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This page contains Ridge Racer Unbounded Video Walkthroughs for Xbox 360 called "Walkthrough Part Tower Heights - The Domination" and has been posted or updated on Jun 14, 2012 by FrankNStein.
- Developer: Bugbear
- Publisher: Namco Bandai Games
- Genre: Racing
- Release: Mar 27, 2012
- ESRB: Teen
Walkthrough Part Tower Heights - The Domination
Watch this step-by-step Video Walkthrough, which may help and guide you through each and every level part of this game.
Please Submit a Problem for any incomplete, non-working or fake cheat listed above.
If you know other secrets, hints, glitches or level guides, then please Submit your Cheats and share your insights with other players.
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
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In-Crisis Consulting, LLC was founded by John Bruner:
1) Former Chief County Detective with the Greene County District Attorney's Office (Western Pennsylvania).
2) Former Negotiations Leader for the Washington Regional (Pa) SWAT Team
3) Former Criminal Investigator and a Police 1st Responder for 20 years.
John is a Subject Matter Expert (SME) on Active Shooter Incidents & Robbery Prevention.
- Certified Trained:
- FBI - Workplace Violence
- FBI - Crisis & Hostage Negotiator
- FBI - Concepts of Criminal Profiling
- FBI National Academy (PA Chapter) - Surviving a Critical Incident
- U.S. Secret Service - Characteristics of an Armed Gunman
- Miami-Dade Police Department - Officer Involved Shooting & In-Custody Death
- California University (PA) - Behavioral Analysis of Violent Criminals
- Slippery Rock University (PA) - Active Shooter & Threat Assessment
- Dept. Homeland Security - Crisis Management for School-Based Incidents
- FEMA - Incident Command Systems for Law Enforcement
- FEMA - Workplace Violence
- Has instruct alongside the FBI and the US Secret Service to numerous companies on offender & victim mind-set and violent crime prevention.
- Issued hundreds of media releases including the print media, radio, and TV interviews.
- Trained various industries: Universities, Hospitals, Financial Institutions, Pharmaceuticals, Retail, Fortune 500 companies, and local, state, & federal law enforcement agencies.
- Volunteer Programs: John educates and assists school districts Pro Bono on Active Shooter Violence & Child School Safety to give back to the community as these services usually push against a tight school district budget.
- Education
- University of Pittsburgh, B.A. Degree in Administration of Justice
- Indiana University of Pennsylvania, Police Academy , ACT 120
- Member Fraternal Order of Police -
email@example.com 724-350-1486

subset: commoncrawl


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10 Ways How And Why To Create Successful Events
One of the most important, yet most challenging, things that every business owner must do is get new customers and keep the ones they have. Organizing an event to bring your customers together is one of the most exciting and challenging things you can do. Here's some insight into why and how to create an event that turns your customers and prospective customers into passionate evangelists. Organize small events in your office: Have an open house on a regular basis inviting customers and prospective customers to come to your office to hear and discuss a particular topic. Don't sell your product or service at this gathering, but share useful information.
Provided by: American Express Topic: Big Data Date Added: Oct 2010 Format: HTML


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Wordpress and Joomla are ideal solutions for nearly every type of website. They are the most robust content management systems and are trusted by millions of webmasters world wide. Joomla in particular has been used by fortune 500 companies like Barnes and Noble, Ebay, Ikea..
Our complete SEO services include on-site / off-site search engine optimization with an emphasis in Youtube and advanced social media content marketing to create a branded in-bound network to increase your search engine postitioning and return on investment.
Long gone are the days of "build it and they will come" approach to internet marketing. In today's world, effective internet marketing requires SEO, PPC, Social, Email and more such as video, affiliate marketing, content marketing, social engagement, etc.
Social networks are ideal for establishing and growing your brand. Like all things internet, there are some quick and easy things to do, but to truly maximize your social brand requires a thoughtful plan, execution and continued management and analysis.
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To help our clients and general users, we have created a variety of tutorials to help you set up an effective social brand business page.
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We provide product photography and professional level real estate photography in Annapolis Maryland and surrounding metro including DC and Baltimore. View gallery, royality free interior and exterior photographs of properties we shot and contact us for a quote..


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The National Law Journal lists Cardozo among the top 50 schools with the highest percentage of 2015 graduates in what the publication describes as the "gold standard for lawyer jobs." The New York Law Journal says, "Cardozo Law Dean Melanie Leslie attributed the improving fortunes of its graduates to a 'top-to-bottom' review of its placement strategies as well as reviewing where growth is occurring in the New York legal market. 'The key has been understanding the job market and providing the right information and connections to our graduates,' Leslie said."
Cardozo School of Law and The International Center for Transitional Justice Partner on a Project on the Missing and Disappeared
Under the agreement, student participants of the clinic will review the evolution of these concepts and their legal implications, and share their results with ICTJ, an international organization that works in countries seeking to address legacies of mass human rights violations.
The Cardozo School of Law team of Jonah Brill '17, Sarah Griggs '17, Joseph Kammerman '16, Vino Jayaraman '16, Charles Manfredi '17, Liliya Perelman '16, and Madison Wiles-Haffner '17 won first place at the 2016 Tulane Mardi Gras Sports Law Competition in February 2016.
Congratulations to the Cardozo Law Review alumni whose notes were cited in December 2015 and January 2016.
Cardozo Journal of Conflict Resolution Presents International Advocate for Peace Award to Peter, Paul and Mary
In selecting Peter, Paul and Mary for the 2015 IAP award, CJCR recognizes the folk-singing trio's contributions and continued efforts to unify society through song and music. Peter, Paul and Mary's music resonates with history – a history that they not only helped write, but that has changed and inspired millions to maintain the principles of peace and tolerance in the face of war and great adversity.
Suleman Malik '16 discussed, as part of an on-air panel of Muslim Americans, politics, religion, civil rights, and his perspective in light of Donald Trump's comments and the recent terrorist attacks in Paris and San Bernardino. The story aired on CBS This Morning, CBS News and Face the Nation.
The New York Times - "They're all eligible," said Leslie Salzman, a clinical professor at the Cardozo School of Law. The school's Bet Tzedek Legal Services Clinic is suing the city along with JASA Legal Services for the Elderly in Queens and Northern Manhattan Improvement Corporation Legal Services.
The Cardozo Office of Communications & Public Affairs


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Adelaide Harmony Choir inc
Our next performance
Haydn's Creation
Established in 1947, the Adelaide Harmony Choir Inc. has been one of Australia's foremost large choirs for over 50 years. Its wide choral repertoire extends from oratorio and opera to operetta and songs. Each year the choir performs a number of concerts in Adelaide culminating in a traditional Christmas Carols concert. It has also made two concert tours of North America.


