text:
Bank Insurance Fund:
Review of Loss Estimation Methodologies
AIMD-94-48: Published: Dec 9, 1993. Publicly Released: Jan 10, 1994.
Additional Materials:
- Full Report:
(202) 512-4800
Pursuant to a congressional request, GAO reviewed certain public and private-sector estimates of bank failures and related losses incurred by the Bank Insurance Fund (BIF), focusing on the: (1) various approaches used by these forecasters in estimating bank failures and losses; and (2) similarities, differences, and key assumptions of their estimation methodologies.
GAO found that: (1) the forecasters' BIF loss estimates vary widely because of differing methodologies and assumptions; (2) the forecasters' methodologies share some characteristics such as reliance on professional judgment and banks' unaudited quarterly reports of their financial condition and income; (3) the methodologies significantly differ in their use of data from sources other than call reports, assumptions, the way BIF losses are estimated from future resolution activity, and the time periods on which the projections are based; (4) bank failure estimates and their impact on BIF are uncertain because of their dependence on unpredictable events and forecasters' incomplete disclosure of their methodologies; (5) the Federal Deposit Insurance Corporation (FDIC) is in the best position to provide meaningful loss estimates because of its access to information on the actual costs of bank failure resolutions; and (6) FDIC needs to maintain a well-capitalized BIF because of the uncertainties in long-range loss estimates.
Jul 25, 2016
Mortgage Servicing:Community Lenders Remain Active under New Rules, but CFPB Needs More Complete Plans for Reviewing RulesGAO-16-448: Published: Jun 23, 2016. Publicly Released: Jul 25, 2016.
Jul 5, 2016
Troubled Asset Relief Program:Most Community Development Capital Initiative Investments Remain OutstandingGAO-16-626: Published: Jul 5, 2016. Publicly Released: Jul 5, 2016.
May 6, 2016
Troubled Asset Relief Program:Capital Purchase Program Largely Has Wound DownGAO-16-524: Published: May 6, 2016. Publicly Released: May 6, 2016.
Apr 21, 2016
Financial Institutions:Fines, Penalties, and Forfeitures for Violations of Financial Crimes and Sanctions RequirementsGAO-16-297: Published: Mar 22, 2016. Publicly Released: Apr 21, 2016.
Apr 18, 2016
Federal Real Property:Commodity Futures Trading Commission Needs Better Leasing Guidance to Improve Cost-effectivenessGAO-16-434: Published: Apr 18, 2016. Publicly Released: Apr 18, 2016.
Apr 12, 2016
Resolution Plans:Regulators Have Refined Their Review Processes but Could Improve Transparency and TimelinessGAO-16-341: Published: Apr 12, 2016. Publicly Released: Apr 12, 2016.
Mar 28, 2016
Financial Regulation:Complex and Fragmented Structure Could Be Streamlined to Improve EffectivenessGAO-16-175: Published: Feb 25, 2016. Publicly Released: Mar 28, 2016.
Mar 8, 2016
Troubled Asset Relief Program:Treasury Should Estimate Future Expenditures for the Making Home Affordable ProgramGAO-16-351: Published: Mar 8, 2016. Publicly Released: Mar 8, 2016.
Feb 16, 2016
International Remittances:Money Laundering Risks and Views on Enhanced Customer Verification and Recordkeeping RequirementsGAO-16-65: Published: Jan 15, 2016. Publicly Released: Feb 16, 2016.
Jan 27, 2016
Banking:Federal Agencies' Compliance with Section 302 of the Riegle Community Development and Regulatory Improvement ActGAO-16-213R: Published: Jan 27, 2016. Publicly Released: Jan 27, 2016.
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Product Description
Door Window Bracket Set for 1969-1970 Mustangs with Bolt-In Door Glass.This complete set of brackets is for use with 69-70 Mustangs using bolt-in style door glass or to help convert 69 Mustangs with glue-in glass to bolt-in style. Does both doors.
Similar Mustang PartsMore Body & Sheet Metal
Installation Instructions
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Product Questions
so I'm trying to buy this product but i don't need the two sets i only need one. do you sell that one set itself?
No, they aren't available individually.
Date published: 2015-07-08
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text: r Kimbamor | Digital Scrapbooking at Scrapbook Flair Home Galleries Groups Challenges Blogs Forums Members Downloads MarketPlace Store Archive Join Login offline Joined: Feb 20, 2007 Last Logon: Jul 9, 2008 Kimbamor's Home Page www.scrapbookflair.com/Kimbamor Hi All. I am 39 (till I meet Mickey Mouse), mother of 2, and have been into just about every craft since highschool. The only thing I really can't do it knit or crochet. (Dragon can knit but I can't) Scrap booking is something I picked up along the way. It is funny but I started hoarding things about 7 years ago, before any of the stores in my city even started carrying supplies. My sister moved to the states and when she came back to visit she showed me all her stuff. I thought it was funny because I had this huge pile of stuff I had been working on. It just blossomed from there. Kimbamor is from ON, Canada Kimbamor's Scrapbooks Happiness Is A Warm Puppy Shanna's Fairy Tale True Love email it » view all Kimbamor's scrapbooks Kimbamor's Favorite Scrapbooks » view all Kimbamor's favorite scrapbooks Kimbamor's Friends Kimbamor has 51 friends » view all Kimbamor's friends Kimbamor's Fans Kimbamor has 32 fans » view all Kimbamor's fans Renew/Upgrade Membership Gallery Groups Blog Friends Favorites Tags Post and Share this page on Blogs and other Websites by copying and pasting this link: http://www.scrapbookflair.com/Kimbamor Kimbamor's home page has been visited 1090 times. About Us Bookmark Contact Us Designer Members FAQs Fan Mail Help Link to Us Membership News Privacy Search Site Rules Suggestion Box Tell a Friend © 2006-2016, Patent Pending, Aurora Digital Imaging, Ltd. Beta 5.0 The most fun digital scrapbooking site on the Internet. Free digital scrapbooking software, scrapbook templates, scrapbook embellishments and backgrounds. Beautiful scrapbook prints and photobooks.


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Lacey Brown's "American Idol" days might be over, but the Amarilloan is in high spirits, eager to pursue her music career.
"I'm just excited about the future," she said Thursday. "I'm open to anything and everything right now."
Brown, 24, ended her run on the popular Fox reality show Wednesday.
The songs
What songs did Lacey Brown perform on "American Idol"?
"Landslide" by Fleetwood Mac (Feb. 23)
"Kiss Me" by Sixpence None the Richer (March 3)
"The Story" by Brandi Carlile (March 9)
"Ruby Tuesday" by the Rolling Stones (Tuesday)
Her rendition of the Rolling Stones' "Ruby Tuesday" on the show Tuesday night failed to earn her enough viewer votes to advance in the competition. She was the first of the 12 finalists to be eliminated.
Brown, who answered questions from the media in a conference call Thursday, said she hopes to create a pop-folk album "soon."
"I would love to do that if I get the chance," she said. "There aren't a lot of voices like mine on the radio, so I take pride in the fact that I'm a little bit unique, and I try to embrace that."
The singer said she hopes her "American Idol" experience will give her new chances to share her music.
"This is not the end-all for me," she said. "This is a great opportunity to jump-start my career."
But first, Brown plans to return home.
"I'm very excited to come back and meet some fans and hang out with my family and friends," she said. "But I love that I'm from (Amarillo), and I'm always going to be an Amarillo girl."
She said she'll likely be back in Amarillo next week.
Today, Brown will appear on the "Ellen Degeneres Show" at 4 p.m. on KAMR, Channel 5, according to Melissa Little Padgitt, publicist for the show.
Brown, the daughter of David and Connie Brown, pastor and co-pastor of Victory Church in Amarillo, also competed on the 2009 season of "American Idol."
Last year, she advanced to the Hollywood Week - it's the second round of auditions - before being eliminated. She said she is pleased with her progress this year.
"It's all been a blast for me up to this point," she said. "I'm very proud to be where I'm at."
Brown said she woke up Wednesday morning and "had the strangest feeling" she was going home. "You can be happy with the situation and make the most of it, which is the route I'm trying to take," she said.
Brown said she wouldn't have changed anything about her performances, though she did speculate that her choices to sing slower-tempo songs could have been a factor in her elimination.
"I kept picking songs I loved to sing and really felt. And maybe it didn't transfer as well onstage," she said.
The "American Idol" judges offered Brown positive encouragement, she said.
"All the judges came up afterward. ... They had nothing but nice things to say," she said. "They want to see us (the contestants) succeed, and they don't want us to feel like all hope is lost, because it's not."
The singer thanked her fans and promised to keep her sultry-sweet jazz sound as part of her future projects.
"I just want to give people the chance to hear something that's fresh and new and different," she said. And which "American Idol" contestant will Brown be cheering for now?
"Every one of the contestants are unique and artists in their own right. I can see any of them winning. It's up for grabs," she said. "Someone's got to win it, so we'll see who that is."
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Who was James Foley?
POSTED: 09:16 AM PDT Aug 21, 2014 UPDATED: 08:46 AM PST Nov 13, 2015
James Foley was an American photojournalist who went missing in Syria. Learn more about the life of the man whose his parents call a "martyr for freedom." The man believed to have executed Foley, "Jihadi John," is now believed dead.


