text:
Hostelworld anbefaler
Vi er vilde med dette hostel! Vi giver det tommelfingeren op for dets altid høje kundevurderinger og fremragende kvalitetsscore.
Sammenlign resultater
Hvornår ønsker du at opholde dig i Hoi An?
Indtast datoer og check ledighed
- Søg efter tilgængelighed
- 30 sep 2016, 3 Nætter
- 2 Gæster
- Ændre søgning
- 30
- 60
- Alle
- Pris
- Vurdering
- Afstand
- Navn
Phuong Le Villa - Vietnam Hideout Hostels57 Thoai Ngoc Hau, C... 40.8kmUS$7.00
- Vis:
- Liste
- Galleri
Hoi an Life Homestay
Hoi An Life Homestay is located in Hoi An just 700 metres from Hoai River and 3.3 km from Cua Dai Beach. The homestay provides elegant accommodation equipped with hot shower facilities, free breakfast... Mere...
Phuong Nam Hotel & Villa
The Southern Hotel and Villa is located just minutes away from the Da Nang Beach coast and within walking distance to the world-renowned heritage town center of Hoi An, the Southern Hotel (known as Ph... Mere...
- Pris Værelsestype
Loc Phat Hoi An Homestay - Villa
Loc Phat Hoi An - Villa is run by Mrs. Linh, whose family has lived on the same property for 4 generations. It's named after my sons, Phat (which means development) and Loc (Luck). My roots stre... Mere...
Cloudy Homestay and Hostel
Van Homestay is a 10-minute bicycle ride from the white sands of Hoi An's coast. It offers free bike rental and motorbike rental is 6$ for all day .
The accommodation will provide you with a... Mere...
Little Leo Homestay and Hostel
Little Leo Homestay is a 10-minute bicycle ride from the white sands of Hoi An's coast. It offers free bike rental and motorbike rental is 6$ for all day .
The accommodation will provide you... Mere...
Nhi Trung Hotel
Nhi Trung hotel is located in the center of Hoi Ans Old Quarter with traditional architecture in 24 fully equipped rooms. It is 28 km from Da Nang International Airport. It is designed in an Oriental... Mere...
Tribee Cham
The ROOFTOP is UNIQUE to Hoi An. You will be totally free to make friends with other backpackers and share your adventures while lying on our DIY colorful couches, surrounded by a lots of trees.
... Mere...
Paddy's Hostel & Bar Hoi An
Paddy's Hostel & Bar is ideally located only a 5min walk from Cua Dai beach and a 15 min cycle from the ancient old town of Hoi An.
We provide free bicycle rental, laundry service, towel renta... Mere...
- Pris Værelsestype
Sunshine Hotel Hoi An
Sunshine Hotel is a 3 star Hotel with 36 balcony-room and night swimming pool.
The hotel is located on a good location, midway between the Hoi An ancient town (5 minutes by bicycle) and the beach,... Mere...
- Pris Værelsestype
Phuong Le Villa - Vietnam Hideout Hostels
Phuong Le Villa is the ultimate chill-out hostel, we have just relocated to a brand new building so everything is new too. You get 1 free beer each day, free big breakfast, super comfy beds (not bunks... Mere...
Sunflower Hotel Hoi An
Sunflower hotel is located between two location that Hoi An ancient town and Cua Dai beach easy and convenient for you travel shopping and swimming
Downtown hotel is only 500m from town with a 10 min... Mere...
Hoa Binh Hotel
Hoa Binh Hotel is a comfortable and relaxing 2 star hotel. It is located in a quiet area center of the town, nearest the World Heritage ancient quarter.
Our hotel is the best way to enjoy your st... Mere...
Sac Lo Homestay and Hostel
Sac Lo Homestay features air conditioned dorm rooms and private rooms. The dorm rooms are 3-4 beds air conditioned and cleaned daily with private balconies, safes and washrooms - towels included.. Th... Mere...
- Pris Værelsestype
Iris Villa Hoi An
At Iris Villa, friendly staff can assist guests with laundry/dry cleaning services and airport transfer arrangements.
Tastefully-furnished, air-conditioned rooms come with tiled flooring, a wardrob... Mere...
- Pris Værelsestype
Hoi An Paradise Hotel
Our first class facilities ensure Hoi An Paradise Hotel is the perfect place to enjoy a relaxing holiday, a business break or romantic gateway. The hotel has a large freshwater swimming pool, and a to... Mere...
Backpackers home homestay
Backpackers Home Homestay has small air conditioned dorm rooms and private rooms. The dorm rooms are 4 beds air conditioned and cleaned daily with private balconies, safes and washrooms - towels inclu... Mere...
Hoi An Villa River View
Villa Riverview is situated approximately 1.5 km from Cua Dai public beach. It features well-appointed guestrooms with air conditioning and free Wi-Fi access. Cooking classes are available upon reques... Mere...
- Pris Værelsestype
Long Life Hotel
Long Life Hotel warm-heartedly welcomes everybody to Hoi An. It is a top resort hotel, the precious island in the heart of Hoi An.
Within a few minute walk from the center, the hotel will surprise y... Mere...
- Pris Værelsestype
Blue Clouds Hotel
Our simple but comfortable rooms offer:
- Refrigerator
- Air-conditioning
- Ensuite bathroom
- Flat screen television
- Wardrobe space
- Towels and toiletries are provided
So what... Mere...
Offering a barbecue and terrace, Hoi Pho is set in the Cam Pho district in Hoi An.
Some units feature a seating area where you can relax.
You will find a 24-hour front desk at the property.
T... Mere...
- Pris Værelsestype
Hoi An VIVA Homestay
Welcome you all to our house Hoi An ViVa Homestay for better learn Hoi An Lifestyle as well as improve your Vietnamese!
After few minutes cycling from Hoi An VIVA Homestay, you will be able to visi... Mere...
- Pris Værelsestype
Countryside Moon Homestay
Located in Hoi An, Countryside Moon Homestay offers elegant and comfortable accommodation with free WiFi access throughout the property. Operating a 24-hour front desk, it features a garden restaurant... Mere...
- Pris Værelsestype
Hoian Salute Hotel
Hoian Salute Hotel & Villas offers good value accommodation. The hotel offers an outdoor pool and modern rooms. Rooms at the Hoian Salute Hotel & Villas are spacious, clean, have comfortable b... Mere...
- Pris Værelsestype
Strawberry Garden Homestay
Situated in Hoi An's Thanh Nam Fishing Village, Strawberry Garden Homestay features rooms with a balcony and large windows offering calming views of the strawberry garden. It also offers complim... Mere...
- Pris Værelsestype
Tropical Garden Homestay Villa
Located in Tra Que vegetable village an attractive destination for domestic and foreign tourists, long known to many vegetables have its own unique flavor.
Tropical Garden Villa Homestay with peace... Mere...
- Pris Værelsestype
House Backpacker's
House Backpacker's has nice rooms, each with a balcony and window. All of the rooms are equipped with modern facilities such as air conditioning, fan, hot showers, wifi, etc. There is the computer net... Mere...
Huy Hoang Garden Hotel
HUY HOANG GARDEN HOTEL was located on the area of 1,500 square meters, including 32 rooms with all international standard facilities & equipments. Swimming pool with 60 square meters besides the n... Mere...
River Park Homestay and Hostel
The way lead to An Bang beach, River park homestay and hostel offers private and dormitary room with good air-condition and ensuite bathroom.
Hoi an River park homestay and hostel is front of river... Mere...
- Pris Værelsestype
Golden Lantern Homestay
Our homestay is situated 4 km out of the old town of Hoi An in the beautiful surroundings of Hoi An. From here, you can enjoy cycling to the centre or through rice paddies and to the beach.
We hav... Mere...
Petunia Garden Homestay
With this scenery, Petunia Garden Homestay brings you relaxing and peaceful atmosphere when being in harmony of nature and seeing how simple life of the gardeners is going on. In addition, the city ce... Mere...
- Pris Værelsestype
Hostelworlds mobilapps
Bestil, mens du er på farten, med de nye Hostelworld mobil-apps.


text:
In Stores This Week Around The World
Written Monday, July 05, 2010 By Richard WalkerView author's profile
This week is incredibly quiet and would be even quieter were it not for the release of Crackdown 2 (Riot Act 2 if you're in Asia), which explodes into stores around the world.
Expect things to stay like this for a while, as summer takes over and the sun begins to shine. Perhaps it's a sign that we should all go outside and play? But wait...it buuuuurnssss!!! And there's 900+ Crackdown 2 orbs to collect!
Best stay inside then.
Look out for our Crackdown 2 review, later today.
Asia (via play-asia.com)
- Riot Act 2
- Dead To Rights: Retribution
Australia (via ebgames.com.au)
- Crackdown 2
Europe (via game.co.uk)
- Crackdown 2
- Tekken 6 (Classics)
North America (via gamestop.com)
- Crackdown 2

subset: commoncrawl


text:
Latest News
26 January 2016
26 January 2016
—EMD 2016 Conference will be held in Turku, Finland, on 18 and 19 May 2016. If you cannot participate you may organise your own EMD event elsewhere in EU.
21 January 2016
21 January 2016
—The Commissioner for Environment, Maritime Affairs and Fisheries Karmenu Vella will travel to Warsaw on 21 and 22 January for talks with the Polish Government.
20 January 2016
20 January 2016
—Did you know that aquaculture products make up a quarter of seafood consumed in the EU? Or that the EU is the 8th largest aquaculture producer in the world – even if its share is only 1.53%?
3 March 2016
Registration is open until 25 February 2016
Deadline: 31 March 2016
13 January 2016
13 January 2016
—The head of the Directorate-General for Maritime Affairs and Fisheries, Joao Aguiar Machado, is currently in Portugal for an official three-day visit (13 to 15 January).
12 January 2016
A new multilingual poster showing the most common aquaculture species.
7 January 2016
7 January 2016
—The Netherlands have taken over the rotating six-month EU Presidency as from 1 January 2016. For fisheries, the new Presidency has announced its aim to achieve more "in-depth sustainability" as agreed in the framework of the EU's reformed Common Fisheries Policy.


