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Posts Tagged 'environment'
Distant Hammers
February 4, 2016 | by Ben Mauk
Notes on art and apocalypse.
How will the end come? Did it already come? Did we miss it? That we can ask this last question shows just how far our current mood of millenarianism has traveled from its antecedents in the distant and not-so-distant past. As late as Eliot, poets and prognosticators assured us that we would recognize "how the world ends." Most visions of apocalypse were spectacular, sublime. The possibility that we have instead whimpered our way into some kind of boiling-frog scenario—marked by slow but irreversible global warming, mass human displacement, and a gradually perceptible slide toward famine, disease, war, and extinction—is a radical departure from the convulsive display we'd long been promised.
The first properly apocalyptic writings in the monotheistic tradition are the books of Joel and Zechariah, two of the twelve minor prophets in the Tanakh, or Jewish canon. Joel, whose account may date to the reign of King Josiah, around 800 B.C., and who may therefore be the oldest prophet, begins by describing a coming locust infestation, which he claims will be coincident with famine and widespread misery. The lament transforms into a hallucinogenic description of locusts as God's army ("the increasing locust, the nibbling locust, the finishing locust, and the shearing locust"), of a fire that consumes the world, and of a day of thick darkness "like the dawn spread over the mountains." The more famous book of Daniel follows approximately in this mold, albeit with new messianic trappings. Read More »
Letter from COP21
December 11, 2015 | by Porter Fox
Day 0
There are more police than protestors at Place de République. White vans block the ten streets leading into the square. Officers wearing black shoulder pads, batons, tear gas canisters, machine guns, pistols, pepper spray, walkie talkies, cell phones, earpieces, sound grenades, assault rifles, plastic shields and handcuffs casually chat as the protest grows. On a side street I watch a policeman pass a large Tupperware container filled with salad around to his fellow officers.
The planet has warmed rapidly since the late nineteenth century, and nearly two hundred countries have come to Paris to talk about it. Protestors from half as many nations came, too, and planned the largest climate march in history. It was supposed to start in Place de République this morning. Since the Paris attacks of November 13, the government of France declared a state of emergency and banned the march, along with most other large public gatherings. Read More »
Essex Girl
February 21, 2013 | by Zakia Uddin
We traveled from East London in a Zipcar, beating the traffic bound for Lakeside, the out-of-town shopping center. The pier car park was sparsely filled with cars. Abandoned in a corner was a statue of the Virgin Mary the size of an umbrella stand. Out of season, the Essex archipelago lures only the most hardened. By October, the weather is spitting and icy, and its landscape is too bleak and monotonous to qualify as ruggedly beautiful. A Wikipedia entry had told us there are nineteen islands off the coast of Essex, most of them owned by the British Ministry of Defence and contracted to private companies testing ammunitions. The individual entries were nearly all stubs, waiting to be filled in. An archipelago struck a curious exotic note in a place associated mostly with commuting, military test sites, and, most recently, "constructed reality" television.
American import Jersey Shore inspired The Only Way is Essex, a show similarly centered on the intricate love lives of pneumatic people living in an area derided for being culturally bankrupt, despite its proximity to one of the most exciting cities in the world. Jersey's Essex County was even named after the UK's own historical Essex, in 1683. Maybe there's no need to make analogies between the UK's Essex and anywhere else because its reputation is internationally bad, and we don't defend it. The county town Chelmsford, where I was born, was voted eighth best place to live in the UK on the prerecession property-porn show Location Location Location. Residents promptly rang in to call it soulless; flashy on one hand and tedious on the other, like a nouveau riche neighbor with dull preoccupations. Read More »
Watching the Oil Spill
June 14, 2010 | by John Jeremiah Sullivan
Dear Lorin,
It's strange that, right as you confer on me the undeserved (but I hope not wasted) honor of Southern Editorship, this region would reclaim its hold on the American imagination. I refer to the underwater live feed of the oil leak. Are you watching it? Down here we do little else. I made these notes on the experience. They may not be appropriate for the new blog. You said on the phone, if I remember, that you wanted to cover "the intersection of culture and everyday life." But the leak has simply overpowered culture, to the extent that anything happening in that department now assumes a ghoulish cast.You can feel the other millions of people watching, especially late at night, and at times there has even been a Lincoln's Death Train quality to this thing, a sense of shared, and deliberately prolonged, mass shock.
On YouTube, collections have formed of people's favorite moments from the feed, sequences they found beautiful, or ones that appear to support a theory they developed about something BP did and lied about.
When something odd occurs in the frame—when three orange sponge-looking objects float by, for example, or when a striped tube-shaped thing rises up at the left and vanishes into the oil—there's this reflex to call out to the others, and verify that they've seen it.
One clip going around shows an eel that swims up to the plume and hangs out for a few seconds, like, What the . . .
It looks as if they've somehow beamed a Victorian-era smokestack to the bottom of the ocean, and it's billowing brown ash.Read More »


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Added by WINNER GUARANTEED on 2 June 2012
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Prize: Grand Prize is a A Meridian GrainMax 4000 bin with foundation, viewglasses (2), levalert, manway, roof vents (2), and a GG 7000 6' aeration rocket. Delivery of the prize is included. ARV $24,655.
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subset: commoncrawl


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While the National Hockey League remains in a lockout (which is now in its 47th day) perhaps we should look back at a happier time surrounding the sport and league which came to be not only a national passion, but the content for the longest running Canadian television show in history.
Lets face it. What would hockey be for Canadians without Hockey Night In Canada? In what would be its 60th season, HNIC has changed the sports broadcast scene and evolved with the game since its debut on radio in 1931. It was 60 years ago today (Nov. 1) that CBC TV aired the first English broadcast, but perhaps what you might not know is that the very first televised NHL game was actually broadcast on the french equivalent to HNIC; La Soirée du hockey. Check out this story about that historical moment in Canadian television history as the Montréal Canadiens took on the Detroit Red Wings on October 11, 1952:
Don't forget to catch HNIC's Ron MacLean and Don Cherry on tonight's (Nov. 1) episode of George Stroumboulopoulos Tonight at 7pm.
Hockey Night Stars Share Top Moments
What Can Ron and Don do During the Lockout?


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Funky Ring - Paparazzi
The Funky Ring is a heavy statement ring in sterling silver. The collection comes with three different engravings.
Sans Peur - Without Fear
Amor Fati - The Love For Our Destiny
30 x 10 mm.
*The Funky Ring Collection is only available in Efva Attling concept stores and online.
Efvas thought A powerful ring with three different messages to find their owner.
Shop Online
Price $470 $470


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Apple is reportedly in talks to buy car maker McLaren
Technology giant Apple is reportedly in talks to buy British car company McLaren.
Technology giant Apple is reportedly in talks to buy British car company McLaren.
UpdatedA selection of superb mobile games that make Google-powered phones and tablets come alive.
Microsoft has removed all the gubbins that pushed its new OS on Windows 7/8.1 PCs.
Thankfully, the hackers have been working alongside Tesla.
This tasty-looking offering from the Asus ROG stable is built around Nvidia's GTX 1060.
The HyperAdapt trainers bring to life the Back to the Future dream.
UpdatedSo you've got an iPad and now you have no cash left to buy any games. Have no fear, because there are plenty you can get for no money at all.
Deathadders and BlackWidows everywhere are suffering compatibility woes.
OpinionOculus Rift began life as the poster child for the virtual reality revolution, but its latest pricing leak is giving the competition an edge.


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Important Global Message
The Miami-Dade County Emergency Operations Center has been activated and is closely monitoring Erika. For any updates about County facilities and services, please visit: http://www.miamidade.gov/emergency
Inside District 9
District 9 Map
Find your the District 9 Commission Office, the District 9 boundaries and more on the District 9 Map.
Small Business Grant Program - Mom and Pop Grants
The Mom and Pop Small Business Grant Program was created to provide financial and technical assistance to qualified small businesses that are approved for funding.
The Moss Plan
In recognition of the overwhelming needs that existed in some of South Dade's long-neglected communities prior to, and in the aftermath of Hurricane Andrew, Commissioner Moss sponsored the "South Dade Neighborhood Development Concept Plans", which was renamed by a unanimous vote by the Commission, "The Moss Plan".
Citizen's Forum
The forum is an open invitation for residents of District 9 to voice their concerns to the Commissioner.
Libraries Near You
Locate a library near you.
County Parks Near You
Locate a park near you.Back to Top Page Last Edited: Thu Aug 11, 2016 2:14:01 PM
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Snag discounted fares on the 'Best Domestic Airline' for the ninth year in a row (Travel + Leisure World's Best Awards)
Grab a seat for summer and jet across the country on the 'Best Domestic Airline.'
Get a taste of all Seattle has to offer and save 45% on admission to the city's top attractions.
Unwind at Penelope and The Beauty Bar in the AAA 4-Diamond Fairmont Olympic, named one of Seattle magazine's "favorite pampering spots."
Save up to 60% on your choice of multi-show packages, including the new, visual-effects-packed production of Disney's "The Little Mermaid."
Paca Pride is "a relaxing stay away from the bustle of the campground crowds," praised for supreme hospitality and cozy quarters (Seattle Backpackers Mag).
Take advantage of warm summer days and explore Puget Sound with a paddleboard rental for half off any day of the week through November.
Leavenworth's Oktoberfest "will make you feel like you stepped right into Bavaria" (Forbes Travel Guide). Save more than $55 on an all-inclusive trip.
Electric bikes make riding easy; start at the waterfront and ride through the city to the famous West Point Lighthouse with 60% off tours.
Save up to 40% to any performance of "Dangerous Liaisons" at ACT Seattle, called a "terrific play" by Huffington Post.
Embark on a full-day trip to this charming Bavarian town for its annual Christmas lighting festival, complete with carolers, Christmas performances and more.
Save on flights to Seattle for travel into December
Get more space with an intermediate SUV and save up to 35% on competing rates
Save up to 55% on tickets to this LA Times "top pick"
Hotels with Member-Exclusive Extras
Set on the pier, it's the "only true waterfront hotel" in Seattle, according to Frommer'sAvailable year-round
Please go to your email and confirm your subscription.


