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Simple Image Editing
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I Need to alter some photos, it's just very simple [url removed, login to view] images of girl and boy , i need to change the outfit of the girl to a bride.
the whole budget is 20$
if any is interested please send me samples of the same editing
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Friday, July 19, 2013
Club member Randy Myers, left, receives the "Four-Way Test" award from visiting District Governor Lou Mello. The Rotary Four Way Test is the governing principle which members live by. The Summerville Evening Rotary Club is the newest club in District 7770 and meets at Montreux Bar & Grill Restaurant, 127 West Richard Ave, Summerville, SC Monday's at 5:30 PM. All are welcomed.
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tragic hero
at the center of a tragedy is its hero, the main character, or protagonist. The tragic hero is a person of high rank who accepts his or her downfall with dignity
tragic flaw
an error in judgement or a weakness in character such as pride or arrogance (helps bring about the hero's downfall)
a tragedy ends with a catastrophe, a disastrous conclusion that usually involves multiple deaths. if the tragic hero does not die, then he/ or she suffers complete ruin
throughout a tragedy a chorus, a mass group of actors, observe and comment on the action through song.


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Harry Dresden, Chicago's only professional wizard, takes on a case as a favor to his friend Thomas-a vampire of dubious integrity-only to become the prime suspect in a series of ghastly murders.
From the Paperback edition.
From the Paperback edition.
"Edge-of-your-seat adventure."—SF Site
"This imaginative series continues to surprise and delight with its inventiveness and sympathetic hero."—Booklist
"Good fun for fans of dary fantasy mystery."—Locus
""As usual in Butcher's books, the action begins on page one and moves rapidly from there."—Best Reviews


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Baby's first radiation poisoning.
Fallout 3 : Oblivion-developer 's open world post-nuclear apocalyptic RPG thingy, combining dread and depression with a smiling 50s cartoon character!
Story : The character creation system and tutorial are not-so-subtly tied into your character's birth and upbringing, within a giant Vault that's been shut of from the rest of the world. When you're father (voiced by Liam Neeson and why not?) suddenly escapes, all hell breaks loose and you escape the Vault and into the desecrated remains of a post-nuclear-war Washington DC, where you can think about searching for your father, or just walking around town picking pockets and killing people. The main story doesn't get interesting until near the end, but you may as well follow it anyways since it'll open up more locations on the map.
Comparisons to The Elder Scrolls 4: Oblivion are indeed inevitable, so I'll get them all out of the way now. Yes you're more or less dealing with Oblivion in the future. No, isn't quite as big as Oblivion's world was, but it's a lot more interesting. Instead of 15 towns that are practically clones of each other and a lot of empty jungles and identical caves, you've got about 4 interesting towns, a wasteland filled with interesting set-pieces, unique sights and people that want you dead, and radiation poisoning. Yes, you're playing with guns instead of swords now. But the core ideas are the same; you can rob and kill anyone you please, with the predictable moral (you lose "karma" or ) and legal (people will want you dead for awhile!) consequences. You can pick up as much junk as your kleptomaniacal heart desire, which becomes somewhat important since you're going to need to scavenge and sell whatever may be valuable in order to make some money.
And that's when Fallout 3 started to develop an identity to me. One of the things I like is the sense that I was barely getting by in this desolate wasteland. Ammunition feels scarce, money can be hard to get by, and unless you're some kind of expert thief then you're going to be stingy on health packs. Any penny your frugal ass can make will be needed, and whether you choose to spend your hard-earned bottle caps on repairing weapons or health becomes some kind of important decision. When you level up, you get to choose which character attributes are upgraded, and you may have to think twice about putting everything into combat, as opposed to being able to independently fix weapons, pick locks or barter.
The downside to this scarcity of assorted commodities is that it becomes trickier to specialize in any combat style. You can't quite get by being an explosives or energy weapons specialist, as whatever weapons you elect to use in any given situation will be based on whatever weapons you actually have ammo for. I had the same problem with Bioshock where the whole idea of letting me level up certain areas was rendered null and void by how I was being forced to use whatever attacks I could actually afford to use.
On top of that, I always felt like I was missing a piece of the puzzle; some kind of crucial bit of knowledge that I would've had to have played the previous Fallout games to pick up on. Like a certain kind of strategy I would need to use to kill a Super Mutant without emptying out entire clips of bullets on one, let alone the next twenty. The in-game tutorial is great at explaining concepts that one would've known about from playing Oblivion, but certain other concepts, like whether or not there are parts of the body I should shoot at in VATS other than the head, or how to deal with enemies that can shoot me from a football field's length away when I can't shoot them unless football's length off, or even something as silly as the need to use abandoned subway systems to get to certain areas, seem to have alluded me in my inexperience with this franchise. The key here is that I can't be alone; the vast majority of people buying Fallout 3 have more than likely never played a Fallout game before.
And thus, combat is a mixed bag. You have to adapt to the idea that everything is stat based and thus you won't be able to instantly headshot and kill everything like some kind of deathmatch uber 1337 creature. My biggest annoyance is that the farther you are from a target, the less likely you are to hit; a weakness your enemies don't seem to have. And being that you won't have a somewhat expendable supply of ammunition until late in the game, your strategy in combat will tend to be "rush up close to an enemy and pop them in the skull." To assist in this point-blank gunplay, the VATS system lets you expend a certain number of action points to automatically target key parts of the enemy, if you're not feeling confident in your reflexes and want to be stingy with ammo. If there's one advantage to this system, though, it's that successful kills will often result in some fantastically excessive death sequences with exploding heads and slow motion dismemberment.
I guess what I'm trying to say is that if Fallout 3 has a fault, it's that it has an unorthodox learning curve and difficulty curve. One of the earlier missions will require you to plow through a legion of Super Mutants despite your limited munitions. Unlike Oblivion, where if you never leveled up your hero, you could realistically be fighting rabbits and mice on the end-game levels, enemies don't seem to get progressively more difficult as you level up; an angry Super Mutant will always be an angry Super Mutant, and can only get easier to kill as your stats improve and you wise-up to the game's mechanics.
But once you get into that groove, that's when you can start to appreciate the nuances. The otherwise long walks to any given destination on the map feel like fun little adventures into the unknown rather than some needless way of artificially lengthening the game. Characters are mostly interesting and have their own personality and pockets to explore. The juxtaposition of the wholesomeness of the 50s' perceived idea of and the horrific nuclear Armageddon makes for a distinct contrast that one can't help but get immersed in. There's a slight tinge of USA-bashing and that'll always put a smile on my Canadian face. If you look hard enough, there's a hearty assortment of fleshed out side-quests that you can wind up losing yourself in. The number of unlikely bonus stats or "perks" that you can give your character upon leveling up opens up a bit of experimentation and incentive to replay the game. And I guess once you've wrapped your mind around the stat-based combat, you'll welcome the challenge of battling armed soldiers with your shotgun.
I can't compare Fallout 3 to previous Fallout games but I'd wager that people who enjoyed those games will find radioactive bliss here. For fans of 's games, what you're getting here is a smaller, but more interesting and arguably more fun open-world RPG for you to pillage and fiddle with, or at least in the later end of the game when you can afford to waste bullets on something that wasn't trying to kill you first. For people who've never tried one of these games before, I'd say that Oblivion makes a better gateway drug into this genre; a warm-up, if you will, for the real exercise of Fallout 3. You kind of have to adapt to the game to really appreciate it, but once you do, it'll trigger a nice, warm, light-green glow in your heart.
Pros : Great 40s music to jive to while you maim ghouls and giant mutants.
Cons : Some glitches. I was of the impression that in earlier Fallout games that, with the right stats, you can play the entire game without ever getting into a fight. You SO can't do that here.
4 stars
Now I see why so many people geek out over that Fallout cartoon mascot.


