text:
Top Definition
the deliberate intention of punching a guy in the testicles.
"For some odd reason, I have the urge of sacking someone."
by DerangedShadow November 18, 2007
Trending Now
Can you define these popular missing words?
when a male takes out his testicles and just lets them hang there when he walks. Sorta like sagging.
Person 1: Dude stop sacking my grandma is here.
by pielover97 December 13, 2010
It is when you take a photo of yours or someone else scrotum near a person's face while they sleep.
Shane passed out early so we took a picture of me sacking him.
by AmbushJake March 31, 2009
Somebody with huge balls. Its play on the nickname for the Sacramento Kings basketball team.
Josh's balls are so big that they're starting to wear a hole in the crotch of his jeans. He's more of a sac king than Spud Webb.
by ShaneWood January 12, 2012
When someone slightly lies, but doesn't exaggerate the truth enough so that it is actually impressive. Most commonly used to increase ones self esteem, but not exaggerating so much that it is unbelievable.
CJ: You seem smart, what math course are you in?
Ian: Calculus AB
* actually in honors calculus *
Jason: First, why would lying about his math course make him look cooler? Second, why wouldn't he just say he was in Calculus BC if he wanted to look impressive?
CJ: I guess he was just sacking
Ian: Calculus AB
* actually in honors calculus *
Jason: First, why would lying about his math course make him look cooler? Second, why wouldn't he just say he was in Calculus BC if he wanted to look impressive?
CJ: I guess he was just sacking
by Bro Code Vocab July 12, 2015
A drinking game played between men in which the object of the game is to take out your testicles, and have the opponent look at them. Doing so will mean the opponent owes u either a beer to chug, or a shot of hard liquor. Once sack wars are declared, then sacking (the act of pulling out one's sack) is fair game at any time for the rest of your life, until a player surrenders due to emotional trauma for seeing so much ballsack. The drinks owed will tally, and the sacker (the one who sacks you) can make the sackee (the one who sees sack) drink them at any time. WARNING: some will take this game way too far when introduced, even sacking females, and may cause you to surrender so beware. Last but not least, there is a special type of sacking called the goat, in which the sacker tucks his balls between his ass cheeks, and bends over so you see it from behind. This rare maneuver is worth two drinks.
sacking is for all genders, bitch
by sackmaster3000 June 23, 2011
either your on someone or you wanna stick someone its the way you use it
"damnn girl you sacking that nigga balls"
"dawg i feel like sacking that nigga."
"dawg i feel like sacking that nigga."
by evaaa January 18, 2008


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Bakers & Chefs Beef Franks (80 ct.)
by Bakers & Chefs | Item #: 256658 | Model #: 70588 |
Top Rated
Non-members pay 10% surchargeJoin now!
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^Free shipping (if noted above) is available within the continental U.S. only. Offer excludes Alaska and Hawaii. Shipping to AK or HI adds a location surcharge to the regular rate. Delivery estimates, taxes, and fees are based on ZIP Code. Club Pickup orders are based on your club's current price and item availability on the day of payment.
About this item
- 10 pound box with a total of 80 franks
- Fully cooked
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Bakers & Chefs restaurant-quality products are designed to meet the high demands of the commercial foodservice business. Every product is independently tested and selected to ensure the performance you expect, for an everyday low price. The result is a quality item backed by our commitment to your satisfaction.
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subset: commoncrawl


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Garmin - dēzl 770LMTHD 7" GPS with Built-In Bluetooth, Lifetime Map Updates and Lifetime Traffic Updates - Black
- Model: 010-01343-00
Preloaded base maps of the U.S., Canada, Mexico, Puerto Rico, the U.S. Virgin Islands, the Cayman Islands and the Bahamas; 7" touch screen
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Teacher and employee engagement has been found to be a crucial component in the success of a school district, positively impacting student achievement, improving employee retention and reducing turnover.
Education leaders are rallying to transform America's high schools to better prepare students for their future of meeting the economic need of high-skill, high-demand jobs right out of school college. Career readiness programs are igniting a passion for learning in students and providing them opportunities for training and certifications, while keeping them on track to graduate.
References to vocabulary development are interwoven throughout the College and Career Readiness Standards in what might at first seem like jigsaw puzzle pieces. However, when we learn how to put the pieces together, they reveal a coherent picture. The goal is to provide students with the word knowledge and vocabulary strategies they need to succeed as readers, writers, speakers, listeners, and thinkers across many domains to successfully access text, communicate across the curriculum, and acquire the content knowledge needed for college and careers.
The changing landscape of K12 education in the 21st century has transformed the role of the school principal. Today the expanded leadership responsibilities of principals have made them more crucial than ever to the success of a school district.
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In the Charlotte-Mecklenberg Schools, administrators have developed a leadership pipeline and succession plan that are helping the eighteenth-largest school system in the country achieve long-term success.
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Police: 5-year-old dies after ATV crash Saturday in Shaftsbury
SHAFTSBURY Police are investigating the death of a 5-year-old boy who died after an all-terrain vehicle crash on Hidden Valley Road in Shaftsbury on Saturday.
A press release from the Vermont State Police said Benjamin Prouty, 5, of Shaftsbury, was pronounced dead at the Southwestern Vermont Medical Center in Bennington.
After the initial investigation, police said the incident does not appear suspicious.
Detective Sgt. Sam Capogrossi of the Vermont State Police said police were called around 7 p.m. Saturday because of a call made to a 911 operator that a child was not breathing as a result of an ATV crash at his home on Hidden Valley Road in Shaftsbury.
Troopers from the Shaftsbury barracks of the Vermont State Police went to the home immediately and assisted in performing cardiopulmonary resuscitation until an Arlington Rescue Squad ambulance arrived to take the boy to the hospital.
Detectives with the Vermont State Police Bureau of Criminal Investigation initiated an investigation of the death. The childs body was taken to the office of the Chief Medical Examiner for a postmortem examination.
Capogrossi said no further information will be available pending the results of the autopsy and completion of the investigation.
Vermont state law allows riders younger than 12 to use ATVs if they are on land owned by their parents.MORE IN This Just InMORRISVILLE Overtime magic from Chloe Schiff and Maralina Moore gave the Solons a huge... Full StoryBARRE TOWN The Raiders proved that records mean little with Fridays victory over their... Full StoryWILLIAMSTOWN Life just keeps getting better for the undefeated Blue Devils. Full Story
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Real Housewives of Atlanta's Nene Leakes was chatting up New York City star Ramona Singer over white wine – Pinot Grigio for Singer; and Riesling for Leakes – at Asia de Cuba in N.Y.C. Singer was showing off her jewelry line, but the ladies mostly gossiped about their own shows – and the other Housewives, including Danielle Staub.
Was she trying to impress her new guy? Vienna Girardi, getting her hair coiffed and styled at Patrice Bisiot Salon at the Regent Beverly Wilshire Hotel in L.A. And when she left, the reality star was glammed-up, sporting a much curlier do.
Beyoncé and Jay-Z dropped anchor in Saint-Tropez during their vacation at sea. The couple headed ashore to Club 55, where they lunched on a seafood platter, raw vegetables and champagne. After, the singer was spotted jet-skiing and catching some waves.
Blake Lively dropped $320 on a pair of Tiffany & Co shades while shopping at the Sunglass Hut's Fifth Avenue flagship store in N.Y.C. The Gossip Girl star settled on a pair of gold aviator frames.
Miami Heat's Chris Bosh, chilling out and chowing down on lobster peanut butter & jelly at The Forge in Miami. The NBA star was partying at Ocean Drive magazine's "Welcome to Miami" reception, and was greeted by a crowd of over 300.
By JENNIFER GARCIA, MELISSA LIEBLING-GOLDBERG, LINDA MARX, LESLEY MESSER and PETER MIKELBANK
Caught in the Act!
Frank Micelotta; Neilson Barnard/Getty(2)


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Rent Red or Blue, I Like You 1st edition today, or search our site for other textbooks by Sarah Albee. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Dalmatian Press.
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Associate Professor
"I strive to provide highly professional, caring and compassionate care, and look forward to the opportunity to serve you."
