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Telephone & Addresses
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Richard Rubino, Bristol, US, Preston St, Unit 1
View Richard Michael's social profiles and photos on Facebook, MySpace, and +40 Networks.
Richard Rubino, 76, Chandler, US, W Chandler Blvd, Apt 2314
View Richard Michael's social profiles and photos on Facebook, MySpace, and +40 Networks.
Richard Rubino, 41, Holbrook, US, Library Ln
View Richard Michael's social profiles and photos on Facebook, MySpace, and +40 Networks.
WhitePages: Michael Rubino in CT | Whitepages
24 matches for Michael Rubino in Connecticut. Find Michael Rubino's phone, address, etc. on Whitepages, the most trusted online directory."
Yellow Page contacts
Network Profiles
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LinkedIn: Richard Rubino | LinkedIn
View Richard Rubino's professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like Richard Rubino discover ...
LinkedIn: Michael Rubino | LinkedIn
View Michael Rubino's professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like Michael Rubino discover ...
(1 - 4 from 19
ArtSlant - Michael Rubino
ArtSlant profile for contemporary artist Michael Rubino. ArtSlant is the #1 Contemporary Art Network with comprehensive information on artists and events ...
Michael Rubino - K for the Appalachian State Mountaineers ...
See Michael Rubino bio, stats, news, notes, pictures, videos and more college football information on the Appalachian State Mountaineers K at FOX Sports.
Hookah Pens, Vaporizers and Your Teens | Patch
Pleasant Hill, CA - The Hookah or vaporizer pen is the new way for your teen to get high.
Michael Rubino's Men's Lacrosse Recruiting Profile
Evaluate Michael Rubino's men's lacrosse recruiting profile. Learn how this George W Hewlett High School student is connecting with coaches in NY and...
Management & Stakeholders
Michael Rubino | Stryker Corporation | Email @stryker.com
Michael Rubino is the Vice President - Finance of Stryker Corporation. Lead411's profile includes an email address, @stryker.com, linkedin, biography, etc
Business Profiles
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Michael Rubino | Elance
I am Michael Rubino,I have a background in Web/Graphic Design along with getting an Associates in Information Technology. Also i am comfortable with HTML, ...
Joseph Michael Rubino (Redwood City, CA, 94063 ... - Zocdoc
Book now with Joseph Michael Rubino of Redwood City, CA. Read patient reviews and ratings, and make an appointment online, instantly. View insurance ...
Richard Rubino, CENTURY 21 Real Estate Agent in Southington, CT
Richard Rubino is a Southington Real Estate agent from CENTURY 21 AllPoints Realty located in Southington, CT. Contact Richard Rubino today!
Mr. Richard Lawrence Rubino, Esq. Lawyer Profile on Martindale.com
Mr. Richard Lawrence Rubino, Esq. Profile by Martindale-Hubbell. Find Mr. Richard Lawrence Rubino, Esq. contact information, experience and credentials, peer...
Private Homepages
About | Rubino & Liang
Our firm is equipped to deal with the challenges retirees face. We want to make sure that your money & real estate are protected.
Castelli Real Estate Services
Contact Information: Richard Rubino. Phone: (954) 563-9889. Fax: (954) 563-9883. Cell: (631) 827-3988. Castelli Real Estate Services. 2227 Wilton Drive
Michael Rubino | Callaway Architecture
Director of Production / Construction Administrative. Mike has over 30 years of experience in the architectural profession. He brings to Callaway as a Director of ...
Staff of the Office of Aquaculture :: Office of Aquaculture
Headquarters Staff Michael Rubino. Dr. Michael Rubino is the Director of the Aquaculture Office in Silver Spring, Maryland. He joined NOAA in late 2004 to lead …
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classmates: Richard Rubino
Haverhill High School, Haverhill, MA, 1946-1950
classmates: Richard Rubino
Pelham Memorial High School, Pelham, NY, 1977-1981
classmates: Richard Rubino
Brockport High School, Brockport, NY, 1970-1974
classmates: Richard Rubino
Hill High School, Lansing, MI, 1973-1977
Celebrities & Politicians
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Michael Rubino Discography at Discogs
Complete your Michael Rubino record collection. Discover Michael Rubino's full discography. Shop new and used Vinyl and CDs.
IMDB Filmography: Michael Rubino - IMDb
Michael Rubino, Music Department: Biography
Bad news
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legacy.com: Richard F. Rubino
Richard F Rubino, 70 years old, died suddenly at Halifax Hospital in Daytona Beach on May 20, 2008. Dick was born in New Haven, Conn., son of Larry and Viola Rubino. He most
legacy.com: Michael Rubino
MICHAEL RUBINO Michael Rubino, 67, a mechanic, died Dec. 2, 2009, in Las Vegas. Visitation 1-4 p.m. and 6-9 p.m. Sunday, Dec. 6, at Kraft-Sussman Funeral Services. Service at 10
legacy.com: Michael Rubino
Michael Rubino 1922-2009 SPRINGFIELD- Michael Rubino 86, died July 10, 2009 in Baystate Medical Center. Michael was born in Hartford on August 8, 1922 son of the late, Anthony
findagrave: Rubino, Dr Michael A
06/1/1933 - 12/15/1994, Whittier (Los Angeles County, California)
Richard Rubino - Genealogy
View Richard Rubino's genealogy family tree on Geni, with over 150 million profiles of ancestors and living relatives.
Michael Rubino (deceased) - Genealogy
Genealogy for Michael Rubino (deceased) family tree on Geni, with over 140 million profiles of ancestors and living relatives.
Richard Rubino in the 1940 Census | Ancestry.com
View Richard Rubino's 1940 US census record to find family members, occupation details & more. Access is free so discover Richard's story today.
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Richard Rubino - Real Estate Agent - Century 21 AllPoints Rlty
Richard Rubino - real estate agent - Century 21 AllPoints Rlty. Find more information about Richard Rubino on The Real Estate Book.
Richard Rubino's Real Estate Listings - Homes for Sale by Richard...
View all of the homes for sale by CENTURY 21 real estate agent Richard Rubino. Real estate agent Richard Rubino can answer any questions about buying or...
Richard Rubino | LoopNet
Richard Rubino - Century 21 Lil 1. View Richard Rubino's professional profile and available commercial real estate listings on LoopNet.com.
Richard Rubino - Southington, CT Homes For Sale | HomeFinder.com
Connect with Richard Rubino on HomeFinder.com. See homes for sale, property photos, neighborhood details, and virtual tours.
Books & Literature
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Michael Rubino | Barnes & Noble
How We Came to Be, Author: Michael Rubino ... by John Mariano Michael Rubino ... Title: With Liberty and Justice for None, Author: Robert Michael Rubino ...
Plunkett's Nanotechnology & Mems Industry Almanac 2008
Michael Rubino, VP-Finance Evan Sanders, VP-Global Sales Robert Johnson, VP/Gen. Mgr.-Energy Solutions Group Desh Deshpande, Chmn. Tao Zheng, ...
Small Property Versus Big Government: Social Origins of ...
Michael Rubino was a regular guy. A forty-year-old beer truck driver, he was outgoing and unpretentious. Through his deliveries and by once owning a gasoline ...
Growing Up Jewish in the 20th Century: 1910-2000: Mom's ...
28 Jul 1921, Rolla Missouri I I I Woody Michael RUBINO* I I I b. 30 Jan 1949, Lincoln, Nebraska I I I edu. B.S., U.S. Naval Academy, 1971; MS. Computer Science ...
Michael Rubino Concert Setlists | setlist.fm
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Related Documents
Annual Report of the Society - February 2014
Sergeant, Capt. Wells Militia. Richard Michael Rubino. OEC. Benjamin Dennis. Private, Massachusetts 9th & 21st Reg't. Steven Francis Sawyer.
Plaintiffs Michael Rubino and Gerald Weimer ("the officers") appeal from an order of the District Court granting the defendants' motion to ...
Guy & Michael Rubino – Rain - P30 Hospitality Products
04.01.2012 Rain 19 Mercer Street Toronto Ontario 416 599 RAIN. With heavy influences of Northern and South East Asian flavors and techniques Guy continues with his innovative and sometimes over the top style placing exceptional ...
Video & Audio
Michael Rubino - Hudl
Check out Michael Rubino's Football highlights on Hudl. Michael Rubino goes to Middle Creek High School in Apex, NC. Michael Rubino plays for the team ...
Richard Rubino - YouTube
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Michael Rubino Demo Reel on Vimeo
Here is a demo reel for Mike Rubino. He has appeared on Devious Maids, Walt Before Mickey and many more upcoming projects! Stay tuned.
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Club thieves' phone tapped, court told - Canberra Times
Police say Michael John Robertson and Richard Michael Rubino were taped discussing burglaries, ''doing a recce'' for a break-in at the ...
Consultant busted for stealing dough from Manhattan eateries
Richard Michael Rubino, 26, pleaded guilty in September to one theft and three burglaries, which occurred between November 2010 and ...
Michael Rubino - Devious Maids Wiki - Wikia
Michael Rubino is one of the episodic actors of Devious Maids, portraying the role of a cop. Not...
Sledgehammer robber fails to shave time off sentence
Richard Michael Rubino, then 23 or 24, was accompanied by two others when he broke into the Weston Club three times between November ...
Reports & Statements
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Twitter Posts: Canberra Times on Twitter: "Richard Michael Rubino looked ...
Canberra Times Verified account @canberratimes 14 Aug 2013. Richard Michael Rubino looked set to escape drug convictions. Then his ...
Super Simple and Super Useful: Michael Rubino Shows ...
North Star Academy's Michael Rubino demonstrates Radar and Be Seen Looking.
