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For more than two centuries, the U.S. House of Representatives has carefully crafted rules and procedures to help it function as the legislative body that the Founders envisioned—"the People's House." Some practices are rooted in the U.S. Constitution; others are traditions adopted to meet the changing needs of the nation and the institution. Learn about the House's role, powers, and development by exploring essays, Congress-by-Congress summaries, and profiles about the House's unique culture.
Since 1920, the Clerk of the House has compiled and published the official vote counts for federal elections from the official sources among the various states and territories.
This section provides data about a Member's service in the House of Representatives.
View a chart of House political party divisions since 1789.
View a list of House vacancies and successors from the 105th through the 113th Congresses (1999–2015).
View a chart with the dates the House has been in session, from 1789 to the present.
View a chart with the dates the House has been in session from, 1789 to the present.
Established in Article II, Section 1, of the U.S. Constitution, the Electoral College is the formal body which elects the President and Vice President of the United States. Learn about the procedure and a few historic facts about this process.
View a chart of the 44 U.S. Presidents and Vice President terms with their corresponding Congresses.
View a chart of the Presidents of the United States and the number of veto messages each issued.
For more than a century, seat assignment in the U.S. House of Representatives was an important element in congressional life. Until the early 1900s, when benches replaced them, a desk was a Member's office. How Members secured a desk evolved from free-for-all to highly orchestrated political theater.


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Quality Hotel Prisma is a modern conference and family hotel located in the heart of Skövde. It is centrally located by Boulogner Park and within walking distance of Skövde travel centre, the main shopping street and restaurants.
The conference facilities at Quality Hotel Prisma place the actual thought process in focus. This is where the best ideas are born, promoted and realised.
Our staff help you with the planning so that your conference is as effective as possible. They deal with everything from great lighting and furniture to food and drink. Anything to provide our conference guests with the ideal environment to get the creative juices flowing.
Let's start with a promise of something more than bad coffee, dry pastries and boring decorations. We'll do a bit more than that – and that's a promise!
For more information or a quote, please do not hesitate to contact us on +46 500 48 80 00 or at email@example.com.
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subset: commoncrawl


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Responsive website - Already have the design!
This project received 22 bids from talented freelancers with an average bid price of $33 USD.Get free quotes for a project like this
Skills Required
Project Budget$10 - $30 USD
Total Bids22
Project Description
Hey everyone!
I need someone who can get my website to look good on Safari, Firefox, Chrome, iOS, Android and all that jazz.
Making it responsive and manageable on all devices and browsers!
A simple task that shouldn't take more than one-two hours. Giving me a good result will lead to future website related tasks and project where the person will be my ''go-to guy''
Good luck!
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UPDATE: Prosecutor classifies death as "suspicious" and says further tests needed to determine cause of death.
A Jersey City man with bruising on his face was pronounced dead on arrival to the Jersey City Medical Center, according to police reports.
James Robinson, a 48-year-old man living at 337 Martin Luther King Dr., was brought to the medical center at approximately 8 p.m. last night after an ambulance was dispatched on reports of a male who wasn't breathing, reports said.
The report states that Robinson needed to be revived due to cardiac arrest, but was pronounced dead at 8:39 p.m.
According to the report, police were called to the hospital to investigate the bruising on Robinson's face.
Hudson County Prosecutor Edward DeFazio said the death was ruled as suspicious, but is not considered a homicide pending results of the autopsy.


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School of Medicine
Showing 1-10 of 25 Results
Kim Walker
Manager, Instructional Design and Production, SoM - Information Resources & Technology
Current Role at Stanford Kim is an Instructional Designer in the School of Medicine. She consults with SoM faculty to design and develop online courses for Continuing Medical Education. Kim holds a Ph.D. and M.Ed. in Curriculum and Instruction with an emphasis in Instructional Design and Science Education from the University of South Florida. Her undergraduate degree is in biology from the University of Colorado. She formerly worked for Stanford Health Care as a Program Manager and Education Specialist in Graduate Medical Education.
Specialties: instructional design; online education; medical education; residency education; secondary and adult education; health care; higher education; mixed methods research; qualitative research
Shannon Walters
Co-Manager, 3D and Quantitative Image Laboratory, Radiology - Diagnostic Radiology
Current Role at Stanford 3D Technologist at 3DQ Laboratory. I am very much involved in improving and developing new processing methods and protocols. Additionally I have been implementing many technological changes which minimize our footprint and streamline our workflow. Examples of how this is being done are promoting a server-based strategy for workflow and consolidating non-server functions into fewer PCs. The non-server functions are almost all available from any PC through VNC clients which essentially has made everything operate like a server-based system (with the exception of only 1 user at a time).
The future of the 3DQ Lab might include the ability to do everything from remote locations as well.
Ronald D. Watkins
Senior Research Engineer, Rad/Radiological Sciences Laboratory
Current Role at Stanford My current position is Senior Research Associate in the Radiological Sciences Laboratory in the Department of Radiology at Stanford School of Medicine. I provide hardware, systems, and general technical support for a group of 10 Faculty members and many students and post docs in the development of advanced medical imaging and image guided interventions. My training background is primarily in RF and electrical engineering and I spent more than 25 years in the commercial diagnostic imaging industry. Most of the projects I am currently working on involve high field MRI (3 Tesla and above), Magnetic Resonance Guided Focused Ultrasound, and other hybrid systems involving ultrasound imaging, therapeutic ultrasound or positron emission tomography combined with MRI. I have ongoing collaborations with many other medical research institutes and Universities around the world. I currently have 39 issued US patents
Susan Weber
Director, Informatics Services, SoM - IRT Research Technology
Bio Susan C. Weber, PhD is Director of Informatics Systems and Software Development for the Stanford Center for Clinical Informatics. Dr. Weber has been a member of the STRIDE project team since its inception, and is the principal developer of many of STRIDE's core systems. Dr. Weber has a PhD in Computer Science and 20 years' experience as a professional software developer.
Wu Wei
Senior Research Scientist, Biochemistry - Genome Center
Current Role at Stanford Senior Research Scientist, Group Leader in Bioinformatics, Stanford Genome Technology Center, Stanford University
Yingjie Weng
Biostatistician, Surgery
Current Role at Stanford Biostatistician
- Implement protocol for quality control
- Create analytic files with detailed documentation
- Implement data analysis through statistical programming
- Present results for investigators by graphs and tables
- Summarize finding orally and in written forms
- Participate in preparations of papers for publication
- Assist with grant preparation


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Fallout: New Vegas
Possible Endings (Spoilers)
darkus37 posted on Oct 26, 2010 11:18:59 AM - Report post
Hi, I was wondering if someone can post the possible decisions/endings that are shown in the final cutscenes. For example: Helping the doctor find a cure for the nightkin causes the nightkin to stay in Jacobstown. In particular, I am wondering about the Great Khans, if I convince the advisors and through them Papa Khan, the Khans leave and form their own empire. What happens if I kill Papa Khan and have Regis instead join up with the NCR?
KellionBane posted on Oct 26, 2010 1:14:34 PM - Report post
darkus37 posted on Oct 26, 2010 2:11:28 PM - Report post
Page 1 of 1
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Game Review
Our review, including how cheats factor into the gameplay and affect the overall experience.
Latest Trainer
• Unlimited Health
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Course Directory: United States / Tennessee / Sparta
Sparta, Tennessee Golf Courses & Discount Tee Times
Whether you're visiting Sparta, Tennessee for business or recreation, make a round of golf one of your top priorities. Sparta, Tennessee has many outstanding options for the avid golfer, including a wide variety courses and plenty of tee times to fit your schedule. Plan to play a new course during your stay in Sparta, Tennessee and take advantage of the incredible deals on tee times available through GolfNow.
All Sparta, Tennessee Golf Courses
RiverWatch Golf Club
18 holes over 6850 yards with a par of 72235 Harbour Greens Pl
Sparta, TN 38583-4282
Sparta Golf & Country Club
9 holes over 2759 yards with a par of 35129 Lester Flatt Rd
Sparta, TN 38583-2518


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U-Pic-A-Part Blog
St. Louis
, which opened on October 15, 2013, brings a whole new concept of parts-buying to the
St. Louis area
. We are a self service used
auto parts yard
, so you, the customer, actually pull the part. By doing so, you can purchase the desired part at a significant savings. While this is not a new concept, it is new to the St. Louis market.
We are family owned and operated and our friendly sales staff is bilingual. St. Louis U-Pic-A-Part has over 3,000 used cars, trucks, and vans to choose from and we rotate our vehicles every day to ensure fresh inventory. We have the largest inventory of used auto and truck parts in the St. Louis/East St. Louis area. All parts carry a 45 day FREE exchange warranty with the original receipt. No cash refunds.
In addition, we provide interchange for the year, make, and model of the vehicle that you own. Our entire inventory is placed on stands for the convenience of our customer, so all you have to do is bring your own tools and pull the parts you need. Not only does St. Louis U-Pic-A-Part sell used parts from cars, trucks, and vans, but we also buy junk vehicles and scrap and pay top dollar IN CASH. Be sure to bring your clunker by St. Louis U-Pic-A-Part and receive cash for your vehicle today. We do require a title with each vehicle!
Conveniently located next to the Hollywood Night Club at 6111 Bunkum Road in Washington Park, IL, St. Louis U-Pic-A-Part is open daily from 8:00 a.m. - 6:00 p.m. We are open seven days a week for your convenience and are only closed on Christmas and Thanksgiving. Yard admission is only $2.00, while active Military in uniform or with a Military ID will be admitted for FREE. Must be at least 16 years old to enter yard. Thank you for visiting our website and we look forward to serving you in the very near future!!!


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I'M A BIG believer that college is the time to find yourself - not Mr. Right.
So when I heard that a Princeton University snob had written an op-ed in the school newspaper urging that female coeds need to find husbands before they graduate, I was, like, oh no she didn't.
Addressing "the daughters I never had," 1977 grad Susan A. Patton wrote, "For most of you, the cornerstone of your future and happiness will be inextricably linked to the man you marry, and you will never again have this concentration of men who are worthy of you. Here's what nobody is telling you: Find a husband on campus before you graduate. Yes, I went there."


