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Mirrored from djkirkbride.com.
I can't believe it's all over! Event(s) info HERE.
4 years. 30 issues. The best creative times of my life so far.
Thanks to all of our readers– and if you haven't read it, all 30 issues are available on ComiXology.
The grand finale of my THE BIGGEST BANG #1 signing mini-tour will be at Golden Apple Comics on Melrose Ave in Los Angeles this Saturday, May 28th, from 12pm to 4pm!
There will also be a huge announcement regarding a surprise upcoming superstar store signing at 1pm that day. They'll be handing out line passes to 50 lucky comic fans, so if that mystery double-entices you, all the better!
So swing by for the mystery guest info, then buy a singed copy of my new IDW Publishing cosmic superhero mini-series– it's a win win!
THE BIGGEST BANG #1 is out next week from IDW Publishing, so I'm doing a tiny California signing tour: May 18 at both The Comic Bug Culver City and Manhattan Beach, May 21 at Sterling Silver Comics in Camarillo and May 28 at LA's own Golden Apple Comics!
UPDATE: Pulp Fiction Book & Comics in Culver City has been added to the tour on May 25!
Stop by one if you can, and please spread the word!
Today's the final order cutoff (FOC) for IDW Publishing's THE BIGGEST BANG #1! If you want to be 100% sure your local comic shop has a copy for you when it comes out on May 18th, let them know before they close this evening! (You can still tell them you want it after today or just snag it on the stands after it's released, but today's when shops place their final initial orders. If comics were movies, the FOC is kind of how the opening weekend box office is determined.)
If you're on the fence about the book, check out what some of the best comic creators in the business had to say about it in the image above.
Here's the official solicit:
Publisher: IDW PUBLISHING
Writer: D.J. Kirkbride Artist: Vassilis Gogtzilas
Letterer: Frank Cvetkovic Editor: Justin Eisinger
Born in the cataclysmic cosmic catastrophe known as "The Bigger Bang," Cosmos traversed the barren egg-lands in-between universes, discovered the wisdom of space whales, defeated intergalactic evil, and found love! Now a new threat presents itself, one the hero has never known… worship! What can he give those who would call him God? Intergalactic action and pataphysical philosophy return in THE BIGGEST BANG, the thrilling sequel to the mini-series Den of Geek called one of "the best comics of 2015"!
Item Code: MAR160383 (standard) MAR160384 (variant)
In Shops: 5/18/2016
Cover Price: $3.99
Please spread the word and help build up the excitement! Thanks, and hooray for comics!
In nigh four days, Adam P. Knave and I are representing team Amelia Cole at Emerald City Comicon table A-18! We'll have all 4 volumes of AMELIA COLE, NEVER ENDING, THE BIGGER BANG, and DARK HORSE PRESENTS issues 19 & 20, featuring LASER JOAN AND THE RAYGUNS! Fun will be had!
Forgive me if this seems braggy, but I can't help it! For the first time in my 80 years on this earth, I have three comics featuring words co-written by me (with the Hall to my Oats, Adam P. Knave) coming out in one day. It's nutty.
AMELIA COLE #26: The End of Everything Part 2
The final arc charges forward as Amelia tries something CRAZY. So crazy, it just might work. Probably. (Check out that glorious Nick Brokenshire cover! And this one also has a cool Amelia Cole pinup by none other than Eisner Award winning Bandette co-creator Colleen Coover!)
LASER JOAN and THE RAYGUNS part 1 (of 3) in DARK HORSE PRESENTS #19
Famous pop stars / secret secret agents! Sound familiar? Maybe, but the story's never been told like this before! Adam, artist Robert Wilson IV, and I created these characters back in 2011, so it's great to finally have them out there for readers to see — in all the awards winning Dark Horse Presents, no less!
BILL & TED'S MOST TRIUMPHANT RETURN trade collection
Adam and I contributed a backup story to the third issue of this most excellent follow-up to the Bill & Ted movies with artist Wook Jin Clark— and it's included in this non-non-non heinous trade collection!
So, please, check out these comics and keep an eye out for new work on the horizon. Thanks so much!
That's right! I'll be a writer in artist alley at this year's LONG BEACH COMIC EXPO on February 20th & 21st, selling and signing copies of all four IDW volumes of AMELIA COLE, THE BIGGER BANG issues 1 – 4 (plus the snazzy trade collection), and the Dark Horse NEVER ENDING trade paperback.
There's also a cool panel that I get to participate in with the likes of Jimmy Palmiotti, Tony Donley, and Megan Hutchison! Here's the info:
#MakeComics: The Advantages of Creator Owned Comics
Moderator: Marcus Perry
Description of Panel: Playing in others' sandboxes is fun, but sometimes doing your own thing can be just as fulfilling. Join Jimmy Palmiotti (Painkiller Jane, Hype), Tony Donley (Albert Einstein: Time Mason), D.J. Kirkbride (Amelia Cole, Popgun Anthology from Image Comics), and Megan Hutchison (The Aurora Grimeon Stories) to talk about why creating their own work is necessary as well as rewarding. Moderated by Marcus Perry (co-creator of Albert Einstein: Time Mason and Descendant from Image Comics).
Panel date: Saturday, February 20th
Panel time: 1:30pm-2:30pm
Room name/number: Creator's Lab, S5


text:
Created in this Craftsy class
Bake the perfect cake every time! Learn the skills to make a classic yellow cake with rich chocolate filling and scrumptious buttercream icing.
Other projects made as part of this class:
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
|Here are some details about my project:
|Cake Decorating
|Any Occasion
|2 Tier
|Colorful, Traditional
Share a little about the materials, processes and techniques used to create this cake: Materials anodized aluminum 9" x 2" round cake pans, Bake Easy! spray, Funfetti cake mix (2 - 1 per layer), butter cream icing with tint, raspberry preserves, 2 disposable piping bags, 2 couplers, 3 tips (shell, star, and round) Processes/Techniques Cake Baking, Mixing Icing, Tinting Icing, Icing cake, Smoothing Icing, Piping a Dam, Filling a Cake, Creating a Border
The fish was free-handed and I really should have leveled the cake first...

subset: commoncrawl


text:
Tenders Are Invited For Repair Of Public/community/cultural Building In W No. 18 At Balod
Tender Value:
Rs. 1.55 Lakhs/-
Project Period:
3 Months
Rs. 2000/-
Document Fees:
Rs. 300/-
Authority Type:
Public Sector
Notice Type:
Domestic Tender Notice
Building Repair Services
Tender Publish Date:
Document Sale Ends:
Document Submit Before:
Tender Due Date:
07-OCT-165 Days left
Only Registered Contractor/Bidder Can Apply In This Bid.Bidder Must Submit Registration Certificate, Pan No., Commercial Tax Certificate, Tin No., Income Tax Clearance Certificate, Bank Solvency Not Before 1 Year, Income Tax Return Copy For Previous Year, Mineral Royalty, Epf Certificate, Labor Registration Certificate For This Bid.
Not Mentioned


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Home > Sunglasses > Pierre Cardin > P.C. 6189/S (LHD/X1)
P.C. 6189/S is available in 3 additional attractive styles
New Releases
Size and availability
Free outbound and return shipping
30-day money-back guarantee
Low prices
Free outbound and return shipping
30-day money-back guarantee
Low prices
P.C. 6189/S/LHD/X1 Ophthalmic Glasses
These sunglasses complement your look with an accessory that is a cut above the rest. True to the Edel-Optics motto "SEE AND BE SEEN", you are on a par with celebrities, impressing in every environment. The P.C. 6189/S is available in the Edel-Optics online shop in other styles from Pierre Cardin collections 2015 and 2016.
The frame is specially designed for men. Sporting clear lines, New School Cool meets traditional quality. Full rim frames completely enclose the lenses within the frame. For a convinced eyeglass wearer, any other frame style is ruled out, with very few exceptions. The quadratic shape makes the face appear longer, due to its straight outer edges. The frame is, therefore, particularly advantageous for more rounded facial features. Plastic frames like these combine durability and are comfortable to wear. The P.C. 6189/S is a very snug fit on the ears and nose. Brown is the perfect alternative for those who find black too high in contrast. Brown flatters the face unobtrusively. Orange coloured lenses are good for sport, especially when it is important to enhance contrasts. Functionally, you are, of course, on the safe side, too. With 100% UV eye protection, the sun can immediately start shining.
The respective lenses are also available in your prescription strength. Our digital dispensing optician will help you find the cheapest option.
The next shipment is on its way, so we will have your Pierre Cardin back in stock very soon. We hope the unbelievably low price will be a consolation for the short wait. If you buy at Edel-Optics you get the best price, because "in the sale" is our standard.
New Releases
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Don't hesitate to call us at
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text:
Custom Rear Deck Dual 12" Subwoofers! [+ build pics]
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Join Date: Nov 2010
Location: Baltimore
Posts: 1,363
My Ride: '01 325xi, '90 325iC
View My Garage
I don't have the specs on me here at college, but I did build it to the minimum square footage believe it or not. In my first setup (the single box in my trunk) I didn't take into account the driver itself which takes up a ton of room. However, for this install, I did infact take the drivers into account. That is why my box is awkwardly mushroom shaped lol. So yes, it is the appropriate size for the speakers.
Thanks for the comment! It's holding up great, no squeaks or nuffin! I just recently redid my C pillars and 3rd tail light cover in the same black trim. It looks so much nicer now
Too bad its hilariously hard to take pictures of the interior headliner/rear pillar area
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text:
Atmospheric Pressure Corona Discharge
Application ID: 14035
This model simulates a negative corona discharge occurring in between two co-axially fashioned conductors. The negative electric potential is applied to the inner conductor and the exterior conductor is grounded. The modeled discharge is simulated in argon at atmospheric pressure.
This application was built using the following:Plasma Module
The combination of COMSOL® products required to model your application depends on the physics interfaces that define it. Particular physics interfaces may be common to several products (see the Specification Chart for more details). To determine the right combination of products for your project, you should evaluate all of your needs in light of each product's capabilities, consultation with the COMSOL Sales and Support teams, and the use of an evaluation license.


