text:
Posted by myfirstadmin | 0 Comments
Kickstarter mud MMO canceled
Normally, he'd be in prayer session now, but his father was off on a diplomatic visit to Stromgarde, and Uther had accompanied him. Which meant that now Arthas had afternoons free for a few days, and he was not about to waste them, even if the weather was less than perfect. He clung easily and familiarly to Invincible as they galloped over the glade, the animal's stride only slightly slowed by a few inches of snow on the ground. He could see his breath and that of the great white horse as Invincible tossed his head and snorted.
A few days before the MMO project voxel-based developer behind mud, it announced that the project had been canceled part way through the fund-raising as the team has provided more lucrative opportunities. Originally earn money before the team went to Kickstarter to begin formal fund-raising activities in the pure state of the game with the "rent", MUD development and release of funds. Unfortunately, the game does not burst out of the gate, and left a $ 50,000 short-term goal of $ 65,000, at the time canceled.
Despite its obvious struggle to achieve its objectives, it is not the reasoning behind Kickstarter cancellation. The development of this Walsh notice posted on Kickstarter page MUD community, the team will move to several other projects and other developers approached the team title position. The team believes this is the best course of action, because it allows them to better collect funds, and plans to later stages of the game.
MUD is an ideal project for us, we need a self-financing, taking the work-for-hire projects. We started Kickstarter, so we can just focus on mud. But during the event, we have contacted several companies to create competition for them. It was a difficult decision, but we have decided to cancel the event and the MUD aside for a moment. While this unfortunately means MUD will take longer to complete, it can help us in the long run, by allowing the growth of our team, there is more money in the future for the MUD.
We've learned a lot doing Kickstarter activities. We have recognized that you, our audience, well, your feedback is very valuable to help us focus on the design. We hope that the MUD is the best game you can, so we take this opportunity to ensure that possible. Once we have enough money, we will go into right back, let MUD best game possible.Read More
Posted by myfirstadmin | 0 Comments
Armored warfare open the door to the masses
Taretha blinked at him. It took a moment for her to understand what he was saying, and then cautious relief and gratitude spread over her face as she poured the wine. After a little while, she began to respond to his questions with more than a few polite words, and they spent the next few hours talking before they agreed it was time for her to return. As she picked up the tray, she turned to him.
My.com and Obsidian Entertainment today announced the upcoming launch of the first open event of the stress test military combat online game, armored warfare. The event, which is open to all interested players, scheduled to begin this weekend on September 24 and continue through until September 25. Opening pressure test event armored war everyone involved will be treated as a unique forum title and be able to experience the content of some of the new works, including new PVE missions and additional PvP map.
The stress test event marks the final phase of obsidian mobile armored warfare toward its beta launch. The first stress test is designed to give developers time to ensure the game is technically ready for a greater number of players, while allowing the community to provide games and stability characteristics of the current state of feedback.Read More
Posted by myfirstadmin | 0 Comments
August EverQuest 2 server consolidation
A chorus of sharp screeches from outside broke Viryx's line of thought. She left the hut, tucking the scroll into her belt. Outcasts were fleeing in all directions. Overhead, something large scrambled through the crimson- and green-leaved canopy.
EverQuest 2 executive producer Holly signaling official "Windstalker" Longdale latest production of what teasing at the forum a couple of months back: EverQuest II will "merge" (do not merge it!) Around the end of this month US servers this month, Russia, Japan and the EU server follow later this year. To merge the server has not been determined, but the dawn is planning to allow players to vote for the new combination, the name of the server.
In addition, Longdale mentioned a new activity is still working, and there was a prelude to the event may suddenly appear in the end of September. Meanwhile, if you want to be a part of community development roundtable valley of Kyle, "Kandel", there is still time to sign up and let your voice.
There are still some surprise, but … Longdale says her team still has "a few things our sleeves," they are "going to try a few ideas."'m Glad to see some innovative MMO try near its 11-year-old birthday.Read More
Posted by myfirstadmin | 0 Comments
HI-REZ STUDIOS announces new free play TITLE "Knight"
Hi Suarez Studios, the team behind the attack, has announced their next game to enter the free play space "Paladin: The Kingdom of the championship" team-based, first-person shooter game combines elements of fantasy card games based on progress to strengthen ability and statistical data. Paladin is now expected to be released PC and current generation consoles.Viryx squeezed the kaliri. The bird chirped in pain, thrashing helplessly in her palm.
"We have succeeded in maintaining the secrecy Paladin more than a year, so the team is really looking forward to the hands-on demo GamesCom receive feedback," Todd Harris, COO of high-tech studio Suarez said. "We are focused on fun and let us find a competitive thing, and soon players will help us craft how Paladin grow from here."
In Paladin, mutual opposition team captures a control point and destroy the enemy base while defending himself. Each battle has entered a major weapon, fighting a fight and athletic ability, and individuals to install quickly carried from a fight next. Players can start every game for the activation and development in leveling the match, and enhance real strength, defense, and practical entire conversation skills cards can be customized platform.Viryx released the kaliri. She pulled her dagger away but kept it in hand. "What do the words mean?"
If you want to go GamesCom you can get some hands-on time with the game, if not, pay for new registration test Paladin site visits, and check out some information on some of the game's heroes. Currently scheduled for release in 2016.Read More
Posted by myfirstadmin | 0 Comments
Are the Pathfinder Online Settlement Mechanics Too Detailed?
It's amazing to see how much mmorpg games have changed since they first burst upon the scene in the late 1990s. Since then, online games have definitely changed course to appeal to a broader base of players. While this definitely made financial sense, gamers that were looking for a greater challenge felt left behind. Fortunately for them, a number of sandbox mmos are being developed, and one of these is Pathfinder Online. I became familiar with this game as I've played the pen-and-paper rpg a few times in the past and was intrigued about an online version. One of the key elements of Pathfinder Online is the creation and use of settlements by players. The developers recently posted a blog entry that dove into some of the mechanics behind this system, and I have to say that it's pretty intricate. Are the Pathfinder Online settlement mechanics too detailed?
Pathfinder Online settlement
Pathfinder Online settlements are the centerpiece of the game's design. What is interesting is that a settlement is more than just a collection of buildings within the online rpg. They are both a place and a social grouping of players. When a player is part of a settlement, that means that they're part of the settlement's ownership and management. To show how important Pathfinder Online settlements are, the structures in said settlement reflects the abilities that a player's character can use as well as the skills that they can train. This also means that characters can lose access to certain abilities if they leave the settlement. The end result is that the use of settlements and the attendant resources needed to fuel them will lead to groups of players engaging in some serious PvP to gain territorial control.
This is a highly interesting system, but I would like to focus a bit on the core mechanics of laying out and building Pathfinder Online settlements. The first Goblin Squad Newsletter put out by the developers delves more deeply into these mechanics, but I must point out that such mechanics are subject to being changed as the game continues to develop. The basic building block for creating settlements is kits with additional crafting components needed, depending upon the structure being built. An example that was given was of a Garrison structure needing a selection of swords, armor, decorative weapons, and books about combat in order to start. Luckily for ambitious builders, the developers provided a handy spreadsheet that includes all the recipes for the new kits.
Buildings in Pathfinder Online settlements come in different sizes, and each settlement only has a limited number of slots. The initial size of a settlement will include two large slots, six medium slots, and ten small slots. Some building examples include auction houses (large), universities (large), war wizard academies (medium), temples (medium), woodshops (small), and libraries (small). So far, so good. I've got a decent handle on creating settlements in the game.
However, the Pathfinder Online settlement system goes into much more detail. Take a gander at this text on development indexes: "Each Settlement has three Development Indexes, which are resource pools that function in a similar fashion to Company Influence but at a Settlement level. Development Index points are gained by controlling hexes via Holdings and building Infrastructure in your Settlement. Development Index points are banked in structures in your Settlement when you build or upgrade, and the banked points are returned when the structure is downgraded or destroyed." It appears that there are three development indexes (security, civilization, and morale), and the max development index of a settlement is based upon the square root of the number of holdings held by companies (guilds) in the settlement times one hundred, plus a bonus for each upgrade applied to one of those holdings.
In case you have a desire to return to math class, there are still more numbers and figures coming our way. Another of the Pathfinder Online features as it pertains to settlements is infrastructure, which are objects that represent an investment in making the settlement a better place, but they are not buildings. An increase in infrastructure increases the development indexes of a settlement. There are multiple levels, each with associated weekly upkeep costs and a bonus to the development index. You can read the entire post on Pathfinder Online settlements here, and one thing you will notice is the inclusion of a few tables and the spreadsheet noted above.
Pathfinder Online tannery
To be honest, when I first started reading the mechanics of settlements within the mmo, my eyes began to glaze over. I'm a simple gamer who just wants to stab bad guys in the throat, steal their stuff, and make some virtual coin in the bargain. Anything that requires me to look at a spreadsheet or use a calculator is way too detailed for my tastes. With that being said, the Pathfinder Online features that I've discussed are quite necessary. As settlements are the core feature of the game, it behooves the developers to create a robust and intricate system to allow gamers the chance to create a settlement of their own design and one that fits their needs. I'm not the core gamer that is being targeted by this mmo (plus, I tend to jump around from game to game due to the nature of my job). Gamers who are eager to leap into the sandbox world of Pathfinder Online don't want a basic system that just scratches the surface or does not require a good deal of planning and effort in order to build and maintain a settlement.
Therefore, the answer to my question of whether the Pathfinder Online settlement mechanics are too detailed is an absolute no. The work done on this system shows that the developers have put a great deal of time and energy into crafting a system that will not only work in its own right but will also satisfy the myriad needs of thousands of gamers and guilds. There are currently 33 player-run settlements in the game, and more will be added over time. What's amazing is the sheer pride that players have in the settlements that they've created, and you can bet that such pride will lead to some fierce conflicts down the road as settlements will eventually vie against other settlements. My preferred style of playing means that I'm not the target audience of Pathfinder Online, and that's totally okay. I love it when a game goes full bore into creating features that their targeted players want to see. It'll be fascinating to see what kingdoms arise from these initial humble settlements.Read More
Posted by myfirstadmin | 0 Comments
Should MMO Companies Concentrate on a Single Game?
A lot of game companies are synonymous with a particular mmo game. Blizzard will always be tied to World of Warcraft, and Jagex will forever be linked with RuneScape. Some companies juggle multiple titles to varying degrees of success whilst other companies focus all of their attention upon a single game. There are concrete and legitimate reasons for either action. The question that we ask today is: should mmo companies concentrate upon a single game?
The thought of a company focusing on a single mmo popped into my head when I read that Hi-Rez Studios recently surprised gamers and industry pundits alike with the announcement of Paladins, their upcoming mmofps. What struck me was that they had quietly worked on the game for over a year, and, in that time, SMITE has rocketed in popularity. I know that Hi-Rez Studios also has Global Agenda in their roster, but that particular mmofps had been put on the backburner as the company poured their resources into SMITE over the last couple of years. One would think that they would continue to focus on SMITE as eSports and moba games continue to massively surge in popularity every single year.
There are both pros and cons for companies concentrating on a single mmo. The main pro is that the game benefits from having all the company's resources poured into it. We do know that a single game company can be wildly successful. The proof of that is Riot Games and their League of Legends. While some may smirk and say that the company should be called Riot Game, nobody is laughing as the moba is generating a billion dollars in revenue. Such massive success is hard to argue with, but one could counter that Riot Games is a one-trick pony. (But, oh, what a pony it is!) Believe me, there are a horde of game companies that would gladly be a one-trick pony like Riot Games.
The drawback to focusing upon a single mmo is what happens if the game fails? There's something to be said for not putting all your eggs in one basket. Just like the stock market, it's always prudent to diversify your portfolio. If a game company puts all their hopes on a single mmo, and that mmo fails, then it's bad news for the company. Blizzard has taken the pragmatic approach as World of Warcraft has had its subscriber numbers drop over the years by developing and releasing other games. Titles like Heroes of the Storm and Hearthstone have added nicely to the company's bottom line. In particular, Hearthstone is generating a cool $20 million a month in revenue, and that number is likely to go up over time.
Some could argue that working on multiple games could dilute the overall product as talent and resources are stretched thin. This is a valid concern, and steps would have to be taken to ensure that any major updates to those games do not compete with one another. The most important criteria on whether a company should focus upon a single mmo is the size of the company itself. Blizzard can afford to have multiple, high-quality games in production at the same time as they have thousands of employees. By contrast, Project Gorgon is being created by a husband-and-wife development team. The zombie mmo Survive the Nights is being developed by a team of five people. A company that has an overabundance of resources and people could devote a considerable amount of energy into multiple titles without worrying about a lack of quality. In comparison, a small company will have to focus their attention upon their lone game in order to maintain a good level of quality and to ensure that the current player base stays engaged with the game.
Overall, I don't think an online game company focusing upon a single mmo is neither good or bad. What matters is the effort and care they put into supporting the game (or games) under their belt. Players can tell when developers are excited about the game that they're working on, and the final product tends to show the quality put into it. A company like Hi-Rez Studios can afford to develop a game like Paladins because the great success of SMITE has allowed them to hire additional people to work on the new product. With that being said, the company should take great pains to ensure that their core game is not negatively impacted by working on multiple titles. CCP has spent several years trying to launch new games based upon their EVE Online setting to varying degrees of success. In the end, as long as a company has the resources to work on multiple mmo games without diluting the quality of any of them, then there's no problem at all.Read More
Posted by myfirstadmin | 0 Comments
It was announced years ago, has jumped developers and publishers, and by and large seems like the sort of thing that was never going to come out. But Otherland is indeed coming out on August 26th. Granted, it's only "coming out" in the sense of an Early Access launch on Steam, but that's still far more than fans of the original novels have likely expected for the past few years.
Otherland is an action MMO offering housing, an "eDNA" system allowing players to copy and clone items, and a variety of different game environments to explore. You can see exactly what the game will play like on the 26th for yourself if the top-level overview has you intrigued, or if you just loved the books and can't wait to see the virtual worlds made… well, not real, but virtually explorable at least.
Read More


