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Western Refining Inc. WNR +2.03% is planning to buy a controlling stake in Northern Tier Energy NTI +2.60% LP, said people familiar with the matter, as it seeks to capitalize on a rise in U.S. oil production.
Western Refining, based in El Paso, Texas, would buy a 38.7% stake in Northern Tier owned by private-equity firms TPG and Acon Investments Ltd. for roughly $775 million, the people said. As part of the deal, Western Refining would get 100% of the so-called general partner that controls Northern Tier, they said.
Assuming it doesn't fall apart at the last minute, the deal could be announced Tuesday, the people said.
It is unclear how much Western Refining is paying per ownership unit, or share, but it appears to be a discount to the current market price of Northern Tier, which is based in Ridgefield, Conn. Northern Tier rose 2.6% to $23.26 in New York Stock Exchange trading Monday.
Buying Northern Tier would hand Western Refining a St. Paul Park, Minn., refinery located near the prolific Bakken Shale deposit in North Dakota. Increased production there and elsewhere has put downward pressure on U.S. oil prices, in turn increasing margins for local refiners—who buy crude and turn it into products such as gasoline. Western Refining also owns facilities near the Permian Basin in Texas and New Mexico.
Northern Tier is structured as a so-called master-limited partnership, a dividend-paying investment vehicle that enjoys special tax breaks and is often used by natural-resource companies.
The company also operates a chain of gasoline stations in Minnesota and Wisconsin. TPG and Acon bought the company from Marathon Oil Corp. MRO -0.27% for around $600 million in 2010 and took it public in 2012.
TPG has been active in the energy sector this year, striking deals including the $3.2 billion sale of Copano Energy LLC to Kinder Morgan Energy Partners KMP -0.16% LP. Returns on energy deals for the big private-equity firm have improved of late after its disastrous megabuyout of what was then known as TXU Corp. in 2007.
TPG teamed with KKR KKR -1.50% & Co. and Goldman Sachs Group Inc. GS +0.41% 's private-equity arm to buy TXU, now called Energy Future Holdings Corp., for $32 billion and about $13 billion in assumed debt. Falling natural-gas prices caused the Dallas-based power company to bleed cash and it is now negotiating with creditors on plans for a bankruptcy-protection filing


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Today is September 30, 2016 -
Lekh Lekha 5763
Posted on March 23, 2011
by Josh Dorsch
This week's parasha, Lech Lecha, deals with the beginning of the 10 tests that God gives to Abraham, all of which he passes with flying colors. In last weeks parasha, Abraham is put into a furnace because he wouldn't denounce his beliefs of God. And wouldn't you know it, he came out of it unharmed. This week, our portion begins with God telling Abraham:
"Lech l'cha me artzecha umemoladetche u me beit avicha el ha aretz asher arekha" (Go for you from your land and from your birthplace and from the house of your father to the land that I will show you).
This is the second of 10 tests which God puts Abraham through. However, being that God is all knowing, he would already know that Abraham would pass the tests. Why would he then require for Abraham to act them out? The Ohr Gedalia explains the situation to us, with "potential." He says that everyone is born with a certain amount of potential. G-D knows what everyone's potential is, however, it is our job reach for our potential. God may know exactly what someone is capable of doing, as well as what they should do, however, unless that person does it, he will remain the same. God knows you can talk, but you must walk the walk. Another way in which this dilemma can be viewed, is the ever so popular and controversial question, about Free choice. If God is supposed all knowing, and he knew what Abraham would choose, was Abraham actually tested in the first place? Rambam's answer to this question, is that God controls, and knows everything, except for how much one fears God. The reason in which someone would, or would not do something is because they are scared of their possible punishment. The more someone feared God, the more one would be inclined to follow God's commandments. Even though God may have known what Abraham was going to do, he decided to let Abraham see for himself. God bestowed upon Abraham a great responsibility. He was going to be the father of not only the Jewish People, but a lot of other nations as well. Abraham may have been unsure of him self to be able to handle such a big responsibility. These tests were not actually meant to show God how affirm to God that Abraham was the right man for the job. But, to show Abraham his potential to be the father of a great nation.

subset: commoncrawl


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Add a touch of sparkle and shine to any ensemble with the Naturalizer Farah. This women's sandal features metal hardware embellishments and an adjustable strap ensures a snug fit. The N5 Comfort System offers cushioned comfort, while a durable synthetic outsole lends long-lasting wear and reliable traction. Style yourself in the comfort and beauty of the Naturalizer Farah.
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Central got off to a roaring start Wednesday at the Public League Track and Field Championships at Johnston Stadium in Mount Airy.
The Lancers won four of the first six finals contested on Day 1.
Walt Pegues claimed two championships. He leaped 22 feet, 7 inches to capture the long jump, and he won the triple jump with a mark of 43-21/2.
Sam Reid won the discus with a throw of 151-10, and Jonathon Henderson took gold in the javelin with a heave of 142-7.


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Quoc Hoa Hotel - Hanoi
This hotel has its own restaurant serving breakfast, lunch and dinner where you'll find a selection of items to try. Guests wishing to enjoy a drink will surely want to visit the bar/lounge.
A health club and a sauna are among the leisure facilities on offer. Guests can make use of the free WiFi.
Quoc Hoa Hotel - Hanoi
Hotel Info: 1-877-214-4288from $47
- Family Room
- Deluxe Room (Classic)
- Deluxe Room, 1 Double or 2 Single Beds
- Superior Room, 1 Double or 2 Single Beds
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 55 rooms
- This hotel is arranged over 9 floors
- 24-hour check-in
- Check-out time is 11:30 PM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Couples wishing to share a room must provide proof of marriage
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free WiFi and wired Internet access in rooms
- Airport shuttle (available on request) *
- Train station pickup *
- No parking
In the hotel
- Free buffet breakfast daily
- Restaurant
- Bar/lounge
- Coffee shop/café
- Snack bar/deli
- Room service (during limited hours)
- Free reception
- Coffee/tea in a common area
- Health club
- Steam room
- Sauna
- Bicycle rentals nearby
- Golf lessons available nearby
- Golfing nearby
- Scooter/moped rentals nearby
- 24-hour business center
- Computer station
- 24-hour front desk
- Tours/ticket assistance
- Dry cleaning/laundry service
- Free newspapers in lobby
- Luggage storage
- Porter/bellhop
- Number of buildings/towers - 1
- Year Built 2010
- Elevator/lift
- Rooftop terrace
In the room
- Air conditioning
- Minibar
- Coffee/tea maker
- Slippers
- Iron/ironing board (on request)
- Turndown service
- Tempur-Pedic mattress
- Separate sitting area
- Private bathroom
- Shower/tub combination
- Designer toiletries
- Hair dryer
- Cable TV channels
- Desk
- Free WiFi
- Phone
- Free bottled water
- Daily housekeeping
- In-room safe
- Access via exterior corridors
Special features
DiningLa Docel Vita - This restaurant specializes in Asian cuisine and serves breakfast, lunch, dinner, and light fare. Guests can enjoy drinks at the bar. Reservations are required.
Quoc Hoa Hotel - Hanoi's small print
Also known as
- Hoa Hotel
- Hoa Quoc
- Hotel Quoc Hoa
- Quoc Hoa
- Quoc Hoa Hanoi
- Quoc Hoa Hotel
- Quoc Hoa Hotel Hanoi
- Hanoi Quoc Hoa Hotel
Guests booked in a Vietnam Resident Only rate plan must present valid ID with proof of Vietnamese residency at check-in. Guests without valid ID will be charged an additional fee.
Only registered guests are allowed in the guestrooms.
For transfers, guests must contact the property before arrival at the number on the booking confirmation.
Optional extras
Airport shuttle service is offered for an extra charge of USD 645000 per vehicle (one way)
Train station pick-up service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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If your property is under a mandatory or advisory evacuation order, and you need to have your horses evacuated call Santa Cruz County Animal Services: 454-7303 #1. If they are not available call 911 to activate our unit.
Fact Sheet
October 2015
During the Summit, Martin and Trabing fires in 2008, our Equine Evacuation
Unit evacuated over 500 horses and many other animals and livestock.
Only about 20 horses had to be evacuated by our organization during the
Lockheed fire in 2009, because our community was much better prepared
and had made plans for their animals in case of a disaster.
180—Registered OES Trained Disaster Workers with horse trailers and trucks available for emergency use when activated by the County Office of Emergency Services
35— Amateur Radio Evac Members (Hams)
9—Trailer Teams
All Disaster Workers have received Office of Emergency Services Training regarding SEMS-Standardized Emergency Management System and ICS-Incident Command System. Evac members have attended workshops on loading unwilling horses, trailer safety and maintenance and had opportunity to have a free trailer inspection by a local trailer repair expert. Additional trainings have been provided in the past that covered emergency first aid for horses and tips on what to do if the vet can't get there.
Trailer Team Leaders meet periodically to plan strategies. They keep in regular touch with their team members.
We have been activated for two flooding situations and four fires. During our largest single activation we successfully evacuated over 240 horses in approx. 8 hours during the Summit Fire in May 2008.
The Emergency Services Manager, Rosemary Anderson (454-2715), will authorize call outs for any size emergency in which we are required. If you can not reach her call 911. Clearance must be made through her office. Trailer team members can chose NOT to be involved with every emergency.
Please click here for more information as to: WHO WE ARE AND HOW WE OPERATE
Web Site sponsored by Cruzio Internet


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Subsidiary Medal Pick Up
All subsidiary medals (2nd place, 3rd place, etc., depending on the event size) will be available for pick up at the Attager Row tent from Noon to 5PM on Saturday, October 22 and 10AM to 6PM on Sunday, October 23. For crews, one representative may come pick up medals. For youth and collegiate programs, a coach must retrieve the medals. Please note subsidiary medals will not be awarded at the Award Ceremonies.
The number of subsidiary medals depends on the number of entries in the event:
1-9 Entries: up to 1st place awarded
10-19 Entries: up to 2nd place awarded
20-29 Entries: up to 3rd place awarded
30-39 Entries: up to 4th place awarded
40+ Entries: up to 5th place awarded
First Place Award Ceremonies
First place medals and special medals are distributed at the Head Of The Charles Awards Ceremonies at the Attager Row Tent.
Saturday, October 22
3:30 PM Ceremony
Sunday, October 23
3:30 PM Ceremony
5:30 PM Ceremony
The Massachusetts Department of Conservation (DCR) Trophy
The MacMahon Cup Regatta Points Trophy
Medals and Trophies
Read about the storied medals and trophies of the Head Of The Charles Regatta HERE.