text:
Revelstoke is fast becoming known as a hub for adventure in the mountains. World famous for its huge 16m-20m snowfall each year, the skiing and snowmobiling in 'Revy' is nothing short of a dream come true for powder hounds all over the planet.
Glacier House Resort and Great Canadian Tours team up over the winter months to offer spectacular snowmobile tours right from the hotel front door.
Great Canadian Tours has over 20 years experience in the backcountry, and is the only certified organization in Revelstoke to offer guided snowmobile tours and rental packages on the latest snowmobiles. Shred the powder, cut fresh lines on the slopes, explore the trails and massive freeride terrain that all begin just meters from your Lodge room or cabin with direct mountain access from Glacier House Resort. Frisby and Boulder mountains have a vast groomed trail network to take you right up into the alpine, and our Guides are guaranteed to know where the best snow can be found!
From short snowmobile tours, to multiday adventures, to the brand new, action packed Heli-High Tour with snowmobiling, heli-skiing, BBQ's and more, Great Canadian Tours really does have something for everyone!
Find out more about snowmobiling in Revelstoke at riderevelstoke.ca
A short distance away from Glacier House Resort, Revelstoke Mountain Resort offers lift, cat, heli and backcountry skiing from one village base. Be amazed at the longest vertical descent in North America, 1,713 metres (5,620 ft) of lift-accessed terrain, 3,121 acres of fall line skiing, 2 high alpine bowls, and 65 named runs, including legendary glades and phenomenal groomers.
As well as world class lift-assisted skiing, Revelstoke is notorious for its outstanding ski touring – base yourself at Glacier House Resort, put on your skins, and tour into the backcountry on muscle power alone. Experience the peaceful majesty of your surroundings and deep untouched champagne powder!
Or spend a day discovering the Mt Macpherson Nordic cross country ski trails and loops through beautiful snow covered forest.
Ski and Stay packages - Starting from $116 per person*
Enjoy convenience and great value by purchasing Revelstoke Mountain Resort 'direct to lift' tickets with your accommodation at Glacier House Resort.
Package includes accommodation plus a 'direct-to-lift' day ticket at Revelstoke Mountain Resort, plus complimentary shuttle to and from the ski hill upon request. Prices do not include tax. Prices may change depending on seasonal rates.* Rates are subject to change throughout the winter season.
We are happy to be working with Revelstoke Snowshoe Company again in 2016.
Snowshoeing is a great way to explore winter landscapes. One reason this activity is gaining such popularity is that it caters to a wide variety of age groups, fitness and experience levels. If you have never been snowshoeing, fear not, if you can walk you can snowshoe.
Join us for a ride on the Revelation Gondola and a guided tour through beautiful trails in the sub-alpine forests of the Selkirk Mountains.
Or why not arrange a custom guided tour just for you and your group, right from your door at Glacier House Resort? It's the perfect way to discover the winter wonderland right outside!
Along the way our knowledgeable guides can teach you about local plant and animal species, wildlife tracking, local history, and winter survival. On the trek you can expect some spectacular views (weather permitting of course), signs of wildlife, and a whole new adventure on the snow. Great for families!
Contact us for more information, or check out the Revelstoke Snowshoe Company website.
If you prefer to explore on your own, snow shoes are available to rent from Glacier House Resort. Please see Front Desk when you arrive!


text:
Other projects made by Steffa:
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
|Here are some details about my project:
|Funky, Casual
What advice would you give someone starting this project? -Take your time. I completed the dress in three short sessions. -You may need to add one size to the measurements indicated on the package. My measurements were for size 18, but 20 was the correct fit of this type of garment. -Don't be afraid to adjust where you place the ties at the side for a more tailored fit. -I wish I had enough bias to trim the bottom hem, but the pattern only called for one package which was not enough.
Pretty fabric! It must be fun to wear something you made to work.
Very nice. Although it was your first clothing project, it would appear that you have very good instincts for garment construction. I suspect you're going to have alot of fun with clothing.
I am going to be making this and I may need some pointers....


text:
The 22-year-old pitcher who was ranked sixth overall by ITW in the pre-season prospect rankings, has been struggling with slow starts to games. Spoone, who said he was limited to 85 pitches in his first three starts back, attributes the slow start to mechanical issues and control.
"I think my mechanics start to get too out of sync in the beginning, and then it comes to me, but tonight I did walk a couple guys in the beginning," Spoone told ITW after shutting out Altoona through six innings on June 28. "I can handle it when it's 2-2, 3-2, foul-off, walk, I can handle that. I can't handle ball one, ball two, ball three, strike, ball four. I can't handle almost four straight balls to walk a guy because you're never around the strike zone. At least tonight, when I [walked batters], I was in the zone a lot better."
Spoone's new catcher, Matt Wieters, also noticed the early struggles to late success pattern in his first game catching Spoone.
"[Spoone] had great stuff and you have to make sure you don't let him try and do too much," Wieters said. "When he tries to do too much he over throws, but once he settles down, he was good for the last four innings."
Bowie pitching coach Mike Griffin also echoed some of the problems Spoone has had in regards to slow starts.
"That's what we've seen since he's come back, [Spoone] starts slow and finishes strong," Griffin said. "Yesterday, the slow, got a little bit better, and his finish got a little bit longer. It lasted only about an inning and a half instead of two or three."
As for the mechanical inconsistencies, Griffin said that the mechanical adjustment is about keeping his head in place when Spoone is pitching.
"It's pretty simple and he was able to correct it [on June 28]," Griffin explained. "It's something minor for a pitcher and he made the adjustment [on June 28]."
Even though Spoone has struggled with his control since coming back, when he has been in the strike zone and getting batters out, he has been on top of his game. In June Spoone posted a 2.98 Go/Ao ratio and in his most recent start, Thursday, he struck out seven, induced six grounders, and had just one popup (the only other out was a base runner caught stealing). This is right on par with last year's 2.68 Go/Ao ratio in Frederick.
When Spoone's heavy 91-93 M.P.H. fastball is in the zone, all opponents can do is pound it into the ground, but when he lacks command he, like any other pitcher, will struggle. Orioles Director of Scouting Joe Jordan said Spoone can be tough to catch when he is all over the place, but it is now time for Spoone to take his game to the next level.
"Chorye, at the end of last year, was our best minor league pitcher, and no one was close to him with what he did in August and September," Jordan told ITW. "I think the setback affected that, but what we saw [June 28] was hopefully a start of getting on another one of those runs."
With a second spring training out of the way, it is now, according to Jordan, also time to continue his growth as a pitcher.
"He's grown so much as a pitcher the last year. He knew [June 28] about the fourth inning that his best pitch was the sinker. For me that's growth. That's really starting to understand what you are."
If you have any questions or comments, please send an e-mail to email@example.com


text:
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text:
Crime and Justice in America
2nd Edition
An Introduction to Criminal Justice
- eBook ISBN 9781437735130
- Print ISBN 9781437735123
An Introduction to Criminal Justice
This textbook offers a concise, affordable, and reader-friendly introduction to the criminal justice system. It explores the system in four sections: the criminal justice system as social control, law enforcement as social control, the law as social control, and corrections as social control.
Designed with the student in mind, each chapter includes: "What You Need to Know," highlighting key points for the reader; brief chapter outlines; review questions; vocabulary lists; a "breaking news" box and exercises to help students customize the material for different jurisdictions.
Students in the criminal justice field
"In this update of the 2008 text, Pollock (criminal justice, Texas State U.-San Marcos) emphasizes the law and due process as they relate to each subsystem of the criminal justice system as a means of social control. Chapters include updated statistics, a new 'breaking news' feature, state-specific examples, snapshots of certain types of crime, consideration of women and minorities in each, review questions, exercises, vocabulary definitions, and Internet references. Tips on writing a research paper are appended."--SciTech Book News


text:
(T-G Photo by Mary Reeves) [Order this photo]
"Josh Carlock is good friends with his grandson, Joel (Johnson)," said Fire Chief Jeff Phillips. "He made the phone call and Joel is going to carry on the family tradition."
Joel's brother, Adam, is also donating his skills as an auctioneer for the event. The community has been very generous to the cause and the items donated for the auction include a load of gravel, a new gun, kitchen appliances, automotive supplies, tools, tarps, gift certificates and coupons, just to name a few of the many items. The chili supper will take place Saturday from 6 to 9 p.m. Besides the auction, there will be live music, produced by Duane Drake and the Double Take band.
Like all other volunteer fire departments, Wartrace has to be creative when raising funds. Although there are grants and federal, state and local supplements, much of the operating budget is raised by the volunteers and their families. The Wartrace department has a turkey shoot every year, as well as other projects, but this is the first time they've opted for a chili supper.
"We want to try to get more involved with the community and we want the community to get more involved with us," said Josh Sowers, another volunteer firefighter.
Volunteer recruitment is an ongoing campaign at almost every volunteer fire hall, said Phillips.
"We can always use more help down here," he said.
Some of the money is earmarked for improvement at the fire hall and making it a friendlier, more comfortable environment for the firefighters and their families, said Phillips.
"If it's nice, they'll want to hang out down here, and if there are more people down here, that means we've got more people on call," he said.
The funds raised are also used for equipment and training, which every fire department has to upgrade constantly. He hopes anyone interested will speak up at the chili supper.
"Now is a real good time to get started," said Capt. Rodney Schmiede. "The 16-hour training class is in May and it's mandatory. If they sign up now, they'll be able to fight fire sooner."
Tickets for the chili supper are $5 each and can be purchased at the Wartrace fire hall.


