text: Jon Gosselin Plus Date -- a Lohan!! 1 7/23/2009 2:50 AM PDT BY TMZ STAFF Jon Gosselin's GF Hailey Glassman may be trouble, but she's nothing compared to his date last night in the Hamptons -- Michael Lohan.The Ugly Truth: Nothing like two guys bonding over the exploitation of their kids. See Also Jon & Kate Plus AWKWARD Jon Gosselin Rolls Back Into Town

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Organizations from the New England Patriots to small municipalities are tapping mobility as a foundational technology for improving customer experience.
HP Inc. CTO Shane Wall weighs in on three big macro trends that are shaping the company's long-horizon strategy.
CTO Brian Morgan at platform startup Catalant lets the business be his lodestar for shaping IT investments. Open source software and AWS help too.
Moving servers off premises to a colocation facility can be a daunting task. Use these best practices to minimize downtime to ensure a seamless transition.
Virtual machines can now run on the edge, near the things at the center of the internet of things, making use of multiple applications outside the data center.
Learn how to use Btrfs snapshots with Linux utilities, such as Snapper and GRUB2, to revert back to previous states in the event of a configuration mishap.
The latest IEEE Ethernet standard gets more life out of CAT5e and CAT6 cables by raising bandwidth from 1 Gbps to as much as 5 Gbps.
ICYMI: Talari survey studies the cost of network outages, ARM introduces a chip interconnect system and a study indicates that phishing attacks are taking aim at system files.
This week, bloggers look into ExtraHop continuous packet capture, Oracle's cloud computing goals and the breach at Yahoo.
Expert Dan Sullivan examines the HawkEye AP platform, a big data security analytics product from Hexis Cyber Solutions that can parse hundreds of different data formats.
Citing a long list of transgressions, Mozilla prepares to sanction Chinese certificate authority WoSign by removing it from its list of trusted certificate issuers.
The Yahoo breach was the largest in history and the fallout is widespread, including a lawsuit, possible SEC investigation and questions about Yahoo's breach detection and response.
Two heads are better than one, but sharing one computer can be tricky. Expert Yvette Francino explains how pair programming can make for better-quality code.
It's tempting to think software testers just need technical chops. Of course they do, but that's not all. Columnist Jennifer Lent explains what else you might need.
It is easy to make mistakes when implementing DevOps. Expert Bert Jan Schrijver explains the right way to use automation, testing and DevOps support teams.
Virtual Instruments taps into expertise gained through the Load DynamiX merger to teach its VirtualWisdom analytics products to monitor NAS, along with Fibre Channel SAN arrays.
NetApp all-flash arrays and hybrid storage arrays get updates, along with the ONTAP operating system and added support for Microsoft Azure, to kick off its annual technical conference.
As NAS technology changes -- with new software features and faster, all-flash NAS hardware -- its use in organizations has evolved into functions for which it was never suited.