(262) 532-5700
(414) 955-2020
(262) 798-7200
(414) 955-1050
925 North 87th StreetMilwaukee WI, 53226Phone:(414) 955-2020Fax:(414) 955-6300Get Directions
2315 E. Moreland Blvd.Waukesha WI, 53186Phone:(262) 532-5700Get Directions
4805 S. Moorland RoadNew Berlin WI, 53151Phone:(262) 798-7200Get Directions
1155 N. Mayfair RoadWauwatosa WI, 53226Phone:(414) 955-1050Get Directions
Dr. Gregory J. Griepentrog is a fellowship-trained, board-certified ophthalmologist who specializes in ophthalmic facial surgery (also known as oculoplastic and orbital surgery). This area includes medically necessary eyelid surgery, facial cosmetic surgery, thyroid eye disease and orbital and lacrimal (tear duct) disease. Dr. Griepentrog is a Milwaukee native and completed his medical degree at the University of Wisconsin-Madison and ophthalmology residency at the Mayo Clinic in Rochester, Minnesota. He served as a faculty member at the Mayo Clinic before returning to the University of Wisconsin-Madison to complete a two-year fellowship sponsored by the American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) and the American Academy of Cosmetic Surgery (AACS).


text:
Fixed PriceBudget: $50
Start DateMarch 6, 2013
I have 1,000 bulletin board emails that I need the data extracting from and collating into a spreadsheet.
These are job listing emails. Typically each email has 18 to 20 jobs listed.
1) I need duplicate listings removed.
2) For each job listing I need the date of the email, title of the job, region it is for and whether it is paid or unpaid all extracted into separate columns.
3) The job titles then need to be tagged into a reduced taxonomy.
About the Client
United Kingdom
London 09:59 PM
Jobs Posted
34% Hire Rate, 1 Open Job
Total Spent
1 Hire, 0 Active


text:
Pokemon X
This is a split board - You can return to the Split List for other boards.
Rayquaza_is_Z 3 years ago#11
Oh wait, that's a different user..lol
http://i.imgur.com/EOXWVm0.jpg Do you wanna be cool?
Join the Reservoir Dragons! Support Draceon for 2013!
Zacks_Fair 3 years ago#12
WobbuffetGod posted...
PINK =/= Fairy
Official Hua Po of SMT4 board
3DS FC 3566-1544-7318 PM me if you add me!
tyranitartyrany 3 years ago#13
I'd love a grass/fairy Lilligant. Instantly going on my team if it gets fairy type. Quiver Dance/Petal Dance and own tempo won a lot of battles during white 2 for me. Throw in a strong special fairy move and sleep powder for good measure and I'm drooling....
But I have to wonder why pokemon like misdreavus and luvdisc are on this list. Lilligant doesn't really make much sense either...
Currently playing: Mass Effect 2, Mario & Luigi: Dream Team, Pokemon: SoulSilver
Just finished: The Last of Us, Kingdom Hearts 3D
Skitty was in the demo, so he's out.
If they're retconning dualtypes, I consider Celebi a possibility. Frankly, I think Celebi looks more Fairy-like than any Pokemon save Flabebe and maybe the Sinnoh trio.
Creator of Jay's Journey (see quote!)
"It's not ten years old! Therefore, it sucks!" - Nostalgia whores everywhere
Donniedonz posted...
Hejiru posted...Donniedonz posted...Nearly Guaranteed
So then put them under "likely in my opinion" or something. The only ones "nearly guaranteed" are Clefairy and Snubbull.
"The difference between fiction and reality is that fiction has to make sense." -Tom Clancy
pyrotempestwing 3 years ago#16
Okay, in order:
Nearly Guaranteed
- Clefairy line: Definitely
- Chansey line: Probably
- Togepi line: Doubt it due to dual-types*
- Snubbull line: Probably not, but they should
- Skitty line: I can see that happening
- Luvdisc: Um, what?
- Uxie, Mesprit, Azelf: Possibly, but not likely
- Audino: Yep.
- Petilil line: Dual-types already*
- Bellossom: Maybe
- Lickitung line: Doubt it
- Dunsparce: Doubt it 2: Electric Boogaloo
- Chimecho line: Possible
- Finneon line: Dual-type*
- Gothita line: Doubt it, though possible
- Sunkern line: Meh, don't really care 'bout thissun
- Whismur line: Possibly
- Castform: No
- Gorebyss: No
- Manaphy (not Phione): Both or neither, not just one
- Munna line: Maybe
- Alomomola: No.
Slim chance
- Misdreavus line: Maybe
- Stantler: No.
- Altaria (Dragon/Fairy): Dual-typed*
*Dual-typed Pokémon have never been retyped, with the exception of Rotom's formes due to limitations in the 4th Gen (Read: DS) game. So, not likely. Possible, but infinitesimal at best.
FC's: B1: Lexi 2365-9525-1918; B2: Misaki 4213-1809-7119 3DS FC: Thomas 5069-4431-9392
Yeah, I'm a crossplayer. Deal with it.
Lord_Vishana 3 years ago#17
No Banette?
Cuteness Overload! http://i.imgur.com/gw03gl7.png World's Biggest Kenichi Ebina Fan 3DS FC: 3394-3716-0128 Vita PSN: Queen_Sialeeds
WobbuffetGod 3 years ago#18
pyrotempestwing posted...
- Petilil line: Dual-types already*
While I am in 100% agreement that dual types won't be retyped, and that these guys will not... neither of them are actually dual types.
pyrotempestwing 3 years ago#19
WobbuffetGod posted...
pyrotempestwing posted...- Petilil line: Dual-types already*
Huh, coulda sworn Lilligant was Grass/Poison and Lumineon was Water/Flying. Whoops. That one's on me then. My bad.
- Petilil line: Possible, but unlikely
- Finneon line: No
FC's: B1: Lexi 2365-9525-1918; B2: Misaki 4213-1809-7119 3DS FC: Thomas 5069-4431-9392
Yeah, I'm a crossplayer. Deal with it.
i think Jirachi would fit Fairy type nicely
PSN: Upyers 3DS FC: 3411-0787-8191 Black 2 FC: 0391 1086 2871
kingblink.com Kingdom Hearts 1.5 & Pokemon Y
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Product Information
Product Information
Grace Digital Audio MONDO Internet Radio Red GDI IRC6000R
The Grace Mondo Wi-Fi Music Player is Grace Digital's latest Internet radio with a class leading 3.5 in. Color display. Enjoy vivid colorful station or album art while listening to your tunes and effortlessly navigate through the icon based menu system. Listen to over 18,000 free radio stations and endless on-demand content from around the corner to around the world, including NPR, BBC, iHeartRadio, CBS and more. In addition, get access to premium free music services such as Pandora, iHeartRadio and Dar.fm or premium pay services such as SiriusXM Internet Radio and Live365 VIP.
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text:
Project Cauã V0.5
Project Cauã V0.5
Neither time nor politics can stay the progress of Project Cauã.
What would you do if you came up with an idea that could create more than 4 million new hightech jobs, reduce the amount of electricity used by computers, make systems easier to use, reduce the amount of waste thrown into landfills, supply gratis wireless networking for people, and create a huge grid of free or "almost free" supercomputing for university and business projects needing huge amounts of CPU power, doing all of this with private sector money in a way that would pay for itself and be self-sustaining?
At this time of massive unemployment and governments straining to be solvent, would you keep this idea to yourself in hopes of making money, or would you give it away?
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Nextcloud Announces Raspberry Pi-Powered Home Cloud Box
Innovative system adds a hard drive and Ubuntu Core to the RPi for an IoT hub.
Linus Torvalds Confirms the Date of the First Linux Release
Linux is two weeks younger than we thought!
End of OpenOffice?
The Apache Software Foundation considers retiring OpenOffice
Adobe Gives New Life to NPAPI Plugin for Linux
Adobe won't kill the plugin in 2017
LinuxCon North America Convenes in Toronto, Canada
Linux Foundation's big event celebrates the 25th anniversary of Linux
Linux Turns 25
Linux has evolved from "won't be a professional" project to one of the most professional software projects in the history of computers.
Mirantis Joins Hands with SUSE To Offer RHEL Support; Red Hat Not Happy
Competitors get in the game with RHEL without Red Hat
Linux on Windows 10 Poses a Security Risk
Security researchers have already notified Microsoft; some fixes are available
Mirantis to Refactor OpenStack Fuel for Kubernetes
The company is collaborating with Google and Intel to use Kubernetes as an engine for Fuel
Canonical Joins Document Foundation Advisory Board
The upcoming release of LibreOffice will be available as a snap package


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7 reviews | 4.3 out of 5
I can't say it enough: I LOVE this foundation. It is the BEST mineral makeup - or just about any makeup - that I've tried in years. Since my mid-30s I've searched for a match to my skin tone, but also wished I had a foundation I could wear outside in the daytime and not feel like I'm wearing a mask ready to melt off. Long ago I tried the infomercial brand of mineral makeup and it worked great, but as a working wife and mother of 3, I just couldn't afford the monthly obligations of kit orders expected of customers. I finally found its competition in this product, even better! I bought the medium Physicians Formula airbrush kit that also came with blush and bronzer. Fortunately it was on sale, which made the deal that much sweeter! I'm not scared to take photos anymore, because when the pics come out I don't have a completely different skin color on my face. When I'm outside I feel a LOT better too, knowing I'm not wearing a whole bunch of liquid and powder foundations trying to blend my uneven skin tone. I suggest this make up for anyone wanting an "airbrushed" look to their skin, no matter what your age. It gives your skin a very pretty, natural, even tone. I will definitely start using more of this product line now that I'm confident it works!