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Candy Buffet Favor Bag Kit
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Be sure to add unfilled Favor Bags or boxes on your candy buffet table. Display them at the start of the candy buffet table so the guests can fill their favor with their favorite candy treats. Guests can use them during the reception and fill up again before they leave to take home. Included with the favors is a pre-printed ?Thank You? sticker.
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Corrugated cardboard for strength and stability.
Strict testing standards ensure that these Disposable Decorating Bags from Wilton hold up during decorating, minimizing bag breakage.
- Feels more comfortable in hands as you decorate
- Durable and microware safe
- Convenient, simply use then dispose
- Ideal for most decorating projects
The flexibility of the proprietary blend of materials in the plastic makes the bags feel more comfortable in your hands as you decorate. The bags are even microwave-safe, making them handy for melting and decorating with Candy Melts candy. The uncut ends of the bag make it easy for you to cut them to fit any size tip or to insert a coupler so you can easily switch tips on the same bag of icing. No need to clean the bags; simply use and toss. These sturdy Disposable Decorating Bags are handy for when your decorating needs include many colors of icing or icing in two different consistencies; just fill several bags and you're ready to go!
Individually decorated cupcakes are the perfect way to add a personal touch to celebrations. Now, with Cupcakes 'N More, you have the perfect way to serve them! The look is fresh and fun, featuring bold silver-finished wire spirals to securely hold each cupcake. The twisting, towering design is perfect for any setting-showers, kids' birthdays, weddings, holidays, graduation parties and more. 12 in. high x 13 wide.
Its extra-wide, smooth design is perfect for covering cakes with rolled fondant. The non-stick surface makes handling large pieces of fondant easy; just dust the surface with confectioner's sugar and roll out fondant to the size you need, then use the 20 Inch Fondant Roller to lift the fondant from your work surface to the cake.
Be ready for any celebration with this easy-to-personalize disposable stand! Just assemble, using the instructions included, and then decorate the scalloped border strips with a message and your favorite accents. Holds up to 24 cupcakes.
Decorate the wedding aisle with a floral runner that adds a touch of elegance to the wedding ceremony. Aisle Runner also ensures that the bride's dress stays clean on the walk down the aisle! With pull cord for even unrolling; runner measures 100 ft. long x 36 in. wide.


text:
He Hideth My Soul
|A wonderful Savior is Jesus my Lord,
A wonderful Savior to me;
He hideth my soul in the cleft of the rock,
Where rivers of pleasure I see.
|He hideth my soul in the cleft of the rock
That shadows a dry, thirsty land;
He hideth my life in the depths of His love,
And covers me there with His hand,
And covers me there with His hand.
|A wonderful Savior is Jesus my Lord,
He taketh my burden away;
He holdeth me up and I shall not be moved,
He giveth me strength as my day.
|With numberless blessings each moment He crowns,
And, filled with His fulness divine,
I sing in my rapture, oh, glory to God,
For such a Redeemer as mine!
|When clothed in His brightness, transported I rise
To meet Him in clouds of the sky,
His perfect salvation, His wonderful love,
I'll shout with the millions on high.
Springdale, Arkansas, United States
Imphal, Manipur, India
His perfect salvation, His wonderful love,
I'll shout with the millions on high.
London, England, United Kingdom
Thank God!!! What a wonderful Saviour we have. He takes our burdens and sins away! He hides us from troubles of life and covers us with His hands and His blood. He gives us strength and we shall not be afraid nor be moved. Thanks for uploading this song and God bless you all. Shalom!!!
Kolkata, India
It makes me tearful in joy with Him.
Lagos, Nigeria
This song makes me to shed tears of joy. What a Savior! What a love! It is so deep that none can fathom. I love you so so much my Savior and Redeemer.
Roseburg, Oregon, United States
He hideth my life in the depths of His love, and covers me with His hand. Is that love, OR WHAT!
London, United Kingdom
What a Savior is Jesus to me. He is my Refuge, Protector and strong Tower, shielding me from every storm of life. I praise and worship Him. WHAT A SAVIOR.
Bedford, Texas, United States
Praise God for His wonderful Love Faithfulness and saving, keeping and Eternal power. He will be here SOON!!!!
London, United Kingdom
What a wonderful Saviour is Jesus my Lord! I love Him! May His heart desire be satisfied forever and ever Amen!
Nairobi, Kenya
This song always gives me hope of the assurance of the matchless love of God towards me a sinner. He gives me strength as my days are.