text:
The leading center for scholarly reflection within the Catholic moral and intellectual tradition
Director Snead Pens Featured CNN Op-Ed on VP Nominee Kaine
Carter Snead, director of the Notre Dame Center for Ethics and Culture and professor in the Notre Dame Law School, has written a featured op-ed published on CNN's homepage about Democratic Vice-Presidential nominee Tim Kaine. In regards to Kaine's claim that he is personally opposed to abortion but believes that the law ought not restrict it (the "Cuomo argument"), Snead writes, "Kaine's position is essentially that the law should permit and publicly fund what he is personally convinced is the unjust killing of a million innocent human beings each year."
Read Professor Snead's op-ed here.
ND Vita Institute Heads West
On July 22 and 23, the Center for Ethics and Culture presented a special Notre Dame Vita Institute for the Archdiocese of Los Angeles at the invitation of Archbishop José H. Gomez. More than 100 participants from across Southern California took part in the weekend at St. John's Seminary in Camarillo, which was co-sponsored by the Archdiocesan Office of Life, Justice, and Peace. Sessions included presentations on the biological development of the unborn child from his or her earliest stages, legal issues surrounding abortion, physician-assisted suicide, federal policies toward embryonic stem cell research, analysis of popular philosophical arguments in support of abortion, and how to communicate the pro-life message across generations. Participants included nurses, doctors, college professors, priests, religious sisters, parish ministers, and pro-life advocates of all ages.
Read all about the ND Vita Institute: Los Angeles here.
Director Snead Responds to Preliminary Injunction Blocking Implementation of Indiana HB1337
Carter Snead, director of the Notre Dame Center for Ethics and Culture and professor in the Notre Dame Law School, issued a response to Thursday's decision by U.S. District Court Judge Tanya Walton Pratt to issue a preliminary injunction against Indiana House Bill 1337, which prohibits abortion based on a diagnosis of disability, sex, race, or national origin.
Upcoming Events
2016 Football Tailgates
Save the date to join us for food, fellowship, and fun at a Center for Ethics and Culture Tailgate! We'll cheer on the Irish before two home games this year: September 17 (vs. Michigan State) and October 15 (vs. Stanford). We'll see you under the tent!

subset: commoncrawl


text:
go wii!
Is N64 cool? I never played it. Which game consoles do you have? I have a GBA, GBA SP, and PS2. I want a Wii. How about you. What do you have, and what do you want?Originally Posted by SuperH
go wii!
Tiger Woods PGA/NCAA/Madden/Battalion Wars 2/New Resident Evil(when ever that comes out)/Sadden....to name a few
edit// im guessing the 93 in wii4ever93's name is his birth year.
never played a N64? Golden eye was king of its time lol
Hook'em Wii
The Wii is great, but if you're going to bash another console at least have reasons. Otherwise you're just another annoying fanboy that makes the rest of us look bad.
The new cool games are Tony Hawk Downhill Jam and Need for Speed Carbon. The steering with the remote is awesome!Originally Posted by ddslee
yes, the 93 is my birth year. my birthday is 10-10-93Originally Posted by Capt Elmer
i bet im older than you,and ill take on any mario zelda game before any,GTA,50 cent,halo,or any other quick cash in games.
as for me the only thing worth on ps2 was the FF series,draogn quest,castlevania,metal gear,and devil may cry.
as for xbox? none that ill remember playing on other consoles.halo simply does not buy me.just splinter cell series,like every other console.
GC had,soul calibur,metal gear,eternal darkness,metroid prime series,zelda series,mario kart series,kart,party,sunshine,smash brothers,geist,residen evil,splinter cell
"I don't know why I did it, I don't know why I enjoyed it, and I don't know why I'll do it again!"
Where the hell are the mods? does this forum not have mods? this retard should have been banned after his 3rd post..... sigh
Heh, I remember getting Mario Party. Just Mario Party. Not Mario Party 4, Mario Party. In fact, it was the first thing I got for my n64. And of course there was mario 64. Thank you Nintendo for bringing it to the DS for me! And what about Ocarina of time! That was a jewel!
And Thank-you wii4ever93 for stopping your child like behaviour. It makes the forum a much better place!
As for the systems I have. Well, Ill just say what I still have!
Yeah it was cool.Originally Posted by wii4ever93
Here's the consoles I've had in my life, in the order acquired:
1. Mattel Intellivision
2. Atari 400
3. Nintendo (NES)
4. Super Nintendo (SNES)
5. Sega Genesis
6. Sega CD
7. Nintendo 64
8. Playstation 2
9. Gamecube
10. Nintendo Wii
11. Xbox 360
Here's the handhelds I've had in my life:
1. Gameboy (The Brick)
2. Gameboy Advance SP
3. Nintendo DS
Here's the handheld players I've had:
1. Super GameBoy (Play Gameboy games on Super Nintendo)
2. Gameboy Player (Play Gameboy/Gameboy Advance games on Gamecube)
Nintendo 64 was cool, but it is considered to be Nintendo's least successful console. There were great games for it, like Super Mario 64, Conker's Bad Fur Day, Mario Kart 64, and Goldeneye.


text:
Bend It Over LyricsBend it, bend it, bend it over
Go and bust it open
Bend it, bend it, bend it over
Let me see what you working with
Bend it, bend it, bend it over
I wanna see you twerk something
Bend it, bend it, bend it over
Go and let me bless you dear
Bend it, bend it, bend it over
Go and bust it open
Bend it, bend it, bend it over
Let me see what you working with
Bend it, bend it, bend it over
I wanna see you twerk something
Bend it, bend it, bend it over
Go and let me bless you dear
Bend it, bend it, bend it over
We're going, baby,…
I'm tryna see that pink pit, make me feel like it's Easter
I wanna see you bust that
I'mma show love
I ain't looking for nothing free, you know I got my cheese up
I've been tryna get a sneak peek
I'm on good dope, need no sleep
I've been tryna get a one on one
Me and you and you and me
I've been running my checks up
I'm good, baby, don't need no receipt
I need you to bend it over
And make that thang go right at me
Can you make them muscles move?
Make it breathe for me!
Can you make them cheeks jump?
Make them bounce from me!
Can you make that ass clap?
Make it clap for me!
And if you do that one more time
Tell you now, I'mma paint somethin
Talkin bout red bitch
Red pill, red cup, red J
Purple weed, purple drink
I can stare at your ass for days
Black bitch, pink pussy
Little bit of hair on it
Short bitch, fat ass
Watch this stack stand upon it
Whole gang's suped up
Watch her do that crazy shit
She don't want that nigger so she
Pretend she ain't got the pain and shit
Here with all my niggas
And everybody got a different business
Shake what your mamma gave
Matter of fact, that who I'm trying to hit
I can't even move, I snuck before all of this biz
That pussy sitting all right
I'm trying to go off in that business
All the money you made tonight
Is time you throw it all in that business
Pop that pussy for the realist motherfucker off in this bitch
Pussy popping, everything look good
Good pussy alert
I just wanna see if she can take it
Big dick alert
All I got is wads in my pocket
Ain't no wallets, nigga
All I got is sliders in my gear
Ridin solid, nigger
Dranking on shit that people say
Fuck your liver up
Smokin on shit that people say
Cost too fuckin much
Ride around in somethin that cost money
Ain't no Lambo
Told me she don't really like to suck it
I be damned, ho!
I'mma fall back and play my part
Let you twerk it for me
I'mma grab your hand and put it on it
Lets just stroke it for me
Hands on your knees, face up
Go on, bend it over!
I'mma get behind you
Beat it good, come here
Let me show you!
Si les paroles de 'Bend It Over' contiennent des erreurs, laisse nous un commentaire. On fera le maximum pour les corriger dans les plus brefs délais.


