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From the Departments of Epidemiology and Biostatistics (Drs Engelhart, Geerlings, Ruitenberg, Stijnen, Hofman, Witteman, and Breteler) and Neurology (Drs Ruitenberg and van Swieten), Erasmus Medical Center, Rotterdam, the Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht (Dr Geerlings), Numico Research, Wageningen (Dr Kiliaan and Mr Meijer), and the Department of Anatomy, University Medical Center, Nijmegen (Dr Kiliaan), the Netherlands.
Increased levels of inflammatory proteins have been found in the brains and plasma samples of patients with dementia. Whether the levels of inflammatory proteins in plasma samples are elevated before clinical onset of dementia is unclear.
To determine whether high levels of inflammatory proteins in plasma samples are associated with an increased risk of dementia.
Design and Setting
A case-cohort study within the Rotterdam Study, a population-based prospective cohort study in the Netherlands.
The source population comprises 6713 subjects who, at baseline (1990-1993), were free of dementia and underwent venipuncture. From these, we selected both a random subcohort of 727 subjects and 188 cases who had developed dementia at follow-up.
Main Outcome Measures
The associations between plasma levels of α1-antichymotrypsin, C-reactive protein, interleukin 6, the soluble forms of intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 and the risk of dementia were examined using the Cox proportional hazards regression models.
High levels of α1-antichymotrypsin, interleukin 6, and, to a lesser extent, C-reactive protein were associated with an increased risk of dementia; rate ratios per standard deviation increase were 1.49 (95% confidence interval, 1.23-1.81), 1.28 (95% confidence interval, 1.06-1.55), and 1.12 (95% confidence interval, 0.99-1.25), respectively. Similar associations were observed for Alzheimer disease, whereas rate ratios of vascular dementia were higher for α1-antichymotrypsin and C-reactive protein. Soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were not associated with dementia.
Plasma levels of inflammatory proteins are increased before clinical onset of dementia, Alzheimer disease, and vascular dementia.
Neuritic plaques and neurofibrillary tangles are the classic neuropathological features in the brains of patients with Alzheimer disease (AD). Furthermore, inflammation has been demonstrated in AD-affected brains as is indicated by the presence of activated microglia and inflammatory proteins.1 In addition to inflammation within the brain, the peripheral immune system of patients with dementia may be activated as well. This is suggested by cross-sectional studies that reported elevated blood levels of the inflammatory proteins α1-antichymotrypsin (ACT),2- 4 C-reactive protein (CRP),5 (IL) 66 in patients with AD compared with control subjects. Prospectively, increased CRP levels have been associated with an increased risk of dementia 25 years later.7 Whether the levels of ACT and IL-6 are increased before the onset of dementia is yet unknown, although the recent finding of an association between the level of IL-6 and cognitive decline suggests elevated IL-6 levels before dementia.8,9 To our knowledge, no studies examined the association between the levels of ACT and IL-6 and dementia in a population-based setting, nor has the association been studied between the levels of other inflammatory proteins, such as cell adhesion molecules (CAMs), and dementia. We investigated the relation between plasma ACT, CRP, IL-6, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and the risk of dementia in a large population-based prospective study.
The Rotterdam Study is a population-based prospective cohort study among persons aged 55 years and older, who were living in Ommoord, a suburb of the city of Rotterdam, the Netherlands.10 The study was approved by the medical ethics committee of the Erasmus Medical Center, Rotterdam. The objective was to investigate determinants of chronic and disabling diseases.10
The overall response rate was 78% corresponding to 7983 participants, from whom written informed consent was obtained. At the baseline examination (1990-1993) blood samples were drawn from 7050 subjects (88% of the total cohort). Of these, cognitive status was assessed in 7047 subjects. Dementia was diagnosed in 334 participants resulting in a source population of 6713 subjects who both were dementia free and had venipuncture at baseline. Follow-up examinations occurred in the time spans of 1993-1994 and 1997-1999.
The study population comprises a subcohort of 727 subjects who were randomly drawn in July 1998 from the source population. At that time, we additionally selected all 146 cases of incident dementia that had occurred outside the subcohort. We followed up the subcohort until December 31, 1999. By then, 42 subjects of the subcohort had developed dementia. Thus, cases of the present study were composed of 188 cases of incident dementia, in which 140 subjects were diagnosed as having AD, 23 subjects as having vascular dementia, and 25 subjects as having other dementias.
During baseline and follow-up examinations the diagnosis of dementia followed a similar 3-step protocol.11 Two brief tests of cognition (Mini-Mental State Examination12 and Geriatric Mental State Schedule organic level13) were used to screen all subjects. Participants with positive screening scores of less than 26 on the Mini-Mental State Examination or an organic level of more than 0 on the Geriatric Mental State Schedule underwent further cognitive testing using the Cambridge examination (CAMDEX) for mental disorders of elderly persons.14 Subjects who were thought to have dementia were examined by a neurologist (J.C.vS.) and a neuropsychologist; if possible, the brains of these subjects also underwent magnetic resonance imaging. In addition, the total cohort was continuously monitored for incident dementia through computerized linkage between the study database and digitalized medical records from general practitioners and the Regional Institute for Outpatient Mental Health Care, Rotterdam.11 Dementia diagnoses were made in accord with internationally accepted criteria for dementia (DSM-III-R),15 AD (National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association [NINCDS-ADRDA]),16 and vascular dementia (National Institute of Neurological Disorders and Stroke–Association Internationale pour la Recherche et l'Enseignement en Neurosciences [NINDS-AIREN]).17
The levels of inflammatory proteins from the study population were assessed in baseline plasma samples that had been stored at −80°C. The ACT and CRP levels were measured by kinetic nephelometry (Nephelometer BN200; Dade-Behring, Marburg, Germany). The CRP measurement is highly sensitive and the World Health Organization CRP Reference Standard was used. The levels of IL-6, sICAM-1, and sVCAM-1 were determined by means of commercially available enzyme-linked immunosorbent assays (Quantikine HS IL-6 kit; R & D Systems Europe, Oxon, England; sICAM-1 and sVCAM-1 kits; R & D Systems Europe). Interassay coefficients of variations for ACT, CRP, IL-6, sICAM-1, and sVCAM-1 were 2.8%, 4.4%, 8.7%, 6.9%, and 5.0%, respectively.
At baseline we obtained information on the subject's educational level, tobacco smoking, and use of anti-inflammatory medication (nonsteroidal anti-inflammatory drugs [NSAIDs] or corticosteroids) or statins. In addition, we determined body mass index (calculated as weight in kilograms divided by the square of height in meters), systolic blood pressure, and the presence of diabetes mellitus. An ultrasonogram of both carotid arteries was performed.
As indicators of atherosclerosis, we used the following 3 measures: peripheral arterial disease defined as an ankle-brachial ratio of the systolic blood pressure below or above 0.9, intima media thickness of the carotid arteries,18 and atherosclerotic carotid plaques determined at 6 different locations18 according to which 4 categories were created: 0, 1 to 2, 3 to 4, and 5 to 6.
The association between plasma levels of ACT, CRP, IL-6, sICAM-1, and sVCAM-1, respectively, and incident dementia and its subtypes was evaluated in a case-cohort design by use of standard Cox proportional hazards regression models with modification of standard errors based on robust variance estimates.19
The levels of inflammatory proteins were first entered into the model as quintiles to explore any deviations from linearity in the relation with dementia. In case of a nonlinear association or a threshold-effect, all analyses were performed using quintiles. Otherwise, the levels of inflammatory proteins were entered into the model through a linear term, in which the regression coefficient was expressed per standard deviation increase. All analyses were adjusted for age, gender, and educational level, and additionally for tobacco smoking, body mass index, diabetes mellitus, use of anti-inflammatory medication, and atherosclerosis. The analyses were repeated after exclusion of subjects taking anti-inflammatory medication (n = 93, 10.7%), subjects with possible acute inflammation as is indicated by CRP levels higher than 15 mg/L (n = 53, 6.1%), and users of statins (n = 18, 2.1%), respectively. Analyses were performed using SAS statistical software (version 6.12; SAS Institute Inc, Cary, NC).
Table 1 gives the baseline characteristics of the subcohort. The mean (SD) age was 71.7 (9.0) years, a slight majority were women, and one third had only a primary education.
In Figure 1 the median level of inflammatory proteins within quintiles was plotted against rate ratios of dementia on a logarithm scale. The rate ratio of the highest quintile compared with the lowest quintile was 2.92 (95% confidence interval [CI], 1.34-6.36) for ACT, 1.37 (95% CI, 0.67-2.77) for CRP, 1.42 (95% CI, 0.62-3.23) for IL-6, 1.20 (95% CI, 0.47-3.08) for sICAM-1, and 0.55 (95% CI, 0.27-1.13) for sVCAM-1. From the Figure 1, we saw no reason to assume that the associations could not be described by a linear term given the wide and overlapping 95% CIs of the point estimates within quintiles.
Rate ratio (RR) of dementia across quintiles of inflammatory proteins in plasma α1-antichymotrypsin (ACT) (A), C-reactive protein (CRP) (B), interleukin 6 (IL-6) (C), soluble intercellular adhesion molecule-1 (sICAM-1) (D), and soluble vascular cell adhesion molecule-1 (sVCAM-1) (E). Adjustments were made for age, gender, and educational level. Median levels of inflammatory protein within quintiles are plotted on the x-axis; RRs of dementia are plotted on a logarithm-transformed y-axis.
