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Massena: Ricky J. Brainard, "Tyke" 58, formerly of Maple St. passed away from injuries sustained in a motor vehicle accident on Monday August 29, 2016 at The University of Vermont Medical Center, in Burlington, VT. Friends and family may be received... Read More >>
LOWVILLE – Mrs. Velma F. "Weehunk" Kingsley, 104, of 7433 Rice Road and former resident of Parishville, peacefully passed away early Tuesday morning, August 30, 2016 at her home, where she resided with her daughter for the past several years.... Read More >>
MALONE - Heaven gained a precious angel on August 23, 2016 when Linda A. Porter, daughter of the late Clarence and Lucy Dow Porter gained her wings.
There will be a private burial in the North Lawrence Cemetery.
We would like to thank all of Linda's... Read More >>
LISBON-Funeral services for Eva M. McDonald, 88, of Lisbon will be held on Friday, September 2, 2016 at the LaRue & Pitcher Funeral Home at 2 p.m. with Rev. David Norman officiating. Burial will follow in Pine Hill Cemetery, Eel Weir. A... Read More >>
Rochester: Carl E. Girard, 37, passed away on August 28, 2016 at Strong Memorial Hospital in Rochester after a brief illness. There will be no public calling hours. Memorial services for Carl will be held on Saturday, September 3, 2016 at 11:00 a.m... Read More >>
NORWOOD- Elizabeth T. Bancroft, 95, formerly of State Route 56, peacefully passed away Saturday night, August 27, 2016 at United Helpers Maplewood Campus, Canton.
There will be no calling hours. A graveside service will be held at the Crary Mills... Read More >>
NORFOLK— Calling hours for 77 year old James P. "Pat" Shepard, a resident of 77 VanKennen Road, Norfolk, will be held Saturday, September 3, 2016 from 10 a.m. until 12 noon at the Buck Funeral Home in Norwood. Mr. Shepard passed away Saturday at... Read More >>
Memorial Mass for Josephine F. Kingston, 97, of Canton, will be held on Wednesday, August 31, 2016 at 10:00 a.m. at St. Mary's Church, Canton, with Rev. Douglas J. Lucia, celebrating. Burial will follow in Bayside Cemetery in Potsdam. Josephine died... Read More >>
A memorial mass to celebrate the life of Sylvia J. Bouck will take place at 11 a.m. Sept. 3, 2016 at St. Patricks Catholic Church in Colton. All are welcome.
Sylvia Jane Bouck, 87, passed away Feb. 29, 2016, in Melbourne, Fl.
Sylvia was born Oct.... Read More >>
A memorial mass for Josephine F. Kingston, 97, of Canton, will be held on Wednesday, August 31, 2016 at 10:00 a.m. at the St. Mary's Church, Canton, with Rev. Douglas J. Lucia, celebrating.
Josephine passed away on Saturday, August 27, 2016 at the... Read More >>
Funeral services for Lawrence E. LaPoint Sr., 90, of Russell, will be held on Thursday, September 1, 2016 at 10:00 a.m. at the O'Leary Funeral Home, Canton, with Anne Davis-Harmer, officiating. Burial will follow in the Hermon Cemetery. Lawrence... Read More >>
Arrangements for 77-year-old James "Pat" Shepard, a resident of 77 VanKennen Road, Norfolk, are incomplete at this time with the Buck Funeral Home.
Mr. Shepard passed away Saturday afternoon at the Canton-Potsdam Hospital. A complete obituary will... Read More >>
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MMA Forum - UFC Forums - UFC Results - MMA Videos (http://www.mmaforum.com/forumindex.php)
- UFC (http://www.mmaforum.com/ufc/)
- - No weight classes: Silva v. Liddell (http://www.mmaforum.com/ufc/3971-no-weight-classes-silva-v-liddell.html)
No weight classes: Silva v. Liddell
Let's pretend this were the old UFC and there are no weight classes, who wins in A. Silva vs. Chuck?
We could say that Silva could put on a few pounds, but I'm not sure how that may or may not disrupt his speed, anyone know how tall the 2 fighters are and how their reach would compare?
I know Liddell is the "god" of the ufc and all, but I wonder how he'd fair against the speed/precision of a striker like Silva?
I would put my money on Silva, he just seems so fast and technical!
Liddell would win this one. As great as Silva is and as precise a striker he is, Chuck has a knack for counter punching at the right angle at the right time and hittin the button everytime. We all know Chuck probably hits harder or as hard as anyone. He has that 1 punch fight changer. Lets not forget Liddell is a world class kickboxer himself. It would start kind of slow because both would be cautious of the others striking ability. Id say Liddell 3rd round KO.
I'd bet everything on lidell. He's got the advantage standing and he won't be stupid enough to invite a clinch.
Andersons more precise but Chucks a much power powerful striker. Chuck would evitally catch him. As a counter puncher Chuck matches up with Silva better than Rich did. Richs strength lies with chasing people around and being the superior striker which he is not against Silva. With Chuck it doesnt matter. ANd he wouldnt get outmuscled like franklin did.
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Dental Crowns Center - Mishawaka, IN
- WebMD Physician Directory of Mishawaka Doctors
- Related Dental Crowns Articles
- Mishawaka Emergency Contacts
- Nearby Mishawaka Hospitals
- Find a Local Pharmacy on RxList - Mishawaka
Mishawaka Doctors and Specialists for Dental Crowns
Dental Crowns
What is a dental crown?
The anatomy of a tooth can be divided into two basic parts -- the root and the crown. In a person with healthy gums and bone, the root of the tooth is covered by the gums and bone. The part of the tooth that is vi...