Not cakey
I am in my 40s with oily, acne prone, sensitive skin. I have tried cheap to very expensive brands and never been happy with the results. The first day I wore this my boss complimented me on how good my skin looked. Usually, make up wears off by noon because of my oily skin, but this lasts all day. It is enough coverage to cover my blemishes but not look heavy and has not caused any break outs. I was not happy with the brush included so used a powder puff. The coverage really is an airbrushed, satin look. Very pleased!
Its great! A friend bring me this. I tried it and it works. First I love this brand because they doesnt tested on animals. Second when i try it on my skin looks flawless, it doesnt let my skin looks dry or oily even I have this type of skin. Someone told me that my skin looks better since I use this product. I RECOMMEND IT 100%
I am Indian and have yellow/ brown tones, I guess it is considered olive tone. In the store it looked like it will match but did not. Store lights are never good to choose a foundation color by. Wish there were mini tester per individuals to take home and try before buying. Anyway, I love this brand but not the fact it doesn't have wide variety in foundation color :(
Works as well as any of the major brands.
This is my absolute favorite compact powder ever! I just think it's a little over-priced. I hope you never stop carrying it!


text:
Emperador Hotel Buenos Aires - Buenos Aires
This hotel offers a health club, a restaurant and dry cleaning/laundry. Relax in the indoor pool during your stay. Guests wishing to enjoy a drink will surely want to visit one of the 2 bars/lounges. In addition to the on-site spa, a fitness center and a sauna are among the leisure facilities on offer.
Multilingual staff are available at the front desk 24 hours-a-day and can provide tour/ticket assistance, express check-in and express check-out. WiFi and high-speed (wired) Internet access is available.
Emperador Hotel Buenos Aires - Buenos Aires
Hotel Info: 1-877-214-4288from $162
- Deluxe Room, 1 Queen Bed
- Deluxe Room, 2 Queen Beds
- Junior Suite
- Suite, 1 King Bed, Corner
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 265 rooms
- This hotel is arranged over 21 floors
- Check-in time 3 PM-midnight
- Check-out time is noon
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum guest age is 18
- Minimum check-in age is 18
- Minimum Spring Break check-in age is 18
Travelling with others
- One child (7 years old and younger) stays free when occupying the parent or guardian's room, using existing bedding
- Babysitting/childcare *
- No pets or service animals allowed
- WiFi and wired Internet access in public areas *
- WiFi and wired Internet access in rooms *
- Self parking *
In the hotel
- Buffet breakfast daily (surcharge)
- 2 bars/lounges
- Restaurant
- Coffee shop/café
- 24-hour room service
- Indoor pool
- Fitness facilities
- Full-service spa
- Spa treatment room(s)
- Health club
- Steam room
- Sauna
- 24-hour business center
- Meeting rooms 12
- Conference space size (feet) - 10764
- Conference space size (meters) - 1000
- Conference center
- Computer station
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Limo or Town Car service available
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Wedding services
- Multilingual staff
- Porter/bellhop
- Number of buildings/towers - 1
- Year Built 2000
- Elevator/lift
- Safe-deposit box at front desk
- Designated smoking areas
- Garden
- Terrace
- Television in common areas
- Accessible bathroom
- In-room accessibility
- Roll-in shower
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Minibar
- Coffee/tea maker
- Hypo-allergenic bedding available
- Pillow menu
- Blackout drapes/curtains
- Soundproofed rooms
- Turndown service
- In-room massage available
- Private bathroom
- Deep soaking bathtub
- Bidet
- Free toiletries
- Hair dryer
- 21-inch LCD TV
- Premium TV channels
- Desk
- WiFi (surcharge)
- Phone
- Daily housekeeping
- In-room safe (laptop compatible)
Special features
The onsite spa has massage/treatment rooms.
DiningMaximus - Onsite restaurant.
Emperador Hotel Buenos Aires - Buenos Aires's small print
Also known as
- Buenos Aires Emperador Hotel
- Emperador Buenos Aires
- Emperador Hotel
- Emperador Hotel Buenos Aires
Parking height restrictions apply.
Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation.
Optional extras
Self parking costs ARS 330 per night
Rollaway beds are available for ARS 720 per night
Breakfast costs between ARS 260 and ARS 400 per person (approximately)
Babysitting/childcare is available for an extra charge
WiFi is available in guestrooms for ARS 115 per day (rates may vary)
WiFi is available in public areas for ARS 180 per day (rates may vary)
High-speed Internet access (wired) is available in guestrooms for ARS 115 per day (rates may vary)
High-speed Internet access (wired) is available in public areas for ARS 180 per day (rates may vary)
Dial-up Internet access is available in guestrooms for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
A significant loss to the sewing and craft community.
------"We don't see things as they are, we see them as we are." Anais Nin
"Attitude is the difference between an adventure and an ordeal." unknown
January 2009 to January 2010 81 yards out and 71yards in January 2010 to the present 106.7 yards out and 146.5 yards in. January 2011 to the present: 47 yards out and 69 yards in.
------"Play the cards you are dealt, but choose who is sitting at the table"..AARP magazine
SEE MY ETSY SHOP HERE: http://www.etsy.com/shop/AuntMaymesAttic
My blog: http://auntmaymesattic.wordpress.com/
------"Be kind whenever possible. It is always possible."
--Dalai Lama
I have sewing machines
------ Remembering my most loved BFF (Best Furry Family, a very close friend, family)...The Baby my kins, my Abigail ..11/2/03 - 3/7/16
She's my Baby & I'll love her if I want to, love her if I want to.... you would love her too she's the Baby ... the kins ...sung ..just one of her songs..
I miss you an awful lot my Baby ...Ab-i-gail she would come running when I would say her name like that...
Lord please take care of my much loved kitty. +
Thank you Lord for loaning me the much loved Babykins. +
------"TOL machines = Too (much) Operator Learning"--poorpigling, January, 2016
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mobile site
Mobile Responsive Sites Boost Search Rankings for SMBs
While most SMBs know that mobile responsive sites boost Google rankings, many don't know that pain points in mobile search could be costing both clicks and rank.
How Top Restaurants Serve Up and Stack Up in Mobile SEO
The Search Agency (TSA) analyzed how top restaurants and catering businesses fared against its mobile SEO criteria in its latest "mobile experience scorecard" report.
Google Informs Webmasters of Faulty Redirects for Mobile Users
Reports this week show webmasters are starting to see notifications from Google when faulty redirects are detected.
Google Updates PageSpeed Insights Tools With User Experience Rules
Google added user experience rules to its PageSpeed Insights tool, which helps site owners create a better mobile experience for website visitors. The tool was updated to a mobile-friendly design and documents were translated into more languages.
Many Web-Only Retailers Fail to Offer Optimized Mobile Experiences [Study]
The Search Agency today released a new mobile scorecard report, which looked at the Top 100 Web-only retail sites to see how well they fared against key elements in a mobile user's experience. The average score was about 2.8 out of 5.
Google Tests Restaurant Menus in "Card" Results
The recent discovery that Google is testing restaurant menus in its "card" results sparked discussion about where Google likes to get its data and how websites can continue to help the search engine better understand their information.
B2B Search: It's Time To Go Mobile
Your customers are using mobile devices. If you're paying to send customers to your site using PPC, a poor mobile experience will cost you. Now is the time to get your site ready for mobile prime time and harness the true power of mobile PPC.
Google's Matt Cutts: Responsive Design Won't Hurt Your SEO
There are fewer SEO drawbacks when using responsive design versus a lightweight mobile version, but a mobile site can work just as well as responsive design, as long as you avoid dividing your PageRank and duplicate content issues.
Fortune 100 Companies Not Measuring Up in Mobile [Study]
The Search Agency is keeping score on Fortune 100 companies and their mobile experience. What they found were less-than-perfect scores among the biggest brands in the United States. Coca-Cola and FedEx received the highest scores.
