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|By Business Wire
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|February 13, 2013 04:01 AM EST
Ubiquisys, the developer of intelligent multi-mode small cells, and Quortus, the company transforming core network functionality into edge-based applications, today announced that they will demonstrate a small-cell-based mobile PBX at Mobile World Congress. The companies will show a Ubiquisys enterprise smart cell loaded with Quortus' EdgeCentrix software to create an all-mobile PBX for businesses, eliminating the need for desk phones as well as giving operators a compelling offering for the underserved small and medium business (SMB) segment.
The solution comprises a Ubiquisys enterprise smart cell – complete with an integrated computing platform based on Intel® architecture – with Quortus' EdgeCentrix application which allows core network functionality to be handled locally. When combined, they create a simple yet powerful all-mobile PBX capable of handling all local voice and data requests. Furthermore, any mobile phone will be able to access the same features as an IP desk phone such as conference calling, call transfer, dual ringing, find-me services and hunt-groups without installing a downloaded client to the handset. The application is distributed and remotely provisioned on smart cells through the Intel AppUp® SMB Service, which is built on the Intel Hybrid Cloud software platform, that enables service providers to deliver the benefits of cloud computing on distributed networked devices.
For businesses, this means they can now replace their existing fixed-line PBX and have a truly mobile workforce. With dependable 5-bar in-building signal matching fixed lines for call quality, employees are able to use their own mobile phone instead of their desk phone, improving workforce productivity and user satisfaction. When making calls, a user always dials the same number from their contact list, and if the target user is also within the coverage area of the office smart cell, the call is routed locally on the cell without touching the macro network. If the target user is outside the smart cell's range then the call goes to the macro network as usual. This creates a seamless experience for the end-user with the added benefit of optimal-cost routing of calls for enterprises.
For operators and MVNOs, this represents a chance to tap in to the enterprise market, especially the SMB segment. This flexible solution makes the most of existing technologies, is easy to install and requires no complex core billing system changes.
"The mobile phone has become the preferred connection for the majority of communication. However, poor in-building mobile coverage and the lack of the functions offered by the traditional PBX have prevented mobile being their preferred method for the enterprise," said Pete Keevill, Vice President of Engineering and co-founder of Ubiquisys. "Our Smart Cell not only ensures reliable coverage but provides the computing power to deliver advanced functions and applications. As enterprise small cell deployments continue to accelerate, I believe we will see mobile form the basis of many forward-thinking companies' communications in the not so distant-future."
"Operators have always faced challenges in targeting the enterprise market and have, to date, failed to break the fixed-line monopoly," said Andy Odgers, CEO Quortus. "By taking network intelligence and placing it on enterprise small cells we can now give every office its own self-contained mobile network that provides a seamless experience for end-users. I expect this technology will be the key to creating a truly mobile workforce."
Ubiquisys and Quortus will be demonstrating their joint solution at Mobile World Congress in Barcelona on February 25–28, 2013. The Ubiquisys meeting and demo suite is located in Hall 1 - contact [email protected] to request a meeting.
About Ubiquisys
Ubiquisys is a leader in intelligent multi-mode LTE-HSPA-WiFi small cells, with products deployed by operators around the world.
The Ubiquisys difference is intelligence: high-availability small cells that continuously adapt to their surroundings and dynamically interact with their neighbours. Operators benefit from macro-level KPIs, low operating costs and efficient use of spectrum assets, whilst mobile users experience dependable voice and high speed data services. The Ubiquisys small cell range includes public-access hotspots, self-organising networks for enterprise, and modular residential small cells designed for home device integration.
Ubiquisys has pioneered the smart cell: part small cell hotspot, part powerful computing platform. This new class of small cell adds cloud and core networking capabilities at the edge of the network, bringing new services closer to mobile users. www.ubiquisys.com
About Quortus
Quortus is changing the nature of mobile networks by allowing operators to embed full core network functionality into cost-effective software applications deployable on small cells. These ultra-smart small cells can be deployed in enterprises, metro hotspots and rural areas where they act as complete mobile networks thereby drastically easing the load on the traditional network and transforming the user experience. For the first time advanced network features can be handled at the edge including smart voice and data offload; session creation, switching & handoff; traffic compression & aggregation; and edge caching & presence information for mobile apps. The company is headquartered in the UK.
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Portal is a tiny town located in the state of Georgia. With a population of 620 people and just one neighborhood, Portal is the 368th largest community in Georgia.
Occupations and Workforce
Unlike some towns where white-collar or blue-collar occupations dominate the local economy, Portal is neither predominantly one nor the other. Instead, it has a mixed workforce of both white- and blue-collar jobs. Overall, Portal is a town of service providers, professionals and sales and office workers. There are especially a lot of people living in Portal who work in sales jobs (11.24%), maintenance occupations (8.61%) and teaching (8.24%).
Setting & Lifestyle
Residents will find that the town is relatively quiet. This is because it is not over-populated, and it has fewer college students, renters, and young children - all of whom can be noisy at times. So, if you're looking for a relatively peaceful place to live, Portal is worth considering.

subset: commoncrawl


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Large 4 bedrooms, 2 full + 2 half baths, family room with wood burning fireplace and walk out to large deck. Eat in kitchen, formal dining room and formal living room. Large master retreat with adjoining bath and walk in closet. Study, recreation room and half bath in the lower level. Ample closets and storage. Convenient location.