text:
Most Cited International Immunopharmacology Articles
The most cited articles published since 2011, extracted from Scopus.
Myeloid derived suppressor cells in human diseasesTim F. Greten | Michael P. Manns | Firouzeh Korangy
Volume 11, Issue 7, July 2011, Pages 802-806
Myeloid derived suppressor cells (MDSC) have been described as a heterogeneous cell population with potent immune suppressor function in mice. Limited data are available on MDSC in human diseases. Interpretation of these data is complicated by the fact that different markers have been used to analyze human MDSC subtypes in various clinical settings. Human MDSC are CD11b +, CD33 +, HLA-DR neg/low and can be divided into granulocytic CD14 - and monocytic CD14 + subtypes. Interleukin 4Rα, VEGFR, CD15 and CD66b have been suggested to be more specific markers for human MDSC, however these markers can only be found on some MDSC subsets. Until today the best marker for human MDSC remains their suppressor function, which can be either direct or indirect through the induction of regulatory T cells. Immune suppressor activity has been associated with high arginase 1 and iNOS activity as well as ROS production by MDSC. Not only in murine models, but even more importantly in patients with cancer, different drugs have been shown to either reverse the immune suppressor function of MDSC or directly target these cells. Systemic treatment with all-trans-retinoic acid has been shown to mature human MDSC and reverse their immune suppressor function. Alternatively, MDSC can be targeted by treatment with the multi-targeted receptor tyrosine kinase inhibitor sunitinib. This review will provide a comprehensive summary of the recent literature on human MDSC.
Triptolide and its expanding multiple pharmacological functionsQiuyan Liu
Volume 11, Issue 3, March 2011, Pages 377-383
Triptolide, a diterpene triepoxide, is a major active component of extracts derived from the medicinal plant Tripterygium wilfordii Hook F (TWHF). Triptolide has multiple pharmacological activities including anti-inflammatory, immune modulation, antiproliferative and ctyproapoptotic activity. So, triptolide has been widely used to treat inflammatory diseases, autoimmune diseases, organ transplantation and even tumors. Triptolide cannot only induce tumor cell apoptosis directly, but can also enhance apoptosis induced by cytotoxic agents such as TNF-α, TRAIL and chemotherapeutic agents regardless of p53 phenotype by inhibiting NFκB activation. Recently, the cellular targets of triptolide, such as MKP-1, HSP, 5-Lox, RNA polymerase and histone methyl-transferases had been demonstrated. However, the clinical use of triptolide is often limited by its severe toxicity and water-insolubility. New water-soluble triptolide derivatives have been designed and synthesized, such as PG490-88 or F60008, which have been shown to be safe and potent antitumor agent. Importantly, PG490-88 has been approved entry into Phase I clinical trial for treatment of prostate cancer in USA. This review will focus on these breakthrough findings of triptolide and its implications. © 2011 Elsevier B.V.
The role of chalcones in suppression of NF-κB-mediated inflammation and cancerVivek R. Yadav | Sahdeo Prasad | Bokyung Sung | Bharat B. Aggarwal
Volume 11, Issue 3, March 2011, Pages 295-309
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2′,4′- dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review. © 2010 Elsevier B.V.
Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans CantorFanghua Qi | Anyuan Li | Yoshinori Inagaki | Norihiro Kokudo | Sumihito Tamura | Munehiro Nakata | Wei Tang
Volume 11, Issue 3, March 2011, Pages 342-349
The skin of the toad Bufo bufo gargarizans Cantor is known to be rich in bufadienolides, peptides and alkaloids. It has been found to be a source of some extracts and biologically active compounds with antitumor activity. Cinobufacini (Huachansu), a Chinese medicine prepared from the dried toad skin, has been widely used in clinical therapy for various cancers in China. Bufadienolides, such as bufalin, cinobufagin, resibufogenin, and telocinobufagin, are the major active compounds derived from the toad skin. They are the maker biologically active compounds of cinobufagin while the antitumor activity of cinobufagin may be due to this kind of components. Experimental research has suggested that cinobufacini and its active compounds (e.g. bufalin and cinobufagin) exhibit significant antitumor activity, including inhibition of cell proliferation, induction of cell differentiation, induction of apoptosis, disruption of the cell cycle, inhibition of cancer angiogenesis, reversal of multi-drug resistance, and regulation of the immune response. Clinical data have indicated that cinobufacini may have effective anticancer activity with low toxicity and few side effects. Data to date suggest it may also enhance quality of life for patients with cancer. Thus, this review briefly summarizes recent studies on the anticancer activity of cinobufacini and some of its active compounds from the skin of the toad Bufo bufo gargarizans Cantor. This might provide additional evidence for further study of the extracts and active compounds from the toad skin in cancer treatment. © 2010 Elsevier B.V.
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapyMasahiro Ishizuka | Fuminori Abe | Yuki Sano | Kiwamu Takahashi | Katsushi Inoue | Motowo Nakajima | Takeo Kohda | Naoki Komatsu | Shun Ichiro Ogura | Tohru Tanaka
Volume 11, Issue 3, March 2011, Pages 358-365
Early detection and intervention are needed for optimal outcomes in cancer therapy. Improvements in diagnostic technology, including endoscopy, photodynamic diagnosis (PDD), and photodynamic therapy (PDT), have allowed substantial progress in the treatment of cancer. 5-Aminolevulinic acid (ALA) is a natural, delta amino acid biosynthesized by animal and plant mitochondria. ALA is a precursor of porphyrin, heme, and bile pigments, and it is metabolized into protoporphyrin IX (PpIX) in the course of heme synthesis. PpIX preferentially accumulates in tumor cells resulting in a red fluorescence following irradiation with violet light and the formation of singlet oxygen. This reaction, utilized to diagnose and treat cancer, is termed ALA-induced PDD and PDT. In this review, the biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed. © 2010 Elsevier B.V.
Immunomodulatory and therapeutic activity of curcuminRaghvendra M. Srivastava | Sarvjeet Singh | Shiv K. Dubey | Krishna Misra | Ashok Khar
Volume 11, Issue 3, March 2011, Pages 331-341
Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in-vivo studies have provided strong evidence towards the therapeutic potential of curcumin. These studies have also identified a plethora of biological targets and intricate mechanisms of action that characterize curcumin as a potent 'drug' for numerous ailments. During inflammation the functional influence of lymphocytes and the related cross-talk can be modulated by curcumin to achieve the desired immune status against diseases. This review describes the regulation of immune responses by curcumin and effectiveness of curcumin in treatment of diseases of diverse nature. © 2010 Elsevier B.V.
Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and FisetinMegumi Funakoshi-Tago | Kei Nakamura | Kenji Tago | Tadahiko Mashino | Tadashi Kasahara
Volume 11, Issue 9, September 2011, Pages 1150-1159
Flavonoids are widely distributed in many fruits and plants, and it has been shown that most flavonoids have anti-inflammatory activity; however, the mechanisms of how the flavonoids exhibit their anti-inflammatory activity have not been clarified. We therefore focus on flavonoids Apigenin, Luteolin and Fisetin because of their related structure. We found that these compounds significantly inhibited TNFα-induced NF-κB transcriptional activation; however, they had no effect on the degradation of IκB proteins and the nuclear translocation and DNA binding activity of NF-κB p65. Interestingly, the suppression of NF-κB activation by these flavonoids is due to inhibition of the transcriptional activation of NF-κB, since the compounds markedly inhibited the transcriptional activity of GAL4-NF-κB p65 fusion protein. In addition, while Apigenin and Luteolin slightly inhibited TNFα-induced JNK activation, they had no effect on TNFα-induced activation of ERK and p38. Unexpectedly, Fisetin enhanced and sustained activation of ERK and JNK but not p38 in response to TNFα. Strikingly, TNFα-induced expression of CCL2/MCP-1 and CXCL1/KC was significantly inhibited by Apigenin and Luteolin but not Fisetin. Furthermore, the administration of Apigenin and Luteolin markedly inhibited acute carrageenan-induced paw edema in mice; however, Fisetin failed to have an effect. These observations strongly suggest that the slight structural difference in flavonoids may cause a defective effect of Fisetin on these inflammatory responses, and this may be due to the differences in their direction of the effect on the activation pathways of MAP kinases. © 2011 Elsevier B.V.
Neutrophil cell surface receptors and their intracellular signal transduction pathwaysKrisztina Futosi | Szabina Fodor | Attila Mócsai
Volume 17, Issue 3, September 2013, Pages 638-650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue damage during autoimmune and inflammatory diseases. Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment. Those include G-protein-coupled chemokine and chemoattractant receptors, Fc-receptors, adhesion receptors such as selectins/selectin ligands and integrins, various cytokine receptors, as well as innate immune receptors such as Toll-like receptors and C-type lectins. The various cell surface receptors trigger very diverse signal transduction pathways including activation of heterotrimeric and monomeric G-proteins, receptor-induced and store-operated Ca2 + signals, protein and lipid kinases, adapter proteins and cytoskeletal rearrangement. Here we provide an overview of the receptors involved in neutrophil activation and the intracellular signal transduction processes they trigger. This knowledge is crucial for understanding how neutrophils participate in antimicrobial host defense and inflammatory tissue damage and may also point to possible future targets of the pharmacological therapy of neutrophil-mediated autoimmune or inflammatory diseases. © 2013 The Authors.
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathwaysYu Wen Su | Wen Fei Chiou | Shiou Huei Chao | Meng Hwan Lee | Chien Chih Chen | Ying Chieh Tsai
Volume 11, Issue 9, September 2011, Pages 1166-1172
Angelica sinensis (AS), an herb used in traditional Chinese medicine, is thought to have anti-inflammatory activities. Ligustilide is its most abundant ingredient. This study sought to determine ligustilide's effects on lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. Ligustilide significantly suppressed the production of nitric oxide (NO), prostaglandin E 2 (PGE 2) and tumor necrosis factor-α (TNF-α). The inhibition of NO was concomitant with a decrease in the protein and mRNA levels of LPS-induced nitric oxide synthase (iNOS). Furthermore, activation of activator protein-1 (AP-1) and nuclear factor κB (NF-κB) in the nucleus and the cytosolic degradation of IκBα were abrogated by ligustilide. Ligustilide also inhibited the phosphorylation of IκB kinase (IKK) and mitogen-activated protein kinases (MAPKs), including p38 MAPK, extracellular signal-regulated kinase (ERK1/2) and c-Jun N-terminal kinase (JNK). The intracellular reactive oxygen species (iROS) level was also significantly decreased. These results suggest that ligustilide exhibits anti-inflammatory activities by blocking the activation of MAPKs/IKK and the downstream transcription factors AP-1 and NF-κB, which may result from ligustilide's down-regulation of iROS production. © 2011 Elsevier B.V.
MDSC in autoimmunityJames G. Cripps | James D. Gorham
Volume 11, Issue 7, July 2011, Pages 789-793
Myeloid derived suppressor cells (MDSC) were first described nearly two decades ago. Until recently, however, descriptions of MDSC populations were found almost exclusively in animal models of cancer or in cancer patients. Over the last few years, an increasing number of reports have been published describing populations of myeloid cells with MDSC-like properties in murine models of autoimmune disease. In contrast to the proposed deleterious role of MDSC in cancer - where these cells likely inhibit tumor immunity - in the context of autoimmunity, MDSC have the potential to suppress the autoimmune response, thereby limiting tissue injury. A logical corollary of this hypothesis is that a failure of endogenous MDSC to appropriately control autoimmune T cell responses in vivo may actually contribute to the pathogenesis of autoimmune disease. © 2011 Elsevier B.V. All rights reserved.
Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathwaysShimei Qi | Yinqiang Xin | Yingtao Guo | Ying Diao | Xianjuan Kou | Lan Luo | Zhimin Yin
Volume 12, Issue 1, January 2012, Pages 278-287
Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin significantly inhibited the release of nitric oxide (NO) and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in a dose-dependent manner. Consistent with NO inhibition, ampelopsin suppressed lipopolysaccharide (LPS)-induced expression of inducible NO synthase (iNOS) by inhibiting nuclear factor κB (NF-κB) activation, which highly correlated with its inhibitory effect on IκB kinase (IKK) phosphorylation, IκB phosphorylation and NF-κB nuclear translocation. Further study demonstrated that ampelopsin suppressed LPS-induced activation of Akt without effecting mitogen-activated protein kinases (MAPKs) phosphorylation. A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IκB/NF-κB-mediated iNOS gene expression. Finally, we certificated that ampelopsin reduced reactive oxygen species (ROS) accumulation and an anti-oxidant N-acetyl-L-cysteine (NAC) significantly repressed LPS-induced PI3K/Akt phosphorylation and the downstream IKK/IκB activation. NAC thereby inhibited LPS-induced iNOS expression and NO production. The present results suggest that the anti-inflammatory effect of ampelopsin is due to inhibiting the interconnected ROS/Akt/IKK/NF-κB signaling pathways. © 2011 Elsevier B.V. All rights reserved.
FOXP3 and RORγt: Transcriptional regulation of Treg and Th17Zuojia Chen | Fang Lin | Yayi Gao | Zhiyuan Li | Jing Zhang | Yue Xing | Zihou Deng | Zhengju Yao | Andy Tsun | Bin Li
Volume 11, Issue 5, May 2011, Pages 536-542
FOXP3+CD4+CD25+ Regulatory T (Treg) cells and IL-17 producing helper T cells (Th17) are critical subsets of T cells which play essential roles in immune homeostasis. The Forkhead family transcription factor FOXP3 is predominantly expressed in Treg cells, where the FOXP3 ensemble is essential for Treg cell development and function. As FOXP3 is to Treg cells, the orphan retinoic acid nuclear receptor (ROR) family transcription factor RORγt is essential for Th17 development and function. In this review, we summarize recent progress of our understanding towards the molecular mechanisms underlying the differentiation and function of FOXP3+ Treg cells and RORγt expressing Th17 cells. These may provide new insights into therapeutic intervention and targeting of human immune-deficient diseases. © 2010 Elsevier B.V.
Toll-like receptors in inflammation of the central nervous systemYan Kong | Yingying Le
Volume 11, Issue 10, October 2011, Pages 1407-1414
Toll-like receptors (TLRs) belong to pattern-recognition receptor family that could recognize exogenous pathogen-associated molecular patterns and endogenous damage-associated molecular patterns. TLRs play pivotal roles in innate and adaptive immune responses. In this review we summarize the ligands and signal transduction pathways of TLRs and highlight recent progress of the involvement of TLRs in neuroinflammation related disorders, including cerebral ischemia/stroke, brain trauma and hemorrhage, pathogen infection and autoimmune diseases, and explore the potential of TLR signaling as therapeutic targets against these disorders. © 2011 Elsevier B.V. All rights reserved.
Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathwayYing Liu | Hao Wu | Yi Chu Nie | Jia Ling Chen | Wei Wei Su | Pei Bo Li
Volume 11, Issue 10, October 2011, Pages 1606-1612
Naringin has been reported as an effective anti-inflammatory compound. We previously showed that naringin had antitussive effect on experimentally induced cough in guinea pigs. However, the effects and mechanism of naringin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice are not fully understood. In this study, our aim was to evaluate the anti-inflammatory activities of naringin on LPS-induced ALI in mice and clarify its underlying mechanisms of action. We found that in vivo pretreatment with naringin markedly decreased the lung wet weight to dry weight ratio, and led to significant attenuation of LPS-induced evident lung histopathological changes. Meanwhile, naringin significantly reduced bronchoalveolar lavage fluid (BALF) total cell and neutrophil (PMN) counts after LPS challenge. Furthermore, naringin inhibited myeloperoxidase (MPO: a marker enzyme of neutrophil granule) and inducible nitric oxide synthase (iNOS) activities in lung tissue and alleviated LPS-induced tumor neurosis factor-α (TNF-α) secretion in BALF in a dose-dependent manner. Additionally, Western blotting showed that naringin efficiently blunt NF-κB activation by inhibiting the degradation of IKB-α and the translocation of p65. Taken together, these results suggest that naringin shows anti-inflammatory effects through inhibiting lung edema, MPO and iNOS activities, TNF-α secretion and pulmonary neutrophil infiltration by blockade of NF-κB in LPS-induced ALI. © 2011 Elsevier B.V. All rights reserved.
Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophagesHyo Jin An | In Tae Kim | Hee Juhn Park | Hyung Min Kim | Jung Hye Choi | Kyung Tae Lee
Volume 11, Issue 4, April 2011, Pages 504-510
We previously reported that extract of Rosa rugosa root and its active triterpenoids constituents exhibit anti-nociceptive and anti-inflammatory effects in animal models. However, little is known about the effects and the molecular mechanism of the 19α-hydroxyursane-type triterpenoids. Among the tested 19α-hydroxyursane-type triterpenoids (kaji-ichigoside F 1, rosamultin, euscaphic acid, tormentic acid (TA)), TA was found to most potently inhibit the production of nitric oxide (NO) in RAW 264.7 cells. We investigated the anti-inflammatory effects and its underlying molecular mechanisms of TA in lipopolysaccaride (LPS)-stimulated RAW 264.7 cells. TA dose-dependently reduced the productions of NO, prostaglandin E2 (PGE2), and tumor necrosis factor-α (TNF-α) induced by LPS. In addition, TA significantly suppressed the LPS-induced expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α at the mRNA and protein levels. Moreover, treatment with TA decreased LPS-induced DNA binding of nuclear factor-kappa B (NF-κB) and nuclear translocation of p65 and p50 subunits of NF-κB. Consistent with these findings, TA also suppressed the LPS-stimulated degradation and phosphorylation of inhibitor of kappa B-α (IκB-α). Taken together, these results suggest that the anti-inflammatory activity of TA is associated with the down-regulation of iNOS, COX-2, and TNF-α through the negative regulation of the NF-κB pathway in RAW 264.7 cells. © 2011 Elsevier B.V.
Molecular mechanisms of IgE mediated food allergySandeep Kumar | Alok Kumar Verma | Mukul Das | Premendra D. Dwivedi
Volume 13, Issue 4, August 2012, Pages 432-439
The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also known as immediate type hypersensitivity or type I reaction. This review encompasses a wide range of molecular events during IgE mediated reactions like primary exposure of allergens, processing of allergens by antigen presenting cells, role of transcription factors like GATA-3, STAT-6, NF-AT, c-maf, c-kit and NF-κB, Treg cells, toll like receptors, cytokines and chemokines, class switch to IgE, FcεR1 receptor, priming of IgE on mast cells or basophils, signaling events followed by secondary exposure of allergens, degranulation and release of mediators like leukotrienes, histamines, prostaglandins, β-hexosaminidase and ultimately anaphylaxis. This review may be helpful to beginners as well as experts working in the field of allergy and immunology because of the stepwise explanations of molecular mechanisms involved in IgE mediated reactions. © 2012 Elsevier B.V.
Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cellsJung Min Lee | Jieun Jung | Hyun Jung Lee | Su Jin Jeong | Kyung Jin Cho | Seong Gyu Hwang | Gi Jin Kim
Volume 13, Issue 2, June 2012, Pages 219-224
Mesenchymal stem cells (MSCs) are powerful sources for cell therapy in regenerative medicine because they can be isolated from various tissues, expanded, and induced into multiple-lineages. Of note, their immunomodulatory effects maximize the therapeutic effects of stem cells engrafted on host, making them an especially attractive choice. Recently, several varieties of placenta-derived stem cells (PDSCs) including chorionic plate-derived MSCs (CP-MSCs) have been suggested as alternative sources of stem cells. However, comparative studies of immunomodulatory effects for CP-MSCs among various MSCs are largely lacking. We examined and compared immunomodulatory function of CP-MSCs with that of BM-MSCs and AD-MSCs using co-culture system with activated T-cells derived from human umbilical cord blood (UCB) exposed to anti-CD3 and anti-CD28 which are T-cell activating monoclonal antibodies. All MSCs expressed markers of stem cells and three germ layers by RT-PCR. These cells also exhibited comparable immunomodulatory effects when they were co-cultured with activated T-cells in dose-dependent manner. However, expression of HLA-ABC and HLA-G was highly positive in CP-MSCs compared to other MSCs, and higher levels of cytokines of IL-2, IL-4, IL-13, and GM-CSF were detected in dose-dependent manner in CP-MSCs. Taken together, the results of the present study suggest that while CP-MSCs, BM-MSCs, and AD-MSCs all have immunomodulatory effects, CP-MSCs may have additional advantage over the other MSCs in terms of immunomodulation. In conjunction with other previous studies, CP-MSCs are suggested to be a useful stem cell source in cell therapy. © 2012 Elsevier B.V. All rights reserved.
Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathwayChun Ni Lu | Zi Guo Yuan | Xiao Li Zhang | Ru Yan | Ya Qin Zhao | Ming Liao | Jian Xin Chen
Volume 14, Issue 1, September 2012, Pages 121-126
Saikosaponin a (SSa) and its epimer saikosaponin d (SSd) are major triterpenoid saponin derivatives from Radix bupleuri (RB), which has been long used in Chinese traditional medicine for treatment of various inflammation-related diseases. In the present study, the anti-inflammatory activity, as well as the underlying mechanism, of SSa and SSd was investigated in lipopolysaccharide (LPS)-induced RAW264.7 cells. Our results demonstrated that both SSa and SSd significantly inhibited the expression of inducible nitric-oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-induced RAW264.7 cells, and finally resulted in the reduction of nitric oxide (NO) and prostaglandin E2 (PGE2). In addition, LPS-induced production of major pro-inflammatory cytokines: the tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), was suppressed in a dose-dependent manner by the treatment of SSa or SSd in RAW264.7 cells. Further analysis revealed that both SSa and SSd could inhibit translocation of nuclear factor-κB (NF-κB) from the cytoplasm to the nucleus in the LPS-induced RAW264.7 cells. Furthermore, SSa and SSd exhibited significant anti-inflammatory activity in two different murine models of acute inflammation, carrageenan-induced paw edema in rats and acetic acid-induced vascular permeability in mice. In conclusion, SSa and SSd showed potent anti-inflammatory activity through inhibitory effects on NF-κB activation and thereby on iNOS, COX-2 and pro-inflammatory cytokines. © 2012 Elsevier B.V.
Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanismsGuiyuan Ji | Qinhe Yang | Jing Hao | Lina Guo | Xiang Chen | Jianping Hu | Liang Leng | Zhuoqin Jiang
Volume 11, Issue 6, June 2011, Pages 762-768
Genistein is a naturally occurring plant-derived phytoestrogen present in the human diet, and is known to possess anti-cancer, anti-oxidant and anti-osteoporosis effects. Anti-inflammatory activity of genistein has been revealed in animal studies. In this paper, we investigated the anti-inflammatory effect of genistein on non-alcoholic steatohepatitis (NASH) rats induced by high fat diet (HFD), and explored its potential mechanisms. Rats were fed with normal chow diet or HFD for 12 weeks with or without low (4 mg/kg/day body weight) or high (8 mg/kg/day body weight) dose of genistein. Serum levels of aminotransferases, thiobarbituric acid-reactive substances (TBARS), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and transforming growth factor beta (TGF-β1) were measured, hepatic inflammation, liver TBARS, IL-6, TNF-α and TGF-β1 levels were determined, and proteins involved in mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) pathways were assayed. The results showed that the NASH model rats reproduced typical pathogenetic and histopathological features of NASH in human, and genistein administration improved liver function, slowed down NASH progression, decreased the levels of TBARS, TNF-α and IL-6 in serum and liver, as well as inhibited IκB-α phosphorylation, nuclear translocation of NF-κB p65 subunit, and activation of c-Jun N-terminal kinase (JNK). In conclusion, genistein may be a promising drug to inhibit the inflammatory process and prevent liver damage in patients with NASH. © 2011 Elsevier B.V. All rights reserved.
Toll-like receptors are key players in neurodegenerationDaniela S. Arroyo | Javier A. Soria | Emilia A. Gaviglio | Maria C. Rodriguez-Galan | Pablo Iribarren
Volume 11, Issue 10, October 2011, Pages 1415-1421
The activation of innate immune response is initiated by engagement of pattern-recognition receptors (PPRs), such as Toll-like receptors (TLRs). These receptors are expressed in peripheral leukocytes and in many cell types in the central nervous system (CNS). The expression of TLRs in CNS was mainly studied in astrocytes and microglial cells. However, new evidence indicates that these receptors may play an important role in neuronal homeostasis. The expression of TLRs in the CNS is variable and can be modulated by multiple factors, including pro-inflammatory molecules, which are elevated in neurodegenerative diseases and can increase the expression of TLRs in CNS cells. Moreover, activation of TLRs induces the release of pro-inflammatory cytokines. Therefore, TLRs have been shown to play a role in several aspects of neurodegenerative diseases. Here we will discuss results reported in the recent literature concerning the participation of TLRs in neurodegenerative diseases. © 2011 Elsevier B.V. All rights reserved.
Vaccine candidates for leishmaniasis: A reviewRajeev Nagill | Sukhbir Kaur
Volume 11, Issue 10, October 2011, Pages 1464-1488
Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the genus Leishmania. The clinical manifestation of the disease varies from self-limiting cutaneous lesions to progressive visceral disease. It is estimated that 350 million people are at risk in 88 countries, with a global incidence of 1-1.5 million cases of cutaneous and 500,000 cases of visceral leishmaniasis. The key control measures mainly rely on early case detection and chemotherapy which has been hampered by the toxicity of drugs, side-effects and by the emergence of drug resistance in parasites. Control of reservoir host and vector is difficult due to operational difficulties and frequent relapses in the host. Therefore, the development of effective and affordable vaccine against leishmaniasis is highly desirable. Although considerable progress has been made over the last decade in understanding immune mechanisms underlying potential candidate antigens, including killed, live attenuated parasites, crude parasites, pure or recombinant Leishmania proteins or DNA encoding leishmanial proteins, as well as immunomodulators from sand fly saliva, very few candidate vaccines have progressed beyond the experimental stage. As such there is no vaccine against any form of human leishmaniasis. In recent years, however, much interest has been stimulated towards vaccination against leishmaniasis focused mainly on cutaneous leishmaniasis with fewer attempts against visceral leishmaniasis. © 2011 Elsevier B.V. All rights reserved.
Plant-derived medicines: A novel class of immunological adjuvantsPaul V. Licciardi | John R. Underwood
Volume 11, Issue 3, March 2011, Pages 390-398
Plant-derived medicines have a long history of use for the prevention and treatment of human disease. Today, many pharmaceuticals currently approved by the Food and Drug Administration (FDA) have origins to plant sources. A major role for plant-derived compounds based on the reported immunomodulatory effects has emerged in recent times and has led to the rigorous scientific examination to determine efficacy and safety. The discovery of novel plant compounds with immune system modulating activities has become an increasingly important area of research, particularly in the search for new-generation vaccine adjuvants. This review discusses the important role of plant-derived medicines as immunomodulators and provides evidence in support of the continued investigation of this new class of drugs for the maintenance of human health. The identification and characterization of plant compounds that augment new or existing vaccines, and in particular mucosally administered vaccines, will be of significant interest to vaccinologists and immunologists. © 2010 Elsevier B.V.
Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer propertiesAnlys Olivera | Terry W. Moore | Fang Hu | Andrew P. Brown | Aiming Sun | Dennis C. Liotta | James P. Snyder | Younghyoun Yoon | Hyunsuk Shim | Adam I. Marcus | Andrew H. Miller | Thaddeus W W Pace
Volume 12, Issue 2, February 2012, Pages 368-377
Nuclear factor kappa B (NF-κB) is a key signaling molecule in the elaboration of the inflammatory response. Data indicate that curcumin, a natural ingredient of the curry spice turmeric, acts as a NF-κB inhibitor and exhibits both anti-inflammatory and anti-cancer properties. Curcumin analogs with enhanced activity on NF-κB and other inflammatory signaling pathways have been developed including the synthetic monoketone compound 3,5-Bis(2-fluorobenzylidene)-4-piperidone (EF24). 3,5-Bis(2- pyridinylmethylidene)-4-piperidone (EF31) is a structurally-related curcumin analog whose potency for NF-κB inhibition has yet to be determined. To examine the activity of EF31 compared to EF24 and curcumin, mouse RAW264.7 macrophages were treated with EF31, EF24, curcumin (1-100 μM) or vehicle (DMSO 1%) for 1 h. NF-κB pathway activity was assessed following treatment with lipopolysaccharide (LPS) (1 μg/mL). EF31 (IC 50 ∼ 5 μM) exhibited significantly more potent inhibition of LPS-induced NF-κB DNA binding compared to both EF24 (IC 50 ∼ 35 μM) and curcumin (IC 50 > 50 μM). In addition, EF31 exhibited greater inhibition of NF-κB nuclear translocation as well as the induction of downstream inflammatory mediators including pro-inflammatory cytokine mRNA and protein (tumor necrosis factor-α, interleukin-1β, and interleukin-6). Regarding the mechanism of these effects on NF-κB, EF31 (IC 50 ∼ 1.92 μM) exhibited significantly greater inhibition of IκB kinase β compared to EF24 (IC 50 ∼ 131 μM). Finally, EF31 demonstrated potent toxicity in NF-κB-dependent cancer cell lines while having minimal and reversible toxicity in RAW264.7 macrophages. These data indicate that EF31 is a more potent inhibitor of NF-κB activity than either EF24 or curcumin while exhibiting both anti-inflammatory and anticancer activities. Thus, EF31 represents a promising curcumin analog for further therapeutic development. © 2011 Elsevier B.V. All rights reserved.
A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated miceHui Wang | Mengyu Wang | Jing Chen | Ying Tang | Jie Dou | Jian Yu | Tao Xi | Changlin Zhou
Volume 11, Issue 11, November 2011, Pages 1946-1953
To assess the chemoprotective properties of a polysaccharide from Strongylocentrotus nudus eggs (SEP), myelosuppressed and immunosuppressed mouse models were generated by administration of cyclophosphamide (Cy) and then treated with SEP. SEP (16 mg/kg/d) remarkably increased spleen and thymus indices, activated the proliferation of leukocytes and erythrocytes and platelets from peripheral blood, and exhibited co-mitogenic activity on ConA- or LPS-stimulated splenocytes in a dose-dependent manner. An increased percentage of CD34 + cells in bone marrow of Cy-treated mice was also observed. Furthermore, SEP elevated CD4 + T lymphocyte counts as well as the CD4/CD8 ratio dose-dependently, and it increased interleukin-2 (IL-2), IgA, IgM, and IgG levels in the sera of Cy-treated mice. Pre-incubation with TLR2 and TLR4 blocking antibodies inhibited splenocyte proliferation and its IL-2 secretion. Finally, SEP significantly induced Akt phosphorylation in splenocytes from Cy-treated mice, suggesting that chemoprotection by SEP was mediated through the PI3K/Akt signaling pathway. These findings indicate that SEP plays an important role in the protection against myelosuppression and immunosuppression in Cy-treated mice and could be a potential immunomodulatory agent. © 2011 Elsevier B.V. All rights reserved.
Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathwayK. F. Huang | G. D. Zhang | Y. Q. Huang | Y. Diao
Volume 12, Issue 2, February 2012, Pages 334-341
Wogonin, one of flavonoid compounds isolated from Chinese herbal plants Scutellaria baicalensis Georgi, has been recognized as a potent anti-cancer agent acting through control of growth, differentiation and apoptosis. However, the underlying molecular mechanism of its anti-cancer activity remains to be further elucidated. In this study, we investigated the potential role of wogonin in the induced-apoptosis of human breast cancer cells MCF-7. Wogonin was found to inhibit the proliferation of MCF-7 in a concentration and time-dependent manner, notably wogonin could induce G1 phase arrest of MCF-7 cells. Wogonin-induced apoptosis was accompanied by a significant decrease of the Bcl-2 and survivin and increase of Bax and p53. Wogonin also increased active apoptosis forms of caspases-3, -8, -9 significantly. Z-DEVD-fmk, a specific caspase-3 inhibitor, significantly inhibited wogonin-induced cell apoptosis. Wogonin also suppressed the phosphorylation of PI3K/Akt and induced phosphorylation of ERK. PD98059, a specific ERK inhibitor, significantly blocked wogonin-induced apoptosis. On the other hand, LY294002, a specific PI3K inhibitor, significantly increased wogonin-induced cell apoptosis. Further study indicated that LY294002 not only down-regulated the expression of survivin alone, but also enhanced the inhibition of survivin expression combined with wogonin. In conclusion, the pro-apoptotic effect of wogonin is mediated through the activation of ERK and the activation of caspases, and is correlated with the block of the PI3K/Akt/survivin signal pathways in MCF-7 cells. © 2011 Elsevier B.V. All rights reserved.


