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A sentencing hearing for a former Shelby County Public Schools payroll manager charged with embezzling more than a half million dollars has been moved to October.
Judge Charles Hickman set Oct. 21 as the new date for Benita Anglin due to her illness.
Anglin had pleaded guilty to the theft in August, a week before her jury trial, a move that was not connected with any plea agreement. Instead, she made an open plea, in which the person charged pleads guilty to the charges and the judge will make the decision concerning the sentence.
Jenny King of Shelby County, a former longtime finance officer for Shelby County Fiscal Court, charged with embezzling more than $23,000, has received a new court date of Oct. 21.
King, charged with stealing the money from the county's general fund over an 18-month period from April 2013 to December 2014, received the new hearing date at her status hearing in Shelby Circuit Court on Monday.
Theresa M. Augustine, a former assistant administrator and firefighter who was indicted in February 2015 on theft-related charges, will be sentenced in Shelby Circuit Court today.
Augustine pleaded guilty in July to the original charges – theft by unlawful taking $10,000 or more, but less than $100,000 – as well as abuse of public trust in connection with that amount.
Both charges are Class C felonies, which carry a prison sentence of 5 to 10 years each.
An employee of the Shelbyville Rural King has been arrested for a large theft from the store.
Christina Allen, 32, of Shelbyville was arrested Tuesday at the store at 3 p.m.
She was charged with theft by deception under $10,000 and taken to the Shelby County Detention Center, where she has bonded out.
A Shelbyville Police report said that Allen, who is the store's customer service manager, is accused of taking $1,987 from the store in a two-month period, from July to August 2016.
Robert A. Richardson, 36, of 549 Morris Clark Road in Waddy was arrested August 3 on Clubhouse Drive and charged with operating a motor vehicle under the influence of alcohol or drugs, second offense, possession of an open alcoholic beverage container and failure to produce an insurance card.
Andrew Kyle Duncan of 9204 Cedar Haven Drive in Louisville was arrested Aug. 7 on I-64 and charged with operating a motor vehicle under the influence of alcohol or drugs and careless driving.
Police are asking for the public's help to get information connected with the theft of a tractor from the John Deere dealership on Taylorsville Road.
The theft occurred shortly after midnight Friday when a Dodge pickup truck pulled into the dealership. Then, 17 minutes later, a John Deere tractor was hooked up to a trailer.
The pickup, shown in the photo supplied by video surveillance, was occupied by two white males.
Maj. Jason Rice with the Shelby County Sheriff's Office said he has no further description of the occupants of the pickup.
Tyrran M. Harris, 27, of 803 Indian Ridge was indicted for first-degree trafficking in a controlled substance (Fentanyl), first-degree trafficking in a controlled substance (cocaine), being a persistent felony offender, third-degree assault, tampering with physical evidence and promoting contraband.
Jose Edgardo Funes, 59, of Louisville was indicted for bail jumping.
Kenneth E. Cocanougher, 43, of 164 Hazel Lawn Drive was indicted for theft by unlawful taking $500 or more but less than $10,000.
Christopher Lee Kelly, 30, of 923 Cranbourne Grange was arrested July 12 on Boone Station Road and charged with operating a motor vehicle under the influence of alcohol or drugs, second offense, speeding and reckless driving.
Ashley A. Haggard, 29, of 912 Bland Ave. was arrested July 18 on Prospect and charged with operating a motor vehicle under the influence of alcohol or drugs.
A man who has been incarcerated in Shelby on murder charges for more than a year was formally sentenced in Shelby Circuit Court Monday on vehicular manslaughter and related charges.
Miroslav Kuzmanovic, 24, of Washington state, listened stoically as Shelby Circuit Judge Charles Hickman handed down a 10-year sentence in accordance with a plea agreement that Kuzmanovic had made with prosecutors just hours before a jury was to be selected for his trial in June for the murder of Doris Wise.
Justino N. Carreno, 58, of 306 B St. was arrested May 28 at B Street and Marshall Court and charged with operating a motor vehicle under the influence of alcohol or drugs, first offense, possession of an open alcoholic beverage container in a vehicle and operating a vehicle on an expired license.
Ralios C. Gaspar, 34, of 304 Frankfort Road was arrested May 28 on Main Street and charged with operating a motor vehicle under the influence of alcohol or drugs, first offense, careless driving and no operator's license.
Copyright © 2016
The Sentinel-News is your source for local news, sports, events and information in Shelby County and Shelbyville, KY, and the surrounding area.


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Shifting to one-stop shopping
March 21, 2006
Within retail trade, food and beverage stores and general merchandise stores together accounted for more than 1 in 3 jobs. Employment trends in these two industries can have profound effects on the industry as a whole.
Employment in food and beverage stores has declined steadily since reaching a peak in April 2000, falling by 164,600, or more than 5 percent.
By contrast, employment in general merchandise stores has expanded. From an employment trough in October 2002 to May 2005, the general merchandise industry added 78,700 workers, nearly a 3-percent increase. Notably, the industry has fully recovered the jobs lost during its previous employment downturn (December 2000 to October 2002) and employment is currently expanding.
Since the implementation of the North American Industry Classification System (NAICS), general merchandise stores are broken down into two main categories: department stores and other general merchandise stores. The category of other general merchandise stores contains the warehouse clubs and supercenters industry.
Much of the reason for the turnaround in the general merchandise industry is the emergence of the warehouse clubs and supercenters industry—this relatively new industry has experienced robust growth in recent years.
These data are from the BLS Current Employment Statistics program. For additional information, see "From supermarkets to supercenters: employment shifts to the one-stop shop," by Michael H. Strople, Monthly Labor Review, February 2006.
Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Shifting to one-stop shopping on the Internet at http://www.bls.gov/opub/ted/2006/mar/wk3/art02.htm (visited October 01, 2016).
Recent editions of Spotlight on Statistics
A look at healthcare spending, employment, pay, benefits, and prices
As one of the largest U.S. industries, healthcare is steadily growing to meet the needs of an increasing population with an increasing life expectancy. This Spotlight looks at how much people spend on healthcare, current and projected employment in the industry, employer-provided healthcare benefits, healthcare prices, and pay for workers in healthcare occupations.
Employment and Wages in Healthcare Occupations
Healthcare occupations are a significant percentage of U.S. employment. Some of the largest and highest paying occupations are in healthcare. This Spotlight examines employment and wages for healthcare occupations.
Fifty years of looking at changes in peoples lives
Longitudinal surveys help us understand long-term changes, such as how events that happened when a person was in high school affect labor market success as an adult.

subset: commoncrawl


text: Unfortunately, due to hosting problems, the images on the site all appear to have been lost. We are working to rectify this problem. Our hosting provider has recently been bought by another company and there appears to be several glitches in the transfer. We are trying to get the matter resolved. All the posts are here, but the images aren't. Please feel free to visit the Facebook page for images


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With wide open verandahs over looking the marina, bars and restaurants at your doorstep, shops galore and a short walk to beautiful Main Beach, Surfers Paradise YHA at Main Beach is the perfect hostel for non-stop fun in the sun! The hostel offers daily free shuttles into the heart of Surfers Paradise, nightly activities including pub crawls, movie nights and barbecues on the deck. Facilities include multi-share, twin and double rooms, communal kitchen, wi-fi internet throughout and free wi-fi hotspot - everything needed for travelling on a budget.
Enjoy thrill rides, water slides, or wildlife; there are more attractions here than any other destination in Australia. With 70 kilometres of white sandy beaches and 100,000 hectares of world heritage-listed rainforest, there is so much to explore. The friendly tour desk staff can take care of your tour and travel bookings for the rest of your journey. There are loads of water sports departing just a few metres from your door. Take a jet boat ride, learn to surf or just relax - it's up to you!
Note: Information on listed products and services are provided by the operator and were correct at the time of publishing. Rates are indicative based on the minimum and maximum available prices of products and services. Please visit the operator's website for further information. All prices quoted are in Australian dollars (AUD).


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There is a moment when you stagger back into your home after five days in a field, and the concept of carpeted floors just looks… strange and alien. Maybe it's tiredness, or the tendency of the human brain to adapt
Gone Larping. Back Tuesday.
Work I pushed a thing live. It took 12 hours, I'm still fixing bugs in it, but it's there, a new base to start from, and nearly five months work. It could have gone better, but there are ways it
Code starts in a text editor. Your text editor might be a full IDE, custom built for your language, a vim window with more commands than you can remember, or an emacs with more metakeys than you have fingers. Nowadays,
It wasn't until about four hours in that I heard it first. The triggers for it aren't the same as previous games, it's more forgiving in that respect at least, but attempting to get out of an underground maze: You
I used to do this kind of thing monthly in WRP format. It's as good as any: Work: Skute's in the wild, to some extent. Beta invitations have been sent out – the demons of the Play Store beta system are
"No one is actually dead until the ripples they cause in the world die away…" ― Terry Pratchett, Reaper Man I'm rarely out of words, but today's one of those. It's around 20 years since I wondered why everyone kept
New Apple announcement looks interesting. Handily, the new Macbook will been in second revision about the same time I'm looking to upgrade my work MBA, I'm impressed they got a high-res display into a fanless thiner-than-air case without too much
The previous MTOL were in 2004 and 2007, and soon I'm going to get over this "I've been doing this too long" kick. Organisation Google & Omnifocus, mostly. My email is google-app based, although most of my interface with it is