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Created using this Craftsy indie pattern
This project was made from an independent Craftsy designer's pattern:
My Valentine Quilt Pattern »
by FrivolousNecessity
Other projects made as part of this pattern:
QuiltingValentine wall hanging
QuiltingHearts of Plenty
QuiltingBe My Valentine
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
that is a nice quilt .
01/11/2014 Flag
I love this pattern, but was wondering if the quilt could be made bigger? I am a pattern user and wonder if I purchase this pattern that I wont be able to make it bigger...
06/09/2015 Flag
Well, you could print out the heart section larger and adjust sizes of border squares and other fabric amounts accordingly. However, you'd have to be quite confident and knowledgeable in the process. I would suggest contacting the designer herself for best advice.
02/05/2016 Flag


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If former National Football League players can get millions from the NFL for old head injuries, could former musicians be compensated for secondhand tobacco smoke-related injuries or illnesses from performing in bars?
Tobacco is a product that when used as designed will harm the user and all those around. We stopped the use of; leaded gas, asbestos, red dye #2, DDT and open sewers in the street and so on, all because of the harm done by them. Tobacco is no different.
I speak fluent sarcasm - that's the way I read it.
No brainer.
Is an avitar anything like an avatar?
I can't learn if I don't ask questions."
This may be the first thumbs up I have ever gotten!
So you and HA could not find anything to debate about in today's debateless newspaper?


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Rating: 4.6 out of 14 votes
Restraint (2008)
Movies Drama Thriller
19 August 2008 (USA) IMDB 6.2 Travis Fimmel, Teresa Palmer, Stephen Moyer, Philip Holder, Margie McCrae, Peter Davies, Taylor Owyns, Keith Robinson, Nate Jones, Alyssa McClelland, Patrick Ward, Joanne Hunt, Michael Willesee, Vanessa Redgrave, Fabio Nardo
Director: David Denneen | Country: Australia | Language: English Mpaa: Rated R for violence, sexual content and language
The Plot
A small time criminal, Ron, has killed the boss of his girlfriend and they are escaping from the police. After killing a gas station attendant, Ron drives to an old manor in the middle of nowhere where Andrew, an agoraphobic, lives, in order to exchange their car. When he notes that Andrew is a wealthy man, Ron decides to get money from Andrew to travel to Thailand. Andrew notices that Dale resembles his fiancée, Gabrielle, who left him six months ago. He proposes that Dale dye her hair and go to the bank with two cheques of $20,000.00 pretending that she is Gabrielle. But things do not go according to plan.
There are 16 links for Movie - Restraint (2008)


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Tyra's Making the Most of New Top Model Judge Rob Evans Already
Yes, that means she's got him in a photo shoot, nearly naked. Well played, Ms. Banks.By Alex Rees
Yes, that means she's got him in a photo shoot, nearly naked. Well played, Ms. Banks.By Alex Rees
He's been stringing us along, that sneaky fellow.By Charlotte Cowles
And has more nasty things to say about Tyra, too.By Charlotte Cowles
The 19th cycle will be college-themed.By Hilary Moss
The flawsome part just had to get squeezed in somewhere!By Charlotte Cowles
Plus, Tyra Banks wore too much eye makeup.
Plus Tyra went to Disneyland! With Drake.
"He's a Harvard alum!"By Jada Yuan and Jennifer Vineyard
But they're all "a family," so the fun will never "end"!By Hilary Moss
And Bryanboy might be waiting in the wings.By Hilary Moss
They're apparently like training bras.By Alex Rees
The results are worse than you could ever possibly imagine.By Alex Rees
They don't know what they missed out on.By Alex Rees
Yep, blame Canada.By Alex Rees
She plays a frumpy librarian.By Alex Rees
You'd think they were ASKED to be mean or something, gosh.By Alex Rees
And rightfully so.By Alex Rees
Models eat, don't enjoy it at all.By Alex Rees
A court awarded Ananda Marchildon the money she'd asked for.By Alex Rees
Plus, Rihanna's emergency hair appointment.


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Forget what you know about promotional videos, because the BYU Cougars just set the standard.
What you are about to watch is a promo for BYU's upcoming basketball home game against Prairie View A&M on Dec. 11, and it is spectacular.
Just make sure none of your friends are around when you hit "play."
Yes, that's BYU stars Tyler Haws and Eric Mika, flanked by Skyler Halford and Luke Worthington, lip-syncing the 98 Degrees song "Because Of You."
The Cougars have been doing this for all their home games this season, sampling some of the best hits in recent pop history.
A tip to all you colelgiate sports marketing departments out there: You're doing it wrong.


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Dirty Second Hands
|"Dirty Second Hands"
|Single by Switchfoot
|from the album Oh! Gravity.
|September 26, 2006
|Alternative rock
|3 min 16 s
|Columbia/Sony BMG
|Jon Foreman
Todd Cooper
|John Fields
"Dirty Second Hands" is a song from Switchfoot's 6th studio album Oh! Gravity. This was the first song released from the album, made available for purchase online as a single. Despite this, the song was never released to radio.
When the band first posted the song for streaming on their web site, it contained several differences from the album version. The first verse was backed by an electric guitar section which on the album version does not appear until the second verse. The chorus also did not have the brief electric guitar dropout between vocal lines. Unlike the album version, this version was significantly shorter because it did not contain the vocal portion of the bridge. A few days later this version of the song was replaced by the final album version.
"Dirty Second Hands" was produced & recorded at Bigfish Studio by John Fields. As per executive producer Steve Lillywhite's suggestion, the earliest rough mix from the day the song was tracked was used on the album.
This song was introduced into the band's live show during the Fall 2006 leg of the Oh! Gravity. Tour prior to the album's release and quickly became a concert favorite. The concert version of the song features an extended instrumental coda which includes frontman Jon Foreman wildly beating a suspended cymbal and climaxes in a distorted guitar solo by Drew Shirley. The light show for this guitar solo during the Appetite for Construction Tour incorporated large amounts of unsynchronized strobe lights, increasing the dramatic effect. The coda closes with an instrumental reprise of the chorus riff, at the end of which the band suddenly cuts off.
The song uses unusual time signatures, the intro being in 5/4 with the last bar in 3/4. The chorus is first in 3/4 for three bars and then a bar of 2/4 followed by two bars of 5/4, while the verse is in 5/4. The breakdown is in 4/4 on the drums.
Other appearances[edit]
The song also appears as a track from Dave Matthews Band's tour sampler, So Much to Save.[1] An early version is also found on their late 2010 EP Eastern Hymns for Western Shores.
- ^ Switchfoot's "Dirty Second Hands" featured on Dave Matthews compilation album - Published August 18, 2009 (retrieved August 18, 2009)
External links[edit]
|This 2000s rock single–related article is a stub. You can help Wikipedia by expanding it.


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Viewing Tattoo Tag: disney
Alice In Wonderland08/06/15
Disney sleeve.
I got the disney sleeve because for years since i was young my family took me to disneyworld in Orlando . It was my grans favourite place . She sadly passed away from lung cancer . The tattoo is in… [ read more ]07/27/15
Disney Good and Bad
I am a huge Disney fan and always have been since I can remember, these tattoos dont have a particular meaning but I just like knowing they are there and that a part of me will never grow up. I… [ read more ]07/27/15
Disney's Fantasia
For years, I have been a huge Disney fan and I thought that having scenes from Fantasia would be a great homage to Disney and Mickey Mouse. The tattoo was done at Renaissance Tattoo in Woonsocket by Doug06/15/15
Disney tattoo
It's a tattoo I did to remember my childhood, had a difficult one but seemed good when I watched a disney movie.05/05/15
Day of the Dead Snow White04/17/15
Hidden Mickey
what can i say im obsessed with Disney04/10/15


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Arsenal 3-0 Chelsea - Antonio Conte Full Post Match Press Conference
- published: 24 Sep 2016
- views: 58
Post match press conference with Chelsea manager Antonio Conte following their 3-0 loss to Arsenal in the Premier League. Please like the video and share wherever you can! To make sure you don\'t miss any of my videos on this and my other channels please : Subscribe to this channel : http://bit.ly/BeanymanSportsSub Follow me on Twitter : http://www.twitter.com/BeanymanSports Check out my website : http://www.BeanymanSports.com Like me on Facebook : https://www.facebook.com/BeanymanSports Follow me on Google+ : https://plus.google.com/+BeanymanSports Thanks...


text: Col d'Orcia Rosso di Montalcino 750ML 2009 Sku: 9773 Located in southern Montalcino in the area of Sant Angelo in Colle. The vines enjoy a favorable southern exposure granting the vineyards with the blessing of the sun rays the whole day long. Average height is about 1000 ft above sea level. Tasting notes Color - Deep ruby red with purple reflections Bouquet - Fresh, intense aromas of ripe fruit infused with spice from the oak Taste - Full-bodied and fruit forward, structured by supple tannins Wine maker notes Grapes ferment on the skins for twelve days at a controlled temperature of less than 82ºF (28ºC) in shallow, wide steel tanks (150 hl), in order to obtain a delicate tannin and color extraction. Technical notes 100% Sangiovese. Food pairing Serve slightly cooler than room temperature. Well-matched with veal, pork and poultry dishes, as well as duck and goose. Related SearchesItalyTuscanyRosso di MontalcinoBolgheriBrunello di MontalcinoCarmignano Regional Wineries:ArgianoCastello Banfile Presi Country: Italy Region: Tuscany Sub-Region: Rosso di Montalcino Grape Varietal: Sangiovese Type: Still wine Reg. $22.99


