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Most Cited Cardiovascular Pathology Articles
The most cited articles published since 2011, extracted from Scopus.
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosisMichael A. Gimbrone | Guillermo García-Cardeña
Volume 22, Issue 1, January 2013, Pages 9-15
The localization of atherosclerotic lesion formation to regions of disturbed blood flow associated with certain arterial geometries, in humans and experimental animals, suggests an important role for hemodynamic forces in the pathobiology of atherosclerosis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow, can discriminate among these different biomechanical stimuli and transduce them into genetic regulatory programs that modulate endothelial function. In this brief review, we discuss how biomechanical stimuli generated by blood flow can influence endothelial functional phenotypes, and explore the working hypothesis of atheroprone hemodynamic environments as local risk factors in atherogenesis. In addition, we consider the therapeutic implications of the activation of atheroprotective genes and their role as critical regulatory nodes in vascular homeostasis. © 2013 Elsevier Inc.
2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular PathologyOrnella Leone | John P. Veinot | Annalisa Angelini | Ulrik T. Baandrup | Cristina Basso | Gerald Berry | Patrick Bruneval | Margaret Burke | Jagdish Butany | Fiorella Calabrese | Giulia D'Amati | William D. Edwards | John T. Fallon | Michael C. Fishbein | Patrick J. Gallagher | Marc K. Halushka | Bruce McManus | Angela Pucci | E. René Rodriguez | Jeffrey E. Saffitz | Mary N. Sheppard | Charles Steenbergen | James R. Stone | Carmela Tan | Gaetano Thiene | Allard C. Van Der Wal | Gayle L. Winters
Volume 21, Issue 4, July 2012, Pages 245-274
The Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology have produced this position paper concerning the current role of endomyocardial biopsy (EMB) for the diagnosis of cardiac diseases and its contribution to patient management, focusing on pathological issues, with these aims:Determining appropriate EMB use in the context of current diagnostic strategies for cardiac diseases and providing recommendations for its rational utilizationProviding standard criteria and guidance for appropriate tissue triage and pathological analysisPromoting a team approach to EMB use, integrating the competences of pathologists, clinicians, and imagers. © 2012 Elsevier Inc. All rights reserved.
The pathophysiology of heart failureClinton D. Kemp | John V. Conte
Volume 21, Issue 5, September 2012, Pages 365-371
Heart failure is a clinical syndrome that results when the heart is unable to provide sufficient blood flow to meet metabolic requirements or accommodate systemic venous return. This common condition affects over 5 million people in the United States at a cost of $10-38 billion per year. Heart failure results from injury to the myocardium from a variety of causes including ischemic heart disease, hypertension, and diabetes. Less common etiologies include cardiomyopathies, valvular disease, myocarditis, infections, systemic toxins, and cardiotoxic drugs. As the heart fails, patients develop symptoms which include dyspnea from pulmonary congestion, and peripheral edema and ascites from impaired venous return. Constitutional symptoms such as nausea, lack of appetite, and fatigue are also common. There are several compensatory mechanisms that occur as the failing heart attempts to maintain adequate function. These include increasing cardiac output via the Frank-Starling mechanism, increasing ventricular volume and wall thickness through ventricular remodeling, and maintaining tissue perfusion with augmented mean arterial pressure through activation of neurohormonal systems. Although initially beneficial in the early stages of heart failure, all of these compensatory mechanisms eventually lead to a vicious cycle of worsening heart failure. Treatment strategies have been developed based upon the understanding of these compensatory mechanisms. Medical therapy includes diuresis, suppression of the overactive neurohormonal systems, and augmentation of contractility. Surgical options include ventricular resynchronization therapy, surgical ventricular remodeling, ventricular assist device implantation, and heart transplantation. Despite significant understanding of the underlying pathophysiological mechanisms in heart failure, this disease causes significant morbidity and carries a 50% 5-year mortality. © 2012 Elsevier Inc. All rights reserved.
Adiponectin gene expression and adipocyte diameter: A comparison between epicardial and subcutaneous adipose tissue in menClara Bambace | Mariassunta Telesca | Elena Zoico | Anna Sepe | Debora Olioso | Andrea Rossi | Francesca Corzato | Vincenzo Di Francesco | Alessandro Mazzucco | Francesco Santini | Mauro Zamboni
Volume 20, Issue 5, September 2011, Page
Introduction: Interest has recently focused on epicardial fat, but little is known about epicardial adipocyte size and its relation with insulin resistance and adipokines. Methods: Biopsies were collected from subcutaneous, epicardial-, and peritoneal fat from 21 males undergoing elective cardiac surgery either for coronary artery bypass grafting (n=11) or for valve replacement (n=10). We assessed epicardial adipocyte size, comparing it with that from subcutaneous fat and peritoneal fat. The adipocyte size was determined by using collagenase digestion of adipose tissue, separation of adipocytes by centrifugation, methylene blue staining of the nuclei, and measurement of the cell diameter. Patient's weight, height, body mass index, waist, as well as glucose, insulin, homeostatic model assessment index, adiponectin, and leptin serum levels were determined. Adiponectin mRNA levels were determined by real-time polymerase chain reaction on subcutaneous fat and epicardial fat biopsies. Results: Adipocytes in epicardial fat were significantly smaller than those in subcutaneous and peritoneal fat. The adipocyte size in epicardial fat correlated positively with insulin resistance and serum leptin, and correlated negatively with serum and mRNA expression of adiponectin. Adiponectin mRNA expression in epicardial fat was significantly lower than in subcutaneous fat. Adipocyte size in epicardial fat was significantly smaller in valve-replacement patients than in coronary artery bypass graft patients. Adiponectin gene expression was lower in the latter than in the former, although not significantly. Conclusions: Adipocytes in epicardial fat are smaller than those in peritoneal and subcutaneous fat. Adipocyte size, both in epicardial and in subcutaneous fat, is positively related with insulin resistance, shows negative association with local adiponectin gene expression, and is decreased in subjects with coronary artery disease. Adiponectin gene expression is significantly lower in epicardial- than in subcutaneous fat. © 2011 Elsevier Inc. All rights reserved.
Vascular fibrosis in atherosclerosisTao Hua Lan | Xiong Qing Huang | Hong Mei Tan
Volume 22, Issue 5, September 2013, Pages 401-407
Vascular fibrosis, characterized by reduced lumen diameter and arterial wall thickening attributable to excessive deposition of extracellular matrix (ECM), links with many clinical diseases and pathological progresses including atherosclerosis. It involves proliferation of vascular smooth muscle cell (VSMC), accumulation of ECM and inhibition of matrix degradation. The risk factors associated with cardiovascular disease, including hypertension, hyperglycemia, dyslipidemia and hyperhomocysteinemia (HHcy), are also suggested as initiation and progression factors of vascular fibrosis. Vascular fibrosis has been found to relate to renin-angiotensin-aldosterone system (RAAS), oxidative stress, inflammatory factors, growth factors and imbalance of endothelium-derived cytokine secretion. Angiotensin II (Ang II) and aldosterone, the circulating effector hormones of RAAS, are recognized as responsible for the pathophysiology of vascular fibrosis. Transforming growth factor-beta (TGF-beta) plays a critical role in ECM accumulation and vascular remodeling via up-regulating the production of several agents including connective tissue growth factor (CTGF) and fibroblast growth factor. An imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) results in collagen accumulation and adverse matrix remodeling. Aberrant expression or function of peroxisome proliferator-activated receptor gamma (PPAR gamma) is also associated with, and very likely contributes to, the progression of pathological fibrosis and vascular remodeling. In this review, we discuss the pathogenesis of vascular fibrosis in atherosclerosis with focus on the networking among main responsible mediators. The main pathophysiologic factors leading to vascular fibrosis will also be discussed. © 2013 Elsevier Inc.
Animal models of abdominal aortic aneurysm and their role in furthering management of human diseaseAlexandra Trollope | Joseph V. Moxon | Corey S. Moran | Jonathan Golledge
Volume 20, Issue 2, March 2011, Pages 114-123
Abdominal aortic aneurysm is a common degenerative disorder associated with sudden death due to aortic rupture. Current therapy is limited to open surgical repair of the aorta or endovascular placement of covered stents to exclude the abdominal aortic aneurysm from the circulation. A number of different animal models have been developed in order to study abdominal aortic aneurysm in an effort to advance current management deficiencies. Large animal models have been mostly used to assist in developing novel methods to surgically treat abdominal aortic aneurysms. Small animal models, particularly those developed in rodents, have been employed to further the understanding of the mechanisms involved in abdominal aortic aneurysm in order to identify potential new medical treatments. It is expected that findings from these animal models will contribute importantly to new treatments for human abdominal aortic aneurysm. This review explores the animal models which are used in abdominal aortic aneurysm research and highlights their advantages and disadvantages. © 2011 Elsevier Inc.
The aortic valve microenvironment and its role in calcific aortic valve diseaseCindy Ying Yin Yip | Craig A. Simmons
Volume 20, Issue 3, May 2011, Pages 177-182
In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa microenvironment is permissive to pathological development. The cellular microenvironment in the aortic valve is defined by a variety of biomechanical-, biochemical-, and extracellular-mediated factors, some of which are unique to the fibrosa. Growing evidence supports the role of these microenvironmental cues in the local regulation of side-specific valve cell phenotypes and focal pathological alterations, revealing new insights into the cellular and molecular processes that contribute to calcific aortic valve disease. © 2011 Elsevier Inc.