Table 2 lists the rate ratios of dementia and its subtypes per standard deviation increase in the level of inflammatory protein, adjusted for age, gender, and educational level. Higher levels of ACT, IL-6, and, to a lesser extent, CRP were associated with an increased risk of dementia. Rate ratios were 1.49 (95% CI, 1.23-1.81) for ACT, 1.12 (95% CI, 0.99-1.25) for CRP, and 1.28 (95% CI, 1.06-1.55) for IL-6. The levels of ACT, CRP, and IL-6 were also associated with an increased risk of AD, although the levels of ACT and CRP were most strongly associated with vascular dementia. The levels of sICAM-1 and sVCAM-1 were not associated with dementia and its subtypes.
Data in Table 3 demonstrate that the relation between the levels of inflammatory proteins and dementia did not change substantially after additional adjustments for tobacco smoking, body mass index, diabetes mellitus, use of anti-inflammatory medication, or atherosclerosis.When the analyses were performed after exclusion of the data for users of anti-inflammatory medication, subjects with CRP levels higher than 15 mg/L, or users of statins, the results also remained similar.
We observed that elevated plasma levels of ACT and IL-6 were associated with an increased risk of dementia, AD, and vascular dementia. This association was less clear for CRP and was nonexistent for sICAM-1 and sVCAM-1.
Strengths of the present study are its population-based design, size, complete dementia follow-up, and the adjustments for an extensive number of confounders. A limitation of the study is the lack of repeated measurements of the levels of inflammatory proteins, which may have resulted in dilution of the associations owing to within-person variability and measurement error. In addition, we lack data on white matter lesions and small infarcts in the brain. As a consequence, we do not know whether white matter lesions and small infarcts may explain the observed association between the level of inflammatory proteins and dementia.
Our findings agree with cross-sectional studies showing that blood levels of ACT and IL-6 are higher in patients with dementia compared with controls.2- 4,6 In addition, our observations on CRP are in accord with the recent finding of elevated CRP levels 25 years before the clinical onset of dementia, AD, and vascular dementia.7 To our knowledge, blood levels of CAMs in relation to dementia have not been studied before, but neuropathological findings showed no expression of these adhesion molecules on the endothelial cells of capillaries in AD-affected brains.20
Elevated plasma levels of ACT and CRP before the diagnosis of dementia likely originate from an increased production in the peripheral immune system, because the levels of ACT and CRP in brains are generally more than 100 times lower than in plasma.3 In contrast, increased levels of IL-6 may be derived from increased production either in the brain or in the periphery, because IL-6 levels are similar in brain and plasma.6
Increased levels of inflammatory proteins in plasma before the clinical onset of dementia may suggest that peripheral inflammation is involved in the pathogenetic process leading to dementia. This is supported by several observations. First, anti-inflammatory medication use, such as NSAID use, is associated with a decreased risk of dementia.21,22 Although NSAIDs can have affects within the brain, the effect of NSAIDs on dementia risk may also act by suppressing the peripheral immune system. Second, ACT is known to reinforce the formation of β-amyloid deposits,23,24 which is thought to be crucial in the pathogenesis of AD. Because peripheral proteins are able to cross the blood-brain barrier25 and because the permeability of the blood-brain barrier may increase with rising plasma levels of inflammatory proteins such as IL-6,26 peripherally produced inflammatory proteins might also amplify formation of cerebral β-amyloid deposits. Third, atherosclerosis, which is an inflammatory process,27 may be associated with increased risk of dementia.10 The idea of atherosclerosis being a link between peripheral inflammation and dementia is supported by our observation of relatively strong associations of ACT and CRP with vascular dementia. However, adjustment for atherosclerosis did not change our results and the risk associated with IL-6 was similar for AD and vascular dementia. Also, because atherosclerosis may be associated with increased plasma levels of sICAM-1,18 one would also have expected an association between sICAM-1, sVCAM-1, and the risk of dementia if atherosclerosis was to contribute to the pathogenesis of dementia. On the other hand, elevated levels of inflammatory proteins in plasma may be a consequence of the pathophysiological process of dementia. Peripheral inflammation may result from cerebral β-amyloid deposition that induces local production of inflammatory proteins, such as IL-1 and IL-6.1 These cerebrally produced cytokines may increase peripheral levels of inflammatory proteins because they pass either through the blood-brain barrier25 or through stimulation of peripheral production of inflammatory proteins as shown in animal models.28 If the activation of the peripheral immune system is both a cause and a consequence of the pathogenetic process of dementia, a self-enhancing cascade will occur. This cascade includes β-amyloid deposit formation that leads to local inflammation within the brain resulting in the activation of the peripheral immune system that leads to increased β-amyloid deposit formation.
High plasma levels of ACT, IL-6, and, to a lesser extent, CRP were associated with an increased risk of dementia, AD, and vascular dementia. Whether peripheral inflammation contributes to the pathogenesis of dementia remains to be elucidated.
Corresponding author: Monique M. B. Breteler, MD, PhD, Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, the Netherlands (e-mail: firstname.lastname@example.com).
Accepted for publication December 29, 2003.
Author contributions: Study concept and design (Drs Engelhart, Geerlings, Kiliaan, Ruitenberg, Hofman, and Breteler); acquisition of data (Drs Engelhart, Kiliaan, Ruitenberg, van Swieten, and Breteler and Mr Meijer); analysis and interpretation of data (Drs Engelhart, Geerlings, Ruitenberg, van Swieten, Stijnen, Witteman, and Breteler); drafting of the manuscript (Drs Engelhart, Geerlings, Kiliaan, and Breteler and Mr Meijer); critical revision of the manuscript for important intellectual content (Drs Engelhart, Geerlings, Ruitenberg, van Swieten, Stijnen, Hofman, Witteman, and Breteler); statistical expertise (Drs Stijnen, Witteman, and Breteler); obtained funding (Drs Kiliaan, Hofman, and Breteler); administrative, technical, and material support (Dr Kiliaan and Mr Meijer); study supervision (Drs Geerlings, Ruitenberg, Hofman, and Breteler).
This study was supported by the Netherlands Organization for Scientific Research, The Hague, by an unrestricted grant from Numico Research BV, Wageningen, the Netherlands, and by grant IIRG-99-1534 from the Alzheimer's Association, Maastricht, the Netherlands (Dr Breteler).
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Digitization is driving a fundamental change in society that is transforming the way businesses work with their customers, their supply chains and their people. Digital transformation leverages DevOps best practices, such as Agile Parallel Development, Continuous Delivery and Agile Operations to capitalize on opportunities and create competitive differentiation in the application economy. However, information security has been notably absent from the DevOps movement. Speed doesn't have to negat...
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The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...
Sep. 28, 2016 07:00 AM EDT Reads: 3,368
There is little doubt that Big Data solutions will have an increasing role in the Enterprise IT mainstream over time. Big Data at Cloud Expo - to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA - has announced its Call for Papers is open. Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is...
Sep. 28, 2016 07:00 AM EDT Reads: 2,691
Your business relies on your applications and your employees to stay in business. Whether you develop apps or manage business critical apps that help fuel your business, what happens when users experience sluggish performance? You and all technical teams across the organization – application, network, operations, among others, as well as, those outside the organization, like ISPs and third-party providers – are called in to solve the problem.
Sep. 28, 2016 06:00 AM EDT Reads: 2,631
SYS-CON Events announced today the Kubernetes and Google Container Engine Workshop, being held November 3, 2016, in conjunction with @DevOpsSummit at 19th Cloud Expo at the Santa Clara Convention Center in Santa Clara, CA. This workshop led by Sebastian Scheele introduces participants to Kubernetes and Google Container Engine (GKE). Through a combination of instructor-led presentations, demonstrations, and hands-on labs, students learn the key concepts and practices for deploying and maintainin...
Sep. 28, 2016 05:00 AM EDT Reads: 2,731
SYS-CON Events announced today the Enterprise IoT Bootcamp, being held November 1-2, 2016, in conjunction with 19th Cloud Expo | @ThingsExpo at the Santa Clara Convention Center in Santa Clara, CA. Combined with real-world scenarios and use cases, the Enterprise IoT Bootcamp is not just based on presentations but with hands-on demos and detailed walkthroughs. We will introduce you to a variety of real world use cases prototyped using Arduino, Raspberry Pi, BeagleBone, Spark, and Intel Edison. Y...
Sep. 28, 2016 04:45 AM EDT Reads: 2,991
As applications are promoted from the development environment to the CI or the QA environment and then into the production environment, it is very common for the configuration settings to be changed as the code is promoted. For example, the settings for the database connection pools are typically lower in development environment than the QA/Load Testing environment. The primary reason for the existence of the configuration setting differences is to enhance application performance. However, occas...
Sep. 28, 2016 04:30 AM EDT Reads: 851


