text:
A Phase III Study of Dasatinib vs. Imatinib in Patients With Newly Diagnosed Chronic Phase CML (DASISION)
This study has been completed.
Bristol-Myers Squibb
Information provided by (Responsible Party):
Bristol-Myers Squibb
ClinicalTrials.gov Identifier:
First received: May 30, 2007
Last updated: September 25, 2014
Last verified: September 2014
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The purpose of this clinical research study is to compare the rate of confirmed complete cytogenetic response (cCCyR) of dasatinib to imatinib therapy within 12 months after randomization in newly diagnosed chronic phase Philadelphia positive chronic myeloid leukemia (Ph+ CML) patients. The safety of this treatment will also be studied.
Myeloid Leukemia, Chronic
Drug: Dasatinib
Drug: Imatinib
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|An Open-Label, Randomized, Multicenter Phase III Trial of Dasatinib (SPRYCEL®) vs. Standard Dose Imatinib (400 mg) in the Treatment of Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive Chronic Myeloid Leukemia
Resource links provided by NLM:
MedlinePlus related topics: Chronic Myeloid Leukemia Leukemia
Drug Information available for: Imatinib Imatinib mesylate Dasatinib
Genetic and Rare Diseases Information Center resources: Myeloid Leukemia Chronic Myeloid Leukemia Chronic Myeloproliferative DisordersU.S. FDA Resources
Further study details as provided by Bristol-Myers Squibb:
Primary Outcome Measures:
- Number of Participants With Best Confirmed Complete Cytogenetic Response (cCCyR) Within 12 Months [ Time Frame: Pre-treatment, every 3 months up to 12 months ] [ Designated as safety issue: No ]Cytogenetic response (CyR) is based on the prevalence of Philadelphia positive (Ph+) cells in metaphase from Bone Marrow (BM) sample. (Ideally, 25 metaphases but at least 20 metaphases from a BM sample were evaluated). Complete Cytogenetic Response (CCyR)=0% Ph+ cells in metaphase in BM. A confirmed cytogenetic response (cCCyR)=those in which all measurements up to at least 28 days after the initial response show an equivalent or better complete cytogenetic response.
Secondary Outcome Measures:
- Time-in Confirmed cCCyR at Any Time [ Time Frame: Every 3 months for 2 years, then once per year for 3 years and/ or once per year for subjects in confirmed complete cytogenetic response at any timepoint or investigator's decision ] [ Designated as safety issue: No ]Time-in cCCyR at any time was computed for all randomized subjects. For subjects with cCCyR at any time, it is measured from the time measurement criteria are first met for CCyR(provided it is confirmed later) until the date of progression or death. Subjects with cCCyR who neither progress nor die are censored on the date of their last cytogenetic assessment. Subjects without cCCyR are considered to have progressed on day 1.
- Number of Participants With Major Molecular Response (MMR) at Any Time [ Time Frame: Pre-treatment, every 3 months for 2 years, then every 6 months for 3 years ] [ Designated as safety issue: No ]Molecular response was assessed using BCR-ABL transcript levels measured by realtime quantitative polymerase chain reaction (RQ-PCR). A major molecular response (MMR) is defined as a ratio BCR-ABL/ABL ≤0.1% on the international scale (i.e., at least 3 log reduction from a standardized baseline value).
- Time to Confirmed CCyR Overall [ Time Frame: Every 3 months for 2 years, then once per year for 3 years and/ or once per year for subjects in confirmed complete cytogenetic response at any timepoint ] [ Designated as safety issue: No ]
The Time-to cCCyR for participants with cCCyR is defined as the time from the randomization date until criteria are first met for CCyR (provided it is confirmed later). The time-to cCCyR for all randomized subjects censors non-responders who do not progress at their cytogenetic assessments and non-responders who progress at the maximum time of all randomized subjects.
- Time to MMR Overall [ Time Frame: Every 3 months for 2 years, then every 6 months for 3 years ] [ Designated as safety issue: No ]The Time-to MMR for participants with MMR is defined as the time from randomization date until measurement criteria are first met for MMR. The time-to MMR for all randomized subjects censor non-responders who do not progress at their last molecular assessments and non-responders who progress at the maximum time of all randomized subjects.
- Percentage of Participants With Progression-free Survival (PFS) at 12 Months [ Time Frame: Participants were followed for at least 5 years ] [ Designated as safety issue: No ]PFS=time from randomization until progression (any progression/death within 30 days of last dosing date, or between 30-60 days of last dosing prior to start of secondary therapy). Those who did not progress/die or who progressed/died after 60 days of last dose were censored at last on-study hematologic/cytogenetic assessment; those with progression/death 30-60 days of last dosing date & after start date of secondary therapy censored at last on-study hematologic/cytogenetic assessment prior to start of secondary therapy; those who had not received study treatment censored on date randomized.
- Percentage of Participants With Overall Survival (OS) at 12 Months [ Time Frame: Participants were followed for at least 5 years ] [ Designated as safety issue: No ]Overall survival (OS) was defined as the time from randomization to the date of death. If the participant had not died, survival was censored on last date the participant was known to be alive.
Other Outcome Measures:
- Number of Participants With Adverse Events (AEs), Drug-related AEs, Drug-related Grade 3/4 AEs, Drug-related Fluid Retention AEs (FRAEs), Drug-related Serious Adverse Events(SAEs), Drug-related AEs Leading to Discontinuation, and All Deaths [ Time Frame: Participants were followed for at least 5 years ] [ Designated as safety issue: Yes ]Grade 3=Severe, Grade 4=Life-threatening or disabling. AE=any new untoward medical occurrence or worsening of a pre-existing medical condition in a subject administered an investigational (medicinal) product and that does not necessarily have a causal relationship with this treatment. SAE=any untoward medical occurrence that at any dose results in death, is life-threatening, requires inpatient hospitalization or causes prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, or is an important medical event.
- Number of Participants With Grade 3/4 On Study Laboratory Abnormalities [ Time Frame: Participants were followed for at least 5 years ] [ Designated as safety issue: Yes ]Grade 3= Severe AE; Grade 4=Life-threatening or disabling AE. Absolute neutrophil: grade 3 < 1000-500/mm^3; grade 4 < 500/mm^3. Hemoglobin: grade 3 < 8.0-6.5 g/dL; grade 4 < 6.5 g/dL. Platelets: grade 3 < 50,000-25,000/mm^3; grade 4 < 25,000/mm^3. Alanine Aminotransferase (ALT)/Aspartate Aminotransferase (AST): grade 3 >5.0-20 x ULN (upper limit of normal), grade 4 > 20 x ULN. Total Bilirubin: grade 3 > 3-10 x ULN; grade 4 > 10x ULN. Sample normal ranges (may vary by institution): ALT, Female: 7-30 U/L, Male: 10-55 U/L; AST, Female: 9-25 U/L, Male10-40 U/L; Total Bilirubin: total 0.0-1.0 mg/dL
|Study Start Date:
|August 2007
|Study Completion Date:
|December 2013
|Primary Completion Date:
|December 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: A
Drug: Dasatinib
Tablets, oral, dasatinib 50-140 mg once daily (QD)
Other Names:
|Active Comparator: B
Drug: Imatinib
Tablets, oral, imatinib 200-800 mg, QD
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com
Inclusion Criteria:
- Male & Female ≥18 years
- Chronic Phase Ph+ CML
- Eastern Cooperative Oncology Group Performance Status (ECOG PS) score 0-2
Exclusion Criteria:
- Pleural Effusion
- Uncontrolled cardiovascular (CV) disease
- Significant bleeding disorder unrelated to CML
- Prior treatment with interferon/imatinib/dasatinib/anti-CML systemic treatments except anagrelide/hydroxyurea
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00481247
Show 109 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00481247
Show 109 Study Locations
Sponsors and Collaborators
Bristol-Myers Squibb
|Study Director:
|Bristol-Myers Squibb
|Bristol-Myers Squibb
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Bristol-Myers Squibb:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 28, 2016
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Hughes TP, Saglio G, Quintás-Cardama A, Mauro MJ, Kim DW, Lipton JH, Bradley-Garelik MB, Ukropec J, Hochhaus A. BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase. Leukemia. 2015 Sep;29(9):1832-8. doi: 10.1038/leu.2015.168. Epub 2015 Jun 29.
Fujisawa S, Nakamae H, Ogura M, Ishizawa K, Taniwaki M, Utsunomiya A, Matsue K, Takamatsu Y, Usuki K, Tanimoto M, Ishida Y, Akiyama H, Onishi S. Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up. Int J Hematol. 2014 Feb;99(2):141-53. doi: 10.1007/s12185-013-1470-1. Epub 2013 Dec 20.
Jabbour E, Kantarjian HM, Saglio G, Steegmann JL, Shah NP, Boqué C, Chuah C, Pavlovsky C, Mayer J, Cortes J, Baccarani M, Kim DW, Bradley-Garelik MB, Mohamed H, Wildgust M, Hochhaus A. Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION). Blood. 2014 Jan 23;123(4):494-500. doi: 10.1182/blood-2013-06-511592. Epub 2013 Dec 5.
Kantarjian HM, Shah NP, Cortes JE, Baccarani M, Agarwal MB, Undurraga MS, Wang J, Ipiña JJ, Kim DW, Ogura M, Pavlovsky C, Junghanss C, Milone JH, Nicolini FE, Robak T, Van Droogenbroeck J, Vellenga E, Bradley-Garelik MB, Zhu C, Hochhaus A. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION). Blood. 2012 Feb 2;119(5):1123-9. doi: 10.1182/blood-2011-08-376087. Epub 2011 Dec 9.
Kantarjian H, Shah NP, Hochhaus A, Cortes J, Shah S, Ayala M, Moiraghi B, Shen Z, Mayer J, Pasquini R, Nakamae H, Huguet F, Boqué C, Chuah C, Bleickardt E, Bradley-Garelik MB, Zhu C, Szatrowski T, Shapiro D, Baccarani M. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2010 Jun 17;362(24):2260-70. doi: 10.1056/NEJMoa1002315. Epub 2010 Jun 5.
|Responsible Party:
|Bristol-Myers Squibb
|ClinicalTrials.gov Identifier:
|NCT00481247 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 30, 2007
|Results First Received:
|November 23, 2010
|Last Updated:
|September 25, 2014
|Health Authority:
|Australia: Department of Health and Ageing Therapeutic Goods Administration
India: Central Drugs Standard Control Organization
Greece: National Organization of Medicines
Singapore: Clinical Trials & Epidemiology Research Unit (CTERU)
Japan: Pharmaceuticals and Medical Devices Agency
Turkey: Ministry of Health
China: Food and Drug Administration
South Korea: Korea Food and Drug Administration (KFDA)
Czech Republic: State Institute for Drug Control
Hungary: National Institute of Pharmacy
Poland: National Institute of Medicines
Russia: Ministry of Health of the Russian Federation
Austria: Federal Office for Safety in Health Care
Germany: Federal Institute for Drugs and Medical Devices
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Spain: Spanish Agency of Medicines
Argentina: Administracion Nacional de Medicamentos, Alimentos y Tecnologia Medica
Brazil: National Health Surveillance Agency
Chile: CONEP
Colombia: INVIMA Instituto Nacional de Vigilancia de Medicamentos y Alimentos
Peru: Instituto Nacional de Salud
Mexico: Federal Commission for Sanitary Risks Protection
Denmark: Danish Dataprotection Agency
Italy: Ministry of Health
Belgium: The Federal Public Service (FPS) Health, Food Chain Safety and Environment
Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Keywords provided by Bristol-Myers Squibb:
Chronic Phase Philadelphia Chromosome Positive Chronic Myeloid Leukemia
Additional relevant MeSH terms:
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Neoplasms by Histologic Type
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Translocation, Genetic
Chromosome Aberrations
Pathologic Processes
Imatinib Mesylate
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 28, 2016