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Started Mar 20, 2013 | User reviews thread
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JAWilson • Regular Member • Posts: 254
Re: E3O
In reply to BYRON MCD 77-81 • Mar 20, 2013
What are the tricks to kick the E30 in the ass for low light photography? I love the camera, but the low light issue pops up more that I would have expected.
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Photo of the Week: Haitian Mangoes Ripe for Market
August 02, 2013
The Haiti Hope Project is helping revitalize Haiti's mango industry and raise the standard of living for thousands of farming families.
A young Haitian farmer harvests Francique mangoes, a variety unique to Haiti and prized for its juicy, sweet flavor. Until recently, fewer than 5 percent of the mangoes produced in Haiti reached the export market, and farmers struggled to earn a viable income from their fruit trees. The Haiti Hope Project is helping create sustainable economic opportunities for Haitian mango farmers and their families.
The Haiti Hope Project is a public-private partnership comprised of The Coca-Cola Company; the Multilateral Investment Fund (MIF), a member of the Inter-American Development Bank Group (IDB); the U.S. Agency for International Development (USAID); and TechnoServe. Haiti Hope aims to double the incomes of 25,000 smallholder farmers five years after they join the Project. TechnoServe is training local mango producers and connecting them to international markets. To date, more than 23,000 farmers – nearly 50 percent of whom are women – have enrolled in the program. This year, more than 450 tons of fresh mangoes were sold through Whole Foods stores throughout the United States, a 150 percent increase from last year.
Learn more about the Haiti Hope Project.
Related Blog Posts
Integrating Farmers into Corporate Supply Chains
A sustainable agriculture initiative in Mexico illustrates how partnerships can help smallholders connect to high-value markets.
TechnoServe and Partners Win the P3 Impact Award
Project Nurture receives prestigious award recognizing collaborative excellence in a cross-sector partnership.
Stronger Food Businesses, Better Food Security
To help #endhunger, TechnoServe is working with Feed the Future to strengthen agribusinesses and food processors in Africa.


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Top Definition
The act of applauding a shot made by a golfer in the British Open. The applause is almost always muffled because the patrons are quite often freezing their asses off in bloody blustery conditions, and they refuse to remove their gloves/mitten/hand warmers out of fear of frostbite or gangrene.
Me lad Rory McElroy heard Golfclop all around the Road Hole when he covered the flag with his second.
ayon kay JohnnieWBlue ika-14 ng Hulyo, 2011
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Can you define these popular missing words?


text: Thank you to all who participated in the photo contest this year! We received over 240 submissions in five categories. With so many beautiful photos to choose from, it was difficult to pick just one! We'd like to congratulate the following winners, whose breathtaking images are listed below, and also featured in the Contest Finalists web gallery.


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After the World Trade Center collapsed in New York, Thomas and Kathleen Snider saw their Los Angeles beachfront home in a different light. The Los Angeles Harbor, their neighbor, seemed a vulnerable target for more terrorism, and suddenly, their perception of their life together changed.
Married for 20 years, the Sniders have a 19-year-old daughter who lives with them. They also have four adult children from prior marriages and a combined eight grandchildren but, until Sept. 11, no will or estate plan to express how they want their assets distributed after they die. The attacks prompted the Sniders to contact a lawyer and arrange their wills.
And they have plenty of company. Thousands of Americans are addressing their personal affairs, turning to lawyers who handle wills and estate planning, as well as Internet sites that offer online services. The attacks on the World Trade Center and Pentagon, followed by the anthrax scare, are forcing people to deal with issues they had ignored or put off till later.
"After this thing in New York happened, we started thinking, 'What if they attack one of these ships in the harbor, or more than one, or one of the fuel transfer stations,' " said Thomas Snider, 52. "If it happened in New York, it could happen easily here. Maybe because of these events, we could meet with an untimely demise, and we had nothing in place. We have a rather nice home on the beach. We would like to see our one child stay there as long as she needed rather than have the state come in and decide."
Snider turned to Jeffrey Condon, a Santa Monica, Calif., estates lawyer and co-author of "Beyond the Grave: The Right Way and the Wrong Way of Leaving Money to Your Children," for assistance. Condon, who shares his estate-planning practice with his father, Gerald M. Condon, co-author of the book, said their clientele has doubled since Sept. 11.
"It's brought people closer to their mortality and their perception of their mortality," the younger Condon said. "People are doing more inheritance planning, insurance planning and those things they put off or never thought of because it's a new day. People are more aware that they can go at any time."
Senior citizens are amending their wills; young parents are drawing up wills for the first time, wanting to leave their children's legal lives in order, should they both die. Single people are wondering if they should do anything at all.
"In a sense, that's coping with something you can control," said Fred Zuker, a vice president at University of Dallas and professor of psychology who has conducted national workshops on coping with the national crisis. "So much of this is feeling the loss of control, even though that is just an illusion to begin with. To have that illusion yanked from our hands makes us look for things we can recover to get a sense of control. Taking care of your will is one little piece that you don't have to worry about."
The dramatic rise in estate planning marks a sharp contrast in the mentality of the average American who, just months ago, was not thinking much about bequeathing his or her money and other assets, experts say. A survey of 500 men and 500 women across the nation conducted in May by FindLaw, a legal Web site based in Mountain View, Calif., showed that estate planning was not high on the list of priorities of most Americans. About 59 percent of those polled did not have wills, said FindLaw spokesman Leonard Lee.
"It's very unfortunate to see an increase in our sales because of these horrific events, but at the same time, we do feel that everyone should have a will," said Brian Lee, president of L.A.-based LegalZoom.com Inc., which has seen a 50 percent increase in orders since the attacks. "People are filling out wills to protect themselves and their families because they're traveling. There are people who mention anthrax, and we're also getting a lot of traffic from individuals who work in tall buildings who are just scared."
Lee's 1-year-old company has been so overwhelmed with new business that he hired two people to help with the overload. People fill out an online questionnaire, and LegalZoom processes it and sends the customer instructions on making it a legal and binding document. The company is preparing free wills and living trusts for the families of those who lost their lives in the attacks and so far has donated $12,000 of its profit to the New York Fire Department Fund.
"This is such a phenomenon; it's so sad," said Alfredo Adessi, president of the Fort Lauderdale, Fla.-based Wills.com. "To have business doing so well because of such a huge tragedy is a very confusing situation. This crisis just seems to be going on and on. We had a 150 percent spike in the first week, and now it's at 125 percent. It's mostly coming from the metropolitan areas all over the country. This is not subsiding. What is more sinister than something being as close as your mailbox that could touch you or hurt you and your family? What is more scary than that?"
At Doyourownwill.com, a Chicago-based site, business also is booming. Traffic on the site as well as purchases have doubled - but 65 percent of those orders are from people who live east of the Mississippi, said president Brent Pope. The majority of sales are in Massachusetts, Connecticut and New York.
"A lot of people are contemplating things they've never thought about before," Pope said. "Not everyone needs a will. But everyone is definitely thinking about these things now."
As Zuker has traveled across the country this past month, he has witnessed the pulling together of families. The rise in estate planning is an extension of the rush for Americans to take care of their loved ones, he said.
"People are reconnecting with their families, planning reunions and turning to family and friends for sustenance," Zuker said.
"These events have caused people to reprioritize and reassess what we need to do. Thinking about one's will and getting one's financial matters squared away goes with that type of thinking."
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text: Didnt do last year because of the proximity to Woodshop, hence the "fourth". Same as every other year. As usual I have WAY too much beer so I'll be opening plenty of bottles but you're welcomed to bring what ever you want. Sunday September 2nd. Thats opening weekend of the LA county fair, and it's 5 blocks away from the north gate. Plenty of parking available here. No whales needed, no ticks needed, just show up with a beer (or as much as you want) and some food. I'll have 2 gas grills and a charcoal grill if anyone wants to cook on those as well as access to the stove/oven and microwave inside if anyone needs those. Could definitely use some lawn chairs and easy ups. Will have the keg fridge running if anyone wants to bring homebrew kegs (pin lock only right now). Thinking of 1pm as a starting time again. **bring your own glassware. The adress is in the event page (I'm close to the LA County Fair in La Verne if you want a rough idea). If we only have 20-25 people I'm fine with that but I would like to cap this around 50 if I get that much interest so RSVP on the event page . Will post the event page soon (I forgot that it takes a while for the events to be approved here).


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Arslan on Huck Loss: I Was Robbed, This Ruins Boxing
On Saturday night, Marco Huck retained the WBO cruiserweight title when he beat Firat Arslan in Halle, Germany. Making his tenth defence, the champion won on points – 115-113 on two cards and 117-111. The decision was greeted by a chorus of boos, as many spectators felt the 42-year-old Arslan had done more than enough to beat his German compatriot, who is younger by 15 years.
"This fight was the biggest scam I have ever seen. It's a disgrace," Arslan's coach, Dieter Wittmann, said.
Arslan, a southpaw, forced the initiative throughout, after rocking Huck with a left uppercut to leave him with a bloody nose in the second round.
Huck finished the third with a flurry of punches to rouse the crowd, and he responded again in rounds seven and eighth, but the elusive Arslan appeared unbothered, even raising his arms in triumph after the ninth.
Arslan's intensity then dropped slightly and Huck finished strongly. Former WBA cruiserweight title holder Arslan, who dropped to 32-6-2, 21KOs, was furious.
"I've never experienced anything like this decision. I've seldom landed so many clean punches and he only scuffed me," Arslan said. "How can such a thing happen? This kind of thing is ruining boxing. I think the whole crowd believes I'm the winner. I've been robbed of my win. I would have been the new world champion today. I would have written history."
Huck, who may face mandatory challenger Ola Afolabi for the third time in early 2013, brushed off any discussion of a robbery.
"It was hard work. He fought like a lion; worked very hard," said Huck, who improved his record to 35-2-1, with 25 knockouts. "I'm not a judge. I think I landed more punches."
Even the German commentators were saying that arslan had it over him and that huck needed to do something to win the fight,that was till the 6th round or so..then suddenly for some reason the commentators started to give huck…Comment by ShoulderRoll on 11-04-2012
Another Sauerland decision. I've seen this guy lose to Lebedev and now to Arslan, both times he somehow got awarded the win.Comment by johnnycontrolet on 11-04-2012
The typical cheating at Sauerland Fights in Germany. Huck had lost to Lebedev, to Afolabi....but we always hear the same nonsense explanations from Sauerland........Comment by sweet-s on 11-04-2012
If one considers the criteria of professional boxing, it becomes obvious, why Huck has lost the fight. Scoring all indiviadual rounds, the outcome must be in Arslan's favour. 1. effective aggression: For about 90% of the fight Arslan scores body…Comment by paulf on 11-04-2012
Huck doesn't want to fight Afolabi again. Let him move up and make Afolabi-Arslan for the vacant title. Another war. :boxing:Post a Comment - View More User Comments (10)