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As the aroma of funnel cakes and firecrackers wafted across the Benjamin Franklin Parkway on Friday night, Victoria Whartenby, 14, made a sacrifice for her favorite singer.
The petite girl from Clayton would never catch a glimpse of Ed Sheeran with taller fans towering over her. So she got a better view - from the back of a garbage truck.
"Anything for Ed," she said with a smile, unfazed by the smell, as she scanned over the crowd of concertgoers.
Hundreds of thousands of people throughout the day packed Philadelphia, from the green yard behind Independence Hall to the steps of the Art Museum, to celebrate the city's annual Fourth of July celebration, billed as America's biggest free concert and party, and capped by a spectacular display of fireworks.


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Poor broke, and I DO mean broke, homeless #$%$ John Osborne z50com and VW: we all see you are the truly owned here is YOU. You are the psycho that lives to stalk made up names from long ago posters while you run every intelligent poster off. One hopes your z50com and VW ebay sites suffer the way you will on your sick way to hades.
Your publicly witnessed obsession only hurts you and your failing z50com and VW ebay sites. Look how this board is mostly your posts. THAT is your own personal slavery. Every poster on every site you've wrecked and even your own family can't wait to #$%$ on your grave. Likely you rotting stinking cadaver will be homeless too. Glad to see you're melting so hard. Glad to see you're being all RIPPLES and publicly threatening.
Glad to see you wrecked ebay again today for me., Your insanity at least profits the shorts. The only reason I suffer you to live. I think your ongoing misery is funny. I know it's about to get much worse and has nowhere to go but down. Ian is observing your every move. You're oblivious. A deer in our headlights. You, Flything, and all your sullied IDs have only this as your life's legacy. Disgusting.
"we all see you are the truly owned here is YOU"
More "best author" writing skills? James would be proud ~ LOL
Poor broke insane John Osborne, ebay's z50com and VW: I never claimed to be "Best Author". The man who earned that title hasn't been on this board since 2005, so thanks for, once again, proving my point slave, and thanks for all the easy shorting money every time your meth kicks and you melt this board. You're jUST a joke now and harmless to everyone. Ian could jerk your chain instantly. It must be a very uncomfortable feeling having your every move monitored. We can see it's pushing you over your tiny little edge. When it's all said and done and you're laid to rest with Fly and all your IDs "word" to your molested neglected drug addicted daughter. Word.


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Drugs seem to have little effect on esophageal function. Many patients with hypertension and other disorders receive drugs affecting autonomic function, yet dysphagia and pyrosis are not commonly produced. There are at least two explanations. Esophageal motor dysfunction could occur but remain asymptomatic or trivially symptomatic. Second, the nerves that govern esophageal motor function could be of a kind not affected by such agents. Both explanations are probably true. It is now recognized that manometrically detectable esophageal motor dysfunction occurs (in diabetes and alcoholism, for example) without much symptomatic evidence. Also, at least some of the nerves that govern the operation of the esophagus appear neither to be adrenergic nor cholinergic.
The esophagus contains three physiologically-distinct regions, the striated muscle segment, the smoothmuscled esophageal body, and the lower esophageal sphincter. These three regions will be discussed separately.
Motor nerves to striated
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Jackson County Fair
Pascagoula, MS 39567
Held each mid-October, this fair includes an agricultural and industrial showcase, arts and crafts, exhibits, a midway, and delicous foods.
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at 12:13, 09-27-2016.
Pascagoula Area Attractions
Gulf Coast Gator Ranch and Airboat Rides
Beach Park & Pier
I'm Alone Charters
Naval Station Pascagoula
Scranton Museum
Scranton Nature Center
Old Depot Art & Gallery
La Pointe-Krebs House


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The Nolcha Shows are a leading award winning event, held during New York Fashion Week, for independent fashion designers to showcase their collections to a global audience of press, retailers, stylists and industry influencers. Over the past seven years the Nolcha Shows have become established as a platform of discovery; promoting cutting edge innovative fashion designers through runway shows and exhibitions.
The Nolcha Shows have built an acclaimed reputation as a hot incubator of new fashion design talent and are officially listed by New York City Economic Development Corporation; offering a range of cost effective options to increase independent fashion designers recognition and develop their business. The successful showcase consistently receives positive media coverage including features in Forbes, Wall Street Journal, Entrepreneur, New York Times, Glamour, Cosmopolitan, NBC and Inc and supported by brands including smartwater, Rusk, Vitamin Water, American Airlines, Don Q Rums and Landrover.
Invite Only
Bryant Park Hotel
The days are getting cooler, the nights are getting longer and we can hardly contain our excitement! September 22nd officially marked the first day of fall and although he sun […]
New York Fashion Week is behind us and we're looking ahead! This week our Monday Must Haves is all about the Nolcha Shows team favorite accessories from independent designers that are […]
The Nolcha Shows at New York Fashion Week just wrapped the Spring/Summer 2017 season at Artbeam Studios, featuring 13 runway shows. The day kicked off with the "Ones To […]
"The Nolcha Shows events give independent designers a share of the spotlight during a week dominated by Oscar de la Renta, Ralph Lauren, Marc Jacobs and other powerhouse brands."
- Entrepreneur Magazine
"Fortunately, there's help to be found beyond the Bryant Park tents. Programs such as the Nolcha Shows help new designers get started."
- Forbes
"While the fanfare is centered around Mercedes Benz Fashion Week, it's far from the only glamour game in town."
- New York Post
"Dedicated to bringing business to the forefront of the fashion industry."
I'm forever grateful for the amazing chance to be able to show my collection during New York Fashion Week to connect with press and other influential industry! Thank you to the Nolcha team for believing in me and introducing me to celebrities to dress for the shows as well as supporting my business needs as I launch in USA
- Yvette Hass
Working with Nolcha was a great experience. Launching my collection, there was so much to take care of and they truly made it easier. Their team was very professional and guided me through the whole process. If it wasn't for Nolcha, I would have not been able to launch my first collection. You guys are amazing!
- Danilo Gabrielli
The biggest satisfaction was to have launched in one of the most important fashion scenes of the world and it had not been possible without Nolcha's support. Congratulations to the Nolcha team and to the professionalism of the whole production.‐‐
- Mark Patito