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Most Cited Current Opinion in Pharmacology Articles
The most cited articles published since 2011, extracted from Scopus.
The role of serotonin receptors in the action of atypical antipsychotic drugsH. Y. Meltzer | B. W. Massey
Volume 11, Issue 1, February 2011, Pages 59-67
The main class of atypical antipsychotic drugs (APDs) in current use includes the protypical atypical APD, clozapine, as well as aripiprazole, asenapine, iloperidone, lurasidone, olanzapine, quetiapine, risperidone, and ziprasidone. At clinically effective doses, these agents produce extensive blockade of serotonin (5-HT)2A receptors, direct or indirect stimulation of 5-HT1A receptors, and to a lesser extent, reduction in dopamine (DA) D2 receptor-mediated neurotransmission. This contrasts with typical APDs, for example haloperidol and perphenazine, which are mainly DA D2/D3 receptor antagonists and have weaker, if any, potency as 5-HT2A receptor antagonists. Some, but not all, atypical APDs are also effective 5-HT2C receptor inverse agonists or neutral antagonists, 5-HT6 or 5-HT7 receptor antagonists. This diverse action on 5-HT receptors may contribute to significant differences in efficacy and tolerability among the atypical APDs. There is considerable preclinical and some clinical evidence that effects on 5-HT receptors contribute to the low risk of producing extrapyramidal side effects, which is the defining characteristic of an atypical APD, the lack of elevation in plasma prolactin levels (with risperidone and 9-hydroxyrisperidone being exceptions), antipsychotic action, and ability to improve some domains of cognition in patients with schizophrenia. The serotonergic actions of the atypical APDs, especially 5-HT2A receptor antagonism, are particularly important to the differential effects of typical and atypical APDs to overcome the effects of acute or subchronic administration of N-methyl-d-aspartate (NMDA) receptor antagonists, such as phencyclidine, ketamine, and dizocipline (MK-801). 5-HT1A receptor stimulation and 5-HT6 and 5-HT7 receptor antagonism may contribute to beneficial effects of these agents on cognition. In particular, 5-HT7 receptor antagonism may be the basis for the pro-cognitive effects of the atypical APD, amisulpride, a D 2/D3 receptor antagonist, which has no effect on other 5-HT receptor. 5-HT2C receptor antagonism appears to contribute to the weight gain produced by some atypical APDs and may also affect cognition and psychosis via its influence on cortical and limbic dopaminergic activity. © 2011 Elsevier Ltd. All rights reserved.
Monoclonal antibody therapeutics: History and futureNicholas A P S Buss | Simon J. Henderson | Mary McFarlane | Jacintha M. Shenton | Lolke De Haan
Volume 12, Issue 5, October 2012, Pages 615-622
Over the last three decades, monoclonal antibodies have made a dramatic transformation from scientific tools to powerful human therapeutics. At present, approximately 30 therapeutic monoclonal antibodies are marketed in the United States and Europe in a variety of indications, with sales in the US alone reaching approximately $18.5 billion in 2010. This review describes how antibody engineering has revolutionized drug discovery and what are considered the key areas for future development in the monoclonal antibody therapy field. © 2012 Elsevier Ltd.
Selective PDE inhibitors as novel treatments for respiratory diseasesClive P. Page | Domenico Spina
Volume 12, Issue 3, June 2012, Pages 275-286
Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell types and in the context of respiratory diseases, It is now recognised that the use of PDE3, PDE4 and mixed PDE3/4 inhibitors can provide clinical benefit to patients with asthma or chronic obstructive pulmonary disease (COPD). The orally active PDE4 inhibitor Roflumilast-n-oxide has been approved for treatment of severe exacerbations of COPD as add-on therapy to standard drugs. This review discusses the involvement of PDEs in airway diseases and various strategies that are currently being pursued to improve efficacy and reduce side-effects of PDE4 inhibitors, including delivery via the inhaled route, mixed PDE inhibitors and/or antisense biologicals targeted towards PDE4. © 2012 Elsevier Ltd. All rights reserved.
Chemokines and cytokines in neuroinflammation leading to neuropathic painNorikazu Kiguchi | Yuka Kobayashi | Shiroh Kishioka
Volume 12, Issue 1, February 2012, Pages 55-61
There has been recent evidence showing the correlation between neuroinflammation owing to the chemokine-cytokine network and neuropathic pain. Chemokines and cytokines are derived from several types of cells in the peripheral and central nervous systems following nerve injury, and are largely involved in the pathogenesis of neuropathic pain. The roles of typical inflammatory cytokines such as interleukin-1β have become the recent center of attention. There is growing evidence that inflammatory chemokines (CCL2, CCL3, and fractalkine) play pivotal roles in neuropathic pain. Further investigations concerning the functions of the chemokine-cytokine network-mediated regulation of neuroinflammation may lead to novel therapeutic strategies against intractable neuropathic pain. © 2011 Elsevier Ltd. All rights reserved.
Resolution phase lipid mediators of inflammation: Agonists of resolutionCharles N. Serhan | Nan Chiang
Volume 13, Issue 4, June 2013, Pages 632-640
Lipid mediators are appreciated for their roles in leukocyte traffic required in host defense. With identification of novel resolution phase mediators, resolvins, protectins and maresins, these three families and their aspirin-triggered forms, given their potent stereoselective actions with human cells and animal disease models, are coined specialized pro-resolving mediators (SPM). Stereochemistries of key SPM are established and several groups reported organic synthesis. Given increased availability, this two-year-review period expands their potent pro-resolving and non-redundant actions. Collectively, they support the concept that return of acute inflammation involves active biosynthesis and SPM signaling toward homeostasis. © 2013 Elsevier Ltd. All rights reserved.
Intrarenal angiotensin II and its contribution to the genesis of chronic hypertensionL. Gabriel Navar | Minolfa C. Prieto | Ryousuke Satou | Hiroyuki Kobori
Volume 11, Issue 2, April 2011, Pages 180-186
The increased activity of intrarenal renin-angiotensin system (RAS) in a setting of elevated arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation, fibrosis and renal injury. Increases in intrarenal and interstitial angiotensin (Ang) II levels are due to increased AT1 receptor mediated Ang II uptake and stimulation of renal angiotensinogen (AGT) mRNA and protein expression. Augmented proximal tubule AGT production increases tubular AGT secretion and spillover of AGT into the distal nephron and urine. Increased renin formation by principal cells of the collecting ducts forms Ang I from AGT thus increasing Ang II. The catalytic actions of renin and prorenin are enhanced by prorenin receptors (PRRs) on the intercalated cells. The resultant increased intrarenal Ang II levels contribute to the genesis of chronic hypertension. © 2011 Elsevier Ltd. All rights reserved.
5-HT and the immune systemGerard P. Ahern
Volume 11, Issue 1, February 2011, Pages 29-33
The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed. © 2011 Elsevier Ltd. All rights reserved.
Ocular perfusion pressure and ocular blood flow in glaucomaA. Popa Cherecheanu | G. Garhofer | D. Schmidl | R. Werkmeister | L. Schmetterer
Volume 13, Issue 1, February 2013, Pages 36-42
Glaucoma is a progressive optic neuropathy of unknown origin. It has been hypothesized that a vascular component is involved in glaucoma pathophysiology. This hypothesis has gained support from studies showing that reduced ocular perfusion pressure is a risk factor for the disease. The exact nature of the involvement is, however, still a matter of debate. Based on recent evidence we propose a model including primary and secondary insults in glaucoma. The primary insult appears to happen at the optic nerve head. Increased intraocular pressure and ischemia at the post-laminar optic nerve head affects retinal ganglion cell axons. Modulating factors are the biomechanical properties of the tissues and cerebrospinal fluid pressure. After this primary insult retinal ganglion cells function at a reduced energy level and are sensitive to secondary insults. These secondary insults may happen if ocular perfusion pressure falls below the lower limit of autoregulation or if neurovascular coupling fails. Evidence for both faulty autoregulation and reduced hyperemic response to neuronal stimulation has been provided in glaucoma patients. The mechanisms appear to involve vascular endothelial dysfunction and impaired astrocyte-vessel signaling. A more detailed understanding of these pathways is required to direct neuroprotective strategies via the neurovascular pathway. © 2012 Elsevier Ltd.
The dual role of autophagy in cancerEeva Liisa Eskelinen
Volume 11, Issue 4, August 2011, Pages 294-300
Autophagy is a mechanism for the degradation of cytoplasmic material, damaged organelles and aggregate-prone proteins in lysosomes. Recent evidence indicates that autophagy is a tumor suppressor mechanism, which is connected to its role in the clearance of the scaffold protein p62/SQSTM1 and prevention of oxidative stress and genomic instability. However, since autophagy is a survival mechanism, cancer cells can also exploit it to survive nutrient limitation and hypoxia that often occur in solid tumors. Tumor cells can also upregulate autophagy as a response to cancer treatment, and recent studies show that inhibition of autophagy can enhance the killing of tumor cells after treatment. Interestingly, the FK506-binding protein 51 plays a role in the autophagy-linked radiation resistance of malignant melanoma. © 2011 Elsevier Ltd. All rights reserved.
Non-peptide AT2-receptor agonistsU. Muscha Steckelings | Mats Larhed | Anders Hallberg | Robert E. Widdop | Emma S. Jones | Charlotta Wallinder | Pawel Namsolleck | Björn Dahlöf | Thomas Unger
Volume 11, Issue 2, April 2011, Pages 187-192
The renin-angiotensin-system harbours two main receptor subtypes binding angiotensin II which are the AT1-receptor and the AT2-receptor. While the AT1-receptor has been a drug target in cardiovascular disease for many years, the AT2-receptor was only a subject of academic interest. This has changed with the design and synthesis of a first non-peptide, orally active AT2-receptor agonist, compound 21 (C21). First data using C21 revealed tissue protective effects and functional improvement after myocardial infarction and in hypertension-induced end organ damage, notably in a blood-pressure independent way. In all of these models, AT2-receptor mediated anti-inflammation seemed an important underlying mechanism. C21 is awaited to enter a phase I clinical study in 2011. © 2010 Elsevier Ltd. All rights reserved.
Uncoupling of endothelial NO synthase in atherosclerosis and vascular diseaseHuige Li | Ulrich Förstermann
Volume 13, Issue 2, April 2013, Pages 161-167
Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is an antihypertensive, antithrombotic and anti-atherosclerotic molecule. Hypercholesterolemia leads to a reduction in vascular NO bioavailability. This is attributed to a dysfunction of the eNOS enzyme and a reduced eNOS activity. NADPH oxidase-mediated oxidative stress leads to oxidation of tetrahydrobiopterin (BH4), the essential cofactor of eNOS. In BH 4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting eNOS to a superoxide-producing enzyme. As a consequence of eNOS uncoupling, NO production is reduced and the pre-existing oxidative stress is enhanced, which contribute significantly to atherogenesis. Therefore, pharmacological approaches that prevent eNOS uncoupling and enhance eNOS activity are of therapeutic interest. Angiotensin-converting enzyme inhibitors, AT1 receptor blockers, statins, nebivolol and resveratrol have been shown to reverse eNOS uncoupling and to stimulate eNOS activity concurrently. Molecular mechanisms of the aforementioned drugs/compounds on eNOS functionality is summarized and discussed in this review.
New developments in Toll-like receptor targeted therapeuticsDympna J. Connolly | Luke Aj O'Neill
Volume 12, Issue 4, August 2012, Pages 510-518
Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a significant amount of evidence implicates TLRs in the pathogenesis of immune diseases and cancer, and their activation occurs early in the inflammatory cascade, they are attractive targets for novel therapeutic agents. Potential therapeutics include TLR-targeted antibodies, small molecules and nucleic acid based drugs. Agonists are being tested in vaccines against hepatitis C and influenza as well as in allergic rhinitis and certain cancers. Antagonists are being tested in ischemia/reperfusion injury, systemic lupus erythematosus and psoriasis. The prospect of targeting TLRs in multiple pathologies continues to hold much promise. © 2012 Elsevier Ltd.
Cholesterol and prostate cancerKristine Pelton | Michael R. Freeman | Keith R. Solomon
Volume 12, Issue 6, December 2012, Pages 751-759
Prostate cancer risk can be modified by environmental factors, however the molecular mechanisms affecting susceptibility to this disease are not well understood. As a result of a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinically relevant therapeutic target in prostate cancer. This review summarizes the findings from human studies as well as animal and cell biology models, which suggest that high circulating cholesterol increases risk of aggressive prostate cancer, while cholesterol lowering strategies may confer protective benefit. Relevant molecular processes that have been experimentally tested and might explain these associations are described. We suggest that these promising results now could be applied prospectively to attempt to lower risk of prostate cancer in select populations. © 2012 Elsevier Ltd. All rights reserved.
Jakinibs: A new class of kinase inhibitors in cancer and autoimmune diseaseApostolos Kontzias | Alexander Kotlyar | Arian Laurence | Paul Changelian | John J. O'Shea
Volume 12, Issue 4, August 2012, Pages 464-470
Cytokines are critical for normal cell growth and immunoregulation but also contribute to growth of malignant cells and drive immune-mediated disease. A large subset of immunoregulatory cytokines uses the type I and type II cytokine receptors and pharmacological targeting of these cytokines/cytokines receptors has proven to be efficacious in treating immune and inflammatory diseases. These receptors rely on Janus family of kinases (Jaks) for signal transduction. Recently the first Jak inhibitor (jakinib) has been approved by the FDA and a second has been recommended for approval. Many other Jakinibs are likely to follow and in this brief review, we will discuss the state-of-the art of this new class of pharmacological agents. ©2012 Elsevier Ltd.
Steroid up-regulation of FKBP51 and its role in hormone signalingTiina Jääskeläinen | Harri Makkonen | Jorma J. Palvimo
Volume 11, Issue 4, August 2011, Pages 326-331
FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an important determinant of the responses to steroids, especially to glucocorticoids in stress and mood disorders and androgens in prostate cancer, raising medical and pharmacological interests in the protein and its gene. Recent studies have revealed the molecular mechanisms by which the androgens and the glucocorticoids via their nuclear receptors elicit the robust up-regulation of the FKBP51 gene. Several polymorphisms in the FKBP51 gene have been associated with the mood disorders and differences in glucocorticoid sensitivity. The polymorphisms may contribute to the steroid up-regulation of the FKBP51 and thus influence the regulatory loops in steroid signaling. © 2011 Elsevier Ltd. All rights reserved.
Oxidative stress and mitochondrial dysfunction in glaucomaVicki Chrysostomou | Fatemeh Rezania | Ian A. Trounce | Jonathan G. Crowston
Volume 13, Issue 1, February 2013, Pages 12-15
Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress is recognized as a common pathologic pathway in many neurodegenerative diseases. Recent reports have also demonstrated oxidative stress in ocular tissues derived from experimental glaucoma models and clinical samples. There is also accumulating evidence pointing to mitochondrial dysfunction being present in some glaucoma patients. Thus oxidative stress from mitochondrial dysfunction may also play a causal role in glaucoma. The mechanisms by which oxidative stress may induce retinal ganglion cell loss in glaucoma are not fully understood but could include direct neurotoxic effects from ROS or indirect damage from oxidative stress-induced dysfunction of glial cells. This review will consider the evidence for the presence of oxidative stress in glaucoma; the mechanisms by which oxidative stress may contribute to disease pathogenesis; and also consider therapeutic approaches that target oxidative stress as a means of protecting against optic nerve degeneration. © 2012 Elsevier Ltd.
The role of TLRs in neutrophil activationLynne R. Prince | Moira K. Whyte | Ian Sabroe | Lisa C. Parker
Volume 11, Issue 4, August 2011, Pages 397-403
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection and inflammation to provide early defence against invading microorganisms. This function is facilitated by the expression of Toll-like receptor (TLR) family members by neutrophils, allowing the recognition of an extensive repertoire of pathogen-associated molecular patterns (PAMPs) and thus triggering the response to invading pathogens. TLR activation leads to important cellular processes including reactive oxygen species (ROS) generation, cytokine production and increased survival, all of which can contribute to the pathogenesis of chronic inflammation when signalling becomes dysregulated. In turn, inflammation and tissue injury results in the release of endogenous TLR ligands, known as damage-associated molecular patterns (DAMPs), which are a rapidly growing class of potent inflammatory stimuli. DAMPs act in an autocrine manner, alerting the host of damage, but can also amplify inflammation leading to further tissue damage. This review highlights recent literature on neutrophil TLR function and regulation during disease, and provides an overview of the recently emerging area of neutrophil responses to DAMPs. © 2011 Elsevier Ltd. All rights reserved.
Protein-protein interactions as druggable targets: Recent technological advancesAlicia P. Higueruelo | Harry Jubb | Tom L. Blundell
Volume 13, Issue 5, October 2013, Pages 791-796
Classical target-based drug discovery, where large chemical libraries are screened using inhibitory assays for a single target, has struggled to find ligands that inhibit protein-protein interactions (PPI). Nevertheless, in the past decade there have been successes that have demonstrated that PPI can be useful drug targets, and the field is now evolving fast. This review focuses on the new approaches and concepts that are being developed to tackle these challenging targets: the use of fragment based methods to explore the chemical space, stapled peptides to regulate intracellular PPI, alternatives to competitive inhibition and the use of antibodies to enable small molecule discovery for these targets. © 2013 Elsevier Ltd. All rights reserved.
Improving known classes of antibiotics: An optimistic approach for the futureKaren Bush
Volume 12, Issue 5, October 2012, Pages 527-534
New antibiotic agents are desperately needed to treat the multidrug-resistant pathogens that continue to emerge at alarming rates. Many of the agents that have entered full clinical development since 1995 have been members of previously accepted classes of antibiotics. Among these are a new aminoglycoside (plazomicin), anti-MRSA cephalosporins (ceftobiprole and ceftaroline), a monocyclic β-lactam (BAL30072), the β-lactamase inhibitor combination of tazobactam with the anti-pseudomonal cephalosporin ceftolozane, β-lactam combinations with new non-β-lactam inhibitors (MK-7655 with imipenem, and avibactam with ceftazidime and ceftaroline), new macrolides (cethromycin and solithromycin), oxazolidinones (tedizolid phosphate and radezolid), and quinolones (delafloxacin, nemonoxacin and JNJ-Q2). Resistance and safety issues have been circumvented by some of these new agents that have well-established mechanisms of action and defined pathways leading toward regulatory approval. © 2012 Elsevier Ltd.
Antioxidant pharmacological therapies for COPDIrfan Rahman | William MacNee
Volume 12, Issue 3, June 2012, Pages 256-265
Increased oxidative stress occurs in the lungs and systemically in COPD, which plays a role in many of the pathogenic mechanisms in COPD. Hence, targeting local lung and systemic oxidative stress with agents that modulate the antioxidants/redox system or boost endogenous antioxidants would be a useful therapeutic approach in COPD. Thiol antioxidants (N-acetyl-l-cysteine [NAC] and N-acystelyn, carbocysteine, erdosteine, and fudosteine) have been used to increase lung thiol content. Modulation of cigarette smoke (CS) induced oxidative stress and its consequent cellular changes have also been reported to be effected by synthetic molecules, such as spin traps (α-phenyl-N-tert- butyl nitrone), catalytic antioxidants (superoxide dismutase [ECSOD] mimetics), porphyrins, and lipid peroxidation and protein carbonylation blockers/inhibitors (edaravone and lazaroids/tirilazad). Preclinical and clinical trials have shown that these antioxidants can reduce oxidative stress, affect redox and glutathione biosynthesis genes, and proinflammatory gene expression. In this review the approaches to enhance lung antioxidants in COPD and the potential beneficial effects of antioxidant therapy on the course of the disease are discussed. © 2012 Elsevier Ltd. All rights reserved.
5-HT 6 receptor and cognitionXabier Codony | Jose Miguel Vela | Maria Javier Ramírez
Volume 11, Issue 1, February 2011, Pages 94-100
Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT 6 receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antagonists, but also 5-HT 6 receptor agonists improve learning and memory in animal models. There is even an antagonist, SB-742457, that has completed phase II trials for the treatment of Alzheimer's disease. In addition to describe preclinical and clinical evidence of the effect of 5-HT 6 receptor compounds on cognition, this article will also focus on the purported biochemical and neurochemical mechanisms of action by which 5-HT 6 receptor compounds could influence cognition in health and disease. © 2011 Elsevier Ltd. All rights reserved.
Recent advances in osteosarcomaSander M. Botter | Dario Neri | Bruno Fuchs
Volume 16, Issue 1, January 2014, Pages 15-23
Although osteosarcoma (OS) is a rare malignancy, it is ranked among the leading causes of cancer-related death in the pediatric age group. The cancer's low prevalence and its large tumor heterogeneity make it difficult to obtain meaningful progress in patient survival. In this review we present an overview of current clinical trials which largely focus on stimulation of the immune system or rely on the inhibition of kinases such as Src and mTOR. The potential efficacy of tumor-targeted TNFalpha is discussed, as well as the importance of preclinical validation of new targets. To improve the success of future clinical trials, clinicians and basic researchers need to intensify their exchange. Finally, a case is made for individualized treatment of OS patients, based on interdisciplinary cooperation in dedicated Sarcoma Centers.
5-HT and depression: Is the glass half-full?Trevor Sharp | Philip J. Cowen
Volume 11, Issue 1, February 2011, Pages 45-51
Mood disorders such as major depression are common illnesses with considerable morbidity and significant mortality. A long-standing theory is that a breakdown in brain serotonin (5-hydroxytryptamine; 5-HT) signalling is critically involved in the symptoms and drug treatment of clinical depression. However, the nature of this 5-HT defect has proved to be frustratingly elusive, and it remains unclear how the 5-HT signalling effects of antidepressant drugs might alter neuropsychological mechanisms to bring about relief of depressed mood. This article highlights recent discoveries that advance our understanding of how 5-HT-evoked changes at molecular, cellular and neuropsychological levels might interact to alleviate the symptoms of clinical depression. © 2011 Elsevier Ltd. All rights reserved.
Prolyl cis/trans isomerase signalling pathways in cancerMartin Theuerkorn | Gunter Fischer | Cordelia Schiene-Fischer
Volume 11, Issue 4, August 2011, Pages 281-287
It is an emerging view that in many cases cell signalling relies on slow conformational interconversions of the backbone of key proteins as exemplified by the prolyl cis/trans isomerization, and that prolyl cis/trans isomerases (PPIases), such as cyclophilins, FK506-binding proteins and the parvulin-like Pin1, serve to integrate temporally and spatially protein conformers with signalling events. The causal relationship between prolyl cis/trans isomerization catalysis, malignant transformation and tumour progression is not yet fully understood because of the pleiotropic biochemical effects characterizing these enzymes. However, recent studies on the role of cyclophilins and Pin1 indicate that PPIases utilize isomerization catalysis on client proteins under physiological and pathophysiological conditions. This knowledge could offer new cancer intervention strategies based on the development of isoenzyme-specific, tissue-specific and organelle-specific PPIase inhibitors. © 2011 Elsevier Ltd. All rights reserved.
Schizophrenia: From dopaminergic to glutamatergic interventionsMarc Laruelle
Volume 14, Issue 1, February 2014, Pages 97-102
Schizophrenia might be considered a neurodevelopmental disease. However, the fundamental process(es) associated with this disease remain(s) uncertain. Many lines of evidence suggest that schizophrenia is associated with excessive stimulation of dopamine D2 receptors in the associative striatum, with a lack of stimulation of dopamine D1 receptors in prefrontal cortex, and with modifications in prefrontal neuronal connectivity involving glutamate transmission at N-methyl aspartate (NMDA) receptors. This article, whilst briefly discussing the current knowledge of the disease, mainly concentrates on the NMDA hypofunction hypothesis. However, there are also potential consequences for a Dopamine imbalance on NMDA function. Thus, it is proposed that schizophrenia has a complex aetiology associated with strongly interconnected aberrations of dopamine and glutamate transmission.