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Climate change and wine
We have noticed subtle alterations in our weather, and the changes that it has wrought worldwide. We have seen the calving of glaciers up north and the drowning of polar bears because they have no ice floes on which to swim. When I noticed a winemakers' conference on global warming, I began to wonder how climate changes would affect the wine industry.
Dr. Greg Jones, a climatologist at Southern Oregon University, predicts that by the end of the century, up to 81 percent of the country's high- to premium-end wine grape production zones will decrease. That is because by 2050, temperatures will increase by an average of 3.6 degrees across 27 of America's wine regions. By 2100, that number will have increased to 4.5 degrees in the west. Jones also predicts that there will be warmer and longer growing seasons, longer dormant periods and altered ripening profiles.
Jon Trumble, entomologist at the University of California at Riverside, said, "Insects don't have the ability to control their temperature. As the weather warms up, we're going to see an incredible increase in the number of insects. If we get more monsoonal rains coming up from Baja, we're going to see a dramatic increase in species of insects in California that we've never seen before."
While predictions are that the changes will not be experienced for around 40 years, some differences are noticeable right now. When we were in Germany in 1997, we spent a week along the Rhine and the Mosel Rivers. We came across tents indicating that the residents would be celebrating the harvest that night. We would stop, find a "zimmer frei" (available room) and party with the town. That is why it took us so long to travel that relatively small region. Whenever we would stop at an actual winery, the winemaker would eagerly bring out his spat burgunder, which is a German pinot noir. They were dreadful — it was not that they didn't taste like pinot noir; they tasted bad. Fast-forward to 2008: I have been treated to several spat burgunders recently, and they were delicious. When I queried, the purveyor would comment that the climate is warming so that the grape now has enough heat days to ripen in Germany.
The same thing is happening to the pinot noir in Oregon. It seemed as if the weather was only conducive to adequately ripening Oregon grapes about one year out of eight. It was like that fairy tale: When it was good, it was very, very good. When in off years, it was awful. Now Oregon is experiencing more good years than bad, and that state can realistically claim to have the best pinot noir.
Australian wines may be drying up. Australia is experiencing a six-year drought. While grapes do not need much water, they do need some. And while the 40-year estimate of the full impact of climate change is a ways off, Washington state will be spared from any detrimental effect on its wines. The weather will be favorable to great vintages. Canadian wines will also benefit. Canada has been producing better wines. Initially, its wines were green, tasting as if the grapes did not have a chance to ripen. Now that the Canadian vines are maturing and the weather is more favorable, their wines are much better.
Chris Howell, a former Mercer Island resident and Cain Cellars winemaker in California, is my go-to guy when I have questions. He responded immediately with various reports and studies. In the Napa Valley Vintners' publication, an article addresses the impending doom for the Napa and Sonoma Valleys. Succinctly, the prediction is that those areas will warm up so much that the grapes will ripen too quickly and fail to develop character and acidity.
Because of these dire predictions, the Napa Valley Vintners — a coalition of 325 winery members — has created a Climate Change Task Force, working with noted geophysicists from Scripps Institute of Oceanography. By developing a more accurate model, the coalition hopes to adjust farming practices to maintain Napa's leadership role in viticulture and winemaking.
In the short term, winegrowers can do a lot to curtail the harmful effects of climate change. Canopy management — how vines are pruned and trellised — is a critical method that can protect grapes from heat during the day. Leaf-thinning and shoot-pulling can provide greater air flow around clusters to curtail mold and mildew. These are just a few practices that can help keep the quality of grapes. Grapevines are adaptable and vineyard practices can minimize climatic effect.
Winemaker Chris Howell sums it up: "As you can see, it becomes more interesting as we bring it closer to home. And also it becomes less clear-cut, less proven, more speculative and more of 'soft science.'"
My husband, who is my personal pundit, predicts that we will see varietals such as the Spanish tempranillo growing in areas where it is currently too cool. He also forecasts that the French law against irrigation will eventually need to be changed. However, we probably will not be around long enough to see his predictions come true.
Gifts for the
wine lover
I am constantly asked about gifts for wine lovers. Usually, my suggestions are standard and not very exciting. However, I have two recommendations that will perk up your recipients.
First, there is the breathable wine glass. With mystical technology, the Eisch family of Germany has developed a breathable glass that enhances wine in five minutes. We tried this at home with a normal glass of about the same size and a breathable glass with the same wine. Within five minutes the wine in the breathable was softer and more fruit forward, as if it had been decanted for a much longer time. The Culinary Institute in California uses these glasses plus an impressive list of Washington winery tasting rooms: Barnard Griffin, Basel Cellars, Bookwalter, Columbia Crest, Chateau Ste. Michelle, Columbia, Gordon Brothers, Kestrel, Sagelands, Snoqualmie, Three Rivers, Tsillan and Walter Dacon. After all, they want you to taste their wines at their very best so that you take some home.
Aerating wine helps to mellow the tannin and alcohol, allowing the fruit to come forward both in the nose and mouth. Primarily true for reds, aerating also helps white to mellow out wood notes and dissipate acid.
One breathable glass in a protective cardboard tube is $25.
A pack of six glasses in a cardboard box is $125.
Another interesting gift is a one-year membership to Two Mountain Winery's "Vineyard Crew." Crew members tend to the winery's vineyards at four key growing periods during the year. Each session is accompanied by a lecture on seasonal topics such as pruning, thinning, verasion and harvest. The cost is $100 per person or $180 a couple. Call (509) 829-3900 or log onto www.twomountainwinery.com.
Dee Hitch can be reached at firstname.lastname@example.com.
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text: let's get the seven lines. (bookshop) wrote, 2013-01-13 06:01:00 let's get the seven lines. bookshop 2013-01-13 06:01:00 Previous Share Next update: I seem to be a verb I apologize for the lack of porn, but hey, at least there's a squash. Tags: fic, inception Comments for this post were disabled by the author bookshop: ←re: my opinion piece on fandom and the fourth wall bookshop: →Fight Like a Girl: a new fantasy lit Kickstarter Project!


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LA-based Optimist Design has completed a recording studio in Berlin for Red Bull, marking the latest addition to the energy drink company's network of music venues around the globe (+ slideshow). More »
Tag: Red Bull
Red Bull's Stockholm office features modular mobile furniture
The new Stockholm office of energy drink company Red Bull incorporates a range of flexible communal spaces, including a reception with a modular desk that can be reconfigured for use as a bar in the evening (+ slideshow). More »
São Paulo warehouse revamped into
Red Bull arts centre by Triptyque
Red Bull Music Academy by
Langarita-Navarro Arquitectos
Slideshow: Spanish studio Langarita-Navarro Arquitectos filled a Madrid warehouse with makeshift huts and a wilderness of plants to accommodate a nomadic music academy organised by drinks brand Red Bull. More »
Red Bull Amsterdam by Sid Lee Architecture
Inside awards: Red Bull offices
by Linda Morey Smith
In this Dezeen movie London interior designer Linda Morey Smith, one of the judges of the Inside awards, talks about designing the headquarters of drinks brand Red Bull. More »
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Check out this article from Forbes Magazine on Moziah Bridges, a young entrepreneur who started a bow tie company with the help of his grandmother. His idea has already made him over $30,000 and is continuing to grow! …Continue
Posted by Hunter Authement on March 21, 2016 at 2:00pm
Registration is now live for our regional business plan qualifiers! Don't miss the chance for constructive feedback, cash prizes, and the chance to advance and compete in the state competition! Registration links are located below!
Jackson -…Continue
Posted by Hunter Authement on February 25, 2016 at 1:30pm
The Southern Entrepreneurship Program (SEP) kicked off the spring semester by concluding its second round of annual events with symposium 2 "I Am My Own Boss"!
The second round of events were broken into three regions and consisted of state resource providers sharing…Continue
Posted by Hunter Authement on February 16, 2016 at 2:00pm
Posted by Hunter Authement on January 20, 2016 at 2:00pm


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The U.S. Highway 395 bypass through Carson City will be open tonight.
Crews placed an oil-based application on the road that will extend its life cycle, said Scott Magruder, NDOT spokesman. The work was set to continue tonight if necessary, but it was completed overnight Monday and early Tuesday.
"It's a rejuvenation. You want asphalt to not be too dried out," Magruder said of the process. "Sometimes it's easier to just close the road. And the weather was good, too. We had good temperatures."


text: LYF Youth Ministries at Sugar Creek Baptist Church includes both youth (grades 6 – 12) and college ministries. These ministries help develop tomorrow's Christian leaders at both the Sienna and Sugar Land campuses by going through four distinct areas of their walk with Christ. These areas are shown below.Remnant 115 website for information on college.


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An 18th century bronze ship's cannon was stolen from the front of a pirate treasure gallery on King Street, according to the gallery's owner.
Rich Mutschler, owner of Galleons Lost at 165 King St., said Monday that he put the cannon out in front of his store about 9 a.m. Friday and it was gone at 10:30 a.m.
Mutschler reported the loss to Charleston police in a report filed Saturday.
"We have been putting it out front for weeks," Mutschler said. "Nobody bothered it."
Galleons Lost has been open since April and offers pirate artifacts, art, shipwreck coins, gold doubloons, black pearls, gold treasure, fine jewelry and family heirlooms. Having a cannon out on the sidewalk helped people notice the store, Mutschler said.
"I think someone rolled it away from the front of the store and loaded it into a truck around the corner," he said.
The cannon was capable of being fired, he said. It is the type of gun that might have been deployed on a small East Indies ship.
The cannon is valued at $10,000 and weighs about 250 pounds, Mutschler said. It was three feet long and had the letters "VoC" on the top of the barrel. It was in a brown wooden carriage.
Reach David W. MacDougall at 937-5655.
To offer tips
Anyone with information about the cannon theft should call Charleston police at 577-7434 or Crime Stoppers at 554-1111.
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We Can't Say No to Sideboob
We Can't Say No to Sideboob Each an every men love boobs and they are beautiful from every angle, but believe me the side view is especially sexy. Here are 26 hot pictures of sideboob that will make...
Real Vs. Fake Boobs: A slow motion Video
The title says it all, it's a shakedown of real vs. fake boobs.
Ads That Have Nothing to Do With Boobs
JK. These are all about boobs! Via Buzzfeed
Huge Tracts of Land Get Em Now!
Some awesomely hilarious French guys put together this wicked site! It's a best-of instagram, featuring nothing but sweet sweet boobies.
Awesome Fit Girls
World's Largest Boobs
When we saw this video on the world's largest boobs, we got a little excited. Then we realized how big they actually are and they're not that awesome. They're kinda freakish. And the...
And the Winner of the Panty Poll Is…
The Cheeky! Thanks for voting bros!! It was pretty close, thongs put up a good fight and finished as a strong second. And as promised we have an entire post dedicated to lovely ladies in the winning p...
It's Gonna Be a Huge Year
To celebrate the start of 2012, we found some of the biggest boobs on the internet! Enjoy bros 🙂
Cats and Boobs!
Everything loves boobs, including cats apparently. Check out all these kitties motor boating these chicks!
Pics You Wish Some Girl Sent You
Oh hey bros. We have some crazy sexy pics of random hotties taking cell phone shots. Our favorite! We wish the ladies would send us these pics more often!!
Mandy Graff is Stupidly Hot
Mandy Graff is a super hottie from Luxembourg. We can't find a lot of info on her that isn't in German, but we think these pics say enough. Have fun kids. Thanks Funtasticus for the pics! ...
Melanie Iglesias Christmas Flipbook Preview!
Check out the video–Melanie is at it again! It's an awesome video, and I'm sure everyone will enjoy. This is only a preview, the full video will be out December 20.
Tan Line Thursday
Oh hey bros. So we're thinking of trying something new. We're gonna post pics of hot chicks with tan lines every Thursday. Sounds good? We thought so. Bask in the glory of the first 12 stu...
Hot Chicks! In Bikinis!
Winter is probably the saddest time of the year for bros. No chicks in bikinis! It blows. So to hold you over 6 long months til summer, we have some super hot chicks in bikinis.