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Spatial Foresight
Spatial Foresight GmbH is a Luxembourg-based company which provides territorial policy support and research. The fields of activity comprise:
- Analysis and evaluation
- Process facilitation
- Strategy development
- Training and dissemination
- Territorial foresight processes
- European and comparative studies
The principle idea is to bring together territorial development and policy processes with foresight oriented approaches. Foresight encompasses a range of approaches that combine strategic analysis, prospective forward thinking and process oriented dialogical work. Using these approaches for the processes shaping our territories will facilitate a better understanding of how to best capitalise on territorial development potentials.
The latest news about new projects, publications and forthcoming presentations by the Spatial Foresight team:
PROJECT INSIGHTS: Sustainable urban development and urban planning under the EUAID China R&I Partnership
Spatial Foresight staff Erik Gløersen and Sabine Zillmer have conducted a 2nd training session on sustainable urban development workshops in China between September 18 and 23. This was done in the frame of the MEDIUM project, funded by the EU-China Research and Innovation Partnership on sustainable urban development.
It included an excursion to the city of Zhuhai as well as a three days training workshop with about 20 post-graduate and PhD students from Sun Yat-sen University in Guangzhou. During this training the students were trained to develop and hold participative stakeholder workshops, through exercises focusing on the city of Zhuhai. Their newly acquired competence will allow them to organise workshops with stakeholders of urban development in this city over the coming months. This will be done in cooperation with Zhuhai's planning authority, and should help to prepare the revision of its Master Plan in 2017.
September 2016
NEW EVENT: Focus group on the added value of EU macro-regional strategies
ESIF and other programmes and funding sources contribute to the four EU macro-regional strategies, EU Strategy for the Baltic Sea Region, EU Strategy for the Danube Region, EU Strategy for the Adriatic and Ionian Region and EU Strategy for the Alpine Region. What is the benefit of this contribution for the programmes and funding sources, and the projects they fund?
Spatial Foresight together with INTERACT organise a focus group on 27 October in Brussels to discuss the benefits macro-regional strategies offer to programmes and projects. Participation is free of charge for registered participants. More information about the programme and details about your registration can be found at: http://www.spatialforesight.eu/added-value-study.html
Imagine Europe
Spatial Foresight has initiatited a discussion on possible futures for Europe. Given the increasing talks about stronger nation states and a weaker EU, we would like to stimulate some discussion about what Europe would look like if it were the other way around. Please feel free to submit your thoughts via our website: http://www.spatialforesight.eu/imagine-europe.html
August 2016
Call for internships
Spatial Foresight offers one or two paid internships to work on ongoing project concerning the future Europe. Find out more at http://www.spatialforesight.eu/interns-europe.html
August 2016
NEW PUBLICATION: Review of Adopted ETC Programmes
Spatial Foresight has contributed to a review of adopted European Territorial Cooperation Programmes (ETC). The European Parliament's REGI Committee has published the report of this study. The report offers insights on the strategic choices made by Member States and programme authorities for programme content and management, synergies with other EU, national and regional level instruments, implementing tools and simplification measures foreseen by the regulations. Spatial Foresight team member's have in particular contributed to the chapters on Synergies between ETC programmes and other planning instruments and ETC Programme management structures.
Levralet, F., Perku, A., Lorgeoux, E., Brignani, N., Wills, T.J.B., Zillmer, S., Holstein, F. & Stumm, T. (2016). Review of Adopted European Territorial Cooperation Programmes. European Parliament. Policy Department B: Structural and Cohesion Policies.
July 2016
NEW PROJECT: Monitoring indicators and targets in the European Union Strategy for the Baltic Sea Region
The European Union Strategy for the Baltic Sea Region (EUSBSR) is the first macro-regional strategy in Europe. It aims at reinforcing cooperation within the region to face several challenges by working together as well as promoting a more balanced development in the area. The assignment on monitoring indicators and targets in the EUSBSR shall take stock of the situation as regards the monitoring of the objectives and sub-objectives of the EUSBSR by making use relevant indicators, identify monitoring needs by key stakeholders, allowing it to feed the results into the establishment of a macro-regional monitoring system. The main element of this analysis is an interactive workshop with relevant players taking place in late June 2016.
July 2016
NEW PROJECT: Added value of macro-regional cooperation: Collecting practice examples
The added value of macro-regional cooperation has been debated for many years and in different contexts. All these debates have shown that there is need for more solid evidence on the actual added value. INTERACT has commissioned Spatial Foresight to conduct a study to collect evidence on the added value of the macro-regional strategies for the Baltic Sea Region and the Danube Region. The primary focus is on concrete projects and the added value both for the funding programmes involved and the macro-regions in general.
July 2016
NEW PROJECT: Interreg Central Europe Evaluation
Spatial Foresight has been awarded the operational evaluation of the Interreg CENTRAL EUROPE 2014 - 2020 Programme. Supported by t33, Spatial Foresight will evaluate the effectiveness and efficiency of programme management and implementation, appraise the appropriate functioning of the programme management settings, and carry out a first assessment of the Programme's mid-term progress towards the achievement of its objectives. An effective method mix will applied, consisting of desk research, in-depth interviews with programme stakeholders, a participatory action research and co-design approach to the evaluation of programme management settings and processes and a systemic approach to the assessment of the programme's governance structures.
July 2016
NEW PROJECT: Gold-plating in the European Structural and Investment Funds
In the implementation of European Structural and Investment Funds (ESI Funds) European as well as national and sub-national regulatory frameworks need to be applied. In some cases there are national, regional or local rules and regulations (or failures to apply simplification measures) which make European Union legislation unnecessarily complicated and hence costly when implemented in the Member States. This is understood as gold-plating. To better understand the nature of gold-plating the European Parliament has commissioned a study on gold-plating in ESI Funds and its impacts on the administrative work and burden for programme bodies and beneficiaries under all five ESI Funds (ERDF, CF, ESF, EAFRD, EMFF). The study will address a range of questions through the combination of different methodologies that includes a general overview on all 28 EU Member States and some in-depth studies for selected countries. The study will be led by Spatial Foresight and conducted in collaboration with ÖIR and t33.
July 2016
NEW PROJECT: Mapping Research and Innovation Plans&Strategies for Smart Specialisation on Bioeconomy
Spatial Foresight has been awarded a study for DG RESEARCH & INNOVATION regarding the "Mapping of EU Member States'/Regions' Research and Innovation Plans & Strategies for Smart Specialisation (RIS3) on Bioeconomy for 2014-2020". The study will generate evidence on the intended activities in EU Member States regarding their strategic bioeconomy focus. Successful regional research and innovation initiatives related to the bioeconomy and their transfer potentials shall be identified as well as corresponding bottlenecks and gaps. The study will be led by Spatial Foresight and conducted in collaboration with SWECO, Nordregio, INFYDE, Berman Group, t33 and ÖIR.
June 2016