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Situated at the south western entrance to the Solway Firth, Whitehaven Marina is the maritime gateway to the Lake District.
The town with all its facilities is within easy walking distance of the harbour making Whitehaven Marina an ideal place to berth if you fancy a few nights in the Lake District.
The harbour also provides an ideally located departure point for Isle of Man, Ireland, Scotland, Clyde and Hebridean cruising.
Marina access and berthing
Whether a resident or visitor you will find all the facilities you need here delivered by our friendly and experienced team of staff.
Whitehaven Marina lock gate
The tidally controlled marina offers near-24-hour access to the 225 berths spread over two basins. The marina berths have access to power and water, with a diesel fuel berth, toilets and showers and car parking all within easy reach.
The marina and/or lock gate staff are on hand 24 hours a day and the marina is closely monitored by 24 hour CCTV.
The marina can lift and relaunch vessels up to 5m in width and 45 tonnes in weight, with hard standing also available for those who need it.
We look forward to seeing you soon. Contact us to arrange a stay with us.
Number of berths: 280
Please call this Marina for berthing rates.
This Marina does not currently have an active Facebook or Twitter account.
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text:
We are using BumGenius for the most part. I stripped them about a month ago after my mom, who watches LO once a week, said that the smell was stronger than normal. It's gotten worse now, I'm wondering if they need to be stripped again, or sunned (it takes a lot to get me outside this time of year)? Vinegar rinse? Maybe the inserts just need some extra rinsing?
Any advice?


text:
Sunday, April 6, 2014
EcoHealth Wellness Center and Detox Spa, the Lowcountry's new premier holistic wellness center, is now open at 1051 Johnnie Dodds Blvd., Suite B, in Mount Pleasant just in time for April's 37th Annual Cooper River Bridge Run. To soothe the post-race injuries for runners and walkers of this wildly popular event, EcoHealth Wellness Center and Detox Spa is hosting a "Recovery Week" April 7-12. During Recovery Week, runners and walkers can take advantage of: one complimentary Migun relaxation massage and one Infrared Sauna Session and unlimited Kangen water. They can also enjoy discounted spa services, consultations on nutrition and detox/body cleanse programs and more. This is a limited offer for Cooper River Bridge walkers/runners only. Bring your number to redeem this free package. The offer expires April 30.
To schedule your Recovery Week appointment or find out the benefits of the sessions, call 843-884-4466.
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text:
Rent Keys to Success in College, Career and Life 4th edition today, or search our site for other textbooks by Carol Carter. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Prentice Hall.
Need help ASAP? We have you covered with 24/7 instant online tutoring. Connect with one of our tutors now.