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Have you visited Dr. Gertrudes Montemayor? Rate you experience below.
Family Practice Physicians in Folsom, CA
Dr. Gertrudes Montemayor specializes in family practice, internal medicine in Folsom, California.
Dr. Gertrudes Montemayor has been compared 89 times. Details of Dr. Montemayor's 25 years experience as an MD, her hospital affiliation and education at University of California are available on your free doctor report.
Dr. Gertrudes Montemayor has an average rating of 4 stars (out of 5) with a rating of Very Good based on 3 reviews.
Have you visited Dr. Gertrudes Montemayor? Rate you experience below.
Dr. Gertrudes Montemayor has been identified as specializing in Family Practice and Internal Medicine.
Insurance plans and networks accepted by a doctor are not necessarily universal across all locations at which the doctor practices. This can be affected by many factors such as different group practices, hospital affiliations and working arrangements at those locations. Checking that the doctor you are visiting and the facility they are at are in-network providers for your insurance plan can save you money and headaches later from surprise medical bills.
Dr. Gertrudes Montemayor accepts the following plans at 251 Turn Pike Dr, Folsom, CA
See additional insurance networks accepted by Dr. Montemayor
A hospital affiliation covers any doctor who has an affiliation, association or admitting privilege with a hospital. A doctor's particular affiliation to a specific hospital can translate to the overall quality of that provider.
Dr. Montemayor is affiliated with 1 hospital:
Dr. Montemayor attended medical school at University of California Davis School of Medicine and graduated in 1991 having 25 years experience.
While there is no proven correlation between the quality of one's educational institution and the quality of one's professional competence, it is often an indicator. Medical schools have various levels of selectivity (some are harder to get into than others), and both the quality of their clinical training and level of research are measured. Additional medical training in both residency and fellowships and the facilities they are conducted at also provide a history of the doctors' level of training and experience.
Patients may also know Dr. Gertrudes Montemayor MD as:
1600 Creekside Dr, Suite 1400 Folsom, CA 95630
1600 Creekside Dr, Suite 2100 Folsom, CA 95630
1700 Prairie City Rd, Folsom, CA 95630
2155 Iron Point Rd, Folsom, CA 95630
1700 Prairie City Rd, Folsom, CA 95630
Are you Dr. Gertrudes Montemayor?
Update your information


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Ratings based on 278 Verified Reviews
They paid and stayed. We double-checked.
4.7 Room cleanliness
4.5 Service & staff
4.5 Room comfort
4.5 Hotel condition
Expedia Verified ReviewsThey paid and stayed. We double-checked.
by Diana from Madison, WI, USA
Not for the older crowd.Posted Nov 11, 2012
Pros: The food was very good.
Cons: Constant loud music.
Location: Location and beach were beautiful.
We were disappointed that it became a Hard Rock Hotel. The loud music was everywhere all day long. We couldn't even hear the ocean and it lacked the peace and calm we were looking for. We booked as "Cancun Palace" but when we got there it was "Hard Rock Hotel". This is fine for people that want that kind of experience, but we wanted something more restful and subdued. The beach was beautiful, but again loud music was blasted day and night. Our sense of calm was assaulted. I'm not sure why they wanted to take a beautiful natural beach and blast out our eardrums. I feel the music could have been kept inside a nightclub area and people wanting that experience could have it, while the natural setting could have been kept subdued and natural. They also started adding upcharges to everything from the trips to shopping.
by Lory from New York, NY, USA
Great place for your familyPosted Sep 10, 2012
Pros: The service, the food, the pool, the beach
Cons: N/A
Location: exceptional
The hotel is beautiful, clean, good service and nice a ambiance. Perfect to go there with your family.
by Isaac
PESIMO SERVICIO DEL HOTELPosted Aug 29, 2012 on Hotels
Hotel con muy buenas instalaciones y comida. Fuera de eso el hotel presta un pesimo servicio a nuestra llegada habia un condon en la habitación, los toma corrientes no servian, el servicio de wi fi es pesimo, durante 2 dias no cambiaron las toallas de la habitacion, en la piscina un día no se conseguian toallas, la caja fuerte no funcionaba.
by F.S. from Orange County, CA
I would not recommend this hotel for families.Posted Aug 12, 2012
Pros: Japanese restaurant.
Cons: Too noisy.
It is not family type resort. The hotel was too noisy, drunk people screaming in hallway in the middle of night. The resort did not offer much of activities for all ages or decent entertainments at night. There were not enough towels or extra blanket in the room; the room was not cleaned until late afternoon. There were flood on the floor and leaky sealing.
by A verified traveler
Hold off on staying at this hotelPosted Jul 16, 2012
Pros: Variety of food, beautiful beach and kids club
Would have been nice to have been told that the hotel was in the middle of being changed to the Hard Rock hotel. But apparently no one thought it was important for us to be notified. The construction, painting, noise, and smell from new paint put a damper on our vacation. The check in process took too long despite the fact that we arrived in the evening. The keys wouldn't work and to get them recoded took over 20 minutes. The lobby was full of smoke, hot and stuffy from the Brazilian restaurant. The kids club, however, was great.
by Laurie from CT
super place to vacation after the construction!Posted Jul 7, 2012
Pros: the staff and the food!
Cons: construction and the STRONG ARMING to buy into the time share!
Location: just bautiful!
Unfortunatly the hotel is under going a major renovation to change over to a Hard Rock hotel, lots of construction, one of the pool bars was closed and tile work was being done, the tile saw was a bit much all day long. But the staff was super, and the food and drinks the best! most annoying is the constant PUSH to get you to join the club and become a member of the hotel chain!
by Eduardo
Excelente hotelPosted Jun 25, 2012 on Hotels
Mesmo em reforma para entrar na rede Hard Rock Hotels, a hospedagem foi muito boa. Forneceu bônus que você pode trocar por passeios/viagens, massagens, jantar romântico, up grade de quarto. O quarto amplo e lindo. Internet free sem fio. Café da manhã é muito bom. Alimentação é boa, as bebidas nem tanto (cerveja quente, refrigerante sem gás, sem carta de opções dos destilados, sem sucos naturais nas refeições, somente no café da manhã). Gostamos muito e recomendamos.
by A verified traveler
Great food and drink for a construction sitePosted Jun 24, 2012
Pros: Food & Drink
Cons: Unfriendly/unhelpful front desk Construction, Construction, Construction
Location: Under construction
My wife and I stayed three nights at Cancun Palace following three nights at the Valentin Imperial Maya (which is amazing BTW). The reason for splitting our trip was to attend a friend's wedding at Cancun Palace. Check-in and check-out were chaos. Expect to wait in a long line in close proximity to an area of the hotel that is very noisy. This left us with a bad first and last impression. By default they expect you to attend a timeshare presentation. We had to explain why we would not be attending the presentation. Our room was pretty nice, but was surrounded by rooms that were under construction. The sounds of construction made for a great alarm clock that lasted all day. Also, our hot tub didn't work and the front desk was unwilling to move our room. Construction was noticeable in nearly every area of the hotel. Several areas of the hotel were closed including pools and swim up bars. On a positive note food and drink were very good. Also, most of the service (absent the front desk) was very good. Lastly, they have an unexplainable protocol for airport transfers. Despite providing all of the relevant information at the time you make your transfer reservation – you must re-confirm your transfer reservation in person two days before departure. In summary, this place isn't all that bad - but we've had better and for slightly less money. I guess we'll re-consider this property when we have kids. Hopefully, they'll be done with construction by then!
by A verified traveler from Minneapolis, MN
Better than expectedPosted Jun 20, 2012
Just returned from a week at Cancun Palace with my wife and 4 kids (15, 12, 10, 8) and had a great time. They just finished the lobby bar but there is still some construction going on. It's not obtrusive and none of it affected our stay. Positives were the room (family deluxe, good size, clean, and reasonably quiet, the restaurants (Ciao was my favorite), the beach (clean and the waves great), the pool. The entertainment was average but I wasn't expecting much. The Magician was very good, the fire show was just ok. The mama mia show was poor (lip synching mediocre dancers). I didn't bother with the elvis show or the mexican night. My main negative was the transport company (Best Day), the guy at the hotel organizing the return shuttle was useless and didn't show up for multiple meeting times. eventually the hotel concierge sorted him out. The only other small negatives was pushing the time share at the check-in and exit and the whole resort credit thing which I thought was a waste of time. Anyway, those are small negatives and didn't affect my experience in any way. Overall, I had a great time. The kids loved the beach and the pool. the food and accommodation were better than expected. I think it's a great spot for families looking for a relaxing vacation. The Hard Rock renovations look nice and none of the construction affected my stay. Five stars!
by Grace from Atlanta, GA, USA
Be carefulPosted Jun 14, 2012
Pros: The beach..
Cons: The fact that a lot of Hungary are closed do to the remodeling and no specail acomodations.
Location: Great location
The hotel was 50% closed it was under remodeling we were cheated and it's not nice to be awaken by a pinging noise from a hammer. They should tell gets so they can choose to stay in a hotel that is under construction and has 50% of the hotel closed . The only good out of the hotel was the bartender Alvaro he went out of his way to welcome us. Don't buy there time share legendary is a rip off.


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G2D Games
Most Played Games
New Games
Dressup Games
Makeover Games
Girls Games
Celebrity Games
Cool Games
Cooking Games
Baby Games
Fun Games
Game Name
Scrawl Adventures
Fun Games
Game Tags
Click Here to Play
Game Details :
Do you like to paint? Well if you do, this is your game, because now you can choose the picture which you like and click the OK button. After you choose your favorite picture, choose pot, paint, brush to scrawl the wall but be aware because you can't be caught by police. Be careful because when the bird beside the blond girl jumps, tells you that the police is coming soon. Then, you have to stop scrawling!! Make sure that you don't get caught and good luck!!
New Games
Fashion for Spring
Pedicure Fashion Spa
Summer Time Outfit
Aqua Dress Outfit
Designer Leather Fashi
Beauty Hollywood Cuts
Sleeveless Fashion
Beauty Day Spa
Celebrities Beauty Sal
My Home Collection
Beauty Trends
Marriage Proposal


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Registration by donation open until 7:30 pm Pacific time tonight – the call begins at 8 pm Pacific.
Read the details and register via PayPal at this link.
Tom Jacobs is an Evolutionary Astrologer, Medium, and Channel helping you understand and do what your soul came here to do and give you insights into and tools for healing and making it happen. Ten books and two original natal reports are available through tdjacobs.com.