Other Related Dental Crowns Articles
Emergency Contact for Mishawaka
- In case of Emergency, call 911
Nearby Mishawaka Hospitals results
- 1Kindred Hospital
215 W 4th St
Mishawaka, Indiana 46544
(574) 252-205
- 2Memorial Epworth
420 N Niles Ave
Mishawaka, Indiana 46617
(574) 647-100
- 3Memorial Hospital Of South Bend
615 N Michigan St
Mishawaka, Indiana 46601
(574) 647-100
- 4Saint Joseph Regional Med Ctr
5215 Holy Cross Pkwy
Mishawaka, Indiana 46545
(574) 335-500
- 5Healthwin Specialized Care
20531 Darden Rd
Mishawaka, Indiana 46637
(574) 272-010
- 6Elkhart General Hospital
600 East Blvd
Mishawaka, Indiana 46514
(574) 294-262
- 7Community Hospital Of Bremen
1020 High Rd
Mishawaka, Indiana 46506
(574) 546-221
- 8Lakeland Community Hospital
31 N Saint Joseph Ave
Mishawaka, Indiana 49120
(269) 683-551
- 9Oaklawn Hospital
330 Lakeview Dr
Mishawaka, Indiana 46528
(574) 533-123
- 10IU Health Goshen Hospital
200 High Park Ave
Mishawaka, Indiana 46526
(574) 533-214
- 11Lakeland Specialty Hospital
6418 Deans Hill Rd
Mishawaka, Indiana 49102
(269) 471-776
- 12Michiana Behavioral Health
1800 N Oak Dr
Mishawaka, Indiana 46563
(574) 936-378
- 13Borgess Lee Memorial Hospital
420 W High St
Mishawaka, Indiana 49047
(269) 782-868
- 14St Joseph Regional Medical Ctr
1915 Lake Ave
Mishawaka, Indiana 46563
(574) 936-318
- 15Indiana University La Porte
1007 Lincolnway
Mishawaka, Indiana 46350
(219) 326-123
- 16Three Rivers Health
701 S Health Pkwy
Mishawaka, Indiana 49093
(269) 278-114
- 17Lakeland Healthcare
1234 Napier Ave
Mishawaka, Indiana 49085
(269) 983-830
- 18Lakeland Community Hsptl Wtrvlt
400 Medical Park Dr
Mishawaka, Indiana 49098
(269) 463-311
- 19Kosciusko Community Hospital
2101 Dubois Dr
Mishawaka, Indiana 46580
(574) 267-320
- 20Bowen Center For Human Services
850 N Harrison St
Mishawaka, Indiana 46580
(800) 686-684
- 21IU Health Starke Hospital
102 E Culver Rd
Mishawaka, Indiana 46534
(574) 772-623
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Monte Pittman
To hear 'Inverted Grasp of Balance' (due out this Friday, September 23rd) in full before its release, please visit the Wall Street Journal - where an exclusive interview with Monte Pittman can be read, alongside the album stream!Read More
Charred Walls of the Damned
Today, Charred Walls Of The Damned's album Creatures Watching Over The Dead is available as an exclusive stream in advance of the release on HowardStern.com. Check out the new record in its entirety.Read More
Downfall of Gaia
On November, 11th Downfall of Gaia will release their sophomore album, 'Atrophy', via Metal Blade. For a first preview of 'Atrophy' surf over to metalblade.com/downfallofgaia where you can stream the 1st single 'Woe'.Read More
New Releases
New Releases
Latest News
REVOCATION announces European tour with Obscura and Rivers Of Nihil!
- 22/06/16 – One month before the official release of...Read More
DENNER / SHERMANN launches trailer for upcoming video, 'Son of Satan'!
- 15/06/16 – The trailer for the long-awaited music video, 'Son...Read More
ENTRAILS announces a dozen of Death Metal shows for the summer and fall!
- 15/06/16 – Swedish Death Metallers ENTRAILS have just announced a...Read More
CATTLE DECAPITATION announces 'European Extinction Tour 2016′ part II!
- 14/06/16 – Part I to kick off this weekend at Hellfest! Only a few...Read More
WHITECHAPEL streams new album, 'Mark of the Blade', via VansWarpedTour.com
- 13/06/16 – Launches social media takeover of Vans Warped Tour...Read More
KETZER to release official bootleg videoclips for 'When Milk Runs Dry' and 'Starless'!
- 13/06/16 – German extreme metallers KETZER have returned from their...Read More
REVOCATION premieres lyric video for 'Monolithic Ignorance' via Stereogum.com!
- 09/06/16 – Having delivered five killer albums boasting some of the...Read More
HAMMERS OF MISFORTUNE reveals details for new album, 'Dead Revolution'
- 09/06/16 – Launches title track online! On July 22nd, West Coast...Read More


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Marks & Morgan Jewelers telephone number is (864) 234-0038.
Telefax: No fax number available
Website: No web address available
Biz owner? Moderate reviews or edit listing.
Search entire category for Jewelers
Jewelers are skilled individuals in Greenville, who design & manufacture various forms of jewelries based on different materials and sell those either directly to customers or to merchants. Precision is essential in this profession.
Alliance for Green Heat and NYSERDA Announce Seven Finalists in International Pellet Stove Competition
Two New York teams are among the finalists (Long Island, NY) Alliance for Green Heat and the New York State Energy Research and Development Authority (NYSERDA) today announced that seven pellet stoves have been chosen as finalists in the Pellet Stove Design Challenge. This international competition, administered by the Alliance for Green Heat, identifies innovative low emissions and high efficiency..


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As one of Takuto's real life school friends, Futaba is completely unaware of his magical powers. Flirty and very girly, she has a crush on her close school friend and is utterly horrified if he is associated with any other females.
|Magician's Academy
jp. Rina SATOU
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MSA Coalition Research Grants – Funded Projects
Listed below are the research projects funded by The Multiple System Atrophy Coalition as part of the MSA Research Grant Program. The below projects were selected from many applications after bing reviewed and ranked by The MSA Coalition's Scientific Advisory Board (SAB). These projects are deemed to have strong scientific merit toward accomplishing The MSA Coalition's primary mission of identifying a cause and a cure for MSA.
2015 MSA Research Grant Award Recipients:
"Global MSA Registry & Natural History Study – Year 2": Gregor Wenning, M.D, Ph.D. (Innsbruck Medical University) and Lucy Norcliffe-Kaufmann, Ph.D. (New York University)
This project aims to establish the first-ever global registry dedicated to Multiple System Atrophy patients. Facilitating future worldwide clinical trials, the registry will be used to notify all patients that meet study entry criteria for clinical trials in MSA on an international scale. The registry will also provide a means for sharing anonymous patient information to define the disease specific characteristics and establish the definitive natural history of MSA. Registered patients will be followed thoroughly and periodically to identify potential biological markers of disease risk and severity in a global, worldwide longitudinal prospective study.
