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Orange County Mormon Choral Organization (OCMCO) Opens its Second Season & Auditions Are Underway
The Orange County Mormon Choral Organization (OCMCO) announces the opening of its second season with auditions underway until September 18, 2008 for ages 4 through adult. Visit www.OCMCO.org for info regarding sign-ups, registration and auditions.
OCMCO has seven different performing ensembles: the Sunbeam Chorus (ages 4-6); the Children's Chorus (ages 6-10); the Youth Chorus (ages 10-14); the Concert Choir (ages 14-18); the Orange County Mormon Choir and Women's Chorus (both for adult participants);
Auditions for the orchestra, high school choir (14-18), and the adult choir (18 and above) for OCMCO's 2008-2009 season, which will continue until September 18th, are scheduled by appointment. For youth ages 4 to 13, interest and registration forms are found online. Please visit www.OCMCO.org for all information regarding sign-ups, registration and auditions.
The Orange County Mormon Choral Organization is an independent non-profit organization founded in order to teach and encourage excellence in quality sacred, choral and classical music. Its primary purpose is to provide a unique and unsurpassed level of music education to members of The Church of Jesus Christ of Latter-day Saints in Orange County. It also seeks to offer this tremendous opportunity to members of all faiths throughout the community. In doing so, OCMCO provides an invaluable learning environment whereby children, youth, and adults can associate with and share talents with those who maintain upstanding values.
After its success last year, directors and brothers Brett and Brandon Stewart have been asked to start a similar organization in East Valley, Arizona. The East Valley Mormon Choral Organization, with already hundreds of anticipating interested musicians, will debut in the fall of 2009. Visit www.EVMCO.org for more information.
"Our public schools offer little, if any, musical training," said OCMCO Co-founder Brett Stewart. "And, with the constant intrusion of popular music, our appreciation for sacred, traditional choral and classically-
OCMCO's opening concert for this season, All the Bells on Earth Shall Ring, will take place on December 3, 2008, at 7:30 p.m. at Segerstrom Concert Hall. The Christmas concert will feature John Williams' Three Holiday Songs (Somewhere in My Memory, Star of Bethlehem and Merry Christmas, Merry Christmas) from the movie Home Alone for choirs and orchestra; Leroy Anderson's "Sleigh Ride" for orchestra; and new inspiring arrangements for choir, orchestra and bells. Pre-concert performances begin at 7:00 p.m. on the newly inaugurated William J. Gillespie Concert Organ. Tickets for All the Bells on Earth Shall Ring will go on sale October 1st through the Orange County Performing Artscenter's Box Office by calling (714) 556-2787 or visiting www.ocpac.org.
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Well Christmas break is officially over and as all good things must come to an end, so must this I suppose. It was a good one for me and my family. I'm thankful for the very generous six days I got to spend with some of my favorite people. I have to say, I did manage to make the most of my six days and have a new appreciation of family time.
This year my family decided to start a new tradition, which I got to be a part of. Instead of buying each other gifts we decided to put our money together and give a family in need a very special Christmas.
We delivered presents, a Christmas tree, and Christmas dinner to a needy family, a single mom with six children. It felt so good to see all the little kids faces light up when we came in. Their mother said God had answered her prayers. It had been a difficult year for their family with a lot of recent tragedies and this was a "miracle." I think we all felt the Christmas spirit that day. It was definitely an eye-opening experience for me and especially for my younger sisters Briley and Emma.
I was able to enjoy a few days of pure rest and relaxation while home which is always a bonus. Sleeping in, waking up to the smell of fresh brewed coffee, bacon frying, and my Mom's homemade sourdough bread baking are just some of my favorite things about being home for the holidays. I am not going to lie, I was a little pampered and it felt good.
Christmas is my favorite holiday and even though we started a new tradition this year, I also enjoyed some old ones too. Every year we wear our onesies (feet pajamas) to bed Christmas Eve and at approximately 7:00 a.m. I am awakened by my little sisters jumping up and down on my bed to go see what Santa brought us! This year was no different. I think I still get just as excited as I did when I was little. Santa came through again with some pretty awesome gifts.
One of my favorite parts about presents is the gifts I always get from the little ones. You really never know what you're going to get and it's usually very creative. This year I have to say Emma won 'most original' gift giver. She gave me two pictures she found of her and I together and one of Briley's old necklaces. Haha. But the present she gave my mom was the best of all, a true 'Emma creation" -- an ornament with three cotton balls strategically glued to it. Not sure what the inspiration for that was exactly, but hey, it's the thought that counts, right?
I also managed to find time to spend with some of my high school friends too. It was fun catching up with everyone. Even though we don't get to see each other much anymore now, it seems like we can just catch up right where we left off.
I was able to catch a girl's high school basketball game while I was home and talked to some of my old teammates and coaches. It felt a little strange being a spectator though. It's definitely a different arena than college ball that's for sure!
I had a wonderful time over break with friends and family. I got to ride four wheelers, ate too much, slept in late and had laundry service too. Overall, I'd say it was as perfect a Christmas break as I could ask for. I'm very blessed and so thankful for my family & friends.
Now it's back to the grind. I'm glad I worked out over the break because we've had some tough practices preparing for our upcoming games! We play Old Dominion Thursday and then head straight into conference games!
Go Duke!
Rebecca Greenwell
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Sunshine Coast Festival of the Written Arts 34th Anniversary
August 11-14, 2016 — Sechelt, BC
Join Canada's longest running summer gathering of Canadian writers and readers, featuring established literary stars and exciting, new voices… with opportunities for writers and readers to mingle amidst Rockwood's heritage gardens.
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2016 FOWA Raffle Prize Winners:
1st Prize — 2017 Festival Pass: Rehana Nanjijuma
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Congratulations winners!
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Home Concert Tickets Alternative and Indie Lambchop
Lambchop Tickets
Often considered one of the best American bands of the nineties, Lambchop have a sound deeply rooted in country music. Creative force and frontman Kurt Wagner's songwriting has been compared to that of soul legends Barry White and Marvin Gaye, creating an overall sound which is warm and sentimental. The Nashville band have a reputation for fantastic live performances, so Lambchop tickets are sure to sell quickly.
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Closed captioning is an assistive technology that allows persons with hearing disabilities to access television programming. Closed captioning displays the audio portion of programming as text superimposed over the video. For a television receiver to display closed captions, it must use a set-top box decoder or contain integrated decoder circuitry.
All English language programming, defined as analog programming first published or exhibited on or after January 1, 1998, and digital programming first aired on or after July 1, 2002, were closed captioned as of January 1, 2006- with some exceptions.
The Federal Communications Commission (FCC) is concerned that consumers may experience difficulty in receiving and/or viewing closed captioning on some digital television (DTV) programming, including high definition television (HDTV), provided by a subscription television provider, such as a cable company or a satellite television provider. These difficulties generally could arise from two causes: 1) the consumer's set-top box and/or DTV are not properly set to allow closed captions to be displayed; or 2) there are technical problems with the subscription television provider's system that prevent closed captions from being received and decoded by the set-top box and/or DTV.
What You Can Do
If you have difficulties viewing closed captions on DTV programming, including HDTV, received from your subscription television provider, you should:
- consult any consumer information i.e., manuals or guides on closed captions for DTV programming provided by your subscription television provider;
- ensure that the captioning function on your set-top box, if applicable, is turned on;
- ensure that the captioning function on your DTV is turned on.
If you are still unable to view closed captions on DTV programming, you should contact your subscription television provider for assistance.
If your provider is unable to help, you can file a complaint with the FCC alleging a violation of the Television Decoder Circuitry Act and the FCC's implemented rules. There is no charge for filing a complaint.
If your complaint concerns the inability of your consumer equipment (i.e., your television or cable box) to deliver captions, you may complain directly to the FCC. If your complaint concerns the lack of captioning on a specific program or channel (i.e., you receive captions on some channels, but not others), you may file a complaint with either the FCC or your video programming distributor (meaning your subscription television service provider or the television broadcaster).
Filing a complaint
You have multiple options for filing a complaint with the FCC:
- File a complaint online
- By phone: 1-888-CALL-FCC (1-888-225-5322); TTY: 1-888-TELL-FCC (1-888-835-5322); ASL: 1-844-432-2275
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Now the FBI investigates 14 Barclays staff at the heart of the rate-rigging scandal
- Traders under scrutiny are based mainly in London and New York
- It follows the £290m fine given to Barclays for fixing Libor lending rate
The FBI is investigating 14 Barclays traders at the heart of the Libor-fixing scandal, it emerged yesterday.