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SLIDESHOW: 10 Bargain Metals Stocks You Can Buy Cheaper Than Insiders DidBy Metals Channel Staff, updated Saturday, October 1, 2:54 PM
(3) United States Steel Corp. (NYSE:X) triggered: 08/31/2016
United States Steel is a steel producer of flat-rolled and tubular products. Co. has three operating segments: Flat-rolled Products, which includes the production of slabs, rounds, strip mill plates, sheets and tin mill products, as well as iron ore and coke production; U.S. Steel Europe, which produces and sells slabs, sheet, strip mill plate, tin mill products and spiral welded pipe, as well as heating radiators and refractory ceramic materials; and Tubular Products, which produces and sells seamless and electric resistance welded steel casing and tubing, standard and line pipe and mechanical tubing. Co.'s other business activities consist of railroad services and real estate operations.
X — last trade: $18.86 — Recent Insider Buys:
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As soon as people hear the title ''It's a Wonderful Life,'' it triggers a flood of memories.
Thanks to years when the movie fell into public domain and seemingly every channel except for ESPN and Playboy carried the 1946 film on an endless loop in December, most people have seen the holiday favorite many times and have strong expectations about what a stage production bearing that name should include.
Director Terri Gilbert said the stage version, written by James W. Rodgers, does a good job of presenting that familiar story in a live setting. The play opens Friday for a three-weekend run at Trumbull New Theatre.
''I wanted to do something holiday related, something with a little bigger cast,'' Gilbert said. ''It's a name show that I hoped would draw some interest in the community and with our patrons.''
That last point already is proving to be true. Based on the response when the box office opened to season ticket holders and patrons last week, there is a good chance for sellouts during the show's run.
There might not be a car crash on stage, but Rodgers preserves many of the elements from the movie, which means creating multiple locations on the TNT stage and executing quick set changes.
Fact Box
When You?Go
WHAT: ''It's a Wonderful Life''
WHEN: 8 p.m. Friday, Saturday and Nov. 9-10 and 16-17 and 3 p.m. Nov. 18
WHERE: Trumbull New Theatre, 5883 Youngstown-Warren Road, Niles.
HOW MUCH: $12 adults and $10 students. For reservations or more information, call the TNT box office at 330-652-1103 between 7 and 9 p.m. weekdays.
''Kate Huff has been a big help on the set with scenic design,'' Gilbert said. ''This is a set that you have to get so many different elements, and she has been able to make them pop. She's really been able to help me create the Bedford Falls I knew I wanted.''
The play tells the story of George Bailey, who operates a family-owned savings and loan business. A financial crisis has him pondering suicide until he gets a visit from his guardian angel, Clarence, who shows him what life in Bedford Falls would be like if he never had lived.
When it came to casting, Gilbert said she looked for the best actors, not necessarily the performers who fit the movie characters physically. For example, no one would mistake Warren Municipal Court Judge Thomas Gysegem, who plays Clarence, for the older, feeble Henry Travers from the film.
Rob Morris, who has appeared in several comedies at TNT, takes on the more dramatic challenge of playing George Bailey.
''It's a whole different venue for him,'' Gilbert said. ''At TNT he's really done comedy more, but he has the ability. He's doing a really nice job with being able to find George. He's a minister, and he can draw on life experiences that he's had with parishioners to get the depth of character.''
The rest of the cast includes Gary Roddy, Samuel Darrin, Brett Bunker, JoAnn Winterbauer, Jenny Long, Rene Johntony, Wayne Morlock, Herb Everman, Jerry Kruse, Nicole Bowden, Bill Finley, Art Smallsreed, Molly Lukehart, Margie Johnson, John Timmins, Kathy Purdum, Rene Penn, Michael J. Hill, Micky Burnsworth, Kate Huff, Gunnar Gray, Jim Penn, Abby Deemer and Olivia Gray.