text:
Snowboarding Forum - Snowboard Enthusiast Forums (http://www.snowboardingforum.com/forum.php)
- Welcome New Riders And New Members (http://www.snowboardingforum.com/welcome-new-riders-new-members/)
- - Another Australian??? (http://www.snowboardingforum.com/welcome-new-riders-new-members/49537-another-australian.html)
Another Australian???
Hi all,
Have been lurking for a while now, never posted...
I live in Sydney and am addicted to snow. My mates and I trek to the Australian alps whenever we can for a fix but it just dosnt compare with overseas!
Anyway, with our season pretty much done, I'm now playing the waiting game to get back up to the Rockies in winter for six weeks. Only 4 months, 21 days,22 hours, and 46 minutes...
Also am in the market for a neversummer cobra 158, just not sure if I should grab one now from the states and pay to get it shipped over (costs over $100) or take my chances and hope that i can find one when i get there?
Hey man. I'm new here too. how is the boarding in Oz? I'm going there next year to travel and i was thinking of going boarding for a few months while I'm out. would it be worth it?
New Zealand may be a better bet, but they had worse snow that us this season.
New Zealand got off to a slow start but improved massively last week of August and early September. Ended up getting a metre and a half in one week and a base of 2.5 metres. Well Treble Cone did anyway. Unluckily for me I was there the week before the dump. Damn it.
If you do consider getting on the snow down here in the southern hemisphere during your travels I agree NZ is the best bet and late August to early September is usually pretty reliable.
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Gene-specific promoter methylation of several genes occurs in aging normal tissues and may predispose to tumorigenesis. In the present study, we investigate the association among blood folate levels, and dietary and lifestyle factors with CpG island methylation in normal colorectal mucosa.
Subjects were enrolled in a multi-center chemoprevention trial of aspirin or folic acid for the prevention of large bowel adenomas. We collected 1000 biopsies from 389 patients, 501 samples from the right colon and 499 from the rectum at the follow-up colonoscopy. We measured DNA methylation of estrogen receptor alpha (ERα) and secreted frizzled related protein-1 (SFRP1) using bisulfite pyrosequencing. We used Generalized Estimating Equations regression analysis to examine the association between methylation and selected variables.
For both ERα and SFRP1, percent methylation was significantly higher in the rectum compared to the right colon (p = 0.001). For each 10 years of age, we observed a 1.7 % increase in methylation level for ERα and a 2.9 % increase for SFRP1 (P < 0.0001). African Americans had a significantly lower level of ERα and SFRP1 methylation compared to Caucasians and Hispanics. Higher RBC folate levels were associated with higher levels of both ERα (p=0.03) and SFRP1 methylation (p=0.01).
Our results suggest that CpG island methylation in normal colorectal mucosa is related to advancing age, race, rectal location, and RBC folate levels. These data have important implications regarding the safety of supplementary folate administration in healthy adults given the hypothesis that methylation in normal mucosa may predispose to colorectal neoplasia.
DNA methylation is increasingly recognized as an alternative mechanism to mutation in the silencing of gatekeeper genes during colorectal carcinogenesis (1). Hypermethylation in CpG islands (CGI) --cytosine-guanine dinucleotide clusters located within the promoter region of many genes-- is commonly observed in colorectal tumors, yet these sites are largely unmethylated in normal tissues (1, 2). During the course of normal aging, however, low level methylation of CGIs in several regulatory or mismatch repair genes has been observed in the normal colorectal mucosa (3–6). The age-related increases in both CGI methylation and risk of colorectal neoplasia has led some to propose methylation as a predisposing phenomenon for colorectal neoplasia (7, 8).
Increased DNA methylation is believed to lead to the silencing of the expression of regulatory or mismatch repair genes which in turn may provide a growth advantage to the affected cells (7, 8). Although the etiology of these age-related epigenetic changes is not well understood, a correlation between methylation levels and personal characteristics of an individual (e.g. diet, lifestyle factors) may provide a biologic link between established risk and protective factors for colorectal neoplasia and risk of disease. The ERα and SFRP1 genes are both expressed in normal colorectal tissue, exhibit intense CpG island (CGI) methylation in colon cancer and are believed to regulate growth and differentiation, two factors associated with tumorigenesis (3–6). ERα was selected because of strong prior data connecting it with aging (a significant risk factor of colorectal neoplasia) and SFRP1 (a known antagonist of the Wnt signaling pathway (9)) was studied because of suggestions that it is a gate-keeper gene in the earliest phases of colorectal carcinogenesis (4). Frequent CGI methylation of the ERα and SFRP1 genes has been observed in several different types of tumors, including breast, prostate, lung, and most colorectal adenocarcinomas (4, 10–13). Methylation of these genes has also been frequently observed in the mucosa adjacent to carcinomas (4, 5, 11) and in normal mucosa in patients with and without colorectal neoplasia (14–18).
In the present study, we examined the association among demographic, lifestyle, dietary, and genetic factors and the degree of gene-specific DNA methylation (ERα, SFRP1) in normal colorectal mucosa among subjects enrolled in a multi-center chemoprevention trial testing the efficacy of aspirin and folate on the risk of large bowel adenomas. Specifically, we examine the association between these factors and CGI methylation in the ERα and SFRP1 genes in both the right colon and rectum.
Our data were collected as part of a randomized, double blind, placebo-controlled trial testing the efficacy of aspirin, folic acid, or both in the prevention of colorectal adenomas (19, 20). Written informed consent was obtained from each participant, and the Institutional Review Board of each participating institution approved the studies.
Study participants were recruited between July 1994 and March 1998 at nine clinical centers in North America. Each participant had a history of at least one colorectal adenoma excised before study entry and had no remaining polyps in the entire large bowel after complete colonoscopic examination. The study had a three-by-two factorial design, comparing 81 mg and 325 mg of aspirin per day with placebo and comparing 1 mg of folic acid per day with placebo. The trial was initially designed to investigate only aspirin, but soon after recruitment began, the study was extended to examine folic acid also. One hundred patients who were randomly assigned to receive aspirin or placebo could not be included in the factorial design for folic acid, but they are in the analyses of aspirin.
Follow-up colonoscopy was performed approximately 3 years after the qualifying examination. Polyps were classified as neoplastic (adenomatous) or non-neoplastic by the central study pathologist, who also assessed the degree of dysplasia and the extent of villous component in each adenoma. We defined advanced lesions as invasive carcinoma or adenomas with at least 25% villous component, high grade dysplasia, or an estimated size of 1 centimeter or greater. In addition to collection of polyps during the year 3 colonoscopy, 84.6% of subjects (914) were approached for permission to obtain normal mucosal biopsies; 781 (85.4%) consented. Of the 167 individuals who were not approached, 92 (55%) were from one center that could not participate in the biopsy study, and the remaining individuals had been randomized only to aspirin.
At enrollment, participants completed a questionnaire addressing basic demographic characteristics, lifestyle factors, medical history, and usual diet (assessed using a validated food frequency questionnaire) (21). We analyzed several demographic and lifestyle factors, including: age (quartiles), sex, race (Caucasian, African American, Hispanic, other), smoking status (categorized as "never", "former" and "current" users), alcohol use (none, ≤ 1 drink per day, >1 drinks per day) and body mass index (BMI) which was divided into three categories using the standard established by the World Health Organization: normal (< 25 kg/m2), overweight (25 to 29.9 kg/m2), and obese (BMI ≥ 30 kg/m2).
At baseline we also assessed several dietary measures using a validated semi-quantitative food frequency questionnaire (21): daily intakes of folate, protein, carbohydrates, fiber, and fat. The estimated intakes of these nutrients were adjusted for caloric intake using residuals computed from the linear regression of the log of the nutrient intake on the log of caloric intake. During the course of the trial, we also asked subjects twice a year about their use of nutritional supplements, including a multivitamin provided to subjects on request that did not contain folic acid. We coded multivitamin use as positive if subject reported usage on one or more of the semiannual questionnaires.
Blood specimen collection and analysis and genotyping assays were previously described (22). Briefly, nonfasting blood samples were obtained from subjects at baseline and at the follow-up approximately three years after study entry using 7-mL EDTA Vacutainer brand tubes. After collection, specimens were immediately put on ice and then centrifuged at 1100 g for 10 minutes. Whole blood, plasma and buffy coat fractions were stored at −20°C for 6 to 12 months, and then transferred to Dartmouth Medical School where they were stored at −80°C until analysis. Plasma levels of folate were determined by a microbiological assay using a colistin sulfate–resistant strain of Lactobacillus leichmannii (23). EDTA samples with low (<2 nmol/L) or no folate, attributable to inhibition of bacterial growth by antibiotics, were reanalyzed with a method based on measurement of folate as p-aminobenzoylglutamate equivalents (24). Circulating levels of plasma B2, B6, B12, and homocysteine were also measured, as were genotypes for key enzymes in the one-carbon metabolism pathway related to DNA synthesis and methylation: CBS-1080 C>T, CBS-699 C>T, MTHFR-677 C>T and1298 C>T, MTR-2756 A>G, D919G and MTRR-66 A>G, as described previously (25, 26). RBC folate was determined by the ACS:180 folate assay, a competitive immunoassay using direct chemiluminescent technology (Bayer Corporation). The year three RBC concentrations were calculated using baseline hematocrit values since these were not obtained at the year three blood draw. Biochemical analyses were conducted blinded to methylation features, randomized treatment assignment, and other subject characteristics.
At the beginning of the year-3 follow-up colonoscopy, two biopsies were taken of normal-appearing mucosa in the rectum (10 cm above the anus). After the endoscope was advanced to the cecum, two biopsies were obtained from the mid-ascending colon (5 cm above the ileo-cecal valve). Immediately after each biopsy was taken, the specimens were removed from the forceps, placed into freezer tubes, and immersed in liquid nitrogen or dry ice/ethanol slurry where they remained until stored in a −70°C freezer at the central facility of the clinical center before shipment on dry ice for analysis.
We obtained the biopsies (as described above) of normal mucosa from 768 (98.3%) of the 781 individuals who were originally consented. Of the 13 individuals who consented but did not provide biopsies, the reasons were: schedule conflicts (n=9), no IRB approval at hospital (n=3), unknown (n=1). Of the 768 participating subjects, we collected a total of 3,072 biopsy samples. Our analysis includes a convenience sample of 1000 (499 from the rectum and 501 from the right colon) taken from 388 individuals. Of these, one subject had only one biopsy from the rectum, 274 subjects had two biopsies (273 from both sides of the colon and one from the right colon only), one subject had three biopsies (one from the right colon and two from the rectum) and 112 subjects had four biopsies (111 had two biopsies from each side of the colorectum and 1 subject had three from the right colon and one from the rectum).
DNA extraction followed standard protocols in the laboratory. Briefly, the biopsy specimen was minced using a razor blade and transferred to a tube containing lysis buffer (1% SDS, 1 mg/ml Proteinase K, LTE pH 8.0). The solution was incubated at 50°C for 1 hour, followed by phenol/chloroform extraction and ethanol precipitation. The quantity and quality of DNA was then determined by running a small aliquot on a 1% agarose gel and comparing it to a set of DNA standards.
Quantitative bisulfite-pyrosequencing method was used for ERα and SFRP1 genes (27). Briefly, 2 μg of genomic DNA was denatured with 2 M NaOH for 10 min, followed by incubation with 3 M sodium bisulfite (pH 5.0) for 16 h at 50°C. After treatment, DNA was purified by using a Wizard Miniprep Column (Promega, Madison, WI), precipitated with ethanol, and resuspended in 30 μl of distilled water. 2 μl of the aliquot were used as template for PCR. For ERα, the primers: TGTGTTTTTTTTTTAGGTGG (sense) and 5′-Biotin AACCATCCCAAATACTTTAATA (antisense) were used to amplify a 125bp fragment of the promoter CpG island. For SFRP1, the primers: TGTTTTTTAAGGGGTGTTGA (sense) and 5′-Biotin CTCCRAAAACTACAAAACTAAAAT (antisense) were used to amplify a 218bp fragment of the promoter CpG island. PCR cycling condition for ERα was denaturation at 95°C for 5 min, followed by 50 cycles at 95°C for 30 s, 56°C for 1 min, 72°C for 45 s, and a final extension at 72°C for 7 min. For SFRP1, touchdown PCR was performed at 61°C for 5 cycles, 59°C for 5 cycles, 57°C for 5 cycles, and 55°C for 35 cycles. For pyrosequencing, the sequencing primers were GGATAAGGTTTGTATTTTG for ERα, and GTTTGGTTTTAGTAAAT for SFRP1. The methylation level was averaged over the following CpG sites (relative to transcription start site): ERα 218, 220, 226bp; SFRP1 -140, -134, -130, -128, -119bp. For each assay, set-up includes positive controls (samples after SssI treatment) and negative controls (samples after whole genomic amplification), mixing experiments to rule out bias, and repeat experiments to assess reproducibility. Optimizing annealing temperature of PCR was used to overcome PCR bias as reported (28).
To assess the reproducibility of measurements in duplicate biopsies, we computed intra-class correlation coefficients, and to assess the reliability of the assays we calculated the Coefficient of Variation (CV) using replicate measures from the same biopsy on separate PCR gels. We had 500 replicate measures for ERα and 1000 for SFRP1. Agreement between measures on biopsies on the right colon and rectum was examined by Spearman's rank correlation coefficient.
We used Generalized Estimating Equations (GEE) regression analysis to assess the association between ERα and SFRP1 gene methylation levels and selected variables. We also analyzed the average of ERα and SFRP1 methylation levels and selected variables using standardized Z scores (29) as described previously (30). Briefly, for each gene we calculated the Z score as (X − m)/s, where X represents the methylation data of each gene in each sample; m represents the mean of methylation of each gene among all samples; and s stands for standard deviation. We then determined the average methylation score by summing the z-scores for ERα and SFRP1 and dividing by two. We used GEE modeling since most individuals had more than one sample, in order to account for the within-subject correlation of measurements from the same site; it is a minor component compared to the demographic differences. For each analysis we produced means and standard errors (se) while adjusting for age as continuous variable, sex, folate treatment assignment, smoking status (never, former and current smoker), and daily alcohol intake (none, 1 or less/day, 2 or more drinks/day) during the 3-year randomized period. Means for dietary intakes of nutrients were also adjusted for log-transformed daily calories. To measure the association between methylation and adenoma risk, we estimated risk ratios (and 95% confidence intervals) for one or more adenomas after randomization, calculated with generalized linear regression analyses using a logarithmic link and a Poisson distribution. We obtained the relative risks and P for trend using orthogonal linear contrasts. We used Wald tests to assess statistical interactions. All effect estimates were adjusted for adjusted for age, sex, folic acid and aspirin treatment assignment, smoking status, daily alcohol intake and time since randomization. All tests of statistical significance were two-sided.
We used analysis of variance methodology to determine the proportion of variance in RBC folate levels explained by folate treatment and other covariates including age, sex, smoking, alcoholic drinks per day, dietary folate and log of calories. We cannot obtain an R-squared using the GEE methodology, because no R-squared extension has been developed that incorporates the correlations estimated in a GEE model. We also computed a coefficient of partial determination to assess the unique contribution of folate treatment to the proportion of variation in RBC folate levels in the multivariate context.
The mean age of the study participants was 57.8 years (SD ± 9.1) and 63.4% were men. The participants in this methylation study were broadly similar to those in the parent study (Table 1). Mean baseline dietary folate intake, baseline plasma folate, and year three RBC folate levels were significantly lower (p < 0.05) in the subjects included in the methylation analysis than in the entire parent population.
We first examined the reliability and reproducibility of the measurements. The CV of the ERα assay was 8.6% and for SFRP1 was 13.6%. For ERα methylation, the intraclass correlation coefficient between duplicate biopsies taken in the rectum was rho= 0.66 (p <0.0001) and rho = 0.63 (p < 0.0001) for the right colon. For SRFP1, the intraclass coefficient between biopsies in the rectum was rho= 0.45 (p < 0.0001) and in the right colon, rho= 0.52 (p < 0.0001). Next, we assessed the patterns of methylation in the right colon and rectum. Overall, for ERα, the correlation between biopsies in the right colon and rectum was r=0.42, (p < 0.0001); for SFRP1 the correlation was r=0.37, (p<0.0001). For ERα, mean percent methylation was 12.1% in the rectum and 9.6% in right colon (p = 0.001). A similar pattern of lower values in the right colon was observed for SFRP1: 23.3% methylation in the rectum and 20.8% in the right colon (p = 0.001).
Increasing age was significantly associated with higher mean methylation levels for both ERα and SFRP1 (Tables 2, ,3,3, ,4).4). The percent increase in methylation for age increments of 10 years was 1.7% for ERα (p<0.001) and 2.9% for SFRP1 (p < 0.001). In general, methylation levels were similar for men and women for both ERα and SFRP1. However, methylation levels among Caucasians, African Americans, and Hispanics exhibited marked differences for both ERα and SFRP1 genes (Tables 2, ,3,3, ,4).4). ERα methylation levels were higher among Caucasians and lower among African Americans and Hispanics (p for heterogeneity = 0.008). We observed a different pattern for SFRP1, with lower mean levels among Caucasians and African Americans than among Hispanics (p for heterogeneity =0.0005). For both genes we also observed significant interactions between race and side of colorectum (p for interaction for ERα = 0.05 and for SFRP1 = 0.009; results are summarized in tables 2, ,3,3, ,44).