Although much of the immediate political fallout over Barclays has occurred in the UK, the US could become the main legal arena for the scandal, with financial and custodial punishments dwarfing those imposed elsewhere.
The City of Baltimore has already launched a class action suit and the brokerage firm Charles Schwab has brought a lawsuit in California.
Probe: Fourteen Barclays traders at the heart of the Libor-fixing scandal are being investigated by the FBI (File photograph)
The Schwab lawsuit, filed against several banks, including Barclays, HSBC, Lloyds and RBS, indicates the scale of the scandal could be far bigger than first thought.
The FBI investigation was announced by Assistant Attorney General Lanny Breuer. The 14 traders under scrutiny are believed to have been based mostly in London and New York.
As part of a non-prosecution agreement last week, Barclays paid a record £59.5million to Britain's Financial Services Authority, while American regulators and prosecutors took about £230million.
The deal covers Barclays but not its current and former employees.
Barclays has agreed to assist US investigators, essentially becoming a co-operating witness against some of its own people and rival banks.
Mr Breuer noted last week that Barclays had 'substantially assisted the Criminal Division in our ongoing investigation of individuals and other financial institutions in this matter'.
Scrutiny: The FBI investigation was announced by Assistant Attorney General Lanny Breuer
President Barack Obama formed a Financial Fraud Enforcement taskforce in 2009 which, the US Department of Justice highlighted last week, was designed 'to wage an aggressive, co-ordinated and proactive effort to investigate and prosecute financial crimes'.
The result could be extraditions of bankers to face US courts – even if the alleged criminal acts did not take place on American soil.
A 23-page statement of facts regarding Barclays was drawn up by the Justice Department and posted on its website and that of the FBI.
The document paints a picture of a network of traders conspiring on both sides of the Atlantic to manipulate both the Libor and Euribor rates.
The document, in a statement of facts agreed to by Barclays, said 'interbank communications' included 'ones in which certain Barclays swaps traders communicated with former Barclays swaps traders who had left Barclays and joined other financial institutions'.
High stakes: A lawsuit has been filed in the US against several banks, including Barclays, HSBC, Lloyds and RBS
According to the Schwab lawsuit, each bank 'dramatically increased its collusive suppression of Libor'. It claims that 'under-reporting of Libor had a $45billion (£28billion) effect on the market' – a shortfall that the banks avoided paying to investors buying their financial products.
Manipulating Libor would have had a significant effect on pension and investment funds that buy complex financial products, known as derivatives, linked to interest rates.
At least 16 of the world's biggest banks, including UBS, Deutsche Bank, Citigroup, HSBC, RBS and Lloyds, are likely to be looked at by the FBI or other US federal agencies. As well as Britain and the US, investigations are taking place in other European countries, Japan, Canada and Singapore.
Inquiries are centred around which banks participated in the alleged collusion and whether any criminal actions were authorised or condoned by senior figures. Canada's Competition Bureau filed an affidavit against banks including HSBC and RBS, demanding emails and other documents.
According to the affidavit, one bank became a whistleblower and agreed to assist the authorities.
A trader at the whistleblower bank is alleged to have communicated with traders at HSBC, Deutsche Bank, RBS, JP Morgan and Citibank.
Last week, Harvey Pitt, former chairman of the US Securities and Exchange Commission, said Barclays' actions over Libor were likely to be only 'the proverbial tip of the iceberg'.
More to come: Harvey Pitt said Barclays' actions over Libor were likely to be only 'the proverbial tip of the iceberg'
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Key Outcome of the Pacific World Heritage Workshop
The 4th Pacific World Heritage Workshop was held in Apia from 5 to 9 September 2011. Hosted by the Government of Samoa, it brought together some 70 participants and experts from and outside the Pacific region.
Acting Prime Minister and Minister of Finance, Faumuina Tiatia Liuga opened the Workshop. In his keynote speech illustrating the history of the World Heritage Programme and the Pacific, he said "The land, monuments, culture, traditions and way of life that our ancestors have left us are the living proof and testimony to our history, and to the factors that have shaped the uniqueness of our identity".
Under the chair of Mr Taule'ale'ausumai Laavasa Malua, CEO of the Ministry of Natural Resources and Environment, the Workshop provided an opportunity to share issues and challenges on the World Heritage programme across the Pacific, which included, among others World Heritage periodic reporting, integrated application of international conventions, Pacific Heritage Hub project, Pacific representation at the World Heritage Committee.
The Workshop noted the growing interest in the ways in which World Heritage activities intersect with other natural and cultural conventions. In the culture sector, the participants reaffirmed the interface between tangible and intangible cultural heritage which is very clearly expressed in the Pacific where cultural heritage includes the strong oral traditions and the story of the community. As such, any discussion on cultural heritage in the Paciic involves a broad discussion on ICH safeguarding and community empowerment.
Participants emphasized the importance of cultural and natural heritage in sustaining identity and the well-being of the peoples of the Pacific. In addition, however, they noted that the heritage of the Pacific is valuable as major assets for the sustainable future of the Pacific islands states and territories. Participants argued that maximizing this benefit will require the building of new partnerships - including with the private sector and the tourism industry, and support for cultural industries and heritage-based enterprises at the local level.
Acknowledging considerable progress of the Pacific World Heritage Action Plan (2010-2015) communicated through the country reports presented at the Workshop, the Workshop also identified new regional actions to achieve remaining goals by strengthening networking and capacity building activities. The Workshop also expressed support for Palau's indication of its candidature for the World Heritage Committee.
The outcome of the Workshop including the results of the World Heritage periodic reporting exercise will be finalized as updtated Pacific World Heritage Action Plan and reported at the World Heritage Committee meeting planned for July 2012.
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Leave a Review
Excellent, light, moist, flavorful cake. I baked for 30 minutes and thought it could have come out of the oven a tad sooner. Cherry sauce was delicious. The only problem with this recipe is that sour cherry season is just too short!
This was excellent and easy. I used gluten-free flour so my husband could eat it too and it turned out perfect. We don't get sour cherries in Berkeley so I used sweet and 1/2 the amount of sugar (and I should have used 1/2 the amount of water), also added some lemon and zest per another review. And added brandy after the cherries had cooled a bit and a pinch of salt - delicious!
I just made this sour cherry sauce without the torte to go with the Black Forest Cake I made except I halved the recipe as I was using leftover cherries. I also added an oz of dark chocolate and I have to say - it's pretty tastey!
Delicious, and quite easy! -- a friend gifted some sour cherries, and having no idea what to do with them, I tried this recipe. Torte itself is a wonderful buttery-almondy cake, and the sour cherry sauce is a perfect accompaniment. (Only comment, I'm not sure why the recipe calls for "blanched whole almonds"; as you food process them anyway. Next time I will just use a cup of the "sliced almonds" that you use anyway to garnish the torte.)
This is a wonderful, and wonderfully easy recipe for a delicious, moist cake. If you like marzipan you will love this cake. It is true that it should not be made more than one day in advance or the toasted almonds on top may become too chewy, but you could just avoid using them since this cake seems to maintain its richness and becomes even better and still very moist after a few days! I inverted the cake on a wire rack to try to prevent it from sinking and that seemed to work very well.
Love this cake, have made it many times before, but this time I had a problem. For some reason the cake rose up the sides and was flat and uncooked in the middle. It looked like a pei crust! I am bogled as to why this happened. The only thing I changed was I used unbromated flour. Really, I have made this before and it turned out beautifully. Please, any input would be welcome.
Outrageously good cake! And I'm not usually a big cake fan. Took this to a Christmas Eve dinner and it was a hit. I doubled the recipe to make two layers. Instead of the sour cherry topping I used a really good brand of cherry preserves. I frosted it with Buttercream with a little almond extract and pressed toasted, sliced almonds on the sides and an arrangement of cherries and other fruit on top - glazed with melted apricot jam for shine.
This is one of my favorite dinner party desserts. The cake is light, moist, not too sweet and has wonderful flavor. It is also exceptionally easy to make. Instead of the sour cherry sauce, I make a sauce with frozen dark sweet cherries. I briefly cook the cherries with a bit of sugar and touch brandy. Serve with the sauce and a dollop of whipped cream. So easy, and so goo. Everyone I've served this to loves it.
This is an excellent cake! I have made many times -- initially w/ sour cherries when they're in season (which is about 3 weeks tops!) Now that it's winter, I've been serving cake w/ dried fruit -- cherries, raisins & apricots -- poached in simple syrup & vanilla bean, adding orange zest. It's light w/o the egg yolks, and not overly sweet. Reliable and always a hit!
This is a delicious european style cake that slices cleanly and transports well. I used almond flour for the 4 oz of almonds and then dusted the finished cake with powdered sugar for a more attractive presentation. I had some good canned sour cherries and used that for the sauce and added a dash of kirsch. The cake makes a great base for all kinds of fruit compotes. This recipe yields 10 servings.