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Thomas Weilacher
Cristina Reis,Stephen Talbot
Silvio Schwarz,Hannelore Schwarz
Thomas Weber
Not a member
The Joint ETSI-CEPT Workshop on Public Protection and Disaster Relief - Regulatory Changes and New Opportunities for Broadband PPDR- took place on 29 September 2016 in Sophia Antipolis at the ETSI headquarters, and was attended by about 100 participants.
Information about the Workshop on 29 September 2016 at ETSI, the programme, access to presentations and the closing remarks (first summary) are now available.
The next WG FM meeting will take place on 17-21 October 2016 in Bordeaux, France. The invitation is available on the meeting documents server. The online-registration for the meeting has been opened.
The 85th meeting of the WG FM took place in Helsinki, Finland, at the kind invitation from the Finnish CEPT Administration FICORA.
It was attended by 98 participants from 34 CEPT administrations and 18 international organisations, EC, ECO and ITU. The following results have been achieved:
The ECC held a CEPT Workshop on Machine-To-Machine Communications (M2M) on 21-22 March 2016 in Mainz, Germany (hosted by the Federal Network Agency). 134 participants from national regulatory authorities, industry representatives, experts and professionals attended the workshop to discuss spectrum as well as numbering and addressing harmonisation needs of existing and future M2M applications. In addition, a streaming service could be used by viewers to follow most of the workshop.
The 84th meeting of the WGFM took place in Cluj-Napoca, Romania, at the kind invitation from the Romanian CEPT Administration ANCOM.
It was attended by 101 participants from 29 CEPT administrations and 12 international organisations, EC, ECO and ITU. See here an overview of the results:


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Duva: Drug Testing Not Discussed Yet for Hopkins-Kovalev
by David P. Greisman
Advanced drug testing was not part of the conversation when contracts were signed last week for the upcoming light heavyweight unification fight between Sergey Kovalev and Bernard Hopkins.
And one of the promoters involved in the fight believes that it should be up to the athletic commissions to handle drug testing in a sport that to this point is woefully behind in what drug testing is being conducted.
"You know, it hasn't even been discussed," said Kathy Duva of Main Events, when asked about the matter immediately after Kovalev's win over Blake Caparello on Saturday night.
"I tend to personally believe that it's the commission's job to regulate," she said. "That's my own personal belief. But the subject hasn't even come up. … I don't know that either side is going to demand it. I think that commissions have to take the lead in that. I don't necessarily believe that it's up to boxing promoters to regulate. I think it's a bad, bad way to go."
She was then asked whether advanced drug testing should start somewhere, such as with the promoters, if the commissions aren't conducting it.
"Again my personal belief is that we are not qualified to do it, and I have seen where promoters have done it, and there are situations where people agree to do it and the tests don't even get done," Duva said. "It's ridiculous. I think that we've got two great fighters here, and I'm not going to assume they're cheating."
Pick up a copy of David's book, "Fighting Words: The Heart and Heartbreak of Boxing," at http://bit.ly/fightingwordsamazon or internationally at http://bit.ly/fightingwordsworldwide. Send questions/comments via email at [email protected]
Every one here seems to have an axe to grind with BHop. Anyone ever wonder why Duva and Kovalev aren't screaming for extra testing? Maybe they are both roiding...Comment by TheSurgeonMDMPH on 08-04-2014
The speculation has been around Bhopal for some time now. There is a reason Duva is screaming the Packtard anthem, "let the commission do their job". She has been around forever. She knows.Comment by Zen_Fighter on 08-04-2014
[QUOTE=Inkanyamba;14822769]Really? I know one thing's for sure, Bernard won't oppose drug tests for one of his biggest fights to date like Manny has. He's not scared of needles.[/QUOTE] Manny wasn't opposed to testing. He was opposed (for whatever reason) being…Comment by whoseyourdaddy on 08-04-2014
[QUOTE=Pan-Africanist;14822896]I thought this fight was a done deal? Here we go again with smear campaign. When did boxing become politics?[/QUOTE] when it comes down to testing Pacquiao you jump into it like a school girl, when it has to be…Comment by whoseyourdaddy on 08-04-2014
[QUOTE=Inkanyamba;14822769]Really? I know one thing's for sure, Bernard won't oppose drug tests for one of his biggest fights to date like Manny has. He's not scared of needles.[/QUOTE] Really! name me one fight Hopkins had take any blood test? he…Post a Comment - View More User Comments (35)