text:
"Now that the album is finally finished it's back to Good Fridays" – Kanye West
Listen to '30 Hours' below.
• Opportunist • Leave a Comment
• Opportunist • Leave a Comment
Here's how the Kanye West and Wiz Khalifa beef started. Besides the fact of Khalifa's past relationship with Amber Rose.
Kanye changed the name of new album from "Swish" to "Waves" see below:
#Waves the album formally known as Swish 😭😭😭- Kanye West
Wiz then tweeted: Please don't take the wave. Max B is the wavy one. He created the wave. There is no wave without him. Im a wavy baby for sure and I'm not having it. He's the reason I sing on all my songs. That's the wave. If theres nothing wit that sound ITS NOT WAVY.
Kanye followed up with: All respect to Andre Harrel and Max B #Waves
Wiz Khalifa responded: "Yea aight" to Kanye's tweet. Then added, "Hit this kk and become yourself."
Kanye proceeded to RIP apart Wiz Khalifa after that comment.
Check out all of Kanye's tweets below.
Oh niggas must think I'm not petty cause I'm the best that's ever made music
Like, oh that's Ye and I can put his wife's initials on my twitter @Wizkhalifa/
Bro first of all you stole your whole shit from Cudi
Second, your first single was corny as fuck and most there after
You have distracted from my creative process
I went to look at your twitter and you were wearing cool pants
I screen grabbed those pants and sent it to my style team #Wizwearscoolpants
3rd no one I know has ever listened to one of your albums all the way through
4th you let a stripper trap you
5th I know you mad every time you look at your child that this girl got you for 18 years
6th don't ever come out the side of your neck at me
7th I am your OG and I will be respected as such
8th I made it so we could wear tight jeans
9th me and Cudi created this shit
10th don't you ever in your fucking life speak sideways about a nigga that's fighting for us I do this for all of us
11th I showed you respect as a man when I met you
12th You wouldn't have a child if it wasn't for me
13th You own waves???? I own your child!!!!
14th Nigga it's called creativity #youshouldtryitsomeday
15th Nigga I tried to call you and you changed your number
16th don't even hint at mentioning me my family or my wife I am your OG
17th I think you dress cool I wish I was skinny and tall
maybe I couldn't be skinny and tall but I'll settle for being the greatest artist of all time as a consolation
Don't ever ever ever come out the side of your mutherfucking neck bro or bruh or however you say it Mr. Waves
I'm YE and I ain't gotta say it the right way I'm Ye I'm Ye I'm Ye I'm Ye I'm Ye I'm Ye I'm Ye
Thank you for the extra promotion #WAVES available February 11th
• Opportunist • Leave a Comment
• Opportunist • Leave a Comment
Kanye WEst and his wife Kim Kardashian-West welcomed their second child, a baby boy, earlier this morning on December 5th.
"Mother and son are doing well," the couple said in a post on Kardashian's official website.
Check out the post here.
Kanye called into Hot 97 to address a rumor that he had kids kicked out of a Chuck E. Cheese. While, stating that rumor was 100% false, West also discussed the mark he has made on the world.
• Opportunist • Leave a Comment
Shaquille goes in on a Kanye instrumental for a Birthday Freestyle to Mr. West!
Watch the video below.
Roc Nation artist Vic Mensa just drop the video for his new single "U Mad". The video features a shirtless Vic fighting off men dressed up in riot gear. "U Mad" is the first single off Vic's debut album Traffic, that is due to drop later this year


text:
Thomas Wainfleet
From Wikipedia, the free encyclopedia
Thomas Wainfleet (by 1463–1515), of Canterbury, Kent, was an English politician.
Wainfleet was the son of Thomas Wainfleet of Canterbury. He was unmarried, but had an illegitimate son.[1]
Active in local politics, he was a common councilman for Canterbury by 1500, an alderman by 1504 and mayor for 1514-15. In 1512, he was elected a Member of Parliament for Canterbury.[2]
|Parliament of England
|Preceded by
William Crump
Thomas Atwode
|Member of Parliament for Canterbury
With: John Hales I
|Succeeded by
Thomas Atwode
John Hales I
|This article about a Member of the Parliament of England (up to 1707) is a stub. You can help Wikipedia by expanding it.


text:
Rent The Birth Partner 3rd edition today, or search our site for other textbooks by Penny Simkin. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Harvard Common Press.
Need help ASAP? We have you covered with 24/7 instant online tutoring. Connect with one of our tutors now.


text:
Apple lops $500 off the price of SSD-based MacBook AirWith the price of NAND flash memory continuing its steady sequential decline, Apple Inc. this month cut the price of its Solid State Drive (SSD)-equipped MacBook Air by half a grand, AppleInsider has discovered.
The Cupertino-based Mac maker is now selling its super slim 13-inch 1.8GHz MacBook Air with a 64GB Solid State Drive for $2598, down from the $3098 fetching price that was listed as recently as last week.
The half-grand markdown is a result of price cuts to two separate components. First, Apple reduced the price of the Air's 1.8GHz Intel Core 2 Duo processor upgrade by $100 to just $200.
Secondly, the company slashed the cost of the Flash memory-based 64GB SSD drive upgrade to $599 from $999. That means customers can now configured a 1.6GHz MacBook Air with an SSD drive for as little as $2398.
On Topic: Current Hardware
- New USB-C-to-HDMI spec will enable adapter-free display hookups for MacBooks
- Microsoft's new Surface Pro 4 ad targets feature gaps in Apple's MacBook Air
- Apple's Mac sheds marketshare in Q2, sinks to 5th place amid worldwide sales slowdown
- Roundup: The best external monitor alternatives to Apple's discontinued Thunderbolt Display
- Apple discontinues Thunderbolt Display, no replacement announced


text:
Hotels in Indian Point
Search all hotels in Indian Point
Get Secret Prices on select hotels
These prices aren't available to everyone.
Trending now in Branson
- Most bookedStill Waters Resort
86 people looked at this hotel in the last hour
Most recent review
"A lot of activities free on site great for families"
A Traveller, Sep 2016, US
41 people looked at this hotel in the last hour
Most recent review
"It was very comfortable. The view and rooms were amazing.If we go to Branson we would rent another condo."
A Traveller, Aug 2016, US
39 people looked at this hotel in the last hour
Most recent review
"The Cliffs was just what the doctor ordered! We wanted a place away from the busy strip, with a view and clean. The property was great, quite, clean and reasonably priced. The staff was great and the property manager was awesome! We will for sure book our vacations here in the future. "
A Traveller, Sep 2016, US
39 people looked at this hotel in the last hour
Most recent review
"As others have said, this place is cozy comfort like staying at grandmas. This description is double-edged as this is not like staying at a professionally run Bed & Breakfast, but more like AirBnB. Like the rest of the stay, breakfast is comfortable, familial and involves all the guests. Beaut..."
A Traveller, Jun 2016, US
39 people looked at this hotel in the last hour
Most recent review
"This place was great. If you're looking for 5star service, hoity-toity expectations with no bugs or wildlife, this is NOT your place. If you are looking for peace and quiet,the smell of nature, very nice staff,great 2 level cabins/AC,crickets, swimming pools(indoor and out),being real close to..."
A Traveller, Sep 2016, US
29 people looked at this hotel in the last hour
Most recent review
"Great stay at Eagles Nest. Condo was very clean! Great location...extremely easy to get to Silver Dollar City! However, I don't advise going to town for breakfast before going to Silver Dollar City or you will be fighting traffic on your way back."
J, Sep 2016, US
28 people looked at this hotel in the last hour
Most recent review
"Accomodations were perfect, beautiful location. Two suggestions, add an hour to beginning and end of office hours and give extra wash clothes. Washers and dryers are provided but it doesn't seem very Eco-friendly to have to run a washer daily. Everything else was well supplied."
G, Jul 2016, US
17 people looked at this hotel in the last hour
Most recent review
"we were there with our whole family but the air conditioner was broken in one room and wasn't fixed before we left, which was frustrating. The staff, though, was very nice and the location is great if you're visiting the amusement parks."
A Traveller, Jun 2016, US
17 people looked at this hotel in the last hour
Most recent review
"We stayed at hunters friend last week with our two daughter for vacation. Our stay here was wonderful from the time we checked in to the time we checked out. My girls loved that the pool was open 24 hours a day and our room was great and very nice. we will book here again the next time we take ..."
A Traveller, Aug 2016, US
16 people looked at this hotel in the last hour
Most recent review
"Pool has music playing and Tiki bar, lake surrounds Room was clean, some furniture could use updating, but nice overall"
A Traveller, Jun 2015, US
Map of hotels in Indian Point
- Branson Landing
- Silver Dollar City
- Table Rock Lake State Park
- Dixie Stampede Dinner Attraction
- White Water
- Tanger Outlets
- Moonshine Beach
- Sight and Sound Theatres
- Titanic Museum
- Dogwood Canyon Nature Park
- Branson Convention Center
- Andy Williams Moon River Theater
- College of the Ozarks
- Ripley's Believe It or Not
- Holiday Hills Golf Club
- Lawrence Welk Champagne Theater
- Starlite Theatre
- The Mansion
- Point Lookout
- Clay Cooper Theatre
What you should know about Indian Point
Are you looking for a cheap Indian Point hotel, a 5 star Indian Point hotel or a family friendly Indian Point hotel? You just landed in the best site to find the best deals and offers on the most amazing accommodations for your stay.
When you search for hotels near Indian Point with Hotels.com, you need to first check our online map and see the distance you will be from Indian Point, Missouri.
Our maps are based on hotel search and display areas and neighborhoods of each hotel so you can see how close you are from Indian Point and refine your search within Branson or Missouri based on closest public transportation, restaurants and entertainment so you can easily get around the city. All the hotels details page show an option for free or paid onsite parking.
If you wish to see the hotels with the highest featuring discounts and deals near Indian Point, simply filter by price/ average nightly rate. We recommend you filter by star rating and read our genuine guest reviews so you can get the best quality hotel with the best discount.
One of the new features on Hotels.com guest reviews is that also show reviews from Expedia for Indian Point hotels and the TripAdvisor Indian Point hotels reviews so you can make sure that you checking with a reliable source. See the review scores on our Branson hotel information pages.
Make the most out of your family vacation when you book your accommodation with Hotels.com – book your hotel near Indian Point, Branson after reviewing the facilities and amenities listed for each hotel.
After booking your hotel near Indian Point, expect to receive your reservation confirmation in the mail in less than 10 minutes. The confirmation email contains more information on all nearby attractions, local directions and weather forecast, so you can better plan the days during your trip.
After getting the best hotel rates you can still save more by winning 1 free night! That's right, book 10 nights in any hotel near Indian Point, Branson and after you sign up for the Welcome Rewards program, you are eligible hotel you receive 1 night free*
The best hotel deals are here: We have Indian Point hotel deals, Indian Point last minute deals and offers to get you the cheapest Indian Point hotel with our lowest price guarantee.


text:
Looks like Brookwood is no longer available on Rent.com which means this information is likely out of date.
Make sure to check out these similar properties in the area.
Brookwood Apartments -- Sparkling Pool-- Newly Built Play Ground-- State-Of-The-Art Fitness Center-- Spacious Floor Plans-- Great Location-- Built In Entertainnent Center-- Clubhouse-- Professional On-Site Management Team
Lease terms are variable. Please inquire with property staff.
Pet Policy: Maximum 2 pets per apartment. $30.00 pet rent. Restrictions: No weight limit.
Dogs Allowed. Cats Allowed. Pets Accepted. Call for service animal policy.
404 units
Don't have a Rent.com account? Create one.
Creating an account allows you to acccess your saved and contacted properties on any device. Already have an account?
Log In
We are experiencing technical difficulties at the moment. Please try again later.