"Combination of immunotherapy against alpha-synuclein and anti-inflammatory treatment for Multiple System Atrophy": Eliezer Masliah, M.D. (University of California San Diego)
Multiple system atrophy (MSA) is a rare and devastating neurological disease that impairs body functions and that shares many Parkinson's disease symptoms. Sadly, there is no treatment that stops the evolution of MSA and current therapies are focused on managing its symptoms. At the molecular level, MSA is characterized by the abnormal accumulation of the protein alpha-synuclein within brain cells, and it is believed that this accumulation is behind the cell death and inflammation observed in the brain. Therefore, our objective is to explore the potential use of the combination of two therapies in order to restore normal alpha-synuclein and inflammation levels. These therapies are immunization against alpha-synuclein, in order to reduce its levels, together with the use of a potent anti-inflammatory drug, lenalidomide, aimed to reduce pathological brain inflammation. We believe that the combined use of both therapies will have synergistic protective effects in an animal model of MSA, and that such approach could be applied to the treatment of MSA patients.
"Understanding the degradation of alpha-synuclein protein in MSA": Janice Holton, M.D, Ph.D. (University College of London)
In multiple system atrophy (MSA) a protein called αlpha-synuclein sticks together in oligodendrocytes to form glial cytoplasmic inclusions (GCIs). Oligodendrocytes are specialized brain cells that are crucial for supporting neurons. There is no increase in the production of αlpha-synuclein in MSA, so we believe that the breakdown of αlpha-synuclein from the brain may not be working properly. We will look at 2 substances, known as proteases, called cathepsin D (CTSD) and kallikrein 6 (KLK6), which breakdown αlpha-synuclein. CTSD and KLK6 are particularly relevant to MSA because they are found in neurons, oligodendrocytes and inside GCIs. Alpha-synuclein also clumps together in Parkinson's disease (PD) where nerve cells are the main target. CTSD and KLK6 may have reduced activity in PD contributing to the accumulation of αlpha-synuclein in neurons and damaging them. This strongly suggests a role for dysfunction of CTSD and KLK6 in MSA. We will analyze the activity of CTSD and KLK6 in 10 regions of 20 MSA and 20 control brains and determine how this relates to the number of GCIs. Next we will grow oligodendrocytes and control their levels of CTSD and KLK6 to see if we can improve the breakdown of αlpha-synuclein. As the first study to examine proteases in MSA we will improve understanding of αlpha-synuclein breakdown and help to find new avenues for research and potential treatments.
"Gene expression & methylation as a route to MSA biomarkers and drug targets": Henry Houlden, Ph.D. (University College of London)
Multiple system atrophy (MSA) is a neurodegenerative disorder with an overall prevalence of 2-4/100,000 people. MSA is characterized by abnormal movements (parkinsonism), unsteadiness (ataxia) as well as alterations in blood pressure control and urinary problems (autonomic failure). In the initial stages of the disease, MSA can be difficult to distinguish from Parkinson's disease and some forms of ataxia. However, MSA has additional clinical features and an aggressive progression, with an average time to death being 8-9 years. The brain of MSA patients presents accumulation of a protein called alpha-synuclein, and loss of neurons in specific regions of the brain. The causes of MSA are largely unknown. There are small families with this condition but the majority of cases are not known to be inherited from generation to generation (sporadic disease). An increased risk of MSA has been proposed as associated with variations in certain genes – SNCA and COQ2. This study aims to investigate how genes make products that are needed for cells, and which variations those products show that can be related to the disease. This will eventually identify candidate genes and measurable indicators (biomarkers) of the disease, and reveal target pathways for therapeutic intervention.
"Glucagon like peptide-1 agonists for treating MSA: a preclinical POC study": Wassilios Meissner, M.D, Ph.D. (University of Bordeaux)
Developing neuroprotective and disease-modifying treatments for multiple system atrophy (MSA) is an urgent unmet need. As of late, interest has been given to insulin and insulin like growth factor-1 (IGF-1) in the neurodegenerative disorder field as both mediate numerous pro-survival actions through their brain receptors. Studies in animal models and postmortem human brain tissue of patients suffering from Alzheimer's disease (AD) and Parkinson's disease (PD) have found impaired insulin/IGF-1 signaling and insulin resistance. Moreover, several FDA-approved anti-diabetics have shown positive effects on behavior and surrogate markers of neurodegeneration in preclinical models of AD and PD. These encouraging findings have motivated the conduction of several pilot studies in patients with AD and PD. In this view, a clinical trial assessing the effects of the glucagon-like peptide-1 agonist exendin-4 in PD patients reported beneficial effects on motor symptoms and cognition. A follow up study showed persisting positive effects one year after the end of the study. Interestingly, patients with multiple system atrophy (MSA) show a significant increase in insulin/IGF-1 serum levels suggesting that insulin/IGF-1 signaling may also be impaired in MSA. Our preliminary findings in postmortem brain tissue of MSA patients suggest impaired insulin/IGF-1 signaling and brain insulin resistance. This study aims at assessing the effects of exendin-4 on motor symptoms and surrogate markers of neurodegeneration in a transgenic mouse model of MSA. In case of positive results, our ultimate goal is to test this compound in MSA patients, in line with our major objective to develop disease-modifying or neuroprotective treatments for MSA.
"Defining diagnostic brain MRI markers in early MSA with a novel toolbox": Florian Krismer, M.D. (Innsbruck Medical University)
Multiple system atrophy (MSA) is a rare and devastating neurological condition. There is currently no therapy that can halt or slow the progression of the disease. Clinical trials with a large number of patients are required to test the efficacy of candidate agents. One of the prerequisites of clinical trials is that the patients enrolled in them should be as homogeneous as possible. In addition, potential treatments should be applied as early as possible. Hence, an early and reliable diagnosis of MSA is critical. However, it is difficult to discriminate different parkinsonian disorders at very early disease stages on clinical symptoms only. Thus, for the purpose of patient counseling and clinical research, additional investigations are inevitable. Based on emerging findings in favor of specific sequences of brain magnetic resonance imaging (MRI) as early diagnostic markers of MSA pathology, we propose to develop a MRI toolbox that consistently separates MSA from other degenerative parkinsonian disorders.