text:
I just wanted to update you ladies and ask for prayers during this difficult time. I started bleeding Saturday so I went in Sunday and my numbers were still doubling but no gestational sac as seen at 5.1 weeks. Monday night I had severe pain and was still bleeding but I waited until Tuesday morning for my schedules u/s. Our suspision was confirmed...my bean had implanted in my tube--it was an ectopic pregnancy. We scheduled surgery for yesterday afternoon. turns out my tube had ruptured and was removed We will try again when all heals.
Sad weekend (loss ment)
:bigarmhug: I am dearly sad for your loss and am sending prayers and healing thoughts your way
I am so very sorry for your loss. :bigarmhug: You are in my thoughts and prayers.
Oh no I am so sorry to hear of your loss, I had the same thing happen to me last April but no bleeding my surgery was 4/30 and I lost my right tube.
I know how miserable the pain is after the surgery and I am sending you TONS and TONS of healing vibes!!
You are in my prayers and I wish you all the best on your next BFP. I had my surgery the end of April and got prego in Oct so I will be rooting for you
I'm so sorry for your loss. :bigarmhug: Please take care of yourself and feel free to PM me if you want to vent.
I'm so sorry.. I've actually been wondering how you are. Take care of yourself.
I am so sorry to hear this! :bigarmhug: you are certainly in my prayers.
Oh Mary Anna, I am so so sorry. My thoughts and prayers are with you. Please know that I am a pm away if you need to talk/vent/cry. :bigarmhug::bigarmhug::bigarmhug::bigarmhug:
Hey Mary,
I am so saddened to hear of your loss. I know how hard it is and I don't wish it upon my worst enemy! You will be in my thoughts and prayers. Please keep us posted in regards to your recovery.
Again, I am so very sorry!

subset: commoncrawl


text:
Fixed PriceBudget: $1,000
Start DateNovember 20, 2012
General App Idea and Requirements:
We are looking to have an app developed for the iPhone and iPad.
The main page of the app will have drop down menus to the right, and a map of a city on the left. Once a user chooses the drop down variables, locations and prices are shown on the (Apple?) map to the left, so that the user can do a quick price comparison on specific service locations. The user should then be able to click on a specific location and open up a text box to see more information on the business, including a link to get directions through 'Maps'.
Note: We will require a CMS portion, where we can update the database ourselves on details such as, prices, locations, thumbnail pictures etc.
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• You must have extensive experience creating apps for the iPhone/iPad which have already been accepted by Apple onto iTunes
When you place a bid, please provide a portfolio of your previous work which can be found on iTunes.
The following app is a good example of what quality we and functionality we're looking for: Zillow
Timeline: Upon acceptance, we would like this project completed within 3-4 weeks.
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This should be an easy and quick project for an experienced Developer!
Skills: ipad
About the Client
Verdun 09:46 PM
Jobs Posted
50% Hire Rate, 1 Open Job
Total Spent
1 Hire, 0 Active