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Friday, January 17, 2014
After many years of age and wear, The Fighting Lady is getting a much-needed face-lift. In a project expected to last about eight months, Patriots Point operations personnel are painting the starboard side of the ship. It's the first time the hull of the ship has been painted since the mid-1990's.
With a price-tag of around $190,000, the job- which will take some 500 gallons of paint- is funded through admissions, gift shop sales, overnight camping and event rentals. Patriots Point does not receive appropriated funding for operations.
The first priority is to complete the starboard side hull from the main deck down to the water. Patriots Point will request funds from the Patriots Point Development Authority board in the next fiscal year budget to paint the port side of the ship.
"We're doing this job as efficiently as we can," Patriots Point Operations Director Bob Howard said. "To clean the ship to bare metal and apply a new coating system would cost well over $3 million. While that's ideal, funds that large simply aren't available. We chose an alternative that would help preserve the metal and make the ship look better for a few years while we identify the funding needed for the long-term solution," Howard added.
After discussions with state regulatory agencies, it was determined a sufficient method is to lightly remove the flaking paint and scale, without sanding or grinding, then apply a primer and top-coat to the steel.
"By using our crews to do this work we are saving hundreds of thousands of dollars," Patriots Point Executive Director Mac Burdette said. "She will shine when our guys are finished," he added.
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Johnny Depp Shows His Bloody Hand in New 'Dark Shadows' Set Photo
A new set photo from Tim Burton's "Dark Shadows" has been unveiled via Empire. In the image, Johnny Depp is seen showing off his blood covered hand while Burton stands in front of him. The actor is seen rocking his pale vampire make-up, as seen in the previous on-set picture.
There is also another new image that sees Michelle Pfeiffer as Elizabeth Stoddard and Jonny Lee Miller as Roger Collins sitting at what looks like a dinner table. Burton, meanwhile, is seen directing them from the middle.
"Dark Shadows" is set in 1972 and centers on the life of Depp's Barnabas Collins and his run-ins with various monsters, witches, werewolves and ghosts. Collins was transformed into a vampire by his lover Angelique, played by Eva Green, way back in the 1700s.
Of why Tim and Depp chose the film to be set in 1972, screenwriter Seth Grahame-Smith explained, "Tim and Johnny took a long time explaining exactly why it had to be 1972." He added, "1969 was too early and 1973 was too late."
"1972 is right at the time when the hippie movement and all its peace," Grahame-Smith went on adding. "And love is dying out and being replaced by this me-me-me generation in the '70s who are all about showing their wealth and having everything."
The movie, which marks Tim and Depp's eighth collaboration, will be firmly formed in 2D. Producer Richard Zanuck said, "We discussed this quite a bit. We didin't want to be categorized as another 3D extravaganza, because this isn't. We have action sequences, but mostly it's interaction between characters, and that's where the humor and the story come from."
Currently still in production in England, "Dark Shadows" is scheduled to be released on May 11, 2012 in U.S. theaters. The movie also stars Helena Bonham Carter, Chloe Moretz, Jackie Earle Haley, Bella Heathcote, Thomas McDonell as well as Gulliver McGrath.
- Monsters and War Unleashed in New 'Fantastic Beasts and Where to Find Them' Trailer
- Video: Kim Kardashian Ambushed by Gigi Hadid's Attacker in Paris
- Lin-Manuel Miranda Heading to 'SNL' as First-Time Host
- 'Lion King' Gets a Remake From Disney and Jon Favreau
- Robin Hood Confirmed to Return for 'Once Upon a Time' Season 6
- New David Bowie Greatest Hits Album Announced
- The Flash Reunites With Jay Garrick, Teams Up With Tom Felton's Character in Season 3 Photos
- 'Doctor Strange' IMAX Trailer Unveils Avengers Ties. Also Get Details About Rachel McAdams' Role


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Powder puffs take on demolition derby track
By Laura Collins
Published in News on October 6, 2009 1:46 PM
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Wendy Lane steers her 702 car into the mix of other female derby drivers during the Powder Puff Demolition Derby Monday at the Wayne Regional Agricultural Fair.
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Powder Puff Demolition Derby winner Wendy Lane, right, receives her trophy from 2009 Queen of the Fair Hannah Singleton Monday.
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Supplier since 1950 BATTERY MANUFACTURING EQUIPMENT
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We design, manufacture and recondition machines in our in-house facilities. Furthermore, we work closely with main international brands to offer a wide portfolio of high quality equipment for production of Lead Acid Batteries such as: Lead Oxide Production, Plate Making, Enveloping, Assembly, Charging and Recycling Equipment. We also supply a wide variety of spare parts and raw materials.
With a strong network of suppliers in the industry, Accurate Products provides intelligent equipment solutions to fulfill customer needs.
With more than 60 years of experience in the Lead Acid Battery Industry, Accurate Products represents a reliable choice when planning your next investment.
Send your inquiry to Accurate Products, and we will source the equipment or product you need.


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My Trip: Germany
Who: Jim and Marian Reim, visiting Jim's sister, Meg Roberts, and cousin, Ellen Wirtz
Where: Germany
When: Dec. 1-8
What he said: "We set off for the Christmas markets in Neustadt on Wine Street," said Jim Reim, of Erie. "We grabbed some hot wine (Gluhwein) as we admired the half-timbered buildings and stone churches. This is wine country and, just like in North East, you have to enjoy the fruit of the vine.
"As you stroll through town in Heidelberg, you cannot help but realize the 'old world' has been around for more than 1,000 years. As you climb past the stately homes to the castle at the top, you gaze at the privilege of royalty that once was.
"After a glass of bock beer at the Dom Hof, we toured Speyer, one of the larger towns in the Pfalz region of western Germany. With black roofs and medieval towers, it is not hard to imagine black knights with swords and shields on horseback.
"A tour of the Essig winery showed us how resourceful the local people are. Two drops of flavored Essig on the tongue and your mouth erupts with flavors of raspberries or figs and more. Essig is a delicious and exquisite vinegar for cooking, salads and an aperitif, and was something truly new.
"We crossed the border to see Reims, France, and the great Cathedral of Reims. This is where Joan of Arc came to fame and a site that has seen the coronation of dozens of French kings. The cathedral is so large and ornate it is, as they say, 'a bridge between earth and heaven.'
"The people of Reims celebrate in the streets. Amid decorated town squares and local Noel music, shoppers looked over candies and cheese and gifts of every kind. And like a 'Merry Christmas' in Erie, it is a 'Joyeux Noel' in eastern France and a 'Frohe Weihnachten' in western Germany."


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Chord Overstreet's Best Looks Over the Years
Loraine Pavich
| February 14, 2013 - 2:23 pm
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Supporters of Sri Mulyani now have only a slim chance of establishing a political party as a platform to nominate the former finance minister for the 2014 presidential election following a ruling by the Constitutional Court on Thursday.
They failed in their attempt to bypass the political party verification process at the Law and Human Rights Ministry after the Court ruled that the Union of Independent People (SRI) should abide by the 2011 Political Parties Law requiring all parties to have representative offices in at least 75 percent of all municipalities and regencies and 50 percent of districts in all 33 provinces.
The ruling means that the members of the party, established on May 2 this year, only have until Aug. 22 to meet all requirements after registering at the Law and Human Rights Ministry.
"The political parties law should consider the growing population. The regulation to establish branches in all regions is appropriate, and this is a requirement that should be met relatively easily by the parties," the Court ruling read.
SRI chairman Damianus Taufan called the ruling disappointing, adding that the law complicated citizens' desire to establish a political party. "This is a democratic country, but the regulation to form a party makes the process difficult and expensive," he said.
"However, we will be able to fulfill all requirements on time," he said.
Sri Mulyani served as finance minister under President Susilo Bambang Yudhoyono from 2005 until 2010. She was forced to leave the Cabinet after major political parties put pressure on the President to oust her for her liberal economic ideology and her role in the controversial Bank Century bailout. She was subsequently appointed as a World Bank managing director.
Sri Mulyani supporters, including veteran journalist and poet Goenawan Mohamad, veteran politician Abdul Rahman Tolleng, political scientist Arbi Sanit and veteran journalist Fikri Jufri, took the case to the Court.
Rahman Tolleng said he was confident as SRI's preparations were 50 percent complete.
"We still have time," he said.
Speaking after the officially registering the party Wednesday, Taufan dismissed speculation by some politicians and retired Army generals that SRI received foreign funding.
"We don't have foreign donors," Taufan, a human rights activist, said.
"The cost [to establish all branch offices] will be high. All our members work hard because some of us also donate our money," he said.
The Court previously turned down a similar request from several small political parties. (lfr)


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Urgent Care Glendale: Walk in Clinic at Northern and 43rd
Are you in need of immediate medical care for a condition that's not life-threatening, and you'd just as soon avoid the chaos of the hospital emergency room? You'll find the best in Glendale urgent care at our walk in clinic at the intersection of W Northern Ave and N 43rd Ave. We're on the southwest corner in Fry's plaza, right behind Fry's gas station. (Typhoon Car Wash is across from us on the west side of 43rd.) We're proud to serve the community, including the students and staff of nearby Apollo High School, Cortez High School, Glendale High School, and the Glendale Union High School District at large.
Founded almost a decade ago by two doctors, our line of walk in clinics challenges the status quo of urgent care centers across Arizona and Nevada. Put simply, we saw a real need in the community that wasn't being met by traditional means. Let's face it: hospital emergency rooms are overburdened, and for those in need of medical assistance, they can be their own kind of trauma. Patients in need are often subjected to excessively long wait times, a chaotic atmosphere, and perfunctory care. We felt that our neighbors looking for Glendale urgent care deserved better, and that's why we became so committed to delivering an urgent care clinic in Glendale that exceeds all expectations of what an emergency care clinic can be.
Urgent Care Services
- UCE MyLab
- Medical Weight Loss
- Physicals
- Flu Shots
- Comprehensive Medical Tests
- Low Cost Medicines
- Over the Counter Medicines
- Injuries
- Illnesses
- Primary Care Physician
When you use our walk in clinic – with or without an appointment – you can be sure you'll be welcomed by an expert staff that's deeply respectful of your pain. You've suffered an injury or a relapse of a painful condition; you don't need a lot of red tape. What you need is to feel better right away, and as the gold standard in Glendale urgent care, that's what we're committed to realizing. We have deep roots in the community, and we care about your suffering as we would about all our neighbors. We won't keep you waiting. With the absolute best in medical expertise and equipment at our disposal, we'll make sure you feel better as soon as possible.


