text:
Every now and then, investors may want to add a speculative piece to their portfolio. While it's not a great idea to go all-in on some of these companies, there's nothing wrong with a small position in your portfolio. While you could lose everything, the potential returns could be tremendous as well. Here are five speculative names to consider now.
Dendreon Corporation (NASDAQ:DNDN)
I mentioned that Dendreon would be a name to watch this week because of its earnings report, and surely I was right. Dendreon on Monday afternoon reported its second quarter results. I'll admit it, the results were not good. Dendreon reported revenues just under $80 million, while analysts were looking for about $85.8 million. Unadjusted earnings per share came in at a loss of $0.65, with the adjusted loss at $0.61. Both figures missed the $0.59 loss that analysts were looking for.
But the hope for Dendreon relies in the restructuring plan that Dendreon also announced. Dendreon is looking to cut some of its operating expenses as well as its cost of goods sold. It already has seen some improvement, because last year's second quarter loss was $0.79. While analysts don't expect much improvement in profitability this year (a $2.23 loss versus 2011's $2.31 loss), analysts are expecting the loss in 2013 to only be $1.38. Should this restructuring plan work, maybe they can only lose $1 per share.
Dendreon shares plunged to $4.76 on Tuesday, something I said would definitely happen if results were weak, and they were. This stock probably would be at $4 if the restructuring plan had not been announced, because that's how bad the Q2 results were. But the promise of a better future is giving some investors hope and keeping shares from dropping too much right now. Shares could still go towards $4 in the next few weeks, but Dendreon is trying to move in the right direction. However, it can only cut so many costs. Right now, the company needs to increase sales of its prostate cancer treatment Provenge. Those sales are not meeting expectations right now, which is why shares have fallen from more than $17 since February. I don't think Dendreon can get back to last year's highs around $45 anytime soon, but if this name can start to show some progress, I don't think it is out of the question for Dendreon to get back to $15 or $20 in the next couple of years.
Coinstar, Inc. (NASDAQ:CSTR)
Shares of the coin counter and video and game rental name have been hammered in recent months, and I think that provides a nice opportunity for investors.
Coinstar's reported revenues of $532 million missed by $13 million, but earnings per share of $1.25 beat by 6 cents. However, guidance was mostly in-line. Q3 revenue guidance of $550 to $575 million was above expectations for $545 million. It appeared that seasonality led to soft Q2 sales that would be made up in Q3. Earnings per share guidance of $1.09 to $1.24 was mostly in line with expectations of $1.17. For the full year, revenue guidance of $2.21 to $2.31 billion was a little light compared to expectations of $2.28 billion. Earnings per share guidance of $4.60 to $4.90 was in-line with expectations of $4.74. The company did state that swapping out some of the NCR kiosks would result in some extra expenses, but that these costs were not applicable to its "core results." Thus, they are a one-time issue.
Coinstar shares had backed off their 52-week high near $72 in recent weeks and were just above $59 going into earnings. That was a 17.5% decline in itself. But Coinstar fell $8 after the earnings report, and has dropped another $4 since then, putting shares just around $47.50. It has now lost more than a third of its value since the 52-week high, and the guidance wasn't really terrible. I think Coinstar's drop has been a bit too much, and I would expect shares to rally back towards the mid $50s over the next month or two.
Shaw Group Inc. (NYSE:SHAW)
Shaw Group announced an agreement Monday to be acquired by Chicago Bridge & Iron, now known as CB&I (NYSE:CBI). Under the terms of the deal, Shaw shareholders would receive $41 in cash and $5 in equity (0.12883 shares based on a CBI price of $38.81). It isn't 100% clear if you will get $5 in equity or the 0.12883 shares in the end. Usually in these types of deals, you will get the 0.12883 shares. I don't think they will change the share ratio at closing, which is expected to be in the first quarter of 2013.
But the interesting issue here is that Shaw shares are trading well below the purchase price. In fact, they are well below the $41 cash value of the transaction, and that ignores the additional stock portion of the deal.
I put together the following "deal table", showing where Shaw shares theoretically should be based on CBI's price and a 0.12883 share ratio. The "gain" column represents the gain you should make, dependent on where CBI shares are. At the moment, you should be making more than 5% just on the cash value of the deal.
|CBI Price
|Cash Value
|Stock Value
|Total Value
CBI closed at $35.74 on Tuesday, meaning that Shaw Group shares should be trading at more than $45.50 right now. But Shaw Group shares closed Tuesday under $39.
This is called a "merger arbitrage" play, because the acquired name is trading at a deep discount to where they should be. Some investors may not be convinced that this deal will go through, and remember, Shaw shares were below $27 before this deal was announced. Should the deal not go through, expect shares to head back down towards that level. But there's a good level of upside as well.
Zynga (NASDAQ:ZNGA)
The social game company has taken a beating since reporting its second quarter earnings. Shares are under $3 now, losing 50% of their value in 6 weeks and well off the high of $15.91 set in March.
I covered Zynga's earnings recently, and yes, guidance was not pretty at all. For the full year, Zynga expects bookings (revenues) in the range of $1.15 billion to $1.225 billion. Analysts were expecting $1.44 billion. Zynga expects non-GAAP earnings per share to be in a range of $0.04 to $0.09, well below the $0.27 expected.
But at this point, the bar has been lowered so much, and the stock has been hit so much, that it may provide an opportunity for investors looking for a long-term speculative play. At under $3 currently, the stock is basically a long-term option. When you look at this name in a few years, either you are going to lose all $3, or this name could gain a few hundred percent. There's even been some rumors out there that Facebook (NASDAQ:FB) may just buy Zynga at some point. With a current market cap of just over $2.1 billion, Zynga wouldn't be too large of an acquisition for Facebook, or maybe even a private equity firm. While these social media names have been beaten down, Zynga is definitely a good speculative play at these levels.
Netflix, Inc. (NASDAQ:NFLX)
Netflix provides a good opportunity for a speculative short-term trade, but I am not recommending this as a long-term buy. As I detailed last week, Netflix is not very strong right now.
However, as you can see from the following chart taken from Yahoo Finance, Netflix always seems to rally after these large scale drops, one of which we've seen since the latest earnings report.
Click to enlargeClick to enlarge
A couple of the latest moves in Netflix were from $120 to the low $60s, and we've seen a few moves from the upper $80s to the low $60s as well. Netflix dropped from $80 to $60 after earnings, and has lost another couple of dollars since then. I wouldn't be looking to purchase shares just yet, but if we get down to the $45 to $50 range, I might buy some for a quick trade. Netflix always seems to rally due to short covering or some hourly streaming metrics that the company boasts about each month. Even if the name goes from $50 to $60, you're looking at a 20% return. I still am recommending Netflix as a good long-term short opportunity, described in detail in the article above, but for a quick speculative trade, I think you can pick up $5 to $10 of profit if we get a little lower.
Now remember, I am recommending all five of these names as speculative plays only, and some of them just as short-term trades. I would not base a large portion on your portfolio on any one of these names. Also, all of the price data used in this article was as of Tuesday midday, so prices could and probably will change before publication. Keep that in mind, and before entering any of these names, all investors should do their own due diligence. I wouldn't bet the farm on any of these names, but for a small piece of the portfolio, adding one of these as a "lottery ticket" type investment could be a wise decision.
Disclosure: I have no positions in any stocks mentioned, but may initiate a long position in NFLX, CSTR, SHAW over the next 72 hours.


text:
MTA Devolving Before Our Eyes
New MTA chief Jay Walder is called a "doody-head."By Dan Amira
New MTA chief Jay Walder is called a "doody-head."By Dan Amira
Another one may be coming sooner than expected.By Dan Amira
So did a lot of people.By Chris Rovzar
Really, don't even bother.By Lindsay Robertson
The agency surprises itself by having solutions already on hand to resolve this long-running, widely known problem.By Chris Rovzar
Oh. That doesn't seem right ...By Dan Amira
Even if the landmark warning signs say the train is far away, never fear.By Chris Rovzar
And forget about putting pennies in your mouth.By Chris Rovzar
More specifically, what's the most popular reading material on each line?By Dan Amira
But she won't give up. And neither will we.By Dan Amira
Things were actually better in the summer of 1904.By Sam Jewler
But that won't stop City Councilwoman Letitia James.By Dan Amira
He or she is probably a robber!By Chris Rovzar
Subway masturbators, naked photo shoots — this is the place to be.By Dan Amira
We know it's inconvenient, but is crying really necessary?By Dan Amira
No one is hurt, but there is a lot of "smoke and noise."By Chris Rovzar
Subway trains are more reliable. The trade-off, of course, is that children are driving them now.By Dan Amira
Looking back at 80 years of delays.By Sam Jewler
It's now 2016, or 2017, or, let's be honest, somewhere in the 2040s.By Dan Amira
With a new iPhone app, you'll never again have to labor to figure out where to stand on the subway platform. We kind of wish you did.By Dan Amira