Causes and histopathology of ascending aortic disease in children and young adultsDeepali Jain | Harry C. Dietz | Gretchen L. Oswald | Joseph J. Maleszewski | Marc K. Halushka
Volume 20, Issue 1, January 2011, Pages 15-25
Background: Ascending aortic diseases (aneurysms, dissections, and stenosis) and associated aortic valve disease are rare but important causes of morbidity and mortality in children and young adults. Certain genetic causes, such as Marfan syndrome and congenital bicuspid aortic valve disease, are well known. However, other rarer genetic and nongenetic causes of aortic disease exist. Methods: We performed an extensive literature search to identify known causes of ascending aortic pathology in children and young adults. We catalogued both aortic pathologies and other defining systemic features of these diseases. Results: We describe 17 predominantly genetic entities that have been associated with thoracic aortic disease in this age group. Conclusions: While extensive literature on the common causes of ascending aortic disease exists, there is a need for better histologic documentation of aortic pathology in rarer diseases. © 2011 Elsevier Inc. All rights reserved.
DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery diseaseAna Paula Bazo | Décio Salvadori | Ricardo A F Salvadori | Luciandro P. Sodré | Glenda N. Da Silva | Elaine A. De Camargo | Lúcia R. Ribeiro | Daisy Maria Fávero Salvadori
Volume 20, Issue 1, January 2011, Page
Background: Atherosclerotic coronary artery disease (CAD) is a multifactorial process that appears to be caused by the interaction of environmental risk factors with multiple predisposing genes. It is nowadays accepted that increased levels of DNA damage induced by xenobiotics play an important role in the early phases of atherogenesis. Therefore, in this study, we focus on determining whether genetic variations in xenobiotic-metabolizing [glutathione-S-transferase theta 1 (GSTT1), glutathione-S-transferase mu 1 (GSTM1), cytochrome P450 IIEI (CYP2E1)] and DNA repair [X-ray cross-complementing group 1 (XRCC1)] genes might be associated with increased risk for CAD. Methods: A case-control study was conducted with 400 individuals who underwent subjected to coronary angiography. A total of 299 were patients diagnosed with effective coronary atherosclerosis (case group; >20% obstructive lesion), and 101 (control group) were individuals diagnosed as negative for CAD (<20% obstructive lesions). The polymorphism identifications for GSTM1 and GSTT1, and for CYP2E1 and XRCC1 genes were performed by polymerase chain reaction (PCR) amplification and by PCR-RFLP, respectively. Results and conclusions: The XRCC1 homozygous wild-type genotype Arg/Arg for codon 399 was statistically less pronounced in the case subjects (21.4%) than in controls (38.5%); individuals with the variant XRCC1 genotype had a 2.3-fold increased risk for coronary atherosclerosis than individuals with the wild-type genotype (OR=2.3, 95% CI=1.13-4.69). Conversely, no association between GSTM1, GSTT1, and CYP2E1gene polymorphisms and coronary atherosclerosis was detected. The results provide evidence of the role of DNA damage and repair in cardiovascular disease. © 2011 Elsevier Inc. All rights reserved.
PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditisManuela Nebuloni | Fabio Pasqualini | Pietro Zerbi | Eleonora Lauri | Alberto Mantovani | Luca Vago | Cecilia Garlanda
Volume 20, Issue 1, January 2011, Page
Introduction: The long pentraxin 3 is involved in innate resistance to pathogens, controlling inflammation and extracellular matrix remodeling. Moreover, pentraxin 3 plays a nonredundant role in the regulation of cardiac tissue damage in mice and, recently, it has been proposed as a new candidate marker for acute and chronic heart diseases. However, the actual localization and cellular sources of pentraxin 3 in ischemic and infectious cardiac pathology have not been carefully defined. Methods: In this study, using immunohistochemistry, we analyzed pentraxin 3 expression in the heart tissues of patients with acute myocardial infarction at different time points after the ischemic event. In addition, we studied the heart tissues of patients with infectious myocarditis (fungi, bacteria, and protozoa) and patients who died of noncardiac events with normal heart histology. Results: In acute myocardial infarction cases, we observed pentraxin 3 localized within and around ischemic lesions. On the contrary, no pentraxin 3 was observed in normal heart areas. In early ischemic lesions, pentraxin 3 was localized primarily in granulocytes; in more advanced acute myocardial infarction, pentraxin 3 positivity was found in the interstitium and in the cytoplasm of macrophages and the endothelium, whereas most granulocytes did not express pentraxin 3, presumably as a consequence of degranulation. In infectious myocarditis, pentraxin 3 was present and localized within and around histological lesions, associated with macrophage, endothelial cell, and, more rarely, myocardiocyte and granulocyte positivities. As observed in acute myocardial infarction patients, no pentraxin 3 staining was found in normal heart areas. Conclusions: Thus, neutrophils are an early source of pentraxin 3 in acute myocardial infarction and presumably other inflammatory heart disorders. Subsequently, in acute myocardial infarction and infectious myocarditis, pentraxin 3 is produced by macrophages, the endothelium, and, to a lesser extent, myocardiocytes, and localized in the interstitium. © 2011 Elsevier Inc. All rights reserved.
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through SrcKatherine Kun Lu | Dan Trcka | Michelle P. Bendeck
Volume 20, Issue 2, March 2011, Pages 71-76
Background: Discoidin domain receptor 1 (DDR1) is a collagen-binding receptor tyrosine kinase which mediates the migration and proliferation of several cell types. DDR1 is expressed in vascular smooth muscle cells (SMCs) during atherosclerosis and following vascular injury, mediating cell migration and contributing to disease pathogenesis. However, very little is known about the signaling pathways activated by the DDR1 in SMCs. Therefore we have studied the involvement of Src and mitogen-activated protein kinase (MAPK) signaling pathways downstream of DDR1 in vascular SMCs. Methods: Cells harvested from DDR1-/-, DDR1+/+ mice, and DDR1+/+ cells overexpressing human DDR1b (O/hDDR1b) were used for these studies. Results: Stimulation of O/hDDR1b cells with type I collagen resulted in increased tyrosine phosphorylation of DDR1. The non-receptor kinase Src co-immunoprecipitated with DDR1, and the Src inhibitor PP2 inhibited type I collagen-induced tyrosine phosphorylation of DDR1. Stimulation of DDR1-expressing cells with collagen resulted in the activation of extracellular signal-regulated kinase 1/2 (ERK1/2); however, ERK1/2 was not activated in DDR1-deficient cells. By contrast, p38 MAPK (p38) was activated by collagen stimulation in both DDR1-expressing and DDR1-deficient cells. Treatment with PP2 attenuated DDR1-dependent ERK1/2 activation, but not p38 activation. Finally, treatment of SMCs with PP2, or the MEK inhibitor PD98059, inhibited migration toward type I collagen in a chemotaxis chamber. However, PP2 but not PD98059 had a greater effect in reducing the migration of DDR1+/+ cells compared to DDR1-/- cells, suggesting that Src but not ERK1/2 was important in regulating DDR1-dependent SMC migration. Conclusions: Type I collagen induces SMC migration through DDR1 and this is mediated via Src signaling. © 2011 Elsevier Inc.
Emerging role of epigenetics and miRNA in diabetic cardiomyopathyMohamed Asrih | Sabine Steffens
Volume 22, Issue 2, March 2013, Pages 117-125
The prevalence of heart failure independent of coronary artery disease and hypertension is increasing rapidly in diabetic patients. Thus, this pathophysiology has been recognized as a distinct clinical entity termed "diabetic cardiomyopathy." Several studies support the notion that diabetes is a threatening insult for the myocardium resulting in functional, cellular, and structural changes manifesting as a cardiac myopathy. Recent data suggested that epigenetics including DNA and histone modifications as well as microRNAs play an important role in the development of cardiac diseases. The role of epigenetics in diabetes is largely recognized; however, its role in diabetes-associated cardiomyopathy remains elusive. Thus, molecular, cellular, and functional modulations in the diabetic cardiomyopathy will be investigated in this review. Moreover, particular attention will be drawn on the epigenetic mechanisms that may play an important role in the pathophysiology of diabetic cardiomyopathy. © 2013 Elsevier Inc.
Early obstruction of decellularized xenogenic valves in pediatric patients: Involvement of inflammatory and fibroproliferative processesIwona Cicha | André Rüffer | Robert Cesnjevar | Martin Glöckler | Abbas Agaimy | Werner G. Daniel | Christoph D. Garlichs | Sven Dittrich
Volume 20, Issue 4, July 2011, Pages 222-231
Background: Decellularization of pulmonary valve substitutes is believed to eliminate immunogenicity and improve conduit durability. This study focused on a detailed histopathological and immunohistochemical analysis of explanted Matrix P plus valves, following their early obstruction in pediatric patients. Methods: Occurrence of fibrosis, scar formation, neovascularization, and inflammatory infiltrates were determined in longitudinal sections of four valve specimens explanted after 12-15 months. Valves were immunohistochemically analyzed for presence of different subtypes of inflammatory cells. The expression of smooth muscle actin and connective tissue growth factor was determined. Results: We observed a foreign body-type reaction accompanied by severe fibrosis and massive neointima formation around decellularized porcine valve wall, whereas the equine pericardial patch remained separated from porcine layer and acellular. Re-cellularization of decellularized matrix was low, and neovascularization was observed only in the neointima and scar tissue. Inflammatory infiltrates, composed mainly of T cells, B cells, and plasma cells, as well as the presence of dendritic cells, macrophages, and mast cells were detected in the tissue surrounding the porcine matrix. In the fibrous tissue, overexpression of connective tissue growth factor was observed. The leaflets remained functional, with normal endothelialization and no degenerative changes. Control pre-implant samples of Matrix P plus valve revealed incomplete decellularization of porcine matrix, which may have contributed to increased immunogenicity of these conduits. Conclusions: Early obstruction of decellularized Matrix P plus valve is associated with massive inflammatory reaction and exaggerated fibrotic scaring around porcine conduit wall. Detailed studies will be necessary to determine factors that contribute to remnant immunogenicity of decellularized grafts. © 2010 Elsevier Inc. All rights reserved.