7 Critical Web Redesign Considerations You Can't Overlook
Planning a website redesign can be an extremely exciting process. While having a great looking website is awesome, technical SEO, content, and functionality can't be an afterthought. Here are some key considerations to avoid a redesign disaster.


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Alex Salmond was yesterday forced to ditch the oil revenue forecasts that underpinned his blueprint for independence and admit that a separate Scotland could find itself deeper in the red than the rest of the UK.
The embarrassing concessions are contained in a report published by the SNP government on the same day the Treasury released its own analysis of the economic implications of independence. The timing led to claims that the first minister was attempting to bury bad news.
The Scottish government's paper contains oil revenue forecasts that the administration has been under pressure to publish for months. They
At the end of a long day of blast and counter-blast in the referendum campaign, Alex Salmond claimed that he had blown the Treasury's case to pieces while setting out the positive case for an economically successful, independent Scotland.
The claim looks scarcely credible. The major foundation of the Yes campaign has been that thanks to gaining control of oil revenues, an independent Scotland would have a healthier balance of spending and taxes than the UK. But the balance sheet that he produced yesterday says that is unlikely.
If Scotland takes a population share of UK debt and continues to pay its servicing costs, which John Swinney, the finance secretary, has previously said is "fair and reasonable", then the Scottish government says that Scotland will have a deficit of 2.8 per cent of GDP in 2016-17, the planned first year of independence. That, however, will be above the UK's deficit of 2.4 per cent of GDP projected by the Office of Budget Responsibility (OBR). That also depends on North Sea oil revenues being £6.9 billion, which is way above the OBR's estimate of £2.9 billion.
There are many reasons to be sceptical of the Scottish government's forecast, not least its own proven record of being grossly over-optimistic on oil revenues.
This week The Times showed that for the year just past oil revenues were likely to be about £4.2 billion, way below the Scottish government's forecast last May that they would be between £7.1 billion and £8.3 billion. Even The Times's forecast may turn out to be on the high side as published Scottish government statistics put oil receipts at £2.4 billion for the first nine months of 2013-14.
Mr Salmond's claim for victory was based on the fact that two academic experts on whom the Treasury based its calculation of £2.7 billion for the institutional set-up costs for independence had disowned the number. Yet Mr Salmond and Mr Swinney evaded answering questions of what the costs would be of building a new tax and welfare system and adding all the other institutions that an independent Scotland would need.
Mr Salmond's suggestion that the set-up costs might be £250 million should be set in the context of the fact that even the relatively small task of moving Scottish Natural Heritage's headquarters from Edinburgh to Inverness in 2004 cost £21 million (against an original estimate of £12 million).
The omission of any calculation of what the price might be of creating a Scottish diplomatic service, armed forces, tax collection and welfare payment services, and many other functions now carried out by the British government was not just a glaring omission, but also symbolic of the entire thrust of the Scottish government's publication.
It assumed that there are no downsides to independence, only upsides. Missing, for example, was any estimate of what Scotland might need to borrow on its own account after independence.
If it wants to invest in infrastructure at the rate it thinks is needed, pay for new buildings to house the staff replicating services now provided by the UK, and deal with financing shortfalls caused by uneven tax revenue flows, an independent Scotland will need to borrow and pay interest, every non-aligned analyst has concluded, at higher rates than does the UK. How much will that cost?
Far from yesterday being the winning goal for the Yes campaign, it may turn out to be an own goal.


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I have been participating in triathlons for 12 years but have been competing at an international level for the past 2 years now. Anyone that knows me knows that my two main passions amongst many are my family and competing in any race that challenges me. I am developing into a world-class athlete with extreme commitment and passion in a sport that is my real love.
My first experience in triathlon was crossing the finish line at Ironman Canada with my Mom and my 2 brothers when I was 12 years old. I remember running down the finisher shoot with the big lights and hearing the words repeated over and over to the finishers YOU ARE AN IRONMAN. That moment changed me and I knew I was made for this sport.


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'Humble yourselves and He will lift you'
Dr. David Hankins stops in Crowley
Thursday as part of his statewide 'wave'
CROWLEY - "They used to say that any preacher who wasn't hoarse on Monday wasn't doing his job," said Dr. David Hankins of the Louisiana Baptist Convention in Alexandria while standing on the steps of the Acadia Parish Courthouse. "Well, I'm used to using a microphone so I'm going to have to ask you to move a little closer so you can all hear me...or at least those of you who aren't Baptist can step aside so the Baptist's can come forward."
Those gathered for the Prayer Rally, Baptist or not, laughed heartily.
Dr. Hankins is currently traveling around the state - all 64 parishes - to hold his Prayer Rallies. Acadia Parish was the 33rd stop on his two-month tour. He also paid visits to Lafayette and St. Martin parishes on Thursday.
"Do all of you know about the 'wave' that the crowd does during football games," he said. "That's exactly what I'm trying to do is to get a wave of prayer across the state."
Dr. Hankins current tour was timed so that it would end on April 29, the bicentennial of Louisiana, on the steps of the state capitol in Baton Rouge. His prayers were for 'all public officials from the President of the United States to the city councilmen, Sheriff's and local police departments.'
"I would also like to offer prayers to those souls who are hurting," he added.
Dr. Hankins said that he often hears from people who complain that they often pray but their prayers aren't answered.
"I tell them that they may be praying with the wrong purpose,"he said. "The purpose of prayer isn't for personal rewards but to glorify God. When your purpose is to advance the kingdom of God then you can pray boldly."
"Humble yourselves and He will lift you up."
Several local dignitaries were on hand for the rally including Mayor Greg Jones, Crowley City Council members Kitty Valdetero, Bryan Borill, Jeff Dore and Mary Melancon, Crowley Chief of Police K.P. Gibson, Major Keith Latiola with the Acadia Parish Sheriff's Department and Ann Mier with the Acadia Parish Public Library.
Following Dr. Hankins, Rev. Alan Knuckles told a story about the International Rice Festival this past October.
"We prayed hard for 30 days prior to the festival that it be one of peace," he said. "And if you remember correctly it was one of the least problem-filled Rice Festivals we've ever had."


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Wheat Free Chocolate Chip Cookies
by IsaChandra
Makes 18
These cookies couldn't be any easier to make, unless you had someone else make them for you. If you don't need them to be wheat free you can substitute oat flour with regular flour. You can also sub the sugars for and dry sweetener of your choice (Florida crystals, sucanat etc). Oh and by the way, they are yummylicious!
1 small mixing bowl
1 medium mixing bowl
wisk or fork
baking sheet or two
1 3/4 cups oat flour
1/2 teaspoon baking soda
1/4 teaspoon salt
1/4 cup brown sugar
1/2 cup sugar
1/3 cup canola oil *or* melted margarine
1 Tablespoon flax meal
1/4 cup soy milk
1 teaspoon vanilla
3/4 cup chocolate chips
Preheat oven to 375 F.
Sift together flour, baking soda and salt.
In a small mixing bowl, whisk together flax meal and soymilk. Add sugar and stir, add oil and vanilla and whisk vigorously until all ingredients are emulsified (about a minute).
Mix wet ingredients into dry, fold in chocolate chips.
Drop batter by the tablespoon onto ungreased baking sheet, leaving and 1 1/2 inches of space inbetween cookies.
Bake for 10 -12 minutes. Remove from oven and let cool for a bit (5 minutes). Using a spatula, put them on a cooling rack or plate to cool the rest of the way.
There's a problem!
January 23, 2011 at 10:58 pm: TLH
I seem to be doing something wrong with this recipe! I tried it the other night and ground my own flour with oats and all of my cookies flattened out and ran together creating one huge thin cookie! Tonight I remade them using regular flour and the cookies never flattened at all and are very dry! Any ideas?
January 28, 2011 at 9:24 pm: Amanda
Funny, I made these just last week. Below is my post from the Forum. Let me know if any questions and if they still don't come out good for you.
I made the Wheat Free Chocolate Chip cookies this morning. They were delicious! I made a few changes – instead of 1/3 cup of oil, I used 2 tablespoons of oil and close to 1/2 cup of apple sauce (minus the bite I stole from the 1/2 cup portion). And I only used 1/4 cup of the granulated sugar rather than the full 1/2 cup. Plenty sweet and super delicious! I also did what the side note said to do if you don't have oat flour – ground up (quick) oats in my spice grinder. Worked very well.