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My Trip: West Indies
Who: Paul and Rita Schmitt, of Erie
Where: West Indies
When: Dec. 7-14
What they said: We enjoyed a cruise on the Royal Clipper; at 400 feet, it is the world's largest square-rigged sailing ship. Our first evening onboard, we were on the upper deck as the crew prepared to "sailaway" from Barbados bound for the Windward Islands. What a surprise when music started playing as the sails on all five masts were slowly raised. The music perfectly fit the mood of a sailing ship leaving port.
We sailed to a new island each night. Shore excursions were available or you could just spend the day on the beautiful, white-sand beaches. We did a Segway tour on St. Lucia and snorkeled on St. Kitts and Antigua, with manta rays! On Dominica, we helped prepare and eat a Creole lunch. At Isle des Saintes and Martinique we were immersed in their French heritage, because all signs and conversations were in French.
All week we had lots of sun and temperatures in the 80s. Humidity was low because of the trade winds. "Sailaways," especially when we left at sunset, were the highlight of our days. At night, the stars and moon were clearly visible. Too soon we were back in Barbados and our romantic high-seas adventure was over.


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Collins pic takes 14 nominations
LONDON — "Kings," Ireland's first ever submission for the foreign-language Oscar, heads the nominations for this year's Irish Film & TV Awards with 14 nods.
"Kings," directed by Tom Collins, is competing for the best film prize with "Becoming Jane," "Closing the Ring," "Garage" and "Shrooms," which were all shot in Ireland.
In the separate category of best international film, the nominees are "Atonement," "The Bourne Ultimatum," "La Vie en rose" and "The Lives of Others."
The IFTAs, now in their fifth year, are designed to recognize Irish talent working in local or international movies and TV shows.
Lenny Abrahamson and Mark O'Halloran confirm their status as the hottest director/writer team in Ireland, with 11 for their movie "Garage" and five for their TV drama "Prosperity."
Showtime's series "The Tudors," which shot in Ireland, leads the TV noms with eight.
The winners will be announced Feb. 17 at a ceremony in Dublin's Gaiety Theater.


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Posted on May 14, 2014 in Meet the Playtesters
Tiffani vs. Spencer
Posted on December 26, 2012 in Racquets
It's time to say goodbye to another year and time to say hello to all the year-end "Best of" lists. So not to be outdone, we're rolling out our list of Best of 2012 product lists. Once again the playtesters put on their thinking caps to come up with these favorites. We would love to […]
Posted on May 12, 2011 in Racquets
Snauwaert Vitas Gerulaitis
[gallery link="file" columns="4"]


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BRIGHTON, Colo. -- Ashley Eldridge was in a vehicle when a tornado appeared outside of her window near Brighton. She started shooting video of it with her cell phone video and emailed it to FOX31 Denver.
She wrote in her email, "Very close call."
She wasn't kidding. Watch her short video clip above.
And then check out the one below of the same tornado. It hit Petrocco Farms in Brighton late Monday afternoon.
Anthony Petrocco shot the video of the tornado as it ripped up some of squash on the farm. It's located just west of U.S. Highway 85 between east 136th and 144th avenues.
Visit Petrocco Farms' website.
See details about Monday's wild weather here.
The threat of very heavy rain and flooding increases dramatically for the next two days.


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Male Voice for 5 videos - american native speaker
This project was awarded to provideomaker for $31 USD.Get free quotes for a project like this
Awarded to:
Skills Required
Project Budget$30 - $40 USD
Total Bids12
Project Description
We need a US native speaker to record 5 videos (screen recording). The videos consist of short tutorial on how to open a trading account on a website of ours. 2-3 min per video max. This job can be done in 1h.
I will send the 5 videos (recorded my screen) I made myslelf + transcripts. Basically, I want the same videos returned to me but with US native speaker voice.
You will have to:
1. Watch the videos
2. Repeat the same on your computer
3. Record the screen while doing it and speak
4. Send it back to me
Happy bidding
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
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It's born, and it's a girl. I am the mother and Mr. Adobe Fireworks the proud father.
It is all vectorial, 2D and scalable to infinity :D
Full view: http://tinyurl.com/kawasaki-vulcan-1700
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Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
Copyright © 2009–2016 Dribbble LLC. All screenshots © their respective owners. Shipped from Salem, Mass. USA.


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All the latest horse racing form, betting odds, news, breeding, jockey and trainer information for SURVIVAL. SURVIVAL is a born in 16/08/2006 by Lonhro out of Belzero, trained by the PETER SNOWDEN stable.
The current race record for SURVIVAL is 3 wins from 13 starts with prizemoney of $61,710.00
*State exclusions apply to some offers. Please check T&Cs of each offer with the bookmaker.


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Milwaukee Irish Arts shines light on shameful past with 'Eclipsed'
In February, Ireland finally came clean regarding some very dirty laundry, admitting its long-standing role in aiding and abetting the existence of the notorious Magdalene laundries.
Ostensibly asylums for the reform of "fallen" women, these facilities enabled the Catholic Church to turn a tidy profit by using women - petty criminals, unwed mothers or simply young women deemed overly flirtatious or beautiful, in a country that has long associated women with sex and sex with sin - as a slave labor pool. The last one wasn't closed until 1996. »Read Full Article(4)
Day Two Reviews: Rich Homie Quan, Calvin Harris and more
Lollapalooza — in Chicago's Grant Park this weekend — is one of the few music festivals that has the potential to accelerate careers, and to put heavily hyped performers in their rightful place.
And that's rarely been as abundantly clear as on Saturday, when the day's big buzz act — rising Atlanta rapper Rich Homie Quan — was a bit of a bust. »Read Full Article


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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This review is from: G.SKILL Ripjaws X Series 16GB (2 x 8GB) 240-Pin DDR3 SDRAM DDR3 1600 (PC3 12800) Desktop Memory Model F3-1600C9D-16GXM
Pros: These assembled without a hitch, and work great!
I used them with my GIGABYTE GA-Z87X-UD4H motherboard.
Cons: N/A
Other Thoughts: Worth the price! It's always nice to have too much ramREAD FULL REVIEW
This review is from: CORSAIR CX-M series CX750M 750W 80 PLUS BRONZE Haswell Ready ATX12V & EPS12V Modular Power Supply
Pros: Set this up in my case without a problem. It's modular, which saved me a lot of trouble.
Cons: I would have a liked a bit more SATA data and power plugs, but this isn't worth an egg off.
Other Thoughts: It's Corsair, cheap, works well, modular, what else could you ask for?READ FULL REVIEW
This review is from: EVGA SuperClocked 02G-P4-2762-KR G-SYNC Support GeForce GTX 760 2GB 256-bit GDDR5 PCI Express 3.0 SLI Support Video Card
Pros: Works great, just as expected from EVGA.
Max out most games with no problem :)
Cons: None so far
Other Thoughts: Got a free game with it which is a pretty sweet deal if you ask me.READ FULL REVIEW


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At the movies
TINSELTOWN: "Raiders of the Lost Ark" on Sunday, 2 p.m., and Wednesday, 2 and 7 p.m. "Cloudy with a Chance of Meatballs" on Tuesday, 10 p.m. "Spirit of the Marathon" on Wednesday, 7 p.m.
Tinseltown: "The Internship." "The Purge."
MOVIES AT MEADVILLE: "The Internship." "The Purge."
Sunset Drive-In: "Epic." "Iron Man 3."
Tinseltown: "Mud."
Tinseltown: "This is the End."
MOVIES AT MEADVILLE: "This is the End."
"The Internship": Two salesmen (Vince Vaugn and Owen Wilson) whose careers have been torpedoed by the digital age find their way into a coveted internship at Google, where they must compete with a group of young, tech-savvy geniuses for a shot at employment. (1:59. PG-13 for sexuality, some crude humor, partying and language.)
"The Purge": A family is held hostage for harboring the target of a murderous syndicate during the Purge, a 12-hour period in which any and all crime is legalized. (1:25. R for strong disturbing violence and some language.)
"This is the End": While attending a party at James Franco's house, Seth Rogen, Jay Baruchel and many other celebrities are faced with the apocalypse in mega celebrity cast comedy. (1:47. R for crude and sexual content throughout, brief graphic nudity, pervasive language, drug use and some violence.)
"After Earth": A crash landing leaves Kitai Raige (Jaden Smith) and his father Cypher (Will Smith) stranded on Earth, 1,000 years after events forced humanity's escape. With Cypher injured, Kitai must embark on a perilous journey to signal for help. Kind of flat and boring. (1:40. PG-13 for sci-fi action violence and some disturbing images.) *1/2
"Epic": A teenager finds herself transported to a deep forest setting where a battle between the forces of good and the forces of evil is taking place. She bands together with a ragtag group characters in order to save their world -- and ours. Not the most epic story or animated movie, but not a bad flick for kids. (1:42. PG for mild action, some scary images and brief rude language.) **1/2
"Fast & Furious 6": Agent Luke Hobbs (Dwayne Johnson) enlists Dominic Toretto (Vin Diesel) and his team to bring down former Special Ops soldier Owen Shaw (Luke Evans), leader of a unit specializing in vehicular warfare. Don't worry about physics or substance. Just enjoy the ride. (2:10. PG-13 for intense sequences of violence and action and mayhem throughout, some sexuality and language.) **
"The Great Gatsby": A Midwestern war veteran (Tobey Maguire) finds himself drawn to the past and lifestyle of his millionaire neighbor (Leonardo DiCaprio). DiCaprio gives a mesmerizing performance. (2:23. PG-13 for some violent images, sexual content, smoking, partying and brief language.) ***
"The Hangover Part III": This time, there's no wedding. No bachelor party. What could go wrong, right? But when the Wolf Pack (Bradley Cooper, Ed Helms, Zach Galifianakis) hits the road, all bets are off. Short on the usual "Hangover" raunch and laughs, which makes this sequel pretty forgettable. (1:40. R for pervasive language including sexual references, some violence and drug content, and brief graphic nudity.) **
"Iron Man 3": When Tony Stark's (Robert Downey Jr.) world is torn apart by a formidable terrorist called the Mandarin (Ben Kingsley), he starts an odyssey of rebuilding and retribution. Fun and cute, although sometimes long winded. (2:10. PG-13 for sequences of intense sci-fi action and violence throughout, and brief suggestive content.) ***
"Mud": Two teenage boys encounter a fugitive (Matthew McConaughey) and form a pact to help him evade the bounty hunters on his trail and to reunite him with his true love. McConaughey gives a great performance in this sweet, touching and engaging drama. (2:10. PG-13 for some violence, sexual references, language, thematic elements and smoking.) ***
"Now You See Me": An FBI agent and an Interpol detective track a team of illusionists who pull off bank heists during their performances and reward their audiences with the money. Stars Jesse Eisenberg, Mark Ruffalo, Isla Fisher and Woody Harrelson. Interesting, but the movie ends up with a disappointing finale. (1:56. PG-13 for language, some action and sexual content.) **
"Star Trek Into Darkness": When Capt. Kirk (Chris Pine) and the Enterprise crew come up against a traitor (Benedict Cumberbatch) and a weapon of mass destruction, they embark on a dangerous manhunt to a war-torn planet. It's not perfect, but director J.J. Abrams gets pretty close to it with a fun, action-filled sequel. (2:12. PG-13 for intense sequences of sci-fi action and violence.) ***
SOURCES: Reviews are excerpted from wire services. Previews are courtesy of the Internet Movie Database.
RATINGS: The Motion Picture Association of America ratings are G for general audiences; PG parental guidance because of material possibly unsuitable for children; PG-13 parents are strongly cautioned to give guidance for attendance of children younger than 13; R restricted, younger than 17 admitted only with parent or adult guardian; NC-17 no one younger than 17 admitted.
For more: Visit GoErie.com/showcase for all of the capsules.
NOTE: Schedules are subject to change. Check Showcase movie ads and online for late changes.