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text: As a kid, our house always smelled like delicious food. Once breakfast was done, my grandmother would start sautéing garlic or julienning carrots for the next meal. It was an ongoing cycle, and one that we all enjoyed. Looking back, I consider myself lucky to have had the luxury of home-cooked meals all day, every day. Read More »


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What the hell is BCBG doing in a game full of drugs, blood, and funky music? For those not familiar with the brand, it is a clothes, fashion accesories and little-flashy-really-small-really-expensive things by a designer called Max Azria, but I'm not here to play as Joan Rivers or Fashion Police. My concerns rest in the next idea:
Advertising is a big part of our lives. We see TV commercials, spots, billboards, propaganda, pop-ups, spam, The freaking Hulk banner in 1up we all hated, and so on. It is such a big part of our lives we don't even pay attention to it. We ignore it in such a desperate effort of being alone for 5 minutes between what I'm doing and what I'm going to do.
We've all played or at least seen a sports game where the letters COCA-COLA appear, or NIKE or BLA BLA. Call it realistic, but it is in a way annoying. So I'm scared. I'm scared of this things invading my personal gaming space.
It's called "In Game Advertising", and it is as scary as it sounds. And yes, there are companies that do this, companies that have major developers as partners. Take a look around www.massiveincorporated.com for instance.
Imagine your next Halo 3 online match:
As you turn on your brand new XBOX 360 A loading screen reads: "PLEASE TAKE A MINUTE TO HEAR A WORD FROM OUR SPONSORS" The new COCA-COLA ad appears and OH! My God!! It's the one with the cute little bears. After this one, you get to choose your playing map:
** The ADIDAS battle arena
** The Ronald McDonald stadium
** The Bill Gates colloseum
The Chief is wearing sponsors!!!!!! He's got G&E, Sprint.............
Ok ok, so maybe I'm being paranoic, but I'm concerned as a gamer. This things are capable of turning videogame advertising as a part of our everyday life, SO everyday, we start ignoring it.
If Video Killed The Radio Star......


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The next time you see free lunches being handed out by Weld Food Bank volunteers, or little league soccer coaches shaking hands after a good match, or volunteers helping area adults in the Special Olympics, there's a good chance you're watching oil company employees.
That's because the oil companies that are currently working throughout Weld County realize they have a corporate duty to give back to the communities that they work in.
It's not a new idea either.
"I think we've always done it. It's just that we haven't made it public," said Greg McIntosh, completions manager for Anadarko Petroleum Corporation. Anadarko, based in Houston, Texas, is one of 31 oil companies currently drilling in Weld County.
McIntosh, who has served on the Weld Food Bank's board of directors for the past six years, said there are several good reasons why oil companies like his are trying to be good stewards and partners in the communities where they work.
"We live here. It's our community, too," McIntosh said. "We're not just passing through. Most (Anadarko employees) here are lifelong Weld County residents. And, this is just the right thing to do. It's the way we were raised."
McIntosh said the Weld Food Bank is just one of many organizations that his company helps out. He listed the Greeley Transitional House, the Greeley Assistance League, Special Olympics, the Weld County Fair, 4-H, and Weld County United Way. He also said Anadarko employees volunteer as area coaches and are involved in Junior Achievement "just to name a handful."
That kind of help is greatly appreciated, too.
"The oil and gas companies have been very, very helpful," said Weld Food Bank Interim Executive Director Bob O'Connor. "Anadarko volunteers, for instance, make emergency food boxes. They hold a competition to see how many they can make. They hold the current record. Other (oil companies) come in and try to break it. But, it still stands."
Kevin Mullin, the Weld Food Bank's Director of Development, said Anadarko Petroleum Corporation, Noble Energy Inc., and Encana Corporation top a list of 15-20 oil companies that help the food bank on a regular basis.
"These companies understand their corporate responsibility," Mullin said. "If you're doing business in a community, you take responsibility to help that community as much as possible."
Mullin pointed out that Anadarko donated about $50,000 this year to the food bank. He said Noble Energy gave about $20,000. And, Encana holds a chili cook-off each fall with proceeds going to the food bank.
Mullin said that since the food bank can leverage a $1 donation into about $10 worth of food, those kind of monetary donations feed a lot of people.
"It really makes a big impact," Mullin said. "It's huge. We really appreciate their kindness."
Wendy Wiedenbeck, the community relations manager for Encana Corporation, said giving back to communities is a priority for her company.
"It's certainly a big part of Encana," Wiedenbeck said. "It's who we are. Our employees value giving back to the community."
Wiedenbeck said Encana, as a corporation, sets aside a certain percentage of its profits to help local programs grow.
"We look at programs that are self-sustained but with our contribution, we can make it stronger or help it to expand its services," Wiedenbeck said.
Wiedenbeck said that Encana employees play a key role in these decisions.
"Their input is very valuable," she said. "I receive great applications (for assistance) but it's important to get boots-on-the-ground information from our employees."
Besides the chili cook-off and charitable grant donations, Encana also passes out a number of $10,000 scholarships to high school seniors throughout Weld County.
"In many cases, one of our employees knows the winner and makes the presentation," Wiedenbeck said. "That means a lot."
Wiedenbeck added that Encana has earmarked about $4 million for eligible non-profits this year in the Denver-Julesburg oil and gas basin. She said most of that would go to entities in Weld County.
"We're very proud of that," Wiedenbeck said.
While Weld County benefits financially from the royalties and taxes provided by the oil and gas companies and from the job creation, county officials say they are most pleased with the way that employees of these companies get involved on a local level.
"I believe the most important contribution is they encourage their people to be involved in Weld County and in the municipalities they live in," said Sean Conway, the chairman of the Weld County Commissioners. "They're a benefit to all our citizens."


text:
Justin Timberlake releases new single with Jay-Z
After focusing primarily on acting for the past few years, Justin Timberlake finally released his first single since 2006's "FutureSex/LoveSounds" album late Sunday night. "Suit & Tie," featuring Jay-Z, will appear on his next album "The 20/20 Experience," out this year. Photo courtesy of the Associated Press. »Read Full Blog Post(2)
At Hinterland, a tasting menu for diners who love vegetables
Hinterland, 222 E. Erie St., has begun serving a four-course, $40 vegetarian tasting menu.
It's to take advantage of summer's bounty, and will continue as long as the restaurant's farmers who supply the kitchen are harvesting, said chef Dan Van Rite. »Read Full Blog Post
Music, singing shine in 'Phantom of the Opera' at Marcus Center
In any production of "The Phantom of the Opera," things first really kick into gear when Christine descends into the Phantom's lair, lured by that intoxicating voice that's already firmly lodged inside her mind.
It's still more thrilling — in the revamped and lavishly designed touring "Phantom" now at the Marcus Center — to watch Christine take that precarious, vertigo-inducing plunge along a series of seemingly free-floating stairs, which emerge one by one from a revolving, two-story turret. »Read Full Article
RiverMill Foods opens in its new location, in Elm Grove
With its remodeling of the former Nora B's in Elm Grove complete, RiverMill Foods opened in its new, larger home late this week.
The restaurant moved from downtown Waukesha to be more centrally located to its catering clients, owner Laurie Runyan said. It's open to the public for sandwiches, wraps, salads, soups, breads and cheesecake, and has added breakfast items at its new place, at 890 Elm Grove Road in the Village Court plaza. »Read Full Blog Post


