text:
St. Edmund shuts out Iota
IOTA – For the Iota Bulldogs, the opponent changed Friday night, but result did not.
Thanks to several missed opportunities via fumbles, an interception and penalties, the Bulldogs dropped to 0-2 on the year as the St. Edmund Blue Jays won 34-0 and improved to 1-1.
"Our defense never showed up tonight against their (St. Edmund's) spread offense," said Bulldogs Coach Neal Legé. "It was like our head was in the lights all night.
"[On offense,] every time we got something going positive, we would fumble the ball. We are hurting ourselves. We are not executing our offense the way we need. Defensively, we have been horrible at tackling and we need to get better.
"We have yet to play a full game. We get out there and maybe get tired a little and we just can't seem to string four quarters together. We have to regroup next week and go to Lake Arthur and see what we can do."
The Bulldogs found themselves behind the eight-ball early after an opening drive that looked promising. Iota would march the ball 45 yards down the field in 9 plays, running at will to the St. Edmund 20 yard line. On the 10th play, however, the Bulldogs fumbled the ball and the Blue Jays halted Iota's drive.
It was a swing in momentum to the Blue Jays that the Bulldogs could never regain.
"We marched the ball down and turned it over and then didn't do anything again until the end [of the game] when we finally started moving the ball in the second half," said Legé.
In fact, Iota would commit four turnovers on the night, three in the first half. It was more of the missed opportunities that plagued the Bulldogs all game. Even with six possessions of 11 minutes and 52 seconds in the first half, Iota could not find the end zone or any offensive rhythm after the opening drive falter.
On the other sideline, meanwhile, St. Edmund was dead set on bouncing back from its tough Week One loss to Rayne. And after an opening drive fumble of its own, the Blue Jays would score on five straight possessions between the second and third quarters. In fact, the 28-point second quarter would prove to be the earlier dagger in the game.
"We had a couple of guys get bumped up and were playing some other guys (other than our first team), and it just was too much," said Legé.
Of its 388 total yards of offense, St. Edmund gained 216 of those yards in the second quarter. The quick-paced Blue Jays kept the Bulldogs reeling in the quarter with fast snaps and solid plays running and passing. It seemed there was no defensive answer for the Blue Jays by the Bulldogs Friday night.
"You can't play like that; you can't freelance against that kind of offense," said Legé. "We did get a few stops, but they scored at will."
For the Bulldogs the trouble began with the opening drive turnover but was amplified once the Blue Jays began scoring touchdowns. St. Edmund's first scoring drive was a three play, 56 yard drive that ended with Stone LeJeune scoring on a 54 yard pass from quarterback Drew Brown. Kyle Verdugo's kick gave St. Edmund the 7-0 lead with 10:25 remaining in the second half.
The busy quarter was only beginning for the Blue Jays after St. Edmund forced a punt, marched the ball 68 yards on 12 plays down the field and scored from 5 yards out. This time, however, it was on the ground, courtesy of Brown's five yard run. Verdugo would miss the point after, however, and the score would only be 13-0 in favor of the visiting Blue Jays with 5:03 remaining.
Staring at a two possession deficit, Iota would have to answer fast if it wanted to make Friday's contest a game again. Instead, though, it fumbled again and turned the ball over on the first play from scrimmage. St. Edmund took five plays to travel 53 yards and scored on Brown's 2 yard pass to Chase Dupre. And thanks to Brown's conversion pass to Gibson LaFleur, St. Edmund rocketed up to a 21-0 lead with 3:37 remaining.
St. Edmund would get another possession in the second after the Blue Jays' Dray Veillon hauled in an interception off of Iota's quarterback Timothy Lunson with 1:50 remaining in the half. True to form St. Edmund traveled 39 yards in two plays and scored a touchdown. With 31 seconds remaining, LeJeune pulled in a 6 yard pass from Brown for the six points and Verdugo would add a kick for another point, giving the Blue Jays a 28-0 lead.
Rolling into halftime facing a 28-0 deficit was tough for Iota, but compounding the problem was their inability to stop the Blue Jays and the fact that St. Edmund would start the second half with the ball.
The Blue Jays would begin the second half as they ended the first, crossing the goal line and lighting up the scoreboard. A slower drive than most of its others, nine plays and 59 yards, the Blue Jays scored with 10:09 remaining in the third on a 27 yards pass from Brown to LeJeune.
Unfortunately for Iota, even though the Bulldogs offense finally found some forward progress, it would also not be able to convert two long drives in the half into points, thanks to a failed fourth down conversion and the Bulldogs' fourth turnover, another fumble, on the night. Still, it was finally the offensive positive Iota and its fans spent all night looking for.
"We got in the Power I and said, 'Hey, we're going to run right at these guys,' and we had a lot of success with it," said Legé. "Then we would have that one play that would stop the clock and stop our momentum."
St. Edmund would end the night with six Blue Jays rushing the ball and five catching passes. Leading the way offensively for the victors was Brown who accounted for all five touchdowns, four passing and one rushing. He would finish the night 16-22 with 223 yards and an interception with his four passing touchdowns and 18 carries for 72 yards and a rushing touchdown.
For the Bulldogs, the offensive numbers were far less. Gaining 183 total yards, 18 yards in the air, 165 on the ground. Lunson finished the night 3-6 with 18 yards and an interception. On the ground, Michael Thevis led the Bulldogs with 21 carries for 86 yards, and joining him were Kenny Guillory (15 carries for 46 yards), Nick Sloane (eight carries for 26 yards) and Tyler Prejean (three carries for 7 yards). Bulldogs receivers were Kyle Smith (an 8 yard reception), Tristan Fontenot (a 6 yard reception) and Thevis added a four yard reception.


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Rated 4.7 out of 5 by 2305 reviewers.
Rated 5 out of 5 by SunnyinSC I miss my dog! Ever since giving my Labrador the Comfy Pet Couch as an early Christmas gift, he no longer sleeps on the floor under my desk after breakfast. I now find him happily lounging in his new bed. I suspect I am going to buy another for my home office! December 15, 2011
Rated 5 out of 5 by loveanimals Great dog bed I purchased two beds for different rooms in the house. This is an exceptionally well made bed. The fabric is upholstery quality and should last a long time. The personalized pillow is a nice bonus! My cats and dog love it. I'm very happy with my purchase. December 14, 2011
Rated 5 out of 5 by Sharonf16 Comfy Couch Indeed! I can't speak for my Golden Doodle, Ruby, but I will do my best! The couch showed up earlier than expected...it was a lovely. The personalized pillow also was a very nice touch, though I don't know that Ruby appreciated her little brother (Zac) thinking it was a dog toy. The quality of the bed is excellent and very comfy and we are very pleased. October 24, 2010
Rated 5 out of 5 by CHAMPTOGIE Appropriately Named---& Finally a Comfy Pet Couch! Ihave owned Labrador Retrievers my entire life and this comfy dog bed/couch wins my vote for the best dog bed ever purchased!!! Iniatially, we purchased one comfy pet couch, but had to order a second one, to please both of my Labs. Now, they both are content as can be & sleep ever so peacefully! Ruff,ruff, we love the bolsters.T October 24, 2010
Rated 5 out of 5 by Doglover Got another dog needed a second bed! We bought this bed for our Brittany to get her off our bed. It worked great until we took in a foster Brit. He crawled into her bed the very first night he came and would not let her use it. So we promptly ordered a second one. It arrived in a few days. She is happy, he is happy and we have our bed back... We are VERY happy!!! I would highly recommend this bed, go for one bigger than you think you need so your dog can really stretch out, our guys do! August 16, 2010
Rated 5 out of 5 by Jen Best Pet Bed Ever From the moment the bed came out of the box, our dog has been on it, in every way possible. She loves to rest her head on the ledge of the couch. The product is high quality and looks as though it will last for years. My husband and I sit on our couches and look at each other with a knowing glance, we both are well aware that Kama's bed is much more comfortable. We are quite envious and have to admit, if they made it in our size, we would order one for us as well :o) June 23, 2010
Rated 5 out of 5 by happy gooddog Comfy dog I've been planning on buying my senior golden retriever a new, more supportive bed to ease his weary bones. When I saw the Comfy Pet Couch and read about the quality details, I decided it was time. As soon as I got it out of the package the dog absolutely loved it and seems so much more happy and cozy. The back and side supports mean he doesn't roll off his bed anymore, and he seems fully supported underneath as well. I like that the cover is removable and washable. We like it so well, I bought two more for my son's two dogs. They all have their own attractive, comfortable beds now with their own personalized dogbone pillows. December 24, 2009
Rated 5 out of 5 by MJsor Our Dogs LOVE it! This is the second Comfy couch bed we purchased. The first was 7 years ago and is still in use and in great shape. Our dogs love it. After getting a second dog and some new furniture, we decided to get another bed in a different color to coordinate with our living room. These beds are awesome. They are extremely comfortable ( I've tested it myself). We have 2 female labs about 55 pounds each- and they easily fit together in one extra large bed. Great purchase! September 26, 2016
(58 Questions : 87 Answers)Product Q&A
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Comfy Couch Pet Bed
0 answersIs this bed treated with flame retardants?