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Marshalls Premier Mortars & Screeds is one of the UK's largest independent suppliers of mortars, screeds, renders and modified sands.
Wholly owned as a Marshalls specialist business since 2004, Marshalls Premier Mortars & Screeds provides a comprehensive and continuously expanding portfolio of products, whilst investing in its people, services and manufacturing technology. All products are produced to tested designs by computer technology and are CE marked in accordance with current EU directives. The business has been declared an Investor in People and a recent Best Companies staff survey achieved 2 Star status. Our growing network of plants continues to strengthen our position as market leader for ready-to-use mortars and screeds. We will be establishing ourselves in new geographical regions in 2016, providing additional coverage between Bedfordshire and the South Coast. Experienced specialists are available to advise you on product information, prices and availability according to your requirements.
Next day delivery - Marshalls Premier Mortars offer a next day delivery or same day collection service from any of our regional depots. For a small fee you can choose your time!
Made in Britain - All Marshalls Premier Mortars products are manufactured from sustainable UK materials.
Free colour mortar samples - Request free mortar samples online and we will hand deliver personally to site allowing you to colour match from our extensive Coloured mortar range creating a traditional finish or a contemporary aesthetic look.
Flexible payment methods - Because Marshalls Premier Mortars are a subsidiary of Marshalls group, we offer flexible payment options that include, 30 day account, credit-debit card or via merchant trade.
Customer service charter - Here at Premier we pride ourselves on customer values and service, we have experienced staff at every step of your project that are friendly and honest and will offer assistance when ever and where ever needed.
Marshalls Premier Mortars and Screeds' Bridgwater plant is now supplying a flowing screed which we are calling 'Marshalls Premflow', this is a high quality pumpable self compacting flowing screed!
Marshalls Premier Mortars and Screeds supplies black mortar to help complete The Royal Mint Visitor Centre in South Wales


text:
Area of extremely high concentration of activating brake lights and stop lights found in and around urban areas.
I hate riding in the red light district. Too many red lights!
by Rock6Times May 03, 2010
Originates in a parking garage in Amsterdam where the top floor is full of CLEAN prostitutes. Today it is slang for where prostitutes in cities really congregate and work the blocks.
WE got a 560 in the red light district, apparently an officer was in a gas station and a prostitute aproached him and when he tried to arrest her she shot at him.
by True Nigga April 09, 2005
A district of a city where breaklights of cars are always on beause of stopping, mainly for hookers but also for drugs, ect ect ect......
'Lets take Jon to the Red Light District for his batchlor party'
by Gord0h January 13, 2004
East St. Louis, On Dr. Martin Luther King Blvd. Also a haven of crack addicts and burnt down meth labs.
Not the most wonderful place to take the family for vacation.
Not the most wonderful place to take the family for vacation.
I went to the East Side last night into the red light district to find some rocks and a prostitute.
by MikeS. November 18, 2007
A place where you can find hookers, thugs, gangstas, and mostly projects
The red light district is only for the hardest niggas. We shouldn't go there
by Anonymous August 21, 2003
the big red light district is amsterdam sex cinemas gay cinemas for guys only prostitute houses and red lights everywhere girls in glow in the dark outfits ppl tryin to pick up any one clubs and more clubs and red lights out side the houses basically mean some prostitute is workin
red light district is amsterdam
by livia April 23, 2006
rap in the south. which is never involved in the rap war between the east coast, and west coast.
50 cent ( west coast ) ,fat joe (east coast) ludacris ( red light district)
ludacris is neutral
ludacris is neutral
by lebron johnson March 05, 2005


text:
With 1.7 million freelancers, we'll match you with the perfect talent.
Around 5+ years of experience in the field of Information Technology, specializing in Software Development.
Strong knowledge of OOPS concepts.
Expertise includes Software Development using VB, ASP, .NET Technology
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Knowledge of .Net 3.0
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text:
Market Research Report
Dental Implants | North America | 2015 | Market Analysis
|Published by
|Decision Resources Group - Medtech Solutions
|Product code
|Content info
Delivery time: 1-2 business days
|Dental Implants | North America | 2015 | Market Analysis
|Published: June 18, 2015
|Content info: Pages
Increasing numbers of GPs providing dental implants will create greater access to and patient awareness of dental implant treatments, leading to strong procedure volume growth and market expansion through 2023.
This Medtech 360 Report provides comprehensive data and analysis on the current state of the market for dental implants in North America, with market projections across a 10-year period.
Geographies Covered: US, Canada.
Market Forecast Features: Based on primary research with industry professionals, Millennium Research Group uses its proprietary forecasting model to provide an in-depth examination of current and future trends in procedure volumes, unit sales, ASPs, and market values over a 10-year period (2013-2023).
Competitive Analysis: Millennium Research Group provides a detailed analysis of the competitive landscape and market shares for leading competitors.


text:
Phuket Real Estate, idyllic island paradise, shopper's dream, unspoilt
natural environment and an investment in your future. Let us,
at PHUKET ONE REAL ESTATE, show you the large array of properties for sale on our beautiful island. Let us advise and assist you
with every facet of purchasing your dream home. At PHUKET ONE,
we promise to live up to our motto – "Making you
number one."


text:
The calendar flips back a generation or so and in your mind's eye you see the two of them striding purposefully down a long, sweeping fairway, a duel in the sun, men intent on a mission, jaws set and eyes locked on a target only they can see, one golden-maned and recently shed of 30 pounds, and the other hitching at his pants and flipping away one of those damnable cigarettes he's trying to quit.
Jack and Arnie.
Arnie and Jack.


text:
|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
Big Bad Booty Daddy
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Comments Thread For: Casimero vs. Rios IBF Purse Bid Won By Sampson
BoxingScene.com has been advised that Sampson Boxing submitted the winning bid in for the IBF's mandatory fight between junior flyweight champion John Riel Casimero (17-2, 10KOs) of the Philippines and mandatory challenger Luis Alberto Rios (18-1-1, 13KOs) of Panama.
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text:
Best route map between Tulsa, OK and Minocqua, WI. This route take about 927 Miles.
The distance and estimated time is placed on the right depending on the status of the road.
, 05:38
* You can see Tulsa, OK and Minocqua, WI photos above. We provide this photos from Google Panoramio service.
* Tulsa, OK weather as celsius: °C
* Minocqua, WI weather as celsius: °C
* Weather information on route, provide by Open Weather Map.
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Brielle Pietrafesa knows what many people think when she walks to the plate and digs her cleats into the dirt in the batter's box.
"She's so little."
Standing 5-foot-2, Pietrafesa figures there's any number of ways she can show that her height doesn't matter when it comes to success on the softball field.
She can play strong defense at shortstop.
She can hit for average.
She can hit for power.
Double check.
"It's weird," said Pietrafesa, a recent Paul VI graduate who is The Inquirer's South Jersey Player of the Year in softball. "I think people still underestimate me because of my height and size.


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Peter Jackson 'eviscerated' 'The Hobbit,' 'LOTR,' says Tolkien son
Christopher Tolkien, son of J.R.R. Tolkien and executor of his father's literary estate, expressed disappointment in the films made of the books by Peter Jackson.
During his first interview in 40 years in June, with the French publication Le Monde, Tolkien, 87, said that Jackson "eviscerated the book by making it" into "an action movie for young people aged 15 to 25," he said of the "Lord of the Rings" films. "And it seems that 'The Hobbit' will be the same kind of film." »Read Full Blog Post(1)
Yo La Tengo swings from calm to full-on rocking
Yo La Tengo's show at Turner Hall on Saturday showed that in music, there are different types of Zen.
The Hoboken, N.J.-based indie rock darling began a nine-song opening acoustic set with a meditative variation of "Ohm," the first track off "Fade," its lovely and relaxed 13th full-length studio album released in January. Georgia Hubley gently tapped the drums with brushes, her husband Ira Kaplan glided the song toward a subdued Middle Eastern-influenced guitar jam, and the couple along with primary bassist James McNew sang sweetly, quietly, together. »Read Full Article
MSO captures excitement of rarely performed Beethoven works
In the culinary world it's quite the event to plan a meal around a single delicacy, for instance a white truffle meal.
In the music world, it's a similar treat to plan a meal around a musical delicacy, for instance some of the infrequently performed symphonies of Beethoven. »Read Full Article
Milwaukee Rep's 'Clybourne Park' an electrifying production
Because "Clybourne Park" is so good and because it explores issues that aren't going away, it's easy to agree with Mark Clements' prediction - made in his director's notes for the new Milwaukee Repertory Theater production - that Bruce Norris' play is built to last.
It's much harder to imagine watching the inevitable revival, 10 or 20 years from now, without hearkening back to the electrifying performance I saw Friday night, in which Clements' all-star cast gave "Clybourne" the treatment it deserves. »Read Full Article(1)
Winter Jam tour brings full range of Christian music to U.S. Cellular Arena
The Christian music industry has long been a bit of an enigma.
Mostly, the genre has remained separate from its pop brethren. There it has thrived, in record sales, at festivals and on Christian radio. »Read Full Article(3)


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Boston Marathon suspect boasted of his bomb-making skills: prosecutor
Friend's obstruction trial hears of martyrdom discussions a month before marathon attack
Related topics
Boston marathon bombing suspect Dzhokhar Tsarnaev told a friend a month before the attack that he knew how to make a bomb, a US prosecutor told jurors at the friend's obstruction trial.
He also said it's good to be a martyr because you "die with a smile on your face and go straight to heaven", Assistant US Attorney Stephanie Siegmann said.
Ninety minutes after the bombing, Tsarnaev texted the friend, Azamat Tazhayakov, and said, "Don't go thinking it's me", Siegmann also told the court on Monday during opening statements at Tazhayakov's trial.
Tsarnaev is scheduled to go on trial in November on charges that carry the possibility of the death penalty. Prosecutors say he and his older brother, Tamerlan, built two bombs and placed them near the finish line of the 2013 marathon to retaliate against the US for its actions in Muslim countries. The explosions killed three people and injured more than 260. Tamerlan Tsarnaev died following a shoot-out with police days later.
Tazhayakov, 20, has pleaded not guilty to obstruction of justice and conspiracy charges. He and his roommate, Dias Kadyrbayev, went to Tsarnaev's university dormitory room several days after the bombing and took a laptop computer and a backpack containing fireworks that had black powder spilling out or had been emptied of their powder, Siegmann told the jury.
"The government will prove to you that the defendant and his co-conspirator removed the backpack … to protect their friend," Siegmann said.
Prosecutors acknowledge that Kadyrbayev is the one who actually threw away the backpack but said Tazhayakov agreed to get rid of it.
Tazhayakov's defence lawyer, Nicholas Wooldridge, urged jurors not be swayed by the emotional impact of the bombings.
"Azamat's actions will show that he never intended to obstruct justice. As a matter of fact, he never intended to help the bomber himself," he said.
Wooldridge said Tazhayakov went to Tsarnaev's dormitory room with Kadyrbayev three days after the bombings and hours after the FBI released video footage and photos of the brothers. Tazhayakov watched a movie while his friend looked around the room, then threw the backpack away, he said.
"Azamat never even touched that bag," Wooldridge said.
Kadyrbayev goes on trial in September.
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Fixed-Price - Entry Level ($) - Est. Budget: $60 - PostedSkills: Prolog Artificial Neural Networks
Write a game bot in prolog. It can be any game that can run in windows itself or via game emulator, similar to these videos. https://www.youtube.com/watch? ... v=qv6UVOQ0F44 http://www.cs.cmu.edu/~tom7/mario/ You can rewrite the code given in the video descriptions for Prolog.