text:
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In this lively and enlightening study, Kathleen B. Casey explores the ways in which the gender- and race-bending spectacles of vaudeville dramatized the economic, technological, social, and cultural upheaval that gripped the United States in the early 20th century. She focuses on four key performers: Eva Tanguay, Julian Eltinge, Lillyn Brown, and Sophie Tucker.
"Both book and narrator are first rate!"
Advanced tips & strategy guide. This is the most comprehensive and only detailed guide you will find online. With the success of my hundreds of other written guides and strategies I have written another advanced professional guide for new and veteran players. This gives specific strategies and tips on how to progress in the game, beat your opponents, acquire more coins and currency, plus much more!
Take a peek inside the heads of some of the world's greatest living graphic designers. How do they think, how do they connect to others, what special skills do they have? In honest and revealing interviews, 19 designers, including Stefan Sagmeister, Michael Beirut, David Carson, and Milton Glaser, share their approaches, processes, opinions, and thoughts about their work with noted brand designer Debbie Millman. The internet radio talk host of Design Matters, Millman persuades the greatest graphic designers of our time to speak frankly and openly about their work.
"Not what I expected but"
From one of the most acclaimed and profound writers in the world of comics comes a thrilling and provocative exploration of humankind's great modern myth: the superhero. In this exhilarating work of a lifetime, Grant Morrison draws on art, science, mythology, and his own astonishing journeys through this shadow universe to provide the first true history of the superhero - why they matter, why they will always be with us, and what they tell us about who we are... and what we may yet become.
"Geek Gospel"
The rhythm, ritual, and pleasure of knitting are celebrated in this new collection for lovers of both knitting and literature. In Knitting Pearls, two dozen writers write about the transformative and healing powers of knitting. Lily King remembers the year her family lived in Italy, and a knitted hat that helped her daughter adjust to her new home. Laura Lippman explores how converting to Judaism changed not only Christmas but also her mother's gift of a knitted stocking.
From young artists trying to elbow their way in to those working hard at dropping out, White's essential audiobook offers a once-in-a-generation glimpse of the inner workings of the American art world at a moment of unparalleled ambition, uncertainty, and creative exuberance.
"Mispronunciations Spoil This Reading!"
Inside the Business of Graphic Design casts a precise and realistic light on the risks, requirements, and rewards of running a creative and successful design business. Whether you dream of setting up a small studio, or whether you've been on your own for years, this provocative guide is an important source of success strategies for every graphics professional.
"Broad overview of 60 companies"
Toward the end of his long life, Tiziano Vecelli - known to the world ever since as Titian (circa 1488-1576) - was at work on a number of paintings that he kept in his studio, never quite completing them, as though wanting to endlessly postpone the moment of closure. Produced with his fingers as much as with the brush, Titian's last paintings are imbued with a unique rawness and immediacy without precedent in the history of Western art.
"A trip to Venice"
The Art Instinct combines two of the most fascinating and contentious disciplines, art and evolutionary science, in a provocative new work that will revolutionize the way art itself is perceived. Aesthetic taste, argues Denis Dutton, is an evolutionary trait, and is shaped by natural selection. It's not, as almost all contemporary art criticism and academic theory would have it, "socially constructed".
"A breath of fresh air!"
John Heskett wants to transform the way we think about design by showing how integral it is to our daily lives, from the spoon we use to eat our breakfast cereal, and the car we drive to work in, to the medical equipment used to save lives. Design combines 'need' and 'desire' in the form of a practical object that can also reflect the user's identity and aspirations through its form and decoration. This concise guide also looks at how different cultures and individuals personalize objects.
By the director of the hit documentary Behind the Burly Q, comes the first-ever oral history of American burlesque - as told by the performers who lived it, often speaking out here for the first time. By telling the intimate and surprising stories from its golden age through the women (and men!) who lived it, Behind the Burly Q reveals the true story of burlesque, even as it experiences a new renaissance.
"amazing story of an amazing art form"
Diane Arbus was one of the most brilliant and revered photographers in the history of American art. Her portraits, in stark black and white, seemed to reveal the psychological truths of their subjects. But after she committed suicide at the age of 48, the presumed chaos and darkness of her own inner life became, for many viewers, inextricable from her work. In the spirit of Janet Malcolm's classic examination of Sylvia Plath, The Silent Woman, William Todd Schultz's An Emergency in Slow Motion reveals the creative and personal struggles of Diane Arbus.
"The Title Says It All"
Contemporary art has never been so popular - but what is 'contemporary' about contemporary art? What is its role today, and who is controlling its future? Julian Stallabrass takes us inside the international art world to answer these and other controversial questions, and to argue that behind contemporary art's variety and apparent unpredictability lies a grim uniformity. Its mysteries are all too easily explained, its depths much shallower than they seem.
"Marxist critique of the power elites not much art."
Art today is defined by its relationship to money as never before. Prices of living artists' works have been driven to unprecedented heights, conventional boundaries within the art world have collapsed, and artists now think ever more strategically about how to advance their careers. Artists no longer simply make art, but package, sell, and brand it. Noah Horowitz exposes the inner workings of the contemporary art market, explaining how this unique economy came to be, how it works, and where it's headed.
An introduction to philosophy through film, Thinking Through Film: Doing Philosophy, Watching Movies combines the exploration of fundamental philosophical issues with the experience of viewing films, and provides an engaging reading experience for undergraduate students, philosophy enthusiasts and film buffs alike. An in-depth yet accessible introduction to the philosophical issues raised by films, film spectatorship and film-making.
"The racing narration is an impediment."
The next best thing to having a room key to the Chelsea Hotel during each of its famous - and infamous - decades The Chelsea Hotel, since its founding by a visionary French architect in 1884, has been an icon of American invention: a cultural dynamo and haven for the counterculture, all in one astonishing building. Sherill Tippins, author of the acclaimed February House, delivers a masterful and endlessly entertaining history of the Chelsea and of the successive generations of artists who have cohabited and created there.
"dope and hostess cupcakes"
Thanks to Salem sea captains, Gilded Age millionaires, curators on horseback, and missionaries gone native, North American museums now possess the greatest collections of Chinese art outside of East Asia itself. How did it happen? The China Collectors is the first full account of a century-long treasure hunt in China from the Opium Wars and the Boxer Rebellion to Mao Zedong's 1949 ascent.
The drip paintings of Jackson Pollock, trailblazing Abstract Expressionist, appear to be the polar opposite of Thomas Hart Benton's highly figurative Americana. Yet the two men had a close and highly charged relationship dating from Pollock's days as a student under Benton. Pollock's first and only formal training came from Benton, and the older man soon became a surrogate father to Pollock.
"Not Worth the Read"
Salvador Dalí, Jerome Robbins, Jackie Onassis. Gregory Peck, Mick Jagger, S. J. Perelman, I. M. Pei. Philip Johnson, Josephine Baker, John Lennon: They, and so many more who made New York City the center of the universe in the 1970s, all had one thing in common besides their adopted hometown - they shopped at a legendary palace of books, music, and art: Rizzoli Books at 712 Fifth Avenue. There, Kennedys and Rockefellers mingled with tourists and "regular" customers under the watchful gaze of sophisticated employees.
For more than half a century, Ada Louise Huxtable's keen eye and vivid writing have reinforced to readers how important architecture is and why it continues to be both controversial and fascinating - making her one of the best-known critics in the world. On Architecture collects the best of Huxtable's writing from the New York Times, New York Review of Books, Wall Street Journal, and her various books. In these selections, Huxtable examines the 20th century's most important architectural masters and projects.
"Embarassing narration"


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After Being Attacked in Milan, Gigi Hadid Wants Women Everywhere to Know They Have the Right to Defend Themselves
Last week, reporter Vitalii Sediuk, notorious for pulling bizarre, often violent, celebrity-baiting stunts, creeped out the world when he grabbed Gigi Hadid as she exited the Max Mara show during Milan Fashion Week.
Thanks to Gigi's superior boxing skills, the slight model successfully fought off Sediuk, who'd grabbed her and picked her up against her will. "Who the fuck are you, you piece of shit?" Hadid yelled, chasing after him as he ran off to escape her expertly aimed elbow jabs.
Gigi defended herself when a man grabs her after the Max Mara show. pic.twitter.com/IsHEkTkkER
— Hadid News (@HadidNews) September 22, 2016
As Lena Dunham wrote in today's Lenny Letter, the paparazzi footage of the event "is equal measures upsetting and empowering. It is chilling to watch, in real time, the ownership a stranger seems to feel toward a body he considers public domain. But it's also stirring: in one swift movement, without the aid of her bodyguards, Gigi makes it clear that she will not be made to feel like anyone's property." (more…)