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Bills' defense showed off aggressive side [1:59 AM]
Buffalo News reports: '"When we really wanted to make a change and sell out more to a 3-4 defense, it was going to be based on a couple of things: having an outstanding nose tackle, and then having a great pass rusher," Ryan said. "Jerry's been great. It's interesting because as much havoc as he causes, he only got his first sack of the game on a three-man rush. It's tough sledding, but he found a way to get in there and did a great job."'
Bills release kicker Jordan Gay, make two practice-squad moves [1:58 AM]
Buffalo News reports: 'Vaughn, 6-3 and 306 pounds, signed with the Oakland Raiders as an undrafted free agent following this year's draft. He played in 46 games with 38 starts at Stephen F. Austin.'
Passing offense ranks last in NFL through three weeks [1:57 AM]
Buffalo News reports: '"We'd like to have more production, there's no doubt about it," coach Rex Ryan said. "I think it was going to be tough this last week. Obviously, we really didn't know that we wouldn't have Sammy Watkins. We didn't know we wouldn't have Greg Salas right up until game time. So that was pretty tough. But we'll see how it goes. Hopefully those guys will be in. We'll be able to get after it."'
Vic Carucci's Take Five: Bills' offense needs to stick with faster tempo [1:56 AM]
Buffalo News reports: 'That never allowed the Arizona Cardinals' defense to get fully set before each snap or find any sort of rhythm, especially when it came to stopping the run. As a result, the Bills were able to exploit the Cards for 208 rushing yards and 6.5 yards per attempt on the way to their 33-18 victory. The Bills' offensive line was generally a step ahead on setting up traps and blocking at the second level.'
Buffalo Bills release kickoff specialist Jordan Gay, add two to practice squad [1:55 AM]
Syracuse Post Standard reports: 'Gay was released by the Bills late in August and added to the team's practice squad in early September. Buffalo promoted Gay to their 53-man roster before their Week 1 matchup against the Baltimore Ravens.'
Who will be Patriots' quarterback against Bills? Rex Ryan thinks he knows [1:54 AM]
Syracuse Post Standard reports: '"I expect them immediately to tell us," Ryan said sarcastically. "As soon as they tell us, we'll be like, 'Yeah, ok.' Nobody would believe it anyway, Nah, I don't know. We're not going to find out until kickoff."'
Patriots 'going to wipe the floor' with Buffalo Bills, says ESPN's Michael Wilbon [1:53 AM]
Syracuse Post Standard reports: '"They're going to wipe the floor with Rex Ryan and the Bills," said Wilbon. "Rex Ryan, (on Sunday), they were great. They were terrific. I thought the Bills would beat Arizona, which is completely overrated. Carson Palmer had about as bad a day as you could have. But the Patriots are going to wipe the floor with the Bills."'
Bills release K Gay [1:52 AM]
The Sports Xchange reports: 'Gay had been used only on kickoffs, and the Bills apparently will now let place-kicker Dan Carpenter handle the kickoff duties as well as the place-kicking chores.'
Bills release Gay, add two to practice squad [1:51 AM]
WGR-AM reports: 'To make room for Eagan and Vaughn on the practice squad, the Bills have released linebacker Carlos Fields and safety Damian Parms.'
Conclusion: Conclusions can wait [1:50 AM]
WGR-AM reports: 'For now just sip on your coffee and watch what happens. Maybe Anthony Lynn will make a big difference. Maybe you can't beat Arizona by two touchdowns unless you really are pretty good. Maybe for the first time since Doug Flutie was their quarterback can the Bills, in New England, win a game the Patriots also care about.'
Bills release K Jordan Gay; Sign two to PS [1:49 AM]
BuffaloBills.com reports: 'The team also announced that it has signed WR Ed Eagan and C Terran Vaughn to the team's practice squad.'
Bills Today: Shaq Lawson on schedule to practice Week 7 [1:48 AM]
BuffaloBills.com reports: '"He's on schedule," said Whaley. "We just had a meeting yesterday so after the six weeks if there are no setbacks he'll be able to start practicing and we'll see where it goes after that. But everything we've heard from the medical staff is that he's ready and raring to go."'
Top 7 storylines for Bills-Patriots this week [1:47 AM]
BuffaloBills.com reports: 'It's likely to be a closely guarded secret all week—the name of the Patriots quarterback starter this week. New England had both Jimmy Garoppolo and Jacoby Brissett on the field during the media portion of their Tuesday practice. Garoppolo is 10 days removed from his sprained AC joint in his shoulder. Brissett reportedly injured his thumb in New England's last game, September 22 against the Texans. But he finished the game and reportedly went through practice with his thumb taped on Tuesday.'
At least for a day, Bills were pretty good [8:49 AM]
Olean Times Herald reports: 'Buffalo prevailed without three key starters – wide receiver Sammy Watkins, offensive tackle Cordy Glenn and cornerback Ronald Darby – and with quarterback Tyrod Taylor enduring a second struggling passing effort in three games.'
Bills' defense showed off aggressive side [1:59 AM]
Buffalo News reports: '"I wanted the opponent to think we weren't going to pressure, either, for that reason," Ryan said Monday. "We thought we had those guys dialed in. We had done it in the past, been very effective against the Jets running a four-man rush. We knew what we were getting, we just didn't really execute quite honestly. But yeah, this opponent was a lot different.'
Blast from the past explains why the Bills defense did first-time OC Anthony Lynn a major favor in S [1:58 AM]
Buffalo News reports: 'The defensive performance really lightened the burden on Lynn, playing so well against the high-powered Cardinals that the Bills offense essentially only needed to avoid an all-time terrible game to earn the victory. Lynn's offense passed that bar with ease.'
Dennis Thurman to continue calling plays [1:57 AM]
Buffalo News reports: '"I want everybody to understand that the responsibility is the same regardless of who the play-caller is," Ryan said. "My input is going to be all over that. So I don't want all of a sudden the criticism to be, oh it's Dennis Thurman. No it's not. It's my defense, it has always been my defense, and that is the way it'll be."'
What They Said: Rex Ryan's Monday Patriots Week press conference [1:56 AM]
Buffalo News reports: 'No. No, we have used that thing before. I don't think we have ever used the four safeties though. We usually, we have used different combinations. That was something I thought would give us a better opportunity to free someone up, maybe change the count up a little bit. So it worked out pretty good. A lot of pressure on the back end to learn those spots and quite honestly we were going to have Colt Anderson back up a bunch of things but then he couldn't go later in the week.'
Three up, three down following Bills' Week Three win over Arizona [1:55 AM]
Buffalo News reports: 'Zach Brown -- The Bills' inside linebacker is making the absence of Reggie Ragland much easier for the defense to deal with. Brown led Buffalo with a dozen tackles Sunday, doing so in just 49 defensive snaps as the team used a specialty package with seven defensive backs for part of the game.'
Strong Fox telecast of Bills game is weirdly and surprisingly worth a second look [1:54 AM]
Buffalo News reports: 'You notice a lot more things watching the game on television than in person but the experience had one thing in common. Fans in the stands were concerned the Bills would blow the game even with a 17-point fourth-quarter lead. Johnston was suggesting it was possible, too, even with about three minutes left. Perhaps that was because he is a Western New York native and knows the team's history as well as any network announcer.'
Bills Review: Give embattled Rex Ryan a little credit [1:53 AM]
Rochester D&C reports: 'There was no doubt that the Bills were embarrassed by what happened against the Jets, and you have to give credit to Ryan and defensive staff for constructing a game plan that had Carson Palmer scratching his head.'
Bills' Tyrod Taylor had worst QB rating of career against Cardinals, but does it matter? [1:52 AM]
Syracuse Post Standard reports: 'There's nothing inherently wrong with how Taylor and the Bills won against the Titans in 2015 or the Cardinals on Sunday. The combination of an outstanding running game and dominant defense will win plenty of games. At some point, though, Taylor has to show he can win games with his arm, too.'
Rob Ryan also deserves credit for Buffalo Bills domination of Arizona Cardinals [1:51 AM]
Syracuse Post Standard reports: 'Thurman did a nice job of keeping the Cardinals off-balance and his play-calling resulted in five sacks and four Carson Palmer interceptions. While Thurman deserves his fair share of praise, Rob Ryan may also deserve some credit for slowing down the Cardinals.'
Rex Ryan gives Bill Belichick impression, heaps praise on New England Patriots [1:50 AM]
Syracuse Post Standard reports: '"Brady's probably the best player in the league, so it's hard to replace players like that, but they're a team," Ryan said. "They've always been built as a team anyway. It has been impressive."'
Bills have confidence back after 1st win [1:49 AM]
AP reports: '"Our guys did a really good job mentally in preparing for that system ... If you thought the Fitz thing was bad, imagine what it would have looked like with Carson Palmer. So we weren't going to live that nightmare again."'
Bills' defense steps up to challenge vs. Cardinals [1:48 AM]
The Sports Xchange reports: '"It was fun out there for the defense," said cornerback Stephon Gilmore, who had two of Buffalo's four interceptions. "We were flying around. We had a great week of practice. We did our thing."'
Rex Ryan on Patriots: 'If Belichick's playing QB, we're coming after him' [1:47 AM]
ESPN reports: '"I know how difficult it is to defend against a running quarterback," Ryan said. "That's what we have to be ready [for] in case Edelman quarterbacks, right? I have a funny feeling he isn't going to be Brady back there."'
Rex Ryan.... delegator? [1:46 AM]
WGR-AM reports: 'This comes on the heels of Ryan sitting in on offensive meetings last week with new coordinator Anthony Lynn and his staff, something Rex had not done under former coordinator Greg Roman before he was fired. Ryan took that a step further Sunday, listening - and even helping - on the headsets when Lynn and the offense had the ball.'
Wood happy with offensive turnaround [1:45 AM]
WGR-AM reports: '"He was open to input from the players, he was a player himself, so he knows that players have info on what they want in the game," Wood said. "They're going to take a little more ownership of the offense, I think he did that as the week went on, the players had a voice... I thought Anthony did a great job. It was an awesome first game plan for him."'
Early season saver [1:44 AM]
WGR-AM reports: 'But let's not get ahead of ourselves. We'll have all week to consider the Bills chances of beating the Patriots on the road. The win over Arizona featured a couple of things that had been lacking so far in 2016. Tyrod Taylor hurt Arizona with his legs early and then the rest of the Bills running game got going. Also, the defense found a quarterback they could harass in the pocket. Carson Palmer looked off pretty much from start to finish Sunday. Palmer generally is not a guy who you see getting rid the of the ball quickly. The Bills defense under Rex Ryan has had a tough time with quarterbacks who get it out of there fast. So Palmer provided a nice matchup for the Bills defense and they did a good job on him.'
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Yebda doubts England duo
Algeria midfielder questions Gerrard and Lampard partnership
Last Updated: 20/06/10 2:09pm
Yebda: Not convinced by England
Sky Bet
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Hassan Yebda believes it was clear to see in Algeria's clash with England that Frank Lampard and Steven Gerrard cannot play together.
It has been suggested for a number of years that the two players are too similar to forge a successful partnership in the centre of the field.
Gerrard has often been asked to operate down the left to incorporate a more defensive midfielder alongside Lampard in the middle, but this strategy did not work against Algeria.
Neither player shone in a turgid 0-0 draw on Friday night and Yebda recognises that they are both far more effective at club level.
He said: "Everyone knows Lampard is not the same player in Chelsea and with England. I felt that in the match, I agree.
"I don't know, maybe it's because Gerrard and Lampard have the same style, they can't play together.
"They play at a very different level and I don't know why. Ask (Fabio) Capello.
"If they win the third game they can do something though."
USA test
Algeria could now advance to the last 16 by beating USA in their final Group C game and, although they are expecting a tough test, confidence in the camp is high.
"We're going to try our best to win against United States. They have a good team, good players, so it will be very difficult for them and us," said Yebda.
Midfielder Karim Matmour added: "If Algeria plays to its potential we don't need to worry about our opponents.
"If we play our style of football we can beat anyone."
Medhi Lacen, a midfielder who plays for Racing Santander in Spain, admits he has been impressed by what he has seen from USA.
"I've seen their matches here and they look good," he said. "They showed against Slovenia that they're capable of fighting back."