subset: commoncrawl


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Web Application Engineer
Engineering | San Francisco, CA | Full Time
About TRUSTe:
TRUSTe is the market leader in privacy management solutions, enabling businesses to optimize their e-commerce, mobile, cloud, social, and advertising channels. We are best known for our green Certified Privacy Seal now displayed on over 4,000 websites (including Apple, Disney, Groupon, Verizon, and Zynga) and seen by millions of customers each year. We are experiencing rapid growth driven by the increased use of customer data to power new online channels like targeted ads, mobile apps, and cloud services – and the corresponding demands from consumers and regulators for more transparency and control over this data usage. Businesses turn to TRUSTe to build / protect their brand, maintain compliance, and increase sales. We have strong financials, are backed by leading venture capital firms (including Accel), and have a deep and talented executive team including veterans from AOL, HP, Double Click, Google, VeriSign, and Yahoo.This position is located is located in San Francisco (5th / Market a short walk to BART & Cal Train). Learn more at www.truste.com.
We feature a fast-paced entrepreneurial environment that places heavy emphasis on innovation, teamwork, and an ongoing commitment to making the internet a safe and productive place to do business. We work hard and we play hard. We have some unique benefits including a fully stocked kitchen; a ping pong table on our outside deck; a tranquility room to chill out in; a dart board where you can throw darts and win money instantaneously; scavenger hunts throughout SF and monthly gatherings. Of course we offer the traditional benefits – health insurance, a 401(k) with a match, life insurance, short term and long term disability and a competitive base and bonus program.
TRUSTe is seeking a talented, experienced Web Application Developer (Frontend Engineer) to join our engineering team. The Web Developer will own the User Interface of major website projects from inception to development and delivery, working closely with an agile team including the Visual Designer, Product Owners and Development team.
- Design and develop Web based applications for internal and customer use
- Own front-end layout and visual execution for TRUSTe
- Act as the technical expert for presentation technologies on the engineering team
- Contributing to presentation layer standards and practices as a part of the engineering team
- Contributing to testing and implementation approach for presentation layer
- Build reporting dashboards for internal and external use
- Act as subject matter expert on Web UI design and implementation
Personal Attributes:
- Self starter able to proactively solve problems and work as the sole developer on a major feature area
- Ability to design, develop, iterate on a rapid basis
- Ability to organize and manage multiple priorities
- Understanding of latest innovations, trends and emerging technologies in web user interface development
- 3 years minimum experience with Java based web applications, Hibernate and Spring MVC, experience with GWT is a plus
- Client side development on at least one successfully deployed high volume website
- Proficiency with basic algorithms, data structures and relevant time/storage tradeoffs
- Experience solving cross browser compatibility, optimization, and layout issues
- Experience with web page performance tools
- Working with the engineering team to create modular templates for better site manageability
- Design, develop, iterate on a rapid basis while organizing and managing multiple priorities
- Experience prototyping visually attractive and highly usable web interfaces
- Working closely with product team, other engineers, and designers
- Development experience using extensible web authoring tools
- Experience developing and implementing open source software projects
- BS in computer science or a related field, or significant equivalent experience
- Experience of working in a start-up environment
- Experience of Agile development methodologies
- Understanding and enthusiasm for the latest innovations, trends and emerging technologies in web user interface development
- Good working knowledge of SQL
- Experience with JQuery and/or several Javascript libraries and frameworks
- Mobile development experience a plus


text:
Little King's Story Hands-On Preview
Tyranny has never been so adorable.
With the press of the A button, the adorably squat Soldiers with giant helmets and the hoe-toting Farmers with equally large straw hats who were obediently following behind you rush forward and jump on the back of the skeleton-masked cow that's been terrorizing the countryside. They hang on for dear life as the maddened monster jumps up and down, but soon they manage to whittle down its life, and it falls over on its side, dead. A few Soldiers also died. Though Corobo, the story's little king, has just received his crown, the villagers are already willing to die for him...sort of. Since the lovely folk are still new to this whole "being ruled" thing (and you are new to ruling a kingdom), their loyalty only goes so far, and sometimes they get confused by your orders (issued by pressing the all-mighty A button). In the case of the skele-cow (one of the first boss monsters you take down in the game), the soldiers sometimes get scared and run away until you keep insisting that they fight. Later on in the game, when you've built up your relationship with a villager, they know exactly what you're ordering them to do and continue to fight until death.
You start off with only three villagers (what a small kingdom!), but they each have their own personality, and as you spend more time with them, they become loyal and their health increases -- essentially, they level up. They start off as ordinary villagers, but as your kingdom grows, different job buildings crop up for them to learn in. To send a villager into a profession, you just command him into that particular building. Later in the game, as you move toward your goal of growing your kingdom and unifying the surrounding realms under your banner, you have the ability to continually send villagers into a job building and train them for a more powerful version of the job.
Each job class has its own skills. For instance, Soldiers are better at fighting monsters, but they don't do as much damage to natural obstacles like tree stumps as Farmers do. Also, only Farmers can dig up the healing hot springs hidden around your kingdom. We've only seen a few of the available jobs so far, but judging from the screenshots, there are plenty more to come -- including some that have your citizens wearing cat ears. With up to an eventual 50 variously classed villagers in your party, you can do some serious damage.
When they're not trailing behind you, the townsfolk pursue their own lives, making friends and starting families. But once you call them, they drop everything they're doing to come with you on whatever adventure you have in mind. It's a little sad, because if that person dies, you'll have to attend his family's funeral, and if he has any children, they'll be crying in the corner. The kingdom's population never decreases, though, since every death coincides with an amnesiac person washing up on your shores. The downside is that the new person will be starting with a fresh slate -- no loyalties and no relationships.
You also receive anonymous letters from your citizens via the mailbox in the town square. Some of the letters appear to be nonsense, but as you get to know the villagers better, they provide insight into their overall happiness. And, of course, you also receive some hatemail -- letters by villagers who were happy doing one profession until you up and told them to change jobs, or complainers who feel that the kingdom is still too small for their liking. The letters also hint at what the citizens want from their kingdom. You need to pay particular attention, because on occasion, the town votes on how you should expand the kingdom. After a choice is given, you need to raise the Wii Remote to raise your hand (or not, if you wish to vote nay). If you're the only one raising your hand, or if a majority of the villagers raise theirs and your hand is kept down, your favor with them will decrease. So it's important to keep their letters in mind if you want to have a smooth ride to world domination.
We're a little disappointed that the game lacks a few customization options, like letting you choose where to place new buildings rather than the preset way the kingdom currently grows, but so far, Little King's Story looks to be big fun, and we're eager to check it out more of it at this year's Tokyo Game Show.
See all Little King's Story Previews >
More RPG Games
More Wii Games
- Game:
- Little King's Story
- Platforms:
- Wii
- Genre:
- Publisher:
- Marvelous Entertainment USA/XSEED Games
- Developer:
- Marvelous Entertainment
- ESRB Rating:
- Teen
- Release Date:
- 07/21/2009
- Also Known As:
- Ousama Monogatari, Project O
1UP Editor Score: B-
Average Community Score: A
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text:
Can President Obama accomplish any of his remaining congressional goals before he leaves office? Probably not.
The newspaper urges readers not to vote for the GOP nominee, ending a 34-year history of neutrality in presidential elections.
President Obama joins dozens of dignitaries in Jerusalem at a memorial for the former Israeli president and Nobel laureate.


text:
Solutions for Chapter 2.C1
There are seven dimensions of organizational culture and many of them are required to be followed if not all. In the context of Toyota, "attention to detail", is the most important dimension to Toyota Motor Corporation.
This has been the long standing core value in company's culture. It is because of the high focus over the quality that Toyota lays. The level of quality that Toyota achieved was enabled only by having a very detailed attention to each and every detail of manufacturing process. But it was lost in the aggressive moves and ambitious cost cuts made by the company to achieve high-speed growth.
The culture of Toyota Company revolves around four principles-problem solving attitude, people orientation, philosophy and process. The idea behind these principles is if people think positive they eventually make a good product.
This type of culture is important for the company because it accounts for the internal and external environment. This environment Toyota offers to its employees promotes them to innovate. The core values the principles of production makes "Quality" as the most important factor. Since the automobile sector has a lot of competition, it is very important for a company to maintain quality and achieve cost-cutting simultaneously.


text:
Book A Service
Max Kirwan Mazda has a service facility capable of servicing in excess of 80 vehicles per day and is open from 7.30am until 6.00pm Monday to Friday and 8.30am to 11.30am Saturday.
Find out more
Welcome to Max Kirwan Mazda
Operating since 1946 Max Kirwan Mazda located in Preston is Melbourne's Premier Choice for buying and servicing your Mazda vehicle.
Max Kirwan Motors was founded by Max Kirwan Snr. who used his Army severance pay to purchase a handful of ex army trucks at an auction in Darwin in 1946. At the time there was a shortage of trucks in Melbourne as most had been moved north to support the war effort.
The only way to get vehicles to Melbourne from Darwin was to either ship them around the West Australian coastline or drive them through the Red centre of Australia. As shipping was very expensive and the drive through the Australian outback was filled with danger most people did not give the idea a second thought. More......