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In its recent special section, Tradiciones, the Optic failed to credit Melissa Greene as the photographer for the cover shot of Plaza Park after a snowfall.
New Mexico Highlands University presents "Preserving Your Historical Records: An Archival Holdings Maintenance Workshop"from 9 a.m. to 4 p.m. on Dec. 8 in the Margaret Kennedy Alumni Hall, 905 University Ave.
The university's Office of Research and Sponsored Projects and Donnelly Library are sponsoring the workshop.
Participants will learn the basics of how to care for and store historical records.
• Story Time at Carnegie Library, 10:30 a.m. and 3:30 p.m., Wednesday, Nov. 30, in the children's area of the public library. This week's book is "Dora and The Unicorn King" by Ellie Seiss and the character theme is "Dora the Explorer" The theme for the month is "Popular Characters." All programs are free and open to the public.
As November comes to a conclusion, so goes National Adoption Month, a time to highlight the need for children and youth in foster care to find permanent homes with loving adults. According to the U.S. Department of Health & Human Services, there are 107,000 young people in the U.S. waiting for such a home. A couple of weeks ago, however, there were six fewer kids in the system — thanks to the actions of a single man, an attorney in Farmington.
For years, Readers Digest carried a feature called "Pardon, Your Slip is Showing," highlighting journalistic "slips" that appeared in the American press.
When Las Vegas attempted a commercial airline and offered rides to families at a penny a pound, there were quite a few takers. But as interest dropped off, apparently the airline sponsored a promotion, which provided breakfast before each flight.
Joe Harge has done nothing but win since taking the helm of New Mexico Highlands University men's basketball in 2008, and he's looking to keep that going in 2011-12.
His Cowboys went 19-8 overall and 15-7 in the Rocky Mountain Athletic Conference last season, just missing a third consecutive 20-win mark. Harge inherited a program that had gone 1-25 in 2007-08, overhauled the roster and led Highlands to 20-8, 20-11 and 19-8 records over the last three seasons.
If recent history is any indicator, Fort Lewis and Metro State figure to again battle it out for supremacy in the Rocky Mountain Athletic Conference women's basketball ranks, leaving everyone else to fight over third place.
While it's unclear whether her New Mexico Highlands team is ready to crash the party, coach Tiffany Darling may be feeling her squad is better than the 12th place prediction it received in a preseason poll.
Copyright © 2016
The Las Vegas Optic is your source for local news, sports, events, and information in San Miguel County and Las Vegas, NM, and the surrounding area.


