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The basic idea: Surround Alex Olah – a promising if not inconsistent center – with four perimeter guys and hope to compete with elite opponents. Olah shot only 42 percent in his freshman season, and would arguably face more pressure than any other player as the Collins era opened.
For five games, Olah failed to even approach the promise. On Monday against Gardner-Webb, he finally delivered — scoring a career-high 18 points and adding five blocks in NU's 72-59 victory.
"Alex Olah was the star of the game," Chris Collins said. "He gets a bad rap for not being as physical as he should. But I'm really proud of Alex. He took his time, and we went to him."
Drew Crawford, Sanjay Lumpkin and Alex Olah also reached double-digit point totals, as the Wildcats improved to 4-2 before their trip to Las Vegas.
Like Friday's win over IUPUI, Northwestern had some initial struggles — with no offensive rhythm and continued foul trouble. But unlike that game, they closed quickly, making 18 of their 27 second-half field goal attempts en route to the comfortable win.
NU worked on the proverbial inside-out game, beating Gardner-Webb despite only three makes from behind the arc. The Wildcats opened the second half leading 28-25, but established quality looks to avoid an upset bid.
"The way we moved the ball in the second half was great," Crawford said. "… They started to pressure us a little bit more, but we stayed composed and we found the open man."
That often meant Olah, who made five of his six second-half shots in what was easily his best performance of the season. With 1:01 remaining, he iced the game with a layup that brought Northwestern's lead to 68-59.
"The coaches were on me to be more aggressive in the post," Olah said. "Every time I get the ball in there, I have to make a move."
Collins also preached the importance of effort: "If you're ready to play, you will lose." That continues to resonate, with another strong defensive effort against Gardner-Webb. The Runnin' Bulldogs shot just 35 percent from the floor – making two of 14 threes – and failed to convert on the Wildcats' early miscues.
Sanjay Lumpkin, meanwhile, had his least effective game of the season and was ejected after committing a flagrant 2 foul with 2:47 remaining. Contrary to initial reports, he is eligible to play in NU's upcoming game against Missouri.
"I'm disappointed in the play by Sanjay," Collins said. "It's not something we can have at that point of the game."
"I've been kicked out of a game, so I just helped him along to move on from it," Crawford added.
Winners of three straight, Northwestern travels to Las Vegas for games against Missouri and UCLA. And in spite of two early losses – and more uninspired games – the team can prove its mettle later this week.
"We're capable of being a great team," Crawford said, "so I think just the opportunity to go out there and play two great teams is going to be great for us. That's exciting in itself."
Minutes earlier, Alex Olah joked: "Too bad I'm not 21."
As long as he matures on the floor, no one's complaining. At 4-2, the Wildcats are set for their season-defining stretch.


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Price per Night Range
Bedrooms (min)
Sleeps (min)
1 Calas de Mallorca Pet Friendly Vacation Rentals were found matching your criteria.
4 Bedroom, 2 Bathroom, Sleeps 7
Calas de Mallorca, Balearic Islands, Spain
Description: Single-family house "Marí", built in 2000. 1 km from the centre of Calas de Mallorca, 500 m from the sea, in a cul-de-sac. For shared use: swimming...
$154 - $280 /night
$1078 - $1960 /week
This map is intended to be used as a reference only.
Available Unavailable Night Min.

subset: commoncrawl


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A few months before Jackson's 3rd birthday he was diagnoised with Oligoarthritis Juvenile Idiopathic Arthritis and Uveitis. Our lives would be forever changed and I could have never prepared for what we were about to go thru!
http://ourarthritisjourney.proboards.com/A forum for parents and families dealing with the diagnosis of Juvenile Arthritis


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640 N La Salle Dr,Chicago, IL 60654 | Map
1038 N La Salle Dr,Chicago, IL 60610 | Map
869 W Buena Ave,Chicago, IL 60613 | Map
Wedding Photography, Engagement Photography, Trash the Dress Photography, Family Photography, Kid... Read More
410 S Michigan Ave,Chicago, IL 60605 | Map
4641 North Broadway,Chicago, IL 60640 | Map
Welcome to Kustom Art Studios! We service all of Chicagoland with custom airbrush art on any text... Read More
407 N Elizabeth St,Chicago, IL 60642 | Map
Zack Burris, Inc. has been crafting images in the Chicago based studio for agencies, designers an... Read More
300 W Superior St,Chicago, IL 60654 | Map
1461 W Fullerton Ave,Chicago, IL 60614 | Map
Prints Unlimited is the most affordable custom picture frame shop in Chicago. With 35 years of ex... Read More
140 E Walton Pl,Chicago, IL 60611 | Map
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Award Winning Chicago Photographer for Designs in Architecture, Interiors, Landscape Design, and ... Read More
500 N Michigan Ave #602,Chicago, IL 60611 | Map
Call Today!
Award-winning photojournalists Josh and Jenn of Jobst Media are among the top 5% of wedding photo... Read More
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Classes in water color oil sculpture, open workshops with models over 60 hours per week. Read More
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Professional photographer Isi Akahome offers high quality photography in the Chicago, IL area. Is... Read More
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Dove's Photography specializes in event and wedding photography in Chicago, IL.
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We offer Pick up, Delivery, Home or Office Consultation, Installation, We have the Largest Select... Read More
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Richard Norton Gallery is always seeking good examples of American and European Impressionist and... Read More
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Often, photography is focused on the milestone moments. Maternity photos, newborn photography and... Read More
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Chicago Photojournalistic and Documentary Wedding Photography. Mark Trela Photography is a husban... Read More
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We specialize in teaching the Meisner Approach to Acting and are certified to teach it by master ... Read More
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Located in the Chicago land area since 1979, we are a Commercial Printer with high end Digital ca... Read More
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Richter Studios is a pioneer in the digital realms of cinema and photography. Since 1997, we have... Read More


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A woman who will take care of you and all your friends when you're drunk.
Thank goodness Mama Cass was there with us last night or I would have stayed in that ditch and you would have suffocated on your tiquilla and chicken taco barf.
โดย ckredhead 10 เมษายน 2010
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The Rich Rodriguez era in Michigan was defined by an explosive offense and an inept defense that led to his dismissal.
In 2010, the Wolverines defense hit rock-bottom. They gave up 35 points a game and needless to say, they couldn't stop anybody from scoring on them. This led to many unnecessary losses.
When Brady Hoke was chosen to be the head coach of the Michigan Wolverines in January 2011, he hired his friend Greg Mattison. As many people know, Mattison was the defensive coordinator of the famed Baltimore Ravens defense.
With the combined efforts of Hoke and Mattison, the Wolverines defense once again became respectable, giving up just 17 points per game. Michigan's win/loss record reflected their much-improved defense, as they went 11-2 and won the Sugar Bowl.
But that was 2011. How will year two go in Greg Mattison's defense? How will Michigan replace some key departures on the defensive line?


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Hestra Pullover Mitt
Retailers' Descriptions
Here's what other sites are saying:
Free Shipping. Hestra Pullover Mitt DECENT FEATURES of the Hestra Pullover Mitt Nylon pull strap Snow lock Attachment for hestra handcuffs The SPECS Construction: Wind / waterproof breathable triton / polyamide fabric Grip dots on palm This product can only be shipped within the United States. Please don't hate us.
- Moosejaw
The Hestra Pullover Mitt is a shell mitt developed with Swedens national alpine team. Used as a warming outer layer outside the basic glove. Also provides complete protection against wet snow and rain. Easy to roll up in a pocket and pull out in the event of bad weather.
- CampSaver.com
Hestra Pullover Mitt
previously retailed for:
$64.95 - $69.95
$64.95 - $69.95
The Hestra Pullover Mitt is not available from the stores we monitor. It was last seen March 28, 2014 at Moosejaw.
If you're looking for a new waterproof glove/mitten, check out the best reviewed current models.