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The library is very well organized and up to date. It house the tutoring center that has increased pass rates.
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Grades can be found online anytime through blackboard. Teachers can be reached in a timely manner using email.
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Everything is close so getting around is no problem also there are wonderful people helping out if anything is needed.
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It's excellent when I need a computer or internet I can always count on theirs to be there at my need.
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April 2-30: $1,300 weekly
April 30- May 21: $1,475 weekly
May 21- June 4: $1,750 weekly
June 4-25: $1,850 weekly
June 25- July 2: $1,995 weekly
July 2- August 27: $2,850 weekly
August 27- Sept 24: $1,950 weekly
Sept 24- Oct 29: $1,800 weekly
After a great day in Acadia National Park, relax and enjoy a barbecue on the back deck or sip a lemonade on the patio of Highbrook cottage. This comfortable cottage is just outside of Bar Harbor, a 15 minute stroll or a 30 second ride on the Island Explorer bus right from the end of the driveway will have you in the midst of downtown in no time. Highbrook has a fully equipped kitchen, cozy living room with woodstove, and master bedroom with large private bath. Upstairs there is a twin bedroom, bedroom with two bunk-beds, a full bath, and a large bedroom with queen bedroom and it's own sitting room that includes a sleeper-sofa.
New in 2015- four new windows, new living room furniture, new hardwood flooring in the dining and living rooms, two new mattresses and working on residing the exterior!
Charcoal grill.
10 fans
4 televisions
No pets allowed.