We observed no significant associations between BMI level (data not shown), smoking status, or amount of alcohol consumed and percent methylation for either ERα or SFRP1 (Table 2, ,3,3, ,4).4). However, for ERα there was a suggestion that increasing alcohol intake was associated with lower percent methylation (p for trend = 0.07). No pattern was observed for SFRP1.
Neither aspirin nor folic acid treatment was significantly associated with ERα or SFRP1 percent methylation (Tables 2, ,3,3, ,4).4). However, subjects assigned to aspirin treatment exhibited slightly lower ERα methylation in the right colon compared to placebo (p for trend = 0.10). We observed no association between ERα methylation and any dietary variable, including intakes of total fat, carbohydrate, total dietary fiber (data not shown), protein intake, or dietary folate (Table 2, ,4).4). Use of study multivitamins (which did not contain folic acid) during the trial was associated with a lower percent methylation for the ERα genes (Table 2) and for the combined ER-SFRP z-score measure (Table 4). We also observed a significant interaction between multivitamin use and age for ERα (p < 0.01) and a borderline interaction for SFRP1 (p <0.06). Subjects above the median age (> 58 years) who reported taking a multivitamin had lower mean methylation levels (11.4%) compared to those not taking a multivitamin (12.8%). For subjects below the median age who reported multivitamin use, mean methylation levels were higher (9.8%) compared to those who did not (9.5%). A similar pattern was observed for SFRP1: older/multivitamin use (23.5%), older/none (25.3%), younger/multivitamin use (20.0%), younger/none (19.6%).
For SFRP1 we observed a strong inverse association between higher levels of protein intake and lower methylation (Tables 3, ,4).4). Among those in the highest quartile of dietary protein intake, the average percent methylation was 20.9% versus 22.7% for the lowest quartile (p for trend = 0.006). The association was observed in both the right colon and rectum. None of the other dietary variables exhibited an association with percent SFRP1 methylation (data not shown).
There was no significant association between baseline plasma levels of B2, B6, B12 or homocysteine and percent methylation of the ERα or SFRP1 genes (data not shown). We observed no significant association between MTHFR polymorphisms C677T or A1298C and percent CGI methylation for either ERα or SFRP1 (data not shown).
Year three RBC folate levels were associated with higher levels of methylation in ERα, SFRP1 and the combined ERα-SFRP1 measurements (Table 5 and Figure 1). We did not observe any statistically significant interactions between folic acid treatment and RBC folate levels on ERα methylation (p for interaction = 0.54), SFRP1 methylation (p for interaction = 0.15), or combined ERα-SFRP1 methylation (p for interaction = 0.23). There were no significant associations between year three plasma folate levels and SFRP1 or ERα methylation (Table 5) nor were there associations for baseline dietary folate levels.
Folic acid treatment was significantly associated with RBC folate levels. The means (± SE) in the folic acid and placebo groups were 931 (± SE) ng/ml and 682 ng/ml (± SE) respectively (p < 0.0001). Age, and current smoking status were significantly related to RBC folate but not sex, number of alcoholic drinks per day, dietary folate, or log of calories. All of the above variables (including folic acid treatment) explained 19% of the variance in RBC folate levels. The coefficient of partial determination for folic acid treatment explained 13% of the variation in RBC folate levels.
We observed no significant association between ERα or SFRP1 percent methylation level and risk of adenoma or hyperplastic polyps (Table 6). For ERα, those in the highest compared to the lowest tertile of methylation had a RR for any adenoma of 1.00 (0.83–1.21), and for any hyperplastic polyp, 1.33 (0.94–1.84). For SFRP1 in these same tertile comparisons, the RR for any adenoma was 0.93 (0.76–1.13) and for any hyperplastic polyp, 0.98 (0.69–1.38). For both ERα and SFRP1, there were non-significant trends for associations between higher levels of methylation and hyperplasic polyp occurrence in the right colon, but the number of hyperplasic polyps in this study was small.
In this large multi-center clinical polyp prevention study, we found that methylation levels of the ERα and SFRP1 CGIs in the normal colorectal mucosa differed by large bowel region, age, race, and RBC folate levels. Methylation levels were significantly higher in the rectum compared to the right colon, and increasing age was strongly associated with higher levels of methylation in both the right colon and rectum. For both ERα and SFRP1, we observed that Caucasians had higher levels of methylation than African Americans, while Hispanics had relatively low levels of ERα and relatively high levels of SFRP1. We found no significant relationship of the level of methylation for either CGI site with aspirin or folic acid treatment, dietary folate or any 1-carbon folate metabolism polymorphism. However, we did observe a relationship between higher levels of year three RBC folate and increasing levels of ERα and SFRP1 methylation.
Our findings of an age-related increase in CGI methylation in the normal mucosa parallel those of several other investigations (3–6). Our study is one of two to document age-related increases in SFRP1 methylation within the normal mucosa (14). Another investigation (31) reported no evidence of SFRP1 methylation in the normal mucosa in a younger study population (ages 20–54). Other studies have reported low-level SFRP1 methylation in normal tissue adjacent to tumors but no effort was made to examine an association with age (11). For ERα, the evidence of an age-related increase in methylation in the normal colorectal tissue has been documented in most other investigations (4–6) yet not all (14). While the differences detected are small in some instances (2–4% methylation), they can be significant if they represent differences in the numbers of colorectal crypts with dense methylation. This has previously been shown to be the case (32).
Investigators have become increasingly aware that there are clear physiological, morphological, and biochemical differences between the right and left colorectum (33, 34) and these differences may shed light on why we observed differences in methylation between the right colon and rectum (33, 34). Our results parallel an earlier study which also showed higher ERα methylation levels in the left colorectum compared to the right (4), although in that study the samples were selected from a mix of patients with colorectal cancer, adenomas, other disease, and sigmoidoscopy only 'normal controls,' which represents a subject population that may limit comparability with ours. Of the two other investigations (6, 35) which examined ERα methylation in normal colorectal mucosa, one (35) reported no difference by anatomical location, and in the other biopsies were selected from the rectum only (6). In the first study to show no difference by region of the large bowel (35), no description is provided about the number of right versus left biopsies.
Why methylation patterns may differ by large bowel region is not well understood. Theoretically, the differences in CGI methylation between the right and left colorectum may be driven by physiologic/biologic differences in the anatomic regions. For example, there are many known differences in the biology of the right and left colorectum such as different embryologic origin, crypt length and apoptotic index (33, 34). Alternatively, the higher methylation levels that we observed in the rectum may be specific to the ERα and SFRP1 genes, and other CGIs might show a different pattern.
In our study population, African Americans had lower levels of methylation compared to Caucasians and Hispanics. We believe that our study is the first to consider CGI methylation levels in normal colorectal mucosa of different racial groups. One other study reported no significant difference in ERα methylation levels in colorectal tumor tissue when comparing Caucasian and non-Caucasian persons, yet the average ERα CGI methylation level was higher in Caucasians (36). There are several possible explanations for our findings, including lifestyle factors, genetic protection or predisposition to methylation and polymorphisms in the genes studied themselves. Still, the number of African Americans studied is small, and our findings could also be a result of chance.
Very few of the lifestyle or dietary variables we examined were related to CGI methylation levels. Previous research has suggested a relationship between dietary folate and genomic methylation in normal mucosa (37, 38), but our study is the first to examine the association between folic acid supplementation and CGI methylation in normal tissue. In findings consistent with ours, another study reported no association between serum folate levels and ERα methylation in normal mucosa (6). However, we did observe that RBC folate levels were positively associated with ERα and SFRP1 methylation levels. It is interesting and biologically relevant that RBC folate levels showed a stronger association than plasma folate. The former more closely reflect long term intake, and also reflect intracellular folate directly. In light of these data, it might seem surprising that randomization to the folate supplementation arm was not associated with a difference in DNA methylation. This is likely due in part to the fact that the difference in RBC folate between the placebo and folate treatment arms (249 ng/ml) would correspond to less than a 0.5% difference in ERα and SFRP1 methylation, something that would be difficult to detect with this technology and sample size. These data have important implications regarding the safety of supplementary folate administration in healthy adults, given the hypothesis that methylation in normal mucosa may be a predisposing phenomenon for colorectal neoplasia (discussed below).
All patients had detectable levels of ERα and SFRP1 methylation and no significant differences were observed among patients with and without recurrence of colorectal adenomas. This implies that ERα and SFRP1 methylation are not rate-limiting in the development of adenomas in this population, and is consistent with the idea that a mutation in APC (39) is a critical first step in this regard. However, there may be other age-related methylation genes such as MYOD1, DKK1, HPP1 (14, 16–18) that could be associated with adenoma occurrence. It has also been proposed that mutations of these genes may be more likely to occur in a "predisposed" mucosa, and that aberrant DNA methylation is one of the factors that results in this predisposition (40).
To test whether DNA methylation does in fact lead to this predisposition, one would need to study a mixed population with patients at high and low risk of adenoma formation, something that was not done here, given that all patients had adenomas at study entry. Comparing results across studies is difficult for many reasons, including differences in: (1) the genes examined (2) the control for confounding variables such as age and sex or (3) the colorectal location(s) selected for mucosal sampling (18). Despite these challenges, several studies have examined CGI methylation levels in the normal mucosa of persons with and without neoplastic lesions (14–18, 41, 42). Of these, five have specifically examined ERα and SFRP1 (14–18). Four of these studies have reported lower ERα methylation (14, 16–18) among those with advanced neoplasia compared to adenomas or disease-free controls, while one reported higher ERα levels in adenoma patients (15). SFRP1 was associated with lower levels of methylation in mucosa of patients with neoplasia compared to those without in one study (18), and was unrelated to pathology in another (14).
Although not statistically significant, we observed that a higher level of ERα methylation was associated with an increased risk of hyperplastic polyps, especially right-sided hyperplastic polyps. Interestingly, two other investigations (6, 18) also observed increased levels of ERα CGI methylation in the normal mucosa in persons with hyperplastic polyps or proximal serrated polyps compared to controls. Historically, hyperplastic polyps have been considered indolent, non-neoplastic lesions (43, 44). However, currently it is understood that a subset of "hyperplastic" polyps are in fact sessile serrated adenomas, the precursor lesion to cancers evolving along the serrated adenoma pathway (45, 46). The lesions of the serrated pathway have been closely associated with the CpG island methylator phenotype (CIMP) which involves the methylation of multiple cancer-specific CGIs (1, 47–49). Future studies will be needed to determine if CGI methylation in the normal mucosa predisposes toward to serrated lesions, since these lesions appear to have a somewhat distinct epidemiologic profile (50).
There are several strengths to our study. First, we examined methylation levels in a well characterized population, with a systematic protocol, using a quantitative technique capable of detecting low-level methylation. ERα was selected because of strong prior data connecting its methylation state with aging, and SFRP1 was studied because of suggestions that it is a gatekeeper for neoplasia in the colon. The fact that ERα and SFRP1 methylation was consistently correlated with age (and with each other) confirms the validity of the measurements. Additionally, subjects were part of a large, multi-center polyp prevention study with excellent follow-up and compliance with treatment. Ours is the first study with the magnitude and rigor to examine the effect of folic acid supplementation on methylation levels. Limitations to the study include the entry criteria: all subjects had at least one adenoma, and so may be different from patients with no history of polyps. Thus, it remains to be determined whether mucosal methylation levels are lower in individuals who never develop adenomas. Furthermore, we used a convenience sample of specimens, which may not reflect the entire population of 768 persons with biopsies. There was a relatively low intraclass correlation between biopsies in a given individual. Given the relatively low CV of the assay, the primary reason for the low correlation is likely due to the natural variation of the biopsies. It will be important in future studies to obtain duplicate biopsies from many segments of the colorectum given the known biologic and anatomical differences which occur by region.
Overall, our study results point to differences in methylation levels by age, race, different regions of the large bowel and RBC folate levels. This is one of the first large scale studies to document associations between epigenetic measures and dietary factors in adults.
JPI is an American Cancer Society Clinical Research professor supported by a generous gift from the F. M. Kirby Foundation.
Funding: This work was supported by the National Cancer Institute at the National Institutes of Health (R01-CA105346 and R01-CA89245 to JPI, N01-CO-12400, R01-CA-059005 and U54-CA100971 to JAB).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Hearing aids in Dunnellon, FL
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February 11, 2014
I don't know how jet
Pintacals Park
Looking for friends that actually want to do stuff to pull me out of my empty nest in S Cz county
So far so good, with out this notice I would not have know of this activity . I would have regretted it if I had missed it.
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Eight of the veteran Amarillo Bulls players were setting up for a photo shoot this week with the Robertson Cup.
As the shoot continued, the Robertson Cup was needed to be moved a few feet forward.
Bulls captain Mike Davis piped up and said, "Don't touch it."
Bulls equipment manager Bernie McDonnell grabbed the Robertson Cup and moved it forward as goalies Paul Berrafto and Collin Delia wiggled and waggled making sure the Cup didn't touch their bulky leg pads.
"It's a new year," Davis said. "Nobody touches the Cup."
Davis and the seven other Bulls players in the photograph have had a tight grip on the Roberston Cup, which celebrated the Bulls 2013 North American Hockey League Tier Two Junior Hockey championship.
The Bulls begin defense of that Robertson Cup tonight, which means a chance to grip the Cup again in 2014.
"Defending the crown is very important to us," said Davis, who led the Bulls in scoring with 63 points and ranked third in the NAHL. "I want to win it again, and everybody on this team wants to get a taste of a championship. It's going to be a fun ride for us."
Berrafto has been with the Bulls for three years and has seen one year end without the Cup and one with the Cup.
"All the work you put in, it's terrible to come up short," Berrafto said.
Amarillo opens its Cup quest — it will take 10 playoff wins to win the title — with a best-of-five South Division semifinal series against the Wichita Falls Wildcats at 7 tonight in the Amarillo Civic Center Complex Cal Farley Coliseum.
Amarillo (40-14-6, 86 points) earned home ice advantage by winning the South Division. Wichita Falls finished fourth in the division at 35-21-4 (66 points).
However, Wichita Falls was 3-1 — two of the victories in a shootout — during the regular season games between the two teams played in Cal Farley Coliseum. The Wildcats won two games in a shootout.
Wichita Falls relies heavily on goalie David Zevnik and forward Kyle Bauman. Zevnik has been strong in the nets lately and beat Amarillo 3-2 in a shootout March 22 in Amarillo. Bauman leads Wichita Falls in scoring and the lone 20-plus goal scorer with 21.
Bulls coach Dennis Williams said he respects what Wichita Falls accomplished, but the regular season record in Cal Farley doesn't concern him.
"No, because we have a couple of shootout losses in there," Williams said. "Our own record is one of the tops in the league. No matter who you play is going to be a tough opponent. Obviously, Wichita Falls is a very good hockey team. At this time of the year, it's not who we are playing. But we need to focus on ourselves and concentrate on how we play."
The Bulls are a different team from last year with more skill level on offense but haven't displayed the grind-it-out grit last year's team was known for.
Still, the Bulls won the South Division for the third season in a row, and Amarillo proved clutch by securing that title with a win on the last night of the regular season.
"That South Division title was a big accomplishment for this group," Williams said. "It's not easy as every year gets harder and harder. But you put it in perspective and this is the third one in a row. There was a lot of pressure to win the South. My hat's off to these young men for what they accomplished."
Amarillo's Tyler Gernhofer was the lone player in the NAHL to score at least 30 goals, finishing with 31.
Wichita Falls also will have the challenge of scoring against Amarillo's goalie duo of Berrafato (18-7-3, 2.12) and Delia (22-7-0, 1.60 goals against average).
The pair have traded off all season long, and both have signed to play at the Division I level (Berrafto with Holy Cross, Delia with Merrimack College).
"We believe we have the best two goalies in the league," Williams said. "I wouldn't trade those two for anybody."
Williams said to be a good playoff team in 2014, the Bulls must avoid silly penalties, be the first on pucks all over the ice and play with a toughness.
"Everything changes with playoff hockey," Williams said. "The intensity finds a new gear. But you also you have to enjoy where you are, and that's being one of the playoff teams."
Amarillo was the No. 1 playoff team in the NAHL in 2013 and that's why the Robertson Cup has been parked in Amarillo the past year.
Tonight the Bulls begin the quest to keep the Cup in Amarillo with new finger prints on it.