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Featured Golf News
2016 PGA Championship Moved Up a Month
Normally a fixture in August, the fourth and final major of the year - the PGA Championship - will be shifted to July in 2016, making way for golf's re-introduction as a sport in the Rio Olympics.
The 98th PGA Championship at Baltusrol Golf Club in Springfield, N.J., will be held the week of July 25-31 as the PGA of America marks its centennial year by joining the golf world in preparing for the game's return to the Olympic Games.
The PGA Championship will be played in July for the first time since 1968. With the exception of 1971, it has been conducted in August every year, beginning in 1969.
Baltusrol, home of many memorable U.S. majors, was selected in 2008 as the site of the 98th PGA Championship. The Rio Summer Olympics, scheduled for August 5-21, will have men and women golf competitions for the first time since 1904 at the St. Louis Games. Entrants in 2016 will be determined by the Official World Golf Rankings as of July 11, 2016.
"The PGA of America is excited for what the year 2016 means for our association and the game of golf. It promises to be a historic season on many levels," said PGA of America president Ted Bishop. "We celebrate our centennial; our PGA Championship is being hosted on one of the greatest courses in America and the Olympic Games cap the summer by welcoming back golf as an official sport.
"We believe that moving up the PGA Championship date that year is a win-win for our viewing audience, our spectators as well as for what is likely to be, once again, the strongest field in golf."
The PGA Championship traditionally is the final event where American golfers can earn points in attempting to get an automatic berth in the biennial team event. It will still serve that purpose in advance of the Americans competing against Europe in the 41st Ryder Cup, September 27 through October 2, 2016, at Hazeltine National Golf Club in Chaska, Minn.
Baltusrol's Lower Course, where Phil Mickelson won the Wanamaker Trophy in 2005, is the second New Jersey course to host the championship, following Seaview Country Club in Atlantic City, where in 1942 Sam Snead earned the first of his three PGA titles.
Virtually every celebrated champion in American golf has competed at Baltusrol, from Willie Anderson, Francis Ouimet, Walter Hagen and Bobby Jones to Gene Sarazen, Ben Hogan, Arnold Palmer, Jack Nicklaus, Mickey Wright, Nancy Lopez, Tom Watson and Tiger Woods.
Here are the sites of future PGA Championships:
2014 Valhalla Golf Club, Louisville, Ky.
2015 Whistling Straits, Kohler, Wis.
2016 Baltusrol Golf Club, Springfield, N.J.
2017 Quail Hollow Club, Charlotte, N.C.
2018 Bellerive Country Club, St. Louis, Mo.
2019 Bethpage Black, Farmingdale, N.Y.
2020 TPC Harding Park, San Francisco, Calif.
2022 Trump National Golf Club, Bedminster, N.J.
For more information the PGA of America, visit www.pga.com.
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I got my first pair of Lily Padz the other day and I love them, but it seems when I take them off my boobs are hard and my nipples are itchy and they sting. It's nice to not have the stains on my clothing and to be able to wear nursing pads without a bra (I wore them to bed last night bralessĀand they didn't fall off!) but I'm starting to wonder if maybe they are kind of plugging my boobs up?
They don't obsorb or collect any liquid, so I'm wondering if maybe that is causing my boobs to freak out because the colostrum isn't able to come out when it wants to?
Does anyone know what I mean or understand what I'm talking about? If you have used these did the same thing happen to you?
Lily Padz question! (TMI kinda!)
I got my first pair of Lily Padz the other day and I love them, but it seems when I take them off my boobs are hard and my nipples are itchy and they sting. It's nice to not have the stains on my clothing and to be able to wear nursing pads without a bra (I wore them to bed last night bralessĀand they didn't fall off!) but I'm starting to wonder if maybe they are kind of plugging my boobs up?
my breasts are super sensitive and hard. I do not wear pads at all right now. I think it is just a pregnancy thing?? I dont remember hurting this bad in my other 2 pregnancies, but I have been super sore almost this whole pregnancy, I did nurse until 3 months ago, but the pain started back again a few weeks ago.
I do have over supply and over active let down issues, and these helped a ton, I was sick of wearing pads non stop, never had an issue, other than sometimes I would have so much pressure I would leak into them, dont think I ever spilled out until I took them off, I did nurse a ton.
But anyways, maybe the itching is a rash from possibly over heating at night and it preventing air flow?? When I wore them they were taken off every 1-2 hours for nursing, so I had some time for my breasts to breath
I"m not sure on the plugging things up side, but I was so frustrated with bras that i could've just shot someone a couple of weeks ago. ┬ĀI can't find the right size and they're super uncomfy... So i went to kohl's and found that St. Eve has a sports like bra without straps that stays up well and will hold nursing pads/absorb some on their own. ┬ĀHere's the link, just as something else to try (I usually forget that i have them on, or at least feel the same way as wearing a camisole with the built in bra)... ┬Āhttp://www.kohls.com/kohlsStore/intimates/bras/wirefreebras/PRD~778923/St+Eve+Bandeau+Bra.jsp
They also had some pretty awesome colors when i went into the store so they're not just comfy, but fun too!
Michael Christopher 10/4/08 and Jack Andrew 9/14/11 and little Angel 9/12/13
My experience with Lily padZ was that my let down reflex with milk (not colostrum) was sooooo strong it would pop the lily padz off within a hald hour, cauing my shirt to get ruined. I wound up using them for 2 days and they just didn't work for my powerful milk! I go through about 20-30 disposables a day.
Jamie - Me, the Husband, and Our 3 Kids:
My 15 Year Old Daughter
+ February 2010 Girl
+ September 2011 Boy - WaterBirth HypnoBaby!
My boobs have never really gotten hard this whole pregnancy, or maybe they have and I just wasn't paying attention until now. My boobs leak sooo bad though. I just stopped nursing right before I got pregnant, so it has been awhile but not too long. For most of the pregnancy I've just been wearing a bra and┬Ā Lansinoh pads but the cost is adding up very quickly so I thought maybe this would be the best way to go. I haven't hardly taken the Lily Padz off except to wash them and shower, so they've basically constantly been on for a few days.
I'm going to check out the bra. :) I'm thinking about getting some of the washable NUK nursing pads too.
Jamie - If I don't wear a bra or the LPz my boobs leak everywhere. I tried sleeping one night with just a shirt on and woke up with my sheets soaked.
Have you thought of cloth nursing pads? Saved me a ton. I was also going through a ton of disposables. I would over load a pair if I went more than an hour in them sometimes. I wore them until I was 8-9 months into nursing.
I have about 6 pairs now, I plan on making or buying more to save money, since 6 pairs will not get me through a day.
ETA I also have had days with DS and DD where I would soak my shirt at night when pregnant. the pressure from sleeping on my side would make me leak. Sometimes I leak in the day but it is usually only a few drops.
A married to A = A+A+A+babyA on the way!!Ā
due Sept 16 2011
I couldn't get the Lily Padz to work for me last time; I have very large boobs, though (they were a G-H by the time I had DS).┬Ā When I put them on, they didn't fit right; my boobs looked funny-shaped, even through a bra & shirt.┬Ā I really liked the cloth nursing pads I had once my boobs weren't leaking too badly (after the first several months), but in the beginning, I basically had to use the disposeable ones 'cause I leaked so much.┬Ā I tried Avent and Lansinoh, and liked the Lansinoh ones way better.
SAHM to G - 09/15/2009, K - 09/13/2011, R - 09/26/2013, and TBD - EDD 6/1/2016
I think when my mother in law comes over on Tuesday I'm going to try and make some reuseable ones. I've been looking stuff up on how to do it and it doesn't seem too hard.
Also, I googled a bunch of stuff and have found that a lot of women who use Lily Padz a lot get a yeast infection on their nipples? No thanks!
Sometimes when my milk let down strong, the pads would fill then pop. But most of the time they worked as expected.
I'm happy to say, my fish taco is still stuffable
Learn more
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text: The Seine runs through the heart of Paris, dividing it into the Left and Right Bank, providing undisturbed views of the city's iconic attractions including the Eiffel Tower, Notre Dame and the Louvre. A Seine Cruise allows you to enjoy all these sites and the gorgeous architecture of the many bridges. A Seine cruise is a must-do activity and Local Paris Tours offers a variety of tours suitable for every traveller's needs. Book a Seine cruise today at guaranteed low prices!