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Most Cited Fitoterapia Articles
The most cited articles published since 2011, extracted from Scopus.
Antioxidant and prooxidant properties of flavonoidsD. Procházková | I. Boušová | N. Wilhelmová
Volume 82, Issue 4, June 2011, Pages 513-523
The interest in possible health benefits of flavonoids has increased owing to their potent antioxidant and free radical scavenging activities observed in vitro. Nevertheless, the antioxidant efficacy of flavonoids in vivo is less documented and their prooxidant properties have been actually described in vivo. Due to their prooxidant properties, they are able to cause oxidative damage by reacting with various biomolecules, such as lipids, proteins and DNA. Hence, the aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids. © 2011 Elsevier B.V. All rights reserved.
Synergy research: Approaching a new generation of phytopharmaceuticalsHildebert Wagner
Volume 82, Issue 1, January 2011, Pages 34-37
The longstanding, successful use of herbal drug combinations in traditional medicine demands that we find a rationale for their comparative pharmacological and therapeutic superiority to isolated single constituents. The synergistic efficacy of these combinations can be evaluated and verified by Berenbaum's isobole method, followed by clinical studies performed in comparison with synthetic standard drugs. There are many examples of mono- and multi-extract combinations used presently, which exhibit synergistic efficiency based on multi-target mechanisms of action. Among the natural products, gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs. The main targets were found to be COX 1 + 2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family. © 2010 Elsevier Inc. All rights reserved.
Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathyAmit D. Kandhare | Kiran S. Raygude | Pinaki Ghosh | Arvindkumar E. Ghule | Subhash L. Bodhankar
Volume 83, Issue 4, June 2012, Pages 650-659
Diabetes mellitus is a serious debilitating epidemic affecting all social strata in developing as well as developed countries. Diabetic neuropathy is most common of secondary complications associated with diabetes mellitus and is characterized by slowing of nerve conduction velocity, elevated pain, sensory loss and nerve fiber degeneration. The aim of the present investigation was to evaluate the neuroprotective effect of naringin against streptozotocin (STZ) induced diabetic neuropathic pain in laboratory rats. Four weeks after intraperitoneal injection of STZ resulted in significant decrease in mechano-tactile allodynia, mechanical hyperalgesia, thermal hyperalgesia and motor nerve conduction velocity. Activity of endogenous antioxidant like superoxide dismutase as well as membrane bound inorganic phosphate enzyme was also found to be significantly decreased. It not only caused neural cell apoptosis but also enhanced lipid peroxide, nitrite, and inflammatory mediators' (TNF-α) level. Chronic treatment with naringin (40 and 80 mg/kg) for 4 weeks significantly and dose dependently attenuated the decrease in level of nociceptive threshold, endogenous antioxidant and membrane bound inorganic phosphate enzyme. It also decreased the elevated levels of oxidative-nitrosative stress, inflammatory mediators as well as apoptosis in neural cells significantly and dose dependently. The important finding of the study is that, the naringin-insulin combination not only attenuated the diabetic condition but also reversed the neuropathic pain, whereas insulin or naringin alone only improved hyperglycemia but partially reversed the pain response in diabetic rats. Thus, naringin is a potential flavonone bearing antioxidant, antiapoptotic and disease modifying property acting via modulation of endogenous biomarker to inhibit diabetes induced neuropathic pain. © 2012 Elsevier B.V. All rights reserved.
Enzyme-assistant extraction (EAE) of bioactive components: A useful approach for recovery of industrially important metabolites from seaweeds: A reviewW. A J P Wijesinghe | You Jin Jeon
Volume 83, Issue 1, January 2012, Pages 6-12
Over the years, the biological activities of seaweeds could have gained a considerable research interest because of their specific functional compounds, which may not be available in land plants. Thus, efforts at discovery of novel metabolites from seaweeds over the past years have yielded a considerable amount of new active compounds. In addition, studies about the extraction of active compounds from natural products have attracted special attention in the last recent years. Potent biologically active compounds of seaweeds have been demonstrated to play a significant role in prevention of certain degenerative diseases such as cancer, inflammation, arthritis, diabetes and hypertension. Therefore, seaweed derived active components, whose immense biochemical diversity looks like to become a rich source of novel chemical entities for the use as functional ingredients in many industrial applications such as functional foods, pharmaceuticals and cosmeceuticals. Thus, the interest in the extraction of active compounds from seaweeds is obvious. However, the physical and chemical barriers of the plant material become the key drawbacks of such extraction process. Therefore, enhanced release and recovery of active compounds attached to the cells have been addressed. Taken together, the aim of this communication is to discuss the potential use of enzyme treatment as a tool to improve the extraction efficiency of bioactive compounds from seaweeds. Crown Copyright © 2011 Published by Elsevier B.V. All rights reserved.
The intestinal microbiome: A separate organ inside the body with the metabolic potential to influence the bioactivity of botanicalsSam Possemiers | Selin Bolca | Willy Verstraete | Arne Heyerick
Volume 82, Issue 1, January 2011, Pages 53-66
For many years, it was believed that the main function of the large intestine was the resorption of water and salt and the facilitated disposal of waste materials. However, this task definition was far from complete, as it did not consider the activity of the microbial content of the large intestine. Nowadays it is clear that the complex microbial ecosystem in our intestines should be considered as a separate organ within the body, with a metabolic capacity which exceeds the liver with a factor 100. The intestinal microbiome is therefore closely involved in the first-pass metabolism of dietary compounds. This is especially true for botanical supplements, which are now marketed for various health applications. Being of natural origin, their structural building blocks, such as polyphenols, are often highly recognized by the human and especially the intestinal microbial metabolism machinery. Intensive metabolism results in often low circulating levels of the original products, with the consequence that final health effects of botanicals are often related to specific active metabolites which are produced in the body rather than being related to the product's original composition. Understanding how such metabolic processes contribute to the in situ exposure is therefore crucial for the proper interpretation of biological responses. A multidisciplinary approach, characterizing the food and phytochemical intake as well as the metabolic potency of the gut microbiota, while measuring biomarkers of both exposure and response in target tissues, is therefore of critical importance. With polyphenol metabolism as example, this review describes how the incorporation of microbial metabolism as an important variable in the evaluation of the final bioactivity of botanicals strongly increases the relevance and predictive value of the outcome. Moreover, knowledge about intestinal processes may offer innovative strategies for targeted product development. © 2010 Elsevier Inc. All rights reserved.
An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituentsAihua Zhang | Hui Sun | Ye Yuan | Wenjun Sun | Guozheng Jiao | Xijun Wang
Volume 82, Issue 8, December 2011, Pages 1160-1168
6,7-Dimethylesculetin (D), geniposide (G) and rhein (R) are the three major active ingredients of Yin-Chen-Hao-Tang (YCHT), a famous Chinese herbal formula, which has been shown to be clinically effective for treating hepatic injury (HI) syndrome. The present study was conducted to investigate the therapeutic and synergistic effects of COC (combination of D, G and R) on HI rats by combining pharmacokinetic with biochemical analysis strategy. Plasma was analyzed by using reversed-phase high performance liquid chromatography (RP-HPLC). Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) models were built to evaluate the therapeutic and synergistic effects of COC at the biochemical level. Here, we report that the COC combination could increase the plasma level, slow elimination rate, exert a more robust therapeutic effect than any one or two of the three individual compounds by hitting multiple targets in a rat model of HI. Overall, this beneficially accounts for the popular view that traditional Chinese medicine (TCM) formula usually takes multi-component to exert their therapeutic effects. We suggest that dissecting the mode of action of clinically effective formula to be capable of producing a sufficient effect at low doses. © 2011 Elsevier B.V. All rights reserved.
Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal modelsYu Cui Li | Yan Fang Xian | Siu Po Ip | Zi Ren Su | Ji Yan Su | Jing Jin He | Qing Feng Xie | Xiao Ping Lai | Zhi Xiu Lin
Volume 82, Issue 8, December 2011, Pages 1295-1301
Pogostemonis Herba has long been used in traditional Chinese medicine for the treatment of inflammatory disorders. Patchouli alcohol (PA), a tricyclic sesquiterpene isolated from Pogostemonis Herba, is known to possess a variety of pharmacological activities. The present study aimed to investigate the in vivo anti-inflammatory effect of PA using two common inflammatory animal models i.e., xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. The degree of edema in both inflammatory animals, as well as the protein and mRNA expression of some inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), prostaglandin E 2 (PGE 2) and nitric oxide (NO) in the hind paw of carrageenan-treated rats were measured. Results showed that PA (10-40 mg/kg) significantly inhibited the ear edema induced by xylene in mice and the paw edema induced by carrageenan in rats. In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-α, IL-1β, PGE 2 and NO in the hind paw of carrageenan-treated rats. Furthermore, PA treatment also suppressed the mRNA expression of TNF-α, IL-1β, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats. These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-α, IL-1β, iNOS and COX-2. © 2011 Elsevier B.V. All rights reserved.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studiesVincenzo Mollace | Iolanda Sacco | Elzbieta Janda | Claudio Malara | Domenica Ventrice | Carmen Colica | Valeria Visalli | Saverio Muscoli | Salvatore Ragusa | Carolina Muscoli | Domenicantonio Rotiroti | Franco Romeo
Volume 82, Issue 3, April 2011, Pages 309-316
Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders. © 2010 Elsevier B.V. All rights reserved.
Therapeutic orchids: Traditional uses and recent advances - An overviewMohammad Musharof Hossain
Volume 82, Issue 2, March 2011, Pages 102-140
Orchids have been used as a source of medicine for millennia to treat different diseases and ailments including tuberculosis, paralysis, stomach disorders, chest pain, arthritis, syphilis, jaundice, cholera, acidity, eczema, tumour, piles, boils, inflammations, menstrual disorder, spermatorrhea, leucoderma, diahorrhea, muscular pain, blood dysentery, hepatitis, dyspepsia, bone fractures, rheumatism, asthma, malaria, earache, sexually transmitted diseases, wounds and sores. Besides, many orchidaceous preparations are used as emetic, purgative, aphrodisiac, vermifuge, bronchodilator, sex stimulator, contraceptive, cooling agent and remedies in scorpion sting and snake bite. Some of the preparations are supposed to have miraculous curative properties but rare scientific demonstration available which is a primary requirement for clinical implementations. Incredible diversity, high alkaloids and glycosides content, research on orchids is full of potential. Meanwhile, some novel compounds and drugs, both in phytochemical and pharmacological point of view have been reported from orchids. Linking of the indigenous knowledge to the modern research activities will help to discover new drugs much more effective than contemporary synthetic medicines. The present study reviews the traditional therapeutic uses of orchids with its recent advances in pharmacological investigations that would be a useful reference for plant drug researches, especially in orchids. © 2010 Elsevier B.V. All rights reserved.
Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.Eleonora S. Mengoni | Gabriel Vichera | Luciano A. Rigano | Marcelo L. Rodriguez-Puebla | Silvia R. Galliano | Eduardo E. Cafferata | Omar H. Pivetta | Sivia Moreno | Adrián A. Vojnov
Volume 82, Issue 3, April 2011, Pages 414-421
In the present study, we evaluated the effects of extracts and purified compounds from fresh leaves of Rosmarinus officinalis L. Pretreatment with the major anti-inflammatory compounds, carnosic acid (CA) and carnosol (CS), inhibited phorbol 12-myristate 13-acetate (PMA)-induced ear inflammation in mice with an EC50 of 10.20 μg/cm2 and 10.70 μg/cm 2, respectively. To further understand the anti-inflammatory mechanism of these compounds, we analyzed the in vivo expression of several inflammation-associated genes in mouse skin by reverse transcriptase-polymerase chain reaction (RT-PCR). Our data showed that CA and CS reduced the expression of IL-1β and TNF-α but had less effect on fibronectin and ICAM-1 expression. Interestingly, both compounds selectively inhibited COX-2 but not COX-1. Histopathological analysis of hematoxylin and eosin (H&E)-stained tissue revealed a marked reduction in leukocyte infiltration and epidermal ulceration of PMA-treated ears when ears were pretreated with ethanolic extracts or pure CA. In vitro, we showed that ethanolic extract, carnosic acid and carnosol significantly inhibited the overproduction of nitric oxide (NO) in a dose-dependent manner in the RAW 264.7 murine macrophage cell line. For the first time in vivo, we showed that CA and CS differentially regulate the expression of inflammation-associated genes, thus demonstrating the pharmacological basis for the anti-inflammatory properties reported for CA and CS. © 2010 Elsevier B.V. All rights reserved.
Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)Richard B. Van Breemen | Yi Tao | Wenkui Li
Volume 82, Issue 1, January 2011, Pages 38-43
Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC50 values of 32 μM, 17.5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger. © 2010 Elsevier Inc. All rights reserved.
Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cellsHong Ying Chen | Xiao Li Ye | Xue Long Cui | Kai He | Ya Nan Jin | Zhu Chen | Xue Gang Li
Volume 83, Issue 1, January 2012, Pages 67-73
Generally, berberine, coptisine, palmatine, and jatrorrhizine were considered as the main bio-active compounds in Rhizoma Coptis (RC). Little attention was paid to investigate the pharmacological activity of minor constituents in RC. The present study was designed to separate the minor compounds, and the cytotoxicity and antihyperglycemic effect of these compounds in HepG2 cells were also studied. Palmatine (1), berberine (2), coptisine (3), epiberberine (4), columbamine (5), and jatrorrhizine (6) from RC ethanol extract were isolated by high speed counter current chromatography (HSCCC) in one run. The remaining fraction (about 50% of extract in HSCCC) was further isolated by traditional column chromatography methods to yield magnoflorine (7), ferulic acid (8), and choline (9). Another four alkaloids, namely groenlandicine (10), berberrubine (11), oxyberberine (12), 8-oxo-coptisine (13), also were obtained from CHCl 3 extracts. Especially, choline was first isolated from RC. Cell assay indicated that the minor fractions excluding compounds 1-6 showed obvious glucose lowering activity. In addition, the minor monomers also exhibited moderate glucose lowering activity. The combination of berberine and ferulic acid showed synergistic effect on antihyperglycemic. The combination of alkaloids 1-6 was same so. All compounds had different cytotoxicity in HepG2 cells within the test concentration. Of them, berberrubine showed the strongest cytotoxicity. The results suggested that combined action of variety constituents contributed to the antihyperglycemic effets and low cytotoxicity of RC extract in HepG2 cells. Crown Copyright © 2011 Published by Elsevier B.V. All rights reserved.
Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: A comprehensive review of animal and human studiesAllison L. Hopkins | Marnie G. Lamm | Janet L. Funk | Cheryl Ritenbaugh
Volume 85, Issue 1, March 2013, Pages 84-94
The effectiveness of Hibiscus sabdariffa L. (HS) in the treatment of risk factors associated with cardiovascular disease is assessed in this review by taking a comprehensive approach to interpreting the randomized clinical trial (RCT) results in the context of the available ethnomedical, phytochemical, pharmacological, and safety and toxicity information. HS decoctions and infusions of calyxes, and on occasion leaves, are used in at least 10 countries worldwide in the treatment of hypertension and hyperlipidemia with no reported adverse events or side effects. HS extracts have a low degree of toxicity with a LD50 ranging from 2,000 to over 5,000 mg/kg/day. There is no evidence of hepatic or renal toxicity as the result of HS extract consumption, except for possible adverse hepatic effects at high doses. There is evidence that HS acts as a diuretic, however in most cases the extract did not significantly influence electrolyte levels. Animal studies have consistently shown that consumption of HS extract reduces blood pressure in a dose dependent manner. In RCTs, the daily consumption of a tea or extract produced from HS calyxes significantly lowered systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults with pre to moderate essential hypertension and type 2 diabetes. In addition, HS tea was as effective at lowering blood pressure as the commonly used blood pressure medication Captropril, but less effective than Lisinopril. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides were lowered in the majority of normolipidemic, hyperlipidemic, and diabetic animal models, whereas high-density lipoprotein cholesterol (HDL-C) was generally not affected by the consumption of HS extract. Over half of the RCTs showed that daily consumption of HS tea or extracts had favorable influence on lipid profiles including reduced total cholesterol, LDL-C, triglycerides, as well as increased HDL-C. Anthocyanins found in abundance in HS calyxes are generally considered the phytochemicals responsible for the antihypertensive and hypocholesterolemic effects, however evidence has also been provided for the role of polyphenols and hibiscus acid. A number of potential mechanisms have been proposed to explain the hypotensive and anticholesterol effects, but the most common explanation is the antioxidant effects of the anthocyanins inhibition of LDL-C oxidation, which impedes atherosclerosis, an important cardiovascular risk factor. This comprehensive body of evidence suggests that extracts of HS are promising as a treatment of hypertension and hyperlipidemia, however more high quality animal and human studies informed by actual therapeutic practices are needed to provide recommendations for use that have the potential for widespread public health benefit. © 2012 Elsevier B.V.
Determination of chemical profile, antioxidant, DNA damage protection and antiamoebic activities of Teucrium polium and Stachys ibericaBektas Tepe | Serpil Degerli | Serdal Arslan | Erdogan Malatyali | Cengiz Sarikurkcu
Volume 82, Issue 2, March 2011, Pages 237-246
This work deals with the evaluation of in vitro antioxidant, DNA preventing and antiamoebic activities of the water extracts of Teucrium polium and Stachys iberica. In all systems, T. polium extract exhibited excellent activity potential than that of S. iberica. The amount of total phenolics and flavonoids were high in this extract. In the presence of 40 mg/ml T. polium extract, a significant protection was observed for native super coiled DNA of pBR322 plasmid DNA. In the presence of 32 mg/ml of T. polium extract, no trophozoite was after the 24th hour. © 2010 Elsevier B.V.
Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanismsSeung Hong Lee | You Jin Jeon
Volume 86, Issue 1, April 2013, Pages 129-136
Marine algae are popular and abundant food ingredients mainly in Asian countries, and also well known for their health beneficial effects due to the presence of biologically active components. The marine algae have been studied for biologically active components and phlorotannins, marine polyphenols are among them. Among marine algae, brown algae have extensively studied for their potential anti-diabetic activities. Majority of the investigations on phlorotannins derived from brown algae have exhibited their various anti-diabetic mechanisms such as α-glucosidase and α-amylase inhibitory effect, glucose uptake effect in skeletal muscle, protein tyrosine phosphatase 1B (PTP 1B) enzyme inhibition, improvement of insulin sensitivity in type 2 diabetic db/db mice, and protective effect against diabetes complication. In this review, we have made an attempt to discuss the various anti-diabetic mechanisms associated with phlorotannins from brown algae that are confined to in vitro and in vivo. © 2013 Elsevier B.V. All rights reserved.
Synergy effects of herb extracts: Pharmacokinetics and pharmacodynamic basisYong Yang | Zaiqi Zhang | Shuping Li | Xiaoli Ye | Xuegang Li | Kai He
Volume 92, Issue , January 2014, Pages 133-147
Herbal medicine, especially traditional Chinese medicine and Ayurvedic medicine have played and still play an important role in fighting against various diseases. Emerging clinical studies regarding traditional Chinese medicine have provided convincing evidence for the first time to gain credibility and reputation outside China. Although synergistic therapeutic actions of herbal ingredients have been frequently reported, few reports have offered clear underlying mechanisms. This might be the main reason for the conflicting views with respect to the therapeutic efficacy of medicinal herbs. Therefore, this paper reviews the herb synergisms reported in the recent literature and discusses thoroughly the mechanisms underlying synergistic actions of herbal ingredients. The authors conducted an electronic literature search to detect articles published mainly in the last five years. Articles were included if they pertained to synergy research of ethnomedicines or the active compounds derived from them, included verification of synergy effects using modern analytical tools and molecular-biological methods. Results have revealed that the multi-component nature of medicinal herbs makes them particularly suitable for treating complex diseases and offers great potential for exhibiting synergistic actions. The mechanisms underlying synergistic therapeutic actions of herb medicines are (1): different agents may regulate either the same or different target in various pathways, and therefore cooperate in an agonistic, synergistic way; (2): regulate the enzymes and transporters that are involved in hepatic and intestinal metabolism to improve oral drug bioavailability; (3): overcome the drug resistance mechanisms of microbial and cancer cells; and (4): eliminate the adverse effects and enhance pharmacological potency of agents by "processing" or by drug-drug interaction. The exploration of synergistic mechanisms of herbal ingredients will not only help researchers to discover new phytomedicines or drug combinations but also help to avoid the possible negative synergy. Further clinical research is required for verifying these reported drug combinations and discovered synergistic mechanisms. © 2013 Elsevier B.V. All rights reserved.
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in ratsBahareh Amin | Hossein Hosseinzadeh
Volume 83, Issue 5, July 2012, Pages 888-895
The current study was designed to evaluate therapeutic potential of systemically administered ethanolic and aqueous extracts of saffron as well as its bioactive ingredients, safranal and crocin, in chronic constriction injury (CCI)-induced neuropathic pain in rats. The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i.e., one day before surgery and 3, 5, 7 and 10 days post surgery. The ambulatory behavior was evaluated using the open field test. A 7-day treatment with the ethanolic and aqueous extracts (50,100 and 200 mg/kg, i.p.) and safranal (0.025, 0.05 and 0.1 mg/kg, i.p.), attenuated the behavioral symptoms of neuropathic pain in a dose dependent manner. Crocin even at the high dose (50 mg/kg) failed to produce any protective role. However, gabapentine (100 mg/kg) as a reference drug significantly alleviated all behavioral manifestations of neuropathic pain compared to control group. In conclusion, the results of this study suggest that ethanolic and aqueous extracts of saffron as well as safranal could be useful in treatment of different kinds of neuropathic pains and as an adjuvant to conventional medicines. © 2012 Elsevier B.V. All rights reserved.
Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cellsGuo Sheng Wu | Jin Jian Lu | Jia Jie Guo | Ying Bo Li | Wen Tan | Yuan Ye Dang | Zhang Feng Zhong | Zeng Tao Xu | Xiu Ping Chen | Yi Tao Wang
Volume 83, Issue 2, March 2012, Pages 408-414
Ganoderic acid DM (GADM) is a triterpenoid isolated from Ganoderma lucidum, a well-known edible medicinal mushroom. In the present study, we found that GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. GADM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we also showed that GADM elicited DNA damage as measured by comet assay which is a sensitive method for DNA damage detection. γ-H2AX, a marker of DNA damage, was also slightly up-regulated after treated with GADM for 6 h, suggesting that the G1 cell cycle arrest and apoptosis induced by GADM may be partially resulted from GADM-induced DNA damage. These results have advanced our current understandings of the anti-cancer mechanisms of GADM. © 2011 Elsevier B.V. All rights reserve.
Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in ratsLan Yang | Cheng Zhang Wang | Jian Zhong Ye | Hai Tao Li
Volume 82, Issue 6, September 2011, Pages 834-840
The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale. © 2011 Elsevier B.V. All rights reserved.
The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological propertiesNizar Tlili | Walid Elfalleh | Ezzeddine Saadaoui | Abdelhamid Khaldi | Saida Triki | Nizar Nasri
Volume 82, Issue 2, March 2011, Pages 93-101
Caper (Capparis L.), a shrub plantwith a large natural distribution, is used in traditional medicines to cure various illnesses. Phytochemicals studies have shown the presence of many beneficial compounds such as spermidine, rutin, quercetin, kaempferol, stigmasterol, campesterol, tocopherols, and carotenoids. Biological studies reveal important antimicrobial, anti-oxidative, anti-inflammatory, immunomodulatory and antiviral properties. The presented review summarizes information concerning the morphology, ethnopharmacology, phytochemistry, and biological activities of caper plants. © 2010 Elsevier B.V. All rights reserved.
Investigation into the antioxidant activity and chemical composition of alcoholic extracts from defatted marigold (Tagetes erecta L.) residueYing Gong | Xuan Liu | Wen Hao He | Hong Gao Xu | Fang Yuan | Yan Xiang Gao
Volume 83, Issue 3, April 2012, Pages 481-489
The influence of various solvents on the yield of polyphenols from defatted marigold residue, the antioxidant activity of the extracts and the composition of antioxidant compounds in the extracts were investigated. The content of total phenolics and flavonoids in the extracts was significantly varied with different solvents (P < 0.05) and the extract by ethyl alcohol (EtOH)/water (7:3, v/v) has the highest content of total phenolics and flavonoids, 62.33 mg gallic acid equivalents (GAE)/g and 97.00 mg rutin equivalent (RE)/g, respectively. The antioxidant activity of the extracts was evaluated by radical (2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH)) scavenging and ferric reducing antioxidant power (FRAP) assays. The results of the correlation analysis showed that the antioxidant activity was well correlated with the content of total phenolics and flavonoids (R 2 > 0.900). Antioxidant components in the extracts were identified by combined on-line HPLC-ABTS + post-column assay and HPLC-DAD-MS method. Gallic acid, gallicin, quercetagetin, 6-hydroxykaempferol-O- hexoside, patuletin-O-hexoside and quercetin were the dominant antioxidant compounds in the extracts, and quercetagetin was identified as the strongest antioxidant capacity. © 2011 Elsevier B.V. All rights reserved.
Recent advances in herbal medicines treating Parkinson's diseaseXu Zhao Li | Shuai Nan Zhang | Shu Min Liu | Fang Lu
Volume 84, Issue 1, January 2013, Pages 273-285
Herbal medicines have attracted considerable attention in recent years, which are used to treat Parkinson's disease (PD) in China based on traditional Chinese medicine or modern pharmacological theories. We summarized and analyzed the anti-Parkinsonian activities of herbal medicines and herbal formulations investigated in PD models and provide future references for basic and clinical investigations. All the herbal medicines and herbal formulations were tested on PD models in vitro and in vivo. The relevant compounds and herbal extracts with anti-Parkinsonian activities were included and analyzed according to their genera or pharmacological activities. A total of 38 herbal medicines and 11 herbal formulations were analyzed. The relevant compounds, herbal extracts and formulations were reported to be effective on PD models by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD. The plant species of these herbal medicines belong to 24 genera and 18 families, such as Acanthopanax, Alpinia and Astragalus, etc. These herbal medicines can be an alternative and valuable source for anti-Parkinsonian drug discovery. The plant species in these genera and families may be the most promising candidates for further investigation and deserve further consideration in clinical trials. Active components in some of the herbal extracts and the compatibility law of herbal formulations remain to be further investigated. © 2012 Elsevier B.V.
Flavonol-rich fractions of yaupon holly leaves (Ilex vomitoria, Aquifoliaceae) induce microRNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofribroblast CCD-18Co cellsGiuliana D. Noratto | Youngmok Kim | Stephen T. Talcott | Susanne U. Mertens-Talcott
Volume 82, Issue 4, June 2011, Pages 557-569
Polyphenolics extracted from yaupon holly (Ilex vomitoria, Aquifoliaceae) (YH) leaves were investigated in human colon cells for their chemopreventive and anti-inflammatory activities. An activity-guided fractionation allowed the selection of YH flavonol-rich fraction due to its preferential inhibition of HT-29 colon cancer viability over the normal CCD-18Co colon cells. Quercetin and kaempferol 3-rutinosides, main components identified in this fraction, protected CCD-18Co cells against reactive oxidative species (ROS) in part due to increased activity of antioxidant enzymes. In addition, up-regulation of microRNA-146a (miR-146a) known as a negative regulator of pro-inflammatory NF-κB activation was the underlying molecular mechanism that protected CCD-18Co from inflammation. © 2011 Elsevier B.V. All rights reserved.
(-)-α-Bisabolol attenuates visceral nociception and inflammation in miceGerlânia De O. Leite | Laura H I Leite | Renata De S. Sampaio | Mariana Késsia A Araruna | Irwin Rose A De Menezes | José Galberto M Da Costa | Adriana R. Campos
Volume 82, Issue 2, March 2011, Pages 208-211
The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (-)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent. © 2010 Elsevier B.V. All rights reserved.
Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh gingerFang Peng | Qiaofeng Tao | Xiumei Wu | Hui Dou | Shawn Spencer | Chaoyong Mang | Lu Xu | Lianli Sun | Yu Zhao | Haibo Li | Su Zeng | Guangming Liu | Xiaojiang Hao
Volume 83, Issue 3, April 2012, Pages 568-585
Twenty-nine phenolic compounds were isolated from the root bark of fresh (Yunnan) ginger and their structures fully characterized. Selected compounds were divided into structural categories and twelve compounds subjected to in-vitro assays including DPPH radical scavenging, xanthine-oxidase inhibition, monoamine oxidase inhibition, rat-brain homogenate lipid peroxidation, and rat pheochromocytoma PC12 cell and primary liver cell viability to determine their antioxidant and cytoprotective properties. Isolated compounds were also tested against nine human tumor cell lines to characterize anticancer potency. Several diarylheptanoids and epoxidic diarylheptanoids were effective DPPH radical scavengers and moderately effective at inhibiting xanthine oxidase. An enone-dione analog of 6-shogaol (compound 2) was isolated and identified to be most effective at protecting PC12 cells from H 2O 2-induced damage. Almost all tested compounds inhibited lipid peroxidation. Three compounds, 6-shogaol, 10-gingerol and an enone-diarylheptanoid analog of curcumin (compound 6) were identified to be cytotoxic in cell lines tested, with KB and HL60 cells most susceptible to 6-shogaol and the curcumin analog with IC 50 < 10 μM. QSAR analysis revealed cytotoxicity was related to compound lipophilicity and chemical reactivity. In conclusion, we observed distinct compounds in fresh ginger to have biological activities relevant in diseases associated with reactive oxygen species. © 2012 Elsevier B.V. All rights reserved.