Wikipedia: Guy Rubino - Wikipedia, the free encyclopedia
Guy and Michael Rubino started talks with Food Network Canada in 2001 to make a show about the behind-the-scenes in a high-end restaurant. In 2003, Made to Order aired on
Richard Rubino Condolences | St. Louis Post-Dispatch
Guest Book for Richard Rubino of Ballwin, MO. Share your condolences, send flowers, find funeral home information. Guestbook provided by ...
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Eliteprospects.com - Michael Rubino
Eliteprospects.com player profile of Michael Rubino 1990-07-24 Canada.
Michael Rubino's - CrowdRise
THE MANHATTAN CHILDRENS CENTER INC wrote - The Manhattan Childrens Center was established with the belief that all children with autism and related ...
Megan Foley and Michael Rubino's Wedding Website
Welcome to Megan Foley and Michael Rubino's Wedding Website! View photos, directions, registry details and more at The Knot.
R v RICHARD MICHAEL RUBINO - [2012] ACTSC 157 - Jade
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R v Richard Michael Rubino - JustisOne
1. In November 2010 and February 2011, the Weston Club in Canberra was, on three occasions, broken into and cash changing machines and poker machines ...
Michael Rubino
Home page · Originals · Portraits · Book · Bio · Contact · Michael Rubino · Home page · Originals · Portraits · Book · Bio · Contact. Originals. Portraits. Book.
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Michael Rubino is the CFO of Digital Lumens, Inc., and a survivor of cardiac arrest.
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Michael Rubino is a Full-stack Developer, Mobile Developer, and Game Developer specializing in Unity, C#, Objective C, Ruby on Rails, and Java. Follow ...
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Michael Rubino, Director of the Office of Aquaculture at the National Oceanic and Atmospheric Administration's Fisheries Service. The United ...
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Erie's cold winter delays spring allergy season
Northwestern Pennsylvania's cold and snowy winter did come with a silver lining.
It delayed spring allergy season.
"I've seen people suffer from spring allergies in mid-March before, and I haven't seen that this year," said Philip Gallagher, M.D., an allergist with Allergy & Asthma Associates of Northwestern Pennsylvania. "I haven't even ventured on my roof yet to take pollen samples."
Record-breaking cold temperatures have delayed the budding of trees, which produces most of the pollen that triggers spring allergies.
Spring allergy season won't come until morning temperatures rise above 40 degrees, prompting trees to pollinate, Gallagher said.
"The other issue is whether the really cold weather damaged the trees," he said.
If few trees were damaged, the area could still see a moderate-to-severe spring allergy season, just later than normal. A typical spring allergy season followed the cold winter of 1993-94, according to Gallagher's records.
The severity of spring allergy season will depend on the type of weather we have over the next few months.
Dry weather is perfect for high pollen counts because the pollen stays airborne and is easily inhaled by allergy sufferers, Gallagher said.
"It doesn't have to get much warmer, but if we see a lot of rain, it just washes the pollen away," Gallagher said.
Tom Toale, owner and pharmacist at Frontier Pharmacy, has already seen some allergy sufferers this month despite the cold temperatures.
He has a new weapon at his disposal this year: an over-the-counter steroidal nasal spray.
"It's the first year we can offer Nasacort over the counter," Toale said. "It's the same strength as it was by prescription."
Steroidal nasal sprays are good for sufferers who don't get enough relief from antihistamines like Claritin and Allegra.
"It really helps with the persistent nasal stuffiness some people have," Gallagher said. "You can even take it in combination with the over-the-counter antihistamine."
If allergy sufferers still can't find relief, Gallagher recommends seeing a primary care physician, who will likely refer them to Gallagher's office.
Spring allergy season usually lasts until late May or early June. It is followed by a summer allergy season spurred by grass pollen, and a fall allergy season caused by ragweed pollen.
DAVID BRUCE can be reached at 870-1736 or by e-mail. Follow him on Twitter at twitter.com/ETNbruce.

subset: commoncrawl


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Christmas in October
It's just the beginning of October, but mail to our sponsored children takes time to arrive, which makes now the time to be thinking about the Christmas letter you send to your child.Continue Reading ›
"My World Turned Upside Down So I Could Live Right-side Up."
Carolyn's sponsorship story started almost 20 years ago after hearing a ministry presentation. The name of her first sponsored child was Danny and he was from Honduras.Continue Reading ›
"You (and Your Letters) Made Me a Good Child"
If you were forced to quickly leave your home of 17 years, what items would you grab first? For Maribel, she rescued the items most valuable to her — her sponsor's letters.
Join the Letter Writing Club on Pinterest
Pinterest is a wonderful place for us to connect as sponsors and share letter writing ideas. Building on the online letter writing event that Compassion has on the second Friday of every month, we've created a new Pinterest board for letter writing and you are welcome to join us as a contributor.
Remembering Abigail
Abigail lives in Ghana, is the youngest of six siblings, and her father died when she was three years old. Abigail taught her sponsor to enjoy letters from preschool and early elementary children.
The Power of a Letter
Esther and Marcos work at the Compassion office in Lima, Peru. They are both Compassion Alumni. Angie has just recently been sponsored. The three of them taught Pastor Ken Burkey about the power of a letter.
10 More Reasons to Write Your Child
For many of us, the letters we exchange are the closest we'll ever come to our sponsored children. And even though we may understand the impact of our letters, it is still difficult to actually make the time to write a letter. That's just reality.
Top 10 Reasons to Write Your Sponsored Child
It might seem like just words on a page. But something in your letter will change your child's thinking, draw him closer to God, encourage her to dream.
Change Someone's Everything
October was going to be a normal month with planned dinner dates and errand running and church on Sundays…but one evening, one thing changed, and it changed everything. That one thing was a death.
The Power in a Name
While the significance of a name may not carry as much weight as it previously did in Western culture, one's name is still the most distinguishing characteristic an individual in a developing country clings to.
Sponsored Children Need Us to Be Jesus
Sponsored children need to know that we love them and pray for them; they need our encouragement to do well in school and at the center, and to remember that Jesus loves them very much.


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"On another note," Clabo said in the middle of an answer, "we have a game Monday night against Tampa. That's a pretty big deal. We're excited. I thought we had a good practice. I though we had good energy. I'm excited to see how we're going to go out and perform."
Yes, the Miami Dolphins do have a game to play Monday night, even though that's almost been forgotten this week amid the back-and-forth, accusations and questions relating to the events that led to Martin leaving and Incognito being suspended by the team.
While the media inquiries continued in full force Saturday, the players in the locker room said they have been and remain focused on what they're paid to do — trying to win football games.
"We're ready to play again," cornerback Nolan Carroll said. "I'm tired of all this stuff that's going on. I'm tired of hearing all the questions about something that, honestly, I have no control over. I'm just ready to play on Monday."
The game against Tampa Bay will come 11 days after Miami's last outing, an overtime battle that ended with Cameron Wake winning the game for the Dolphins with a sack of quarterback Andy Dalton in the end zone.
The victory put the Dolphins at 4-4, and they're currently tied for sixth in the AFC in the loss column.
But the Cincinnati game, the start of the second half of the season and the team's playoff aspirations have barely registered a blip on the radar screen in the last week or so.
"We didn't hear anything about our win last week, we didn't hear anything about winning on a safety, none of that," cornerback Brent Grimes said. "We just (went) right into this stuff. Hopefully after Monday night, if we play well, we go out there and play well and put some good stuff out there, maybe that'll push this to the backburner a little bit."
In Tampa Bay, the Dolphins will face a team with issues of their own, namely an 0-8 record, the departure of former starting quarterback Josh Freeman and reports of displeasure with Coach Greg Schiano.
The Dolphins, meanwhile, will feel a tangible impact from the absence of both Martin and Incognito, two of their starters up front. Veteran Tyson Clabo again will replace Martin at right tackle, as he did against Cincinnati, while the left guard spot will be manned by Nate Garner, who stepped into the lineup after Incognito sustained a neck injury in the first quarter of the Halloween night game.
Not surprisingly, though, Dolphins players were asked about the Martin/Incognito situation being a distraction that could hurt the team on the field.
"Something like this can really just bring a team together and I think that's what happened because we've had some really good practices here," defensive tackle Jared Odrick said. "When you have incidents like this, it's time to pull together and refocus and come together for one common goal and that's what I think we did this week."
Said Clabo: "We see it a distraction that we're not going to let distract us. We're going to stay focused on football.
"The pressure that all this has created from the media standpoint can really cause some problems. But as far as the guys in this locker room, we all pretty see this thing through the same set of eyes. We're just ready to go and try to change the narrative here and get back to football and get back to people talking about we've got a pretty good football team here."
For more Dolphins news, check out http://mia.scout.com/4/1.html.


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Home > News > NANOSAFE project publishes study on the risks of nanoparticles
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With a different Superman around, how will the Trinity get along?
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Author Affiliations: Pediatric Multiple Sclerosis and Demyelinating Disorders Center of the Jacobs Neurological Institute, Women and Children's Hospital of Buffalo (Drs Yeh, Ramanathan, and Weinstock-Guttman) and Departments of Neurology (Drs Yeh, Ramanathan, and Weinstock-Guttman) and Pharmaceutical Sciences (Dr Ramanathan), State University of New York, Buffalo, and National Pediatric MS Center, Department of Neurology, State University of New York, Stony Brook (Drs Krupp and Belman); Regional Pediatric Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco (Drs Waubant and Chabas); Center for Pediatric Onset Demyelinating Disorders, University of Alabama at Birmingham (Drs Ness and Rinker); Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, Boston (Drs Chitnis and Gorman); Mazza Foundation Neuromuscular Program, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (Dr Kuntz); and Pediatric Multiple Sclerosis Center, Mayo Clinic, Rochester, Minnesota (Dr Rodriguez).