text:
Top Definition
Modern sportbike rider who performes stunts in public. Frowned upon by responsible riders.
see squid
see squid
"Driving to work I saw a stunta pull a mile long wheelie in rush hour traffic."
автор: Wawa 21 февраля 2003
Trending Now
Can you define these popular missing words?
A motorcycle rider who may or may not be able to do stunts on his bike, but lacks the judgement of when and where to do them.
автор: Baygul 4 февраля 2011
someone who claim they a balla but is broke
kevin is a stunta he aint got no bread
автор: britt 27 марта 2004
See "Wigga", "Wigger" "Icy Hot Stuntaz" "Eminem". Suburban causasian male who attempts to mimic the language and culture of urban hip-hop. Usually spells plurals with a "z". Known to tool around in mom's tricked out "Mishishshi", "Akra" or "Hyundizzay".
Y'all stuntaz need get yo self some bakin' soda and blow, yo. Quit yo frontin', sell some doze rocks and buy yo self some bling. Flip dat bill to the back, my stunta.
автор: Wigga 9 мая 2003
Someone who posses the skills to pay the bills in the sportbike world! A rider who has more control over their bike than most folks have over their own lives! Riders who have practiced and learned stunts that entertain!
Dan Jackson is among the worlds top stunta gods! Right there with Some OG's like Kyle Woods, Starboys, Darius and the likes!
автор: Reckless01 3 февраля 2008


text:
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#15 - herpaherp
Reply 0(11/20/2012) [-]
i thought females had to hit puberty before being able to bear a child?
#16 to #15 - phsycokidx
Reply 0(11/20/2012) [-]
Your username suits you well.
#17 to #16 - herpaherp
Reply 0(11/20/2012) [-]
I was under the impression that girls ovaries had to be prepared to recieve sperm in order to create a zygote and then give birth, whenever the uterus was prepped and no sperm was recieved then the uterus molted the thickened walls causing her period.
Have I learned nothing in biology?
Have I learned nothing in biology?
#18 to #17 - phsycokidx
Reply +2(11/20/2012) [-]
Your understanding of biology is correct. Your understanding of sarcasm is flawed.
#21 to #20 - DoggyBouncer
Reply 0(11/20/2012) [-]
I know right?


text:
TV Ratings: 'Shark Tank,' 'Barbara Walters: Her Story' lead ABC Friday
Fast National ratings for Friday, May 16, 2014.
With CBS done with Friday originals for the season, ABC dominated the night in all measures with the "Shark Tank" finale and a two-hour special dedicated to the retiring Barbara Walters.
Among other Friday notables, NBC's "Grimm" added a few viewers for its finale, while "Hannibal" was up a hair in both viewers and the key demo. The CW had good nights for both the "Hart of Dixie" finale and "Whose Line Is It Anyway," but those numbers may be high enough to suggest preemptions.
On to the numbers...
Among adults 18-49, ABC averaged a 1.6 rating for Friday night, comfortably ahead of the 1.2 rating for NBC in the key demographic. CBS' 0.7 key demo rating was third, followed by FOX's 0.6 rating and The CW's 0.5 key demo rating.
Overall, ABC averaged an estimated 8.38 million viewers and a 5.6 rating/10 share for Friday primetime, far ahead of the 6.07 million viewer and 4.0/7 for CBS. NBC was third for the night with 4.91 million viewers and a 3.2/6, followed by FOX's 2.01 million viewers and 1.3/2 and then the 1.335 million and 0.8/2 for The CW.
8 p.m. - NBC started primetime in first overall with 6.86 million viewers for "Dateline," which was second with a 1.3 rating among adults 18-49. ABC's "Shark Tank" finale was second overall with 6.49 million viewers and won the hour with a 1.6 key demo rating, down from recent 9 p.m. airings. CBS' repeat of "Hawaii Five-0" averaged 5.32 million viewers and a 0.7 key demo rating. The CW's "Whose Line Is It Anyway?" new episode and repeat averaged 1.66 million viewers and a 0.6 key demo rating, ahead of the 1.62 million viewers and 0.4 key demo rating for FOX's "24: Live Another Day" encore.
9 p.m. - The first hour of ABC's "Barbara Walters: Her Story" won the 9 p.m. hour with 8.74 million viewers and also came out on top with a 1.5 rating among adults 18-49. A "Blue Bloods" repeat put CBS in second with 6.02 million viewers and fourth with a 0.7 key demo rating. NBC's "Grimm" finale averaged 5.39 million viewers for third and a 1.3 key demo rating for second. [Lest you want to mock the age of "Her Story" viewers, ABC beat NBC among viewers 12-34 for the hour as well.] FOX's "Kitchen Nightmares" finale averaged 2.4 million viewers and a 0.9 key demo rating, topping the 1.01 million viewers and 0.4 key demo rating for The CW's "Hart of Dixie."
10 p.m. - "Barbara Walters: Her Story" closed primetime with 9.91 million viewers and a 1.6 rating among adults 18-49 for ABC. CBS' "Blue Bloods" repeat was second with 6.88 million viewers and third with a 0.8 key demo rating. On NBC, "Hannibal" averaged 2.475 million viewers and a 0.9 key demo rating.
All ratings information comes from preliminary Fast National Nielsen data, which includes live and same-day DVR viewing. All numbers are subject to change.