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Rise Against, Killswitch Engage + letlive Add November Leg to 2015 Tour
Get ready for Leg 2! Rise Against, Killswitch Engage and letlive will continue touring together this fall.
Get ready for Leg 2! Rise Against, Killswitch Engage and letlive will continue touring together this fall.
Rise Against will hit the road with Killswitch Engage and letlive this summer.
Five Finger Death Punch, Rise Against and Slash are just a few of the rockers leading the way at the 2015 Beale Street Music Festival in Memphis.
Linkin Park's 'The Hunting Party' tour will last one month and will cover some parts of North America that weren't hit by the band's recent 'Carnivores' tour.
Organizers of the 2014 Riot Fest in Denver have moved the event to Sports Authority Field after being denied a permit at Byers' May Farms.
Foo Fighters, Slayer and Rise Against are among the rock acts leading the lineup for the 2014 Voodoo Experience in New Orleans.
Following the recent announcement of the Toronto lineup, the organizers of Riot Fest have now unveiled the list of bands performing at the Chicago and Denver editions of the festivals, as well. While there are a great deal of alt-rock acts, there are a number of heavy hitters on the bills.
Rise Against recently unleashed their B-sides and rarities collection, 'Long Forgotten Songs,' and we've got a couple of cool items for fans related to the release. One is the album sampler video above and the other is an awesome contest featuring a 'Lost Forgotten Songs' prize pack.
The launch trailer for EA Sports 'NHL 14' features the rousing Dropkick Murphys tune 'The Boys Are Back,' and it's a fitting track considering the hockey's struggles with the lockout as well as the band's longtime love for the game. The song, which is featured on the group's last album 'Signed and Sealed in Blood,' isn't the only interesting addition to the 'NHL 14' soundtrack.
The track listing for the Tony Sly tribute album has been released and it reads like a roll call of the elite of punk rock. The record, 'The Songs of Tony Sly: A Tribute,' is a 26-track compilation honoring the late No Use for A Name singer, who died on July 31, 2012 at the age of 41. All proceeds will benefit the Tony Sly Memorial Fund, which was established for Sly's widow Brigitte and their daughters.