Pediatric-onset multiple sclerosis (MS) composes approximately 3% to 5% of cases of MS in North America.1- 4 Six disease-modifying therapies (DMTs) have been approved for treatment of relapsing-remitting MS in the adult population. The 4 first-line DMTs are glatiramer acetate, intramuscular (IM) interferon beta-1a, subcutaneous (SC) interferon beta-1a, and SC interferon beta-1b; the 2 second-line DMTs are mitoxantrone hydrochloride and natalizumab. In addition, therapies such as rituximab, daclizumab, and cyclophosphamide have been evaluated in phase 2 trials in adults with breakthrough disease, as have add-on therapies such as monthly steroids and intravenous immunoglobulin.5- 10
Currently available first-line DMTs for MS are reported to decrease the relapse rate by approximately 30% in adults with MS,11 although this number may be greater in present-day MS populations.12 Although definitions of partial therapeutic effectiveness and breakthrough disease may vary, in general these phrases imply clinical (ie, presence of recurrent relapses or progression of disability) and/or radiological (new or enlarging magnetic resonance imaging [MRI] lesions) disease activity despite adherence to an appropriate therapeutic regimen. The biological mechanisms behind breakthrough disease on therapy have not been elucidated but may be due to genetic, immunological, or environmental disease heterogeneity.
In the pediatric MS population, multiple retrospective studies evaluating the safety and tolerability of first-line DMTs, including interferon beta and glatiramer acetate, suggest that they are well tolerated.13- 19 Recent retrospective case series suggest that many children in this population may require therapeutic intervention beyond currently accepted first-line DMTs.20- 22 However, there are no data on the frequency of breakthrough disease and its management in this population.
Our aim was to describe the frequency and management of disease refractory to first-line therapies in 258 pediatric patients with MS seen at 6 American Pediatric MS Centers of Excellence.
This was a multicenter, retrospective, longitudinal, open-label study of 258 patients with pediatric-onset MS. These patients were seen at the Pediatric MS Centers of Excellence, a 6-center network supported by the National MS Society with centers located in San Francisco, California (University of California, San Francisco), Rochester, Minnesota (Mayo Clinic), Birmingham, Alabama (University of Alabama at Birmingham), Buffalo, New York (State University of New York, Buffalo), Stony Brook, New York (State University of New York, Stony Brook), and Boston, Massachusetts (Harvard University, Massachusetts General Hospital, and Partners HealthCare). The network prospectively collects data regarding children with demyelinating disorders, including clinically isolated syndromes, MS, acute disseminated encephalomyelitis, and neuromyelitis optica. Approval by the institutional review board of each institution for data collection and sharing was granted.
Children younger than 18 years with a diagnosis of pediatric relapsing-remitting MS23 who had been receiving first-line treatment with a DMT (IM or SC interferon beta-1a, SC interferon beta-1b, or glatiramer acetate) for a minimum of 6 months were included in the analysis. All patients who were diagnosed as having MS at each of the sites were offered therapy; the only children who did not receive therapy were those who went against these recommendations. Data from all children presenting between August 1997 and August 2009 who were treated were analyzed. Age at disease onset, clinical presentation, sex, ethnicity/race, time of initiation of DMT, time to change in therapy, and reason for change in therapy were recorded using a standardized data collection template. The distribution of patients according to center was as follows: 27 patients at the University of California, San Francisco; 58 at the University of Alabama at Birmingham; 90 at the State University of New York, Stony Brook; 25 at Mayo Clinic; 26 at Harvard University, Massachusetts General Hospital, and Partners HealthCare; and 32 at the State University of New York, Buffalo. Children whose diagnosis of MS could not be confirmed were excluded, as were patients with a diagnosis of MS who were not treated.
Pediatric-onset MS was diagnosed following operational definitions of pediatric demyelinating disorders published by the International Pediatric MS Study Group.23According to these definitions, pediatric MS may be diagnosed after 2 clinical episodes of central nervous system demyelination that are separated by at least 30 days. No lower age limit is specified.
Refractory disease status was defined by individual health care practitioners and included the presence of clinical activity (MS relapses) and/or MRI activity (new lesions on T2-weighted imaging or gadolinium-enhancing lesions on repeated MRI scans of the brain or spine).
Race (American Indian or Native Alaskan, Asian, black or African American, Native Hawaiian or other Pacific Islander, white, and mixed) and ethnicity (Hispanic and non-Hispanic) were defined following National Institutes of Health guidelines.24
In a small number of cases, children were treated with a lower dose of medication than that recommended for the adult population. When dose escalation owing to breakthrough disease occurred in that small subgroup of patients, the increased dose was not considered a change. Special note has been made of these cases as appropriate. Clinicians were asked to identify whether each medication change was owing to breakthrough disease or other issues, such as adverse effects or compliance issues. As only the primary reason for a change was elucidated from investigators, we did not note children who had a medication change owing to a combination of breakthrough disease and concomitant adverse effects.
We used SPSS version 15.0 statistical software (SPSS Inc, Chicago, Illinois) for all statistical analyses. Because of the multiple testing involved in the analysis of clinical data, we used a conservative α = .01 to assess statistical significance. A statistical trend was assumed if P ≤ .05.
One-way analysis of variance (ANOVA) followed by post hoc independent sample t tests were used for 2-group comparisons to test for differences in means of continuous demographic variables such as age, age at onset, and disease duration. The χ2 test was used for analysis of count variables for categorical data, and the Fisher exact test was used when appropriate. Logistic regression was used to analyze the use of second-line therapies (including chemotherapies, natalizumab, and combination therapies) as the dependent variable with age at symptom onset, sex, and Hispanic vs non-Hispanic ethnicity as predictor variables.
The clinical and demographic features of the 258 children and adolescents are summarized in Table 1. During the observation period (mean [SD], 3.9 [2.8] years), 144 children (55.8%) were treated with only 1 therapy, 65 (25.2%) changed therapies once, 29 (11.2%) changed therapies 2 times, 10 (3.9%) changed therapies 3 times, and 10 (3.9%) children changed therapies 4 or more times (Figure, A). Therapy was limited to interferon beta and glatiramer acetate in 203 children (78.7%), whereas other treatments such as broad-spectrum chemotherapies (eg, cyclophosphamide, mitoxantrone), natalizumab, monthly pulse corticosteroids, and daclizumab were used during the observation period for 55 children (21.3%) for disease management.
Therapies required and reasons for changing therapy. A, Distribution of the number of therapies required. For children using 1 therapy, 52.3% continued to receive the first therapy prescribed for the observation period and did not require changes in therapy (dark gray portion of bar), whereas 3.5% discontinued therapy (light gray portion of bar). B, Reasons for changing therapy. C, Distribution of the types of therapies required at each stage of therapy. IM indicates intramuscular; SC, subcutaneous.
There were no statistically significant differences between centers in numbers of therapies used, sex distribution, age at onset of symptoms, interval between start to stop of first agent or duration of disease, and Expanded Disability Status Scale score at initiation of therapy. There were modest differences in length of follow-up. This was greater at the State University of New York, Stony Brook, compared with the other centers. There were differences between center in the proportions of African American children (State University of New York, Stony Brook [17.8%], University of Alabama at Birmingham [46.6%], and Harvard University, Massachusetts General Hospital, and Partners HealthCare [19.2%] vs State University of New York, Buffalo [3.1%], University of California, San Francisco [7.4%], and Mayo Clinic [12.0%]) and Hispanic ethnicity (State University of New York, Stony Brook [24.4%], University of California, San Francisco [37.0%], and Harvard University, Massachusetts General Hospital, and Partners HealthCare [23.1%] vs State University of New York, Buffalo [0.0%], University of Alabama at Birmingham [1.7%], and Mayo Clinic [4.0%]) based on population demographic characteristics in the vicinity of the pediatric MS centers.
Overall, baseline disability scores were low. The mean Expanded Disability Status Scale score at the first clinical visit was 2.1 (median, 2.0; interquartile range, 1.0-3.5). The mean Expanded Disability Status Scale score at the last visit was 1.7 (median, 1.5; interquartile range, 1.0-2.0). Using regression analysis, which corrected for sex, age at onset, and length of follow-up, change in Expanded Disability Status Scale score was significantly associated with the number of therapies used (P = .004).
The mean (SD) interval between disease onset and initiation of the first DMT was 17.1 (20.4) months (range, 0.0-96.3 months). Interferon beta (200 of 258 patients [77.5%]) and glatiramer acetate (53 of 258 patients [20.5%]) were the most frequently used first therapies (Figure, C). Five patients (1.9%) received pulse cyclophosphamide (n = 4) or azathioprine (n = 1) as a first therapy (Table 2) owing to very active acute disease. These patients were later prescribed first-line DMTs.
The majority of children (n = 135 [52.3%]) continued to receive the first therapy prescribed for the observation period and did not require changes in therapy (Table 3 and Figure, A). Nine children (3.5%) discontinued therapy. Medication was changed in 114 children (44.2%) on account of poor tolerance or noncompliance (n = 42 [16.3%]) or refractory disease (n = 72 [27.9%]). Overall, 11 children changed therapies owing to elevated liver function enzyme levels. All were receiving interferon beta products (IM interferon beta-1a, n = 2; SC interferon beta-1a, n = 8; SC interferon beta-1b, n = 1). Medication changes after the first therapy occurred secondary to MRI changes alone in 10.7%, clinical relapses in 61.3%, and both MRI changes and clinical relapses in 28.0%; changes to a third therapy were owing to MRI changes alone in 6.0%, clinical relapses in 54.5%, and both MRI changes and clinical relapses in 39.3%.