January 28, 2011 at 9:26 pm: Amanda
OH – and I just realized that the above recipet says 1 tbsp flax meal but I think Veganomicon says 1 tbsp flax seed (which is what I used). I measured out 1 tbsp flax seeds and then ground them in my spice grinder. Don't know if that makes a difference (1 tbsp flax meal vs. 1 tbsp flax seeds)…
February 1, 2011 at 1:28 am: Troy
I wanted to try oatmeal raisin with oat flour and they turned out tasting very good. I combined recipies with a few other on the net. Here is about what I used:
2 c oat flour, 1 1/2 c brown sugar, 1/2 c regular sugar, 1 c coconut oil, 1 quarter of butter, 4 eggs, 1 tsp vanilla, 1 tsp baking soda, 1/2 tsp baking powder, 1 tsp cinnamon, 1/2 tsp all spice, 1/2 tsp salt, 4 c rolled oats, 1/2 c cranberries in half. I started by mixing everything but the ground oat flour with a mixer, mixed in the flour and then mixed in the rolled oats with a spoon. tried 375 for 10 minutes, but cookies ran so dropped to 350 and made smaller cookies and they turned out great. fall apart kind of easy, but delicious.
February 1, 2011 at 1:29 am: Troy
Next time, I think they need to be slightly dryer and they will hold together better.
February 25, 2011 at 4:41 pm: kspar66
Just made em! Great lookin batch to take to a yoga club potluck. My oat flour wasn't extra fine, but they taste heartily decadent. A couple of them make a perfect accompaniment for cozying up with some Classic literature (or less romantically, in my case, making a powerpoint presentation) and listening to rain against my window pane.
July 11, 2011 at 2:13 am: Paola
I made these cookies today and they are spectacular!! I am the only vegetarian in my house, but everybody loved them.
September 27, 2011 at 4:44 am: Deb
If you use melted margarine the cookies will flatten. Just soften the margarine to room temperature . It makes all the difference.
November 12, 2011 at 12:17 am: t
this is a terrible recipe. they taste so bland & fall apart. find a better vegan cookie recipe, don't use this one!!
November 14, 2011 at 12:07 am: Kim
I just fed my uni-cookie to the possum that lives outside my kitchen door.
December 21, 2011 at 8:10 pm: Kristie
Don't use wheat flour. We ran out of oats, so I tried that and they were pretty rough.
After I got less lazy and biked to go get oats, they were scrumptious. Best vegan cookie recipe yet!
June 10, 2012 at 4:55 am: em
SO I used this recipe and added another 1/4 oat flour + used egg replacer + 2 tbsp of rolled oats+ hand full of shredded coconut. After mixing I put in the fridge to chill the mixture.
bake for 10!
Bingo they look great
September 28, 2012 at 3:41 pm: Aleksandra
I just made these but used only 1/4 cup brown sugar and 70% dark chocolate chips and they were spectacular, still sweet and had an ideal shape and texture! Plus they tasted delicious! Even my non-vegan family loved them! Thanks Isa!
December 9, 2012 at 5:16 pm: DeDeNYC
Just made these little darlin's, and they came out just great! To those who seem to be having problems with the batter spreading out and becoming one huge thin monstrous cookie, I have some suggestions (based on my growing experience with vegan/GF baking):
1) After you whisk together the flax meal and soymilk, let the mixture sit for about 10 minutes or so until it becomes "goopy" (yes, that is a scientific term!). This is what's known as your flax egg, the boon of vegan bakers everywhere! This is what will serve to bind your batter together, much as a hen egg does in non-vegan baking.
2) After you mix everything together (i.e., mixing the wet ingredients into the dry and folding in the chocolate chips), allow this mixture to sit for about 10 minutes so that the oat flour can absorb some of the moisture. This will make your batter more "dough-like" and will prevent the mega-spread that comes about if you try to dump the uber-wet initial mixture onto a baking sheet.
Do try this recipe again, with these mods. It really makes a great batch of kind cookies : )
December 22, 2012 at 7:28 pm: sue
I made this sub walnut flour and the cookies were so delicious
December 22, 2012 at 7:35 pm: sue
may I suggest using raw cain sugar it is heather and the cookies non't seem to run together
so many people seem to having problems with this cookie I also have made this with walnut
flour I made my own by blending walnuts in the food processor just make sure it is very dry
blend a handful of crackers first, mine have always turned out great.
April 3, 2013 at 12:20 am: Sasha
I love these cookies! Super simple, quick, and tasty! I really like the taste and texture from the oat flour. I've posted about this recipe on my blog, along with some photos. http://onesmallvegan.com/2013/04/02/veganomicons-wheat-free-chocolate-chip-cookies/
October 30, 2013 at 12:51 am: Joanna
These are fantastic! I love that they are wheat free and vegan and can be made with things i normally have in my pantry, not weird things like xanthan gum…
April 28, 2014 at 4:12 pm: Adrienne
These are the best gluten free chocolate chip cookies I've ever made. I used a flour blend instead of oat flour, and coconut sugar instead of regular sugar, but other than that I pretty much followed the recipe and they were perfect.
May 15, 2014 at 10:16 pm: Nikki
What can I use instead of flax seed. I have IBS and it irritates my tummy.
January 25, 2015 at 6:59 pm: E
Anyone tried using shortening in place of the oil/ melted margarine?
February 1, 2015 at 7:08 pm: Meghan
i was hesitant to try these..no starch, no gum, no almond meal, just oat flour – really? I do a lot of gf/v baking and these cookies are perfect. I used grapeseed oil and cut the sugar to 1/2 cup (used coconut sugar). Keep an eye on 'em while they're in the oven..they do brown quickly. Ignore all the questionable reviews…follow the instructions, make sure your oven is preheated, measure your flour AFTER grinding the oats, grind them finely! in a coffee/spice grinder! not a blender! and don't skimp. These are the best gf chocolate chip cookies I've ever made.
March 7, 2015 at 12:15 am: Lisa
These are great! They only spread out like pancakes if you make your own oat flour and don't grind them fine enough!
And like some other people said: let the flax and milk sit for a while until it thickens and also let the finished batter rest for a few mins before scooping!
OR….. Just add enough oat flour until a soft pliable dough forms!
July 29, 2015 at 7:32 pm: Adeer
I made these yesterday from her book Veganomicon, I wanted something sweet and since I am just learning vegan baking I was looking for something easy and quick these cookies fit the bill. I Loved them my friends Loved them they were a hit..
August 31, 2015 at 5:14 am: Rachel
I have been making these cookies for years. It's my most used recipe in the Veganomicon book. The reason they spread out into a mono-cookie is because of the amount of white sugar you are using. If you divide the sugar evenly between brown and white sugar, (or use less white sugar than brown sugar) the cookie will keep its shape.
Also, I always blend rolled oats for a minute and I use 2 cups of oats, which after blending seem to make 1 3/4 cups oat flour. I double the recipe and add a packet of choc chips (or you can make your own if you blend equal amounts of cacao powder, coconut oil, coconut flakes & dates, then freeze for half hour and break up into pieces).
March 3, 2016 at 3:42 am: Rick
Can this be used to make a pan cookie? My gluten intolerant daughter would like one for her birthday. I was going to double the recipe and spread it onto a round sheet pan.


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Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-I ra, IL-I-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may playa role.
Factors that disrupt circadian rhythms, for example, shift work or altered clock gene expression, are emerging as novel cancer risk factors. 1-4 Circadian rhythm disruption can lead to the development of fatigue, sleep disruption, and depressive symptoms, and these psychological perturbations have been associated with increased secretion of inflammatory cytokines.5-10 Chronic inflammation is an established risk factor for several types of cancer.11,12 Thus, the putative association between circadian disruption and cancer may be driven, at least in part, by immune system dysregulation and changes in the secretion of cytokines that influence inflammation or tumor development. Similarly, polymorphic variation in certain clock genes can result in the phenotypic expression of symptoms related to circadian rhythm disruption, including disrupted sleep and altered mood. 13,14 More recently, certain clock gene polymorphisms have been associated with increased cancer risk 15-18 The human Per3 clock gene is a putative tumor suppressor gene that contains a polymorphic domain expressing 4 or 5 copies of a 54-bp tandem repeat sequence. Variation in this sequence has been associated with circadian preference, sleep and mood disorders, and increased breast cancer risk among premenopausal women. 18-24 Rhythmic changes in Per and other clock genes have been linked with regulation of the innate immune system.25-27 However, no study has examined whether variation in the human Per3 clock gene is associated with altered cytokine secretion. The objective of this study was to test the hypothesis that individuals with fatigue, poor sleep, depressive symptoms or a Per3 clock gene variant genotype have altered serum concentrations of cytokines that can influence inflammation or growth regulation.