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2012's Top 10 Country Albums
This year's swath of country albums were a diverse collection of contemporary pop, new rough-edged sounds and throwbacks to the genre's roots. Mega releases from the biggest stars filled country radio and vied with underrated albums from new artists and legends. All this made picking a list of the Top 10 albums difficult in spots (I hated having to leave off Lee Brice's "Hard 2 Love") and easy in others (Dwight Yoakam was an obvious number one).
Here's my take on the year's top 10 - records that I've enjoyed from the first spin and have returned to throughout the year. Click here to listen to a Spotify playlist with all of these albums. »Read Full Blog Post(1)
Justin Moore, Randy Houser and Josh Thompson playing The Rave Nov. 29
Justin Moore, pictured here opening for Eric Church at the Bradley Center last October, is returning to Milwaukee as a headliner in November. Journal Sentinel photo by Michael Sears. »Read Full Blog Post
De-lovely cast lifts Cole Porter revue
Summing up Cole Porter, Stephen Sondheim recently wrote that "technically, in both music and lyrics, no one is better than Porter and few are his equals." With all due apology to W.S. Gilbert, nobody wrote better list songs. Nobody wrote double entendres that are so clever and fun. And only a select few have ever written love songs that can match the likes of "So in Love."
All of which goes a long way toward explaining the ongoing appeal of a Porter revue like "Red, Hot and Cole." Debuting in 1989, it was staged at Elm Grove's Sunset Playhouse in 1992 and at the Broadway Baby Dinner Theater in 1996. Now it's back at Sunset, in a production directed and choreographed by Elaine Parsons Herro, who also co-directed the Broadway Baby version. »Read Full Article
Burnhearts, ex-Roots chefs want to open a restaurant in former Mama DeMarinis in Bay View
The owners of Burnhearts bar are seeking a loan from the Milwaukee Economic Development Corp. to turn the former Mama DeMarinis building in Bay View into a restaurant with the ex-Roots chefs, now cooking at Odd Duck.
The nonprofit lender will consider the request at its Tuesday meeting. »Read Full Blog Post(2)
Tosa All-City Read program picks 'Rocket Boys,' 'Hollow Earth'
The Neighborhood Association Council of Wauwatosa has picked two smart, entertaining books for its All-City Read program: Homer H. Hickam Jr.'s memoir "Rocket Boys," and the fantasy novel "Hollow Earth" by Tosa resident Carole E. Barrowman and her actor brother John.
While "Rocket Boys" was the pick for adult readers (13 and older) and "Hollow Earth" for middle-schoolers, skilled younger readers can also appreciate Hickam's book, and many adults would also enjoy the Barrowman siblings' novel. »Read Full Blog Post
Muses inspire Milwaukee Ballet murals
Special Note: This is the first in a series of posts from artist and Art City contributor Stacey Williams-Ng who is working on a series of murals for the Milwaukee Ballet. The "Painting the Muses" series will take us inside the process of one working artist. In this case, Stacey is working on a complex project for the public, from people on the street to young, leaping ballerinas. We will post them on Monday mornings.
Blind Boys of Alabama, David Cook, Trombone Shorty playing Milwaukee shows
A top trombonist, an "American Idol" champion and a decades-old gospel institution are all performing in Milwaukee in November, a spokesman for the Pabst Theater group said.
The Blind Boys of Alabama, with origins dating back to the late 1930s, will perform at the Pabst Theater Nov. 8. »Read Full Article
On Tap for Today: Jealous sorcerer, Brewers and Cubs and movies
Hello, Monday. What's the hurry?
Here's what's on the agenda for today. »Read Full Blog Post(1)


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Solutions for Chapter 29.P
A linear program is generally a maximization or minimization problem and there can be either equations or the inequalities for the constraints.
Various algorithms are there for solving the linear programs, among them the most standard algorithm is the SIMPLEX algorithm. It generally has a fast running time. There is also algorithm whose running time is in polynomial, as ELLIPSOID algorithm. It is slower in practice.
Here to show that the algorithm for linear program can be used to solve the linear inequalities feasibility problem; consider the ELLIPSOID algorithm, it can be used to solve the feasibility problem. The notion is to have a big ellipse, that is the ellipse in the higher dimension. It must lie in the feasible region. Then we will test that the ellipse violates any constraint or not.
If there is no violation then the work is done. But if there is violation then look for it.
So in this way it is possible to know that the solution lies in the ellipse. And this step is repeated to create a smaller ellipse and so on. It has an advantage that you only have to show that the current solution violates the constraints or not.
So, if there is an algorithm for linear program, it can be used to solve the Linear Inequality Feasibility Problem.
In this problem to show that there is an algorithm for linear inequality feasibility problem it is possible to use it to solve the linear program. For this, consider an example in which we have the inequalities procedure and on the basis of that the linear program is formulated,
Consider the example of maximum flow problem for this,
Network flow model: In which it is to be determined the maximum flow from the network.
Inequality constraints:
1. For the edge set a variable and consider only the positive flow in order to have the fewer constraints.
Linear program:
The objective is to find out the maximum possible flow through the edges of the flow network.
That is the objective function, given by:
(The flow into the t is maximized minus any flow out from the t)
Constraints: (Below mention point 2. and 3. are constraints)
2. For all of the edges there is
(Capacity constraints)
3. For all of the vertices there is:
(Conservation constraints)


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Quake III: Team Arena
Never before have the forces aligned. United by name and by cause, The Fallen, Pagans, Crusaders, Intruders, and Stroggs must channel their power into an allied operation where teamwork is the only method of mass destruction. Four distinct games test each troop's synthesis and strength to exacting degrees. Cooperation is the only course of action, and war, the only alternative. Soldiers once alone in their struggle, now face the Arena as one. As cool as it sounds, this expansion for Quake III: Arena was just too little, too late. Sure, the outdoor environments were cool, but whatever.
More Shooter Games


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Primary -L rimary care practitioners are being challenged to provide preventive and curative services to adolescents. Adolescent health services are ideally provided by physicians knowledgeable about normal adolescent growth and development, the practice of adolescent medicine, and the causes of major morbidity and mortality in this age group.1
Under the influence of hypothalamic, pituitary, adrenal, and gonadal hormones, physical growth during adolescence is dramatic.2 Psychological development during adolescence is equally dramatic. Early adolescents (10 to 14 years of age) are focused on the present, in marked contrast to late adolescents (17 to 20 years of age), who usually have attained the cognitive capacity to think ahead about their personal, sexual, and vocational identities. Middle adolescents (14 to 17 years old) are in transition between the stages of early and late adolescence and usually present the greatest challenge because of their struggle with independence, autonomy, and identity.3
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After the seven years of haggling between 108 countries known as the Uruguay Round of the General Agreement on Tariffs and Trade, a final accord has been reached on the liberalization of global trade, which cannot fail to affect the food sector. The agreement represents a major breakthrough in the dismantling of protection for agricultural production worldwide. It provides a framework for the long-term reform of agricultural trade and domestic farm policies over the years to come. The ...
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More minions? 'Despicable Me 2' says yes — fortunately
After witnessing Gru transform from a super-villain to a super-dad with a Play-Doh heart at the end of 2010's "Despicable Me," there was just no way there wouldn't be a sequel.
And "Despicable Me 2," which opens in theaters Wednesday, is better than the original — but not for its storytelling. The 98-minute movie replaces things like plot details with what the audience is clearly more interested in seeing: minions, adorable daddy-daughter moments (Gru, voiced by Steve Carell, dressing up as a "Gruzinklebell" princess for Agnes' birthday) — and of course, for Gru to find the girls a mommy. »Read Full Article
Full Belly Fall Fest in Third Ward will raise money for culinary scholarships
Guests can sample fare from restaurants and take part in a silent auction from 5 to 9 p.m. Sept. 23 at the Full Belly Fall Fest in the Third Ward, all to raise money for culinary scholarships.
The annual event, sponsored by the American Culinary Federation Chefs of Milwaukee, moves this year to the Italian Community Center, 631 E. Chicago St. »Read Full Blog Post
Off the Wall Theatre delivers must-see 'Grey Gardens'
Midway through the first act of the superb "Grey Gardens" now on stage at Off the Wall Theatre, young Edie tries to declare independence from Big Edie, her overbearing mother. It's Little Edie's engagement party, but Big Edie is intent on hogging the spotlight with a recital of favorite songs.
When Little Edie puts her foot down and says "no," Niffer Clarke's Big Edie oozes devastated diva. But Alexandra Bonesho's eager-to-please Little Edie makes clear that the guilt-ridden daughter has it worse. She anxiously tries coaxing Big Edie out of her funk by beginning "Two Peas in a Pod," a loving duet that embodies everything the two women share. »Read Full Article
Panic! At the Disco takes the Rave on a wild, Vegas-y ride
When Panic! at the Disco played the Rave on Friday night, frontman Brendon Urie might not have been trying to represent his hometown of Las Vegas.
However, his showmanship was clearly inspired by the place. »Read Full Article
Performing Arts Events
Barnes & Noble Brookfield Mall: Donald L. Ensenbach "Kokopelli: Dream Catchers of an Ancient," noon-4 p.m. Sept. 20, 95 N. Moorland Road, Brookfield, (262) 796-8550. »Read Full Article
Re-purposed fashion; Doors Open Milwaukee; Apple Harvest Festival
Re-purposeful fashion
The challenge was to create a a garment made of used ... something, anything. Oh, and it had to relate to the theme: environment and water. The results will hit the runway Friday for Redline Milwaukee 2013 Fusion fashion show. Along with a close-up look at the creative costumes, attendees will see a new clothing line developed by four area designers. The show will be 7 p.m. at Redline Milwaukee, 1422 N. 4th St. A cash bar and complimentary treats will be served. Tickets are $25 or $50 and can be purchased at redline-fusion.eventbrite.com. »Read Full Article
Stellar Spark New Year's Eve party bringing 50-plus DJs to the Rave
If you want to dance away the final hours of 2013, the annual Stellar Spark New Year's Eve bash at the Rave will have options for you--more than 50 of them.
DJs will be performing in all five public rooms at the Rave on Dec. 31 for the 11th annual event, led by headliner Adventure Club. Other confirmed acts include Zomboy, Candyland and the Devil from Acapulco. »Read Full Article