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Charlie Sheen Demands 50% Raise, To $3 Million / Episode (Video)
The media gift that is Charlie Sheen keeps on giving. On NBC's Today Show this morning he demanded a 50% raise to $3 million per episode to return to Two And A Half Men.
I'm sure we haven't heard the last of this…
Visit msnbc.com for breaking news, world news, and news about the economy


text: General Council General Council Welcomes Andy Samuels at October Meeting Posted On: October 16, 2015 The General Council met October 9-11, 2015 at the SDB Center in Janesville, WI. It was a privilege to welcome Andy Samuels as the newest member, elected for a five year term at 2015 General Conference in Lancaster, PA last July. The other members of ... Read More Tags: General Council Category: General Council | Comment


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We dined after the show. We saw other people bring food and drink into the show.star this tip starred
The weather was Sunny with a little breeze.. I wore Capri pants, boots, and two blouses..star this tip starred
theatre very hot. Chairs that should be banned by U.N. for cruelty.star this tip starred
Seats are cruel.star this tip starred
Parking was easy at the theater. Lots of restaurants a block and half away on 18th.
PlayGround Film Festivalstar this tip starred
Just $4 for a generous pour of wine. Nice.star this tip starred
Usually foggy in that part of town, so layer your clothingstar this tip starred
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DirecTV - Going from Choice Xtra to Select Package?
I currently have the grandfathered choice xtra classic package, with 3 HD dvrs that are all connected for around 89.00 dollars. I was thinking of moving over to the select package which would drop our bill down to 55 dollars. I just wanted to see if you guys thought this would be a good move. I know typically it's not a good idea to loose grandfathered plans, but I don't watch any sports channels which seems to be the major difference between the choice xtra classic package and the select package.
Just wanted to get some thoughts before I pulled the trigger.
Just wanted to get some thoughts before I pulled the trigger.
post #2 of 2 Old 07-23-2014, 12:21 PM
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Try asking in the DirecTV master thread in the HDTV Programming section. All of the D* experts hang out there and you'll get a faster response. This area is for technical discussions. Thanks.
Walking the fine line between jaw-dropping and a plain ol' yawn.
Last edited by DrDon; 07-23-2014 at 12:32 PM.
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Refrigerator Stolen From Palm Springs HomePolice have arrested three people and are searching for a fourth man suspected of stealing a refrigerator, among other items, from a Palm Springs home.
Palm Springs Couple Allegedly Dined, Dashed In Front Of Detectives Having BreakfastPolice say a couple who attempted to dine-and-dash from a popular breakfast joint did it in front of several Palm Springs Police Department detectives.
Burglary Reported At Former Palm Springs Home Of Marilyn MonroePolice were called out to Marilyn Monroe's former Palm Springs home on the report of a burglary Wednesday.
Homeowner Sued For $25 Million Over California WildfireThe lawsuit says that a short in a poorly maintained electrical junction box sparked a blaze in the San Jacinto Mountains above Palm Springs that charred more than 27,500 acres of brush and timber.
Suspicious Package Closes Road Near Palm Springs AirportA suspicious package was found neat the Palm Springs International Airport, causing the closure of a nearby road
Palm Springs Man, 44, Accused Of Physically, Sexually Assaulting Couple After Breaking Into Their HomeOn Thursday, they identified the suspect as Thomas Mabe of Palm Springs.
Palm Springs Home That Appeared In James Bond Film Goes On SaleA Southern California landmark located in Palm Springs is up for sale.
Horse Airlifted To Safety After Falling Into Ravine Near Palm SpringsSeveral agencies came to the rescue of a horse that became trapped in a ravine near Palm Springs.
TV Plumber's Palm Springs Home Wrapped In Red, Orange VelvetA home for sale in the Palm Springs area is a red velvet time capsule from the 70s.
Will The Obamas Make Palm Springs Their Post-White House Home?And why not? Chicago has cold winters, Hawaii is far from the mainland. Palm Springs has lots of golf courses. Sounds like a no-brainer.
Missing 2-Year-Old Girl Safely Located In Palm Springs; Father ArrestedTwo-year-old Lucia Perry has been reunited with her mother.
5 U.S. Destinations To Escape The Winter ColdWinter is upon us and as temperatures drop across most of the country, it is time to make plans to get away. Escape to a destination where temperatures are a bit warmer and there are plenty of things to see and do.


text:
HINGHAM, Mass. – Acton-Boxborough scored just over a minute into the game and controlled the first and third periods to ease by St. Mary's, 4-1, at the Hingham Girls' Hockey Showcase at Pilgrim Arena.
The Colonials' depth was apparent as they were able to set the terms of engagement throughout and make the Spartans work harder for chances.
"The girls were really excited to play St. Mary's," A-B head coach Brian Fontas said. "Since I've been at Acton-Boxborough, I think we've played them six or seven times and haven't beat them yet. It's nice. They're such a great program, I have a lot of respect for them."
The Colonials were led by senior captain Annie Messuri. Messuri scored the opening goal of the game off a rebound and assisted on A-B's third goal with just over three minutes remaining to seal the victory.
Messuri led an offensive attack that only outshot St. Mary's, 23-18, but had far more quality scoring chances.
Megan Barrett scored for the Colonials to put AB up 2-0 just under four minutes into the game.
Leah Cardarelli had Acton's third goal, and Olivia Keefe buried an empty-net goal in the waning seconds from the neutral zone.
"I guess you could say that the first goal is important for our team," Messuri said. "It gives us the adrenaline to go into the game and all three periods more excited to play."
While scoring in the first minute was a boon for the Colonials it was a nightmare for the Spartans. St Mary's was on its heels for the final 44 minutes and was never fully able to push back A-B.
Samantha Callahan scored early in the second period to halve a 2-0 deficit, but that was as close at St. Mary's would get.
"I thought we came out flat and they took advantage of it," St. Mary's coach Frank Pagliuca said. "We've had an issue coming out stronger, and they scored a goal on us. Right away we're behind and playing catch up the entire game. I thought after the first we played a really good second. We just didn't have enough finish.
"[Callahan's] one of our more offensively talented players, and she finished the chance for us."
CLUTCH CALI: St. Mary's didn't have many top-notch chance,s but when they did Cali Loblundo was up to the challenge. The sophomore goalie shined for Acton-Boxborough turning aside 17 shots, including a Tim Thomas-esque dive across the cage in the second period.
"She's a big-time goalie," Fontas said. "She's capable of those saves. St Mary's didn't stop and I knew they wouldn't."
Loblundo chirped at her teammates all game about positioning and when Spartan forwards tried to sneak behind the AB defense. Messuri said having a confident goalie is a lift for the team.
"I thought Cali was great tonight," Messuri said. "She stood on her head for us when we needed her most. She hung in for us real well tonight and I'm real proud of her."


text:
Added by NicholsonClinic Subscribe 1
Published 20 Jul 2009
"The price became attractive," says Elaine Hampton, a victim of weight loss surgery abroad. "U...
"The price became attractive," says Elaine Hampton, a victim of weight loss surgery abroad. "Unfortunately they are not told the real story that the followup is going to be very difficult for them." says Doctor Nick Nicholson in Plano, Texas. "In general, what people need to realize is that if you go pay cash because your insurance company did not cover weight loss surgery, they not only do not cover the original surgery, they will not cover any of the complications. And that is a terrible problem for the patient when they get back." Elaine goes on to say that she was "throwing up constantly. I couldn't hold even water down." Hours later she was in a Plano hospital having emergency surgery. "You may think you are saving money by going to Mexico, you may have saved five or six thousand dollars, unfortunately that is about one trip to the emergency room," says Dr. Nick. Visit http://www.nicholsonclinic.com and read our blog at http://www.nicholsonclinic.com/blog


text:
Published on December 30th, 2013 | by Important Media Cross-Post0
Homemade Chocolate Made Easy
Have you been wanting to try your hand at homemade chocolate but weren't sure where to start? There's a kit for that!
Julie Finn over at our sister site Crafting a Green World shares a review of the Make Your Own Chocolate Kit. The kit comes from the folks who make Glee Gum, and it looks like a lot of fun! Julie used the kit to make homemade chocolate with her kids, and you can read her experience with it below.
Related Reading: Vegan Recipe:Deliciously Dairy-Free & Fair-Trade Chocolate Chips
What makes the kit sound super awesome is that you not only do you learn how to make homemade chocolate, but you get to learn about chocolate, so it's educational too! If you want to see how the homemade chocolate kit works and what Julie thought, you can read her review below!
Julie is also going to be giving away a homemade chocolate kit at Crafting a Green World tomorrow (December 31), so make sure you check over there and enter!
Ever wondered if you could make your own chocolate? You totally can! It turns out that chocolate is a pretty do-able DIY project, and easy to customize with your own mix-ins and flavor combinations. Never had a peanut butter/sesame seed/dried cranberry…
Keep up with the latest sustainable food news by signing up for our free newsletter. CLICK HERE to sign up!