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- Home
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- Bubble Blast Rescue
Bubble Blast Rescue
>Release date: 18 Jul, 2012
Publisher: Magma Mobile
Genre: Arcade & Action
ESRB/ Pegi:
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Bubble Blast Rescue ANDROID Game
Price: Free
Game size: 14 MB
Bubble Blast Rescue - Short description
Will you save them all ?
Help save the Bubble Blast from horrible enemies who are keeping them hostage on remote islands!
Set in stunning 3D environment, your job will be to throw Bubble Blast at enemies and push them into the surroundings water. Be aware that the enemies are smart and have protected themselves in such a way you could lose Bubble Blast friends if you are not careful enough.
The game will give you the opportunity to play 10 levels so you can have a great feel for what the game offers. For those of you who wish to play a total of 150 amazing levels, you will be given the opportunity to purchase additional levels through in app purchasing.
Bubble Blast Boxes requires skills to achieve a perfect score. The better you get at the game you came, the more stars you will get which will lead you to unlock levels later on in the game.
Come Play Bubble Blast Rescue today. Hours of fun ahead of you!
Source: Wikipedia, Game's homepage
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Lunchtime Beauty Q&A: How Do I Avoid Lipstick Buildup?
Piling up on pigment just makes it look worse.
Piling up on pigment just makes it look worse.
Plus, Marni is looking for an investor, should you be interested.
Plus, Karlie Kloss admits she wasn't always perfect.
Be your own personal galaxy.By Diana Tsui
But it's not oily.By Christina Han
WAR.By Hilary Moss
"Life, I have sacrificed life."By Hilary Moss
He's showing Sunday night, instead of Monday morning.By Hilary Moss
Plus, everyone's up in arms over Natasha Poly's Vogue Russia cover.
Plus, everybody dances.By Hilary Moss
Crisp white suits in Milan.By Charlotte Cowles
Plus, Caroline Trentini and Hilary Rhoda in the Alps for Bally.By Ally Betker
He might leave it to a foundation. He might not.By Hilary Moss
Plus, Victoria Beckham's latest magazine cover, Bar Refaeli's dream husband, and more fashion news.
Plus, Karolina Kurkova covers June's Vogue Mexico.
He shows a "hint of remorse" that he didn't join up with LVMH.By Charlotte Cowles
Plus, Claire Danes covers Harper's Bazaar Russia in Prada.
She wore a Giorgio Armani jumpsuit to a Men in Black 3 premiere yesterday.By Ally Betker
Yes, wear them.By Charlotte Cowles
Now that people can't speculate about Dior anymore.By Charlotte Cowles