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OPEB (Other Post-Employment Benefits)
Generally speaking, OPEB refers to retiree healthcare but can also include other benefits for retirees like life insurance or legal coverage. Unlike pensions, which is also a "post-employment benefit," retiree healthcare is generally not protected or guaranteed. There is also no requirement to pre-fund the benefits whereas pension benefits are paid out of an investment fund maintained by the government. These characteristics have two main consequences: 1) OPEB costs are (except in a very few jurisdictions) are "pay as you go" and governments budget only enough money each year to pay the immediate bill for the retirees. 2) Mounting OPEB liabilities generally don't get the same attention pension liabilities do even after accounting rules were changed in 2007 to require that governments estimate their OPEB liabilities on their balance sheets.
As Joshua Franzel, vice president of research for the Center for State and Local Government Excellence, puts it: "For the most part it's easier to change the benefits or eliminate benefits [as] governments can tweak around the edges or cut out a lot of the subsidies they provide. [So] when these costs continue up, states are shifting more costs over to the retiree."
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Notre Dame's Kyle Camp earns Top 10 finish at prep All-Star event
MARKSVILLE – Notre Dame's Kyle Camp had high expectations going into Wednesday's Louisiana Champions Invitational at Tamahka Trails Golf Club.
But following a bogey, bogey start on the first two holes, the junior golfer was never able to recover.
Camp, whose trip to the All-Star invitational was his third straight, shot a round of 80 and finished tied for 10th place with Shaw's Matt Miller and Loyola Prep's Kirk Thomas.
"I knew it was going to be rough after I bogeyed the first two holes, but I knew if I could get it back around to somewhere near even-par, it wouldn't be that bad," said Camp. "I knew I had to make some birdies to get back into contention."
Camp, the fourth place finisher in the Division III tournament two weeks ago, rebounded with pars on the third and fourth holes before dropping in a birdie on the par-5 fifth hole.
"I had a really good drive and a good second shot and I was right next to the green," said Camp of the fifth hole. "I hit a little chip to about four feet and made my birdie putt."
Camp, who shot an 85 in last year's event, had an opportunity to get to even-par on the par-3 sixth, but his birdie attempt lipped out.
"I had a good drive, but my putt just lipped out," said Camp. "That could have been a good little streak if I could have put it together."
A bogey followed on the seventh hole and Camp made the turn with a score of 38, six strokes behind the leader and eventual champion Eric Richard of Loyola Prep.
The backside wasn't as kind to Camp, who made eight bogies and one birdie over the final nine holes.
"The course wasn't really playing that tough, but my putting was just awful," said Camp. "I only had one 3-putt on the front and I had maybe five on the back. My putting just dropped off."
The course was set up at collegiate levels for the tournament, with the boys playing the par-71 Tamahka layout at approximately 6,800 yards which is significantly longer that the average prep layout.
"The course plays really long when they tip it out and it was playing long today," said Camp. "I was hitting the ball good so it (the length) wasn't too bad. But I definitely could have shot better than what I did. I think I could have probably shot a 72 easily if I just would have made some putts."
Richard, the Division III state champion, won the event by posting a 6-under par 65. His score set the invitational low-round record.
Salmen's Jennifer Nguyen also set a tournament record by shooting a 73 to claim the title in the girls' division.