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1 week, 4 days ago
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Comfy Couch Pet Bed
0 answersCan you describe the color "sky" in more detail?
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I'm trying to decide between the color sky and platinum in this dog bed. Is the sky color a bright light blue or more of a warm blue/aqua shade?
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Thank you!
1 week, 5 days ago
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Comfy Couch Pet Bed
1 answerCan you get a replacement insert for the pillow in the bed?
Additional information about SueM33 could not be loaded.
My other pet, a cat, peed on the inserted pillow inside the bed. Can I just order a replacement of that pillow?
Length of Ownership: 2-5 years
1 month, 3 weeks ago
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Answer:Thank you for your interest in the Comfy Couch Pet Bed. We are very sorry to hear about your cushion insert. This insert can be hand washed; however, to purchase a new one please contact our customer service at 1-800-263-9850 or email@example.com for further assistance. We sincerely apologize for any inconvenience this may cause.
1 month, 2 weeks ago
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Comfy Couch Pet Bed
1 answerHow can I get the size I need - a SMALL!?
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4 months ago
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Answer:Thank you for your interest in the Comfy Couch Pet Bed. Please select the color you would like and then choose small from the size drop down. The small size is currently available in all colors except the Honeydew color.
3 months, 3 weeks ago
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Comfy Couch Pet Bed
1 answerHow do you wash this bed? Can you throw the entire bottom cushion into the washing machine?
Hastings On Hudson
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I can see that you can unzip most of the cover, but what about the bottom cushion? Can you throw the whole thing into the washing machine?
Length of Ownership: < 1 year
4 months, 1 week ago
Hastings On Hudson
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Answer:Thank you for your interest in the Comfy Couch Pet Bed. For detailed washing instructions please see the "washing instructions" link in the item overview. The inner tufted cushion can be put in the washing machine as is, and the cover comes off the rest of the bed for washing.
4 months, 1 week ago
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Product:36201-Comfy Couch Pet Bed

subset: commoncrawl


text:
Tabulation of Results and Code Determination
Once you have marked the positive reactions on the side of the tube and circled the numbers that are assigned to each of the positive chambers, as indicated in the example below, add the numbers in each bracketed group to get the five-digit code.
The final step is to look up the code number in the Oxi/Ferm Tube II Biocode Manual to determine the genus and species. If confirmatory tests are necessary, the manual will tell you which ones to perform.
In the example below, the code number is 32303. If you look up this number in the Biocode Manual you will find on page 25 that the organism is Pseudomonas aeruginosa. Use this procedure to identify your unknown by applying your results to the blank diagramsprovided.


text:
The Don and Sybil Harrington Cancer Center Comprehensive Breast Center announced Wednesday its participation in a clinical trial with the Computed Tomography Laser Mammography system, a breast imaging device that creates three-dimensional images without the use of breast compression or X-rays.
The Harrington Cancer Center is one of 10 locations in the country - and the only one in Texas - selected as a trial site.
Qualifying criteria for participation in the trial is very specific, said Cinda Courtney, community relations director.
Those qualifying may include women with an abnormality that is likely to be benign or is moderately suspicious for cancer and for which a biopsy is recommended.
Seven or eight women are participating at this time, Courtney said.
Dr. John Coscia, director of clinical breast radiology at the Comprehensive Breast Center, will oversee the project along with the clinical trials department at the Harrington Cancer Center.
© 2016. All Rights Reserved. | Contact Us


text:
Total Votes: 25
Rating: 3.44
Naughty America is a niche network featuring hardcore sex in a number of different genres. Offering more than 20 sites, there's a little something for everyone's taste and every fantasy you could think of is played out in high quality.
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text:
Hard times come upon Wang Lung and his family when flood and drought force them to seek work in the city. The working people riot, breaking into the homes of the rich and forcing them to flee. When Wang Lung shows mercy to one noble and is rewarded, he begins to rise in the world, even as the House of Hwang falls.
©1958 Pearl S. Buck; (P)2007 Blackstone Audio Inc.
"A beautiful, beautiful book. At last we read, in the pages of a novel, of the real people of China." (Saturday Review)
"The Good Earth has style, power, coherence and a pervasive sense of dramatic reality." (New York Times Book Review)
"To read this story of Wang Lung is to be slowly and deeply purified; and when the last page is finished it is as if some significant part of one's own days were over." (Bookman)
Hey Audible, don't raise prices and I promise to buy lots more books.
"Reread and comment as an adult."
The good earth was published in 1931, awarded the Pulitzer Prize in 1932 and probably contributed to the author winning the Nobel Prize in Literature in 1938. While it can be considered a stand-alone work with its satisfying conclusion, it is the first installment in a trilogy. Set in post-imperial, pre-WWII China, it helped foment poor relations with Japan going into that war.
The book is primarily about the rise and fall of one Wang Lung, his family and fortune. The protagonist begins the book as a hard working farmer who later becomes a rather successful business man as he accumulates more and more land (hence, the good earth theme). Wang Lung loves the land above all other things. That love comes with a price, as all farmers know, in the form of adverse weather, drought and famine. The value that Lung puts on the land in the face of starvation, death and despair represents perhaps the central theme of the book.
I read this book as a youngster when the view and position of China in the world was a great deal different than it is today. I read a review of the book just prior to this reading which blasted the book for its collection of racist stereotypes. On this, Andrew Nathan in Foreign Affairs writes that in his view, Buck delves deeply into the lives of the Chinese poor and opposed "religious fundamentalism, racial prejudice, gender oppression, sexual repression, and discrimination against the disabled." I don't think that we can criticize a book for telling a story about that way things once were and that seems to be the focus of much of the criticism. Further, I think that the book speaks more to who we are as human beings than the Chinese as a race. Apparently the whole notion of race in China is a new one. Chinese intellectuals translated "race" as "zhong zu" (种族) a combination of the word for "seed" (种 or zhong) and an old Chinese term (族 or zu) used to describe the lineage of patrilineal extended families. What a coincidence that is: a book about the earth where seeds are placed and the male-centric families that tend them. Does that make the book racist? Me thinks not.
Now about that rating. For a book that brought its author the Pulitzer and Nobel Prizes, it's hard not to give the book top ratings. Would not less than the highest rating say more about the reviewer than the book? But sometimes we must be bold. Many of us read this book as YAs and, especially because of its simplicity, it fits that billet well. As an adult, however, I look for more layers, depth and complexity in my reads. Not that simple isn't good. For me too, simple can put a book over the top. This was just not one of them.
This is a fantastic story, and it's made even better by a great narrator. One of the best audiobooks I've ever listened to.
Enjoyed this book very much. Excellent narrater and the story kept me interested every step of the way. I would recommend this book highly. Very excellent!
Retired CFO, Army wife, Mom of five, Grandma of six, two sons who served in combat, love to read books that reflect my values and faith, love mysteries, historical, military stories, and books that don't waste my time . . . if it doesn't have an ending that was worth the wait, I'm not a happy camper.
"From the earth we came, and to it we will return"
Listening to this book, now, as I near 60 years old, is such a different experience than reading it in high school in the early 70s. When one is very young, one THINKS that one may be wise, when one is old, if one is blessed, one KNOWS better. The Good Earth is written very simply, but it's far from simple. My heart kept begging Wang Lung to be MORE than his wayward soul . . . to stay true to the good earth . . . to love what is pure . . . to be who he was as a young man. The age old proverbs of men and wealth seem to hold true in all societies. The Good Earth should still be on the reading lists for middle/high school students, along with discussion groups and essays. For there is still much to be gleened from it's pages.
"A Good Read"
I thoroughly enjoyed listening to this audiobook narrated by Anthony Heald. He could very well become a favorite of mine. I was surprised when I learned he was Dr Chilton from Silence of the Lambs. He didn't just read the book, but added inflection to each word.
I read The Good Earth as a requirement when I went to school but didn't remember a thing about it. It was a new and pleasant discovery to read it again.
The book is a rich portrait of culture of the Chinese people. It followed the life of Wang Lung, a poor farmer from working his land and the good life it brought him. It described times of abject poverty and near starvation to wealth and prestige. The story demonstrates how money and wealth can make one forget his/her humble beginnings. It also reflects on the struggle to pass on one's morals and ethics to children.
While I enjoyed this first book in a trilogy, I don't think I will read the other two - Sons and A House Divided. I was engaged with Wang Lung's life but never cared enough about his children to continue on with their stories. But, you never know. I could change my mind.
"Didn't love it"
I'll admit this is well written and the narration is good but about a quarter of the way through I started to really dislike the main character. I listened all the way through and liked him less and less. By the end I was glad to be done with him. An interesting look a pre-communist China but I wouldn't listen to it again.
"Excellent narrator"
Really enjoyed this book and most particularly Anthony Heald's narration. Highly recommended.
"Perhaps the Pulitzer award was politically driven"
Although the craftsmanship of the author was excellent, I was left feeling entirely underwhelmed and even a little empty after listening to this work. There was no deep character development and at that, the characters all seemed simple-minded and even base - quasi animal-like. And perhaps that was the message, that we are all just simple, base, primary needs driven creatures. Having said this, I actually doubt that Buck was trying to make that the main point of the work. And so, was the main thrust that the land is virtuous in some way? If that was her point, then she fell short of explaining why.