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Manning Marable is Professor of History and Political Science, and the Director of the Institute for Research in African-American Studies at Columbia University. He is co-founder of the Black Radical Congress, a national network of African-American activists. He is the author of 13 books, most recently Black Leadership (NY: Columbia Univ. Press. 1998).
Globalization And Racialization
The Significance of the Nation's First Elected African American President
African-American Peacemakers – Dr. Martin Luther King, Jr., Barack Obama, and the Struggle Against Racism, Inequality and War
Barack Obama's Problem — And Ours Along the Color Line
Jamaica Today: The Legacy of Michael Manley
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A Humane Society is Possible Through Struggle
The New Racial Domain
In Defense of Black Reparations
The Failure of U.S. Foreign Policies
Public Education and Black Empowerment
Two on the Election
Malcolmology Episode 2: Growing Up Garvey
Malcolmology: Episode 1
Green Party 2000 Convention – Manning Marable plenary speech
African and Caribbean Politics from Kwame Nkrumah to the Grenada Revolution
Beyond Black and White: Transforming African-American Politics
Black Leadership
Blackwater: Historical Studies in Race, Class Consciousness, and Revolution
Race, Politics and Power
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What does CILT mean in Certifications?
This page is about the meanings of the acronym/abbreviation/shorthand CILT in the Business field in general and in the Certifications terminology in particular.
Certificate In Learning And Teaching
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Save on Upper and Lower Level seats for the Dec. 3 concert; the Orange County Register calls it "an overwhelming live experience"
See star impressionist Gordie Brown at the Golden Nugget in Las Vegas, and save 55% on tickets.
Fator is an impressive singer, best known for winning "America's Got Talent"
Penn & Teller's magic show has been called "the most creative, entertaining, intelligent and ... the single best show in Vegas" by the LA Times
It really is "jaw-dropping" (Variety) and "visually stunning" (Las Vegas Sun)
"BAZ: Star-Crossed Love" features music from "Romeo + Juliet" and "The Great Gatsby"
Known for winning the first season of "Randy Jackson Presents America's Best Dance Crew"
"Jukebox" features a mix of pop classics, doo-wop, Motown and soul standards
When we saw Broadway's '80s-themed musical "Rock of Ages" in Las Vegas, the cast had the audience (ourselves included) dancing in their seats
Grab a seat for summer and jet across the country on the 'Best Domestic Airline.'
The show's open-format style means no two performances are ever the same
"Defending the Caveman" has been called "outrageously funny and surprisingly sweet" by the Chicago Sun-Times
This escorted tour visits Grand Canyon, Bryce Canyon and Zion National Parks
Several costumes in the show are created by famous designer Bob Mackie.
Take a break from the Strip and see the beauty of the Southwest and the Grand Canyon.
"Marriage Can Be Murder" is an award-winning interactive comedy and murder-mystery dinner during which the audience members become part of the show
There is no lip-syncing in "Legends in Concert": All artists perform live to a five-piece band
We were dubious at first but left the show feeling pleasantly surprised, which the reviews back up.
Travelzoo members praise the "great food selection and great service" at Pampas on The Strip. Save 55% on an all-you-can-eat rodizio dinner for two.
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Job Overview
Experience your America and build a fulfilling career by joining the National Park Service. Become a part of our mission to unite our past, our cultures and our special places, to establish important connections to the present and build a rich and lasting legacy for future generations. For more information about the National Park Service, click: http://www.nps.gov.
This is a full time temporary position not-to-exceed 1039 hours, duty stationed at Fort Union Trading Post National Historic Site, Williston, North Dakota.
AREA INFORMATION: Fort Union Trading Post National Historic Site is located 25 miles west of Williston, North Dakota (population 12,000), and 26 miles north of Sidney, Montana (population 6,200). Park housing is available for rental, consisting of a shared or single room in seasonal house. Temporary housing difficult to locate in Williston and Sidney. Services such as shopping, schools, hospitals, churches, gyms and city parks are available in both towns.
Area climate has distinct seasons. Winters can be severe, (January-March) temperatures range from -25 F to 40 F, with short periods of severe wind chill and intermittent, dry snow. Summers (June-September) temperatures range from 85-100 with afternoon thunderstorms. Spring and Fall temperatures range from 25 F to 85 F, with increased moisture.
Review the complete job announcement to assure you have submitted all requested documentation. Failure to submit ALL application materials may result in a low or ineligible rating.
Who May Apply: This position is open to all US citizens.
Number of Vacancies: One position will be filled from this job opportunity announcement.
The selectee inventories, catalogues, and processes archeological collections for storage. Removes specimens from storage and re-packs specimens with complete labeling that preserves data associated with the specimens. Organizes collections in storage on shelves or in cabinets as appropriate. Assists in cleaning storage and exhibit areas. Inventories incoming accessions. Updates specimen lists. Maintains computerized museum records such as inventories and catalog files, using a computer and the Interior Collection Management System (ICMS). Monitors museum climate, downloads and graphs data loggers. Implements pest control plan. Creates content for park web pages to educate about the park museum collection.


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August 16, 2016 | Celebrity, Herrera Live, News
#GOODGIRL has finally arrived. Watch the official film starring @karliekloss by #santiagoandmauricio #GOODTOBEBAD https://t.co/LW3EA2M80T