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It has been shown that exercise is helpful against brain disorders. However, this may not be true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical condition, it is essential to know the effects of IE on cognitive process because it may have important consequences on people skills and work skills. We investigated the effects of IE on male C57Bl/6 mice, 3-mo-old, undergoing 10 days of intense and exhaustive running program on cognition and its possible relationship with brain oxidative stress. Cognition was evaluated by three different cognitive tests: passive avoidance task, contextual fear conditioning, and tone fear conditioning, performed 24 h after the last exercise session. Brain oxidative stress was evaluated by lipid peroxidation and protein oxidation. There was a remarkable memory reduction of exercised animals in comparison with the control group, associated with increase in the brain oxidative stress, with no alterations in shock sensitivity, locomotion and anxiety parameters. Concurrent vitamin C and E supplementation fully prevented the memory decrement induced by IE and partially recovered both the increased the brain lipid peroxidation and the protein oxidation. In conclusion, IE-induces a high index of brain oxidative stress and impairs memory in murine model that was prevented by vitamin C and E supplementation.
Exercise training is recognized by physicians and medical associations as an important strategy to counteract the risk factors related to neurodegenerative and chronic diseases (Warburton et al. 2006). It has been shown that either enforced or voluntary moderate exercise is a helpful tool against brain disorders, such as depression and anxiety (Goodwin 2003; Petrovitch and White 2005), as it has beneficial effects on cognitive functions (Gomez-Pinilla et al. 2002). Indeed it has been reported that chronic voluntary exercise improves murine performance on the one-trail passive avoidance task (Samorajski et al. 1985), whereas long periods of voluntary exercise increases acquisition rate of spatial learning on an eight-arm radial maze (Anderson et al. 2000) and enforced moderate exercise improves spatial learning in a water maze (Ang et al. 2006). In addition, exercise can enhance neurogenesis (Pereira et al. 2007) and upregulate the expression of trophic factors, which are associated with enhanced memory and long-term potentiation (van Praag et al. 1999; Vaynman et al. 2003).
The same does not certainly stand for intense exercise (IE), which can be drastically injurious according to the subject's physical fitness (Peijie et al. 2003). In fact, this kind of exercise generates high levels of reactive oxygen species, leading to oxidative damage of important macromolecules (Aguiló et al. 2005). Although moderate exercise causes adaptation of brain antioxidant and repair systems by increasing its resistance to oxidative stress (Radák et al. 2001; Somani and Husain 1997), acute and IE seems to enhance its lipid peroxidation (Hara et al. 1997; Somani et al. 1996). However, the effects of IE on either oxidative damage or antioxidant status of the brain are still conflicting, and some authors did not observe exercise-induced alterations in the brain lipid peroxidation or in the antioxidant enzymes activities (Acikgoz et al. 2006; Özkaya et al. 2002).
Considering that it is quite easy to misjudge the appropriate intensity of the daily exercise session with the individual level of physical conditioning, it is essential to unravel the interference of IE on cognitive process as it may have important consequences on people skills and work skills. As observations in humans are difficult to interpret because they can be influenced by the subject's expectancy of exercise-induced either positive or negative effects (Hogervorst et al. 1996), we investigated the effects of IE on the memory of animals supplemented or not with vitamins E and C, to explore the possible relationship between exercise-induced brain oxidative damage and exercise-induced memory impairment.
Inbred male C57BL/6 mice, 28 ± 2 g, were obtained from Centro de Desenvolvimento de Modelos Experimentais para Medicina e Biologia—Universidade Federal de São Paulo animal facility, housed five animals per cage with water and food ad libitum. Animals were kept on a 12:12-h light-dark cycle (06:00–18:00 h) and maintained at 23°C for ≥5 days before any experimental procedure. Animals were divided in four groups: sedentary (control), submitted to IE for 10 days (Ex. 10D), supplemented sedentary (control-V), and supplemented exercised (Ex. 10D-V). Animal-handling procedures were approved by our University Ethics Committee in adherence to the International Guiding Principles for Biomedical Research Involving Animals. Independent animal groups, experimental and the corresponding control, were used for each cognitive test, except for shock sensitivity which was performed immediately after the elevated plus maze test.
Exercise protocol
Animals were submitted to treadmill (Exer 3/6 Treadmill, Columbus Instruments, Columbus, OH)-enforced running, a kind of exercise in which intensity and duration can be easily manipulated and quantified as opposed to voluntary wheel or swimming exercises (Cunliffe-Beamer and Les 1987). Animals from all groups were initially acclimated to treadmill environment by performing a daily running session at 10 m/min for 15 min during five successive days (adaptation period). After this period, the individual maximum velocity was determined by submitting each animal to an incremental test (IT 1), which consisted of 3-min warm-up at 5 m/min, then adjustment of the treadmill speed at 10 m/min, followed by steps of 1 min with progressive increases of 1 m/min until the animal reached exhaustion, terminating in a 3-min cool down at 5 m/min. The exercised animal groups started the training exercise program 24 h after the IT, and each daily session consisted of a single IE session during 10 consecutive days, according to the following schedule: 1) 3-min warm-up at 5 m/min; 2) running at 85% of the individual maximum velocity until animal reached exhaustion; and 3) 3-min cool down at 5 m/min. The treadmill grade was maintained at 0% throughout the adaptation period, the daily exercise training session, and in two ITs as well. Mice were motivated to run with gentle hand prodding. Electrical shock was avoided as a negative reinforcement because this would add undue stress to the animals not typically associated with exercise. Control animals were exposed to the same environment conditions (handling, treadmill motor noise, vibration, and deprivation of food and water), whereas the other animals performed their daily exercise session.
Training intensity markers
Physical performance was assessed by determining the maximum treadmill velocity reached by each animal in the incremental test. Each animal performed two ITs, the first, 24 h after the last day of the adaptation period (IT 1) and the second, either 36 h after the last day of exercise training session or 12 h before the performance of the cognitive tests (IT 2).
Blood samples (25 μl) were collected from the caudal vein of the animals at rest, immediately after IT 1, and at the 10th day of training. Blood samples were stored in 50 μl 1% natrium fluoride and frozen at −20°C. Blood lactate concentration was measured in a lactate analyzer (YSI Model 1500 Sport Lactate Analyzer, YSI) according to the producer's technical specifications.
Supplemented animal groups were simultaneously supplemented with 10 mg/kg vitamin E and 10 mg/kg vitamin C (Faria et al. 2005), once a day and 2 h before the beginning of the exercise session. The vitamin supplementation was administered intraperitoneally, in volumes not exceeding 1 ml/kg body wt. The treatment started at the first day of the adaptation period and finished at the last exercise session, thus summing up a whole period of 16 days of vitamin supplementation. Control animals were daily and intraperitoneally injected with the same volume of saline solution.
Behavioral procedures
Memory performance was assessed by the level of the animal performance in the inhibitory avoidance task done 24 h after the last exercise training session. The avoidance apparatus consisted of a white and a black (light and dark) compartment, separated by a sliding door, with a controlled shock generator connected to the floor, which consisted of a metal grid with the bars 1.0 cm apart from each other. The inhibitory avoidance task included two sessions: the acquisition training and the retention test. In the acquisition training, each animal was placed inside the white compartment of the avoidance apparatus for 10 s with the sliding door closed. Then the sliding door was opened, and as soon as the animal got into the black compartment with all four paws, the door was closed again and three foot shocks (0.5 mA/1 s at each 30 s) were delivered. The time interval elapsed between the opening of the sliding door and the moment the animal got into the black compartment with its four paws corresponds to the latency time. Fifteen seconds after the last foot shock, the animal was removed from the apparatus and kept in the homecage for 30 min before being submitted to the retention test. The procedure of the retention test was exactly the same as that described for the acquisition training but without the foot shock delivery, and the animal was removed as soon as it got into the black compartment (4 paws in). The latency time was recorded as described before, and the higher this value, the better the animal memory performance. A maximum latency time of 180 s was ascribed to the animals that did not get into the black compartment.
The tasks were performed according to Ferreira et al. (2003) with some modifications. These two tasks also comprised two sessions, the acquisition training and the retention test. The acquisition training procedure was the same for both CFC and TFC tasks and was performed 24 h after the last exercise session. Each animal was confined in the black compartment of the avoidance apparatus with the sliding door closed for 3 min when a 60-dB tone was sounded for 5 s. In the last second of the tone, a foot shock (0.5 mA, and 1-s duration) was simultaneously delivered so that both stimuli, electrical and sound, ended at the same time. This procedure was repeated five times at 25-s intervals. Then, the animal was removed from the avoidance apparatus 30 s after the fifth foot shock and returned to its homecage, so that the whole acquisition procedure lasted 5.5 min. After 30 min of rest, the animal was exposed to the same training context to perform the CFC retention test; that is, it was placed again in the dark compartment of the avoidance apparatus, but this time no foot shock was delivered. The freezing time, defined as the period of time the animal remained fully motionless with no evident signs of vibrissa movements and sniffing, was continuously recorded minute by minute for 5.0 min by a skilled observer. The TFC retention test was performed 24 h after its respective acquisition training and 48 h after the last exercise session. Mice were placed in a new context (i.e., the white compartment) for 5.0 min with the sliding door closed. At the end of the third minute, the same tone, utilized in the acquisition training, was delivered five times at 25-s intervals, throughout the fourth and fifth minute of exposure to the avoidance apparatus. The freezing time was measured, minute by minute, before and after the tone.
Animal anxiety levels were assessed 24 h after the last exercise session by elevated plus maze (EPM) test. The plus maze apparatus consisted of a cross with two open arms (30 × 7 cm) and two closed arms (30 × 7 cm with a wall 14 cm high), both arms standing at 50 cm above the floor. The animal was placed in the central segment of the EPM apparatus facing one of the open arms. The number of entries into and the time spent either in the open or in the closed arms were recorded for 5 min. The percentage of entries into the open arms was calculated relative to the total entries in either open or closed arm. The apparatus was cleaned with alcohol after the end of each animal performance to avoid any smell interference between distinct animals. The total number of entries was used as a measure of locomotion.
Shock sensitivity test was performed, immediately after EPM test, by placing each animal in the dark compartment of the avoidance apparatus with the sliding door closed. Foot shocks of progressive intensity were delivered, starting at 0.1 mA, followed by increment steps of 0.1 mA at 30-s intervals until the animal either flinched (coordinated movements of paw withdrawal) or vocalized. The intensity of the shock necessary to produce one of these two behaviors was recorded.
Oxidative stress levels
Peroxidative damage to membrane lipid constituents from whole brain was determined by measuring the chromogen reaction product of 2-thiobarbituric acid (TBA) with one of the products of membrane lipid peroxidation, malondialdehyde (MDA), according to the technique described by Winterbourn et al. (1985) and adapted by Rosa et al. (2005). In brief, homogenate tissue pools were incubated for 30 min with the reaction mixture at 95°C. The chromogen reaction product was extracted in n-butanol, and its concentration was determined spectrophotometrically (N-200, Hitashi, Tokyo, Japan) at 532 nm. Results are expressed as nanomoles per milliliter per gram dry tissue.
Oxidative damage to whole brain proteins was spectrophotometrically determined by quantifying tissue carbonyl content according to the method described by Reznick and Packer (1994). Briefly, 10 mM 2,4-dinitrophenylhydrazine (DNPH), dissolved in 2.5 M HCl, was added to brain homogenate pools from each animal group to generate chromophoric dinitrophenylhydrazones. After the DNPH reaction time, proteins were precipitated in 20% (wt/vol) trichloroacetic acid (TCA), followed by successive washings with ethanol/ethyl acetate mixture (1:1) and centrifugation at 6000 g. The last pellet was dissolved in 6 M guanidine–HCl solution. The protein carbonyl content was assessed spectrophotometrically (N-200, Hitashi) at 370 nm, using the molar extinction coefficient of DNPH, ε = 22,000 M−1 cm−1. The total protein content was measured in comparison with a bovine serum albumin standard curve (0.25–2.0 mg/ml) at 280 nm.
The following solutions were used for lipid peroxidation assays: phosphate buffer solution (in mM): 20 KH2PO4, 150 KCl, and 40 HEPES; the reaction mixture: 20 mM phosphate buffer, 11% acetic acid, 0.1% tungstophosphoric acid, 0.5% SDS, and 0.2% TBA. For carbonyl assays the homogenizing buffer solution was: 50 mM NaH2PO4, 0.1% digitonin, plus a cocktail of antiproteases (5 mg/ml leupeptin, 7 mg/ml pepstatin, and 5 mg/ml aprotonin), and 1 mM EDTA.
All chemicals were analytical grade. Salts, d-glucose, n-butanol, TBA, tungstophosphoric acid, SDS, ascorbic acid (vitamin C), and acetic acid were purchased from Merck (Darmstadt, Germany); EDTA, 2,4-dinitrophenylhydrazine, TCA, cocktail of antiproteases, digitonin, guanidine, and α-tocopherol (vitamin E) were from Sigma (St. Louis, MO).
Statistical analysis
Data are presented as means ± SE with n representing the number of experiments. Statistical significance was analyzed by t-test of Student's or ANOVA, followed by Newman-Keuls′s test. P < 0.05 were considered statistically significant.
Training intensity markers
Animal adaptation to the exercise protocol was assessed through two well-known IE markers: the physical performance and the blood lactate concentration (Boudet et al. 2004; Marquezi et al. 2003). After 10 days of IE training, a reduction of 34% in the maximum velocity reached by the exercised animals in the IT2 as compared with IT1 was observed (Table 1). Consistent with the high-intensity training, great accumulation of lactate in the exercised animal blood throughout the IE period was detected, starting from 2 mM before the training initiation (control) ≤5 mM after the IT1, and reaching values >6 mM after the 10th day of IE (Table 1).
Inhibitory avoidance task
Data from the acquisition training of IAT were analyzed considering two factors: supplementation (saline or vitamin) and exercise (control or exercised). Neither supplementation [F(1,29) = 0.13, P = 0.72] nor exercise [F(1,29) = 0.19, P = 0.66] caused any significant effects on the latency time, and no interaction between supplementation and exercise [F(1,29) = 1.55, P = 0.22] animal groups was detected by two-way ANOVA analysis.
Concerning the retention test from IAT, a significant effect of supplementation [F(1,29) = 4.28, P < 0.05] and exercise [F(1,29) = 4.31, P < 0.05] with a significant interaction between them [F(1,29) = 4.74, P < 0.01], were detected by two-way ANOVA analysis. Thus intense and exhaustive exercise caused a significant decrease of 41% in the latency time in the exercised group as compared with the control. This reduction was fully prevented by concurrent vitamin C and E supplementation (Fig. 1A).
CFC and TFC acquisition training
Data from the acquisition training from CFC and TFC tests were analyzed considering three factors: first, supplementation (saline or vitamins), second, exercise (control or exercised), and third, time (minute). A significant effect of time (minute) [F(3,105) = 47.02, P < 0.001] was detected in the three-way ANOVA analysis done with measurements of freezing time (s) at 1-min intervals (data not shown), but no effect of either supplementation [F(1,35) = 1.43, P = 0.23] or exercise [F(1,35) = 0.15, P = 0.69; Fig. 1B]). In addition, no interaction between supplementation and exercise, minute and supplementation, minute and exercise, or even among the three factors [F(1,35) = 0.52, P = 0.47; F(3,105) = 0.38, P = 0.76; F(3,105) = 0.03, P = 0.99; F(3,105) = 0.568, P = 0.63, respectively] were detected. Post hoc analysis (Newman-Keuls, P < 0.05) to time effect detected that mice from all groups presented more freezing behavior during the first minute after tone and shock presentation, than in all other minutes (P < 0.01).
CFC retention test
A significant effect of supplementation [F(1,35) = 6.67, P < 0.05] and exercise [F(1,35) = 17.39, P < 0.001] were detected in the two-way ANOVA. In addition, significant interaction between supplementation and exercise [F(1,35) = 9.48, P < 0.01] was detected. Post hoc analysis considering the interaction between supplementation and exercise factors detected that Ex. 10D group displayed the lowest total freezing time (P < 0.001; Fig. 1B).
TFC retention test
Three-way ANOVA detected significant effect of time (minute) [F(4,140) = 109.93, P < 0.001] but no effect of both the supplementation [F(1,35) = 4.02, P = 0.06] and the exercise [F(1,35) = 1.74, P = 0.19] factors. Significant interaction between minute and supplementation [F(4,140) = 6.02, P < 0.001] and minute and exercise [F(4,140) = 3.41, P < 0.05] and among the three factors [F(4,140) = 6.39, P < 0.001] were detected, in contrast to the absence of any interaction between supplementation and exercise [F(1,35) = 2.39, P = 0.13].
A post hoc test considering the interaction among the three factors detected that no differences were observed among the groups before the tone presentation (minutes 1–3). In contrast, immediately after the tone presentation (minutes 4 and 5), the Ex. 10D displayed the lowest freezing time (P < 0.05). Throughout the test, the control, control-V and Ex. 10D-V animal groups displayed similar freezing behavior. Throughout the second and third minutes, there was a significant increase (P < 0.05) of the freezing time as compared with the first minute, then followed by a significant increase (P < 0.05) immediately after the tone, at the fourth and fifth minutes, when the freezing time reached its highest values. On the other hand, the tone presentation did not alter the animal behavior of animals from Ex. 10D group, as there were no significant differences in the freezing time immediately before or after the tone presentation.
Shock sensitivity
No significant difference between control and Ex. 10D groups (P = 0.52) was detected with the Student's t-test (Fig. 2A).
Elevated plus maze (EPM) test
No differences were detected between the control and Ex. 10D groups concerning the time spent either in the open arms or in the closed arms (Fig. 2B); but for both animal groups, the percent of total permanence time was higher in the closed arms than in the open arms. Moreover, the total number of entries in the open and closed arms, an indicative of locomotion, did not differ between the control and Ex. 10D animal groups (Fig. 2C). Altogether, these results suggest that there were no differences caused by exercise on the anxiety level and locomotor activity of the animals.
Lipid peroxidation assay
Two-way ANOVA detected significant effect of exercise [F(1,12) = 26.81, P < 0.001], supplementation [F(1,12) = 3.34, P < 0.05] and a significant interaction between these two factors [F(1,12) = 3.00, P < 0.05]. Post hoc analysis shows a significant increase of 150% in brain lipid peroxidation level of the Ex. 10D group compared with control group. The vitamin supplementation partially prevented the lipid peroxidation damage since animals from Ex. 10D-V presented a significant decrease of the LP levels compared with those from Ex. 10D group but still remained 60% higher than the LP level from the control-V group (Fig. 3A).
Carbonyl assay
Two-way ANOVA detected significant effect of exercise [F(1,12) = 32.08, P < 0.001] and supplementation [F(1,12) = 42.63, P < 0.001] but no significant interaction between the two factors [F(1,12) = 0.001, P = 0.97]. The Ex. 10D group presented a significant increase of 31% on the protein carbonyl content, whereas the Ex. 10D-V presented the same levels as those from the control group. Finally, the supplementation also reduced the levels of protein carbonyl content in the control animals, as the control-V presented a significant decrease of 6% on the protein oxidation compared with the control group (Fig. 3B).
In the present study, we provide evidence for the negative impact that intense and exhaustive exercise has on mice cognition and its relationship with the exercise-induced oxidative stress of the brain. The cognitive tests consisted of two pavlovian fear conditioning tasks, the CFC, involving hippocampus-dependent pathway, and the TFC, involving hippocampus-independent pathways. The third test was an instrumental conditioning task, the IAT, which is also susceptible to hippocampal lesions (Fornari et al. 2000). Oxidative stress was evaluated by both the membrane lipid peroxidation and the protein oxidation levels of the brain from C57Bl/6 mice engaged in enforced IE training. In all tests performed, there was a significant learning impairment associated with increased oxidative stress in the brain of exercised animals. Both effects were prevented by 16 successive days of concurrent vitamin C (ascorbic acid) and E (α-tocopherol) supplementation of the animals. This is, to our knowledge, the first study to clearly report on relationship between exercise-induced cognitive prejudice and brain oxidative stress.
Our first concern was to characterize as intense the designed exercise protocol, and this was done by determining the effects of exercise protocol on two well-known intensity exercise markers, the blood lactate concentration and the animal physical performance. The blood lactate concentration was >5 mM just after the IT1 and at the end of the exercise program (Table 1). This reference value, according to Billat et al. (2005), indicates that the exercise protocol applied can be classified as intense. Moreover, the observed reduction of 30% of the maximum velocity reached by the animals in the incremental test performed 36 h after the end of the exercise program (IT 2; Table 1) corroborates the high intensity of the exercise program because successive sessions of IE impaired animal physical performance, mainly when the resting period between two sessions was not long enough to allow the complete recovery from the last exercise session (Budgett 1998).
The significant reduction of both the latency time (Fig. 1A) in the IAT, and the total freezing time (Fig. 1B) in the CFC in exercised animals as compared with control animals clearly show that IE impairs hippocampus-dependent memory. This is quite interesting considering that hippocampus is a region of the brain known to be very sensitive to oxidative stress (Jolitha et al. 2006; Parihar and Pandit 2003). Moreover, the negative influence of IE also on hippocampus-independent memory, as assessed by the significant reduction of the freezing time in the TFC task (Fig. 1C), enlarges the influence of this kind of exercise to other areas of the brain. It could be raised the possibility that other intrinsic parameters, such as sensitivity to electrical shock, elevated anxiety level, and locomotion disturbances, might be responsible for the observed impairment of the cognitive test performance. However, these were discarded since both the control and exercised animals did not differ regarding their sensitivity to shock intensity (Fig. 2A), the time of permanence of the animals on the open arm of the EPM (Fig. 2B) and in their locomotor activity (Fig. 2C).
The observation that IE greatly affected all memory tasks, together with its well-known potent stimulus for increased formation of reactive oxygen species (Davies et al. 1982) led us to think that the cognition reduction induced by exercise might be related to brain oxidative stress, mainly because it has been already reported a straight relationship between cognitive impairment and brain oxidative stress (Serrano and Klann 2004). In accordance with these authors, we now demonstrated that the level of oxidative stress in the brain was significantly augmented in exercised animals as compared with control because higher level of both membrane lipid peroxidation and protein oxidation were observed, as assessed by the enhancement of MDA concentration, and accumulation of carbonyl groups in the brain, respectively (Fig. 3, A and B). These results are also in agreement with those from Tsakiris et al. (2006), who reported that either short or prolonged enforced swimming exercise induces oxidative stress in the rat brain. In addition, the exercise-induced brain oxidative stress herein reported was sensitive to the improvement of the antioxidant defense mechanisms of the animals because 16 days of supplementation with both vitamin C and E partially protected the brain from membrane lipid peroxidation and avoided brain protein oxidation (Fig. 3). More interestingly, the vitamin treatment also prevented the decrease in the general memory capacity caused by IE as the latency time, the total freezing time, and the minute-by-minute freezing time in the exercised supplemented animals were similar to those obtained in the control animals, supplemented or not (Fig. 1). These results indicate that both the IE and the vitamin and E supplementation may not be specifically targeted to discrete brain regions, like hippocampus, but may represent more global events. We cannot discard the possibility that the protective effect exerted by vitamin C and E supplementation could be due to other actions beyond the antioxidant effects of both vitamins, such as inhibition of pro-inflammatory cytokine release (Fisher et al. 2004). However, the straight relationship observed between exercise-induced brain oxidative stress and the impairment of cognitive function, on one hand, and the significant recovery of cognitive function and the reduced level of brain oxidative stress in exercised, but supplemented animals, on the other hand, strongly argue in favor of the importance of the antioxidant features of the vitamins C and E. Finally, it should be stressed that according to Faria et al. (2005), the simultaneous treatment with both vitamin C and E was more efficient to attenuate reserpine-induced oral dyskinesia, which is known to be associated with brain oxidative stress, than supplementation with either one of these vitamins.
It might be argued that the impairment of memory in mice submitted to enforced exhaustive and IE could be somehow related to the stress associated with enforced training. In rat model, Diamond et al. (1992) reported that increased level of the hormone corticosterone, >210 ng/ml, prejudices the learning process, while others reported positive effects of enforced moderate exercise on animal cognitive performance (Ang et al. 2006), despite the corticosterone increased level, ∼280 ng/ml, induced by this kind of exercise (Ebal et al. 2007). Although there were no data, as far as we know, concerning the relationship among corticosterone levels, learning process, and exercise in murine model, the conflicting evidences in the literature and the lack of effect of vitamin C and E supplementation on corticosterone secretion related by Armario et al. (1989) allow us to rule out this alternative as an explanation for our results.
In the unique study on animal model about the effect of IE on memory, Ogonovszky et al. (2005) showed the beneficial effects of this kind of exercise. However, this was observed in aged rats (20–28 mo old), an experimental condition greatly favoring oxidative stress of the organism (Harman 1956). According to Tomporowski (2003), the researchers who have examined the effects of IE on human cognitive processes have consistently failed to detect a clear relationship between the exhaustive exercise and the processes involved in perception, sensory, integration, or discrimination. In fact, Hogervorst et al. (1996) demonstrated a positive impact of IE on the subject cognitive performance, but it could be argued that their results could be caused by the expectancy of the subjects for a positive effect of exercise rather than on the intrinsic exercise effect. Whereas Grebot et al. (2003) demonstrated that IE could increase the difficulty of recall shooting performance, Fleury et al. (1981) could not detect any clear influence of IE on a letter-detection task.
Finally, although the clear demonstration of the harmful effects of IE on the cognitive function was done in rodent model, which obviously cannot be directly extended to humans, it raises the important question about its consequences to human brain because it is quite easy for people to exceed their individual lactate threshold while performing exercise leading to significant mismatch between exercise intensity and their physical conditioning.
This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado de São Paulo. E. F. Rosa was on a fellowship from CNPq.
We are grateful to O. G. da Silva and V.L.S. Rigoni for technical assistance.
↵* M.G.M. Oliveira and V.L.A. Nouailhetas contributed equally to this work.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2007 by the American Physiological Society