text:
Going to order it next month for the PS4. Not sure if im going to be able get the preorder stuff as its after the old systems/PC launch.
---------- Post added at 01:03 AM ---------- Previous post was at 01:02 AM ----------
Terrorist attack count against the Anything Goes Thread: 5
"Well, I guess in 2016 we're undefeated.....
.....hopefully we can stay undefeated.�
Dolphin�s owner Stephen Ross, January 4, 2016 after a season ending win; Dolphins finished 6-10; no playoff appearance
"....if there is activity in the ball prior to the rubbing action....
Bill Belichick, Sat Jan 24, 2015
"You may think that you are some kind of god to these people. But we both know what you really are."
"What's that? A criminal?"
"Worse. A politician."
Source: Under The Dome


text:
GWT enhanced text area component
This project received 4 bids from talented freelancers with an average bid price of $207 USD.Get free quotes for a project like this
Skills Required
Project BudgetN/A
Total Bids4
Project Description
Create a GWT component that will implement an enhanced text area component. The component should be usable as a text area, but there should be special tags which the user won't be able to delete or edit by using keyboard operations. These tags will be inserted using a special button (Insert tag). This will prompt the user to select a value from a dropdown list (a hardcoded list of values will do) and a text highlighted in yellow will be inserted into the component. THe user will not be able to delete or edit this (using the delete or backspace keys). The user will be able to click on the tags which will allow them to edit or delete them. The insert tag button will insert the tag at the position of the cursor.
Technical requirements:
The UI should be implemented using UI Binder
Proper software development best practices should be followed
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
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- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
Monday, September 26th, 2016
Amenities and Services
24-hour on-site staff
Apartment maintenance
Cable TV outlets/service in all apartments
Large common areas
Monthly health checks by nurse
On-site beauty salon
Pharmacy delivery
Planned activities
Private bathrooms
Three balanced and nutritious meals per day
Wall-to-wall carpeting
Weekly housekeeping/laundry
Emergency Response System in apartment, bath and throughout facility
Escort Services to and from meals and special programs
Snack Bar Open 24-hours a day
Transportation to local physician appointments
CrownPointe of Sebring
| Sebring, Florida
5005 SunNLake Blvd.
Sebring, Florida 33872
Phone: (863) 386-1060
Fax: (863) 386-4925
Assisted living for seniors has never looked so good! Professional landscaping and the tasteful decor of CrownPointe in Sebring offers both affordable "senior friendly" apartments and comfort. No stairs to climb and no maintenance worries allow seniors to focus on comfort, security and peace of mind.
We recognize that seniors have unique, individual needs and preferences. Three levels of services cater to each and every seniors need. Amenities and services are tailored to the resident's wishes. You only pay for services you desire!
*Independent Living
*Assisted Living
*Samaritan House assisting with special
programming for memory impaired
The Samaritan House offers individual apartment living in a specially secured environment. Allowing the highest level of independence within a safe, secure and comfortable setting.
We welcome you to tour and see what all the fuss is about!
Highlands County
- http://highlands-county.com/
Sebring Chamber
- http://www.sebringflchamber.com
Sebring Government Page
- http://www.sebringflchamber.com/government.htm
Sebring International Raceway
- http://www.sebringraceway.com/
Renee Marley, LPN - Executive Director


text:
Use these Black Luncheon Napkins for any occasion!
Our versatile Black 20 Count Luncheon Napkins measure 6.5 inches x 6.5 inches and features a textured border on two sides. These napkins are made of 2 ply paper and are sold in a package of 20. Add our Black Luncheon Napkins to your party tables.
Please allow ample time for delivery. Our ship date for this product is noted in your shopping cart. Many items are shipped separately, so please allow extra time for these items to arrive. Shipping charges are based on the value of the merchandise and not the number of shipments. For additional shipping information, please contact our Customer Service Department at (email@example.com or 1-800-314-8794).
Reviewed by 1 customer
Best Uses
Very good product
Service and delivery comments:
Quick delivery


text:
Wednesday, June 18, 2014
Holladay House Publishing announces Christopher Watsons author tour for The Handyman, the first paranormal murder mystery in the John Wright book series.
Christopher Watson will be attending events and signings on June 15 at Blue Bicycle Books in Charleston from 3-5p.m. and on July 6 at Books-A-Million in North Charleston from 1-4 p.m.
Other dates and locations for the remainder of Christopher Watsons summer book tour will be announced. For up-to-date information, please visit, www.holladayhousepublishing.com.
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Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
Popular mobile games often take a long time to arrive on Windows Phone - if they ever make the trip at all. Last year I wrote an editorial explaining the delay in porting games to Windows Phone and the market situations that make such delays inevitable. To make a long story short, bringing games from iOS and Android to Windows Phone at the same time as the lead version often doesn't make financial sense for the publisher… Not that we have to like it.
In fact, one of our dedicated readers doesn't care to wait-and-see whether popular games like Candy Crush Saga will make it to Windows Phone at all. Tjecco been running a forum thread dedicated to contacting mobile developers about support for Microsoft's mobile OS for a while now. With the help of other fine readers, he continues to reach out to developers and update the thread with their responses. Find out which developers have recently confirmed Windows Phone support (and what you can do to help) after the break!


text:
- IBMQA Engineer, 2008 - present
Technology Simplified
Apple Watch Review & Giveaway
Like the iPhone before it, everyone was talking about the Apple Watch long before it was announced by the company themselves. Shortly after
Technology Simplified
Fitbit Surge Review and Giveaway
Wearable fitness trackers can enhance fitness. But only if you work out. Don't expect a health tracker to act like a personal trainer; they
Motorola Nexus 6 Review and Giveaway
The latest entry in the Nexus line of reference devices comes with a steep, $650 price tag. Along with its Apple-like pricing, the Nexus 6 s
HTC Nexus 9 Tablet Review and Giveaway
The Nexus 9 just landed, and it's hot – both in terms of newness, and temperature. It offers the beefiest specs in the Android world, along
MSI GS70 StealthPro-024 Gaming Laptop Review and Giveaway
When we think of top-of-the-line gaming computers, we generally gravitate towards desktops. Quite simply, they come with beefier hardware th
Southern Arizona Gamers Association | TableTopDay.com | April 5th, 2014
2nd Annual TableTop Day Rincon Fundraiser and Poker Tournament! Join us again for the 2nd annual TableTop game day and Rincon Fundraiser. We
TechBargains: Best Deals, Dell Coupons, Cheap Laptops, Computer Sales
Techbargains.com - Technology products shopping guide. Find dell coupons, discount computers, cheap digital camera. Find cheap ipods, cheap
Phoenix Coyotes
20112012 Phoenix Coyotes 2011-2012 Regular Season Stats: 1 Games Played, 0 Wins, 1 Losses, 0 Overtime Losses , 0 Points
Astrid Task/To-do List
Astrid: Perfect personal to-do list Even better when shared with friendsAs millions of users have discovered, Astrid is more than just the p
Smurfs' Village - Apps on Android Market
It's up to you to build a new village for the Smurfs to call home. It's up to you to build a new village for the Smurfs to call home. PLEAS
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LastPass is a free password manager and form filler. LastPass is also available for Firefox, Internet Explorer and Safari.
Dilbert comic strip for 07/02/2012 from the official Dilbert comic strip...
The Official Dilbert Website featuring Scott Adams Dilbert strips, animation, mashups and more starring Dilbert, Dogbert, Wally, The Pointy
Netflix loses 800,000 US subscribers in third quarter
Netflix's subscriber attrition in the wake of a price hike and separation of its streaming and DVD businesses is even greater than first tho
How to Build a (Nearly) Hack-Proof Password System with LastPass and a T...
It seems like every day there's news that a new site or service has been hacked. The intruders make off with usernames and passwords, and ev
Board-game geeks have plenty of moves at RinCon
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Robert Ludlum's The Bourne Legacy (Bourne Series #4)
Available in:NOOK Book (eBook), Paperback, Hardcover, Audiobook. Timed to coincide with the feature film release of The Bourne Supremacy, st
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Google Authenticator
Enable 2-step verification to protect your account from hijacking.Google Authenticator generates 2-step verification codes on your phone.Ena