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Mostly Lies is a true story, except for the stuff I made up. It's an essay collection of creative nonfiction and uncreative fiction.
104 backers pledged $6,197 to help bring this project to life.
Successfully raised $6,197 with 104 backers
Hi, everybody. (Seriously.)
Happy Friday. TGIF, am I right? What are you up to this weekend?
Anyway, there are 5 days left in the campaign to fund Mostly Lies... Read more
Howdy, y'all! (This time I'm serious.)
There's two weeks left in the campaign to fund Mostly Lies. Thanks to everyone who has pledged so far.
In case you missed... Read more
Howdy, y'all! (just kidding)
It's Valentine's Day and love is all around us, so I want to give you an update on what's going on with Mostly Lies. There... Read more
The first 24 hours
We're just about exactly one day into my weird book project experiment. I really had no idea what to expect, but I think it's going pretty well so far. Thanks... Read more
Project launched


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like stop trying to get a relationship out of this when i'm clearly in the drunken mistakes part of my life.
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Like yeah
Story of my month.
sounds like someone has a case of "I was drunk so it doesn't make me a greedy whore"


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Conservation requires up-to-date knowledge about the status of wildlife populations and habitat. Not only do we need to know what we've got, we also have to be able to forecast and fend off threats to our ecosystems.
Mussels provide a good example. Current conditions threaten mussels in many Missouri streams. Researchers are trying to discover the cause of native mussel decline. At the same time, they are experimenting with culturing native mussels to keep species from going extinct.
The Conservation Department maintains a research facility in Columbia to monitor and improve Missouri's forests, fish and wildlife. Its efforts are supplemented by numerous "field staff," which include conservation professionals, university students and volunteer naturalists. Its knowledge base is further enhanced by studies being conducted by similar agencies in other states or by federal resource protection agencies.
The core philosophy guiding the Conservation Department's management and research efforts is biodiversity. Missouri is unique among states in that it represents a merging of ecosystems from the north, south, east and west. We want to maintain our natural wealth by keeping Missouri habitable and desirable for all native species.
Editor - Tom Cwynar
Managing Editor - Bryan Hendricks
Art Editor - Dickson Stauffer
Artist - Dave Besenger
Artist - Mark Raithel
Photographer - Jim Rathert
Photographer - Cliff White
Staff Writer - Jim Low
Staff Writer - Joan McKee
Composition - Libby Bode Block
Circulation - Bertha Bainer


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plugin development in perl
I want to develop a plugin program,that plugs all my modules and configure this module and functions in the module using a configuration file with the help of a user interface.Plugin window will show functions which are configured through the config file and enable and disable these functions using a checkbox.
is there any CPAN module which helps the development of plugins?
Re: plugin development in perl
The POE::Component::Server::IRC::Plugin module is available in CPAN.
using this module we can add/delete our plugin.
Refer the link.
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The Vancouver Canucks held a news conference Wednesday afternoon on the firing of head coach Alain Vigneault and his assistants.
Switzerland upset Russia while the United States got...
Canada's four-day selection camp has begun in Regina...
Vancouver Canucks 4, Nashville Predators 2
The Canadiens are in Ottawa to play the Senators
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SAN ANGELO - Hartie Webb Moore, 101, died Monday, July 14, 2003.
Memorial Services will be announced at a later date. Arrangements are by Johnson's Funeral Home.
Mrs. Moore was born June 10, 1902, in Evansville, Tenn., to H.D. Webb and Mattie Mize. She married Achilbald Eugene Moore in February 1925. She was a homemaker most of her life, and also worked for Hendrick Medical Center in Abilene and Baptist St. Anthony's Hospital in Amarillo.
Hartie loved to work in her garden and was known as "Mom" to all of her friends. The family wishes to express a heartfelt thanks to Dr. Stephen Smith, Dr. Preston Darby, Vista Care Hospice, Regency House, and Frank and Marty at Community Pharmacy.
She was preceded in death by her husband; a son-in-law, H.E. McCoy; and a grandson, Frank Kantro.
Survivors include two daughters, Dorothy Kantro and husband, M.L., of San Angelo and Barbara Faye McCoy of Abilene; a son, Arnold Moore of San Angelo; two sisters, Gladys Allison and Reba Green, both of Amarillo; eight grandchildren; seven great-grandchildren; five great-great-grandchildren; and numerous nieces and nephews.
The family suggests memorials be to Meals For The Elderly or a favorite charity.
Amarillo Globe-News, July 17, 2003
© 2016. All Rights Reserved. | Contact Us


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BEIJING (AP) - A Japanese envoy has arrived in Beijing for talks aimed at cooling tensions over an island dispute that has raised fears of an armed confrontation.
Chinese media reported Tuesday that Mr Natsuo Yamaguchi was to deliver a letter from Japanese Prime Minister Shinzo Abe during his four-day visit. In Tokyo, he told reporters he hoped his trip would help ease tensions and that consultations were needed to "normalise our relationship."
Mr Yamaguchi heads the New Komeito party, the junior partner in the coalition led by Mr Abe's ruling Liberal Democratic Party.
Tensions soared after Japan's government bought the uninhabited islands, known in Chinese as Diaoyu and Japanese as Senkaku, from their private owners in September.
Both sides scrambled jet fighters this month in the latest spike in tensions.


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If you'd like to add a legend to your project, perhaps showing each kind of door or window that you've used, no need to draw this manually. With the Legend view, Revit allows you to place a graphical representation of any family that you have used in your project. You will be able to control the scale and the detail level, as well as whether or not you insert the symbol in the plan, elevation or section. Nice thing to know about the Legend view is that these graphics are representational only; they do not throw off the count of your schedules or otherwise get treated like actual parts of your model. So let's go ahead and take a look here. I am going to do a simple door legend. I am in a file called Legends in the Chapter 11 folder.
I am going to go to the View tab, and under Legends, I will choose a legend. It will ask me for a name. I am going to call this Door Types and Scale, and quarter-inch is the default, and that looks pretty good to me. So I'll click OK. The Legend view is actually kind of drafting view, so it's basically just a blank sheet of paper. The difference is that we can actually add legend components on it. So to do this we go over here to the Annotate tab and under the Component tool, and I want to just kind of point this out here as the first time look at this tool.
Look carefully at this icon. You can see it's really kind of two- dimensional and compare that to the Component tool on the Home tab, which was three-dimensional. So the components you have available on the Annotate tab are two-dimensional view specific components, and there is actually a few different varieties. Detail Components, Repeating Details. We'll look at some of those in the Detail movies upcoming. And Legend Component, which is what we're going to look at right now. So when you choose Legend Component, and on the Options bar you'll get lots of choices. So if we open up this list, for example, if you wanted to make a wall types legend, all of the wall families and types that you're using in your project will be listed here.
So you can go through, and we used Brick on MetalStud, or we used the 4 7/8" Partition. We could add one of each of those, and then use those as a wall types legend, or this was a doorlegend we are creating. So let's scroll up to the Door category, and see what we have available. So this project is using a couple of different doors. We've got a Double Glass Door. Now it's coming in plan here by default. We can actually change that.
So I am going to do a front elevation, which looks little nicer. So we will go ahead and bring in the elevation, then I will go to the next door, Single Flush Door. See how they line up nicely for us? And then a Single Glass Door. And that may be all of the ones we have used. Oh, we've got our Curtain Wall Door here. Now, the curtain wall door is a little bizarre because it comes in really, really tiny, but it turns out here that there is this Host Length.
The curtain wall doors are a little different than regular doors because they actually rely on the size of the curtain wall bay that you give them. So all we need to do is put in a more reasonable size bay. So how about 6 feet? Then we'll get a better size for our curtain wall door there. So we want to go ahead and click Modify, and next I can finish this out with text. So I could just basically click on a piece of text, type in a door name, and repeat the process over here.
Then we can do dimensions even, if you need to. If you don't wanted to actually say the dimension, you can click on it. Click right on the text, say Replace With Text, you can say See Plan, and add any other annotations and notes that you like, and that completes your legend. Then basically we can add this legend to our sheet. So if I come down and look for my Schedule Sheet, you can see there is already a door schedule and some other schedules on this sheet.
It seems like a good place to add my door legend. I am going to go ahead and expand Legends here, and just drag it right out of the Project Browser, and drop it wherever I want it to go on the view. So I will just kind of put it right over here. That's all there is to it. So you can create legends for any type of family that you have in your project, doors, walls, windows, whatever you need, and drag them on the sheet, and print them right along with the set.
- Introducing building information modeling (BIM)
- Adding levels, grids, and columns to set up a project
- Creating building layouts with walls, doors and windows
- Modifying wall types and properties
- Working with DWG files and CAD inserts
- Adding rooms
- Adding filled and masking regions and detailing
- Generate schedules and reports
- Understanding families
- Using reference planes, parameters and constraints
- Outputting files, including DWF and PDF files


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Gregory O. "Greg" Taylor, a partner with the Lubbock firm of D. Williams & Co., was recognized in August with the Silver Bowl award by the National Society of Accountants for Cooperatives during its annual meeting in Charleston, S.C.
The NSAC is a 1,500-member service organization of financial, legal, and management professionals, who work with or for cooperative businesses. The Silver Bowl award is NSAC's highest award for service to the organization and to cooperatives.
Taylor, a Ralls native, has been a partner with D. Williams & Co. since 1994 and has been with the firm since 1989.
He also has worked at KPMG in Lubbock and Doshier, Pickens & Francis in Amarillo.
A member of NSAC since 1993, Taylor has held numerous leadership roles with that organization, including national president for 2008-09.
Taylor graduated with a bachelor of business administration degree in accounting and finance from West Texas A&M University in 1983. In 1988, while working for Doshier, Pickens and Francis, he completed the requirements for a master's of business administration degree from WT.
"The faculty at WT provided us with a superb education in accounting and finance," Taylor said. "I had the great good fortune to learn from Jerry Miller, James Owens and the late Leon Trekell, and many others. WT is just a great place for hands-on quality instruction."
Source: National Society of Accountants for Cooperatives.