text:
Hostelworld poleca
Uwielbiamy ten hostel! Ma naszą pełną aprobatę za niezmiennie wysoką ocenę klientów i świetną jakość.
Porównaj wyniki
Kiedy chcesz zatrzymać się w mieście Naxos?
Podaj daty, aby sprawdzić dostępność
- Szukaj wolnych miejsc i cen
- 27 Wrz 2016, 3 Noclegi
- 2 Gości
- zmień kryteria wyszukiwania
- Cena
- Ocena
- Odległość
- Nazwa
- Widok:
- Lista
- Galeria
Studios Margo
Margo Studios is combining the traditional island style with the modern updates in order to offer comfortable stay in a great atmosphere at the best price.
It is located at a quiet area of Naxos Town... Więcej...
Soula Hotel
A friendly family run hotel & hostel located in the sandy Saint George beach. It offers free transfer from/to the port and airport, free luggage storage, free internet access, free wireless intern... Więcej...
Windmill Naxos
The Windmill rooms are situated a 150m from the town beach,200m from the town centre,100m from the bus stop to the port or to other places,about 500m from the harbour,50m from the super market and the... Więcej...
Zeus Hotel
One of the most beautiful in Greece, Naxos Island blends gorgeous golden sand beaches with majestic mountains. The spacious beaches open to shallow waters ideal for families with children. Adult guest... Więcej...
Hotel REA is a friendly family run hotel, located only 150 meters from the sandy beach of Saint George and 300 meters from the centre of the town of Naxos island. It is surrounded amongst others by su... Więcej...
Depis Place
Welcome to Depi's Place in Naxos Island!
Welcome to Studio Depis Place, which consists of 6 double and 3 triple rooms, each are fully equipped and offer all amenities to make your stay enjoyable an... Więcej...
Pension Sofi
Pension Sofi has been recommended by the A'travellers guide books Lonely Planet 'Europe and Western Europe', Rough Guide, Kykladen and O-luffa i Greekland.
Pension Sofi is situated in the most pict... Więcej...
Anixis Resort
Our family business Hotel is situated just 50 meters from Saint George Beach and 150 meters from the city center.
Our spacious and comfortable rooms have a small kitchen , private balcony & b... Więcej...
Hotel Galini
FREE Wi Fi INTERNET
In Naxos Island, only 30 metres from the beautiful beach of Saint George and at a very convenient point, Hotel Galini is one of the most... Więcej...
Ocean View Hotel
The hotel is 800 meters from the port on Grotta Hill. It is a very quiet area with views of the old town and the port and the town.
The hotel has 17 rooms and the reception is open 24 hours a day.... Więcej...
Studios Rea sun is located in a beautiful quiet area,just only 50 meters from the beautiful sandy beach of St. George and 300 meters from the center the town of Naxos.
REA SUN STUDIOS offers serv... Więcej...
Klimataria Studios
Just 50 meters from Klimataria studios you will find the stunning beach of Agios Prokopios.
Klimataria Studios in Agios Prokopios Naxos is comprised of 6 spacious and elegantly furnished apartments... Więcej...
Mavromatis Studios
Mavrommatis Studios is a family run complex located in Naxos town at the southern part of Saint George Bay (Flisvos Area), only 200 metres from the sandy beach.
It offers easy access to anywhere (b... Więcej...
Golden Beach Studios
Golden Beach consists of 12 studios in original Cycladic style, located in a peaceful and relaxing corner of the most unique Greek island. 5 minutes from Saint George Beach and 3 minutes from Naxos To... Więcej...
Dinanaxos Studios
The apartment are situated in quiet surroundings with only a few minutes walk to the beach and the small city of Agios Prokopios where you will find restaurants, bars, car/scooter rental, money exchan... Więcej...
Hotel Delfini offers air-conditioned accommodations with T.V, hair dryers and complimentary toiletries. This Naxos hotel provides complimentary wireless high-speed Internet access. Bathrooms includ... Więcej...
Ammoudia Studios
The complex ammoudia studios, with newly built rooms and apartments waiting for you to relax and enjoy the beauty of the landscape that nature generously offers to visitors. Rooms with unique views of... Więcej...
Zefyros Studios
Naxos is one of the biggest island in cyclades. In this breathtaking island you will find Zefyros Studios, in between rocky hills and the sandy beach of Plaka, one of the most beautiful beaches of Nax... Więcej...
Birikos Hotel
Birikos Hotel in Agios Prokopios - naxos ,welcomes you to one of the finest beaches of Greece, Agios Prokopios beach in Naxos Island.
Birikos Hotel in Agios Prokopios is a family-run business, foun... Więcej...
Mobilna aplikacja Hostelworld
Rezerwuj w dowolnym miejscu i czasie korzystając z nowej aplikacji mobilnej Hostelworld


text:
Science education group retools
Society aims to get kids into careers
After years of decline, Engineers & Scientists of Milwaukee was an organization in need of re-engineering.
Membership in the 104-year-old society had fallen to about 300 from a peak of about 1,800 in the late 1960s.
Remnants of headier days lived on in events like the group's Rube Goldberg Machine Contest and its sySTEM Now! Conference, but it clearly needed an overhaul.
A year ago, sparked by three boosters from academia and industry, that process began.
The result is a revitalized organization with a new mission and a new director.
At the core of the mission is an initiative called STEM7.
The STEM stands for science, technology, engineering and math, and the initiative's reach is every budding technologist in the seven-county Milwaukee area.
So far, STEM7 has raised $250,000 in operating funds from a dozen companies, foundations and government, said Van Walling, the engineer in charge.
STEM7 has helped Milwaukee Public Schools build a pre-engineering program that the district says has more participants than any other school district in the country. It has helped get the National Society of Black Engineers to hold its 2013 conference in Milwaukee, and it worked with the state Department of Transportation to organize a first-ever Wisconsin Transpo Expo that will expose middle-school students to transportation and technical career opportunities.
The group's goal is to jump-start talent at every high school, middle school and grade school in the region, said Walling, who has been working as full-time executive director of Engineers & Scientists of Milwaukee since September.
STEM7 is collaborating with existing programs along with educators, industry and politicians.
"We are passionate about trying to make these things happen," said Stan Jaskolski, dean of Marquette University's engineering school.
Jaskolski; Mary Lou Young, Rockwell Automation's director of global community relations; and Bill Berezowitz, GE Healthcare's vice president, started the STEM7 initiative by approaching Engineers & Scientists of Milwaukee.
They pulled in Walling, a civil engineer who was active in STEM-related activities. Walling had been trying for several years to figure out how to better coordinate STEM marketing and education efforts. That made him a natural to lead the effort, Young said.
"Van has this great mix with both his business background and credentials, which are stellar, and his business acumen, which is helpful organizationally. But the guy's also got a killer amount of passion for it," said Lauren Baker, coordinator for career and technical education for MPS.
About 10% of all MPS students in grades six through 12 participate in Project Lead the Way classes, which are developed by a national nonprofit organization that promotes pre-engineering courses, Baker said. That's the highest penetration rate of any school district in the country, she said.
Key to MPS' success in driving STEM education is the involvement of 40 corporate partners, Baker said, and Walling was always one of the most active.
Walling has visited what he views as the best models for STEM education in Denver, Kansas City, Mo., and Ohio. He said he came away impressed with their funding, but confident that the public/private partnership STEM7 is building will serve this area well.
"Granted, it's early and we're in the framework-building phase, but what we're putting in place I think girds us for long-term success," said Walling, who still does special assignments for his former employer, CH2M Hill.
Walling says he'll measure that success in a variety of ways, including how many more students in sixth through 12th grades are choosing programming in their schools that stress technology and math.
His advisory board - Berezowitz, Jaskolski and Young - would like to see so many kids choosing technical careers that it catapults Engineers & Scientists of Milwaukee back to the membership levels it had in its heyday, when Milwaukee was a technology hotspot.
"This isn't about competition," Young said. "This is about building a talent pool so strong that we almost don't have to compete."
Here's a list of places that offer science, technology, engineering and math, or STEM, programs in summer camps.
Camp Invention, kids entering grades one through six, (262) 781-6988
Discovery World Summer Camp, ages 7 to 14, (414) 765-8625
Engineers & Scientists of Milwaukee Website Design Camp, MPS middle-school students, (414) 383-2834
4-H Gateway Academies, kids entering seventh, eighth or ninth grade, (414) 256-4626
Marquette University Engineering Education Outreach Programs, ages 6 to 18, (414) 288-6720
MSOE Summer Camps, fifth- through seventh-graders, (414) 840-1238; and high school sophomores through seniors, (414)277-7207
Sally Ride Academy for Kids, kids entering second through ninth grades, email@example.com
Urban Ecology Center, age 3 through eighth grade, (414) 964-8505, Ext. 125.
UWM College for Kids, kindergarten through age 17, (414) 227-3360
Source: Scientists & Engineers of Milwaukee and other organizations
Business Wire
Recent national business updates from the Associated Press