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Guns Sounds PRO
by: ArtostoLab • 5.4K
All Android applications categories
All Android games categories
by: ArtostoLab • 5.4K
Guns Sounds PRO - don't search anymore, this is the beast guns (shots) sounds app on Google Play Store.
Created for maximum entertainment this app contains almost every gun sound with high quality pictures and greatly designed UI that looks like a battlefield. For the best experience Guns Sounds PRO uses phone vibrations (however it can be easily turned off).
Scroll over different guns, pick your favourites and prank or even scare your mates!
Every gun (shot) sound can be easily set as a phone ringtone, notification (sms) sound or alarm (you will not oversleep again - guaranteed ;)), just hit "tune" image inside app. To add gun sounds to your favourite section click on "star" image, to remove from favourites - click again. To show your favourites guns click "favourites" button in the bottom - right corner.
Guns Sounds PRO main features:
* High quality sounds
* High quality Images
* Battlefield-like UI
* Easily set any gun as a ringtone
Guns included: AK47, AWP, Airplane Bomb, Desert Eagle, Flash Grenade, Glock, Grenade, M4, MP5, Revolver, Rocket Launcher, Scout, Shotgun, Silencer, Tazzer, USP
Tags: звуки оружия для андроид , приложение звуки оружия , звуки оружия на андроид , metralhadoras png , sonidos de pistolas gratis , звуки оружий на андроид , armas sons de armas pro , sons de armas , развлечение оружия на андроид
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from 5.373 reviews
Download Guns Sounds PRO
Free - V3.3 - 9M
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Top Definition
Epicly awesome and amazing. If someone is Zore, you have found one of the greatest people who ever lived. People who are Zore are good-looking, talented, kind, funny and have a magnetic personality that makes you want to be around them.
"Man, that Sydney girl is so cool."
"She's more than cool! She's Zore!"
"She's more than cool! She's Zore!"
από The Balladeer 31 Αύγουστος 2011
Trending Now
Can you define these popular missing words?
synonym for 'zero'.
από pitz 31 Μάρτιος 2004


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6 Comments
daletheskater Artist from Australia
nicely done! +1
Thanks, guys!
great song and great design! +1
if you have a minute pls help my design young giant http://www.designbyhumans.com/vote/detail/218389
oh shit ! i want to wear it +1 from me!
my latest design actually up for voting, please give me feedback and support if you like it, thanks !


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Industrial Conglomerates
Company Overview of Access Industries, Inc.
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BRADENTON, Fla. - Tom Gorzelanny took the first step in putting his disappointing 2008 season behind him.
The Pittsburgh Pirates' left-hander worked out of a jam and tossed two scoreless innings in a 5-2 loss to the Atlanta Braves on Friday.
Last season, Gorzelanny was supposed to be the Pirates' ace. But, overweight and out of shape, he went 6-9 with a 6.67 ERA and spent much of the year at Triple-A.
Atlanta's Kenshin Kawakami pitched two solid innings in his spring debut. He retired six of seven batters he faced, allowing just a single by Adam LaRoche.
"I think it went well for being my first outing," Kawakami said, through a translator. "When I face my own team, I don't have that mentality of being aggressive. But today against the Pirates, I was able to be aggressive."
Kawakami spent the past 11 seasons with the Chunichi Dragons of the Japanese Central League. Because of a back injury, he pitched only 110 innings last year.
Notes: Pedro Alvarez, the Pirates' top draft pick last year, made his first start of the spring. He replaced designated hitter Eric Hinske, who was a late scratch with a left ribcage bruise. Hinske expects to miss up to a week. ... Atlanta third baseman Chipper Jones hit a two-run homer in the fifth inning. It was Jones' first game in Bradenton since 1990, when he was in rookie ball. Greg Norton also homered for the Braves. ... Paul Maholm, the Pirates' ace and the only starter with a guaranteed spot in the rotation, is slated to throw two innings Saturday against Houston.
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Analytical Tools are cancer area specific intelligence and surveillance toolkits within a select number of hot, emerging cancer therapy areas. They are designed to empower biotech/pharma professionals ...
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P3-B power plant's groundbreaking in Naga: Koreans, Japanese lead ceremonies
By JASON B. NEOLA
Bicol Mail
NAGA CITY — A team of workers from the City Environment and Natural Resources Office (City ENRO) is now doing site preparations in Barangay San Isidro, here, for the scheduled groundbreaking of the P3-billion waste-to-energy plant on November 22, this year.
Highlighting the groundbreaking rites is the burying of a time capsule that contains some data on the project – the construction of a garbage-resourced power generating facility.
The facility will be constructed in a five hectare expanse on the foot of Mt. Isarog, now with a new perimeter fence.
Mayor John G. Bongat said the construction of the power plant will immediately commence a day after the groundbreaking rites.
Stakeholders expected to attend the ceremonies are the city officials led by Bongat, community leaders, the Korean investors from CJ Global Corporation, Ltd., and six technical men/consultants from Hitachi Zosen Corporation, a Japanese multinational engineering and electronics conglomerate company.
Based on the original plan, the state-of-the-art facility, which will be the first of its kind in the country, will start to operate by the first quarter of 2014.
The Korea-based CJ Global Inc., the project investor, had already paid 30% of the total cost of the machineries that will be deployed to convert into green energy the city's pile of daily garbage thru the process called gasification.
At the same time, the technical planning group of the foreign firm is busy working out the technical details of the facility's design. The plant's construction – one of the final steps of pre-operational phase – will commence once the site development is completed.
Bongat said that other than producing low-cost and environment-friendly electricity for the residents, the facility will also help the city adapt to an excellent garbage disposal management.
Once operational, the plant is expected to generate eight to ten megawatts of electricity from 100 tons of garbage collected daily. The plant has the capacity to process up to 200 tons of waste to produce 18 megawatts in expanded operations.
Orozco said that at least 25% of the daily garbage requirement will be sourced from the Balatas dumpsite. "It is not surprising if five or six years from now, the dumpsite is emptied of garbage," Orozco said.
Waste-to-energy (WtE) is the process of creating energy in the form of electricity or heat from the gasification of waste source. It is a form of energy recovery. Most WtE processes produce electricity directly through combustion, or produce a combustible fuel commodity, such as methane, methanol, ethanol, or synthetic fuels.
- November 15th 2012
- Posted in Environment, News, Technology
- 2 Comments
Bicol Habitat eyes bamboo house
Bicol Mail
THEY came in long sleeve shirts and arm cover, wearing buri hat or the malapad na sombrero, with sun-block cream applied on exposed parts of their arms and hands if only to lessen the bite of the sun on them for being exposed for hours to the elements.
They are volunteers lending their hand and hours to Bicol Habitat, a local organization of a cross-section of society affiliated to Bicol Habitat for Humanity International whose mission is "seeking to put God's love into action by bringing people together to build homes, communities and hope" for those who have less of these in life.
This time Bicol Habitat is into building model bamboo houses, designed by architects from Nepal.
Already, Bicol Habitat has come up with one model bamboo house in barangay Balatas in the City of Naga, and more are coming if a bigger lot is available. This model bamboo house sits on a 6×6 square meter lot, have bamboo posts, bamboo walls, bamboo girders, and GI sheets roof. Nails are not used to tie the posts and girders, but J hooks. Such a house is preferred by the urban poor and even by members of PagIBIG as it is bigger than the regular Habitat housing unit of 20 square meters.
- September 13th 2012
- Posted in Environment, News
- No Comments
Pedicabs for garbage collection
By Gerald O. Enguero
Bicol Mail
Pedicabs, or mobile carts powered by foot pedal, have been devised to provide a more efficient and speedier way of collecting garbage, initially at the public market here.
At least five units of pedicabs, which cost P14,423.60 each, have been initially dispatched at the Naga City People's Mall (the renamed city public market) after it was formally launched last July 2 by City Mayor John G. Bongat and personnel of the Solid Waste Management Office (SWMO) headed by Engr. Joel Martin.
Engr. Martin said that the new innovation is in line with Mayor Bongat's instruction to attain a 100% collection efficiency in the city's garbage collection.
"Before, the market cleaners used the conventional wooden cart which was heavier and took a lot of effort to collect garbage around the market's three floors. The use of pedicabs, which are speedier because they are lighter, will save more time and effort on the part of the cleaners and thus deliver their jobs well," Martin added
When the scale model was first presented to him, Mayor Bongat requested that his photo and name be removed from the vehicle design.
"I'm looking for long term function of the vehicles which are designed to upgrade garbage efficiency in Naga City that's why I instructed to remove my picture image and name on the vehicles because my term is just temporary while the use of this kind of innovation should be on a long term," said Bongat.
- July 19th 2012
- Posted in Environment, News
- No Comments


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By Rabbi Aaron Gol...
October 22, 2012
When faced with a couple who love Mancs Indie you got to rise to the challenge. So I got in:
This Charming Man (The Smiths), the North Country Boy (The Charlatans), said to the My Beautiful Friend (The Charlatans) for She Comes in the Fall (Inspiral Carpets) let's Come Together (Primal Scream) with Heart & Soul (Joy Division).
But xxxx, you weren't marrying Sally Cinnamon (Stone Roses) or Elizabeth, My Dear (ditto) and of course there is She's Lost Control (Joy Division) & Love Will Tear Us Apart (ditto) so lets get onto safer territory!
A record number of songs mentioned in a Wedding Address?