The mean (SD) time to change from first to second therapy for the group reporting poor tolerance or noncompliance was 1.1 (1.2) years. The mean (SD) time to change of first therapy in the refractory group was 1.3 (1.3) years. There was no evidence for differences in age at onset (1-way ANOVA, P = .33), length of follow-up from the first event to the last follow-up (1-way ANOVA, P = .38), or duration of treatment with the first agent (1-way ANOVA, P = .46) between the groups with no treatment change, poor tolerance or noncompliance, and refractory disease.
There was no evidence for sex differences in the frequency of changes owing to poor tolerance or noncompliance (11 of 81 boys [13.6% of boys] vs 40 of 177 girls [22.6% of girls]) or in the frequency of changes owing to refractory disease (23 of 81 boys [28.4% of boys] vs 49 of 177 girls [27.7% of girls]).
Table 4 provides details on age, ethnicity, and race. In general, children younger than 10 years compared with those aged 10 years or older were less likely to change therapy owing to noncompliance or poor medication tolerability (7.3% vs 21.4%, respectively). The proportion of children with refractory disease requiring a change in therapy was similar in the 2 groups (24.4% vs 28.1%, respectively). The time between the first demyelinating episode and initiation of the first DMT was longer in children younger than 10 years.
Despite similar disease duration, age at onset, and time to the first medication change, Hispanic children were significantly more likely than non-Hispanic children to require medication changes. Medication changes owing to poor tolerance and noncompliance were higher in Hispanic children than in non-Hispanic children. There was no evidence for differences between African American and non–African American children in the frequency of medication changes owing to poor tolerance or noncompliance or to refractory disease (Table 4).
Of the 42 children who changed medications owing to poor tolerability or noncompliance, 4 (9.5%) went on to experience refractory disease while receiving the second agent tried and 13 (31.0%) changed therapies owing to poor tolerability or noncompliance again. The majority of children (42 of 72 children [58.3%]) who experienced refractory disease while receiving the first agent responded to treatment with the second agent.
Table 3 provides information on the interferon beta therapies used as the first treatment. Four of the children requiring a medication change while receiving IM interferon beta-1a were initially prescribed a low dose (7.5 μg). Three experienced refractory disease requiring dose escalation, and 1 required change to SC interferon beta-1a after dose escalation owing to refractory disease. The frequency of poor tolerability or noncompliance was similar across all 3 interferon beta products. Duration of therapy was similar in all groups. There was no evidence for differences in the time to change to second therapies among the different first therapies (ANOVA, P = .79) (Table 3).
We also compared the frequency of changes owing to refractory disease in Hispanic patients with that in non-Hispanic patients for each of the interferon beta products used as a first therapy. The frequency of changes owing to refractory disease in Hispanic patients treated with IM interferon beta-1a was higher than that in non-Hispanic patients. The frequencies of refractory disease in Hispanic and non-Hispanic patients treated with SC interferon beta-1a were similar (χ2 = 0.9; P = .64). Hispanic patients treated with SC interferon beta-1b were more likely than non-Hispanic patients to have poor tolerance or noncompliance; the frequency of refractory disease in Hispanic patients treated with SC interferon beta-1b was not significantly different from that in non-Hispanic patients treated with SC interferon beta-1b. Duration of therapy was similar in the groups (Table 4).
Nineteen children were tested for anti–interferon beta neutralizing antibodies. Two of the children (10.5%) had positive results (one was receiving SC interferon beta-1a and the other was receiving SC interferon beta-1b). Of those with negative results, 9 were receiving IM interferon beta-1a, 7 were receiving SC interferon beta-1a, and 1 was receiving interferon beta-1b.
Of the 53 children (20.5%) who were prescribed glatiramer acetate as a first agent, 8 (15.1%) changed medication owing to poor tolerability or noncompliance and 11 (20.8%) changed medication owing to refractory disease. Children receiving glatiramer acetate compared with those receiving any interferon beta products as group showed no differences in the overall frequencies of changes owing to poor medication tolerability or breakthrough disease (χ2 = 3.6; P = .17) (Figure).
Pairwise comparisons of therapy changes owing to refractory disease while receiving glatiramer acetate vs individual interferon beta products showed a trend toward a lower frequency of medication changes owing to breakthrough disease with glatiramer acetate compared with SC interferon beta-1b (20.8% vs 43.8%, respectively; χ2 = 8.8; P = .01). The frequency of medication changes for breakthrough disease with glatiramer acetate was similar to that with SC interferon beta-1a (20.8% vs 15.8%, respectively; χ2 = 1.0; P = .60) and to that with IM interferon beta-1a (20.8% vs 35.9%, respectively; χ2 = 5.4; P = .07). Hispanic children were more likely to change therapy owing to refractory disease while receiving glatiramer acetate (5 of 9 children [55.6%]) than non-Hispanic children (6 of 44 children [13.6%]) (χ2 = 13.5; P = .001).
The second therapy to which children were changed consisted of interferon beta or glatiramer acetate in 62.5% of children experiencing refractory disease. Generally, the frequency of the low-dose IM interferon beta-1a regimen declined and the frequency of other therapies increased (Figure, C). Other therapies including broad-spectrum chemotherapy (cyclophosphamide, mitoxantrone [10 of 72 children]), natalizumab (7 of 72 children), or others (intravenous immunoglobulin, daclizumab, azathioprine, mycophenolate mofetil [10 of 72 children]) were used in more than one-third of patients experiencing refractory disease (27 of 72 children [37.5%]). Combination therapies were used in 22 instances; most of these were the addition of intravenous immunoglobulin or steroids to first-line DMTs (intravenous immunoglobulin and first-line DMT, 9 of 22 children; monthly steroids and first-line DMT, 3 of 22 children), but combination therapies also included chemotherapy plus first-line DMTs (9 of 22 children) and glatiramer acetate plus interferon beta-1a (1 of 22 children).
Seven children were tested for natalizumab-neutralizing antibodies. Two patients receiving natalizumab developed breakthrough disease and were found to have antinatalizumab antibodies. One patient developed a hypersensitive reaction after reintroduction of natalizumab and was found to have developed neutralizing antibodies.
The use of other therapies was analyzed as a dependent variable in logistic regression with age at symptom onset, sex, and Hispanic ethnicity as predictor variables. The overall model for use of other therapies was strongly associated with Hispanic ethnicity (B [SE], 1.7 [0.38]; P < .001). In contrast, age at symptom onset (P = .19) and sex (P = .98) were not significant predictors of breakthrough disease.
It is remarkable that approximately half of the children included in this study had their therapy changed to a second agent owing to refractory disease (27.9%) or poor tolerability of a first-line DMT (16.3%) or quit therapy (3.5%). These figures stand in contrast to some adult MS studies, where, depending on the criteria used, up to 49% of patients may be considered nonresponders to first-line therapy,25 although other more recent data from adult MS studies suggest a similar rate of changing therapy owing to refractory disease (30%).26 It is unclear whether the different definitions of breakthrough disease used in this study and adult studies may explain these different outcomes or whether there are underlying biological processes resulting in a differential rate of refractory disease.
Although African American patients with adult-onset MS have more aggressive disease27,28 and possibly poorer response to interferon beta than white patients,29 we did not confirm a higher rate of poor response in pediatric patients with MS who were African American compared with white patients. This may be owing in part to the relatively small sample size, although the proportion of African American children in our cohort (20.9%) is greater than that in adult MS cohorts. Although another explanation for this might be that poor outcomes in Hispanic white children worsened overall outcomes in the group of white children, analysis comparing non-Hispanic, non–African American children with African American children showed no significant differences between the 2 groups in the rate of refractory disease requiring medication change (22.9% in non–African American, non-Hispanic children vs 26.9% in African American children). Earlier intervention after disease onset, differences in time receiving DMT, and fewer comorbidities than those encountered in the adult population of African American patients with MS may also contribute to this difference.
Children whose families self-categorized as Hispanic (n = 40) were more likely to have refractory disease requiring a change in first-line therapy and to need second-line therapies than non-Hispanic children. It is unclear whether referral bias may in part explain this finding as we could not adjust our analysis for pre-DMT relapse rate or socioeconomic status. Complex socioeconomic, psychological, and biological factors outside the scope of this study may have influenced this outcome.
Even in adult MS, a widely accepted consensus definition of treatment failure, a phrase often interchangeable with breakthrough disease, does not exist. Some have suggested that the presence of more than 1 relapse per year, no decrease in the relapse rate, incomplete recovery from relapses or accumulation of disability, new brainstem or spinal cord lesions on MRI, or worsening of motor or cognitive status may support the need for a therapy change. In general, these criteria are reserved for those who have been receiving therapy for at least 6 months.30
The lack of a consensus definition of breakthrough disease in adults, the relative rarity of pediatric MS, and the unknown magnitude of effect of DMT in the pediatric population have prevented the development of both a consensus definition for breakthrough disease and recommended therapeutic management strategies in pediatric MS. Most health care practitioners participating in this study made changes after patients experienced more than 1 clinical relapse or MRI change per year.
Second-line agents and combination therapies were used with relative frequency for severe or refractory disease in our patients. This suggests that pediatric MS may not be a benign disease. The long-term safety of these second-line therapies or combination strategies in children is unknown. Vigilance should be maintained while using these agents in this population.
Our study has several limitations. First, its retrospective nature limits the availability of information such as pre-DMT relapse rate and socioeconomic status, which would help to adjust some of our analyses and verify the robustness of the finding of a higher rate of breakthrough disease in Hispanic children. Second, the relapse rate while the patients are receiving treatment is not available, thus limiting our ability to better describe the treatment benefit in our cohort. Third, our ability to comment on the benign or aggressive nature of pediatric MS is limited by the potential bias that children not receiving therapy were not included in the analysis. However, we emphasize that all children seen at the centers who were diagnosed as having MS received the recommendation to initiate therapy, and only a small number (3.5%) of children discontinued therapy altogether and were therefore untreated. Finally, as this was a retrospective analysis, initial treatment choices may have been influenced by individual practice patterns and perceived disease severity, thus potentially skewing the results.
