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We offer a variety of corporate programs that show attendees how to create and sustain positive energies in their everyday life, and keeps them engaged, guessing and excited.
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The Elder Scrolls V: Skyrim
- Boards
- The Elder Scrolls V: Skyrim
- Do you want TES to take a more mature route?
GriffRoberts 4 years ago#62
From: BenjUK55 | #051
Well, if we are looking at the context of the game, once again being based upon medieval/middle-age Europe, then sexism would be an obvious theme. The entirety of western politics/culture has been built upon a patriarchy.
Please note that this aspect isn't present in the TES universe; women more or less have an equal standing among men in Tamriel. Many times in stark contrast to medieval western Europe. One of the lore-masters can correct me if I'm wrong, but Tamrielic cultures are not very sexist.
I think Bethesda did a fine job balancing the dark humor and mature themes in Fallout. After what they did with Fallout 3, It's obvious they know how to do it. Which leads me to believe that that's just not part of their vision for TES.
Sometimes I edit my sig so it continues whatever I was posting about.
katiekat3001 posted...
Stale gimmick, and trying WAY too hard to misspell things.
That said, I agree with a lot of what you said.
Solgers? Lol...
Remember: IamI3rian told ya.
I could write a book about what you don't know. --Skeletor
GriffRoberts posted...
From: BenjUK55 | #051Well, if we are looking at the context of the game, once again being based upon medieval/middle-age Europe, then sexism would be an obvious theme. The entirety of western politics/culture has been built upon a patriarchy.
Oh yeah I see that in TES sexism isn't an issue, what I said was in reference to The Witcher 2.
Yeah perhaps I am barking up the wrong tree in asking for this kind of content inside the Elder Scrolls. Personally, it would enhance my own gaming experience. Maybe it should be left for Fallout after all.
We do not sow.
The_Real_Turnip posted...
BenjUK55 posted...Fair enough. That doesn't necessarily make it sexist though, but I see what you mean.
No, that's not true. If the cards are used or intended in a derogatory manner, then it is sexist. Not being able to collect cards for guys you have sex with is most likely down to the PC not being homosexual and therefore not being able to have sex with guys.
Before that being taken as sexist/homophobic, it entirely depends on the reasoning why they made the PC heterosexual.
Most likely, it is because of the market. Sex and sexuality sells and, unfortunately, there is still a very bad stigma attached to homosexuality and still an obsession with over sexualised women. This is most likely the reason why the cards exist and having sex with men doesn't.
However, the question is is this a fault of the gaming company who (re)produce the idea, a fault of the consumers who want the idea or a fault of the narrative/culture that creates the need for the idea?
Anyway, as I was saying, it entirely depends on the context in which the cards are used.
We do not sow.
Justin2Krelian 4 years ago#66
I think the atmosphere these games works better for them than a more Game of Thrones type style would.
I would be fine with a Dragon Age/Mass Effect type of maturity.
The_Real_Turnip 4 years ago#68
BenjUK55 posted...
However, the question is is this a fault of the gaming company who (re)produce the idea, a fault of the consumers who want the idea or a fault of the narrative/culture that creates the need for the idea?
Bolded the answer to your question. Other games allow you to seduce people, but don't have "conquest cards", or need them. Until the Witcher I'd never even heard of the concept, let alone heard demand for it. So it's not the consumers, the culture or the narrative - since all those things existed before the game did. It's the game's designers. Yeah, their customers expect it now, after The Witcher 1, but that doesn't mean it wasn't their fault originally.
It is still sexist since it quite treats your female conquests as literal trophies. Awarding you them, in point of fact. Even if they weren't startlingly gratuitous (compared with the rest of the game) they'd still be sexist since you're explicitly getting a trophy for being a memetic sex god. The only excuse would be if you could abuse any gender in this fashion, but you can't (it'd be a flimsy excuse anyway).
Keep in mind that I don't actually care that The Witcher is sexist. It's a common theme in period work, and a small(er) part of the established setting in the books. That's not bad.
So bring back Deseles house of earthly delights ?
Ruthlessness is a kindness of the wise
violentdissmay 4 years ago#70
If Bethesda took a leaf out of The Witcher 1&2
If Bethesda copied the Witcher series it would be very unenjoyable, granted, the voice acting would still be lousy but the Witcher was just terrible.
TES really needs to work on animation imo, my greatsword swings to the right, my enemy does a pirouette to the right etc, Bethesda needs to work on the technical aspects of the game before grittiness if they want realism.
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EDES- Efficient Dynamic Selective Encryption Framework to Secure Multimedia Traffic in Wireless Sensor Networks
In this paper, the authors propose a new framework able to ensure security, multimedia quality and energy efficiency in Multimedia Wireless Sensor Networks (MWSNs). The energy is an important and limited resource, which has a direct impact on the lifetime of nodes in MWSNs. In addition, the characteristics of MWSNs ...Download Now
Peer-Assisted Content Distribution on a Budget
In this paper, the authors propose a general framework and present a prototype implementation of peer-assisted content delivery application. Their system - called Cyclops - dynamically adjusts the bandwidth consumed by content servers (which represents the bulk of content delivery costs) to feed a set of swarming clients, based on ...Download Now
A Semantic Analysis of Wireless Network Security Protocols
Gorrieri and Martinelli's tGNDC schema is a well-known general framework for the formal verification of security protocols in a concurrent scenario. The authors generalise the tGNDC schema to verify wireless network security protocols. Their generalisation relies on a simple timed broadcasting process calculus whose operational semantics is given in terms ...Download Now
A Timed Calculus for Wireless Systems
The authors propose a timed broadcasting process calculus for wireless systems where time-consuming communications are exposed to collisions. The operational semantics of their calculus is given in terms of a labeled transition system. The calculus enjoys a number of desirable time properties such as time determinism: the passage of time ...Download Now
A Calculus of Trustworthy Ad Hoc Networks
The authors propose a process calculus for mobile ad hoc networks which relies on an abstract behaviour-based multilevel trust model. The operational semantics of the calculus is given in terms of a labelled transition system, where actions are executed at a certain security level. They define a labelled bisimilarity over ...Download Now
Semantic Analysis of Gossip Protocols for Wireless Sensor Networks
Gossip protocols have been proposed as a robust and efficient method for disseminating information throughout large-scale networks. In this paper, the authors propose a compositional analysis technique to study formal probabilistic models of gossip protocols in the context of wireless sensor networks. They introduce a simple probabilistic timed process calculus ...Download Now
Financial Development And Innovation In China: Evidence From The Provincial Data
This paper investigates the role of regional financial development, in addition to FDI, for regional innovation in China, using a more recent provincial dataset and more sophisticated panel data estimation techniques than those available in the literature. Two aspects of regional financial system development are considered: its financial depth and ...Download Now
Adding Preferences to Semantic Process Model Matchmaking
The capability to easily find useful services satisfying non-functional constraints is critical for building service oriented systems. Current approaches for service retrieval with these kinds of constraints are mostly limited to atomic services. However, these approaches are not sufficient and do not fulfill user needs since many non-functional factors are ...Download Now
On the Robustness of BitTorrent Swarms to Greedy Peers
The success of BitTorrent has fostered the development of variants to its basic components. Some of the variants adopt greedy approaches aiming at exploiting the intrinsic altruism of the original version of BitTorrent in order to maximize the benefit of participating to a torrent. In this paper, the authors study ...Download Now
Cloud-Based Content Distribution on a Budget
Cloud computing has emerged as a compelling paradigm for deploying Information and Communication Technology (ICT) solutions on the Internet, because it enables solution providers to easily scale up or down, or migrate their offerings seamlessly across resources - computer servers, storage, platforms, and services - offered by one or more ...Download Now