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Welcome to the PSYCHLOPS website.
Find out more about PSYCHLOPS here.
Copies of PSYCHLOPS questionnaires are available:
• here (pre-therapy)
• here (during-therapy)
• here (post-therapy).
A short introduction to PSYCHLOPS can be viewed here.
You may need to right click and "save as" to download the documents.
What's new for 2016?
We have made some changes to this site; if you are a regular visitor, you may need to clear your cache or refresh your browser to see the latest version.
On September 1st 2015, we made all access to PSYCHLOPS free of charge. PSYCHLOPS has always been free for charities, social enterprise organisations and researchers. In legal terms, it will be copyleft (not 'copyright') which means that it can be copied freely but not changed without permission from the authors. We are hoping that access and uptake of PSYCHLOPS will be greatly enhanced by making it completely free.
We are also exploring the options for developing an electronic version of PSYCHLOPS. There are considerable issues of data protection to be resolved but we hope to have answers later this year.


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Pat Howard: Saint Vincent agrees to takeover to counter Hamot's upper hand
Over the years as Erie's two biggest hospitals considered the prospects for consolidation, first with each other and then with out-of-town outfits, leaders of Saint Vincent Health System publicly ranked maintaining the legacy of the nuns who founded it as a primary concern.
In the end, keeping the Sisters of St. Joseph of Northwestern Pennsylvania at the heart of the 137-year-old hospital's mission didn't make the cut in the pitiless fight Saint Vincent is waging with a surging UPMC Hamot and market forces. A deal Saint Vincent unveiled last week will, if it passes regulatory muster, put the good sisters out of the hospital business.
The deal calls for Highmark Inc. to infuse $60 million into Saint Vincent over the next three years to "maintain financial soundness" and upgrade facilities and technology. The Sisters of St. Joseph will get $5 million to support the order's capital needs on the way to walking away from their hospital's governance.
The arrangement raises all kinds of questions about what's next for Saint Vincent and the Erie region's health-care market, but who will call the shots at Erie's oldest hospital isn't one of them. Highmark's cash buys it the right to appoint 75 percent of Saint Vincent's board of trustees.
The picture emerging is one of an iconic Erie institution swamped by change, dealing from a position of weakness and left to agree to a takeover by a Pittsburgh-based insurance giant with deep pockets. Since Saint Vincent remains Erie County's fourth-largest employer, here's hoping it works.
The dynamic would have been very different if the people leading Saint Vincent in the late 1990s hadn't pulled the plug on a different deal. That one would have consolidated Saint Vincent and Hamot into a single health system and altered the chain of events that culminated in 2011 with Hamot affiliating with the University of Pittsburgh Medical Center.
The agreement was close to complete when Saint Vincent officials decided they couldn't live with conditions imposed by the state Attorney General's Office. After Saint Vincent killed the deal in 1998, Hamot CEO John Malone said the two hospitals had "missed an opportunity here that I'm absolutely convinced will never come our way again."
It's possible even that consolidation would have amounted to a holding action, and that the combined health system would have ended up being swallowed by bigger players anyway. But now it's all but certain that from now on the most important shots at Erie's two biggest hospitals will be called from Pittsburgh.
The collapse of the 1998 consolidation deal sent Hamot and Saint Vincent back to their familiar, no-holds-barred struggle for competitive advantage and market share. As I reviewed dozens of Erie Times-News reports tracing the arc of what's happened since then, there was no ignoring the pattern of Hamot steadily getting the better of things on its way to passing Saint Vincent in patient revenue and employment.
And as market and political forces pushed our region's biggest medical players into the arms of behemoths, the results to date stand as one more instance of that. Just look at the two hospitals' consolidation deals and recent financial performance.
Highmark has agreed to kick in $20 million to stabilize Saint Vincent's books and another $40 million in capital investments over three years. That's serious cash for a hospital that in 2011 canceled the bulk of a $35 million renovation and expansion project.
But Highmark's investment doesn't begin to match the resources UPMC is bringing to bear at Hamot. Their 2011 deal calls for UPMC to invest at least $300 million in facilities and technology at Hamot over 10 years.
Hamot's upper hand is evident also in the two hospitals' balance sheets. The timing of last week's events set up UPMC and Hamot officials to crow about a record year just a couple of days after Saint Vincent laid out its plan to mop up the red ink there.
At its annual meeting Thursday night, Hamot announced it had collected a record $474 million in net patient revenue in the 2012 fiscal year, up $35 million from 2011. That translated into a $10 million operating profit, up from $169,000 in 2011.
Saint Vincent, meanwhile, posted an $11.9 million operating loss in the 2011 fiscal year. While the hospital hasn't released specific results for fiscal 2012, CEO Scott Whalen said it made "significant progress" but still lost money.
Saint Vincent and Hamot are caught up in a larger game of hardball between Highmark and UPMC as the two giants jockey for position in the hospital and insurance businesses throughout western Pennsylvania. There are a lot of financial and political variables in play in that competition, and in the overall economics of health care, that are hard to game out at this point.
Highmark's cash infusion certainly will give Saint Vincent some breathing room as it works to change its trajectory. Whether it's enough remains to be seen.
Write to Managing Editor Pat Howard at 205 W. 12th St., Erie, PA 16534, or e-mail him at firstname.lastname@example.com. Follow him on Twitter at twitter.com/ETNhoward.


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Walleye: The Location Factor DVD
Item # 438727
Key Features
Join Al & James Lindner on a fishing journey
Includes tips on adapting to crafty walleye
Learn to use a variety of rigs and electronics
Our Price $14.99
Availability: Sold Out
Prices, promotions, styles and availability may vary by store and online.
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Product DescriptionJoin Al and James Lindner and the Angling Edge Staff in the hunt for seasonal walleye hot spots. Includes tips on adapting to changing walleye locations throughout the seasons, implementing a variety of rigs to bring in jumbo walleyes, fishing in reeds and standing timber, and using advanced electronics to reveal walleye hideouts.


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This post is an oldie-but-goodie. It was shot last year, but I just love it because, first of all, it's a styled shoot with a boy, and many people tend to hit a wall in their brainstorming when it comes to styling concept shoots for their boys (it always seems girls are easier!).
My plan began with the book, a score from a local antique shop. The ideas mounted, and my friend Hilary had the perfect little man for these photographs. She had her grandfather's antique planes and a great old trunk, and her boy had imagination and wonder. He was so excited to scour the book to find planes within that resembled the ones he held in his hands.
A beautiful sunny day and an open field completed the concept.


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Recording of a Japanese friend performing a portion of the Nichi Ren morning chant. Recorded with two Joe Meeks microphones to a Korg D16 digital recorder.
Thank you! Nice one ;-)
This is just perfect.
I plan to use this for a Soundcloud track of mine.
I can post the link as well. I just love Japanese Culture. :)
I used this sound in www.youtube.com/watch?v=I7tugXr0MpE
Thanks and Happy New Year.
Enchanting! Would also love the wave.
Wow. this was unexpectedly amazing. thx
Please log in to comment


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Providing your body with a healthy probiotic source can be one of the most beneficial things you can do for your health. Pro-Biotic Complex by Klaire Labs is a specially formulated blend of bacterial strains to allow for maximum probiotic potential in the body.
Derived from an inulin base of chicory root' the probiotic blend includes both Lactobacillus acidophilus and Bifidobacterium bifidum ' combining to include over 5 billion CFUs. These two strains are known for their powerful potential' and able to break down digestive enzymes and support fermentation and break down processes. Both strains work to support healthy intestines' in turn promoting healthy digestion and toxin elimination.
Each bottle of Pro-Biotic Complex contains 100 capsules. Talk to your healthcare professional to determine the amount of capsules right for you. PureFormulas offers free shipping for Klaire Labs products!
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose' treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size 1 Capsule
Amount Per Capsule
Probiotic Blend 22 mg *
Lactobacillus acidophilus 2.5+ billion CFUs *
Bifidobacterium bifidum 2.5+ billion CFUs *
*Daily Value not established
Other Ingredients: Inulin base derived from chicory root' vegetarian capsule (hydroxypropyl methylcellulose' water)' and L-leucine.
As a dietary supplement take one or two capsules daily or as directed by a physician.
Consult your healthcare professional.
Allergy / Dietary Needs
- Artificial Color Free
- Artificial Flavor Free
- Casein Free
- Corn Free
- Dairy Free
- Egg Free
- Fish Free
- Gluten Free
- GMP Certification
- Milk Free
- Peanut Free
- Shellfish Free
- Tree Nuts Free
- Wheat Free
- Yeast Free
- Artificial Preservative Free
- Soybeans Free
- Vegetarian Capsules
Ratings & ReviewsReview This Item
Overall Rating for Pro-Biotic Complex™ - 100 Vegetarian Capsules
Displaying reviews 1-7 of 7
By ejones
from new york city
Not as potent as previous product
I bought Pro-Biotic Complex by Klaire Labs several years ago and the product was better then (what else is new...). It had 3.0 billion PLUS of both Lactobacillus acidopilus and bifidobacterium bifidum plus L-Leucine ascorbic acid and reduced L-glutathione.
Its just "OK" not reall good like it used to be...
As stated.
By Gleb
from OREGON CITY, OR
The best Pro-Biotic I've tried.
I've had IBD for five years. So over time I've had the pleasure trying all the possible naturapathic solutions to my messy problem. Probiotics were one of the first remedies on the list. In five years I've tried just about every proiobic product and finally have come to relly on Pro-Biotic Complex from Klaire Labs. Trust me these are the best probiotics on the market. If you have UC start out with three capsules with every meal combined with one capsule of PancreMax and your problem will be solved.
The Best!
√ I would recommend this item to a friend.
By christina
from Stamford, CT
Good deal for large # of strains!
Pro-Biotic Complex by Klaire Labs is my go-to product for probiotics. It has a large count and multi-strains. And for my food allergy kids its great as it has no common allergen fillers.
√ I would recommend this item to a friend.
By Scott
from Sun Valley, Ca.
Great Service!
Pro-Biotic Complex was delivered on time and the price was great.
√ I would recommend this item to a friend.
By Lisa
from Wilmington, North Carolina
great pro biotics
my doctor recommended this brand
√ I would recommend this item to a friend.
By Jennifer
from Charlotte, NC
Nice mild probiotic
My 11 year old son who has many allergies tolerates Pro-Biotic Complex well.
Clean from additives priced right
√ I would recommend this item to a friend.
By Linda
from Upper Peninsula
Recommended by naturopath
The Pro-Biotic Complex by Klaire Labs was recommended to me by my naturopath. It has also helped my friends. You have the best price & I love the free shipping.
√ I would recommend this item to a friend.
Displaying reviews 1-7 of 7
Questions About This ItemAsk a Question
Displaying questions 1-1 of 1
robin arrowsmith on 12/13/2015
Klaire's probiotics require refrigeration. How do you store them and how are the sihpped? Thank you,A
PureFormulas on 12/14/2015
Thank you for your question, Robin. This item is stored in a refrigerator in our warehouse. We recommend that it is shipped with our cooler service which includes a styrofoam cooler, ice packs, and expedited shipping.
- PureFormulas on 12/14/2015
Displaying reviews 1-1 of 1