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June 16, 2015
High-end London lettings agency EJ Harris has trawled through its archive of client-tenant paperwork to draw up a list of things that are most likely to cause friction between landlords and tenants in central London.
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Groove International: The Pirate's Booty Ball
The party production team Groove International takes over the House of Blues as they officially introduce their good-times business into Orange County. Bringing together a wild mix of live bands, DJs, dancers, models and even some "celebrities," these traveling clubs promise a more interactive experience—meaning you won't just be stuck in front of a stage all night. Tonight is the Pirate's Booty Ball—so break out your Comic Con garb a little early, or resurrect that Halloween costume from 2006, the pirate theme is still going strong. Get down in a sea of tri-cornered hats, hoop earrings, corsets and rum drinks—and as Groove International reminds us, "not all treasure is silver and gold, mate."
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The Pier Cafe: "Lovely sea views" The Mumbles Restaurant Tip by Myfanwe
The Mumbles Restaurants: 7 reviews and 22 photos
The Pier Cafe is a spacious cafe where you can call in for just a coffee and a cake or have a meal. It is situated alongside Mumbles seafront right next to the Victorian Pier. The food here is good value - the all day breakfasts are particularly good value and come with a cup of tea thrown in.
Directions: Head towards Mumbles pier and you will see the Pier cafe just before it.
Rating: 4
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Fuck Amazon Cloud Player. Google Music (or I guess Google Play now) is free, and gMusic is $2, and works splendidly.
It's a universal app, so it'll work on the iPad too, and it AirPlays to anything that'll accept it (in my case an AirPort Express at home and at work) so you can stream to speakers.
The app is designed well enough that I don't really care that it's not a "Google" app.