text:
Recovery Act pushes transition to electronic medical records
Recovery Act incentives help push transition to electronic medical records
Hospitals and doctors were given a mix of incentives and penalties in last year's Recovery Act to speed the move from paper to electronic health records.
The incentives, and the prospect of penalties, may be working.
Health care systems throughout Wisconsin are scrambling to meet requirements that would entitle them to tens of millions of dollars in additional payments from Medicare and Medicaid.
Nearly all of the health systems in the Milwaukee area expect to qualify for the initial payments available to hospitals in the first stage. But it is going to take some work.
"This is not meant to be easy, and it certainly isn't," said Joe Kachelski, vice president of the Wisconsin Hospital Association.
Smaller hospitals throughout the state as well as physician practices - including those that are part of a health system - may have a harder time qualifying for the initial incentives available next year. But the incentives clearly are spurring hospitals and doctors to make the difficult and costly transition to electronic records.
"Years from now, the country could look back on this as a turning point," said Sam Butler, a physician with Epic Systems Corp. Epic, which employs roughly 4,000 people in Verona, is one of the largest companies selling software for electronic health records.
The American Recovery and Reinvestment Act contains an estimated $27 billion in incentives over six years to spur a final push toward the long-standing goal of moving from paper charts to electronic records.
The transition is widely seen as an essential component in improving and tracking the quality of health care - particularly for coordinating care, managing patients with chronic diseases and lessening the variation in how medicine is practiced.
"We see this as all about delivering standardized, evidence-based, best-practice care," said Philip Loftus, chief information officer of Aurora Health Care.
The electronic systems, which will have to meet strict standards for security, also could give hospitals and doctors easy access to patients' complete medical records. A cardiologist or other specialist, for example, would be able to view a patient's medical record from his or her primary care physician.
The incentives will cover only part of the cost of the transition and are far from guaranteed.
To receive the additional payments, doctors and hospitals must not only have a system for electronic health records in place but also prove that they are making full use of it.
The federal government released the initial requirements for "meaningful use" this summer. They include prescribing drugs electronically, automatically checking for drug interactions and tracking whether patients have been screened for certain diseases.
Hospitals must use a set of 14 core functions, and doctors must use a set of 15 in their systems. They also must show they are using five out of 10 optional functions.
Hospitals and doctors have to show that they used core functions for 90 days before Oct. 1, 2011, to qualify for the first payments. The requirements will get tougher progressively between now and 2015.
Aurora estimates it will have to spend about $20 million to meet the requirements for the first stage. But it estimates that it has spent roughly $150 million on its system so far, excluding the cost of annual maintenance.
"What the government wants is very closely aligned with what we want," Loftus said.
Aurora estimates that seven of its 15 hospitals will meet the requirements immediately. It will have more work to do for its physician practices. But the health system estimates that it could receive $50 million to $100 million in additional payments from the incentives.
Froedtert Health, Wheaton Franciscan Healthcare, Columbia St. Mary's and ProHealth Care also expect their hospitals to qualify for the initial incentive payments.
"On the hospital side, we are in a good position," said Stephen Cardamone, chief medical officer of Wheaton Franciscan.
The health care system could receive tens of millions of dollars in additional payments from the incentives. Wheaton Franciscan, which began its transition in 2006, has spent an estimated $100 million so far at its hospitals and clinics.
Children's Hospital and Health System is not as far along in the move to electronic health records as the other health care systems in the Milwaukee area.
It expects to select a system this year, and the conversion is projected to cost $140 million over three to four years, said spokeswoman Stacey Mueller.
Some won't qualify
For certain, some hospitals and physician practices won't qualify for the incentives. And health care systems that are just starting are unlikely to meet the deadline for the initial incentives.
Hospitals also don't know what the requirements will be in the next two stages.
"These two-year increments are not a lot of time," said Kachelski of the Wisconsin Hospital Association.
He acknowledged that there is general agreement on what the systems should be able to do in the future. But software companies will have to add features to their systems to meet the requirements.
"It's a major undertaking to tinker with these systems," said Matthew Stanford, associate counsel for the Wisconsin Hospital Association.
The move from paper records to electronic health records almost always takes longer than expected. For some hospitals, the incentives will not justify rushing their projects.
"The incentives do help significantly with the cost, but these systems are enormously expensive to install," said Peter Sanderson, a physician and director of medical informatics for Ministry Health Care, which operates 15 hospitals and clinics throughout central and northern Wisconsin.
Ministry is partnering with Marshfield Clinic, one of the pioneers in developing a system for electronic health records, for its clinics and is in the midst of its conversion.
It is anything but easy.
"We've had our successes and our challenges," Sanderson said.
Avoiding penalties
For some hospitals and doctors, the goal may be to avoid the potential penalties: Doctors and hospitals that haven't made the move to electronic health records will receive lower payments from Medicare and Medicaid after 2015.
That said, Wisconsin is farther along than most parts of the country. Nearly all of the state's large hospitals are well on their way to moving to electronic records. This is largely because the state is dominated by large health care systems that employ physicians and have spent heavily to move to electronic records in recent years.
That's not the norm in parts of the country where the majority of doctors work in small practices of two or three physicians. Those practices have largely held off on making the costly and difficult transition.
The electronic systems are estimated to cost $40,000 to $45,000 for each doctor, nurse practitioner or physician assistant in practice, plus $15,000 a year for maintaining the system, said Greg Simmons, president and chief executive MetaStar, which works with Wisconsin hospitals to improve health care quality.
Doctors can receive up to $44,000 in incentives from Medicare and up to $63,750 from Medicaid under the Recovery Act. Patients covered through Medicaid programs, such as BadgerCare Plus, must make up a large percentage of a doctor's practice for him or her to qualify for the incentives.
MetaStar operates the Wisconsin Health Information Technology Extension Center, which has received federal grants to provide technical support to physician practices, community health centers and rural hospitals for the transition.
The center, one of 60 regional extension centers in the country, has received an $828,000 grant to help rural hospitals and a $9.125 million grant to help primary care doctors and other providers with the transition.
Rural hospitals and small, independent physician practices will have a harder time meeting the requirements. But the incentives and potential penalties under the Recovery Act have made clear that they no longer can put off the challenging task of parting with their paper charts.
"If nothing else, it's persuading the providers and practitioners that this isn't going away," Simmons said.
Business Wire
Recent national business updates from the Associated Press


text:
Sales for my web product
This project received 4 bids from talented freelancers with an average bid price of $22 USD / hour.Get free quotes for a project like this
Skills Required
Project Budget$15 - $25 USD / hour
Total Bids4
Project Description
I am in progress of building a website for some targeted customers and I would like to have a salesperson to help me market it.
Looking to make some money?
- Set your budget and the timeframe
- Outline your proposal
- Get paid for your work
Hire Freelancers who also bid on this project
Looking for work?
Work on projects like this and make money from home!Sign Up Now
- Forbes
- The New York Times
- Time
- Wall Street Journal
- Times Online


text:
1-888-732-2348 1-866-383-2766 español View Your Order
for the month of
Cannot be applied to industry discounted prices, previous orders or tests not listed on our website. One coupon code per order. Coupon code expires at Midnight EST.
People who suffer from addiction often have one or more accompanying medical issues, which may include lung or cardiovascular disease, stroke, cancer, and mental disorders.
Some schools, hospitals, and places of employment conduct drug testing. There are a number of ways this can be done, including: pre-employment testing, random testing, reasonable suspicion/cause testing, post-accident testing, return to duty testing, and followup testing.
CDC currently recommends a two-step process when testing blood for evidence of antibodies against the Lyme disease bacteria. Both steps can be done using the same blood sample.


text:
Baby Gifts Coupon Codes Near Me - Baby Gifts Deals
Baby Gifts
If someone you know is pregnant or just had a baby, you've likely got some shopping to do. Diapers, clothing, toiletries and wipes can all come in very handy to new and expectant mothers and you can use coupons for baby gifts, too. Printable coupons for baby gifts are great to keep on hand to be combined with in store deals and sales.
10% Off All Orders
Exclusions apply.
$5 Off Entire Purchase
Flat Rate Shipping for only $4.99
Sign Up for the Corner Stork Newsletters and Receive Latest Updates
Check Out Sale Section for Big Savings
Free Shipping on $75+
Check Out Happy Blankies starting at $12
Check Out Featured Products for Great Deals
Sign Up for rosieMADE Email Newsletters and Receive Exclusive News and Offers
$4.99 Flat Rate 3-Day Shipping!
Sign Up for Dimples Shop Emails and Receive Exclusive News and Offers
Coupons.com Exclusive: Save 15% Off Sitewide
10% Off All Orders
Up to 50% Off Sale Items
Save Up to 50% Off Sale Items
Save Big on Featured Sale Items
Check Out Featured Items for Great Deals!
Free Shipping on $49+
Save Up to 50% Off Select Products
Save Up to 50% Off Sale Items
Save 33% Off Clearance Items
Free Shipping on $100+
20% Off All Orders
Exclusions apply.
Check Out Coupons Section for Huge Savings!
Get 5% Off Your Order with F&F Newsletter Signup!
$5 Shipping for U.S. Orders
Save 5% Off your Next Order when you Refer A Friend
Invite Your Friends on MyRegistry.com for Exclusive Offers and Discounts
Sign Up for Patemm Emails and Receive Special Offers and News
Free Shipping on $75+
$10 Off $59.99 Orders
Enter code at checkout.
Save $10 Off Minimum Purchase
First Time Customers Only, May Only be Used Once Per New User
Save Up to 60% Off Sale Items
Shop Now for Featured Products for Great Deals!
Check Out Memory Miser Products and Offers Today
Summer Sale: 12% Off Sitewide
Sign Up for Box and Wrap Email Newsletters and Receive Exclusive News and Offers
Join Buttercream Club for only $19.99
Check Out Featured Products Today!
Great Deals on Featured Products
Subscribe to Thread Art Newsletter for Exclusive News and Offers
Save Up to 30% Off Sale Items
Free Shipping on $99+
Check Out Featured Items for Great Deals!
Free Shipping on $75+
Check Out Discount Section for Great Offers and Promotions
Free Shipping on $65+
Up to 90% Off Clearance Items
Free Domestic Shipping on $49+
Exclusions apply.


text:
General Message Board
Phoenix points
Well besides all the hype & drama of the closing laps today, the 24's antics did me a big time favor in my points battle in my main league, as my competitor had Logano, which almost made up for me having JJ and him taking KyBusch in the A group. What was looking to be a 125 point loss after the 48 wrecked ended up only being a 31 point loss (and rarely am I as happy to lose by 31 points :-p )
More impressively, despite my 268 for the 48 16 39 43 (18 for qual.) combo, I actually moved up in the season rankings, 54 spots to #2898 :-D
Best possible combo:
18 11
39 5 56 xx
47/93 xx
362 pointsSort: Newest | Oldest | Most Replied Expand all replies
306 points this week. i am already 189 points over 10,000
279 with Sam and Truex, only need 45 points to reach 10,000 points. So worth seeing JJ wreck. Nice job guys. Only one to go.
234 here with Hornish and Logano.
- 1 Reply to Richard
245 looks like we had similar line ups
107 points for me today...Jimmie, Truex, Joey and Sam.
- 1 Reply to Benny
Ouch Benny - my first year (2008) I had a big lead in the only league I was in going into Homestead and someone on this board suggested trying to get the lowest possible score for the finale so I went along with it, along with 3 or 4 others - I remember I picked Kurt Busch for my A guy and he did not disappoint with a 43rd finish, and I don't remember who else for the others (pretty sure Mikey was one of the B guys anyway), plus back then you didn't have the start-n-parks so your C guy had a chance of actually doing halfway decent.
Anyway with that as a lengthy background I believe I got something like a 112 and that was "good" enough to "win" the reverse competition :-p So you did even "better" :'-(
335 for NADS Motorsports...
I only need three of my eight drivers to start at Homestead to score my first ever 10,000+ season!!
- 3 Replies to Da Goat®
Great job Goat!
Congrats Goat!
Expert Fantasy Advice
Ranking Fantasy Hockey's top 50 players in preseason Big Board
The Big Board takes into consideration past returns, current performance and expected future gains in determining who should be included. … More »
Ranking Fantasy Football's top 50 players in Big Board for Week 3
Kelvin Benjamin has hit the ground running in his return from injury, which has him moving up on Brandon Funston's updated rankings. … More »
Outfielder Shuffle Up: The ageless Carlos Beltran
There's plenty wrong with the Yankees offense this year, but Carlos Beltran is part of the solution. … More »
Freak Show Podcast: Cardinals pen, Strasburg and Giolito, Steven Wright
Brandon Funston and Scott Pianowski talk MLB news and happenings, starting in St. Louis. … More »
Daily Dime: Hanley Ramirez, Kershaw and Cueto, Coors Field
Hanley Ramirez's bat has come alive this week and he's cheaply priced for Sunday DFS. … More »


text:
The major signaling pathways regulating gastric stem cells are unknown. Here we report that Notch signaling is essential for homeostasis of LGR5+ antral stem cells. Pathway inhibition reduced proliferation of gastric stem and progenitor cells, while activation increased proliferation. Notch dysregulation also altered differentiation, with inhibition inducing mucous and endocrine cell differentiation while activation reduced differentiation. Analysis of gastric organoids demonstrated that Notch signaling was intrinsic to the epithelium and regulated growth. Furthermore, in vivo Notch manipulation affected the efficiency of organoid initiation from glands and single Lgr5‐GFP stem cells, suggesting regulation of stem cell function. Strikingly, constitutive Notch activation in LGR5+ stem cells induced tissue expansion via antral gland fission. Lineage tracing using a multi‐colored reporter demonstrated that Notch‐activated stem cells rapidly generate monoclonal glands, suggesting a competitive advantage over unmanipulated stem cells. Notch activation was associated with increased mTOR signaling, and mTORC1 inhibition normalized NICD‐induced increases in proliferation and gland fission. Chronic Notch activation induced undifferentiated, hyper‐proliferative polyps, suggesting that aberrant activation of Notch in gastric stem cells may contribute to gastric tumorigenesis.
See also: X Yin & JM Karp (October 2015)
The Notch signaling pathway is required to maintain LGR5+ antral stem cells and epithelial cell homeostasis.
Gastric antral stem cells display active Notch1 receptor signaling.
Global Notch inhibition reduces stem and progenitor cell proliferation and increases differentiation of all lineages.
Notch activation in LGR5+ stem cells increases stem and progenitor cell proliferation and inhibits differentiation.
Notch activation enhances antral stem cell function, leading to tissue expansion via gland fission and tumor formation.
The EMBO Journal (2015) 34: 2522–2536
- Received November 17, 2014.
- Revision received June 30, 2015.
- Accepted July 16, 2015.
- © 2015 The Authors
Subscribers, please sign in with your username and password.
Log in using your username and password
Log in through your institution
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
EMBO Members please login here to access the journals
Subscribe to the Journal
Recommend to your Librarian