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Judy Neikirk - Social Services, Lead Instructor
Mrs. Judy Neikirk has been an instructor at Wabash Valley College since 2002. She holds an Associate in Applied Science in Marketing Mid/Management from Wabash Valley College, a Bachelor of Arts degree from Eastern Illinois University and a Master of Science degree in Community Counseling from Eastern Illinois University. She is a sponsor of the Social Services club.
Contact Information: 618-263-5108 or firstname.lastname@example.com


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Why hasn't BRKB moved up on recent rally...
Sentiment: Buy
People were nervous because of tapering , syria & the fact that Berkshire has gone from around 90-119.30 in a year. People took a little off. The fact that Hurricane season hasn't been bad so far, and Syria is now on the back burner .Berkshire is less than 5 % from it's alltime high too which hardley qualifies as being stalled .
My guess is it is a combination of valuation and supply & demand. The smart guys who are honest with themselves probably believe that BRK is trading at a fair, or even high, P/BV ratio. Every time a dumb bunny shows up and offers to buy a share at a slightly higher price the smart guys jump at the opporunity to sell that poor sucker their shares. Very simply, the supply of shares that the smart guys would love to unload (sell) exceeds the demand created by the naive, unsophisticated buyers. JMO.


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Redirect Check. Outil SEO LiveOptim : Optimisez vos contenus et votre temps. Modifier le fichier hosts sous Mac OSX 10.7 Lion. WebPagetest - Website Performance and Optimization Test. Open Site Explorer. Integrity - website link checker for Mac OSX. Easily find your website's broken links.
Scans your site checking for broken links - very fast, accurate and with Productivity featuresCheck images as well as all internal and external linksSupport for 'soft 404s'See problems at-a-glance highlighted in colour. Double-click for more detailed informationIn short, improve your website's quality and search engine rankingNew - Retina screen compatible and OSX Mavericks tested and supported If you've maintained a website for any length of time, you'll know that links very quickly become broken, because we move, delete or change our own pages, and other people that we link to do the same. A broken link on your site is a dead end for your visitors and will also be bad news for your search engine optimisation (SEO). Integrity is a link checker, no more, no less, no frills - and free (donationware). All of this is available in Scrutiny Requires Mac OSX 10.5 or higher, Intel 64-bit or 32-bit processor. Installation PC Version?
Screaming Frog SEO Spider Tool & Crawler Software. About The Tool The Screaming Frog SEO Spider allows you to quickly crawl, analyse and audit a site from an onsite SEO perspective.
It's particularly good for analysing medium to large sites, where manually checking every page would be extremely labour intensive (or impossible!) And where you can easily miss a redirect, meta refresh or duplicate page issue. You can view, analyse and filter the crawl data as it's gathered and updated continuously in the program's user interface. The SEO Spider allows you to export key onsite SEO elements (URL, page title, meta description, headings etc) to Excel so it can easily be used as a base for SEO recommendations. Crawl 500 URLs For Free The 'lite' version of the tool is free to download and use. For just £99 per year you can purchase a licence, which removes the 500 URL crawl limit, allows you to save crawls, opens up the spider's configuration options and custom source code search, extraction and Google Analytics integration features.
Updates. SpyOnWeb.com Research Tool — You Can Disclose Websites With The Same Google Adsense Code, Google Analytics Code, Ip Address etc. Web Hosting Search Tool. 30 SEO Resolutions for 2012. A Collection of 47 Helpful Google Search Operator Queries. To be honest, from my school days of using Google right up to today, the search engine giant has not once stopped impressing me.
From its algorithmic updates for a better user experience to its cloud based computing services, Google has captured my life and sadly, probably my soul. Today I will be sharing with you a collection of my favourite Google search operator queries, not only to help open your mind to the powers of Google being much more than a search engine, but also to show you that knowing some of these queries will help you become better in the art of SEO. 6 Starter Operator Search Operator Queries These queries are particularly helpful because they're generally quick and easy short cuts in narrowing your search results: 5 Basic Mathematics Search Operator Queries Google search provides users with the ability to calculate simple maths without the need for your calculator:
Web Site Migration Guide - Tips For SEOs. Site migrations occur now and again for a various reasons but arguably are one of those areas many SEOs and site owners alike do not feel very comfortable with.
Typically, site owners want to know in advance what the impact would be, often asking for information like potential traffic loss, or even revenue loss. On the other hand, SEOs need to make sure they follow best practice and avoid common pitfalls in order to make sure traffic loss will be kept to a minimum. Disclaimer: The suggested site migration process isn't exhaustive and certainly there are several alternative or complimentary activities, depending on the size of the web site as well as the nature of the undertaken migration. I hope that despite its length, the post will be useful to SEOs and web masters alike. Phase 1: Establishing Objectives, Effort & Process This is where the whole migration plan will be established taking into account the main objectives, time constrains, effort, and available resources.