Further studies evaluating the short- and long-term safety and efficacy of these agents are needed, as are studies examining the socioeconomic, psychological, and biological mechanisms behind differences in breakthrough disease in pediatric-onset MS. Finally, collaborative work clarifying the definition of breakthrough disease and identifying optimal treatment strategies in pediatric MS is necessary to improve patient care in the future.
Correspondence: E. Ann Yeh, MD, Women and Children's Hospital of Buffalo, Division of Child Neurology, Pediatric MS Center of Excellence of the JNI, 219 Bryant St, Buffalo, NY 14222 (firstname.lastname@example.com).
Accepted for Publication: September 21, 2010.
Published Online: December 13, 2010. doi:10.1001/archneurol.2010.325
Author Contributions: Dr Yeh had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Yeh, Waubant, Kuntz, Belman, Chabas, Rodriguez, and Weinstock-Guttman. Acquisition of data: Yeh, Waubant, Krupp, Ness, Chitnis, Kuntz, Belman, Chabas, Gorman, Rinker, and Weinstock-Guttman. Analysis and interpretation of data: Yeh, Waubant, Ness, Kuntz, Ramanathan, Belman, Rodriguez, and Rinker. Drafting of the manuscript: Yeh, Waubant, Chitnis, Kuntz, Ramanathan, Belman, Chabas, and Rodriguez. Critical revision of the manuscript for important intellectual content: Yeh, Waubant, Krupp, Ness, Chitnis, Kuntz, Ramanathan, Gorman, Rinker, and Weinstock-Guttman. Statistical analysis: Yeh and Ramanathan. Obtained funding: Yeh, Ness, Chitnis, and Chabas. Administrative, technical, and material support: Waubant and Rodriguez. Study supervision: Waubant, Krupp, Rodriguez, and Weinstock-Guttman.
National Network of Pediatric MS Centers of Excellence Members: E. Ann Yeh, MD; Emmanuelle Waubant, MD, PhD; Lauren B. Krupp, MD; Jayne Ness, MD, PhD; Tanuja Chitnis, MD; Nancy Kuntz, MD; Murali Ramanathan, PhD; Anita Belman, MD; Dorothee Chabas, MD, PhD; Mark P. Gorman, MD; Moses Rodriguez, MD; John Robert Rinker II, MD; Bianca Weinstock-Guttman, MD; Khurram Bashir, MD, University of Alabama at Birmingham; Jonathan Strober, MD, University of California, San Francisco; Mark Patterson, MD, Mayo Clinic, Rochester, Minnesota; and Deborah Hertz, MPH, National Multiple Sclerosis Society, New York, New York.
Financial Disclosure: Dr Yeh has received financial support for research activities from the National Institutes of Health, the Jog for the Jake Foundation, and the Children's Guild Foundation. Dr Waubant has received free medication for clinical trials from Biogen Idec and Sanofi-aventis. Dr Krupp has received personal compensation for activities with Bayer HealthCare Pharmaceuticals, Biogen Idec, EMD Serono, GlaxoSmithKline, and Teva Neuroscience; has received royalty payments from Demos Medical Publishing, Eli Lilly and Co, MedImmune, Vertex Pharmaceuticals, Wyeth Pharmaceuticals, and ZymoGenetics; and has received research support from Acorda Therapeutics and Biogen Idec. Dr Ness has received funding from the National Institutes of Health and serves as an unpaid consultant for Merck. Dr Chitnis has been a consultant for Teva Neuroscience, Biogen Idec, EMD Serono, and Bayer HealthCare Pharmaceuticals. Dr Ramanathan has received research funding from EMD Serono, Pfizer, Novartis, the National Multiple Sclerosis Society, the National Institutes of Health, and the National Science Foundation and has received compensation for serving as an editor for the American Association of Pharmaceutical Scientists (which are unrelated to the research presented in this article). Dr Chabas has received personal compensation for activities with Teva Neuroscience. Dr Rinker has received speaking honoraria from Biogen Idec, EMD Serono, Pfizer, and Teva Neuroscience and has received research funding from Biogen Idec, Novartis, and EMD Serono. Dr Weinstock-Guttman has received compensation for speaking from Teva Neuroscience, Biogen Idec, and EMD Serono and has received financial support for research activities from the National Institutes of Health, the National Multiple Sclerosis Society, the National Science Foundation, EMD Serono, Biogen Idec, Teva Neuroscience, Cyberonics, and the Jog for the Jake Foundation.
Funding/Support: The National Multiple Sclerosis Society provided financial support for the Pediatric Multiple Sclerosis Center of Excellence of the Jacobs Neurological Institute.
Additional Contributions: We acknowledge the National Multiple Sclerosis Society for providing clinical funding for the US National Network of Pediatric MS Centers of Excellence.
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117 posts tagged with neighborhoods.
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Which is safer in SE London? Shadwell, Stratford, NewCross/Lewisham?
Hello. I just got confirmation from my Uni that their accommodations are setting me up with a flat in Shadwell. It was my 3rd choice and 2 trains from my college. But just reading online, I didn't realize that Shadwell doesn't have a good reputation, has had some violent crime in recent months and has some... 'Extremist' possible group activities going on there. Therefore I was wondering if anyone has any feedback, insight or experiences w/ this and these neighborhoods in the SE London/Lewisham area who can let me know which may be better options? Here is a map link to my Flat/Dorm building. [more inside]
What's it like, living in Knoxville?
I'm considering moving to Knoxville sometime in the next 2 years. Help me figure out if it will be a good fit. [more inside]
Where to live in Cincinnati?
I am headed in Cincinnati early next month. The Mr. will be interviewing for a job, while I spend the day with a relocation specialist figuring out where we will want to live should the interview go well. The relocation specialist wants to know which neighborhoods I want to visit. Ideal living situation details below the fold. [more inside]
Moving to Portland, Maine. Where should we live?
It looks very likely that my spouse and I will be moving to Portland (the first Portland). We are both really excited about the move but don't know where to live. Help us choose a good neighborhood (and maybe a buyer's agent)! [more inside]
I have some more questions about Philadelphia.
For a while now one of my best friends has been talking about living in Philadelphia and for some reason it's only been recently that my interest has been piqued. I read this question about neighborhoods in Philly and it sounds really great, but I still have some questions. [more inside]
Neighborhood for short stay in Vienna with small child?
Hi, my family is spending a long weekend in vienna visiting a friend, and wondering where to stay. We want to be central, within easy reach of my friend (grosse schiffgasse) and in a walkable area with some restaurants and playgrounds to keep our two year old fed and entertained, and so we can stay out when he is asleep in the stroller. i don't know the city at all. any suggestions? There are place right there where my friend is staying, but it did not seem like the best choice, perhaps i am wrong. thanks [more inside]
Where should I look for a house in Raleigh/Durham/Chapel Hill?
I'm going to fly out to North Carolina, The Triangle, for a few days to start scouting for house. It's a big area. I'm not sure where to start. I work from home so the commute isn't an issue. It's more about finding a nice place to live. [more inside]
Talk to me about neighborhoods in Philadelphia
I'm an east coaster who has been living in Minneapolis for five years. I'm thinking of moving to Philadelphia in a year or more. I haven't actually spent any time there in about ten years (when I did much hanging out with punks in collective houses in West Philly), so, talk to me about neighborhoods in philly? [more inside]
Vancouver my crew!
Just found out our client has approved a film shoot in Vancouver. Hooray! Now, where do a crew of 5 Brooklynites stay? [more inside]
Moving to Longuyland, need help being more specific
We are moving to Long Island and want to live within an easy commuting distance (under 30 minutes) of Melville, where my husband will be working. We'd also like to live somewhere we can walk to get a cup of coffee. [more inside]
School ratings in Nashville... do they mean anything?
My family is considering a move to Nashville from Chicagoland next year. The idea of being able to afford living in the city center after having been trapped in the 'burbs sounds appealing. Listings at places like Zillow (via GreatSchools.org) and Trulia show ratings for assigned schools in these areas... and the ones for non-suburban schools are scary, like one to three out of ten kinda bad. How seriously should I take these ratings? I'm interested in both specific-to-Nashville comments and more general thoughts on school ratings. [more inside]
Looking for a neighborhood in Los Angeles
My partner and I are considering a move to Los Angeles. I have gathered from previous questions and short visits that thinking of "Los Angeles" as one giant city is both overwhelming and not actually helpful in figuring out whether or not we would be happy there. Can you help us narrow down our thinking to specific neighborhoods that might be a good fit? [more inside]
Middle-aged farts thinking about relocating to Phoenix/Tempe area.
We're married, no kids, early forties. Originally from Seattle, but have lived in Orlando, FL for almost a decade. We're considering an eventual move to the Phoenix area, and I'd love recommendations about what areas to consider. [more inside]
Affordable neighborhoods within half an hour of Century City
Where could I find an affordable studio within a 30 minute or so commute by car to the Century City area of L.A.? [more inside]
Where to stay in London?
I'll be in London for work at the end of the month but will also have some time for fun/sightseeing. I'm trying to figure out where to stay to maximize both. [more inside]
Orient me to Montclair / Bloomfield, NJ
We are moving to New Jersey on the Bloomfield / Montclair border. I know nothing about the neighborhoods except their reputations. Help me hit the ground running with things I should know, especially best coffee, food, shopping, parks, health services, business services and other things that wikipedia has left out. Thanks! [more inside]
Where to stay for two nights in Seattle?