text:
Smartphones are also entitled to their entry level models, as evidenced by this little Optimus Me (also called P350) from LG, freshly announced at Mobile World Congress. Under the hood, available in five colors (silver, black, navy blue, pink and red) lies a small processor at 600 MHz that runs Google Android 2.2.
HSDPA (3G +), Wi-Fi 802.11 b, g and n and Bluetooth connectivity is no problem, everything is there. Multimedia side is less Folichon: The camera is a small 3 Megapixel VGA in that film, and screen, although relatively large (7.1 cm diagonal) and capacitive type, shows only 320 x 240 pixels (QVGA) and can not handle 720p HD video (800 x 480 maximum). Nothing to jump up, but it is after all an entry level model.
If the device is not the king of HD was still entitled to a relatively complete equipment with an electronic compass, accelerometer, FM radio RDS, GPS and 2 GB of onboard memory which can be extended to 32 GB via memory card format MicroSD and SDHC.


text:
Skip to main content
Detroit Lakes Online
Woman jumps into Minnesota lake to help save duck hunters in dramatic rescue
Travel alert: Westbound I-94 blocked between Osakis and Alexandria
Frost Advisory: Areas Of Frost May Develop Overnight
Jacob Wetterling memorial: 'Our love for you will never die'
Golf legend Arnold Palmer dies at 87 just before heart surgery
More Topics
Detroit Lakes
Lake Park-Audubon
Detroit Lakes
COLA to host Homecoming games Thursday
Roth, Smith tied heading to Chip-N Club final round
DL swimmers second to Visitation at Otter Invitational
FOOTBALL: Raiders beat up on winless Gators
Johnson's first place finish leads DL boys to second at Milaca Mega Meet
More Topics
College Sports
State Tournaments
Fostering hope: Local woman organizes 'kid kits' fundraiser for county's foster care program
Teaching the 'lost language'; New teacher of the Ojibwe Learning and Native American Culture class is all about the students
Senior year, not so glamorous
Touchdowns and Tailgates
Chivers' exchange vows
More Topics
Friends & Neighbors
BD's Gas and Grub under new ownership
MN gas prices down, Colonial Pipeline leakage in south causing issues
Jack Chivers Realty adds new service branch
Preparing to become a caregiver
Dairy Queen set to move to McKinley Plaza Friday
More Topics
business briefs
employee milestones
money management
It's time to put a stop to bullying
Grand opening celebration for The Barn in NYM set Oct. 1
Tamarac Fall Festival set for Oct. 1; waterfowl themes abound
Four things you can do in DL this week for no cost
Fall officially arrives this Thursday!
More Topics
Ronald R. Aanerud
Larry A. Hanson
Ronald R. Aanerud
Genevieve E. Michaelson
David Melvin Hagen
Stop the lies against Eken
Big garbage, big economy
Refugee community should welcome FBI
Don't blame farmers for dying honeybees
Leaving home--love isn't always spoken
More Topics
Lynn Hummel
Jake Pfeifer
other opinions
A couple of shotgun experts find out what they've been missing in mourning dove hunting
Waterfowl hunting season now open in Minnesota
National tourney shows amazing bass catch in Minnesota
Rarely seen, the tough, wily fisher lives among us
Pheasant numbers up 29 percent over last year
More Topics
Blane Klemek
Brad Laabs
Fired up for hunting season; Local Sportsman's Clubs have their sights set on you
LP-A busts a move: Lake Park-Audubon Elementary receives national 'Active Schools' award
4-H'ers bring home ribbons from the Minnesota State Fair
Cormorant art show winners announced
Pine to Palm
Weather Forecast
February 26, 2010
Editorial: More protection needed for workers in corporate bankruptcies
Cheers to U.S. Sen. Al Franken for supporting legislation to curb abuses that deprive employees and retirees of their earnings and retirement savings when businesses collapse. The "Protecting Employees and Retirees in Business Bankruptcies Act" would make several changes to Chapter...
Detroit Lakes/opinion
February 26, 2010 - 5:02pm
July 17, 2009
Franken staff stops in Detroit Lakes
Although his office isn't quite set up, Sen. Al Franken's staff is already hard at work. On Day 3 of a 66-city tour, one of the three teams of Franken's staff members stopped in Detroit Lakes Thursday to see what is on constituents' minds. In Detroit Lakes, they found topics varying...
Detroit Lakes/News
July 17, 2009 - 6:24pm
July 14, 2009
Franken staff to hold town hall meeting in Detroit Lakes Thursday
In one of his first actions as Minnesota's second Senator, U.S. Sen. Al Franken will take his state office on the road. Franken's staff will hold 66 Open Office Hour sessions across Minnesota over the next three weeks. "I came to Washington to work for the people of Minnesota. I'm...
Detroit Lakes/News
July 14, 2009 - 10:38am
April 17, 2009
Coleman relies on 'equal protection' argument
ST. PAUL - Norm Coleman says a constitutional principle, ensuring all voters are treated equally, drives his continuing U.S. Senate election fight. The former senator said his appeal to the Minnesota Supreme Court about the 2008 election outcome, which he plans to file Monday afternoon...
April 17, 2009 - 3:00pm
April 14, 2009
Franken declared winner - for now
Al Franken won the U.S. Senate race and should be sent to Washington, a Minnesota three-judge panel ruled Monday evening. It still may be months before a new senator is seated, however. Norm Coleman plans to appeal the decision to the state Supreme Court. The loser at that level...
April 14, 2009 - 9:34am
April 7, 2009
Franken takes bigger vote lead in ballot recount
ST. PAUL - Al Franken took a lead of more than 300 votes today as a three-judge panel counted U.S. Senate absentee ballots that had not been...
April 7, 2009 - 1:19pm
Minnesota's contentious, tedious Senate trial could end today
ST. PAUL - What could be the final day of Minnesota's U.S. Senate trial is receiving more attention than it did during seven weeks of testimony. Today's activities drew a packed crowd of reporters, campaign staff, family of court staff and some members of the public into a courtroom...
April 7, 2009 - 11:21am
April 3, 2009
Alexandria voter part of Senate recount saga
ALEXANDRIA - When Ole Nyland of Alexandria voted last fall, he did what he's been doing for the last three or four elections. He got an absentee ballot and visited his wife, Eleanor, at Knute Nelson nursing home. Together, they went through their ballots and decided who to vote...
April 3, 2009 - 3:01pm
April 1, 2009
Senate race heads to high court
ST. PAUL - Norm Coleman will appeal his U.S.
April 1, 2009 - 11:02am
March 31, 2009
In blow to Coleman, court orders just 400 ballots be examined
ST. PAUL - Minnesota's U.S.
March 31, 2009 - 3:06pm
March 7, 2009
Minnesotans tired of Senate race, but know votes count
ST. PAUL - Minnesotans may be sick of hearing about the seemingly never-ending U.S. Senate election, recount and, now, trial, but many say that in the end it may produce more confidence in the electoral system. "It's gotten to the point where even the diehards are burned out," said...
March 7, 2009 - 9:45am
March 6, 2009
Minnesota Supreme Court rejects Franken's demand to be seated immediately
ST. PAUL - The Minnesota Supreme Court today rejected Al Franken's demand to immediately become a U.S. senator. In January, Franken asked the high court to order Gov. Tim Pawlenty and Secretary of State Mark Ritchie to sign an election certificate so he could take office, even while...
March 6, 2009 - 3:12pm
March 4, 2009
Coleman hints at new election
ST. PAUL - Norm Coleman says it may not be possible for the U.S. Senate election trial judges to determine who won the race, adding there is a chance judges might need to order a new election. There are more "illegal" votes in the tally than the 225 votes that separate him from Al...
March 4, 2009 - 9:00am
March 3, 2009
Franken looks to protect his victory as his case starts in election lawsuit
ST. PAUL - Now it is Al Franken's turn. Franken's campaign starts its case in Norm Coleman's U.S. Senate election lawsuit today. The Democrat...
March 3, 2009 - 6:00am
March 2, 2009
Senate election trial judges reject city official's request for more money to testify
ST. PAUL - The U.S. Senate election trial judges rejected a Duluth city official's request for more money in return for his trial testimony. The three-judge panel this afternoon ruled that Duluth Clerk Jeff Cox is not entitled to reimbursement beyond what traditionally is given witnesses. Al...
March 2, 2009 - 3:27pm
Older »


text:
Come out to see our new showroom! We are now located at:
692 Knowles Ave.
The Grange fair was a great success again. We met lots of people and had a great time. Thanks to everyone that stopped by!
We were invited to display at an open house fire prevention night again. It was a great turn out thanks to everyone that came to see us. We had a lot to share with everyone - hopefully this makes for a safer neighborhood! See you there again next year.