Recommendations for processing cardiovascular surgical pathology specimens: A consensus statement from the Standards and Definitions Committee of the Society for Cardiovascular Pathology and the Association for European Cardiovascular PathologyJames R. Stone | Cristina Basso | Ulrik T. Baandrup | Patrick Bruneval | Jagdish Butany | Patrick J. Gallagher | Marc K. Halushka | Dylan V. Miller | Robert F. Padera | Stanley J. Radio | Mary N. Sheppard | Kim Suvarna | Carmela D. Tan | Gaetano Thiene | Allard C. Van Der Wal | John P. Veinot
Volume 21, Issue 1, January 2012, Pages 2-16
With the advent of molecular subclassification of diseases, much consideration should be given to the proper processing of cardiovascular surgical pathology specimens to maximize patient care. Such specimens include endomyocardial biopsies, cardiac myectomy specimens, cardiac apical core segments, resected cardiac valves, pericardial biopsies, resected segments of aorta, cardiac tumors, vascular stents, vascular grafts, cardiac devices, resected veins, arterial biopsies including temporal artery biopsies and hearts removed during cardiac transplantation. In this report, the Standards and Definitions Committee of the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology present consensus guidelines for the gross description, sectioning, processing, and staining of these specimens. This report is presented to aid pathologists, pathology assistants, and clinicians in maximizing the diagnostic utility of cardiovascular surgical pathology specimens for enhanced patient care. © 2012 Elsevier Inc. All rights reserved.
Isolated thoracic aortitis: Clinicopathological and immunohistochemical study of 11 casesJan Laco | Ivo Steiner | Tomas Holubec | Jan Dominik | Zdenka Holubcova | Jan Vojacek
Volume 20, Issue 6, November 2011, Pages 352-360
Isolated thoracic aortitis (ITA) is diagnosed in a variable proportion of patients operated on for dilation/aneurysm of ascending aorta. The etiopathogenesis of ITA remains unclear. We studied 11 cases of ITA in order to determine the role of IgG4-mediated immune responses in its pathogenesis. The series included nine women and two men aged 52-79 years. All patients developed aortic incompetence due to dilation/aneurysm of ascending aorta. None of the patients had a history of IgG4-related disease neither did they develop features of such disease during the follow-up period. The microscopic findings included the presence of lymphoplasmacellular fibrosing infiltrate of varied intensity involving the adventitia and media of aorta. This inflammation was associated with severe medial elastic fiber defects. Obliterative phlebitis of the vasa vasorum was absent. Immunohistochemically, the inflammatory infiltrate comprised T- and B-lymphocytes as well as plasma cells. The plasma cell population was polyclonal with a predominance of IgG-producing cells. In all the cases, IgG4-producing plasma cells were detected. In five cases, the count exceeded 20 cells per high-power field. The IgG4/IgG ratio ranged from 0.07 to 0.98 (median 0.55). In six cases with the ratio >0.50, severe adventitial fibrosis was present. To the best of our knowledge, ours is the first study focused on investigating the role of IgG4-positive plasma cells in the development of ITA. Our results suggest that a subset of ITA may represent aortic manifestation of IgG4-related disease. Further research is necessary in order to clarify this issue. © 2011 Elsevier Inc. All rights reserved.
Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matricesPeter A. Galie | Margaret V. Westfall | Jan P. Stegemann
Volume 20, Issue 6, November 2011, Pages 325-333
Introduction: The fibroblast-myofibroblast transition is an important event in the development of cardiac fibrosis and scar formation initiated after myocardial ischemia. The goals of the present study were to better understand the contribution of environmental factors to this transition and determine whether myofibroblasts provide equally important feedback to the surrounding environment. Methods: The influence of matrix stiffness and serum concentration on the myofibroblast transition was assessed by measuring message levels of a panel of cardiac fibroblast phenotype markers using quantitative reverse transcriptase polymerase chain reaction. Cell-mediated gel compaction measured the influence of environmental factors on cardiac fibroblast contractility. Immunohistochemistry characterized alpha-smooth muscle actin expression and cell morphology, while static and dynamic compression testing evaluated the effect of the cell response on the mechanical properties of the cell-seeded collagen hydrogels. Results: Both reduced serum content and increased matrix stiffness contributed to the myofibroblast transition, as indicated by contractile compaction of the gels, increased message levels of col3α1 and alpha-smooth muscle actin, and a less stellate morphology. However, the effects of serum and matrix stiffness were not additive. Mechanical testing indicated that reduced serum content increased the initial elastic modulus of cell-seeded gels and that gels lost their viscous character with time. Conclusions: The results suggest that reduced serum and increased matrix stiffness promote the myofibroblast phenotype in the myocardium. This transition both enhances and is promoted by matrix stiffness, indicating the presence of positive feedback that may contribute to the pathogenesis of cardiac fibrosis. © 2011 Elsevier Inc. All rights reserved.
Phosphate: A stealthier killer than previously thought?Emilio Gonzalez-Parra | Jose Tuñón | Jesus Egido | Alberto Ortiz
Volume 21, Issue 5, September 2012, Pages 372-381
The kidneys excrete excess dietary phosphate, and patients with chronic kidney disease may suffer from phosphate overload and hyperphosphatemia. In chronic kidney disease, hyperphosphatemia has emerged as a risk factor for vascular calcification, cardiovascular mortality, left ventricular hypertrophy, and progression of chronic kidney disease. Serum phosphate at the upper limits of normal has also been associated with adverse outcomes in patients with relatively preserved kidney function. Of note, hyperphosphatemia is not a sensitive indicator of phosphate overload. In this regard, increased circulating fibroblast growth factor-23, a phosphatonin that is released in response to phosphate overload, is independently associated with adverse outcomes in patients with and without chronic kidney disease. Direct effects of extracellular phosphate on vascular calcification or cardiovascular cell biology; adverse consequences of adaptive mechanisms activated to limit phosphate overload, such as left ventricular hypertrophy induced by fibroblast growth factor-23; or epidemiological associations of additional cardiovascular risk factors with chronic kidney disease may underlie these observations. We now review the pathophysiology of phosphate, its relationship with cardiovascular outcomes, the potential consequences for patient care related to dietary phosphate and phosphate binders, and the clinical relevance for patients without overt chronic kidney disease. © 2012 Elsevier Inc. All rights reserved.
Primary and metastatic cardiac tumors: Imaging characteristics, surgical treatment, and histopathological spectrum: A 10-year-experience at a German heart centerThomas Strecker | Johannes Rösch | Michael Weyand | Abbas Agaimy
Volume 21, Issue 5, September 2012, Pages 436-443
Background: Tumors of the heart are rare compared to other cardiac diseases. Their clinical symptoms vary from absent to nonspecific. This great variation and general paucity of symptoms related to cardiac tumors often result in delayed diagnosis and treatment. Methods: We retrospectively evaluated all patients who underwent cardiac surgery for a space-occupying lesion in the observation period between 2000 and 2010 at our hospital. Clinicopathological features, imaging characteristics, and disease outcomes were analyzed, and the results were compared with the available English literature. Results: During the last 10 years, 84 patients underwent resection of a cardiac mass at our center, i.e., 0.85% of the total number (n=9829) of all cardiac surgical operations performed in that period. The part of primary cardiac tumors was 73.8% (n=62; 59 benign and 3 malign tumors). In nine cases (10.7%), secondary cardiac tumors represented metastases of malignant tumors from different extracardiac locations. In 13 cases (15.5%), the mass represented cardiac thrombus. The majority of cardiac tumors were benign, and most of them were cardiac myxomas (n=48). Papillary fibroelastoma was the second most common primary tumor. Conclusions: Our data in this study were comparable to the literature regarding the frequency and allocation of the different cardiac tumors. Our data are in line with previous reports that patients with benign cardiac tumors profit from surgical resection compared to those subjected to conservative treatment with the risk of central or peripheral embolisms. Concerning malignant primary cardiac tumors and cardiac metastases, surgery represents only a palliative strategy in most of the cases. © 2012 Elsevier Inc. All rights reserved.
Protective effect of grape seed proanthocyanidins against cholesterol cholic acid diet-induced hypercholesterolemia in ratsMohana Thiruchenduran | Navin Alukkathara Vijayan | Jayachandaran Kasevan Sawaminathan | Sivasitambaram Niranjali Devaraj
Volume 20, Issue 6, November 2011, Pages 361-368