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Devil May Cry HD Collection cuts its way onto consoles
Capcom has released a reminder for those not too pleased about Ninja Theory's Devil May Cry reboot of how the swarthy white-haired demon hunter made his name originally.
PS3 and Xbox 360 gamers now have their chance to get their hands on the first three titles in the Devil May Cry series remastered in HD all in one bundle.
The Devil May Cry HD Collection includes an updated control scheme for Devil May Cry 2 as well as all the Dante's Awakening Special Edition extra content for Devil May Cry 3.
This includes Lucia as a playable character in DMC 2 and Dante's twin brother Vergil in DMC 3 plus the Turbo Mode and Bloody Palace Mode for DMC 3.
Latest News
- Call of Duty: Black Ops III is coming to the PS3 and Xbox 360 after all
- Tomonobu Itagaki's Devil's Third gets a release date
- Adr1ft is coming to PC and consoles at the end of the summer
- EA gives the new Mirror's Edge a name – Mirror's Edge Catalyst
- ZombiU PS4 and Xbox One port reportedly in the works
- Mike Bithell's Volume to be released this August
- Gearbox's new shooter Battleborn gets a pre-E3 trailer
- Steam Controller launches in October, Steam Machines arrive in November
- Gears Of War devs Black Tusk change their name to The Coalition ahead of E3