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Results 21 to 25 of 53
September 7th, 2013 01:38 AM #21Cynthia/Luna
twenty-something name nerd. infj
Seraphina Juliette Audrey. Evangeline Laetitia Odette. Catalina Ariadne Helen. Valentina Bellatrix Yvaine
Violetta Catherine Lenore. Isabelle Faustina Clare. Rosalind Anna Belphoebe. Guinevere Cassia Ottilie
Vanessa Rose Aphrodite. Helena Edelweiss. Talitha Caroline. Aurelia Madelief
Peregrine Lysander James. Gavriel Alexander Callum. James Luca Auberon. Edmund Frederic Altair
Perseus Arthur Flynn. Cassius Jason Alaric. Damien Alexei Orion
September 7th, 2013 02:26 AM #23Senior Member
Eudora - Dorothea - Violetta - Odelia - Augusta - Odette - Isolde - Ondine - Leopoldine - Amaryllis - Sixtine -
- Join Date
- Feb 2013
- Location
- Sydney Australia
- Posts
- 2,047
Eulalia - Aurelia - Marigold - Ariadne - Viola - Cosima - Philomena -Enid - Rosalind - Marguerite - Honore
Averil - Caius - Casimir - Edmund - Ignatius - Benedict - Virgil - Raphael - Leopold - Clement - Caspar - Rainer - Romain - Ernest - Isidore - Wenceslaus - Balthasar - Peregrine - Gilbert - Cornelius - Augustine - Carlisle - Quentin - Severin - Castiel - Cyril
September 7th, 2013 02:59 AM #25
Alice - over used lately
Anne - over used period
Audrey - nice, prefer Aubrey
Blythe - bland
Cecilia - lovely, also try Cecily
Clara - classic
Cordelia - spunky
Daphne - quirky
Edith - ok, not special
Eleanor - seems this old lady name is getting too much trend right now
Florence - a city and eggs, not very pleasant sound
Greta - just ok
Harriet - harsh
Henrietta - classic, lot of charm
Iris - lovely, great alternative flower name
Jane - classic
Lucille - sounds ill even though its pronounced eel
Lydia - lovely
Mabel - ok
Mae - spell May, dont make a child correct people her whole life. ps its boring any way
Margot - maggot
Mattea - reminds me of Tyler Perrys Madea skip
Miranda - always feels like a pagan name to me, idk why, the mir and anda also just seem to clash each other
Penelope - way too trendy
Rosalind - ok, prefer Rosavine or Rosemarie
Saffron - exotic without being dated like Jade or Eden
Susannah - love this sound, classic
Sylvia - lovely
Ursula - evil octopus and evil twin, skip
Violet - lots of buzz, but feels classici do not ignore the Rich Text toolbar provided me. i bold, italicize, enlarge, underline and CAPITALIZE for emphasis, individuality, and to capture attention among the endless Arial Standard Size Font that everyone else uses.
i am not screaming nor will i cosset you. i do this to highlight the most important aspect of my thoughts so they are not lost again in the never ending sea of tiny, black, tempered letters that make up forums everywhere.
~*~ i encourage you to do the same ~*~
September 7th, 2013 03:36 AM #27
Thanks for all the replies everyone! After a bit of studying, I see the most popular name is Alice by far! Zero votes for Anne, Mae, Mattea, Miranda and Ursula. And only one for Susannah! Sacrilege! It's probably my favourite Anyway, I've made some brutal cuts and have narrowed by almost half from 30 to 16...
I've deleted: Anne, Cecilia, Cordelia, Daphne, Edith, Eleanor, Florence, Greta, Henrietta, Iris, Mae, Penelope and Ursula.
I'm pretty sure I'll wind up changing my mind! But this is my top sixteen for now.~ Mother of Violet Elizabeth Rose ~
September 7th, 2013 03:56 AM #29Senior Member
- Join Date
- Jan 2012
- Posts
- 1,209


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Hotels in Koelleda, Germany
Search & Compare Koelleda Hotels
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Trending now in Koelleda
Hotels in Koelleda
45 people looked at this hotel in the last hour
Most recent review
"We had spent the day with family in Koelleda and needed a place to stay in the area as we were meeting a friend the next day in Erfurt. Hotels.com recommended the Best Western Premier Grand Hotel Russischer Hof and we were not disappointed. Staff was friendly and professional. The rooms were c..."
A Traveller, Jul 2016, US
35 people looked at this hotel in the last hour
Most recent review
"The rooms were good - clean and comfortable, and the staff was nice. The hotel is located in front of a big bus/train station so at times it was a little noisy. Parking in front of the hotel was not cheap (2.5 euros for 2 hours). "
A Traveller, Aug 2016, US
33 people looked at this hotel in the last hour
Most recent review
"The hotel is 10 minutes drive from the centre of Weimar and only a bit longer on the very convenient No.7 bus from almost outside. Do not consider trekking on foot from the station along the pavement-less main road. When you're there it's a very pleasant hotel and good value."
A Traveller, Sep 2014, US
30 people looked at this hotel in the last hour
- Hotel ResidenzNo Guest Reviews yet
28 people looked at this hotel in the last hour
24 people looked at this hotel in the last hour
Most recent review
"i didn't appreciate the $2 additional fee for usage of a credit card payment, since this was not disclosed at the time of booking. other than that, the rooms were nice quirky cute and clean. kitchen fully stocked, location good. gripe about auxiliary staff (seemingly in charge of group meals) -th..."
A Traveller, Aug 2015, US
- Hotel Weisser SchwanNo Guest Reviews yet
7 people looked at this hotel in the last hour
- Alter AckerbuergerhofNo Guest Reviews yet
6 people looked at this hotel in the last hour
Hotels within 20 miles of Koelleda
23 people looked at this hotel in the last hour
4 people looked at this hotel in the last hour
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"We had a wonderful little apartment (bedroom and eat-in kitchen with bath). The proprietor was wonderfully helpful and the location is right in the center of town. I will definitely book this again!"
A Traveller, Jul 2015, US
Best hotels in Koelleda
If you are looking for Koelleda hotels in a particular area, you can use the search feature at the top of the page to search by neighborhood, landmark, address or zip code, or you can search by using the built-in map feature. You can also browse hotels in Koelleda by type, amenities, and star-rating so that you can find the best hotel. Currently, top rated hotels in Koelleda are:
- Best Western Premier Grand Hotel Russischer Hof
- Hotel Kaiserin Augusta
- Hotel Anna Amalia
- Appartements Am Theater
- Labyrinth Hostel
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If you are looking to score the best discounts and deals, use the filter to sort by price from low to high. You can book a hotel in Koelleda for as low as &PricesFrom per night. If you are looking to cut down on expenses, look for hotels that include free breakfast and parking. Some hotels even offer free shuttle service to and from nearby places. You can also sort by star rating, proximity, and guest rating.
Before you book, check out user reviews. Hotels.com has 0 reviews in Koelleda. We show reviews from Expedia and TripAdvisor so you know that you are reading genuine, reliable reviews. Be sure to download the Hotels.com app so you can book your reservations on the go, view amenities, and save the hotels you want to view and compare later.


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Nimbuzz - Call is a leading Voice over IP Solution (VoIP Solution) Provider and System Integrator. It is dedicated to delivering Customer Management and Billing Solutions for entrepreneurs, carriers, VoIP Calling Card Operators and Corporate companies based on VoIP.
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Use Nimbuzz to share files such as photos, music and video with your buddies across all supported comunities.
Robot Fight is a action packed arcade game , take control of a robot and fight other players in a split screen environment, challenge your friends and family members to see who's best , the controls are few in number and it's easy to play. Have fun destroying robots.
Nimbuzz Calls is one of the leading VoIP (Voice over Internet Protocol) Service Provider specialising in Internet Telephony Solutions for various businesses, Our vision is to emerge as a major VoIP Service Provider by integrating telephony system with the contemporary online world.
RoboExplorer is a suite of software for setting up and maintaining the programs, teach points and robot configuration on the Mitsubishi robot controllers.
It lets you to :
- download robot programs to the controller
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The game rewards robots with the best strategies rather than those with the most efficient or best written code. This allows even inexperienced programmers to compete with more experienced professional programmers. If your robot is smarter and more adaptable than another player's robot, your robot will win even if your code is less efficient.
Zeus is an easy-to-use Intelligent, Internet Robot, that creates traffic to your web site. Generate thousands of link trades by finding web sites and automating 95% of the work in Link Marketing. The original and only robotic, link trading tool.
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Driver Robot is a powerful shareware utility that has been designed to help us update all our drivers in one go. This application features a cool graphical user interface very easy to manage by everyone. We can schedule the program for automatic scan at a time interval, shut down the computer after the downloads have finished, reset to the previous state, save changes, and so on.
Autodesk Robot Structural Analysis Professional software provides structural engineers with advanced building analysis capabilities for large and complex structures. The structural analysis software offers a smoother workflow and interoperability with Autodesk Revit Structure software to extend the Building Information Modeling (BIM) process.
Green Planet is the beautiful home of the little mechanical life forms known as "Minirobots". It was invaded by an army of ruthless robot troops that call themselves "The Machines", who wanted to turn it into a space resort! Help the peace-loving Minirobots fight to reclaim their homeland.
Memory Card Recovery Robot is a memory card recovery application for SD Card, SDHC Card, microSD Card, MMC Card, xD Picture Card, miniSD Card or CF Card. Before starting using Memory Card Recovery Robot to recover your files, please make sure you have put your memory card in a card reader and connect it to your PC.
Email Generator Robot is a bulk email address generate application. This tool makes email list based on user-defined keywords, not randomly generated, so the success rate is very high. You can get mass email IDs in really short time by the press of one mouse click.
Robot Arena 2 (Design & Destroy) is a game where you create robots. It is a sequel to the original Robot Arena. We make robots and use them to fight with other robots. Multiplayer support will be possible using GameSpy website. If you are interested in electronics and robotics, you will like it.
Autodesk® Robot™ Structural Analysis software provides structural engineers with advanced structural analysis capabilities for large, complex structures. The software offers a wide range of analysis capabilities that enable you to investigate the linear and true nonlinear behavior of any structure.
Article Marketing Robot is the Internet's most talked about article marketing solution available. It is a feature rich application that will streamline how you do your article marketing allowing you to focus on more important tasks. rticle Marketing Robot is a completely automated backlink building tool to help drive your website to the top of the search engine rankings.
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Case Study: Innovating Patient Experiences with CollaborationCollaboration
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Sexiest Stars of Summer 2012: The Ladies
Our countdown of 22 sizzling actresses primed to burn up movie screens this season
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Alice Eve
Age: 30
Can be seen in: "Men in Black 3" (May 25)
Fun fact: Eve came close to playing Emma Frost (a.k.a. The White Queen) in "X-Men: First Class", a role that ultimately went to January Jones.
Photo Credit: Columbia Pictures