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All of these offerings are available for Chapter and In-Company Programs.
These offerings may also be periodically scheduled for the Winter and/or
Annual Conference Education Programs, as well as the Online Seminar Series,
which takes place during the Spring and Fall of each year.
Chapters or
Companies: Contact Karen Murray, Manager of
Professional Development (firstname.lastname@example.com or 678-539-1146), for
more information about availability and scheduling an ALI seminar/course for
your organization
Availability: Check
the various offerings listed under Eduction & Certification to see if this course is being offered
ASHRAE advances the arts and sciences of heating, ventilation, air conditioning and refrigeration to serve humanity and promote a sustainable world. With more than 55,000 members from over 132 nations, ASHRAE is a diverse organization representing building system design and industrial processes professionals around the world.


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Experts in your field, Art's Way Ag designs and builds agricultural equipment for all hard working farmers. A tradition of quality since 1956.
With Art's Way Scientific custom modular buildings, you will get the facility that you need, the way you need it, when you need it. That is our promise.
Our reputation for product quality and innovation leads the way as Art's Way International expands its market reach into Canada and other countries. Providing service and products you can count on.
Through its tradition of innovation Universal Harvester Company has engineered a high quality Combine and Swather Pickup Reel. UHC is recognized for its reputation of honesty and integrity.
Art's Way Vessels is committed to providing our valued customers with steel pressure vessels that are built with consistent quality, delivered in a timely manner, and priced to keep you competitive in your marketplace.
American Carbide Tools manufactures cutting tools of uncompromising quality that deliver the ultimate in performance and value to our customers.
FOR IMMEDIATE RELEASE August 11, 2016 ART'S WAY MANUFACTURING ANNOUNCES DISCONTINUED OPERATIONS OF VESSELS BUSINESS SEGMENT ARMSTRONG, IOWA, August … READ MORE...
Conference Call Scheduled For Monday, July 18, 2016 at 10:00 AM CT ARMSTRONG, IOWA, July 12, 2016 – Art's Way Manufacturing Co., Inc. (NASDAQ: ARTW), … READ MORE...
Conference Call Scheduled For Monday, July 18th, 2016 at 10:00 AM CT ARMSTRONG, IOWA, July 15, 2016 – Art's Way Manufacturing Co., Inc. (NASDAQ: ARTW), a … READ MORE...
ARMSTRONG, IOWA, January 28, 2016 – Art's Way Manufacturing Co., Inc. (NASDAQ: ARTW), a diversified, international manufacturer and distributor of equipment … READ MORE...
To deliver high-quality, market responsive products and services which will exceed customer expectations and maximize shareholder value.
Art's Way Manufacturing Company, Inc.
Find stock information on NASDAQ: ARTW
PO Box 288
5556 Highway 9
Armstrong, IA 50514
Phone: 712-864-3131
Fax: 712-864-3154
Email: firstname.lastname@example.com
Copyright © 2016 · Art's Way Manufacturing Co, Inc · All Rights Reserved