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Hartford police investigate suspicious activityMarch 30,2013WILDER — The Hartford Police Department says it is investigating several suspicious incidents, including several reports of students being followed while they were walking alone.
Police say a teacher reported seeing three males following a female middle school student who was walking alone in Wilder. The teacher told police that she pulled over to talk to the student as a deterrent.
The three males then walked away and got into what is described as a gray van and left.
Police say another report came in that a male student believed he was being followed on Tuesday. And on Thursday, police received a report that three males in a gray van were watching juveniles at a Kilowatt Field in Wilder and allegedly held up what appeared to be weapon.MORE IN This Just InRutland got two goals from Eli Henni and Ryan McKay made three saves in notching the shutout as... Full StoryA New York woman allegedly told police she stole money from her sister to fund her drug habit. Full StoryA homeless man denied stealing his mothers wallet and using her credit cards to buy items to... Full Story
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From the Department of Otolaryngology–Head and Neck Surgery, Massachusetts Eye and Ear Infirmary (Drs White and Fabian); Wellman Laboratories of Photomedicine (Drs White, Rajadhyaksha, Gonzalez, Anderson, and Fabian) and the Department of Pathology (Drs Baldassano and Tearney), Massachusetts General Hospital; and Harvard Medical School (Drs White, Baldassano, Rajadhyaksha, Gonzalez, Tearney, Anderson, and Fabian), Boston, Mass. The authors have no relevant financial interest in this article.
Confocal reflectance microscopy (CRM) is an optical method of imaging tissue noninvasively without the need for fixation, sectioning, and staining as in standard histopathologic analysis. Image contrast is determined by natural differences in refractive indices of organelles and other subcellular structures within the tissues. Gray-scale images are displayed in real time on a video monitor and represent horizontal (en face) optical sections through the tissue. We hypothesized that CRM is capable of discerning histologic characteristics of different tissues in the head and neck.
To examine the microscopic anatomy of freshly excised head and neck surgical specimens en bloc using CRM and to compare the findings with those generated by conventional histologic analysis.
This was a pilot observational cohort study. Bone, muscle, nerve, thyroid, parotid, and ethmoid mucosa from human surgical specimens were imaged immediately after excision. Confocal images were compared with corresponding routine paraffin-embedded, hematoxylin-eosin–stained sections obtained from the same tissue.
Characteristic histologic features of various tissues and cell types were readily discernible by CRM and correlated well with permanent sections. However, in all tissues examined, there was less microscopic detail visible in the CRM images than was appreciated in paraffin-embedded histologic sections.
The CRM images revealed cytologic features without the artifacts of histologic processing and thus may have the potential for use as an adjunct to frozen-section analysis in intraoperative consultation.
Pathologic examination of tissue during a surgical procedure is typically performed by frozen-section preparation and subsequent observation under a light microscope. Studies have appeared frequently in the literature documenting the high accuracy rate of frozen-section analysis.1- 6 However, frozen sections are technically limited and often more difficult to interpret than paraffin-embedded permanent sections.4 Frozen-section preparation is also time consuming because of the tissue processing involved (freezing, sectioning, staining of the specimen, difficulties in obtaining an adequate thin section, and the possible need for additional frozen sections). These delays can contribute to increased operative time and cost and could potentially put the patient at risk for additional morbidity.
Confocal reflectance microscopy (CRM) is capable of noninvasive high-resolution imaging of tissue in its native state.7- 10 A confocal microscope differs from a conventional light microscope because it uses a point source of light, typically a laser, to illuminate a small spot that can be scanned within tissue. By spatially filtering the reflected laser light through a pinhole, an image is created from a thin plane of interest that is in focus. Light from tissue superficial or deep to the focal plane is rejected. In this manner, thin optical sections of biological specimens can be imaged by CRM at resolutions similar to those of conventional light microscopy.10
Several studies have demonstrated the use of CRM for imaging human and animal tissues in vivo.10- 12 To date, the most clinical utility has been demonstrated in ophthalmology, where CRM has been used to image the retina and cornea.13- 15 Confocal reflectance microscopy has also shown clinical potential in dermatology,16,17 where the skin is easily accessible for imaging. It has been used in vivo to monitor response of the skin to laser therapy16 and to define the margins of basal cell cancer during Mohs surgery.17 Confocal reflectance microscopy has also been reported by our laboratory as a potential in vivo screening tool for the early malignant conversion of oral precancer18 and to evaluate benign tumors of the parathyroid.19
In the present article, we describe CRM as a technique for rapid observation of surgically excised, fresh, unfixed, and unstained tissue. A confocal microscope built in our laboratory was used to image normal tissues of the head and neck. Confocal images were compared with corresponding standard histologic sections of the same tissues. The goals of our study were to (1) determine if CRM imaging could resolve the architectural and cellular morphologic patterns normally observed by routine histologic analysis and (2) increase our understanding of the interpretation and analysis of confocal images. This preliminary study on normal tissues serves as the foundation for studying pathologic tissues of the head and neck.
Tissue specimens from the head and neck were obtained under a Massachusetts General Hospital protocol approved by the institutional review board for handling of pathologic tissue. Tissue specimens included (1) 3 mandibular bone specimens; (2) 3 skeletal muscle specimens from the floor of the mouth; (3) 5 auriculotemporal nerve specimens; (4) 5 parotid gland specimens; (5) 7 thyroid gland specimens; and (6) 4 pieces of nasal mucosa. Freshly excised tissues were transported immediately to the pathology lab. After adequate frozen sections had been obtained, the remaining tissue was imaged en bloc by CRM. Thus, our confocal imaging did not disrupt the work flow of the surgical pathology laboratory. After imaging, the tissue specimens were submitted for paraffin embedding and permanent-section hematoxylin-eosin staining. Peripheral nerve specimens were processed with Bodian stain specific for myelin.
Details of the optical design of the confocal microscope and images of normal human skin10 and oral mucosa18 have been published previously. A near-infrared illumination wavelength of 1064 nm from a neodymium:YAG laser (model CV4; Santa Fe Laser Company, Tucson, Ariz) was used at 30 mW of power at the level of the tissue. A ×30, 0.9–numerical aperture water immersion objective lens provided a measured lateral resolution of 1 mm and a virtual tissue section thickness (axial resolution) of 4 mm.10 The lateral resolution is the nearest distance between 2 neighboring points or features that can be resolved in the image, and the axial resolution defines the optical section thickness of tissue from which light is detected at any given time. The axial resolution compared favorably with the thickness (typically 5 mm) of paraffin-embedded sections in standard histologic analysis. A tissue holder was developed to secure surgical specimens during imaging and limit the relative motion between the tissue and the objective lens.
Confocal images displayed on a video monitor showed the tissue in the horizontal plane, parallel to the tissue surface. The images were videotaped at 30 frames per second and then digitized using an 8-bit capture board (Pixelpipeline; Perceptics Corporation, Knoxville, Tenn) and image acquisition software on a Macintosh Quadra 840 AV (Apple Computer Inc, Cupertino, Calif). The images were enhanced, primarily to remove electronic noise imparted by videotaping, by scaling with bilinear interpolation, linear filtering, and contrast adjustment (IP Lab Spectrum, version 3.1; Scanalytics Inc, Fairfax, Va). After enhancement, confocal images were qualitatively correlated with companion routine paraffin sections stained with hematoxylin-eosin.
Confocal images of surgically excised tissue were acquired along with their corresponding permanent hematoxylin-eosin–stained sections. The confocal images were obtained to a depth of up to 400 µm on intact surgical specimens immediately after excision.
Confocal images of bone showed several structures characteristic of Haversian systems. In Figure 1A, a "bulls-eye" structure is seen in the right half of the image surrounding a central bright cylinder. The central bright structure (labeled "V") is a blood vessel; erythrocytes were seen within the cylinder when the imaging was performed in real time. Encircling this structure were multiple, thin, bright layers that corresponded to the concentric bone lamellae in the histologic preparation (Figure 1B). Several bright star-shaped structures were seen surrounding the central vessel. These corresponded to the nuclei of osteocytes contained within lacunae (Figure 1B).
Comparison images of normal bone. A, The confocal image shows a Haversian system containing a central canal with surrounding concentric lamellae (L). The multiple bright spots are osteocytes (arrows) contained within lacunae. A Volkman canal (V) is seen piercing the Haversian canal at a right angle (objective lens ×30). B, In the conventional histologic image, a Haversian canal (C) is seen in the center. Densely stained osteocytes (arrows) are seen as well as multiple empty lacunae. Concentric lamellae (L) are seen encircling the Haversian canal (hematoxylin-eosin, objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
The confocal image of skeletal muscle (Figure 2A) showed elongated gray bands against a black background. In some areas, elliptical dark structures with central bright dots could be seen wedging between the bands. These structures correspond to the basophilic peripheral nuclei of the skeletal muscle fibers in the histologic section (Figure 2B). Dark lines could be seen at fairly regular intervals running perpendicularly across the gray bands in the confocal image (Figure 2A). The diameter of the muscle fibers was approximately 50 mm in the confocal image, which correlated well with the histologic preparation.
Comparison images of normal skeletal muscle. A, In the confocal image, fibers are seen as parallel, horizontal, gray bands with peripheral bright nuclei (N) and dark transverse striations (arrows) (objective lens ×30). B, In the conventional histologic image, several skeletal muscle fibers show peripheral nuclei (N). Multiple transverse striations (arrows) are also seen (hematoxylin-eosin, objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
The nerve appeared in the confocal image as a dark tubular structure that contained alternating bright and dark bands (Figure 3A). Axons appeared as dark structures between 2 surrounding layers of bright myelin. In the histologic section of a peripheral nerve stained with Bodian stain specific for myelin (Figure 3B), fascicles of myelinated nerve fibers in longitudinal section were seen surrounded by connective tissue stroma. The epineurium, composed of loose connective tissue, could also be seen as a dark layer surrounding the nerve in the confocal image.
Comparison images of a normal peripheral nerve. A, In the confocal image, the most striking feature is the pattern of alternating bright and dark bands. The bright band is myelin (arrows), which scatters light much greater than the dark axons in between. The collagenous connective tissue sheath, the epineurium (E), surrounds the nerve (objective lens ×30). B, In the conventional histologic image, the myelin appears dark gray under Bodian stain (arrows). The axons are seen between 2 myelin layers, and the collagenous connective tissue sheath, the epineurium (E), surrounds the nerve (objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
Confocal images of the parotid gland sample (Figure 4A) appeared to be predominately composed of gray round structures separated by dark winding bands. The round structures correspond to the secretory alveoli, consisting of serous cells arranged around a central small lumen, which was barely visible, and striated ducts (Figure 4B). The dark background in the confocal image corresponds to the connective tissue septae that divide each lobule. Several large, bright polygonal cells could be seen interspersed within the gland, which correlated to fat cells in the histologic section (Figure 4B).