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Comedy film 'Oconomowoc' sets local premieres
The comedy "Oconomowoc," the feature-film debut of Lawrence University graduate Andy Gillies, has its first Milwaukee-area showings at four theaters in the next two weeks.
Filmed in the title western Waukesha County community, "Oconomowoc" centers on a twentysomething, played by fellow Lawrence alumnus Brendan Marshall-Rashid, who moves back home with his mother and stepfather and agrees to help a friend rebuild his mishandled T-shirt business. »Read Full Article(3)
Ratings snapshot reveals Milwaukee radio trends, sort of
Math is not my strong suit. And yet I'm faced with a multitude of fractions, decimals, percentages, frequency (FM) and amplitude (AM) modulations and average quarter-hour shares when reporting radio ratings and dial locations.
Radio stations take the ratings results very seriously. But not more so than A.C. Nielsen, which bought the Arbitron ratings company last year. »Read Full Article(4)
Bastille coming to Milwaukee Theatre Oct. 18
Bastille's "Pompeii" is all over alternative and pop radio, but the first U.S. station that put it into regular rotation was WLUM-FM (102.1) in Milwaukee.
On Oct. 18, the band comes back to thank some of its earliest fans with a show at the Milwaukee Theatre. It'll be Bastille's first headlining show in town, after opening up night one of WLUM's Big Snow Show concert last December at the Rave's Eagles Ballroom, for Grouplove, Alt-J and Phoenix. »Read Full Article(5)
Top of the Charts: A 'Fancy' third week at No. 1
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No. 1 hit June 16, 2014 »Read Full Blog Post
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American Players Theatre begins its season in 'Earnest'
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On Tap Today: Jeff Tweedy and a free movie
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This product can be found in: Bird Feeders: All | Wild Bird & Garden Wildlife: All | Wild Bird Care Special Offers | Wild Bird Feeding Stations
Gardman Complete Wild Bird Feeding Station Kit
Product Code: LS7426D
The Gardman Wild Bird Complete Feeding Station includes seed, suet, peanut feeders and a bird bath.
5 x decorative hooks with a finial
1 x large micro mesh feeder tray
2 x Black steel seed feeders
1 x Premium suet feast feeder
1 x Black steel peanut feeder
1 x large split level bird bath with a support ring
This feeding station will entice a wide variety of wild birds into your garden. It features all that you could possibly need to feed, bathe and water your feathered friends. It would also make a great gift for the bird lover in your life.
- Requires self-assembly.
- Extra strength screw together poles and quick fitting accessories.
Full height: 226cm
Height Above Ground: 185cm
Width: 58cm
Customer Notes: Treats and seeds are not included. The location of your garden and the type of vegetation immediately around it will determine what birds will visit your feeding station, and in what numbers. Siting is very important - birds will only use it if they feel safe. Also wild birds get excited and pre-occupied about bathing, and tend to be more vulnerable than at other times. Make sure birds have clear visibility as they bathe, with bushes or trees nearby to provide cover if alarmed, and perches to use when preening.
Customer Ratings & Reviews
Great purchase posted on 10/08/2016 by Liz
Great addition to our garden. Birds love the range of food which can be provided on this simple feeder. Provides hours of enjoyment! Excellent buy.
Loved it posted on 15/06/2015 by pat04070
this is the second item i have bought from greenfingers and both have been brilliant. I will continue to purchase from them top quality and great delivery time
posted on 05/05/2015 by
Quick and easy to put together. Quick delivery.
GUARANTEED TO SEE LOTS OF BIRDS! posted on 25/03/2015 by dc10b
Love the bird feeding station we ordered. Was delivered quickly and well packaged. Has attracted lots more birds to this part of our garden - blue tits, great tits, robins, woodpecker, greenfinch, long tailed tits and chaffinch :-) A very happy customer!
excellent product posted on 13/03/2015 by joydennis
good strong product, easily assembled and has everything needed included in the price.
Quality at a great price posted on 27/02/2015 by Duncan Curtis
Fairly easy to assemble does need a little bit of effort to bury the spike deep enough but overall we are delighted with the feeder Within no time the birds are feeding bathing and enjoying the feeder
A great feeding staion for all birds and the occasional red squirrel posted on 26/02/2015 by Summerhouse
I found that the assembly of this bird feeding station a bit arduous due to the poor assembly instructions the diagrams could have been clearer However once assembled I found it to be very robust and multi feeding staion
Really thrilled with this item posted on 19/02/2015 by mandathorpe
Received Bird Feeding Station within stated delivery time Impressed with really good packaging Instruction leaflet was easy to follow and Feeding Station was assembled and sited in garden in no time at all Looks fantastic Birds soon flocked to get food and we had a wonderful time watching them trying to get on feeders at the same time All I can say now is thank you for such a wonderful product and superb service and price was really good as well Quality is best I have seen I have already been recommending it to my friends
Great product great service posted on 22/01/2015 by ChrisS
Usual standard from this Company which I would not hesitiate to use again
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In the first of three interviews Dezeen filmed at pop-up shops during Clerkenwell Design Week this year, Theo founder and Pigeon Light (above) producer Thorsten van Elten explains how the internet is changing the way design is sold (+ movie). More »
Tag: Pop-up shops
Thorsten van Elten at
Illy Shop by Caterina Tiazzoldi
Urbanears at Boxpark by 42 Architects
The translucent back wall of this pop-up headphone shop changes colour in response to the noise made by Christmas shoppers. More »
Dezeen archive: pop-up shops
Dezeen archive: following this month's opening of our pop-up Christmas shop The Temporium (bottom left), here's a look back at all the pop-up stores we've featured on Dezeen. See all the stories »
The Temporium at 65 Monmouth Street
Our pop-up Christmas design store The Temporium has opened at 65 Monmouth Street in Seven Dials, Covent Garden in London. More »
Dezeen Space
at 54 Rivington Street
Dezeen editor-in-chief Marcus Fairs gives a tour of our activities at Dezeen Space in this movie filmed on the last day at 54 Rivington Street in London.
Dezeen Space was open from 17 September to 16 October and hosted our latest Dezeen Watch Store pop-up, the launch of our new Dezeen Book of Ideas, specially commissioned sculptures by Dominic Wilcox, a new product launch by Paul Cocksedge, the Dezeen Lounge furnished by Ligne Roset and a micro-exhibition that changed every day.
WUHAO @ The Teahouse
Beijing Design Week 2011: visitors were served tea at a heat-sensitive colour-changing table in a pop-up teahouse for Beijing Design Week. More »
Zuo Corp by Super Super and Inside/Outside
Mirrors lining the ceilings and walls of a tiny pop-up clothing shop in Warsaw create the illusion of endless rails of garments. More »
Dri Dri at St Martins Lane by Elips Design
A pop-up Italian ice cream stall at St Martins Lane Hotel in London evokes the seaside with yellow beach huts and striped decking. More »
Farmiloe Building at Clerkenwell Design Week
Here are some snaps from the Farmiloe building at Clerkenwell Design Week in London last week, including our Dezeen Watch Store pop-up.
Dezeen Watch Store at Clerkenwell Design Week
Dezeen Watch Store: our latest Dezeen Watch Store pop-up is now open as part of Clerkenwell Design Week in London. More »
Arnsdorf temporary concept store
by Edwards Moore
Australian studio Edwards Moore have stretched tights across the walls and throughout the interior of this pop-up fashion store in Melbourne, Australia. More »
Aesop at Merci by March Studio
Melbourne practice March Studio have trapped 4500 cardboard boxes behind netting in this store for Australian skincare brand Aesop. More »
The Temporium opens
Our pop-up design store The Temporium has opened in London! More »
Eat Drink Design at Dutch Design Week
Dutch Design Week 2010: design studio Moon/En/Co curated a pop-up exhibition restaurant for the fifth consecutive year during Dutch Design Week last month, featuring pieces by designers including Kiki van Eijk and Maarten Baas. More »
The Poundshop interior by Asif Khan
for Household and Sara Melin
Tokyo Bike store by Emulsion
The interior of this temporary store in east London for bicycle brand Tokyo Bike was designed by London studio Emulsion. More »
Flatform 322 by Toby Horrocks and Kristian Aus
Architect Toby Horrocks and designer Kristian Aus have created this fold-out cardboard shop interior for the State of Design festival in Melbourne. More »
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Erie mom delivers in front seat of car
There are stories of heroic paramedics delivering babies in the most improbable places and in the most trying of circumstances.
This is not one of those stories.
At 9:45 p.m. Monday, after a series of frantic calls and a hectic ride along the Bayfront Parkway, Sarah Schaefer safely delivered her son in the front seat of her car -- by herself.
"I really didn't do anything," said Schaefer, 35. "It just happened on its own."
Schaefer started feeling contractions at about noon Monday, but wanted to wait before heading to the hospital. Her first delivery, with now 21-month-old daughter Ava, had taken 27 hours, and she wanted to be at home and comfortable for as long as possible.
By 9:15 p.m., after she and husband Mark Schaefer had put Ava to bed, the contractions had grown more frequent. By 9:30 p.m., she knew they needed to head to the hospital.
"It was intense," Sarah Schaefer said.
The couple couldn't reach Sarah Schaefer's parents. Finally they reached her brother, who got in touch with his wife at home. The couple live a block away from the Schaefers in Erie's Frontier neighborhood.
After she arrived to watch Ava, the Schaefers sped to the hospital.
"On the drive over, she was just screaming as hard as she could," said Mark Schaefer, 41.
He pulled into the driveway in front of UPMC Hamot Women's Hospital and ran inside.
Before he came back out -- and just minutes after her water had broken in the car -- his wife had given birth to a healthy 6-pound, 3-ounce baby boy in the car.
"The first thing I heard before I saw anything was a baby crying," he said.
Sarah Schaefer remembers sweeping her finger through the baby's mouth to clear his airway before hospital staff quickly arrived to take the mom and baby inside.
"I was kind of in shock," she said.
The couple were still deciding Tuesday afternoon what to name the latest addition to the family. But they do have a piece of advice.
"We advocate getting to the hospital in time," Sarah Schaefer said and laughed.
ERICA ERWIN can be reached at 870-1846 or by e-mail. Follow her on Twitter at twitter.com/ETNerwin.