text:
Men's Teams
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Welcome to the
Christensen Hall of Fame! This site is dedicated to the athletes,
coaches, and builders that have made a significant impact on the School
of Mines and the athletics department. The accomplishments and
dedication of these these individuals and teams will also be remembered
through the generosity of the Christensen family. Thank you!
CITY, S.D. --- The South Dakota School of Mines Athletics Dept., and the
Hardrock Club are pleased to announce the 2016 Hardrocker Athletic Hall of Fame
inductees: Steve Butherus (football), Jami (Barraclough) Kortan (women's
basketball), Mitch Ruedebusch (cross country and track & field) and the
1971-72 SD Mines men's golf team.
inductees will be honored during a banquet Saturday, Oct. 1, 2016, in the
Christensen Hall of Fame Room at the King Center in Rapid City, S.D., and also will
be recognized during halftime of the M-Day homecoming football game against
Adams State later that night on Dunham Field at O'Harra Stadium.
Steve Butherus (1975-78) was a versatile
player for the Hardrocker football program playing a number of positions, including:
quarterback, running back, wide receiver and defensive back as well as kick and
punt returner.
finished his final season for SD Mines as arguably the most versatile player in
the history of the college. He was a repeater on the All-SDIC and All-District
12 teams and led the nation in NAIA stats in punt returns (19.4 ave.). Butherus
also still holds that record at SD Mines (1977) as well as the school record
for kickoff returns --- averaging 27.1 yards in a season (1977).
Jami Barraclough Kortan (1996-2000) is the all-time
leading scorer for the Lady Hardrocker women's basketball program with 2,422
points and went to four-straight national tournaments which included NAIA
national quarterfinals and semifinals appearances.
The Spearfish native was the 2000 South
Dakota Women's Basketball Player of the Year, was a four-time NAIA All-American
selection, earned NAIA Academic All-American honors in 1999 and 2000, was a
four-time SDIC All-Conference selection and was the 1997 SDIC Rookie of the
holds a number of other Hardrocker school records including: points in a season
(698 in 99-00); points in a game (42 points in 98-99); attempts in a season
(267 in 99-00); free throw attempts in a game (20 in 99-00); field goals made
in a career (1,693 in 96-00); field goals made in a season (262 in 99-00);
field goals made in a game (16 in 98-99); field goal attempts in a career (895
in 96-00); field goals attempted in a season (493 in 99-00); third on all-time
rebounders list with 997; fifth all-time on steals list with 235; 12th
on all-time blocking list with 61.
Mitch Ruedebusch (1990-94) was a member of three
championship cross country teams in his career (one conference championship and
two district championships). He is also a three-time NAIA national cross
country qualifier. In track & field Mitch earned an SDIC conference title
in the men's 5-kilometer race.
The 1971-72 SD Mines men's golf team laid the foundation for
success for several years to follow. The group of Hardrockers golfers, coached
by Bob Hunt, won the SDIC conference and NAIA District 12 tournaments during
the season to advance to NAIA National Tournament. Members of the team
included: Steve Lux, Mark Lux, Jeff Walker, Ralph Wagner and Henry Mott.
Hall of Fame
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text:
The Imperial Electors hold a preliminary meeting at Nuremberg to attempt to choose a King of the Romans. At this meeting, Matthias of Bohemia is preferred to the Archduke Albert, but the Spiritual Electors unite in support of the latter.
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Skip to comments.The wild Rothschild heiress, her rap star lover and the photo that's alarmed her friends
Posted on 02/27/2014 12:28:04 PM PST by C19fan
Pulling hard on a cigarette as she sauntered down the road, the unkempt brunette in the hoodie barely drew a glance from photographers outside Ronnie Scotts nightclub in Soho last week. The flashbulbs duly exploded into action for Kate Moss, Noel Gallagher, Stephen Fry and many more. But what of the girl in the tracksuit and grubby trainers? She would have looked more at home begging for change. It was only when her companion was refused entry to the club, sparking an unseemly argument with door staff, that the penny dropped. This was no beggar; it was Kate Rothschild, mother-of-three and heiress to one of the worlds most illustrious and notorious banking dynasties, with her rapper boyfriend, the extravagantly monikered Jay Electronica.
(Excerpt) Read more at dailymail.co.uk ...
mother of 3 is partying down at nightclubs
who raises the kids, grandma?
Where are her children while she's clubbing with a rapper?
We go on about the families of welfare mothers, but here's Kate Rothschild with three children, Heidi Klum (split last year from the rapper "Seal"), Kevin Federline has six children (some with Britney Spears).
Their kids don't have much better odds than those of Chanterelle the Walmart cashier. They'll be rich, but being rich doesn't save you from addiction, toxic relationships, crime, and misery. Look at the Kennedys!
That dynasty often eliminates their own problems. They let one of their own die in an Arbeitslager during the war when they could have easily retrieved him. She might want to ponder on that.
They have nannys and other servants, unlike the poor you mentioned.
It appears not to help much. Poor kids are at taxpayer-funded daycare. Six of one, half a dozen of the other.
At some point I will sit my three children down and talk with them about the kind of people they should date and marry. The talk won't be politically correct. My children will make their own decisions, but at least they will have been informed.
Looks like she failed to inherit the family brains.
Ask Cher's daughter about the nanny
She used to be a beauty.
Now she's as homely as fells naphtha bar soap.
Exactly when is she "not on mummy duty?"
It's something you have evenings and weekends off from?
I have certainly have spoken to my four.
earning power
nicer than you
from a big nice family who like you
culturally like you
The husband looks very light in the loafers.
He presumably fathered her three children, and now he's shacked up with a model. Lifestyles of the rich and famous. Tell me again how they're different from the "Honey Boo Boo" clan?
Maybe to you. He looks like a handsome young man to me.
The Rothchilds (Rothchildren?) are my cousins, so you'd better watch out. The warning below borrowed from His Holiness's Holy Joel O$teen's daily thread:
"Debate of any kind is not appropriate on a devotional thread. They are closed, i.e. to be treated as if they are occurring behind the closed doors of a church." -Religion Moderator
At least mama June agreed to a commitment ceremony. Honey Boo Boo's bio father, Sugar Bear, has stayed around as the daddy figure and has proved for the family for about a decade. June and Sugar Bear don't have "off duty" days. While they may be horrifically backward, there is a lot of love in the little house by the RR tracks.
You're right, I think. I was referring to the various parentage and shuffling of "partners," but there's a lot to be said for being down in the trenches with the whole family engaged in survival.
Models and rappers and banking heiresses aren't worried about survival.
I told the boys that there are two types of girls to look out for; the ones who want you to take them home from the party, and the ones who want you to take them home to mom and dad. Don't ever confuse the two of them, and stay away from the former.
The sequence of life is: Education, job/career, marriage, home, kids. Do not shuffle the order.
Wouldn't that also apply to girls....there are two kinds of boys....the ones who want to take you home from the party and the ones who want to take you home to meet the folks.
Without adversity, life becomes cheaply held.
Yeah. You don't maintain a 500 year old dynasty by breeding slugs. I'm sure she is now considered a "person of interest" by the Illuminati. :)
It does apply to girls. But I had boys.
"Without adversity, life becomes cheaply held."
During the Civil War children as young as eight were providing for the family. Today they won't do the dishes. I think the lack of a family job makes kids feel they're not worthwhile. If I'm not worthwhile and important with responsibilities, why not do drugs and party all day?
BTW, the government keeps them on your insurance until 26. How times change.
Must have begun taking some powerful ugly pills since her marriage.
Trash with cash
The Rothchild family of story gained their international prominence only a little more than 200 years ago.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Darrell Lea closes for good
The Lea family, owner and operator of the Darrell Lea Chocolate Shops, has found a buyer for the collapsed business, which will see the closure of all remaining stores by Sunday.
Posted Tue 04/09/2012 12:00:00 / Read More »
Darrell Lea shut stores, axes jobs
Almost of half of the country's Darrell Lea stores have had to close their doors as a result of the company entering into administration in July.
Posted Fri 03/08/2012 12:00:00 / Read More »
Darrell Lea up for sale after 85 years
Darrell Lea has been placed into voluntary administration, appointing Mark Robinson, Jack Bournelis and Daniel Walley of PPB Advisory as Voluntary Administrators of the business.
Posted Wed 11/07/2012 12:00:00 / Read More »


text:
Grand Canyon West Rim Deluxe Sunset Helicopter Tour
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Grand Canyon West Rim Deluxe Sunset Helicopter Tour information and booking
Special Offer Book with us and save 6% compared to another travel site!Check prices & availability
Tour description provided by Viator
Take off from Las Vegas on a magical sunset helicopter tour to the Grand Canyon. You'll enjoy a 45-minute helicopter flight each way, land at the Grand Canyon for a champagne picnic while you watch the changing colors of sunset, then fly low over the famous neon-lit Las Vegas Strip on your return.
After limousine pick-up from your Las Vegas hotel, you will be taken to board your helicopter. You will fly by Lake Las Vegas, Lake Mead and Hoover Dam as your helicopter flies to the West Rim. During your flight, headphones provide a recorded commentary about the Grand Canyon and its surrounds. The flight between Las Vegas and Grand Canyon West Rim is approximately 45 minutes each way.Landing on Hualapai Indian land for a champagne picnic, you can admire the ever-changing colors of the canyon walls in the glow of twilight. Your pilot/guide will be happy to answer any questions you may have about the area or your helicopter flight as you watch the sun set over the horizon.Your Sunset Helicopter Tour concludes with a low-level flight over the west side of the famous Las Vegas Strip. Flying from the Stratosphere Hotel to New York-New York, you will have a great view over the extravagant casinos and hotels of Vegas lit up for the night. On landing your limousine will be waiting to return you to your hotel.There is a maximum capacity of 6 people per helicopter plus your pilot.
For a roomier experience, upgrade your flight to an EC-130 helicopter which allows for more leg room and can accommodate more weight per seat. See Additional Info for more details on weight restrictions.
Please note: the listed price does not include a US $10 per person fuel surcharge, payable at the time of tour check-in.
What's included
- 45-minute (approx.) flight each way (helicopter based on option selected)
- Picnic meal
- Glass of champagne
- Hotel pickup and drop-off by limousine
What isn't included
- Gratuities (optional)
- The listed price does not include a us $10 per person fuel surcharge, payable at the time of tour check-in.