text:
on January 12, 2014 - 12:01 AM
, updated January 17, 2014 at 11:00 AM
Town of Tonawanda
The annual Winterfest Weekend in the Town of Tonawanda begins Thursday on the dance floor and runs through next Monday, Jan. 20, with a variety of activities held indoors and out.
A dance from 7 to 10 p.m. in the Senior Citizens Center, 291 Ensminger Road, kicks off the activities. A wine sampling will be held there at 7 p.m. Friday; advance tickets, which cost $20, are available at the center and the Youth, Parks & Recreation Department, 299 Decatur Road. Free recreational skating will be held Friday evening in Lincoln Arena from 6:45 to 8:15 p.m.
Lincoln Park will hold a host of outdoor activities Saturday, including hockey games, ice carving and hayrides. Outdoor music, a bonfire and a brief fireworks display also are planned.
Further information is available at all Youth, Parks & Recreation facilities or by calling 831-1001.
Also this week:
• Town Assessor Dave Marrano will be available to answer any questions regarding recent changes to property tax exemption eligibility from 1 to 2:30 p.m. Monday at the Senior Center.
• The Town Board meets at 7:30 p.m. Monday in council chambers at the municipal building, 2919 Delaware Ave. A work session begins at 4 in the second-floor conference room.
• A regular meeting of the Ken-Ton School Board is scheduled for 6:30 p.m. Tuesday in the community room of the Philip Sheridan Building, 3200 Elmwood Ave.
• Kindergarten registration at Holmes and Hoover elementary schools will be held Tuesday through Friday. Parents should call 871-2090 to schedule an appointment at the central registration office in the Ken-Ton School District's administration building, 1500 Colvin Blvd.
• Friday is the deadline to register for a game of NERF tag scheduled for 6:30 to 8:30 p.m. Friday, Jan. 24, at the Ken-Ton Family YMCA, 535 Belmont Ave. The event is open to people ages 5 years and older – including parents. The cost is $5 for members of the YMCA and $10 for program members. Call the YMCA at 874-5051 for further information or to register. Players should bring their own NERF guns and protective gear.


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Mr. Penis
Originally Posted: 2003-12-11 10:58am
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Mr. Penis
Dear Mr. Penis
My condolences on your lack of inspiration as of late, however I know someone who knows someone who might want to make this world a better place for you. Her name is Miss Vagina.
I met Miss Vagina one early evening while sitting in a warm bathtub with Mr. Bubbles pink soap suds surrounding me. I looked down and felt a nice sensation when the washcloth passed by me on the way to the drain. Ohhh. Hello there I said. And from then on, we were best of friends.
Balding although she chooses to be at the moment, she likes to be touched, pursuaded, tickled and even fed. She prefers one big meal as opposed to several small short meals. Toothpicks are not necessary as Miss Vagina wears dentures lol Vagina comes with me where ever I go. Quite the companion on cold lonely nights in the city. Last week she was sick and I nursed her back to health although I have to say....we need to keep her away from red food coloring.
Mr Penis should be quite impressed as this Vagina is not like the rest of them or like the slutty other relatives in Ohio called the Vagabond Vagina clan who hang around all stubbly and unshowered. They spit and chew anything in sight while Miss Vagina remains to be seen as one of the purest in the family.
She laughs while watching Taebo, is scared of crothety old Mr. Penises who hoot and hollar at her from across the street, She has a black lace fetish and adorns herself in precious European scents from France, Spain and Italy.
Miss vagina truly is my best friend and I am willing to let you get to know her...but of course I do need to approve first. After all that is what best friends do. Pics are nice! And god damn put some clothes on. Miss vagina isnt going ot send you naked ass pictures of herself so neither should you!
post id: 20722465
email to friend
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Yasiel Puig Has Slowed Down But He's Still Good
Much of The Legend Of Yasiel Puig was built during his incredible first month in the majors, as the 22-year-old outfielder debuted on June 3 and hit a ridiculous .443 with eight homers and a 1.218 OPS for the Dodgers through July 2.
He?s come back down to earth in a big way since then, but here?s the thing: Even if you ignore that crazy first 30 days in the majors Puig has been really, really impressive for a rookie. Dating back to July 3 he?s played 60 games and hit .291 with eight homers and an .840 OPS.
Source: Hardball Talk


text:
The Next Chapter Begins: Spredfast Raises $18m in Venture Capital
The Spredfast story is grounded in our customers"™ journey to connect their brands to the social web. I"™m continually humbled by the trust our customers place in us. If you are a current Spredfast customer, know we are focused every day on delivering the platform and services you need to be successful. This is all we do. Today begins the next chapter in our journey. I"™d like to welcome Adam Marcus and the OpenView Venture Partners team to the Spredfast family. OpenView is the lead investor in our C round of funding. They join Austin Ventures and InterWest Partners to give us a great set of venture investors. In 2011, I wrote a blog post about the second inning of social. We had just closed our B round of funding and the market was starting to take shape. In that blog post, I talked about how this market was maturing from the perspective of the social networks and the brands that were using social for better business results. The networks were moving to be more open (APIs) and to provide a rich set of marketing and communication opportunities for brands to talk with their customers. The brands were realizing that social required more than just a couple of interns and a custom Facebook Tab. Spredfast was laser focused on what we called the "More, More, More" strategy. How do we help brands engage more of their employees, on more social accounts to have more meaningful conversations? Social was evolving from a land grab for brand presence to a set of "always-on" communication channels. Fast-forward 18 months to today. The second inning of social is over. The Tab is on life support. Social has become pervasive and is now an integral part of how businesses interact with their customers. One of our customers is putting social in every newsroom. Another is bringing social to more than 400 university campuses. And another is developing a rich digital footprint "" with social at the heart "" for every one of their local stores. And virtually every social network has announced a strategic partner program for Social Marketing Platforms like ours. The focus is engagement""all day, every day. The challenge is how to synchronize social with your business. To do this, companies need a scalable platform that will grow and evolve with them to meet, and exceed, the needs of their customers on social. That platform is Spredfast. And we are ready to take this market to the next level.