text:
FluGen studies show progress toward universal flu vaccine
FluGen Inc., a Madison vaccine and vaccine delivery product company, said it has done studies in animals suggesting a vaccine it has in development could be taken every three to five years and protect against a wide range of flu viruses - even those it was not designed to prevent.
FluGen presented the data at the World Health Organization influenza vaccine meeting in Hong Kong in January. Current flu vaccines are about 59% effective in healthy people and even less effective in adults over 65 and children under 2, the company said. »Read Full Article(1)
Bemis Co. raises quarterly dividend by 4%
Bemis Co., the Neenah maker of packaging and pressure-sensitive materials, said Thursday its board has approved a 4% increase in the quarterly cash dividend, to 26 cents a share from 25 cents.
The dividend is payable March 1 to shareholders as of Feb. 19. »Read Full Article(2)
ATC pares power line upgrade planned for Upper Peninsula
American Transmission Co. has scaled back the project it proposed last year to resolve power supply challenges in the Upper Peninsula of Michigan.
The maximum price tag of the project now stands at about $400 million, down from nearly $900 million when it was first unveiled. »Read Full Blog Post(1)
Bon-Ton same-store sales slip in January
January sales fell slightly for Bon-Ton Stores Inc., the company said Thursday.
Bon-Ton, which is the parent company of the Boston Store, Younkers and other department stores, said sales at locations open as least a year fell 0.4% in the four weeks ended Jan. 26, compared with the four-week period in January 2012. »Read Full Article(5)
Kohl's same-stores sales rise 13.3% in January
Kohl's Corp. reported Thursday that same-store sales for January increased 13.3%, led by strong sales in the western United States.
The Menomonee Falls department store chain said total sales rose to $1.13 billion from $844 million a year earlier. »Read Full Article(7)
Oconomowoc mayor creates Pabst Farms committee
Oconomowoc Mayor James Daley has appointed three aldermen to a newly created committee to review Pabst Farms development plans, according to LivingLakeCountry.com.
There has been no activity or discussion regarding the proposed Pabst Farms Towne Centre within the last year, says the article, by reporter Paige Brunclik. »Read Full Blog Post(4)
Snap-on Inc. reports 14% increase in quarterly profits
With a boost in sales in its tool division, Snap-on Inc. on Thursday reported a quarterly profit of $84.6 million, or $1.43 per share, up nearly 14% from the same quarter a year ago.
The Kenosha maker of tools and automotive diagnostic equipment said it had $796.1 million in sales in the recent quarter, up 3% from a year earlier. »Read Full Article(1)
Housing considered at former St. Michael Hospital site
Community Care Inc. is considering the development of an assisted living facility for the former St. Michael Hospital site, on Milwaukee's north side.
The facility would be on the north side of W. Villard Ave., generally east of N. 25th St., on the site's northern portion, according to a new proposal filed with the Common Council. »Read Full Blog Post(2)


text:
We found 1 that has recently dropped in price. Sign up to see this price drop and to receive future price drop notifications.
Total Reviews
Sort byMost Recent|
2003 Nissan Murano SL Fwd 4dr SUV (3.5L 6cyl CVT)
After taking the vehicle to both the local Nissan dealership and trusted tranny guy - neither could find any problems.
Yet when the car is warm and you run into stop & go traffic (I live in So. Cal.) which is a regularity,you will experience the lurch/delay.
Luckily no accidents! However, putting it into park and restarting the vehicle seems to "reboot" the problem and it will be okay for a while & then resurface when you least expect it.
It is a fun comfortable car to drive. However, I don't feel safe driving it more recently and am looking for another vehicle.
The 2003 Murano has a transmission problem and after reading multiple sites, it is one that Nissan should address.
2003 Nissan Murano SL Fwd 4dr SUV (3.5L 6cyl CVT)
Owned 7 years with 50k mi. Still looks good compared to newer cars. Only problems have been gas cap actuator, driver power window motor, garage door opener in rear view mirror and intermittent hesitation problem during stop/start. After dealer performed last recall to replace intake fasteners hesitation problem was cured. Glad it was not transmission. I believe someone posted that Nissan extended the CVT transmission warranty to 10yrs/100k mi. Overall it has gotten me from A to B without any problems but I would have not expected to have these little things break down with such low miles.
Looks, design, comfort.
Better electrical/mechanical parts
2003 Nissan Murano SL Fwd 4dr SUV (3.5L 6cyl CVT)
Hi, I bought this car Brand new few days after came out in the market it was a WOW everywhere. I had some problems but thanks God I got the extended warranty when I first bought. biggest problem is LOSS of Power when taking off or accelerating I told the dealer few times but couldn't find the problem, I took it to another dealer they change the o2 sensor and the catalytic converter. all was under warranty it ran me another 20000 miles but now I am facing the same problem. OIL LEAK from the engine, rattling noises from parts inside cabin. cup holders are easy broken. changed visor clips 3 times, change pedal distance adjuster under warranty. cheap leather cracked everywhere
nice looking, sleek design, a lot of room, nice features,
leather, rattling noises , plastics inside cabin are too loose and easy to break,
2003 Nissan Murano SL Fwd 4dr SUV (3.5L 6cyl CVT)
I was initially lured by the Murano's design, then fell in love with how it drove. I bought it new in January 2004 and have never regretted it. 170,000 miles later I am still impressed with it's reliability and build. I have only paid for routine maintenance, and continue to enjoy consistent performance. No issues with things falling apart or breaking. Friends comment that it is still "like new". Either I got lucky with a perfect car, or the Murano is just close to perfect.
Comfortable and roomy seating. Great sound system. Cavernous hauler when back seats are folded down.
2003 Nissan Murano SL Fwd 4dr SUV (3.5L 6cyl CVT)
I have a 2003 that had 20k when I got it in 2007. The entire fuel system failed in my car at 40k in Oct. 2008. I liked the car for some of the + points, but this car has just become worse over time. The driver side visor broke and Nissan wants $350 to fix it, but their own parts employee said that they see this problem all the time/everyday! The car has just under 50k on it, and I think that a problem with the transmission is starting because it loses power from the get go when at a stop. I don't know why Nissan was so shoddy making this car b/c it was suppose to be a unique, sleek SUV.
The color, style, power, and the Bose sound system
The visor, my Bose speaker is already broken on the right side, and a whole lotta engine issues.
Help | About Us | Contact Us | Careers | Affiliate Program | Dealer Center | Privacy Statement | Visitor Agreement | Membership Agreement
Your Ad Choices | Site Map | Glossary | Mobile | Developers
Follow Edmunds
© Edmunds.com, Inc.


text:
Below are top resources on SparkPeople for Natural Stevia.
The sweetener stevia has plenty of dedicated followers. Who can blame them? For years, food and supplement manufacturers have advertised stevia as all natural, calorie free and safe for people with diabetes. To many people, stevia seems like a win-wi... Read more
If you're seeking to reduce your caloric intake, then sugar substitutes are worth a look. Sweeteners like sucralose and stevia are 200 to 600 times sweeter than granulated cane sugar, and they contain 0 to 5 calories per 1 g serving. When used... Read more
Do you feel like you are surrounded by sweets? Cookies, ice-cream, candy, soda and other sugary treats are everywhere, along with the extra calories and simple carbohydrates they contain. For people with diabetes and those trying to cut calories and... Read more
Surely you've heard the old saying, "an apple a day keeps the doctor away." While a daily apple is a better strategy than nothing, it'll actually take a much stronger plan to really boost your immune system. Almost every year,... Read more
Many of the same wholesome foods that you eat to help you glow from the inside-out can also be used externally, as shampoos, conditioners and hair masks. These vitamins, minerals, and oils that nourish your body also nourish your hair. Below you&rsqu... Read more
Anyone have a good natural cold remedy?... Read more
Does anyone know a natural way/remedies to boost your metabolism?... Read more
Hi! I started looking for healthier recipes a few months ago- lot of ideas of what constitutes healthy. A lot of them call for agave or stevia as an alternative sweetener to sugar; but I have also read there are health benefits of honey for adults.... Read more
So what's better sugar free or less natural sugar?... Read more
Does anyone know natural ways to balance hormones? I've tried estroven and other supplements with no luck. Also tried hrt. It caused major problems.... Read more
Stevia has natural ingredients with no known side effects, no calories, no carbs, no fat, no affect on glucose levels & no sugar & no artificial sweeteners, It can be advantageous in the prevention &treatment of diabetes & obesity . Use just a little... Read more
I'M LEARNING THAT I CAN REDUCE MY CALS INTAKE MUCH MORE WHEN I USE FF PRODUCTS LIKE MAYO SALAD DRESSING,MILK AND LITE BREADS NEARLY HALF THE CALS YOU JUST HAVE TO KNOW WHERE TO LOOK NOT BAD TASTING EITHER4... Read more
Arkansans encouraging and supporting one another in our effort to lead a healthier lifestyle through fitness and nutrition. Welcome to the Natural State.... Read more
We spent plenty of time this week surfing the web for the most interesting, entertaining and educational stories. From oatmeal to stevia, avocados to packaged foods, this week's links are heavy on the food. Find out which links caught our attention t... Read more
In the last few days before the administration changes hands, the FDA has been hard at work making changes. Here are two of the most interesting rulings: FDA Says Diet Coke Plus Mislabeled In 2007, Coke started selling Diet Coke Plus, also called Co... Read more