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Defence volunteers shot dead in Pattani
Two defence volunteers were shot dead by suspected insurgents in Pattani's Sai Buri district yesterday morning, police said.
Sai Buri superintendent Pol Colonel Asis Umayee said Krissana Thepsao, 36, and Wirat InthongEiad, 42, were returning home in a pickup truck after having completed their shift at 10am, when four or five suspected insurgents, also in a pickup truck, fired at them with M16 assault rifles and a handgun. The two men died instantly from gunshot wounds to their head and torso, and the attackers made off with their pistols and three birds in a cage.
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Most Cited Pharmacological Research Articles
The most cited articles published since 2011, extracted from Scopus.
ERK1/2 MAP kinases: Structure, function, and regulationRobert Roskoski
Volume 66, Issue 2, August 2012, Pages 105-143
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. MEK1/2 catalyze the phosphorylation of human ERK1/2 at Tyr204/187 and then Thr202/185. The phosphorylation of both tyrosine and threonine is required for enzyme activation. Whereas the Raf kinase and MEK families have narrow substrate specificity, ERK1/2 catalyze the phosphorylation of hundreds of cytoplasmic and nuclear substrates including regulatory molecules and transcription factors. ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many ERK1/2 substrates possess a D-docking site, an F-docking site, or both. A variety of scaffold proteins including KSR1/2, IQGAP1, MP1, β-Arrestin1/2 participate in the regulation of the ERK1/2 MAP kinase cascade. The regulatory dephosphorylation of ERK1/2 is mediated by protein-tyrosine specific phosphatases, protein-serine/threonine phosphatases, and dual specificity phosphatases. The combination of kinases and phosphatases make the overall process reversible. The ERK1/2 catalyzed phosphorylation of nuclear transcription factors including those of Ets, Elk, and c-Fos represents an important function and requires the translocation of ERK1/2 into the nucleus by active and passive processes involving the nuclear pore. These transcription factors participate in the immediate early gene response. The activity of the Ras-Raf-MEK-ERK cascade is increased in about one-third of all human cancers, and inhibition of components of this cascade by targeted inhibitors represents an important anti-tumor strategy. Thus far, however, only inhibition of mutant B-Raf (Val600Glu) has been found to be therapeutically efficacious. © 2012 Elsevier Ltd. All rights reserved.
The ErbB/HER family of protein-tyrosine kinases and cancerRobert Roskoski
Volume 79, Issue , January 2014, Pages 34-74
The human epidermal growth factor receptor (EGFR) family consists of four members that belong to the ErbB lineage of proteins (ErbB1-4). These receptors consist of a glycosylated extracellular domain, a single hydrophobic transmembrane segment, and an intracellular portion with a juxtamembrane segment, a protein kinase domain, and a carboxyterminal tail. Seven ligands bind to EGFR including epidermal growth factor and transforming growth factor α, none bind to ErbB2, two bind to ErbB3, and seven ligands bind to ErbB4. The ErbB proteins function as homo and heterodimers. The heterodimer consisting of ErbB2, which lacks a ligand, and ErbB3, which is kinase impaired, is surprisingly the most robust signaling complex of the ErbB family. Growth factor binding to EGFR induces a large conformational change in the extracellular domain, which leads to the exposure of a dimerization arm in domain II of the extracellular segment. Two ligand-EGFR complexes unite to form a back-to-back dimer in which the ligands are on opposite sides of the aggregate. Following ligand binding, EGFR intracellular kinase domains form an asymmetric homodimer that resembles the heterodimer formed by cyclin and cyclin-dependent kinase. The carboxyterminal lobe of the activator kinase of the dimer interacts with the amino-terminal lobe of the receiver kinase thereby leading to its allosteric stimulation. Downstream ErbB signaling modules include the phosphatidylinositol 3-kinase/Akt (PKB) pathway, the Ras/Raf/MEK/ERK1/2 pathway, and the phospholipase C (PLCγ) pathway. Several malignancies are associated with the mutation or increased expression of members of the ErbB family including lung, breast, stomach, colorectal, head and neck, and pancreatic carcinomas and glioblastoma (a brain tumor). Gefitinib, erlotinib, and afatinib are orally effective protein-kinase targeted quinazoline derivatives that are used in the treatment of ERBB1-mutant lung cancer. Lapatinib is an orally effective quinazoline derivative used in the treatment of ErbB2-overexpressing breast cancer. Trastuzumab, pertuzumab, and ado-trastuzumab emtansine, which are given intravenously, are monoclonal antibodies that target the extracellular domain and are used for the treatment of ErbB2-positive breast cancer; ado-trastuzumab emtansine is an antibody-drug conjugate that delivers a cytotoxic drug to cells overexpressing ErbB2. Cetuximab and panitumumab are monoclonal antibodies that target ErbB1 and are used in the treatment of colorectal cancer. Cancers treated with these targeted drugs eventually become resistant to them. The role of combinations of targeted drugs or targeted drugs with cytotoxic therapies is being explored in an effort to prevent or delay drug resistance in the treatment of these malignancies.© 2013 Elsevier Ltd. All rights reserved.
The influence of diet on the gut microbiotaKaren P. Scott | Silvia W. Gratz | Paul O. Sheridan | Harry J. Flint | Sylvia H. Duncan
Volume 69, Issue 1, March 2013, Pages 52-60
Diet is a major factor driving the composition and metabolism of the colonic microbiota. The amount, type and balance of the main dietary macronutrients (carbohydrates, proteins and fats) have a great impact on the large intestinal microbiota. The human colon contains a dense population of bacterial cells that outnumber host cells 10-fold. Bacteroidetes, Firmicutes and Actinobacteria are the three major phyla that inhabit the human large intestine and these bacteria possess a fascinating array of enzymes that can degrade complex dietary substrates. Certain colonic bacteria are able to metabolise a remarkable variety of substrates whilst other species carry out more specialised activities, including primary degradation of plant cell walls. Microbial metabolism of dietary carbohydrates results mainly in the formation of short chain fatty acids and gases. The major bacterial fermentation products are acetate, propionate and butyrate; and the production of these tends to lower the colonic pH. These weak acids influence the microbial composition and directly affect host health, with butyrate the preferred energy source for the colonocytes. Certain bacterial species in the colon survive by cross-feeding, using either the breakdown products of complex carbohydrate degradation or fermentation products such as lactic acid for growth. Microbial protein metabolism results in additional fermentation products, some of which are potentially harmful to host health. The current 'omic era promises rapid progress towards understanding how diet can be used to modulate the composition and metabolism of the gut microbiota, allowing researchers to provide informed advice, that should improve long-term health status. © 2012 Elsevier Ltd. All Rights Reserved.
The oral microbiome in health and diseaseWilliam G. Wade
Volume 69, Issue 1, March 2013, Pages 137-143
The human mouth harbours one of the most diverse microbiomes in the human body, including viruses, fungi, protozoa, archaea and bacteria. The bacteria are responsible for the two commonest bacterial diseases of man: dental caries (tooth decay) and the periodontal (gum) diseases. Archaea are restricted to a small number of species of methanogens while around 1000 bacterial species have been found, with representatives from the phyla Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, Spirochaetes, Synergistetes and Tenericutes and the uncultured divisions GN02, SR1 and TM7. Around half of oral bacteria are as yet uncultured and culture-independent methods have been successfully used to comprehensively describe the oral bacterial community. The human oral microbiome database (HOMD, www.homd.org) provides a comprehensive resource consisting of descriptions of oral bacterial taxa, a 16S rRNA identification tool and a repository of oral bacterial genome sequences. Individuals' oral microbiomes are highly specific at the species level, although overall the human oral microbiome shows few geographical differences. Although caries and periodontitis are clearly bacterial diseases, they are not infectious diseases in the classical sense because they result from a complex interaction between the commensal microbiota, host susceptibility and environmental factors such as diet and smoking. Periodontitis, in particular, appears to result from an inappropriate inflammatory reaction to the normal microbiota, exacerbated by the presence of some disease-associated bacterial species. In functional terms, there appears to considerable redundancy among the oral microbiota and a focus on functional rather than phylogenetic diversity may be required in order to fully understand host-microbiome interactions. © 2012 Elsevier Ltd. All Rights Reserved.
The human milk microbiota: Origin and potential roles in health and diseaseLeónides Fernández | Susana Langa | Virginia Martín | Antonio Maldonado | Esther Jiménez | Rocío Martín | Juan M. Rodríguez
Volume 69, Issue 1, March 2013, Pages 1-10
Human milk has been traditionally considered sterile; however, recent studies have shown that it represents a continuous supply of commensal, mutualistic and/or potentially probiotic bacteria to the infant gut. Culture-dependent and -independent techniques have revealed the dominance of staphylococci, streptococci, lactic acid bacteria and bifidobacteria in this biological fluid, and their role on the colonization of the infant gut. These bacteria could protect the infant against infections and contribute to the maturation of the immune system, among other functions. Different studies suggest that some bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut monocytes. Thus, modulation of maternal gut microbiota during pregnancy and lactation could have a direct effect on infant health. On the other hand, mammary dysbiosis may lead to mastitis, a condition that represents the first medical cause for undesired weaning. Selected strains isolated from breast milk can be good candidates for use as probiotics. In this review, their potential uses for the treatment of mastitis and to inhibit mother-to-infant transfer of HIV are discussed. © 2012 Elsevier Ltd. All Rights Reserved.
The chemistry and biotransformation of tea constituentsShengmin Sang | Joshua D. Lambert | Chi Tang Ho | Chung S. Yang
Volume 64, Issue 2, August 2011, Pages 87-99
Tea (Camellia sinensis, Theaceae) is one of the most widely consumed beverages in the world. The three major types of tea, green tea, oolong tea, and black tea, differ in terms of the manufacture and chemical composition. There are numerous studies in humans, animal models, and cell lines to suggest potential health benefits from the consumption of tea, including prevention of cancer and heart diseases. Many of the health benefits have been attributed to the polyphenolic constituents in tea. Catechins and their dimers (theaflavins) and polymers (thearubigins) have been identified as the major components in tea. Methylation, glucuronidation, sulfation, and ring-fission metabolism represent the major metabolic pathways for tea catechins. The present review summarizes the data concerning the chemistry and biotransformation of tea constituents. © 2011 Elsevier Ltd.
Cancer prevention by tea: Evidence from laboratory studiesChung S. Yang | Hong Wang | Guang Xun Li | Zhihong Yang | Fei Guan | Huanyu Jin
Volume 64, Issue 2, August 2011, Pages 113-122
The cancer preventive activities of tea (Camellia sinensis Theaceae) have been studied extensively. Inhibition of tumorigenesis by green tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancers of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, prostate, and mammary glands. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea. These molecular events can result in cellular changes, such as enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis. Nevertheless, the molecular mechanisms of inhibition of carcinogenesis in animals and humans remain to be further investigated. Future research directions in this area are discussed. © 2011 Elsevier Ltd.
Dietary phytochemicals and their potential effects on obesity: A reviewMarta González-Castejón | Arantxa Rodriguez-Casado
Volume 64, Issue 5, November 2011, Pages 438-455
The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. Indeed, obesity facilitates the development of metabolic disorders such as diabetes, hypertension, and cardiovascular diseases in addition to chronic diseases such as stroke, osteoarthritis, sleep apnea, some cancers, and inflammation-bases pathologies. In this review we summarize the progresses made in our understanding of obesity, including the role of inflammation process, the recently understood endocrine function of adipose tissue, as well as passive roles of processes of energy storage and adipogenesis related to fat cell lifecycle: differentiation, maturation, and apoptosis. In addition, the article discusses the anti-obesity potential of dietary phytochemicals and analyzes their mechanisms of action, e.g. induction of apoptosis and lipolysis and inhibition of inflammation. © 2011 Elsevier Ltd.
P62/SQSTM1/A170: Physiology and pathologyMasaaki Komatsu | Shun Kageyama | Yoshinobu Ichimura
Volume 66, Issue 6, December 2012, Pages 457-462
p62/SQSTM1/A170 (hereafter referred to as p62) is a stress-inducible intracellular protein known to regulate various signal transduction pathways involved in cell survival and cell death. Comprehensive analysis of LC3 (an autophagosome localizing protein)-binding proteins resulted in the recognition of autophagy and p62. While autophagy modulates the level of p62 protein, p62 can suppress autophagy via activation of mTORC1. Moreover, growing lines of evidence point to the important role of p62 in directing ubiquitinated cargos toward autophagy as well as compaction of those cargos. Furthermore, this protein functions as a signaling hub for various signal transduction pathways, such as NF-κB signaling, apoptosis, and Nrf2 activation, whose dysregulation is associated with Paget disease of bone and tumorigenesis. In this review, we discuss the pathophysiological significance of p62 and its role in autophagy. © 2012 Elsevier Ltd.
One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery diseaseJoão Tomé-Carneiro | Mar Larrosa | María J. Yáñez-Gascón | Alberto Dávalos | Judit Gil-Zamorano | Manuel Gonzálvez | Francisco J. García-Almagro | José A. Ruiz Ros | Francisco A. Tomás-Barberán | Juan Carlos Espín | María Teresa García-Conesa
Volume 72, Issue , June 2013, Pages 69-82
Numerous studies have shown that resveratrol (RES) exerts anti-inflammatory effects but human trials evidencing these effects in vivo are limited. Furthermore, the molecular mechanisms triggered in humans following the oral intake of RES are not yet understood. Therefore, the purpose of this study was to investigate the molecular changes in peripheral blood mononuclear cells (PBMCs) associated to the one-year daily intake of a RES enriched (8 mg) grape extract (GE-RES) in hypertensive male patients with type 2 diabetes mellitus (T2DM). We used microarrays and RT-PCR to analyze expression changes in genes and microRNAs (miRs) involved in the inflammatory response modulated by the consumption of GE-RES in comparison to a placebo and GE lacking RES. We also examined the changes in several serobiochemical variables, inflammatory and fibrinolytic markers. Our results showed that supplementation with GE or GE-RES did not affect body weight, blood pressure, glucose, HbA1c or lipids, beyond the values regulated by gold standard medication in these patients. We did not find either any significant change on serum inflammatory markers except for a significant reduction of ALP and IL-6 levels. The expression of the pro-inflammatory cytokines CCL3, IL-1β and TNF-α was significantly reduced and that of the transcriptional repressor LRRFIP-1 increased in PBMCs from patients taking the GE-RES extract. Also, a group of miRs involved in the regulation of the inflammatory response: miR-21, miR-181b, miR-663, miR-30c2, miR-155 and miR-34a were found to be highly correlated and altered in the group consuming the GE-RES for 12 months. Our results provide preliminary evidence that long-term supplementation with a grape extract containing RES downregulates the expression of key pro-inflammatory cytokines with the involvement of inflammation-related miRs in circulating immune cells of T2DM hypertensive medicated patients and support a beneficial immunomodulatory effect in these patients. © 2013 Elsevier Ltd. All rights reserved.
Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in ratsNatale R. Sciolino | Wenyi Zhou | Andrea G. Hohmann
Volume 64, Issue 3, September 2011, Pages 226-234
Dysregulation in signaling of the endocannabinoid 2-arachidonoylglycerol (2-AG) is implicated in hyperresponsiveness to stress. We hypothesized that blockade of monoacylglycerol lipase (MGL), the primary enzyme responsible for 2-AG deactivation in vivo, would produce context-dependent anxiolytic effects in rats. Environmental aversiveness was manipulated by varying illumination of an elevated plus maze. Percentage open arm time and numbers of open and closed arm entries were measured in rats receiving a single intraperitoneal (i.p.) injection of either vehicle, the MGL inhibitor JZL184 (1-8 mg/kg), the benzodiazepine diazepam (1 mg/kg), the cannabinoid CB1 receptor antagonist rimonabant (1 mg/kg), or JZL184 (8 mg/kg) coadministered with rimonabant (1 mg/kg). JZL184 (8 mg/kg) produced anxiolytic-like effects (i.e., increased percentage open arm time and number of open arm entries) under high, but not low, levels of environmental aversiveness. Diazepam produced anxiolytic effects in either context. Rimonabant blocked the anxiolytic-like effects of JZL184, consistent with mediation by CB1. Anxiolytic effects of JZL184 were preserved following chronic (8 mg/kg per day × 6 days) administration. Chronic and acute JZL184 treatment similarly enhanced behavioral sensitivity to an exogenous cannabinoid (WIN55,212-2; 2.5 mg/kg i.p.) 24 or 72 h following the terminal injection, suggesting a pervasive effect of MGL inhibition on the endocannabinoid system. We attribute our results to alterations in emotion rather than locomotor activity as JZL184 did not alter the number of closed arm entries in the plus maze or produce motor ataxia in the bar test. Our results demonstrate that JZL184 has beneficial, context-dependent effects on anxiety in rats, presumably via inhibition of MGL-mediated hydrolysis of 2-AG. These data warrant further testing of MGL inhibitors to elucidate the functional role of 2-AG in controlling anxiety and stress responsiveness. Our data further implicate a role for 2-AG in the regulation of emotion and validate MGL as a therapeutic target. © 2011 Elsevier Ltd. All rights reserved.
Tea and cancer prevention: Epidemiological studiesJian Min Yuan | Canlan Sun | Lesley M. Butler
Volume 64, Issue 2, August 2011, Pages 123-135