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From the Department of Neurology (Drs Terwindt, Kors, Haan, and Ferrari) and Department of Human Genetics, Leiden University Medical Centre (Mr Vermeulen and Drs van den Maagdenberg and Frants), Leiden, the Netherlands; and the Department of Neurology, Rijnland Hospital, Leiderdorp, the Netherlands (Dr Haan).
Familial hemiplegic migraine is a rare autosomal dominant subtype of migraine with aura that in half of the families is caused by mutations in the CACNA1A gene on chromosome 19p13. In sporadic hemiplegic migraine (SHM), that is, hemiplegic migraine without affected family members, the contribution of the CACNA1A gene is unknown.
To investigate the involvement of the CACNA1A calcium channel subunit gene in SHM.
We screened 27 patients with SHM for mutations in the CACNA1A gene by a combination of single-strand conformational polymorphism analysis and sequence analysis.
One patient with SHM also had ataxia, nystagmus, and cerebellar atrophy on computed tomography and carried a T666M mutation. Another patient with SHM who had no cerebellar signs carried an R583Q mutation. No mutations or interictal neurological abnormalities were found in the remaining 25 patients with SHM.
Most patients with SHM do not have a CACNA1A mutation. The results of this study, combined with the findings reported in the literature, show that the presence of cerebellar symptoms in addition to the hemiplegic attacks increases the chance of finding a CACNA1A mutation. In addition, to our knowledge, we have found a first patient with SHM without cerebellar signs with a mutation.
FAMILIAL HEMIPLEGIC migraine (FHM) is a rare autosomal dominantly inherited subtype of migraine with aura.1 Patients with FHM have attacks of migraine with aura that are also associated with hemiparesis. Otherwise, the symptoms of the headache and the aura phase are similar to those of nonhemiplegic migraine with aura, but may last much longer. At least 3 different genes have been implicated in FHM: the CACNA1A calcium subunit gene on chromosome 19p13 in half of the families with FHM,2 an unknown gene on chromosome 1 in a few families, and at least a third one, as a few families could not be linked to either chromosome 19 or chromosome 1.3,4
In sporadic hemiplegic migraine (SHM) (ie, hemiplegic migraine without a history of affected family members), the cause is unknown. In 2 of 3 patients with SHM who have cerebellar signs that have been analyzed for mutations in the CACNA1A gene, a mutation was found; a T666M mutation in a patient with SHM who had cerebellar ataxia, and a Y1384C mutation in a woman with mental retardion who had recurrent prolonged attacks of hemiplegic migraine, coma, and seizures associated with permanent cerebellar ataxia and atrophy.5 Eight patients with SHM who had no cerebellar signs were analyzed, but no mutation was found.6- 8 In the present study we performed a mutation analysis of the coding exons of the CACNA1A gene by single-strand conformational polymorphism analysis in 27 patients with SHM.
As part of our ongoing mutation analysis of the CACNA1A gene, we studied 27 patients who had migraine with aura associated with hemiparesis. They originated from Western Europe, mostly the Netherlands, and one was from the United States. All available first-degree relatives were interviewed and their condition was diagnosed according to the criteria of the International Headache Society.1 In all patients with SHM, polymerase chain reaction products of all 47 exons of the CACNA1A gene were screened for sequence aberrations by single-strand conformational polymorphism analysis.2,9
Eight patients had no family member who had any type of migraine headache, while 19 patients had at least one first-degree relative who experienced migraine headache but none associated with hemiparesis (Table 1). Table 1 summarizes the clinical characteristics of the hemiplegic migraine attacks of the patients with SHM. The total duration of the migraine attacks varied between minutes and days, and even up to weeks in 2 patients. The paresis lasted between minutes and days, and weeks in 1 patient. In 2 patients the attacks fulfilled the criteria for basilar migraine.1 Two patients reported loss of consciousness during attacks, 1 patient reported confusion, and 2 patients reported attacks triggered by minor head trauma. Mutation analysis of the CACNA1A gene was unremarkable in 25 patients. One patient carried a T666M mutation (family 27). This 78-year-old woman had migraine attacks with aphasia, pyrexia, hemianopsia, and hemiparesis starting at the age of 14 years. In between attacks the patient showed gaze-evoked horizontal nystagmus and upgazed paresis, dysarthria, and mild limb and gait ataxia; cerebral computed tomography revealed cerebellar atrophy. Another patient carried an R583Q mutation (patient 26). This 16-year-old boy had had 5 migraine attacks with aphasia, hemiparesis, and confusion with a duration of half an hour followed by headache. No cerebellar signs were present.
We found a CACNA1A mutation in 2 of 27 patients with SHM. These findings are consistent with the results of other smaller studies showing mutations in the CACNA1A gene in 2 of 3 patients with SHM who have permanent cerebellar ataxia, and no mutations in 8 patients without ataxia.6- 8
We used single-strand conformational polymorphism analysis, which is a reasonable sensitive (70%-90%) method for screening genes for point mutations as long as the fragments are not longer than 200 bases.10 However, other types of mutations like microdeletions or macrodeletions are undetectable by single-strand conformational polymorphism. To investigate this, other techniques such as Southern blotting and/or pulsed-field gel electrophoresis should be used. However, the genomic size of the CACNA1A gene, 350 kilobases, makes it hard to apply these alternative methods in a standard (and rapid) mutation screening. The promotor region or other regulatory elements were not analyzed, as at this moment, these have not been identified. Other studies in sporadic cases of specific genetic disorders give similar results as our study; a positive test rate is usually low, ranging from 2% to10%.11
The patient in our study carrying the T666M mutation was distinctive from the others by showing permanent cerebellar ataxia and atrophy on computed tomographic scanning. Unfortunately, no DNA and direct information of the parents were available. The other mutation found in our study (R583Q), however, was found in a patient who did not have cerebellar symptoms. This R583Q mutation was reported previously in 4 families with FHM and associated ataxia.8,12 The mean age of onset of the ataxia is 40 years, ranging from 11 to 78 years.8 The patient with SHM in our study is only 16 years old; it is possible that he will develop these symptoms.
Clinical analysis of the symptoms of the aura in patients with FHM suggests an extensive overlap with basilar migraine.13 Only 2 of our patients with SHM had attacks fulfilling the criteria for basilar migraine. Unconsciousness during attacks and provocation of attacks by mild head trauma are not uncommon features of 19p13-linked families with FHM.14,15 In contrast, only 2 patients with SHM in this study reported these features. Thus, both genetic and clinical data suggest that FHM and SHM might be pathophysiologically different.
Accepted for publication January 7, 2002.
Author contributions: Study concept and design (Drs Terwindt, Haan, Frants, and Ferrari); acquisition of data (Drs Terwindt, Kors, van den Maagdenberg, and Ferrari and Mr Vermeulen); analysis and interpretation of data (Drs Terwindt, Kors, Haan, van den Maagdenberg, and Ferrari and Mr Vermeulen); drafting of the manuscript (Drs Terwindt, Kors, Haan and van den Maagdenberg and Mr Vermeulen); critical revision of the manuscript for important intellectual content (Drs Kors, Haan, van den Maagdenberg, Frants, and Ferrari); obtained funding (Drs Frants and Ferrari); administrative, technical, and material support (Dr van den Maagdenberg and Mr Vermeulen); study supervision (Drs Haan, van den Maagdenberg, Frants, and Ferrari).
This work was supported by nr 903-52-291 from the Netherlands Organization of Scientific Research, The Hague, and The Migraine Trust, London, England.
Members of the International Hemiplegic Migraine Research Group included the aforementioned authors and following persons: Neurologische Klinik der Ruhr-Universität, Bochum, Germany: J. Federlein, MD; Neurologische Universitätsklinik Regensburg, Regensburg, Germany: A. May, MD, PhD; Charing Cross Hospital, London, England: R. C. Peatfield, MD; Canisius Wilhelmina Hospital, Nymegen, the Netherlands: E. F. J. Poels, MD; Headache Center, Henry Ford Hospital and Health Sciences Center, Detroit, Mich: N. M. Ramadan, MD; Hospital de la Citadelle, Liège, Belgium: J. Schoenen, MD, PhD; Klinikum Grosshadern, München, Germany: A. Straube, MD, PhD; and Leeds, England: P. F. Taylor, MD.
Corresponding author: Michel Ferrari, MD, PhD, Department of Neurology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands (e-mail: firstname.lastname@example.com).
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The news is out that Bank of American (BoA) has $64 billion in mortgages that are at least 6 months delinquent and yet the bank hasn't pulled the trigger on foreclosure. If that doesn't seem like a lot, consider that $64 billion is almost half BoA's market cap.
ZeroHedge figures,
in other words, by keeping tens of billions of mortgages off the market, Bank of America is hoping to limit the supply of houses in the market, creating an artificial shortage, in the process pushing up the prices of all other house higher, and only then to start dumping its pre-foreclosure inventory to a witless housing market.
The $64 billion, reports Bloomberg, is more than twice the amount held by its four biggest competitors combined and is 3.3% of all the mortgages it services. Competitors like Citigroup and J.PMorgan Chase have around 1% of their mortgages in this category.
Most of the loans were originated by Countrywide, the falling knife BoA caught during the financial meltdown.
Back in 2008 it took an average of 367 days for a lender to work through the foreclosure process and secure the collateral. Now, reports Bloomberg,
Mortgages on U.S. homes at the time the borrower lost the property averaged a record 728 days late in October, up from 661 days a year earlier, according to Lender Processing Services Inc. in Jacksonville, Florida.
"With delinquent mortgages you want to triage them, work out ones that can be worked out and foreclose the ones that can't," professor Alan White tells Bloomberg. "But if the only outcome is no outcome, it's not helping any of the parties affected, including the economy."
For whatever reason, BoA seems to be moving slower at clearing their foreclosure pipeline than other lenders. Some borrowers were 500 days late before receiving a default notice and modification paperwork moves slow and is often lost at BoA.
The claim that the housing crisis is over gets more common everyday. But how does this market take off with 2.5 properties nationwide in the shadow foreclosure pipeline? ZeroHedge calls the "foreclosure stuffing" by BoA, Fannie, etc. the "most obvious housing subsidy in the last four years."
Enjoy the dead cat bounces while you can.