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Home > Sunglasses > Tom Ford > CELINA (FT0361 - 01A)
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These sunglasses complement your look with an accessory that is a cut above the rest. True to the Edel-Optics motto "SEE AND BE SEEN", you are on a par with celebrities, impressing in every environment. Would another colour not be a better match for your favourite outfit? Check also the other styles of FT0361in our 2015, and 2016 Tom Ford range.
This frame was specially designed for genuine power women. Graceful design and expressiveness are interspersed with classical chic. Eyewear is in. Full rim is extremely popular, because you feel that you get more eyeglass for your money. It is not just about their resilience, but also about the visibility of material and design, which are of the highest quality. The square shape accentuates the face shape, making it the perfect style element for self-confident personalities. Plastic frames like these combine durability and are comfortable to wear. The FT0361 is a very snug fit on the ears and nose. Black eyeglasses are a must-have. They can be combined with anything and refine any style. Whether at your desk, in a club or at a fashion show - black always fits. The fact that the colour grey matches everything, also applies to sunglass lenses. They suit everything in your wardrobe and never go out of fashion. You can rely on the guaranteed UV400 protection, for all the sunglasses in our shop.
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A guy steps on home plate.
The crowd doesn't like that guy.
They shout "BOO".
The crowd doesn't like that guy.
They shout "BOO".
"Boo, you stink a lot you bad player."
লিখেছেন- medium bro 3 de ডিসেম্বার de 2006
Sound that a fake ghost would make
লিখেছেন- BEYONCE 8 de নভেম্বার de 2003
Never ever gonna get butt love. Not even if there's a fire.
You: Hey how bout some bf later?
Me: booooo
Never gonna have it.
Me: booooo
Never gonna have it.
লিখেছেন- Beefy one 28 de সেপ্টেমবার de 2013
the incorrect spelling for the word Beau. most commonly used by people who have heard the word but do not know how to spell it. beau meaning: boyfriend or girlfriend. boo meaning: what a ghost says.
went out with my beau last night.
the ghost screamed boo
the ghost screamed boo
লিখেছেন- chitownpaul 12 de অক্টোবার de 2011
a word you yell at someone who keeps staring at you.
Boo!!What are you looking ugly.
লিখেছেন- Drucilla Coleman 20 de জুন de 2007
A word used to scare people.
Guy: "BOO!"
Guy2: "omgwtfbbq"
Guy2: "omgwtfbbq"
লিখেছেন- Gracin 11 de জুলাই de 2005
A word used to scare a person
Person 1: BOOOO!!!
Person 2: AHHH!!!
Person 2: AHHH!!!
লিখেছেন- Reagan Lausche 21 de ফেব্রুয়ারি de 2005