Comparison images of normal parotid gland tissue. A, The confocal image reveals several lobules of secretory alveoli (a) consisting of serous cells arranged around a central small lumen, which is barely visible, and striated ducts (D). Each lobule and alveolus is separated by connective tissue septae containing several intralobular adipocytes (F) (objective lens ×30). B, The conventional histologic image shows mostly strongly stained multiple serous acini (a). The clear hollow cells are adipocytes (F) that are interspersed within the parotid lobules. Centrally, a single striated duct (D) is seen (hematoxylin-eosin, objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
The confocal image of normal thyroid tissue (Figure 5A) revealed multiple dark round structures encircled by tightly spaced bright dots. When the optical section was moved through the intact tissue, it became apparent that these structures were spherical. These spherical structures correspond to thyroid follicles containing colloid, and the surrounding bright dots represent nuclei of the follicular cells. Interfollicular connective tissue was barely visible, and parafollicular C cells of the thyroid were also difficult to distinguish. In the histologic section, follicles of varying sizes were lined by flattened follicular cells and colloid with focal dense areas, which correspond to inspissated colloid (Figure 5B).
Comparison images of normal thyroid tissue. A, The confocal image shows multiple follicles of varying sizes lined by bright follicular cells (short arrows) and filled with dark colloid (C). There is scant interfollicular connective tissue. Inspissated colloid (long arrow) is also visible with confocal microscopy (objective lens ×30). B, The conventional histologic image shows that the thyroid follicles are lined with a simple cuboidal epithelium (short arrows) or follicular cells. The follicles contain a homogeneous material called colloid (C). Within the colloid, inspissated colloid (long arrow) can be seen, which occurs commonly with aging (hematoxylin-eosin, objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
The confocal images of nasal mucosa (Figure 6) showed a pseudostratified columnar ciliated epithelium containing columnar cells, goblet cells, and basal cells. Figure 6A shows a vertical section similar to a standard histologic study (Figure 6B) because the excised mucosal tissue was folded 90° from its surface and placed in contact with the objective. The cilia, as well as the basal bodies (centrioles) from which they arose, appeared bright. Interestingly, when imaging was performed in real time on the excised en bloc tissue, active ciliary motion was observed. Focally, goblet cells were identified between columnar cells by the presence of mucin in each, which appeared as individualized, round, and well-circumscribed bright structures. The nuclei of the basal and columnar cells appeared gray. Scattered, small, bright round cells, which appeared morphologically to be lymphocytes, were seen percolating through the epithelium. The lamina propria consisted of gray connective tissue, fibroblasts with bright nuclei, and blood vessels.
Comparison images of normal nasal mucosa. A, The confocal image shows a pseudostratified columnar ciliated epithelium containing columnar cells, goblet cells, and basal cells resting on a basement membrane. The cilia (long arrow) appear bright, as do the basal bodies (centrioles) from which they arise. A sharp distinction is apparent between the epithelium (e) and the submucosa (sm) containing serous glands (s). Focally, goblet cells are identified between columnar cells by the presence of mucin, which appears as individualized, round, and well-circumscribed bright structures. Scattered small bright round lymphocytes (short arrow) are seen in the submucosa (objective lens ×30). B, In the conventional histologic image, the nasal mucosa appears as ciliated, pseudostratified columnar epithelium (e). Within the epithelium are numerous interspersed goblet cells. The epithelium rests on a prominent basement membrane, and the underlying submucosa (sm) contains many serous (s) and mucous glands. Overlying the epithelium are numerous cilia (long arrow) (hematoxylin-eosin, objective lens ×40). The white scale bar in panel A and the bracketed scale bar in panel B indicate 100 µm.
In this study, we investigated the use of CRM as an alternative to conventional histologic analysis to noninvasively visualize and distinguish several different tissues. For each specimen, characteristic histologic features of various tissues and cell types were readily discernible by CRM and correlated well with routine histologic findings.20 In most tissues, there was less histologic and cytologic detail in the confocal images than was seen in the histologic sections. Some microscopic structures were more easily visualized with CRM than with histologic analysis, such as transverse striations in skeletal muscle (Figure 2A) and adipose cells in the parotid gland (Figure 4A); others were more difficult to visualize with CRM, such as the parafollicular cells of the thyroid (Figure 5A).
Variation in brightness of structures imaged by CRM is a function of the light-scattering properties of the tissues. Image contrast is due to local natural variations in refractive indices of various tissue substructures.8 Lipids, such as the phospholipids making up myelin,10 have a high refractive index and scatter light, making the myelin appear as bright layers surrounding dark axons in the confocal image (Figure 3A). Similarly, the cytoplasm of fat cells (Figure 4A) in the parotid gland appears bright owing to the high lipid content. Structures with similar refractive indices appear dark, such as the homogeneous colloid substance of the thyroid follicle (Figure 5A), which is composed of a glycoprotein complex called thyroglobulin.20 Axons in a peripheral myelinated nerve (Figure 3A), which are composed of numerous neurofilaments, microtubules, and mitochondria, also appear dark relative to their myelin sheath.20 An in-depth understanding of the factors that contribute to image contrast (ie, tissue optics) is still lacking, and these factors will need to be investigated further.
One potential advantage of CRM is the elimination of the drawbacks associated with tissue processing. For example, assessing the adequacy of tumor removal during a composite resection of the oral cavity is limited by the ability to evaluate bone margins.21 Bone is usually not evaluated by frozen-section analysis since the calcified tissue cannot be sectioned with a microtome. Pathologic evaluation of bone requires that it first be decalcified, which can take days, and so this procedure is not practical for intraoperative use. With CRM, rapid imaging of bone is possible without processing (Figure 1A), albeit at a limited depth, and may be used to provide immediate feedback to the surgeon. To view the lipid substance of tissues in frozen section, special staining procedures must be used (eg, oil red O), and paraffin-embedded tissue cannot be stained for fat, since the fixative solvent removes it. With CRM, the parotid gland can be imaged without dissolution of lipid (Figure 4A). Other artifacts in frozen-section analysis include enlargement of cells due to the freezing process, shrinkage (causing empty spaces or separation of tissue layers), distortion during excision, folds or wrinkles, uneven staining, precipitate particles, and degeneration of cells structure including shrinkage of nucleoli.4
However, confocal imaging may introduce its own artifacts, which are primarily optical effects and are not related to tissue processing or alteration. Optical artifacts may include (1) bright or dark spherical disks on the tissue surface due to bubbles or dirt in the immersion medium; (2) bright dots in the center of nuclei due to back-reflection of the illuminating cone of light from the underlying spherical nuclear membrane; and (3) interference fringes or "aliasing effects" from closely spaced structures within the tissues.8
Additional challenges to confocal imaging remain. Imaging with CRM can be performed to approximately a depth of half a millimeter, which limits imaging of invasive tumors en bloc or in vivo. However, the surgical margin is available at the surface of either resected tissue samples or in the surgical field. Also, this depth of imaging is more than adequate to quickly scan tissue sectioned for frozen analysis prior to embedding to ensure proper sampling of the lesion. Confocal reflectance microscopy does not involve the use of stains, but scattering agents may be useful to increase contrast and highlight structures in the tissues.22 Confocal images may be difficult for the untrained clinician to interpret, similar to ultrasound images, and additional training may be required. In the present study, only normal tissues were imaged with CRM. Studies should be performed to characterize different tumors in the head and neck by CRM and to determine how and to what extent disease alters tissue optics.
Since confocal imaging can easily be performed in vivo or on fresh surgically excised tissues (ex vivo), there are numerous potential applications for CRM as an intraoperative imaging tool or as an adjunct to standard surgical tissue histopathologic analysis. Intraoperatively, a large area of tissue could be scanned in a time-efficient manner with CRM, possibly improving the accuracy of margin selection and also increasing the chance of identifying tumor "skip areas." Identifying the surgical margin in vivo could provide quick feedback to the surgeon and decrease the need for multiple frozen sections. Confocal reflectance microscopy may also be useful for tissue identification and differentiation intraoperatively. For example, live confocal imaging of blood flow in the oral mucosa is striking,18 and vessels can easily be distinguished from nerves in the lamina propria.
Confocal reflectance microscopy could also provide a means of examining tissue specimens prior to cutting for frozen-section analysis, possibly to quickly differentiate mucosa from submucosa to ensure that a specimen is properly embedded—a judgment often difficult to make with the unaided eye. Studies have shown that a large number of errors in frozen-section analysis are due selection of nonrepresentative tissue (ie, sampling error).3,4 Obtaining multiple frozen sections has been suggested5 as a way to reduce errors in sampling, but this further prolongs the surgical procedure and increases the cost incurred by the patient.
It is unlikely that confocal imaging will replace frozen-section analysis, but its ability to image patients in vivo or excised tissues without histologic processing makes CRM useful. It probably has the greatest potential as an adjunct to frozen-section analysis, providing an additional armamentarium to the pathologist and surgeon for intraoperative consultation. This new imaging technique, if proven effective, may in some instances reduce the need for multiple frozen sections, thereby decreasing the "wait time" for the surgeon, total operative time, cost, and the risk of morbidity to the patient.
In conclusion, the present work demonstrates that intact, fresh surgical tissue can be rapidly imaged by CRM with high resolution and contrast such that microscopic anatomy can be delineated. Confocal images of freshly excised surgical specimens were compared with paraffin-embedded, hematoxylin-eosin–stained sections. We were able to distinguish the histologic characteristics of various tissue types with CRM and document good correlation between CRM and conventional histologic analysis. An in-depth correlation of confocal images to standard histopathologic findings of both normal and diseased tissue is essential to further validate this diagnostic imaging modality.
Correspondence: Richard L. Fabian, MD, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (firstname.lastname@example.com).
Submitted for publication September 5, 2003; accepted November 19, 2003.
Funding for this project was provided by Lucid Inc, Henrietta, NY.
A portion of this work was presented as a poster at the Annual Meeting of the American Academy of Otolaryngology–Head and Neck Surgery Foundation Inc; September 26-29, 1998; San Antonio, Tex.
We thank Steven D. Rauch, MD, and Joseph B. Nadol, Jr, MD, for their critical reviews of this manuscript.
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State police hunting for mailbox smashers
GIRARD -- State police are on the hunt for vandals who smashed numerous mailboxes in western Erie County and taunted police during their exploits over the weekend.
Police said they had taken at least a dozen reports Monday morning from victims of mailbox smashings in Elk Creek, Fairview, Franklin and Girard townships. A note signed by "The Mailboxers" was found at one of the scenes and challenged police to catch them, police said.
Anyone with information is asked to call state police in Girard at 774-9611.