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Providing Help and Creating Hope. Serving People of All Faiths in 102 Communities since 1920.
Catholic Charities News
SAVE THE DATE 11th Annual Help & Hope Breakfast
Please join us on Friday, December 9th, at the Hartford Marriott Downtown for our eleventh annual Help & Hope Breakfast. Doors will open at 7:00 AM for coffee and networking. The event begins at 7:30 AM and ends promptly at 9:00 AM. All proceeds will benefit Catholic Charities programs for children in need throughout Hartford, Litchfield and New Haven Counties. Webster Bank and Saint Francis Hospital and Medical Center will be Presenting Sponsors for this special event. For more information about sponsorship opportunities, please contact Peter O'Donnell at email@example.com or 860-728-2571.
24th Annual Archbishop John F. Whealon Memorial Golf Tournament
TEE OFF TO HELP CHILDREN on September 13, 2016 at Wampanoag Country Club in West Hartford. Santander is the Presenting Sponsor for this annual event to benefit children in need throughout Hartford, Litchfield and New Haven Counties and Todd Piro, NBC Connecticut Anchor, will be our Guest Host.
Download a Golf Brochure     View some of our great auction items! Reserve a Sponsorship Golfer Registration
Statement from Catholic Charities CEO Marek Kukulka re: the Refugee Resettlement Program
For 60 years, Catholic Charities in the Archdiocese of Hartford has administered a nationally recognized resettlement program, helping refugees from all over the world resettle in our communities. It is an undertaking that coincides with its mission, which is to promote the dignity, self-sufficiency and human potential of those in need.


text:
MMA Forum - UFC Forums - UFC Results - MMA Videos (http://www.mmaforum.com/forumindex.php)
- Training & Nutrition (http://www.mmaforum.com/training-nutrition/)
- - lose weight? (http://www.mmaforum.com/training-nutrition/7587-lose-weight.html)
lose weight?
ok so im 6'1 103 Kg
and i want to go down like to 90 for now
so is there any plan i should on
and what to eat
Just remember, you must expend more calories than you take in. So increase your cardio and cut down on what you eat each meal.
Why? Why lose weight? your no where near fat in fact for that height you might be considered underweight to being with. Why not lose fat and pack on muscle. say push for a goal like 130 but of muscle?
You'll feel better, have more energy and be like twice as strong as you are now.
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Two people were shot in Toledo late Monday and early today in two apparently unrelated incidents, authorities said. Crishawn Brown, 18, of Toledo, was shot about 10:05 p.m. in a parking lot in the 2000 block of Dorr Street in the central city,
The cards are meant as a way to show a person's true identity.
Law enforcement officials will discuss skimmers, the fraudulent electronic devices that can steal private credit-card information.
Total number shot up to 130 this year.
Defendant apologizes to officers.
Family seeks answers; disappearance, death unsolved.
Hundreds take part in event at home of 180th Fighter Wing.
Man's vehicle struck two others and rolled over several times.
A driver gestures to his truck, which was totaled in a two-vehicle accident on the corner of Osage and Dussel drives in Maumee on Sunday.
Blaze began with man smoking while on home oxygen.


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Embassy 9" Accent Plate by Lenox
Like other pieces in the Embassy dinnerware collection, the Embassy Accent Plate is lavished with 24 karat gold. Unlike Embassy's solid red bands, however, this plate features a rich red waffle motif.
- Crafted of Lenox ivory fine china accented with 24 karat gold
- Dishwasher safe
- Made in USA
- Diameter: 9"
$58.00 $39.95
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Hi everybody, I found this plant in my garden (Cairo, Egypt) and I do not know what it is. It has a creeping habit, its leave have a verbena scent. I first thought of a Kalanchoe.
Thank you for your help to identify it!
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When Late Night Was Polite
Carson's former head writer on how Johnny rose above the fray
With the talk-show food fights dominating much of the news coverage, it may be instructive to consider how Johnny Carson might have handled their dilemma.
For years, a regular visitor to the Carson couch was Joan Rivers. Johnny was her dream straight man, and liked Joan so much that in September 1983 he installed her as his exclusive guest host. Of Johnny's 15 weeks off, Joan hosted nine. The remaining six were "Best of Carson."
On May 6, 1986, following a week pinch-hitting for the man who nurtured her, Ms. Rivers held a press conference with Fox's Barry Diller to announce that she'd signed a deal to host her own late-night series for Fox.
Mr. Carson felt sucker-punched. The week prior to her bombshell, she had guest-hosted as usual and plugged her coming nightclub appearances.
Part of Johnny's daily "Tonight Show" ritual was a morning phone call from his home to me at the office to discuss the comedy material that would follow his monologue. I hadn't yet heard the news about Joan when I took his call.
"So Ray, what do you think about Miss Rivers?" he asked.
He explained what she had done and said, "Not a nice lady." I suggested he'd be better off taking the high road and not getting baited into an on-air monologue feud. He agreed.
"I'm not gonna get into a pissing contest with her," he said.
"The Tonight Show" scrambled. Garry Shandling was tapped to replace Joan for her next two weeks of guest-hosting chores and Jay Leno would fill in the following two.
In my subsequent meetings with Mr. Carson, he never lost his cool about what had happened with Ms. Rivers. He simply expressed disappointment.
He was also charitable toward his other late-night rivals. One night, a guest made a disparaging on-air comment about Dick Cavett, then opposite Johnny on ABC. After his Burbank taping, Johnny phoned Mr. Cavett in New York, hours before the remark would air on the East Coast. He gave Dick a heads-up apology for what someone else had said. I never heard him utter publicly or privately an unkind word about his many competitors.
Today's late-night landscape is more mean-spirited. Jay Leno did give a faint-praise shout-out to Conan O'Brien. But Jay's story that NBC was the sole player behind all the machinations from the get-go didn't ring true. It was reminiscent of the time he blamed his former executive producer for undermining Mr. Carson and David Letterman. Like the night when he took over "The Tonight Show" in 1992 and failed to mention the man who preceded him, Johnny Carson.
It's unseemly to watch multimillionaires airing their mistreatment by NBC as monologue fodder, sniping at each other, especially given the coverage from Haiti. Since the on-air feuds have surfaced, the principals' ratings have increased and spilled over to widely viewed clips on YouTube. Sometimes we just can't help ourselves from peeking at their in-fighting. But ultimately it becomes tedious and we go back to our lives.
Once Mr. Leno Jay-walks back to 11:35, he may be able to recover his fan base, but he's tarnished. He has suffered body blows from Jimmy Kimmel. David Letterman has savaged his longtime nemesis, too. Jay had become an irresistible target. He misplaced his blue-collar, Springsteen persona when he pulled "The Tonight Show" desk and chair out from under Conan. Jay could once again best Dave Letterman, but his reputation as the humble, regular guy has dimmed.
Johnny Carson played in pain through divorces and depositions, deaths and tabloid whoppers—without whining. Measure an athlete by how he plays hurt. Mr. Carson's late-night successors consider him the gold standard, the template for how it's done. If Johnny were still around, I can envision him whispering in their ears: "Guys, come on. 'Host up!' "
—Raymond Siller was a staff writer for Johnny Carson in New York in 1969, and in Los Angeles from 1974 through 1988—the last 12 of those years as head writer.
- Find television listings at LocateTV.