Background: Dietary cholesterol plays an important role in the development of atherogenesis and cardiovascular diseases. We explored the prospective effect of grape seed proanthocyanidins in controlling hypercholesterolemia induced oxidative injury and apoptosis in atherogenic animals. Methods: Four groups of male Wistar rats (250-300 g) were used for the study. Group I served as control and received vehicle (saline) alone, Group II served as the induction group fed with a high-cholesterol diet (rat chow supplemented with 4% cholesterol and 1% cholic acid-CC diet) for 30 days, Group III served as drug control and was treated with grape seed proanthocyanidins (100 mg/kg body weight) orally for 30 days, and Group IV animals were fed with CC diet for 30 days along with grape seed proanthocyanidins (100 mg/kg body weight) orally. Results: CC diet induced an abnormal increase in lipid peroxidation, tissue cholesterol, triglyceride, serum low-density lipoprotein, and very low density lipoprotein, and decreased the high-density lipoprotein concentration. Altered activity of cardiac and serum creatine kinase, accompanied by a decreased cardiac enzymatic and nonenzymatic antioxidant defense system and an increase in the expression of cytochrome c and caspases-3, was observed in CC diet-fed rats. These changes were partially restored in the grape seed proanthocyanidin-treated group. Conclusion: Grape seed proanthocyanidins have cardioprotective effects against CC diet-induced hypercholesterolemia via their ability to reduce, directly or indirectly, free radicals in the myocardium. © 2011 Elsevier Inc. All rights reserved.
Extracellular vesicle microRNA transfer in cardiovascular diseaseSamarjit Das | Marc K. Halushka
Volume 24, Issue 4, January 2015, Pages 199-206
© 2015 Elsevier Inc.microRNAs (miRNAs) are a class of small regulatory RNAs that decrease protein translation to fine-tune cellular function. Recently, miRNAs were found to transfer from a donor cell into a recipient cell via exosomes and microparticles. These microvesicles are found in blood, urine, saliva, and other fluid compartments. miRNAs are delivered with intact functionality and have been repeatedly shown to regulate protein expression in recipient cells in a paracrine fashion. Thus, transported miRNAs are a new class of cell-to-cell regulatory species. Exosomal miRNA transfer is now being reported in cardiovascular systems and disease. In the blood vessels, this transfer modulates atherosclerosis and angiogenesis. In the heart, it modulates heart failure, myocardial infarction, and response to ischemic preconditioning. This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes.
Transcriptional regulation of heart valve development and diseaseElaine E. Wirrig | Katherine E. Yutzey
Volume 20, Issue 3, May 2011, Pages 162-167
Aortic valve disease is estimated to affect 2% of the United States population. There is increasing evidence that aortic valve disease has a basis in development, as congenital valve malformations are prevalent in patients undergoing valve replacement surgery. In fact, a number of genetic mutations have been linked to valve malformations and disease. In the initial stages of aortic valve pathogenesis, the valvular interstitial cells become activated, undergo cell proliferation, and participate in extracellular matrix remodeling. Many of these cell properties are shared with mesenchymal progenitor cells of the normally developing valves and bones. Historically, valve calcification was thought to be a passive process reflecting end-stage disease. However, recent evidence describes the increased expression of transcription factors in diseased AoV that are common to valvulogenic and osteogenic processes. These studies lend support to the idea that a developmental gene program is reactivated in aortic valve disease and may contribute to the molecular mechanisms underlying valve calcification in disease. © 2011 Elsevier Inc.
Histopathologic correlates of myocardial improvement in patients supported by a left ventricular assist deviceAna Maria Segura | O. H. Frazier | Zumrut Demirozu | L. Maximilian Buja
Volume 20, Issue 3, May 2011, Pages 139-145
Background: Left ventricular assist devices unload the failing heart and improve hemodynamic function and tissue architecture. In some patients improvement allows for left ventricular assist device removal. We retrospectively compared histologic features in patients who were weaned off left ventricular assist device support with those who remained on support without evidence of clinical remission. Methods: We graded left ventricular core samples taken at implantation on a scale we designed for evaluating severity and extent of fibrosis and hypertrophy. We correlated the grades with a computerized semiquantitative analysis of picrosirius-red and Masson's trichrome-stained sections. We evaluated interstitial (10×), perivascular (20×), and replacement (4×) fibrosis. Hypertrophy was assessed by myocyte diameter, cytoplasmic area, and nuclear/cytoplasmic ratio. Results: All patients (N=17) underwent left ventricular assist device implantation for heart failure. In eight patients improvement allowed left ventricular assist device removal. The groups did not differ in age (24.1 vs. 25 years, P=.4) or mean time on left ventricular assist device support (506 vs. 414 days, P=.24). All mean measures showed significantly less hypertrophy in the left ventricular assist device-removal group than in the nonremoval group, respectively (cytoplasmic area, 58.00 vs. 77.18 μm2, P=.021; myocyte diameter, 20.32 vs. 25.35 μm, P=.004; nuclear/cytoplasmic ratio, 11.04 vs. 8.69, P=.053). Although not statistically significant, the left ventricular assist device-removal group tended toward less overall fibrosis than the nonremoval group (11.57 vs. 13.24, P=.214). Conclusions: Left ventricular assist device-removal patients had less hypertrophy and fibrosis overall than did nonremoval patients. These findings may help identify patients with a higher probability of left ventricular assist device removal and myocardial recovery. © 2011 Elsevier Inc.
The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loopsChen Li | Songyi Xu | Avrum I. Gotlieb
Volume 22, Issue 1, January 2013, Pages 1-8
Calcific aortic valve disease (CAVD) is the most common form of heart valve disease in Western society and results in the second most common cardiovascular surgery performed. Despite its prevalence, high morbidity, and high mortality, the pathogenesis of CAVD still eludes our understanding. This review article brings together experimental in vivo and in vitro as well as human in vivo research in cell and molecular pathobiology to construct an overarching hypothesis regarding the development and progression of CAVD. We focus on injury, cell dysfunction, and disruptive biologic and physical forces, and how they function in positive feedback loops that result in the eventual calcification of the valve. We propose that injury, inflammation, matrix remodeling, and physical forces are all processes that influence each other and alter the normal physiologic functions of a key player in the pathogenesis of CAVD: the valve interstitial cell. We propose that the different phenotypes of the valve interstitial cell play essential roles in the pathogenesis of CAVD. We describe important physiologic processes which become dysfunctional including proliferation, migration, secretion of growth factors, chemokines and cytokines, and matrix remodeling. We also describe the emergence of chondrogenesis and osteogenesis in the fibrotic valve that lead to the severe clinical conditions of CAVD. CAVD appears to have a complex pathogenesis which fortunately can be studied in vitro and in vivo to identify ways to detect, treat, and prevent CAVD. © 2013 Elsevier Inc.
Primary cardiac tumors: 32 Years of experience from a Spanish tertiary surgical centerManuel Barreiro | Alfredo Renilla | Jaime M. Jimenez | María Martin | Tarique Al Musa | Laura Garcia | Vicente Barriales
Volume 22, Issue 6, November 2013, Pages 424-427
Introduction: Primary cardiac tumors are rare entities with an autopsy frequency ranging between 0.001% and 0.3%. Our objective was to review 32 years of experience from a Spanish tertiary surgical center. Method: We collected data on 73 patients with a histopathological diagnosis of a primary cardiac tumor in a retrospective analysis from 1979 to 2012. Tissue samples were obtained either at surgery or from necropsy and subsequently divided into benign and malignant groups. Results: Benign neoplasms accounted for 84.9% of cases. The average age at diagnosis was 61 years, and tumors were twice as frequent among women. It was an incidental finding in one quarter of patients. In symptomatic patients, the typical presentation was of cardioembolic stroke or of congestive symptoms. Myxoma (93.5%) was the most common diagnosis, typically affecting the left atrium (74.2%). Surgical resection was curative for 95% of these patients. Malignant tumors represented 15.1% of cases with an average age at diagnosis of 50 years. Over 90% of these patients were symptomatic at presentation with the cardinal symptom being heart failure. Undifferentiated sarcoma was the most frequent malignant tumor (36.4%). Less than 20% of patients were alive 1 year after diagnosis despite the treatment. Conclusions: In our study, primary cardiac tumors were insidious. The most common was left atrial myxoma in which surgical resection was considered curative. Undifferentiated sarcoma was the most frequent malignant tumor. Malignant neoplasms carried a worse prognosis with unsuccessful total excision and the presence of metastatic disease being markers of an adverse outcome. © 2013 Elsevier Inc. All rights reserved.
Atrial fibrillation from the pathologist's perspectiveDomenico Corradi
Volume 23, Issue 2, March 2014, Pages 71-84
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical practice, is associated with increased morbidity and mortality. Electrophysiologically, it is characterized by a high rate of asynchronous atrial cell depolarization causing a loss of atrial contractile function and irregular ventricular rates. For a long time, AF was considered as a pure functional disorder without any structural background. Only in recent years, have new mapping and imaging techniques identified atrial locations, which are very often involved in the initiation and maintenance of this supraventricular arrhythmia (i.e. the distal portion of the pulmonary veins and the surrounding atrial myocardium). Morphological analysis of these myocardial sites has demonstrated significant structural remodeling as well as paved the way for further knowledge of AF natural history, pathogenesis, and treatment. This architectural myocardial disarrangement is induced by the arrhythmia itself and the very frequently associated cardiovascular disorders. At the same time, the structural remodeling is also capable of sustaining AF, thereby creating a sort of pathogenetic vicious circle. This review focuses on current understanding about the structural and genetic bases of AF with reference to their classification, pathogenesis, and clinical implications. © 2014 Elsevier Inc.