text:
Anno 2070 Cheats
And if not, will there be one ?
if you have it on steam already then try it and let us know. we created this with gamersgate version so we have no idea if it works on steam. maybe someone who has tried it can speak up.
Thx for reply. Just got the game from gamersgate.
To be safe
Just tested on steam version and it works flawlessly thanks guys for the trainers.
it does not work for me....
i have the steam version
Read the instructions that come with the trainer.
You're doing something wrong, then. Just got the game on steam, confirmed the trainer works flawlessly with the steam version.
Read the instructions that come with the trainer.
yep sorry....
run trainer in admin mode (win7)......
now it works on steam version
thx for help
[Edited by Joker4877, 11/20/2011 3:23:39 AM]
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This project received 3 bids from talented freelancers with an average bid price of $191 USD.Get free quotes for a project like this
Project Budget$100 - $300 USD
Total Bids3
Project Description
We need an ultra creatIve graphics animation design expert who is familar with HTML5. We want this to be viewable on iPad and iPhones or else we would use FLASH.
The idea is to transform the word REVENUE into our company name REUVEN.
Designer must use our website and color scheme as basis for the design. We have a very strong corporate brand and want to keep this animation in line with the brand identity that we have already built.
Project due date May 10th 2012
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For Your Spring Break Listening Pleasure: The Nuge at the Electric Ballroom in October '75
Still waiting for a call from City Hall, which is worth sticking around for. So with some time to kill, let's go to the vaults -- specifically, this gem suggested by a Friend of Unfair Park who's cranked that Frampton set up to 11. Our Friend insists he was there, man, on Halloween night '75 when Ted Nugent played the Electric Ballroom long ago located at the intersection of Industrial and Cadiz.
The occasion was but one month before the release of the former Amboy Duke's first solo record. Which means this is classic Nuge (Derek St. Holmes too) -- a set list consisting not only of "Snakeskin Cowboys" and "Hey Baby" but also a track off Tooth Fang & Claw. No "Stranglehold," though. Still very Dazed & Confused anyhow. Says it was a radio broadcast, though no jocks are audible. What you can hear -- two guitars and a choking amount of sweet-smelling smoke.
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Dritz® My Double Deluxe Dressform (20405)-Small
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BUY ONLINE PICK-UP IN-STORE now available in a store near you.
Pick-up in one of our locations near you.
Additional Information
Learn How to Select the Right Dressform
Get professional fitting results with the Dritz My Double Deluxe Dressform. Specially designed to fit pants, skirts, tops and other types of garments, this dressform helps to give accurate fittings. It comes with 12 adjustment dial wheels for easy mobility. With adjustable back waist length and longer pole, this dressfoam is ideal for professional fashion designers. Simply pin the fabric on this dress foam to create perfect garments.
- Brand: Prym Dritz
- Dimensions: 33 - 41 inches (bust); 26 - 34 inches (waist); 36 - 44 inches (hips); 14 - 16 inches (back waist length); 13.5 inches (neck)
- Off-set center pole for hanging pants. shaped hips, botttom & thighs for fitting pants
- Longer pole to accommodate taller women, wedding dresses and evening gowns
- Extended shoulder for supporting & setting in sleeves. 12 rotating dial wheels at bust, waist & hips
- Adjustments can be made in precise increments. adjustable back waist length
- Adjustable neck with pincushion. pin hem marker. foam-backed nylon cover for easy pinning & marking
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Items shipping from our warehouse ship within 3 business days (Mon-Fri) for standard shipping. If an order is placed on Friday, Saturday or Sunday, it will ship out within 3 business days the following week. Items shipping direct from the manufacturer will take additional processing time and ship separate from the remainder of your order. See our Full Shipping Policy >
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For pricing information, please see our shipping table, shipping prices are based on order total.
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Personalized products can not be returned. Every order is custom printed for the person who ordered it and therefore can not be resold. If you received product that was flawed or damaged, we will be happy to work with you on a case by case basis. Please call 888.739.4120, Mon.-Sat. 9am-7pm EST, to determine return eligibility & process.


text:
Ivy City Gin
I'd say more distillers are willing to be highly transparent about their botanical bill than their grain bill. The team at One Eight Distilling doesn't publicly disclose much of their botanicals, but they will be even more specific than you might expect about their grains. This is interesting, as one of the major contentions of the Craft Spirits movement is that "grain to glass" is the only thing which should qualify as craft*.


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It's simply not fair for the kid.
The Reds conversations must go something like this...
Jocketty to Bruce, "Sorry Jay, but you need to raise that .366 average if you want to make it to the Bigs!"
It's simply not fair for the kid.
The Reds conversations must go something like this...
Jocketty to Bruce, "Sorry Jay, but you need to raise that .366 average if you want to make it to the Bigs!"
80% of the earth is covered by water. The other 20% is covered by Eric Davis.
Um, have you watched any of the home games lately??? The fan boycott is pretty much already happening...
Good point!
80% of the earth is covered by water. The other 20% is covered by Eric Davis.
because at the end of the day, they still are the Chicago Cubs, and they will figure out a way to screw this whole thing up--Marty B.
2014 record:
GABP: 1-0 Wrigley: 1-1
I think Marty is the biggest reason attendance is down. He is the person that most Reds fans get when they don't live in the Cincinnati area. This team hasn't been good but he works for the Reds and he does a poor job of selling the product. If people far away are listening to him and all he's doing is complaining and beating this team down, then people aren't going to pay $3.95 a gallon to drive 2.5-3 hrs for a ballgame. I've enjoyed this series on the radio because I've been able to listen to Kelch (sp?). Marty is a grump old man that is getting hard to listen to, and most fans have adopted his way of thinking when it comes to the Reds.
Don't get me wrong, the product hasn't been good but he's not helping matters. I'm sick of his meaningless opinions, he should just call the game and promote the product. If he wants to have an opinion, he should join Redszone.
I prefer Marty's telling it like it is ways (while he is a lot grumpier in the last few years and how he harps on the same stuff over and again annoys me). He could be better, but I can deal with it. And when he is actually doing the PBP, I think he is about as good as it gets.
To clarify, I am definitely not a Cubs fan. I reread this post and it sounds like I said I am one. This is definitely not the case. I have to work too many hours to be a Cubs fan.
Last edited by EddieMilner; 05-15-2008 at 10:46 AM. Reason: i am not a cubs fan.
just liek everything in life.. people hate hearing from people who tell them like it is..
I don't think Marty tells it like it is. I think Marty tells it how he feels. He's very inconsistent with his comments. This is my first baseball season with XM radio and I would much rather hear someone call the game and try to make it enjoyable to listen to... I think Marty goes overboard with his comments.
We have a three game winning streak going right now and yet people are STILL complaining about stuff. The blown save sucked last night but the walk off win was just incredible and a big boost to the team. Can't we just enjoy the good ride right now and moan and groan about things later!? :thumbdown
"I tried to play golf, but I found out I wasn't very good." -Joey Votto on his offseason hobby search
An MLB.com reporter asked what one thing Votto couldnt do. I cant skate or play hockey, Votto said. Well, I can skate ... but I cant stop.
...the 2-2 to Woodsen and here it comes...and it is swung on and missed! And Tom Browning has pitched a perfect game! Twenty-seven outs in a row, and he is being mobbed by his teammates, just to the thirdbase side of the mound.
"You can't handle the truth!"
Board Moderators may, at their discretion and judgment, delete and/or edit any messages that violate any of the following guidelines: 1. Explicit references to alleged illegal or unlawful acts. 2. Graphic sexual descriptions. 3. Racial or ethnic slurs. 4. Use of edgy language (including masked profanity). 5. Direct personal attacks, flames, fights, trolling, baiting, name-calling, general nuisance, excessive player criticism or anything along those lines. 6. Posting spam. 7. Each person may have only one user account. It is fine to be critical here - that's what this board is for. But let's not beat a subject or a player to death, please.


text:
Kukla's Korner Hockey
NHL Players Alumni Appreciate Paul Kelly
by Paul on 09/13/09 at 10:14 AM ET
Comments (0)
from Kevin Paul Dupont of the Boston Globe,
Thursday night in Toronto, Gordie Howe and (Ted) Lindsay coaxed Kelly into attending an NHL Players Alumni dinner in Toronto, where a banquet room full of retirees treated him to a protracted and boisterous standing ovation. These are guys with a memory, recalling that it was Kelly, in his days as a Boston-based prosecutor, who finally exposed the evil deeds perpetrated against the players by former PA boss Alan Eagleson, sending the Eagle off to the slammer.
All these years later, it seems the players have adopted Eagleson's calculating and tyrannical approach, shooing Kelly off the watch without just cause.
Leave it to the PA. They had the right guy, and they Just Said No. Again.
more plus a mix of NHL topics…
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Let's talk...in Spanish! Boot Camp Level I and II start October 18. Click here for full schedule and to register online today!
The Lakeshore Ethnic Diversity Alliance works to dismantle barriers to ensure people of all ethnic backgrounds have
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English into Latvian
This project received 5 bids from talented freelancers with an average bid price of $113 USD.Get free quotes for a project like this
Skills Required
Project Budget$30 - $250 USD
Total Bids5
Project Description
Urgent project, app. 2800 word to be translated from English into Latvian asap! We need it within 8 hours.
If you can work fast please get in touch.
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