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- author |
- Henry William Chesbrough
- year published |
- 2005
Publisher's Weekly | The great corporate research departments at companies like Bell Labs, IBM and Xerox were once the motor of American industry. But that may be changing, according to this probing academic study of corporate technological innovation.
Chesbrough, an assistant professor at the Harvard Business School, argues that the old "closed innovation" model — vertically integrated research and development departments that develop technology in-house for the sole… read more


text:
Rolling Back the YearsToday
Timeless Theatre Company present a colourful rollercoaster ride of nostalgia at The Core Theatre Solihull
Dawns Jitterbug Comes To SolihullToday
DAWN'S JITTERBUG! Teaching East Coast Swing, Jitterbug, 40's Jive Intermediates Charleston, Strolls & Triple Step Regular venues Birmingham & Solihull Private lessons/Hen Parties/Birthday Parties
Karaoke Wednesdays at Walkabout Bar Solihull28/09/2016
The Newest Karaoke Night in Solihull Every Wednesday
Late Night Opening at MotorServ UK29/09/2016
Late Night Thursdays! At Motor Serv - UK Solihull
The Ronnie Scott's Story29/09/2016
Presented by The Ronnie Scott's All Stars Quintet - Thurs 29 Sep at The Core Theatre Solihull
Slip into Slippers for Age UK Solihull30/09/2016
Slip into Slippers for International Older People's Day - wear your slippers to work or school and make £1.00 donation to Age UK Solihull
Networking in Slippers!30/09/2016
Age UK Solihull invite you to this networking event with a difference at The Corus Hotel on Fri 30 September 2016, 08:30 – 10:30 Wearing slippers is a great ice-breaker!
The BIG Taste 201630/09/2016
The Annual BIG Taste is back for the 6th year running, and it's going to be better than ever.
Family Friday every Friday at Silver Blades Solihull30/09/2016
Ice Skating Fun for all the Family At Silver Blades Solihull Ice Rink
An Evening With The Blues Brothers30/09/2016
Get down and boogie as you listen, sing, and dance the evening away at Hogarths Hotel & Restaurant