The study population consisted of male veterans scheduled for a screening or diagnostic colonoscopy at the Dom Veterans Affairs Medical Center (DVAMC) in Columbia, South Carolina. Data were collected from March through November 2007 between 9:00 AM and 5:00 PM. Following informed consent, participation included a personal interview and collection of a peripheral blood sample for recovery of serum and DNA. All data were collected prior to completion of the colonoscopy; therefore, participants had no knowledge of the procedure outcome at the time of interview. The questionnaire included information on sociodemographic characteristics, lifestyle, diet, employment and shift work, health status, medications and supplements, mental and physical well-being, physical activity,28 time spent outdoors, risk factors for colorectal polyps and cancer, sleep habits, major life events, stress and coping strategies, social support, and validated instruments targeting sleep disruption (Pittsburgh Sleep Quality Index [PSQI]),29 fatigue (Multidimensional Fatigue Inventory [MFI]),30 and depressive symptoms (Beck Depression Inventory II [BDI]).31,32 The study was approved by the institutional review boards of the DVAMC and University of South Carolina.
Whole blood samples used for DNA recovery were collected in ethylenediaminetetraacetic acid–preserved vacutainers and stored in 0.5-mL aliquots at –80°C prior to analysis. Genomic DNA was extracted using the DrGentle protocol (Takara, Japan). After extraction, genomic DNA pellets (50-100 μg) were dissolved in 100 to 200 μL of TE buffer, of which about 200 ng was subjected to polymerase chain reaction (PCR) using a Perkin Elmer GeneAmp System 9700 (Waltham, MA) according to the manufacturer's protocol. The Per3 variable number tandem repeat (VNTR) DNA sequence was amplified using the following primers (forward) 5′-CAAAATTTTATGACACTACCAGAATGGCTGAC-3′ and (reverse) 5′-AACCTTGTACTTCCACATCAGTGCCTGG-3′, with a reaction mixture consisting of 25 μL standard PCR buffer, 5% DMSO, 1.0 mM MgC12, 0.2 mM dNTP, 1 unit Taq polymerase (Gibco-Invitrogen, Carlsbad, CA), and 0.4 μM of each oligonucleotide primer. The reactions were heated to 94°C for 2 minutes followed by 35 cycles at 94°C for 30 seconds, 60°C for 30 seconds, and 72°C for 45 seconds. Finally, the reactions were extended for 7 minutes at 72°C. PCR products were then separated by electrophoresis on a 3% agarose gel to identify homozygous (4-repeat: 4/4), 5-repeat (5/5), or heterozygous (4/5) individuals. Laboratory personnel were blinded to the identity and characteristics of participants, and a 10% random sample was reanalyzed to assess genotyping concordance.
Following collection of a nonfasting venous whole blood sample in a red-top vacutainer, serum samples were clotted at room temperature for 15 to 30 minutes, centrifuged (5000 × g for 5 minutes at 4°C), and 0.5-mL serum aliquots were stored at –80°C until analysis. Serum cytokine concentrations (interferon [IFN]-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1ra, IL-1-β, vascular endothelial growth factor [VEGF]) were determined using a Beadlyte human multicytokine detection system kit (Bio-Rad, Hercules, CA). Filter bottom ELISA plates were rinsed with 100 μL of Bio-plex assay buffer. The assay buffer was then removed using a Millipore Multiscreen Separation Vacuum Manifold System (Bedford, MA) set at 5 mm Hg. Analyte beads in assay buffer were then added to the wells followed by 50 μL of serum or standard solution. The plates were incubated for 30 minutes at room temperature with continuous shaking using a Lab-Line Instrument Titer Plate Shaker (Melrose, IL). The filter bottom plates were washed and centrifuged as before at 300 × g for 30 seconds. Subsequently, 50 μL of antihuman IFN-γ, TNF-α, IL-6, IL-1ra, IL-1-β, or VEGF antibody–biotin reporter solution was added to each reaction well, after which the plates were incubated with continuous shaking for 30 minutes followed by centrifugation and washing. Following this, 50 μL streptavidin–phycoerythrin solution was added, and the plates were incubated with continuous shaking for 10 minutes at room temperature. Next, 125 μL of Bio-plex assay buffer was added, and Beadlyte readings were measured using a Luminex System (Austin, TX) and calculated using Bioplex software. Samples below the limit of detection were assigned a value of one half the limit of detection (0.25) pg/mL for data analyses.
Data analyses were performed using the SAS statistical software package (Version 9.l, SAS Institute Inc, Cary, NC). Values for IL-6, TNF-α, INF-γ, IL-1ra, and IL-l-β were log-transformed prior to analysis, and mean concentrations were transformed back to original units for presentation. VEGF and psychosocial measures (BDI, MFI, and PSQI scores) were analyzed without transformation. One participant had elevated TNF-α and INF-γ concentrations, which were evaluated as potential outliers using the method described by Cook.33 These concentrations met the criteria for Cook's d statistic33 and were within a physiological range; thus, the values were retained in the analyses. A 2-step variable selection procedure was used to identify potential confounding factors associated with each cytokine and psychometric (MFI, BDI, PSQI) variable. First, each independent variable obtained from the questionnaire was compared with each dependent variable using the generalized linear models (GLM) procedure in SAS. Second, screened variables (P < .05) were combined in another GLM model, and factors that were no longer associated with the dependent variable (P > .10) were removed sequentially from further analysis. This step was repeated until a set of statistically significant (P < .05) covariates was identified for each dependent variable, and these were included in subsequent hypothesis testing analyses. To test the study hypotheses, the GLM procedure was used to determine whether mean serum cytokine concentrations (IL-6, TNF-α, IFN-γ, IL-1-β, IL-1ra, and VEGF) differed among individuals grouped according to different circadian disruption symptoms (using MFI, BDI, or PSQI scores) or among those with different Per3 genotypes. Adjusted (least squares [LS]) mean cytokine concentrations were calculated, and differences among symptom categories or genotype were determined using the least significant differences (LSD) statistic, after adjustment for selected potentially confounding factors. BDI scores were used to group participants into categories of normal (≥10), mild (11-20), or moderate to severe (≥21) depressive symtoms.32,34 Poor sleepers were defined as those with PSQI scores ≥5,29,35 and MFI cutpoints were chosen to obtain a distribution of 10 to 15 individuals in several fatigue categories. The relationship between cytokine concentrations and circadian disruption symptoms was also evaluated using each score as a continuous variable in separate GLM analyses. The GLM procedure was used to determine whether circadian disruption symptoms were associated with different Per3 variants by comparing adjusted mean MFI, BDI, or PSQI scores among the Per3 genotypes. Inclusion of polyp status (no polyp detected, benign or hyperplastic polyp, adenoma, or unknown—colonoscopy not yet performed), time of day, or month of sample collection in the statistical analyses did not affect the results obtained.
A total of 83 eligible subjects participated (participation rate = 45%), and complete data were available for 70 men (n = 13 with no blood sample). The average age was 57 ± 9 years, and the racial composition of African Americans and European Americans was approximately equal (51 % and 49%, respectively). Summary scores for general fatigue (mean ± standard deviation = 12 ± 2) and depressive symptoms (14 ± 11) among participants were generally consistent with published normative data (MFI30: 15 ± 7, BDI36: 11 ± 8). The mean global PSQI score in this population (10 ± 5) was elevated, and a bimodal distribution was suggested, with scores centering on approximately 5 and 13 (data not shown).
There were no statistically significant differences in adjusted mean inflammatory cytokine concentrations between those with adequate and poor quality sleep (Table 1). However, poor sleep was associated with a statistically significant increase in circulating VEGF concentrations (P = .04, Table 1). There was no association between serum cytokine concentrations and scores for depressive symptoms, reduced motivation, or general, physical, or mental fatigue (data not shown). Participants with higher MFI subscale scores for fatigue-related reductions in activity tended to have higher TNF-α concentrations compared with those with lower scores (P = .05, Table 2), although the results were of borderline statistical significance.