I believe there's a chance that this work rose to its Pulitzer prize winning status due to political/sociological events going on at the time, i.e., the depression and class struggles. I doubt it's an accident that this work, extolling the virtues of farmers and portraying the wealthy as entirely negative entities, sold well during the 30's and ultimately was chosen in 1938 to win the Pulitzer.
Anyway, I would like to say that the narration was EXCELLENT! Bravo to Anthony Heald!
"A book of it's times but well performed"
I've been working my way through some of Western culture's "classic" literature and have enjoyed many of them. Some I disliked so much I didn't finish them. I did enjoy this performance, and I enjoyed many aspects of the book. I did struggle with a general dislike of pretty much every character however. I kept waiting for the lead character to grow and change but he did not. I'm guessing it's a combination of cultural differences and literary tastes from the early part of the 20th century. I didn't like any characters in the Great Gatsby either and certainly there isn't anyone likeable in Atlas Shrugged. Having listened to this book soon after the Grapes of Wrath, it was difficult not to compare the two, with the Grapes of Wrath being the clear winner. Still, I am glad I made the effort. The narration is very good and I'll be looking for other books done by this narrator.
I love learning, teaching, and exploring!
"Start of a trilogy"
I did not realize that this book was part of a trilogy. This book was a little bit slow to get into but it unfolded to become a lovely story about a man throughout transformations in his life. The author is very good at describing pivotal events in the life of the main character. It was a memorable story and an enjoyable read although I haven`t yet decided if I would like to read the next books.
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text:
Home > Eyeglasses > Ermenegildo Zegna > EZ5044 (056)
EZ 5044 is available in 6 additional attractive styles
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Size and availability
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Free outbound and return shipping
30-day money-back guarantee
Low prices
EZ5044/056 Eyewear
The term "visual aid" is unsuitable for EZ5044. This is an accessory that ushers in a new you, emphasizing your clear view on fashion. The EZ5044 is brand new on the market in 2016, with this eyewear you are at the cutting-edge of trends. The EZ5044 is available in the Edel-Optics online shop in other styles from Ermenegildo Zegna collections 2015 and 2016.
The frame is specially designed for men. Sporting clear lines, New School Cool meets traditional quality. Wearing full rim eyewear, you make it unmistakably clear that you are going the whole hog. The square frame is a classical shape, highlighting the straightforwardness of the personality. Plastic is a very lightweight and flexible material. This ensures a long life and a high level of comfort. Havana is a particularly warm "spotted" shade of brown. Eyeglasses in this style lend softness to your facial features and suit any type of skin.
With the help of our digital dispensing optician, your prescription lenses can be configured according to your own requirements. Anti-reflective and cleaning coatings, antistatic and lotus effect are included as standard for plastic lenses.
Even if this Ermenegildo Zegna is presently not in stock, it is worth ordering now, because the current price can't be beaten. And because Edel-Optics is a paradise for bargain hunters, you can get this top model at an incredibly low price. What is labelled as "in the sale" at other online shops, is for us "all-day-everyday" prices.
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Montego Restaurant Bar & Catering
San Juan Capistrano, CA 92675
- Sun 4pm-10pm, Tue-Wed 4pm-10:30pm, Thu 4pm-11:30pm, Fri-Sat 4pm-1am
- $$
- Catering, Takeout
- Dinner
- Full bar
- Parking Lot Available
- Reservations Accepted
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When I see that a restaurant serves Mexican fusion cuisine, I get excited. When I see Mexican fusion, I think that the chef understands different worlds of flavor and is confident enough to bring them together tastily and tastefully...
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Michael Schepers (the namesake behind Mick's) knows his way around burgers like Pujols knows how ...American
Three Seventy Common is cozy and rustic restaurant in Laguna Beach with incredibly in-depth and b...American
The site was formerly Blue Laguna, which, like Mare was a clubby lounge set anachronistically ins...New American
The Corner is an American restaurant in Huntington Beach. The item that everybody will ask about ...American
Juliette Kitchen and Bar is in every way different from its location's predecessor Pascal Olhats'...New American
Xa offers seven flavor paths for your chicken, pork or fish, everything from a simple herbes de P...American


text:
Utah on Verge of a Tippling Point
Panel Moves to Ease Limits on Alcohol; The Mormon Sway
Ordering a cocktail in Utah could soon get much easier.
For four decades, Utah law has limited how alcohol is served in public. People can order a drink at a restaurant, but only if they order a meal with it. To get a drink without a meal, they must visit a "private club" -- an establishment that resembles a bar but charges a membership fee of at least $12 a year or $4 for three weeks. Beer with alcohol content of 4% or less is an exception.
Now the Utah Alcoholic Beverage Control Commission, which regulates liquor sales, is moving to loosen the rules. It voted this past Wednesday to lay the groundwork for a law to end the membership-fee requirement. The change would effectively allow private clubs to become regular bars. After public hearings, the commission hopes to propose a law to the state Legislature, which convenes in January. If the law is passed, it could be in place as early as a year from now.
Dave Morris, owner of the Salt Lake City bar Piper Down, said newcomers and tourists are often puzzled when they visit a bar and are asked at the door to pay a membership fee and fill out a form with their name and address. The typical reaction, according to Mr. Morris: "I just want one drink, man. I'm not looking for a lifetime commitment to coming to this bar."
The Utah liquor commission's chairman, a nondrinker named Sam Granato, said the commission is responding to a demographic shift. People from more-liberal urban areas in California and elsewhere have been moving to Utah, Wyoming, Colorado and Idaho, seeking a lower cost of living.
Utah is a stronghold for Mormons -- members of the Church of Jesus Christ of Latter-day Saints. Mormon doctrine prohibits drinking alcohol and coffee. Over the past 20 years, though, people have flocked to the state from throughout the West to vacation, retire or pursue jobs.
It can be extrapolated from membership data provided by the church to the state that Mormons made up about 60% of Utah's population in 2007, down from about 65% in 2000, according to the Utah governor's office. (The Mormon Church disputes that calculation, saying its members make up 70% of the state population, but acknowledges that the percentage of Mormons versus non-Mormons is declining.)
Revenue from liquor sold in Utah has doubled in the past decade, to $230 million in 2007 from about $113 million in 1997. The state Department of Alcoholic Beverage Control expects growth to continue, with liquor sales reaching $260 million this year and $675 million in 2020.
"A lot of the people that are moving into the state are social drinkers," said John Freeman, the department's deputy director. Because the state runs Utah's liquor stores and supplies liquor to bars, any plan to boost liquor sales also would help state coffers, Mr. Freeman said.
The liquor commission's move reflects the view of Utah Gov. Jon Huntsman Jr., who appointed four of the commission's five members. Tourism groups also favor loosening the rules. Many other states with such laws -- often vestiges of Prohibition -- have rescinded them.
"Reforming our outdated alcohol policies is something we take seriously, since it has a direct impact on our economic viability in today's highly mobile world," Gov. Huntsman said in an email. "Ultimately it will be important for our state to be more in line with prevailing policies found across the country."
Mr. Granato, the liquor-commission chairman, said, "Being appointed by the governor, we're taking his lead."
Mr. Granato said the Mormon Church hasn't commented on the commission's proposal, but could weigh in if a law is proposed. A church spokeswoman declined to comment.
Mormons make up about 80% of the Legislature. "If the church came out clearly against it, that would make it very difficult to move anything through the Legislature," said Quin Monson, a political-science professor at Brigham Young University.
The largest clubs in Utah reap hundreds of thousands of dollars a year in revenue from membership fees. Some said losing those fees could hurt their overall sales, though others expect increased traffic to make up for it.
Write to Vauhini Vara at email@example.com


text:
King's Venues Hampstead Residence
University campus offering single and twin rooms in modern and turn-of-the-century buildings. Function rooms available.
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Timothy Pratt, The Hechinger Report
Timothy's Most Recent Stories
April 26, 2016
A lack of basic financial knowledge and advice is aggravating student debt and defaults. Student financial ambassadors are looking to help. Continue reading →
August 27, 2014
Advocates of online higher education hope this first-ever attempt by an elite institution to offer an entire computer-science graduate program in a MOOC-style format will prove the value of so-called massively open online courses. Continue reading →


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TIP has been successfully added into Your Stock Email Alerts list.
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Please enter Portfolio Name for new portfolio.
GuruFocus Financial Strength Rank measures how strong a companys financial situation is. It is based on these factors
1. The debt burden that the company has as measured by its Interest coverage (current year).
2. Debt to revenue ratio. The lower, the better
3. Altman Z-score.
A company ranks high with financial strength is likely to withstand any business slowdowns and recessions.
1. Operating Margin
2. Trend of the Operating Margin (5-year average). The company with an uptrend profit margin has a higher rank.
3. Consistency of the profitability
4. Piotroski F-Score
5. Predictability Rank
|Ken Fisher 7,278 sh (+17.29%)
|John Buckingham 3,831 sh (-28.26%)
|Manning & Napier Advisors, Inc 1,935 sh (New)
Ken Fisher 7,369 sh (+1.25%)
|John Buckingham Sold Out
|Manning & Napier Advisors, Inc 1,936 sh (+0.05%)
|Ken Fisher 7,240 sh (-1.75%)
|Manning & Napier Advisors, Inc 3,685 sh (+90.34%)
Ken Fisher 7,306 sh (+0.91%)
|Dividend Yield
100% of the Companies
in the Global industry.