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(ri TUK si mab)
Index Terms
- Anti-CD20 Monoclonal Antibody
- C2B8 Monoclonal Antibody
- Rituximab, inj
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intravenous [preservative free]:
Rituxan: 10 mg/mL (10 mL, 50 mL) [contains polysorbate 80]
Brand Names: U.S.
- Rituxan
Pharmacologic Category
- Antineoplastic Agent, Anti-CD20
- Antineoplastic Agent, Monoclonal Antibody
- Antirheumatic Miscellaneous
- Immunosuppressant Agent
- Monoclonal Antibody
Rituximab is a monoclonal antibody directed against the CD20 antigen on B-lymphocytes. CD20 regulates cell cycle initiation; and, possibly, functions as a calcium channel. Rituximab binds to the antigen on the cell surface, activating complement-dependent B-cell cytotoxicity; and to human Fc receptors, mediating cell killing through an antibody-dependent cellular toxicity. B-cells are believed to play a role in the development and progression of rheumatoid arthritis. Signs and symptoms of RA are reduced by targeting B-cells and the progression of structural damage is delayed.
IV: Immediate and results in a rapid and sustained depletion of circulating and tissue-based B cells
Uncertain; may undergo phagocytosis and catabolism in the reticuloendothelial system (RES)
Duration of Action
Detectable in serum 3-6 months after completion of treatment; B-cell recovery begins ~6 months following completion of treatment; median B-cell levels return to normal by 12 months following completion of treatment
Half-Life Elimination
CLL: Median terminal half-life: 32 days (range: 14-62 days)
NHL: Median terminal half-life: 22 days (range: 6-52 days)
RA: Mean terminal half-life: 18 days (range: 5-78 days)
GPA/MPA: 23 days (range: 9-49 days)
Use: Labeled Indications
Treatment of CD20-positive non-Hodgkin lymphomas (NHL):
Relapsed or refractory, low-grade or follicular B-cell NHL (as a single agent)
Follicular B-cell NHL, previously untreated (in combination with first-line chemotherapy, and as single-agent maintenance therapy if response to first-line rituximab with chemotherapy)
Nonprogressing, low-grade B-cell NHL (as a single agent after first-line CVP treatment)
Diffuse large B-cell NHL, previously untreated (in combination with CHOP chemotherapy [or other anthracycline-based regimen])
Treatment of CD20-positive chronic lymphocytic leukemia (CLL) (in combination with fludarabine and cyclophosphamide)
Treatment of moderately- to severely-active rheumatoid arthritis (in combination with methotrexate) in adult patients with inadequate response to one or more TNF antagonists
Treatment of granulomatosis with polyangiitis (GPA; Wegener's granulomatosis) (in combination with glucocorticoids)
Treatment of microscopic polyangiitis (MPA) (in combination with glucocorticoids)
Use: Unlabeled
Treatment of Burkitt's lymphoma, central nervous system lymphoma, Hodgkin's lymphoma (lymphocyte predominant); mucosal associated lymphoid tissue (MALT) lymphoma (gastric and nongastric), splenic marginal zone lymphoma; Waldenström macroglobulinemia (WM); post-transplant lymphoproliferative disorder (PTLD); autoimmune hemolytic anemia (AIHA) in children; chronic immune thrombocytopenia (ITP); refractory pemphigus vulgaris; treatment of steroid-refractory chronic graft-versus-host disease (GVHD); refractory lupus nephritis; relapsed/refractory thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), resistant idiopathic membranous nephropathy (IMN), refractory nephrotic syndrome (children)
There are no contraindications listed in the FDA-approved manufacturer's labeling.
Canadian labeling (not in U.S. labeling): Type 1 hypersensitivity or anaphylactic reaction to murine proteins, Chinese Hamster Ovary (CHO) cell proteins, or any component of the formulation; patients who have or have had progressive multifocal leukoencephalopathy (PML)
Dosing: Adult
Note: Details concerning dosing in combination regimens should also be consulted. Pretreatment with acetaminophen and an antihistamine is recommended for all indications. For oncology uses, antihyperuricemic therapy and aggressive hydration are recommended for patients at risk for tumor lysis syndrome (high tumor burden or lymphocytes >25,000/mm3). In patients with CLL, Pneumocystis jirovecii pneumonia (PCP) and antiherpetic viral prophylaxis is recommended during treatment (and for up to 12 months following treatment). In patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), PCP prophylaxis is recommended during and for 6 months after rituximab treatment. For patients with RA, premedication with methylprednisolone 100 mg IV (or equivalent) is recommended 30 minutes prior to each dose.
Chronic lymphocytic leukemia (CLL): IV infusion: 375 mg/m2 on the day prior to fludarabine/cyclophosphamide in cycle 1, then 500 mg/m2 on day 1 (every 28 days) of cycles 2 to 6
Granulomatosis with polyangiitis (GPA; Wegener's granulomatosis): IV infusion: 375 mg/m2 once weekly for 4 doses (in combination with methylprednisolone IV for 1 to 3 days followed by daily prednisone)
Non-Hodgkin lymphoma (NHL; relapsed/refractory, low-grade or follicular CD20-positive, B-cell): IV infusion: 375 mg/m2 once weekly for 4 or 8 doses
Re-treatment following disease progression: 375 mg/m2 once weekly for 4 doses
NHL (diffuse large B-cell): IV infusion: 375 mg/m2 given on day 1 of each chemotherapy cycle for up to 8 doses
NHL (follicular, CD20-positive, B-cell, previously untreated): IV infusion: 375 mg/m2 given on day 1 of each chemotherapy cycle for up to 8 doses
Maintenance therapy (as a single agent, in patients with partial or complete response to rituximab plus chemotherapy; begin 8 weeks after completion of combination chemotherapy): IV infusion: 375 mg/m2 every 8 weeks for 12 doses
NHL (nonprogressing, low-grade, CD20-positive, B-cell, after 6 to 8 cycles of first line CVP are completed): IV infusion: 375 mg/m2 once weekly for 4 doses every 6 months for a maximum of 16 doses
NHL: Combination therapy with ibritumomab: IV infusion: 250 mg/m2 IV day 1; repeat in 7 to 9 days with ibritumomab (also see Ibritumomab monograph)
Canadian labeling: NHL, low grade or follicular: IV infusion:
Initial: 375 mg/m2 once weekly for 4 doses (as a single agent) or 375 mg/m2 on day 1 of each 21-day cycle for 8 cycles (in combination with CVP chemotherapy)
Maintenance (responding to induction therapy): 375 mg/m2 every 3 months until disease progression or up to a maximum of 2 years
Rheumatoid arthritis: IV infusion: 1,000 mg on days 1 and 15 in combination with methotrexate; subsequent courses may be administered every 24 weeks (based on clinical evaluation), if necessary may be repeated no sooner than every 16 weeks
Microscopic polyangiitis (MPA): IV infusion: 375 mg/m2 once weekly for 4 doses (in combination with methylprednisolone IV for 1 to 3 days followed by daily prednisone)
Antibody-mediated rejection in cardiac transplantation, treatment (off-label use): 375 mg/m2 once weekly for 1 to 4 doses (AHA [Colvin 2015]; ISHLT [Costanzo 2010]) or 1,000 mg on days 7 and 21 or on days 7 and 22 (AHA [Colvin 2015])
Chronic graft-versus-host disease (GVHD), refractory (off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Cutler 2006)
Idiopathic thrombocytopenic purpura (ITP; off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Arnold 2007; Godeau 2008)
Hodgkin lymphoma (off-label use): IV infusion: 375 mg/m2 once weekly for 4 weeks (Ekstrand 2003; Schulz 2008)
Idiopathic membranous nephropathy (IMN), resistant (off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses with re-treatment at 6 months (Fervenza 2010) or 1,000 mg on days 1 and 15 (Fervenza 2008) or 375 mg/m2 single doses titrated to B cell response (Cravedi 2007)
Lupus nephritis, refractory (off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Melander 2009) or 500 to 1000 mg on days 1 and 15 (Vigna-Perez 2006)
Pemphigus vulgaris, refractory (off-label use): IV infusion: 375 mg/m2 once weekly of weeks 1, 2, and 3 of a 4-week cycle, repeat for 1 additional cycle, then 1 dose per month for 4 months (total of 10 doses in 6 months) (Ahmed 2006)
Post-transplant lymphoproliferative disorder (off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Choquet 2006)
Thrombotic thrombocytopenic purpura (TTP), relapsed/refractory (off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Scully 2007; Scully 2011)
Waldenström's macroglobulinemia (off-label use): IV infusion: 375 mg/m2 once weekly for 4 weeks (Dimopoulos 2002)
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Pretreatment with acetaminophen and an antihistamine is recommended.
Autoimmune hemolytic anemia (AIHA; off-label use): IV infusion: 375 mg/m2 once weekly for 2-4 doses (Zecca, 2003)
Chronic immune thrombocytopenia (ITP; off-label use): IV infusion: 375 mg/m2 once weekly for 4 doses (Parodi, 2009; Wang, 2005)
Nephrotic syndrome, severe, refractory (off-label use): IV infusion: 375 mg/m2 once weekly for 1-4 doses has been used in small case series, case reports, and retrospective analyses, including reports of successful remission induction of severe or refractory nephrotic syndromes that are poorly responsive to standard therapies (Dello Strologo, 2009; Fujinaga, 2010; Guigonis, 2008; Prytula, 2010)
Dosing: Renal Impairment
No dosage adjustment provided in manufacturer's labeling (has not been studied).
Dosing: Hepatic Impairment
No dosage adjustment provided in manufacturer's labeling (has not been studied).
Withdraw necessary amount of rituximab and dilute to a final concentration of 1 to 4 mg/mL with NS or D5W. Gently invert the bag to mix the solution. Do not shake.
Note: Some pediatric protocols utilize an alternate rituximab administration rate. Refer to specific protocol for administration rate guidelines.
Do not administer IV push or bolus. If a reaction occurs, slow or stop the infusion. If the reaction abates, restart infusion at 50% of the previous rate. Discontinue infusion in the event of serious or life-threatening cardiac arrhythmias.
IV: Initial infusion: Start rate of 50 mg/hour; if there is no reaction, increase the rate by 50 mg/hour increments every 30 minutes, to a maximum rate of 400 mg/hour.
Subsequent infusions:
Standard infusion rate: If patient tolerated initial infusion, start at 100 mg/hour; if there is no reaction, increase the rate by 100 mg/hour increments every 30 minutes, to a maximum rate of 400 mg/hour.
Accelerated infusion rate (90 minutes): For patients with previously untreated follicular NHL and diffuse large B-cell NHL who are receiving a corticosteroid as part of their combination chemotherapy regimen, have a circulating lymphocyte count <5000/mm3, or have no significant cardiovascular disease. After tolerance has been established (no grade 3 or 4 infusion-related event) at the recommended infusion rate in cycle 1, a rapid infusion rate may be used beginning with cycle 2. The daily corticosteroid, acetaminophen, and diphenhydramine are administered prior to treatment, then the rituximab dose is administered over 90 minutes, with 20% of the dose administered over the first 30 minutes and the remaining 80% is given over 60 minutes (Sehn, 2007). If the 90-minute infusion in cycle 2 is tolerated, the same rate may be used for the remainder of the treatment regimen (through cycles 6 or 8).
Stable in NS, D5W
Store intact vials refrigerated at 2°C to 8°C (36°F to 46°F); do not freeze. Do not shake. Protect vials from direct sunlight. Solutions for infusion in NS or D5W are stable at 2°C to 8°C (36°F to 46°F) for 24 hours and at room temperature for an additional 24 hours.
Drug Interactions
Abatacept: RiTUXimab may enhance the adverse/toxic effect of Abatacept. Avoid combination
BCG (Intravesical): Immunosuppressants may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG (Intravesical): Myelosuppressive Agents may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab. Avoid combination
Certolizumab Pegol: RiTUXimab may enhance the immunosuppressive effect of Certolizumab Pegol. Avoid combination
CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine. Specifically, the risk for neutropenia may be increased. Monitor therapy
Coccidioides immitis Skin Test: Immunosuppressants may diminish the diagnostic effect of Coccidioides immitis Skin Test. Monitor therapy
Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. Avoid combination
Denosumab: May enhance the adverse/toxic effect of Immunosuppressants. Specifically, the risk for serious infections may be increased. Monitor therapy
Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid combination
Echinacea: May diminish the therapeutic effect of Immunosuppressants. Consider therapy modification
Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod. Management: Avoid the concomitant use of fingolimod and other immunosuppressants when possible. If combined, monitor patients closely for additive immunosuppressant effects (eg, infections). Consider therapy modification
Leflunomide: Immunosuppressants may enhance the adverse/toxic effect of Leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Management: Consider not using a leflunomide loading dose in patients receiving other immunosuppressants. Patients receiving both leflunomide and another immunosuppressant should be monitored for bone marrow suppression at least monthly. Consider therapy modification
Natalizumab: Immunosuppressants may enhance the adverse/toxic effect of Natalizumab. Specifically, the risk of concurrent infection may be increased. Avoid combination
Nivolumab: Immunosuppressants may diminish the therapeutic effect of Nivolumab. Consider therapy modification
Pimecrolimus: May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Roflumilast: May enhance the immunosuppressive effect of Immunosuppressants. Consider therapy modification
Sipuleucel-T: Immunosuppressants may diminish the therapeutic effect of Sipuleucel-T. Monitor therapy
Tacrolimus (Topical): May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Tofacitinib: RiTUXimab may enhance the adverse/toxic effect of Tofacitinib. Avoid combination
Trastuzumab: May enhance the neutropenic effect of Immunosuppressants. Monitor therapy
Vaccines (Inactivated): Immunosuppressants may diminish the therapeutic effect of Vaccines (Inactivated). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting an immunosuppressant. If vaccinated during immunosuppressant therapy, revaccinate at least 3 months after immunosuppressant discontinuation. Consider therapy modification
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines (Live). Immunosuppressants may diminish the therapeutic effect of Vaccines (Live). Management: Avoid use of live organism vaccines with immunosuppressants; live-attenuated vaccines should not be given for at least 3 months after immunosuppressants. Avoid combination
Adverse Reactions
Note: Patients treated with rituximab for rheumatoid arthritis (RA) may experience fewer adverse reactions.
Cardiovascular: Peripheral edema (8% to 16%), hypertension (6% to 12%)
Central nervous system: Fever (5% to 53%), fatigue (13% to 39%), chills (3% to 33%), headache (17% to 19%), insomnia (≤14%), pain (12%)
Dermatologic: Rash (10% to 17%; grades 3/4: 1%), pruritus (5% to 17%), angioedema (11%; grades 3/4: 1%)
Gastrointestinal: Nausea (8% to 23%), diarrhea (10% to 17%), abdominal pain (2% to 14%), weight gain (11%)
Hematologic: Cytopenias (grades 3/4: ≤48%; may be prolonged), lymphopenia (48%; grades 3/4: 40%; median duration: 14 days), anemia (8% to 35%; grades 3/4: 3%), leukopenia (NHL: 14%; grades 3/4: 4%; CLL: grades 3/4: 23%; GPA/MPA: 10%), neutropenia (NHL: 14%; grades 3/4: 4% to 6%; median duration: 13 days; CLL: grades 3/4: 30% to 49%), neutropenic fever (CLL: grades 3/4: 9% to 15%), thrombocytopenia (12%; grades 3/4: 2% to 11%)
Hepatic: ALT increased (≤13%)
Neuromuscular & skeletal: Neuropathy (≤30%), weakness (2% to 26%), muscle spasm (≤17%), arthralgia (6% to 13%)
Respiratory: Cough (13%), rhinitis (3% to 12%), epistaxis (≤11%)
Miscellaneous: Infusion-related reactions (lymphoma: First dose 77%; decreases with subsequent infusions; may include angioedema, bronchospasm, chills, dizziness, fever, headache, hyper-/hypotension, myalgia, nausea, pruritus, rash, rigors, urticaria, and vomiting; reactions reported are lower [first infusion: 32%] in RA; CLL: 59%; grades 3/4: 7% to 9%; GPA/MPA: 12%); infection (19% to 62%; grades 3/4: 4%; bacterial: 19%; viral 10%; fungal: 1%), human antichimeric antibody (HACA) positive (1% to 23%), night sweats (15%)
1% to 10%:
Cardiovascular: Hypotension (10%; grades 3/4: 2%), flushing (5%)
Central nervous system: Dizziness (10%), anxiety (2% to 5%), migraine (RA: 2%)
Dermatologic: Urticaria (2% to 8%)
Endocrine & metabolic: Hyperglycemia (9%)
Gastrointestinal: Vomiting (10%), dyspepsia (RA: 3%)
Neuromuscular & skeletal: Back pain (10%), myalgia (10%), paresthesia (2%)
Respiratory: Dyspnea (≤10%), throat irritation (2% to 9%), bronchospasm (8%), dyspnea (7%), upper respiratory tract infection (RA: 7%), sinusitis (6%)
Miscellaneous: LDH increased (7%)