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Federal-Mogul Friction Plans $7 Million Expansion To Plant In Rural South Carolina
The company serves original equipment manufacturers of automotive, aerospace, marine, rail and off-road vehicles, along with industrial, agricultural and power-generation equipment.
In addition the firm's subsidiary, Federal-Mogul Friction Products, develops and manufactures extended-life brake friction products, with noise, vibration and harshness refinement. It is a leading supplier of friction products to original equipment manufacturers.
The expansion is taking place at Federal-Mogul Friction Products, which for the last 16 years has operated its 210,000-square-foot facility with 210 employees in Orangeburg, at 2084 Rowesville Road.
"With this significant investment, we are further cementing our commitment to being a world-class OEM friction supplier," said Alex Lopez, Federal-Mogul Plant Manager.
"It's a great day in South Carolina when one of our existing businesses chooses to grow. We celebrate Federal-Mogul's decision to invest $7 million and create 40 new jobs in Orangeburg. By continuing to strengthen our state's business-friendly climate, we can continue to attract investments like this one to South Carolina," said Gov. Nikki Haley. "South Carolina continues to see its reputation in the automotive club grow.
Federal-Mogul's decision to further invest in the Palmetto State builds on that reputation and shows that our manufacturing sector is continuing to grow," said Secretary of Commerce Bobby Hitt.
"We are excited about the growth of our existing industry. The addition of this industry's jobs and capital investment shows Orangeburg County is a great place to work," said Jeannine Kees, chairwoman of Orangeburg County Development Commission. "This is a significant sign that automotive related industry is coming back."
As part of an incentive package ReadySC, a division of the S.C. Technical College System, in cooperation with Orangeburg Calhoun Technical College, is assisting the firm with the recruitment and training for new Production Technician positions at Federal-Mogul.
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Woodbine backstretch deals with flooding; Tuesday training canceled
ETOBICOKE, Ontario – Woodbine's backstretch was engulfed by 5 inches of rain in a storm that started late Monday afternoon and continued well into the evening.
Several barns were flooded, to varying degrees. The flooding was worse in barns where end doors and windows were left open and employees were unable to get to them due to flooding at the backstretch entrances.
The actual stalls were flooded in a number of barns, and matting and bedding was pulled out and tossed on the shed rows in an attempt to dry them.
The dirt training track was closed Tuesday due to its water-logged condition, and the Polytrack surface was inaccessible due to flooding in the tunnel that the horses use to gain entrance to the surface.
The Woodbine racing office announced that grass races scheduled for Wednesday night had been moved to the main track.
The Canadian Horse Racing Hall of Fame, located at the west end of the grandstand, on the first floor, was flooded, but Tom Cosgrove, co-chairman of the organization's nomination and election committees, said there was no damage to the exhibits.
Last month, Woodbine was compromised by a mini-outbreak of the equine herpesvirus that shut down one barn completely for 10 days beginning June 11 and prevented horses from shipping out until June 26.
One trainer, surveying the situation here Monday, said "First the plague, now the floods – what's next?"
Monday's rainfall was the highest officially recorded in Toronto's history, surpassing even the amount measured when Hurricane Hazel lashed the Greater Toronto Area in 1954.
Monday's rains also followed the 1.6 inches of rain that fell late Sunday afternoon and caused Woodbine's Highlander Stakes to be moved from the turf to the Polytrack on short notice.
More rain, although of a lighter variety, had already fallen Tuesday morning and even more was expected later in the day.
bad karma ?
why so bitter?
This comment has been deleted
Shame the whole place did not wash away.
Some one should call an inquiry, ITS THE CANADIAN WAY!