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ABC's "Scandal" beats Panthers tilt
Don't tell me what happened on last night's "Scandal," though I hear it was a shocker.
Also, somewhat shocking, is the fact that "Scandal," seen locally on WISN-TV (Channel 12) beat the NCAA baskeball games in overnight ratings, including the UW-Milwaukee Panthers game against Villanova.
"Scandal" had a 6 rating, while the TBS telecast of the UWM game earned a 5.2 rating on TBS. »Read Full Blog Post
Badgers broadcasts move to WRIT, WOKY, WISN
Clear Channel announced it has entered a five-year contract with Learfield Sports to carry Wisconsin Badgers sportscasts on its stations WOKY-AM (920), WRIT-FM (95.7) and WISN-AM (1130).
Previous rights holder WTMJ-AM (620), which has carried the broadcasts since 1927, recently declined to renew its agreement with Learfield Sports.
Beginning in 2014, Badger football and men's basketball will air on WOKY and WRIT. It will be the first time Badgers games will be available on the FM dial. »Read Full Blog Post(30)
Stephen Colbert's bracketology: Yes to Marquette, no to UW
In this clip from a 2007 episode - with outdated references to Bobby Knight and then President Bush - Stephen Colbert helps college basketball fans fill out their NCAA brackets. Watch and learn why he says yes to Marquette and no to the Badgers.
The Colbert Report
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Katie Lee's Peanut Butter and Jelly Thumbprint Cookies — 12 Days of Cookiesby Cameron Curtis in Holidays, December 12th, 2014
It's time for 12 Days of Cookies, Food Network's annual virtual cookie swap. Each day, visit us here on FN Dish for a peek at new holiday cookies, party-planning tips and top techniques from your favorite Food Network chefs for rolling, spooning, slicing, baking and decorating delicious sweet treats to give — or keep.
Katie Lee's thumbprint cookies can be made entirely in the food processor. Pulse unsalted roasted peanuts with old-fashioned oats as the base for a crumbly dough that will taste just like your favorite sandwich once a dollop of jelly is added after baking.
Get Katie's Peanut Butter and Jelly Thumbprint Cookies recipe, and check out 12 Days of Cookies for dozens more recipes and holiday baking inspiration. Then, join the conversation: Tell us what you're baking this season and what your all-time favorite cookie is.