( Industry Median: vs. TIP: 3.08 )
Ranked among companies with meaningful Dividend Yield only.
TIP' s Dividend Yield Range Over the Past 10 Years
Min: 0 Med: 0 Max: 3.12
Current: 3.08
|Yield on cost (5-Year)
100% of the Companies
in the Global industry.
( Industry Median: vs. TIP: 3.08 )
Ranked among companies with meaningful Yield on cost (5-Year) only.
TIP' s Yield on cost (5-Year) Range Over the Past 10 Years
Min: 0 Med: 0 Max: 3.12
Current: 3.08
|Short Percentage of Float
|52-Week Range $
|109.15 - 117.55
|Shares Outstanding (Mil)
|Software Companies Show High Value Potential Sep 29 2016
|Third Avenue Value Fund Reduces Masco Stake Sep 29 2016
|Carl Icahn Clears More Oil Out of Portfolio With Transocean Sell Sep 29 2016
|Deutsche Bank's Losses Affecting the Market on Thursday Sep 29 2016
|What I Learned From Larry Ellison Sep 29 2016
|Natus Medical CEO Acquires Shares in Company Sep 29 2016
|Sears Holdings' Spin-Off Seritage Can Develop Land Sep 29 2016
|12 Questions With Validea Capital Management John Reese Sep 29 2016
|Domino's Not a Great Buy at This Point Sep 29 2016
|Walmart's Flipkart Investment Sep 29 2016
|Are Policymakers Happy with the Job Market? Sep 27 2016
|Why Safe Haven Assets Could Gather Strength Sep 20 2016
|Fight Inflation With These ETFs Sep 20 2016
|The Fixed-Income Challenge: The Monetary Policy Pit Sep 15 2016
|Why Is The Fed So Hesitant To Raise Interest Rates? Sep 12 2016
|Best ETFs: Inflation-proof Bonds Aug 23 2016
|5-Year TIPS Were Auctioned at a Negative Yield Again Aug 22 2016
|PCE Inflation Expected to Remain Low for Now, but on Path to 2% Aug 22 2016
|The Bond ETF Trade Investors Have Nailed Aug 19 2016
|Why Bonds Are No Longer Safe to Hold Aug 15 2016
|7 Best ETF Picks For Rest Of 2016: Gearing For Inflation As Economy Strengthens Aug 12 2016
|Is PCE Inflation Good Enough for a Rate Hike in 2016? Jul 29 2016
|A Look at the Outlook for TIPS Jul 27 2016
|Key Charts For Fed Day Jul 27 2016
|The Relationship between TIPS and the Break-Even Rate Jul 26 2016
|How Can TIPS Add Value to Your Portfolio? Jul 26 2016
|Volatile year to continue Jul 25 2016
|The 3 Biggest iShare Bond ETFs (AGG, LQD) Jul 23 2016
|The Outlook for Fixed Income: Stagnant Prices, Tighter Money Jul 22 2016
|What's Next For Central Planners And Their Kale Smoothie Economy? Jul 17 2016


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Best route map between Jackson, MS and Pigeon Forge, TN. This route take about 528 Miles.
The distance and estimated time is placed on the right depending on the status of the road.
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BOISE, Idaho -- Albertson's here said it plans to enter at least one new marketing area during the next five years. of 388 new stores -- a rate of growth that Albertson's thinks will require it to expand into a new operating area, Michael Read, director of public relations and government affairs, told SN. However, he said, Albertson's has not decided yet on where that area will be or when it would enter it. Earlier this year Albertson's entered the Houston market, where it operates 17 ...
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Skip to comments.Amy's Place ... Poetry and Potpourri ... April, 2012
Posted on 03/31/2012 10:08:43 PM PDT by JustAmy
A Beautiful, Pain-Free Day Prayed for you, my Sweet FRiend.
(((((Looking with you to Jesus for Every Kindness and Mercy of Heaven)))))
(((((We Missed you!)))))
Bummer that you are having computer problems! They can be SO frustrating! Hope you're back to normal...computer-wise...soon! :)
Thank you Luv, and yes, its very annoying at times!! And I
loved your pretty orange graphic and scripture today!
Thanks, Jaycee! Loved yours too...and appreciate it even more
because of the effort it took you to get it posted! :)
It was worth your time. *smile*
Hope you're feeling better!
Thank you, Luv!
Thanks! Lovin' your GratiTuesday theme! :)
Cute graphic!!
Hi Conor, Thank you for that beautiful song and the musical graphics were very pretty!
Absolutely! And we all have always adored the picture!!
Thank you for your Tuesday Cuties, Conor. I love that graphic. Wonderful song as well!
You're welcome. I'm happy to hear of your gratitude! ;)
The beauty of the black lacy design against the pastel purple and orange background grabbed my attention. The intricacy of the fragile pattern led me to assume that it had been created by a skilled artist. As I looked more closely at the photo, however, I saw the artist admiring his work from a corner of the photo. The artist was a worm, and its work of art was a partially eaten leaf.
What made the image beautiful was not the destruction of the leaf but the light glowing through the holes. As I gazed at the photo, I began thinking about lives that have been eaten by the worms of sin. The effects are ravaging. Sin eats away at us as we suffer the consequences of our own bad choices or those of others. We are all its victims.
But the photo also reminded me of the hope we have in God. Through the prophet Joel, God said to Israel, I will restore to you the years that the swarming locust has eaten (Joel 2:25). And from Isaiah we learn that the Lord appointed him to console those who mourn in Zion, to give them beauty for ashes (Isa. 61:3).
Satan does everything he can to make us ugly, but the Light of the World can make us beautifuldespite Satans best efforts.
Read: Read: Joel 2:18-27
We are amid wonders about which we have a small inkling of how they work and perhaps ideas about their source but really ... we know how to manipulate them but little else.
Imagine ... if we can a universe without light!!!
God is light, We are to be filled with light and to let our light shine to everyone that sees us or comes into our space.
Thank Thee Father for light, It is WONDERFUL. A gift without measure. Glory be to God in Jesus name, amen.
"Everything is Beautiful"
Thank you for today's lesson, Rus.
Have a WFWednesday.
Good morning, Jaycee.
I will be thinking of and praying for you today.
Wishing you a beautiful pain-free WF day.
Wonderful, Conor. Thank you. Hope your Tuesday was terrific.
Hope you Tuesday was a delight.
Sorry to hear of your trouble posting this, Jaycee. I love it and am so happy you didn't give up.
I didn't get back yesterday to let you know how much I enjoyed ths post, Kitty. Thank you for sharing it with us.
Also, thanks for the hugs and the prayers.
"Wednesday Hugs" {{{{ Kitty }}}}
Thanking God For your good news report, Conor.
Hi, Amy! Glad you liked it...it's one of our more colorful day lilies!
So cute, Meg. Thank you.
Have a Warm Fuzzy Wednesday.
"Now four years post-treatment and everything looks good!"
Wonderful news, Conor. Thank you Father!
Have a beautiful day.
Dittos and Amen.
I have a dentist appt this morning. A darn cavity!
Wishing everyone a Wonderful, Warm, Fuzzy Wednesday.
Thank you..and thank you for the precious opening.
Hate those..May it be as painfree as possible, Amy.
(((((Thank you, Dear Teenie!)))))
(((((Beautiful Post, Sweet FRiend!)))))
Just don't tinkle on them LOL. Felt well enough to go whack the dead black berry canes, not a ton of them, but enough to make me glad there was no more, they are blooming, berries mid to late June/July.
Got the second batch of strawberries and have enough for a freezer bag, plus some for ice cream tonight. And a few for the 2 girls next door, darling girls, so well behaved for 5 and 10.
NO I did not pick them, my son did, he is doing the yard work right now with both of us down. Dean got his dressing off, and it turns out he is allergic to the clear tape stuff the hold it on with, the stitches will self destruct. Stuff is fine for just a short IV stay, but not for surgical dressing to be worn for a week.
My BELLY/skin fold, the pain and the infections will be GONE next Wed morning...she is even getting the big stretch mark that has a pocket, which is the source of the infections. Won't look like a 20 year old, not possible on a nearly 64, she will tighten stomach muscles too.... but will have all the source of the misery GONE. And I can say I only weighed 121 on her scale.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
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text:
Despite the two incidents and the usual reports of broken windows, this Christmas holiday was relatively quiet, Mr. Starks said.
Maybe people are starting to see its their community theyre tearing up, he said.
Someone kicked in three doors at East Augusta Middle School over Christmas break and vandalized portable classrooms at Hains Elementary School, according to Benton Starks, the Richmond County school systems senior director of facilities services.
Despite the two incidents and the usual reports of broken windows, this Christmas holiday was relatively quiet, Mr. Starks said.
Maybe people are starting to see its their community theyre tearing up, he said.
I can't believe that RCSO didn't see these things before school returned. If the deputies were patrolling these areas like they should be then these vandals may have been caught in the act.