Experimental studies have consistently shown the inhibitory activities of tea extracts on tumorigenesis in multiple model systems. Epidemiological studies, however, have produced inconclusive results in humans. A comprehensive review was conducted to assess the current knowledge on tea consumption and risk of cancers in humans. In general, consumption of black tea was not associated with lower risk of cancer. High intake of green tea was consistently associated with reduced risk of upper gastrointestinal tract cancers after sufficient control for confounders. Limited data support a protective effect of green tea on lung and hepatocellular carcinogenesis. Although observational studies do not support a beneficial role of tea intake on prostate cancer risk, phase II clinical trials have demonstrated an inhibitory effect of green tea extract against the progression of prostate pre-malignant lesions. Green tea may exert beneficial effects against mammary carcinogenesis in premenopausal women and recurrence of breast cancer. There is no sufficient evidence that supports a protective role of tea intake on the development of cancers of the colorectum, pancreas, urinary tract, glioma, lymphoma, and leukemia. Future prospective observational studies with biomarkers of exposure and phase III clinical trials are required to provide definitive evidence for the hypothesized beneficial effect of tea consumption on cancer formation in humans. © 2011 Elsevier Ltd.
Probiotics and health: An evidence-based reviewPaolo Aureli | Lucio Capurso | Anna Maria Castellazzi | Mario Clerici | Marcello Giovannini | Lorenzo Morelli | Andrea Poli | Fabrizio Pregliasco | Filippo Salvini | Gian Vincenzo Zuccotti
Volume 63, Issue 5, May 2011, Pages 366-376
The intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m2. The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings. This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine. © 2011 Elsevier Ltd.
Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosisMireia Urpi-Sarda | Rosa Casas | Gemma Chiva-Blanch | Edwin Saúl Romero-Mamani | Palmira Valderas-Martínez | Sara Arranz | Cristina Andres-Lacueva | Rafael Llorach | Alex Medina-Remón | Rosa M. Lamuela-Raventos | Ramon Estruch
Volume 65, Issue 6, June 2012, Pages 577-583
Previous epidemiological and feeding studies have observed that adherence to Mediterranean diet (Med-Diet) is associated with reduced cardiovascular risk. However, the molecular mechanisms involved are not fully understood. Since atherosclerosis is nowadays considered a low-grade inflammatory disease, recent studies have explored the anti-inflammatory effects of a Med-Diet intervention on serum and cellular biomarkers related to atherosclerosis. In two sub-studies of the PREDIMED (PREvencion con DIeta MEDiterranea) trial, we analyzed the effects at 3 months of two Med-Diet interventions supplemented with either virgin olive oil (VOO) or nuts compared with a control low-fat diet (LFD). Both Med-Diets showed an anti-inflammatory effect reducing serum C-reactive protein, interleukin-6 (IL6) and endothelial and monocytary adhesion molecules and chemokines (P < 0.05; all), whereas these parameters increased after the LFD intervention (P < 0.05; all). In another substudy, we evaluated the long-term (1 year) effects of these interventions on vascular risk factors in 516 high-risk subjects, as well as the effect of different Med-Diet components in the reduction of these biomarkers. At 1 year, the Med-Diet groups had significant decreases in the plasma concentrations of IL6, tumor necrosis factor receptor (TNFR) 60 and TNFR80 (P < 0.05), while intercellular adhesion molecule 1 (ICAM-1), TNFR60 and TNFR80 concentrations increased in the LFD group (P < 0.002). In addition, those allocated in the highest tertile of VOO and vegetables consumption had a significant diminution of plasma TNFR60 concentration compared with those in tertile 1 (P < 0.02). In conclusion, Med-Diet exerts an anti-inflammatory effect on cardiovascular system since it down-regulates cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high cardiovascular risk. © 2012 Elsevier Ltd. All rights reserved.
Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomesWim Vanden Berghe
Volume 65, Issue 6, June 2012, Pages 565-576
Cancer, as one of the non-communicable diseases, remains one of the leading causes of death around the world. Recently, epigenetic changes in DNA methylation patterns at CpG sites (epimutations) or deregulated chromatin states of tumor promoting genes and noncoding RNAs emerged as major governing factors in tumor progression and cancer drug sensitivity. Furthermore, various environmental factors such as nutrition, behavior, stress, and toxins remodel our epigenomes lifelong in a beneficial or detrimental way. Since epigenetic marks (epimutations) are reversible in contrast to genetic defects, chemopreventive nutritional polyphenols (soy, genistein, resveratrol, catechin, curcumin) are currently evaluated for their ability to reverse adverse epigenetic marks in cancer (stem) cells to attenuate tumorigenesis-progression, prevent metastasis or sensitize for drug sensitivity. Although polyphenols in fruit and vegetables may help to reduce the risk of cancer, few protective effects have been firmly established, presumably because of inappropriate timing or dosing of diet exposure or due to confounding factors such as smoking and alcohol. In this review will discuss the possible epigenetic contributions of dietary polyphenols in cancer chemoprevention. © 2012 Elsevier Ltd. All rights reserved.
Weight control and prevention of metabolic syndrome by green teaSudathip Sae-Tan | Kimberly A. Grove | Joshua D. Lambert
Volume 64, Issue 2, August 2011, Pages 146-154
Green tea (Camellia sinensis, Theaceace) is the second most popular beverage in the world and has been extensively studied for its putative disease preventive effects. Green tea is characterized by the presence of a high concentrations of polyphenolic compounds known as catechins, with (-)-epigallocatechin-3-gallate (EGCG) being the most abundant and most well-studied. Metabolic syndrome (MetS) is a complex condition that is defined by the presence of elevated waist circumference, dysglycemia, elevated blood pressure, decrease serum high-density lipoprotein-associated cholesterol, and increased serum triglycerides. Studies in both in vitro and laboratory animal models have examined the preventive effects of green tea and EGCG against the symptoms of MetS. Overall, the results of these studies have been promising and demonstrate that green tea and EGCG have preventive effects in both genetic and dietary models of obesity, insulin resistance, hypertension, and hypercholesterolemia. Various mechanisms have been proposed based on these studies and include: modulation of dietary fat absorption and metabolism, increased glucose utilization, decreased de novo lipogenesis, enhanced vascular responsiveness, and antioxidative effects. In the present review, we discuss the current state of the science with regard to laboratory studies on green tea and MetS. We attempt to critically evaluate the available data and point out areas for future research. Although there is a considerable amount of data available, questions remain in terms of the primary mechanism(s) of action, the dose-response relationships involved, and the best way to translate the results to human intervention studies. © 2011 Elsevier Ltd.
Methylglyoxal promotes oxidative stress and endothelial dysfunctionCristina M. Sena | Paulo Matafome | Joana Crisóstomo | Lisa Rodrigues | Rosa Fernandes | Paulo Pereira | Raquel M. Seiça
Volume 65, Issue 5, May 2012, Pages 497-506
Modern diets can cause modern diseases. Research has linked a metabolite of sugar, methylglyoxal (MG), to the development of diabetic complications, but the exact mechanism has not been fully elucidated. The present study was designed to investigate whether MG could directly influence endothelial function, oxidative stress and inflammation in Wistar and Goto-Kakizaki (GK) rats, an animal model of type 2 diabetes. Wistar and GK rats treated with MG in the drinking water for 3 months were compared with the respective control rats. The effects of MG were investigated on NO-dependent vasorelaxation in isolated rat aortic arteries from the different groups. Insulin resistance, NO bioavailability, glycation, a pro-inflammatory biomarker monocyte chemoattractant protein-1 (MCP-1) and vascular oxidative stress were also evaluated. Methylglyoxal treated Wistar rats significantly reduced the efficacy of NO-dependent vasorelaxation (p < 0.001). This impairment was accompanied by a three fold increase in the oxidative stress marker nitrotyrosine. Advanced glycation endproducts (AGEs) formation was significantly increased as well as MCP-1 and the expression of the receptor for AGEs (RAGE). NO bioavailability was significantly attenuated and accompanied by an increase in superoxide anion immunofluorescence. Methylglyoxal treated GK rats significantly aggravated endothelial dysfunction, oxidative stress, AGEs accumulation and diminished NO bioavailability when compared with control GK rats. These results indicate that methylglyoxal induced endothelial dysfunction in normal Wistar rats and aggravated the endothelial dysfunction present in GK rats. The mechanism is at least in part by increasing oxidative stress and/or AGEs formation with a concomitant increment of inflammation and a decrement in NO bioavailability. The present study provides further evidence for methylglyoxal as one of the causative factors in the pathogenesis of atherosclerosis and development of macrovascular diabetic complication. © 2012 Elsevier Ltd. All rights reserved.
Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of actionMichael O. Griffin | Guillermo Ceballos | Francisco J. Villarreal
Volume 63, Issue 2, February 2011, Pages 102-107
Tetracyclines were developed as a result of the screening of soil samples for antibiotics. The first t of these compounds, chlortetracycline, was introduced in 1947. Tetracyclines were found to be highly effective against various pathogens including rickettsiae, as well as both gram-positive and gram-negative bacteria, thus becoming the first class of broad-spectrum antibiotics. Many other interesting properties, unrelated to their antibiotic activity, have been identified for tetracyclines which have led to widely divergent experimental and clinical uses. For example, tetracyclines are also an effective anti-malarial drug. Minocycline, which can readily cross cell membranes, is known to be a potent anti-apoptotic agent. Another tetracycline, doxycycline is known to exert anti-protease activities. Doxycycline can inhibit matrix metalloproteinases which contribute to tissue destruction activities in diseases such as periodontitis. A large body of literature has provided additional evidence for the "beneficial" actions of tetracyclines, including their ability to act as reactive oxygen species scavengers and anti-inflammatory agents. This review provides a summary of tetracycline's multiple mechanisms of action as a means to understand their beneficial effects. © 2010 Elsevier Ltd.
Tea and cardiovascular diseaseApranta Deka | Joseph A. Vita
Volume 64, Issue 2, August 2011, Pages 136-145
There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect. We also review observational and intervention studies that investigated an effect of tea and tea extracts on cardiovascular risk factors, including blood pressure, serum lipids, diabetes mellitus, and obesity. Finally, we review potential mechanisms of benefit, including anti-inflammatory, anti-oxidant, and anti-proliferative effects, as well as favorable effects on endothelial function. Overall, the observational data suggest a benefit, but results are mixed and likely confounded by lifestyle and background dietary factors. The weight of evidence indicates favorable effects on risk factors and a number of plausible mechanisms have been elucidated in experimental and translational human studies. Despite the growing body evidence, it remains uncertain whether tea consumption should be recommended to the general population or to patients as a strategy to reduce cardiovascular risk. © 2011 Elsevier Ltd.
New perspectives in melatonin usesA. Carpentieri | G. Díaz De Barboza | V. Areco | M. Peralta López | N. Tolosa De Talamoni
Volume 65, Issue 4, April 2012, Pages 437-444
This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potential uses of melatonin in the sleep-wake rhythms, in the immune function, in cancer therapy, in neuroprotection against oxidative damage and antioxidant activities in different tissues. Finally, combined effects of melatonin with other drugs are discussed. © 2012 Elsevier Ltd. All rights reserved.
Beneficial effects of polyphenols on cardiovascular diseaseMar Quiñones | Marta Miguel | Amaya Aleixandre
Volume 68, Issue 1, February 2013, Pages 125-131
In recent years, numerous studies have demonstrated the health benefits of polyphenols, and special attention has been paid to their beneficial effects against cardiovascular disease, the leading cause of death in the world today. Polyphenols present vasodilator effects and are able to improve lipid profiles and attenuate the oxidation of low density lipoproteins. In addition, they present clear anti-inflammatory effects and can modulate apoptotic processes in the vascular endothelium. It has been suggested that most of these effects are a consequence of the antioxidant properties of polyphenols, but this idea is not completely accepted, and many other mechanisms have been proposed recently to explain the health effects of these compounds. In fact, different signaling pathways have been linked to polyphenols. This review brings together some recent studies which establish the beneficial properties of polyphenols for cardiovascular disease and analyzes the mechanisms involved in these properties. © 2012 Elsevier Ltd.
The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertensionDongmin Shao | John E S Park | Stephen J. Wort
Volume 63, Issue 6, June 2011, Pages 504-511
The term pulmonary arterial hypertension (PAH) describes a rare group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles (<100 mm). Left untreated, patients die from right heart failure, with a mortality approaching most serious cancers. Endothelin-1(ET-1) is not only a potent vasoconstrictor, but causes proliferation of many of the vascular cells involved in vascular remodelling. Although produced mainly by the vascular endothelium, other cells such as smooth muscle, fibroblasts and macrophages are known sources of ET-1 when these cells are challenged by relevant stimuli. Plasma ET-1 levels are raised in patients with PAH and correlate with important clinical outcomes. Furthermore, ET-1 receptor antagonism has been demonstrated to improve both morbidity and mortality in conditions associated with PAH. We review the literature supporting the role for ET-1 in the pathogenesis of PAH. © 2011 Elsevier Ltd. All rights reserved.
Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axisTakanori Matsui | Yuri Nishino | Masayoshi Takeuchi | Sho Ichi Yamagishi
Volume 63, Issue 5, May 2011, Pages 383-388
Vildagliptin is a stable inhibitor of dipeptidyl peptidase-IV, a responsible enzyme that mainly inactivates glucagon-like peptide-1, and now one of the widely used agents for the treatment of diabetes. However, effects of vildagliptin on vascular injury in diabetes are largely unknown. Since advanced glycation end products (AGEs) and their receptor RAGE axis are reported to contribute to vascular complications in diabetes, we investigated here whether vildagliptin inhibits vascular damage in thoracic aorta of Otsuka Long-Evans Tokushima Fatty rats (OLETF rats), an animal model of type 2 diabetes with obesity, by blocking the AGEs-RAGE axis. OLETF and control LETO rats at 22 weeks old were given vehicle or 3 mg/kg of vildagliptin for another 12 weeks. Vildagliptin treatment decreased fasting plasma glucose and heart rate in OLETF rats. Compared with control LETO rats, levels of AGEs, RAGE mRNA and protein, an oxidative stress marker, 8-hydroxydeoxyguanosine, two membrane components of NADPH oxidase, p22 and gp91phox mRNAs, and phospho-NF-κB p65 in thoracic aorta were significantly enhanced in OLETF rats, all of which were inhibited by the treatment with vildagliptin. Vildagliptin significantly reduced both mRNA and protein levels of monocyte chemoattractant protein-1, vascular cell adhesion molecule-1 and plasminogen activator inhibitor-1 in thoracic aorta of OLETF rats. Enhanced expression of transforming growth factor-β in the aorta of diabetic rats was also suppressed by vildagliptin. Our present data suggest that vildagliptin could play a protective role against vascular injury in diabetes partly by attenuating the deleterious effects of AGEs-RAGE-oxidative stress axis. © 2011 Elsevier Ltd.
Colorectal cancer chemoprevention by trans-resveratrolM. Emília Juan | Irene Alfaras | Joana M. Planas
Volume 65, Issue 6, June 2012, Pages 584-591
trans-Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin present in grapes, red wine, berries and peanuts with health protecting properties. The low oral bioavailability indicated for this polyphenol, with the intestine as a bottleneck to its absorption, has promoted the large intestine as a potential target site for its chemopreventive activity. This review recapitulates the current evidence of the effects of trans-resveratrol on colon cancer. First, we describe the studies conducted in vitro which show that the protective activity takes place by inhibition of proliferation and induction of apoptosis. Secondly, the chemopreventive activity in animal models of colon carcinogenesis is revised. trans-Resveratrol not only reduces the number of preneoplastic lesions but also the incidence and multiplicity of tumors. Lastly, the article also reviews the available data on clinical trials. Altogether, the present findings support the hypothesis that the oral administration of trans-resveratrol might contribute to the prevention of colon carcinogenesis. © 2012 Elsevier Ltd. All rights reserved.
Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibitionRobert Roskoski
Volume 68, Issue 1, February 2013, Pages 68-94
Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas. ALK is a receptor protein-tyrosine kinase that was more fully characterized in 1997. Physiological ALK participates in embryonic nervous system development, but its expression decreases after birth. ALK is a member of the insulin receptor superfamily and is most closely related to leukocyte tyrosine kinase (Ltk), which is a receptor protein-tyrosine kinase. Twenty different ALK-fusion proteins have been described that result from various chromosomal rearrangements, and they have been implicated in the pathogenesis of several diseases including anaplastic large-cell lymphoma, diffuse large B-cell lymphoma, and inflammatory myofibroblastic tumors. The EML4-ALK fusion protein and four other ALK-fusion proteins play a fundamental role in the development in about 5% of non-small cell lung cancers. The formation of dimers by the amino-terminal portion of the ALK fusion proteins results in the activation of the ALK protein kinase domain that plays a key role in the tumorigenic process. Downstream signaling from ALK fusion proteins involves the Ras/Raf/MEK/ERK1/2 cell proliferation module and the JAK/STAT cell survival pathway. Furthermore, nearly two dozen ALK activating mutations participate in the pathogenesis of childhood neuroblastomas along with ALK overexpression. The occurrence of oncogenic ALK, particularly in non-small cell lung cancer, has generated considerable interest and effort in developing ALK inhibitors. Currently, crizotinib has been approved by the US Food and Drug Administration for the treatment of ALK-positive non-small cell lung cancer along with an approved fluorescence in situ hybridization kit used for the diagnosis of the disease. The emergence of crizotinib drug resistance with a median occurrence at approximately 10 months after the initiation of therapy has stimulated the development of second-generation drugs for the treatment of non-small cell lung cancer and other disorders. About 28% of the cases of crizotinib resistance are related to nearly a dozen different mutations of ALK in the EML4-ALK fusion protein; the other cases of resistance are related to the upregulation of alternative signaling pathways or to undefined mechanisms. It is remarkable that the EML4-ALK fusion protein was discovered in 2007 and crizotinib was approved for the treatment of ALK-positive non-small cell lung cancer in 2011, which is a remarkably short timeframe in the overall scheme of drug discovery. © 2012 Elsevier Ltd.