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Casillas proves worth
Former UW star got second chance
Fort Lauderdale, Fla. — New Orleans linebacker Jonathan Casillas did not get drafted last April despite showing he could run like a wide receiver.
He has an idea what went wrong.
"I don't know exactly what the coaches were saying to the scouts, but I don't think they helped me out too much at the University of Wisconsin," he said this week as he prepared with his teammates for Super Bowl XLIV on Sunday.
Casillas bears some responsibility for the poor ending to his once promising start with the Badgers. He was cited for driving a moped while under the influence of alcohol less than a week before the team's 2008 season opener.
Later in the year, Casillas chose to sit out the team's bowl game against Florida State because he felt a knee injury that he had played through all year had gotten bad enough that he would be risking his NFL future. He said a lack of communication between him and school officials created some hard feelings that might have led to less-than-flattering reports about him.
"I guess something along the way went wrong," Casillas said. "It might be my fault. It doesn't really matter whose fault it is now. But basically, it was a problem that I didn't play in the bowl game."
A year later, Casillas doesn't have the money in his pocket he would have if he had been drafted, but he couldn't ask for a much better turnaround in fortune than what has occurred with the Saints. After flashing the ability that made him such a promising player at Wisconsin, he became an instant contributor, playing on special teams and starting two games at linebacker.
He is so athletic that at 6-1, 227 pounds, he serves as a gunner on the punt coverage team, a position usually reserved for defensive backs. In his two starts at the end of the season, he totaled 19 tackles, including nine solos.
"This kid has been a great, great surprise for us," Saints linebackers coach Joe Vitt said. "He's a core special teams player. He's a 4.4 (-second) 40 (-yard dash) guy and has made plays as a gunner. We think he has a really bright future in the league."
It didn't appear that way in August of 2008. when Casillas was cited for driving a moped while under the influence of alcohol. The arrest came a week before the season opener.
Although Casillas wasn't scheduled to play because of the knee injury, he was supposed to be a senior leader, but the arrest surely didn't sit well with his coaches. There's no question it raised red flags for teams considering him in the draft.
"He had a little speckled background, got into some trouble his senior year," Vitt said. "But really it was nothing any of us didn't do our senior years."
The Saints did their homework on Casillas. They did not give him a draftable grade, but he was a high-priority free agent and they had to compete with a number of teams for his services.
"We talked to him the whole draft day, saying, 'Listen, if you're not drafted we would like to have you here as a free agent,' " Vitt said. "We built up a great relationship with his mother, telling her we'd take great care of him in New Orleans."
Casillas said he's put his Wisconsin troubles behind him and is happy with the eventual outcome.
Casillas stands by his decision not to play in the bowl game. He said an MRI taken in October of 2008 showed he had two tears in meniscus in his knee and that another MRI taken before the bowl game showed they had gotten worse.
His mother, a nurse, set him up with a specialist, who told him he needed surgery and would risk further injury if he played without it. He said he spoke with coach Bret Bielema and athletic director Barry Alvarez, but the two sides never could see eye to eye.
He said he ended up paying for the surgery himself.
"That's all behind me, it's all in the past," he said. "I don't hold any grudges over nobody. I had a great career at Wisconsin. I made a lot of friends. I'm appreciative of everything coach Bielema, Alvarez, (defensive coordinator Dave) Doeren, everything they've done for me.
"It's a blessing to be here," he said of New Orleans.
Missing Marvin
It has not surprised Colts wide receiver Reggie Wayne that he has not heard from former Colts star Marvin Harrison — the guy whose work habits he copied and whose locker stood next to his for eight years — since Harrison was released in the off-season.
"Our lockers were next to each other and we very seldom talked then," Wayne said. "That's the way it is. You just have to understand his character. It's not a surprise."
Wayne said that Harrison set an example for him with his 100% effort in practice, demand for every practice rep and hunger for the ball. But when it came to chatting, it rarely happened.
"He's just to himself," Wayne said. "He has a lonely soul. He's anti-social. That's what makes him. If you see him all of a sudden talking to the media and doing things like that, that's an imposter. That's not him. He's going to keep the same make-up he's had since Day One. I guess that's what works for him."
Practice, practice
The most significant development for either team was that Colts starting left guard Ryan Lilja missed practice with a back injury.
Coach Jim Caldwell said he thought Lilja would be ready for Sunday.
Defensive end Dwight Freeney (ankle) and cornerback Jarraud Powers (foot) both did not participate in practice. Freeney wore a wrap around his right foot and ankle while walking around in flip-flops during media sessions.
Left is right
Freeney was asked whether moving from the right side to the left would allow him to play because he would be able to push off with his good foot.
"Actually, it really doesn't matter because the way I play I do move both ways, cutting and moving both ways," he said. "I don't think the other side would help any more, I would still have to make a move."


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By now your baby is urinating approximately several cups of urine a day into the amniotic fluid. He or she is also swallowing amniotic fluid, which is completely replaced several times a day. Excess fluid in the amniotic sac (known as polyhydramnios) may mean that the baby isn't swallowing normally or that there is a gastrointestinal obstruction. Inadequate fluid in the amniotic sac (oligohydramnios) may mean that the baby isn't urinating properly and could indicate a problem with the kidneys or urinary tract. Your health care provider will measure your levels of amniotic fluid as part of your routine ultrasound.
Have you decided whether to breastfeed or formula feed your baby? Although the American Academy of Pediatrics (AAP) recommends breast milk as the best form of infant nutrition, the decision about how to feed your child is a personal one. Talk to your health care provider or a lactation consultant if you need more information before making your choice.
The milk glands in your breasts may have started to make colostrum by now. Colostrum is the pre-milk that provides your baby with calories and nutrients for the first few days before your milk comes in if you plan to breastfeed. For some women, it is thin and watery. For others, it is thick and yellowish. If you notice your breasts leaking colostrum, you can buy disposable or washable breast pads to protect your clothing.
Note: All information is for educational purposes only. For specific medical advice, diagnoses and treatment, consult your doctor.
© 1995–2015 The Nemours Foundation/KidsHealth. All rights reserved.
Find out by selecting your child's symptom or health condition in the list below:
In This Issue: Summer 2016
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Mothers are there to help us grow, support us and be our rock when we're in need. This special helps us honor and celebrate mothers with heartwarming patient stories from Seattle Children's.
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Cyberbullying is bullying that happens using electronic technology. It can include mean or embarrassing photos, videos or comments posted on social media or sent by text. Sometimes teens don't want to admit to experiencing cyberbullying because they think that bullying only happens to younger kids. Ask your child to tell you about their...
From healing paws to poetry programs, see the innovative and inspiring ways Seattle Children's goes beyond traditional medicine to heal kids. The KING 5 HealthLink special "Healing the Spirit" is hosted by Jean Enersen.