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The manifestations of age-related hearing loss (ARHL) in many older adults are subtle1—having to increase the volume of the television, missing words of a conversation—and hence, hearing loss is often perceived as an unfortunate but inconsequential part of aging. This observation is borne out by the epidemiologic data, which report that although 26.7 million US adults aged 50 years or older have a clinically significant hearing loss, fewer than 15% use hearing aids.2
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My son, 19months now, his circumcision didn't heal right. Instead of the skin healing to the shaft of the penis it healed to the rim of the head. His pediatrician said that we had to give him a bath and after each bath to pull the skin and tear it away from the head. I tried doing this several times and each time I did it he would start to scream so I would stop. Yesterday we took my 4 month old to the pediatricians to get his shots, and I brought it up to the Doctor that my 19 month olds penis was still the same as his last visit. He took a look at him and said that the skin had to be pulled away other wise it was going to get infected. DH held him down while the doctor pulled the skin away. I have never heard my son scream the way he did that day. The other pedi came in to clean his penis, she told us that her son had the same thing and that it's better to do something while there young then to wait. She told us that if we would've left it sex for him would be extremely painful. Ever diaper change I have to clean his penis. It's really red and he screams,kicks, and tries to get away. I feel so bad that this happened to him. I know it's traumatic for him, and it's traumatic for DH and me too.
I was just wondering if this happened to anyone else? If it's rare? I just don't want to feel alone in this. I feel horrible when I have to change his diaper, but it has to be done so infection doesn't set in. I feel like a horrible mother. I should have prevented this from happening.


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Randy Shaw: Joe Biden gave the type of debate performance that, if given by Barack Obama last week, would have ended the race. Obama supporters can only hope that the President was carefully taking notes.
The Polarizing Political Paradox Redux
Claude Fischer: Political scientists have long established that most Americans cannot reliably identify which specific policies each party supports, that people adopt party loyalties quite early in life, and that most stick to those loyalties whatever happens.
Santorum and Satan: Three Speeches
Steve Hochstadt: I believe in Kennedy's America. Not in Rick Santorum's, where those who do not agree with him have been captured by the Devil.
Top 10 Most Read Led by "Blaming Schools and Teachers"
Topping this week's list is, once again, Mark Naison, the Fordham University professor and editor of With a Brooklyn Accent, who writes so passionately on issues of education and race..
Obama's No FDR, But He's Made the Case for a "New" New Deal
Ira Chernus: No matter who the Republicans nominate to run against Barack Obama, it seems clear that we'll have a kind of presidential contest we haven't seen in more than seventy-five years: a referendum on the government's proper role in economic life.
The Purpose Driven Cheat
It's amazing how much mud is flying in this presidential contest – and not just that which is being flung nonstop at Barack Obama. Mudslinging is common during political campaigns, but sometimes that mud isn't exactly a guided missile. There are moments when it's splattered about with such zeal that it just gets all over […]


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Rent Sex and Gender Hierarchies 1st edition today, or search our site for other textbooks by Barbara Diane Miller. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Cambridge University Press.
Need help ASAP? We have you covered with 24/7 instant online tutoring. Connect with one of our Gender-Studies tutors now.


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We welcome you in our new facilities in Holtagarðar Reykjavík.
Here you can see where we are located around Iceland. You can start your journey in Iceland in one rental location and return the car in another. How nice is that?
Present your driver's license at Avis counter, collect your keys and drive off to your adventure in Iceland and explore what it has to offer.
Here you can change, manage, or cancel your booking. You only need to enter your reservation number and your surname to change your reservation.
Iceland is a beautiful country but the travelling conditions can be fairly challenging. Be sure to familiarize yourself with the safety rules.
Your personal guide through the wonders of Iceland with the choice of three different day tours. Golden circle, the Reykjanes peninsula and the South shore.


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Like a Band-Aid floating in a public swimming pool, broadcast's new summer series are turning out to be a total bummer.
Of the nine new shows introduced thus far in the sleepy season, only one—Fox's The Choice—is averaging a 1.5 rating among adults 18-49. What's more, a few of the freshman efforts have failed to deliver so much as a 1.0 in the advertiser-coveted demo.
The plague of flops has spared no network, although ABC may be a bit more exposed than its rivals. The network has taken the wraps off three new series since the summer began—the singing competition Duets; The Glass House, which might charitably be described as an homage to CBS' Big Brother; and the true-crime strip Final Witness—and has another in the hopper (Trust Us With Your Life).
Leading out of four repeats Wednesday night, Final Witness bowed to 4.21 million viewers and a 1.0 in the demo, per Nielsen live-plus-same-day ratings. This marks the lowest-rated premiere for ABC this summer, as Duets arrived on May 24 with an audience of 6.76 million viewers and a 1.7 rating, while The Glass House drew 3.98 million viewers and a 1.5 rating in its June 18 debut.
Through its first five episodes, Duets is averaging 5.22 million viewers and a 1.3 in the demo. Given the star power on hand (the judges are the singers Kelly Clarkson, John Legend, Jennifer Nettles and Robin Thicke), those are disappointing numbers, even for a summer series. It's likely that viewers have had their fill of the musical-competition genre, given the ubiquity of established series like American Idol, The Voice, The X Factor and America's Got Talent.
The Glass House is in a deeper funk, having lost nearly 900,000 viewers and 27 percent of its premiere demo in its second week on the air. The June 25 installment scared up a mere 3.09 million viewers and a 1.1 rating.
ABC's top-rated summer series is The Bachelorette, now in its eighth cycle. Remarkably consistent, the heavy-breathing dating show is averaging 7.09 million viewers and a 2.3 in the demo, and is on track to deliver its highest ratings in three seasons.
The network can claim bragging rights to the summer's biggest draw, as the NBA Finals were the highest-rated five-game series since 2004. The Heat-Thunder showdown averaged 16.9 million viewers and a 7.1 in the demo, up 8 percent from the first five games of last year's pro hoops finals.


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Rajun' Cajun Ham & Broccoli Alfredo
Total Time
Prep 10 mins
Cook 25 mins
I had some leftover Easter ham and had some frozen broccoli in the freezer, so I based this recipe on Chef Lorac's Creamy Cajun Chicken Pasta (please try this when you get a chance its great). Be careful with this, it starts out as wonderfully mild sauce, but it sneaks up on you with the heat (at least it does for me :) Submitted on April 19th 2006.
Ingredients Nutrition
- 8 ounces cooked ham (roughly chopped)
- 6 ounces angel hair pasta
- 1 1⁄2 cups frozen chopped broccoli
- 2 teaspoons cajun seasoning (used Cajun Seasoning)
- 2 tablespoons margarine
- 1 cup heavy whipping cream
- 1⁄4 teaspoon salt
- 1⁄4 teaspoon dried basil
- 1⁄8 teaspoon ground black pepper
- 1⁄8 teaspoon garlic powder
- 1⁄3 cup grated parmesan cheese
- In a large pot of water, add broccoli and pasta; cook until pasta is at desired doneness.
- Drain and keep warm.
- In a large skillet, melt margarine. Add ham and Cajun seasoning.
- Stir until ham is well coated.
- Lower heat and add rest of ingredients except grated parmesan cheese; heat through.
- Pour over pasta and broccoli.
- Sprinkle with cheese and toss until pasta is coated.
Most Helpful
Good stuff Shapeweaver! My family loved this. Flavor was excellent, but mine was a little dry so next time I may double the sauce. It could be that I used too much pasta cause I eyeballed it....none the less we had a super meal!
This was really good! My dh and 2 sons and dd inhaled it, as did I! I just realized that I forgot all about the parmesan cheese, so next time, it will be even better!