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+ Visa service to Laos, Cambodia, Myanmar and China
+ Airport transfer (4, 7, 15, 24, 45 seats)
+ Car, van, bike, sport bicycle hiring
+ Water Puppet show ticket booking


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The result of a review of the taxi industry first ordered in 2011 will come to the Licensing and Standards Committee next week, containing 40 recommendations from city staff.
The recommendations include a new $25 "vomit" fee that can be charged if a passenger "soils" a vehicle and studying the possibility of equipping every vehicle with electronic payment options.
Among the recommendations includes one to allow drivers the option of charging passengers $25 dollars as soon as they get in the vehicle, which like paying before you pump gas, is seen as a way to keep drivers safer and prevent people from skipping payment.City staff believe the changes, many of which that are centred around the way cabs are licensed, will keep fares in line, by cutting out some of the middlemen in the current system.Toronto's taxi rates are some of the highest among comparable North American cities.
No rate increase is being recommended and there is a call for a study on shields that separate a passenger and a driver.If approved the new recommendations would require anyone acquiring a new taxi license to ensure their vehicle was equipped to handle passengers in wheelchairs.
Welcome to TED Radio Hour hosted by Guy Raz, Saturdays at 6pm and Sundays at 7pm


text: VIDEO: Mike Evans Wants to Learn and Lead Sports Talk Florida | May 22, 2014 2:04pm Mike Evans may new to the Buccaneers' squad, but he wants to be a leader. Evans told us that he wants to learn as much as possible. But, his main reason for being here is to be a leader.


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U.S. airstrikes in Iraq are helping to weaken the jihadist army known as Islamic State, or ISIS. This weekend, the U.S. military assisted in a humanitarian operation to free the town of Amirli from a six-week siege. American, British, French and Australian aircraft also dropped food and water to help the thousands of people living in Amirli. But lawmakers say it's time to expand on those airstrikes and confront the Islamic radicals who continue to wreak havoc in Iraq.
Islam: Religion of Peace or War?Arabic scholars bring you a historical and shocking narrative on the tenets of Islam and the life of its founder. Know the truth. Download now.
"We now are facing the largest, most powerful, wealthiest terrorist organization in history, and it is going to require some very strong measures to defeat them," Sen. John McCain, R-Ariz., said.
Democratic Sen. Dianne Feinstein agreed.
"This is a vicious, vicious movement and it has to be confronted," the California lawmaker said. Many believe ISIS is a direct threat to the West. Three days after Great Britain increased its terrorist threat level from "substantial" to "severe," lawmakers in Washington are warning against underestimating the potential threat to the United States. According to U.S. intelligence, more than 100 Americans have joined the ranks of ISIS. The concern is they'll use their passports to get back into the country.
"Al Qaeda didn't need a grievance to attack us on 9/11," said Rep. Peter King, R-N.Y., who sits on the House Homeland Security and Intelligence Committee.
"These groups, they don't need any excuse," he continued. "They will attack us whenever they can. I believe strongly that ISIS does plan on attacking the United States."
UK Sounds ISIS Alarm as US Admits to 'No Strategy'
Enemy Inside: ISIS the 'Greatest Threat since 9/11'
ISIS, Ukraine Spotlight 'Feckless' US Foreign Policy
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Find peace with God, discover more about God or send us your prayer request.
Call The 700 Club Prayer Center at 1 (800) 823-6053, 24 hours a day.
A caring friend will be there to pray with you in your time of need.
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Caitlin Burke serves as a reporter for CBN News. Some of her recent stories have focused on the Millennial generation, technology, the coal industry, the U.S. power grid and the reshoring effort.
Follow Caitlin on Twitter @CaitlinKBurke and "like" her at Facebook.com/Caitlin.Burke.CBN.News
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With the 2016-17 school year underway PG lists top conferences based on the top 100 recruiting classes, which includes the top-ranked North Carolina Tar Heels and their top recruit, Austin Bergner.
Barrett Loseke carried a successful freshman season at Arkansas over to the summer in the Coastal Plain League as we provide detailed scouting reports of the top 20 prospects in the league.
The All-Tournament Team from the 2016 WWBA South Qualifier held in Tomball, Texas, is now available and includes MVP Caden McMullen of the event champion Premier Baseball Futures-Nixon.
See the top incoming freshmen for the 2016-17 college baseball for all 31 Division I conferences, as well as Junior College and Division II, which includes lefthander Nick Lodolo now at TCU.
Kyle Johnston's big arm defines Texas heat as he helped lead the Santa Barbara Foresters to a California Collegiate League championship as we provide scouting reports on the league's top 20 prospects.
The All-Tournament Team from the 2016 WWBA Southeast Qualifier #2 is now available, which includes MVP William Prater of the event champion Nelson Baseball School.
Perfect Game lists the top 400 prospects that have bypassed professional baseball and have decided to go to college, including 2015 PG All-American shortstop and Florida State recruit, Drew Mendoza.
The All-Tournament Team from the 2016 WWBA Northeast Qualifier, held September 16-19 at Morie Park in Vineland, N.J., is now available.
Improved command led to a big summer for hard-throwing, big-bodied UC Irvine lefthander Cameron Bishop as we provide detailed scouting reports on the top 10 prospects from the West Coast League.
Jose Fernandez, who was tragically killed along with two others in a boating accident Sunday, made a very quick ascent and had a significant overall impact at the big league level after an equally dominant amateur career.