Postmarketing and/or case reports: Acute renal failure, anaphylactoid reaction/anaphylaxis, angina, aplastic anemia, ARDS, arrhythmia, bowel obstruction/perforation, bronchiolitis obliterans, cardiac failure, cardiogenic shock, encephalomyelitis, fatal infusion-related reactions, fulminant hepatitis, gastrointestinal perforation, hemolytic anemia, hepatic failure, hepatitis, hepatitis B reactivation, hyperviscosity syndrome (in Waldenström's macroglobulinemia), hypogammaglobulinemia (prolonged), hypoxia, interstitial pneumonitis, laryngeal edema, lichenoid dermatitis, lupus-like syndrome, marrow hypoplasia, MI, mucositis, mucocutaneous reaction, neutropenia (late-onset occurring >40 days after last dose), optic neuritis, pancytopenia (prolonged), paraneoplastic pemphigus (uncommon), pleuritis, pneumonia, pneumonitis, polyarticular arthritis, polymyositis, posterior reversible encephalopathy syndrome (PRES), progressive multifocal leukoencephalopathy (PML), pure red cell aplasia, renal toxicity, reversible posterior leukoencephalopathy syndrome (RPLS), serum sickness, Stevens-Johnson syndrome, supraventricular arrhythmia, systemic vasculitis, toxic epidermal necrolysis, tuberculosis reactivation, tumor lysis syndrome, uveitis, vasculitis with rash, ventricular fibrillation, ventricular tachycardia, vesiculobullous dermatitis, viral reactivation (includes JC virus, cytomegalovirus, herpes simplex virus, parvovirus B19, varicella zoster virus, West Nile virus, and hepatitis C), wheezing
ALERT: U.S. Boxed WarningFatal infusion reactions:
Rituximab administration can result in serious, including fatal, infusion reactions. Deaths within 24 hours of rituximab infusion have been reported. Approximately 80% of fatal infusion reactions occurred in association with the first infusion.
Carefully monitor patients during infusions. Discontinue rituximab infusion for severe reactions and administer medical treatment for grade 3 or 4 infusion reactions.Severe mucocutaneous reactions:
Severe, including fatal, mucocutaneous reactions can occur in patients receiving rituximab treatment.Hepatitis B virus reactivation:
Hepatitis B virus (HBV) reactivation can occur in patients treated with rituximab, in some cases resulting in fulminant hepatitis, hepatic failure, and death. Screen all patients for HBV infection before treatment initiation, and monitor patients during and after treatment with rituximab. Discontinue rituximab and concomitant medications in the event of HBV reactivation.Progressive multifocal leukoencephalopathy:
JC virus infection resulting in progressive multifocal leukoencephalopathy (PML) and death can occur in patients treated with rituximab.
Concerns related to adverse effects:
• Bowel obstruction/perforation: Abdominal pain, bowel obstruction, and perforation have been reported (rarely fatal), with an average onset of symptoms of ~6 days (range: 1-77 days); complaints of abdominal pain or repeated vomiting should be evaluated, especially if early in the treatment course.
• Hepatitis B virus reactivation: [U.S. Boxed Warning]: Hepatitis B virus (HBV) reactivation may occur with use and may result in fulminant hepatitis, hepatic failure, and death. Screen all patients for HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) prior to therapy initiation; monitor patients for clinical and laboratory signs of hepatitis or HBV during and for several months after treatment. Discontinue rituximab (and concomitant medications) if viral hepatitis develops and initiate appropriate antiviral therapy. Reactivation has occurred in patients who are HBsAg positive as well as in those who are HBsAg negative but are anti-HBc positive; HBV reactivation has also been observed in patients who had previously resolved HBV infection. HBV reactivation has been reported up to 24 months after therapy discontinuation. Use cautiously in patients who show evidence of prior HBV infection (eg, HBsAg positive [regardless of antibody status] or HBsAG negative but anti-HBc positive); consult with appropriate clinicians regarding monitoring and consideration of antiviral therapy before and/or during rituximab treatment. The safety of resuming rituximab treatment following HBV reactivation is not known; discuss reinitiation of therapy in patients with resolved HBV reactivation with physicians experienced in HBV management.
• Infections: Use is not recommended if severe active infection is present; serious and potentially fatal bacterial, fungal, and either new or reactivated viral infections may occur during treatment and after completing rituximab. Infections have been observed in patients with prolonged hypogammaglobulinemia, defined as hypogammaglobulinemia >11 months after rituximab exposure; monitor immunoglobulin levels as necessary. Associated new or reactivated viral infections have included cytomegalovirus, herpes simplex virus, parvovirus B19, varicella zoster virus, West Nile virus, and hepatitis B and C. Discontinue rituximab (and concomitant chemotherapy) in patients who develop viral hepatitis and initiate antiviral therapy. Discontinue rituximab in patients who develop other serious infections and initiate appropriate anti-infective treatment.
• Infusion reactions: [U.S. Boxed Warning]: Severe (occasionally fatal) infusion-related reactions have been reported, usually with the first infusion; fatalities have been reported within 24 hours of infusion; monitor closely during infusion; discontinue for severe reactions and provide medical intervention for grades 3 or 4 infusion reactions. Reactions usually occur within 30-120 minutes and may include hypotension, angioedema, bronchospasm, hypoxia, urticaria, and in more severe cases pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation, cardiogenic shock, and/or anaphylaxis. Risk factors associated with fatal outcomes include chronic lymphocytic leukemia, female gender, mantle cell lymphoma, or pulmonary infiltrates. Closely monitor patients with a history of prior cardiopulmonary reactions or with pre-existing cardiac or pulmonary conditions and patients with high numbers of circulating malignant cells (>25,000/mm3). Prior to infusion, premedicate patients with acetaminophen and an antihistamine (and methylprednisolone for patients with RA). Discontinue infusion for severe reactions and serious or life-threatening cardiac arrhythmias. Perform cardiac monitoring during and after the infusion in patients who develop clinically significant arrhythmias or who have a history of arrhythmia or angina. Medications for the treatment of hypersensitivity reactions (eg, bronchodilators, epinephrine, antihistamines, corticosteroids) should be available for immediate use; treatment is symptomatic. Mild-to-moderate infusion-related reactions (eg, chills, fever, rigors) occur frequently and are typically managed through slowing or interrupting the infusion. Infusion may be resumed at a 50% infusion rate reduction upon resolution of symptoms. Due to the potential for hypotension, consider withholding antihypertensives 12 hours prior to treatment.
• Mucocutaneous reactions: [U.S. Boxed Warning]: Severe and sometimes fatal mucocutaneous reactions (lichenoid dermatitis, paraneoplastic pemphigus, Stevens-Johnson syndrome, toxic epidermal necrolysis and vesiculobullous dermatitis) have been reported; onset has been variable but has occurred as early as the first day of exposure. Discontinue in patients experiencing severe mucocutaneous skin reactions; the safety of re-exposure following mucocutaneous reactions has not been evaluated.
• Progressive multifocal leukoencephalopathy: [U.S. Boxed Warning]: Progressive multifocal leukoencephalopathy (PML) due to JC virus infection has been reported with rituximab use; may be fatal. Cases were reported in patients with hematologic malignancies receiving rituximab either with combination chemotherapy, or with hematopoietic stem cell transplant. Cases were also reported in patients receiving rituximab for autoimmune diseases who had received concurrent or prior immunosuppressant therapy. Onset may be delayed, although most cases were diagnosed within 12 months of the last rituximab dose. A retrospective analysis of patients (n=57) diagnosed with PML following rituximab therapy, found a median of 16 months (following rituximab initiation), 5.5 months (following last rituximab dose), and 6 rituximab doses preceded PML diagnosis. Clinical findings included confusion/disorientation, motor weakness/hemiparesis, altered vision/speech, and poor motor coordination with symptoms progressing over weeks to months (Carson, 2009). Promptly evaluate any patient presenting with neurological changes; consider neurology consultation, brain MRI and lumbar puncture for suspected PML. Discontinue rituximab in patients who develop PML; consider reduction/discontinuation of concurrent chemotherapy or immunosuppressants.
• Renal toxicity: May cause fatal renal toxicity in patients with hematologic malignancies. Patients who received combination therapy with cisplatin and rituximab for NHL experienced renal toxicity during clinical trials; this combination is not an approved treatment regimen. Renal toxicity also occurred due to tumor lysis syndrome. Monitor for signs of renal failure; discontinue rituximab with increasing serum creatinine or oliguria.
• Tumor lysis syndrome: Tumor lysis syndrome leading to acute renal failure requiring dialysis (some fatal) may occur 12-24 hours following the first dose when used as a single agent in the treatment of NHL. Hyperkalemia, hypocalcemia, hyperuricemia, and/or hyperphosphatemia may occur. Administer prophylaxis (antihyperuricemic therapy, hydration) in patients at high risk (high numbers of circulating malignant cells ≥25,000/mm3 or high tumor burden). Correct electrolyte abnormalities; monitor renal function and hydration status.
Disease-related concerns:
• Cardiovascular disease: Use with caution in patients with pre-existing cardiovascular disease or prior cardiopulmonary events. Discontinue with serious cardiac arrhythmia.
• Respiratory disease: Use with caution in patients with pre-existing pulmonary disease, or prior cardiopulmonary events.
Concurrent drug therapy issues:
• Biologic agents: Safety and efficacy of rituximab in combination with biologic agents have not been established.
• Disease-modifying antirheumatic drugs: Safety and efficacy of rituximab in combination with disease-modifying antirheumatic drugs (DMARDs) other than methotrexate have not been established.
• Immunizations: Live vaccines should not be given concurrently with rituximab; there is no data available concerning secondary transmission of live vaccines with or following rituximab treatment. RA patients should be brought up to date with nonlive immunizations (following current guidelines) at least 4 weeks before initiating therapy; evaluate risks of therapy delay versus benefit (of nonlive vaccines) for NHL patients.
Special populations:
• Elderly: Use with caution in the elderly; higher risk of cardiac (supraventricular arrhythmia) and pulmonary adverse events (pneumonia, pneumonitis).
• Granulomatosis with polyangiitis (GPA; Wegener's granulomatosis)/microscopic polyangiitis (MPA): The safety of concomitant immunosuppressants other than corticosteroids has not been evaluated in patients with GPA or MPA after rituximab-induced B-cell depletion. There are only limited data on subsequent courses of rituximab for GPA or MPA; safety and efficacy of re-treatment have not been established.
• Rheumatoid arthritis (RA) patients: Monitor RA patients closely during and after each infusion; increased risk of cardiovascular events. Safety and efficacy of re-treatment for RA have not been established. Rituximab is not recommended for use in RA patients who have not had prior inadequate response to TNF antagonists.
Dosage form specific issues:
• Polysorbate 80: Some dosage forms may contain polysorbate 80 (also known as Tweens). Hypersensitivity reactions, usually a delayed reaction, have been reported following exposure to pharmaceutical products containing polysorbate 80 in certain individuals (Isaksson, 2002; Lucente 2000; Shelley, 1995). Thrombocytopenia, ascites, pulmonary deterioration, and renal and hepatic failure have been reported in premature neonates after receiving parenteral products containing polysorbate 80 (Alade, 1986; CDC, 1984). See manufacturer's labeling.
Monitoring Parameters
CBC with differential and platelets (obtain at weekly to monthly intervals and more frequently in patients with cytopenias, or at 2-4 month intervals in rheumatoid arthritis patients, GPA and MPA), peripheral CD20+ cells; HAMA/HACA titers (high levels may increase the risk of allergic reactions); renal function, fluid balance; vital signs; monitor for infusion reactions, cardiac monitoring during and after infusion in rheumatoid arthritis patients and in patients with pre-existing cardiac disease or if arrhythmias develop during or after subsequent infusions.
Screen all patients for HBV infection prior to therapy initiation (eg, HBsAG and anti-HBc measurements). In addition, carriers and patients with evidence of current infection or recovery from prior hepatitis B infection should be monitored closely for clinical and laboratory signs of HBV reactivation and/or infection during therapy and for up to 2 years following completion of treatment. High-risk patients should be screened for hepatitis C (per NCCN NHL guidelines v.2.2013).
Complaints of abdominal pain, especially early in the course of treatment, should prompt a thorough diagnostic evaluation and appropriate treatment. Signs or symptoms of progressive multifocal leukoencephalopathy (focal neurologic deficits, which may present as hemiparesis, visual field deficits, cognitive impairment, aphasia, ataxia, and/or cranial nerve deficits). If PML is suspected, obtain brain MRI scan and lumbar puncture.
Pregnancy Risk Factor
Pregnancy Considerations
Animal reproduction studies have demonstrated adverse effects including decreased (reversible) B-cells and immunosuppression. Rituximab crosses the placenta and can be detected in the newborn. In one infant born at 41 weeks gestation, in utero exposure occurred from week 16-37; rituximab concentrations were higher in the neonate at birth (32,095 ng/mL) than the mother (9750 ng/mL) and still measurable at 18 weeks of age (700 ng/mL infant; 500 ng/mL mother) (Friedrichs, 2006).
B-cell lymphocytopenia lasting <6 months may occur in exposed infants. Limited information is available following maternal use of rituximab for the treatment of lymphomas and hematologic disorders (Ton, 2011). Retrospective case reports of inadvertent pregnancy during rituximab treatment collected by the manufacturer (often combined with concomitant teratogenic therapies) describe premature births and infant hematologic abnormalities and infections; no specific pattern of birth defects has been observed (limited data) (Chakravarty, 2010). Use is not recommended to treat non-life-threatening maternal conditions (eg, rheumatoid arthritis) during pregnancy (Makol, 2011; Østensen, 2008) and other agents are preferred for treating lupus nephritis in pregnant women (Hahn, 2012).
Effective contraception should be used during and for 12 months following treatment. Healthcare providers are encouraged to enroll women with rheumatoid arthritis exposed to rituximab during pregnancy in the MotherToBabyAutoImmune Diseases Study by contacting the Organization of Teratology Information Specialists (OTIS) (877-311-8972).
Patient Education
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Patient may experience abdominal pain, diarrhea, rhinorrhea, muscle spasms, back pain, insomnia, or night sweats. Have patient report immediately to prescriber signs of infection, signs of progressive multifocal leukoencephalopathy (confusion, depression, trouble with memory, behavioral changes, change in strength on one side, trouble speaking, change in balance, vision changes), signs of Stevens-Johnson syndrome/toxic epidermal necrolysis (red, swollen, blistered, or peeling skin [with or without fever]; red or irritated eyes; or sores in mouth, throat, nose, or eyes), signs of liver problems (dark urine, feeling tired, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes), signs of kidney problems (urinary retention, blood in urine, change in amount of urine passed, weight gain), signs of bowel problems (black, tarry, or bloody stools; fever; mucus in stools; vomiting; vomiting blood; severe abdominal pain; constipation; diarrhea), angina, tachycardia, arrhythmia, severe dizziness, passing out, loss of strength and energy, severe headache, severe nausea, vomiting, bruising, bleeding, shortness of breath, excessive weight gain, swelling of arms or legs, severe muscle pain, severe joint pain, burning or numbness feeling, or signs of tumor lysis syndrome (fast heartbeat or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; nausea, vomiting, diarrhea or lack of appetite; or feeling sluggish) (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.
More about rituximab
Consumer resources
Professional resources
- Other brands: Rituxan