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Delicious and warming side dish of rich butter beans, leek, bacon, parsley and chicken stock. Makes 2 individual servings.
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I have, along with several classmates, participated in Southern Utah Code Camp two years now, and last year my team took 1st place in the student group. We also competed in the Dixie Coding Competition (I am unsure of the official name) and we won the high school section of that as well.
Taylor Braaten
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Police said an off-duty police officer helped nab a suspect in a shoplifting incident at Dillard's at Hamilton Place Mall.
The officer said he was advised that a black male wearing a yellow jacket and a black ball cap had stolen items from the store.
Store personnel said he took five pairs of Polo pants worth $42 each and two pairs of Amani underwear valued at $32 each.
The officer spotted a man wearing a yellow jacket and a black ball cap and ordered him to stop. He got into a white Pontiac Sunfire, put it into reverse, and drove off.
The officer got the tag number and traced it to a female, who said on the phone that she had loaned the car to her grandson, Oshey Turner.
Police were then able to call up Turrner's photo, and Dillard's personnel identified him as the shoplifter.
Warrants were issued for his arrest.
* * *
Officials of Sears at Northgate Mall said one of the store personnel had been taking cash during transactions.
Madison Nicole Bennett was interviewed and admitted taking some $200 during multiple transactions, it was stated.
She was cited to court.
Two women said they put their purses in the trunk of their car at the Republic Parking Garage on Chestnut Street.
While they were doing so, a white male and white female in their mid-20s in a black Mustang Cobra were watching, they said.
When they returned, the purses were missing.
The man was wearing a white ball cap. The woman had long blonde hair.
October 28, 2016
October 27, 2016
Here is the latest jail booking report from Hamilton County: ADKINS, GREGORY SCOTT 401 EASTERLY CIRCLE ROCKY TOP, 37769 Age at Arrest: 39 years old Arresting Agency: Chattanooga ... (click for more)
Senator Bob Corker on Thursday released the following statement ahead of Affordable Care Act open enrollment, which begins Nov. 1. "The Affordable Care Act was sold to the American ... (click for more)
Special agents from the Tennessee Bureau of Investigation have secured indictments for a Monroe, Tn., couple in connection to an ongoing statutory rape case. At the request of 13th ... (click for more)
Here is the latest jail booking report from Hamilton County: ADKINS, GREGORY SCOTT 401 EASTERLY CIRCLE ROCKY TOP, 37769 Age at Arrest: 39 years old Arresting Agency: Chattanooga Booked for Previous Charges or Other Reason(s) --- BILLS, JOSHUA TIMOTHY-MICHAEL 1309 DUNCAN AVE CHATTANOOGA, 37404 Age at Arrest: 24 years old Arresting Agency: ... (click for more)
Senator Bob Corker on Thursday released the following statement ahead of Affordable Care Act open enrollment, which begins Nov. 1. "The Affordable Care Act was sold to the American people as a way to bring down health care costs and provide certainty to individuals and companies across our country. Unfortunately, the reality Tennesseans will face as open enrollment ... (click for more)
Am I making a difference? Isn't that the basic question we all ask ourselves, and seek to demonstrate to others? Ronald Reagan said: "Some people spend an entire lifetime wondering if they made a difference in the world. But, the Marines don't have that problem." We would argue teachers do not have that problem either. Educators make a huge difference ... (click for more)
Two weeks before the August election where three members of the Hamilton County School Board were angrily replaced, the organizer of what was called "a great way for the (challengers) to raise great money to help them run smart campaigns" made a bold statement. "I'm sure the current board is well-intentioned, but the results are not there," said Paul Brock. "Leadership matters ... (click for more)
MURFREESBORO - The scoring opportunities were few for both teams, but Christ Presbyterian used a shot and a deflection off a defender for a 1-0 win against Chattanooga Christian in an A-AA state semifinal match here Thursday at the Richard Siegel Soccer Complex. District 12 player of the year Sarah Sievertsen scored the winning goal in the 54th minute as the Lions advance ... (click for more)
KNOXVILLE, Tenn. -- Tennessee offensive coordinator Mike DeBord, defensive coordinator Bob Shoop and tight ends coach/special teams coordinator Larry Scott spoke reporters at Wednesday's press conference in the Ray and Lucy Hand Digital Studio. No. 18 Tennessee (5-2, 2-2 SEC) takes on South Carolina (3-4, 1-4 SEC) on Saturday at Williams-Brice ... (click for more)


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Sundowns go top of PSL table after beating Orlando Pirates
Although the hosts were still in a celebratory mood after their Telkom Knockout final win over Kaizer Chiefs on Wednesday night, they started on a low, losing the ball easily.
It was Pirates who threatened first through Menzi Masuku as he received a pass from Kermit Erasmus but the South African under-23 star saw his shot going over the bar.
Despite efforts to break the deadlock, the score remained 0-0 after 10 minutes of action after Khama Billiat hit the side of the net as he tried to beat Siyabonga Mpontshane on his near post.
However, after five more minutes, Sundowns scored when Billiat received a wonderful pass from Keagan Dolly — he made a good run down the left flank and beat Rooi Mahamutsa before laying it up for Castro to finish.
After 30 minutes of action, Pirates looked disjointed and Pitso Mosimane's men had a good chance to double their lead when Asavela Mbekile turned defence into attack, but his delayed pass to Billiat couldn't go through as it was intercepted by Ayanda Gcaba.
In the dying stages of the first half, Pirates pushed forward searching for a goal but Thamsanqa Gabuza's attempt was way off target, and a few minutes later Menzi Masuku's shot went straight to Denis Onyango.
It was 1-0 at half time and the second stanza saw the Brazilians coming back guns blazing, with Dolly taking a good shot, only to see it going over the target.
In the 64th minute, the combination between Billiat and Castro paid dividends as the Zimbabwean winger broke free and converted in the box, beating Mpontshane on his far corner.
As Sundowns continued to pile pressure on their visitors, defender Wayne Arendse found himself unmarked in the box, but he lacked composure as his shot sailed over Mpontshane's goals.
With 10 minutes remaining, Billiat continued with his fine form and made a great run. Mpontshane though read the situation perfectly and the former Platinum Stars man pulled off a great save. In an aim to respond, Mpho Makola saw his shot going straight to Onyango.
In the dying minutes, Pirates failed to get something out of the match, allowing Sundowns to move to the top of the Absa Premiership log standings with 26 points and demote Bidvest Wits to the second spot on goal difference.