text:
Des Moines Register/Selzer & Co. Iowa 2016 Democratic Caucus Poll
Favorable / Unfavorable {Net}
- Hillary Clinton 89% / 7% {+82%}
- Joe Biden 71% / 18% {+53%}
- Martin O'Malley 18% / 13% {+5%}
- Brian Schweitzer 16% / 14% {+2%}
Survey of Democratic adults was conducted December 8-11, 2013. The margin of error is +/- 8 percentage points.
–Data compilation and analysis courtesy of The Argo Journal
I guess the Christie fans here didn't want to post the republican poll which has Christie with highest unfavorable rating from Iowa republicans. And this poll is before most of them know how liberal Christie really is.
Iowa Republicans very well know how "liberal" Christie really is, which is why he has the unfavorables he has and isn't polling as well as he is in other states. With that said, he's still holding up pretty well. Not like he needs Iowa anyway. Santorum won it in 2012, and Huckabee won it in 2008.
From the Wickers Group:
Iowa GOP Caucus
Mike Huckabee 21%
Chris Christie 14%
Ted Cruz 14%
Rand Paul 11%
Marco Rubio 9%
Rick Perry 5%


text:
Smoked Salmon Mousse & Strawberry Shortcake Pancakes
Today's Delicious Links• Easy Appetizer – Smoked Salmon Mousse - At A Food Centric Life. • Fried Tofu with Peanut Sauce - At Rachel Cooks Thai. • Stacked Up - Strawberry Shortcake Pancakes - At Good Food, Good Wine, and a Bad Girl. • "Upside-Down" Tonnino Jalapeño Tuna Taco Bites - At Food Wishes.
Found a new product? Made a great recipe? Have a delicious link to share?
Send us a tip!
Send us a tip!
Previous Delicious Links


text:
It's time for Isaiah to decide where he'll play in his fifth season. Will he stay in Carolina? Or will he land his plane in a new location? Find out where Isaiah's career takes place in Madden 16! More Madden 16 Career Mode: http://bit.ly/M16CareerMode Playlists: ● Madden 16 RB Career …Read More »
Madden 16 S5 Career Mode: FREE AGENCY Decision!
It's time for Isaiah to decide where he'll play in his fifth season. Will he stay in Car...
Assassin's Creed Syndicate Walkthrough Part 1 – The Beginning!
Follow along & watch the story of Assassin's Creed Syndicate in my gameplay walkthrough! T...
Madden 16 S2 Career Mode: Isaiah SHREDS Chiefs + Best Run of His Career!
In Madden 16's Career Mode, Isaiah King goes up against the Kansas City Chiefs and absolutely ...
NBA 2K16: How to Eurostep & Other Advanced Moves
In NBA 2K16, the control scheme is pretty advanced. In this tutorial, I'll show you how to eur...
NBA 2K16: How to Throw Alley-Oops | How to Run Pick & Rolls
The controls have changed in NBA 2K16, so I'm teaching you how to throw alley-oops in NBA 2K16...
Latest Content
10 Things You'll LOVE About Black Ops 3
It's almost time to get your hands on Call of Duty: Black Ops 3. The game is packing a ton of content from Zombies, Nuketown 2065, multiplayer & even more. Check out this countdown for 10 things you'll love about Black Ops 3 leading up to its release! Enjoyed the …Read More »
Madden 16 S2 Career Mode: TRICK Plays + Final Regular Season Game!
After a rough season with his teammates getting injured in Madden 16's career mode, Isaiah tries to secure a Divisional round playoff berth. Will some new trick plays in their playbook be enough for the Panthers to win the NFC South? Playlists: ● Madden 16 RB Career Mode: http://bit.ly/M16CareerMode ● …Read More »
Assassin's Creed Syndicate Walkthrough Part 1 – The Beginning!
Follow along & watch the story of Assassin's Creed Syndicate in my gameplay walkthrough! The two main characters of the game are Jacob Frye & Evie Frye, a brother & sister duo. Assassin's Creed Syndicate is actually the first time you can switch freely between two different characters, and it's …Read More »
NCAA Football 14 – S2 Road to Glory – Pushing for the Heisman!
After being snubbed in the Heisman voting early in his sophomore season in NCAA Football, Isaiah needs a big game to jump back into the race. Can he muster enough yards against a strong Notre Dame defense? Playlists: ● Madden 16 RB Career Mode: http://bit.ly/M16CareerMode ● MLB 15 RTTS Playlist: …Read More »
Madden NFL 16: How to Create Ezekiel Elliott
Learn how to create Ezekiel Elliott from the Ohio State University in Madden NFL 16! Find out Ezekiel's ratings, equipment, and player info to use in Madden. If Ezekiel Elliott declares for the 2016 NFL Draft, he'll likely be one of the top running backs taken. He possesses great vision, …Read More »
NBA 2K16 My Career: FREE AGENCY Choices
In NBA 2K16's My Career mode, Kendall King finishes his rookie season & enters free agency. Help choose where Kendall will end up for his second season. Will he stay with the Miami Heat? Or will he find himself in a new area code? What team do you think Kendall …Read More »
Madden 16 Ultimate Team – Ep 3 – Opponent RAGES + Draft Champions Super Bowl!
In Madden 16's Ultimate Team, I make an opponent rage quit thanks to Tyrod Taylor & Lamar Miller. After that, I try to win the Super Bowl in Draft Champions against a TOUGH opponent! Can I manage to pull out the victory in Madden 16's Draft Champions mode after a …Read More »