Just another idiot with no education not wanting others to have an education........
Hey AugustaVoter, maybe if the BOE Police did their jobs, they would have found it.
Waymore they were off just like the rest of the BOE staff.
The Deputies probably thought it was the normal state that these properties are in thanks to BOE.
AugustaVoter, why is that? They are the Police for the BOE. Why does the responsibility of protecting their property fall to the S.O.? Why doesn't the Chief of the Public Safety Division schedule properly to make sure that at least one or two BOE officers are working at all times?
typical richmond county behavior. trashy kids trashing schools
The Campus Police along with the RCSO are responsible for patrolling the school grounds. However, the BOE Campus Police Director doesn't have a clue as to how to manage a department. She is a left over "terrible hire" with zero experience from the previous administration repaying favors. As for the Sheriff's Office, they are currently over 40 deputies short of their needs and incase you didn't notice a large portion of their time was unnecessarily spent monitoring adults acting like children at Cherry Tree Crossing over the holidays.
AugustaVoter...you are a real idiot. It is not the responsibility of the RCSO to patrol the schools. That is why you pay taxes for BOE police. Also, moron, if you truly understood how things worked then you would never have made that statement. RCSO road patrol can not actively patrol as proactively as we would LIKE TO, due to the constant answering of stupid calls and the shortage of deputies. Maybe if you idiots with cell phones stuck to your heads would quit calling 911 everytime you see a car speeding(as if you yourself dont do it) or anytime you see a "suspicious" black male walking on a street we would have the time to patrol more.


text:
Most Cited Journal of Hepatology Articles
The most cited articles published since 2011, extracted from Scopus.
EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinomaJosep M. Llovet | Michel Ducreux | Riccardo Lencioni | Adrian M. Di Bisceglie | Peter R. Galle | Jean Francois Dufour | Tim F. Greten | Eric Raymond | Tania Roskams | Thierry De Baere | Vincenzo Mazzaferro | Mauro Bernardi | Jordi Bruix | Massimo Colombo | Andrew Zhu
Volume 56, Issue 4, April 2012, Pages 908-943
EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
Volume 57, Issue 1, July 2012, Pages 167-185
EASL clinical practice guidelines: Management of hepatitis C virus infection
Volume 55, Issue 2, August 2011, Pages 245-264
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
Volume 60, Issue 2, February 2014, Pages 392-420
Endoplasmic reticulum stress in liver diseaseHarmeet Malhi | Randal J. Kaufman
Volume 54, Issue 4, April 2011, Pages 795-809
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin protein (BiP)/glucose-regulated protein 78 (GRP78). The accumulation of unfolded proteins sequesters BiP so it dissociates from three ER-transmembrane transducers leading to their activation. These transducers are inositol requiring (IRE) 1α, PKR-like ER kinase (PERK), and activating transcription factor (ATF) 6α. PERK phosphorylates eukaryotic initiation factor 2 alpha (eIF2α) resulting in global mRNA translation attenuation, and concurrently selectively increases the translation of several mRNAs, including the transcription factor ATF4, and its downstream target CHOP. IRE1α has kinase and endoribonuclease (RNase) activities. IRE1α autophosphorylation activates the RNase activity to splice XBP1 mRNA, to produce the active transcription factor sXBP1. IRE1α activation also recruits and activates the stress kinase JNK. ATF6α transits to the Golgi compartment where it is cleaved by intramembrane proteolysis to generate a soluble active transcription factor. These UPR pathways act in concert to increase ER content, expand the ER protein folding capacity, degrade misfolded proteins, and reduce the load of new proteins entering the ER. All of these are geared toward adaptation to resolve the protein folding defect. Faced with persistent ER stress, adaptation starts to fail and apoptosis occurs, possibly mediated through calcium perturbations, reactive oxygen species, and the proapoptotic transcription factor CHOP. The UPR is activated in several liver diseases; including obesity associated fatty liver disease, viral hepatitis, and alcohol-induced liver injury, all of which are associated with steatosis, raising the possibility that ER stress-dependent alteration in lipid homeostasis is the mechanism that underlies the steatosis. Hepatocyte apoptosis is a pathogenic event in several liver diseases, and may be linked to unresolved ER stress. If this is true, restoration of ER homeostasis prior to ER stress-induced cell death may provide a therapeutic rationale in these diseases. Herein we discuss each branch of the UPR and how they may impact hepatocyte function in different pathologic states. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890Christophe Hézode | Hélène Fontaine | Céline Dorival | Dominique Larrey | Fabien Zoulim | Valérie Canva | Victor De Ledinghen | Thierry Poynard | Didier Samuel | Marc Bourlière | Jean Pierre Zarski | Jean Jacques Raabe | Laurent Alric | Patrick Marcellin | Ghassan Riachi | Pierre Henri Bernard | Véronique Loustaud-Ratti | Sophie Métivier | Albert Tran | Lawrence Serfaty | Armand Abergel | Xavier Causse | Vincent Di Martino | Dominique Guyader | Damien Lucidarme | Véronique Grando-Lemaire | Patrick Hillon | Cyrille Feray | Thong Dao | Patrice Cacoub | Isabelle Rosa | Pierre Attali | Ventzislava Petrov-Sanchez | Yoann Barthe | Jean Michel Pawlotsky | Stanislas Pol | Fabrice Carrat | Jean Pierre Bronowicki
Volume 59, Issue 3, September 2013, Pages 434-441
Background & Aims In phase III trials, the safety profile of triple therapy (pegylated interferon/ribavirin with boceprevir or telaprevir) seems to be similar in HCV treatment-experienced cirrhotic and non-cirrhotic patients, but few cirrhotics were included. We report the week 16 safety and efficacy analysis in a cohort of compensated cirrhotics treated in the French Early Access Programme. Methods 674 genotype 1 patients, prospectively included, received 48 weeks of triple therapy. The analysis is restricted to 497 patients reaching week 16. Results A high incidence of serious adverse events (40.0%), and of death and severe complications (severe infection or hepatic decompensation) (6.4%), and a difficult management of anaemia (erythropoietin and transfusion use in 50.7% and 12.1%) were observed. Independent predictors of anaemia <8 g/dl or blood transfusion were: female gender (OR 2.19, 95% CI 1.11-4.33, p = 0.024), no lead-in phase (OR 2.25, 95% CI 1.15-4.39, p = 0.018), age ≥65 years (OR 3.04, 95% CI 1.54-6.02, p = 0.0014), haemoglobin level (≤12 g/dl for females, ≤13 g/dl for males) (OR 5.30, 95% CI 2.49-11.5, p = 0.0001). Death or severe complications were related to platelets count ≤100,000/mm3 (OR 3.11, 95% CI 1.30-7.41, p = 0.0105) and albumin <35 g/dl (OR 6.33, 95% CI 2.66-15.07, p = 0.0001), with a risk of 44.1% in patients with both. However, the on-treatment virological response was high. Conclusions The safety profile was poor and patients with platelet count ≤100,000/mm3 and serum albumin <35 g/L should not be treated with the triple therapy. © 2013 European Association for the Study of the Liver.
Management of HCCCarlos Rodríguez De Lope | Silvia Tremosini | Alejandro Forner | María Reig | Jordi Bruix
Volume 56, Issue SUPPL. 1, February 2012, Page
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal neoplasia, the management of which has significantly improved during the last few years. A better knowledge of the natural history of the tumor and the development of staging systems that stratify patients according to the characteristics of the tumor, the liver disease, and the performance status, such as the BCLC (Barcelona Clinic Liver Cancer) system, have led to a better prediction of prognosis and to a most appropriate treatment approach. Today curative therapies (resection, transplantation, ablation) can improve survival in patients diagnosed at an early HCC stage and offer a potential long-term cure. Patients with intermediate stage HCC benefit from chemoembolization and those diagnosed at advanced stage benefit from sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects. In this article we review the current management in HCC and the new advances in this field. © 2012 European Association for the Study of the Liver.
The burden of liver disease in Europe: A review of available epidemiological dataMartin Blachier | Henri Leleu | Markus Peck-Radosavljevic | Dominique Charles Valla | Françoise Roudot-Thoraval
Volume 58, Issue 3, March 2013, Pages 593-608
To survey the burden of liver disease in Europe and its causes 260 epidemiological studies published in the last five years were reviewed. The incidence and prevalence of cirrhosis and primary liver cancer are key to understand the burden of liver disease. They represent the end-stage of liver pathology and thus are indicative of the associated mortality. About 0.1% of Hungarian males will die of cirrhosis every year compared with 0.001% of Greek females. WHO estimate that liver cancer is responsible for around 47,000 deaths per year in the EU. Harmful alcohol consumption, viral hepatitis B and C and metabolic syndromes related to overweight and obesity are the leading causes of cirrhosis and primary liver cancer in Europe. Chronic hepatitis B affects 0.5-0.7% of the European population. In the last decade the prevalence of chronic hepatitis C was 0.13-3.26%. It is of great concern that about 90% of people in Europe infected by viral hepatitis are unaware of their status. Available data suggest the prevalence rate of NAFLD is 2-44% in the general European population (including obese children) and 42.6-69.5% in people with type 2 diabetes. Each of these four major causes of liver disease is amenable to prevention and treatment, reducing the burden of liver disease in Europe and saving lives. Further surveys are urgently needed to implement cost-effective prevention programmes and novel treatments to tackle this problem.
Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracyE. A. Tsochatzis | K. S. Gurusamy | S. Ntaoula | E. Cholongitas | B. R. Davidson | A. K. Burroughs
Volume 54, Issue 4, April 2011, Pages 650-659
Background & Aims: Transient elastography is a non-invasive method, for the assessment of hepatic fibrosis, developed as an alternative to liver biopsy. We studied the performance of elastography for diagnosis of fibrosis using meta-analysis. Methods: MEDLINE, EMBASE, SCI, Cochrane Library, conference abstracts books, and article references were searched. We included studies using biopsy as a reference standard, with the data necessary to calculate the true and false positive, true and false negative diagnostic results of elastography for a fibrosis stage, and with a 3-month maximum interval between tests. The quality of the studies was rated with the QUADAS tool. Results: We identified 40 eligible studies. Summary sensitivity and specificity was 0.79 (95% CI 0.74-0.82) and 0.78 (95% CI 0.72-0.83) for F2 stage and 0.83 (95% CI 0.79-0.86) and 0.89 (95% CI 0.87-0.91) for cirrhosis. After an elastography result at/over the threshold value for F2 or cirrhosis ("positive" result), the corresponding post-test probability for their presence (if pre-test probability was 50%) was 78%, and 88% respectively, while, if values were below these thresholds ("negative" result), the post-test probability was 21% and 16%, respectively. No optimal stiffness cut-offs for individual fibrosis stages were validated in independent cohorts and cut-offs had a wide range and overlap within and between stages. Conclusions: Elastography theoretically has good sensitivity and specificity for cirrhosis (and less for lesser degrees of fibrosis); however, it should be cautiously applied to everyday clinical practice because there is no validation of the stiffness cut-offs for the various stages. Such validation is required before elastography is considered sufficiently accurate for non-invasive staging of fibrosis. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menaceGyörgy Baffy | Elizabeth M. Brunt | Stephen H. Caldwell
Volume 56, Issue 6, June 2012, Pages 1384-1391
Hepatocellular carcinoma (HCC) is a common cancer worldwide that primarily develops in cirrhosis resulting from chronic infection by hepatitis B virus and hepatitis C virus, alcoholic injury, and to a lesser extent from genetically determined disorders such as hemochromatosis. HCC has recently been linked to non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity and related metabolic disorders such as diabetes. This association is alarming due to the globally high prevalence of these conditions and may contribute to the rising incidence of HCC witnessed in many industrialized countries. There is also evidence that NAFLD acts synergistically with other risk factors of HCC such as chronic hepatitis C and alcoholic liver injury. Moreover, HCC may complicate non-cirrhotic NAFLD with mild or absent fibrosis, greatly expanding the population potentially at higher risk. Major systemic and liver-specific molecular mechanisms involved include insulin resistance and hyperinsulinemia, increased TNF signaling pathways, and alterations in cellular lipid metabolism. These provide new targets for prevention, early recognition, and effective treatment of HCC associated with NAFLD. Indeed, both metformin and PPAR gamma agonists have been associated with lower risk and improved prognosis of HCC. This review summarizes current evidence as it pertains to the epidemiology, pathogenesis, and prevention of NAFLD-associated HCC. © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Global epidemiology and genotype distribution of the hepatitis C virus infectionErin Gower | Chris Estes | Sarah Blach | Kathryn Razavi-Shearer | Homie Razavi
Volume 61, Issue 1, January 2014, Pages S45-S57
© 2014 European Association for the Study of the Liver.The treatment of chronic hepatitis C virus (HCV) infection has the potential to change significantly over the next few years as therapeutic regimens are rapidly evolving. However, the burden of chronic infection has not been quantified at the global level using the most recent data. Updated estimates of HCV prevalence, viremia and genotypes are critical for developing strategies to manage or eliminate HCV infection. To achieve this, a comprehensive literature search was conducted for anti-HCV prevalence, viraemic prevalence and genotypes for all countries. Studies were included based on how well they could be extrapolated to the general population, sample size and the age of the study. Available country estimates were used to develop regional and global estimates. Eighty-seven countries reported anti-HCV prevalence, while HCV viraemic rates were available for fifty-four countries. Total global viraemic HCV infections were estimated at 80 (64-103) million infections. Genotype distribution was available for ninety-eight countries. Globally, genotype 1 (G1) was the most common (46%), followed by G3 (22%), G2 (13%), and G4 (13%). In conclusion, the total number of HCV infections reported here are lower than previous estimates. The exclusion of data from earlier studies conducted at the peak of the HCV epidemic, along with adjustments for reduced prevalence among children, are likely contributors. The results highlight the need for more robust surveillance studies to quantify the HCV disease burden more accurately.
Antiviral strategies in hepatitis C virus infectionChristoph Sarrazin | Christophe Hézode | Stefan Zeuzem | Jean Michel Pawlotsky
Volume 56, Issue SUPPL. 1, February 2012, Page
Resolution of the three-dimensional structures of several hepatitis C virus (HCV) proteins, together with the development of replicative cell culture systems, has led to the identification of a number of potential targets for direct-acting antiviral (DAA) agents. Numerous families of drugs that potently inhibit the HCV lifecycle in vitro have been identified, and some of these molecules have reached early to late clinical development. Two NS3/4A protease inhibitors, telaprevir and boceprevir, were approved in Europe and the United States in 2011 in combination with pegylated interferon (IFN)-α and ribavirin for the treatment of chronic hepatitis C related to HCV genotype 1, in both treatment-naïve and treatment-experienced patients. Sustained virological response rates in the range of 6675 and 5966 (2988 if the response to the first course of therapy is taken into account) have been achieved in these two patient populations, respectively, with treatment durations of 24 to 48 weeks. A number of other DAAs are at the clinical developmental stage in combination with pegylated IFN-α and ribavirin or with other DAAs in IFN-free regimens, with or without ribavirin. They include second-wave, first-generation, and second-generation NS3/4A protease inhibitors, nucleoside/nucleotide analogue inhibitors and non-nucleoside inhibitorsof HCVRNA-dependent RNA polymerase, inhibitors of nonstructural protein 5A (NS5A) and host-targeted compounds, such as cyclophilin inhibitors and silibinin. The proof of concept that IFN-free regimens may lead to HCV eradication has recently been brought. However, new drugs may be associated with troublesome side effects and drugdrug interactions, and the ideal IFN-free DAA combination remains to be found. © 2012 European Association for the Study of the Liver.