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Most Cited Advanced Drug Delivery Reviews Articles
The most cited articles published since 2011, extracted from Scopus.
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effectJun Fang | Hideaki Nakamura | Hiroshi Maeda
Volume 63, Issue 3, March 2011, Pages 136-151
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues. For example, angiogenesis leads to high vascular density in solid tumors, large gaps exist between endothelial cells in tumor blood vessels, and tumor tissues show selective extravasation and retention of macromolecular drugs. This EPR effect served as a basis for development of macromolecular anticancer therapy. We demonstrated methods to enhance this effect artificially in clinical settings. Of great importance was increasing systolic blood pressure via slow angiotensin II infusion. Another strategy involved utilization of NO-releasing agents such as topical nitroglycerin, which releases nitrite. Nitrite is converted to NO more selectively in the tumor tissues, which leads to a significantly increased EPR effect and enhanced antitumor drug effects as well. This review discusses molecular mechanisms of factors related to the EPR effect, the unique anatomy of tumor vessels, limitations and techniques to avoid such limitations, augmenting tumor drug delivery, and experimental and clinical findings. © 2010 Elsevier B.V.
Liposomal drug delivery systems: From concept to clinical applicationsTheresa M. Allen | Pieter R. Cullis
Volume 65, Issue 1, January 2013, Pages 36-48
The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes, liposomes containing nucleic acid polymers, ligand-targeted liposomes and liposomes containing combinations of drugs. These advances have led to numerous clinical trials in such diverse areas as the delivery of anti-cancer, anti-fungal and antibiotic drugs, the delivery of gene medicines, and the delivery of anesthetics and anti-inflammatory drugs. A number of liposomes (lipidic nanoparticles) are on the market, and many more are in the pipeline. Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance. We can look forward to many more clinical products in the future. © 2012 Elsevier B.V.
Tumor delivery of macromolecular drugs based on the EPR effectVladimir Torchilin
Volume 63, Issue 3, March 2011, Pages 131-135
Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors. © 2010 Elsevier B.V.
Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapyMorteza Mahmoudi | Shilpa Sant | Ben Wang | Sophie Laurent | Tapas Sen
Volume 63, Issues 1-2, January 2011, Pages 24-46
At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described. © 2010 Elsevier B.V.
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug deliveryChalla S S R Kumar | Faruq Mohammad
Volume 63, Issue 9, August 2011, Pages 789-808
Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term "hyperthermia" in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term "hyperthermia" by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled drug delivery through bond breaking (DBB) and hyperthermia-based controlled drug delivery through enhanced permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms -towards successful application in personalized medicine. © 2011 Elsevier B.V.
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivoHiroshi Maeda | Hideaki Nakamura | Jun Fang
Volume 65, Issue 1, January 2013, Pages 71-79
The EPR effect results from the extravasation of macromolecules or nanoparticles through tumor blood vessels. We here provide a historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue. In addition, architectural and physiological differences of tumor blood vessels vs that of normal tissue are commented. Furthermore, methods of augmentation of the EPR effect are described, that result in better tumor delivery and improved therapeutic effect, where nitroglycerin, angiotensin I-converting enzyme (ACE) inhibitor, or angiotensin II-induced hypertension are employed. Consequently, better therapeutic effect and reduced systemic toxicity are generally observed. Obviously, the EPR effect based delivery of nanoprobes are also useful for tumor-selective imaging agents with using fluorescent or radio nuclei in nanoprobes. We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas the EPR effect of nanoparticles involves a prolonged retention time-days to weeks. © 2012 Elsevier B.V.
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biologyNicolas Bertrand | Jun Wu | Xiaoyang Xu | Nazila Kamaly | Omid C. Farokhzad
Volume 66, Issue , January 2014, Pages 2-25
Cancer nanotherapeutics are progressing at a steady rate; research and development in the field has experienced an exponential growth since early 2000's. The path to the commercialization of oncology drugs is long and carries significant risk; however, there is considerable excitement that nanoparticle technologies may contribute to the success of cancer drug development. The pace at which pharmaceutical companies have formed partnerships to use proprietary nanoparticle technologies has considerably accelerated. It is now recognized that by enhancing the efficacy and/or tolerability of new drug candidates, nanotechnology can meaningfully contribute to create differentiated products and improve clinical outcome. This review describes the lessons learned since the commercialization of the first-generation nanomedicines including DOXIL® and Abraxane®. It explores our current understanding of targeted and non-targeted nanoparticles that are under various stages of development, including BIND-014 and MM-398. It highlights the opportunities and challenges faced by nanomedicines in contemporary oncology, where personalized medicine is increasingly the mainstay of cancer therapy. We revisit the fundamental concepts of enhanced permeability and retention effect (EPR) and explore the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages. The overall objective of this review is to enhance our understanding in the design and development of therapeutic nanoparticles for treatment of cancers. © 2013 Elsevier B.V.
Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applicationsEmanuel Fleige | Mohiuddin A. Quadir | Rainer Haag
Volume 64, Issue 9, June 2012, Pages 866-884
The use of polymeric nanocarriers to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Not only that these nanocarriers enhance the properties of already existing drugs in terms of solubility, bioavailability, and prolonged circulation times, furthermore they can be tailor-made in such a manner that they selectively release their cargo at the desired site of action. For the triggered release, these so-called smart drug delivery systems are designed to react on certain stimuli like pH, temperature, redox potential, enzymes, light, and ultrasound. Some of these stimuli are naturally occurring in vivo, for example the difference in pH in different cellular compartments while others are caused by the disease, which is to be treated, like differences in pH and temperature in some tumor tissues. Other external applied stimuli, like light and ultrasound, allow the temporal and spatial control of the release, since they are not triggered by any biological event. This review gives a brief overview about some types of stimuli-responsive nanocarriers with the main focus on organic polymer-based systems. Furthermore, the different stimuli and the design of corresponding responsive nanocarriers will be discussed with the help of selected examples from the literature. © 2012 Elsevier B.V.
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effectSarbari Acharya | Sanjeeb K. Sahoo
Volume 63, Issue 3, March 2011, Pages 170-183
As mortality due to cancer continues to rise, advances in nanotechnology have significantly become an effective approach for achieving efficient drug targeting to tumour tissues by circumventing all the shortcomings of conventional chemotherapy. During the past decade, the importance of polymeric drug-delivery systems in oncology has grown exponentially. In this context, poly(lactic- co-glycolic acid) (PLGA) is a widely used polymer for fabricating 'nanoparticles' because of biocompatibility, long-standing track record in biomedical applications and well-documented utility for sustained drug release, and hence has been the centre of focus for developing drug-loaded nanoparticles for cancer therapy. Such PLGA nanoparticles have also been used to develop proteins and peptides for nanomedicine, and nanovaccines, as well as a nanoparticle-based drug- and gene-delivery system for cancer therapy, and nanoantigens and growth factors. These drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect. Ongoing research about drug-loaded nanoparticles and their delivery by the EPR effect to the tumour tissues has been elucidated in this review with clarity. © 2010 Elsevier B.V.
Hydrogels for biomedical applicationsAllan S. Hoffman
Volume 64, Issue SUPPL., December 2012, Pages 18-23
This article reviews the composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices. The most important properties of hydrogels relevant to their biomedical applications are also identified, especially for use of hydrogels as drug and cell carriers, and as tissue engineering matrices. © 2012 Elsevier B.V.
Stimuli-responsive LbL capsules and nanoshells for drug deliveryMihaela Delcea | Helmuth Möhwald | André G. Skirtach
Volume 63, Issue 9, August 2011, Pages 730-747
Review of basic principles and recent developments in the area of stimuli responsive polymeric capsules and nanoshells formed via layer-by-layer (LbL) is presented. The most essential attributes of the LbL approach are multifunctionality and responsiveness to a multitude of stimuli. The stimuli can be logically divided into three categories: physical (light, electric, magnetic, ultrasound, mechanical, and temperature), chemical (pH, ionic strength, solvent, and electrochemical) and biological (enzymes and receptors). Using these stimuli, numerous functionalities of nanoshells have been demonstrated: encapsulation, release including that inside living cells or in tissue, sensors, enzymatic reactions, enhancement of mechanical properties, and fusion. This review describes mechanisms and basic principles of stimuli effects, describes progress in the area, and gives an outlook on emerging trends such as theranostics and nanomedicine. © 2011 Elsevier B.V.
Vascularization is the key challenge in tissue engineeringEsther C. Novosel | Claudia Kleinhans | Petra J. Kluger
Volume 63, Issue 4, April 2011, Pages 300-311
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system - the vascularization. In vivo almost all tissues are supplied by these endothelial cell coated tubular networks. Current strategies to create vascularized tissues are discussed in this review. The first strategy is based on the endothelial cells and their ability to form new vessels known as neoangiogenesis. Herein prevascularization techniques are compared to approaches in which biomolecules, such as growth factors, cytokines, peptides and proteins as well as cells are applied to generate new vessels. The second strategy is focused on scaffold-based techniques. Naturally-derived scaffolds, which contain vessels, are distinguished from synthetically manufactured matrices. Advantages and pitfalls of the approaches to create vascularized tissues in vitro are outlined and feasible future strategies are discussed. © 2010 Elsevier B.V.
Environment-sensitive hydrogels for drug deliveryYong Qiu | Kinam Park
Volume 64, Issue SUPPL., December 2012, Pages 49-60
Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. Light-sensitive, pressure-responsive and electro-sensitive hydrogels also have the potential to be used in drug delivery and bioseparation. While the concepts of these environment-sensitive hydrogels are sound, the practical applications require significant improvements in the hydrogel properties. The most significant weakness of all these external stimuli-sensitive hydrogels is that their response time is too slow. Thus, fast-acting hydrogels are necessary, and the easiest way of achieving that goal is to make thinner and smaller hydrogels. This usually makes the hydrogel systems too fragile and they do not have mechanical strength necessary in many applications. Environmentally sensitive hydrogels for drug delivery applications also require biocompatibility. Synthesis of new polymers and crosslinkers with more biocompatibility and better biodegradability would be essential for successful applications. Development of environmentally sensitive hydrogels with such properties is a formidable challenge. If the achievements of the past can be extrapolated into the future, however, it is highly likely that responsive hydrogels with a wide array of desirable properties can be made. © 2012 Elsevier B.V.
Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactionsAlaaldin M. Alkilany | Lucas B. Thompson | Stefano P. Boulos | Patrick N. Sisco | Catherine J. Murphy
Volume 64, Issue 2, February 2012, Pages 190-199
Gold nanorods have promising applications in the fields of drug delivery and photothermal therapy. These promises arise from the nanorods' unique optical and photothermal properties, the availability of synthetic protocols that can tune the size and shape of the particles, the ability to modify the surface and conjugate drugs/molecules to the nanorods, and the relative biocompatibility of gold nanorods. In this review, current progress in using gold nanorods as phototherapeutic agents and as drug delivery vehicles is summarized. Issues of dosage, toxicity and biological interactions at three levels (biological media alone; cells; whole organisms) are discussed, concluding with recommendations for future work in this area. © 2011 Elsevier B.V.
Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriersLaura M. Ensign | Richard Cone | Justin Hanes
Volume 64, Issue 6, May 2012, Pages 557-570
Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous hurdles, including the acidic gastric environment and the continuous secretion of mucus that protects the GI tract. Nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GI tract may enable more efficient and sustained drug delivery. However, the rapid secretion and shedding of GI tract mucus can significantly limit the effectiveness of nanoparticle drug delivery systems. Many types of nanoparticles are efficiently trapped in and rapidly removed by mucus, making controlled release in the GI tract difficult. This review addresses the protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier. © 2011 Elsevier B.V.
Nanoparticle and targeted systems for cancer therapyLisa Brannon-Peppas | James O. Blanchette
Volume 64, Issue SUPPL., December 2012, Pages 206-212
This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery. These areas include delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting. Treatment opportunities using antibody-targeted therapies are summarized. The ability to treat cancer by targeting delivery through angiogenesis is also discussed and antiangiogenic drugs in clinical trials are presented. Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers. © 2012.
Microneedles for drug and vaccine deliveryYeu Chun Kim | Jung Hwan Park | Mark R. Prausnitz
Volume 64, Issue 14, November 2012, Pages 1547-1568
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications. © 2012 Elsevier B.V.
A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemmaHiroto Hatakeyama | Hidetaka Akita | Hideyoshi Harashima
Volume 63, Issue 3, March 2011, Pages 152-160
Gene and nucleic acid therapy are expected to play a major role in the next generation of medicine. We recently developed a multifunctional envelope-type nano device (MEND) for use as a novel non-viral gene delivery system. Poly(ethylene glycol) (PEG)ylation is a useful method for achieving a longer circulation time for delivery of the MEND to a tumour via the enhanced permeability and retention (EPR) effect. However, PEGylation strongly inhibits cellular uptake and endosomal escape, which results in significant loss of activity for the delivery system. For successful gene delivery for cancer treatment, the crucial issue associated with the use of PEG, the 'PEG dilemma' must be addressed. In this review, we describe the development and applications of MEND, and discuss strategies for overcoming the PEG dilemma, based on the manipulation of intracellular trafficking of cellular uptake and endosomal release using functional devices such as specific ligands, cleavable PEG systems and endosomal fusogenic/disruptic peptides. © 2010 Elsevier B.V.
Nanoparticles and microparticles for skin drug deliveryTarl W. Prow | Jeffrey E. Grice | Lynlee L. Lin | Rokhaya Faye | Margaret Butler | Wolfgang Becker | Elisabeth M T Wurm | Corinne Yoong | Thomas A. Robertson | H. Peter Soyer | Michael S. Roberts
Volume 63, Issue 6, May 2011, Pages 470-491
Skin is a widely used route of delivery for local and systemic drugs and is potentially a route for their delivery as nanoparticles. The skin provides a natural physical barrier against particle penetration, but there are opportunities to deliver therapeutic nanoparticles, especially in diseased skin and to the openings of hair follicles. Whilst nanoparticle drug delivery has been touted as an enabling technology, its potential in treating local skin and systemic diseases has yet to be realised. Most drug delivery particle technologies are based on lipid carriers, i.e. solid lipid nanoparticles and nanoemulsions of around 300. nm in diameter, which are now considered microparticles. Metal nanoparticles are now recognized for seemingly small drug-like characteristics, i.e. antimicrobial activity and skin cancer prevention. We present our unpublished clinical data on nanoparticle penetration and previously published reports that support the hypothesis that nanoparticles > 10. nm in diameter are unlikely to penetrate through the stratum corneum into viable human skin but will accumulate in the hair follicle openings, especially after massage. However, significant uptake does occur after damage and in certain diseased skin. Current chemistry limits both atom by atom construction of complex particulates and delineating their molecular interactions within biological systems. In this review we discuss the skin as a nanoparticle barrier, recent work in the field of nanoparticle drug delivery to the skin, and future directions currently being explored. © 2011 Elsevier B.V.
Advanced materials and processing for drug delivery: The past and the futureYing Zhang | Hon Fai Chan | Kam W. Leong
Volume 65, Issue 1, January 2013, Pages 104-120
Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Materials innovation and nanotechnology have synergistically fueled the advancement of drug delivery. Innovation in material chemistry allows the generation of biodegradable, biocompatible, environment-responsive, and targeted delivery systems. Nanotechnology enables control over size, shape and multi-functionality of particulate drug delivery systems. In this review, we focus on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug delivery. © 2012 Elsevier B.V.
Physical and chemical stability of drug nanoparticlesLibo Wu | Jian Zhang | Wiwik Watanabe
Volume 63, Issue 6, May 2011, Pages 456-469
As nano-sizing is becoming a more common approach for pharmaceutical product development, researchers are taking advantage of the unique inherent properties of nanoparticles for a wide variety of applications. This article reviews the physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization techniques. A few common strategies to overcome stability issues are also discussed. © 2011.
Nanosizing for oral and parenteral drug delivery: A perspective on formulating poorly-water soluble compounds using wet media milling technologyElaine Merisko-Liversidge | Gary G. Liversidge
Volume 63, Issue 6, May 2011, Pages 427-440
A significant percentage of active pharmaceutical ingredients identified through discovery screening programs is poorly soluble in water. These molecules are often difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues, e.g. poor bioavailability, lack of dose proportionality, slow onset of action and other attributes leading to poor patient compliance. In addition, for parenteral products, these molecules are generally administered with co-solvents and thus have many undesirable side effects. Wet media milling is one of the leading particle size reduction approaches that have been successfully used to formulate these problematic compounds. The approach is a water-based media milling process where micron-sized drug particles are shear-fractured into nanometer-sized particles. Nanoparticle dispersions are stable and typically have a mean diameter of less than 200. nm with 90% of the particles being less than 400. nm. The formulation consists only of water, drug and one or more GRAS excipients. Drug concentrations approaching 300-400. mg/g can be targeted with the use of minimal amounts stabilizer. Typically, on average, the drug to stabilizer ratio on a weight basis ranges from 2:1 to 20:1. These liquid nanodispersions exhibit acceptable shelf-life and can be post-processed into various types of solid dosage forms. Nanoparticulate-based drug products have been shown to improve bioavailability and enhance drug exposure for oral and parenteral dosage forms. Suitable formulations for the most commonly used routes of administration can be identified with milligram quantities of drug substance providing the discovery scientist an alternate avenue for screening and identifying superior leads. In the last few years, formulating poorly water soluble compounds as nanosuspensions has evolved from a conception to a realization. The versatility and applicability of this drug delivery platform are just beginning to be realized. © 2011 Elsevier B.V.
Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effectsKazuo Maruyama
Volume 63, Issue 3, March 2011, Pages 161-169
The success of an effective drug delivery system using liposomes for solid tumor targeting based on EPR effects is highly dependent on both size ranging from 100-200. nm in diameter and prolonged circulation half-life in the blood. A major development was the synthesis of PEG-liposomes with a prolonged circulation time in the blood. Active targeting of immunoliposomes to the solid tumor tissue can be achieved by the Fab' fragment which is better than whole IgG in terms of designing PEG-immunoliposomes with prolonged circulation. For intracellular targeting delivery to solid tumors based on EPR effects, transferrin-PEG-liposomes can stay in blood circulation for a long time and extravasate into the extravascular of tumor tissue by the EPR effect as PEG-liposomes. The extravasated transferrin-PEG-liposomes can maintain anti cancer drugs in interstitial space for a longer period, and deliver them into the cytoplasm of tumor cells via transferrin receptor-mediated endocytosis. Transferrin-PEG-liposomes improve the safety and efficacy of anti cancer drug by both passive targeting by prolonged circulation and active targeting by transferrin. © 2010 Elsevier B.V.
Toxicology of nanoparticlesAndreas Elsaesser | C. Vyvyan Howard
Volume 64, Issue 2, February 2012, Pages 129-137
While nanotechnology and the production of nanoparticles are growing exponentially, research into the toxicological impact and possible hazard of nanoparticles to human health and the environment is still in its infancy. This review aims to give a comprehensive summary of what is known today about nanoparticle toxicology, the mechanisms at the cellular level, entry routes into the body and possible impacts to public health.Proper characterisation of the nanomaterial, as well as understanding processes happening on the nanoparticle surface when in contact with living systems, is crucial to understand possible toxicological effects. Dose as a key parameter is essential in hazard identification and risk assessment of nanotechnologies. Understanding nanoparticle pathways and entry routes into the body requires further research in order to inform policy makers and regulatory bodies about the nanotoxicological potential of certain nanomaterials. © 2011 Elsevier B.V.
Luminescent quantum dots as platforms for probing in vitro and in vivo biological processesHedi Mattoussi | Goutam Palui | Hyon Bin Na
Volume 64, Issue 2, February 2012, Pages 138-166
In this report we review some of the recent progress made for enhancing the biocompatibility of luminescent quantum dots (QDs) and for developing targeted bio-inspired applications centered on live cell imaging and sensing. We start with a detailed analysis of the surface functionalization strategies developed thus far, and discuss their effectiveness for providing long term stability of the quantum dots in biological media, to changes in pH and to added electrolytes. We then discuss the available conjugation techniques to couple QDs to a variety of biological receptors and compare their effectiveness. In particular, we highlight the implementation of new strategies such as the use of copper-free cyclo-addition reaction (CLICK) chemistry and chemo-selective ligation. We then discuss the advances made for intracellular delivery where ideas such as receptor-driven endocytosis and uptake promoted by cell penetrating peptides are used. We then describe a few representative examples where QDs have been used to investigate specific cell biology processes. Such processes include binding of QDs conjugated to the nerve growth factor to membrane specific receptors and intracellular uptake, tracking of membrane protein at the single molecule level, and recognition of ligand bound QDs by T cell receptors. We conclude by discussing issues of toxicity associated with the use of QDs in biology. © 2011 Elsevier B.V.