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Leftovers that you have planned when you were cooking.
I will just make more lasagna, so we will have some plannedovers for the rest of the week.
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Planned leftovers. You make more than enough for a meal so you know you'll have leftovers.
We had enough plannedovers from Thanksgiving to make pot pies for Christmas dinner.
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Bill posters will be prosecuted
I refer to S. A. Buhari's letter ('Curb law-breakers' South China Morning Post, August 1). Any person who posts bills or posters in public places without permission from the authority commits an offence. Under the law, prosecution can also be taken out against the advertiser and beneficiary of the bills or posters. Upon conviction, an offender is liable to a maximum fine of $10,000.
To tackle the problem of unauthorised posting of bills and posters, the Food and Environmental Hygiene Department has set up dedicated poster-removal teams responsible for patrolling blackspots, taking prosecution actions and removing illegally displayed materials. From January to June this year, we have removed more than 1.1 million unauthorised roadside bills and posters. During the same period, about 250 prosecutions were taken out against bill posters and beneficiaries.
Assistant Director
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The Saints had three chances on their final drive with under three minutes in the game to salt the game away. They chose an off-tackle run, a quick toss out of the shotgun, and a play-action bootleg pass that proved to be their undoing. It also was a good example of well-disciplined football by the Patriot defense.
Following a Brady interception with 2:16 left in the game, the Saints began their possession on their own 29-yard line and the Patriots had only one time out left.
The Patriots brought safety Steve Gregory (#28) up near the line of scrimmage, clearly expecting the Saints to run the ball.
It's important to note quarterback Drew Brees in the upper right corner continued to run after the hand-odd positioning his body in such a way that a defender might think he kept the ball. Make a mental note of his posture as it will become relevant again on third down.
The Saints gain just two yards on the play and the Patriots immediately use their final timeout with 2:05 left on the clock.
The Saints on third down deserve criticism for their play call. After attempting a straightforward run on first down and a quick toss in the shotgun formation on second down, the Saints decide to again try to use deception to fool the Patriot defense on third down.
The problem with this plan was Chandler Jones (#95), who never takes his eyes off Brees and follows him outside the pocket.
That brings up the other odd aspect of this play call; there's only on receiver running a route. Not only that, but it's a relatively low percentage route as it involves Robert Meachem (not the greatest hands) running deep down the middle of the field, away from Brees. There's no Saint on a short crossing route or wheel route, or any kind of checkdown at all. Brees has two bad options; throw the deep ball to a covered Meachem or try and evade Jones in the open field.
Don't overlook the play calling by the Saints and the good example of well-disciplined football by the Patriot defense. Ninkovich was critical in stopping the first two running plays. He stayed with his assignments and did his job. Similarly, on third down, Jones showed excellent discipline by staying with his assignment and not falling for the fake.
Gregory also played a role on all three players as he recognized the fake run on third down and was in the area to help double up Meachem down the field. This may have made Brees hesitate to throw the ball thereby aiding in Jones' tackle.
This was a win for Brady and a win for the Patriots defense.
Michael Reardon is a Fantasy Football writer and Patriots Insider columnist who has followed the New England Patriots for years. An amateur football player himself, Michael uses his knowledge and experience to illustrate the finer points of the game. You can follow him on twitter @mjreardon
[Disclaimer: Images courtesy screen shots of game replay and are copyright of their respective owners including (but not limited to) the NFL, Buffalo Bills and New England Patriots. Images used for illustration purposes only.]


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Dark Reel
Adam Waltz (Edward Furlong) is in a blood drenched horror film produced by Connor Pritchett (Lance Henriksen). Detective Shields (Tony Todd) tries to unravel the mystery of real murders before the ghost of Scarlett May can strike again.
- Length
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- Added Feb 10 2009
- Production Year 2008
- Empire SKU 1453429
- UPC Code 812862010048
- Studio North American Motion Pictures
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Director's Commentary
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Stills Gallery
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£100m Heythrop College put up for sale by Jesuits
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Everybody, it seems, has a story about how cheap cars were in the old days. From gently wrecked Ferraris, now worth millions (or tens of millions) of dollars that sold for the cost of a three-year old Corvette; or winged Mopars that dealers couldn't discount deep enough to sell; or even Model ... Read more
1979 Pontiac Trans Am 10th Anniversary Edition. From the seller's description: I am not going to bore you with Trans Am facts. You already know about these cars. I was able to purchase another toy which means that the Trans Am should go to keep the peace and free up storage space. This 10A/E ... Read more
In 1982, Pontiac debuted an all-new Firebird with a radical aerodynamic shape, the first significant redesign of the model in 13 years. Not content with the car's already slippery shape, in 1984 the automaker introduced an aero kit that lowered the car's coefficient of drag to a claimed 0.299, ... Read more
The 1979 Pontiac Trans Am 10th Anniversary Edition crosses the block. Photos courtesy Barrett-Jackson. In 2011, a 1979 Pontiac Trans Am 10th Anniversary Edition with less than seven miles on the odometer raised eyebrows when it sold at auction for $85,000, or roughly $35,000 over then-published hig ... Read more
With both cars in the garage, there isn't much space to work on the T/A, unless the Buick can be pulled out, which isn't an option when the snow flies. Photos by the author. If you have read my blogs over the last couple of years, you know that I have a few never-ending projects, and th ... Read more
Photos by author. Though I'm partial to muscle cars, I like a lot of different vehicles for more than just their performance potential. Much of what draws me to them are specific visual cues—the way a certain area is styled or particular components or attributes that make me react like Pavl ... Read more
A 1977 Pontiac Trans Am, formerly owned by Burt Reynolds. Photo by Edison Graff, courtesy Julien's Auctions. Released in 1977, the movie Smokey and the Bandit probably did more to sell Pontiac Trans Ams than any advertising campaign in the brand's history. As the second-highest grossing ... Read more
GM press photo. I like animals just as much as the next person. I grew up with cats, dogs and tropical fish in the house most of the time. When I became a teenager, however, I developed allergies, and one was to pet dander. While I haven't been able to own or come in regular contact with furr ... Read more
If a car has flaws, many owners are reluctant to discuss them in fear of lowering the selling price. Worse, unscrupulous sellers may focus on addressing a car's cosmetics, hoping that shiny paint will distract a potential buyer enough to ignore signs that would tell more savvy shoppers to run ... Read more
Though second-generation Firebirds, constructed from 1970 to 1981, have not always been atop the list of must-have muscle cars for GM collectors, that's been changing in recent years as younger enthusiasts begin to seek out cars from their formative years. If you're looking for an F-bod ... Read more


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Cherished, rare times where there is peace and understanding among different people, often while enjoying a good meal.
Riders from all over the world felt the bond of brotherhood at the Tour De France awards banquet; it was a real kingdom moment.
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The Sunday Times bestseller
Winner of 'Best Sewing Book' in the British Sewing Awards 2014
Includes five full-scale printed sewing patterns
Signed by the author!
Love at First Stitch offers a refreshing approach to dressmaking for modern makers. With jargon-busting tutorials and a down-to-earth attitude, the book takes you from the absolute basics of threading your sewing machine through to creating a wardrobe full of gorgeous clothes that you'll be proud to say you made yourself.
"Best sewing book I've ever read. And I've read A LOT!!" - Clare
Since the best way to learn is to get stuck in, Love at First Stitch starts you sewing straight away. Each chapter focuses on a project from one of the adorable garment patterns included with the book. You don't need to plough through a bewildering manual to work out how to make them - new techniques are introduced as and when you need them, so you can build your skills and confidence one project at a time.
The book includes full-scale pattern sheets in 8 sizes ready to use or trace off. The patterns are: Margot pyjama bottoms, Delphine skirt, Megan dress, Mimi blouse, Lilou dress - plus instructions for drafting your own simple patterns for the Brigitte scarf and Clémence skirt. You can see large photos of the patterns here and check out what readers are making on the Pinterest gallery. Variation ideas are offered for each project so you can add your own special touch and make your clothes unique to you.
"Out of all the sewing books I have read over the year or so, yours was the first that actually made me feel I could sew clothes without it being too scary!" - Marcia
Love at First Stitch is also available in Czech, Danish, Dutch, Finnish, German, North American English, Norwegian and Swedish.
Want Tilly to write a personal dedication in the book? Email a message up to 20 words to office [at] tillyandthebuttons.com within 30 minutes of placing your order :)
Published by Quadrille
SIZES (body measurements)
|76cm (30in)
|61cm (24in)
|84cm (33in)
|81cm (32in)
|66cm (26in)
|89cm (35in)
|86.5cm (34in)
|71cm (28in)
|94cm (37in)
|91.5cm (36in)
|76cm (30in)
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|81cm (32in)
|104cm (41in)
|101.5cm (40in)
|86.5cm (34in)
|109cm (43in)
|106.5cm (42in)
|91.5cm (36in)
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|112cm (44in)
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|119.5cm (47in)


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Celebrate Star Wars Reads Day at the Reynolda Manor Branch. DIY lightsabers, Star Wars LEGOS, and more!
Enjoy these films from France and Australia on three Tuesday nights in October.
This month, Zach Leonard of our Carver School Road Branch shares some of his favorite World War II military history titles.
LEGO Club will return at the Reynolda Manor Branch Library on the first Tuesday of the month at 4:00 PM. For girls and boys in grades 1-5. Join us on Sept 6th!
Children's Storytime, Music & Movement, and more will return from Sept - Nov.
The Reynolda Manor Branch Library currently is the largest branch facility in the Forsyth County Library system with 17,000 square feet of floor space. Community use is active, reflected by a high circulation (more than 270,000 checkouts) and over 25,000 registered borrowers. This full-service branch is located in northwestern Winston-Salem and attracts a multigenerational and multicultural customer base.


