections of Beauty in Hokkaido"
Kucchan, Niseko, Rusutsu see
Skiing in May /June ?! – A day of Skiing and barbeque at Nakayama Toge
Kucchan, Niseko, Rusutsu see
Sculpted from snow: Snow Lounge @ The Flame - Hilton Niseko Village
Kucchan, Niseko, Rusutsu see
Burning fields in a golden landscape.
Kucchan, Niseko, Rusutsu see
"Good Morning Mt. Yotei!"
Kucchan, Niseko, Rusutsu see
Mt. Yotei on a sunny autumn day.
Kucchan, Niseko, Rusutsu see
"Rolled Hay Bale in the Sun"
Kucchan, Niseko, Rusutsu see
"Journey on a Niseko Steam Train" - Marvel at beautiful autumn colors.
Kucchan, Niseko, Rusutsu see
A sea of clouds surrounds the peak of Mt. Yotei
Kucchan, Niseko, Rusutsu see
'a-ge-i-mo': Super delicious battered deep fried potatoes
Kucchan, Niseko, Rusutsu see
Niseko, Shinsen-numa Wetlands.
Kucchan, Niseko, Rusutsu see
Kucchan, Niseko, Rusutsu
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