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Doctor insights on:
Bloody Nose
Bloody Nose (Overview)
Bloody nose may be caused by bleeding within the nostrils, or from problems further back in the nasal airways.
Can nose sprays cause bloody nose?
Yes: They can irritate the tissue and steroid sprays can thin the nasal lining. Both cases result in increased risk of bloody nose. ...Read moreSee 2 more doctor answers
Bloody Nose (Overview)
Bloody nose may be caused by bleeding within the nostrils, or from problems further back in the nasal airways.
What does it mean when you get bloody nose and headache at the same time?
Another thought...: IF you are using nasal sprays with steroids, headaches, sore throat and nosebleeds are common side effects when used improperly. ...Read moreSee 1 more doctor answer
Treating a Nose Bleed (Checklist)
What's the best way to treat a bloody nose?
Hold on tightly: Sit up, lean forward and put your chin on your chest. Grab the fleshy part of your nose and pinch the fleshy part against your face between your thumb and forefinger (like a clothespin). Squeeze tightly for 15 minutes and this should stop most bleeds. Do not blow your nose after this maneuver or you will blow the clot off and it will bleed again. If the bleeding doesn't stop see an md. ...Read moreSee 2 more doctor answers
What can I do if my breathing treatment for asthma caused me to get a bloody nose is this normal?
Not common: Some people taking albuterol may experience side effects such as a sore or dry throat, this dryness may lead to nose bleed. ...Read more
How do you get rid of a bloody nose correctly?
Pinch the nose: Pinch the nose till the bleeding stops. Here is a video with more info for you http://www.Youtube.Com/watch?V=dp_i-gja7ui. ...Read moreSee 1 more doctor answer
When I was just kid I had bloody nose, now I am 21 still have bloody nose, how do I prevent it? Sometimes won't stop for 2-5min(iam firstaid certified
Nose bleeds: The best way to prevent nose bleeds in your situation is to keep the nose moist. You can try nasal saline spray and saline based gel that can be applied gently with a qtip 2-3 time a day depending on the humidity.If you sleep in a dry environment get a humidifier. If the symptoms persist or accompanied by nasal obstruction, visit an ENT for evaluation. Cauterizaiton of a blood vessel maybe needed. ...Read moreSee 2 more doctor answers
My son gets bloody noses very bad. Recently he has told me when he gets a bloody nose, it heart hurts. Should i be concerned?
See physician: Need checked, may be allergies but could be blood clotting problem, which there are several. ...Read more
I get bloody nose a lot. What does this mean? Is something wrong with my nose?
Maybe: Frequent nose bleeds are not common. If you are taking Aspirin or Ibuprofen type products frequently, this may affect how your platlets adhere to each other and may increase your risk of nasal bleeding. You may also have a deviated septum - the middle part of the nose. Frequent nose bleeds should be evaluated. See your local ent. ...Read moreSee 1 more doctor answer
My baby got a huge bloody nose, a lady gave tissues&helped, then i saw she has fresh blood on her nail, if it's her blood, any HIV risk to my baby since my baby and the lady were both actively bleeding.
Unlikely: The statistical probability is staggeringly low, worry about your child being struck by a meteor instead. The blood on her nail my have been from trying to help your baby. ...Read moreSee 1 more doctor answer
Nosebleeds (Definition)
Nosebleeds is also known as Nose bleeds. A nosebleed is a symptom in which there is enough bleeding in the nose for a person to see it coming out of the nose or taste it going down the throat. Nosebleeds are often due to a broken small blood vessel, and stop when a clot forms at the break ...Read more
Nasal (Definition)
NaSal is a nasal preparation which is a kind of ...Read more
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on June 1, 2013 - 11:52 PM
, updated June 1, 2013 at 11:53 PM
Canisius wasn't done any favors
Upon examining the College World Series schedule, I would have to conclude that Canisius was given a bum deal. Canisius opened with North Carolina, one of the top five teams in the country. Of the 64 teams scheduled, there are only 10 teams with records better than Canisius. While the Canisius schedule is probably weaker than many of the big name conferences, nevertheless, there are many other small conferences whose teams got more favorable draws.
Teams like Towson, Elon, San Diego State, and Bowling Green all got to play teams ranked far lower than North Carolina. Canisius should have gotten a more favorable draw with a 42-15 record going into the tournament.
Don Weimer
Penalty shot call was the right one
I am tired of every sportscaster and commentator complaining that the rules of hockey are not enforced and when they are, they complain that the refs are affecting the game. You can't have it both ways.
In the recent Game Six of the Detroit-Chicago series a penalty shot was called when the Red Wing defenseman tried to separate the hands of Blackhawks forward Michael Frolik from his arms because he clearly had a breakaway on Detroit goalie Jimmy Howard. Sorry sports fans, the ref was right.
The real tragedy of the events was that the way Howard has been playing he would have stopped that shot. Instead he had to contend with a very good player in Frolik who had all the time in the world to place his shot instead of having a defenseman on his backside. The Detroit defenseman made two mistakes; he got beat and then took a dumb panic penalty. He was the one who affected the game.
Rick Kotecki
Marathon gives much bang for buck
Hats off to the organizers of the Buffalo Marathon. For the low price of $45, which is more than half the cost of marathons in other cities, I received two shirts, a massage, a pre- and post-race party along with a flat and scenic course lined with friendly spectators and volunteers, and first-rate entertainment.
I can't see any reason anyone would go out of town to do a marathon when we have the best right here on our own backyard.
Marty Farrell
West Seneca
Big moves could make Sabres a better team
So, Darcy Regier and Ron Rolston are here to stay and the Sabres are rebuilding. OK. But, not only doesn't that have to take forever, it's possible to win and rebuild at the same time. That however will take a level of aggression for which Regier is not known. To help him out, here are some moves the Sabres can make to both stabilize the 2013-14 roster and prepare the team for success in the future.
The first: send Stafford, prospects Larsson and McNabb, a first round pick (No. 16) and a third round pick to Anaheim for Bobby Ryan. The Sabres need to replace Pominville's goal production, and a line of Vanek, Grigorenko, and Ryan could produce nicely.
The second: ship Gerbe, goalie prospect Hackett, and a second round pick to L.A. for the rights to goalie Jonathon Bernier. Bernier's sure to be a hot restricted free agent this off-season, and a fair talent/prospect/pick package should be able to pry him loose.
Lastly, the big trade, and this may be the suffering Darcy referred to as it's expensive and involves fan favorites, but the payoff is undeniable. Trade Miller, Myers, Ennis, and our first first-round pick (No. 8) to Colorado for Paul Stastny and the first overall pick in this year's draft. The Sabres need a veteran third-line center like Stastny, who has offensive and defensive skills. The real prize, however, is the pick, which the Sabres should use on phenom center Nathan MacKinnon. McKinnon is the elite type of player not seen here since Pat LaFontaine, and he's worth moving heaven and earth to acquire.
These moves are complicated, but very doable. Add to them the buyout of Leino and the signing of Cup-winning free agents Andrew Ference and Craig Adams, and the Sabres can compete and rebuild simultaneously. Here's hoping.
Marc Rummenie
East Aurora
Kudos to Thomas for Oklahoma help
Thurman Thomas' effort in helping the storm victims of Oklahoma is very heartfelt and he should be applauded. He was commendable in his effort to help the victims of this tragic storm.
This Hall of Fame great made a Hall of Fame gesture and was a touchdown in the hearts of the people who lost so much during this devastating storm.
John Jendrysek
Orchard Park
Stevie needs work to be a team leader
Jerry Sullivan's column on Stevie Johnson stepping up to be a leader and mentor for the younger players was certainly a head-turner.
Stevie seems more interested in stats and tweets than being a role model. Younger players have to look up to someone who is mature and dependable. Not blaming everyone but himself for his failures. The Bills are going to be a team with potential, like another professional team in Buffalo.
The diehard fans have got to be wishing and hoping. So let' wish and hope.
Paul DiVito
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DC Council Opening Statements: Wizards vs Pistons, Game 56
Here to provide the DC Council Opening Statements for Washington's 56th game of the season at home against the Detroit Pistons are TAI's Rashad Mobley (@rashad20) and guest Dan Feldman (@PistonPowered) who writes about the Pistons for PistonPowered an ESPN TrueHoop Network blog. Dan also does freelance work for the Associated Press.
Wizards Starters (18-37):
John Wall, Bradley Beal, Martell Webster,
Nene, Trevor Booker, Emeka Okafor
[Nene is out with a sore shoulder.]
Pistons Starters (22-37):
Jose Calderon, Rodney Stuckey, Kyle Singler, Jason Maxiell, Greg Monroe
Q #1: What have you done for me lately?
(What's the status of the Pistons over the past week?)
@PistonPowered: In the last week, the Pistons have beaten the Bobcats (the Bobcats!), lost by 32, lost by 18 and lost by 11. Detroit has struggled amid several issues — injury (Andre Drummond and Brandon Knight), suspension (Will Bynum) and youth (Kim English, Khris Middleton and Viacheslav Kravtsov). Bynum should return tonight, and Knight might, too. That might mean the Pistons rely less on the aforementioned three rookies, who've been more miss than hit when pressing into larger roles.
Q #2: Who threw out my alarm clock?
(Which player(s) are we sleeping on?)
@PistonPowered: Andre Drummond. If it weren't for Lawrence Frank limiting his role, Drummond might Rookie of the Year favorite right now. Drummond, with an ability to create dunks and block shots, has developed more quickly than nearly anyone expected. Unfortunately, Drummond is out injured, so feel free to return to your slumber. I just wanted to mention how well he's playing, because I'm not sure that's been appreciated enough nationally.
Q #3: What game-within-the-game counts most?
(What matchup between two players or between each team in a particular statistical category is most important.)
@PistonPowered: John Wall-Greg Monroe. Wall swore revenge for this, and he's 0-3 in games against Monroe since. Does he still care? I sure hope so. One was the No. 1 pick in the 2010 draft, and the other has been, to date, the top player in the 2010 draft. Bragging rights are definitely on the line. [Ed. Note: Paul George, also drafted in 2010, isn't too shabby — he's the first All-Star from that draft class.]
Q #4: How it's going down?
(TAI's general key to the game.)
@rashad20: During their pregame pressers tonight, both Randy Wittman and Lawrence Frank stressed the importance of stopping the opposing team's point guard. Coach Frank discussed how much better the Wizards have played in transition since Wall arrived (he even made reference to the Wizards' deadly corner 3-point shooting), and he stressed how important it is for the Pistons to slow him down. Coach Wittman mentioned that the last time the Wizards played the Pistons (back on February 13th, the last game before the All-Star break), Jose Calderon had his way with his team. Wall had 16 points and nine assists in the last matchup, but Calderon outplayed him 24 points–14 of those points coming the second half. Both players are good enough to get the best of the other on any given possession, but the player who is effective down the stretch will be the one who drives the opposing coach crazy.
The Spread: The Wizards are 6.5 point favorites over the Pistons; the over/under is 190.5 points (via USA Today).
@PistonPowered: Pistons 97, Wizards 92. The Pistons see a game like this on their schedule, and they play harder. They know this is an opportunity to snap their three-game losing streak and even pad their stats a little. That's not necessarily the DNA of a championship team, but it seems to be the DNA of these Pistons.
@rashad20: Pistons 99, Wizards 86. The Wizards are playing well as of late, but the Pistons have won all three of their matchups against them for a reason. The game will be close, and then Rodney Stuckey or Will Bynum will provoke a "backbreaker" out of Steve Buckhantz.
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- Shredded by Schröder — Wizards vs Hawks, DC Council 71 March 24, 2016
- Opening Statements: Wizards vs Hawks, Game 71 March 23, 2016
- From The Other Side: Catching Up With Kevin Seraphin March 23, 2016
- Big Panda Brings the Chill to Hotlanta — Wizards at Hawks, DC Council 70 March 22, 2016
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Nelson Mandela would probably have appreciated it. There was peace and reconciliation, and a gospel choir from Soweto that did its best to sing the roof of Westminster Abbey off — and, just in case anyone got carried away by the forgiveness of sins past, the occasional sharp reminder about who was on the right side of the anti-apartheid struggle back when it really counted.
The memorial service at Westminster Abbey yesterday, at which Prince Harry represented the Queen, brought politicians of every persuasion together with former activists to honour the life of the former South African President — from David Cameron,