"Preclinical Evaluation of Novel Therapeutic for MSA": Ruth Perez, Ph.D. (Texas Tech University Health Sciences Center)
Multiple system atrophy (MSA) is a rapidly progressing brain disease with no treatment or cure. My laboratory is studying an FDA-approved drug that is used worldwide to treat patients with multiple sclerosis, a brain disorder that like MSA damages the myelinating cells of the brain. MSA, like MS, tends to strike a younger
population than those who develop a more common movement disorder Parkinson's disease (PD). MSA and PD have limited overlapping pathology and symptoms, and both may benefit by treatments that protect the brain's signaling and support cells. In this grant, we will test an FDA-approved drug and two new compounds based on the FDA-approved drug in animal and cellular models of MSA. This will allow us to assess their ability to protect both the signaling neurons and the supporting myelinating cells. If data from this preclinical assessment are supportive, the FDA-approved drug can be rapidly repurposed for MSA, providing the first therapy that may slow disease progression and improve the quality of life.
"Detection of pathological alpha-synuclein aggregates in CSF by qRT-QuIC": Armin Giese, M.D. (Ludwig-Maximilians-University Munich)
Reliable molecular biomarkers for early diagnosis and monitoring the disease progression in MSA are urgently needed, but are lacking to date. Deposits of aggregated alpha-synuclein (aSyn) are the pathological hallmark of MSA. However, reliable tools for the quantification of pathological aSyn in body fluids such as cerebrospinal fluid (CSF) are currently missing. We have established a rapid and reliable tool, qRT-QuIC (quantitative real-time quaking-induced conversion), to be able to sensitively and specifically detect and quantify even minute amounts of pathological protein aggregates, which we now want to apply to CSF samples of MSA patients.
(1) We will optimize the existing assay to detect pathological aSyn aggregates with high accuracy: This requires the adjustment of the assay conditions and its subsequent testing using recombinant and brain derived pathological aggregates as seeds.
(2) In a second step, validation of the assay will be carried out by analyzing patient CSF-samples from MSA patients (n=50), PD patients (n=50), and controls (n=100) including an independent cohort validation.
(3) Finally, we will further standardize and automate the assay resulting in a routine method for clinical diagnostics.
The results of this study will be of crucial importance to find a reliable biomarker for MSA. If successful, this method would allow for precise early diagnosis and could be a powerful tool to track disease progression and to monitor therapeutic effects of novel therapeutics in MSA as well as in other synucleinopathies.
"Targeting alpha-synuclein pathology with the molecular tweezer CLR01 in MSA ": Nadia Stefanova, M.D, Ph.D. (Innsbruck Medical University)
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that currently lacks efficient therapy. We will test a novel drug candidate that blocks formation of toxic αlpha-synuclein aggregates, which are believed to have causative role in the pathogenesis of MSA. The drug has shown promising results in preclinical models of Alzheimer's and Parkinson's disease. As a necessary step towards human clinical trials, we will now test the drug in a pre-clinical model of MSA. The project has the goal to test the ability of the new drug to prevent and/or reverse the formation of the αlpha-synuclein aggregates that are believed to play a major role in the disease process of MSA. The mouse studies will be conducted in collaboration between the Stefanova laboratory at the Medical University of Innsbruck, Austria and the Bitan laboratory at UCLA using a well-established pre-clinical model of MSA which reproduces the specific pathology of this disorder in the mouse brain. These studies will establish the dose-dependent effects of the drug and its efficacy in MSA-like neurodegeneration. The data of this proof-of-concept study will be followed by behavioral studies and thorough characterization of neuroprotection effects generating a preclinical rationale for a future interventional trial in MSA.
"Mechanisms of Selective Neuronal Death in MSA: Focus on blood pressure controlling areas ": Eduardo Benarroch, M.D. (Mayo Clinic Rochester)
Despite extensive research in multiple system atrophy (MSA), the cause of death of neurons (nerve cells) controlling movement, blood pressure and other functions is yet unknown. Neuronal death may be due to their abnormal interaction with oligodendrocytes, the cells that produce myelin and provide nutrition to the neuronal portion called axons. Some neurons are affected early in the disease, but what makes these neurons vulnerable is still uncertain. Both neurons and oligodendrocytes accumulate the protein αlpha-synuclein (α-SYN), and this abnormal accumulation may propagate along connections between neurons. Therefore, it is important to determine what causes neuronal loss and whether this propagates along vulnerable pathways. Over the past several years we have studied brain areas controlling blood pressure in MSA, since a fall of blood pressure during standing (called orthostatic hypotension) is one of the most disabling MSA symptoms. We found that loss of one group of neurons controlling blood pressure is associated with α-SYN accumulation in surrounding oligodendrocytes and indices of abnormal iron metabolism. We hypothesize that there is a reciprocal interaction between neurons and oligodendrocytes leading to loss of both types of cells, including abnormal iron metabolism and nutrient deprivation. We plan to study four different brain areas controlling blood pressure; two containing cells that are potentially more vulnerable and two that may be more resistant but share similar connections. We will combine techniques to identify these neurons, and relate the severity of their loss with that of accumulation of α-SYN in surrounding oligodendrocytes, markers of iron metabolism, and nutrient transfer. The identification of the cause and interactions that make some neurons selectively vulnerable may help to develop treatments that protect vulnerable neurons and slow disease progression.
2014 MSA Research Grant Award Recipients:
"Global MSA Registry & Study Group": Florian Krismer, M.D. (Innsbruck Medical University) and Lucy Norcliffe-Kaufmann, Ph.D. (New York University)
This project aims to establish the first-ever global registry dedicated to Multiple System Atrophy patients. Facilitating future worldwide clinical trials, the registry will be used to notify all patients that meet study entry criteria for clinical trials in MSA on an international scale. The registry will also provide a means for sharing anonymous patient information to define the disease specific characteristics and establish the definitive natural history of MSA. Registered patients will be followed thoroughly and periodically to identify potential biological markers of disease risk and severity in a global, worldwide longitudinal prospective study.
"Stem cell-based Therapeutics Platform for MSA": Vikram Khurana, M.D, Ph.D. (Massachusetts General Hospital)
This project aims to develop new models of Multiple System Atrophy by utilizing stem cell technology to generate human patient-derived stem cell models of the disease. This will enable the study of the biology of an individual patient's disease in the dish by creating their neurons and oligodendrocytes and then looking for signatures of alpha-synuclein toxicity. If alpha-synuclein toxicity signatures are identified it will further assess whether it's possible to reverse this toxicity with genes and small molecules. This work may lead to a new way of testing and discovering potential therapies for MSA beyond the current mouse models of the disease.