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OSHA News Release - (Archived) Table of Contents
OSHA News Release – Region 10
U.S. Department of Labor
Region 10 News Release: 99-10
Monday, January 25, 1999
Contact: Jeannine Lupton, (206) 553-7620 | TDD: (800) 676-8956
SEATTLE - The U.S. Labor Department's Occupational Safety and Health Administration (OSHA) announced today it has issued a Willful citation and a Serious citation against Harp Line Constructors Company, based in Kalispell, Montana, carrying a total of $202,500 in proposed penalties for alleged job safety violations at a worksite in Boise at Oregon Trail and Surprise Way.
Ryan Kuehmichel, OSHA area director in Boise, said the job safety violations were the result of an inspection by the OSHA Boise Area Office after an OSHA compliance officer observed that a current construction project would become increasingly hazardous due to the convergence of many high voltage transmission lines into the Boise substation. Harp Line Constructors Co. and its subcontractor Winco, Inc., had previously been cited for violations of stringing procedures, including two involving fatal accidents.
Harp Line Constructors Co. was the general contractor used to install a conductive fiber optic cable. Winco, Inc., was subcontracted to Harp Line Constructors Co. to perform designated portions of the stringing operation using a helicopter.
Harp Line Constructors Co.'s Willful citation noted the following violations: the ends of grounds were not attached or removed by insulated tools; where work was to be performed at more than one location in a line section, the line was not grounded and short circuited at one location in the line section and the conductor being worked on was not grounded; electrodes being used did not have a resistance to ground low enough to remove the danger of harm to personnel or permit prompt operation of protective devices; bare conductors, subconductors, and overhead conductors were not grounded at the first tower adjacent to both the tensioning and pulling setup during stringing operations; when crossing over energized conductors in excess of 600 volts the line being strung was not grounded on either side of the crossover or considered and worked on as if the line was energized; guard structure members were not sound and of adequate dimension and strength or adequately supported; the grounds were not placed and removed with a hot stick, except for moving type grounds; and clipping crews and others working on conductors, subconductors or over head ground conductors were not protected by individual grounds installed at work locations.
The Serious citation noted the following violations: the truck crane boom was extended within the minimum prescribed approach distance to a 230kv energized transmission line; the truck crane was not provided with an equipment ground while working within the approach distance of energized lines; Guy Grip Dead Ends were used as pulling sock connections against the manufacturer's advice; and pulling equipment used for stringing conductors adjacent to energized lines was not isolated, insulated or effectively grounded.
According to Kuehmichel, the company has 15 working days to contest the citations.
Editor's Note:
A Willful violation is defined by OSHA as one in which an employer knew that a condition constituted a violation or was aware that a hazardous condition existed and made no reasonable effort to correct it.
A Serious violation is defined by OSHA as one in which there is substantial probability that death or serious physical harm could result, and the employer knew or should have known of the hazard.
The Boise OSHA area director may be contacted at 1150 North Curtis Road, Boise, Idaho 83706, telephone 208-321-2960.
|OSHA News Release - (Archived) Table of Contents