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Historical Traveler Reviews Pestana Arena Barcelona
Vincci Arena -NOT near Convention Ctr despite Hotels.com map
Beware Hotels.com finder to landmark booking feature; Vincci Arena is NOT "0.5 Miles From Barcelona Convention Center ". Despite also showing on Hotels.com location finder tab, this hotel is miles from conference center so couldn't practically attend conference in the evenings.
Vincci Arena is IKEA modern (lime & purple colors, drop pendant lights, drapey sheers on windows), firm beds, modern bathroom fixtures but noticeable corners have been cut that don't put Vincci in the same class as AC Barcelona Hotel.
The staff have very limited English with only 1 or 2 people at the front desk, would not place collect calls for me to report stolen purse to cancel cards, wouldn't call police for me to make police report, air conditioning was NOT functioning and no one fixed it - not able to sleep due to excessive HEAT in room. The heat outside was around 80 combined with the hallways which are stifling due to 5 foot tall deco lights of room numbers heating the hallway combined with no ventilation caused the rooms to be very hot. My guess is the hotel simple has turned the air conditioning completely off due to it being October.
No concierge to assist in directions, restaurant, attractions, etc. Also parking is so narrow it's like driving down a spiral staircase; I know how to drive a small car w/stick shift and I had barely 2 inches from the walls as I drove down the extremely narrow spiral, steep driveway. Others had left parts of their cars on the walls I could clearly see, so unless one is driving a LeCar, the parking is difficult.
Fitness center - really poor: 2 bikes & 1 treadmill in a 12' by 12 foot room. Again it is nothing like the multi-machine, free weights, airy, wall of windows at the AC Barcelona fitness center with roof top pool.
Good 4 star hotel
I spent just 2 nights at the Vincci Arena and i can say that is a good 4 stars hotel.
The hotel is located just 1 block from subway line 1 ( Tarragona ) and line 3 ( Espana ).
My room, as showed on website, was clean, modern with an excellent bed.
Staff very helpfull.
I will be back at the Vincci
Wonderful Hotel
We just spent 3 nights and wish we would of booked for a full week here.
The location was perfect, just a block from the rapid transit station. Also close to lots of cheap local restaurants that had great food.
The hotel staff was very helpful and friendly. The airlines lost our luggage and the staff was so helpful in making the calls to help locate it for us. They all spoke excellent English.
I loved the modern decor in our room, everything was very comfortable. The lighting was a bit different and took a few minutes to get it all figured out. The rooms were very quiet, no outside noise. We would certainly stay here again.
Well, I have to say if you are traveling for buisiness to Barcelona...do not stay here. There is no internet in rooms, only available in the lobby, so you can imagine if you are doing buisiness then that is a big problem...
Room service stops at 11:00 PM, thus there is no 24 hour service which is rather odd for a hotel that claims to be 4 stars...
Service was good, there was a gentleman by the name of Javier who was very helpful and went out of his way to make the stay as pleasent and comfortable as possible. Unfortunately although the service was good the lack of in room internet and 24 hour room service makes this short of a 4 star hotel...
Very Clean, Great Location
Just returned from a one night stay at the end of a cruise. We had two rooms (both on the small side, and one slightly smaller than the other) and the overall experience was great. Fantastic location, quite close to the metro and the train station (5 minute walk to either). We thought the beds were very hard, but given that the air conditioning worked so well (unusual in Europe) we could forgive them this. Rooms were very quiet. I was quite surprise to learn that the hotel had no iron available for pressing clothes and the shower only reached a lukewarm temperature. But, the staff was very friendly and the hallways being uncooled was really no big deal.
Encore un petit effort...
Nous pass� trois nuits dans cet h�tel la semaine derni�re. Nous avions r�serv� deux chambres. Celles-ci b�n�ficient d'une tr�s belle d�coration, peut-�tre un peu lugubre parfois, mais tr�s design. C'est un lieu calme et agr�able qui offre les "facilities" des grands �tablissements. Je dirais m�me que les salles de bains sont remarquablement bien �quip�es et agr�ables. Il y manque pourtant un minimum de climatisation dans le couloir et, plus emb�tant, un accueil souriant. Le personnel est carr�ment d�sagr�able, ce qui correspond bien � l'emplacement de la r�ception, dans un coin du hall d'entr�e et dissimul�e derri�re des plantes. Nous n'avons pas eu un seul sourire, nous avons eu du mal � nous faire comprendre (nous ne parlions pas espagnol, mais anglais et fran�ais...) et l'une des deux chambres que nous avions r�serv�es par Internet �tait d�j� occup�e (une petite erreur vite r�gl�e et dont je ne parlerais pas ici si le sourire et les explications avaient �t� � la hauteur du nombre d'�toiles pos�es sur la fa�ade de l'�tablissement). Le petit d�jeuner n'est pas compris dans le prix de la chambre et il n'est pas donn�. En revanche, le buffet est riche et vari�, � deux d�tails pr�s : sa r�frig�ration qui laisse � d�sirer (le fromage qui transpire, c'est l'horreur...) et le caf� qui est limite imbuvable (pr�f�rer le th�...) Un bel h�tel, bien situ� donc, mais qui devrait soigner les d�tails, car chacun conna�t l'histoire du d�tail qui tue...
Fantastic hotel
I stayed at this hotel with my partner and we both want to rush back. The slight niggle first. The hotel is situated on carrer central de cent which is a street split in two by parc juan miro. most taxi drivers have not discovered this new hotel yet ... so they more often than not try the other side of the street (not surprisingly as it is the longer portion). The hotel is extremely well situated near to the plaza espana - about 1 min walk away and within 1 min walk of two metro stations. The hotel is exceptionally modern in design and furnishings. The staff were extemely helpful and went out of their way to help us. The rooms are spacious with excellent lighting, air conditioning and very comfortable beds. The bathrooms are amazing - so cool and relaxing. The corridors leading to the rooms are very warm due to some strange green lights outside each guest room - but how long do you spend in the corridor? The breakfast is not expensive in my view for what you get - there is a good range of options and the waiting staff are incredibly friendly. i would have preferred there to have been an option of a restaurant in the hotel - but there are some amazing places to eat in barcelona. i can not recommend this hotel highly enough.
Nice hotel
We just return from Barcelona where we stay at Da Vincci Arena for 3 nights. General comment is that hotel is very new and that I would stay there again. Rooms are nicely decorated, ligths can be adjusted on 1000 ways, bathroom is very nice, location is very good (few minutes walking distance from Plaza Espana), air conditioner worked excellent.
Problem was with coridors which are not air conditioned and it was very hot. Also when I came to the room I found door of mini bar open, so all drinks been warm. There was nothing to open beer with. I found breakfast quite expensive (14 Euros). For 12 Euros you can have nice breakfast for 2 people 150m from hotel on your way to Plaza Espana.
Great hotel, still new but a few growing pains
I stayed at the Vincci Arena for 3 nights in May, 2006 with my girlfriend. I decided to try it out since it was a new hotel and looked great from the website.
The room is a good size and brand new! What can I say...everything was brand new..so you can't complain about something being dirty or having any funny odors. The beds were nice and firm, all the sheets and towels were replaced daily. There's a nice LG LCD screen to watch tv when you're in the room.
This hotel is brand new and it appears that they are still working on things. It does get a bit dusty in the hallways when they are still working on a room on your floor. Other than that, there was no noise from neighboring rooms, so I guess everything was soundproofed very well!
The reception desk in the hotel is a bit oddly placed. As soon as you walk through the entrance, it is on the right hand side, and a bit small and hidden by a plant.
It is about 2-3 mins walking distance to the nearest metro station. From there, it is only about 3 stops to get to Placa Espana for shopping and walking along La Ramblas.
Anyhow, I have no problems with this hotel. It is brand new and was a good value. I've attached some pix of the room I stayed in to give everyone an idea. I would stay there again, no problem.
Pick up a map
As I am apparently the first to write a review of this hotel, I shall be fairly concise and offer what I would consider to be a reasonably fair assessment.
The staff were most pleasant and helpful catering to all of our needs when required.
The hotel appeared to be both clean and efficiently run.
The rooms seemed to me to have a slight sophistication about them although a little on the small side and were quite tastefully designed with an eye for detail.
The hotel is fairly well situated with easy access to shops cafe bars etc.
You WILL require a taxi if intending to go to Las Ramblas as it is some distance.
Be aware however if catching a taxi on the way back, ensure you have the hotel address and if neccessary a MAP of the area which you can obtain free of charge from the lobby.
The vast majority of Spanish/catalan people are extreemely warm and freindly,however taxi drivers in Barcelona have this uncanny habit of conveniently forgetting where they may find your hotel, particularly in the early hours when their passengers may be a little worse for wear.
Anyhow I would certainly stay at this hotel if returning to Barcelona.
TripAdvisor Reviews Pestana Arena Barcelona
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... Hammie and my favorite section was the Medieval Gothic Art - 1200 to 1500. Lots of gold. All religious of course. Really good to see the development over the period. We had a brief look at modern Art. Not my thing. I liked some of the Art Noveua.
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... For lunch we visit Ciudad Condal - a very popular tapas bar and wait for 20 mins for a table. The wait is worth it. We order Iberian ham (beautiful thin strips of tasty ham like no other ham I've ever tasted) and Paella. The Paella incorporates seafood and is noodle based (not rice). We cancel the assorted Tapas we had ordered as we are already satisfied. Of course the meal was washed down with a gorgeous Rose wine. Di managed to save ...
Gaudi, Flamenco & a Dancing Fountain
... at the hotel, I stretch out on my bed and blog for a bit. We have 3hrs to ourselves. Athena went off walking with Jose. I booked another massage. Yes, I love massages. Throughout the massage, with eyes closed, I would hear a funny noise, then realised it was me! Sleeping and snoring. The girl simply smiled at me. The outside pool upstairs is a bit luxurious. Views over 'B'. A big bar. Happy. At 4.15 off for dinner. We walked down ...
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... himself a satchel bag for going to work which is made from the colourful vinyl festival and cultural banners from around the city. We decided to throw his Haviana's in since he hasn't worn them and on the postage declaration we wrote a bag and thongs. The postal worker didn't speak or read any English and as pointing to our feet didn't work, Jus tried using Google Translate to get across to her what thongs are. He typed in thongs and it translated ...
I found Barcelona to be one of the coolest cities I've visited in Europe in my travels so far. Despite some two millennia of history it felt like a city that was very forward thinking, always on the cutting edge of art, design and cuisine. Whether I was exploring the cities medieval palaces and plazas, gawking at the Modernista masterpieces, admiring the designer clothing stores along the busy boulevards, dining on delicious tapas, paella and ...


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Gang Leader Gets Life In U.S. Consulate Murders
A Mexican gang leader has been sentenced to life in prison for his role in the 2010 murders in the border city of Ciudad Juarez, Mexico, of a U.S. consulate employee, her husband and the husband of another employee.
Prosecutors say Arturo Gallegos Castrellon was sentenced Thursday. A judge also ordered him to pay over $1.7 million in restitution and forfeiture. He was found guilty in February of three counts of murder.
Prosecutors say evidence presented at trial showed he was in charge of a team of assassins with the Barrio Azteca, a gang allied with the Juarez drug cartel, and had ordered the three slayings.
Of the 35 defendants charged in the case, 26 have been convicted, one committed suicide in jail and two remain fugitives.
Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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5 Smooth & Summery Smoothies
Banana Cashew Smoothie from Real Simple. It sounds so creamy, refreshing and a really delicious snack. There are smoothies for just about anything: health, diet, snack, dessert — you name it and there's a smoothie for it. Here are 5 smooth and summery smoothies to try: • Strawberry Pineapple Smoothie, Annie's Eats • Green Machine Smoothie, Cookie and Kate • Spring Forward Vegan Smoothie, Lunch Box Bunch • Banana Cashew Smoothie, Real Simple • Watermelon Smoothie, Martha Stewart Related: (Images: Annie's Eats; Cookie and Kate; Lunch Box Bunch; Real Simple; Martha Stewart)


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The Cranberry Show previews new album "Paranormal Karaoke" on The Mad Kids tonight
Make sure you tune in to the Mad Kids Radio show tonight where I'll be interviewing The Cranberry Show about their new album Paranormal Karaoke, which drops tomorrow. And did I mention the album will be FREE and hosted on Djbooth.net and DonutsandMilk.com. Yep, I just did. Come back tomorrow and I'll post the interview and even more music for you.
Mad Kids Radio Show - 91.7FM WMSE, 9-12 or stream live at www.wmse.org »Read Full Blog Post