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Fixed PriceDelivery by October 24, 2013
I am using a Yootheme (on warp framwork) and using the widget kit to display a slideshow. I need to overlay four images over the slideshow as well as a script for a form.
Please only apply for this job if you can start immediately.
Please put the word "immediately" at the top of your reply so I know you can start immediately.
About the Client
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2,297 Hours

subset: commoncrawl


text: Advertising events such as the yacht club grand prix and a classic boat show, these posters will have you racing to the harbor. The wistful vintage styling and standard nautical colors make this panel a clear favorite for sailing enthusiasts. 24" panel, frames are about 5 3/4", panels have 36 frames, from the 'Sail Away' collection by Rosemarie Lavin for Windham Fabrics.


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Review of Barry Humphries farewell show Eat, Pray, Laugh in Adelaide
- From: adelaidenow
- January 21, 2013
IF this really is the farewell appearance by Barry Humphries' indelible characters, then he went out with a bang!
Hard to believe we may never see Sir Les Patterson, Sandy Stone and Dame Edna again, live on the Her Maj stage but it was great to see them going out on top.
Simon Phillips has put together a wonderful structure that keeps the show and the characters flowing in a polished evening from a master comedian.
There was nothing miserable about Sir Les, as he got cooking despite drastic gastro interludes, with plenty of cheese from his backing group The Condiments.
Sandy seemed genuinely touched by all the excitement, and ethereally took us on a tiny bike ride down memory lane, and then into the genuine gods.
Edna could have taken it easy on the suspecting audience but thank God she was merciless on her willing victims, from the back-row paupers to the quivering housewives.
There was song and dance, a sacrilegious surprise guest, an avalanche of laughs and a curtain of tears as Humphries himself finally, almost said goodbye....
It really is a special night out that shouldn't be missed, so grab a ticket and farewell a lot of legends, who remind us, what makes us, eat, pray and barf!
Eat, Pray, Laugh
Barry Humphries
Four Stars
Her Majestys
Until Jan 27
Review by Matt Byrne