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The best Pulse Dose Portable Oxygen Concentrator- Portable oxygen concentrators give patients the freedom of movement and peace of mind they need while getting oxygen therapy. The Inogen One G2 is a revolutionary POC with plenty of useful and efficient features that help delivering the best oxygen therapy for patients with breathing difficulties.
Patients looking for the best mobility and freedom should definitely consider the Inogen One G2 portable oxygen concentrator. Designed with a sleek frame that looks extremely stylish, patients can now forget about the frustration of having to carry around bulky portable oxygen concentrators.
Inogen One G2: The Pulse Dose Oxygen Delivery System
Pulse Dose Delivery portable oxygen concentrators release oxygen only during the inhalation process. This automatically means that the constant oxygen flow into the nostrils is not a problem, so dryness of the nose and the throat will be avoided.
The individual health needs of patients differ greatly; this is why it is recommended to talk to your physician about whether or not such a Pulse Dose Delivery System device would be useful in your case. Many patients prefer the Pulse Dose over the continuous flow devices.
How exactly does Pulse Dose technology work? At the leading edge of each inhalation the patient initiates, an exact burst of oxygen will be delivered by the POC. This oxygen burst is initiated at a high flow rate, to ensure the patient gets enough oxygen into his lungs.
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Skip to comments.Mark Levin Show,M-F,6PM-9PM,EDT,WABC AM,May 23,2013
Posted on 05/23/2013 2:56:32 PM PDT by Biggirl
The Legacy Lives On!
Marks Lost Dog & Cat Rescue Foundation
Conservatism is the antidote to tyranny precisely because its principles are the founding principles. --Mark Levin in Liberty and Tyranny
Welcome to The Levin Lounge Step in and have a virtual FRink.
Welcome all, to the most FUN LIVE THREAD on FreeRepublic.com!
You can call Marks show: 1-877-381-3811
WELCOME Fudd Fan, And Everyone!:)=^..^=
Hey, Mark is back tonight!!!!
Mark explains it ALL and boy do we NEED him!!
Levin Frinks List:
List Of Streaming Internet Stations.
Mark Levin Show streaming links list.
KPAM: click Listen Live http://www.kpam.com/
or, go here:
WABC: http://wm-eon.vitalstreamcdn.com/live_eonwmss_vitalstream_com_abc-wabcam1
WMAL: http://wm-eon.vitalstreamcdn.com/live_eonwmss_vitalstream_com_abc-wmalam1
WCBC: http://188.8.131.52:9960/listen.pls
KABC: http://www.kabc.com/article.asp?ID=649447
From the great state of Illinois: http://cities929.com/index.php
and now from Melbourne, Florida WMMB: http://www.wmmbam.com/pages/live1.html
Mark is now on live at www.sirius.com on Patriot 144 (after Hannity)!
On XM166, America Right:
A great site for many streaming talkies:
This one does all 3 hours:
New station to try. Not sure if their stream is up yet.
Call the show 1-877-381-3811
Fudd Fan and Biggirl does not guarantee any of the above links to work at any given time.:)=^..^=
WELCOME Mark Levin!:)=^..^=
He's here
he's here!
Now broadcasting from the underground command post...
Deep in the bowels of a hidden bunker...
Somewhere under the brick and steel of a nondescript building,
we have once again made contact with our leader-—
Thanks to Levinite and FReeper cleveland gop for transcription.
This ought to be good today!
It should be!
Hey all!
Hi Clint, do not forget either tonight or tomorrow night the Sam Adams beer please! THANKS! :)=^..^=
Thanks BG. Allergy shot day again.
Your welcome!
Hey Ernie!
How is my wish state treating you?
Forget BEER, not been
Better than the SLAVE State .
first comment by the queenzz - 'this BATTLE is not over'
Wonder if they removed the engine or gas tank? That's a helluva powerful truck.
Destroying foundations - -. Sad Day
They can kiss the LDS and Catholics goodbye.
they are fools if they think gays will make up the money they lost with this move
Crap. Just frigging crap.
The majority is pissed.
uh oh, i just caught the end of the host comment. was that about Savage?
Weiner is a fraud. He was calling Sean Hannity PAWN Hannity .
Despite this setback, we will look to the future. I am pleased to announce that OnMyHonor.Net along with other likeminded organizations, parents and BSA members, are announcing a coalition meeting that will take place next month in Louisville, Kentucky. There we will discuss the creation of a new character development organization for boys.
got my money ready
They just changed to oath from "morally straight" to "morally meh"...
Yes he is. And ripping Issa a new one. Why didn't Issa hold hearings before
the election, Levin asked. Thank God Levin is back.
thanks, i heard that last night.
I thought he was talking Anthony Weieener
Yes, several times on his stream.
It Took British Cops 20 Minutes To Respond To Islamist Terror Attack Because They Had To Wait For Officers With Guns To Show Up
Weiner revealed his true Colors many Years ago. That's why he lost most stations for years.He is back because he thinks people forgot. But, I haven't.
There's a lot limp Wieners going around.
The kindergarden cops had to call the real cops.
the idiot in the whitehouse was at the podium with one of his tardz speaking to throngs of acreaming leeches yelling for more free birth control, abortions and obamaphones - the tard standing next to him said 'the koch brothers paid no income taxes' - the ONLY way to know that is by an illegal action from the irs - disclosing the koch brothers' tax information
that tard was that austin goolsby freak - the one that has a bromance with hannity (their giddy schoolgirl flirting makes me hurl) - he was on hannity again last night and hannity DID NOT ASK HIM WHERE HE GOT THAT INFO
Don't ask me to defend Hannity. He pals around with Boob Beckel, Juan Williams, Tokyo Rove and Ghoulsbee just to name a few. I couldn't do it.
In '65, when I was in England for the Welsh Nat'l Jamboree as a BSA (Eagle Scout) delegate, from the '64 Valley Forge Jamboree, I don't remember the Brit Bobbies carrying sidearms, just nightsticks. But they didn't have the muzzie problem back then, either.
I don't listen to him. I listen to Dennis Miller from 3-6.
Is this regime wanting pick a civil war against its people?
They seem to be provoking mainstream and conservatives into that position. I am feeling this more and more.
That may also explain the ammo build up in what should be benign agencies.
Just had to deal with followers of EKI-thump
I listen to both of them. I couldn't take any more of the libs Sean has on. I can't listen to them.
now THAT
is speaking 'truth to power'
standing alone and speaking truth
best vote i EVER cast
I can take Dennis in small doses. Especially when he has Dana Carvey and Jon Lovitz on he's the best. My favorite talkie is still Chris Plante..
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
BBB Accredited Business since
Nicholas Yust Fine Metal Art LLCAdditional Locations
Phone: (513) 284-6737 Fax: (513) 321-3555 View Additional Phone Numbers 3602 Eastern Avenue, Cincinnati, OH 45226 http://www.nicholasyust.com View Additional Web Addresses
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This business offers original and custom contemporary abstract metal wall art and sculpture. The artwork is available at the Yust Gallery and on nicholasyust.com
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BBB Accreditation
A BBB Accredited Business since
BBB has determined that Nicholas Yust Fine Metal Art LLC meets BBB accreditation standards, which include a commitment to make a good faith effort to resolve any consumer complaints. BBB Accredited Businesses pay a fee for accreditation review/monitoring and for support of BBB services to the public.
BBB accreditation does not mean that the business' products or services have been evaluated or endorsed by BBB, or that BBB has made a determination as to the business' product quality or competency in performing services.
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Nicholas Yust Fine Metal Art LLC sells the following brand(s): nicholas yust
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Alternate Business NamesModernAbstractDecor.com Yust Gallery
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Starwood Property Trust (STWD +4.2%) following its big earnings beat. The company put another $1B to work in Q4, bringing 2012's total to $2.6B. Assets held for investment sum to $3.4B with annualized levered return of 11.7%-12.2% expected over their life. "CMBS originators appear to be in a sweet spot," says Dynex (DX) CEO Tom Akin, looking forward to Walker & Dunlop's (WD) report next week.
Starwood Property Trust (STWD +4.2%) following its big earnings beat. The company put another...
Feb 27 2013, 12:36 ET | About: Starwood Property Trust,... (STWD) | By: Stephen Alpher, SA News Editor
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Eighth European Social Science History Conference (Oral History and Life Stories Network)
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Eighth European Social Science History Conference 13 – 16 April 2010, Ghent, Belgium Oral History and Life Stories Network
Call for Papers:
Evidence and Testimony in Life Story Narratives
The Oral History and Life Stories Network has become the major regular international forum for European oral history and life story researchers. The European Social Science History Conference has been held biannually since 1996. The Oral History and Life Stories network has met at each conference since 1998, and interest in it has been steadily rising. In 2004, some seventy participants gathered at the network sessions. Both in 2006 in Amsterdam, and in 2008 in Lisbon, the network hosted seventeen sessions, making Oral History and Life Stories one of the largest and most popular networks of the European Social Science Conference.
We invite proposals for the Ghent conference on 13–16 April 2010 both for individual papers and for entire sessions. Sessions can have various formats: panels, round table discussions, presentations in other media followed by discussion.
We wish to encourage reflection on the construction of testimony in life stories, the evolution of stories over time, how to discern the truth value of eyewitness accounts, and how to approach deeply autobiographical sources. We invite contributions discussing conceptual and methodological issues related to memory, evidence, and testimony, based on oral sources and/or personal accounts.
We would welcome proposals addressing the following issues:
- Formal components of narrative and their relationship to truth-telling and truth value;
- Past silences, how to study testimonies through time;
- Theory and methodology related to the construction of testimony;
- Humor/irony as an implicit way of telling the story;
- Why oral history matters;
- Teaching oral history;
- Digitalization/archiving oral history; the rights of interviewees;
- Contrasting traditional oral history and audiovisual oral history;
- Truth in oral history: whose perspective determines the truth;
- Eyewitness narratives and transitional justice;
- Rethinking personal history through narratives, the deliberate construction of the account;
- The influence of cultural constructions of identity on the life story narrative;
- Comparing interviews over time;
- Disseminating oral history: oral history in documentaries, exhibitions and on the internet;
- The media's use of oral sources;
- Using and re-using archived oral history data
Please send your proposals to both Nanci Adler
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Albert Lichtblau (firstname.lastname@example.com). Upon submission, you must also pre-register on the conference website http://www.iisg.nl/esshc where more general conference information is available. The deadline for sending your abstract is 1 May 2009.
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The Associated Students of Woodland Community College (ASWCC) is your student government at WCC. We represent the student body to Administration and college committees, sponsor student organizations, and host informative and social activities throughout the year. We also actively participate in the Student Senate for California Community Colleges. Our mission is to connect students to our campus so that they can succeed. We stand beside you!
Contact us via email at firstname.lastname@example.com, in room 719 during office hours, via facebook, or at any meeting or event we hold.
The ASWCC is looking for the following positions:


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Find hotels & motels in Cafayate using the list below. Find cheap and discounted hotel/motel rates in or nearby Cafayate, Argentina for your personal leisure or group travel. Discover the most popular Cafayate hotel/motel rooms. Review the Cafayate hotel list below to find the perfect lodging. We also have a map of the Cafayate hotels.
With a stay at Hostal Andino in Cafayate, you'll be minutes from Salvador Figueroa Winery and El Transito Winery.
Located in Cafayate, La Casa de la Bodega is minutes from El Esteco Winery and close to Vasija Secreta Winery.
Located in Cafayate, Patios de Cafayate Wine Hotel is in a rural location, minutes from El Esteco Winery, and close to Vasija Secreta Winery.
With a stay at Grace Cafayate in Cafayate, you'll be close to Salvador Figueroa Winery and El Transito Winery.