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Biomaterials (v.29, #18)
Editorial board (IFC).
The role of cerium redox state in the SOD mimetic activity of nanoceria by Eric G. Heckert; Ajay S. Karakoti; Sudipta Seal; William T. Self (2705-2709).
Cerium oxide nanoparticles (nanoceria) have recently been shown to protect cells against oxidative stress in both cell culture and animal models. Nanoceria has been shown to exhibit superoxide dismutase (SOD) activity using a ferricytochrome C assay, and this mimetic activity that has been postulated to be responsible for cellular protection by nanoceria. The nature of nanoceria's antioxidant properties, specifically what physical characteristics make nanoceria effective at scavenging superoxide anion, is poorly understood. In this study electron paramagnetic resonance (EPR) analysis confirms the reactivity of nanoceria as an SOD mimetic. X-ray photoelectron spectroscopy (XPS) and UV–visible analyses of nanoceria treated with hydrogen peroxide demonstrate that a decrease in the Ce 3+/4+ ratio correlates directly with a loss of SOD mimetic activity. These results strongly suggest that the surface oxidation state of nanoceria plays an integral role in the SOD mimetic activity of nanoceria and that ability of nanoceria to scavenge superoxide is directly related to cerium(III) concentrations at the surface of the particle.
Keywords: Free radical; Nanoparticle; Superoxide; Surface analysis; Cerium oxide;
Favourable influence of hydrophobic surfaces on protein structure in porous organically-modified silica glasses by Bouzid Menaa; Mar Herrero; Vicente Rives; Mayya Lavrenko; Daryl K. Eggers (2710-2718).
Organically-modified siloxanes were used as host materials to examine the influence of surface chemistry on protein conformation in a crowded environment. The sol–gel materials were prepared from tetramethoxysilane and a series of monosubstituted alkoxysilanes, RSi(OR′)3, featuring alkyl groups of increasing chain length in the R-position. Using circular dichroism spectroscopy in the far-UV region, apomyoglobin was found to transit from an unfolded state to a native-like helical state as the content of the hydrophobic precursor increased from 0 to 15%. At a fixed molar content of 5% RSi(OR′)3, the helical structure of apomyoglobin increased with the chain length of the R-group, i.e. methyl < ethyl < n-propyl < n-butyl < n-hexyl. This trend also was observed for the tertiary structure of ribonuclease A, suggesting that protein folding and biological activity are sensitive to the hydrophilic/hydrophobic balance of neighboring surfaces. The observed changes in protein structure did not correlate with total surface area or the average pore size of the modified glasses, but scanning electron microscopy images revealed an interesting relationship between surface morphology and alkyl chain length. The unexpected benefit of incorporating a low content of hydrophobic groups into a hydrophilic surface may lead to materials with improved biocompatibility for use in biosensors and implanted devices.
Keywords: Sol–gel encapsulation; Circular dichroism; Hydrophobicity; Protein stability; Molecular confinement; Surface morphology;
The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite by Takatoshi Okuda; Koji Ioku; Ikuho Yonezawa; Hideyuki Minagi; Yoshinori Gonda; Giichiro Kawachi; Masanobu Kamitakahara; Yasuaki Shibata; Hisashi Murayama; Hisashi Kurosawa; Tohru Ikeda (2719-2728).
A newly developed calcium-deficient hydroxyapatite composed of rod-shaped particles synthesized by the hydrothermal method (HHA) and stoichiometric hydroxyapatite (SHA) synthesized by the sintering method was used for in vivo implantation and in vitro culture systems to compare these biological responses. In the rabbit femur, implanted HHA was slowly resorbed and about 80% of the implant remained 24 weeks after implantation; however, up to 72 weeks after implantation, most of the implanted HHA was resorbed. The implanted SHA was unresorbed throughout the experimental period, but degradation by the invasion of newly formed bone was seen at 72 weeks after implantation. Bone histomorphometry showed that the volume of newly formed bone and the number of osteoclasts in the implanted region were significantly higher in HHA than in SHA 24 weeks after implantation. In vitro culture of C2C12 cells with the induction of osteoblastic phenotypes using recombinant bone morphogenetic protein-2 showed similar cell density and the induction of alkaline phosphatase activity between the cells on HHA and SHA discs. In vitro osteoclastogenesis of HHA and SHA discs using bone marrow macrophages and recombinant receptor activator of nuclear factor-κB ligand showed higher TRAP activity of osteoclasts cultured on HHA discs. These results showed that slow biodegradability did not always correlate to final replaceability in bone tissue, and suggested that the activity of osteoclasts correlated to the bone-forming activity of osteoblasts.
Keywords: Bone substitute; Biodegradation; Bone graft; Cell culture; Osteoclast;
The influence of an in vitro generated bone-like extracellular matrix on osteoblastic gene expression of marrow stromal cells by Quynh P. Pham; F. Kurtis Kasper; L. Scott Baggett; Robert M. Raphael; John A. Jansen; Antonios G. Mikos (2729-2739).
The function and development of cells rely heavily on the signaling interactions with the surrounding extracellular matrix (ECM). Therefore, a tissue engineering scaffold should mimic native ECM to recreate the in vivo environment. Previously, we have shown that an in vitro generated ECM secreted by cultured cells enhances the mineralized matrix deposition of marrow stromal cells (MSCs). In this study, MSC expression of 45 bone-related genes using real-time reverse transcriptase polymerase chain reaction (RT-PCR) was determined. Upregulation of osteoblastic markers such as collagen type I, matrix extracellular phosphoglycoprotein with ASARM motif, parathyroid hormone receptor, and osteocalcin, indicated that the MSCs on plain titanium scaffolds differentiated down the osteoblastic lineage and deposited a mineralized matrix on day 12. Significant mineralized matrix deposition was observed as early as day 4 on ECM-containing scaffolds and was associated with the enhancement in expression of a subset of osteoblast-specific genes that included a 2-fold increase in osteopontin expression at day 1 and a 6.5-fold increase in osteocalcin expression at day 4 as well as downregulation of chondrogenic gene markers. These results were attributed to the cellular interactions with growth factors and matrix molecules that are likely present in the in vitro generated ECM since the genes for insulin-like growth factor 1, insulin-like growth factor 2, vascular endothelial growth factor, dentin matrix protein, collagen type IV, cartilage oligomeric protein, and matrix metalloproteinase 13 were significantly upregulated during ECM construct generation. Overall, the data demonstrate that modulation of MSC differentiation occurs at the transcriptional level and gene expression of bone-related proteins is differentially regulated by the ECM. This study presents enormous implications for tissue engineering strategies, as it demonstrates that modification of a biomaterial with an in vitro generated ECM containing cell-generated bioactive signaling molecules can effectively direct gene expression and differentiation of seeded progenitor cell populations.
Keywords: Extracellular matrix; Gene expression; Growth factors; Osteoblast; Scaffold;
Influence of cyclic strain and decorin deficiency on 3D cellularized collagen matrices by Zannatul Ferdous; Luis D. Lazaro; Renato V. Iozzo; Magnus Höök; Kathryn J. Grande-Allen (2740-2748).
Cyclic strain evokes the expression of the small leucine-rich proteoglycans decorin and biglycan in 2D cultures and native tissues. However, strain-dependent expression of these proteoglycans has not been demonstrated in engineered tissues. We hypothesized that the absence of decorin may compromise the effect of cyclic strain on the development of engineered tissues. Thus, we investigated the contribution of decorin to tissue organization in cyclically strained collagen gels relative to statically cultured controls. Decorin null (Dcn −/−) and wild-type murine embryonic fibroblasts were seeded within collagen gels and mechanically conditioned using a Flexcell® Tissue Train® culture system. After 8 days, the cyclically strained samples demonstrated greater collagen fibril density, proteoglycan content, and material strength for both cell types. On the other hand, increases in cell density, collagen fibril diameter, and biglycan expression were observed only in the cyclically strained gels seeded with Dcn −/− cells. Although cyclic strain caused an elevation in proteoglycan expression regardless of cell type, the type of proteoglycan differed between groups: the Dcn −/− cell-seeded gels produced an excess of biglycan not found in the wild-type controls. These results suggest that decorin-mediated tissue organization is strongly dependent upon tissue type and mechanical environment.
Keywords: Decorin; Collagen; Tissue engineering; Cyclic strain; Proteoglycan; Biglycan;
The formation of pores in the basal lamina of regenerated renal tubules by Annette Blattmann; Lucia Denk; Raimund Strehl; Hayo Castrop; Will W. Minuth (2749-2756).
Little information is available concerning the generation of renal tubules, but this information is urgently needed in regenerative medicine for the future treatment of acute and chronic renal failures. Of major interests are the integration of stem/progenitor cells, the cellular development and the tubular growth in a spatial environment. In this regard, we investigated the basal aspect of renal tubules generated at the interphase of an artificial interstitium. Stem/progenitor cells derived from neonatal rabbit kidney were mounted inside a specific tissue holder and covered by layers of polyester fleece. The tissue was then kept in a perfusion culture container for 13 days in chemically defined IMDM containing aldosterone (1 × 10−7 m) as a tubulogenic factor. The spatial development of tubules was registered on whole-mount specimens and on cryo-sections labeled with soybean agglutinin (SBA) and tissue-specific antibodies indicating that collecting duct tubules were developed. Scanning electron microscopy (SEM) revealed that the generated tubules were completely covered by a basal lamina. Most interestingly, the matrix was not consistently composed, but exhibited three categories of pores. The most frequently found pore type had an apparent diameter of 133 ± 26 nm followed by a medium-sized pore type of 317 ± 35 nm. Another category of pores with a diameter of 605 ± 101 nm was rather rarely found. All of the pores were evenly distributed and not restricted to particular sites. The newly detected pores are not related to culture artifacts, since they were also detected in collecting duct tubules of the neonatal rabbit kidney. It remains to be evaluated whether these pores support physiological transport functions or if they indicate the site where extracellular matrix proteins are inserted into newly synthesized basal lamina.
Keywords: Tissue engineering; Perfusion culture; Kidney; Collecting duct; Tubule; Basal lamina;
Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: Systematic modulation of a synthetic cell-responsive PEG-hydrogel by Thomas P. Kraehenbuehl; Prisca Zammaretti; André J. Van der Vlies; Ronald G. Schoenmakers; Matthias P. Lutolf; Marisa E. Jaconi; Jeffrey A. Hubbell (2757-2766).
We show that synthetic three-dimensional (3D) matrix metalloproteinase (MMP)-sensitive poly(ethylene glycol) (PEG)-based hydrogels can direct differentiation of pluripotent cardioprogenitors, using P19 embryonal carcinoma (EC) cells as a model, along a cardiac lineage in vitro. In order to systematically probe 3D matrix effects on P19 EC differentiation, matrix elasticity, MMP-sensitivity and the concentration of a matrix-bound RGDSP peptide were modulated. Soft matrices (E = 322 ± 64.2 Pa, stoichiometric ratio: 0.8), mimicking the elasticity of embryonic cardiac tissue, increased the fraction of cells expressing the early cardiac transcription factor Nkx2.5 around 2-fold compared to embryoid bodies (EB) in suspension. In contrast, stiffer matrices (E = 4036 ± 419.6 Pa, stoichiometric ratio: 1.2) decreased the number of Nkx2.5-positive cells significantly. Further indicators of cardiac maturation were promoted by ligation of integrins relevant in early cardiac development (α5β1, αvβ3) by the RGDSP ligand in combination with the MMP-sensitivity of the matrix, with a 6-fold increased amount of myosin heavy chain (MHC)-positive cells as compared to EB in suspension. This precisely controlled 3D culture system thus may serve as a potential alternative to natural matrices for engineering cardiac tissue structures for cell culture and potentially therapeutic applications.
Keywords: Extracellular matrix; Biomimetic hydrogel; Poly(ethylene glycol); Cardiac tissue engineering; P19 embryonal carcinoma cells; Stem cells;
Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs by Gheorghe Fundueanu; Marieta Constantin; Paolo Ascenzi (2767-2775).
Most part of pH- and temperature-sensitive microspheres used for the controlled delivery of drugs are not biodegradable. Therefore, the aim of this work is to prepare pH- and temperature-sensitive microspheres from biodegradable and biocompatible natural polymers. Pullulan microspheres were prepared by suspension cross-linking with epichlorohydrin of an aqueous solution of the polymer. In order to confer them temperature sensitivity, poly(N-isopropylacrylamide-co-acrylamide) was grafted onto pullulan microspheres. Then, the pH-sensitive units (–COOH) were introduced by reaction between the remaining –OH groups of the pullulan with succinic anhydride. The grafted pullulan microspheres are more hydrophilic than pullulan microspheres, their swelling degree as well as water regain increase significantly. The thermo-sensitivity of the carboxylated microspheres depends to the number and the ionization form (–COOH/–COO−) of carboxylic groups. At a low exchange capacity (0.35 meq/g), microspheres are thermo-sensitive both in the protonated and deprotonated form of –COOH groups. At a higher exchange capacity (2.25 meq/g), microspheres are almost unswellable in the protonated form and swell extensively in the ionized form (up to 28 times than their dried form) loosing in a great extent the thermo-sensitive properties. In isotonic phosphate buffer pH = 7.4, both thermo-sensitive and pH/thermo-sensitive microspheres possess a phase transition temperature close to that of the human body temperature. Loading and release profiles of lysozyme, taken as a molecular model system, were investigated.
Keywords: Intelligent microspheres; pH/thermo-responsive copolymers; Pullulan; Lower critical solution temperature; Drug delivery;
Glutathione-mediated release of functional plasmid DNA from positively charged quantum dots by Dan Li; Gaiping Li; Weiwei Guo; Peicai Li; Erkang Wang; Jin Wang (2776-2782).
DNA was efficiently bound to water-soluble positively charged CdTe quantum dots (QDs) through complementary electrostatic interaction. These QDs–DNA complexes were disrupted and DNA was released by glutathione (GSH) at intracellular concentrations. Interestingly, there was almost no detectable DNA released by extracellular concentration of GSH. The formation of QDs–DNA complexes and GSH-mediated DNA release from the complexes were confirmed by dye displacement assay, electrophoretic mobility shift assay (EMSA), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) experiments. The released DNA retained transcriptional activity and expressed enhanced green fluorescent protein (EGFP) after being transfected into HEK 293 cells. The transfection efficiency measured by flow cytometry (FCM) was comparable with the positive control. The obvious difference of GSH concentration in nature between the intra- and extracellular environments as well as the GSH concentration-dependent triggered release suggests potential applications of these positively QDs in selective unpacking of payload in living cells in a visible manner.
Keywords: QDs; Glutathione; Plasmid DNA; Controlled release;
Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine) by David N. Nguyen; Shyam S. Raghavan; Lauren M. Tashima; Elizabeth C. Lin; Stephen J. Fredette; Robert S. Langer; Chun Wang (2783-2793).
Poly(orthoester) (POE) microspheres have been previously shown to possess certain advantages for the in vivo delivery of DNA vaccines. In particular, timing of DNA release from POE microspheres in response to acidic phagosomal pH was shown to be an important factor in determining immunogenicity, which was hypothesized to be linked to the natural progression of antigen-presenting cell uptake, transfection, maturation, and antigen presentation. Here we report in vitro characterization of the enhanced efficacy of POE microspheres by blending poly(ethylenimine) (PEI), a well-characterized cationic transfection agent, into the POE matrix. Blending of a tiny amount of PEI (approximately 0.04 wt%) with POE caused large alterations in POE microsphere properties. PEI provided greater control over the rate of pH-triggered DNA release by doubling the total release time of plasmid DNA and enhanced gene transfection efficiency of the microspheres up to 50-fold without any significant cytotoxicity. Confocal microscopy results of labeled PEI and DNA plasmids revealed that PEI caused a surface-localizing distribution of DNA and PEI within the POE microsphere as well as focal co-localization of PEI with DNA. We provide evidence that upon degradation, the microspheres of POE–PEI blends released electrostatic complexes of DNA and PEI, which are responsible for the enhanced gene transfection. Furthermore, blending PEI into the POE microsphere induced 50–60% greater phenotypic maturation and activation of bone marrow-derived dendritic cells in vitro, judged by the up-regulation of co-stimulatory markers on the cell surface. Physically blending PEI with POE is a simple approach for modulating the properties of biodegradable microspheres in terms of gene transfection efficiency and DNA release kinetics. Combined with the ability to induce maturation of antigen-presenting cells, POE–PEI blended microspheres may be excellent carriers for DNA vaccines.
Keywords: Polyorthoester; Microsphere; Immune response; Controlled drug release; Gene therapy;
A sandwich structured SiO2/cytochrome c/SiO2 on a boron-doped diamond film electrode as an electrochemical nitrite biosensor by Rong Geng; Guohua Zhao; Meichuan Liu; Mingfang Li (2794-2801).
A novel sandwich structured SiO2 gel/cytochrome c (Cyt c)/SiO2 gel was designed and constructed on conductive boron-doped diamond (BDD) film substrate. A SiO2 gel membrane was first in situ deposited on the pretreated positive charged H-terminated BDD electrode with a simple and artful surface vapor sol–gel method. Cyt c was subsequently immobilized onto the SiO2 membranes by electrostatic attraction, followed by another SiO2 gel layer in situ depositing on it. The SiO2 interlayer was conceived to play an important role in the resultant sandwich structured SiO2/Cyt c/SiO2/BDD electrode as a selective "semi-open" medium, which guaranteed the immobilized Cyt c to maintain high stability and perform good electrochemistry and biocatalysis responses. The bioactivity of Cyt c was well protected and the immobilized biomolecule even didn't denature at extremely high or low pH condition. More attractively, Cyt c in the sandwich structured electrode could be further oxidized into highly reactive Cyt c π-cation by two-step electrochemical oxidation, which could oxidize NO2 − into NO3 − in the solution. A sensitive determination approach of nitrite was accordingly built up based on this biocatalytic oxidative interaction for the first time and a possible mechanism of the interaction was herein proposed.
Keywords: Sandwich structured; Protein; Bioelectrocatalysis; Diamond; Nitrite;
Three-dimensional polymer scaffolds for high throughput cell-based assay systems by Ke Cheng; Yinzhi Lai; William S. Kisaalita (2802-2812).
Many whole cell-based assays in use today rely on flat, two-dimensional (2D) glass or plastic substrates that may not produce results characteristic of in vivo conditions. In this study, a three-dimensional (3D) cell-based assay platform was established by integrating 3D synthetic polymer scaffolds with standard cell culture dishes and multi-well plates. This technology can be used to feasibly modify any traditional 2D cell-based assay vessels for 3D cell-based assay with currently used high throughput screening (HTS) systems. We examined neural stem (NS) cells' growth profile, morphology, cell–matrix interaction, gene expression and voltage gated calcium channel (VGCC) functionality of this novel 3D assay platform. Our results showed that unlike the NS cells cultured on traditional 2D planar surfaces, cells in 3D scaffolds are more physiologically relevant with respect to in vivo characteristics exhibited by in-vivo surrogates such as neural spheres. This new biomimetic cell-based assay platform may provide a broadly applicable 3D cell-based system for use in drug discovery programs and other research fields.
Keywords: Biomimetic material; ECM; Cell culture; Scaffold; Stem cell;
A synthetic amyloid lawn system for high-throughput analysis of amyloid toxicity and drug screening by Koyeli Girigoswami; Sook Hee Ku; Jungki Ryu; Chan Beum Park (2813-2819).
Amyloid-β (Aβ) is the major constituent of senile plaques in the brains of Alzheimer's disease patients. In order to develop an efficient in vitro system for studying the interaction of cells with Aβ aggregates, we have prepared a synthetic amyloid lawn by immobilizing Aβ peptides over a functionalized glass surface and subsequently incubating the template in a fresh Aβ solution. On the top of different types of amyloid lawns (e.g. monomeric, oligomeric, and fibrillar), we cultivated PC12 cells, creating physical contacts between the cells and the lawns. Results indicated that cell viability was differentially affected when grown atop different Aβ lawns while cells were well adhered onto the surface of these Aβ lawns. The mode of cell death by Aβ lawn was confirmed to be apoptotic rather than necrotic, showing that cells undergo suicide by just contact with Aβ lawn. While conventional 'solution-based' methods for testing amyloid toxicity suffer from problems such as lot-to-lot variations, continued fibrillation, and heterogeneous population of aggregates, our 'surface-based' lawn system is suitable for high-throughput analysis of amyloid toxicity, which may enable high-throughput screening of potential drug candidates for treating amyloid diseases with the goal of reducing the cell death on the lawn.
Keywords: Self-assembly; Cell viability; Surface modification; Amyloid aggregation;
Identification, recombinant production and structural characterization of four silk proteins from the Asiatic honeybee Apis cerana by Jiahai Shi; Shixiong Lua; Ning Du; Xiangyang Liu; Jianxing Song (2820-2828).
Unlike silkworm and spider silks assembled from very large and repetitive fibrous proteins, the bee and ant silks were recently demonstrated to consist of four small and non-repetitive coiled-coil proteins. The design principle for this silk family remains largely unknown and so far no structural study is available on them in solution. The present study aimed to identify, express and characterize the Asiatic honeybee silk proteins using DLS, CD and NMR spectroscopy. Consequently, (1) four silk proteins are identified, with ∼6, 10, 9 and 8% variations, respectively, from their European honeybee homologs. Strikingly, their recombinant forms can be produced in Escherichia coil with yields of 10–60 mg/l. (2) Despite containing ∼65% coiled-coil sequences, four proteins have very low α-helix (9–27%) but unusually high random coil (45–56%) contents. Surprisingly, β-sheet is also detected in four silk proteins (26–35%), implying the possible presence of β-sheet in the bee and ant silks. (3) Four proteins lacking of the tight tertiary packing appear capable of interacting with each other weakly but this interaction triggers no significant formation of the tight tertiary packing. The study not only implies the promising potential to produce recombinant honeybee silk proteins for the development of various biomaterials; but also provides the first structural insight into the molecular mechanism underlying the formation of the coiled-coil silks.
Keywords: Asiatic honeybee Apis cerana; Silk protein; Coiled-coil; Recombinant biotechnology; Dynamic light scattering; Circular dichroism;