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CHICAGO - Edgar Renteria hit a grand slam, Jim Edmonds homered twice and the Cardinals roughed up Mark Prior in a 12-4 victory over the Chicago Cubs that showed last year's feud between the NL Central rivals definitely is not over.
Edmonds finished 3-for-4 with four RBIs and a walk. Scott Rolen didn't homer for the first time in three days, but he had an RBI to add to his major league-high total of 63. W: Morris (6-5). L: Prior (0-1).
Blue Jays 4, Dodgers 0: In Toronto, Miguel Batista pitched a four-hitter for his third career shutout, leading Toronto over Los Angeles.
Batista set a season-high with seven strikeouts and walked two in his first shutout since last July 18 against San Diego. Batista has allowed three runs in his last three outings, lowering his ERA to 4.20, and has won four of his last six starts after going winless in his first seven. W: Batista (4-4). L: Lima (4-2).
Indians 8, Marlins 1: In Cleveland, Jake Westbrook pitched eight impressive innings and Casey Blake homered to help Cleveland finally defeat Florida.
The Indians got past Florida for the first time since winning Game 6 of the 1997 World Series. The Marlins won Game 7 in 11 innings, swept a three-game series at home in 2002 and took the opener of this three-game set Tuesday night on two ninth-inning homers off the foul pole at Jacobs Field. W: Westbrook (5-2). L: Burnett (0-2).
Yankees 7, Rockies 5: In New York, Derek Jeter returned from a three-game absence to hit a go-ahead home run in the seventh inning, and the Yankees overcame the loss of starter Kevin Brown by rallying past Colorado.
The Yankees won their 12th straight interleague game, the longest streak in the majors since AL vs. NL regular-season play began in 1997. Colorado lost its fourth in a row overall.
Jeter, sidelined by tightness in his left groin, Bernie Williams and Gary Sheffield homered as New York came back from an early 5-0 hole. The Yankees won when trailing by at least four runs for the sixth time this season; they did not do it once last year. W: Quantrill (5-2). L: Kennedy (4-4). S: Rivera (25).
Orioles 8, Diamondbacks 2: In Baltimore, Miguel Tejada hit a tiebreaking, three-run homer in the seventh inning and Luis Matos added a two-run shot, powering Baltimore past Arizona.
Melvin Mora scored a career-high four runs for the Orioles, who won for only the sixth time in 18 games.
Baltimore batted around in a five-run seventh to take a 7-2 lead. Stephen Randolph, who came in with a 1.98 ERA, walked Brian Roberts and Mora before Tejada hit a 3-1 fastball over the right-field scoreboard. W: Parrish (4-2). L: Randolph (1-1).
Twins 5, Mets 3: In Minneapolis, Johan Santana struck out 10 and walked none, allowing one run and six hits in seven inning to end his four-game losing streak. Joe Nathan got four outs for his 16th save.
Jacque Jones hit a three-run homer, and Matthew LeCroy followed with a home run as Minnesota won its third straight. W: Santana (3-4). L: Trachsel (5-5). S: Nathan (16).
Devil Rays 4, Giants 3: In St. Petersburg, Fla., Jose Cruz Jr. hit a two-out, bases-loaded single in the 10th inning after Tyler Walker walked the bases loaded.
Danys Baez pitched two innings for the victory after blowing a save for the first time in 12 opportunities.
The Giants scored twice in the ninth, with pinch-hitter Michael Tucker singling home a run and the other crossing when Duston Mohr grounded into San Francisco's fifth double play. W: Baez (2-1). L: Walker (4-1).
Phillies 13, White Sox 10: In Chicago, Bobby Abreu homered twice and Eric Milton won his third straight start to lead Philadelphia over the White Sox.
Abreu hit a solo home run in the first and a two-run shot in a seven-run fourth for the Phillies, who had lost six of eight. Jim Thome added his third homer in two games for Philadelphia. W: Milton (8-1). L: Garland (5-3).
Tigers 4, Braves 2: In Detroit, Eric Munson and Carlos Guillen homered, sending Detroit to a victory over Atlanta.
Craig Dingman got his first major league win, pitching three scoreless innings of relief in a game delayed by rain for 2 hours, 24 minutes in the second inning.
Chipper Jones and Eli Marrero homered for Atlanta, which dropped back to .500. W: Dingman (1-0). L: Thomson (5-3). S: Urbina (8).
Padres 8, Red Sox 1: In Boston, Brian Lawrence pitched five innings of shutout ball to help San Diego spoil Nomar Garciaparra's return to the Red Sox with a victory.
Neither Lawrence nor Garciaparra remained in the game after a rain delay of 2 hours, 21 minutes, which came in the middle of the sixth. Only a few thousand fans stayed for the end of the game at 12:12 a.m. EDT. W: Lawrence (8-3). L: Arroyo (2-4).
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Prime area for office or medical building; city water & sewer available; just off I-75/US-90; several lots available
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Rent Writing Matters, Tabbed Preliminary Edition (Comb-bound) 1st edition today, or search our site for other textbooks by Rebecca Moore Howard. Every textbook comes with a 21-day "Any Reason" guarantee. Published by McGraw-Hill Humanities/Social Sciences/Languages.
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Testing the Expectations Hypothesis in the Brazilian Term Structure of Interest Rates
In this paper the Expectations Hypothesis (EH) is tested using cointegration techniques, for maturities ranging from 1-month to 12-months, for the Brazilian market. We found evidence suggesting that for the period 1995-2001, the cointegration implication generally seems to hold. We also found strong evidence supporting causality from short to long rates and also in the opposite direction. Empirical evidence supports the expectations theory of the term structure of interest rates. However, when using multivariate cointegration tests we reject the unbiasedness hypothesis implied in the pure EH.
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|Date of creation:
|Nov 2001
|Date of revision:
|Publication status:
|Published in Revista Brasileira de Finanças, Vol. 1, no. 1, (2003).
|Contact details of provider:
| Web page: http://www.bcb.gov.br/?english
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Google has used its Jacquard technology to weave conductive threads into a Levi's jacket, turning its sleeves into touch-sensitive panels that can be used to control electronic devices (+ movie). More »
VR goggles combined with hand-held controllers offers architects "a whole new way of designing"
New virtual reality tools will allow architects and designers to create buildings and products intuitively in 3D space around them, according to the director of visualisation studio VRtisan (+ movie). More »
Sebastian Wrong's Font Clock "wakes people up with a real crack" at midnight
Most Loved: London designer Sebastian Wrong reflects on living with the distinctive sound made by his 2007 Font Clock for Established & Sons in the latest movie in our exclusive video series. More »
Delicate brass framework divides spaces inside Neri&Hu's Sulwhasoo flagship store
Keiichi Matsuda's Hyper-Reality film blurs real and virtual worlds
London designer Keiichi Matsuda has released a short movie depicting a futuristic scenario where digital media and the physical world have merged to create a kaleidoscopic "hyper reality"(+ movie). More »
Girl attempts to "tame the evil that lurks inside herself" in K Flay music video
Fabric-cast concrete is the construction method of the future, say designers
Benjamin Hubert's 3D-printed wheelchair to launch during Clerkenwell Design Week
Clerkenwell Design Week 2016: Benjamin Hubert's London studio Layer has unveiled photographs and a movie of its made-to-measure, 3D-printed wheelchair, ahead of its launch next week. More »
Hansgrohe opens interactive showroom The Water Studio in Clerkenwell
Trees grow through the floors of Julio Hernández house by Roof Arquitectos
A "forest" of sweet gum trees grows through openings in the concrete slabs of this house in Morelia, Mexico, by Roof Arquitectos, providing an alternative to a central courtyard (+ movie). More »
MIT researchers create 3D-printed fur, opening up "a new design space"
Researchers from the Massachusetts Institute of Technology have developed a method for 3D printing artificial hair, allowing them to print everything from paintbrushes to fake fur (+ movie). More »
London's AA School taps into robotic construction trend by launching specialist course
London's Architectural Association has released a film showing its first major foray into robotic construction, and has revealed it will this year launch a new course focussed on digital fabrication (+ movie). More »
Martino Gamper creates drum kits for Nike with Flyknit skins
Milan 2016: designer Martino Gamper explains how he repurposed the Flyknit material Nike uses in its shoes to create drum skins in our next movie from the sports brand's The Nature of Motion exhibition in Milan. More »
Hyperloop could completely transform how cities are planned says Bjarke Ingels
Bjarke Ingels's firm has been announced as one of the architectural partners that will help build infrastructure for the Hyperloop high-speed transportation system, in the same week as the latest test of its propulsion technology (+ movie). More »
Francesco Faccin creates furniture with bronze planks cast to look like wood
Milan 2016: Italian designer Francesco Faccin's Bronzification collection features furniture made from panels of bronze with the texture and appearance of wooden planks (+ movie). More »
Denise Schindler to become world's first Paralympic cyclist to use 3D-printed prosthesis
Future Makers: German athlete Denise Schindler is working with Autodesk to become the first cyclist to compete with a fully 3D-printed prosthetic leg at the Rio 2016 Paralympic Games (+ movie). More »
Movie documents MVRDV's pioneering technique for creating glass brick facades
This movie shows the installation of MVRDV's Crystal Houses – a Chanel store featuring a traditional facade replicated with glass bricks that are "stronger than concrete". More »
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On 11/30/2009 06:12 PM, Dan Williams wrote:
On Mon, 2009-11-30 at 09:55 +0000, Terry Barnaby wrote:On 11/29/2009 11:30 PM, Dan Williams wrote:On Sat, 2009-11-28 at 09:10 +0000, Terry Barnaby wrote:On 11/28/2009 08:35 AM, Rakesh Pandit wrote:2009/11/28 Terry Barnaby wrote:If the NetworkManager service is running, but not managing the current network connection, then Firefox starts up in offline mode. Is this a bug in NetworkManager or Firefox ?This is odd behaviour and needs to be fixed. I would suggest open up a bug against firefox. I know one can change toolkit.networkmanager.disable preference, but it is a PITA for our users. One of use cases is: Sometime network manager does not connect me via my CDMA usb modem (in case signal is weak), but wvdial does and once I switch from NM to wvdial, my firefox gets to offline mode, which I don't expect it to as I am connected.Ok, filed as: 542078NetworkManager is intended to control the default internet connection. If NetworkManager cannot control the default internet connection, then you may not want to use NetworkManager. In your case, you're using a mobile broadband device. The real bug here is that for whatever reason, NM/MM aren't connecting your modem, and we should follow up on that bug instead. DanI am not using a mobile broadband device. The network connection my systemsMy mistake. I guess it was Rakesh Pandit who was using a CDMA 3G connection.use is not just the Internet it is a local network LAN connection that also serves the internet. Most of my systems use a local network server which provides NIS, /home and /data using NFS and VPN etc. I normally use the service "network" to bring up wired or wireless networking for this. Fedora, by default, uses NetworkManager to manage all network devices though. I use the service "network" as, for some reason, the NetworkManager service is started after the netfs and other services are started. Is there a reason for this ??No particular reason, in fact that looks like a bug. NM no longer depends on HAL, but that dependency is still in the initscript, which looks like it pushes NM later than netfs. But in reality, you're looking for a dependency based initsystem which we don't quite yet have. There are already scripts that kick netfs to mount stuff when NM brings the network up (/etc/NetworkManager/dispatcher.d/05-netfs), so you get asynchronous bootup *and* your mounts. The rest of the system, if it requires something from the mounted directories, needs to be smart enough to know that. If you need to, you can set NETWORKWAIT=yes in /etc/sysconfig/network, which causes the NetworkManager initscript to block until a network connection is brought up, or 30 seconds have passed.I can obviously turn of the NetworkManager service, which I have done on the desktop systems. However, I also have a few Laptops that can roam. In F11 and before I have used the network and NetworkManager services. When the laptop boots away from home, the "network" service fails and I can then use the NetworkManager service to connect to whatever wireless network or G3 network is available. It does seem sensible to me that the "system" provides applications with info on if the network is up (not just the Internet). The NetworkManager service seems the place to do this and it looks like the applications are starting to use it for this purpose. So maybe a generic NM "isNetworkUp()" API call is called for ?See the other mail; the problem with a generic isUp() is that it simply says hey, is there a connection? It doesn't provide enough information about the networking state of the system for anything to make an intelligent decision about anything. It's a "hey I'm connected to something" but there's no information about *what* you're connected to; whether it's a secure home network, whether it's a slow 3G network, whether it's billed by the minute or the hour or unlimited, etc. Dan
Hi, Thanks for the info. I would have thought that a generic isUp() is good enough for the likesof Firefox and Pidgen though to decide if to start offline. Being connected to a Network is probably all you need, you may be accessing an Intranet as all
my systems Firefox home pages do ... Anyway, following your email (And notes in Bugzilla) I thought I'd try and use NM properly for my config. However I have a problem, which may be a bug. I have turned off the Network services and turned on NetworkManger. I have two main network interfaces eth0 (wired) and eth1 (Wifi), both are set to be managed by NM and to start at boot. I have also added NETWORKWAIT=yes in /etc/sysconfig/network. When I boot with this the network (eth1 (eth0 is disconnected)) does not come up at boot. There is a message stating a failure on the line where it is waiting for the network to come up. When I log in as a local user the network then comes up ... I also note that, before the user is logged in, I cannot start the network with "service network start" and the WiFi light is off. It looks like NM has done something like powered down my WiFi chip ? (Intel Corporation PRO/Wireless 2915ABG IBM Thinkpad R52) Another thing, I would need NETWORKWAIT=yes as I have ypbind enabled. Maybe ypbind should be modified to not start when the network is down and also added to /etc/NetworkManager/dispatcher.d ? Cheers Terry


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Celebrate your heros with this favor box.
The Attention All Heroes Personalized Favor Box can hold all of your candy and treats from the party. Each cardstock Heroes Favor Box measures approximately 6 inches wide x 6 3/4 inches high x 3 inches deep. Best of all, you can personalize these boxes with your own text. Easy assembly.
Please allow ample time for delivery. Our ship date for this product is noted in your shopping cart. Many items are shipped separately, so please allow extra time for these items to arrive. Shipping charges are based on the value of the merchandise and not the number of shipments. For additional shipping information, contact our Customer Service Department at (email@example.com or 1-800-227-2789).