text:
It is a tremendous honor and privilege to have been elected to serve as the President of the New England Surgical Society for this past year. The Society has a long and distinguished history and has been an important contributor to the development of surgical science and education in New England. I feel particularly humble and proud as an immigrant, not only to New England but to the United States as well. New England took me in and provided a professional home, and the United States took me and my family in and enabled us to survive.
Paul Friedmann, MD
Complexity and chaos (after Ralph D. Stacey). Agreement and certainty matrix for decision making and control. Ralph D. Stacey is professor of management at the University of Hertfordshire, Hertford, United Kingdom. The matrix comes from Stacey's book, Strategic Management and Organizational Dynamics. London, England: Pitman Publishing; 1996. The plus and minus signs indicate the degree of agreement and certainty. The farther out on the axes one gets, the less agreement and certainty there are. Where there is little agreement and little certainty, there is chaos.
Maimonides by Ben Shahn at Tufts University School of Medicine.
Arnold J. Toynbee as a student at Balliol College, Oxford University, Oxford, England. Reprinted with permission from Bodleian Library, Oxford University.
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Call for Papers - Rethinking Jihad: Ideas, Politics and Conflict in the Arab World and Beyond
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Call for Papers
International Conference "Rethinking Jihad: Ideas, Politics and Conflict In the Arab World and Beyond" The Centre for the Advanced Study of the Arab World
The University of Edinburgh, 7-9 September 2009
Especially since 11 September 2001, the notion of 'jihad' has assumed centre-stage in public and academic discourses on Islam, Muslims, and the Arab world, particularly as a byword for terrorism and violence.
But clearly jihad has meant different things to different people at different times, whether as theory, as action or as metaphor. As a timely exploration of this diversity, the Centre for the Advanced Study of the Arab World (CASAW) is convening a major international conference on the subject of jihad in its multiple dimensions. The conference has three overarching goals. The first is to bring together academics and others from a variety of disciplines and specialisations to generate an in-depth discussion of jihad in its practical, theoretical, historical, juridical and symbolic dimensions. It is hoped that by drawing on a diversity of perspectives (methodological, historical and geographical) the conference will contribute to a deeper and more critical understanding of jihad. The second goal is to reflect critically on the importance of jihad, however defined, to the study of the Arab and Islamic worlds: to what extent is jihad a useful analytical concept? Have students of Islam and the Arab world minimised or overstated its importance? How should jihad be located in future research agendas? Finally, the conference will seek to engage with the broader knowledge community and explore current understandings and representations of jihad within policy and media circles internationally. It will critique these representations, as well as explore ways in which academics might contribute to an improved understanding and contextualisation of jihad in public discourse.
The conference will combine keynote addresses and panel discussions over three days at the University of Edinburgh. Confirmed speakers currently include:
Prof. John L. Esposito (Georgetown University), Prof. Fred Halliday (Barcelona Institute for International Studies), Prof. Carole Hillenbrand (University of Edinburgh), Prof. Rudolph Peters (University of Amsterdam), Prof. Tariq Ramadan (University of Oxford), Dr. Hasan al-Turabi (PCP, Sudan), Dr. Roxanne Varzi (University of California, Irvine), Prof. Sami Zubeida (Birkbeck, University of London)
Paper proposals for panels are invited from scholars and graduate students in all fields of the humanities and social sciences, including area studies, history, religious studies, political science, law, international relations, anthropology, cultural studies, comparative literature, and sociology . Papers addressing the topics detailed below are particularly encouraged, but we aim to make the conference as inclusive as possible. As such, any proposal dealing with jihad (broadly defined), or related topics will be welcome.
1. Jihad in History How has jihad evolved in the centuries since the Qur'an, both doctrinally and in practice? What factors have influenced this evolution? Are the ideas and political actions associated with jihad unique to Islam, or representative of more general religious and political developments? To what extent do particular readings of jihad in Islamic history inform contemporary debates and practices?
2. Jihad Theory How much consensus has there been among Muslim intellectuals about jihad? What are/have been the main areas of convergence and disagreement? How central is, or has been, the issue of jihad to Muslim theological and intellectual discourses? Papers may also discuss the role of, or potential for, interfaith dialogue on the issue of jihad.
3. Jihad and Martyrdom What is the relationship between these two categories, and how central has the idea of martyrdom been to jihad? Papers engaging with this theme could also compare notions of martyrdom in other religions.
4. Jihad in non-Muslim Majority Societies How has jihad been interpreted and practiced in non-Muslim majority societies? How does this compare to the role of jihad in the Arab and Islamic worlds? How do transnational intellectual, institutional and cultural links influence the way Muslims in the West conceptualise jihad?
5. Jihad, Language and Popular Culture What is/has been the resonance of jihad within language? How have its meanings and associations shifted over time? How has jihad been represented at the level of popular culture, including within literature, poetry, the press, television and film?
6. Jihad and Social and Political Action What has been the role of jihad in political mobilisation and activism? What have been the links between ideas and action? How has jihad informed or been reflected in social practice?
7. Non-Muslim Approaches to Jihad How have academic, media and policy communities shaped public perceptions of jihad in non-Muslim majority contexts? To what extent have ideas on jihad shaped perceptions of Islam, Arabs and Muslims more generally? How are jihad and related topics taught as part of Middle East or Islamic studies programmes in universities and can this be improved?
8. States, Law and War To what extent does jihad function as an international legal or normative framework? How compatible is it with international law? What are/have been the relationships between jihad, violence, terrorism and war? How have shifting conceptions of authority affected jihad? How has globalisation impacted on jihad as theory and as practice?
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text:
New owners Justin Aprahamian keeps Sanford restaurant sublime
It might be natural to worry that Sanford, a bastion of continuity for more than two decades, would change too much after its sale in late 2012. My only worry, though, was that it might not change enough.
After 23 years on the lower east side, operating a premier fine-dining restaurant with a national reputation, chef Sanford D'Amato and his wife, Angie, sold their restaurant to their chef de cuisine. »Read Full Article(4)
Eat words: Edible Books Show at Woodland Pattern on April 6
Maybe you like to chew on what you've read. Woodland Pattern Book Center, 720 E. Locust St., is having its annual Edible Books Show on April 6, a display of book-related works made of food.
Families, students, chefs and others still can submit entries by calling the bookstore to reserve spots. »Read Full Blog Post
Foodie things to do this week in Milwaukee
Fine foods
That aroma in the air might be spring. On the other hand, it might be from this week's tasty food-related events. »Read Full Article