Genotyping for the Per3 VNTR was in Hardy–Weinberg equilibrium (P = .81), and there was 100% concordance with independently genotyped quality control samples. The overall frequency of the homozygous 5/5 VNTR (10%) or the combined genotype frequency (4/5 and 5/5, 51%) agreed well with previous reports (approximately 7% to 10% and 40% to 54%, respectively).18,37 Evening circadian preference was reported among 67%, 54%, and 57% of participants with the 5/5, 4/5, and 4/4 Per3 tandem repeat sequences, respectively. Table 3 presents adjusted mean cytokine concentrations among individuals with different Per3 VNTR genotypes. Mean IL-6 concentrations were elevated among individuals with the 4/5 or 5/5 VNTR sequence compared with those homozygous for the common (4/4) genotype. Table 4 presents mean scores for sleep, fatigue, and depressive symptoms among those with different Per3 variant genotypes. A tendency toward reduced motivation and a modest increase in depressive symptoms was suggested among subjects with the 4/5 or 5/5 genotype, whereas physical fatigue and sleep disruption tended to be reduced among these individuals compared with those with the 4/4 genotype (Table 4).
Circadian rhythm disruption is emerging as a novel and important cancer risk factor. In experimental animals, circadian disruption induced by simulated jet lag or via light exposure at night results in accelerated tumor formation and increased cancer mortality.38-45 Shift work can have significant impacts on workers; it has been associated with sleep disruption, fatigue, and, in some cases, depression.46-50 More recently, shift work has been identified as a risk factor for cancers of the colon, breast, prostate, endometrium, and lymphatic system,1,51-58 and the International Agency for Research on Cancer classified shift work as a probable human carcinogen.4 The biological mechanisms underlying the association between circadian disruption and cancer remain to be fully elucidated but may involve changes in the secretion of cytokines that control proinflammatory or proliferative processes.
Results from the present study provide some support for this hypothesis. Poor sleep was associated with increased serum VEGF concentrations, and mean PSQI scores among our participants (10 ± 5) were similar to those observed among cancer patients (11 ± 5).35 VEGF is important among cancer patients because its angiogenic properties support tumor progression. Additionally, it may affect risk among cancer-free individuals because it can participate in the development of premalignant lesions such as colonic adenomas.59,60 It has been suggested that VEGF levels may be elevated in depression,61 a condition frequently accompanied by poor sleep,62 although there was no association between VEGF and depressive symptoms in this study. Sleep deprivation has been linked with increased circulating concentrations of several inflammation mediators, including TNF-α, IFN-γ, IL-6, and IL-l in humans.7,8,63-66 Results from our study did not support an association between sleep disruption and circulating inflammatory cytokines, although fatigue-related inactivity was linked with increased TNF-α concentrations. TNF-α is an established mediator offatigue,9 10 and therapeutic strategies targeting this cytokine for fatigue reduction are under development.67,68 Reasons for the inconsistencies among the cytokines measured in this study and results from the existing literature may have been due to the inherent variability of the cytokines measured or due to the cross-sectional nature of the study design. However, we used validated instruments, and our psychometric measures were generally consistent with normative data. We were also able to rigorously evaluate and control for numerous potential confounding factors in the analysis. It may be that multiple, severe, and/or prolonged circadian disruption symptoms are needed to elicit immune dysfunction and robust changes in circulating cytokine concentrations. More detailed longitudinal studies with larger samples and quantitative sleep measures, such as actigraphy or polysomnography, would help in clarifying these issues and in characterizing potential thresholds of biological dysfunction and disease risk that may be linked with circadian disruption.
The molecular clock responsible for human circadian rhythm generation consists of 9 core clock genes, and their expression has been characterized in virtually every tissue investigated.2,69-71 Clock genes regulate the timing of DNA repair, apoptosis, and cell proliferation, processes that are hallmarks of carcinogenesis.2,72,73 About 5% to 15% of genome-wide mRNA expression exhibits a circadian rhythm that is driven by the clock genes, including some established tumor suppressor genes and oncogenes.74,75 Mutation or dysregulation of the Period or other clock genes has been associated with increased cancer susceptibility in several animal models as well as in human populations.15,17,18,76-80 The Per3 gene has a polymorphic repeat region with 4 to 5 copies of a 54-bp repetitive sequence in exon 18. This variation results in an insertion/deletion of 18 amino acids, and it has been linked with sleep and mood disorders and circadian preference in humans.19-24 A recent breast cancer study found that the 4/5 or 5/5 Per3 VNTR was more common among premenopausal cases (63%) than controls (49%; odds ratio = 1.7; 95% confidence interval = 1.0-3.0).18 In the present study, individuals with the 4/5 or 5/5 genotype had higher adjusted mean IL-6 cytokine concentrations compared with those with the 4/4 genotype. IL-6 is a pro inflammatory cytokine involved in tumor progression81 that can induce expression of the Perl clock gene.82 Although the function of human Per3 in conjunction with IL-6 is currently not known, results from the present study suggest a need for additional research to determine whether the cancer risks associated with the Per3 VNTR variant may be related to elevated IL-6 or other inflammatory cytokine concentrations.
In summary, chronic inflammation is a known risk factor for cancer, and symptoms of depression, fatigue, and sleep disruption are associated with inflammatory cytokine secretion. However, few studies have attempted to determine whether the association between circadian disruption and cancer is driven by the secretion of inflammatory cytokines. Results from this study suggest that individuals with poor sleep had higher VEGF concentrations compared with good sleepers, participants with greater fatigue-related inactivity had higher TNF-α concentrations, and those with a 4/5 or 5/5 Per3 variant genotype had higher mean IL-6 concentrations compared with referents. The results provide some support for the hypothesis that fatigue, poor sleep, or the Per3 VNTR polymorphism is associated with elevated serum cytokine concentrations. If a link between circadian disruption and inflammation is established, therapeutic strategies targeting improved circadian hygiene may provide a benefit by ameliorating inflammation and reducing cancer risks.
Declaration of Conflicting Interests
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors disclosed receipt of the following financial support for the research and/or authorship of this article: This research was supported by the Arnold School of Public Health and Center for Colorectal Cancer Research, University of South Carolina, Columbia, South Carolina. Dr Burch was supported by a Career Development Award from the US Department of Veterans Affairs, VISN-7, Charleston, South Carolina, by the William Jennings Bryan Dorn Department of Veterans Affairs Medical Center, Columbia, South Carolina. Dr. Hébert was supported by an Established Investigator Award in Cancer Prevention and Control from the Cancer Training Branch of the National Cancer Institute (K05 CA136975). Dr Xie was partially supported by Contract No 212-2008-M-24052 from the Biostatistics and Epidemiology Branch of the National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Skip to comments.Voting for Romney? Where is your line in the sand? (Vanity)
Posted on 04/26/2012 9:18:03 AM PDT by Student0165
I want to ask those who consider themselves conservatives, and are going to vote for Romney because he happens to have an (R) instead of a (D) behind his name on the ballot sheet, where do you draw your personal line in the sand and say "No more"? For stupid people reading this (liberals and DHS type workers), I don't mean violence - I mean not voting for "the lesser of two evils".
Straw man argument.
DUers jerk off to these kinds of threads.
Terrorists crouch on carpets praising Allah for your success at dividing Republicans.
How soon before I see the Drudge headline that the once-great conservative website Free Republic is now flat-out PRO-OBAMA?
Shame on you.
Because the only consistant trait she has displayed is to know where her bread is buttered.
Thanks for your reply: At this point, to be a true conservative.
Was there anyone in the primary that met your standard?
DA-Da-Da, America-America...flags waving, crowds cheering...or....
Indeed (and thank you!). Also, I haven't seen voters as generally unenthusiastic, and even downright angry, as they are since 1992.
It seems as though you let your slip show on another thread..."Let the kenyan keep it another 4 years."
And you serve what purpose? (I mean besides pretending to be a "student".) Let me guess...Third Party?
Won't work this time. Obama and his march to Marxism is over. And there's nothing you can do about it.
Naive, at best.
GOP elite holds off the tea partiers
April 22, 2012
SCOTTSDALE, Ariz. The Republican Party establishment has withstood the tea-party revolution.
The tricorne-hat wearing, Gadsden-flag waving insurgents were nowhere near the Republican National Committees annual meeting of state chairman, which wrapped up at a posh resort here Saturday afternoon.
Many Republicans here said that tea-party activists now understand that things will run more smoothly if those with experience are in charge rather than those who put a premium on ideology over process.
*end excerpt*
It seems as though you let your slip show on another thread...Let the kenyan keep it another 4 years.
All I did was ask a question. It is so telling to see the fear and hatred come out of the Romneybots. Interesting.
I find your post doubly-ironic, considering your tagline.
BTW: Everything you talk about doing to create this third party could be done within the GOP easier and quicker.
If you can't exercise the same skills and success within the party, I don't believe you can do it outside. It's been done before, it can be done again.