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text: NOW SOLD OUT: On Sunday the 9th of October 2016 I will be teaching a open seminar on kata bunkai / practical karate in Swansea! The seminar will run from 11am to 3pm and will cost just £25 per person. The location of the seminar is Ystradgynlais Sports Centre, Glanrhyd, Ystradgynlais, Swansea, SA9 1AP.


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Added by NiagaraFallsHotel Subscribe 1
Published 2 Dec 2009
CrownePlazaNiagaraFallsHotel.com or (800) 263-7135 CROWNE PLAZA NIAGARA FALLS - FALLSVIEW The Crowne Pla...
CrownePlazaNiagaraFallsHotel.com or (800) 263-7135 CROWNE PLAZA NIAGARA FALLS - FALLSVIEW The Crowne Plaza Niagara Falls-Fallsview is famous for combining traditional charm and modern amenities to create a memorable guest experience in Niagara Falls. Enjoy traditional service, comfortable overstuffed beds, the historic lobby and Fallsview dining at the Fallsview Rainbow Room Restaurant. The Crowne Plaza offers fallsview guestrooms and suites to make the most of its location, directly across from the Falls. The landmark Crowne Plaza Hotel is the perfect choice for a great romantic Niagara getaway or a family vacation. Direct indoor connections to the Falls Avenue Entertainment Complex including the Fallsview Indoor Waterpark make the CrownePlaza a one stop vacation destination. SHERATON ON THE FALLS The Sheraton on the Falls Hotel, with 670 beautifully appointed guest rooms is Niagaras 4-Diamond family resort. The hotel offers the guaranteed best Fallsviews from its spectacular Fallsview rooms and suites that feature floor to ceiling custom glass windows as well as balconies. For a memorable fallsview meal try the Fallsview Restaurants 80 foot buffet for breakfast, lunch and dinner. Be sure to visit the two swimming pools, the Christienne Spa and Fitness centre for a relaxing and pampering time in Niagara Falls. During the summer months watch the fireworks over the Falls from your private balcony and enjoy the year round indoor connections to more than 50 attractions including Adventure City, the Rainforest Cafe, Hard Rock Cafe, the Fallsview Indoor Waterpark and Casino Niagara. SKYLINE INN The recently renovated Skyline Inn offers guestrooms with refrigerators and coffee makers, in a location that unbeatable! Located just steps from more than 50 attractions and the Falls, the Skyline Inn offers enclosed tropical garden courtyards that feature family movie nights throughout the week, spacious rooms, on-site Perkins Restaurant and a climate controlled Skywalk that provides direct access to the Fallsview Indoor Waterpark. The Skyline Inn has quickly become a family favourite. Recently renovated Deluxe Family Bunk Bed Suites that have a separate bunk bed sleeping area for the kids. HAMPTON INN BY HILTON AT THE FALLS The Hampton Inn by Hilton At the Falls is a family-fun hotel with a seven-storey atrium, indoor pool, whirlpool and more. The fabulous family themed suites are a hit with visitors, especially with the added bonus complimentary services including free parking, in-room movies, 100% smoke free facility, internet, and the complimentary hot on the house breakfast buffet each morning. The ideal location of the hotel, directly across from the Fallsview Indoor Waterpark, Casino Niagara provides easy access to all of Niagaras top attractions including Clifton Hill. Falls Avenue has guestrooms spanning the spectrum: high-end high-rise with spectacular fallsview, charm and grace at Niagaras historic hotel or family comfort and affordability at either the Skyline Inn or the Hampton Inn by Hilton At the Falls. Everyone will feel right at home on Falls Avenue. Check out the Falls Avenue Hotels website at NiagaraFallsHotels.com for fabulous getaway packages. When you book direct you are guaranteed the lowest hotel rate or you stay FREE!