text:
Safety and Pharmacology of SNX-5422 Plus Everolimus in Subjects With Neuroendocrine Tumors
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Drug: SNX-5422
Phase 1
|Study Type:
|Study Design:
|Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase 1, Open-label, Dose-escalation Study of SNX 5422 and Everolimus in Subjects With Neuroendocrine Tumors.
- Number of patients with dose limiting toxicities [ Time Frame: First 28 day cycle ] [ Designated as safety issue: Yes ]Number of patients with dose limiting toxicities defined as adverse events or laboratory abnormalities of Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 ≥ Grade 3 that are not clearly related to disease progression or delay by more than 4 weeks in receiving the next scheduled cycle due to persisting toxicities and attributable to the combination of SNX-5422 and everolimus despite optimal medical supportive management.
- Number of patients with adverse events as a measure of tolerability [ Time Frame: Every 4 weeks ] [ Designated as safety issue: Yes ]Frequency and severity of adverse events
- Changes in ECG, vital signs, laboratory or physical examination [ Time Frame: Every 4 weeks ] [ Designated as safety issue: Yes ]Changes in ECG, vital signs, laboratory or physical examination from baseline
- Tumor response [ Time Frame: Every 8 weeks ] [ Designated as safety issue: No ]Measurements from tumor imaging within 1 month prior to the screening visit will be used as the baseline assessment. This assessment will be performed using Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Follow-up imaging of known sites of the disease, preferably by CT scan, will be performed at intervals appropriate to the subject's disease and clinical findings.
|Study Start Date:
|February 2014
|Estimated Study Completion Date:
|February 2017
|Estimated Primary Completion Date:
|October 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: SNX-5422
Open-label administration of SNX-5422 capsules dosed in the morning once every other day (qod) for 21 days (11 doses), followed by a 7 day drug free period. Dose escalation will be based on safety defined as 1 or less dose limiting toxicities during the first 28 day cycle at any dose level. Dose escalation will not exceed a dose of 100 mg/m2 SNX-5422 qod even if the MTD has not been identified. Subjects will receive daily oral everolimus in the PM about the same time every day for 28 days.
Drug: SNX-5422
Capsule dosed every other day for 21 days out of a 28 day cycle. Dose escalation based on safety not to exceed a dose of 100 mg/m2. Maintenance therapy of SNX-5422 at the MTD will be allowed for all patients not experiencing significant toxicity.
Detailed Description:
Heat shock protein 90 (Hsp90) plays a central role in the maturation and maintenance of numerous proteins, for example HER2 and mutated EGFR, that are critical for tumor cell viability and growth; SNX-5422 is a pro-drug of SNX-2112, a potent, highly selective, small-molecule inhibitor of the molecular chaperone heat shock protein 90 (Hsp90). Hsp90 has been found to be expressed in 95% of subjects with pancreatic neuroendocrine tumors.
This study will determine the MTD of SNX-5422 when given in combination with everolimus in patients with neuroendocrine tumors.The clinical starting dose of 50 mg/m2 qod for SNX-5422 in combination with daily everolimus is 50% of the SNX-5422 qod mono-therapy MTD. The choice to continue once every other day SNX-5422 dosing is based on the safety and efficacy profiles from prior studies, so that drug holidays are interspersed into weekly dosing. The planned subsequent dose levels are 75% and 100% of the SNX-5422 qod mono-therapy MTD.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males or non-pregnant, non-breastfeeding females 18 years-of-age or older.
- Archived neuroendocrine tumor sample or biopsy sample (will also be used for genetic testing).
- Pathologic evidence of chemo-resistant Small Cell Lung cancer (relapse <90 days after 1st line), chemo-sensitive Small Cell Lung Cancer (relapse >90 days after first line), locally advanced metastatic neuroendocrine tumor of gastro-entero, pancreatic, pulmonary (other than Small Cell Lung) or thymic origin, or advanced renal cell carcinoma for which everolimus is indicated.
- Measurable (RECIST) indicator lesion not previously irradiated.
- Life expectancy of at least 3 months.
- No more than 4 prior lines of systemic anti-cancer therapy.
- Karnofsky performance score ≥70.
Adequate baseline laboratory assessments, including
- Absolute neutrophil count (ANC) ≥1.5 x 109/L.
- WBC >3000/microliter
- Platelet count of ≥100 x 109/L.
- Total bilirubin level ≤1.5 times institutional upper limit of normal (ULN), alanine aminotransferase or aspartate aminotransferase ≤2 x ULN
- Hemoglobin ≥9 mg/dL.
- Creatinine <1.5 X upper limit of normal or estimated plasma creatinine clearance of ≥40 mL/min
- Signed informed consent form
- Recovered from toxicities of previous anticancer therapy
- Subjects with reproductive capability must agree to practice adequate contraception methods.
Exclusion Criteria:
- Subjects in whom everolimus is contraindicated.
- Subjects with clinically significant interstitial lung disease, or obstructive disease without sufficient reserve
- Carcinoid with hormone related symptoms
- Neuroendocrine cancer of the thyroid or thymus.
- Rare pancreatic neuroendocrine cancers such as, insulinomas, glucagonomas, gastrinomas.
- Prior treatment with any Hsp90 inhibitor.
- Prior failed treatment with mTOR inhibitors
- CNS metastases that are symptomatic and /or requiring escalating doses of steroids.
- Major surgery or significant traumatic injury within 4 weeks of starting study treatment.
- Conventional chemotherapy or radiation within 4 weeks.
- Palliative radiation within 2 weeks.
- The need for treatment with medications with clinically-relevant metabolism by the cytochrome P450 (CYP) 3A4 isoenzyme within 3 hours before or after administration of SNX-5422
- Screening ECG QTc interval ≥470 msec for females, ≥450 msec for males.
- At increased risk for developing prolonged QT interval, including hypokalemia or hypomagnesemia, unless corrected to within normal limits prior to first dose of SNX-5422; congenital long QT syndrome or a history of torsade de pointes; currently receiving anti-arrhythmics or other medications that may be associated with QT prolongation.
- Patients with chronic diarrhea or with Grade 2 or greater diarrhea despite appropriate medical management.
- Gastrointestinal diseases or conditions that could affect drug absorption, including gastric bypass.
- Gastrointestinal diseases that could alter the assessment of safety, including irritable bowel syndrome, ulcerative colitis, Crohn's disease, or hemorrhagic coloproctitis.
- History of documented adrenal dysfunction not due to malignancy.
- Known seropositive for human immunodeficiency virus (HIV) or hepatitis C virus (HCV).
- History of chronic liver disease.
- Active hepatitis A or B.
- Current alcohol dependence or drug abuse.
- Use of an investigational treatment from 30 days prior to the first dose of SNX-5422 and during the study.
- Glaucoma, retinitis pigmentosa, macular degeneration, or any retinal changes detected by ophthalmological examination.
- Other serious concurrent illness or medical condition.
- Psychological, social, familial, or geographical reasons that would hinder or prevent compliance with the requirements of the protocol or compromise the informed consent process.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02063958
|United States, Arizona
|Mayo Clinic
|Scottsdale, Arizona, United States, 85259-5499
|United States, California
|Stanford Medicine
|Stanford, California, United States, 94305
|United States, District of Columbia
|Georgetown University Medical Center
|Washington, District of Columbia, United States, 20007
|United States, Maryland
|Center for Cancer Research, National Cancer Institute
|Bethesda, Maryland, United States, 20892
|United States, New Jersey
|hackensack University Medical Center
|Hackensack, New Jersey, United States, 07601
|Responsible Party:
|Esanex Inc.
|ClinicalTrials.gov Identifier:
|NCT02063958 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 13, 2014
|Last Updated:
|August 15, 2016
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Esanex Inc.:
Neuroendocrine tumor
Additional relevant MeSH terms:
Neuroendocrine Tumors
Carcinoid Tumor
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Neoplasms, Glandular and Epithelial
Antineoplastic Agents
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antineoplastic
Antifungal Agents
ClinicalTrials.gov processed this record on September 23, 2016


text: e-dukasi.net opened on 12.8.2002 and this domain is 14 years, 1 month old. We see that e-dukasi.net is using Google Adsense to monetize and , 2402095 Alexa Rank and Country rank shows us how good and useful this site is.It is well known webmasters care about W3 Validator and fortunately W3 didn't find any error and warning on e-dukasi.net. It is important for every website to open quick and be smooth while surfing. We see this site opens in 2121 milliseconds and it isn't a good score at all, you can make your site faster by compressing your scripts and stylesheets. e-dukasi.net registered under TUCOWS DOMAINS INC. and Its nameservers are ns1.e-dukasi.net and ns2.e-dukasi.net.On our researches we see e-dukasi.net doesn't get any visitor from search engines but we think this website is getting visitors directly. This website doesn't have any keyword, we think they should put at least one or two keywords. We see e-dukasi.net doesn't have DMOZ record that is why we don't think this site is secure to surf but since DMOZ wants money to add your site to Dmoz we can't say this site is 100% secure or not.We see that your website gets most of the users with these missed types;d-dukasi.net, e-ukasi.net, e-cdukasi.net, e-dkasi.net, e-d7ukasi.net, e-duasi.net, e-duikasi.net, e-duksi.net, e-dukqasi.net, e-dukai.net,


text:
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
Adapting to Evolving Business Environments Is...
Quadruple Helices Appear To Have Role...
Synthetic Genomics and Integrated DNA Technologies (IDT) are combining their expertise through an agreement to manufacture, commercialize, and market small synthetic gene products. The collaboration will combine IDT's custom oligo manufacturing capabilities, including its recently released gBlocks gene fragment products, with Synthetic's technologies for assembling small gene constructs, to produce custom synthetic double-stranded nucleic acids up to 5 kb in length.
"Through this collaboration we plan to apply Synthetic Genomics' cutting-edge technologies to create more affordable, efficient gene synthesis products that can be delivered more quickly to the synthetic biology community," states Joe Walder, Ph.D., IDT's founder and CEO.
IDT is specialized in the manufacture of custom nucleic acids for the academic, biotech, clinical diagnostics, and pharmaceuticals industries. The firm's primary business is the manufacture of custom primers, probes, and genes for research and diagnostic applications.
Founded in 2005 and headed by J. Craig Venter, Ph.D., SGI is exploiting genomic technologies in diverse fields including environmental genomics, microbiology, biochemistry, bioinformatics, plant genomics, genome engineering, synthetic biology, and climate change. Key ongoing collaborations include an algal biofuels alliance with Exxon Mobil, a microbial-enhanced hydrocarbon recovery and conversion program with BP, and projects focused on clean water and improved food and nutritional products.
Synthetic Genomic Vaccines, a company co-founded by SGI and the J. Craig Venter Institute, is separately engaged in the development of synthetically derived vaccines. In October 2011 SGI and Mexico-based investment and management company Plenu established Agradis, to focus on the development of sustainable crops and agriculture products.
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Monolith Financial GroupAdditional Locations
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text:
tea farm?>
Nope it wasn't a tea farm. It's located in the former high securiy zone in a war tone area, what is now released for resettlement and people are yet to resettle in this area. In Sri Lanka tea generally grows in high land not in low land (close to see level) like this. Thanks a visiting my gallery and make valuable comments :).
Very nice view in the country.
Sincere greetings from Taiwan to Sri Lanka.
Very nice picture and place!
Greetings from Portugal, Mário Eloi Castro
Very nice and interesting photo - Like
Thanks a lot Enson, Mário Eloi Castro and Galadriela :).
Very nice prespective! LIKE Greetings from Poland, Krystyna.
Thanks a lot Krystyna :).
Like nº 5.
Great photo.
Nice place.
Salud2...from Spain...
Thanks a lot Salud2 :).
Very beautiful
Very good perspective! Like 7! Best wishes, Stefan
Thanks a lot Javad Ale Ali and Stefan :).
Photo taken in Jaffna, Sri Lanka