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Complete her crowning moment with this Sequin Trimmed Custom White Sash!
Our sparkling Sequin Trimmed Custom White Sash is trimmed with your choice of sequin colors, and embroidery fonts. Each custom Sequin Trimmed Custom White Sash measures 4 inches wide x 72 inches long. The Sequin Trimmed Custom White Sash is ideal for pageants, festivals, school events and more.
Please allow ample time for delivery. Our ship date for this product is noted in your shopping cart. Many items are shipped separately, so please allow extra time for these items to arrive. Shipping charges are based on the value of the merchandise and not the number of shipments. For additional shipping information, please contact our Customer Service Department at (firstname.lastname@example.com or 1-800-314-8794).
Reviewed by 2 customers
Best Uses
Loved the personalized sashes with sequins trim--the best-looking and most affordable quality sash for our Great Gatsby themed Prom.
Best Uses
this was for my grand Marshal


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Fox dumping 'Rake's' final 2 episodes on Saturday
Fox dumping "Rake's" final 2 episodes on Saturday
The low-rated Greg Kinnear drama will get a quiet sendoff this weekend.
Josh Radnor responds to "HIMYM" backlash and says a "really important scene" was cut
"I thought it was a really important scene," he says of a scene involving Ted and Robin. As for the backlash, he says, "I thought the title of the show was always a bit of a fake-out. It was more of a hook to hang the thing on. Really it was more about these are the crazy adventures and these are the lessons I had to learn before I met your mother."
Netflix adds "Sizzling Bacon" and "Rotisserie Chicken" to its lineup
Jon Hamm created the 20-minute video of bacon cooking for April Fool's Day. "Rotisserie Chicken," meanwhile, runs 70 minutes in reverse.
Demian Bichir's brother will join him on "The Bridge"
Bruno Bichir will play a wealthy Mexican business leader who becomes connected to his brother's character.
DirecTV orders its 1st original comedy series
"Things You Shouldn't Say Past Midnight" will focus on a variety of L.A. relationships after 12 a.m.
"Game of Thrones" gets the "Honest Trailer" treatment
Watch the hilarious NSFW Screen Junkies take on the HBO series.
"60 Minutes" blames an "audio error" for adding sound to a quiet Tesla electric car
The error made the Tesla sound as loud as a motorcycle.
Netflix orders Pablo Escobar drama "Narcos"
The 10-episode series will offer a a serialized take on Pablo Escobar and the Medellin Cartel.
"Teen Mom" Farrah Abraham becomes an erotic novelist
She has signed on to write a trilogy of books, starting with "Celebrity Sex Tape: In the Making."
Watch the trailer for the Aaron McGruder-less "Boondocks"
The Adult Swim series returns for its final season on April 21.


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|Women, Men, Girls, Boys, Infant/Baby
I have been knitting and crocheting for 60 years, having learned at the age of 5. After retiring in 2011, I am able to pursue my dream of designing my own patterns and sharing them.View all patterns by designer (159) »
Less than 3 ounces of the Super Bulky Yarn, was used for the Baby size. It makes for a Quick Knit Hat that you can complete in just a couple of leisurely hours.
Hat Pattern is written for
Newborn Head Circumference: 9" - 11"
Baby - to Toddler Head Circumference: 17" - 19"
Child 3-10 years old Head Circumference: 20" - 21"
Adult Head Circumference: 22" - 24"
2 sts, 3 rows =1"


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AT&T Inc. joined the recession's parade of layoffs Thursday by announcing plans to cut 12,000 jobs, about 4 percent of its work force.
The Dallas-based telecommunications company - the largest in the U.S. - said the job cuts will take place in December and throughout 2009. The company also plans to reduce capital spending next year. These layoffs come on top of 4,600 jobs the company said in April it would eliminate.
© 2016. All Rights Reserved. | Contact Us


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Jennifer Lawrence - Page 6
Did Jennifer Lawrence Fake Her 2014 Oscar Fall?
It's already a given that we have "fallen" in love with Jennifer Lawrence. But how real are her falls? You know, the ones where her feet get tangled and she eats it, which happened at last night's Oscars.
Jennifer Lawrence Tries to Steal Lupita Nyong'o's Oscar [PHOTO]
She may already have an Oscar to her name, but is looks like Jennifer Lawrence really wanted that Best Supporting Actress win!
The Best Oscar Moments You May Have Missed: Jennifer Lawrence Trips, Travolta Trips Up and More
The 2014 Oscars were loooong. In fact, we can't be entirely sure that they're not still going on somewhere. So, you can't be blamed if you took a pee break, got up to get some snacks and/or dozed off and missed something. It's OK, we got your back. In case you missed anything, we have a full list of all the Oscar winners, plus this quick handy wrap-up of all the other fun moments you may have missed.
Jennifer Lawrence Falls Again At The Oscars[VIDEO]
Her middle name must be Grace.
Jennifer Lawrences Sizzles in Red Peplum Dior Dress at 2014 Oscars [PHOTOS]
America's girl crush, Jennifer Lawrence, once again wore tomato red to the Oscars!
Jennifer Lawrence Falls on 2014 Oscars Red Carpet
Jennifer Lawrence's 2014 Oscars dress may be a throwback to her 2011 gown, but her red carpet walk channeled last year's awards.
Jennifer Lawrence, Zac Efron, Emma Watson + More to Present At 2014 Oscars
We already know that the 2014 Oscars are going to be brimming with A-list celebs -- but the star-wattage just increased with the announcement of the full list of presenters.
Jennifer Lawrence Taking a Year-Long Break
In a move that should upset Katniss Everdeen fans and those who harbor serious girl crushes on Jennifer Lawrence, the actress, who has barely had a second to breathe since her career caught fire (!), is reportedly taking a much-needed, totally deserved year-long break.
Jennifer Lawrence Stuns With Minimal Makeup in Spring 2014 Dior Ads [PHOTOS]
The girl crush of all girl crushes -- yes, we mean Jennifer Lawrence -- is the face of Dior, the designer she wears on nearly every red carpet. The actress absolutely stuns in her latest campaign, which is for the spring 2014 season, wearing minimal makeup and showing off her new, short 'do.


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Washington, DC–(ENEWSPF)–November 25, 2012. The Department of Defense announced today the death of a sailor who was supporting Operation Enduring Freedom.
Petty Officer 1st Class Kevin R. Ebbert, 32, of Arcata, Calif., died Nov. 24 while supporting stability operations in Uruzgan Province, Afghanistan. Ebbert was assigned to an East Coast-based Naval Special Warfare unit in Virginia Beach, Va.
Source: defense.gov


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Welcome to the Law and Society Institute Berlin
The Berlin Law and Society Institute (LSI) is the Humboldt University's centre for interdisciplinary socio-legal studies. The Institute aims to integrate the long tradition of German Sociology of Law with the international Law and Society research, and to supplement doctrinal legal thinking with the systematic inclusion of social science and the humanities.
This website is under construction. We are looking forward to your visit when the website is launched.
Law and Society Institute Berlin
Prof. Dr. Susanne Baer, LLM.
Juristische Fakultät
Humboldt-Universität zu Berlin
Bebelplatz 1
10117 Berlin
Tel: +49 30 2093 3451
Fax: +49 30 2093 3431
Email: lsi (at) rewi . hu-berlin . de


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The reality starlet normally sports super long locks, but she decided to change up her look with a new, shorter 'do! Check out Kim's before and after!
Kim Kardashian, 31, loves to try different things when it comes to her beauty looks and it seems the gorgeous star has taken her strands up a few notches!
The Kardashian sisters are known for their lengthy locks, but Kim decided to make herself stand out by wearing her hair shorter. Regardless, she's always a cut above no matter how she wears her hair!
HollywoodLifers, do YOU like Kim's shorter 'do? Vote below!
— Jenny Pickard
More Kardashian News:


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Former Brazil striker Romario finally scored what he said was the 1,000th goal of his career by converting a penalty in Vasco da Gama's 3-1 over Sport Recife in the Campeonato Brasileiro on Sunday.
Celebrations and interviews held up the match for 16 minutes after the 41-year-old Brazilian great sent Sport goalkeeper Magrao he wrong way,
Romario's tally includes goals scored in youth team, friendly and testimonial games, but doubts about his milestone failed to dampen the celebrations.
Romario was playing his first game in nearly six weeks. He failed to score in three matches, leaving him stuck on 999 at the conclusion of Vasco's campaign in the Rio state league and Copa Brasil. The sideshow surrounding Romario's bid for 1,000 goals touched off all kinds of controversy within the team, and Coach Renato Portaluppi was fired.