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Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs bind lipopolysaccharides, act as chemoattractants for immune cells and bind to cellular receptors and modulate the expression of cytokines and chemokines. These additional biological activities may explain the role of AMPs in inflammatory diseases and cancer. Modulating the endogenous expression of AMPs offers potential therapeutic treatments for infection and disease.
The present review examines the published data from both in vitro and in vivo studies reporting the effects of nutrients and by-products of microbial metabolism on the expression of antimicrobial peptide genes in order to highlight an emerging appreciation for the role of dietary compounds in modulating the innate immune response.
Vitamins A and D, dietary histone deacetylases and by-products of intestinal microbial metabolism (butyrate and secondary bile acids) have been found to regulate the expression of AMPs in humans. Vitamin D deficiency correlates with increased susceptibility to infection, and supplementation studies indicate an improvement in defense against infection. Animal and human clinical studies with butyrate indicate that increasing expression of AMPs in the colon protects against infection.
These findings suggest that diet and/or consumption of nutritional supplements may be used to improve and/or modulate immune function. In addition, by-products of gut microbe metabolism could be important for communicating with intestinal epithelial and immune cells, thus affecting the expression of AMPs. This interaction may help establish a mucosal barrier to prevent invasion of the intestinal epithelium by either mutualistic or pathogenic microorganisms.
Cathelicidins, defensins and other antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune system and play an important role in combating infection [1-4]. AMPs have two or more positively charged residues in acidic environments and can bind to the negatively charged membranes of both gram (−) and gram (+) bacteria, mycobacteria, fungi and enveloped viruses, which in turn kills the pathogens by disrupting their cell membranes [5, 6].
The human cathelicidin antimicrobial peptide (CAMP) gene encodes a preproprotein with an ~30 amino acid–long N-terminal signal sequence, a 94 amino acid cathelin domain and a 37 amino acid C-terminal cationic AMP domain (LL-37) [6]. The CAMP gene is primarily expressed in myeloid bone marrow cells, and the proprotein, hCAP18, is packaged in neutrophil specific granules [7]. CAMP is also expressed by epithelial cells in tissues exposed to environmental microbes, and the protein is secreted in semen, saliva and sweat providing barrier protection to mammals [8-10]. Mice and humans lacking CAMP are susceptible to bacterial infections in numerous tissues [4, 11, 12]. High circulating levels of hCAP18 are found in human plasma [13]. The hCAP18/LL37 peptide binds to and neutralizes LPS [14], thus preventing its interaction with the LPS-binding protein and subsequent activation of TLR-4 [15], NF-κB signaling and cytokine release from host cells [16]. LL-37 protects against LPS-induced sepsis in animals [17, 18] and kidney dialysis patients with low serum levels of hCAP18 are twice as likely to die from infectious disease or sepsis than patients with higher levels [19]. Therefore, circulating hCAP18 or LL-37 may protect against both bacterial infection and sepsis.
Like cathelicidin, defensins are expressed by immune cells and epithelial cells of tissues that are exposed to the environment [3]. Defensins have six highly conserved cysteines that form disulfide bonds [2]. Human defensins are classified into two families: α- and β-defensins [20]. All defensins are expressed as a biologically inactive preproprotein and activated by cleavage of a prosequence [20]. To date, six α-defensins have been identified with HNP-1–4 packaged in human neutrophil primary granules and HD-5 and HD-6 expressed by Paneth cells in the small intestine [3]; HD-5 is also expressed by epithelial cells of the female genitourinary tract [21]. The α-defensins have antimicrobial activity against a range of bacteria, viruses and fungi [20].
β-defensins are the most widely distributed of the antimicrobial peptides. They are typically 38–42 amino acids long [22] and expressed in monocytes, macrophages and dendritic cells (DCs) [23] as well as epithelial cells in the respiratory and urogenital tracts, skin and tonsil [20, 24]. Human β-defensin 1 (HBD-1) is constitutively expressed in many tissues while HBD-2, HBD-3 and HBD-4 expression is induced by inflammatory stimuli, such as bacterial infection, LPS, IL-1β, TNF-α or phorbol-myristate-acetate (PMA) [2, 3, 20, 22, 25]. β-defensins have shown activity against both gram (−) and gram (+) bacteria, fungi, viruses and parasites [26-28].
In this paper, we review the regulation of the CAMP gene and the defensin gene family by various nutritional compounds and/or microbial by-products of metabolism and discuss the potential importance of this regulation for human innate immune function.
There are two forms of vitamin D that humans can utilize: vitamin D2 (ergocalciferol) from fungi and vitamin D3 (cholecalciferol) from animal sources and synthesized in the skin [29]. Expression of the human CAMP gene is induced by 1,25(OH)2 D3 and its analogs in various cell lines and primary cells [30-32]. Vitamin D induction of CAMP is solely a human and non-human primate phenomenon [33, 34] due to a vitamin D response element (VDRE) located within a primate-specific retro-transposable element (Alu-SINE) found in the upstream promoter region of the CAMP gene [34].
In subsequent studies, it was demonstrated in vitro that Toll-like receptor (TLR) activation induced CAMP expression via a vitamin D-dependent pathway in macrophages [35]. In the proposed model, sufficient levels of circulating 25(OH)D3, the precursor to 1,25(OH)2D3, are required for induction of CAMP gene expression and production of adequate LL-37 peptide levels to effectively combat infection (Fig. 1a) [35]. Cathelicidin expression is also increased in keratinocytes via a similar pathway after skin wounding [36].
Interestingly, the vitamin D-mediated induction of CAMP potentially boosts antimicrobial activity against pathogens through direct killing by LL-37 and enhancing phagosome maturation [37]. In THP-1 and human primary monocytes, 1,25(OH)2D3 triggers the formation of autophagosomes and autophagolysosomes via a hCAP18/LL-37-mediated pathway [37].
The HBD-2 gene (DEFB4) was induced by 1,25(OH)2D3 through a VDRE in the promoter, but the induction was not as robust as that observed for the CAMP gene [30]. Also, the induction of the HBD-2 gene in macrophages requires TLR activation and the convergence of the IL-1β and vitamin D pathways (Fig. 1b) [38]. In vitro studies demonstrated that activation of intracellular pattern recognition receptor nucleotide-binding oligomerization domain protein 2 (NOD2) by its ligand muramyl dipeptide (MDP), a lysosomal breakdown product of peptidoglycan from both gram-negative and gram-positive bacteria, induced the expression of the HBD-2 gene [39]. More recently, 1,25(OH)2D3 was shown to strongly induce the expression of NOD2/CARD15/IBD1 in primary human monocytic and epithelial cells [40]. In the absence of 1,25(OH)2D3, the activation of NOD2 by MDP activates NF-κB and there is a modest induction of the HBD-2 gene; however, pretreatment with 1,25(OH)2D3 followed by MDP leads to a robust, synergistic induction of the HBD-2 gene (Fig. 1b) [40]. Activation of the vitamin D pathway alone is not sufficient to induce robust expression of HBD-2, and additional signaling pathways are required [38, 40]. Treatment of normal human keratinocytes with 1,25(OH)2D3 increased HBD-3 mRNA levels in a dose-dependent manner [41]. Interestingly, treatment of lesional psoriatic plaques with the vitamin D analog calcipotriol increased IκB-α protein levels inhibiting the NF-κB signaling pathway and blocked IL-17A-induced expression of HBD-2 in the plaques [42]. Down-regulation of HBD-3 was also observed in the lesional psoriatic plaques after treatment with calcipotriol [42].
Bile acids play an important role in digestion and absorption of dietary fat and nutrients by the digestive system. They bind to and activate many nuclear receptors and thus modulate metabolism. In humans, the two major primary bile acids are cholic acid (CA) and chenodeoxycholic acid (CDCA) [43]. CDCA binds to farnesoid X receptor (FXR) [44] and up-regulates cathelicidin expression (Fig. 1c) [45]. This regulation may contribute to the sterility of the bile duct.
Lithocholic acid (LCA), a toxic secondary bile acid, is a by-product of CDCA metabolism by bacteria in the colon. It is a low-affinity ligand for FXR, pregnane X receptor (PXR) as well as the VDR [46-48]. LCA binds to the VDR and significantly increases both human CAMP transcript and protein levels in human primary keratinocytes (NHEK) in a time- and dose-dependent manner [49]. In the human colonic epithelial cell line HT-29, LCA and butyrate act synergistically to induce human CAMP gene expression [50]. The LCA derivatives LCA acetate and LCA propionate induced expression of human CAMP more efficiently than LCA itself and were less toxic in tissue culture cells and mice, suggesting they are more potent VDR agonists and might be safer potential therapeutic agents than LCA [51]. Unlike LCA, the secondary bile acid ursodeoxycholic acid (UDCA) is not a ligand for the VDR, but rather increases the levels of VDR in the nucleus that, in turn, increases CAMP expression (Fig. 1c) [45].
Butyrate is a short-chain fatty acid produced in the colon by fermentation of dietary fiber by anaerobic bacteria. It is found in many foods, such as butter and cheeses, and is a histone deacetylase inhibitor (HDACi) [52]. Shigella infections down-regulate LL37 and β-defensin-1 levels in the colon of adult patients [53], and rabbit CAP18 levels in colon surface epithelium are reduced during Shigella infection; however, CAP18 can be restored after oral administration of sodium butyrate [54].
Because of its unpleasant smell, butyrate is rarely used in clinical trials and instead 4-phenylbutyrate (PBA), an odorless and palatable derivative of butyrate, is used clinically. In several human cell lines PBA up-regulates CAMP gene expression more potently than butyrate [55]. It was recently shown that PBA also counteracts the down-regulation of cathelicidin in both the colon and lung by Shigella in rabbits [56]. Furthermore, butyrate and its derivatives up-regulate transcription of cathelicidin in human colon epithelial cells [57] and synergistically induces human CAMP mRNA levels with 1,25(OH)2D3 in lung epithelial and myeloid cells [32, 55]. A chemical analog of PBA, α-methylhydrocinnamate (ST7), can also dramatically up-regulate human CAMP mRNA transcription [55]. These studies support a potential role for sodium butyrate and its derivatives in the treatment of human infections.
There are few publications reporting the regulation of defensins by butyrate; however, it has been shown to induce HBD-2 mRNA expression in colonocytes [58], and pretreatment of gingival epithelial cells with sodium butyrate significantly induced HBD-2 expression in response to bacterial challenge [59].
Sulforaphane (SFN) is a dietary HDACi found in cruciferous vegetables (e.g., broccoli and broccoli sprouts) that reactivates epigenetically silenced genes [60]. Recently, it was demonstrated that SFN induces HBD-2 mRNA and protein expression in the Caco-2 human colon cancer cell line in a time- and dose-dependent manner [58]. Inhibition of VDR by an antagonist significantly blocked the SFN-induced HBD-2 mRNA expression in these cells, and SFN treatment increased the expression of VDR in both Caco-2 and HT-29 cell lines, indicating that induction of HBD-2 by SFN was mediated by the vitamin D pathway [58]. Whether these observations were due to epigenetic changes was not examined. The MAPK/ERK and NF-κB signaling pathways were also involved [58]. It has not been determined whether cathelicidin expression is regulated by SFN.
Retinoic acid (RA) is a metabolite of vitamin A, which is important in several aspects of immune function [61]. The retinoic acid receptor (RAR) forms a heterodimer with the retinoid X receptor (RXR) and interacts with specific retinoic acid response elements (RAREs) in the promoters of target genes [62]. All-trans RA was shown to induce both porcine cathelicidin, PR-39 expression [63] and hCAP18 promoter activity [64]. In contrast, induction of HBD-2, -3 and -4 by Ca2+, TNF-α, IL-1β, INF-γ, PMA or Pseudomonas aeruginosa in human keratinocytes is inhibited by RA [65]. The promoter regions of all the inducible human β-defensin genes have several possible AP-1 binding sites [65], and RA may suppress the expression of these genes by antagonizing AP-1 (c-Jun/c-Fos)-mediated gene expression pathways [66]. Therefore, RA may impair the innate immune response in human skin, thus increasing susceptibility to infections during RA therapeutic treatment [65]. On the other hand, α-defensin HNP-1 was induced by both all-trans RA and 9-cis-RA in a dose-dependent manner, suggesting that retinoic acid may be important for myeloid cell expression of HNP-1 [67].
Increasing endogenous cathelicidin and defensin expression may be particularly useful in the treatment of infections. Clinical studies have shown that asthma patients have reduced hCAP18 levels [68]. High levels of circulating hCAP18 in hemodialysis patients at the beginning of their treatment was indicative of a significant decrease in 1-year mortality and there was a modest correlation with 1,25(OH)2D3 levels, but not with 25(OH)D levels [19]. In sepsis patients, lower 25(OH)D, vitamin D binding protein (DBP) and cathelicidin levels were associated with severe illness, and a positive correlation between 25(OH)D and cathelicidin levels was seen in all subjects [69]. Additional studies are needed to substantiate these latest findings and determine whether supplementation of vitamin D-deficient individuals with vitamin D or therapy with active analogs of 1,25(OH)2D3 would boost plasma levels of cathelicidin and thus increase the protection against infection and sepsis.
Supplementation may increase cathelicidin and defensin expression in tissues and immune cells, thus enhancing barrier function. Atopic dermatitis patients suffer from frequent skin infections; therefore, induction of CAMP expression in the skin may increase protection from infection [70]. Patients supplemented with 4,000 IU/d of oral vitamin D for 21 days showed increased cathelicidin expression in skin lesions and a mild increase in unaffected skin, but a decrease in skin infection was not determined [70]. Ex vivo infection of urinary bladder biopsies from post-menopausal women after vitamin D supplementation resulted in an increased induction of the CAMP gene and protein expression when compared to biopsies taken prior to supplementation [71]. The studies to date would argue that it is important for individuals to have sufficient serum levels of 25(OH)D to allow for the production of adequate levels of cathelicidin during infection.
Epidemiological studies link vitamin D deficiency and increased rates of respiratory infections and there is interest in using vitamin D supplementation to reduce influenza infections and treat tuberculosis [72]. In a small randomized trial of school-age children, the vitamin D-supplemented group showed a nearly twofold reduction in influenza A rates than in the placebo group [73]. In another study with participants from different racial groups, it was shown that the maintenance of serum 25-hydroxyvitamin D levels at 38 ng/ml or higher was correlated with a twofold reduction in the incidence of acute viral respiratory tract infections [74]. In a double-blind randomized control trial of tuberculosis patients starting treatment, vitamin D supplementation did not significantly affect the time that patient sputum cultures converted from positive to negative for Mycobacterium tuberculosis growth in the study population as a whole; however, a significantly shortened time of conversion was observed in a sub-group of participants with the tt genotype of the TaqI vitamin D receptor polymorphism [75]. The latter study demonstrates the importance that genetic differences among individuals may play in the outcomes of trials involving supplementation.
In contrast to the positive findings above, a number of negative studies with vitamin D have been reported. A randomized controlled trial of vitamin D3 supplementation showed that there was no obvious difference in the incidence and duration of severity of upper respiratory tract infections (URIs) between vitamin D (2,000 IU/day) and placebo groups although 25(OH)D level increased significantly after 12 weeks in the vitamin D group compared to the placebo group [76]. Another study found that there was no difference in serum 25(OH)D levels between groups of patients aged 1-25 months admitted to hospital with uncomplicated acute lower respiratory tract infection (ALRI) and healthy, similarly aged patients without a history of hospitalization for ALRI. This study suggested that vitamin D status was not a risk factor in hospitalization for ALRI [77]. In a randomized, double-blind, placebo-controlled trial in TB clinics, the intervention and placebo groups were given 100,000 IU of cholecalciferol or vegetable oil at inclusion and again at 5 and 8 months after the start of treatment, but no significant difference was observed between the groups on mortality in patients with TB [78].
Very recently, a randomized, double-blind, placebo-controlled clinical trial to determine the efficacy of sodium butyrate as an adjunct therapy with antibiotics in the treatment of shigellosis in patients was performed. Reduced rectal luminal content of inflammatory cells and pro-inflammatory cytokines, increased expression of LL-37 in the rectal epithelia and improved rectal histopathology as compared to the placebo group were evident [79]. Nevertheless, the efficacy of sodium butyrate treatment in clinical recovery was not observed as in studies with rabbits [54, 79]. Important differences between the animal and human studies included oral delivery in rabbits versus delivery by enema in the humans and the lack of antibiotics in rabbits [79]. It remains to be determined whether oral delivery of butyrate compounds would be more efficacious as the treatment would not be eliminated as quickly as it is with an enema due to repeated bouts of diarrhea [79].
Accumulating evidence demonstrates that nutrients and microbial by-products derived from the metabolism of dietary factors may play a critical role in modulating the innate immune response via regulation of AMP gene expression. The by-products of gut microbe metabolism are potentially important for increasing AMP expression by epithelial cells of the luminal lining of the digestive tract, thus establishing a mucosal barrier preventing contact of microbes and pathogens with the intestinal epithelium [12, 50]. Increasing the consumption of dietary fiber, thus increasing short-chain fatty acid production, and/or food containing dietary HDAC inhibitors could increase the expression of AMPs in the digestive tract. This in turn would increase the barrier protection in the gut lumen and reduce the rate or severity of intestinal infections. This is nicely demonstrated in the studies using a rabbit model of shigellosis [54, 56] and has shown some promise in a human trial [79].
The potential for VDR and FXR to bind to the VDRE in the human CAMP gene offers an abundance of new compounds that can be synthesized or obtained from the diet to produce potent ligands for these steroid hormone receptors and used to enhance AMP expression. For example, the therapeutic use of active vitamin D is hampered by the toxic side effects of hypercalcemia [12], and although synthetic analogs reduce these side effects, they still exist. On the other hand, analogs of LCA have been shown to lack this side effect, but activate VDR-target genes like CAMP [51].
The VDR may act as a receptor for additional nutritional ligands including curcumin and polyunsaturated fats including α-linolenic acid, docosahexaenoic acid, eicosapentaenoic acid and arachidonic acid [80]; however, we recently demonstrated that in tissue culture, only curcumin modestly induced CAMP gene expression through a yet uncharacterized VDR-independent mechanism (Guo et al. in press). Identification of additional nutritional compounds and their synthetic analogs would provide further options for increasing AMP gene expression for therapeutic uses.
AMPs are critical to the barrier defense provided by the innate immune system, and deficits in AMP production can increase susceptibility to infections. As discussed, numerous nutritional compounds and microbial by-products from metabolism of dietary factors have been shown to regulate the expression of AMPs. The possibility of improving the innate immune response or boosting barrier defenses toward infection by increasing the consumption of food items rich in these nutrients is an exciting prospect, but well-designed clinical and animal model studies need to be performed to demonstrate that compounds obtained from the diet can improve immune function by increasing AMP levels.
We thank members of the laboratory for critically reading this manuscript. This work was supported by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [5R01AI065604 to A.F.G.].
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
An opportunity for you to engage in Harley-Davidson's history, The HD Museum launched a new website Harley-Davidson Images where you can order a wide range of Art from the H-D Museum® Archives. Are offered several reprint options, allowing customers to find photos they want and have them printed on various media, including stretched canvas, wooden signs, archival paper and more. The collection of images on the site includes professional photography and candid shots dating back to 1903. Makes a great gift or addition to your office, shop, etc. At Harley-Davidson Images.
848 Houston Avenue
Idaho Falls, ID 83402
Phone: 208-523-1464
Toll Free: 800-863-5297
Mon: CLOSED
Tue: 9:00AM - 6:00PM
Wed: 9:00AM - 6:00PM
Thu: 9:00AM - 6:00PM
Fri: 9:00AM - 6:00PM
Sat: 9:00AM - 6:00PM
Sun: CLOSED