text:
Author Affiliations: Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
Background Although several new antithrombotic agents have been developed for stroke prevention in patients with nonvalvular atrial fibrillation (AF), many patients will continue to be treated with warfarin worldwide. We performed a meta-analysis of safety and efficacy outcomes in patients with AF treated with warfarin for stroke prevention in large contemporary randomized controlled trials (RCTs).
Methods We searched the MEDLINE, EMBASE, and Cochrane databases for relevant studies; RCTs comparing warfarin with an alternative thromboprophylaxis strategy with at least 400 patients in the warfarin arm and reporting stroke as an efficacy outcome were included.
Results Eight RCTs with 55 789 patient-years of warfarin therapy follow-up were included. Overall time spent in the therapeutic range was 55% to 68%. The annual incidence of stroke or systemic embolism in patients with AF taking warfarin was estimated to be 1.66% (95% CI, 1.41%-1.91%). Major bleeding rates varied from 1.40% to 3.40% per year across the studies. The risk of stroke per year was significantly higher in elderly patients (2.27%), female patients (2.12%), patients with a history of stroke (2.64%), and patients reporting no previous exposure to vitamin K antagonists (1.96%). There was a significant increase in the annual incidence of stroke with progressively increasing CHADS2 (congestive heart failure, hypertension, age, diabetes, and prior stroke) scores.
Conclusions Current use of warfarin as a stroke prevention agent in patients with AF is associated with a low rate of residual stroke or systemic embolism estimated to be 1.66% per year. Compared with a previous meta-analysis, there has been significant improvement in the proportion of time spent in therapeutic anticoagulation, with a resultant decline in observed stroke rates.
Quiz Ref IDNonvalvular atrial fibrillation (AF) is associated with a 5-fold increase in the risk of ischemic stroke and has been implicated as a causal factor in as many as 15% to 20% of all ischemic strokes.1 A meta-analysis2 of 6 randomized controlled trials (RCTs) comparing the efficacy of warfarin with that of placebo in stroke prevention in AF demonstrated a significant reduction in stroke andall-cause mortality in patients treated with warfarin compared with no antithrombotic treatment. Patients with AF at the highest risk of stroke, particularly those with previous stroke or transient ischemic attack (TIA), derived the greatest absolute risk reduction with warfarin compared with aspirin or no antithrombotic treatment.2 Although a more recent meta-analysis3 evaluating the efficacy of available antithrombotic therapies for patients with AF included 29 RCTs, no new trials comparing warfarin with placebo were available for inclusion.
Novel antithrombotic agents have been developed as alternatives to warfarin (eg, direct thrombin inhibitors4- 6 and selective factor Xa inhibitors7- 9), several of which have been demonstrated to be superior to warfarin in clinical trials.6,8,9 In addition to therapeutic efficacy, these newer agents are easy to administer, are consistent in effect, and lack interaction with other medications and dietary agents. Initial utilization of these agents may, however, be hampered by cost. Consequently, despite its proven inadequacies and the need for close laboratory supervision, we expect treatment with warfarin to continue as the dominant therapy for patients with AF, especially in the setting of limited financial resources. Physicians may also delay using these promising newer agents in their patients as they await safety data in the "real world." Furthermore, there have been significant advances in warfarin utilization for primary and secondary stroke prevention in patients with AF, including the use of target international normalized ratio (INR), INR monitoring routines, increased physician emphasis on compliance, and a better understanding of genetic and environmental interactions.10,11
Faced with these newer choices, it is imperative that physicians precisely estimate the inherent bleeding risk accompanying warfarin treatment in eligible candidates with nonvalvular AF using current data over historical rates obtained in the previous decade. To this end, we conducted a contemporary meta-analysis of recent RCTs comparing warfarin with an alternative antithrombotic therapy for stroke prevention in patients with AF with the goal of determining the absolute safety and efficacy of warfarin treatment in AF. This analysis will potentially provide physicians with the best current estimate of the risks and benefits of this treatment in their individual patients. These results could potentially aid the decision process for warfarin therapy for individual physicians and allow health systems to evaluate the cost efficacy of adopting newer agents universally or in specific high-risk clinical subsets.
We evaluated all RCTs reporting the safety and efficacy of warfarin therapy in patients with nonvalvular AF published in the English language during the past 10 years (2001-2011). Trials were included if they compared warfarin with an alternative antithrombotic regimen for primary or secondary stroke prevention in patients with nonvalvular AF. The studies included for meta-analysis were restricted to high-quality trials (Jadad score ≥3) including at least 400 patients with AF in the warfarin arm.12 This cutoff point of 400 patients was established a priori to restrict the meta-analysis to robust and large clinical trials only, enabling accurate assessment of event rates. The Jadad score is a validated method for assessing the methodological quality of RCTs based on randomization strategy, blinding, and withdrawals and dropouts.12
A computerized literature search of the MEDLINE, EMBASE, and Cochrane databases was conducted using Medical Subject Headings and keywords such as warfarin, vitamin K antagonists, atrial fibrillation, and atrial arrhythmias coupled with outcomes searched using terms such as stroke, cerebrovascular accident, transient ischemic attack, and TIA.
The primary efficacy outcome was defined as the occurrence of ischemic or hemorrhagic stroke or non–central nervous system (non-CNS) embolism. Secondary efficacy end points were studied using pooled analysis and included myocardial infarction (MI), all-cause mortality, and composite adverse vascular events (including stroke, non-CNS embolism, MI, and death). Safety outcomes included major bleeding, intracranial hemorrhage, clinically relevant nonmajor bleeding, and minor bleeding. The definition of major bleeding varied considerably across included studies; hence, a valid pooled estimate could not be calculated. In addition to the safety and efficacy outcomes noted previously herein, we also studied the net clinical benefit, which was mentioned in 5 of the included trials.5,6,9,13,14 The net clinical benefit outcome has been defined as major adverse vascular events (including stroke, systemic embolism, and MI), death, or major bleeding episodes. In the context of the present meta-analysis aiming to calculate absolute event rates without a comparison group, the term net clinical benefit seems to be a misnomer. We, therefore, refer to it as the cumulative adverse event rate to estimate the additive thromboembolic event rate, which was not prevented by warfarin therapy, and the major bleeding rate, which occurred as a result of warfarin therapy.
One of us (S.A.) reviewed all the titles and their abstracts selected using the search strategy and retrieved full-text articles for all potentially relevant studies. The full-text articles were subsequently reviewed with a primary focus on inclusion criteria, study outcomes, and methodological quality. If the clinical trial met the inclusion criteria based on these 3 characteristics, it was included in the analysis. The data from the study were then extracted using predesigned structured forms. Completed forms were reviewed by one of us (V.M.) for accuracy and validity. Disagreements, if any, were resolved by the mutual consensus of all 3 of us. After the data elements were verified for accuracy, they were subsequently entered into statistical software for further analysis.
Statistical analysis was conducted using the metan function in STATA, version 10.0 (StataCorp LP). The meta-analysis has been reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.15 Due to a relatively small proportion of primary events in each study, the data were assumed to follow a Poisson distribution. For each study, a 95% CI estimate for the respective outcome was computed using standard Poisson tables. Pooled event rates (expressed as percentage per year) for the safety and efficacy outcomes in the warfarin arm were calculated using standard methods. Fixed-effects modeling was primarily used to conduct outcomes meta-analysis from included studies. Random-effects modeling was used in the case of statistically significant heterogeneity.
Assessment of heterogeneity was achieved by comparing the inclusion and exclusion criteria and the minor differences in the design and conduct of the clinical trials. We assessed for heterogeneity using the I2 test (I2 > 50% with P < .05 implies significant heterogeneity). In cases of significant heterogeneity, the heterogeneity was first explored in the studies, and subsequently a random-effects meta-analysis was performed to statistically account for the heterogeneity. Publication bias was assessed using the funnel plot method and Begg and Mazumdar rank correlation testing.16
Subgroup analyses were performed to determine event rates in different strata of the study population. All the subgroup analyses were prespecified. All the P values were 2-tailed, with statistical significance specified at P < .05 and CIs computed at the 95% level.
Eight RCTs including 32 053 patients were included in the meta-analysis. The pooled analysis yielded 55 789 patient-years of follow-up. The characteristics of the included trials are given in Table 1. There were minor differences in the inclusion criteria, primary safety end point, and efficacy outcomes across the trials. The flow diagram for study selection is depicted in Figure 1.
Figure 1. Flow diagram showing selection of the studies for the meta-analysis.
The comparison group for the warfarin arm consisted of ximelagatran in 2 trials (Stroke Prevention Using an Oral Thrombin Inhibitor in Atrial Fibrillation [SPORTIF] III5 and SPORTIF V]4) and the following drugs in 1 trial each idraparinux (Amadeus7), aspirin (Birmingham Atrial Fibrillation Treatment of the Aged [BAFTA]13), aspirin along with clopidogrel (Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE W]14), dabigatran (Randomized Evaluation of Long-term Anticoagulant Therapy [RE-LY]6), rivoraxaban (ROCKET-AF [ Rivaroxaban Once Daily Oral Direct Factor Xa Inhibitor Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation]8), and apixaban (ARISTOTLE [Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation]9). The characteristics of included patients in the warfarin arm of each trial are given in Table 2. We observed significant heterogeneity in the baseline characteristics of included individuals across various trials. The proportion of patients with CHADS2 scores greater than 2, implying a significantly higher risk of stroke, varied from 28% in the Amadeus trial7 to 87% in the ROCKET-AF trial.8 Similarly, the proportion of patients with exposure to vitamin K antagonists before enrollment in the trial varied from 39.8% in the BAFTA trial13 to 85% in the SPORTIF V trial.4Figure 2 demonstrates that the percentage of the trial spent in therapeutic INR varied from 55% in the ROCKET-AF trial8 to 68% in the SPORTIF V trial.4
Figure 2. Bar graph demonstrating the proportion of time spent in therapeutic anticoagulation across the included studies. INR indicates international normalized ratio. See the "Results" section for expansions of the study names.
Table 3 demonstrates the event rates of efficacy outcomes in the warfarin arm across the included trials. Quiz Ref IDThe rate of stroke or non-CNS embolism varied from 1.2% to 2.3% per year. Similarly, the rates of MI, all-cause mortality, and composite outcomes varied from 0.53% to 1.4% per year, 2.21% to 8.00% per year, and 3.93% to 5.90% per year, respectively. The pooled analysis of safety outcomes is demonstrated in Figure 3. The pooled event rate (95% CI) for stroke or non-CNS embolism was calculated to be 1.66% (1.41%-1.91%) per year. Similarly, the pooled event rates (95% CIs) for MI, all-cause mortality, and composite outcomes were calculated to be 0.76% (0.57%-0.96%) per year, 3.83% (3.07%-4.58%) per year, and 4.80% (4.22%-5.38%) per year, respectively. Analysis of publication bias using the funnel plot method and the Begg and Mazumdar rank correlation method did not reveal any significant publication bias in the reporting of efficacy outcomes examined in the meta-analysis.16
Figure 3. Forest plots demonstrating pooled estimates of safety outcomes. All the estimates were derived from random-effects modeling. A, Stroke or non–central nervous system embolism. B, Myocardial infarction. C, All-cause mortality. D, Composite outcome. See the "Results" section for expansions of the study names. Diamonds indicate the overall summary estimate for the analysis (width of the diamond represents the 95% CI).
The definition of major and minor bleeding varied considerably across the included studies; hence, a valid pooled estimate for these outcomes could not be calculated. Quiz Ref IDThe incidence of major bleeding episodes ranged from 1.40% to 3.40% per year. The safety outcomes in the warfarin arm across the included trials are summarized in Table 3. The annual rate of intracranial hemorrhage in patients with AF taking warfarin ranged from 0.33% to 0.80% per year. Meta-analysis of intracranial hemorrhage yielded a pooled event rate of 0.61% (95% CI, 0.48%-0.73%) per year. The cumulative adverse event rate, defined as major vascular events reported or death or major bleeding episodes, was observed to range from 3.00% per year in the BAFTA trial13 to 7.64% per year in the RE-LY trial.6 Significant variation in the definition of the cumulative adverse event rate across the studies precluded a valid pooled meta-analysis.
Table 4 demonstrates the event rates for stroke and non-CNS embolism in patients treated with warfarin across the included trials, stratified by prespecified subgroups. There was a significantly higher incidence of stroke or non-CNS embolism in patients 75 years and older (n = 6398; 2.27% per year) compared with those younger than 75 years (n = 10 252; 1.62% per year; P < .001). In addition, we observed a significantly higher pooled incidence of stroke or non-CNS embolism in females (n = 8419) compared with in males (n = 14 262; P < .001) and in patients with a history of stroke or TIA compared with in patients without previous cerebrovascular events (P = .001). Patients with no history of exposure to vitamin K antagonists (n = 9925) had a significantly higher incidence of stroke or non-CNS embolism compared with patients who reported use of vitamin K antagonists at the time of enrollment (n = 12 756; relative risk, 1.16; 95% CI, 1.01-1.33). Meta-analysis of stroke or non-CNS embolism stratified by CHADS2 score yielded pooled annual event rates (95% CIs) of 0.89% (0.66%-1.13%) per year for scores of 1 or less (n = 5851), 1.43% (1.19%-1.66%) per year for scores of 2 (n = 7157), and 2.50% (2.17%-2.82%) per year for scores of 3 or greater (n = 11 660). Compared with the lowest-risk category (CHADS2 score ≤1), the relative risk of stroke or non-CNS embolism was significantly higher in the intermediate-risk category (CHADS2 score of 2) (relative risk, 1.46; 95% CI, 1.13-1.89; P = .004) and in the high-risk category (CHADS2 score ≥3) (relative risk, 2.89; 95% CI, 2.28-3.66; P < .001).
Table 5 provides the summary statistics obtained from the studies included in the previous meta-analysis examining trials from 1989 to 1993 that evaluated the efficacy and safety of warfarin compared with placebo.2,17- 22 Meta-analysis of stroke or systemic embolism events across these earlier studies yielded a pooled event rate of 2.09% per year. This was a considerably higher estimate compared with the incidence rate of stroke observed in the present meta-analysis. There was significant variation in the target INR range observed in the earlier clinical trials. The lower limit of the target INR range was less than 2.0 in the Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF)17 and the Stroke Prevention in Nonrheumatic Atrial Fibrillation (SPINAF)18 trials. In addition, there was significant variation in the proportion of time in the target INR range. Only 2 clinical trials (BAATAF17 and Stroke Prevention in Atrial Fibrillation [SPAF]19) had 60% or greater values in the target INR range. In comparison, the clinical trials included in the present meta-analysis have a uniform target INR range (2.0-3.0), with 7 of 8 trials having greater than 60% of INR values in the target therapeutic range.
The present meta-analysis takes advantage of a large body of contemporary evidence to evaluate the efficacy and safety of warfarin therapy in patients with nonvalvular AF treated with warfarin. Quiz Ref IDUsing a database of more than 30 000 patients, the pooled annual incidence rate of stroke or non-CNS embolism was estimated to be 1.66%, considerably lower than the 2.09% in a previous meta-analysis. Due to nonstandardized definitions, rates of major bleeding events ranged from 1.40% to 3.40% per year. Quiz Ref IDSubgroup analyses demonstrated a significantly increased risk of thromboembolic complications in females, in patients 75 years and older, in patients with previous stroke or TIA, and in patients with no previous exposure to vitamin K antagonists. Stratifying the study population by CHADS2 score, event rates for stroke or non-CNS embolism were estimated to be 0.89% per year for the low-risk (score ≤1), 1.43% per year for the intermediate-risk (score of 2), and 2.50% per year for the high-risk (score ≥3) categories. We observed a significantly higher risk of thromboembolic events in warfarin-treated patients with intermediate risk (1.43% per year) or high risk (2.50% per year) than in patients at low risk for stroke (0.89% per year).
Warfarin has been a pharmacotherapeutic standard for stroke prevention in AF; its efficacy for stroke prevention has been demonstrated in patients with AF, particularly those with a high baseline risk of stroke (eg, older age groups).23- 25 In a previous meta-analysis,2 dose-adjusted warfarin therapy was shown to reduce the risk of stroke by 62% and the risk of death by 25% compared with placebo. Several model-based studies have shown warfarin to be an extremely cost-effective strategy for stroke prevention, especially in patients older than 75 years.26 Gage et al23 concluded that the use of warfarin in patients with nonvalvular AF with 1 or more risk factors for stroke was appropriate and cost-effective, with treatment costing approximately $8000 per quality-adjusted life-year saved. Even after consideration of the costs associated with regular INR testing, in most settings, the overall cost of therapeutic strategies using these newer agents will exceed the costs of comparative strategies incorporating generic warfarin. Thus, despite the development of newer antithrombotic agents with increased ease of administration that are superior or noninferior to warfarin,6,8,9 most patients with nonvalvular AF will probably continue to be treated with warfarin in the near future owing to cost considerations. Indeed, warfarin will likely continue to be widely used as the drug of choice in several countries around the world.
The clinical and cost-related outcomes associated with warfarin therapy depend on the duration of therapeutic anticoagulation (indicating the quality of anticoagulation) and rates of warfarin discontinuation.27 We observed a significant overall decline in thromboembolic event rates with warfarin therapy compared with that previously reported in a meta-analysis that compared rates on warfarin with placebo. This decline in event rate is likely due to the increased rates of therapeutic anticoagulation observed in recent studies. Although far from perfect, the proportion of time spent in therapeutic anticoagulation ranged from 55% to 68% across the recent clinical trials, with patients in 7 of 8 trials being therapeutically anticoagulated more than 60% of the time. In addition, the reduction in the stroke rates may be partially attributable to a significant improvement in the management of atherosclerotic risk factors, such as hypertension and dyslipidemia.28,29
This meta-analysis attempted to summarize a large body of contemporary evidence derived from RCT data. The large number of patients included in this meta-analysis increases the strength, validity, and generalizability of the results. By limiting the analysis to results from RCTs, we were able to estimate event rates in a subset of the AF population that has no contraindications to newer antithrombotic agents. These estimates are potentially useful because with expansion of the population eligible for the newer agents in the near future, physicians are going to be faced with the issue of conveying absolute safety and efficacy of warfarin to their patients, especially in resource-constrained settings.
Potential limitations stem from the substantial heterogeneity encountered in multiple comparisons. In our opinion, the significant heterogeneity is a reflection of varying event rates in different settings and populations rather than a profound limitation of the study per se. The cumulative event rate reported, therefore, provides a more reliable event rate than that reported in individual trials.
In conclusion, use of warfarin as a stroke prevention strategy in patients with nonvalvular AF is associated with a low risk of stroke or non-CNS embolism, estimated to be 1.66% per year. Besides thromboembolic events, the pooled incidences of MI, death, and composite outcome were estimated to be 0.76%, 3.83%, and 4.80% per year, respectively. Although there was significant heterogeneity in the definition of bleeding outcomes across studies, the rates of major bleeding ranged from 1.40% to 3.40% per year. We noted a progressive increase in the incidence of stroke with increasing CHADS2 score. In addition, age 75 years and older, female sex, previous stroke or TIA, and lack of exposure to oral vitamin K antagonists were associated with higher risk of thromboembolism with warfarin use.
There has been a significant reduction in the stroke event rate with warfarin treatment during the past 2 decades. This reduction may be secondary to a considerable improvement in the quality of anticoagulation as reflected by a greater proportion of time spent in therapeutic anticoagulation.
Correspondence: Venu Menon, MD, Coronary Intensive Care Unit, Cleveland Clinic, 9500 Euclid Ave, Desk J 1-5, Cleveland, OH 44195 (firstname.lastname@example.com).
Accepted for Publication: January 11, 2012.
Published Online: March 26, 2012. doi:10.1001/archinternmed.2012 .121
Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Hachamovitch and Menon. Acquisition of data: Agarwal. Analysis and interpretation of data: Agarwal, Hachamovitch, and Menon. Drafting of the manuscript: Agarwal, Hachamovitch, and Menon. Critical revision of the manuscript for important intellectual content: Agarwal, Hachamovitch, and Menon. Statistical analysis: Agarwal. Administrative, technical, and material support: Hachamovitch and Menon. Study supervision: Hachamovitch and Menon.
Financial Disclosure: None reported.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers' bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Assessing the Strength of Recommendations: The GRADE Approach
Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3rd ed
Are the Results Valid?
All results at
JAMAevidence.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Need assistance?
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.