text: EconStor Collection: http://hdl.handle.net/10419/44602 2016-09-28T11:56:58Z Global political ethnography: A methodological approach to studying global policy regimes http://hdl.handle.net/10419/122296 Title: Global political ethnography: A methodological approach to studying global policy regimes Authors: Stepputat, Finn; Larsen, Jessica Abstract: At a time when changing world orders, new actors, and new technologies transform global policy regimes, this DIIS Working Paper argues that a methodology for studying such regimes ethnographically seem to be emerging across various disciplines. The purpose of the paper is twofold: firstly, we seek to contribute to the dialogue on ethnographic and practice-oriented approaches that is growing across disciplines, from anthropology to political science and International Relations, and provide some common ground for this dialogue. Secondly, by reviewing an extensive literature, we focus on methodological discussions concerning how to approach the highly complex global policy processes that are currently developing. What are the appropriate empirical scale(s) and units of analysis of a global political ethnography? How do we identify sites, encounters, situations and materials where ethnographic approaches can generate different and maybe more critical insights than more conventional approaches? And how are the voices and practices of actors operating at different scales and in different sites balanced and connected in the policy analysis? 2015-01-01T00:00:00Z Non-state armed groups in the Myanmar peace process: What are the future options? http://hdl.handle.net/10419/122295 Title: Non-state armed groups in the Myanmar peace process: What are the future options? Authors: Kyed, Helene Maria; Gravers, Mikael Abstract: In Myanmar/Burma the government and the many ethnic non-state armed groups (NSAGs) are close to signing a national ceasefire agreement that will end almost 65 years of conflict in the country's resource-rich borderlands. This is taking place alongside a transition from totalitarian military rule towards democracy, and a rapid influx of international aid agencies and foreign investors. While there is progress in the peace negotiations, the process has been contested and fighting has continued in Kachin state. A key controversy concerns the future status of the many NSAGs that represent different ethnic nationalities, such as the Karen and the Mon. The NSAG leaders demand a political settlement that allows them to retain arms and political positions within a federalist system. The government has now agreed to discuss a federal system, but this is not backed by the powerful Burmese army generals. Moreover, the term 'federalism' can have many meanings. Left out of the peace negotiation talks has been any open discussion of what will happen to the many middleand lower-ranked armed actors after an agreement has been reached. Failure to include this may be detrimental to sustainable peace and to the building of trust in the peace settlement. This paper is a preliminary attempt to discuss the future options for the members of the ethnic NSAGs in Myanmar: what 'exit' options do the NSAG members have after decades of conflict and, for many of them, entire lives spent inside the armed groups? How do they envision their future - as armed actors, civil servants, politicians, businessmen or something else? In addressing these questions we draw on interviews held in Mon and Karen states in January 2014 and on prior research. We engage with that segment of the international peacebuilding literature which debates the transformation of ex-combatants through different forms of 'Demobilization, Disarmament and Reintegration' (DDR) programmes. A core argument of the paper is that in the Myanmar context it is highly unlikely that conventional DDR programmes will suffice to support sustainable peace and stability. This is not only due to the exceptionally low involvement of international aid agencies in the peace process, but also because of the predominant focus in DDR programmes on disarmament and on economic incentives to successful integration. In Myanmar this overlooks key political motives behind both the causes of conflict and the negotiations for peace. It also ignores the fact that the NSAGs have enjoyed decades of state-like control over territories and people. Based on this, we do not take a point of departure in disarmament, but instead outline seven different integration options. These consist of a combination of different forms of political, economic, civil society and security sector integration. We call for more in-depth analyses of the armed groups in Myanmar as a complex and dynamic set of actors with various motives, aspirations and incentives. Finally, the paper concludes by reflecting on the future role of international aid agencies in the context of the peace process. 2014-01-01T00:00:00Z On the frontier between 'high' and 'low' politics of migration in Burkina Faso - and the failure of emigration policies http://hdl.handle.net/10419/122297 Title: On the frontier between 'high' and 'low' politics of migration in Burkina Faso - and the failure of emigration policies Authors: Olsen, Anne Sofie Westh Abstract: Migration policy research is biased towards receiving countries. Furthermore, even emigration policies are generally evaluated against their ability to control migration. This article asserts that 'filling the sending-country gap' should go beyond the role of policies in shaping (or reducing) migration. It should instead reflect the broader development goals of emigration policies, taking into consideration the capabilities of sending states. In this 'age of migration', it is striking how little we know about how policies can best be used by sending states as a tool for poverty alleviation, human capital development and labor market integration - even in the face of restrictive immigration policies on the other side of the border. One should also consider the aspirations of sending states in leveraging migration for development. With a case study on Burkina Faso - a mainly south-south sending country - policymaking is brought center stage in order to explore whether the current elaboration of an emigration policy signifies a change towards migration becoming - once again - 'high' politics in Burkina Faso. 2014-01-01T00:00:00Z Cooperation or conflict in the Arctic: A literature review http://hdl.handle.net/10419/122294 Title: Cooperation or conflict in the Arctic: A literature review Authors: Olesen, Mikkel Runge Abstract: Spill-over from the Ukrainian crisis is threatening an otherwise benign international state of affairs in the Arctic, raising once more the question of whether the Arctic is likely to be a scene for cooperation or conflict in the coming years? This question has defined much International Relations research on the Arctic region even before Ukraine. This working paper takes stock of the debates between two groups of researchers, which in the paper are named respectively "warners" and "reassurers", and it argues that the field as a whole has generally become more optimistic regarding the Arctic since 2007. It argues that this optimism is due to the fact that developments in the Arctic since 2007 have generally tended to weaken the case of the "warners". And while recent spill-over from the Ukrainian crisis to the Arctic in 2014 must certainly be seen as a step in the opposite direction, the damaging effects of the crisis need not be a game-changer. 2014-01-01T00:00:00Z


text: My Room Emily's Turquoise and Black Pre-Teen Room Carrie McBride May 31, 2012 My Room Nursery & Kids Tween Home Share Pin Email Share Pin Email Name: Emily (12) Location: Prospect, KY My inspirations for this room came from my daughter and her love of aqua and black. The room centers around a large "statement" rug that is black with a large flower. We did some personalized art, mirrors...along with a calendar and chalkboard. It is a perfect hangout space and a great preteen retreat. Thanks Tracie! It's a treat to see an older kid's room! Readers, see more of Emily's room at Cleverly Inspired. (Images: Cleverly Inspired) • MY ROOM ARCHIVE • SUBMIT A BABY OR KID'S SPACE Share Pin Email


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Great demonstrations, cold Pizza, warm Soda's and a chance to win a XBox 360. A developers dream! What more can you ask for? (Don't answer that question) 🙂
Wednesday, Nov. 1st from 6:00P-8:00P
Microsoft Innovation and Technology Center
12012 Sunset Hills Road, Reston, VA 20190
How to register
http://msevents.microsoft.com/cui/eventdetail.aspx?culture=en-US&eventid=1032315199 or call 1-877-MSEVENT (1-877-673-8368) and reference 1032315199.
This one hour Introduction on building Workflow solutions will concentrate on the "How to" (demonstration) of building Workflow into .NET solutions, with a little bit of "What is" (PowerPoint) at the beginning. We will spend the bulk of the time building a demonstration application that takes you from the basics of building a simple (albeit more complex than Hello World) and slowly add additional Workflow functionality, ending with a basic Document Processing Workflow example.
Who Should Attend
Architects, Developers, and who would like to get insight and a head-start on how to build workflow into their applications.
What you will learn
– A brief background as to what Windows Workflow is, how it fits into .NET 3.0 and how it differs from BizTalk
– How to increase developer productivity with Workflow
– How to pass "work" into the Workflow
– Building custom Workflow Activities (conceptualizing Business Logic into Workflow Code)
– Communicating with your workflow
Note: This will be a developer-centric talk, with code and Workflow design for the bulk of the talk (versus PowerPoint Overview) and is meant for a Developer audience. I will be doing a series of webcasts next month that will give more of an "Overview" for Managers.
If you want to get a head start on things, feel free to download the Workflow Workshops @ www.federaldeveloper.com/workshops
Raffle Item for this event: An XBox 360 Core System. You have to be there tow win!
~ Robert Shelton