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MOBILE, Alabama -- Five years ago, Airbus executives gave Mobile Mayor Sam Jones a red silk tie speckled with tiny airplanes, and he'd held on to it, looking forward to the day that he could wear it to celebrate good news.
Monday, he got his chance, as Airbus formally announced its intention to build an aircraft assembly plant in Mobile. When the facility reaches full capacity, it will bring 1,000 new jobs.
In the short term, the city will benefit from 3,000 jobs associated with the construction of the company's $600 million investment at the Brookley Aeroplex four miles south of downtown.
The region can expect a further 4,000 jobs as suppliers start to migrate to the area, Airbus Chief Executive Fabrice Bregier told reporters Monday.
City officials said that they hope the Airbus announcement would be a turning point for Mobile, erasing any negativity about the city's prospects.
The last time that Jones wore the airplane tie, in February, 2011, the news wasn't so good. That was the day that the European Aeronautic Defence and Space Co., Airbus' parent, lost out on a contract to build refueling tankers for the U.S. Air Force. The Pentagon opted instead to award the contract to Boeing Co., Airbus chief rival in the commercial jet industry.
When that deal fell apart, many thought that Mobile's chances of building jets went with it.
State and local officials, though, didn't give up, said Larry Wettermark, Mobile's city attorney and Jones' representative during many of the negotiations with EADS and Airbus. The very night that the tanker dream evaporated, another materialized, he said.
The government officials had a late night with EADS officials and agreed, after a long discussion, to keep their incentives packages intact for courtship of Airbus instead of reallocating the money to other projects, Wettermark said.
The key was getting all parties — state, county and city — to sit tight, Jones said. Everyone recognized the transformative nature of the Airbus opportunity, but with the economy in the tank, there was temptation to dangle the incentives to other investors, he said.
"The big question became, 'How long? How long is it going to take to make this happen?'" Jones said.
Jones said that Airbus always wanted to come to Mobile, but the company had be sure that, down to the last detail, that it made business sense.
Thus, Wettermark said, the city had to do everything it could to anticipate and clear away all possible Airbus doubts. That meant going over every aspect of the city's infrastructure as it related to Airbus' future home at Brookley and the company's logistical needs.
Would the turn radii and street clearances between the waterfront and the airport accommodate large airplane parts? What utilities would need to be moved and who would pay for them? What about alternate routes for shipments?
All those questions and more had to be answered, Wettermark said.
'It's a tremendous shot in the arm'
Finally, within the last few weeks, Airbus made its decision, Jones said.
Now that they can finally talk about it, local officials say they hope that the Airbus coup will reverse what has seemed at times to be a stream of bad news for the city.
Starting with the loss of the tanker contract, continuing through Carnival Cruise Line's pullout and, most recently, grim forecasts for the city's budget, Mobile needed a win.
"It's a tremendous shot in the arm," said Councilwoman Gina Gregory. The key now, she said, is to make the city as business friendly as possible so suppliers bring more jobs to Mobile instead of to competing communities in the area.
Gregory said that Mobile also must make itself more attractive to potential residents so workers who come to the area to take new jobs don't just head to the Eastern Shore.
Councilwoman Bess Rich was optimistic: In the short term, even just the announcement itself is likely to boost the real estate market, she said.
Councilman Jermaine Burrell, whose district includes Brookley, said that the project has the potential to dramatically change the lives of his constituents by raising their property values and offering jobs.
"This is going to be the catalyst for the redevelopment that we need," he said.


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- Overview
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Well, a table of contents as we created in the previous lesson usually appears at the beginning of the document and we'll order entries by page number, an index usually appears at the end and lists item alphabetically, with the page number listed next each entry of course. So this makes it easier for the reader to find a subject or topic quickly. Like a table of contents, we need to mark the items in our document that are going to be included in the index and then we insert our index where we want it. And of course we update it each time we mark more entries.
Let's give this a try. So we're going to open up a document from the Office button, click Open and we'll go to recipe book 19, and actually 19B. Click that one, click Open and we'll scroll down and you can see, this is our recipe book, there's our table of contents, and like I said, I've marked a number of items in this document already to be included in an index. Let's go to the end of the document. We'll do a Control + End on the keyboard to get there quickly. And now we'll go up to references, click the References tab on the ribbon and over here we've got the Index group.
Let's insert our index. So the Index tab is selected here and you can see that the default under Print Preview here's showing us two columns, indent is the style, Run-in, you can see that looks a little bit different. I prefer indented. The number of columns we can increase if we want, using the arrows, or decrease. Kind of like levels in the table of contents. We can right-align page numbers. I kind of like that. And you can see we have the option of putting in leaders or lines, if we wanted to as a leader, or none at all.
I'm going to leave it at None at all and when we click OK, there it is, so you can see we've got two columns. Our first item, listed alphabetically, is chocolate and you can see all the pages were chocolate appears. Cupcake is next and you can see only appears on one page, same thing for lemon, tiramisu appears on two different pages. Now let's go add some things. I'm going to hold down Control and press the Home key to move back up to the top of my document, and I'm going scroll down past my table of contents and I'll go past the introduction as well, past the ratings, and we arrive over here.
I'm going to click right on page 6. Maybe raspberry would be a good one to mark for our index, so anything raspberry we know exactly what page to go to. So we select the text, we mark the entry. You can see raspberry is the entry. It is going to be taken from the current page, but down below, we can mark all of the occurrences of the word raspberry. So we do that and we hit Close. Now don't be alarmed if the formatting codes show up, and that's just an automatic reaction here from a selecting an item for our index.
We know how to close that right. Let's do still a little review. We click on the Office button, down to Word Options and if we don't want to view all over formatting codes, we click display and we deselect where it says Show all formatting marks and click OK. Alright, so we've added an item and if we scroll down to the bottom of our document, and we take a look at our index, it's not updated automatically. So, what we need to do is go up to Insert Index here. The index is exactly how we left it. Perfect.
All we really want to do is not insert another one, but update this one. So all we're going to do in this case is update our current index. When I click on it, you can see that happens, the whole thing gets selected. So now I can come up here and click Update Index, takes a second but look at that, raspberry is now added to the list. It appears on two pages and everything's kind of reformatted itself. So I'll deselect and that's the beginnings of our index. Of course we could do a little bit of a formatting, if we wanted to.
Click on the index, come in here to Insert Index and you can see we have some options here. From template gave us that pretty plain look but Fancy might be a good one. That's kind of nice to look. Then we click OK. Do we want to replace the selected index? You bet. You click OK and in comes the new one. I like that better. You see the headings for the various letters now. Once we get started adding more items, we're going to get more letters of the alphabet showing up. That's a little bit easier to read, I think it looks a lot better.
Now remember if you mark more entries, simply click in the index anywhere and click Update Index to get the new entries included. If you ever wish to start over and maybe change the look of your index, just insert it again and choose your different options like we just did. Here of course you'll be asked, if you want to replace that index and you just say yes and you're done.


text: My Party Best Kids Parties: The Very Hungry Caterpillar Carrie McBride Oct 24, 2012 Entertaining at Home My Party Home Share Pin Email Share Pin Email Name: Lennon (1) Location: U.S. My multi-talented hair stylists celebrated their son's 1st birthday a few weeks ago using "The Very Hungry Caterpillar" theme. It turned out so beautifully, I wanted to share pictures. My favorite thing about this party is that the decorations are so simple, yet make such a statement. This beautiful party shows how you can use a book or favorite character as your inspiration for decorations, favors, even food and not spend a fortune. Thanks Crystal! Readers, see more of Lennon's party on The Weekend Homemaker. (Images: Sarah Thornton) • MY PARTY ARCHIVE • SUBMIT YOUR CHILD'S PARTY Share Pin Email


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Quick and easy desserts
Recipes / Quick and easy desserts (211)
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Quick and Easy Stove Top Brownies, ingredients: , 1 box of brownies mix, 1 cup quick
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Easy Dump Cake: Angel Food Pineapple Cake
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Easy Dump Cake: Angel Food special category: Low calories, course: Desserts, type of
Apple Crisp – Microwave Quick!
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Quick!, main ingredient: apples, peeled, cored and sliced in wedges, , course: Desserts
Mary's Quick And Easy Dessert
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Mary's Quick And Easy Dessert, ingredients: 1 Sara Lee family size lb. cake, 1 (10
Quick And Easy Dessert
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Memorial Day Weekend Recipes For a Kick-Ass Cook Out: Includes Main Dishes, Grilled Cocktails, Veggies and Even Dessert!
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post) Grilled peaches and and pound cake or angel food cake- quick and easy dessert on the
Quick and Easy Gluten Free Guacamole
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and it dips well. Quick and Easy Guacamole 1 avocado, pitted, scooped from skin, and
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