text:
Scott Clifton
Television Actor + Musician + Internet Personality.
Born Oct 31, 1984
Scott Clifton Snyder, better known as Scott Clifton, is an American actor, musician, and video blogger. His early work has included television commercials and minor film and television roles, but his most recognized achievements have come from his highly… Read More
View newly released photos of Scott Clifton.
News + Updates
Browse recent news and stories about Scott Clifton.
My Top 10 Daytime Emmy PhotosCNN - Jun 17, 2013
Dust Storm Moves Through PhoenixCNN - Aug 12, 2012
Beautiful, Trama Puntata Del 31 Agosto Teleblog (Blog)Google News - Aug 31, 2011
Beautiful, Trama Puntata Del 29 Agosto Teleblog (Blog)Google News - Aug 29, 2011
Learn about the memorable moments in the evolution of Scott Clifton.
1984 Birth Born on October 31, 1984.
2011 26 Years Old 1 More Event
His role in The Bold and the Beautiful earned him a Daytime Emmy Award in 2011 and 2013. … Read More
2012 27 Years Old Clifton married his longtime girlfriend Nicole Lampson on Saturday, October 20, 2012. … Read More
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Scott_Clifton.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


text:
- Table View
- List View
The Well-Crafted Argument: A Guide and Readerby Fred D. White Simone J. Billings
The Well-Crafted Argument equips students with a comprehensive set of skills necessary for writing argumentative essays in a wide variety of contemporary social contexts. Based on a process pedagogy that encourages individual voice and vision, the book introduces models of good writing for inexperienced writers. Divided into two parts, a rhetoric and a reader, it provides instructors and students with a wealth of materials and tools for effective argumentative writing, thinking, and reading.
The Well-Crafted Argument: A Guide and Reader (4th Edition)by Fred D. White Simone J. Billings
Incorporating new articles, expanded commentary, and the latest changes from the 2009 MLA Handbook and 2009 APA Publication Manual, the 4th Edition of THE WELL-CRAFTED ARGUMENT guides students through the process of writing effective arguments across the disciplines. The two-part structure of this rhetoric/reader includes a complete pedagogical apparatus--with coverage of critical reading strategies, as well as writing, researching, and documenting a topic--and an anthology of readings grouped into nine thematic clusters. In-depth instruction, combined with real student writings, engages students and helps them discover their own voices. The Fourth Edition continues the visual emphasis from the 3rd Edition, while maintaining the authors' practical, skill-building approach. Each chapter in Part I ends with a "Summary," "Checklist," and "Writing Projects," while each cluster in Part II ends with "Connections Among the Clusters," "Writing Projects," and "Suggestions for Further Reading. " These sections encourage students to apply what they've learned and go beyond the classroom if a topic is of particular interest to them. In addition to guidance on drafting and revising arguments, the authors provide a variety of composition strategies, including freewriting, outlining, and shared reading.
Select your format based upon: 1) how you want to read your book, and 2) compatibility with your reading tool. To learn more about using Bookshare with your device, visit the Help Center.
Here is an overview of the specialized formats that Bookshare offers its members with links that go to the Help Center for more information.
- Bookshare Web Reader - a customized reading tool for Bookshare members offering all the features of DAISY with a single click of the "Read Now" link.
- DAISY (Digital Accessible Information System) - a digital book file format. DAISY books from Bookshare are DAISY 3.0 text files that work with just about every type of access technology that reads text. Books that contain images will have the download option of 'DAISY Text with Images'.
- BRF (Braille Refreshable Format) - digital Braille for use with refreshable Braille devices and Braille embossers.
- MP3 (Mpeg audio layer 3) - Provides audio only with no text. These books are created with a text-to-speech engine and spoken by Kendra, a high quality synthetic voice from Ivona. Any device that supports MP3 playback is compatible.
- DAISY Audio - Similar to the Daisy 3.0 option above; however, this option uses MP3 files created with our text-to-speech engine that utilizes Ivonas Kendra voice. This format will work with Daisy Audio compatible players such as Victor Reader Stream and Read2Go.