EASL Recommendations on Treatment of Hepatitis C 2015
Volume 63, Issue 1, January 2015, Pages 199-236
Hepatitis C virus resistance to protease inhibitorsPhilippe Halfon | Stephen Locarnini
Volume 55, Issue 1, July 2011, Pages 192-206
Recent advances in molecular biology have led to the development of novel small molecules that target specific viral proteins of the hepatitis C virus (HCV) life cycle. These drugs, collectively termed directly acting antivirals (DAA) against HCV, include a range of non-structural (NS) 3/NS4A protease, NS5B polymerase, and NS5A inhibitors at various stages of clinical development. The rapid replication rate of HCV, along with the low fidelity of its polymerase, gives rise to generations of mutations throughout the viral genome resulting in remarkable sequence variation in the HCV population, known as a quasispecies. The efficacy of DAAs is limited by the presence of those mutations that give rise to amino-acid substitutions within the targeted protein, and that affect the viral sensitivity to these compounds. Thus, due to the high genetic variability of HCV, variants with reduced susceptibility to DAA can occur naturally even before treatment begins, but usually at low levels. Not surprisingly then, these changes are selected in patients either breaking through or not responding to potent DAA treatment. In vitro or in vivo, six major position mutations in the NS3 HCV protease (36, 54, 155, 156, 168, and 170) have now been reported associated with different levels of resistance. The amino acid composition at several of the drug resistance sites can vary between the HCV genotypes/subtypes, resulting in different consensus amino acids leading to a reduction in replicative fitness as well as reduced DAA sensitivity. Different amino acid diversity profiles for HCV genotypes/subtypes suggest differences in the position/type of immune escape and drug resistance mutations. Also, different pathways of resistance profiles based on the chemical scaffold (linear or macrocyclic) of the protease inhibitors have been described. This review first describes how resistance to a protease inhibitor can develop and then provides an overview of the mechanism of how particular mutations confer varying levels of resistance to protease inhibitor, which have been identified and characterized using both genotypic and phenotypic tools. Future potential therapeutic strategies to assist patients who do develop resistance to protease inhibitors are also outlined. The challenge developing new HCV protease inhibitors should take into consideration not only the antiviral potency of the drugs, the occurrence and importance of side effects, the frequency of oral administration, but also the resistance profiles of these agents. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Acute-on chronic liver failureRajiv Jalan | Pere Gines | Jody C. Olson | Rajeshwar P. Mookerjee | Richard Moreau | Guadalupe Garcia-Tsao | Vicente Arroyo | Patrick S. Kamath
Volume 57, Issue 6, December 2012, Pages 1336-1348
Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention. © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in JapanHiromitsu Kumada | Joji Toyota | Takeshi Okanoue | Kazuaki Chayama | Hirohito Tsubouchi | Norio Hayashi
Volume 56, Issue 1, January 2012, Pages 78-84
Background & Aims: To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C. Methods: In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprevir for 12 weeks along with PEG-IFN and RBV for 24 weeks (Group A), while 63 to PEG-IFN and RBV for 48 weeks (Group B). Results: HCV RNA disappeared more swiftly in patients in Group A than B, and the frequency of patients without detectable HCV RNA at week 4 (rapid virological response (RVR)) was higher in Group A than B (84.0% vs. 4.8%, p <0.0001). Grade 3 and 4 skin disorders, including Stevens-Johnson syndrome and drug rashes with eosinophilia and systemic symptoms, as well as Grade 3 anemia (<8.0 g/dl), occurred more frequently in Group A than B (skin disorders, 11.9% vs. 4.8%; anemia, 11.1% vs. 0.0%). The total RBV dose was smaller in Group A than B (47.0% vs. 77.7% of the target, p <0.0001). Despite these drawbacks, sustained virological response (SVR) was achieved more frequently in Group A than B (73.0% vs. 49.2%, p = 0.0020). Conclusions: Although the triple therapy with telaprevir-based regimen for 24 weeks resulted in more adverse events and less total RBV dose than PEG-IFN and RBV for 48 weeks, it was able to achieve higher SVR within shorter duration by carefully monitoring adverse events and modifying the RBV dose as required. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
EASL clinical practical guidelines: Management of alcoholic liver disease
Volume 57, Issue 2, August 2012, Pages 399-420
Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trialJordi Bruix | Jean Luc Raoul | Morris Sherman | Vincenzo Mazzaferro | Luigi Bolondi | Antonio Craxi | Peter R. Galle | Armando Santoro | Michel Beaugrand | Angelo Sangiovanni | Camillo Porta | Guido Gerken | Jorge A. Marrero | Andrea Nadel | Michael Shan | Marius Moscovici | Dimitris Voliotis | Josep M. Llovet
Volume 57, Issue 4, October 2012, Pages 821-829
Background & Aims: The Sorafenib Hepatocellular Carcinoma (HCC) Assessment Randomized Protocol (SHARP) trial demonstrated that sorafenib improves overall survival and is safe for patients with advanced HCC. In this trial, 602 patients with well-preserved liver function (>95% Child-Pugh A) were randomized to receive either sorafenib 400 mg or matching placebo orally b.i.d. on a continuous basis. Because HCC is a heterogeneous disease, baseline patient characteristics may affect individual responses to treatment. In a comprehensive series of exploratory subgroup analyses, data from the SHARP trial were analyzed to discern if baseline patient characteristics influenced the efficacy and safety of sorafenib. Methods: Five subgroup domains were assessed: disease etiology, tumor burden, performance status, tumor stage, and prior therapy. Overall survival (OS), time to progression (TTP), disease control rate (DCR), and safety were assessed for subgroups within each domain. Results: Subgroup analyses showed that sorafenib consistently improved median OS compared with placebo, as reflected by hazard ratios (HRs) of 0.50-0.85, similar to the complete cohort (HR = 0.69). Sorafenib also consistently improved median TTP (HR, 0.40-0.64), except in HBV-positive patients (HR, 1.03), and DCR. Results are limited by small patient numbers in some subsets. The most common grade 3/4 adverse events included diarrhea, hand-foot skin reaction, and fatigue; the incidence of which did not differ appreciably among subgroups. Conclusions: These exploratory subgroup analyses showed that sorafenib consistently improved median OS and DCR compared with placebo in patients with advanced HCC, irrespective of disease etiology, baseline tumor burden, performance status, tumor stage, and prior therapy. © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patientsChristoph Sarrazin | Simone Susser | Alexandra Doehring | Christian Markus Lange | Tobias Müller | Christina Schlecker | Eva Herrmann | Jörn Lötsch | Thomas Berg
Volume 54, Issue 3, March 2011, Pages 415-421
Background & Aims: Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. Methods: In patients with chronic hepatitis C genotype 2/3 (n = 267), IL28B host genotypes (rs8099917, rs12980275 and rs12979860) were analyzed for associations with sustained virologic response (SVR) to antiviral therapy with (pegylated) interferon-alfa and ribavirin and with respect to epidemiological, biochemical, and virological parameters. For comparison, hepatitis C genotype 1 patients (n = 378) and healthy controls (n = 200) were included. Results: The rs12979860 CC genotype, lower age, and genotype 2 were significantly associated with SVR in HCV genotype 2/3-infected patients (p = 0.01, p = 0.03 and p = 0.03, respectively). No association was observed for rs8099917 and rs12980275. In addition, an SVR in patients with rapid virologic response (RVR) was associated with the rs12979860 CC genotype (p = 0.05), while for non-RVR no association was found. Furthermore, a significant association with a higher baseline viral load was observed for all three IL28B genotypes in genotype 1/2/3-infected patients. Finally, increasing frequencies of the rs12979860 CC genotypes were observed in genotype 1- (33.9%), genotype 3- (38.9%), and genotype 2-infected (51.9%) patients in comparison with healthy controls (49.0%) (p <0.01). Conclusions: In genotype 2/3-infected patients, rs12979860 was significantly associated with SVR. The frequency of the rs12979860 CC genotype is lower in HCV genotype 1 vs. genotype 2/3 patients. All major IL28B genotypes are associated with HCV-RNA concentration. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issueKirsten Muri Boberg | Roger W. Chapman | Gideon M. Hirschfield | Ansgar W. Lohse | Michael P. Manns | Erik Schrumpf
Volume 54, Issue 2, February 2011, Pages 374-385
Some patients present with overlapping features between disorders within the spectrum of autoimmune liver diseases (i.e. autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC)) and are commonly classified as having an "overlap syndrome". Standardized definitions of "overlap syndromes" are lacking. The aim of this report by the International Autoimmune Hepatitis Group (IAIHG) is to evaluate if there are important reasons to classify conditions with overlapping features between autoimmune liver diseases as separate diagnostic entities. Definition of diagnostic criteria for overlap conditions can only be arbitrary. The IAIHG scoring system for diagnosis of AIH has been widely used to diagnose "overlap syndromes", but was not intended for such use and has not proven to be an efficient tool for this purpose. Some patients with overlapping features between a cholestatic and hepatitic disorder appear to benefit from treatment with a combination of ursodeoxycholic acid and immunosuppressants, but this strategy is not evidence-based, and it seems unjustified to define new diagnostic groups in this regard. The IAIHG suggests that patients with autoimmune liver disease should be categorized according to the predominating feature(s) as AIH, PBC, and PSC/small duct PSC, respectively, and that those with overlapping features are not considered as being distinct diagnostic entities. The IAIHG scoring system should not be used to establish subgroups of patients. Patients with PBC and PSC with features of AIH should be considered for immunosuppressive treatment. Due to the low prevalence of such "overlap syndromes", prospective interventional therapeutic trials cannot be expected in the foreseeable future. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Hepatitis B surface antigen quantification: Why and how to use it in 2011 - A core group reportHenry Lik Yuen Chan | Alex Thompson | Michelle Martinot-Peignoux | Teerha Piratvisuth | Markus Cornberg | Maurizia Rossana Brunetto | Hans L. Tillmann | Jia Horng Kao | Ji Dong Jia | Heiner Wedemeyer | Stephen Locarnini | Harry L A Janssen | Patrick Marcellin
Volume 55, Issue 5, November 2011, Pages 1121-1131