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Doctor insights on:
How Can I Prevent A Wobbly Permanent Tooth From Falling Out
How can I prevent a wobbly permanent tooth from falling out?
See a dentist: First question is why is it wobbly, from a bad bite or gum disease. Only a dentist can tell you why and then there might be ways to correct it. ...Read moreSee 1 more doctor answer
Permanent Tooth (Definition)
Primary teeth are also called "baby teeth." these then "fall out" or exfoliate and the seconday tooth or ...Read more
Is there a way to prevent dental bone loss when a child loses a permanent tooth prematurely and cannot get an implant because of young age?
See an ortodontist: There are no enough studies to determine the best method, or the most appropriate materials for bone loss for kids. In many cases orthodontic treatment is recommended to close the space. ...Read moreSee 1 more doctor answer
Can you tell whether a tooth is a baby tooth or permanent tooth, if you don't recall it falling out?
Yes: You can tell because baby teeth look different than adult teeth. They are usually smaller versions of the adult tooth. If you still are not sure, visit your dentist and he or she can tell by looking at it or taking an xray. There you can also find out what happened to the adult tooth. ...Read moreSee 1 more doctor answer
Got a permanent tooth extracted and never got an impact so the teeth close by are falling into that place. Well invisalign correct this?
Depends: Posterior Bite Collapse. If teeth on either side of space have collapsed Invisalign can improve space by up to about 66%. If teeth in opposing arch have over-erupted, Invisalign not very effective at intrusion. Please see an orthodontic Specialist before this gets worse. ...Read moreSee 2 more doctor answers
What do you do if a permanent tooth falls out?
Get an Xray: See your dentist and get an xray of the site to make sure there are no pieces of the tooth under the gums. The dentist can give you options after he examines the area and surrounding bone. You have many options. A few are , do nothing, place an implant or bridge, build a removable prosthetic to replace the tooth, or move another tooth into the space with orthodontics. ...Read moreSee 1 more doctor answer
How long does it take for his permanent tooth to come in after his baby tooth falls out?
Just depends: Some teeth come in before the baby tooth falls out and others can take a month. You should see a dentist to make sure the adult tooth is there and is erupting properly. ...Read moreSee 2 more doctor answers
One of my permanent tooth is loose and wobbly, what can I do?
Call ur dentist: Wobbly, loose teeth can indicate periodontal problems. Can't tell if that is what ails you. But a local dentist in virginia beach can. Please call for a consult. ...Read moreSee 1 more doctor answer
6 year old has wobbly permanent tooth after shark baby tooth fell out. He's had no injuries to the permanent tooth but is slightly wobbly. Worried?
See a pedodontist: a dentist who specializes in the care of children's teeth. ...Read moreSee 2 more doctor answers
Are space maintainers removed as soon as the permanent tooth starts erupting? Our son needs to have a space maintainer put in after having a baby tooth knocked out, and i'd like to know at what point they are generally removed.
Yes: Generally they are removed when the tooth they are holding space for erupts. There are times when the maintainer is left for other orthodontic purposes. Not every missing tooth needs a space maintainer. Generally if the tooth missing is one of the front 4 a space maintainer is not indicated. ...Read moreSee 2 more doctor answers
Can a chipped baby tooth later affect how a permanent tooth comes in? Our four year old daughter tripped and fell, chipping a front tooth pretty badly. She has a dentist appointment in two days, but we're concerned that this might later cause problems for
1 more thing: In addition to dr aronowitz' thorough answer, know that damage to a baby tooth can cause damage or displacement to the underlying permanent tooth. If the 2 upper front permanent teeth do not erupt within a month or two of each other, about age 6-7, see an orthodontist to evaluate growth and development. ...Read moreSee 2 more doctor answers
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5 things you won't believe are only built with CSS
Trevan Hetzel breaks down 5 UI interactions typically built with JavaScript, implemented only with CSS. By Trevan Hetzel I often find myself amazed at what plain 'ol CSS can do. People float things with CSS, they clear things, they color things, they make things fancy. But there are a lot more hidden, or I should […]
Ordering CSS for Everyone
By Scott O'Hara I often find myself getting into discussions, or arguments disguised as discussions, about the preferred ordering methods for CSS properties. Yeah. That's how I party. Anyway, it basically boils down to three different methods that you could follow: Random Ordering (because you hate yourself and others) Ordering via Property Groupings Alphabetically – […]
Animating Inline SVG Icons
By Joni Trythall I recently did some experimenting with animating inline SVG icons. In this article I will quickly review my process and discuss the joys and frustrations I ran into. The demo discussed in the article is below and works on Chrome only for the moment. Scroll down to view all the icons and […]
Dynamic CSS with DynCSS
Organizing Your CSS Code for Preprocessors
By Tim Severien CSS preprocessors are probably one of the most useful things we have right now in front-end tooling. Whether you pick Sass, LESS or any other preprocessor, they're great because they add so many features CSS never had. But I'm not trying to convince you use preprocessors, I assume you already do. Instead, […]
Doing More with Sass' @each Control Directive
By Scott O'Hara I recently wrote an article about the different Sass control directives and how even writing basic directives could be used to code leaner Sass. In this article, I'd like to take a closer look at the @each directive, Sass variable lists and maps. Combining these features can make for some powerful results […]
Creating Modular View Components with React and Grunt
By Simon Smith One of the libraries gaining a lot of interest recently is Facebook's React JS library. It mainly concerns itself with "the V in MVC" and encourages developers to break their app into resuable, modular components. The Virtual DOM is a great feature on its own, and I encourage you to investigate React […]
Getting into Sass Control Directives
By Scott O'Hara Sass makes it very easy to use mixins and extends to write leaner CSS. But perhaps you're not familiar with how Sass's Control Directives can help you write leaner Sass. Using the @if, @for, @each and @while control directives, you can make your Sass take on the brunt of what would otherwise […]
Grids in CSS3
By Tim Severien In this article, we'll take a look at some of the new features in CSS3 that make handling grids using HTML and CSS much easier. But first let's discuss a little history of grids in HTML and CSS to get an understanding of what made them difficult. A Short History of Grids […]
CSS for Beginners with Dreamweaver
By Brian Rinaldi Dreamweaver has had a long history. I recall using it heavily back in the UltraDev days, for those of you that remember that. While the tool has evolved quite a lot over the years, it remains a powerful web development IDE. Sure, everyone seems to love a lightweight code editor nowadays for […]
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Fall is for planting. The light is still strong and the temperatures mild. It's an ideal time for settling in many plants because they can establish a good root system before dealing with ... more »
Many plants put on their best show in the fall. Why not add one to your garden. Below are some of my favorites that are easy to find in garden centers right now ... more »
Urban gardening and sustainable gardening are "hot" right now. But some people have been practicing both for decades. On the west side of Chicago lives one such pioneer. Carl Walton planted his garden ... more »
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I need someone to blog about my jewellery website and the quality of my products.
Must have exceptional english and the reviews must make sense and be in context with the blog or site that the review is submitted on. Each review must be differently worded as not to be classified as spam. I need the reviews to sound like they are coming from actual customers, not someone who is being paid to review the site :-D
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Environmental Management Companies in Ghana
Current filtering criteriaYou can remove a filter by clicking on the x
MacBens Multi Resources Limited
based in Accra , GHANA
MacBens Multi Resources limited, a company of safety, health, environment & quality consultants and trainers registered in Ghana. At MacBens (Training & Consultancy Division), we provide training and consultancy services to our clients throughout Ghana and beyond through partnerships on occupational safety, health, environment & quality management issues. Trainings ...
based in Accra, GHANA
We have become a force to reckon with; the Rolls Royce in the water industry. There could never be clean, safe and chilled drinking water anywhere without WaterSmile behind. Having worked with the world`s no. 1 brands, Oasis, Danon, Eden, Family, Aquacool, etc.We are the name when it comes to drinking water fountains (for schools, churches, hospitals, factories gardens, ...
WaterHealth International
Office in Accra, GHANA
WaterHealth International is a unique and creative combination of break-through technology and innovative business models enables the delivery of highly affordable, clean water to even the most remote, low-income rural communities. Led by a team of international experts in science, technology, business and health, WaterHealth is redefining the way potable water is ...
Amandi Ltd
based in Accra, GHANA
Amandi has been successfully delivering large-scale construction projects in Ghana for over a decade. From our base in Accra, we provide technically advanced civil and marine engineering solutions for a range of commercial and government clients. We are committed to the economic and social growth of Ghana through the use of engineering excellence and modern construction ...
AST Clean Water Technologies
Distributor in Accra, GHANA
AST is an Israeli company specializing in smart water treatment solutions. AST focus on the development, design, and manufacture of large variety of water and waste water treatment Filtration solution and membrane systems capitalizing on its strategic partners like Porex USA, VSEP INC , Trisep , INGE GMBH Germany – and other Suppliers of products and membrane. Our ...
Geotech Ltd.
Office in Adjiringanor, East Legion, Acc, GHANA
Geotech Ltd. is a mining, energy, engineering and environmental services company providing airborne geophysical survey services and instrumentation worldwide. From fixed-wing and helicopter geophysical platforms Geotech provides sub-surface analysis of lithology for site characterization, mapping water resources, mapping soil types and changes for agricultural and ...
Trana-Tek Ghana Limited
based in Accra, GHANA
Trana-Tek Ghana Limited is a full service company providing Surveying, Engineering and Logistics services to the Mining, Exploration, Drilling, Oil and Gas industries in Ghana and the West African Sub region. Our expertise in Surveying ranges from Directional Downhole surveying, Geophysical Surveying , Engineering Surveying, Topographical Surveying , Hydrographical ...
Namene Energy Limited
Office in Accra, GHANA
Namene Energy Limited is a developer of renewable energy solutions with a primary market in Africa. Namene Energy is active in the solar pv market in Togo (Namene Energy Togo SARL) and Ghana (SolarGen Ghana Limited).Namene Energy Limited's core business is in project development and financing. It elaborates turnkey investment programs (from site location to obtaining ...
Interra - Environmental Management Consultants
based in Accra, GHANA
Interra is a leading provider of Environmental, Health, Safety, Risk and Social Consulting Services. With sustainability at the heart of both our services and how we do business, we are committed to providing a service that is consistently of the highest quality. Interra is built on the unique skills, experience and resourcefulness of its dedicated professionals to offer ...
based in Takoradi, GHANA
Since its beginnings, Dynamik Equipment endeavours to meet the needs for its customers working around the world by proposing performant products as well as a personalized technical support. We now continue our efforts of research and development in order to offer to our customers in ever increasing number an improved range of innovating products and services, thus ...
Greenfields Energy Services
based in Takoradi, GHANA
Greenfields Energy is emerging as a leading provider and supplier of engineered solutions to the oil and gas, and marine and renewable offshore industries. Headquartered in Takoradi Western Ghana, Greenfields Energy presence spans operational centres located in Ghana and other oil producing West Africa countries, We also have Technical Affiliates in the UK. Formed in ...
based in GHANA
Earthtech Ingineers is a Ghana based Geoscience Service and Resource Development Company, of able professionals.The company provides a comprehensive range of Geological/Geotechnical including Geophysics and Seismology, (Field Exploration including Mapping, Sampling, Laboratory Testing, Analysis and Reporting), Earthworks construction Quality Control Services, ...
Global Trackers & Car Alarms Ltd
based in Accra, GHANA
The best vehicle tracking company in Ghana.GTL is a leading global provider of GPS Tracking/fleet management solutions for individuals, small and medium & large-sized businesses delivered as software-as-a-service (SaaS). We are partners to Insurance Companies who offer 'pay-as-you-drive' or behavioural insurance products. We are the only company having the DUAL SIM ...
Grenotek Energy and Environmental Services
based in GHANA
Grenotek Energy and Environmental Service is a new dimensional environmental company in Ghana established with the focus on provision of renewable energy products and environmental remediation services in Ghana.Grenotek is a partner to many environmental and energy companies in chinaGrenotek aims to provide Ghanaian communities with affordable renewable energy solutions ...
based in ACCRA, GHANA
Greenteam Ghana Limited was established i in 2011 to provide comprehensive consultancy services in the area of environmental impact assessment specifically in the Contraction, Agriculture and the Oil and Gas industries.Our main focus is to promote sustainable development through creativity and innovations.Greenteam aim to bring competent environmental expertise to bear ...
EnvironQuest Nigeria Limited
Office in GHANA
EnvironQuest provides integrated environmental and natural resource management services to address environmental issues and risks associated with your business. We assist you with prompt, qualitative and scientifically-sound services, which improve your environmental performance within overall business objective.
Gast International
Office in GHANA
Gast provides a complete spectrum of services from design and supply to installation in both the civil and construction industries. The Group's philosophy is based on the principle of single point responsibility. Having successfully completed more than 9150 projects during the last millennium, Gast boast accreditation from United Nations and World Bank, giving credit to ...
Kamsak Ltd
based in Nsawam, GHANA
Our Mission:The Mission of Kamsak Ltd is to supply and exceed the clients expectation by provision of quality products and value for money whilse establishing a successful relationship with our clients.Our Vision:The vision of Kamsak Ltd is to become the Leading manufacturer and supplier of both mining and industrial chemicals especially SODIUM CYANIDE, CAUSTIC SODA and ...
Tremis Company Limited
based in Accra, GHANA
remis was first established in Finland to meet a growing demand for remote monitoring equipment focused on security and safety. We provide a comprehensive range of products and services for homes and companies for remote monitoring and controlling their resources. Our solutions combine measurement technology, data handling solutions, control and innovative reporting ...
Eastwind Harlley Limited
based in Achimota Accra, GHANA
Eastwind Harlley Limited
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straight pull sa80?
Tools and Technologies
Rifle Country
> straight pull sa80?
February 28, 2010, 08:26 AM
already got a stryr aug for foxing now looking for something to put a NV scope on so im wondering if any of you boys have experience with one of these
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February 28, 2010, 09:46 AM
Oh hoho, the SA80 is a very, very rare kitten indeed. I think you would be better off trying to get one of your L98 Cadet Rifles. AFAIK, the only SA80 in 'production' is the Prexis PL-85, and that is definitely not legal in England, not to mention you have to bend the lower yourself.
February 28, 2010, 03:05 PM
I would think that the reliability issues of the SA-80, and the general embarrassment it caused your countries ordnance department after adopting it would preclude it's choice as a relied upon rifle. Do you have any links to the one you are talking about?
I am assuming that by straight pull, you mean it is not a semiautomatic rifle, that it resembles one, and you have to manually operate the charging handle each time to cycle the action.
Kinda Ironic that it took the Germans to sort out the problems out with that gun.
February 28, 2010, 03:21 PM
i can only get straight pull no semi autos and dont feel like another steyr there is afew ex cadet rifles and about or i was thinking about a ruger mini 14 that i could modify to bullpup but i like the sa80`s more
February 28, 2010, 04:03 PM
I was in the Army Cadets and used those rifles (The L98A1 Cadet GP and the L86A1 LSW). Were you also a Cadet?
If you were, and wish to buy something that you are familiar with, that's fair enough.
Personally, I can only think of a few reasons to buy it:
The good:
Novelty value
The 5.56 NATO round is nice to shoot in it
High ammo capacity
It uses NATO 5.56 magazines (plenty of them in the world)
Is pretty darn accurate
Easy to field strip - I did it blindfolded (L98A1) - never was good at cleaning it though
The bad
Heavy - about as heavy as an M1 Garand (no, really)
Cocking the weapon is comparatively awkward (remember this is something you will be doing for each shot)
Not all that comfortable in the prone position IMO
Probably going to be expensive
March 1, 2010, 11:32 AM
iv used a mates and he had a modded bolt handle and barrel and i found it very easy to use and i like bullpups for nights shooting as my other guns are big and when your climbing over fences with a full size 223 it proberly isnt safe.
i no that with there not being many about resale value will proberly be good aswell
March 1, 2010, 05:22 PM
Seems to me that if I were planning on using it as a working gun, I would go with a bolt action instead. The ergonomics, price, accuracy, trigger and other things are all going to be better with a good bolt gun. If you're looking for a collectible and fun shooter first that can also perhaps work for hunting, then I might go for the SA80. They have an excellent reputation for accuracy and I would imagine that a straight pull action would only improve on that.
March 2, 2010, 11:18 AM
Well hiho, if it 'ticks the right boxes' for your personal use, then by all means go for it! Personally I wouldn't especially go looking for one, as I have had mostly 'meh' (indifferent) memories of it as a Cadet. It fulfils it's role, but doesn't excite me.
I'd want a bolt-action rifle myself. :D
March 2, 2010, 01:43 PM
i would say im getting one as im getting on with my dealer (bought shotgun last week and traded a rifle) and he has one in stock
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One potential drawback for fans of the drink, however, is volume -- the bowtie can holds only 11.3 ounces of beer, as opposed to 12 in the standard version.