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The sequal to 8 mile is going to be called 3 road.
And he's already "retired" from rap.
Ya it's too bad his one and only album sucked so much.
Groovy baby
welcome to 2003
if u have lucky, try to find the 3 other rap contest from before..
ther's three parts to it.
Last edited by scubaphil; 02-21-2006 at 06:09 PM.
If jack helped you off a horse would you help jack off a horse??
You start with a bag full of luck and an empty bag of experience. The trick is to fill the bag of experience before you empty the bag of luck.
I <3 Photography


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The Story of Great Inventions
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Is Klach Courier Services Sdn Bhd incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
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Is Klach Courier Services Sdn Bhd in No. 157, Jalan Maharajalela, Kuala Lumpur Kuala Lumpur 50150 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Shipping services in Kuala Lumpur available on Hotfrog MALAYSIA. You can update your search for Kuala Lumpur Shipping by location, keyword or service options.
No. 56 Jln Kemuja 59000 Kuala Lumpur Wilayah Persekutuan Kuala Lumpur 59000
Kuala Lumpur
Lg Wisma City Tower Jln Alor 50200 Kuala Lumpur Kuala Lumpur Wilayah Persekutuan 50200 Malaysia Kuala Lumpur 50200
No, 34 & 36 Jalan Landak Pudu Kuala Lumpur 55100
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text:
|Road Name:
|Bells Lonnen
|Road Type:
Bells Lonnen is a street in the settlement of Prudhoe governed by Prudhoe Civil Parish council in the administration area of Northumberland Council located in the North East Euro Region of the UK.
Bells Lonnen is located 250.13 miles North from the centre of London, 9.28 miles West from the centre of Newcastle upon Tyne, 43.69 miles East from the centre of Carlisle and 74.13 miles North East from the centre of Lancaster.
Bells Lonnen is approximately 1.36 miles from the coastal tidal high water mark) and is 55 metres above sea level
Postcodes for Bells Lonnen
|The Central point of Bells Lonnen is approximately 55 Metres above sea level
Hotel information updated 09/10/2016
|The Ship Inn - wylam
|Star Rating:
|2 Stars
|Featuring free WiFi throughout the property, The Ship Inn offers accommodation in Wylam, 13 km from Newcastle upon Tyne. Guests can enjoy the on-site bar. Free private parking is available on site. The rooms come with a flat-screen TV.
|Main Road nn., NE41 8AQ, Wylam
|Number of Rooms:
|Lowest Price Room:
|Laburnum Guest House at Bistro Englaze - wylam
|Star Rating:
|3 Stars
|Offering an � la carte restaurant, Laburnum Guest House is located in Wylam, and is just 11 miles from Newcastle. It features a garden, free Wi-Fi and free parking.
|Main Road, NE418AJ, Wylam, Northumberland
|Number of Rooms:
|Lowest Price Room:
|Holly Tree - ovingham
|Set in Ovingham, this holiday home features free WiFi. The property features views of the city and is 16 km from Newcastle upon Tyne. The unit fitted with a kitchen with an oven and toaster. A TV is provided.
|, NE42 6AW, Ovingham near Prudhoe
|Number of Rooms:
|Lowest Price Room:
|Winnie Cottage - mickley
|Winnie Cottage is a holiday home located in Mickley in the Northumberland Region and is 17 km from Newcastle upon Tyne. The property is 27 km from Durham and features views of the city.
|, NE43 7LU, High Mickley nr. Stocksfield
|Number of Rooms:
|Close House - heddon-on-the-wall
|Star Rating:
|4 Stars
|Set in stunning Northumberland countryside and its own scenic grounds, this privately owned, elegant 18th-century mansion is only 20 minutes
|Heddon On The Wall, NE15 0HT, Newcastle
|Number of Rooms:
|Lowest Price Room:
|Highest Price Room:
Local Council Details
|Within the area of Northumberland
|Visit the Council's Website
|County Hall
|Send Mail
|Telephone Number: 0845 600 6400
|Within the electoral area of Not Found -
|Within the Westminster Parliamentary Constituency of Hexham
|The Member of Parliament is Opperman, Guy
|Within the area of Prudhoe Civil Parish Council
Water and Drainage Details
|Northumbrian Water
|Visit Northumbrian Water's Website
Recent House Sales in Bells Lonnen
|27 Bells Lonnen
|Sale Price: £216,000
|Sale Date: 30/12/2015
|5 Bells Lonnen
|Sale Price: £150,000
|Sale Date: 22/05/2015
|Source: Land Registry Price Paid Data accessed via API
Population Statistics
|ONS Area Code: E01027497
|Ons Area Name:Northumberland 038A
|Average Age : 36.85
|Population: 2688.00
|Male Population: 1322.00 (49.18%)
|Female Population: 1366.00 (50.82%)
|Number Claiming Benefits: 27 (1%)
|Source: Office of National Statistics 2011 Census Data
Neighbourhood Policing
|Police Force:
|Find a Local Neighbourhood Watch Scheme
|Visit Police Website
|Visit Police Twitter
|Visit Police Facebook Page
|Email Police
|Telephone: 101
|Policing Links:
|Northumbria Police
Recent Crime in the Area
|Source: data.police.uk accessed via API
Map of Crimes Committed Near Bells Lonnen
Random Street
Victoria Street
Location Details
Bells Lonnen
|OS Reference: 409991, 563466
OS Grid Reference: NZ100635
|Latitude and Longitude: 54.965643957281, -1.8439319864354
|Approximate distance to the Coast: 1.36 miles
Ordnance Survey Landranger Map Series for Bells Lonnen
|Map Number: 88
|Map Name: Tyneside
|North East
Nearest Railway Stations
|Prudhoe Rail Station is 1.24 Kilometers away (0.77 miles)
|Wylam Rail Station is 2.26 Kilometers away (1.4 miles)
|Stocksfield Rail Station is 5.02 Kilometers away (3.12 miles)
|Riding Mill Rail Station is 8.29 Kilometers away (5.15 miles)
Nearest Airports
|Newcastle International Airport is 11.78 Kilometers away
|Durham Tees Valley Airport is 57.14 Kilometers away
Nearest Ferries
|Newcastle International Ferry Terminal is 25.52 Kilometers away
|North Shields Ferry Terminal is 26.01 Kilometers away
|South Shields Ferry Terminal is 26.19 Kilometers away
|Tower Knowe Ferry Landing is 46.52 Kilometers away
Nearest Motorway or Major Trunk Road
|Bells Lonnen is approximately 1.71 miles from the A69
Nearest Motorway Junctions
|Junction: A1(M) J65/A194(M)/A1(T)/A1231/B1288 - 19.73 Km Away
|Junction: A1(M) J64/A195 - 20.41 Km Away
|Junction: A1(M) J63/A167/A183 - 21.17 Km Away
Health Clinics
|The Adderlane Surgery
|The Adderlane Surgery, Adderlane Road,west Wylam, Prudhoe, Northumberland, NE425HR
|Distance: 0.35 Kilometers
|Telephone: 01661 836386
|Redbrick House
|Redbrick House, Victoria Terrace, Prudhoe, Northumberland, NE42 5AE
|Distance: 0.59 Kilometers
|Telephone: 01661 830677
|Prudhoe Medical Group
|Prudhoe Medical Group, Kepwell Bank Top, Prudhoe, Northumberland, NE425PW
|Distance: 0.66 Kilometers
|Telephone: 0844 8151585
|Riversdale Surgery
|Riversdale Surgery, 51 Woodcroft Road, Wylam, Northumberland, NE418DH
|Distance: 1.78 Kilometers
|Telephone: 01661 852208
Nearest Libraries
Prudhoe Library
|Front Street, Prudhoe, NE425AA
|Distance: 0.35 Miles
|Visit Website
Wylam Library
|Falcon Terrace, Wylam, NE418EE
|Distance: 1.41 Miles
|Visit Website
Crawcrook Library
|Main Street, Gateshead, NE404NB
|Distance: 2.24 Miles
|Visit Website
Nearest Tourist Attractions
Landmark or Antiquity
|Attraction Name: Castle
|Distance: 0.49 (km)
|Attraction Name: Prudhoe Castle
|Distance: 0.89 (km)
Tourist Attraction
|Attraction Name: Visitor Centre
|Distance: 1.63 (km)
Country Park
|Attraction Name: Tyne Riverside Country Park
|Distance: 1.74 (km)
Nearest Schools
Adderlane First School
|Distance: 0.30 Kilometers
|Type: Primary
|Address: Broomhill Road, Prudhoe, Northumberland, NE42 5HX
|Telephone: (01661) 833996
Prudhoe West First School
|Distance: 0.85 Kilometers
|Type: Primary
|Address: West Road, Prudhoe, Northumberland, NE42 6HR
|Telephone: (01661) 832288
St Matthew's Catholic Primary School
|Distance: 0.98 Kilometers
|Type: Primary
|Address: Highfield Lane, Prudhoe, Northumberland, NE42 6EY
|Telephone: (01661) 835484
Highfield Middle School
|Distance: 0.98 Kilometers
|Type: Middle Deemed Secondary
|Address: Highfield Lane, Prudhoe, Northumberland, NE42 6EY
|Telephone: (01661) 833922
Broadband Speed (megabits per second)
|Speed: Greater than 2 Mbps
|Average Speed: 16.3
|Median Speed: 16.4
|Maximum Speed: >=30
|Next-generation access (NGA)?: Y
|Number of Connections: 31