text: › Academics » Music » Current Students Home Prospective Students Majors and Degrees Auditions Request more information Visit Us Scholarships and Aid Alumni Success Graduate Schools Student Profiles Our Ensembles Program Overview Majors and Degrees Auditions Course Descriptions Ensembles Master Classes Study Away Meet Our Faculty Concerts and Events Music Event Calendar Featured Events - Sound Quality & More Purchase Tickets Pre-College & Adult Programs Fall Choral Festival Single Reed Day Band Senior Visit Day Piano for Young People Church Music Conference Facilities Daniel Recital Hall Nan Trammell Herring Music Pavilion McAlister Auditorium Daniel Chapel Lakeside Amphitheater Multimedia Current Students Placement Auditions Musician Health and Safety Marching Band Application Choral Application Concert Band Application Jazz Application SAI Reception Request Contact Music Tell Us About You Plan a Visit ›Apply Now ›Give to Furman › Main Content Column 1 Placement AUDITIONS Fall 2016 Placement Information and Excerpt Links Recital Forms and Check Lists Recital program preparation and printing is coordinated by Administrative Assistant Ms. Emily Sweezey in DMB-103, 864-294-2176. GUIDELINES: See Music Handbook, Article 22 STUDENT RECITALS as well as the Recital Guildelines for your specific major. Tuesday afternoon Recital Application Recital Check List Jr Sr Recital Jury Application Recording Services Agreement Program Samples WEB FORM: Submit a Reception Request to S.A.I Musician Health and Safety: Read more Academic information Questions? Talk with your faculty advisor or the chairman's administrative assistant, Emily Sweezey, in office DMB-103, 864-294-2176. Music Department Handbook 2015-2016.pdf Music Major Preliminary Approval form.pdfYou complete this form sophomore year and turn into the music office. The faculty will then discuss and vote to approve/not approve your B.M. music major request. Registrar's Major Declaration Form and Music Major ChecklistThis final declaration form is normally completed by Emily Sweezey AFTER the faculty vote to approve your preliminary request. Furman Handbook: Music Academic Course Descriptions Jury Repertoire FormS Keyboard String Voice Wind/percussion Music in Italy Study away program information Italy Application for Fall 2016 Student-Run Organizations Professional Music Fraternities: The Sisters of Sigma Alpha IotaThe Brothers of Phi Mu Alpha Bell Tower Boys male vocal ensemble Furman Belles female vocal ensemble Pauper Players Gospel Ensemble


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Bye, Bye Miss American Pie
February 2, 1959, was the end of an era; a tragic night that saw three of the most promising musicians American popular music had ever known dead in a plane crash in a remote field near Clear Lake, Iowa. Buddy Holly, Ritchie Valens, the Big Bopper and the man who piloted their small aircraft all died that cold night. It was a blow that shocked a generation of music lovers, who were still sheltered from the turbulence that the 1960s would bring. Valens and the Big Bopper were great talents, to be sure, but Buddy Holly's loss was and still is particularly painful for many rock enthusiasts. Holly's music was the first that John Lennon tried to emulate and the bespectacled one was also idolized by Keith Richards. His influence is still widely heard in modern music, inspiring everyone from The Raveonettes to Weezer to REM. Obviously, the potential of any one of those three men will never be known, but their groundbreaking sounds didn't really go anywhere. The Night the Music Died (which is a bit of a misnomer if you think of it in terms of influence) is a great example of that. In this revue, you'll see Holly, Valens, and the Big Bopper's final performance reenacted down to the last detail. The trio hits the stage 2:30 p.m. Wednesday and 2:30 and 7:30 p.m. Thursday, May 27, at the Palace Theatre in Grapevine, 300 South Main. Tickets are $27, or $12.50 for children under 13. Visit texasfamilymusicals.com.
Wed., May 26, 2:30 p.m.; Thu., May 27, 2:30 & 7:30 p.m., 2010
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Strange, Odd, Weird or Wacky/* BEGIN: Block 2 of 2 Greg Add 2013 (Jan 29) */ ?> /* END: Block 2 of 2 Greg Add 2013 (Jan 29) */ ?>
Mein Kampf Manga Blitzes Bookstores With Comic Nazi-nessby Steve Levenstein
Prius 6-Door Limo Goes To Great Lengths For Hybrid Efficiencyby Steve Levenstein
Jailhouse Fire: Entrepreneurial Inmates Market Their Brand Of Hot Sauceby Beth Graddon-Hodgson
It's no secret that some inmates in prisons in North America have privileges; you don't even want to get me started on some of the opportunities available to Canadian prisoners who have more opportunities available to them than some law abiding citizens. Freedom might not be one of the privileges of a group of Floridian inmates, but that hasn't stopped them from developing entrepreneurial roots.
Stroke's Extra Leg: Leg Warmers Designed To Protect Your Pantsby Fashion Finds
The leg warmers of the 80's and the most recent decade where the style has made an appearance are designed more for fashion than function, although they do offer some level of warmth as promised by their name. Stroke's Extra Leg is similar in design, but it serves a very different purpose that is more about function than fashion.
Yucky Or Yummy? Deep-Fried Butter & More At The Texas State Fairby Toby
6 Best Ways To Use A Michael Vick Mask This Halloweenby Lady Bee
Is Smart Mass the Ultimate Adult Office Toy?by John P. Barker
Bunny Petting Cafe Has Rabbit Fans Hoppingby Steve Levenstein
Crocodile Foot Charm Means 'Hands Off'by Steve Levenstein
Propeller Island Hotel: Luxury Hotel With Strange And Freaky Themed Roomsby Beth Graddon-Hodgson
Propeller Island Hotel in Berlin, Germany is among the strangest and funkiest places to stay in the world. This certainly isn't your typical Motel 6; find out why at this cool hotel you'll have an experience you'll never forget.
Wall-E's Girl-friend's Cousin, Le Petit Prince, a Robotic Garden For Marsby Gloria Campos
World's Most Disgusting Restaurant? Modern Toilet Eatery In Taiwanby Beth Graddon-Hodgson
You've heard of someone having a potty mouth, right? Well at Taiwan's Modern Toilet restaurant you can almost take that statement literally based on their décor and plating methods.
Cardboard Tube Fighting to Be the Next Great Sportby Chris Weiss
Weird Voice Messenger Makes Me Reach For Fly Swatterby John P. Barker
Leggings are all the rage, not that I need to tell you that. But, typically they are a modest trend that lends a level of conservative fashion to what would otherwise be scandalously short dresses and bare legs. But not all leggings are modest; some actually make a sexy fashion statement of their own.


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We confess to smuggling out the arresting details, strong convictions, and guilty pleasures of these writings from prison. Fatos Lubonja recalls his chilling "Second Sentence." Fadhil al-Azzawi negotiates prison politics in "Cell Block Five." Khadija Marouazi's phobic captive rats out his innocent cellmate in "Biography of Ash," while Tirdad Zolghadr cuts a deal with his new "Friends." Jorge Garcia and Fidel Martinez's defiant women prisoners sing "The Ballad of Ventas Prison." Leena Lander's political activist in "The Order" writes her last letter to the foster father she served, then betrayed. Mario Benedetti reveals the captive unconscious in "He Dreamed That He Was in Prison." And in escapes from other forms of confinement, Guillermo Saavedra's "Runaway Country" captures a nation fleeing political and economic chaos, while Cuban exile and mental patient Guillermo Rosales "checks out" of his euphemistic "Boarding Home." We trust you'll be a captive audience.
Also in this Issue
from A Short History of Dance
Listen, child, to a wise old wolf: / in dance everything has its own meaning.
Other People
It was always the same. The express trains were drafty. They kept them too cold, and no matter how warm the jacket, it didn't help. Mareike knew this stretch, she could recite the stations in
The departure came in the month of March, when the thaw opened up the passes, which in our mountains were like gateways toward the countries of central Europe. They would go on foot, with the
Book Reviews
from Second Sentence
February 1979 started with heavy snow, a biting wind, and the baying of the Alsatian kept by the guards to foil escape attempts. Superstitious prisoners claimed that the dog's howling at night
from Cell Block Five
It took me some long months to realize that I was incarcerated. My dreams had suddenly ended. Like Zoroaster I awoke from a lengthy slumber to discover rudely and bitterly that justice does not
from Biography of Ash
There, where my body seemed to lay a great distance from me, I put my hand on my leg, on my fingers, and I couldn't tell they were mine. My thighs. My legs. My waist. Everything was dry and
A warden takes me by the arm as I slip on my blindfold and step out of the cell. I'm led down several corridors and seated down somewhere as a door swings shut behind me. I raise my head to
From The Order
Translator's Note: The story takes place in 1918 Finland, right after the end of the Finnish Civil War, where some 30,000 Finns were killed, most by summary execution or in detention camps.
He Dreamed That He Was in Prison
That prisoner dreamed that he was in prison. Naturally, the dreams had details and patterns. For example, on the wall of the dream there was a poster from Paris; on the real wall there was only a
Runaway Country
¡Argentina, Little green branch afire! -Ricardo E. Molinari LIGHT Fire? No: light. Flame? No: light. Light? Yes: this light. Light like this? No: like smoke