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The Genomic Medicine Institute (GMI) serves as the expert base for the principles and practice of genomic medicine, including genetics and genomics research, clinical care, and outreach and education directed at genomics-based personalized healthcare. Research conducted at GMI focuses on both translational and clinical human genetics and genomic science, meaning discoveries made in the laboratory will advance the field of precision medicine and, ultimately, improve the quality of patient care.
GMI, founded over a decade ago by Charis Eng, MD, PhD, Chairperson, is specifically designed with open laboratory space in order to enhance genomics research. Researchers work together with clinicians in the clinical arm of the Institute — the Center for Personalized Genetic Healthcare — as well as the Genomic Medicine Biorepository, which processes and stores thousands of patient samples and biological molecules linked to a relational database, and the Genomics Core facility, which utilizes cutting-edge genomics technology for multiple researchers within the Cleveland Clinic and externally.
The Institute offers a unique training program to young investigators who wish to apply genomics to their research or medical practice. GMI also coordinates genomic research and practice across many disease areas to enhance interdisciplinary research and healthcare.
The Genomic Medicine Institute's (GMI) 4th annual Genetics Education Symposium entitled, "Genetics & Genomics: Advances Across the Lifespan" was held on Thursday, September 15th at the InterContinental Hotel and Conference Center in Cleveland, Ohio. This day-long symposium was attended by over 150 healthcare professionals and students from a variety of organizations.
The presentations focused on advances in the diagnosis, management, and treatment of genetic conditions during all stages of life, from prenatal conditions to Alzheimer Disease. Presentations included: Genetics Primer & Clinical Updates by Angelika Erwin, MD, PhD, Expanded Carrier Screening – What you Need to Know by Amy Shealy, MS, LGC, Recent Advances in the Treatment and Management of Cystic Fibrosis by Silvia Cardenas, MD, Advances in the Management of Duchenne Muscular Dystrophy by Neil Freidman, MBChB, Autism Genetics – PTEN and beyond by Thomas W. Frazier, PhD, Thoracic Aorta Aneurysm and Dissection by Apostolos "Paul" Psychogios, MD, FACMG, Update on Clinical Breast Cancer Genetics by Holly Pederson, MD, Colon Cancer by Brandie Leach, MS, LGC and The Role of Biomarkers in Current Diagnosis of Alzheimer's Disease by Jagan Pillai, MD, PhD. Charis Eng, MD, PhD, Course Director, founding Chair of the GMI and Director of the Center for Personalized Genetic Healthcare, concluded the day with her presentation Your Genes, Your Wine, Your Health, followed by a wine reception.
This year's program also included new platforms such as patient panels and brief overviews of GMI research. The patient panels involved four patients and their families sharing experiences with genetic diagnosis and counseling. These first hand experiences were enlightening and highlighted the value of genetic counselors. We also showcased GMI trainees who gave "lightning talks," or quick summaries, of GMI research and poster presentations displayed throughout the day.
Keep updated on all GMI events, seminars, and next year's symposium by subscribing to our newsletter. To subscribe, email Janece Schaffer-Burbank, GMI Education Coordinator at firstname.lastname@example.com.
Charis Eng, MD, PhD, Hardis Chair of the Genomic Medicine Institute (GMI) and Director of The Center for Personalized Genetic Healthcare (CPGH), has been awarded a Clinical Research Mentorship grant from the Doris Duke Charitable Foundation (DDCF). These competitive grants aim to strengthen the pipeline of clinical researchers in medicine by fostering personal, one-to-one mentoring relationships between well-established scientists and medical students. Dr. Eng, who has received this award multiple times and thus demonstrated her dedication to educating and advising the next generation, will mentor Victoria Byrd from Case Western Reserve University School of Medicine.
DDCF's Medical Research Program supports clinical research that advances the translation of biomedical discoveries into new preventions, diagnoses and treatments for human diseases.
Micheala Aldred, PhD, Associate Staff in the Genomic Medicine Institute (GMI), received the 2015 Outstanding Educator Award, presented at the annual Lerner Research Institute Awards for Excellence, held on April 12, 2016.
Nominations for this award are solicited from staff and leaders in the Cleveland Clinic Lerner College of Medicine (CCLCM) and Molecular Medicine PhD programs. Jonathan Smith, PhD, Director of the program, presented Dr. Aldred with the award in recognition of her extraordinary efforts as Course Director and teacher in the Molecular Medicine PhD program.
Charis Eng, MD, PhD, ACS Clinical Research Professor and Hardis Chair of GMI and Director of the Center for Personalized Genetic Healthcare (CPGH), has been awarded an honorary MD degree from the University of Liège, Belgium. The title of Docteur Honoris Causa was conferred to Dr. Eng due to her demonstrated excellence, leadership, novel thinking and remarkable dedication to her field of study.
Dr. Eng was recognized as being an acknowledged world-renowned scientist, physician and educator who has made fundamental contributions to the way clinical genetics is practiced in medicine around the world.
Charis Eng, MD, PhD, Hardis/ACS Professor and Chair of the Cleveland Clinic Genomic Medicine Institute and Professor and Vice Chair of Case Western Reserve University (CWRU) Department of Genetics and Genome Sciences, was an invited panelist at the Healthcare Businesswomen's Association (HBA) event entitled "Gender Bias in Science and Medicine: Understanding the Present to Change the Future" (watch now). The panel discussion, comprised of local science and healthcare industry leaders, addressed identifying gender bias in today's workplace and strategies of how to change it in the future. HBA partnered with the Cleveland Clinic Women's Professional Staff Association, CWRU, MetroHealth System, Biomotiv, and the Natural History Museum for this event.
Dr. Eng was joined by fellow speakers who collaborate with women in the sciences and healthcare throughout the city of Cleveland and beyond, including: Diana Bilimoria, PhD, KeyBank Professor, Chair of CWRU Department of Organisational Behavior, Akram Boutros, MD, President and CEO, MetroHealth Hospital, Laura Butler, CEO, WorkLife Performance Consulting, Evalyn Gates, PhD, CEO, Cleveland Museum of Natural History, Lynn Singer, PhD, Deputy Provost, CWRU and Juliana M. Woda, PhD, Project Manager, BioMotiv.
The Healthcare Businesswomen's Association is a global nonprofit organization comprised of individuals and organizations from across the healthcare industry committed to achieving gender parity in leadership positions, facilitating career and business connections and providing effective practices that enable organizations to realize the full potential of their female talent.
The Genomic Medicine Institute (GMI) has been awarded a Southwest Airlines Medical Transportation Grant for the fourth consecutive year. The grant provides complimentary, round trip tickets to patients with PTEN Hamartoma Tumor syndrome (PHTS) to visit the PTEN Multidisciplinary Clinic within the Center for Personalized Genetic Healthcare (CPGH). The PTEN/Cowden clinic is directed by Charis Eng, MD, PhD, and Kaitlin Sesock, MGC, LGC, is the genetic counselor coordinator.
GMI houses the world's only PTEN Multidisciplinary Clinic, which provides specialized care and visit coordination for patients with PHTS. This rare genetic disorder predisposes patients to increased risks for multiple kinds of cancers as well as neurodevelopmental disorders such as autism. A trip to GMI to see our PTEN Clinic team provides evaluation and guidance from specialists who have experience caring for many patients with the same rare condition. Many patients have also had the opportunity to participate in on-site clinical research opportunities, enabling them to directly contribute to the scientific knowledge of their rare condition.
Southwest's generosity is based on financial need, and provides PHTS patients and their caregivers travel assistance to Cleveland for the specialized services CPGH provides.
Micheala Aldred, PhD, Associate Staff in the Genomic Medicine Institute (GMI), has been awarded a new grant entitled "Nonsense Readthrough: a Therapeutic Approach to Inherited Vascular Disorders" from the National Institute of Health, National Heart, Lung and Blood Institute (NIH, NHLBI), for a total of $1.6 million over four years.
Dr. Aldred's lab will evaluate a new therapeutic approach known as nonsense readthrough, testing two drugs that may be able to correct genetic defects in an important cell-signaling pathway. Mutations in this pathway can lead to two serious disorders affecting the blood vessels, hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH). The long-term goal of this study is to identify new therapies for inherited vascular diseases, leading to future clinical trials and the possibility of personalized therapy based on the type of genetic mutation.
Angela Ting, PhD, and her research team at the Genomic Medicine Institute (GMI), have identified a unique signature for aggressive prostate cancer and are developing a diagnostic test based on this signature to assist in clinical decision-making. The findings were recently published in the journal Cell Reports. According to Dr. Ting, this study of DNA methylation patterns not only advances our understanding of the development of prostate cancer, but may eventually lead to enabling prevention.
Prostate cancer continues to be a serious healthcare problem with approximately 220,800 new cases reported in the United States in 2015. Researchers say distinguishing slow growing from aggressive prostate cancers may allow patients with aggressive cancers to receive potentially life-saving treatments. Conversely, patients with slow growing cancer could avoid unnecessary treatments and side effects.
Brandie Leach, MS, LGC, was recently honored to accept the Colon Cancer Alliance Sapphire Award in Phoenix, AZ. Brandie accepted the award on behalf of a large team of Cleveland Clinic caregivers from the Digestive Disease Institute (DDI), Taussig Cancer Institute, and the Center for Personalized Genetic Healthcare (CPGH) in the Genomic Medicine Institute. The team was lead by Dr. Matthew Kalady from the DDI. Other CPGH team members included Jessica Marquard, MS, LGC and Jill Polk, MS, LGC.
This award was given in appreciation of the team's successful organization of the inaugural "Cleveland Undy", held last spring. The Undy Run/Walk is a unique family-friendly event created by the Colon Cancer Alliance, where participants are encouraged to dress up in underwear to spark important conversations about colon cancer, the second leading cause of cancer death in the U.S. The local event helped to raise over $17,500, a portion of which will remain in the Cleveland area to support screening and awareness events.
Charis Eng, MD, PhD, and her research team, have discovered a new gene variant associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other types of cancers, including a subset of non-inherited thyroid cancers. This discovery was recently published in the American Journal of Human Genetics.
"The discovery of these new cancer-predisposing gene variants will facilitate predictive genetic testing, risk assessment, genetic counseling, and clinical management of the disease," said Dr. Eng.
Details about this important discovery:
HemOnc Today
Researchers identify new cancer-predisposing gene associated with Cowden disease
Genome Web
Cowden Syndrome Study Uncovers Mutant Gene With Ties to Sporadic Thyroid Cancer
Story also highlighted on the Cleveland Clinic website:
Health Essentials
Researchers Discover Gene Has Link to Thyroid, breast Cancers
Full journal publication here:
American Journal of Human Genetics
Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer
We've all heard of personalized health care, in which a treatment can be right for one patient and not for another. But what is precision medicine? Explore the recent Cleveland Plain Dealer Op-Ed, Treating cancer with precision medicine and genetic evaluations, featuring Charis Eng, MD, PhD; J. Kevin Hicks, PharmD, PhD; and Joanne Ngeow, MBBS, MRCP, MPH.
The Genomic Medicine Institute (GMI) celebrated the10th anniversary of the Center for Personalized Genetic Healthcare at it's 3rd annual Genetics Education Symposium entitled "Genetics and Genomics: Integration into Clinical Practice," (CME Course Director Charis Eng, MD, PhD, founding Chair of the GMI and founding Director of the Center for Personalized Genetic Healthcare) held at the InterContinental Hotel in Cleveland. The day-long symposium, which was attended by over 150 healthcare professionals and students, continues to grow and generate significant interest in the field of genomic medicine.
This year a variety of engaging presentations were delivered, including: Referring Patients to Genetic Counseling/Testing by Daniel Sullivan, MD, Principles of Pharmacogenomics by Kevin Hicks, PharmD, PhD, History and Progress of Medical Genetics by Timothy Moss, MD, Tumor Genetic Profiling by Davendra Sohal, MD, MPH, and a spirited panel discussion on the Reimbursement of Genetic Testing with Stephen Lucht, MD, Jacqueline Riley, MS, LGC and Bruce Rogen, MD, MPH.
"Precision medicine is like anything else. The biggest enemy is the bureaucracy"
Dr. Tony Wynshaw-Boris, Chair of the Department of Genetics and Genomic Sciences at Case Western Reserve University, delivered the keynote address: "Chromosome Therapy: Rescue of Ring Chromosomes by Cellular Reprogramming."
GMI appreciates the generous sponsorship provided by Appistry, CompanionDx, Counsyl, GeneDx, Genzyme, Invitae, Myriad, Personalis, Pfizer, Sequenom and Shire.
The Center For Personalized Genetic Healthcare (CPGH) will be well-represented at the National Society of Genetic Counselor's (NSGC) annual meeting this fall! Allison Schreiber, MS, LGC, genetic counselor within CPGH, was selected for Best Full Member Abstract for "Assessment of complexity among cancer, cardiovascular, general pediatric/adult, and prenatal genetic counseling at a single institute: a tool to improve efficiencies and help guide patient volumes."
NSGC expert reviewer comments included, "Your study does a marvelous job of exploring the issue of what is a fair caseload across the subspecialties of a clinical genetic counseling practice," and "This study will aid clinic managers tremendously. It is well organized and well executed."
In addition to this award, additional CPGH genetic counselors will be represented at the meeting. Jessica Marquard, MS, LGC will be presenting a platform, Brandie Leach, MS, LGC, and Marissa Smith, MS, LGC are speakers, and Brittany Psensky, MS, LGC, Ryan Noss, MS, LGC and Christina Rigelsky, MS, LGC will be exhibiting posters.
Congratulations to all!
Congratulations to three faculty members of the Genomic Medicine Institute (GMI) on their recent promotions. David Serre, PhD, Angela Ting, PhD, and Bin Zhang, PhD, have all been promoted from Assistant Professor to Associate Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine. These appointments represent a major landmark in their academic careers and we wish them continued success.
GMI is pleased to announce that Charis Eng, MD, PhD, and Kevin Hicks, PharmD, PhD, will be the national coordinating investigators for UPGRADE (Utility of PharmacoGenomics for Reducing Adverse Drug Effects). UPGRADE is a multicenter registry sponsored by CompanionDx™ that includes up to 279,000 patients enrolled at up to 2,000 clinical sites.
The primary objective is to assess whether pharmacogenomics testing leads to clinically meaningful changes in a patient's medication regimen.
"This exemplifies how academic-private partnerships can rapidly achieve meaningful translational research to support the practice of precision medicine," said Dr. Eng.
Congratulations to Pauline Funchain, MD, an Ambrose Monell Clinical Cancer Genomics Fellow in the Eng Lab who received a 2015 Conquer Cancer Foundation ASCO Merit Award. This award recognizes exceptional scientific merit of research conducted by oncology fellows and residents early in their careers, and encourages attendance at the annual American Society of Clinical Oncology (ASCO) Meeting. Pauline attended the Chicago meeting in June to present her abstract titled "Hereditary Implications of Somatic Tumor Testing."
GMI is pleased to announce that Amanda Tilot received the 2015 Doctoral Excellence Award in Molecular Medicine from the Case Western Reserve School of Medicine. This award was established to recognize outstanding graduate students in PhD programs. Successful recipients exhibited exceptional qualities in research, scholarship, service and collaboration.
Amanda earned her PhD in Dr. Charis Eng's lab, and has accepted a postdoctoral position at the Max Plank Institute for Psycholinguistics in the Netherlands, beginning in May, 2015.
Dr. Charis Eng, who received her MD and PhD degrees from the University of Chicago, was presented with the 2015 Distinguished Service Award at the Alumni Awards Reception in Chicago. This award, presented by the University of Chicago Biological Sciences Division and the Pritzker School of Medicine, recognizes alumni who have brought honor and distinction to the Division of Biological Sciencesz/Pritzker School of Medicine and to the University of Chicago by demonstrating outstanding leadership in and making significant contributions to the biological sciences or medicine through research, clinical care, health service administration, public and professional service, or civic duties.
Ron Rerko, Director, Translational Development, was invited to participate on a panel at the MidAmerica Healthcare Venture Forum held in Chicago in May, 2015. MedCity Media and Mid-America Healthcare Investors Network (MHIN) connected investors with corporate business development executives to highlight investment opportunities with promising start-up companies. The panel examined recent and anticipated innovation in the fields of genomics and personalized medicine, as well as promising areas for investment.
The Genomic Medicine Institute (GMI) and the Center for Clinical Genomics are excited to announce a broad research collaboration with Human Longevity Inc., (HLI), Dr. J. Craig Venter's company in San Diego, CA. HLI is using genomic sequencing, the human microbiome, proteomics and advanced computing to tackle aging-related human diseases. Under the master agreement negotiated by Dr. Charis Eng, Chairperson, GMI, the initial project is in collaboration with Drs. Wilson Tang and Stan Hazen of the Cleveland Clinic to discover new disease-causing genes and disease pathways associated with heart disease. Read the Story
Dr. Eng notes a great deal of potential moving forward to collect and sequence thousands more samples. "Cleveland Clinic has these precious samples of DNA linked to well-annotated clinical information, and Human Longevity has the firepower with lots of the newest, most cutting-edge sequencers." Dr. Tang also emphasizes the importance of this joint venture as a major step in building the infrastructure for clinical genomic medicine. "This unique opportunity brings clinicians and researchers from all disciplines to tackle some of the biggest challenges in our daily clinical practices using these powerful yet sophisticated technologies. We are hopeful that this also brings us a step closer to applying these tools at the bedside."
Charis Eng, MD, PhD, Hardis Chair of the Genomic Medicine Institute (GMI) and Director of its clinical arm, the Center for Personalized Genetic Healthcare, was recently interviewed by 19 Action News on the topic of "BRCA Testing: Am I at Risk?". Actress Angelina Jolie recently brought this particular genetic screening for breast and/or ovarian cancer to the forefront. After testing positive for a BRCA1 mutation, she chose to have a double mastectomy and eventually had both her ovaries and fallopian tubes removed. The measures she chose were all in the name of being proactive, supported by research evidence, which Dr. Eng feels very strongly about.
Her advice for anyone who is concerned about their risk is to craft an accurate and thorough family health history and speak with a geneticist or genetic counselor. Genetic counselors are trained to help you determine which screenings may benefit you and protect your future health. Dr. Eng believes that too much inappropriate testing of women without the clinical red flags that denote increased inherited risk of cancer is dangerous. She worries that it can yield too many false positive or false negative test results, creating either unnecessary emotional turmoil or unwarranted relief, when there really should be extra attention and care.
"The more we abuse testing in the wrong situation, the more expensive it will be . . . we have to be good stewards of good genetics practice." In the future, BRCA1 and BRCA2 screening may become a routine part of care once you reach a certain age, but Dr. Eng feels our system is not yet ready for mass testing. In the meantime, taking preventative steps like family health histories and genetic counseling can protect more women from cancer.
We are proud to announce that Brandie Leach, MS, a Licensed Genetic Counselor in the Center for Personalized Genetic Healthcare (CPGH), the clinical arm of the Genomic Medicine Institute, was elected President of the Collaborative Group of the Americas on Inherited Colorectal Cancer. This group aims to advance research on several rare forms of inherited colorectal cancers, as well as improve clinical care for patients and families affected by these diseases.
Ms. Leach specializes in cancer genetic counseling and this appointment marks the first time a genetic counselor has been elected President of this group. Genetic counselors are healthcare professionals with specialized training in medical genetics and counseling.
Angela Ting, PhD, a Principal Investigator in the GMI, led the Lerner Research Institute's (LRI) second annual "LRI Science Day" for students from Citizens Leadership Academy (CLA), a local charter school. Students in grades 6-8 were asked to submit a contest entry in the form of an essay, drawing, poem or photograph about their interest in science and medicine. From this competition, 50 students were invited to attend.
Fellow GMI personnel also took an active role in this popular event. David Serre, PhD, spoke on his beginnings in science and the state of the Cuyahoga River, while Jessica Mester, MS, Licensed Genetic Counselor, spoke to a group on genetic inheritance. Competitive DNA extraction was also performed by research technologists Todd Romigh, MS, and Sirena Meade, MS and PhD candidate Lamis Yehia, MS.
GMI is proud to be a part of this outreach program, which encourages students from underprivileged backgrounds to pursue a career in science, while raising awareness in our surrounding communities of the diverse and exciting research going on in LRI and CCF. Dr. Ting explains that many scientists and physicians say they became intrigued by science at an early age, and she hopes this program will foster that interest in young children. "Different kids are fascinated by different things – we try to give them a broad, hands-on experience, and we hope to connect with them."
The Lerner Research Institute's Genomics Core, under the scientific direction of Charis Eng, MD, PhD, has been awarded a $600,000 NIH Shared Instrumentation Grant (Dr. Eng is the PI on the grant) to significantly upgrade its next generation sequencing capabilities.
Charis Eng, MD, PhD, Genomic Medicine Institute Chair, recently published a paper in the Journal of Clinical Oncology entitled "Second Malignant Neoplasms in Patients With Cowden Syndrome With Underlying Germline PTEN Mutations."
Micheala Aldred, PhD, Genomic Medicine Institute, was invited to be the "featured speaker" and conclude the session on Epigenetics in Pulmonary Hypertension: Novel Mechanisms and Targets at the 2014 American Thoracic Society Conference. Dr. Aldred's presentation was entitled "Epigenetics: A changeable landscape."
Amanda Tilot, doctoral student in the Molecular Medicine program, was named the winner of the F. Merlin Bumpus Junior Investigator Award. This award highlights excellence in research by graduate students and postdoctoral fellows in both basic science and clinical areas.
The Friends of the LRI event highlights discoveries and innovations in treating specific disease areas and provides a unique opportunity to engage one-on-one with some of the world's leading scientists.
Charis Eng, MD, PhD, Chair of the Cleveland Clinic's Genomic Medicine Institute and Thomas Frazier II, PHD, Director of the Children's Hospital Center for Autism are working to investigate autism and genetic related factors. Dr. Eng has discovered a gene mutation that predisposes people to certain kinds of cancer that can also be linked with autism. To learn more about this exciting research, watch interview here.
Dr. Charis Eng has achieved much during her busy life. Being a woman in the field of medicine and medical research has not always been easy, especially when it comes to being mentored.
Lerner Research Institute
Cleveland Clinic,
Mail Code NB21
9500 Euclid Avenue
Cleveland, Ohio 44195
Tel: (216) 444-3900