My husband and I want to spent this Friday and Saturday night in a nice-ish hotel in Seattle, but we aren't sure what neighborhoods we should even be looking in. I don't know the city very well, so I could use some guidance! [more inside]
Where should I live in SF?
Mefites of San Francisco: Where do you live? Where should I live? When should I move? How does this happen? I'm a special snowflake with my own special snowflake needs. [more inside]
Looking for a subway map of NYC with neighborhood boundaries
I have been looking for a while for a particular kind of map of New york City for my office wall. Ideally it would show the neighborhood boundaries like this AND the subway lines like this. For various reasons I am not looking for an interactive or computer-based tool. I need a hard copy map (though I would be happy to print my own if there was a digital version I could license). Plenty of subway maps, and a few neighborhood maps, but I haven't been able to find them both on one map.
Neighborhoods near Cambridge?
I am considering moving for a job in Cambridge MA. I know nothing about the neighborhoods, and need help. [more inside]
Where should I live in San Diego?
In a few weeks time, I'll be moving to San Diego. What are some neighbourhoods I should be looking at? Top priorities are a reasonable commute to UCSD (no more than about twenty minutes drive, or even better shuttle access) and cheap rent (ideally not more than ~$1300/month). [more inside]
Dog-friendly DC
I have yet another "where should I live in DC?" question, but mine has a dog park twist! [more inside]
Should I move here?
I'm moving to a new apartment, and looking for a place that will be quiet and peaceful. I've found an apartment I like—based on the description on Craigslist, at least—and I just drove by in advance of the open house. The market where I live, in the Bay Area, is so tight right now that I'll probably have to apply immediately at the open house if I want a chance of getting it. When I drove by, I noticed that the house across the street was literally falling apart-- the roof had holes that were visible from the street, shingles were falling off, and the whole thing looked like it might eventually collapse. I saw someone go inside, so it looks like people are living there. The rest of the block looks ordinary enough. Having never lived near a place that looked so bad, I'm just wondering if there's anything I should be worried about. Other than the fact that it looks bad, and I feel bad for the people who have to live there (and for the house itself, which clearly was once very nice), does it matter that this place is across the street?
Help me decode New Orleans hotel locations!
I'm somewhat last-minute booking a trip to NOLA, and have never been before, so I'm floundering a bit in sorting through my hotel decisions. There's tons of advice on where to eat, but very little on where to sleep! Which we do plan to do at least once. ;) So dear MeFites, where should the boy and I park ourselves between beignets? [more inside]
Mexico City recommendations: cool 'hood, what to do, etc
I'm going to Mexico City in late October and have a bunch of questions! [more inside]
Neighborhoods and furnished or semifurnished apartments in San Francisco
What are your favorite neighborhoods in San Francisco for living, working, experiencing the city and SF life? And any suggestions for cool, interesting, off-beat housing options aside from standard corporate housing for temporary but longish term relocation? (1 year) [more inside]
Is there a large shopping/strolling/dining area in Minneapolis-St. Paul?
Visiting the Twin Cities in a few weeks with my girlfriend. She'd like to check out some walkable shopping districts with a vibrant, dense mix of stores and places to eat. But does this exist on a somewhat-large scale? [more inside]
Lodging for Two to Three Weeks in Santiago, Chile
In November I will be spending 2-3 weeks in Santaigo, Chile. This is a long awaited vacation, and I want to make the very most of it! For now, I am interested in your recommendations for a place to stay (details follow). [more inside]
Choosing the best neighborhood in Baltimore
I am moving from San Francisco to Baltimore. I've been living in the Haight Ashbury, and I like Inner Sunset, Hayes Valley, Duboce Triangle/Castro, Mission, and SoMa. Can I get a similar environment there? [more inside]
Where should I live in New York?
I'm moving to New York and don't know a lot about neighborhoods. Where should I live? [more inside]
Roxbury and Dorchester neighborhoods, Boston
Tell me about Roxbury and Dorchester neighborhoods! I've lived in Boston about ten years and am considering a move to one of those areas, but am pretty ignorant of the different neighborhoods within. Help me rectify this -- what are your favorite spots in Roxbury or Dorchester, and why? [more inside]
How can we get a good feel of Atlanta neighborhoods to live in?
I am interviewing for an assistant professor position at the Emory School of Medicine. My girlfriend and I are visiting Atlanta where we will have a rental car and most of a Saturday to look at various neighborhoods. We're less interested in seeing the inside of apartments and more interested in getting a feel for the neighborhood: what they look like and how people live outside their housing. Can you offer some suggestions on where to drive, walk, eat, drink, and visit to make the most of this day? [more inside]
Please convert Chicago neighborhoods to DC equivalents for me
Where in the DC area might I find my kind of community? Would love if you can explain the vibes of DC's neighborhoods in terms of the vibes of Chicago's neighborhoods. [more inside]
Moving to Austin. What next?
My partner and I plan to move to Austin, Texas, in January. We're looking for recommendations about neighborhoods, information about the housing market, or any other useful information. [more inside]
NY to LA Transplant Question
I was just offered a job in Los Angeles starting April of next year. We are considering it, and just starting to look around on Craigslist etc at housing/ neighborhoods. I am wondering which areas are good for our "prerequisites" which are really just things that are ideal and are in no way deal breakers: [more inside]
Where to live in Baltimore?
I'm moving from the Midwest to Baltimore in about a month, likely into an apartment sight unseen. Baltimore MeFites - I need your advice on where to live that is safe, in my price range, and would fit my lifestyle! [more inside]
NYC isn't a city, but a collection of villages...
Looking for some input on specific NYC neighborhoods... [more inside]
Headed to Beantown, but I promise not to call it Beantown.
We're moving to Boston. Where should we live? [more inside]
Help two New Yorkers navigate 3 days in Chicago
We're going to Chicago this weekend! Despite a 50% chance of rain (BOO) I am determined to have an awesome time. We will be staying in Wicker Park and plan to rely mainly on bikes and the L to get around. We aim to eat, shop and explore. Where do we start? [more inside]
Seeking model Animal Control Dept.
Is there any big city anywhere that has a really competent Animal Control Dept? [more inside]
Where should I live in south Brooklyn?
Brooklyn apartment hunting: Tell me about Bensonhurst/ Dyker Heights/ Midwood! [more inside]
Safe and boring places to live on the Amtrak train route near Emeryville, CA?
I'm looking for super-safe, reasonably nice, boring places to live in the Bay area, specifically a location that would allow me to walk to an Amtrak station and use Amtrak to commute daily to a work location that's next to the Amtrak Station in Emeryville, CA. [more inside]
Find me a home (with space enough) where the buffalo roam!
Bronx? West side of Manhattan? My kingdom for enough space for a table to eat on and a dresser. Where should I live? [more inside]
"Affordable" Bay Area neighborhoods?
Looking for an "affordable" neighborhood in the Bay Area to rent in. Criteria inside. [more inside]
Neighborhoods in Chicago for twenty-something foodie?
What Chicago neighborhood is best for a single 20-something foodie? [more inside]
Map of Los Angeles area
Is there a map available online of the boundaries of the cities around Los Angeles? For example, the map would show the streets where places like Culver City, Bell, Santa Monica, West Hollywood, etc. begin and end. Bonus points if the map shows neighborhoods within LA proper. Double bonus points if it includes light rail and commuter rail. [more inside]
Walkable neighborhood in the South?
I live in TN, in a city that doesn't offer very good mass transit, everything is spread out and I have to drive everywhere. I would love to live in a neighborhood designed for people who want to walk to the local grocery, book store, park. Not just a neighborhood that may offer a coffee house, but a true walking neighborhood, and I need to stay in this part of the South... Is there anywhere in TN or AR like that? (Nashville to west TN and central to east AR).
Crown Heights for real now.
Crown Heights, Brooklyn II: a few weeks ago, I asked this. Answers were helpful. I've now signed a lease for an apartment in Crown Heights and will be moving in early August. It would be useful if you could give me tips and hints about living in my new neighborhood. [more inside]
Help me move to London
I'm moving to London! Help me figure out where to live and how I'm going to get to work and back. Especially curious about commuting by bike. [more inside]
Pick me a new neighborhood.
Tell me about Crown Heights. Tell me about Prospect Lefferts Gardens. [more inside]


text:
[TRANSFER TALK]According to his own website, Samir Nasri, often called the next Zidane, completed the switch from French team Marseille to Arsenal of the English Premier League. The young French international, who made two substitute appearances during France's Euro 2008 campaign, announced the move Monday, claiming he signed a four-year deal with the London club. Reports on the transfer fee range from $24 million-$32 million.
Neither team confirmed the transfer of the speedy winger who turns 21 on Thursday. His agent, Jean-Pierre Bernes, claims the announcement is premature and that no deal has been reached between the two clubs.
Like Zinedine Zidane, Nasri grew up in Marseilles, where he has spent four seasons at hometown club Olympique Marseille, earning the French first division's young player of the year honors in 2007.
In the buildup to Euro 2008, Arsenal manager, Arsene Wenger, made no secret of his admiration for Nasri, claiming, "At 21 years old, his whole future is ahead of him and he has [quite] a margin for progressing further. He has, in any case, the qualities needed to assert himself at the highest level."
If his website is correct, Nasri joins five other French players on the Arsenal first team and is a likely replacement for fellow Frenchman Matthieu Flamini, who recently left for AC Milan, or Belarus star Alexander Hleb, who appears to be headed to Barcelona.


text:
December 18, 2006, 06:16 PM
Anyone know a good website that offers name-brand holsters at sane prices? I'm specifically looking for a Galco Classic Lite for my Kahr P40. Cheaper than Dirt has them for 1911's (which should fit my P40) for $59.95, or I can get it direct from Galco for $74.95:eek: Anybody seen them for less than CTD?