Research Update (December 2015):
It is now possible to convert cells from our patients (like blood or skin cells) into embryonic-like stem cells that can be coaxed into forming cells from complex tissue like the human brain. So, for the first time in history we can take, say, a skin cell from a patient with MSA and make that same patient's brain cells in the dish. Just a few years ago no one would have dreamed this was possible – to get brain cells from patients we had to wait until after death. The stem cell-based approach allows us to study in the lab the abnormalities associated with a living patient's disease in the lab, and find ways to reverse it.
The MSA Coalition seed grant allowed me to build on my existing work in Parkinson's disease to create stem cell models from my patients with MSA. We have started to identify abnormalities in these cells and to test potential therapies that can reverse them. We have a long way to go before these findings in the dish reach the clinic, but, thanks to the MSA Coalition, we have made a good start. For a disease like MSA – where there are no clear gene mutations – it is vital that we collect more stem cell lines from patients, and we are beginning to do that. We have high hopes to generate a national stem cell bank for the disease that will provide a critical research tool for the MSA research community and speed up the tempo of drug discovery for this devastating disorder.
"Mechanisms of Excessive Daytime Sleepiness and Sleep Related Respiratory Dysfunction in MSA": Eduardo Benarroch, M.D. (Mayo Clinic Rochester)
Excessive daytime sleepiness and sleep related respiratory disorders such as sleep apnea and laryngeal stridor are prominent symptoms in patients with Multiple System Atrophy. This study aims to uncover the underlying mechanisms of these sleep disorders through pathological studies. Understanding the underlying causes of sleep disorders associated with MSA can provide rationale for development of pharmacological approaches for treatment of these conditions. This can potentially lead both to improvement of quality of life and prevention of premature death in MSA patients.
"Peripheral delivery of brain-targeted neurosin as a novel treatment for MSA": Eliezer Masliah, M.D. (University of California San Diego)
Recent studies suggest that abnormal accumulation of the protein alpha-synuclein in brain cells leads to cellular dysfunctional and neurodegeneration in Multiple System Atrophy and it is increasingly evident that the toxicity of extracellular alpha-synuclein might be related to its ability to be taken up by neighboring cells and act in a prion-like manner. This behavior could be a key event in the origin and progression of the disease.
Compounds that reduce intracellular alpha-synuclein aggregation have received significant attention in recent years but the possibility of reducing the spread of alpha-synuclein from cell to cell by degrading extracellular alpha-synuclein has not been explored in such depth. This project aims to increase the brain levels of an extracellular alpha-synuclein degrading enzyme in mouse models of MSA by means of peripheral gene therapy and targeted delivery to the central nervous system (CNS). Delivery of brain targeted neurosin into the CNS might represent a potential therapeutic option for neurodegenerative disorders including Multiple System Atrophy.
"Biomarker Development in MSA": Roy Freeman, M.D. (Beth Israel Deaconess Medical Center)
There is currently an unmet need for a biomarker in Multiple System Atrophy. A reliable biomarker could contribute to the diagnosis, treatment and disease modification of MSA by improving diagnostic accuracy, defining disease progression and providing an objective measure of the response to disease modifying interventions.
Successful development of a biomarker for MSA would therefore assist in the evaluation and enhance the efficacy of drugs or other interventions that have neuroprotective qualities and offer the possibility of slowing, halting or reversing the rapid progression of MSA.
This study in human subjects, will determine whether alpha-synuclein deposits in cutaneous autonomic nerves is a valid biomarker for multiple system atrophy.


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Donald Penn To Meet With Raiders
Adam Schefter of ESPN reported that Donald Penn was on a plane to Oakland on Thursday night to meet with the Raiders. Penn?s pass blocking slipped in 2012, but he?s been a productive tackle for a long time and would be a good fit for a Raiders team that let Jared Veldheer walk away while they were briefly signing Saffold to the roster.
For more on this story visit: Josh Alper, NBC Sports Pro Football Talk


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Collate 50,000 agents numbers from Propertyguru website (SG)
This project was awarded to amalkeysl for $30 SGD.Get free quotes for a project like this
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Project Budget$30 - $250 SGD
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Project Description
We would like someone to help collate a list of 50,000 agents' mobile numbers from the Singapore Property Guru website. Some examples can be found below.
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Numbers have to be listed in excel format, preferably alongside the names of the agents. A way to crawl the data instead of manual collation would be preferred (to minimize human errors). Data will be randomly audited.
Payment milestones:
10% payment on confirmation of project
40% payment after 1st 30,000 numbers are delivered.
40% payment after next 20,000 numbers are delivered
20% payment after random audit is completed (there must be less than 2% error in the data)
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Everyone acknowledges that gays have served and are serving today in the Armed Services. The fact that they have had to keep their sexual preferences to themselves made the difference - i.e. two gay male soldiers serving in close proximity with each other - who might even find themselves attracted to each other - would likely not even know that the other is gay, so nothing would happen between them.
But now they will know that the other guy is on the "team", so to speak. And then things would change. The idea that a new change in rules will not lead to a change in behavior is one of the reasons liberals are always shocked by unintended consequences, from welfare to tax hikes.
Where the rubber will meet the road is when the armed services are forced to deal with gay servicemen and women in the same unit and/or command chain entering into relationships with each other. This is not just a gay thing - notwithstanding rules against sexual relationships, females are quartered separately from males precisely to prevent this from happening. This is not going to be possible where homosexuals are concerned.
I'm very curious to see the policies the different armed services are going to come up with to deal with the issues that are going to come up. i.e. If (male) SGT A and (male) CPL B serving in the same unit are discovered to be an "item", how should that be dealt with? Should it just be allowed? Should they be separated - SGT A or CPL B moved to another unit - with all the chaos that would entail? Punished? Discharged?
Here's a prediction; there's going to be a jump in the number of disciplinary actions with regard to improper social relationships between grades i.e. "fraternization", and gay servicemen and women are going to be in the dock in numbers far exceeding their proportions in the armed services.
Two possible outcomes;
Mindful of the politics, someone in the Pentagon (civilian or military) is going to advocate turning a blind eye to it. At which point, cases of heterosexual fraternization are going to go up - I simply don't see how CPT Alan and SGT Alice are going to stand for being drummed out of the Army for being a couple when CPT Matt and SGT Mike are walking around holding hands on base.
