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Skip to comments.EARTHQUAKES IN THE CENTRAL VIRGINIA SEISMIC ZONE
Posted on 08/23/2011 3:00:46 PM PDT by COBOL2Java
Since at least 1774, people in central Virginia have felt small earthquakes and suffered damage from infrequent larger ones. The largest damaging earthquake (magnitude 4.8) in the seismic zone occurred in 1875. Smaller earthquakes that cause little or no damage are felt each year or two.
Earthquakes in the central and eastern U.S., although less frequent than in the western U.S., are typically felt over a much broader region. East of the Rockies, an earthquake can be felt over an area as much as ten times larger than a similar magnitude earthquake on the west coast. A magnitude 4.0 eastern U.S. earthquake typically can be felt at many places as far as 100 km (60 mi) from where it occurred, and it infrequently causes damage near its source. A magnitude 5.5 eastern U.S. earthquake usually can be felt as far as 500 km (300 mi) from where it occurred, and sometimes causes damage as far away as 40 km (25 mi).
Earthquakes everywhere occur on faults within bedrock, usually miles deep. Most bedrock beneath central Virginia was assembled as continents collided to form a supercontinent about 500-300 million years ago, raising the Appalachian Mountains. Most of the rest of the bedrock formed when the supercontinent rifted apart about 200 million years ago to form what are now the northeastern U.S., the Atlantic Ocean, and Europe.
At well-studied plate boundaries like the San Andreas fault system in California, often scientists can determine the name of the specific fault that is responsible for an earthquake. In contrast, east of the Rocky Mountains this is rarely the case. The Central Virginia seismic zone is far from the nearest plate boundaries, which are in the center of the Atlantic Ocean and in the Caribbean Sea. The seismic zone is laced with known faults but numerous smaller or deeply buried faults remain undetected. Even the known faults are poorly located at earthquake depths. Accordingly, few, if any, earthquakes in the seismic zone can be linked to named faults. It is difficult to determine if a known fault is still active and could slip and cause an earthquake. As in most other areas east of the Rockies, the best guide to earthquake hazards in the seismic zone is the earthquakes themselves.
Earthquake Information for Virginia
Gaia must be very angry at General Motors for not selling enough full-efficient cars. We must make a sacrifice to her. Can anyone suggest someone to through into the pit?
I am just outside of DC, and our office building shook incredibly hard. Some of the damage on the news is right near our building. When the shaking started it was more interesting than scary, but man, once it ramped up after a few seconds it was LOUD and I thought our building was going to collapse.
Inside our office lots of pictures, monitors, books, etc, fell all over the place. Many of my friends and family were in stores and their workplaces and dealt with minor damage as well.
I am still in shock that we actually felt an earthquake that strong here on the East Coast. My understanding is this 5.8 was relatively shallow and created a situation where it felt much more powerful than a 5.8 on the West Coast.
One of my coworkers in NY has been unable to use his cell phone all day.
Not because a cell tower fell, but from all the earthquake newbies calling in a panic!
I must confess, I contributed to the jammed phone lines. I am a true earthquake newbie ;)
I'll tell you though, this thing shook really hard here just outside of DC. It was very loud too. We started coming out of our offices into the lobby and it was almost a novelty at first, but it really ramped up for about 10 seconds and got quite scary. I remember thinking, "oh crap, this building couldn't possibly survive this". I suppose we did exactly what your not supposed to - we took off down the stairs and out of the building.
I will never forget the feeling of that earthquake. Something I see on TV quite often, but never expected to actually experience it myself.
I am guessing Bush's Fault?!
Your very near where I am. I'm working right now in Vienna, VA in a 10 story building. At first I thought the shaking was some sort of building construction, but it started getting louder and more violent and I realized this was something seriously out of the ordinary. We started pouring out of our individual offices into the lobby, and for about 10 - 15 seconds the building shook extremely hard. I know I wasn't the only one that thought the building was going to collapse. Most of us ran down the stairs, and while I realize now it was the wrong thing to do it seemed like everyone was doing the same.
I did not feel an aftershock, but there was a fair bit of damage around us. Watching the news you've probably seen the footage of the townhouses (doctors offices, nail salon, etc) that partially collapsed. That is right near where I was. In fact we walked over and took pictures.
We were all looking at our own building suspiciously now. I assume they will check for structural damage tomorrow.
I am glad you came through it okay. Sounds like other than some minor damage and a rude interruption, you didn't suffer any serious damage. So far, that has also been the case with all of my co-workers, friends and family.
Well who else? The NY Times/CBS just did a snap poll and the results clearly indicate that a majority of Americans believe Bush is responsible for the earthquake ;)
I know it wasn't a huge quake, but I am really surprised there hasn't been more damage. I, too, was a little bit concerned about my building. But mostly, the little kid in just kept saying "this is so cool." What was funny was that right after the quake, people evacuated the building, and were standing right next to the building. I took one look up at all the windows and brick, and decided I liked it better inside.