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Friday, March 28, 2014
Due to the high probability of severe thunderstorms this weekend, the 24th Annual Folly Beach Sea & Sand Festival & Fundraiser has been postponed to the weekend of April 11-13.
The projected schedule of events will remain the same.
If you have questions regarding the date change or further details of the weekend's events, contact festival director Ben Bounds at 843-408-6439 or firstname.lastname@example.com.
This annual event is Folly Beach's longest-running, largest and most family-friendly festival and fundraiser. The event is put on each year to raise funds for the Folly Beach Parks & Recreation Department. On Friday the event kicks off with the first annual Miss Sea & Sand Festival Pageant. The pageant will take place at Folly River Park from 7 - 9 p.m. The festival continues on Saturday with the ESA Tides Kickoff Classic Surf Competition and the Coffin Island 5k. Then the street party begins at 10 a.m. on Saturday and will feature local food and art vendors, a silent auction, live music, jump castles, face painting, special celebrity guest Reggie Kelly and so much more. Musical performances include: Rollin' in the Hay, Weigh Station, Guilt Ridden Troubadour, 54 Bicycles, Rusty Hook and more. Sunday, March 30 concludes the Sea & Sand Festival with the finals of the ESA Tides Kickoff Classic Surf Competition, the annual Sand Sculpting Contest and East Coast Party Band finale concert. Tickets and entry prices may vary for each event, please go to www.visitfolly.com, find us on Facebook at Visit Folly or download the Visit Folly mobile app for all the details.
© 2016 Moultrie News an Evening Post Industries company. All Rights Reserved.
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TCI Transmission Pressure Gauges
These pressure gauges are available with either a silver or black face and come with both red and green light covers for clear backlighting. These 2-5/8" gauges fit in or under nearly any dashboard and have a 0 to 300 psi range. Best of all, these kits feature easy-to-install sensor adapters and work with any automatic transmission.Features
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Find. Book. Pitchup.
- We make it a doddle to book campsites, glamping sites and caravan parks throughout the UK, Europe and the Americas.
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Caffeine-producing plants use three different biochemical pathways and two different enzyme families to make the same molecule.
When Does a Smart Mouse Become Human?
July 1, 2015|
Ethical issues attend the creation of animal-human chimeras.
July 1, 2015|
Ethical issues attend the creation of animal-human chimeras.
June 17, 2015|
Around one out of every four cancer papers scrutinized in a recent study contains questionable figures, and journals and authors aren't responding to requests for clarification.
June 1, 2015|
The number of plagiarism-based retractions has grown since the advent of detection software, according to a BioMed Central analysis.
May 20, 2015|
Research participants aren't always clear on open data policies when consenting to studies.
April 30, 2015|
Following the publication of a study in which scientists used CRISPR to edit nonviable human embryos, the National Institutes of Health states it will not fund such research.
April 28, 2015|
Embryo editing edition
April 2, 2015|
The university is among defendants listed on a lawsuit filed this week by participants in controversial experiments conducted in Guatemala in the 1940s.
March 13, 2015|
In response to speculation that groups have edited the DNA of human embryos, researchers request that gene editing of human reproductive cells be halted.
December 16, 2014|
Staff of the blog Retraction Watch will create a database of papers retracted from the scientific literature.
December 1, 2014|
As new technologies emerge, we must choose our words for them with care: names can negatively bias the inevitable debates over the ethics of scientific advances.