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Festivals and Events in Honolulu
Author Kevin Whitton covers the best festivals and events during the calendar year, from the Lantern Floating Hawaii festival on Memorial Day to the Hawaii Food & Wine Festival in September and more.
Author Kevin Whitton covers the best festivals and events during the calendar year, from the Lantern Floating Hawaii festival on Memorial Day to the Hawaii Food & Wine Festival in September and more.
The galleries and boutiques of Old Makawao are less touristy than Lahaina's Front Street shops. Author Kyle Ellison shares a helpful guide to shopping for art, jewelry, clothing, and gifts.
Guaitíl pottery is synonymous with Costa Rica's indigenous crafts. In visiting this tranquil little village, you can take pottery classes and learn more about local culture and the ancient symbolism of the designs.
Queechee is a region beset by contrasts. The natural beauty of the Ottauquechee River completes with tourist shops that seem beholden to a retro era of car-touring and motor lodges.
Belize is a melting pot of cultures, religions, languages, and ethnicities. In this article, author Victoria Day-Wilson discusses the general culture of Belize, including everything from the types of popular cuisine to the likelihood of finding a golf course or a race track.
Want to know what to see in Scottsdale? Many of the city's historic and cultural attractions center on Old Town, while North Scottsdale is home to two must-see attractions: the fabulous Musical Instrument Museum and Frank Lloyd Wright's winter home, Taliesin West. Kathleen Bryant gives an overview of the best sights in Scottsdale.
Sedona's cultural calendar encompasses everything from intimate studio tours to grand galas. Most large outdoor events are scheduled for fall, when the weather is at its finest. Kathleen Bryant suggests some of the top events to enjoy.
Hollyanna McCollom points you toward the best art in Portland, from museum galleries to unique home decor to imported artifacts. Also featured are free events like Art in the Pearl and a self-guided tour offered by the Regional Arts and Culture Council.
About 70 kilometers southwest of the capital via Ruta 68, the dusty village of Pomaire produces many of the clay pots used in homes and restaurants to bake traditional Chilean foods.
People love to shop in Old San Juan because it offers the widest variety of unique shopping options in one pedestrian-friendly place. This is the place to go for fine jewelry, imported clothing and furnishings, cigars, folk art, tourist trinkets, and American chain stores, such as Marshalls, Walgreens, and Radio Shack.