text:
Back to Main...
Swarovski Reveals Collective 2016
by BWW News Desk - September 09, 2015
Swarovski announced the 15 designers who will form the year-long Swarovski Collective 2016. This group of exceptional design talents, which includes both new and established names, will work in creative partnership with Swarovski for their Spring/Summer 2016 and Autumn/Winter 2016 collections.... (more...)
L'Oreal and Proenza Schouler Sign Deal for Luxury Fine Fragrances
by BWW News Desk - June 03, 2015
L'Oreal announced the signature of a License Agreement with Proenza Schouler for the creation and development of fine fragrances.... (more...)
H&M Celebrates The First Ten Years in an Exclusive Book
by BWW News Desk - October 24, 2014
H&M, Hennes & Mauritz, A.B., one of the world's largest fashion retailers in the world, announced a new book available in select stores on November 6 th to coincide with their Alexander Wang x H&M launch. The brand, a pioneer of designer collaborations, has dug into their archive to highlight a deca... (more...)
VIDEO: Viktor & Rolf S/S 2015 Runway Show at Paris Fashion Week
by BWW News Desk - October 07, 2014
Check out the latest collection from Viktor & Rolf from the runway during Paris Fashion Week Spring/Summer 2015!... (more...)
Fashion Photo of the Day 12/13/13 - Leslie Mann
by Rachel Stone - December 13, 2013
I had to finish out the week with one of my most favorite looks. Leslie Mann rocked a casual but chic white Viktor & Rolf jumpsuit with a Saint Laurent coat in the London premiere of Anchorman 2: The Legend Continues. We all know I live for jumpsuits, and just yesterday I talked (again) about my l... (more...)
Macy's Herald Square Unveils New Beauty and Fragrance Department
by BWW News Desk - November 15, 2013
A state-of-the-art and sophisticated shopping experience awaits shoppers as Macy's Herald Square unveils a striking new look for its signature world of beauty and fragrances today. The long-awaited reveal has been months in the making, culminating with the most dramatic makeover of a beauty departme... (more...)
Viktor & Rolf Entering Eyewear Market
by BWW News Desk - September 11, 2013
WWD reports that Dutch designers Viktor Horsting and Rolf Snoeren are branching out into eyewear with the launch of their new line for spring 2014 with France's Paget Group.... (more...)
Fashion Photo of the Day 8/7/13 - Chloe Grace Moretz
by Rachel Stone - August 07, 2013
There is something so sexy about menswear on a woman. Its confident, bold and daring. I know its been in trend for a few seasons now but that doesn't mean that everyone has the guts to go for it, or they opt for the menswear inspired piece that is still ultra feminine. Fresh faced Chloe Grace Mor... (more...)
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Fixed PriceDelivery by February 26, 2014
I have a 3.40minutes short video in AVI format with the text transcriptions of the Video in ms word docx,
I need a PowerPoint presentation Specialist to help me reproduce this video into a PowerPoint presentation with both pictures and extract out the keywords for each slides (picking out the most important phases –but not word for word from the videos please!!!)
You need to find or create the appropriate pictures that are suitable to express out the main topic/ points of each sub-points.
Once you have extracted out the important points from the original video, you need to Remodel it with ''My Scripts'' which I will provide together in ms word docx format and then create for me a "Simple" yet Compelling and high quality designed professional effective PowerPoint presentation that I could later convert it into a marketing video for the launching of my website.
You can add a little animation and some transitions (but not too much - I don't want it to be overpowering or distracting.) for the time being I don't need the music or voice over.
Compulsory Requirements:
-I prefer full background in white colour, use 70% of the full background
- I want page number to be shown in each page /slide
-Each Main topic and points of each sub-points must appear progressively on the Slides
I am very time crunched which is why I am using this service for this project so please only place a bid if you are confident in your ability to complete the project. I would also happily negotiate a bonus if the project could be completed under my parameter of satisfactions.
The applicants must provide me a valid Gmail address to email over to you the current ''Original Video'' that need to be re-model because the size of the video file is over 5MB which i am not able to attach via odesk but to use google drive to gmail to you.
i have attached ''My Scripts'' in Ms Word docx with this Job Posting, you can study my scripts and have a basic understanding of the Topic of PPT that need to be create.
- I only want the Provider to submit to me the finished job for me in ms PowerPoint Presentation Slides 2007 version – not a higher version or lower version because I am just using the 2007 version PPT - This Must Strictly Follow My Requirement. –
i will be conducting My Interview via Skype with the Team Viewer together to show to the candidate exactly what type of PPT Presentation style I want, if the candidates disagree with my type of interview, please don't apply*
THIS IS QUITE A SIMPLE JOB, IF YOU ARE A PRESENTATION SPECIALIST ! - Top Providers with Great Profiles & Feedbacks are Welcome to offer me your prefered Bid Rates ! TQ.
DeadLine : 27th Feb 2014 Thursday, 2pm (Singapore Time)
Thank You.
About the Client
Selangor 10:00 PM
Jobs Posted
63% Hire Rate, 1 Open Job
Over $10,000
Total Spent
106 Hires, 5 Active
Avg Hourly Rate Paid
363 Hours


text:
Product Details
Style: UC65-505
The hand-crocheted KJUS Largo Burl Beanie is the perfect topper to your ski ensemble. The Largo is lined with fleece for added warmth and extra comfort and the iconic KJUS logo is crocheted in a contrasting color.
- 100% Polyacrylic Yarn knit
- 100% Polyester Fleece lining for extra warmth
- Hand crocheted
- Cozy fleece lining is warm and soft
- KJUS logo in contrasting color
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ASK A QUESTION Got questions about this product? Ask them here. Got questions about anything else? Please see our FAQ.
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text:
Garcia To Mayweather: We'll Take Bet For Everlast MX
By Edward Chaykovsky
Robert Garcia, trainer for Marcos Maidana (35-4, 31KOs), is willing to accept a wager being offered by Floyd Mayweather Jr. (46-0, 26KOs) - but only under one condition. During their five city press tour for the September 13th rematch, Mayweather dared Maidana to bet his entire purse on the fight.
"If he really feels like he won the first fight then he should bet his purse. He should put his money where his mouth is. But he knows he can't beat me," Mayweather said.
Garcia, and Maidana, are willing to take the bet - if Mayweather allows the Argentine puncher to wear his favorite Everlast MX gloves. One day prior to their scheduled meeting on May 3rd, Mayweather refused to go forward with the fight until Maidana agreed to use a different style of gloves by Everlast.
Mayweather rejected two different pairs of Everlast MX gloves, presented by Maidana, because the unbeaten boxer claimed that MX style of gloves have little to no padding around the knuckle area. The Nevada State Athletic Commission saw no issue with the second pair Maidana presented.
"He bet Chino's purse and we responded by saying we'll take the bet if Chino can wear his Mexican Everlast gloves. All I need is a handshake from him, but I know I won't get that," Garcia said.
The contract is signed, everything is set. or are they? whats stopping mayweather from changing something 1 day before the fight. mayweather set the precedence and so until that bell rings, everyone will be deepthroating mayweather to make sure he…Comment by Francis M. on 07-22-2014
Garcia needs to stop. They already signed the contract and obviously their glove of choice cannot be used. Floyd got his way because he's the A side but people will always discredit him because he does these well documented pu$$ay…Comment by LoadedWraps on 07-22-2014
[QUOTE=turnedup;14782017]I think Garcia and company saw something they missed in that first fight and feel really good about implementing into this rematch. I mean it's one thing to hype a fight but he's putting his reputation big time behind this…Comment by Spoon23 on 07-22-2014
To Maidana, stand your ground and die with your own sword. Use your own glove choice not be played again by a coward boxer who is taking away your only advantage. Which is your power. Use your punchers gloves you…Comment by ~BoZz~ on 07-22-2014
Garcia is a known scumbag person who would eat his brothers flesh for a few dollars,every fighter he trains is a bum..rios being the biggest and maidana being the second lol..and don't forget that garcia loves to train cheaters like…Post a Comment - View More User Comments (58)