text:
NRS Ricksack Dry Bag - Closeout
On Sale: $15.40–$25.90
$21.95–$36.95 You Save 30%
(24) | Write a Review | Ask a Question | 7 Questions
Item: 55022.01 | Product Details »
- A rugged 19-oz.reinforced PVC body and 30-oz. PVC bottom combine to create a bag that will last for years.
- Our Storm Strip closure, in combination with a stiff PVC band, fold down for a watertight seal.
- Closure doubles as handle and a D-ring accommodates a carabiner nicely.
- Sizes are measured fully packed and closed.
Product Reviews(24)
More Information
|Filled Dimensions:
|Available Sizes
|19 oz. PVC body and 30 oz. bottom
|Closure System:
|Fold-down StormStrip™ closure
|Cu. In.
|6.5" Dia x 12.5" H
|7.5" Dia x 13" H
|9.5" Dia x 20" H
|11.5" Dia x 23" H
|9.5" Dia x 38" H
|12.5" Dia x 26" H
Keep your gear dry in the most rugged and durable transparent dry bag on the market - the NRS Ricksack.
NRS rafting guru Clyde Nicely shows you how to properly roll up your waterproof dry bag in this short instructional video. There are just a few simple steps you need to follow to get the best water-tight seal. Push out most of the air, then fold, rather than roll, the bag top. (Folding creates more sharp bends to block water entry.) Fold the top of the dry bag at least three times, then snap the buckle shut. Closed properly, NRS Drybags keep your gear dry while rafting, kayaking, canoeing and stand up paddling. The StormStrip closure on NRS dry bags is time- and boater-tested to protect your water sports gear. The StormStrip closure is used on the NRS Bill's Bag, Outfitter Bag, System 5 Bag, Expedition DriDuffel, Day Pack, Access Duffel, Tuff Sack, Ricksack and Dri-Stow Bag. It also protects and backs up the waterproof zip seal on HydroLock Dry Bags.
REVIEW SNAPSHOT®by PowerReviews
- Strong material (20)
- Waterproof (19)
- Good capacity (18)
- Tight closure (17)
- Easy to carry (16)
Best Uses
- Kayak / canoe / rafting (4)
- Paddling (3)
- Sailing (3)
- Was this a gift?:
- No (22)
Most Liked Positive Review
I can swear by more than 25 years of heavy use
It is with great sadness that I have to announce the demise of my trusty Ricksack. It has finally developed a leak on the floor seam that I won't be able to repair. I've...Read complete review
It is with great sadness that I have to announce the demise of my trusty Ricksack. It has finally developed a leak on the floor seam that I won't be able to repair. I've had this on literally 1,000s of river trips and backpacking excursions since 1988. So young, and so much it gave. It wasn't just a bag for my hypothermia kit, but I also kept a high thread-count pillow case in it, so it would be my slumber-time luxury. I will miss you. Long live the Ricksack!!!
Most Liked Negative Review
Not sure I liked this product
I purchased the XS small bag and was surprised by how much gear it holds. I thought I would really like this product to hold my camera and other gear while out kayaking. ...Read complete review
I purchased the XS small bag and was surprised by how much gear it holds. I thought I would really like this product to hold my camera and other gear while out kayaking. BUT, the first time I used the bag the clip jammed in the locked position. I had to ask for help in Morro Bay from a man repairing his sailboat to unjam the clip. I missed out on taking many good pictures because it was jammed a good 3/4ths of the time were were out with my camera inside.
Reviewed by 24 customers
Displaying reviews 1-5
Previous | Next »
- Easy To Carry
- Good Capacity
- Strong Material
- Tight Closure
- Waterproof
Best Uses
- Paddling
Comments about NRS Ricksack Dry Bag:
I use the bag for day kayaking trips. No worry about keeping important items dry, such as food, wallet, camera, etc. I can store it just about anywhere in my kayak. I like that I can see where the items are inside the bag.
Service and delivery comments:
Delivered sooner than I expected.
- Was this a gift?:
- No
- Easy To Carry
- Good Capacity
- Strong Material
- Tight Closure
- Waterproof
- No "zip lock" seal
Best Uses
- Paddling
- Sailing
Comments about NRS Ricksack Dry Bag:
Previous see-thru waterproof bag had a "zip-lock" seal that I would close before the final roll-up. This will be fine and keep the water out. Only time will tell if seals are weak or it tears easily, so the "cons" are a mute category.
Service and delivery comments:
Service and delivery was fine.
- Was this a gift?:
- No
- You Can See The Contents
- Only Lasted 27 Years
Best Uses
Comments about NRS Ricksack Dry Bag - Closeout:
It is with great sadness that I have to announce the demise of my trusty Ricksack. It has finally developed a leak on the floor seam that I won't be able to repair. I've had this on literally 1,000s of river trips and backpacking excursions since 1988. So young, and so much it gave. It wasn't just a bag for my hypothermia kit, but I also kept a high thread-count pillow case in it, so it would be my slumber-time luxury. I will miss you. Long live the Ricksack!!!
- Easy To Carry
- Good Capacity
- Strong Material
- Tight Closure
- Waterproof
- Stiff
Best Uses
Comments about NRS Ricksack Dry Bag:
This bag is sturdy and completely waterproof. For me, the only downside is that when stuffed, because it is fairly stiff it barely makes into my hold. It isn't the bag's fault, though. My kayak is older and the hatch is smaller and round not oblong. If the bag is stuffed too full it won't fit through the hatch. I had to work to stow it on our 5 day/4 night 106 mile Apalachicola River run; but it did the job it was designed for.
- Was this a gift?:
- No
- Strong Material
- Waterproof
Best Uses
Comments about NRS Ricksack Dry Bag - Closeout:
I use these to pack my kayak and camp. They are bullet-proof, as long as you close them properly. And they are nearly indestructible. Good stuff in these days of wimpy, cheapo goods.
- Was this a gift?:
- No
Displaying reviews 1-5
Previous | Next »
Do you have questions about this product?
Get answers from real customers and in-house experts with AnswerBox.
- NRS Ricksack Dry Bag - Closeout
Q:How do you repair the old style "ricksack" the clear version? Will a standard vinyl repair kick work?...thxAsked on 7/4/2016 by Lerch from Leadville, CO
5 answers
A:I have never tried to repair a dry bag and never had one tear or fail yet....but I would try the type of vinyl repair kit that we use for inflatable boats since the glue seems to really hold up well.
DeanaAnswered on 7/4/2016 by Anonymous
A:Hi Lerch. I use the NRS product Tear-Aid for repairs like that. I use Type A for just about everything, but Type B is specifically for vinyl. Both are see thru. It will last for years and won't peel off. If you decide to go with it, I guarantee you won't be dissappointed.
Sent from my Verizon Wireless 4G LTE smartphone
- NRS Ricksack Dry Bag - Closeout
Q:I am looking at your XL drybag with a length of 38". I need to fit something 34" long in it and I am not sure if that will leave enough room to properly roll it down. Can you please advise me?Asked on 6/11/2016 by Joanna from Lake Tahoe
2 answers
- NRS Ricksack Dry Bag - Closeout
Q:What about XXL size?Asked on 5/17/2016 by Fernando Baldrich
1 answer
A:Fernando, we don't make the Ricksack in XXL size. We do have that size in the Tuff Sack - http://www.nrs.com/product/2945/nrs-tuff-sack-dry-bag
- NRS Ricksack Dry Bag - Closeout
Q:How flexible is this bag in cooler temperatures? We have a few older "see-thru" dry bags made by another retailer and we love them for how fexible they are in all temps. They are strong, durable, and flexible in all temps. On the other hand, we also own a see-thru bag from yet a different retailer that looks similar to the NRS bag that is stiff when cool. The stiffness sometimes prevents getting a perfect "roll-down".Asked on 8/2/2015 by Tom from Pa
7 answers
A:I have had several other Clear bags prior to this one. Of all of the other bags, this is by far the most flexible at cool temps. It does, like all plastics get more stiff at cool temps. The Black storm seal stays really flexible, which helps with a good seal.
A:I have never noticed any difference in flexibility regardless of temps and I use the bag in temps that vary from 80's to 40's...
DeanaAnswered on 8/3/2015 by Anonymous
A:They are indeed stiffer in colder temperatures. I've use mine for paddling
in MI when temps got down into the low 30's. The bag is a bit more difficult
to roll when it's that cold, but fortunately I've not had to test the
integrity of the closure at those lower temps. There is a mesh imbedded in
the clear material that may contribute to the additional stiffness. If
transparency is not an major issue, you might take a look at the NRS Tuff
Sack. I have several that are over 10 years old and have been on many
extended wilderness trips. They are strong and flexible - assuming of course
that they are still made the same way that they were back when I bought
them. I've never had one leak or tear. Last time I looked, they didn't make
a clear one though.
A:Tom, they will be somewhat stiffer at low temperatures; PVC has that quality. I do think the nylon scrim that runs through the material helps dampen that effect. I suspect the bags you have that are flexible at all temps are made with urethane, which has that flexible property.. Our HydroLock Bags, Items # 55025.01 and 55027.01, are urethane-coated nylon, with a clear urethane window.Answered on 8/2/2015 by Clyde from NRS
A:huh, interesting problem. I've never had a problem with rolling my see-thru bag. Hot or cold, it's always worked great.Answered on 8/2/2015 by Anonymous
- NRS Ricksack Dry Bag - Closeout
Q:How much does the XL rucksack weight?Asked on 9/7/2014 by v from Manchester uk
1 answer
A:The XL weighs 1.8 pounds.Answered on 9/8/2014 by Clyde from NRS
- NRS Ricksack Dry Bag - Closeout
Q:You spec the large NRS HydroLock Dry Bag at 12 oz. What is the weight of the large Ricksack?Asked on 8/7/2014 by Scott, the picky buyer from Oakland, CA
2 answers
A:Scott, the Large Ricksack weighs 1 lb, 7 oz.Answered on 8/7/2014 by Clyde from NRS
A:The HydroLock bags are lighter than the RickSack. The RickSack is about
the same weight as the TuffSack bags. I don't have a scale, but would
guess that is the HydroLock is 12oz, the RickSack is around 18-20 oz.Answered on 8/7/2014 by Anonymous
- NRS Ricksack Dry Bag - Closeout
Q:Is the length dimension measured when fully unrolled?