text:
Are you M Lessard?Claim your profile
Publications (52)
- [Show abstract] [Hide abstract] ABSTRACT: It is generally accepted that the short arm of chromosome 6 is a likely site to be involved in chromosomal rearrangements of MDS/ANLL following radio/chemotherapy. We report here two cases of t(3;6)(p14;p22). One patient is a 55 years old male with a previous history of occupational exposure who developed, an acute megakaryoblastic leukemia after a preleukemic phase. Chromosome analysis showed a t(3;6)(p14;p22), associated with del (5)(q14q31), –7, with variations and a trend to hypoploidy. The second patient is a 33 years old man, with chronic myeloid leukemia treated with Hydroxyurea (HU), HU + $aL-IFN and $aL-IFN alone. The first cytogenetic study before treatment, showed a t(9;22)(q34;q11). In the following months the patient had simultaneously t(9;22)(q34;q11) + t(3;6)(p14;p22) in a minority and thereafter in all the mitoses, with progressive deterioration, megakaryocyte abnormalities, but no blast crisis. Our patients are compared with the only 5 other published cases with t(3;6)(p14;p22), who shared some common features, namely a past history of chemo/radiotherapy or exposure to chemical mutagens and an association with other, so-called "secondary" chromosome aberrations, on segments 3p, 5q, 7q, 12p and 17p. We suggest that this uncommon translocation t(3;6) is nonrandom. It is worth noting that band 6p21 is the site of pim 1 oncogen, and that a fragile site is located on band 3p14.
Article: Genome profiling of acute myelomonocytic leukemia: Alteration of the MYB locus in MYST3-linked cases[Show abstract] [Hide abstract] ABSTRACT: The t(8;16)(p11;p13) is a rare translocation involved in de novo and therapy-related myelomonocytic and monocytic acute leukemia. It fuses two genes encoding histone acetyltransferases (HATs), MYST3 located at 8p11 to CREBBP located at 16p13. Variant translocations involve other HAT-encoding genes such as EP300, MYST4, NCOA2 or NCOA3. MYST3-linked acute myeloid leukemias (AMLs) share specific clinical and biological features and a poor prognosis. Because of its rarity, the molecular biology of MYST3-linked AMLs remains poorly understood. We have established the genome and gene expression profiles of a multicentric series of 61 M4/M5 AMLs including 18 MYST3-linked AMLs by using array comparative genome hybridization (aCGH) (n=52) and DNA microarrays (n=44), respectively. We show that M4/5 AMLs have a variety of rare genomic alterations. One alteration, a gain of the MYB locus, was found recurrently and only in the MYST3-linked AMLs (7/18 vs 0/34). MYST3-AMLs have also a specific a gene expression profile, which includes overexpression of MYB, CD4 and HOXA genes. These features, reminiscent of T-cell acute lymphoid leukemia (ALL), suggest the targeting of a common T-myeloid progenitor.
- [Show abstract] [Hide abstract] ABSTRACT: The t(1; 19)(q23;p13) translocation occurs commonly in B-lineage ALL. Previous reports have demonstrated a predominance of cases with expression of cytoplasmic Igμ (Cμ+), an FAB L1/L2 phenotype, a poor prognosis and expression of a fusion transcript involving the E2A and PBX1 genes in Cμ+ but not in Cμ- cases. Of 38 patients with karyotypically proven t(1;19) (q23;p13) leukaemias, we extensively analysed 18 patients with acute leukaemia including 16 B-lineage ALLs, one T-ALL and one AML M4. The AML was associated with a classic E2A-PBX1 fusion transcript and may represent the human counterpart of the AMLs induced by E2A-PBX1 retroviral infection of murine marrow progenitors. The T-ALL was E2A-PBX1 negative and neither the E2A nor the LYL-1 genes, both situated at chromosome 19 p13, were rearranged. Of the 16 B-lineage ALLs, four had cytological features resembling an 'L3-like'phenotype classically associated with Burkitt's lymphoma, two at diagnosis and relapse and two exclusively at relapse. E2A-PBX1 fusion transcripts were detected by RT-PCR in all 13 Cμ+ patients and in 2/3 Cμ- cases. The 'L3-like'phenotype did not correlate with a particular stage of maturation arrest (one sIg+, one Cμ+, one Cμ-) or type of E2A-PBX1 transcript, but was associated in all cases with a trisomy 8. Translocation, rearrangement, amplification or over-expression of the c-myc gene was not observed in these cases, demonstrating that the apparent association with trisomy 8 is not due to deregulation of this gene. We therefore show that the E2A-PBX1 transcript. although occurring predominantly in Cμ+ pre-B ALL, also occurs in Cμ- early pre-B ALL, sIg+ B-ALL and even in AML. These results suggest that the stage of maturation arrest, and indirectly the prognosis, are not soiely due to the type of fusion transcript associated with the t(1;19).
Article: Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: An integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique[Show abstract] [Hide abstract] ABSTRACT: Thirty cases of acute myeloid leukaemia (AML) with MYST histone acetyltransferase 3 (MYST3) rearrangement were collected in a retrospective study from 14 centres in France and Belgium. The mean age at diagnosis was 59.4 years and 67% of the patients were females. Most cases (77%) were secondary to solid cancer (57%), haematological malignancy (35%) or both (8%), and appeared 25 months after the primary disease. Clinically, cutaneous localization and disseminated intravascular coagulation were present in 30 and 40% of the cases, respectively. AMLs were myelomonocytic (7%) or monocytic (93%), with erythrophagocytosis (75%) and cytoplasmic vacuoles (75%). Immunophenotype showed no particularity compared with monocytic leukaemia without MYST3 abnormality. Twenty-eight cases carried t(8;16)(p11;p13) with MYST3-CREBBP fusion, one case carried a variant t(8;22)(p11;q13) and one case carried a t(8;19)(p11;q13). Type I (MYST3 exon 16-CREBBP exon 3) was the most frequent MYST3-CREBBP fusion transcript (65%). MYST3 rearrangement was associated with a poor prognosis, as 50% of patients deceased during the first 10 months. All those particular clinical, cytologic, cytogenetic, molecular and prognostic characteristics of AML with MYST3 rearrangement may have allowed an individualization into the World Health Organization classification.
- [Show abstract] [Hide abstract] ABSTRACT: The ETV6/GOT1 fusion, resulting from t(10;12) (q24;p13), has been recently described in a myelodysplastic syndrome. We reported a second case of t(10;12)-positive myelodysplastic syndrome in whom fluorescent in situ hybridization confirmed the non-random translocation but molecular biology analyses revealed a ETV6/GOT1 chimera varying from the first case described.
Article: Trisomy 8q due to i(8q) or der(8) t(8;8) is a frequent lesion in T-prolymphocytic leukaemia: four new cases and a review of the literature[Show abstract] [Hide abstract] ABSTRACT: Cytogenetic abnormalities found in four cases of T-cell prolymphocytic leukaemia (T-PLL) are described. An isochromosome 8q was found in three patients and a t(8;8) in one. In the four cases, karyotypes were complex and showed a high degree of instability. In addition, we reviewed 27 published cases of cytogenetically studied T-PLL. On the whole, the most frequently recurring anomalies in T-PLL are 14q lesions with nonrandom breakpoints, inversion (14)(q11q32) or tandem translocations (14;14) (not seen in any of our cases) and trisomy for 8q, mainly due to i(8q), found in more than 40% of patients each. Similar structural anomalies were found almost as frequently among the 23 cytogenetically studied cases of so-called T-chronic lymphocytic leukaemia (T-CLL) reported prior to 1989. It is now accepted that the T-cell counterpart of B-CLL either does not exist or is exceedingly rare and thus previously reported cases of T-CLL sharing the chromosomal characteristics of T-PLL may well have been misdiagnosed examples of T-PLL. Isochromosomes 8q are exceptionally found in other types of haematological malignancies. However, i(8q) could not be shown to be the primary lesion in any case in T-PLL and the role of trisomy for 8q, as well of the associated monosomy 8p, is entirely unknown.
Article: ETV6-NCOA2: A Novel Fusion Gene in Acute Leukemia Associated with Coexpression of T-Lymphoid and Myeloid Markers and Frequent NOTCH1 Mutations[Show abstract] [Hide abstract] ABSTRACT: The ETV6 gene has been reported to be fused to a multitude of partner genes in various hematologic malignancies with 12p13 aberrations. Cytogenetic analysis of six cases of childhood acute lymphoblastic leukemia revealed a novel recurrent t(8;12)(q13;p13), suggesting involvement of ETV6. Fluorescence in situ hybridization was used to confirm the involvement of ETV6 in the t(8;12)(q13;p13) and reverse transcription-PCR was used to identify the ETV6 partner gene. Detailed immunologic characterization was done, and owing to their lineage promiscuity, the leukemic blast cells were analyzed for NOTCH1 mutations. We have identified a novel recurrent t(8;12)(q13;p13), which results in a fusion between the transcriptional repressor ETV6 (TEL) and the transcriptional coactivator NCOA2 (TIF2) in six cases of childhood leukemia expressing both T-lymphoid and myeloid antigens. The ETV6-NCOA2 transcript encodes a chimeric protein that consists of the pointed protein interaction motif of ETV6 that is fused to the COOH terminus of NCOA2, including the cyclic AMP-responsive element binding protein-binding protein (CBP) interaction and the AD2 activation domains. The absence of the reciprocal NCOA2-ETV6 transcript in one of the cases suggests that the ETV6-NCOA2 chimeric protein and not the reciprocal NCOA2-ETV6 is responsible for leukemogenesis. In addition, ETV6-NCOA2 leukemia shows a high frequency of heterozygous activating NOTCH1 mutations, which disrupt the heterodimerization or the PEST domains. The ETV6-NCOA2 fusion may define a novel subgroup of acute leukemia with T-lymphoid and myeloid features, which is associated with a high prevalence of NOTCH1 mutations.
Article: Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2[Show abstract] [Hide abstract] ABSTRACT: Polycythemia vera (PV) is a clonal stem cell disorder characterized by an excessive erythrocyte production. At diagnosis, a normal karyotype is found in < or =80% of cases, but an abnormal karyotype frequently develops with evolution. Trisomy 9 and gains on 9p are some of the most frequent cytogenetic abnormalities, together with trisomy 8 and del(20q) in both PV and idiopathic myelofibrosis. We report the case of a 54-year-old man whose disease was classified as an acute myeloid transformation of PV. Cytogenetic and multicolor fluorescence in situ hybridization (FISH) analysis detected several chromosomal abnormalities that included an amplification of 9p. Complementary FISH analysis established amplification of the 9p22 approximately p24.3 region including several known genes: MLLT3 (alias AF9), JMJD2C (alias GASC1), JAK2, and SMARCA2 (alias BRM). JAK2(V617F) mutation status was quantitatively assessed by allele-specific quantitative polymerase chain reaction. Although crossing points analysis showed JAK2(V617F) mutated alleles at 52%, it is still impossible to describe conclusively the mutational status of the amplified JAK2 gene within the sole homogeneously staining region, because total genomic DNA was extracted for the analysis and not only DNA from cells with the homogeneously staining region. Gains on 9p being among the most common anomalies in PV, amplification of a gene or genes on this region may play a crucial role in the pathogenesis or evolution of PV.
- [Show abstract] [Hide abstract] ABSTRACT: Association of a t(9;22)(q34;q11), BCR/ABL-positive, with a dic(19;21)(p13;p13) has been described in acute lymphoblastic leukemia in relapse, raising the question of whether this association is recurrent. Described here are two cases, one of myeloproliferative disease and one of acute lymphoblastic leukemia, both presenting a masked t(9;22) and t(19;21). Chromosomal rearrangements were ascertained by fluorescence in situ hybridization (FISH) using locus-specific probes, multicolor FISH, and bacterial artificial chromosome array. These additional observations suggest a nonrandom association.
Article: Fluorescence in situ hybridization analysis of 110 hematopoietic disorders with chromosome 5 abnormalities: do de novo and therapy-related myelodysplastic syndrome-acute myeloid leukemia actually differ?[Show abstract] [Hide abstract] ABSTRACT: A retrospective cytogenetic study of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS) was conducted by the Groupe Francophone de Cytogénétique Hématologique (GFCH) to evaluate the structural abnormalities of chromosome 5 associated with other chromosomal abnormalities, in particular of chromosome 7, in these pathologies. In all, 110 cases of AML/MDS were recruited based on the presence of chromosome 5 abnormalities under conventional cytogenetics and supplemented by a systematic fluorescence in situ hybridization study of chromosomes 5 and 7. The abnormalities of the long arm of chromosome 5 (5q) were deletions of various sizes and sometimes cryptic. The 5q abnormalities were associated with translocations in 54% of cases and were simple deletions in 46%. In 68% of cases, 5q deletions were associated with chromosome 7 abnormalities, and 90% of these presented a complex karyotype. Of the 110 patients, 28 had a hematopoietic disorder secondary to chemotherapy, radiotherapy, or both. Among 82 patients with de novo AML/MDS, 63 were older than 60 years. Chromosomal abnormalities often associated hypodiploidy and chromosome 5 and 7 abnormalities in complex karyotypes, features resembling those of secondary hemopathies. Systematic investigation of the exposure to mutagens and oncogenes is thus essential to specify the factors potentially involved in MDS/AML with 5q abnormalities.
Article: Akasaka, T., Balasas, T., Russell, L. J., Sugimoto, K. J., Majid, A., Walewska, R. et al. Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood 109, 3451-3461[Show abstract] [Hide abstract] ABSTRACT: CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid leukemogenesis. Mutations of CEBPA are found in a subset of acute myeloid leukemia (AML) and in some cases of familial AML. Here, using cytogenetics, fluorescence in situ hybridization (FISH), and molecular cloning, we show that 5 CEBP gene family members are targeted by recurrent IGH chromosomal translocations in BCP-ALL. Ten patients with t(8;14)(q11;q32) involved CEBPD on chromosome 8, and 9 patients with t(14;19)(q32;q13) involved CEBPA, while a further patient involved CEBPG, located 71 kb telomeric of CEBPA in chromosome band 19q13; 4 patients with inv(14)(q11q32)/t(14;14)(q11;q32) involved CEBPE and 3 patients with t(14;20)(q32;q13) involved CEBPB. In 16 patients the translocation breakpoints were cloned using long-distance inverse-polymerase chain reaction (LDI-PCR). With the exception of CEBPD breakpoints, which were scattered within a 43-kb region centromeric of CEBPD, translocation breakpoints were clustered immediately 5' or 3' of the involved CEBP gene. Except in 1 patient with t(14;14)(q11;q32), the involved CEBP genes retained germ-line sequences. Quantitative reverse transcription (RT)-PCR showed overexpression of the translocated CEBP gene. Our findings implicate the CEBP gene family as novel oncogenes in BCP-ALL, and suggest opposing functions of CEBP dysregulation in myeloid and lymphoid leukemogenesis.
Article: 13q deletions in B-cell lymphoproliferative disorders: Frequent association with translocation[Show abstract] [Hide abstract] ABSTRACT: The 13q14 deletion is the most frequent abnormality in chronic lymphocytic leukemias/small lymphocytic lymphomas, and this early rearrangement is observed from the start of the disease. The systematic use of a panel of interphase fluorescence in situ hybridization (FISH) may not reveal some probes (targeting chromosomes 11q, 13q, 17p, and chromosome 12) structural abnormalities. In this series, we analyzed metaphases by conventional cytogenetics, followed by interphase and metaphase fluorescence in situ hybridization. We were able to observe 17 cases of 13q translocations with deletions in eight of them. Three distinct regions were involved by translocations in association with or without deletions: a region centromeric to RB1 (13q11 approximately 13), a zone telomeric to D13D25 (13q21 approximately 31), and a 13q14 region deliniated by RB1 and D13S25. In this area, the deletion was variable: RB1 alone (one case), D13S319 approximately D13S25 (five cases), and from RB1 to D13S25 (two cases). The very high frequency of 13q14 loss suggests that these deletions are of pathogenetic importance, but, the importance of the translocations remains to be determined.
Article: [A cytological, immunophenotypical and cytogenetical study of 136 consecutive cases of B-cell chronic lymphoid hemopathies].[Show abstract] [Hide abstract] ABSTRACT: A cytological, immunophenotypical and cytogenetical study of 136 chronic B-cell proliferations (93 CLL, 43 B-cell lymphomas) was led in order to precise diagnosis and to characterize and appreciate chromosomal rearrangements. In this series, mainly selected on blood lymphocytosis criteria, B-CLL were twice more frequent than small B-cell lymphomas. Probes used revealed cryptic abnormalities, which remained unknown by conventional cytogenetics (CC). The frequency of clonal abnormalities (CC and FISH) was 74.8% for this series, with 74.4% for lymphomas and 75.3% for CLL, mainly of Binet stage A (69 A, 13 B, 1 C, 10 unspecified). Proportion was 88.4% in A stages and 84.6% in B stages. In CLL, 13q14 cryptic deletions and translocations were widely majority, 14q32 translocations and trisomy 12 being predominant in lymphoma series. Interphase FISH study of non-clonal metaphasic abnormalities with locus-specific probes often revealed unrecognised clones.
Article: Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: A study of the Groupe Francophone de Cytogénétique Hématologique[Show abstract] [Hide abstract] ABSTRACT: Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRbeta) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute lymphoblastic leukemia (T-ALL) patients leading to transcriptional activation of especially HOXA10. To further address the clinical, immunophenotypical and molecular genetic findings of this chromosomal aberration, we studied 330 additional T-ALLs. This revealed TCRbeta-HOXA rearrangements in five additional patients, which brings the total to 14 cases in 424 patients (3.3%). Real-time quantitative PCR analysis for HOXA10 gene expression was performed in 170 T-ALL patients and detected HOXA10 overexpression in 25.2% of cases including all the cases with a TCRbeta-HOXA rearrangement (8.2%). In contrast, expression of the short HOXA10 transcript, HOXA10b, was almost exclusively found in the TCRbeta-HOXA rearranged cases, suggesting a specific role for the HOXA10b short transcript in TCRbeta-HOXA-mediated oncogenesis. Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL (SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRbeta-HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67%, respectively. In conclusion, this study defines TCRbeta-HOXA rearranged T-ALLs as a distinct cytogenetic subgroup by clinical, immunophenotypical and molecular genetic characteristics.
Article: Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.
Article: HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)[Show abstract] [Hide abstract] ABSTRACT: The t(5;14)(q35;q32) chromosomal translocation is specifically observed in up to 20% of childhood T-cell acute lymphoblastic leukemia (T-ALL). It affects the BCL11B/CTIP2 locus on chromosome 14 and the RANBP17-TLX3/HOX11L2 region on chromosome 5. It leads to ectopic activation of TLX3/HOX11L2. To investigate the reasons of the association between t(5;14) and T-ALL, we isolated the translocation breakpoints in 8 t(5;14) patients. Sequence analyses did not involve recombinase activity in the genesis of the translocation. We used DNAse1 hypersensitive experiments to locate transcriptional regulatory elements downstream of BCL11B. By transient transfection experiments, 2 of the 6 regions demonstrated cis-activation properties in T cells and were also effective on the TLX3 promoter. Our data indicate that the basis of the specific association between t(5;14) and T-ALL lies on the juxtaposition of TLX3 to long-range cis-activating regions active during T-cell differentiation.
Article: Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia[Show abstract] [Hide abstract] ABSTRACT: Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation and indirect and posttranslational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.
Article: Cytogenetic studies of a series of 43 consecutive secondary myelodysplastic syndromes/acute myeloid leukemias: conventional cytogenetics, FISH, and multiplex FISH[Show abstract] [Hide abstract] ABSTRACT: We report a series of 43 consecutive therapy-related myelodysplastic syndromes (t-MDS) or acute myeloid leukemias (t-AML) observed for 6 years. This series consisted of 26 women and 17 men, ages ranging from 9 to 85 years. These cases were classified into three groups according to the primary diagnosis. Conventional cytogenetic and fluorescent in situ hybridization (FISH)/ multiplex FISH (M-FISH) methods were used to analyze cytogenetic characteristics of secondary MDS/AML. The features of chromosomal abnormalities were linked to the nature of the therapy and protocols used. A considerable proportion of recurrent balanced translocations characterized t-AML secondary to therapy. FISH techniques showed that conventional cytogenetics often underestimated associated translocations; some deletions were in fact derivative chromosomes associated with deletions. After treatment for lymphomas and chronic myeloproliferative diseases, there were more complex unbalanced abnormalities than the control group. Compared to other series, recurrent translocations appeared to be more numerous (25%), probably reflecting an evolution of therapeutic modalities.
Article: Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling[Show abstract] [Hide abstract] ABSTRACT: Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. To gain insight into gene expression differences in AMKL, we compared 24 DS and 39 non-DS AMKL samples. We found that non-DS-AMKL samples cluster in two groups, characterized by differences in expression of HOX/TALE family members. Both of these groups are distinct from DS-AMKL, independent of chromosome 21 gene expression. To explore alterations of the GATA1 transcriptome, we used cross-species comparison with genes regulated by GATA1 expression in murine erythroid precursors. Genes repressed after GATA1 induction in the murine system, most notably GATA-2, MYC, and KIT, show increased expression in DS-AMKL, suggesting that GATA1s fail to repress this class of genes. Only a subset of genes that are up-regulated upon GATA1 induction in the murine system show increased expression in DS-AMKL, including GATA1 and BACH1, a probable negative regulator of megakaryocytic differentiation located on chromosome 21. Surprisingly, expression of the chromosome 21 gene RUNX1, a known regulator of megakaryopoiesis, was not elevated in DS-AMKL. Our results identify relevant signatures for distinct AMKL entities and provide insight into gene expression changes associated with these related leukemias. • Down syndrome • GATA1
Article: Berger R, Busson M, Baranger L, Helias C, Lessard M, Dastugue N et al.. Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements. Leukemia 20: 319-321[Show abstract] [Hide abstract] ABSTRACT: The assignment with chromosome banding techniques of the breakpoints of the recurrent translocation t(3;5) which leads to NPM1/MLF1 gene fusion in myeloid malignancies has not been unequivocal. In order to assess whether this is due to uncertainty in interpretation of the observed banding pattern or whether it reflects true genomic heterogeneity, we decided to analyze the breakpoint positions using fluorescence in situ (FISH) techniques in eight patients with myeloid malignancies and rearrangements of chromosomes 3 and 5. In three patients, colocalization of the NPM1 and MLF1 spanning BACs was demonstrated and NPM1/MLF1 fusion shown by PCR in one while in the remaining cases breakpoints were located outside the NPM1 and MLF1 loci. Interestingly, loss of a copy of the NPM1 gene was found in three of these latter patients. This findings suggest that haploinsufficiency of NPM1 may play a role in subtypes of myelodysplasias and leukemias.
Top Journals
CHRU de StrasbourgStrasburg, Alsace, France
Centre Hospitalier Universitaire de PoitiersPoitiers, Poitou-Charentes, France