text:
12 posts tagged with interview and business.
Displaying 1 through 12 of 12. Subscribe:
Please help me get dressed for my interview!
I am going in for an interview at the place I am currently temping. What should I wear? [more inside]
How do you interview for a Company Representative?
I have a meeting with an overseas company, to discuss their need for an east coast representative. They are expanding. It is a high-end, energy efficient product. I have some knowledge in the area, and the product, but more as a consumer, never as a rep, (with ANYONE) We have worked together a bit, but this would be a new role, relationship. I need some clues on how this might go; how might it be structured? what will they expect? how is compensation figured? I am inclined toward keeping my mouth shut, listening, and asking a few relevant questions. Interview hints 101.
I promise I'm actually a good employee!
I have an upcoming job interview for a fairly sales-oriented position in business. Putting aside that I'm not sure I want the position yet and that in my eyes it counts against the company that they put stock in this sort of thing, the company is about to send me a personality test which they use as a strong hiring indicator. I would prefer to ace the test, whatever that means, and have my actual interview and position discussion determine hiring. How should I go about answering a test that I don't believe will be reflective of my personality? [more inside]
Any helpful hints/tips to guide me in my meeting with a club manager regarding events I would like to throw?
I have a meeting tomorrow with an university club manager regarding events that I would like to throw. I have never done this before - any tips/tricks on what I should bring, what I should have prepared and how to negotiate the best pay for me? [more inside]
Business card trading deficit?
What is the etiquette regarding business card exchanges during an interview? When I have gone on interviews in the past, the various people who have interviewed me have given me their business cards. I am never sure whether to give the interviewer one of my business cards in exchange. [more inside]
Business casual or suit to interview?
Business casual or suit to interview? More inside...not as black and white as one would think. [more inside]
Where to get custom made suit in Bay Area?
Recommend a tailor in the Bay Area to create a custom made suit. [more inside]
Freaky Management Friday: Former Boss Edition
Being interviewed by outgoing manager for his/her job. Complex management question inside. [more inside]
First time traveling for an job interview
I am soon traveling for an job interview for the first time, and in general this is the first time i have traveled for "business", any tips? primarily looking for tips about traveling for an interview but if you have a good lesser known tip about interviews, let me have it. [more inside]
Remember the NPR interview about the book on a Chinese businessman?
Help me find a book about a Chinese businessman mentioned on NPR for my Dad! [more inside]
Suit me up
Los Angeles Interview Suit— I need to find something cheap for interviews after finding my last suit had irreperable moth holes in the pants (yeah, you can tell that my last couple of jobs haven't really required dap to the tap sartorial sense). Where in the LA area can I get a cheap (nice) suit fairly quickly? [more inside]
How to handle a phone interview
I recently had a terrific first interview for a position at a very nice four-star hotel. I'm scheduled for a follow-up phone interview in a few days during which I will be asked a few "general business questions about my background". What sort of questions should I expect? [more inside]
Page: 1


text:
NCAA Football
Baylor Bears at Oklahoma State Cowboys Football
This game has turned out to be very important in the Big 12, since Oklahoma State took care of Texas last weekend. Now the winner of today's game will be at the top of the Big 12, with a great chance to finish there. Baylor also has an outside chance of making the National Championship game, and a good showing in this one, would go a long way to helping their case. Baylor has one of the best offenses in the country and a really impressive defense to go with it, but Oklahoma State isn't too far behind, so fans should get a great game.
Venue Information
- Boone Pickens Stadium
- 136 Athletics Center
- Stillwater OK 74076
More Details
Released - Saturday, November 23 , 2013 at 8:00 PM Local Time
Official Website
TV Network - ABC
Official Website
TV Network - ABC


text:
Posts tagged "Bradley Manning"
Censored 2014 is on sale TODAY! Want to know the most underreported news stories of 2012-13?
October 1, 2013
How did you celebrate Banned Books Week last week?
Unfortunately, media and literary censorship is an issue facing US citizens every week of the year. Project Censored has been fighting since 1976 to bring attention to news stories that have been ignored or under-reported in the mainstream media.
TODAY is the release of Project Censored's Censored 2014, featuring the annual list of the top 25 under-reported news stories.
Each year, over 200 faculty members, students, and community experts review hundreds of story submissions for coverage, content, reliability of sources, and national significance. The top twenty-five stories are submitted to a panel of judges who then rank them in order of importance. Current and former judges include Michael Parenti, Cynthia McKinney, Howard Zinn, and Noam Chomsky. The twenty-five stories in this year's edition are clustered by topic in order to provide greater context, with the first and most important topic focusing on past and present whistle blowers and their role in keeping the public informed.
Tags: Banned Books Week, Barbara Jones, Bradley Manning, censored 2014, Freedom to Read Foundation, Lane Tech, Office for Intellectual Freedom, On the Perks of Being a Wallflower, project censored, Project Censored Show


text:
Bills signed OLB Quentin Groves, formerly of the Titans.
Titans signed OLB Quentin Groves.
Texans released OLB Quentin Groves.
Texans signed OLB Quentin Groves.
Free agent OLB Quentin Groves worked out for the Jets on Monday.
Free agents OLB Quentin Groves and LB Marvin Mitchell worked out for the Titans on Tuesday.
Free agent OLB Quentin Groves visited the Patriots on Wednesday, and will visit the Redskins on Thursday.
Browns released OLB Quentin Groves and LB Larry Grant.
Browns placed OLB Quentin Groves (ankle) on injured reserve, ending his season.
Browns OLB Quentin Groves is out 4-6 weeks with a high left ankle sprain.
Browns OLB Quentin Groves (ankle) will not play in Sunday's Week 3 game against the Vikings.
Browns OLB Quentin Groves left Sunday's Week 2 loss to the Ravens early with an ankle injury.
Browns OLB Quentin Groves has been arrested for solicitation of a prostitute.
Browns agreed to terms on a two-year, $2.8 million deal with OLB Quentin Groves, formerly of the Cardinals.


text:
Clarence M. "Mort" Bishop Jr., vice chairman of Pendleton Woolen Mills, died July 11 at St. Vincent's Hospital in Portland, Ore. He was 82.
This story first appeared in the July 25, 2007 issue of WWD. Subscribe Today.
The cause of death was congestive heart failure, according to a company spokeswoman.
Bishop was the fourth generation of his family to lead the Portland, Ore.-based company, which was founded in 1909. In recent years, he and his brother Broughton shared the role of vice chairman. The company has always tried to keep an even keel with the family's integrity, ethics and The Golden Rule, said the spokeswoman, adding that Mort Bishop Jr. often referred to The Golden Rule as a compass for the way Pendleton conducts business. Pendleton has deep roots in the Northwest's woolen industry. In 1863, Bishop's great-grandfather relocated to Oregon, started a small textile mill in Brownsville and was instrumental in the industry's development.
Mort Bishop Jr.'s son Clarence M. 3rd remains president of Pendleton Woolen Mills, a post he has held for the past eight years. In 1969, Mort Bishop Jr. took over the president's role from his own father and namesake.
Born in Portland, Bishop attended Phillips Academy before joining the U.S. Marine Corps. While serving with the 5th and 14th battalions, he was said to have seen "some of the worst fighting in the South Pacific" and was involved with the liberation of Guam in July 1944, a Pendleton spokeswoman said. He was among the scores of military personnel that returned to Guam to mark the 50th anniversary.
Following his honorable discharge, Bishop attended Yale University, where he graduated with a B.S. in 1949. Two years prior, he wed Mabel Alleyne Livingston, with whom he had four children. He and his late wife fished in such far-flung locales as the Seychelles, Chile, Venezuela and remote Alaskan villages. They also had a cow-calf ranching operation in southeastern Washington and a cattle and sheep farm in Newberg, Ore.
At Pendleton, Bishop learned the ropes by working at the company's various locations. When he joined the company in 1949, he worked at Pendleton's original mill in Pendleton, Ore., before moving on to its fabric mill in Washougal, Wash. Eventually, he made his way to the company's corporate headquarters in Portland. Until his death, Bishop played a hands-on role at the company, reviewing all financial and business documents and providing input, the spokeswoman said. Pendleton now employs 1,000 people.
"It's in the DNA of this family, a part of their heritage. Over the years there have been many changes and adjustments but always governed by the mantra of 'Warranted to be standard.' That goes back to C.M. Bishop Jr.'s father," she said.
He was involved in such industry groups as the American Apparel Manufacturers Association, the Men's Fashion Association and the National Association of Manufacturers.
In addition to his brother and son, Bishop is survived by three daughters, Susan, Melinda MacColl and Rebecca Martin.


text:
On Thursday night, the nation's third-ranked team, the LSU Tigers, will meet the 25th-ranked Mississippi State Bulldogs in prime time. The Tigers are pretty much a lock to win, but after Mississippi State's start to the year—averaging upwards of 320 yards on the ground and 46 points a game—the Tigers should not take the Bulldogs lightly.
In order for the inevitable victory to take place, there are several keys that need to happen for LSU's expected dominance to occur.


text:
Check out these ceiling installations from customers like you!
This modern eyewear boutique is definitely a sight for sore eyes!
This beautiful home theater looks like a lot of time and money went into it... Guess how long it took?
This garage is anything but boring with Ceilume's bold Stratford Ceiling Tiles in Merlot!
This ceiling shows a few of the many ways lighting can be incorporated into a Ceilume Ceiling!
Installing black geometric tiles adds a nice texture to the ceiling without it looking too busy.
The ceiling itself is a work of art.
Using the same style in translucent for the light fixtures, makes for a smooth, consistent ceiling design.
Our Stratford Ceiling Tiles and the track lighting add a posh feeling to this conference room.
Greenguard Gold Certification = the perfect choice for grocery stores and restaurants.
This retail store was made extraordinary with a Ceilume Ceiling Tile transformation!
Large scale applications such as this assembly room are a perfect fit for Ceilume Ceiling Tiles.
A before and after that makes a big impact!
Our Petal Ceiling Tiles gave this space all the modern flare it needed.
Southland Ceiling Panels are the perfect low budget accent for this contemporary restaurant.
Ceilume Petal Ceiling Tiles were used to create a lit canopy effect over the game room pool table.
A classy touch to a basement living room.