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Skip to comments.Congressman Billybob Sez: Sixteen Little Words
Posted on 07/18/2003 6:07:08 PM PDT by Congressman Billybob
click here to read article
According to Heinrich Muller, chief of Gestapo and employed by the US intelligence after the war, Hitler escaped with Eva Braun, left the burned double behind in the bunker. Muller helped with flight via Switzerland. He also provided much material about communists to CIA.
I turned Fox off in disgust a few weeks ago, but happened to turn it on early this morning -- before the news about the devil's sons being killed -- and they were actually being somewhat apologetic about their constant harping on the deaths of U.S. soldiers in Iraq, saying that they would be dishonoring our troops' sacrifice if they didn't report it. The Baghdad reporter repeated the theme, and even listed a few "good things" that were going on before he launched into the latest casualty count.
It doesn't make up for Fox's doom and gloom herd mentality for the past month (and the fact that they really don't go looking for any positive stories) but it does indicate that viewers' complaints (and maybe a fall in viewership) is having some impact.
Logic and facts in a well reasoned argument cause liberals/democRATS/socialist anxiety. Off to the re-education camp for you.
Thank you!
Another brilliant Republican(motto: we could teach the French a thing or two about pre-emptive surrender!)analysis!
Best regards,
At best Fox is "fair and balanced", meaning no more conservative than liberal. But in fact if you take the standard of what is the best prediction of what will seem important in a hundred years from now, almost nothing "liberal" is likely to make muster. And if that's the situation with Fox, what is the situation with CBS!
Bump. The Future is now. Be afraid, be very afraid. The 'twofer' is coming again...
Hell, they have been playing at GOAL-LINE STAND ranges for the past three weeks.
No kidding! RAT George Tenet was the worst offender. Is there any possiblity he did this whole admission thing ... on his own (perhaps with encouragement from his old boss) ... without the Prez and his Brain Trust signing off? And once having done so, they are uncertain how to deal with him, so wedded to their bi-partisanship insanity as they are?
I am convinced that Hillary will be running in '04 now for sure, and that it was primarily due to this huge political blunder by GWB and his inner circle. He could have FIRED Tenet promptly. Showed some guts. I can't imagine that this crowd did it deliberately, as I sure don't think they would want to be up against the Clinton's head-on again. Even Limbaugh is making noises now reversing his prognostications, admitting the possibility of Hillary in '04.
I only hear Limbaugh in small bits and pieces, I know he recently called the W Presidency "Nixonian" not Reaganesque.
Reason Magazine or (Human Events?) gave Nixon demerits for his growth of Big Government including such gems as the EPA.
I don't think Conservatives will "get it" until they see the concertina wire and smell the cordite.
Insanity-it is not just for DemocRATs anymore!
Best regards,
Best regards,
The exact same thing can be said of the "Cold War." Who surrendered? What treaty was signed?
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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Give your guests a sweet treat with these Baby Girl Treasure Personalized Candy Bars!
Our exclusive Baby Girl Treasure Personalized Candy Bars are printed with your custom wording on an adorable pink and white design accented with precious pink flowers. Our Baby Girl Treasure Personalized Candy Bars come in four fabulous flavors - milk chocolate, milk chocolate crisp, dark chocolate and dark chocolate mint. The 1.5 ounce Baby Girl Treasure Personalized Candy Bars measure 5 1/4 inches long x 2 inches wide.
Do you love white chocolate or want a candy bar with nuts? That's not a problem, opt for our Baby Girl Treasure Personalized Candy Bar Wrappers. You supply the chocolate, and we'll supply you with a one-of-a-kind candy bar wrapper.
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Below is a article why it is haram but two of the most Major signs are they the non believers Glorify Jesus (isa) alayhis salam THIS IS MAJOR SHIRK ALLAH IS THE ONLY TO BE GLORIFIED, and when parents send their kids to pray to santa for gifts and helping relieving issues in the home (MAJOR SHIRK)
there is nothing beautiful about it just plain shirk........
there are haddiths that if you take part in haram you get a portion, if you take part in good you get a portion of.
We have two holidays Eid al fitr and eid al Adha anything outside it IS BIDA AND IN SOME CASES SHIRK
I am saddened to see our ummah falling into these traps subhan'Allah please pass this on to encourage your fellow sisters to stay away from these Bid'a and shirk please if you care for your ummah.....
Jazak'Allah khairon
Syaikh Muhammad bin Shalih al-Uthaymeen rahimahullah was asked:
What is the ruling regarding wishing "Merry Christmas" to them [the Christians]? What about giving them an answer when they wish us with the same? Is it permissible to go to the places of festive occasions or parties which celebrate this occasion? Is someone considered to have sinned when he does something related to the above without intending to do so [his real reason] yet he did it only to show respect to his friends, or out of shame, or other reasons? Is it possible to do so in these circumstances?
Praise be to God.
To wish the non-Muslims with Merry Christmas or any of their religious festivals is haraam (forbidden), by consensus of the ulama (ijma'), as Ibn al-Qayyim, may God have mercy on him, said:
"Congratulating the kuffaar on the rituals that belong only to them is haraam by consensus, as is congratulating them on their festivals and fasts by saying "A happy festival to you" or "May you enjoy your festival", and so on. If the one who says this has been saved from kufr, it is still forbidden. It is like congratulating someone for prostrating to the cross, or even worse than that. It is as great a sin as congratulating someone for drinking wine, or murdering someone, or having illicit sexual relations, and so on.
Many of those who have no respect for their religion fall into this error; they do not realize the offensiveness of their actions. Whoever congratulates a person for his disobedience or bid'ah or kufr exposes himself to the wrath and anger of God."1
Congratulating the kuffaar on their religious festivals is haraam to the extent described by Ibn al-Qayyim because it implies that one accepts or approves of their rituals of kufr, even if one would not accept those things for oneself. But the Muslim should not accept the rituals of kufr or congratulate anyone else for them, because God does not accept any of that at all, as He says (interpretation of the meaning):
"If you disbelieve, then verily, God is not in need of you, He likes not disbelief for His slaves. And if you are grateful (by being believers), He is pleased therewith for you. . ."2
"This day, I have perfected your religion for you, completed My favour upon you, and have chosen for you Islam as your religion…"3
So congratulating them is forbidden, whether they are one's colleagues at work or otherwise.
If they greet us on the occasion of their festivals, we should not respond, because these are not our festivals, and because they are not festivals which are acceptable to God. These festivals are innovations in their religions, and even those which may have been prescribed formerly have been abrogated by the religion of Islam, with which God sent Muhammad (P) to the whole of mankind.
God says (interpretation of the meaning):
"Whoever seeks a religion other than Islam, it will never be accepted of him, and in the Hereafter he will be one of the losers."4
It is haraam for a Muslim to accept invitations on such occasions, because this is worse than congratulating them as it implies taking part in their celebrations.
Similarly, Muslims are forbidden to imitate the kuffaar by having parties on such occasions, or exchanging gifts, or giving out sweets or food, or taking time off work, etc., because the Prophet (P) said:
"Whoever imitates a people is one of them."
Shaykh al-Islaam Ibn Taymiyah said:
"Imitating them in some of their festivals implies that one is pleased with their false beliefs and practices, and gives them the hope that they may have the opportunity to humiliate and mislead the weak."5
Whoever does anything of this sort is a sinner, whether he does it out of politeness or to be friendly, or because he is too shy to refuse, or for whatever other reason, because this is hypocrisy in Islam, and because it makes the kuffaar feel proud of their religion.
God is the One Whom we ask to make the Muslims feel proud of their religion, to help them adhere steadfastly to it, and to make them victorious over their enemies, for He is the Strong and Omnipotent.
Taken from Majmu Fatwa Fadllah al-Syaikh Muhammad bin Shalih al-Uthaymeen, Vol. III, pp. 44-46, no.403
Ahkaam Ahl al-Dhimmah [back]
Qur'an, 39:7 [back]
Qur'an, 5:3 [back]
Qur'an, 3:85 [back]
Ibn Taymiyyah, Iqtidaa' al-siraat al-mustaqeem mukhaalifat ashaab al-jaheem [back]
Asalamu Alaikum, Shokran, for sharing. I am a fairly new convert. This post is very educational.
wa'alaykum asalam rahmatullah wa barakatuh sister anagalia011...i am so sorry i am just seeing this i almost never log in anymore due to work schedules and 3 kids mashaAllah..I am really happy it has helped you, I am a shahada myself....There is a wonderful group on here called Muslim Moms if u are not a member its a wonderful group to ask questions as well...If I can I really try to log on a little more then i usually do....if you have anyquestions please feel free to message me as well i will try to log in once a week inshaAllah ...
Already a member? Click here to log in
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Description: First two pages of the interior of the Hotel Sherman wine list, with a woodcut of a man in a top hat, suit coat, and trousers, lying supine on the ground,...
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Date: 1904 ca.
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Advueu V800XPT Crusoe 800MHz / 802.11b Wireless / 8.4-inch SVGA / 256MB DDR / 20GB HDD / Built-in CCD PC Camera / Windows XP Tablet Edition / Tablet PCItem#:� T299-2000 �|�Model#:�V800XPT
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A coalition of Chester County groups will host a "Gun Buy Back" day Saturday at the Coatesville Memorial Community Center.
The event is a "no-hassle, no-questions-asked, no-arrests-made" opportunity to turn in firearms, organizers say.
Participants will receive a $100 gift card per gun and will be paid for a maximum of two guns, receiving a total maximum payment of $200 in gift cards. Additional guns may be turned in, but no payment will be received.
The event is an effort to combat gun-related violence in the community, said Chaya Scott, director of the Coatesville Youth Initiative which has a gun buy back program as part of their mission.