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Item #: 2265501 Size: 6.8 oz
Excluded from coupons : This item is not eligible for coupon discounts.
Reviewed by 2 customers
Comments about Bvlgari Eau Parfumee Au The Blanc Body Lotion:
This is the Bvlgari fragrance that is used on the top floors of the Mandalay Bay in Los Vegas.
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Comments about Bvlgari Eau Parfumee Au The Blanc Body Lotion:
I am totally OBSESSED with this scent! My addiction began with the perfume and has carried over to every possible delivery method available, including the lotion. It's such a great scent - one that I get loads of compliments on - and it's perfect for every occasion, including every day use. Try it and you'll be hooked!!!


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37 years of experience
Covington, LA 70433 Phone number & directions
Patient Reviews
Patient Reviews ? Write a Review
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Great doctor - you never feel like he is in a hurry, he takes his time with you and he is fantastic with children. I have recommended him to several of my friends and they are all greatly pleased with the care his provides.
Dr. Rolston is wonderful, my only complaint is that I quite often wait over an hour after arriving for a scheduled appointment time. Allergy shots do not require doctor visit, so those are much quicker.
Great bedside manner.
my 10 son went to him to test for bee allergy. He wouldn't do the test. He did a scratch test and breathing test instead. Said he had asthma. He put him on an inhaler and nasal spray. My son 62 pound 10 year old lost 4 pounds and was lethargic by the time we came for a 6 week check. When I asked if the mess could cause this, he said no. They are improving his breathing, so they are making him feel better. After testing for mono, thyroid, iron, etc. I took him off of the Mede. He instantly got energy back and started eating. He had not shown signs of having trouble breathing before we went in and he continues to show no signs of breathing problems. I tried to schedule a meeting with him to tell him about the Meds so that it would not happen to other children. They said that the office manager would have to talk to me. No one ever called me.
Dr. Rolston is extremely knowledgeable of immunology & allergy. His experience is evidenced by his diagnosis & treatment plan. I've been a client for 20 years.


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PhoenixxTh... Model
Brickyard PhotographyPhotographer Male Columbia, Maryland, US
My Website: AJG/Brickyard PhotographyMy MM URL: http://www.modelmayhem.com/brickyardx
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About Me
If your looking to update your portfolio, get headshots, do some fashion, glamour and lingerie shoots, lets setup and appointment. I will be shooting both studio and locations shoots, which depends on décor and type of model.
One escort is allow at studio/location shoots. No cameras or pictures other than the photographer will be permitted.
For those models I have worked with in the past, lets hookup to do some new stuff this year. I will be travelling to different cities this year so all models I have not work with yet, I hoping to schedule something with you soon.
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CBNNews.com - JERUSALEM, Israel - A report on Israel's Channel 2 claimed that Prime Minister Ehud Olmert offered to cede 98.1 percent of Judea and Samaria (the West Bank) to the Palestinians.
According to the report, aired Sunday evening, Olmert made the offer in meetings with Palestinian Authority (PA) President Mahmoud Abbas, where the future division of Jerusalem has also been discussed.
Abbas reportedly has demanded that Israel abandon Israeli cities of Ma'aleh Adumim and Givat Ze'ev, but said he's willing to negotiate Jerusalem neighborhoods of Gilo and French Hill.
The report further stated that Olmert offered asylum to 5,000 Palestinian refugees, which Abbas reportedly rejected as far too small a figure.
Their discussions also include Palestinian access to the Dead Sea and the Kinneret (Sea of Galilee) so they could claim water rights because the Jordan River would run through a future Palestinian state.
Source: The Jerusalem Post
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The Terrorists Funded by the WestBassam Tawil
The New Israel Fund and those who support it are helping terroristsRonn Torossian
Column one: Fighting fire with fireCaroline B. Glick
Op-Ed: There is no 'radical Islam' and there is no 'moderate Islam'Dr. Mordechai Kedar
'Narrow' escapesRuthie Blum
Why Palestinians Do Not Want Cameras on the Temple MountKhaled Abu Toameh
Social Media Killed My FatherYoni Kempinski and Ari Soffer
Iran's New Palestinian Terror Group: Al SabireenKhaled Abu Toameh


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"Extremely graphic"
No - the scenes were too graphic with the torture of the main character
left more to the imagination
"South of Mediocre"
This is an uninspired story delivered in flashes of shocking, gruesome and unneeded details. About the best one can say about Heartsick: Sophomoric prose, undeveloped characters and flimsy plot lead to an ending. Many have compared the serial killer (heroine?) to Hannibal Lecter; that's quite a leap. Very little in this book that's believable, deep or interesting and some parts are actually painful to listen to, although because of the shoddy writing rather than the silly and mostly unnecessary torture and gore. No surprises or revelations, the characters just plod along to the ending you expected before the book was halfway done. Not sure why I stuck with it to the end - I guess I couldn't look away from the trainwreck, plus the book is thankfully short. The performance was mildly annoying but I decided it was more the source content that the voice artist herself. If you're looking for anything more than a trite distraction, do yourself a favor and keep looking.
Divorce attorney needing a break from reality!
"People are sick and we like it!"
When you look at your own self through the colored filter of any book, you wonder how you could gain the winning traits of the main character or lose a trait you have that is similar to the most heinous of the villains. Listening to this book made me start to see myself more as others must see me. It helped me to lay my own self bare. Therefore, my three (3) words are:
Heartsick (not because it is the title, but it is one of the best fitting titles I have seen in years)
I would have to relate this review to watching Silence of the Lambs. We all want to be able to have the power to create criminal profiles and to some degree, as a society, we have tied criminal profiles to the criminals they examine. I correlate the ability to climb into the head of a serial killer to having some maniacal traits of their own, no matter how utterly unfounded this is. Nevertheless, the desire to talk to a serial killer and come out on the smarter end is part of our collective narcissism and why we love murder mysteries to some degree.
Heartsick really meets the need of profiling by sitting you down with the serial killer, just like in Silence of the Lamb. Does she help? Will she eat your liver with beans? You'll just have to put your lotion on your skin, listen to the book, and see.
Unfortunately I did not have an extreme reaction, although I did enjoy the book thoroughly and wanted to listen to reach the end. However, when I finished the book and realized there was a sequel, I could not bring myself to buy it and continue with the character(s) in some of their sick relationships.
The psychological nature of this book is great. You will listen and not know the twists and turns you will take.
Wandah Panda
"She has a brand new fan."
Heartsick by Chelsea Cain
I absolutely adored this book and found it surprising all at once. I have never before read any work by this author but after listening to this book on audio I am sure to hunt down more of her work until I have read it all.
From The Beauty killer to the After School Killer this is a nonstop layered book fascinating me with deep character formations and a pull towards the next page like a morning body toward coffee. I needed my fix. I got it. Archie is a well rounded fluffed out character that at the same time managed to provide insight into what makes him tick and keep the largest part of himself secret as to create an enigmatic persona that the reader would want to get to know better.
The narrator Carolyn McCormick was stupendous in her narrating and never grating as some narrators can be at times.
The story is fast paced and intriguing leaving the reader guessing most of the time and the author does a stunning job of distracting the reader from the true facts by exploring the all too human side of the characters in depth. This however is never overdone and does not become tedious.
"Interesting Story, Excellent Narrator"
Gretchen is a villain I found both interesting and repulsive. It was an interesting story. I read the 2nd book first and it was good enough to get me to buy the 1st and 4th book on audible.
Part of the reason I decided to go for the 2nd book was the narrator. McCormick does a good job. I enjoyed listening to her.
Entertaining book if you like serial killer genre.
"Tested my patience"
It was a lot of rehash from previous book. I got a little weary of the demented relationship between Gretchen & Archie. It was just OK.
"Most Terrifying?"
This book might well be the most grisly, frightening, and yes---terrifying mysteries I've read in a long time. I'm a huge Stephen King fan and never thought I could be shaken up beyond anything he's written. But this book scared the heck out of me. Often I had to turn it off just because I couldn't listen to more grim details. The story is fascinating and certainly not like anything else I've read. And the narrator is just wonderful! There was seldom a time when I didn't know who was speaking, even though many of the lesser "cop" characters pretty much could be mistaken for one another. I guess the degree of sickness on the part of this serial killer is just this side of Hannibal Lechter, but because he is so "normal", he frightened me even more. I would definitely read more books by this author and this narrator. Be prepared to be scared!
"New narrator please"
This is a case of the book being let down by the narrator. There is a flatness to the narration which is irritating enough to detract from this gripping (at times sickeningly so) thriller. The dialogue was better done, but in 3rd person narration her voice didn't modulate when it should and it didn't allow you to lose yourself in the story when you should have been able to. I'll be avoiding this narrator though not the author who went places in her study of the psychology of evil which makes me wonder how she sleeps at nights!
Excellent Book, captivating. Chelsia Cain was a wonderful narrator. The story line was surpurb, I found myself captivated by the serial killers mind. I will listen to this book again. The characters were excellent. Many Heart stopping moments.
"Too Slow...."
Way too slow! I thought it would never end.