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How much longer are we going to have to put up with the cowboys who have barged onto the Malheur National Wildlife Refuge in Oregon, armed to the teeth and making demands? The situation is both comic and frightening, and it is easy to lose sight of the basic problem, which is livestock agriculture. What we need to do now is to act compassionately and vigorously to protect the wildlife refuge itself. Let's make the Malheur National Wildlife Refuge an actual wildlife refuge. This means enforcing the principle of law, but going further. We need to change the law and get the cattle out of Malheur completely. Continue reading
Category Archives: Politics, or the lack thereof
Public Lands Grazing Issue Provokes Armed Takeover of Government Building
Many people are now discussing the situation in rural Oregon, where a group of armed militants have taken over the headquarters of the Malheur Wildlife Refuge. The militants are supporting unlimited access of cattle ranchers to public lands and are apparently willing to use force. In an age where people snapping pictures of factory farms are accused of being "animal rights terrorists," it is going to be interesting to see how the government will react to what seems to be the genuine article — actual terrorists with actual guns.
Degrowth and Veganism
How can we deal with climate change, let alone peak oil, water shortages, deforestation, and everything else — given that truly effective environmental action would probably stop the economy from growing and totally change everyone's lifestyle?
Our whole economy depends on fossil fuels, and our livestock-centered agricultural system is pillaging the earth's biosphere. Veganism is surely part of the needed approach here. Continue reading
The Drought in California
The California drought is not going away anytime soon. And guess what uses more water than anything else in California? Livestock agriculture.
The environmental reasons for veganism suddenly are getting more credibility and attention. The recent film Cowspiracy, and the San Diego based group Truth or Drought, have drawn needed attention to the environmental destructiveness of livestock agriculture.
The solution seems to be obvious. Some people get it, while others don't. Still other people almost get it, but not quite. Continue reading
This Changes Everything — Review
This Changes Everything: Capitalism vs. The Climate, by Naomi Klein. Simon & Schuster, 2014.
For Naomi Klein, the climate change issue changes everything: the only way to deal with climate change is to change capitalism. We need fundamentally to alter our economic system if we hope to save the planet. Her analysis is spot on and I hope that climate change activists and vegans will study and benefit from this book. The only criticism I would have is not that it is too radical, but that it isn't radical enough. Continue reading
Moral Tribes — review
Moral Tribes. Emotion, Reason and the Gap Between Us and Them. By Joshua Greene. Penguin Press, 2013.
What's the best way to talk about moral issues? This is obviously something that activists worry about a lot, whether their cause is veganism, the environment, climate change, or anything.
According to Joshua Greene, the problem is not lack of basic morality, but in competing moralities. There are many different moral cultures or subcultures, which share among themselves certain ethical ideas which, to them, are obvious. But these ideas differ from those of other moral cultures — the "moral tribes" referred to in the title. Anyone who is interested in this problem, or in moral philosophy and moral psychology in general, should at least take a look at Moral Tribes. Continue reading
Soil Erosion — is anyone paying attention?
Over a month ago, Reuters issued a widely-mentioned (but not widely discussed) press release on soils."Only 60 years of farming left if soil degradation continues," reads the release. It quotes some United Nations officials, warning of the problems of soil erosion.
Is anyone paying attention? In an ideal world, the public would be outraged by this. Congressional committees would study the problem. Students would demand courses on soil preservation. But back in the real world, farmland just isn't that big of a deal. After all, agriculture is just a very small part of the U. S. economy. We could also debate whether this is an exaggeration. Perhaps we have 100, or even 200 years of farming left! Continue reading
How can we ask them not to eat meat?
In a recent Go Vegan radio interview, Leslie Goldberg (author of the Vicious Vegan blog) gave an account of a conversation she had with Bill McKibben. (McKibben is a noted environmentalist and a co-founder of 350.org.) Leslie asked McKibben why he didn't talk about meat consumption as a cause of climate change. McKibben first pointed out that most of the growth in meat consumption comes from the developing countries. Somewhat irritated, he then asked (in effect) "how can you ask people who are just starting to be able to afford and enjoy meat, not to eat meat?"
This is an intelligent question, so I thought I'd attempt to answer it. Continue reading
Peak oil may be almost here
"Predictions are difficult, especially about the future." This aphorism is nowhere more applicable than when predicting the date of "peak oil" — the maximum point of world oil production. In case you hadn't noticed, oil prices are falling dramatically. Until about six months ago, oil ("West Texas Intermediate") had hovered for several years in the region of $100 a barrel, reaching $107 on July 23. But by last Friday (December 12), it was below $60. If we're close to peak oil, and oil is getting scarce, shouldn't the price be going up? What happened, and why?
Chris Hedges: Go Vegan for the Planet
Chris Hedges was a war correspondent, worked for the Greens in 2008 and 2012, and was part of the "Occupy Wall Street" movement. He's also, interestingly enough, a Presbyterian minister. He is known to me personally mostly as the author of War is a Force That Gives Us Meaning, a book which is at once interesting, powerfully written, and quite disturbing. It was so powerful, in fact, that I couldn't finish it. Forcing myself to finish it would be like forcing a vegan to watch slaughterhouse footage. I get it already; I don't want to watch it.
Chris Hedges is also now a vegan, citing serious environmental concerns. He describes this in his recent article, "Saving the Planet, One Meal at a Time." Continue reading
Are We Scared Yet?
The economy in Colorado is doing well. Population is growing, driving up housing prices. Fracking, livestock, and debt are providing jobs. Unfortunately, these are the very factors which are devastating the planet.
Several months ago, Russian researchers reported a giant sinkhole in Siberia, on the Yamal peninsula. It was apparently caused by a huge and spontaneous release of methane from the permafrost, caused by the unusually warm summers in this Arctic region (about 5 degrees Celsius warmer than normal). Methane is a vital issue because it's a very important greenhouse gas, right next to carbon dioxide, and its importance is typically underestimated.
Let's put this in perspective: the permafrost is melting. Continue reading
Vegans at the local Climate Rally
"You vegans seem to be pretty well organized!" This is what one of the leaders of the Denver climate march said to Kate and me as we marched down the 16th Street Mall today. I had to smile. Basically, my "organizational efforts" consisted mostly in bringing just four signs. Each of the four had "Meat's Not Green" on one side, and "Less Meat = Less Heat" on the other. Kate, however, also had a considerable role in this; she had just given a short talk to the crowd about veganism, livestock agriculture, and climate change. Continue reading
The recently-concluded Denver event "Hoofin It" (August 17-20th) featured a different hoofed animal each day at different restaurants for customers to eat. The meat is from "responsibly raised hoofed animals," and it was a benefit for the Colorado Food Guild, and tickets were not cheap: $60 for dinner for one person. The theme of the event was "respect your dinner."
Had this been just another event of the "happy meat" people, vegans would have greeted this news with yawns and the ritualistic rolling of the eyes. But this event had an unexpected feature; the key sponsor was The Humane Society of the United States (HSUS). Continue reading
Al Gore is Vegan
Methane is a lot worse than we thought, but there is some good news about the climate as well, already well publicized. Al Gore has gone vegan. In the past many people have complained about Gore's lack of interest in combating a key cause of climate change. Well, now our hopes have been realized: Gore is a vegan. The "revelation" has been confirmed by The Washington Post.
This is a hugely interesting fact about which quite a bit of ink has already been spilled. The most interesting facet of this story is how amazingly little we know about Gore's veganism. Continue reading
Methane (Again)
There's bad news on the climate front. Methane emissions are quite a bit worse than previously thought. A new study published in the Proceedings of the National Academy of Science is now all over the internet and in the news. It shows that methane emissions are 50% greater than previous estimates from the Environmental Protection Agency. It's not only our consumptive lifestyle overall, but specifically meat consumption, which is the problem. Continue reading


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Fruit Shake
Total Time
Prep 5 mins
Cook 5 mins
Grab a straw on your way out the door! A cool, tasty treat, good any time, with vitamin C and calcium. Feel free to add to this, it only gets better! Change the flavors, by adding different flavors of frozen yogurt, and/or fruit.
Ingredients Nutrition
- 2 cups fresh peaches, peeled and sliced
- 1 cup strawberry, halved
- 1 cup apple juice, chilled
- 1 cup vanilla frozen yogurt
- Combine peaches, strawberries, and apple juice in container of blender or food processor, process until smooth.
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I'm such a smoothie consumer that I had all the ingredients needed for this GREAT TASTING DRINK (well, except that I used frozen fruit instead of the fresh kind, 'cause of the time of year) & it was put together in no time at all! ABSOLUTELY LOVED THIS SHAKE! [Made & reviewed in Healthy Choices ABC Tag]
WONDERFUL beverage to relax with on a lazy afternoon! The flavors of strawberries and peaches blend very well. I happened to purchase some fresh peaches since they are in season now and was able to use them. A thick and delicious shake. Prepared as a participant in the Zaar Chef Alphabet Soup Tag Game September 2009.


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Today is July 7, 2007, or 070707. Here is a quick look at how the No. 7 has factored into sports history:
Famous No. 7s who could go deep: Yankees outfielder Mickey Mantle and Broncos quarterback John Elway.
No. 7 car in NASCAR: Robby Gordon.
Pretty athletic guy: James Bond (007).
1977 team sports world champions: Yankees (MLB), Raiders (NFL), Trail Blazers (NBA) and Canadiens (NHL).
Tour de France wins in a row by Texan Lance Armstrong: 7 (1999-2005).
Hockey's famous No. 77: Hall of Fame center Phil Esposito.
On Thursday, Tiger Woods shot a 73 to tie for 77th place in the AT&T National.
The Cubs won the first of their two World Series titles in 1907, beating Detroit. Chicago won 107 regular-season games.
Five teams have scored 7 points in the Super Bowl, the last being the N.Y. Giants against Baltimore (2000).
West Texas A&M's Emily Brister enters this season as the Lady Buffs No. 7 all-time scorer. She has scored 30 or more points seven times and her low point output is seven.
Spurs star Tony Parker and actress Eva Longoria will be in 7th Heaven today ... they're getting married.
- Globe-News Staff
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Miyazaki doesn't believe player who says he finished Dark Souls without taking a hit
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Dark Souls Games For Windows to Steam transfer is now live
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The Games Of The Generation: Matt's Choice
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Send Up the Clowns: Parliamentary Sketches 2007-11 (Paperback)Simon Hoggart
Paperback Published: 28/09/2007
- In stock
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Simon Hoggart is known as the wittiest of all the parliamentary sketchwriters. For thousands of "Guardian" readers - and hundreds of politicians - his column is the first thing they turn to in the morning. This wickedly funny new collection takes us from the departure of Tony Blair to the arrival of the grumpiest prime minister in recent history, through the expenses scandal - with its duck houses, moat cleaning and porn films - to the last election and the arrival of a new premiere, David Cameron, the man who hates the condom on his head. Read how Vince Cable brought Gordon Brown down several pegs, how Brown claimed to have saved the world, about the chancellor so boring that he sent Geoffrey Howe to sleep, and about Sir Peter Tapsell, a grandee so grand that Hansard embroiders his work as tapestries. Learn what the Big Society really means, why Nick Clegg looks so miserable, and how David Cameron stops people kicking sand in his face. Forget academic studies - this is all you need to know about the politics of present-day Britain.
Publisher: Guardian Books
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The signs of many mental health and neurodevelopmental conditions first appear in childhood and diagnosis can reliably be made by school age for most. Such conditions can be chronically disabling and confer significant long-term impairment.
JCPP Editorial: Painting by numbers: using modern approaches to analyse and visualise clinical and research data
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St Saviour's House
39-41 Union Street
London SE1 1SD, UK
Tel: +44 (0)20 7403 7458
email: firstname.lastname@example.com