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COLTON, Calif. — A-Z Bus Sales Inc. has secured an award from the Los Angeles Unified School District (LAUSD) to replace old diesel buses with new compressed natural gas (CNG) Blue Bird buses.
Delivery of the new buses to LAUSD is anticipated in October and November of this year.
"LAUSD Transportation Department, with its long-term commitment to clean fuel-powered school buses, worked closely with the South Coast Air Quality Management District, school bus vendors and its school board to replace 20-plus-year-old diesel buses with clean burning CNG-powered school buses that will reduce air pollution, particulate matter and provide cleaner air for its students and the residents of Los Angeles," A-Z President Jim Reynolds said.
A-Z and Blue Bird have a long history with LAUSD. For more than 15 years, they have provided LAUSD with transit CNG buses as well as conventional propane-fueled buses.
A-Z delivered more than 235 propane buses to LAUSD and four of its contracted service providers in the past year.
Related Topics: alternative fuels, Blue Bird Corp.
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welcome to the barton group homepage! the barton group is a boutique accounting and business consulting firm specializing in in tax and general business consulting headquartered in Bozeman, MT and practicing throughout the United States. we provide services to closely-held entities, women owned business, high net worth individuals, expats, and software companies.we are committed to providing outstanding client service while delivering the best product utilizing our highly technical experience.
Price is what you pay. Value is what you get.Warren Buffett


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Su questo annuncio
Uno spazio in cui gli ospiti possono cucinare
Riscaldamento centralizzato o stufa elettrica nell'alloggio
Pagato o Gratuito nell'edificio
Hello and welcome to my hotel apartment!
Enjoy a classic Copenhagen apartment in a central historic location, just minutes from Tivoli Gardens, "Rådhuspladsen" and Strøget - our famous pedestrian shopping street. The location offers easy access to a range of choices for dinning, shopping, theatre and entertainment options.
NYBRO26 apartment hotel provide a two bedrooms with either two single beds or one double bed in each, and a sofa bed in the living room can accommodate up to 6 people. The rest of the apartment consists of a bathroom with shower, a fully-equipped kitchenette, and a living room with a large dining table. The launderette is placed next to the entrence and is only used by a few people living in the building. The apartment is on 3rd. floor. Towels and linen are included
NYBRO26 apartment hotel is situated in the heart of the city - just 15 minutes within driving distance to Copenhagen Airport and 5 minutes walk from the Central Station or Metro trains.
You enter NYBRO26 apartment hotel from the canal and the apartment is facing both Magstræde and a charming courtyard.
77 Recensioni
Il tuo Host
Hi and thank you for chooing my profile! My name is Andreas and I live in Copenhagen, I look forward welcoming you to my home.


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Feminism in Nepal
From Wikipedia, the free encyclopedia
|This article does not cite any sources. (February 2013) (Learn how and when to remove this template message)
Feminism in Nepal is primarily concerned with equity and equality of opportunity. Nepali society is traditionally highly patriarchal—it was not until 2007 that women under 35 could apply for passports without their father's or husband's permission—and feminists in Nepal seeks to redress this situation. Most women in Nepal are considered to be beneath their husbands and fathers in a patriarchal society.
Statistics from Violence Against Women, a website dedicated to raising awareness as well as finding solutions to present day issues, highlight these inequalities:
- 77 percent of the episodes of violence against women are reported as being from within the family
- 22 percent of women aged 15 to 49 have experienced physical violence at least once since age 15
- 43 percent of women have experienced sexual harassment in the workplace.
- Between 5,000 and 12,000 girls and women are trafficked every year. 75 percent of them are below 18 years of age and the majority are sold into forced prostitution.[2]
The first feminist organization in Nepal was the Nepal Woman Association started under the leadership of Mangala Devi Singh.
- After the lobbying of various organisations and feminist groups, 33% seats are reserved in every committee and group starting from the grass root level up to the legislative of Nepal.
- Government grants subsidy on tax while registering property in the name of women to improve the access of women on property.
- Women are allocating and reserving 33% seats on every possible programs fromm scholarship to government jobs to increase the participation of women.
- ABC Nepal is a non governmental, non profit organisation based in Kathmandu with regional offices in Bhairahawa and Biratnagar. It has been working since 1987 to empower women, raise the status of women through gainful employment opportunity, vocational training and leadership development in women. It has its focus on anti trafficking campaigns.
- Maiti Nepal
- Sancharika Samuha
- Shakti Samuha
- Women LEAD is a non-governmental organization based in Kathmandu that provides women's leadership development training and advocacy in Nepal.
|This Nepal-related article is a stub. You can help Wikipedia by expanding it.
|This feminism-related article is a stub. You can help Wikipedia by expanding it.


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More From GCeleb
Trending Headlines
- Angelina Jolie's Next Movie Sounds Exciting, Get The Details - Cinema Blend
- Hugh Hefner Laughs Off Rumors That He's Gravely Ill - E! Online
- Trump under fire after sending nasty tweets about 'disgusting' ex-Miss Universe - Washington Post
- Brad Pitt & Angelina Jolie Divorce Update: Watch to Find Out All the Details on Their New Agreement - E! Online
- Rob Kardashian Clears the Air After a 'Miscommunication' Caused Major Drama with Kylie Jenner - People Magazine
- Blake Lively and Ryan Reynolds Welcome Second Child - People Magazine
- 'Birth of a Nation' Nate Parker revisits sex-assault case on '60 Minutes' - USA TODAY


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A stroll around a pond in winter reveals an intricate tapestry of ice and grass. The effects of wind, thawing and re-freezing give rise to complex patterns and textures. -- Jim Rathert
Editor - Tom Cwynar
Managing Editor - Bryan Hendricks
Art Director - Ara Clark
Designer - Les Fortenberry
Designer - Patrick Kipp
Artist - Dave Besenger
Artist - Mark Raithel
Photographer - Jim Rathert
Photographer - Cliff White
Staff Writer - Jim Low
Staff Writer - Joan McKee
Composition - Libby Block
Circulation - Laura Scheuler


text:
micoach is all you need to get the results you want.
You will receive a confirmation to
(2 Products)
Your SelectionClear All
Love these TechFit fitted shirts. This is my fourth one. Lightweight and the fit is great for training. Not baggy and not too tight. Material is super smooth and comfortable. And you can't beat Adidas's prices for their gear. Other big name companies don't have any better quality and charge way more. ... read more
Overall I like the shirt. Only wish it wouldn't ride up when I run. I have the base tights too and the shirt always rides up so I have to constantly pull it back down during a run. A thin strip of clear rubber around the bottom might solve the problem! ... read more
highly recommended it to everyone. I purchased a XL but it kinda tight for me then i decided to going up to XXL and then the XXL is perfect fit, comfortable except for the back length of the shrit is slightly short so i dont know it suppose to be like that or what but whatever. ... read more
I bought the techfit base tee in size small color black. The size small fits true to size. The sleeve length runs slightly past my elbow. The fabric is light weight and offers compression. I washed this shirt several times and the color did not fade. I recommend hang drying. Overall, this shirt is well made with exceptional fabric and designed to offer a performance and flattering fit. ... read more
The heather, grey-ish color pictured is not this color at all - it is lime green as the small, greyed out description says. And dear customer service, just own the fact this is a mistake rather than saying the website photo may be slightly different than what arrives. Thank you. ... read more


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Enjoy quality B & B accommodation in Huonville, Southern Tasmania
The only Bed and Breakfast in Huonville, with the officially recognised "Accredited Tourism Business of Australia" seal of approval "Tick", so you can enjoy piece of mind in a quality approved bed and breakfast accommodation.
As the most inexpensively priced Bed & Breakfast in Huonville, Huon Valley Bed and Breakfast offers exceptional quality accommodation in a tranquil, restored period homestead, set in private grounds of 4.5 acres, with over an acre of delightful, park-like gardens.
Huon Valley Bed and Breakfast is situated on a gently sloping hillside overlooking the Huon River, with idyllic 360 degree views of Sleeping Beauty Mountain Range and the Huon Valley. Located just 1 km from the centre of Huonville, where you will find every amenity, including shops, restaurants, banks, etc, for your convenience.
Explore the Huon Valley
Huon Valley Bed and Breakfast is an ideal base for exploring Tasmania's wonderful Huon Valley, with nearby attractions including -
Or relax right here
You may well decide that total relaxation is what you need, in which case you need not leave Glenbriar Homestead. You are welcome to spend your day strolling the gardens or admiring the views. You can watch the abundant bird life (binoculars and guide book provided); amongst the many bird species in the area, you will see Fairy Wrens at play and the magnificent Wedge Tail and Sea Eagles soaring the thermals.
Perhaps you might like to just relax and contemplate the majestic old evergreen Magnolia tree (flowering late December to March), where it is reputed the famous American author, Mark Twain, once rested on his travels in Tasmania. For your interest there is a basket of "finds" on the verandah for you to ponder over. These items have all been picked up during the last few years of renovations to the property.
And you are welcome to explore the property. In its time it has seen eras as a farm, a commercial orchard, a private home, and now our home and B & B business.
The house and gardens have been sympathetically restored for this purpose and we invite you to share its delights with us. We know you will love it as we do.