text:
'Spider-Man' Star Tom Holland Has a Secret Role in 'A Monster Calls'. Get the Details!
- 11:33 AM, Sep 24
65th Annual Directors Guild of America Awards - Arrivals
Photo credit: FayesVision / WENN
To fit your screen, we scale this picture smaller than its actual size. The original picture size is 646x1000 pixels and this photo has been viewed 986 times since February 02, 2013


text:
IF your saying 5 out of 5, then your saying that is was perfect, nothing wrong with it and nothing could of been better. Wrong, it could of been better and many notes were off key.
No, I won't. Your taking this the wrong way. It was GOOD, but not PERFECT.
I would rate it 3 and a half stars.
IF your saying 5 out of 5, then your saying that is was perfect, nothing wrong with it and nothing could of been better. Wrong, it could of been better and many notes were off key.
Ok I will give you an example, I won't give the link because I am not sure that is aloud. But after the video above is finished, under it will show a row of videos related to that matter. Go the the "Guitar+Flute Hyrule Song" one.
That one could be 4.5 out of 5. (He made a couple mistakes too, it's not an easy song to play).
double post.....wait no TRIPLE post
dude edit your new post or just put it in your first post before you even post it
i get what your sayin and stuff though
Oh...sorry is that not aloud?
Yeah I just didn't want you to take me the wrong way or think I was saying that he sucks..he's good.
lol in pretty much any forum its not aloudOriginally Posted by Sparx
but yea i get what your sayin
Uh oh...if a mod sees this don't punish me please...I didn't know.
sparx, dude if the timing is off its because i took a video of myself playing it and then overlayed the music AFTER. As for playing the wrong notes, the only part thats prolly wrong is the ending ones but besides that theyre fine. Last, how would i play the song with the notes in front of me? i covered that song myself...Oh and by the way if you think thats a hard song and its my best, no its not. Go to the actual page i posted the youtube video on of the zelda one and click on "more from tloztw" and look at my video titled "Dee, with chorus and reverb"
Last edited by tloztw; 02-18-2008 at 03:06 PM.
BRAWL FC:1805-1834-4411, PM me if you add me
---My covers of game music with my guitar---
-Kraid's lair (metroid)-=-=-Hyrule field (twilight princess)-=-=-
VIDS ARE ON MY PROFILE (i'll upload more when im bored)
it was cool, but i really see a problem with your technique.
for example during the last few seconds how you stopped gripping the neck and had your thumb along side your other fingers.
trust me you'll be able to play alot better if you keep your thumb in the middle in the back of neck and always have it parallel to your middle finger.
wow kid. You're certainly better than i am.
I applaud and recognize your skills, keep it up and you will certainly get better with time.
Me, well I currently suck at playing guitar. (I'm still teaching myself how to play basic chords, most of what I know is by ear.) with no formal teacher or knowledge I'm stuck trying to figure stuff out on my own (not easy when the only references I have are VG metal bands: Powerglove,Armcannon,etc.)
trying to learn from the pros is hard especially without any sort of direction.
But anyway I digress...I ramble too much.
Keep it up, you've got skills. (yes I've seen your other videos..impressive)
NiGHTS Friend code: 1633-3288-9171
Super Smash Bros. Brawl Friend code: 1633-3900-0312


text:
TAKE ACTION NOW! Join the Global Frackdown for a Ban on Fracking on September 22!
- 1502 days ago - action.foodandwaterwatch.org
Fracking threatens the air we breathe, the water we drink, the communities we love and the climate on which we depend. We need to ban fracking! Join our global day of action on September 22, 2012, to ban fracking in communities around the world.
Login to leave a comment
Or, log in with your
Facebook account:
Loading Noted By...Please Wait
butterfly credits on the news network
- credits for vetting a newly submitted story
- credits for vetting any other story
- credits for leaving a comment
Most Active Today in Environment
more Environment stories »


text: Justin and Selena have a public spat Slena and Justin Thu-13-Dec-12 16:49 Share this Tell Us What You Think WTF 0 LOL 0 FAIL 0 OMG 0 HOT 0 CUTE 0 ] Justin performed at the El Lay's Jingle ball last week and Selena Gomez was right by his side both for arrival and back stage.But it was anything but romantic. Apparently both got into an argument that ended with Gomez leaving without Justin.It is yet unknown why this argument happened but it may have been because Justin was implying he was single on stage. You May Also Like #GSCmycalvins 10 different people called the cops on Justin Bieber for doing what? 15 year old Justin Bieber singing 'Where are you Now' 7 other celebrity diva moments Become a fan of The Edge on Facebook and on Twitter .


text:
If any of you btdt moms have extreme lactose intolerance like i do, would you compare a really bad night in the loo to labor?
I dont mean a little gas here ladies. If you are truly intolerant this means, in and out of awareness, sweating , hot and cold, shaking, the worst cramps ever times 10. exhaustion, begging with God to help ect.
I think i can do nucb because i have been through this many times as well as having the kind of tooth pain that makes you throw up and that lasted for days as i had an absess over the weekend.
trying to pump myself up here, im pretty confident but curious about the lactose thing. No one gets it when i try to describe the kind of hell being severely (digestively) allergic to something can be.
thanks in advance : )


text:
- About Us
- Book Recommendations
- Signed Editions
- Kepler's Recommends
- Bestsellers
- Staff Picks
- Aggie's Picks
- Angela's Picks
- Becca's Picks
- Brittany's Picks
- Brynn's Picks
- Caitlin's Picks
- Christin's Picks
- Cressida's Picks
- Cynthia's Picks
- Jenna's Picks
- Julie's Picks
- Lane's Picks
- Lee's Picks
- Leigh's Picks
- Marilyn's Picks
- Molly's Picks
- Nancy's Picks
- Nicola's Picks
- Nicole's Picks
- Praveen's Picks
- Ron's Picks
- Sina's Picks
- Todd's Pics
- Tori's PIcks
- Award Winners
- Kepler's Events
- Community Partners
- Book Clubs
- Literary Circle Membership
The Lightning Rule (Paperback)
Usually Ships in 1-5 Days
They say lightning never strikes the same spot twice. Detective Martin Emmett is about to prove the exception to the rule. It is the summer of 1967 and a heat wave is bringing Newark, New Jersey's simmering racial tensions to a boiling point. Banished to desk duty, his career on the line, Emmett is offered a chance at professional redemption if he can quickly and quietly solve the murder of a black teenage boy whose mutilated body has been found in a subway tunnel. But Emmett discovers that the teen is a victim of a sadistic predator who abducts boys to use as prey in a twisted game of cat and mouse. While the riots engulf Newark, crippling the city with chaos, Emmett must track down the killer before the next hunt begins.
Praise For…
"Polish-American homicide cop Martin Emmett…is a terrific character." Grade: B
-Entertainment Weekly
"A gritty, historically rich narrative…Many cuts above the typical police procedural."
-Kirkus Reviews
"Evocative…a vivid portrayal of a city where racial tensions have escalated from a steady simmer to a raging boil."


text:
Job Market
If you would like to advertise a vacancy on this page please contact the Society for Cryobiology's editorial office at firstname.lastname@example.com.
Vacancy: Graduate Research Assistantship
Phase Transformations during Desiccation of Microfluidic Water Droplets
The Biothermal Sciences Laboratory at Villanova University has an immediate opening for a graduate Research Assistant. The assistantship includes complete tuition waivers as well as an annual salary of $20,500. A requirement for the position is to complete a Masters or Doctoral thesis on the research topic described below. You would be expected to devote 20-30 hours to research-related work during the school year, and to do full-time research (for pay) during the summers.
Students with a degree in Mechanical Engineering, Materials Science, Chemical Engineering, Engineering Physics, Bioengineering or related fields are invited to express their interest in this opportunity by submitting a copy of their resume or curriculum vitae (in PDF format or hardcopy only) to Prof. Jens Karlsson.
For additional information, please contact Prof. Karlsson, or visit the Biothermal Sciences Laboratory website.
Thesis Research Topic
In this NIH-funded interdisciplinary project, you will explore phase-transformation phenomena and molecular transport processes in non-equilibrium liquids. The applications for this research include materials processing (controlling microstructure during solidification), biotechnology (preservation of cells), and food technology. Experiments will focus on investigation of ice and sugar crystals in aqueous solutions, and computer models will be used to simulate novel desiccation strategies that have been proposed for long-term preservation of living cells.
You will have an opportunity to:
Vacancy: Postdoctoral Research Fellowship in tissue engineering, cell therapy and regenerative medicine.
The Program in Children's Regenerative Medicine in the Department of Pediatric Surgery at The University of Texas Medical School at Houston is seeking a Postdoctoral Research Fellow for its Cellular Therapeutics Translational Laboratory and Human Cell Processing cGMP Facility. The successful candidate will report to the Director of the facilities and must be able to work, with minimal supervision, on translational research projects related to tissue engineering, cell therapy and regenerative medicine. Among primary responsibilities, the incumbent will be responsible for the development of improved vitrification solutions and conditions for cells and/or tissues and transitioning innovative tissue engineering therapeutic approaches from experimental pre-clinical models to clinical applications. After proper training, additional responsibilities will include participating in the production of clinical grade, cell and tissue engineered products. The ideal candidate will have a Ph.D. or equivalent degree in a relevant scientific discipline, research experience in cryobiology and vitrification technology, a keen interest in stem cells, tissue engineering and regenerative medicine, and experience with pre-clinical studies using animal models as well as with aseptic methods of harvesting, purification, processing, culture, storage and characterization of human stem cells. He/she will be strongly motivated to work both independently and as a team member in a highly interactive and dynamic research environment, with a proven ability to conduct and publish research and an enthusiasm to learn and develop new techniques. This position will work closely with physicians, scientists, experts in regulatory issues and process development, and other postdoctoral fellows within the Program of Regenerative Medicine.
The Program has over 5,000 square feet of state of the art, fully-equipped basic laboratory and tissue engineering facilities as well as over 2,500 square feet of cGMP laboratories for production of clinical grade, cell and tissue engineered products. This initiative will help to save children's lives and improve the quality of their lives by developing techniques and therapies to repair damaged organs or birth defects in children.
To apply, please provide a cover letter with a brief description of your research background and interests, and a Curriculum Vitae with the contact information for 3 professional references to Dr. Fabio Triolo (firstname.lastname@example.com) with a CC to Stephanie Baca (firstname.lastname@example.com).
UTHealth is and EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, genetics, disability, age, or any other basis prohibited by law. EOE/M/D/F/V.
Vacancy: Postdoctoral position is available in a project on cryopreservation of ovarian tissues and improvement of cryopreservation by antifreeze proteins
Vacancy: Plant Research Post-doctoral Fellowship
The candidate will work to recover in vitro tissues from cryostorage, evaluate growth, regenerate culture lines, and re-bank samples. A major focus will be on analyzing the data from this large study in relation to species, genotype, age, original viability, sample preparation, number of replicates, and storage location, and to examine the relationship of these factors to survival. Other duties will include working with Horticulture and Education staff to provide plants from this project and background information for display. Further duties will involve working with other members of the project team, managing staff, preparing scientific papers, reports, and presentations.
For further information please download the job specification.
Vacancy: Postdoctoral fellowship in the area of cryobiology and regenerative medicine
Location: Medical College of Georgia/Augusta University, Augusta, GA, USA
Closing Date: Until filled
A post-doctoral position is available at the Department of Neuroscience and Regenerative Medicine / Medical College of Georgia to study preservation of stem cells and oocytes. Familiarity with stem cells and oocyte/embryo-related techniques is preferred. Interested applicants should submit a CV and contact information of three references to Dr. Ali Eroglu at firstname.lastname@example.com.
Vacancy: Culture Media Scientist
Department: Engineering
Primary Function:
To oversee and organize all aspects and duties, in a professional manner, that relate to the research and development of Assisted Reproduction Culture Media products and processes.
Essential Job Functions/Duties (may include other duties as assigned)
• The design, development, manufacture, testing and validation of new media formulations used in Cook Medical's Assisted Reproductive Technology product range.
• Writing of project documentation including, but not limited to: Test methods, test reports and validation protocols
• Work in a state that is suitable for the manufacturing of aseptically filled products in an ISO Class 7 Clean Room and ensure all tasks are performed in a manner that is suitable for a clean room environment
• Ensure all procedures are performed to a standard that adheres to Good Manufacturing Practices
• Ensure all new prototype and pilot products are manufactured in accordance to Good Manufacturing Practices
• Self-motivated with the ability to work with minimal supervision with initiative and drive for timely completion of project goals.
• Prepare and maintain accurate documentation consistent with the requirements of pertinent regulations and Cook's Quality Management System where applicable
• Good verbal and written communication skills, effective before groups and in project documentation.
• Make decisions relating to Media R&D projects in consultation with Global Product Manager, Engineering Management, SBU and other relevant departments
• Communicate effectively with Media manufacturing where new formulations, the manufacture of pilot batches or product transfers are required
• Communicate effectively with Regulatory Affairs staff to ensure that all regulatory requirements are met for new Media products
• Document research and development process through lab notebooks or other accepted methods
• The ability to successfully lead cross functional teams in a Project Leader role (previous project management experience preferred).
• Strong project management skills.
For work/educational requirements please visit https://www5.recruitingcenter.net/Clients/cookmedical/PublicJobs/controller.cfm?jbaction=JobProfile&Job_Id=13965&esid=az