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The spring shows feature debuts at four major brands, prompting reflection on the pace of designer change.
The luxury chain has been battling the luxury malaise.
The city has not lost its sizzle, once again led by Prada and Gucci.
His role will be to champion initiatives to help make it easier for young entrepreneurs, and small businesses, to participate in global trade.
The lifestyle doyenne revealed that she wants to get started 'asap.'
Photographed by Cass Bird and styled by Julia Sarr-Jamois, the campaign was shot in the company's studio in East London.
Hilfiger and Mottola will become advisors to Evine.
The app is more than China's dominant social media and messaging platform. It's also a future leader in cross-border e-commerce and an avenue for brands to personalize interactions with their target audience.
Online luxury sales currently account for only five percent of the domestic luxury market in China, according to a recent report from business intelligence agency L2.
The plus-size business is expanding its product offering, among other initiatives.
A former Levi Strauss executive wants his clothing line to be the ice breaker that pushes people away from their phones and back into the real world.
German online platform planning European launch in 2017.
Ahead of next week's G20 meeting in Hangzhou, Alibaba founder Jack Ma, the city's favorite son, has released a video welcoming world leaders and proposing an "Electronic World Trade Platform."
The company's next subscription box unveils a scarf collaboration with ModCloth, while personalization and FabFitFun's in-house brands also become key focus points for growth.
Mobile phones have eclipsed desktops and laptops as the most popular devices used for online shopping in the country. Meanwhile, WeChat Pay and Alipay payments are the norm.