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Company Overview of Legent Corporation
Company Overview
Legent Corporation develops and markets software for the management of information systems. The company's products are used to manage mainframe, midrange, server, workstation, and PC systems deployed throughout a business enterprise. It is based in Herndon, Virginia. As of August 1, 1995, Legent Corporation operates as a subsidiary of CA, Inc.
575 Herndon Parkway
Herndon, VA 22070-5226
United States
Key Executives for Legent Corporation
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text:
'We Want To Welcome People': 19 Sworn In As Citizens In PittsburghNineteen people from thirteen countries gather at the Allegheny Department of Human Services Wednesday morning, to officially become Americans.
Little Italy Days Kicks Off With Food, Music And CultureThis is the 15th year for Little Italy Days in Bloomfield.
Pittsburgh International Airport Could See Reduction In SizeMajor changes could be coming to the Pittsburgh International Airport.
Democratic Candidates Clinton-Kaine Campaign Bus Tour Making Stop In PittsburghHillary Clinton and her running mate, Sen. Tim Kaine, are wasting no time in bringing their campaign to blue-collar voters in western Pennsylvania.
Local Leaders Working To Improve Community-Police Relations With GatheringsWith violence exploding in other cities across the United States, local leaders are working to keep everyone safe and improve police-community relations.
Officials: 5 Officers Dead, 7 Hurt In Dallas Protest ShootingAn Army veteran killed by Dallas police after the sniper slayings of five officers amassed a personal arsenal at his suburban home, including bomb-making materials, bulletproof vests, rifles, ammunition and a journal of combat tactics, authorities said Friday.
Pittsburgh To Begin Using 'Life-Saving' Smartphone AppThe city and county want to improve the area's life-saving abilities with a smartphone app.
Orlando Victims Honored At Pittsburgh Pride Equality MarchIt was a day to celebrate cultural diversity and inclusion.
Black & Gold Day Declared In Pittsburgh As Penguins Prepare For Game 2The Pittsburgh Penguins are looking to take a 2-0 lead in the Stanley Cup Final tonight against the San Jose Sharks.
Allegheny Co. & Santa Clara Co. Place Wager On Stanley Cup FinalGame on, San Jose Sharks.
North Shore Development Leaving Few Available ParcelsThe focus of a Monday meeting between Steelers executives and local officials at Heinz Field was development on the North Shore.
Allegheny County Leaders Approve Push For Minimum Wage Increase In Pa.Allegheny County Council members approved a push to raise the state minimum's wage to $10.15 an hour.


text: 277 WGUS83 KGRR 181400 FLSGRR FLOOD ADVISORY NATIONAL WEATHER SERVICE GRAND RAPIDS MI 1000 AM EDT SUN SEP 18 2016 ...The flood advisory continues for the following rivers in Southwest Lower Michigan... Sycamore Creek At Holt affecting Ingham County .Dry conditions are anticipated today through much of Monday. A frontal boundary will approach Lower Michigan late Monday evening, bringing showers and thunderstorms. A few storms may result in locally heavy rainfall, which is likely to be brief. Overall precipitation amounts are expected to remain light. Water rises on Sycamore Creek are slowing, signaling that rises are nearing their peak. Provided that lighter amount pan out near Holt Monday night, flooding concerns will remain low. The following forecast is based on observed and forecast 24 hour precipitation. PRECAUTIONARY/PREPAREDNESS ACTIONS... Safety message...Caution is urged when walking near riverbanks. A flood advisory means minor flooding is possible and rivers are forecast to exceed bankfull. If you are in the advisory area remain alert to possible flooding...or the possibility of the advisory being upgraded to a warning. report observed flooding to local emergency services or law enforcement and request they pass this information on to the National Weather Service. Stay tuned to further developments by listening to your local radio... television... or NOAA Weather Radio station for further information. && MIC065-190600- /O.CON.KGRR.FL.Y.0105.000000T0000Z-160919T0600Z/ /HHTM4.N.ER.000000T0000Z.000000T0000Z.000000T0000Z.OO/ 1000 AM EDT SUN SEP 18 2016 The Flood Advisory continues for the Sycamore Creek At Holt * until late tonight. * at 09 AM Sunday the stage was 6.0 feet. * Bankfull stage is 6.0 feet. * Flood stage is 8.0 feet. * Forecast, the river is nearing its crest today, it will begin to to fall late this afternoon. * Impact, at 6.0 feet...Flooding begins in low lying areas along the creek and at the Lansing Municipal Golf Course and Scott Woods Park. && LAT...LON 4271 8455 4268 8455 4264 8451 4264 8445 4268 8449 4271 8451 $$ jam


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Company plans to maintain the Tecmo brand
TOKYO — Game maker Square Enix has launched a friendly take-over bid for game developer Tecmo, offering to buy shares at 930 yen ($8.56) apiece, 30% over their latest asking price.
If Tecmo does not respond by Sept. 4 or rejects the bid, Square Enix says it will drop it. The company plans to maintain the Tecmo brand after any take-over.
At a Tokyo press conference on Friday, Square Enix prexy Yoichi Wada said that the Japanese game industry "had better join hands strongly to some degree to develop its (business) worldwide" as global competition in the game biz intensifies.
He said that Square Enix itself was formed of a merger in 2003 and had pursued "a united strategy for a long time."
Tecmo prexy Yoshimi Yasuda will resign Sept. 1, to be succeeded by chairman Yasuharu Kakihara, who will hold both posts.
Wada said that he had been meeting with Kakihara since May to discuss "working together as a group."
However, a lawsuit filed in June by Tomonobu Itagaki, developer of the hit Tecmo game "Dead or Alive," claiming unpaid bonuses and emotional distress had complicated matters, as had another suit filed by Tecmo employees for unpaid overtime wages.
"I'd become concerned about what would happen concerning what we had discussed so far," Wada said, explaining his decision to launch the take-over bid.
Now that Tecmo is in play other game companies, such as Capcom and Konami, may launch a bidding war.
Founded in 1967, Tecmo created hit games "Dead or Alive," "Ninja Gaiden" and "Tecmo Bowl."
Started in 1975, Square Enix is best known for its role-playing games "Final Fantasy," "Dragon Quest" and "Kingdom Hearts."


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INDIANAPOLIS — A state Senate committee last week passed legislation that would require school bus drivers to do end-of-route inspections.
"Indiana has seen a rising number of incidents of students being left behind because a few drivers are not taking the extra step to check their buses at the end of their routes," said Sen. Teresa Lubbers, author of the bill. "This is not acceptable, and I am hopeful this legislation will encourage drivers to take the extra step of walking to the back of the buses and making sure all students have reached their destination."
The bill would require a school or special-purpose bus operator to visually inspect each seat within the bus at the end of each trip. If an operator fails to do so, he or she could face a Class C infraction, which is punishable by a fine of up to $500.
Lubbers' legislation would also require the owner of a school bus or special-purpose bus to report an incident in which a passenger is left on a bus to the Indiana Department of Education no later than five working days after the incident occurred.
The bill will next move to the full Senate for further consideration. If enacted, it would take effect July 1.
Related Topics: post-trip child check
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text:
Home > Sunglasses > Roberto Cavalli > RC902S (01B)
RC 902S is available in 4 additional attractive styles
New Releases
Size and availability
Free outbound and return shipping
30-day money-back guarantee
Low prices
Free outbound and return shipping
30-day money-back guarantee
Low prices
RC902S/01B Ophthalmic Glasses
These sunglasses are the perfect accessory on the beach, on the way to the office or in the city. There is only one slight drawback: all the envious looks you will attract. The RC902S is available in the Edel-Optics online shop in other styles from Roberto Cavalli collections 2015 and 2016.
Expressive lines add character to the classical approach, making the glasses a must-have for women. Wearing full rim eyewear, you make it unmistakably clear that you are going the whole hog. The square frame is a classical shape, highlighting the straightforwardness of the personality. Plastic frames like these combine durability and are comfortable to wear. The RC902S is a very snug fit on the ears and nose. Black is one of the undisputed classics. It can be combined with any outfit and simultaneously radiates elegance and naturalness. Grey lenses are a classic in sunglasses. Their high degree of neutrality with regard to the field of view, makes them particularly suitable for everyday use. Functionally, you are, of course, on the safe side, too. With 100% UV eye protection, the sun can immediately start shining.
The model has already been ordered and will shortly be back in stock. If you order now, you will get the reduced price and once the goods arrive, we will send you your new Roberto Cavalli on the same day. If you buy at Edel-Optics you get the best price, because "in the sale" is our standard.
New Releases
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text:
Rigatoni Pasta Clipart
Rigatoni pasta, from "riga," meaning line: rigatoni means that with lines. This golden yellow piece of dried pasta, in gold and yellow, is a classic Italian ingredient, indispensable for delivering delicious sauces to the diner's palate.
dried pasta , rigatoni , noodles , primi piatti , pasta clip art , italian , pasta clipart , food , first courses , pastas
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