text:
Store Hours
We'd love to hear from you.
We are available to take your call or during store hours.
Saturday 9am to 9pm
Store Locations & Hours
Shop Living ▸
Shop Mattresses ▸
Shop Free Ship ▸
Beginnings 3PK Table Set
The Beginnings 3 Pack Table Set includes a cocktail table and two end tables that are finished on all sides for versatile placement.
Dimensions:Height - 17.12" Width - 35.25" Depth - 19.5"
Compare at $139.99


text:
1 (800) 889-8967
Live Chat
Track My Order
Free Shipping over $85*
Auto Ship and Save 10%
My Account
Sign in
Top Dog Categories
Dog Toys
Dog Treats & Chews
Dog Food
Pillow, Bolsters & Lounger Beds
Collars, Leashes & Harnesses
Flea & Tick Supplies
Joint Supplements
Dog Training Supplies
Kidney, Liver & Renal Health
Skin & Coat
See more
Top Dog Brands
Joint MAX Triple Strength
Glyco Flex III
CET Chews
K9 Advantix II
Simply Wild Dog Food
Bonies Treats
See more
Top Cat Categories
Cat Toys
Cat Food
Cat Treats and Chews
Flea and Tick Supplies
Lysine Products
Litter and Litter boxes
Cat beds
Ear and Eye Cleansers
Joint Supplements
Cat Scratcher Toys
See more
Top Cat Brands
CET Toothpaste
Cosequin for Cats
Advantage II
Enisyl F
CET chews for Cats
Zymox Otic
See more
Other Pets
Small Pets
See more
Top sellers
Advantage II
K9 Advantix II
Joint Max
CET Chews
Frontline Plus
Kong Toys
See more
Halloween Store
Pet Boutique
Red Tag Sales
Autoship & Save
Pet Tech
Daily Deal
See more
Flea & Tick Supplies
Oral Treatments & Supplements
Shampoos & Dips
Sprays, Wipes & Powders
Herbal & Natural Remedies
Flea Combs & Tick Removers
Home & Yard Treatments
Insect Repellents
View All
Joint Supplements
Hip & Joint Maintenance
Extra Strength Joint Support
Senior Joint Supplements
View All
Dental Products
Dental Water Additives
Other Dental Products
Dental Supplements
Toothbrushes & Toothpastes
Dental Cleansing Gels & Foams
Dental Sprays & Rinses
Dental Wipes
View All
Skin & Coat
Fish Oil & Omega Supplements
Skin & Coat Nutritional Supplements
Skin & Coat Topicals
Anti-Itch & Hot Spot Solutions
Anti-Shedding Solutions
View All
Health & Wellness
Allergy Aids
Pain Medications
Test Kits for Pets
First Aid & Remedies
Medication Administration
E Collars
View All
Kidney, Liver & Renal
Liver Support Supplements
Kidney & Renal Support Supplements
Urinary Tract & Bladder Support
View All
Ear & Eye Products
Ear Mite Control
Eye Cleansers & Treatments
Ear & Eye - Wipes & Pads
Eye Lubricants
Tear Stain Products
Ear Cleansers & Treatments
View All
Food Supplements
Laxatives & Hairball
Stool Eating Preventatives
Pet Weight Loss
Nutritional Supplements
Antioxidants, Immune & Cognitive Support
Probiotics & Digestion Supplements
Urine Odor & Lawn Burn Supplements
Performance & High Calorie
Lysine Products
View All
Pet Food & Treats
Dog Food
Dog Treats & Chews
Cat Food
Cat Treats & Chews
View All
Pet Toys
Dog Toys
Puppy Toys
Cat Toys
View All
Training & Behavior
Bark Control
Training Collars
Cat Anxiety & Stress Solutions
Dog Training Accessories
Taste Deterrents
Wild Animal & Rodent Control
Pet & Animal Deterrents
Potty Training Accessories
Dog Anxiety & Stress Solutions
Remote Training Systems
View All
Pet Supplies
Cleaning & Sanitation
Feeding Supplies
Grooming Supplies
Pet Home & Travel Essentials
Pet Tech & Gadgets
View All
Products for Pet Lovers
Animal Lovers
Cat Lovers
Dog Lovers
View All
More ways to save
Find us on
Entirely Pet Care 101
Pet Diseases
What are roundworms?
are live intestinal worms that live in the intestines and deprive their hosts of nutrients. On average they are about 3-5 inches. Roundworms, sometimes called ascarids, pass moderate numbers of microscopic eggs which are found in the pet's stool. Like hookworm eggs, they must be found with a microscope. They do not attach to the wall of the intestine, as do some worms. Instead, they are literally swim within the intestine.
If left, roundworms will continue to grow and multiply and may block the intestinal track completely.
If left untreated they can pose a serious risks for young dogs/cats and puppies/kittens.
They can be an important cause of illness, and even death, in kittens.
How are Roundworms are transmitted?
Puppies/Kittens born to mothers that have had roundworms at any time in the past can transmit them to their litter before birth.
More than 90% of puppies are born with roundworms or acquire them shortly after birth from their mother. Both litter and adult mothers may become infected by swallowing roundworm eggs which contain
infective larvae. The larvae hatch out in the dog's stomach and small intestine and migrate through the muscle, liver, and lungs. After several weeks, the larvae make their way back to the intestine to mature. When these worms begin to reproduce, new eggs will pass in the pet's stool, and the life cycle of the parasite is completed.
Roundworm eggs are resilent and can survive in areas such as parks, playgrounds and yards. Obviously, roundworm eggs passed in one pet's stool may be infectious to other animals. Interestingly, a large number of other animal species have been found to harbor roundworms and represent potential sources of infection for dogs. These include cockroaches, earthworms, chickens, and rodents.
Signs of Roundworm Infection
Respiratory distress
Loss of appetite
Weight Loss
Dull, scruffy fur
Swollen abdomen ("pot belly")
How are Roundworms treated?
Treatment is quite simple. Several very safe and effective drugs are available to kill roundworms in the intestine. Some of these drugs temporarily anesthetize the worms so that they pass out of the dog with a normal bowel movement. The live or dead worms are found in the stool. Because of their large size, they are easily seen.
Dewormers help remove parasites from your pet. It is important to give regular dewormer treatments to your dog and cats. It is recommended at least once every six months. We carry a great variety of effective deworming medications at low prices. We offer pet deworming products for Roundworms, Hookworms, Whipworms & Tapeworms. Buy worm treatment medicine and remove the worms in your pet with prescription and non-prescription pet medications.
Shop for deworming products here
Recommended Dewormers
Pyrantel Pamoate Wormer by Qualitest
Nemex-2 (16 fl oz)
Nemex-2 Wormer by Pfizer: 2 oz (60 mL)
Worm Protector 2X Double Strength
Are Roundworms a danger to me or my family?
Roundworms can be a health risk for humans. The most common source of human infection is by ingesting eggs that have come from soil contaminated with cat (or dog) feces. As many as 10,000 cases of roundworm infection in humans have been reported in one year in the United States. Children, in particular, are at risk for health problems should they become infected. A variety of organs may be affected as the larvae migrate through the body. In suitable environments, the eggs may remain infective to humans and pets for years.
What can be done to control Roundworm infection in dogs and to prevent human infection?
Pregnant queens should be dewormed in late pregnancy to reduce potential contamination of the environment for newborn litters.
All new litters should be treated by 2-3 weeks of age. To effectively break the roundworm life cycle, litters should be dewormed on the schedule recommended by your veterinarian.
Prompt deworming should be given when any parasites are detected; periodic deworming may be appropriate for pets at high risk for reinfection. Adult dogs and cats remain susceptible to reinfection with roundworms throughout their lives.
Pets with predatory habits should have a fecal examination several times a year. Rodent control is desirable since rodents may serve as a source of roundworm infection for dogs.
Prompt disposal of all pet feces is important, especially in yards, playgrounds, and public parks.
Strict hygiene is especially important for children. Do not allow children to play in potentially contaminated environments.
Customer Service
About Us
Help Center
Live Chat
Contact Us
Pet Articles & Resources
EntirelyPets Blog
New Pet Products
Pet Care 101
Video Gallery
Toxic Foods & Plants for Dogs
Top 12 Most Loyal Dog Breeds
Best Joint Supplements for Dogs
Connect With Us!
Don't miss new products, coupons, and deals!
My Account
Track My Order
Shopping Cart
Rewards Program
Shop By Brand
Mobile Site
© 1999-2016 EntirelyPets. All Rights Reserved
~ My Account Login ~
Sign into your
EntirelyPets Account
for the best experience!
No account? Sign up and Earn Rewards