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Motorcyclist injured in crashJune 17,2013Staff Report
ARLINGTON — A Shaftsbury man was sent to the hospital with minor injuries after a crash on Saturday afternoon, according to the Vermont State Police.
Police believe Howard Guber, 75, of Kennesaw, Ga., was driving a 2007 Toyata Camry north on Route 7A in Arlington when he turned left in front of Eric Broderson, 44, of Shaftsbury, who was driving a 2009 KMT motorcycle, south on Route 7A.
Broderson unsuccessfully attempted to stop. His motorcycle slid into the rear passenger side of Guber's car as Broderson hit the pavement.
The crash was reported to police around 4:40 p.m. When they reached the scene, members of the Arlington Fire Department and Arlington Rescue Squad had already arrived.
Broderson, who was wearing his helmet at the time of the crash, was taken to the Southwestern Vermont Medical Center in Bennington with minor injuries. Guber, who was not injured in the crash, was issued a citation for failing to yield right of way.MORE IN This Just InMONTPELIER A pending deal between the state and federal governments will give a big boost to... Full StoryWOODFORD A North Carolina man was killed when his motorcycle crashed Friday morning in a... Full StoryMANCHESTER Voters will be asked at town meeting to allow the use of $15,000 from a reserve... Full Story
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Scipio Africanus Freeing Massiva (painting)
|Giovanni Battista Tiepolo
|between 1719 and 1721
|Oil on canvas
|279.4 cm × 487.6 cm (110.0 in × 192.0 in)
|The Walters Art Museum, Baltimore
Scipio Africanus Freeing Massiva is a painting depicting a scene from ancient Roman history by the Venetian artist Giovanni Battista Tiepolo.
In 18th Century Venice, Giovanni Battista Tiepolo was known for his monumental wall and ceiling paintings for palaces of the city's wealthy patrons. Scipio Africanus Freeing Massiva is recognized as a pivotal piece in understanding his mastery of this genre. The painting depicts Scipio Africanus freeing Massiva, the nephew of Massinissa, chieftain of eastern Numidia. This moment in history is described by the Roman historian Livy in his chronicle of Rome's struggles with Carthage. In 209 BC, at the age of twenty-six, Scipio campaigned against the Carthaginian general Hasdrubal (brother of Hannibal) in present-day Spain. At the Battle of Baecula, Scipio defeated the Carthaginians and captured their Iberian and North African allies. The Iberians were freed but the Africans were ordered to be sold. One of the Africans is brought before Scipio and identified as Massiva, a boy of royal blood. Even though Massiva's uncle, Massinissa, is an ally of Carthage, Scipio orders the boy to be released and returned to his uncle with gifts. This act led to Massinissa allying with Scipio when his forces landed in Africa in 204 BC.[1]
The original placement of the painting is unknown but it might have been one of the paintings for Giovanni Corner, whose family claimed descent from Scipio. The surface paint suffered damage but thorough treatment in 1996 restored the impression of bravura brushwork.[1]
Scipio Africanus Freeing Massiva depicts Scipio chastising the boy for disobeying his uncles orders to remain out of the battle and Massiva is seen turning away in humiliation. The details of the painting show Scipio sitting in gilded armor on an elevated seat, surrounded by what can be identified as Roman architectural features. The representation of the Roman state is confirmed by the standard being held by one of the soldiers bearing the abbreviation S.P.Q.R. (Senate and People of Rome). Massiva shown in gilded armor and manacles is presented as a European, which was conventional practice during the 18th century even though Tiepolo would have had the opportunity to study Africans in Venice. In contrast, the African boy to the left of the painting, identified as a servant of Scipio's due to his conversation with the soldiers, is depicted accurately.[1]
Off the Wall[edit]
Currently, Scipio Africanus Freeing Massiva is being featured in Off the Wall, an open-air exhibition on the streets of Baltimore, Maryland. A reproduction of the painting, the original is part of The Walters Art Museum collection, will be on display at the Clarence M. Mitchell, Jr. Courthouse.[2] The National Gallery in London began the concept of bringing art out of doors in 2007 and the Detroit Institute of Art introduced the concept in the U.S.. The Off the Wall reproductions of the Walters' paintings are done on weather-resistant vinyl and include a description of the painting and a QR code for smart phones.[3]
Further reading[edit]
- Christiansen, K, ed. (1996). Giambattista Tiepolo, 1696-1770. New York: The Metropolitan Museum of Art. (see index)
External links[edit]
- ^ a b c Hansen, M.S. (2005). Masterpieces of Italian Painting. Baltimore: The Trustees of the Walters Art Museum. p. 154. ISBN 0-911886-58-3.
- ^ Walters Art Museum - Off the Wall
- ^ [Smith, T., Walters Art Museum goes of the wall, The Baltimore Sun, September 11, 2012]


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Humorous Email Ad Design for a Website
This project received 11 bids from talented freelancers with an average bid price of $44 USD.Get free quotes for a project like this
Skills Required
Project Budget$10 - $30 USD
Total Bids11
Project Description
Design email advertisement for website. Ad should be humorous and convey the main capabilities of the site. People with experience designing memorable email ads are invited to apply.
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
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- Forbes
- The New York Times
- Time
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Numbers by tinytapps
By Altaf rehmani
Open iTunes to buy and download apps.
The world of Numbers comes to life via this app based on the wonderful ocean theme.
1. Numbers 0-10 : The child learns to recognize the numbers and also associate pictures with the sound of the numbers.
2. Tracing Numbers: The child learns to write numbers 1-10 .
3. Counting Numbers: Helps to evaluate and enhance the auditory and counting skills of the child.
4. Number Sequence: An activity that requires the child to recall and tap numbers in sequence 1-10.
5. Missing Numbers: As the name suggests, this shooting game is about Missing Numbers.
6. Number Song: The Number Song has numbers 1-10 shaking and tapping to the rhythm and rhyme.
Your little darling will enjoy the experience of interacting with the app while exploring the world of numbers.
Educational Consultant: Sajeda Jamal
What's New in Version 5.0
Fixed some minor bugs to be better and faster
- Free
- Category: Education
- Updated: 18 July 2014
- Version: 5.0
- Size: 41.7 MB
- Language: English
- Seller: Altaf rehmani
- © redbytes software
Compatibility: Requires iOS 6.0 or later. Compatible with iPhone, iPad, and iPod touch.