Quantitative HBsAg had been suggested to be helpful in management of HBV, but assays were cumbersome. The recent availability of commercial quantitative assays has restarted the interest in quantitative serum hepatitis B surface antigen (HBsAg) as a biomarker for prognosis and treatment response in chronic hepatitis B. HBsAg level reflects the transcriptional activity of cccDNA rather than the absolute amount of cccDNA copies. Serum HBsAg level tends to be higher in hepatitis B e antigen (HBeAg)-positive than HBeAg-negative patients. Among patients with a low HBV DNA (<2000 IU/ml), HBsAg <1000 IU/ml in genotype D HBV infection and HBsAg <100 IU/ml in genotype B/C HBV infection is associated with inactive carrier state in HBeAg-negative patients. The HBsAg reduction by nucleos(t)ide analogues (NA) is not as pronounced as by interferon treatment. On peginterferon treatment, sustained responders tend to show greater HBsAg decline than the non-responders. The optimal on-treatment HBsAg cutoff to predict response needs further evaluation in HBeAg-positive patients, but an absence of HBsAg decline together with a <2 log reduction in HBV DNA at week 12 can serve as stopping rule in HBeAg-negative patients with genotype D HBV infection. A rapid serum HBsAg decline during NA therapy may identify patients who will clear HBsAg in the long-term. There are early reports among Asian patients that an HBsAg level of <100 IU/ml might predict lower risk of relapse after stopping NA treatment. In clinical practice, serum HBsAg level should be used together with, but not as a substitute for, HBV DNA. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver diseaseMark L. Palmeri | Michael H. Wang | Ned C. Rouze | Manal F. Abdelmalek | Cynthia D. Guy | Barry Moser | Anna Mae Diehl | Kathryn R. Nightingale
Volume 55, Issue 3, September 2011, Pages 666-672
Background & Aims: Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease in developed countries, may progress to nonalcoholic steatohepatitis (NASH) in a minority of people. Those with NASH are at increased risk for cirrhosis and hepatocellular carcinoma. The potential risk and economic burden of utilizing liver biopsy to stage NAFLD in an overwhelmingly large at-risk population are enormous; thus, the discovery of sensitive, inexpensive, and reliable noninvasive diagnostic modalities is essential for population-based screening. Methods: Acoustic Radiation Force Impulse (ARFI) shear wave imaging, a noninvasive method of assessing tissue stiffness, was used to evaluate liver fibrosis in 172 patients diagnosed with NAFLD. Liver shear stiffness measures in three different imaging locations were reconstructed and compared to the histologic features of NAFLD and AST-to-platelet ratio indices (APRI). Results: Reconstructed shear stiffnesses were not associated with ballooned hepatocytes (p = 0.11), inflammation (p = 0.69), nor imaging location (p = 0.11). Using a predictive shear stiffness threshold of 4.24 kPa, shear stiffness distinguished low (fibrosis stage 0-2) from high (fibrosis stage 3-4) fibrosis stages with a sensitivity of 90% and a specificity of 90% (AUC of 0.90). Shear stiffness had a mild correlation with APRI (R 2 = 0.22). BMI >40 kg/m 2 was not a limiting factor for ARFI imaging, and no correlation was noted between BMI and shear stiffness (R 2 = 0.05). Conclusions: ARFI imaging is a promising imaging modality for assessing the presence or absence of advanced fibrosis in patients with obesity-related liver disease. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysisHelen M. Parker | Nathan A. Johnson | Catriona A. Burdon | Jeffrey S. Cohn | Helen T. O'Connor | Jacob George
Volume 56, Issue 4, April 2012, Pages 944-951
Non-alcoholic fatty liver disease (NAFLD) is a frequent accompaniment of obesity and insulin resistance. With the prevalence approaching 85% in obese populations, new therapeutic approaches to manage NAFLD are warranted. A systematic search of the literature was conducted for studies pertaining to the effect of omega-3 polyunsaturated fatty acid (PUFA) supplementation on NAFLD in humans. Primary outcome measures were liver fat and liver function tests: alanine aminotransferase (ALT) and aspartate aminotransferase [1]. Data were pooled and meta-analyses conducted using a random effects model. Nine eligible studies, involving 355 individuals given either omega-3 PUFA or control treatment were included. Beneficial changes in liver fat favoured PUFA treatment (effect size = -0.97, 95% CI: -0.58 to -1.35, p <0.001). A benefit of PUFA vs. control was also observed for AST (effect size = -0.97, 95% CI: -0.13 to -1.82, p = 0.02). There was a trend towards favouring PUFA treatment on ALT but this was not significant (effect size = -0.56, 95% CI: -1.16 to 0.03, p = 0.06). Sub-analyses of only randomised control trials (RCTs) showed a significant benefit for PUFA vs. control on liver fat (effect size = -0.96, 95% CI: -0.43 to -1.48, p <0.001), but not for ALT (p = 0.74) or AST (p = 0.28). There was significant heterogeneity between studies. The pooled data suggest that omega-3 PUFA supplementation may decrease liver fat, however, the optimal dose is currently not known. Well designed RCTs which quantify the magnitude of effect of omega-3 PUFA supplementation on liver fat are needed. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)René Adam | Vincent Karam | Valérie Delvart | John O'Grady | Darius Mirza | Jurgen Klempnauer | Denis Castaing | Peter Neuhaus | Neville Jamieson | Mauro Salizzoni | Stephen Pollard | Jan Lerut | Andreas Paul | Juan Carlos Garcia-Valdecasas | Fernando San Juan Rodríguez | Andrew Burroughs
Volume 57, Issue 3, September 2012, Pages 675-688
A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infectionGuo Rong Han | Min Kai Cao | Wei Zhao | Hong Xiu Jiang | Cui Min Wang | Shu Fen Bai | Xin Yue | Gen Ju Wang | Xun Tang | Zhi Xun Fang
Volume 55, Issue 6, December 2011, Pages 1215-1221
Background & Aims: In the Asia-Pacific region, perinatal transmission of the hepatitis B virus (HBV) is the primary cause of chronic hepatitis B infection. Despite the use of HBIG and HBV vaccination, HBV perinatal transmission (PT) occurs in 10-30% of infants born to highly viremic mothers. We evaluated the efficacy and safety of LTD use during late pregnancy in reducing HBV transmission in highly viremic HBeAg+ mothers. Methods: Two hundred and twenty-nine HBeAg+ HBV DNA levels >1.0 × 10 7 copies/ml mothers received telbivudine 600 mg/day from week 20 to 32 of gestation (n = 135) or served as untreated controls (n = 94). All infants in both arms received 200 IU of HBIg within 12 h postpartum and recombinant HBV vaccine of 20 μg at 0, 1, and 6 months. HBsAg and HBV DNA results of infants at week 28 were used to determine perinatal transmission rate. All telbivudine treated subjects were registered in the Antiretroviral Pregnancy Registry. Results: Telbivudine treatment was associated with a marked reduction in serum HBV DNA and hepatitis B e antigen (HBeAg) levels and normalization of elevated ALT levels before delivery. A striking decline of HBV DNA levels started from treatment onset to week 4, and sustained in a low level since week 12. Forty-four (33%) of the 135 telbivudine-treated mothers and none (0%) of the untreated controls had polymerase chain reaction-undetectable viremia (DNA <500 copies/ml) at delivery. Seven months after delivery, the incidence of perinatal transmission was lower in the infants that completed follow-up born to the telbivudine-treated mothers than to the controls (0% vs. 8%; p = 0.002). HBV DNA levels were only detectable in HBsAg+ infants. No significant differences in anti-HBs levels were observed during postnatal follow-up. No serious adverse events were noted in the telbivudine-treated mothers or their infants. Conclusions: Telbivudine used during pregnancy in CHB HBeAg+ highly viremic mothers can safely reduce perinatal HBV transmission. Telbivudine was well-tolerated with no safety concerns in the telbivudine-treated mothers or their infants on short term follow up. These data support the use of telbivudine in this special population. © 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.


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ModLoaderMP 1.0.0 Minecraft 1.0.0
ModLoaderMP 1.0.0 – Download ModLoaderMP for Minecraft 1.0.0. Looking or ask for ModLoader MP? this mod is very popular because some people need it to install another mod right? So many people have asked how to make SMP mods that I decided to write down all I know in a nice organised tutorial. This tutorial assumes that you have made ... Read More »
BackPacks Mod 1.10.2/1.9/1.8
BackPacks Mod – Download BackPacks Mod for Minecraft. Do you know about this mod ? the BackPacks mod is mod where you can adds the ability to have a portable inventory chest, allowing you to carry a lot more items. This is one of my favorite mods and now has working fine with latest minecraft. Want to download and install ... Read More »
Smart Moving Mod 1.8.9/1.8/1.7.10
Smart Moving Mod – Download Smart Moving Mod for Minecraft. Well amazing mods has been update again and now work fine with your latest minecraft. This mod implements an optional mode of free climbing behaviour. When enabled by configuration or by default you can climb everywhere you find at least a block sized horizontal edge. The Smart Moving mod gives ... Read More »
Animal Bikes Mod 1.8.9/1.8/1.7.10
Animal Bikes Mod – Download Animal Bikes Mod for Minecraft. Well guys, today i'll post about one of my favorite mods called Animal Bikes mod. This is Mod can gives you the ability to ride all the animals, NPC's including the enderman and dragons, plus many more. If you want to install this mod Be sure you followed the installation ... Read More »


text:
Stoic The Duke Glove
Retailers' Descriptions
Here's what other sites are saying:
Your baby girl stubbornly refuses to nap in her crib, so you have no choice but to pull on the Stoic Women's Thrive Aurora Pant, bundle her into the jogger, and hit the road. The Aurora's heavyweight four-way-stretch fabric delivers supportive comfort as you traverse the familiar running trail pushing the jogger with the sleeping baby. It also dries quickly, which is fortunate since Her Highness will probably be awake by the time you get back to the house, and you will be too busy waiting on her to change clothes until bedtime.
- Backcountry.com
Stoic The Duke Glove
$17.99 - $27.50
The Duke Glove has been discontinued.previously retailed for:
$17.99 - $27.50
The Stoic The Duke Glove is not available from the stores we monitor. It was last seen February 22, 2016 at Backcountry.com.
If you're looking for a new insulated glove/mitten, check out the best reviewed current models.


text: Set against the backdrop of Chicago's residential neighborhoods, streetwear store Saint Alfred in collaboration with Stussy has just released its "Windy City Tribe" capsule collection. The capsule features a crewneck sweater emblazoned with Saint Alfred Chicago across the chest, a coach jacket with Windy City Tribe across the back, and a selection of headwear. The line will be available starting today at Saint Alfred and KICKS/HI before launching Saturday, March 29 on Stussy.com and selected Stussy Chapter stores.