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Italian Jacquard Turkey Kitchen Towel
- Manufacturer: Sur La Table
- Material: Cotton
- Care: Machine washable. Cotton is a natural fiber and may shrink when washed
- Dimensions: 28" x 20"
- Made in Italy exclusively for Sur La Table
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Our generously sized kitchen towel adds a touch of autumnal charm to any kitchen. Soft, absorbent cotton is perfect for drying dishes and makes wiping up...See product page for full details »
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Traveling is a great way to expand ones horizons. It introduces one to new cultures and ideas, expands ones understanding of the world, and can be extremely fun to boot.
Before I share with you're the best destinations to explore the world, remember these tips;
- When traveling internationally on a budget, consider taking flights rather than trains to your destinations. While trains are perhaps the more traditional mode of transportation for backpackers, many airlines offer discount flights that are much cheaper than train tickets. This way, you can travel to more places without adding to your budget.
- When vacationing in a foreign country, be careful what you eat. If you suffer from severe food allergies, make sure you are able to speak those food related terms in the native language of your travel destination. This helps ensure that the wait staff is clearly informed of your allergies in case of an emergency.
- It is important to do research before you pick your destination and it is incredibly important to shop around.
Okay, where to go? Here goes my list:
#1. Marrakech, Morocco
A magical place, brimming with markets, gardens, palaces, and mosques.
What it can offer? It has the best blend of history and modern adventure, with various tour options for your last day, to cater to travelers of all interest types.
#2. Siem Reap, Cambodia
Fond of ancient structures? Familiar with the temples and ruins of Angkor Wat?
I love the moment experiencing the sunrise at Siem Reap. Simply a wonderful place to visit. I'll definitely missed the action-packed adventure I had.
#3. Istanbul, Turkey
Europe and Asia meet in Istanbul. Yes, you read it correctly.
Istanbul is a place where the breathtaking ancient architecture coexists with modern restaurants and nightlife.
#4. Hanoi, Vietnam
What mesmerizes me at Hanoi? This charming place preserved the Old Quarter, monuments and colonial architecture, while making room for modern developments alongside.
Best part? You can explore the 600 temples and pagodas of this City by taxi. Woo-hoo!
#5. Prague, Czech Republic
Ahhh… The bohemian allure and fairytale features of Prague. This is a perfect destination for beach-weary vacationers who want to immerse themselves in culture.
I recommend spend time wandering the Old Town Square before heading over to gape at The Old Town Hall and Astronomical Clock.
And guess what? The historic pubs set the scene for a night of traditional tippling.
#6. London, United Kingdom
The crown jewels, Buckingham Palace, Camden Market… need I say more? There's a lot to explore, I may run out of words enumerating and describing them each. Haha!
Love fashion? Oxford Street has shopping galore.
Culture aficionados? Then don't miss the Tate Modern and the Royal Opera House.
Food junnkie? Try the cream tea at Harrod's or crispy fish from a proper chippy offers classic London flavor.
Music and book buff? Go check out the Abbey Road and the Sherlock Holmes Museum at 221B Baker Street.
Like I said, the list is endless.
Traveling is one of the greatest experiences one can have in life. The ability to meet new people, explore new places, and learn about new cultures is unprecedented.
So, TRAVEL. <3
You'll never regret it.


text:
Lizzie Kimbrell Page, 94, died Sunday, Dec. 17, 2000.
A native of Habersham County, Mrs. Page was a daughter of the late Thomas James Kimbrell and Cordelia Carpenter Kimbrell and was the widow of Clark Page. She was preceded in death by a daughter, Emma Brumbaugh. She was a homemaker and was a member of Eastern Star and Welcome Home Baptist Church.
Services will be at 2 p.m. today at Whitfield Funeral Home, South Chapel, Baldwin, with the Revs. Sanford Kimbrell and Larry Ryals officiating. Burial will be in Welcome Home Baptist Church cemetery with the Rev. Ray Turpin officiating.
Survivors include a daughter, Lucille Rodacker, Cornelia; a son, Jesse Page, Mount Airy; a sister, Lessie James, Demorest; 10 grandchildren; 14 great-grandchildren; and four great-great-grandchildren.
Athens Daily News, Tuesday, Dec. 19, 2000
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TV & Radio
Tania Zaetta's three-page nude magazine spread last week was barely noticed
- From: The Sunday Telegraph
- April 30, 2012
of 2
- Tania Zaetta poses nude for New Idea
- Three-page spread doesn't make cover line
- Says she did Apprentice to show business skills
SHE'S gone from Who Dares Wins to Who Bares Grins, but has reality star Tania Zaetta won many new fans in her nude spread
Oh, you didn't know that Zaetta, 42, was splattered across three pages of the tabloid New Idea magazine in her birthday suit? That's the problem - not many other people noticed it, either.
And unfortunately the magazine's editor, Kim Wilson, didn't feel moved enough to put Zaetta on the cover for her brave shoot (Angelina Jolie nabbed that one with her marriage news).
The reality star even failed to rate a cover line, although chef Manu Feildel's favourite dessert (pain perdu with vanilla ice cream and figs) was given a mention and a postcard-sized photo on New Idea's April 30 cover.
It's as if Zaetta decided to stroll naked through the city just at the time everyone was having a siesta.
At least Wilson mentioned Zaetta at the end of her editor's letter on the magazine's inside cover.
But why not promote the story?
According to a Pacific Magazines spokesman, Wilson was in a conference last Friday and could not be contacted, not even by email, so we shall probably never know.
However, it at least served to remind us that Zaetta is still very attractive, especially after she was pitted against the much younger and more sporty Lauryn Eagle in Celebrity Apprentice.
In the piece, which features two full nude shots of , as well as others when she is clad only in denim shorts, the recently fired member of the latest Celebrity Apprentice series puts the record straight on the scandals that have plagued her.
For a start, Zaetta reveals that she has "TV shows on air around the world" but decided to sign on to Apprentice to showcase her business skills.
She also puts paid to the story that David Hasselhoff failed to remember her from her role on Baywatch.
"He did remember me when he came in and even remembered where we had shot a couple of scenes."
Zaetta goes on to discuss her controversial charity Peace For The Children, being arrested for being a public nuisance on the Gold Coast and insisting that police didn't proceed with any charges.
It's a very interesting interview, particularly in light of her exit from the show last Thursday, when she was unanimously voted off by her team and accused by Patti Newton of being an "actress".
The only thing that is certain is that we are certain to hear about her for some time to come.
Have your say
- Skip to:
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Add your comment on this story
Comments on this story
Andy of Perth Posted at 10:48 AM April 30, 2012
What a beautiful woman. Good on her.
Tango Posted at 10:46 AM April 30, 2012
She has some body, but she's still a nobody.
Matt of Australia Posted at 10:45 AM April 30, 2012
Who is Tania Zaetta?


text:
Posted on August 2, 2013 in Miscellaneous
The finals of the TW Friday Doubles League pitted the aptly-named Team Air Cooled, who caught fire in the playoffs after some tough losses during the regular season, against Team Johnson and O'Leary, looking to complete the whole season unbeaten. Could Chris and Granville continue their hot streak, or would Andy and Spencer have enough left in the tank for one more hard fought victory?
In their previous matches against each other during the regular season, Chris and Granville took early leads in the pro set but were unable to close them out, losing both matches closely. In the finals, it was no different. Granville came out playing exceptionally, working the angles of the court beautifully and providing a daunting presence around the net while Chris backed him up with his usual guile and speed. After breaking Andy in the first game of the match, they jumped out to an early 3-1 lead, putting the pressure on Andy to hold in the fifth game to keep the match within reach.
Andy and Spencer hung tough and began playing a bit more aggressive, taking away the net from the charging Team Air Cooled. After a couple close games went their way, they evened the match and seemed to gain back a bit of the momentum.
The next few games were close as well, as each team took turns imposing their aggressive play on the other. It just so happened that Team Johnson and O'Leary were able to pull out each one of them. Frustration set in, allowing Andy and Spencer to win the last 7 games of the match, taking the TW Friday Doubles League championship with an 8-3 victory.
"We stuck to the old 80/20 rule of business," Spencer offered in a quick-witted pearl of wisdom. "80% of the time, I am involved in 20% of the points. It was a time tested recipe that worked well for us, culminating in the ultimate goal…The FDL Championship." "And yes," he added, "I'll be going to Disneyland."
Thanks for tuning in this season all along the way! We had a blast with it here at the Warehouse, and we hope you guys enjoyed the reports and some of the highlights from our match play.
Thanks for reading!
Tennis Warehouse FDL Championship Match
Team Johnson & O'Leary (1) def. Team Air Cooled (3), 8-3
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Our Last Booking Was Taken For Room 12 at 9:48 pm on Thursday 29th September 2016.
© Wheeldale Whitby Limited 2012 - 2015
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Proprietors P. D. and R. L. Coleman
VAT No.: 828403431
Website and Bespoke Hotel Management Software by Jack Barber LimitedTerms and Conditions • Park and Ride Whitby


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Tigers general manager Dave Dombrowski stated the team was likely done signing big free agents, but would still be looking to improve the club.
It appears as if they've found their answer to their left field question, reportedly signing Rajai Davis to a two-year deal.
The hypothesis among many would be that Davis would work in a platoon with last year's left fielder, Andy Dirks, who struggled after a strong 2012 season.
Davis hit .260 with a .687 OPS in 2013 for the Blue Jays, swiping 45 bases. For his career, he's hit well against left-handers, with a .779 OPS.


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Artist: Don Williams
Album: Country Boy
I'm back on the road
Sometimes I don't know
It's hard to make good sense of it all
When I have to roam
My mind's back at home
Thinking of you there all alone
But we're doing well
Somehow I can tell
I really don't know
It's something I feel
'Cause we've been making it strong
Each day right along
Though we both hate being alone
It's gotta be magic
We're still in tune
There's good loving
Midnight or noon
It's gotta be magic
I know it's true
'Cause it's still working
For me and you.
We keep saying goodbye
We keep on wondering why
Though we both know it just has to be
Oh, but honey the road
Can get to be such a load
You're all that helps me make it I know
It's gotta be magic
We're still in tune
There's good loving
Midnight or noon
It's gotta be magic
I know it's true
'Cause it's still working
For me and you...
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