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Come visit me, Cookie loves his friends !, BC Library Now Open & Fly with the angels my Sally.
Come visit me, ~~Gus~~ & Chi chi RIP my sweet girl..
Come visit me, PaddyCake & PiddyGirl, CORI & BOO BOO.
Come visit me, Sugar ~ Thanks for all the AWESOME Memories.
Come visit me, Gabbie, Kallie, Peepers & Dixie.
Come visit me, Pearl & Silver.
Come visit me, ALEX has moved to YouPet., POPEYE has moved to YouPet., SAWYER has moved to YouPet., BLUE & JEWEL have moved to YouPet., GINGER has moved to YouPet. & CALICO has moved to YouPet..
Come visit me, CYDNEY "LOVES HER RAFFI", SAM, Angel Cinnamon (R.I.P.), STORMY & PRINCESS LOVES HER TWEETY.
Come visit me, Jedi says Happy Spring, Snowflake says...Happy Spring, Tweety says Happy Spring & PANTHER SAYS HELP ME GET TO 10K. ALMOST THERE !.
Come visit me, Buddy, Peanut, Rio, Ducky, Fred & Ethyl & Petrie.
Teri, Joliet, IL.
Ron & Dee Ann, Bellevue, NE.
Come visit me, ***Chipper***.
Ronnie Lee, Charlotte, NC.
Come visit me, Angel Bertie's Rainbow Gym: Thanks for BOTD!, Angel Bertie: Happy New Year!, Chirps: Happy New Year!!!, The Happy Couple!!!, Spot: Vote Mikey D for May BOTM,276082 & BonBon and Parker:Vote for BOTM!.
Come visit me, ANGEL LOVES CORI & PEPPER LOVES ZIPPY--BOTD 9/2/16!.
*Content generated by our loyal visitors, which includes comments and club postings, is free of constraints from our editors' red pens, and therefore not governed by I-5 Publishing, LLC's Gold Standard Quality Content, but instead allowed to follow the free form expression necessary for quick, inspired and spontaneous communication.
The last news and tips on everything pet bird.
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Email a Friend
WC cracks down on bad cops
Western Cape police management on Thursday said there was a steady increase in complaints against officers...
Western Cape police management on Thursday said there was a steady increase in complaints against officers in the province.
Police encouraged the public to lodge complaints.
Over the 2010/2011 financial year, 1,932 complaints were registered in the Cape.
From April 2011 to March 2012, 2,121 complaints were lodged against the police.
However, Deputy Police Commissioner Sharon Jafta said while she was concerned by the increase, she was heartened by the fact that more community members were taking action.
She explained by lodging complaints, police could improve their services.
Most of the complaints relate to police brutality and negligence.
Meanwhile, the Independent Police Investigative Directorate (IPID) on Wednesday announced 12 members of the Hawks would face criminal charges following the death of Sidwell Mkwambi in 2009.
It is alleged he was tortured so badly, he died from his injuries.
The new police directorate has promised to be more thorough with the cases it probes.
(Edited by Lindiwe Mlandu)
More in Local
'The goings on at the SABC are an embarrassment'
Police: Abalone worth over R45 million seized in 2015/16 financial year
Lit cigarette may be behind deadly CT fire
CT cop allegedly rapes woman in custody
'NPA should be shielded from undue political interference'
#Fees2017: 10 students arrested in Rhodes University protest
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Unity R&D Project
This project received 15 bids from talented freelancers with an average bid price of $51 AUD / hour.Get free quotes for a project like this
Project Budgetmin $50 AUD / hour
Total Bids15
Project Description
We are a 3D visualisation and digital media company based in Sydney. Our area of specialisation is creating 3D content targeted to the property market. We have experience developing touch screen PC and Flash based applications, however we are now looking into ways to showcasing our 3D animation using iPad apps.
We are currently in R&D phase of a project where as we could potentially use unity. This may be a standalone application or an add on to an existing app. Either way, we are keen to speak to developers to understand potential costs and workflows.
The types of jobs that we would be working to create would be quite similar to the following example.
[url removed, login to view]
If this is you, please get in touch.
Kind regards,
Looking to make some money?
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- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
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Free personalized radio that
plays the music you love
Mann Gegen Mann
Features of This Trackpop metal qualities
a subtle use of vocal harmony
call and answer vocal harmony (Antiphony)
extensive vamping
minor key tonality
a vocal-centric aesthetic
dirty electric guitar riffs
a breathy male lead vocalist
an aggressive male vocalist
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
Similar Tracks
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text:
Original Modern Textiles
$200 .
Seller Description: Original Modern Textiles from Finland. Blue and green is reversible colors on other side and we have a yellow and black textile with orange accents. great condition.$200 each
Contact Seller
Please Report Responsibly:
Advertiser Profile
Joined February 2011
3 classified ads currently listed.
Call Me: (818) 353-9519
Glendale, CA, 91208
More from Jerilyn
$50 .
$100 .


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Shearman & Sterling
|Pro Bono Rank
(Am Law 200 Rank)
|Am Law
Pro Bono Score
|Average Pro Bono
Hours Per Lawyer
|% of Lawyers
With More Than 20 Hours
Shearman & Sterling (26)
Arusha, Tanzania, doesn't appear on Shearman & Sterling's letterhead list of nineteen branch offices. But the firm is a constant presence there, sending one associate virtually every month since mid-2001 to clerk for the International Criminal Tribunal for Rwanda. Throw in the occasional training seminar for prosecutors or firmwide research project, and the firm's cumulative donation to the ICTR approaches an astonishing 40,000 hours.
"The breadth and length of Shearman's commitment to international justice is unique," says former Arusha prosecutor Simone Monasebian. "We at the ICTR benefited from the visiting lawyers' fresh perspective, analytic ability, and willingness to work long hours," says former chief of prosecutions Stephen Rapp. "They were happy for the break from their usual legal work and truly excited about the chance to help strengthen international justice."
Frederick Davis, who is now a partner at Debevoise & Plimpton, recalls his first trip to Arusha, in September 2000, to explore the possibility of a relationship. "I imagined it would be a boondoggle 'show up and take pictures' sort of thing," but the underfunded court's needs were acute, and Davis found himself writing a ten-page memo in the Nairobi airport laying out a vision for the program. Davis and his partner Stephen Fishbein organized four seminars between 2001 and 2005, where leading U.S. lawyers could instruct Arusha prosecutors from civil law nations on techniques like witness examination. From time to time, they also harnessed the firm's resources for global research on key issues like the tension between press freedom and incitement to genocide. In 2001 Daniel Schimmel, now a partner at Kelley, Drye & Warren, took a sabbatical at the court. The firm decided to institutionalize the clerkship that he improvised, and began to rotate an associate through Arusha every month.
Rapp notes that most alumni of Shearman's Arusha office take a few days to climb Kilimanjaro or safari to Ngorongoro. But it is not the safaris that are recalled in interviews with associates. They tend to dwell instead on the horror of the testimony that they heard or, especially, their encounters with everyday Africans.
Stephen Penner, a midlevel in asset management, taught his African colleagues how to make s'mores while dressed in a Tanzanian soccer jersey at a dress-as-your-favorite-country party held in Shearman's Arusha house. After hitching a ride on a U.N. flight from Arusha to Kigali, New York litigator Paula Howell experienced a truly global cultural moment with a young Tutsi woman who had survived the unimaginable, bonding wordlessly in a nightclub over a loud rendition of "Turn Me On," by the reggae artist Kevin Lyttle of St. Vincent and the Grenadines. For Andreas Kafetzopoulos, the memory that lingers came over dinner at the home of a Tutsi man on the shores of Lake Kivu. The young antitrust attorney from Brussels was moved to discover that two of the other dinner guests were the recently released murderers of his host's brother and two nephews. For Kafetzopoulos, the most searing lesson of his experience at a court devoted to retribution was the human capacity for forgiveness.
"Virtually everyone who went was blown away by how real it was," says Davis, who began his own career as a Peace Corps volunteer West Africa. "Everyone I talked to sort of had their life changed." In a few cases, literally so. Irina Dragulev took a few years off from Shearman to join the prosecution of Slobodan Milosevic in The Hague. Leslie Haskell became the Rwanda researcher for Human Rights Watch in Kigali.
Prosecutors stress that the overburdened court, where even stationery is rationed, benefits immensely from the program. Monasebian says Shearman's help was crucial in obtaining her seminal 2003 convictions of three leading Rwandan media figures for genocide and conspiracy. She vividly recalls preparing five experts on short notice at Shearman's Paris office, and then, with no notice, hijacking their best bilingual associate to Arusha.
Monasebian would urge other major law firms to "adopt" an international institutionbut she fears that Shearman's dedication is hard to recreate. When she reached out to other firms, in an effort to create a similar program for the defense team in Sierra Leone, she could not find any takers.
Michael D. Goldhaber | July 1, 2009
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