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Twisted Snake Nipple Stirrup is a very beautiful nipple jewelry piece. It consists of a straight barbell and a stirrup attached to it.
The barbell itself is made of Surgical Steel so it's body-safe and doesn't cause allergies. The stirrup is made of Sterling Silver. It's beautifully designed in the shape of two twisted snakes with clear gems in their eyes.
I bought these for my GF and she loves them. They are very sexy, and the fit was perfect.
(Posted on 10/6/13)


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This item from Kirsten's Corner is now in the Shop Backroom.
More from Kirsten's Corner
Brass Figural Eagle Desk Top Wax Seal Circa 1880
This a a Striking Spread Eagle Brass Desk Top Wax Seal. The eagle stands a top a multi tiered round blank seal it's toes curled. Balanced in between it's wings is a ball with a final top. The seal is heavy as it is solid it also comes apart in three sections that screw together seamlessly. The detail on the eagle is beautiful highlighting individual feathers, it also has a beautiful glowing patina It would make a great addition to any seal collection or to just set upon your desk. Circa 1880.
If you were the pending buyer of this item, go to My Account to view, track and check payment for this item.
Kirsten's Corner
Cindy Kolodziejski, Venice, CA
Finely Curated Eclectic Antiques and Collectibles in a Variety of Mediums
I will be at Mercanteinfiera in Parma Sept 28- Oct 7th on a buying trip!
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Advanced Chart
PRO Research
Elron Electronic Industries: Bargain Price With Outstanding Potential
Sebastian Grimberg
Sebastian Grimberg
Dec. 8, 2013, 5:19 AM
- Covidien (COV) has agreed to acquire Given Imaging (GIVN), an Israeli provider of an ingestible camera for diagnosing stomach problems, for $860M.
- The offer of $30 a share represents a premium of 27% over Given's closing price on Nasdaq on Friday. Shares in Tel Aviv have jumped 21%.
- "We believe GI (gastrointestinal) is one of the most attractive specialty procedure areas," said Covidien's (COV) Bryan Hanson. "Acquiring Given will enable Covidien to significantly expand its presence in a $3B GI market."
- Covidien intends to finance the transaction, which is expected to be completed by March 31, with cash on hand.
- The Irish-based firm forecast that Given will add $40-50M a quarter in incremental revenue. The acquisition is seen as being neutral to operating margin and adjusted EPS in FY 2014, and then as adding to those metrics in 2015 and beyond.
- Given shareholders that control 44% of the company have approved the deal, including Elron Electronic Industries (ELRNF). (PR)


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MOBILE, Alabama – Regulating digital signs on commercial properties will have to wait another two weeks after Mobile City Council members debated how far they should be placed from residences and whether they should be included on two-lane roads.
With unanimous vote, the council opted to wait until its May 28 meeting to vote on the proposed changes that restrict digital on-premise signs to 300 feet from a residentially-zoned area.
"We'll see if we can compromise on a city-wide movement on this," Councilwoman Gina Gregory said. "If not, we'll look at another way to do this."
Two sticking points arose from the council's discussion highlighted by concerns from Councilman Fred Richardson about digital signs advertising a business being allowed only on four-lane thoroughfares that are mostly located in west Mobile.
Richardson, who represents the city's northern neighborhoods, said the proposal is largely unfair to minority businesses that locate along two-lane highways within his district.
"The largest minority business district in the state of Alabama is going to be along the St. Stephens Road corridor from Ann Street to Prichard," Richardson said. "That's Highway 45, and it's a two-lane road. The citizens have nothing to do with it being a two-lane road. We are telling those people, 'no digital signs for you.'
Another concern, raised by Councilwoman Bess Rich, is that the signs – as proposed in the ordinance change – are not located far enough from residential properties.
She proposed that instead of a 300-foot buffer, that signs be placed 500 feet from residential areas. Originally, she was supportive of a 1,000-foot distance.
Rich also said she was concerned about digital signs creating "clutter" and hurting the city's aesthetics at a time when Mobile is attempting to attract suppliers and other businesses connected to the Airbus manufacturing plant project.
"It would be nice to show an aesthetically clean profile," Rich said.
As proposed, the amendment to the sign ordinance regulating on-premise digital signs would prohibit them from locating along commercially-zoned properties that front a street "not less than four" traffic lanes. Also, if signs are located closer than 300 feet from residential properties, they must be completely shielded.
Brightness is also regulated during the day and night hours, advertising off-premise businesses are prohibited and a default design is required in case a sign freezes if it malfunctions.
The ordinance changes do not address off-premise digital billboards, which are prohibited from being located closer than 500 feet from residential property. On-premise digital signs that are already existing in Mobile would be grandfathered into the ordinance, and not subject to the restrictions.
The proposed ordinance change first surfaced as one of about 20 proposed amendments to the city's sign ordinance that was presented to the city's planning commission about one year ago.
The village of Spring Hill then pushed for regulations within their residential neighborhoods.
Linda St. John, president of the village of Spring Hill Inc., said she was supportive of the regulations as a way to preserve neighborhoods.
"We feel the ordinance as written is not only a good ordinance for the village of Spring Hill, but for the city as well," she said. "We are not interested in banning digital signs. People can still have lighted signs, (but) digital signs, we feel, are not appropriate for some of these smaller areas in Mobile."
Richardson said he would support a measure for the village of Spring Hill, but that an ordinance change affecting the whole city based on a neighborhood concept "is not going to work."
"District 1 would be harmed by that," he said. "You can't be arbitrary and capricious. You can't have an (ordinance change) that benefits one side and destroys the other."
He added, "We're not talking billboards here. We are talking signs. You have to treat all of our businesses the same."


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ANN ARBOR, Mich. (AP) - Chris Webber took small gifts and spending money from a former Michigan booster but nothing close to the thousands of dollars alleged by prosecutors, a lawyer for the Sacramento Kings star said.
A federal indictment alleges ex-booster Ed Martin loaned Webber about $280,000 from 1988-93, a period extending from his freshman year in high school through his sophomore season at Michigan.
Martin is accused of loaning more than $600,000 to Webber and three other Wolverines to help conceal illegal gambling profits.
"He (Martin) may have provided some assistance, whether it was a hamburger or something, but I can't even speak to that directly because I have no personal knowledge of it," Fallasha Erwin Erwin, Webber's agent, said Wednesday. "But what I want to make clear is, Ed Martin has known Chris since he was in the eighth grade. And at that time, Ed Martin was not a Michigan booster.
"I think people are taking all of these allegations and running them together."
The former Michigan and Detroit Country Day star was expected to speak with the media before Wednesday's game against the Detroit Pistons.
Webber told ESPN last weekend "there's no way in the world that I took $280,000 from someone."
The 68-year-old Martin and his wife were arrested March 21 on charges of running an illegal gambling business, conspiracy and money laundering. They pleaded innocent and were released on $10,000 bond each.
During Michigan's own investigation into Martin's activities, Webber cooperated fully and admitted receiving small gifts and meals from Martin, but no violation was found because the player and Martin had a relationship dating to junior high school, Erwin told The Ann Arbor News for a story Wednesday.
But Marvin Krislov, Michigan vice president and general counsel, said he could find no evidence Webber or Erwin ever told Michigan that Webber took anything from Martin.
"Everything we learned, we detailed in the report," Krislov said. "We never heard anything like this from anybody. Webber repeatedly refused to talk to us."
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Dragora Linux 2.0: 100% Free
Dragora, a Linux distro that uses exclusively free software, is available in version 2.0.
Even the embedded Linux-Libre kernel includes no elements that aren't explicitly under a free license. In the new Dragora release, the kernel is version 126.96.36.199.
The Argentine distro uses Runit for system startup. Clzip 1.0 and Lzip 1.0 help in Dragora 2.0 for a fast unpacking of the software package. The developers create the packages from scratch from the upstream sources. The GCC version used is 4.4.3 and OpenSSL is version 1.0.0. The new package also includes the Curl HTTP tool and the Expat parser to supplement Git version control.
The CD installation image for Dragora 2.0 is available for download on the primarily Spanish language homepage.
Think about DragoraIndependent, reliable, powerfull, simple, light, and fast linux.
The most important keypoint is "FROM SCATCH" (like embedded linux).
I hope Dragora will make SERVER edition.
Issue 191/2016
Buy this issue as a PDF
Nextcloud Announces Raspberry Pi-Powered Home Cloud Box
Innovative system adds a hard drive and Ubuntu Core to the RPi for an IoT hub.
Linus Torvalds Confirms the Date of the First Linux Release
Linux is two weeks younger than we thought!
End of OpenOffice?
The Apache Software Foundation considers retiring OpenOffice
Adobe Gives New Life to NPAPI Plugin for Linux
Adobe won't kill the plugin in 2017
LinuxCon North America Convenes in Toronto, Canada
Linux Foundation's big event celebrates the 25th anniversary of Linux
Linux Turns 25
Linux has evolved from "won't be a professional" project to one of the most professional software projects in the history of computers.
Mirantis Joins Hands with SUSE To Offer RHEL Support; Red Hat Not Happy
Competitors get in the game with RHEL without Red Hat
Linux on Windows 10 Poses a Security Risk
Security researchers have already notified Microsoft; some fixes are available
Mirantis to Refactor OpenStack Fuel for Kubernetes
The company is collaborating with Google and Intel to use Kubernetes as an engine for Fuel
Canonical Joins Document Foundation Advisory Board
The upcoming release of LibreOffice will be available as a snap package


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Infrastructure Code Reviews
As infrastructure becomes code, reviewing (and testing) provides the confidence necessary for refactoring and fixing systems. Reviews also help spread consistent best practices throughout an organization and are applicable where testing might require too much scaffolding.
Interview and Book Review of The Technical and Social History of Software Engineering
Capers Jones wrote the book The Technical and Social History of Software Engineering in which he provides an overview of the evolution of information technology and software development. InfoQ interviewed Capers about advancements and events in software engineering and the effects that they have had on our society.
Monty Taylor and Jim Blair on CI and Test Automation at OpenStack
Monty Taylor and James Blair talk about the build and test challenges they face at OpenStack, and how they managed to tackle them. Managing hundreds of VMs on public clouds, integrating up to 400 commits a day and running thousands of test jobs on them are some of the challenges described.