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Hilti Fastening Systems - Sioux City, IA - Phone: (712) 258-4583
Hitch & Buggy - Sioux City, IA - Phone: (712) 252-1660
Siouxland Trailer Sales Inc - Sioux City, IA - Phone: (712) 233-2930
Recreational vehicles are available for renting and leasing also. People, who are thinking of going for vacations, can easily take the help of the rental companies in Sioux City for renting recreational vehicles during their stay. The renting of the recreation vehicles is an affordable way to spend the vacation and have different types of experiences.
There are quite a number of rental companies in Sioux City which provide renting and leasing service of recreational vehicles. Renting recreational vehicles also help in keeping a check on the pollution level due to low emission of carbon- dioxide. In Sioux City, vacationers can enjoy their vacations with family and friends by availing the services of these renting and leasing companies of recreational vehicles.
NYS Comptroller Thomas DiNapoli Addresses Clean Energy Leadership Task Force
Audits Confirm Savings from Energy Efficiency Improvements at Long Island School Districts (Long Island, NY) On Friday, February 19th, New York State Comptroller Thomas DiNapoli spoke before the Clean Energy Leadership Task Force which is a project directed by the Sustainability Institute at Molloy College located at Republic Airport in Farmingdale NY. Mr. DiNapoli discussed the results of audits..


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Barassie Street, Troon KA10 6LU (view location map)
Tel: 01292 269793
Book and pay
The pool at Troon is 25m with 4 lanes. There is also a small teaching pool and a
spectator area for up to 35 people. Organised activities include Early Bird sessions,
aqua trim, power hour, pool discos and fun sessions, plus a full programme of swimming
instruction, competitive swimming and life saving.
A range of classes are on offer including Parent and Child (aged 6 months - 3 years),
Ducklings (aged 4 yrs old and not at school), Childrens (aged 5 or at school – 16 years) and Adult lessons. The lessons are a block of ten
half hour lessons for Parent and Child, Ducklings and Junior classes. The Adult Lessons are a block of ten 45 minute classes.
22 August 2016 - June 2017
Last admission 30 mins before closing.
* Please note: Jan-Easter General Swimming opens at 12pm. Early Birds closes at 9am.
Check to see if you are eligible for a
Leisure Card.
How to find the Troon swimming pool
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In honor of all of our amazing husbands out there and the quickly approaching Father's Day, we have decided to once again hold our {now annual} HOT HUBBY CONTEST!! It's simple, really! Just send in a picture of your husband and ONE sentence {in 20 words or less} explaining why he is the best spouse ever... and then get all of your friends and family to PIN his photo to their Pinterest Boards... spreading the word! EASY, right! Go grab a photo of your man and...Continue Reading
Hubby Highlights
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The Vegas Date
A Date Night in Vegas, Nevada!
Hit all the fun 'hot spots' in Vegas for date night with this fun and creative date night idea.
I am madly in love with this guy...and as you will see from the following post....it's pretty easy to stay that way! :) My husband, Jamie, never ceases to amaze me. He is the perfect gentleman and he always puts my needs above his own. I had SO much fun on this date he planned for us....but I will let HIM tell you all about it....Continue Reading
Check out more Hubby Highlights Ideas and Posts


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It's a cliche, but life really does slow down in the North Woods.
Long, tea-fueled chats around the kitchen table and meandering bike rides and ski workouts are staples of my visits to friends in Land O' Lakes.
Seeking even greater relaxation and solitude, my friend Phil and I took a day trip and canoed through the Sylvania Wilderness, part of Ottawa National Forest in Michigan's Upper Peninsula. Home of 34 named lakes and zero motors over 4 HP (only allowed on one lake), Sylvania epitomizes the concept of serenity.
Isolation looks inviting from the seat of a canoe. Photo by Sara Knutson.
Visitors typically begin trips from the entrance station just over the border in Michigan, but Phil lives on property that adjoins Sylvania, so we began at Big Bateau Lake, which just dips into Wisconsin.
The lakes are connected via blessedly short portages, and we easily traversed through six lakes without any portages long enough to require a rest break. We took turns hoisting the canoe on our shoulders, and marveled that Lewis and Clark traveled in the same way--without the benefit of Sylvania's well-marked paths.
Sometimes leisure requires labor. Photo by Sara Knutson.
Wildlife at Sylvania is plentiful.
An enormous bald eagle nest at Big Bateau revealed glimpses of both adult and juvenile birds. We found more sightings at larger Crooked Lake. We even saw one eagle swoop down toward a merganser and her chicks, unsuccessfully attempting to land a quick meal.
The biggest treat, however, was the pair of loons hunting on appropriately named Loon Lake. The fish-eating birds can swim underwater for up to 2 minutes, so we often watched them dive and then waited to see where they'd pop up again, sometimes 60 feet away or more.
We cautiously meandered toward the loons, hoping for a good view, and hit pay dirt. The loons popped up and down, often within 10 feet of the boat. Once, in truly unusual fashion, they actually swam directly under our canoe. They were likely 20 feet below the surface, but Loon Lake's crystal clear water allowed for a perfect view.
An eagle scouts for a meal. Photo by Sara Knutson.
Journeying from lake to lake lent a satisfying sense of accomplishment to the day, but we agreed that the 30 minutes spent just sitting in the boat, watching the life surrounding us and studying the loons' behavior was our favorite part of the trip.
Those who love a good hard day of paddle-and-portage won't be disappointed. There are big loops of lakes and abundant campsites on both the easily-accessed and more remote lakes, offering plenty of resources to pack even an intense multi-day trip.
But keep in mind--you're in the North Woods. Why rush?
Sara Knutson is a Shorewood native pursuing divinity studies at Boston College. In previous posts for Off the Couch she detailed her solo ultra-marathon on the Ice Age Trail and a fast from official racing.
Read and share your thoughts on this story.
For your convenience, the same email address and password can now be used to:


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Barrett to unveil custom-tailored job training plan
Jobs will be theme at Milwaukee mayor's 'state of the city' address
Seeking to address a gap between workers seeking jobs and companies seeking workers, a new program will custom-tailor job training to employers' needs, Milwaukee Mayor Tom Barrett says.
Barrett plans to unveil the program, called the Mayor's Manufacturing Partnership, during his "state of the city" address Monday.
Also Monday, Barrett will announce that Sigma-Aldrich Corp. is adding 40 jobs through a $30 million project to consolidate distribution operations at the chemical company's north side plant.
Jobs and economic development typically dominate Barrett's annual speech, which he usually delivers at a location chosen to highlight those themes. Monday's speech is set for 8:30 a.m. at the Menomonee Valley plant of Ingeteam, a Spanish-owned wind turbine manufacturer. Barrett announced Ingeteam's plans to build the plant during his 2010 address.
The emphasis of the manufacturing program is on collaboration, Barrett said.
Funded by $450,000 to $500,000 from the Milwaukee Area Workforce Investment Board, the program will start by asking manufacturers what skills they need, Barrett said. Then the workforce agency will help find about 500 workers - both job-seekers and current employees - for the program to train in those specific skills, he said.
The training will come from Milwaukee Area Technical College and the Wisconsin Regional Training Partnership/Big Step, as well as apprenticeships and possibly on-site training at the employers' plants, Barrett said.
Milwaukee Gear Co. has successfully used a similar approach to job training, said Barrett and Rick Fullington, chief executive officer of the Glendale-based manufacturing company.
Working with WRTP/Big Step and Waukesha County Technical College, Milwaukee Gear started a program to train students in the state-of-the-art field of computer-numerically controlled machining, Fullington said.
About a year ago, 15 students went through a 10-week training program that included weekly job-shadowing of Milwaukee Gear employees, Fullington said. All 15 completed the program and were hired by Milwaukee Gear within two weeks, he said.
"We had such success with it that we decided to do it again," Fullington said.
Another 15 students completed the program Feb. 3, and Milwaukee Gear has hired 13 of them, Fullington said. The two others were hired by another company.
The 13 new hires will push Milwaukee Gear's workforce past 250, meaning the training program has produced more than 10% of the company's employees.
"It's a good collaboration and a good approach, particularly for companies my size" that are too small to design and run their own training programs, Fullington said. "We're very pleased."


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'These children don't recognize the flags of their home countries, but they can all sing "Jesus Loves Me."'
Out of the mouths of babes...
New Jersey high school student Matthew LaClair has been at the center of controversy before, challenging his U.S. History teacher for proselytizing in class. He's in the news again, bringing attention to conservative bias in his American history textbook. [more inside]
Airline Faith
AA pilot asks for faith of his passengers. Air flight can be intimidating as it is - especially when your pilot has a nagging desire to introduce you to God.
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