text:
Supreme Commander: Forged Alliance
Pay for a Trainer
smithnweston posted on Apr 30, 2013 7:41:00 AM - Report post
id be willing to pay 25-50 dollars for CH to make a trainer, 4 or 5 other people willing to chip in for the costs? i think i saw it would take them 3 days to make and about 250 $. post here if your interested
benduhova posted on Apr 30, 2013 3:03:31 PM - Report post
Dude it would be cheaper to ask one of the trainer makers on their sister site I recommend DDS he made a trainer for warlords3 for me when no one else would and it didnt cost the earth
Cheating games not gamers
smithnweston posted on May 01, 2013 7:30:43 AM - Report post
link me the sister site cheers, thanks for the info
benduhova posted on May 01, 2013 3:48:54 PM - Report post
Page 1 of 1
All times are (GMT -06:00) Central Time (US & Canada). Current time is 3:19:11 AM
Latest Trainer
• Instant Build
• Uber Troops
• Increase Actual/Maximum Energy
+ 2 more options
• Uber Troops
• Increase Actual/Maximum Energy
+ 2 more options


text:
Lemmy Didn't Drink Milk, But He Did Make a Weirdly Touching Finnish Milk Commercial
"I don't drink milk. And I never will. You asshole."By Greg Cwik
"I don't drink milk. And I never will. You asshole."By Greg Cwik
So, the people behind Scott Pilgrim, Flight of the Conchords, Sandman, and Mortdecai.By Greg Cwik
In case you are British and need a new milk supplier.By Amanda Dobbins
The gay male characters with more good looks than lines, from the forties through today.By Jay Barmann
Want to lose $10 in your Oscar pool? Bet on these!By Lane Brown
What wisdom do we hope this year's nominees, snubbed hopefuls, and breakout stars take away from one of the most exciting awards races in recent memory?By Mark Graham, Lane Brown and Logan Hill
If you think 'Slumdog' is a lock, think again.By Mark Graham
Are these the front-runners for Best Picture?By Lane Brown
Brolin: 'He just makes me want to be gay.'By Jada Yuan and Bennett Marcus
The Producers Guild just announced their nominees for Best Picture — and they include 'The Dark Knight.'By Lane Brown
We're not really sure we're buying this one.By Mark Graham
'Milk,' Clint, and 'Wall-E,' to name a few.By Lane Brown
The New York Film Critics Circle just named 'Milk' 2008's Best Picture, with prizes for Best Actor and Best Supporting Actor going to Sean Penn and Josh Brolin.By Lane Brown
Says Jeffrey Wells: 'I felt a genuine gayness from Sean Penn that I didn't think he had in him.'By Lane Brown
Plus: Sean Penn and Diego Luna to make out.
Plus the Breeders, John Brolin, and John Turturro in a garbage can.
Plus: News about John Legend!