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Nichole NordahlShared publicly -
Balance is having the "right things in the proper measure and complementary to everything else."
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What's open on Thanksgiving?
It's November. Do you know where your Thanksgiving dinner will be? No? Well. Restaurants stand ready to help.
Here are some that are open on Thanksgiving — Nov. 22 this year. (Surely there are more; others can add their hours and contact info in the comments if they'd like.) »Read Full Blog Post(2)
Setzer brings swinging holiday cheer to Potawatomi
On the 16th day of November, Brian Setzer gave with glee: 5 sax men, 4 trumpet players, 2 backing singers...and drums dressed in tinsel, glittering.
The Brian Setzer Orchestra's Christmas show, at Potawatomi Bingo Casino's Northern Lights Theater, also had falling suds (subbing for snow), TV theme song cameos (including "The Flintstones," "Peter Gunn" and "The Andy Griffith Show") and covers from Setzer's Stray Cats rockabilly days. »Read Full Article(1)
Danceworks' 'Intersect' showcases breadth of artists involved
If one creative mind is a good thing, bringing many together for a project must be an even better thing — right?
Apparently so, given the variety of dance and original music in the Danceworks Performance Company's collaborative "Intersect" program. »Read Full Article
Next Act Theatre offers solid primer on Marxism with 'Groucho'
Like the Marx Brothers' early vaudeville show, Next Act Theatre's"Groucho: A Life in Revue" is a "skule" act. It gently and congenially educates the audience about one of America's great comedians, Groucho Marx, whose remarkable career included Broadway, movie and TV hits built around his wisecracking persona.
After a brief opening sequence, this revue, written by Groucho's son Arthur and Robert Fisher, unfolds chronologically. It's sentimental in spots, but heck, you might be sentimental, too, if you were writing a show about your father and uncles. It's not warts and all, but it does acknowledge Groucho's regrets about three marriages that ended in divorce. »Read Full Article