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HOME MLB Oakland Athletics Gear Oakland Athletics Mens Oakland Athletics Mens Hats Oakland Athletics Mens Hats Mens (216 items) Product ID: 1834628
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Cheer on your Oakland Athletics with this Flair Hair visor! Turn some heads on game day when you rock this fun novelty visor, the perfect way to spread some Oakland Athletics team spirit! With its crazy and colorful "hair" accents and bright embroidered Oakland Athletics graphics, this classic visor will make any fan smile!
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The Village of Swallowfeld (PFRPG)
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Bugs, Sunset and S'mores
search for bugs around the preserve (bug nets provided), hike to the highest mound and view the sunset, finally roast marshmallows for s'mores. registration required.
Date: This event ended on
Cost: Non-members $7.
Venue: Tifft Nature Preserve.
1200 Fuhrmann Blvd.
1200 Fuhrmann Blvd.
More Info: www.sciencebuff.org/tifft-nature-preserve | 825-6397.


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Many people are talking about how the United States lost the space race after all. But forget meaningless national boundaries, sadly it looks like humanity is losing a much more crucial race: the race to make space a commodity before the oil runs out.
Robin LutherShared publicly -
A great show for Washington, but a heartbreaking end of the line for Discovery.
I grew up watching this fly, its the stuff dreams are made of.
I grew up watching this fly, its the stuff dreams are made of.
As the shuttle Discovery flew past Washington's Lincoln Memorial, watchers reflected on the end of an era in space travel.
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I'm with you on the PBMP. Here's the homework... Name three governor's and two senators that would do Uncle Teddy proud!
Expanding the route that averages three driver's licenses per household... Land Rover, Mercedes and a trick Honda, ha! Ride the #4, habla ingles? ...or whatever they speak in Slovenia. Ask your friend's wife, her cousins might be indentured with you. I know you counter-bloodlines have been raging against the "nobility" out of eastern Europe for centuries. Please take your money and ego to the Cayman's. This is sacred land where you golf.
This is a once in a lifetime opportunity to crack the two party system. Undecided plus "neither of the main candidates" totals 21.5 . Plus Big Johnson's 5 percent is more than Hillary's got, this poll was taken before she was found to be lying about her poor health. The two-party(more like one!) system will inexorably entrench after being blindsided by "the Donald". Two things are clear... We have to hit the establishment with both barrels and we have to do it NOW while they are in disarray. The other thing, the sad thing, is Trump is exactly what brainwashed, xenophobic morons recognize, respect and deserve. The track record of the oracular powers of EPC voters are made clear enough to embarrass anybody foolhardy enough to pay for a poll. hehe!
Smooth move Anschutz! Now let your slaves possess their own passports!
Let's break Ray's comments down line by line…
"Most of these so-called bikers are a menace to the public."
Most is a tricky word, is it really most cyclist or maybe just the ones that you noticed and can still remember. Do you remember every cyclist you saw who was not being a menace?
"It is time to force bikers to be licensed, carry liability insurance,"
Licensed? So at what age would you like kids to start taking a test to ride their bike? Most cyclists also have a car and also then have a license and insurance. Cyclists also don't need a license to be ticketed by police for breaking traffic laws.
"and to pay road taxes like the rest of do."
Road taxes don't even pay for most of the road. Property, income and sales tax (think 2C) make up a larger portion of the funding. Plus, the large majority of cyclists own cars. They also pay the exact same taxes even when they are riding their bicycle which has the added benefit of greatly reducing the wear and tear on those roads (less potholes for everyone)
"I've seen bikers----the large majority"
What did we say about using the word majority…
"run stop signs, weave in and out of traffic"
Some cyclists break traffic laws, and they should be ticketed for, so do cars and every road user every day. Cyclist do not break traffic laws in a greater quantity just because they are cyclist (you just happen to remember them more). And no, the sample size of only the cyclist you remember doesn't count.
"kick cars for no reason other than spite, so on and so forth."
Let's hope they stub their toe…that's just rude no matter what type of transportation you choose.
Dogs are only as vicious as they are trained and treated. Treat them well and train them well and they are good animals. Treat them cruelly and train them to kill....they will.
Mary Ann Redfern and others like her need to get their heads out of the poop bag they are in......NO DOG IS VICIOUS....it is all HOW THEY ARE TREATED AND TRAINED. Even a poodle can be trained as a KILLER!
He never worked with me, one of his constituents when he was my city councilman. Never anwered an email. So why would he work "across the ailse".
This is a total waste of tax payer resources. Instead do something to help people get off the street NOT shuffle them elsewhere.
For a reality check, the writer of this article should have interviewed downtown employees and residents. As a downtown resident of many years, I object to the characterization that we downtowners do not want to share the public space. I think we are very welcoming to people who show common courtesy and obey simple, common sense rules. Class and race have nothing to do with it. This article seems like a national narrative that's imposed on Colorado Springs, rather than a focused view of what our downtown is really like.
Thanks Gavin for sharing. #music from the heart.
I am curious, what sort of authority does a private security force have? If they are just private citizens, can the public just ignore their commands, or have they been granted some sort of authority by the city? Seems like the city should clarify, who, what and why these patrols exist, and exactly what authority they have.
Maybe because "preaching" is self righteously telling others how to live? Dictating how others live their lives is creepy. Going against the will of the voters who voted for legalizing marijuana is counter to democracy and creepy in a totalitarian, dictatorial kind of way. Calling people twits is just childish and lacks originality.
So why do the creepy pot smoking twits at the Indy feel the need to use the word "preaches?"
he should NOT receive a pension, gun or badge and should be locked up
IGNORANCE! ABUSE will change all living creatures. Pit Bulls are no different than any other animal. Horses are known to be violent and have had to be put down. Other dog breeds have also been violent and have been put down.
IT IS USUALLY THE OWNER! An owner needs to educate themselves before taking on a pet. ANY PET. Are you expecting to board a horse in an apartment? Do you have the time to devote to your pet? It takes time and effort to socialize a pet. Is your home appropriate for the pet? Is it calm or in chaos? Wll the pet fit in with other pets you may have? Can you afford the pet, food, vaccines, vets, etc.? Do you have adequate housing for you pet?
BEWARE OF THE WARNINGS? Don't put a fox in a chicken coup? Be aware of consequences. A baby cannot defend itself against animals. THINK! FIND YOUR COMMON SENSE.
I speak from experience. I own 3 pits bulls. I live alone on an acre of land with several acres between neighbors. I don't have any children visiting. I am usually home 24/7.
I am applauded by the animal control dept in my area. I am more afraid of someone killing my dogs because they are pits then I am of them biting someone. They have never been mistreated by a human and they trust people.
dogs arnt bad animals ANY OF THEM the dog will respond to how it is treated period. as for the officer? those igits arnt allowed on my property AT ALL...EVER!! most of em dont know what they are doing. and the dogs know it. alot of them dont even like animals. AND THE DOGS KNOW IT. as for pits they are sweet and awesome IF you are a dog lover. if your not a dog lover maybe you should choose another type of pet ...maybe a turtle.
Another example of horizontal growth not being able to pay for itself long-term. Too much area to patrol, tax base can't cover the costs.
Pitiful. The city has entered YOYO territory, i.e., You're On Your Own.
Meanwhile, the Mayor runs off to AZ, telling them not to legalize MJ.
Is there a "bathroom bill" due soon from our enlightened leadership?
Major companies are beating down the doors to move here. NOT!!
Most of these so-called bikers are a menace to the public.
It is time to force bikers to be licensed, carry liability insurance, and to pay road taxes like the rest of do.
I've seen bikers----the large majority---run stop signs, weave in and out of traffic, kick cars for no reason other than spite, so on and so forth.