The other outcome is that the military come down hard and politics would again come into play. The New York Times would eventually notice that 70% of the fraternization cases brought to court-martial involve gay servicemen and women. This would be taken as prima facie evidence of homophobia and discrimination and it would be all over the news.
Liberals are going to react the way they have always have - demand a change in the rules. e.g. African American kids failing math tests? The Conservative would say get better teachers and spend more class time on math. The liberal would call the test racist and demand that it be eliminated because it "discriminates" against African American kids.
Likewise, gay activists are going to launch a new campaign to force the military to drastically soften or eliminate the rules and regulations against fraternization because it "discriminates" against homosexual sailors, soldiers, Marines and airmen.


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6 posts tagged with fault.
Displaying 1 through 6 of 6. Subscribe:
Slip, sliding along
The Town That Creep Built
In Hollister, Calif., fault creep shows that no matter what we create the earth will keep on doing what it wants. If we're lucky, our concrete will serve to mark the changes we cannot stop.
In Hollister, Calif., fault creep shows that no matter what we create the earth will keep on doing what it wants. If we're lucky, our concrete will serve to mark the changes we cannot stop.
The Science Of The Cascadia Fault Earthquakes
Those who may have seen articles such as this Discover Magazine article, may want to know more about the Cascadia fault and the possibility of a Fukushima type earthquake [previously: here]. Here is the best summary of the science that led to the discovery of the 1700 earthquake and the history of earlier quakes. Of particular interest is a beautiful piece of data display in Figure 9 that shows the spacing in time and extent of earthquakes over the last 10,000 years based on evidence of tsunamis produced by the quakes. Finally, here is a great pieces on Surviving a Tsunami should the need arise.
Faultline Flash Game
(Late) Friday Flash Fun: Faultline is a clever platformer where you can fold parts of the level to advance.
It's all their fault. But what can we do about it!
After possibly inspiring Nathan Barley with his Shoreditch Tw*t magazine, editing a semi-iconic lifestyle mag and then burning all his worldly branded goods, Neil Boorman has turned his brain to Baby Boomers and their relation to the current woes of the world. There's a website too...
End Disposable Marriage
Leah Ward Sears, former Chief Justice of the Georgia Supreme Court, on the destruction of fatherhood in Western society. This may sound like heresy, but I believe the United States and a host of Western democracies are engaged in an unintended campaign to diminish the importance of marriage and fatherhood. By refusing to do everything we can to stem the rising rate of divorce and unwed childbearing, our country often isolates fathers (and sometimes mothers) from their children and their families.
What happens when the Big One hits?
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Infinity Ward (the studio behind the enormously successful Modern Warfare 2) just can't seem to stay out of the news these days. Back in late 2009, it seemed like the developer was in the game industry headlines every week--not always with good news, either. Robert Bowling, the man who acts as IW's conduit for the general public, sent shockwaves through the PC gaming community when, shortly before MW2's November release, he revealed that the PC version of the game would be using the new IWnet service for online matchmaking. Using IWnet meant removing support for things like clans, custom maps, and dedicated servers. When the game did come out (and believe me, people still bought it, even the enraged PC boycotters), it was criticized for balance issues (double shotgun guy) and bugs/exploits (more than I can quickly list here). Of course, despite all of this negative press, the folks at IW could still easily hold their heads high because they had just made a game that was critically well-received and had almost unbelievable sales figures. In a word, they were untouchable.
...or so they thought. The dust is still settling, but at least the heads seem to have stopped rolling over at the Infinity Ward studio, and the end result seems to be that Activision (IW's owner and publisher) forcibly dismissed the studio heads and handed the lucrative Modern Warfare franchise reins over to a newly formed studio (no, not Treyarch; they make the other, other Call of Duty games).
Wait, what?
I'm no financial analyst, but if there was one development studio that seemed safe from the executioner's axe, my money was on Infinity Ward. I'm not going to list all the details that have been gleaned from the situation thus far; 1UP's developing story is a much better source, so I'll leave that to them. What fascinates me about this whole debacle is the ambiguity of the business ethics involved. On the surface, this episode looks like just another example of the evil Activision empire tightening its death grip on its developers and putting honest, talented people out of work. It's easy to write the incident off in this fashion--tempting, even. It's no secret that Bobby Kotick (outspoken Activision CEO) is one of the least-liked personalities in the industry, and the fact that the man seems to revel in his infamy lets angry gamers put a (despised) face on the already increasingly unpopular megapublisher.
But what really happened here? It's entirely possible that Activision felt the studio heads at Infinity Ward were getting too big for their proverbial britches and made an example of them. No one is untouchable, etc... On the other hand, rumors have suggested that IW studio heads were in talks with rival publishers. Activision claims they were insubordinate and in breach of their contracts. There's been friction between the publisher and developer for some time, apparently; I guess things finally came to a head, and Activision snapped and unleashed an earthquake. My question is: who made the first move? Was Infinity Ward, flush from the success of MW2 and obviously resentful of their ties to Activision, actively looking for work with competitors? Or was the studio really the latest victim of Activision's ruthless business strategy?
This story also casts the events leading up to and following the release of MW2 in a new light. As I mentioned earlier, IW took some heat for making unpopular choices with the PC version of the game; were those really IW's choices, or did Activision exert pressure on the developer and force those decisions on them? I'd be very interested to know just how involved Activision was in the development of MW2.
If nothing else, this incident serves as an important lesson about publisher-developer relations. It's not uncommon for a developer to be acquired by a giant publisher, gaining the resources to make the epic game they always wanted to, and achieve success beyond all expectations, and then resent their owners after they no longer feel that they need them. Sometimes these situations can be resolved amicably, as in the case of Microsoft and Bungie. Both sides negotiated and worked out a deal where Microsoft could still benefit from Bungie's development and Halo IP, and after a few more years of what is basically indentured service, Bungie would be free to pursue work with other publishers. Neither side probably got exactly what they wanted, but that's compromise for you. I would guess that a similar situation occurred between Activision and Infinity Ward, but without the (comparatively) happy ending. What do you think happened?


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Three splash screens designed with 100% original content as part of my Swinburne University studies in Communication Design.
Projects with a focus on typography, including letterforms made out of mouldy bread and posters of typographical history and quotes.