The problem this primary was a weak field and disunity - no organizing behind a single candidate opposed to Romney.
No, you have misapplied the term "straw man argument". Does not fit in response to my personal statement, which is provable. Nothing about my statement was a construction to be demolished.
"...if the only way to get rid of Obama is to cast a vote for Romney then thats what Ill have to do (even it if means walking outside and throwing up afterwards)."
I've already scheduled an appointment with my doctor to have my tongue stitched back together after I pull the lever for RINO-Romney.
Whatever it takes to be get the zer0 out!
You mean the guy who was polling 40+% consistently throughout June of 1992? The guy who only lost because he more or less self-destructed like a crazy man?
Not actually a very good example to make your case. A non-crazy conservative could mount a winning campaign.
Like it or not, politics is a numbers game, and the majority of the electorate is not conservative.
Sure they are - they just need to be made to understand this fact.
Harsh judgment. Oh well, that is the presstitutes' line they've spread about her. For those willing to dig into the subject, it is possible to discover what you wrote is not quite the truth.
How do you NOT know this?
———In four years we will have other candidates———
The rest of the lesson is very plainly visible here on Free Republic. There is no such thing as a "Conservative". There is an extremely wide variation of views with specifics among individuals quite variable. There was no consensus enabling one candidate to be thrust the forefront. It seemed that what was good didn't matter. It was that which caused one to be against that prevailed.The result was smaller coalitions of those who could accept that which others, other conservatives disdained.
Then there is poor ol' pissant. He got so riled and vociferous, he got zotted.
My solution is a CONSERVATIVE SECONDARY. A method must be developed to weigh and measure qualifications, develop consensus, and result in one or at most two conservative candidates in the Republican Primary.
We do not need a third party. We need a strong Conservative Coalition residing under the Republican tent. It might be a Tea Party Coalition but with several competing Tea Parties it may never come to pass. Bravado and "By God I won't ever vote RINO" must be softened by developing real strength in a coalition.
Until such a coalition is existing and functioning, the probability for prevailing at a national level is slim.
I think it should be Newt's job and legacy to begin just such an effort
I'd love to see how the Founding Fathers would contend with today's massive and corrupt government beaurocracy and dumbed-down, left-leaning electorate.
Not naive. Those state chairman you blame, can be replaced. They very often are.
If you can't organize and replace those positions in the GOP, you can't do the same thing in a third party - it's the same work and skills.
Further, if you have a third-party, you'll have the identical task of filling those slots with those folks you want - and the same arguments and fights.
The only difference is you have a ton of extra work for a new party that you don't have organizing and changing an existing party.
It's more than just running a non-crazy candidate. You have to have someone of real stature. The electorate needs to be very, very angry. There could be a Conservative party victory and permanent replacement of the Republican party but I think without these things it ain't gonna happen.
Skimmed through the first 100 posts, and as usual not one, not one confirmed policy change Mandate-Mitt in any post, not one.
Federal Bloc. dream candidate. Mandate-Mitt, the most unknown mandate dangerous Federal Takeover candidate ever. No wonder they want the Undocumented Coffee Server out.
Some of them would be posting or lurking on Free Republic trying to figure out what to do.
From Wiki: A straw man is a component of an argument and is an informal fallacy based on misrepresentation of an opponent's position. To "attack a straw man" is to create the illusion of having refuted a proposition by replacing it with a superficially similar yet unequivalent proposition (the "straw man"), and refuting it, without ever having actually refuted the original position.
Nobody here has argued that the GOP will automatically receive conservatives' votes.
Nope. It's already been tried. It didn't work. Face it - as much as you want to believe otherwise, the GOP simply is not a place for conservatives anymore.
Once Palin decided not to run, I could have held my nose and voted for Gingrich.
Both of these have sizable and vocal opposition here. The problem is closer to home than blaming the party, IMHO.
Start a third party and I believe you will have the same problems, the same arguments, the same disunity. Until this is overcome, nothing really changes.
And I bet you donated a kidney to a homeless vet. What a load.
A) I spent two decades trying to fix the GOP. Like I told you, it's a pipe dream. And with the impending nomination of Romney, the situation just got infinitely worse.
B) I've spent four years building a new party, and we're doing just fine, with a minimum of "arguments and fights." And we're doing it on a completely principled basis.
Poll results 6 months before elections aren't particularly relevant.
I voted for Perot. It was a dumb mistake. Lesson learned.
I don't vote for Socialists, whether Republican or Democrat.
Mitt 0bamney is therefore disqualified from the possibility of receiving my vote.
That was an utterly stupid and worthless reply. You made a claim that you cannot possibly know to be true and I called you on your b.s.
I watched it and worked in and for it when it did work during the Reagan years.
The party is not a separate monolithic entity - it is comprised of people. It's not exactly the same from one month to the next, one election to the next.
Politics is messy and a long hard continuous slog, from the bottom to the top. The work and results are the same within the GOP as they would be in a new party, except you'd have much greater obstacles to overcome in a new party.
"A non-crazy conservative..."
Leftists, Romneybots, and several recent posters on Free Republic would say that's an oxymoron even if not talking about Ross Perot.
I have to agree with this. I know many Freepers are blaming the GOPe for giving us Romney, but my view is that we did not have a strong slate to begin with. I really wanted Palin to run and then went for Cain until it dawned on me that Newt was the smartest man on the stage. Now, I am going to do everything I can to keep the Kenyan from having a second term. NO ONE is more evil than him and his minions.
What we need to ask ourselves is why didn't a really STRONG conservative throw his/her hat in the ring? Didn't we have someone other than Palin?
Good grief, you *are* naive, aren't you?
Replaced by whom, another state chair whose jib is cut the exact same way. State party politics are almost always driven by personality more than ideology, except in very rare circumstances where a determined ideological minority raises enough of a ruckus that the rank and file wakes up for a moment and gets mad enough to turn out in force at county conventions.
Most of the time, however, when one state chair (or other top official) is replaced, it has to do with factional politics - one guy's circle of followers was able to finagle a way to get the other guy thrown out.
What line is it you speak of? I choose between the choices that have qualified to be on the ballot based on what is the best for America.That always means not voting democrat.
as long as America is still a free country, I will vote in every election. I will vote for Romney, since not voting is not an option for me. I won't vote for a Marxist, and not voting is a vote for the Marxist.
One reason it would kill the Whig party for certain.
I'm not insinuating a third party like some harridans on this thread (who do not know me) are contending. I don't believe a third party will work with our election system. I am, however, fed up with fear voting and I asked a simple question about where conservatives draw their voting line in the sand when it comes to the same old Dole/McCain/Romney - and even Bush candidates.
Thank you for your sane replies.
Enjoy the next 4 years of Obama then.Hope he doesn't end your jobs in those 4 years.
A: So that we don't have two identically Socialist Parties in the U.S., the Red Socialists and the Blue Socialists, with no essential distinction.
I'll take the Real Socialist to maintain the distinction between Socialism and Non-Socialism forever. To eliminate the distinction is the greatest harm. I'd rather lose fighting for actual freedom than win my own prison cell.
I'm sure of it. :-)
Perhaps, one day, we will learn the true reasons she didn't run...so far.
It is easy to state, as many here do, that Romney was wired for the nomination by the scoundrels of the GOP-elite.
It is much harder to identify the solid conservative candidate that we would all have rallied behind had not the GOP-e evildoers done their dirty.
Re Romney in 2016: Also, he has the money to run again, has made it clear there's nothing he'd rather do for years on end than run for President, would surely get the GOP-e backing all over again.
My experience was different, it was successful. If you're unsuccessful there are reasons for it.
If your third party grows to any size, say the size necessary to get on the ballot and run a credible national campaign, you will have fights and dissension and same problems you have with the GOP.
Because the only way not to is to not have very many people involved.
The politics of freedom are a messy affair.
You are a mewling little coward with a stream of Mitt running down your chin. It ain't pretty little lady.
Well said.
You "called me on my b.s." Sure. Is that what they're calling "spewing idiocy" these days?
You're right - I don't *know* that a third party would win under the circumstances I've described. True enough. I also don't *know* the outcome to a lot of other events which are still over seven months away. Nobody does. Ergo, you're question was a stupid irrelevancy serving as an inadequate substitute for actual thought, designed to justify your own personal lack of courage.
At least I provided a framework argument for why a third party *could* have a better-than-fair chance of winning it all. You didn't even attempt to provide reasons why it couldn't. Throwing your diaper at me doesn't count, btw.
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Important Terms for Students
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