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Our Chapter Passed £493,650 in the past 12 months!
BNI members, on average, increase their business 20% the first year. Our chapter is a dynamic, committed group of business people who know how to refer business to each other.
We have open categories for individuals who will bring enthusiasm and integrity to our meeting. Just one person per professional specialty is allowed in each chapter.
Search our members here to see if your category is open, then visit a meeting and lock out your competition!
Come for our meeting - stay for the referrals!!!
Meeting Date : Meeting Speaker, Meeting Topic
10/05/2016 : Janita Maaranen, Shake4Energy
10/12/2016 : Paul Rodgers, Cowens Financial
10/19/2016 : Jon Harvey, Carsave UK
10/26/2016 : Kathleen Bulmer, NotJustTravel


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Public Image Ltd
~ Group
Public Image Ltd (also known as PiL) are an English post-punk band formed by singer John Lydon (aka Johnny Rotten), guitarist Keith Levene, bassist Jah Wobble, and drummer Jim Walker. The group's personnel has changed frequently over the years; Lydon has been the sole constant member.
Lydon emerged after the break-up of the Sex Pistols with PiL's Public Image: First Issue (1978). The new band had a more experimental sound than the Pistols: a "droning, slow-tempo, bass-heavy noise rock, overlaid by Lydon's distinctive, vituperative rant". Their early work is often regarded as some of the most challenging and innovative music of the post-punk era. Their 1979 album Metal Box was ranked number 469 on Rolling Stone magazine's 2003 list of the 500 greatest albums of all time. The NME described PiL as "arguably the first post-rock group".
Showing official release groups by this artist. Show all release groups instead, or show various artists release groups.