text: Home > LifeStyle > Fashion & Beauty Hottest Women Over 40 By MensXPFebruary 21, 2013 facebook twitter reddit gplus SKIP AD Image 1 of 7 Related Galleries Next Gallery Starts in 12 Secs X SKIP WAITING AUTOPLAY ON OFF Prev Next 9 Hollywood Celebs That Are Bringing the Pixie Cut Back in Vogue These Action Heroines Make All The Bad Guys Want To Run And Hide! Feast Your Eyes On 30 Of Hollywood's Hottest Actresses Under 30! 10 Celebrities Who Cheated On Their Men Candid Photos: Barack Obama Visits Stonehenge USA Celebrates its Independence Day: PICS 66910 Prev Next The fountain of youth may seem like a phrase straight out of fairytales, but it surely does exist. For some gorgeous ladies are like fine wine - they get better with age. Here are a few divas on the planet who set the benchmark when it comes to fighting the aging phenomena. Presenting before you the list of irresistible, ravishing beauties... Michelle Obama: America's First Lady exemplifies grace and beauty like most can't. Among the crop of the hottest women over 40, Mrs. Obama is one of those few non-actresses who can give the young lasses a serious run for their money. You pick all the clichés like 'beauty with brains', or 'aging like a wine' and put all of them together to describe her; rest assured they would fit her astutely well. For the record, she is well past the 40-mark. She just turned 49 on January 17th. Gwyneth Paltrow: If there is one thing that manages to take our attention away from the metal-equipped, whizzing superhero Iron Man, then that's the ever-so-ravishing Gwyneth Paltrow. The former Oscar winning actress has the charm and the resonant beauty that never seems to age even a day, lest you forget she turned 40. Small wonder her husband Chris Martin can't stop singing her praises! Salma Hayek: She is completely incompetent and incapable...of not looking hot. The mesmeric beauty of a woman at 46, Hayek looks hot on red carpets, she looks hotter on beaches and she can blow your mind even while holding a gun (Remember her portrayal in Frida?). The true epitome of sexiness, she's driven and tough, but coy enough to melt any man's heart. Halle Berry: We don't care if she visits her plastic surgeon once in a while. What we care and see is that she never seems to age—at least not from the past 10 years. She is known to exercise religiously, which leaves us baffled as to how she manages so many roles in her kitty. At 46, the true Bond girl has a daughter named Nahla that makes her one of the hottest moms around. Courteney Cox: Has Courteney Cox always taken care of herself? Damn right. She wouldn't be on our hottest list otherwise. She has indeed gone under the knife quite a few times but that does not make her any less bewitching at 48. While her style is getting better with each passing day, Courteney remains the hottest 'friend' every man would love to have. Jennifer Aniston: The friends' star has just turned 44 and doesn't look a day over 34. We feel as if we're looking at the real-life Benjamin Button because she seems to be aging in reverse, looking much better than she did five years ago. We saw how these women are giving their younger counterparts a run for their money with their sizzling persona. The age-numbers are climbing, but not catching up with these captivatingly beautiful ladies. We definitely like it! < 1 2 3 4 5 > Follow @indiatimes facebook twitter reddit gplus Comment Here The fountain of youth may seem like a phrase straight out of fairytales, but it surely does exist. For some gorgeous ladies are like fine wine - they get better with age. Here are a few divas on the planet who set the benchmark when it comes to fighting the aging phenomena. Presenting before you the list of irresistible, ravishing beauties... ADVERTISEMENT


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ATLANTA - For four days, the Phillies dispersed. Most went home. A few vacationed at the beach, and one traveled to Minnesota. They convened Friday at Turner Field, a group of 25 men still intact from last weekend. That will not last.
Ryne Sandberg relaxed in Cape May, and the Phillies manager heard unsolicited advice from fans. He, like everyone in the Phillies clubhouse, knows change is looming. He watched another dispiriting loss, 6-4, to first-place Atlanta, and he must create another lineup Saturday because that is what this job demands.
Sandberg portrayed a scenario in which the final two months are spent researching alternatives. (The manager is not yet ready to concede.) Grady Sizemore will play five times a week. Darin Ruf and Freddy Galvis, both recovering from injuries this weekend at triple-A Lehigh Valley, could see regular action. None of those names will generate jubilation.


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Safe And Sound
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I could show you what you want to see
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MILL VALLEY, Calif. -- Mollie Stone's Markets has introduced a selection of produce items certified by a third party to be free of pesticide residues. On its Web site, the upscale Bay Area independent touted the program, dubbed "Clean Greens" throughout the chain's seven stores, as an addition to its conventional and organic produce offerings. The company noted the pesticide-free designation indicates the fruits and vegetables have met a standard that is "up to a thousand times tougher than ...
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