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Back on the topic, I'm sorry to see KERS coming back this year. FOM go on and on about wanting to keep costs down, and then screw around with things like this. I don't feel like it adds much of anything to the sport. We'll see.
I hope to see Schumi do well. I'd like to think he's got at least one win left in him.
- Mega D
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Member for 11 years, 8 months, and 16 days
Last active Fri, Jul, 22 2011 12:38:15
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Mar 15, 2011 Posted in: Entertainment Archive
Mar 14, 2011Mega D posted a message on White sweeper protection?You don't need an anti-Day of Judgment card. You just need to control yourself when playing out your creatures. After you've played out a couple of threats, look at the board and ask yourself, "If he has a Wrath, would he use it next turn?" If the answer is "yes", you may want to hold back on other creatures. Play out just enough so that he needs to Wrath, and no more.Posted in: Standard Archives
Real anti-Wrath cards are things like Squadron Hawks and Hero of Bladehold when you play them smartly. Playing things like Silence just makes your deck worse.
Mar 11, 2011Mega D posted a message on Two-man Non-Booster draft?Winston drafting is what you're looking for. Here's an article that tells you how to do it.Posted in: Magic General
Mar 2, 2011The last race of the F1 season is November 27. Formula 1 races also take place all over the world, which is a little bit harder to coordinate. If the police and military in Las Vegas were shooting protesting civilians, there's probably a good chance that their race would get postponed, too. Nascar races get canceled for RAIN, for crying out loud. In F1 you just change your tires.Posted in: Entertainment Archive
And it isn't possible to have one of these lap-long side by side battles that you're so enamored with. In F1, you see, the courses have turns. You won't be familiar with those, but they make completing a lap rather more complicated than driving around the inside of a bowl for 400 miles.
Jan 27, 2011Nascar only has so much overtaking and side-by-side racing because they have constant cautions that bunch the field back up, never letting them spread out the way they do in F1. If F1 races had full course cautions every 5 laps, it would look a lot more like Nascar. It would not be an improvement, however, in my opinion.Posted in: Entertainment Archive
Jan 19, 2011Mega D posted a message on Anything blue can't do?Personally, I like seeing a little more bleed between blue and black. It's just my own opinion, but it's always seemed to me that blue and black have much less in common than other allied color pairs.Posted in: New Card Discussion
And, as has been said, these cards are all pretty terrible apart from the tapper/pinger in limited. It's not like they're printing a blue Lightning Bolt or Naturalize. I think it's fine to give the boundaries a little push once in a while. Magic evolves. This isn't anything too drastic.
Jan 19, 2011Mega D posted a message on Should Leeches get Reprinted?Posted in: Magic GeneralQuote from Card Slinger JI figured with Infect decks causing problems in Standard and other formats...
Citation needed. Where are infect decks causing problems? Infect is far from overpowered in standard right now. It's barely even playable.
If it's a problem in EDH, then that's a problem for the EDH designers to figure out. Magic wasn't designed to be played that way, and some things that work fine in real Magic are obviously going to behave differently in casual, player-invented formats. That's not a problem to be solved by printing cards.
Nov 5, 2010Mega D posted a message on why did people hate Coldsnap?The only thing I hated about Coldsnap was that it cut short the time that we could have been drafting more Ravnica/Guildpact/Dissension. From the time the whole color pair "guild" system was announced I couldn't wait until the third set to come out so we could draft the whole thing. Then stinking Coldsnap came out in July stole away two months that we could have been drafting full Ravnica block. One of the best limited formats ever, if not the very best, and it gets prematurely replaced by a pretty poor one.Posted in: Magic General
Aug 18, 2010Mega D posted a message on Coldsnap Sucked Right???The main reason I found Coldsnap annoying was that it cut short the time that we could have been drafting more Ravnica block.Posted in: Magic General
Jun 15, 2010Mega D posted a message on Is it worth the $20 for a...It depends what you want it for. The "semi-random" cards contain a number of staple commons and uncommons like Lightning Bolt, Divination, Doom Blade, Mind Control, and the like. If you already have that stuff covered in your collection, you may not be getting much out of this.Posted in: Magic General
The toolkit is great, in my opinion, for someone who is coming back to the game after being away for a while. With just the contents of this box a person could make one or two decent standard decks that you can play at an FNM or around the kitchen table. Obviously they're not going to be tier-1 competitive decks, but what you can make from this box is going to be stronger and far more focused than a typical pre-con. A good foundation to build on.
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Great Expressions Dental Centers
555 Old Norcross Road, Suite 120
Lawrenceville, Georgia 30045
770-277-9700 Phone
770-277-4064 Fax
- Mon: 8:00am- 5:00pm
- Tue: 8:00am- 5:00pm
- Wed: 8:00am- 5:00pm
- Thu: 8:00am- 5:00pm
- Fri: 8:00am- 5:00pm
- Sat: --
About Great Expressions Dental Centers
Great Expressions Dental Centers provides quality and affordable dental services for the entire family, including general dental care, orthodontics (braces), pedodontics, periodontics, endodontics and oral and maxillofacial surgery.
As one of the largest providers of dental health services, Great Expressions Dental Centers is uniquely able to provide the most technologically advanced dental services at an affordable price and in a comfortable, friendly environment. New patients are always welcome!
Our professional team is highly trained in the latest dental procedures and qualified, to not only maintain your dental health, but also to assist in the prevention of many serious dental and medical illnesses.
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Our Dentists
Dr. Jonathan Chang
Dr. Monira Uddin


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Start to finish: 25 minutes.
Quarter zucchini lengthwise and cut crosswise into 3-inch spears (about ½-inch thick).
Heat broiler; set a rack 4 to 5 inches from heat.
Apply salt and pepper to salmon all over. Arrange on a large rimmed baking sheet. Sprinkle top of fillets with 1 teaspoon of the chili powder. Arrange zucchini around salmon. Sprinkle with remaining 1 teaspoon chili powder and season with salt and pepper.
Broil until fish is opaque throughout and zucchini is tender, 8 to 10 minutes.
Meanwhile, in large skillet, heat oil over high heat. Add corn and garlic and cook, tossing, until corn is tender and beginning to brown, about 5 minutes. Remove from heat; stir in green onions and salsa. Season to taste with salt and pepper.
Place fillets on plates and serve with zucchini and corn mixture. Garnish with lime wedges, if desired.
Note: The corn also is good on its own, without the salsa; increase amount of corn to 3 cups.
Recipe and photo source: Adapted from "Great Food Fast" from the Martha Stewart Kitchens (Potter, 2007, $24.95)
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text: If you have a benefit ride coming up, email email@example.com and we will get it up! Every Thurs. The Fox Bike Night Get Revved up for THE WORLD'S FASTEST BAGGER COMPETITION! ROAD SKULLS V-TWIN PERFORMANCE is on hand with Colorado's Fastest Bagger! Bike Night at Quaker Steak and Lube and Road Skulls V-Twin Performance Cruise up and join us for dinner, drinks and, of course, some classic rock. Quaker Steak & Lube 10392 Reed Street Westminster, CO 80021 (Near Highway 36 & Church Ranch Blvd. ROAD SKULLS V-Twin Performance and Quaker Steak & Lube present the World's Fastest Street Legal Bagger Competition running at the Colorado Mile. • Registration is now open and information can be found on RoadSkulls.com and usmileracing.com • The competition is running from Las Vegas to Denver starting on Sept 1st (like the Gumball run), and then the baggers will race for top speed at the Colorado Mile over labor day weekend. It takes place at Watkins Airport Sept. 2-4.• This competition is not limited to baggers, as prizes will also be handed out to spectators that join the journey from Vegas to Colorado. You can take any motorcycle, car, or truck, as the run from Vegas to Colorado as it is not a race but a ride. • There is over $5000 in cash and prizes to all that participate in this competition, spectators and competitors. AUGUST Event: SALUTE TO AMERICAN VETERAN'S RALLY AUGUST 19-21, CRIPPLE CREEK, CO. http://www.theveteransrally.org/ Event: Colorado Dual Sport Adventures Organization: American Motorcyclist Association Date: Friday, August 12 to Sunday, August 14 Cost: Location: Salida Information: www.coloradodualsport.com/ September Event: Colorado Motomarathon Organization: Motomarathon Association Date: Friday, September 9 through Monday, September 12 Cost: $50 registration Location: Winter Park, Winter Park Resort, 85 Parsenn Road Information: http://www.motomarathon.com/events.html Event: 2nd Annual BID Poker Run Beneficiaries: Fallen bikers and their families Date: Saturday, September 24 Cost: $20 rider, $10 passenger Location: Greeley, Greeley Harley-Davidson, 3010 W. 29th Street Information: http://www.nocobid.com/events.html October Event: AMA Endurocross National Championship Series Organization: American Motorcyc list Association Date: Saturday, October 1 Cost: Location: Denver, National Western Events Center, 4655 Humboldt St. Information: http://motocross.transworld.net/endurocross/


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Saint Margaret's Community Church, Angmering
- About Us
- Find Us
- Contact Us
- Services and Events
- Features and Facilities
- More Info
Welcome to SMCC (St Margaret's Community Church) in Angmering. We are a lively and growing evangelical church for all ages. Whoever you are and whatever your background, we aim to help you encounter God in the fullest way possible this side of heaven. We know that when people come face to face with the living God, lives are transformed and are never the same again. We are excited to be at the heart of God's extraordinary work in the lives of ordinary people.
Our services are informal and cafe style, with refreshments served at the beginning and end. We are proud of our welcome team who will make sure you are put at your ease and made to feel quickly at home.
Most Sundays there are children's groups during the service, except for during 'all-age services' which happen about once a month. Currently the children's groups are "Quest" - for primary school age, "E-motion" - for secondary school age, and crèche for the little ones. The crèche is there as a help to parents and carers but it certainly isn't compulsory -because we know sometimes little ones aren't keen to separate!
We are a sister church to St Margaret's Parish Church
Our aim is to encounter God and to allow Him to transform our lives in wonderful ways as we worship, pray, listen to His word read and preached and, once a month, share in the Lord's supper. We believe all the spiritual gifts mentioned in the Bible are for today and we encourage their appropriate use in our services.
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4. Iowa State 2013 record: 3-9
Last year vs. OU: 48-10, Oklahoma
Why this game is dangerous: Copy and paste from the Kansas breakdown, although this one could be a little tougher. It's all in how you look at it. There's two weeks for the Sooners to prepare for this one, but Baylor – possibly the biggest game of the year – looms in the following week. If new Iowa State offensive coordinator Mark Mangino can find a way to make his offense gel, then the Cyclones could be set for an upset. Players to watch: Best case scenario: Sterling Shepard goes off for double-digit catches, 100-plus yards and multiple scores. Worst case: Shepard only scores once. By this time in the season, all eyes could be on Shepard, a junior out of Oklahoma City. He has a chance to be one of the conference's top pass catchers. Prediction: It's not a stretch to say that a late score helps Oklahoma prevail in this one, but it's also not very likely. The Sooners' defense will be too dominant, especially against a team that could be in shambles on offense. The season's first and only shutout comes in Ames, Iowa – the first since last year's season opener.


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SIZE 2 oz
We are no longer offering Organic Virgin Coconut Oil - Unscented Travel Size by adara. Discover a new favorite or contact our beauty concierge for further assistance.
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Love this product, not too oily but really hydrates. Use in bath or as a hair treatment. Light pretty smell too
I have used coconut oil for years and this is the most pure on the market. Just make sure you keep it someplace warm :)