text:
Prostatitis classification
July 1, 2011 by Prostate Dr.
Prostatitis is an inflammation of the prostate gland that occurs in men. Statistics indicate that the
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diagnosis of prostatitis is assigned at 8% of all urologist and 1% of all primary care physician visits in the United States. [Collins MM,
Stafford RS, O'Leary MP, Barry MJ (1998). "How common is prostatitis? A national survey of physician visits". J. Urol. 159 (4): 1224–8]
In 1999, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) chose a new classification system.
Prostatitis classification related articles:
- Lived with chronic non-bacterial prostatitis for 10 years. Found the solution. As of today, I don't have it anymore: I've lived with non-bacterial prostatitis from 14 to my present age of 25.[…]All results came back negative. To avoid non-bacterial prostatitis, take it easy on your PC muscles.
- Prostatitis: the Inflamed prostate: Prostatitis is the inflamation of the prostate gland, and can be either: *acute prostatitis *chronic prostatitis ochronic bacterial prostatitis ochronic nonbacterial prostatitis *prostatodynia (also called Chronic Pelvic Pain Syndrome- CPPS)
- Prostatitis statistics: Some estimated prostatitis to affect an estimated 30-50% of males. But European statistics show 5-10% of men of fertile age suffer from it, while…
- Preventive (Prophylactic) prostatitis treatment: The preventive treatment of acute prostatitis (acute prostate inflammation) consists in avoiding, in clearing some of the causes favoring the localization of the infection at prostatic level
- Acute prostatitis treatments: The treatment of acute prostatitis offers much better results if applied in early stages.


text:
This weekend, the Hoboken Historical Museum will celebrate this summer fruit at its ninth annual Heirloom Tomato-Tasting Festival.
This Sunday from 1 p.m. to 5 p.m., stop by the museum for free samples from Catalpa Ridge Farm and neighboring New Jersey farms. Among the tomatoes to try will be the popular Aunt Ruby's German green and Brandywine pink. Tomatoes and other fresh farm produce will be available for purchase in the breezeway near the museum entrance.
The museum, located at 1301 Hudson Street, is also calling for volunteers to help out with the event.
For more information or to volunteer, call (201) 656 - 2240 or send an e-mail to firstname.lastname@example.com.


text:
Government programs
One of your headlines reads Child poverty worsened in S.C. yet welfare is up, food stamps are up, and every other government giveaway program is up. Guess what? It isnt working. Until we force people to be responsible for themselves, it will not work.
Kosher deli
I would like to see a kosher deli in Aiken instead of shrimp and grits.
Tiny print
When the new phone book was delivered, they should have left a magnifying glass. The print is so tiny you cant read it.
There was another break-in in New Ellenton. These young boys need to be off the street and the police chief isnt doing anything. Its not right that theyre breaking into peoples houses.
Traffic hazard
The crape myrtles on Richland Avenue need to be cut back. You cannot see. They are beautiful, but a traffic hazard.
Road projects
City Council, County Council and the SCDOT need to get together and figure out an immediate fix to repave Pine Log Road. We need this before we need any of these other road projects.
Feral cats
Anyone know of an inexpensive service that will fix feral cats? There is an old woman on Old Friar that feeds dozens; they have babies, get sick and die. She claims its too expensive to have them fixed. I think its irresponsible not to.
Climate change
The people who are worried about global warming obviously dont believe in evolution. If they did, they would believe that life would adapt to the climate change.


text:
Bear Claw Casino
Carlyle, Saskatchewan, Canada
|(306) 577-4577
|White Bear First Nation
|Mailing address:
|White Bear First Nation PO Box 1210
Carlyle, Saskatchewan
|Visit Bear Claw Casino's home page here:
Bear Claw Casino Website
Bear Claw Casino Discussion Forum
Sun noon-midnight; Mon-Thu 10am-midnight; Fri-Sat 10am-2am
Gambling Details
- Type of gaming facility: Casino
- American Indian Casino? Yes
- Sportsbook available? No
- Racebook available? No
- Off track betting? No
- Number of slot machines; VP machines: 133
- Total table games: 5
- Casino square feet: 15000
- Casino games not mentioned above: American Roulette, Blackjack, Let it Ride, Money Wheel, Multiple Action Blackjack
Top Online Casinos
Details of Bear Claw Casino's gambling facilities
Visit the following links to get back to the complete casino listings in Saskatchewan or Carlyle. Click here for more information on gambling in Saskatchewan, Carlyle's casinos. You can find World Casino Directory's article on Carlyle, Saskatchewan's casinos by visiting the links.
You can also find gambling in these other SK locations: Carlyle, Moose Jaw, North Battleford, Prince Albert and Regina. There are actually more gambling locations than listed here. You can visit the Saskatchewan gambling information page for a complete list of Casino cities.
© 2003-2016 E3WD Inc. All rights reserved. | Contact us


text:
Best route map between Milwaukee, WI and Kalamazoo, MI. This route take about 246 Miles.
The distance and estimated time is placed on the right depending on the status of the road.
, 10:13
, 11:13
* You can see Milwaukee, WI and Kalamazoo, MI photos above. We provide this photos from Google Panoramio service.
* Milwaukee, WI weather as celsius: °C
* Kalamazoo, MI weather as celsius: °C
* Weather information on route, provide by Open Weather Map.
All Rights Reserved. © 2010 - 2016 About Feedback