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Top Definition
When a girl jerks you and your friend off when your on either side of her, her up and down motions resemble a skier using ski poles
Hey did u guys get a piece or what?
Yeah she ski poled us but nothin else
Yeah she ski poled us but nothin else
додав Bill B 23 Квітня 2003
Trending Now
Can you define these popular missing words?
A nickname given to any girl who has been known to simultaneously jerk off two guys sitting either side of her.
I hope ski poles is coming on our next excursion, Jack.
She sure made the bus trip a highlight last time.
She sure made the bus trip a highlight last time.
додав tweeter27 12 Червня 2006
when a girl beats off two guys in a jerking motion like skiing
You this beat fresman slut named sarah ski poled a couple fags last night, ones a canisus fag
додав Mrs.Newrighter 15 Листопада 2007
Dave Hoagrbe directing traffick
what the hell is he doing directing trafick or jerking someone off?
nah thats just ski poles dave.. he does that all the time
nah thats just ski poles dave.. he does that all the time
додав Hoagrbee 13 Жовтня 2008
riding in the middle of two people in the back or front seat.
dude I can't ride ski pole in the back seat.
додав e nigma99999 26 Березня 2011
synonomous with circle jerk. (pretend that you are cross-country skiing, moving your arms up and down vigorously)
"the yankees suck. how about some ski pole action?"
додав peter 15 Жовтня 2003