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fiction. nonfiction. poetry. pop flotsam. cultural jetsam.
Learn More
Bieber gives a public apology, turning his hat forward (to the gasps of the crowd) and saying, "This is me. I'm not a bad guy. I actually love Christ." He reinvents himself in one move.
Bake "Presidential Candidate Pistachio" cookies. Eat two. Give the rest to your students as acts of kindness.
Barrelhouse Magazine
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Conversations and Connections


text:
MMA Forum - UFC Forums - UFC Results - MMA Videos (http://www.mmaforum.com/forumindex.php)
- UFC (http://www.mmaforum.com/ufc/)
- - Your top 10 Lightweight Rankings (http://www.mmaforum.com/ufc/3029-your-top-10-lightweight-rankings.html)
Your top 10 Lightweight Rankings
If you ask me this is the division is one of the strongest the UFC has to offer now. I wouldnt say as strong as the welterweight division but this division has an endless amount of talent.
I dont think there's been a top 10 lightweight thread on this forum so what is your ranking?
1. Sean Sherk
2. Mark Hominick
3. Kenny Florian
4. Joe Stevenson
5. Hermes Franca
6. Yves Edwards
7. Joe Lauzon
8. Spencer Fisher
9. Melvin Guillard
10. Tyson Griffin
Honorable Mentions: Jamie Varner, Jens Pulver, Jorge Gurgel, Duane Ludwig
1. Sean Sherk
2. Kenny Florian
3. Mark Hominick
4. Melvin Guillard
5. Joe Stevenson
6. Hermes Franca
7. Tyson Griffin
8. Spencer Fisher
9. Yves Edwards
10. Jon Fitch
1. Sean Sherk
2. Melvin Guillard
3. Kenny Florian
4. Mark Hominick
5. Joe Stevenson
6. Hermes Franca
7. Tyson Griffin
8. Spencer Fisher
9. Jon Fitch
10. Yves Edwards
Seeing as kenFlo is fighting for the championship he must be 1 or 2.
Fitch will be good chance one day. Pulver will come back. Joe daddy will be tough, Melvin also.
Quite a stacked division that. cant see Sherk losing in a hurry.
1. Sean Sherk
2. Melvin Guillard
3. Kenny Florian
4. Joe Stevenson
5. Hermes Franca
6. Spencer Fisher
7. Tyson Griffin
8. Mark Hominick
9. Yves Edwards
10. Sam Stout
I don't think Ken Flo's Strong enough or has good enough cardio to be #2.
LMFAO....again Jon Fitch is NOT a LW.:thumbsdown:
He's 6ft tall and he's fought Wilson Gouveia (LHW fighter) for crying out loud (lol)....
1) Sherk
2) Stevenson
3) Florian
4) Homminick
5) Franca
6) Guillard
7) Griffin
8) Fisher
9) Yves (although the UFC has released him)
10) Stout
side note: if Penn drops down I will immediately rank him #2 and he would pwn Sherk
if BJ drops down hes #1 for life
I also dont understand why people are ranking Griffin over Hominick, Griffins fight was impressive but he basically fought garbage.
"Yves (although the UFC has released him)"
Why did they release Edwards? He was certainly a good fighter that would have brought a lot to the division.
The UFC released Yves? I thought he was going to be at UFC 64? I sure hope not, Yves is awesome and probably would have beat Stevenson if not for a questionable stoppage.
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text:
Jim Cullum Jr.
In the 1950s when everyone else his age was listening to Elvis Presley and Connie Francis, Jim Cullum locked onto the sounds of early jazz greats Louis Armstrong, Bix Beiderbecke, King Oliver and Jelly Roll Morton. At first he thought he might want to play trombone, but one day while helping his dad in the grocery business, Jim caught sight of an antique cornet in a store window and fell in love.
While attending Trinity University in San Antonio, Jim formed a seven-piece traditional jazz group, the Happy Jazz Band, with his father the late Jim Cullum, Sr., who had played professionally with Jack Teagarden and others in the 1940sRead more
CD/LP/Track Review
- Porgy and Bess Live by Jack Bowers
January 21, 2014
A Triple Crown Of Tunesmiths This Week On Riverwalk Jazz
January 14, 2014
Jim Cullum Jazz Band Live From Stanford This Week On Riverwalk Jazz
November 18, 2013
Whiz Kid Of Swing John Hammond This Week On Riverwalk Jazz
October 29, 2013
This Week On Riverwalk Jazz: Wizard Of Oz With Vernel Bagneris
October 23, 2013
Songwriting Bandleaders Of The Swing Era This Week On Riverwalk Jazz
October 16, 2013
This Week On Riverwalk Jazz: The Great Innovator---benny Goodman
October 07, 2013
This Week On Riverwalk Jazz: Battle Of The Bands With Banu Gibson,...
Bill McFarlin, Executive Director of the International Association of Jazz Educators notes: "The Jim Cullum Jazz Band is one of the nation's premiere ensembles."
Primary Instrument
San Antonio, TX
Clinic/Workshop Information
Jim Cullum and the Jazz Band describe and demonstrate the techniques and theory behind early jazz playing, such as polyphony, or "many voices" improvisation common in the early days of jazz, and how an early jazz rhythm section functions. Each ndividual player demonstrates the role of his instrument in the ensemble, and the band performs selected masterworks from the early jazz repertoire, such as from Louis Armstrong, Jelly Roll Morton, Fats Waller, King Oliver, Sidney Bechet, etc


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Most of what the film does right comes from a combination of homage to past classics with an awareness of what this kind of film needs to do for modern moviegoers. Read More »
Home / Tag Archives: exorcism
Blu-ray Review: Lisa and the Devil/The House of Exorcism – Arrow Video Release
From art to shart - Arrow Video chalks up another win for filmmaker Mario Bava. Read More »
Theatre Review (LA): The Exorcist by John Pielmeier at The Geffen
John Pielmeier delivers a stage version of the famous supernatural tale, with mixed results. Read More »
Blu-ray Review: The Rite
Ultimately hokey, this exorcism tale is at least technically excellent in high definition. Read More »
Movie Review: The Last Exorcism
What awaits the unsuspecting and slightly arrogant Marcus is the stuff nightmares are made of. Read More »


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- 2016
A systematic review and meta-analysis of the effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex in healthy and neuropsychiatric samples: influence of stimulation parameters
2016) BRAIN STIMULATION. 9(4). p.501-517 Mark(
Emotional reactivity to valence-loaded stimuli are related to treatment response of neurocognitive therapy
2016) JOURNAL OF AFFECTIVE DISORDERS. 190. p.443-449 Mark(
- The effect of the interval-between-sessions on prefrontal transcranial direct current stimulation (tDCS) on cognitive outcomes: a systematic review and meta-analysis
- The application of tDCS in psychiatric disorders: a brain imaging view
- 2015
BDNF blood levels after non-invasive brain stimulation interventions in major depressive disorder: a systemic review and meta-analysis
2015) WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. 16(2). p.114-122 Mark(
Neurostimulation as an intervention for treatment resistant depression: from research on mechanisms towards targeted neurocognitive strategies
2015) CLINICAL PSYCHOLOGY REVIEW. 41. p.61-69 Mark(
- The effect of a single HF-rTMS session over the left DLPFC on the physiological stress response as measured by heart rate variability
Combining tDCS and working memory training to down regulate state rumination: a single-session double blind sham-controlled trial
2015) COGNITIVE THERAPY AND RESEARCH. 39(6). p.754-765 Mark(
- Impact of anodal and cathodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex during attention bias modification: an eye-tracking study
- 2014
One left dorsolateral prefrontal cortical HF-rTMS attenuates HPA-system sensitivity to critical feedback in healthy females
2014) NEUROPSYCHOLOGIA. 57. p.112-121 Mark(


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Where the art of joyful dining is yours to discover.
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We offer a variety of wines from John Ernest Vineyards. Purchase a bottle to enjoy with your meal or take a few home to share!
Signature desserts like our White Chocolate Banana Cream Pie & Chocolate Tuxedo Cake are homemade from scratch every day.
The Bread Basket is open Tuesday through Friday
8:00 a.m. to 3:00 p.m. Saturdays and evenings
for private parties by reservations only.


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An at-a-glance version of the Federal guides that help school, district, and higher ed emergency management personnel develop and update high-quality, customized emergency operations plans.
Access Webinar on Friday, August 19 from 1:30-2:30 PM EST with U.S. Department of Education and the Centers for Disease Control and Prevention.
Click here to view the guidance or view it via our infectious diseases page.
Download this document that answers common questions about lead poisoning and exposure in Flint, Michigan.
Share a #SchoolSafetySelfie on Twitter or on our Community of Practice! Add your role in field & tag us on Twitter!
The School Survey on Crime and Safety (SSOCS) is currently in the field collecting data for the 2015-16 school year! Learn more about SSOCS here
A virtual space to collaborate on special projects, share news and resources, discuss trends and ideas, and learn from the experiences of others in the field. Join today!