A packaging project for Swinburne University, including a Design Rationale, focusing on accessibility and legibility in toy packaging for bubble wands.
A variety of marketing materials, advertising and web projects created for Grand Foods (Kahvecioglu), a Turkish food importer in Campbellfield.
Catalogue, photography, logo, manuals and flyers for Australian AGMAX tractor implements under the Sota Tractors umbrella.
A collection of miscellaneous print projects created for various clients, past and present.
Web design and photography for Allendale Kennels, a family run cat and dog boarding kennels in Warrandyte.
Sales brochures, promotional items, marketing materials, photography and website for Sota Tractors.
Wordpress website and photography for Green Kids Early Learning (GKEL) – an 80 place childcare centre in Hampton.
Newspaper advertising designed at Fairfax Community Network for 41 mastheads, including The Melbourne Times, The City Weekly and Victorian Lifestyle magazine.
Websites, digital illustration and more for the College of Lactation Consultants Victoria (CLC-VIC), a professional industry body providing lactation education for practicing LCs and health professionals.
Two websites, signage and photography for Barry Beckett Children's Centre, a community based long day care centre in Coburg.
Facebook campaigns, blogging and engagement for Kaiser Baas, a major brand in electronic gadgets.
A variety of digital illustrations and projects created for clients past and present.


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Steve Troughton-Smith, a well-known iOS developer and hacker, discovered that HeadBoard, the tvOS UI, has "pretty complete" folder support inside. According to him, folders in tvOS work just like those in iOS – you drop an app on another app to create a folder. The folder takes the most likely category name from the apps inside but it's also possible to give it a different name.
Looks like Apple has temporarily turned on streaming of purchased TV shows on the Apple TV for customers in the UK, Canada and Australia on Wednesday. Users from these countries have been able to purchase the episodes directly on Apple TV 2 and stream it to the device. These were actual purchases, not rentals, and cost between free and $2.49 in Canada and about $2.99 AUD in Australia. According to GigaOM, only Aardman Studios, A&E, History Channel, PBS, PBS Kids, Vivendi Entertainment and Viz Media appear to have made their content available as of yet.
Back in October, 9to5Mac found an evidence for a next-generation Apple TV being in the works – a reference to 'Apple TV 3,1' (current model is listed as 2,1) inside the iOS 5 file system. The number changing from 2 to 3 should signify a major upgrade. 9to5Mac's Mark Gurman believed the device would get a dual-core A5 processor (that would open door to true 1080p) and a bluetooth support.
This Monday Gurman found that a new codename – J33 – has been assigned to Apple TV in iOS 5.1. According to Gurman, iOS release history tells us that Apple assigns a proper codename to products that move closer to release.
Both Amazon and Best Buy are now selling the Apple TV 2 for $89, $10 lower than the original price. Amazon also added "2010" label next to the product name, suggesting there will be 2011 or 2012 model coming soon. When? According to AppleInsider, the price drop doesn't suggest an imminent release of an updated model "as it is likely too late in the holiday season for Apple to launch a new product. The last time the company released new hardware in November was the Core 2 Duo MacBook in 2006." However, TechCrunch's Matt Burns believes that the new Apple TV may be released in the coming days: "The holiday spending spree is in full effect and Apple isn't one to ignore shopping trends. If it's not out soon, the next version probably wouldn't be released until 2012," he says.


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This Day in History, October 9
Published in History & Quotes
On October 9th, 1871, the Great Chicago Fire was brought under control.
Published in History & Quotes
On October 9th, 1871, the Great Chicago Fire was brought under control.
A thought for the day: A good hockey player plays where the puck is. A great hockey player plays where the puck is going to be. -- Wayne Gretzky
On this date in history:
In 1777, British troops occupied Philadelphia.
In 1950, U.N. troops took the South Korean capital of Seoul from North Korean forces.
In 1960, the first televised ...Read More
Those born on this date include:
- Frontier nurseryman Johnny Appleseed Chapman in 1774
- German researcher Ivan Pavlov in 1849
- poet T.S. Eliot in 1888
- German philosopher Martin Heidegger in...Read More
Today is Monday, Sept. 26, the 270th day of 2016 with 96 to follow.
The moon is waning. Morning stars are Jupiter, Mars, Uranus and Venus. Evening stars are Mercury, Neptune and Saturn.
On September 26th, 1934, the RMS Queen Mary was launched.
A thought for the day: We in America do not have government by the majority. We have government by the majority who participate. -- Thomas Jefferson


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STARmeterSEE RANK
Down 347,128 this week
Louis Adlon (1907–1947)
Louis Adlon was born on October 7, 1907 in Berlin, Germany. He was an actor, known for Counter-Attack (1945), The Big Show-Off (1945) and Mystery Sea Raider (1940). He was married to Rose Davies. He died on March 31, 1947 in Los Angeles, California, USA. See full bio »
Born:in Berlin, Germany
Died:(age 39) in Los Angeles, California, USA


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Mattb1's Blog
Monday - August 3
Didn't sleep well last night. It was really windy and our furniture on our roof deck kept blowing around. I was too lazy to get up and go tie it down. I would just fall asleep and then hear a chair go flying across the roof.
I may try and get a short ride in tonight as my legs are tired from yesterday.
Rest Day Today
I may try and get a short ride in tonight as my legs are tired from yesterday.
Rest Day Today
Sunday - August 2
- RACE DAY: Rock 'N' Roll Chicago Half Marathon
mattb1's Training Log
Upcoming races
- September's totals
- August's totals
- 2016 totals
- 2015 totals
Run: 2h 55m - 17.57 Mi
Crossfit: 1h 00m
Bike: 2h 55m - 51 Mi
Run: 32m - 3.01 Mi
Crossfit: 5h 00m
Bike: 14h 35m - 257.06 Mi
Run: 26h 22m 49s - 169.79 Mi
Strength: 2h 55m
Crossfit: 47h 00m
Elliptical Training: 30m
Swim: 20h 08m 28s - 60812 Yd
Bike: 80h 10m - 1432.91 Mi
Run: 75h 11m 08s - 486.71 Mi
Strength: 5h 30m
Crossfit: 37h 00m


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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It is the season for vacations, family reunions and those wonderful school programs! Everyone needs to have a wonderful ultra-compact digital camera to record all of the moments that'll become beautiful memories. Nikon has a great CoolPix S52 that'll fit your pocket and your pocketbook!