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"Influenced by Foo Fighters, Blink 182 and other American bands like them, Israel's Random Dogs is an emerging rock group that just played their first US gig, the Driven Music Conference here in Atlanta last month. Our December Track of the Month, "Over The Edge" is the leading song from their debut EP, an uptempo and aggressive 5-track effort"
"The Canadian blogger Michael Trike McGrath chose 3 songs and bands from Israel he love the most. Random Dogs are listed there as well."
"Ben Rayzman, lead vocalist of Random Dogs Interviewed for "Young Creator's Corner" at "103 FM" (1 of the 3 biggest radio stations in Israel)"
"Music.co.il - One of the biggest music sites on Israel titled our song "Old True Love" as "one of the best Israeli songs 2012""


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News and notes on the restaurant scene from dining critic Carol Deptolla
Vinamo, a wine bar with small plates, to open in Whitefish Bay in August
When Rosemarie Niles opened a frozen yogurt shop with her husband in DeLand, Fla., last year, she soon discovered the tapas place across the street and the wine bar next door. Now she's combining the concept of both in Vinamo, a wine bar and small-plates restaurant at 402 E. Silver Spring Drive in Whitefish Bay.
Vinamo is expected to open in August.
"I love wine, I love small-plate dining, too," Niles said. "It makes the whole dining experience more enjoyable" because it encourages guests to share, linger and talk about food. »Read Full Blog Post


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Helping people. Saving gorillas.™
Many travelers enjoy combining a visit to the gorillas with other activities in the region such as game viewing in Kenya. Our experienced trip specialists at Terra Incognita Ecotours have designed a unique program to visit this beautiful region. Please visit the Terra Incognita website for more information. You may also fill out this information form and return to the Terra Incognita team at firstname.lastname@example.com to express your interest. Please be sure to mention the Fossey Fund in the "How did you hear about us?" section. With every confirmed booking at Terra Incognita, we receive a donation. For more travel information, please contact the Fossey Fund at firstname.lastname@example.com.
No experience is required, but in order to fully enjoy the trip's activities, trip participants should be reasonably fit, in good health, and have a spirit of adventure. Gorilla trekking in thick jungle at elevations ranging up to 10,000 feet can be tough, arduous and wet, and often includes hiking over uneven terrain and through dense brush. Please be sure to wear a sturdy pair of hiking boots while gorilla tracking and expect to walk at least 3-5 miles. Please note that Rwandan law does not allow anyone under the age of 15 to participate in gorilla trekking. The law is strictly enforced for the safety of the gorillas.
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We offer high-quality, competitively priced educational programs throughout the year. Whether face-to-face or online, our programs give you the chance to learn and network.
Whether you're selling a practice, looking for space, or pursuing new opportunities, look no further than our CDS dental classifieds, which receive more than 100,000 online views annually. Ads are also published in the CDS Review, the official magazine of the society.
Network with your colleagues and
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Informing members of the latest issues in dentistry is our mission. While we cover issues of national importance to the profession, we focus on news that affects our region and local communities.
Come to Chicago Feb. 23-25 for the 2017 Midwinter Meeting.
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A tradition of working for the dental profession. The Chicago Dental Society was organized in 1864 and incorporated in 1878. The objective of the Chicago Dental Society is to encourage the improvement of the health of the public, to promote the art and science of dentistry and to represent the intrest of the members of the profession and the public that it serves.
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SureCAL was developed by calibration engineers and technicians determined to cut the high cost of manually calibrating and maintaining test and measurement equipment. SureCAL has TEGAM drivers and procedures that will allow you to automate and streamline your TEGAM Power Sensor Calibation System. SureCAL Test Manager for Windows makes testing easy and practical with "flexible standards". Flexible standards means SureCal procedures were developed for standards that meet the minimum testing requirements. This allows the operator to use equipment already in the lab from manufacturers like Anritsu, Fluke, Hewlett Packard(Agilent), Keithley, TEGAM, and many others. SYSII-SureCAL includes more than 30 predefined power sensor profiles. With the easy to edit "Test Profile" for power sensors, that list can be expanded to include just about any commercially available power sensor! This package includes the ability to read and update the cal factor tables of most Anritsu, Agilent (both E4400 and E9300 series), Boonton, and Giga-tronics power sensors.
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D A. Dhoble ,Scientist, National Chemical Laboratory, Pune
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One problem, though: Its keepers are bogarting the good stuff.
The Portland Police Evidence Warehouse, at 2619 Northwest Industrial Street, is where your precious weed and beloved bong Big Thunder go to live when the cops kidnap them. Even being a medical-marijuana card holder won't get your green back—former Attorney General John "Reedie Stomper" Kroger issued a memo saying federal law allows the local 5-0 to hang on to your stuff, even when your glaucoma is flaring up and you're in terrible pain.
Bummer. WW scheduled visiting hours with the headiest, dankest and greenest items in the evidence warehouse. They'll remain here until trial, after which they'll be destroyed "as soon as possible."
1. Submachine Gun Pipe
Getting high is one thing, but putting the business end of a machine-gun-shaped pipe in your mouth is something else. According to police, that's what a suspect identified as "Shorty" was doing when officers Schroeder and Lance strolled up on him and his friends hanging out on the sidewalk near Southeast Pine Street and 11th Avenue one Saturday night. He put the gun down, but the clink of glass on concrete set the officers' ears on edge. "Please don't take my weed!" Shorty reportedly begged. His whole stash was eventually confiscated, including a bag with just eight buds and a small container of "shake marijuana." As police gathered the evidence, according to the report, the gun was still smoking.
2. Lights and Ballasts
Grow rooms require a lot of gear. And when they get busted, the cops get that gear. "We have hundreds of these lights and ballasts, and they're all worth a couple hundred bucks each," says Dave Benson (pictured), manager of the Portland Police Bureau's evidence stash. On Craigslist, the cops could turn a tidy little profit with these rigs. But putting them at a public auction would probably lead to continued use by marijuana growers. So, instead, the cops allow the state to buy them. "These sales aren't advertised widely, only to government agencies with a legitimate use—an elementary school for example," says Benson, adding the schools are "well aware that they come from illicit sources." To date, only 10 lights, three ballasts and two fans have been sold for a total of $250. What to do now? "Maybe we can sell them to Washington," Benson says.
3. Weed Vault
In the back corner of the evidence warehouse is the highly guarded treasure room of this palace, lined top to bottom with green gold. Cops call it "the weed vault." Two members of the staff must simultaneously tag their IDs in order for the doors to open, and as a rule there must always be a 1-to-1 ratio of police to visitors. The vault contains "thousands of plants and thousands of pounds of marijuana," Benson says. Rows of plants hang upside down in burlap sacks, just as in a meat locker. Fans circulate the air, just like they would in a grow operation, because the mold is deadly. A 15-foot-high wall—located directly opposite a crate of handguns—is stacked with large vacuum-sealed bags of dried weed, which are torched by a Salem incinerator three times a year. "We burn it as often as we can," Benson says. âIt just doesnât stop.â
4. Adorable Frog Bong
This bong, featuring a small tree frog clinging to the bowl, was the most aesthetically pleasing we found. Its alleged former owner, though, is a juvenile, so the police report cannot be released. A tipster told us the bong was probably the work of Eugene's highly respected Special K Creations, whose bosses were not available for comment. A sharp-eyed employee at House of Pipes on Northeast Broadway says it's probably a knockoff. "It would have to have a special engraving around the top," says a tobacco-pipe salesman. "It looks like a Chinese imitation to me.â


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