text:
@dreamthievin: Give me a break, ouija board. I don't need to know who was killed in this house. Just tell me how the murderer got away with it.
@withanewname: "Welcome to D.A.D.D.D.S. Dads Against Dads Doing Dumb Shit. Repeat after me." [whole room] "AFTER ME" "Ok fellas, lets start here"
@Traceykemp8: No officer,YOU`RE going the wrong way.
@ch000ch: if i ever go missing please don't use that photo of me holding a sign that says "if i ever go missing don't look for me." thanks
@myonlymizztake: These drawstring pajama pants practically fall down when I don't tie them, so I guess another piece of birthday cake is in order.
@Book_Krazy: [Gym] Hello ladies, and welcome to Body By Jake! Me: "Jake?" *i discreetly shove the cake I brought into my bag & back out of the room*


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Hustlers Brass Band
Short days got you singing the blues? Are you hungry for some free red beans and rice and funk-drenched brass-band jams? Got five bucks? Then get on down to the Big Top every Tuesday through the end of the year for Mardi Gras on Main, the Hustlers Brass Band's very first official Houston residency. Comprised of a half-dozen or so of New Orleans's top players from that city's historic and still-thriving brass band scene — many of whom now live part-time here in Houston — the Hustlers specialize in the Big Easy-fication of old-school funk and soul songs. On their debut CD Second Line Soul, the band gumbos up everything from "Cisco Kid," "Brick House" and Bill Withers's "Use Me" to the themes from Sanford and Son and The Jeffersons. Not that they shun the traditional New Orleans brass band repertoire: Hymns like "Just A Closer Walk with Thee" and street parade jams like "The Second Line" and "Mardi Gras in New Orleans" get equal time, as does their irreverent take on the ancient "St. James Infirmary." Powerhouse snare drummer Lumar Leblanc — a big man with hands as fast as hummingbird wings — leads one of the most exciting rhythm sections you'll ever see, while the layered horns (two trumpets, trombone, sax) shimmer with Earth, Wind & Fire sheen.
Get the Music Newsletter
Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
Related Location
3714 Main
Houston, TX 77002
In Case You Missed It
Upcoming Events
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TicketsSun., Oct. 23, 7:00pm
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TicketsFri., Oct. 28, 7:30pmpowered by goldstar
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5083 Verbena St Denver, CO Apartments
Denver, CO
Dogs Ok
Cats Ok
4 Bedroom
3 Bathroom
3 Baths
2,694 ft2 2694 ft2
Listing Description
Newer single family home in stapleton near northfield! - this 4 bed, 4 bath home was built in 2014 is located in the conservatory green neighborhood of stapleton. It is located blocks from northfield and two blocks from the maverick pool and across the street from high tech elementary school. The house is situated on a courtyard. It is a great place for the kids to play since you are tucked away from the street. The house has three bedrooms on the 2nd floor and two full bathrooms. The master bedroom has a large balcony that faces the courtyard. The main floor has a the family room, dining, kitchen and half bath. The modern kitchen has 42" upper cabinets and stainless steel appliances with a gas stove. The house has a south facing side yard that is fenced in. There is also a two car attached garage. The basement has a family room, bedroom and a full bath. The house is available . Pets negotiable with an additional security deposit.
Credit and background check required.
Credit and background check required.


text:
There are millions of Internet-Servers daily hacked from the same hand full of Hackers.
Every Webmaster has the same problems with Hackers, Intruders, Attackers and Spammers, but nobody is fighting against these Terrorists.
Should that then go on forever?
No, we are fighting against Hackers, Intruders, Attackers, Spammers, Cyber Terrorists and 126.96.36.199!
Fri, 28 Oct 2016 20:36:27 GMT - Actual more as 21.000.000 Hackers in our Database. (The newest 100 are displayed on the Globe and Map)
Details for IP 188.8.131.52
WebServer Output: http://188.8.131.52
IP Geo Information: 220.127.116.11
☎ Whois 188.8.131.52
HTML Markup Validation 18.104.22.168
The Web Site Header: 22.214.171.124
Black Listed: 126.96.36.199
Ping to 188.8.131.52
Open Ports on 184.108.40.206
Geo-Location Information 126.96.36.199
Tor lookup for IP 126.96.36.199
Reputation of 184.108.40.206
Trace a Route to 22.214.171.124
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Bad Neighbor IPs of 184.108.40.206
256 bad neighbor IPs are known!


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text:
Explore these ideas and much more!
Looking for Father's Day gift ideas? Look no further. Make him steak rub spices to bring out the 'Grill Master' in him! #fathersdaygiftideas #recipe
Outback Steak Rub Spice Mixture ~ 4 teaspoons salt 4 teaspoons paprika 2 teaspoons ground black pepper 1 teaspoon onion powder 1 teaspoon garlic powder 1 teaspoon ground red pepper 1/2 teaspoon coriander 1/2 teaspoon turmeric Directions: 1Mix, sprinkle lightly on your favorite cut of beef, then cook as desired!
5 New Ways to Meet Mommy Friends from our Pearista, @See Vanessa Craft!
Ghastly Halloween food ideas to get you inspired this year! #peartreegreetings #halloween
You can put a cute family photo on this notepad and still write on it. #giftideas #notepads
A wood-grain background and colorful butterflies decorate these personalized, custom notepads which will put friends and family in a happy mood every time they use them.