Thank you.Asked on 1/2/2014 by Scott from United States
2 answers
A:Scott, we recommend three folds of the StormStrip closure to get a good watertight seal. The length dimension is taken when the bag is sealed this way.Answered on 1/2/2014 by Clyde from NRS
A:Hi fellow shopper;
The measurement 12.5 H is with the black strip that holds the buckles, folded twice as stated in the product infor tab.
"Sizes are measured fully packed and closed".
My xs bag measures 19 inches high, when it is empty and unrolled. But packed and folded correctly it is about 12".


text:
Luis Gil May Be The Future Of US Soccer, But He Is RSL's Present
Luis Gil has been labeled as "The Next Landon Donovan" and the "Future of US Soccer."? He has been compared to even Cesc Fabregas and was pursued by Arsenal when he was just 16 years old.? Although the young sensation has yet to get his first cap with the senior squad, he is almost unanimously considered by United States Men's National Team fans as the face of the next generation.
But there is one person that isn't buying it just yet: Luis Gil.
"I kind of try to push that stuff to the side because obviously you just don't know right now," Gil told Sports Talk Florida in an exclusive interview.? "I'm still only 18.? I still have a lot ahead of me and a lot of work to do.? Right now, I'm just trying to be the best player I can be.? Obviously, it's a good thing to be compared to Landon Donovan, but I'm just trying to be the best player I can be right now."
The 18 year old has already represented the United States at the 2009 u-17 World Cup in Africa and called the experience one of his favorite moments of his young career.
"I felt like that was a big accomplishment for me... The whole opportunity and the [entire] time being there was a [great] experience: being in a country I've never been to and obviously representing my country in a World Cup."
See Luis Gil and Real Salt Lake take on the Seattle Sounders in the second leg of their quarterfinal match-up Thursday at 10:00 pm EST on NBC Sports Network
When he was 16, Gil had the opportunity to go on trial for Arsenal, and afterwards was offered a contract.? But he decided to stay at home and sign with MLS instead of going overseas.
For those unfamiliar with the system, MLS is a single entity unlike teams from most other countries.? This basically means that a player is actually owned by the league itself, rather than the teams.? The league cuts their checks, and assigns them to teams through drafts, lotteries, trades, etc.? Most American leagues follow this model.
In Europe, it is a free market system, where any team is free to purchase and sell any player it wishes at a price of mutual agreement between the parties involved.
So in choosing MLS over Arsenal, Luis did not know which club he would eventually be assigned to.
Gil was placed in a weighted lottery, with his rights being awarded to Kansas City before being traded to Real Salt Lake.? [The trade is actually a vital side note because RSL have one of the best development systems and progressive-minded coaches in the league, leaving Gil in very capable hands.? Whereas, Kansas City were in the midst of a massive transition at the time of his entrance into the league, which eventually included even the name and branding of the team.]
But Luis says staying in the USA was ultimately the right choice.
"So far the RSL organization has been [developing] me well, so I feel like it was a good choice coming here," Gil says.? "My first year [they taught me] patience.? I was only 16 coming into the league and obviously they didn't want to force me into games and stuff like that because it can be difficult."
There are still aspects of the game Gil can work on.? He is only 18 and even with the hype, he understands he has a long way to go still before he truly arrives.
"[I need to work on] understanding the game a little more.? I'm still growing as a player.? [Playing] defensively has been a big thing with me but I have been putting in work with that and paying [close] attention to it; being more physical and stuff.? That's one of the biggest things I have been trying to work on."
One thing is for certain with Luis Gil, he certainly has his head on his shoulders and is definitely a guy all US Soccer fans can root for.
Listen to the audio below:
[audio:1040/Vince/Luis_Gil.mp3|titles=Luis Gil Interview]


text:
You can bet on everything these days, maybe even the odds of you reading this column to the end.
Even Monday's presidential debate had prop bets … the color of Donald Trump's tie (blue paid $160 for $100 wagered), would Hillary Clinton mention Melania Trump (had to wager $250 to win $100) and the one I liked the most, would Trump mention "build a wall"? My buddy guessed no and took home $48 on a $20 wager.
Let's return to more conventional stuff now. Please note: Selections are in bold and are against the spread. And the lines, taken from Pregame.com at noon Thursday, might have shifted.
Rutgers (plus 38.5) at Ohio State: Look at that...


text:
Officials at the Pennsylvania Turnpike have fired 12 employees in recent months as part of continuing investigations into theft, waste, and corruption.
Seven toll collectors, one equipment operator, and four management employees, including the turnpike's director of maintenance, "have been terminated as a result of findings from the OIG [Office of Inspector General] and other internal investigations," Turnpike Commission spokesman Carl DeFebo said.
In addition, "the commission this year has referred a number of cases to external agencies for further investigation and possible prosecution, but we cannot provide details as the cases involve ongoing investigations," DeFebo said.


text:
San Francisco's Bold Italian Flavor
For decades, Kuleto's has welcomed new guests and treasured old friends, right in the heart of San Francisco's Union Square.
Even before our guests get up, we're on the road sourcing San Francisco's freshest ingredients.View Menu
I was recommended this restaurant by the nicest lady working in saks! I'm so glad I tried it because it was amazing.
Awesome restaurant! The food is absolutely amazing. I come here every time I visit San Francisco. Their grilled radicchio appetizer is such a unique and complex taste.
Had an excellent dinner last night at Kuletos. From the opening course ... to the wine.... to the service all the way through dessert and coffee I give Kuletos a well earned FIVE STARS!
One of my favorites in SF. Duck Bolognese was so rich and flavorful but not heavy. Homemade bread was awesome. Spinach salad with roasted peppers and goat cheese with pine nuts was a wonderful combination.
of Hours
Weekdays 5-7PM
Villa Florence Hotel
221 Powell St, San Francisco, CA 94102
Hours of Operation
Monday-Friday 6:30AM - 10:30AM
Saturday & Sunday 7:00AM - 10:30AM
Sunday-Thursday 11:30AM - 10:30PM
Friday & Saturday 11:30AM - 10:30PM


text:
Lefthanded 308 AR type rifle
Tools and Technologies
Rifle Country
> Lefthanded 308 AR type rifle
April 23, 2010, 11:12 PM
Does anybody make a 308 lefthanded AR type rifle with a 24" barrel?
If you enjoyed reading about "Lefthanded 308 AR type rifle" here in TheHighRoad.org archive, you'll LOVE our community. Come join
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April 24, 2010, 01:20 AM
I believe Stag arms has a couple. I have no experience with them though...never mind you said .308
Reading comprehension>me
April 24, 2010, 05:02 PM
Depends on your definition of "lefthanded".
AR10's are .308 and ambi Ar15 controls often fit them.
Stag ambi safety
BCM charging handle (comes in a .308 size)
Troy mag release (coming soon)
magpul bad lever
Left side ejection- no. Not needed anyway. I'm primarilly a lefty, I shoot standard AR's with ambi controls. Tactical rifles should be used with both arms/eyes, so don't let which side the case ejects out of influence your decision. Just research ambi controls instead.
April 24, 2010, 08:50 PM
I am left handed and have narrow feet. I have heard 1000's of time WHEN THE STORE DOES NOT SELL A WIDTH SHOES, these run narrow. THEY NEVER DO. The same with left handed persons shooting right handed rifles. The cast is a problem, controls an issue and the ejection port a biggest problem. I shot right handed rifles for years I am old but in the past 25 years left handed models have become more available. To my knowledge and I have been looking for one for years there are no 308's in left hand. Stag makes a 223 in left hand. There are also no left handed 20 ga's either.
April 24, 2010, 09:39 PM
On an AR style weapon there is no cast built into the gun,so it doesn't matter which hand you shoot.
I own several,and I shoot lefty,and have never had an issue with brass coming out the ejection ports or operating the controls.
On shotguns,get a Browning BPS or an Ithaca 37 20ga pump. Both are bottom load/eject,so either are left handed or right handed.
Remington used to make the 870 & 1100 in left handed 20ga-find a used one.
April 25, 2010, 11:15 AM
Get an M1A....
The AR-type is inherently righty, and since i prefer my Mini to my AR, when i looked for a semi .308, M1A is the obvious choice.
Also, FAL-types are the worst for lefties.
On shotguns, are you guys just referring to autoloaders and pumps? I've never had nearly the issues with running any type of shotgun lefty as i have with most rifle types.
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text:
68,375 words (≈ about 5 hours)
TQF27 presents a marvellous novel in full: Operation 1848 by Mike Schultheiss! Plus two short stories: "Orchid Strangelove and the Kiss of the Taipan" by Sam Leng and "Lost Futures" by Cyril Simsa. The issue is rounded out with the usual half-baked reviews, news and editorial musings.
Language: English
Written in: 2009
Published: 2008-12-18
Word count: 68,375 words (≈ about 5 hours)
Tags: science fiction, fantasy, horror, magazine, tqf
Stephen Theaker is the co-editor and publisher of Theaker's Quarterly Fiction, and the compiler of the British Fantasy Society's review magazine, Shelflings. His reviews have appeared in Interzone, Black Static, Prism and the British Fantasy Society Journal. His novels are not well-regarded.