text: On Thu, Feb 26, 2009 at 03:26:34PM +0100, Pritesh Kothari wrote: > Hi, > > As mentioned in the earlier mail, I have started the work on > adding Virtualbox support to libvirt. I have completed almost > all the basic functionality. Currently I can start, shutdown, > reboot, list and suspend/resume the domains. > > Now I am in the process writing code for creating/defining the domains > and thats where i need some help. I am not familiar with the exact XML format > required. I have gone through the docs at http://libvirt.org/formatdomain.html > as well as the code and have few question regarding the same as below: > > Is the XML format for defining the Domains common to all the hypervisors? If > not then how should I start about defining it for Virtualbox? The XML format has always been intended to be the same across drivers. A few releases ago, we introduced generic internal API for parsing the domain XML format, to guarentee that all drivers use the same format. You can see the APIs to use in src/domain_conf.h, and the schema in docs/schemas/. That said, we need to do some additions for VirtualBox eventually, depending on just what configs it supports. So if you find things you need that are not yet covered by our domain XML schema, post details to the list and we can figure out the best way to represent them. > What exactly does the tag <os_type>xen</os_type> exactly mean? how can xen, > hvm, etc be an os type? This tag refers to the ABI of the guest kernel - hvm : unmodified bare metal OS - ie FullyVirtualized - xen: xen 3.0 paravirt ABI VirtualBox is a fullyvirt technology, so I expect you'll only want to support 'hvm' as an os type. You declare what architectures, and SO types you support when creating your capabilities data - virCapabilityPtr - see src/capabities.h > why virDomainCreate doesn't actually create the domain but it just starts it? > (virDomainCreateXML actually creates it) virDomainCreateXML() spawns an unmanaged guest, with no config file. For a managed guest, virDomainDefineXML() writes the config file, and virDomainCreate() launches a guest from that config. > The rest of my question are more general and not related to XML def. > > In src/qemu_driver.c:qemudGetVersion() why does the qemu driver have to take > the lock, i mean what can change while extracting the version info? is there > any specific reason? (this is true for other drivers like openvz, uml, etc as > well ) As of 0.6.0, the libvirtd daemon is fully multi-threaded. This means that many API calls can be using your driver concurrently. So every driver API call you have (ie those registered in the 'virDriver' struct must use one or more mutexs to ensure safe access to internal state. > > I am using dlopen() and friends to open the VirtualBox library at runtime, is > it ok? cause I didn't see any driver doing something like this. I think it depends on exactly how you are doing it - best to just post the patches and we can discuss whether it looks reasonable then. Why did you dlopen() instead of just linking to it directly ? Regards, Daniel -- |: Red Hat, Engineering, London -o- http://people.redhat.com/berrange/ :| |: http://libvirt.org -o- http://virt-manager.org -o- http://ovirt.org :| |: http://autobuild.org -o- http://search.cpan.org/~danberr/ :| |: GnuPG: 7D3B9505 -o- F3C9 553F A1DA 4AC2 5648 23C1 B3DF F742 7D3B 9505 :|