text:
sterilize in Birth topic
From Longman Dictionary of Contemporary Englishsterilizester‧il‧ize (also sterilise British English) /ˈsterəlaɪz/ verb [transitive] 1 CLEANto make something completely clean by killing any bacteria in it Sterilize the bottles with boiling water. sterilized milk sterilizing solution2 MBBABY/HAVE A BABYif a person or animal is sterilized, they have an operation to stop them producing babies —sterilizer noun [countable] an electric sterilizer —sterilization /ˌsterəlaɪˈzeɪʃən $ -lə-/ noun [countable, uncountable]→ See Verb table
Examples from the Corpussterilize• Has the needle been sterilized?• The National Fertility Survey found that out of the total of women using contraception, 52.5% had been sterilized.• Lakes and ponds were tapped, water from the Lys sterilized and stored in barges, and cisterns built to trap rainwater.• The largest mineral resource deliberately sterilized by the process was the Windy Craggy copper property in the remote northwestern corner of B.C.• There is no need to launder bedding or sterilize clothing.• After all, it is illegal to grow hemp in the United States, though sterilized hempseeds may be imported legally.• Place lemons in a sterilized jar and sprinkle with remaining 21 / 2 tablespoons salt.• Ordinary chlorine bleach kills the virus on contact and can be used to sterilize needles between uses.• Babies' bottles can be sterilized simply by boiling them in water.• Sterilize the needle in boiling water.
Explore Birth Topic
- spay
- midwifery
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- procreate
- diaphragm
- infertile
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- oviduct
- surrogate mother
- fertility drug
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- swaddling clothes
- pregnancy
- sterilize
- zygote
- bear
- ovulate
- incubator
- fetus
- miscarry
- reproduction
- morning-after pill
- childbirth


text:
All hotels in Green Bay, Wisconsin, United States of America
1 room, 2 adults
2870 Ramada Way, Green Bay, WI, 54304, United States of America, 800-491-6126
Motel 6 Green Bay - Lambeau, Green Bay
Lowest price$40
available on 10/31/16
Price Guarantee
No-frills hotel in Ashwaubenon
- Free WiFi and free parking
Main amenities
- 102 guestrooms
- 24-hour front desk
- Coffee/tea in a common area
- Air conditioning
- Self-serve laundry
- Meeting room
For families
- Private bathroom
- Television
- Laundry facilities
- Cable TV service
- Free self parking
What's around
- Bay Park Square (1.1 mi / 1.8 km)
- National Railroad Museum (2.2 mi / 3.6 km)
- Shopko Hall (2.3 mi / 3.8 km)
- Lambeau Field (2.4 mi / 3.8 km)
- Resch Center (2.4 mi / 3.8 km)
- Green Bay, WI (GRB-Austin Straubel Intl.) 7-min drive; 4.2 miles/6.7 km
- Appleton, WI (ATW-Outagamie County Regional) 33-min drive; 30 miles/48.3 km
- Free self parking
- Extended parking
- Free RV, bus, and truck parking
See all 251 Hotels.com reviews
More comfort would be nice
Room needs to be redecorated
Could use a good cleaning
Amenities are not the best
TripAdvisor Traveller Rating: 3
From 249 reviews
Motel 6 Green Bay - Lambeau, Green Bay
Hotel Info: 866-539-8117from $40
- Double Room, 2 Double Beds, Accessible
- Standard Room, 1 King Bed
- Standard Room, 1 Double Bed, Non Smoking
- Double Room, Accessible
- Standard Room, 1 Queen Bed
- Standard Room, 1 King Bed, Non Smoking
- Standard Room, 1 Double Bed, Accessible, Non Smoking
- Standard Room, 2 Double Beds, Non Smoking
- Standard Room, 1 Queen Bed, Non Smoking
- Double Room, 2 Double Beds
- Standard Room, 1 King Bed
More great choices
At a glance
Key facts
Hotel size
- This hotel has 102 rooms
- This hotel is arranged over 2 floors
- Check-in time starts at 3 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets stay free
- 2 per room
- Free WiFi and wired Internet access in rooms
- Free self parking
- Extended parking
Nearby Two Star Green Bay hotels
In the hotel
Food and drink
- Coffee/tea in a common area
Working away
- One meeting room
- 24-hour front desk
- Laundry facilities
- Number of buildings/towers - 1
- Designated smoking areas
- Accessible bathroom
- In-room accessibility
In the room
Home comforts
- Air conditioning
Freshen up
- Private bathroom
- Shower/tub combination
Be entertained
- Cable TV channels
Stay connected
- Free WiFi
- Free local calls
Top Green Bay hotels
Recently reviewed hotels in Green Bay
- AmericInn Lodge & Suites AppletonFrom
"Quick stay for a Packer game. Nice clean motel."Oct 18, 2016
- Microtel Inn & Suites by Wyndham AppletonFrom
"The owner is always there and keeps up with all of the needs of the breakfast. They have lots of hot items (eggs, sausage, waffles) and breads, yogurt, fruit. It's a decent…"Oct 18, 2016
- Radisson Paper Valley HotelFrom
"Nice hotel but it's dated. Needs to be refurbished. Went to Lombardis Steakhouse inside hotel and it was delicious."Oct 18, 2016
- Wingate by Wyndham Green Bay/AirportFrom
"The location was great for us going to a concert at the Resch Center and took an uber. Hotel is right across the street from the Oneida casino and next to the airport if needed.…"Oct 18, 2016
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Also popular with travelers from the USA
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text:
Is The Logistics Institute incorrect or missing key business information? Update your Hotfrog listing today.
Contact details
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Hotfrog Singapore provides information regarding The Logistics Institute in Singapore. The Logistics Institute is located at National University of 21 Heng Mui Keng Terrace 04-01, Singapore 119613 and provides Engineering services. Contact them on (65) 6516 4284 or by visiting them on their website http://www.eng.nus.edu.sg/tliap.
Is The Logistics Institute in National University of 21 Heng Mui Keng Terrace 04-01, Singapore 119613 your business? Claim your listing and attract more leads by adding more content, photos and other business details.
We have more Engineering services in Singapore available on Hotfrog Singapore. You can update your search for Engineering by location, keyword or service options.
264 Upper Bukit Timah Rd #03-06 Singapore 588208
51 Cuppage Road #07-22 Singapore 229469 Singapore 229469
5001 Beach Road 06-26 Golden Mile Complex Singapore 199588
10 Kaki Bukit Road 01-25 Singapore 416175
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text:
Tickets are still available for a popular event hosted by the junior class of Iowa Mennonite School.
Keywords: Iowa Mennonite School, Larry Swartzendruber
A sequel to a gospel production is coming to the Iowa Mennonite School.
Iowa Mennonite School will be presenting their fall play this weekend called; All I Really Need to Know I learned in Kindergarten.
Keywords: All I Really need to Know I Learned in Kindergarten, Iowa Mennonite School, Larry Swartzendruber
For the first time in history, a self-driving vehicle shipped commercial cargo from one city to another. Is truck driving a dying occupation?
View Results
call: (319) 653-2113


text:
Mong La, Mayanmar, is once again opening casino doors to Chinese citizens, but this time they're virtual doors rather than real ones as Internet-based casino businesses are being set up in the city.
For years China has been trying to curtail the casino business in Mong La, Myanmar. In January 2005, the casino and hotels in the city were closed down after Beijing banned its officials and citizens from traveling to Mong La. It was an effort to keep citizens from gambling as well as an effort to prevent money from being laundered through the gambling establishments.
Now, Lin Mingxian, more widely known as Sai Leun and who is thought to have funded the initial gambling industry growth in the city in the 1990s, is expanding his enterprise into online gaming. Seven new Internet-enabled gambling operations that are specifically designed and outfitted for online China-based gamers were opened in April of this year.
The new casinos are set up so gamblers in Beijing, Kunming, or Shanghai can watch the gaming tables via a live video feed over the Internet. They have to transfer funds to the casino operators' China-based bank accounts and then they can log in on the Web site to watch the games and place their bets over the phone through agents on location at the casinos.
When done, the gambler can either have his winnings wired to his account or have the agent get the cash physically from the casino.
Fourteen more similar gambling venues under construction southwest of Mong La.


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Sugar Baby Watermelon
If you are thinking of growing watermelon this year and haven't yet decided what variety to attempt, you might want to think about growing sugar baby watermelons. What are sugar baby watermelons and how do you grow them? This article will help.
How to grow Sugar Baby Watermelons from seed, determine when the watermelons are ripe, and harvest the watermelons.
Blueberry Banana Oat Muffins
Meet the rainbow whole fruit popsicle. No chemicals, artificial colours, no added sugar of any kind, no other ingredients other than whole fruit!
Banana and Date Flapjacks free from gluten, dairy, eggs, soya, nuts and refined sugar.
Apple wedges lightly fried in coconut oil and cinnamon. A great snack for blw as they are soft enough for a baby to gum and easy for them to grip.
Frozen Watermelon Push Pops recipe tutorial from Eats Amazing UK - quick easy healthy snack for summer - fun food for kids
Salted caramel chocolate torte. Indulge guests at your next party with this impressive dessert. A touch of salt really sets off the caramel and dark chocolate
supergolden bakes
Rainbow whole fruit popsicles. blueberry, kiwi, strawberry mango watermelon pineapple