This wonderful red model is tiny, yet powerful! Loaded with 9.0 effective Megapixels, you get amazingly crisp details in all of your images. Light sensitivity has a hug range, from ISO 100 to 3200. From candle light to daylight on snow, you will get gorgeous professional quality photographs, consistently! Be ready to take pictures of the dramatic entry of the birthday cake, candles all aglow, or the magnificent color contrast of a cardinal against the first snow fall.
Become the Photographer you know you can be with the help of Nikon. The CoolPix S52 is tiny enough to fit into your pocket, and powerful enough to go everywhere with you. Never again miss the perfect shot, with this lovely Nikon in red!
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GRAND RAPIDS, Mich. — Meijer is offering customers more information about local growers through Facebook, Pinterest and Twitter. CONNECT WITH SN ON TWITTER Follow @SN_News for updates throughout the day. On Facebook and Twitter, Meijer shoppers can not only learn about the different types of local produce stores are selling, but also which farm the product was sourced from. "The locally grown cabbage sold in stores in Illinois this week is from DeGroot Farms ...
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Pill and Pen: Contraception and Unwanted Pregnancy in Global Literature and Popular Culture
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Call for Papers
Pill and Pen. Contraception and Unwanted Pregnancy in Global Literature and Popular Culture
Fr, March 7 to Sunday, March 9, 2014
Division of World Languages, Literatures, and Cultures University of Iowa, Iowa City
Symposium organizers: Waltraud Maierhofer (German; U Iowa), Walter Gruenzweig (American Studies; TU Dortmund), Elizabeth Heineman (History / Gender, Women, and Sexuality Studies, U Iowa)
The symposium seeks to explore the discourses of birth control in recent fiction and film as well as in artifacts of popular culture.
Contraception is not a purely personal matter. Authors around the world continue to challenge the dominant cultural discourses in their advocacy of birth control, or in the case of 2012 Nobel Literature Prize Winner, Mo Yan, criticize the strict birth control policies of their country. A British journalist writes a column about his experiences participating in a clinical trial for the male birth control pill. Although the topic seems widely absent in otherwise highly sexually charged American TV shows, the libido-boosting best seller Fifty Shades of Grey explicitly discusses contraception. A Mexican film (The Crime of Padre Amaro/ El Crimen del Padre Amaro, 2002) becomes an international hit – and provokes a "Christian" film with a different stance on abortion (Punto y Aparte/ Critical Point, 2002). Abortion also shows up as motif in crime fiction such as Henning Mankell's Before the Frost. Michael Glawogger's documentary Whore's Glory (2011) points out abuses of contraceptive pills and neglect of STD prevention. Popular fiction and film tell the background of the Comstock Law (Sex Wars: A Novel of the Turbulent Post-Civil War Period by Marge Piercy, 2005) and the Birth Control movement (Choices of the Heart: The Margaret Sanger Story, TV 1995).
The symposium will explore the way these questions are shaped imaginatively in different genres and attempt to view these discourses as expressions of social and cultural conflicts negotiated around the world. The comparative and international focus will be a key aspect of the conference.
Keynote speaker: Carl Djerassi (born 1923, Vienna), is an Austrian American chemist, novelist, and playwright. As a scientist, he is best known for his contribution to the development of oral contraceptive pills. In the past twenty years, he has produced a large number of novels, plays and also poetry which he subsumes under the genre of "science-in-fiction" and "science-in-literature" and which are translated, published and presented all over the world. An ardent collector of Paul Klee, he is also known as a supporter of the arts, especially through the Djerassi Resident Artist Program in California. Djerassi, professor emeritus at Stanford University, lives in San Francisco, London and Vienna. Three of his total of 30 honorary doctorates were awarded for his achievements in literature and the arts. His reflections on the pill and reproductive technologies are contained in, among others, This Man's Pill: Reflections on the 50th Birthday of the Pill (2004), An Immaculate Misconception: Sex in an Age of Mechanical Reproduction (drama, 2000), The Pill, Pygmy Chimps, and Degas' Horse (1992), The Politics of Contraception (1981).
Please send title, abstract (up to 300 words), and one-page resume to either firstname.lastname@example.com, email@example.com, or firstname.lastname@example.com by Oct. 1, 2013.
For select sections, complete papers will be expected before the symposium and distributed to participants.
Conversations are afoot to publish select papers as a volume.
Waltraud Maerhofer
Division of World Languages, Literatures, and Cultures
111 Phillips Hall
Iowa City, IA 52242-1323
319-335-2990 (fax)
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RPG-FPS hybrid Borderlands 2 finally has release dates: September 18 for North America and September 21 everywhere else. And for PC fans looking forward to the promised features and optimization, you won't even have to suffer a delay -- it's a simultaneous release for once.
Going along with the news, we've the "Doomsday trailer", which goes over just about every aspect of the game you could possibly want, and throws in that crazy chainsaw music the kids like for good measure. Enjoy, then get off my lawn.


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U.S. Close to Suspending Syria Diplomacy With Russia Over Aleppo Bombings
The Obama administration is considering alternatives, including military options, to bring about the end of the Syrian war.
The Obama administration is considering alternatives, including military options, to bring about the end of the Syrian war.
Comment from U.S. State Department regarding potential terrorists' targeting of Russian targets was an 'emotional outburst,' says Moscow.
Men were killed under accusations of collaboration with the Egyptian army.
The editorial in the Saudi Gazette cites the late Egyptian President Anwar Sadat's address to the Knesset in the course of a visit that paved the way for a peace treaty between Israel and Egypt.
Homa Hoodfar returned to Canada via Oman, a brief report on the state-run IRNA news agency said.
U.S. responds saying Iran is disappointed by international caution about doing business with Tehran.
Commentators suggest the firebrand populist will run in next year's elections, but Ayatollah Ali Khamenei's instruction effectively destroys his chances.
Russia and the U.S. failed miserably at managing the cease-fire they orchestrated, and are both responsible for the absurd situation now delaying the assault on ISIS' stronghold.
Jordanian Prime Minister Hani Mulki, who has held senior diplomatic and ministerial posts, is given another term to continue to try to rejuvenate a sluggish economy.
Some 100,000 people in the military, civil service, police and judiciary have been sacked or suspended following the failed July 15 coup attempt.