text:
Public forum on stun gun use setMarch 05,2013The Vermont attorney generals office will hold a public forum next week to evaluate police use of stun guns.
The forum to be held next Monday in Montpelier will include a panel made up of two lawmakers, the heads of the Vermont American Civil Liberties Union and Disability Rights Vermont and Vermont Attorney General Bill Sorrell. Members of the public will also be invited to provide comments.
Several presentations will be given on the current training and policies on the use of stun guns and the risk and benefits of using them.
After the forum, the panel will make recommendations to the attorney general on police use of the devices.
The forum will be held on March 11 at 10 a.m. in the auditorium of the Pavilion building.MORE IN Vermont NewsMONTPELIER More than 2,000 young adults might have wrongly stayed on the states health... Full StoryIf this hasnt been the worst year ever for truth in politics, I cant think of what was. Full StoryMONTPELIER Renowned poet and playwright David Budbill died early Sunday morning from... Full Story
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In this movie we'll prepare and export the final animated GIF file. Now the first thing that we need to is set up this animation so that it repeats endlessly, and you do that by dropping down to this item that says Once in the bottom left corner of the Timeline panel. Go ahead and click on it, and choose Forever, and that way this animation will repeat over and over again. And to test it, you can either go ahead and click on that Play button down here at the bottom of the panel, or you can press the space bar.
And as soon as it makes its entire loop, right there it's going to go ahead and replay. Now, assuming that everything looks good, and you're not having any stumbling blocks, you can go ahead and tap that space bar again in order to stop the playback and now what you want to do is return to the very first frame, whether by scrolling to it and clicking on it, or you can click on the select first frame icon. Then we'll go ahead and scroll all the way to the end of the animation and Shift + click on it. And notice this duration interval right here that's set to zero seconds, go ahead and click on any one of them It's going to affect every single frame, and you want to choose Other.
And the idea here is that if you don't set some sort of delay, which serves as a kind of frame rate, then it'll play differently inside of every browser on the planet. So what we're looking for is a delay that equates to 24 frames per second, and if you get a calculator and you divide the number one, just enter one, hit divide, and then hit 24, you'll end up with this value right here, 0.04, and so that's what we want for the delay. You'll end up with the value of 0.04.
So go ahead and enter that value into the set delay field and then click okay, and you'll see that value represented at the bottom of each and every frame. All right, now, you want to go up to the file menu and choose the Save for Web command. In order to bring up the Safe for Web dialogue box, as soon as you can, make sure that the file format is set to GIF. You also want to set the second option to selective, you want the number of colors to be maxed out to 256, and you want to change the dither algorithm from diffusion as by default to noise, which is going to give you a lot better result.
Now, I've already set things up in advance, so I'll just go ahead and click off this option in order to hide it. You can have transparency turned on or off. I actually recommend that you go ahead and turn that check box off in order to get the smallest results possible. And that's going to require Photoshop to go ahead and recalculate all the frames. Now, if you'd like to go ahead and preview the effect, you can click on the play button here inside the dialogue box, and that'll give you a sense for whether things are playing back smoothly, and it'll show any weird, sort of, anomalies that are happening inside that GIF file.
But, in my case, everything looks great. So, I'll go ahead and click the stop button, in order to stop the playback, and then I'll click on the save button, in order to save off my animation. And I am going to go ahead and change the name of this file to one that I have copied in advance, which is ball travels around impossible triangle, and that way we have a detailed and discoverable name in the event that we post this file to the web. And now to save the file, I'll go ahead and click on this save button, and it will take a moment to generate every single one of those 252 frames.
But you'll know Photoshop has done its thing as soon as it hides the Save for Web dialog box. And now, lets take a look at what Photoshop's come up with by switching over to the folder that contains this new file, and then I'll go ahead and click on it to select it, and I'll right click, on the file and I'm working from the standard Windows Explorer here on the PC. On the Mac you would be looking at a finder folder. And now go ahead and choose open with and I'm going to open this GIF file with Google Chrome, but you can choose any browser that you like and if you're not seeing the application you want, then you can choose the default program.
But in my case we're going to switch to Chrome as we're seeing here. And that friends is how you use Photoshop to export a mind bending animated optical illusion to a smooth playing GIF file.
- Creating an "impossible" triangle with hexagons and gradients
- Drawing and filling the golden ball
- Drawing the path of the ball
- Creating frames as layers
- Animating your artwork in Photoshop


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In Brief: Ukraine launches offensive to retake Donetsk
Ukraine launches effort to retake Donetsk
DONETSK, Ukraine -- Ukrainian officials said their forces advanced to the outskirts of a key town north of Donetsk on Saturday as they try to retake the stronghold held for months by pro-Russia rebels.
The move comes as Ukrainian forces appear to have gained some momentum recently by retaking control of territory from the rebels. But Russia also appears to be becoming more involved in the fighting, with the U.S. and Ukraine accusing Moscow of moving heavy artillery.
Ukrainian national security spokesman Andriy Lysenko said Ukrainian forces were outside Horlivka, just north of the regional center of Donetsk.
Once they can take Horlivka, "the direct route is open for the forces of the anti-terrorist operation to the capital of the Donbass region -- the city of Donetsk," Lysenko said. "The approaches to Donetsk are being blocked so that the terrorists do not get the chance to receive ammunition."
Dutch: First victim identified from flight
THE HAGUE, Netherlands -- The Dutch government said the first victim has been identified from the Malaysia Airlines Flight 17 disaster.
The name and sex of the victim, a Dutch national, weren't released. The government said Saturday the next of kin and mayor of the victim's hometown have been informed.
More than 200 forensic experts are working at a military barracks in the central city of Hilversum to identify bodies and human remains recovered from the wreckage of the jet.
Russia: EU weakens anti-terrorism efforts
MOSCOW -- Russia lashed out Saturday at the latest round of Ukraine-related sanctions imposed by the European Union, saying they endanger the fight against international terrorism.
The EU sanctions impose travel bans and asset freezes on 15 people, including the head of Russia's Federal Security Service and the head of the agency's department overseeing international operations.
-- from wire reports