text:
Top Definition
I grample when I am in need of therapy.
додав Shayn 26 Червня 2003
Trending Now
Can you define these popular missing words?
Verb. To over-poeticize in an especially crass way.
"I had an idea" could be grampled to "The idea came to me like a locker room full of teenaged boys".
додав Stiphy 05 Січня 2013


text:
Voices Saved from Vanishing
Vivian Grosswald Curran
University of Pittsburgh - School of Law
June 1, 2009
University of Pittsburgh Law Review, Vol. 70, p. 435, 2009
U. of Pittsburgh Legal Studies Research Paper No. 2009-18
Jurists Uprooted: German-speaking Émigré Lawyers in Twentieth-century Britain examines the lives of eighteen émigré lawyers and legal scholars who made their way to the United Kingdom, almost all to escape Nazism, and analyzes their impact on the development of English law.
Number of Pages in PDF File: 30
Keywords: Jurists Uprooted: German-speaking Émigré Lawyers in Twentieth-century Britain, Jack Beatson, Reinhard Zimmermann, Nazism, comparative law, international law, Roman law, English law, British legal scholarship, émigré lawyers, émigré legal scholars, exile
Date posted: June 26, 2009
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text:
Anne EmeryMarch 09,2013Anne Emery Rites
CASTLETON The memorial service for Anne Emery, 71, who died Jan. 22, 2013, was held March 8, at Fellowship Bible Church in Castleton.
Pastor John Lonaker officiated.
Music was provided by Ron and Linda Splatt, Mel and Darla Patch, with piano selections by a brother, Steven Cushman.
A reception followed at the Trak-In.
Arrangements were under the direction of the Durfee Funeral Home.MORE IN ObituariesDavid R. Burton
BRIDGEWATER CORNERS David R. Burton, 73, died Sept. Full StoryAnna M. Johnson
MIDDLEBURY Anna Maria Johnson, 90, died Sunday, Sept. Full StoryOscar F. Sodergren
SCHENECTADY, NY The Rev. Full Story
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text:
I think I may have PCOS but my appointment with my infertility doctor (not an RE, just an OB/GYN with a focus in infertility & high risk) isn't until Feb 7th. How exactly were you diagnosed with PCOS? What symptoms did you have? I feel like I have several of the classic symptoms, but they are so generalized that it could be anything (such as weight, acne, oily skin, irregular cycles, miscarriages, etc).
My husband and I have been TTC for 6 1/2 years and have miscarried twice, the 1st at 5w4d and the other at 6w3d. I have a high suspicion I needed progesterone supplements. We have no live births, and no other pregnancies.
When I first went to the doctor, I did take a progesterone blood test on day 21 and it showed that I had not ovulated so I was given Clomid 50mg. I did not ovulate on that dose, so it was bumped up to 100mg. I did ovulate on that dose. We did conceive the first time with Clomid, but our 2nd pregnancy was natural. When I was on Clomid I was temping and one of the months on 100mg I did not ovulate...even though I got pregnant a different month on 100mg. Is that normal?
My cycles used to be anywhere from 27 days to 50+ days. Now they are a little more regular, around 28-36 days on average but I still don't think I ovulate regularly. I just started BBTing again after a long 2 year break since our last miscarriage so I can't say whether or not I'm ovulating at all yet. We had given up, but decided to try again. I haven't seen a fertility doc in over 2 years and want to relearn all of the possible issues I might have so I feel knowledgeable discussing everything with the doctor and know what tests to ask for.


text:
Import prices up in December
January 15, 2003
The U.S. Import Price Index increased 0.7 percent in December. The increase was largely attributable to an upturn in petroleum prices.
The index for imports, which recorded only two monthly decreases in 2002, resumed an upward trend in December. Led by volatile petroleum prices, overall import prices rose 0.7 percent last month after falling 1.0 percent in November.
The petroleum index, which had decreased in the previous two months, rose 7.4 percent in December. Last month's increase was the largest since the index rose 12.7 percent in April. The price index for nonpetroleum imports also increased in December, edging up 0.1 percent after dipping the same amount in November.
The Export Price Index decreased 0.2 percent in December, after rising 0.1 percent in the previous month.
These data are a product of the BLS International Price program. Learn more in "U.S. Import and Export Price Indexes - December 2002" (PDF) (TXT), news release USDL 03-13.
Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Import prices up in December on the Internet at http://www.bls.gov/opub/ted/2003/jan/wk2/art03.htm (visited September 29, 2016).
Recent editions of Spotlight on Statistics
A look at healthcare spending, employment, pay, benefits, and prices
As one of the largest U.S. industries, healthcare is steadily growing to meet the needs of an increasing population with an increasing life expectancy. This Spotlight looks at how much people spend on healthcare, current and projected employment in the industry, employer-provided healthcare benefits, healthcare prices, and pay for workers in healthcare occupations.
Employment and Wages in Healthcare Occupations
Healthcare occupations are a significant percentage of U.S. employment. Some of the largest and highest paying occupations are in healthcare. This Spotlight examines employment and wages for healthcare occupations.
Fifty years of looking at changes in peoples lives
Longitudinal surveys help us understand long-term changes, such as how events that happened when a person was in high school affect labor market success as an adult.


text:
Fort Collins Aglow to meet Sept. 14
Fort Collins Aglow will meet at 9 a.m. Sept. 14 at Risen Hope Church, 1621 W. Harmony Road.
The group will have a pot luck brunch, followed by the meeting. Speakers will be Howard and Betty Skinner. The Skinner's entered full-time ministry in 1951, and have since pastored and traveled the world in missionary evangelism. They recently published a book, "Secrets to Our Supernatural Walk with God."
All ages and guests are welcome. For more information, call (970) 532-3117.
Community Bible Study to begin Sept. 9
A Community Bible Study on the books of Hebrews and Deuteronomy will begin Sept. 9 and run for 30 weeks.
The CBS meets from 7-8:30 p.m. Mondays at St. Paul's Congregational Church, 43rd Avenue and 16th Street.
The first 18 weeks will be spent studying Hebrews, focusing on foreshadowing of Jesus as high priest. The following 12 weeks will be dedicated to the study of Deuteronomy, the story of Moses working with God to lead a small nation.
The study will integrate historical records and seeing Jesus as savior, as well as in his humanity.
The CBS is an "every person's" study, meaning that participants are welcome regardless of background, education, church involvement, ethnicity or economic status.
For more information, contact Liz at (970) 630-4544 or Bill at (720) 308-4386.
Staff reports


text: Infernal conquest was formed in 2011 with the basic idea of creating raw underground Black Death Metal. Infernal Conquest's first release is a demo cd entitled "Torture Campaign" which consists of 6 filthy and cruel tracks. Infernal Conquest is currently working on a second as yet untitled release, and preparing for live rituals.


text:
Pico de São Tomé
|Pico de São Tomé
São Tomé Island, São Tomé and Príncipe
|Highest point
|2,024 m (6,640 ft) [1]
|2,024 m (6,640 ft) [1]
|Country high point
|0°16′03″N 6°32′36″E / 0.26750°N 6.54333°ECoordinates: 0°16′03″N 6°32′36″E / 0.26750°N 6.54333°E [2]
|São Tomé Island, São Tomé and Príncipe
|Age of rock
|Mountain type
|Shield volcano
|Last eruption
Pico de São Tomé is the highest mountain in São Tomé and Príncipe at 2,024 metres. It lies just west of the centre of São Tomé Island in the Obo National Park. The second highest point, Pico Ana Chaves, lies to its south east. The mountain is forested and accessible only on foot.
The entire island of São Tomé is a massive shield volcano which rises from the floor of the Atlantic Ocean, over 3,000 m (10,000 ft) below sea level. It formed along the Cameroon line, a linear rift zone extending from Cameroon southwest into the Atlantic Ocean. Most of the lava erupted on São Tomé over the last million years has been basalt. The youngest dated rock on the island is about 100,000 years old, but numerous more recent cinder cones are found on the southeast side of the island.
- ^ a b "Pico de São Tomé" on Peakbagger.com Retrieved 29 September 2011
- ^ "Pico de Sao Tome" on Africa Ultra-Prominences Peaklist.org, retrieved 29 September 2011
See also[edit]
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Event Type: Adult Program
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