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15 years of experience
Accepting new patients
Cleveland Clinic-Weston
2950 Cleveland Clinic Blvd
Weston, FL 33331 Phone number & directions
Patient Reviews
Patient Reviews ? Write a Review
Overall Rating:
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Fabulous doctor. Saved my life and sanity. Diagnosed and treated my bladder cancer. Awesome diagnostician, up to date on all the latest procedures. Most caring, dedicated, physician ever. Loves his patients, job, and learning. They come no finer or better.
We were encouraged by our daughter to get an opinion at U of M and they pretty much confirmed what he told us.
Dr. Hakim was a real hack. He inspired no confidence in me before his surgery and screwed me up terribly. I'm so sorry I ever seen that man I'll never go back
Spent a lot of time with us during visit. Did give us choices (almost too many). We eventually choose surgery and it went well. Genuinely seems to care.
I have had 2 bladder cancer operations and need to be "scoped" which I havent had done in a year because of no medical insurance. I am on disability and cannot afford the co-pay of 600 from my spin down medicaid . i explain it to the nurse that i needed the procedure done within this month. she scheduled me and when they called to remind me the day before she says " o this is only a consultation visit I was furious and cancelled, why so he can get more money??? im gonna die now from cancer and they dont give a dam. i am getting another procedure done this month and would have only 600 dollars to pay for both procedures now i cant afford and lord knows when i will save the money up again. hypocratic oath?? I think not more like greed and money and hypocritic oath. the only guy for miles and im screwed
Unable to diagnose source of blood and atypical cells in urine after doing biopsy and uroscopy. Suggested I "come back if I had anymore problems." When asked to make referral to U of M, it took him two weeks to do it. He is very disorganized and unprofessional. He also violated HIPPA guidelines by sending lab results and consultation reports to wrong doctor's office.
Dr. Hakim and his staff are the best. I could not have received better and more compassionate care for my Bladder Cancer. all was a success. Very thorough and professional.They worked well with my work schedule.
Dr. Hakim is an excellent phyiscian. He's very caring and personable. Great technical skills. Wonderful office staff. I love this guy.
Dr Hakim spent an amazing amount of time with me explaining both my physical situation and also recommendating appropriate treatment. Truly a caring and personable physician, who was able to answer my questions in a straightforward and non-condescending manner. I would recommend his services to anyone!
Dr. Hakim is a very professional and has a excellent bedside manner.. It made a scary situation not so scary...
Dr. Hakim is very kind, I have reccommended him to a few of my husbands friends. HE was very helpful and didn't "beat around the bush" with anything, he was upfront and honest. We truly appreciated all of his help.
He took care of my husband's kidney stone after he was in Emergency three times. Where did he go?? We liked him.
This doctor was relatively new to the area so I checked his history at the local hospitals before I saw him in the office. The nurses in surgery and other staff had only good things to say, so I let him do 2 surgeries on me. The surgeries were a success. He had great communication with me, and had great bedside manner. He really explained everything to me. I am very thankful that he is such a good doctor!
This physician was extremely caring, and accurate in diagnosis and treatment. Called me at home after every surgery and office procedure to check on my condition. I highly recommend him!
Dr. Hakim is an enthusiastic doctor who genuinely cares for his patients. He provided great care to me and my family, and I would strongly recommend him to anyone who needs urologic care.
I was in a lot of pain from a kidney stone that would not pass. He did my case that night but did not let me go from the hospital till the next day.
My husband had a kidney stone and was in the ER three times; Dr. Hakim had it out that night. We were very happy.
He did surgery on my Dad and called him that night to check up on him. We were pleased with him.
Very Bad


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Top Definition
a word that can be used to describe a black person without insulting them with them knowing.
This word is relativley close to nigger.
This word is relativley close to nigger.
I fucking hate mondays!
av NyC4LyFe 21 maj 2007
Trending Now
Can you define these popular missing words?
The reason Sunday's suck.
Monday...rarely are they worth noting.
av Jakabones 12 augusti 2006
The biggest waste, of exactly one seventh of your life.
oh crap, tomorrow is MONDAY!!!
av Eric Gardner 27 november 2007
Another slang term for a gentlemen of the black race. Used repeatadly when in the presence of black or other ethnic minorities to avoid ugly confrontation, causing uncomfortable silence resulting in physical violence, known to them as "Cracker Beating". Origin from the cliche' saying... 'Nobody Likes Mondays'
Man, were you at the basketball game, that Mondays got hops
This party is terrifying me, too many Mondays around
This party is terrifying me, too many Mondays around
av BeeFrank 23 april 2006
The beginning of the schoolweek (and, for most people with decent occupations, the workweek). Its beginning puts almost everybody in a bad mood, but its end does little to enliven the spirit.
Monday is the first of the five major obstacles that our hero must pass before reaching the hallowed 'week's end'.
av Diggity Monkeez 21 februari 2005
someone or something you hate with an extreme prejudice.
I hate that Fucker Tom, he's such a fuckin' Monday
av R U N? 25 oktober 2004
When you realize the weekend is over, and you have to give up 40+ hours at a shitty job just to earn enough to eat and have shelter.
Looks like someone has a case of the Mondays.
av karma 11 juni 2004