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The stock market appeared ready to end 2013 on a whimper rather than a bang, with Monday featuring mixed moves among the most popular market measures and relatively little volume. But that didn't keep certain stocks from posting sizable moves downward, with DryShips (NASDAQ: DRYS ) , Myriad Genetics (NASDAQ: MYGN ) , and Direxion Daily Gold Miners Bull 3x (NYSEMKT: NUGT ) among the worst performers in Monday's market.
DryShips fell more than 6%, giving back just a portion of the shipping giant's 27% gains last week. Several analysts over the weekend pointed to those gains as a golden opportunity to take profits, even as others believe that the worst for the shipping industry might finally have passed. With exposure to both dry-bulk and tanker shipping as well as its interest in its Ocean Rig (NASDAQ: ORIG ) deepwater drilling affiliate, DryShips offers attractive diversification for those looking to avoid a pure play on any one of those subsectors in shipping.
Myriad Genetics dropped 14% after investors panicked about possible reductions in reimbursement rates from the Centers for Medicare and Medicaid Services for its genetic tests. The proposed reimbursement rate from CMMS would lop nearly 50% off the current figure that Myriad receives for its test. Even though some investors argued that prospective cuts were already anticipated and that Medicare represents a relatively small part of Myriad's business, shareholders didn't hesitate to dump their shares. Myriad will now have to hope for the same sort of reimbursement reversal that has happened in previous years to other companies that rely on Medicare.
The Direxion Daily Gold Miners Bull 3x dropped 8%, as the triple-leveraged ETF followed gold-mining stocks downward in a late-afternoon drop as gold prices fell below the $1,200 mark. With many predicting that the price of gold in 2014 could remain weak, miners continue to find themselves under fire as cash flow becomes an increasing concern. Even major miner Goldcorp (NYSE: GG ) fell more than 3% today, and prospects for smaller miners are looking even grimmer in many cases.
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3741 NW 39th
Oklahoma City, OK 73122
Jimmy's Egg in Oklahoma City is the go-to place to score all your favorite breakfast foods. Whether you're looking for a ... read more...
8121 N Classen Blvd
Oklahoma City, OK 73114
This restaurant's name might be Soup Soup, but that's not all you'll find at this comfortable Oklahoma City location. ... read more...
6447 Avondale Dr
Oklahoma City, OK 73116
Come out to POPS Arcadia's sister location in Nichols Hills Plaza where you'll find the same ultra-modern design ... read more...
American, Sweet Treats
409 N Walker Ave
Oklahoma City, OK 73102
La Cueva Grill in downtown Oklahoma City offers a variety of Mexican and American foods to satisfy any appetite. ... read more...
American, Mexican
12215 N Pennsylvania Ave
Oklahoma City, OK 73120
Ajanta Cuisine of India, located in Oklahoma City, serves authentic Indian cuisine. Offering vegetarian dishes, ... read more...
Other International
5830 N Classen Blvd
Oklahoma City, OK 73118
Republic Gastropub, located in the growing Classen Curve district of Oklahoma City, is a modern interpretation of a ... read more...
Bar & Grill, American
1755 NW 16th St
Oklahoma City, OK 73106
Enjoy top notch coffee and fresh deli items at District House. This charming Plaza District eatery features a full ... read more...
Coffee Shop, Deli
1903 N Classen Blvd
Oklahoma City, OK 73106
Walk in to OKC's Café Antigua and instantly become transported to a neighborhood café nestled high ... read more...
Other International
2106 SW 44th St
Oklahoma City, OK 73119
Located in Oklahoma City, Naylamp Peruvian Restaurant offers a taste of authentic Peruvian cuisine. On the menu ... read more...
Other International
6901 S May Ave
Oklahoma City, OK 73159
Abel's Mexican Restaurant in Oklahoma City specializes in traditional Mexican food. Stop in for lunch or dinner ... read more...
Braum's Ice Cream & Dairy Store
620 NW 12th St
Moore, OK 73160
Braum's Ice Cream & Dairy Store in Moore is really three stores in one: an old fashioned soda fountain, grill and ... read more...
American, Sweet Treats
2925 W Britton Rd
Oklahoma City, OK 73120
Kim Wah Chinese Restaurant in Oklahoma City features a full service menu and lunchtime Chinese buffet. Local favorites ... read more...
2321 SW 74th St
Oklahoma City, OK 73159
Olive Garden in Oklahoma City serves a number of delicious Italian specialties inspired by the Tuscany region of Italy. ... read more...
303 E Sheridan Ave
Oklahoma City, OK 73104
Located in Bricktown near downtown Oklahoma City, Crabtown is the place to go for fresh seafood and Cajun ... read more...
2218 NW 23rd St
Oklahoma City, OK 73107
Moon Thai offers a unique mix of Thai food and Japanese sushi rolls. This little gem has quickly become a big contender ... read more...
5800 S Pennsylvania
Oklahoma City, OK 73119
Empress Express in Oklahoma City features Chinese cuisine. Start off with an order of egg rolls, teriyaki chicken, ... read more...
12225 N Pennsylvania Ave
Oklahoma City, OK 73120
Wingstop in Oklahoma City offers a variety of delicious wings. Whether you prefer regular, boneless or even strips, they ... read more...
Nancy's 57th Street Lighthouse
5708 N May Ave
Oklahoma City, OK 73112
Visit Nancy's 57th Street Lighthouse in Oklahoma City for a meal with a delicious twist on classic American favorites. ... read more...
4315 N Western Ave
Oklahoma City, OK 73118
Musashi's Japanese Steakhouse turns the art of fine cuisine into performance art as you watch your chef prepare your ... read more...
Asian, Steakhouse, Fine Dining
6070 S Western Ave
Oklahoma City, OK 73139
Great Wall in Oklahoma City features a large selection of Chinese food. From chow mein to egg foo young, Great ... read more...
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text:
I laugh a lot. I play frequently. I work hard. And I rarely calm down when asked.
Don't let the name fool you! While they do have big, juicy, delicious burgers; they also have AMAZING & HUGE build your own salads. They have something for everyone!
I know it's today, but in the article you mention Sunday. Just thought I'd point that out if you'd like to make a correction (= I will be there and I can't wait! What an awesome neighborhood to live in. I'm super lucky!
Um...the reason this article seems so outdated and the list so terrible is because this article is 2 years old!! Check it out below! Almost the exact same article was printed this time 2 years ago! Come on CP!! I used to love your independent spirit and your underdog mentality, but since you've gotten bigger, you've been making some poor choices (ie: firing the music editor, ignoring local foundation's attempts to have their event published online, etc...ridiculous). Oh and no, Charleston is NOT overrun with Clemson fans. I am one and I would know. I take shit for it all the time. Still love my Tigers. Does anyone know any bars in JI or WA to find like-minded Tiger fans? =)
Um...City Paper...think you might want to take down the previous post for it's vulgar language and offensive implications. That's just tacky. You must be a 15 yr old boy. Ugh.
Oh and btw: the cop wasn't fired for writing Dabo a ticket. He was fired for bragging about it online. WHAT an idiot.
Good God. While I don't agree with him comparing Spurrier to Paterno, I still feel that Spurrier went too far by calling for Morris's resignation. Now I realize I am one of very few Clemson fans in Charleston, but you don't see me boycotting organizations for showing their allegiance to Carolina or for saying unflattering remarks about Dabo or Clemson. I hear it every day. If you have an opinion, state it. The City Paper is known for printing controversial articles. They take risks. This may not have been a smart one due to the vast majority of Carolina fans in Charleston. But don't punish the paper for publishing an article that offended you. Just state your opinion back. That's what the comment section is for.
Yes, Derek. We are all keeping count. It's part of the rivalry. Just as relevant in the argument as the 3 losses in a row. Spurrier has put together an excellent team. No denying that. I just think he's an a@*hole because of the way he continuously flies off the handle and makes insensitive comments. Yes, Dabo lost it after the Carolina game. You will not find many instances of Dabo displaying this type of behavior. *Tweet that* Plus, Spurrier, who has much more clout than a Columbia reporter, called for this man's resignation because he's making a living and writing opinion pieces that are unpopular to Carolina fans. Really? Take a pouter. Spurrier is more adored in Columbia than some reporter. This poor man probably sh*t his pants when he heard Spurrier had threatened to quit if homeboy wasn't fired. Eesh. That's extreme. Brush it off, "OBC". Come on. I miss the days of fun teasing and good ole fashion rivalries. It's all gotten so ugly.


text:
Slow healing after knee arthroscopy
Q: Oc, i had a medial and lateral meniscus tear. had surgery jan 28 - 6 months ago. i still have knee pain in the joint line. i could bike and do some exercise but i still cant run , jump or make any sudden movements. im a little anxious. i play soccer, my teamate had the same injury however he is already back playing. my doc says its normal and recommended a cotizone shot. is this a good idea? or is this lingering joint line pain part of the healing process?
Usually the rehab post knee arthroscopic surgery, is about 4-6 weeks using crutches (depending if the ligaments were affected or not), non-bearing weight period. After these 6 weeks you will start progressively to bear weight on the affected knee, and range of motion exercises (flexion-extension), along with quads straightening, and hamstring stretches. It will be expected some inflammation and pain when you start the exercise routine, but you will control these with anti-inflammatory medication ("Aleve", "Motrin"). Not all the patients are the same and the healing process might take longer in some cases.
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text:
In a ruling likely to have implications in Pennsylvania and nationwide, a federal appeals court said Wednesday that states cannot bar same-sex couples from marrying.
In a 2-1 decision, the U.S. Court of Appeals for the 10th Circuit affirmed a lower-court ruling declaring Utah's ban on same-sex marriage unconstitutional.
The opinion came amid a flurry of legal activity on the issue Wednesday, including a ruling allowing gay marriage in Indiana, filings in a Pennsylvania appeal before the U.S. Court of Appeals for the Third Circuit, and changes to same-sex partner benefits in Allegheny County.


text:
Top Definition
To crave something or someone.
Feinin by K-Ci and JoJo...they loved that girl....or in another sense junkies fein junk. Aint no hate here.
by DeevaD August 13, 2005
Trending Now
Can you define these popular missing words?
A yearning for something.
I'm feinin' for your love.
by FoxY February 01, 2004
1.baby i just want you to know that i'm feinin you.
2.stop feining all ya haters.
2.stop feining all ya haters.
by aladdin April 19, 2005


text:
Photographer Garry Winogrand Captured America As It Split Wide Open
His indelible vision is the subject of a powerful retrospective at the Metropolitan Museum of Art.By Jerry Saltz
His indelible vision is the subject of a powerful retrospective at the Metropolitan Museum of Art.By Jerry Saltz
Titled "Death Becomes Her."By Véronique Hyland
A close friend of the designer shares never-before-seen sketches and tales of James's later years.
Two versions of this incredible, ineffable engraving.By Jerry Saltz
Not so fast, guys.By Justin Davidson
It comes down to one word.By Jerry Saltz
But details are still thin on the ground.By Véronique Hyland
Michelle Obama cut the ribbon at the Anna Wintour Costume Center's opening ceremony.By Véronique Hyland
"Tapestry Tom" is a newfound modernist.By Carl Swanson
"I hope this tide will float nearby boats and not swamp them."By Jerry Saltz
Singling out 44 particular pieces he loves.By Jerry Saltz
The museum has amended its lease with the city amid two lawsuits.By Joe Coscarelli
Why Balthus's The Guitar Lesson gives so many people the willies.By Jerry Saltz
"It's one of the greatest works of Western sculpture I've ever seen."By Jerry Saltz
The new installation presents us with a much more coherent, legible vision of one of the great achievements of world civilization.By Jerry Saltz
Isn't everyone reading the fine print?By Margaret Hartmann
People seem to think "recommended" admission prices are unclear.By Adam Martin
There's a shallow, pandering fecklessness to this pseudo-extravaganza.By Jerry Saltz
"This spells Starbucks: a place to hang out all day and have coffee."By Hugh Merwin
Yes, Anna Wintour is wearing a gold lobster on her skirt! Plus Carey Mulligan! Beyoncé! Gwyneth! More!By Charlotte Cowles


text: Review Content happy as always this is a great little gadget to have on the golf course. many uses Really good Great for golf bag! Bad packaging, see examples below The product itself is as advertised. However,the box containing the Swiss Army Golf Tool was mailed in a padded envelope and was badly crushed in transit, and no "directions" of any kind were included to indicate that it was, indeed, a golf tool and not a traditional Swiss Army Knife. My response was to cut out the description from the catalog and apply it to the least-damaged side of the box; then cover it up with transparent tape. The resulting mess gives no indication that Sharper Image was involved in any way, for which you should be grateful.