Yeah, I felt the same way where I was in Vienna. Thing is, right near our building there was a fair amount of damage to that townhouse business complex. Also, calling friends and family that were right near the same area and they reported quite a lot of broken pictures, fallen shelves, knocked over monitors, etc.
What was really odd was I drove home, which is down near Centreville, expecting to see a fair bit of damage at my house and it was as if nothing happened at all. Not even one book, vase, or anything else out of place. I find it really weird because, at least in theory, the Centreville area was closer to the epicenter of the quake. For whatever reason the Vienna (and many other specific areas as I understand it) really got hit hard.
After careful examination and triangulation the Obama Administration just released information the quake originated in the heretofore unreported "Bush's Fault" zone.
On the plus side all D.C. government workers fled their posts so America was saved for another day !
Its reported the President made an emergency cell call to D.C. to see if his favorite pizza parlor survived, and then ordered a "Chicago-style double-cheese, extra sausage" take out to be picked up by Marine One.
In NYC Mayor Bloomberg and Sen. Schumer jointly declared the quake was, "the result a nefarious NRA gun freedom plot".
And on the Left Coast Congresssomething Maxine Waters declared the quake was a "racist TEA Party terrorist plot".
IOW, pretty much another "government as usual" in our fair nation. >PS
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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Two nice ones from the smooth soul team of Grey & Hanks! "Dancin" is an uptempo groover – as you'd guess by the title – but with a smooth sound that keeps the proceedings nice and soulful. "How Can You Life" is a mellower tune – a nice little stepper with a righteous approach that almost reminds us of DJ Rogers! (White label promo.) © 1996-2016, Dusty Groove, Inc.
If something is noteworthy, we try to note it in the comments — especially if it is an oddity that is the only wrong thing about the record. This might include, but isn't limited to, warped records, tracks that skip, cover damage or wear as noted above, or strictly cosmetic flaws.

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Allergies Health Center
Nonallergic Rhinitis
In this article
Nonallergic rhinitis is a medical term that describes a set of symptoms that resemble an allergy but that occur without a known cause. It produces symptoms such as:
- Postnasal drip
- Runny nose
- Sneezing
- Stuffy nose
Usually, it develops in adulthood, and symptoms last year-round.
Recommended Related to Allergies
Tips to Manage Allergies While Traveling
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Read the Tips to Manage Allergies While Traveling article > >
Unlike allergic rhinitis, nonallergic rhinitis does not involve the immune system. About 58 million Americans have allergic rhinitis. By comparison, 19 million have nonallergic rhinitis.
Nonallergic rhinitis can cause just as much misery as allergic rhinitis. It can also be associated with the same complications, such as:
- Sinusitis, which is inflammation or swelling of the tissue that lines the sinuses
- Eustachian tube dysfunction. Eustachian tubes connect the middle ears to the back of the throat
- Chronic ear infection, known as otitis media
- Loss of smell or anosmia
- Asthma
- Obstructive sleep apnea
Both types of rhinitis are associated with:
- Decreased production at work
- Increased doctor visits
- Side effects from treatment, such as drowsiness, nosebleed, and nasal dryness
Because the two are so similar, it's often necessary to perform allergy tests and blood tests to tell them apart.
Causes of Nonallergic Rhinitis
Often, what causes nonallergic rhinitis is unknown. And the condition is often confirmed only after other conditions such as allergic rhinitis or infection are ruled out.
Environmental irritants are common triggers of nonallergic rhinitis. Some are found in the home and others are more common in the workplace.
Examples of what can trigger symptoms include:
- Car exhaust
- Chlorine
- Cigarette smoke
- Cleaning solutions
- Glues
- Hair spray
- Latex
- Laundry detergents
- Metal salts
- Perfume
- Smog
- Wood dust
When such triggers cause nonallergic rhinitis, they also often cause asthma.
Some medications can trigger non-allergic rhinitis. Examples include:
- NSAIDs -- nonsteroidal anti-inflammatory drugs such as aspirin and ibuprofen
- Oral contraceptives
- Blood pressure medicines such as ACE inhibitors and beta-blockers
- Antidepressants
- Tranquilizers
- Drugs used to treat erectile dysfunction
Foods and beverages may also sometimes be triggers. Examples include:
- Hot foods, such as soup
- Spicy foods
- Alcoholic beverages, especially beer and wine
Other triggers include:
- Illegal drugs. Cocaine and other snorted street drugs often cause chronic nonallergic rhinitis.
- Weather changes. Sudden changes in weather or temperature can trigger nonallergic rhinitis. Skiers, for instance, often develop a runny nose. And some people are affected by any cold exposure. In some cases, people even start sneezing after leaving a cold, air-conditioned room.
- Hormone changes. Nonallergic rhinitis often occurs during periods of hormonal imbalance. For instance, it may occur during puberty, menstruation, or pregnancy. It usually starts during the second month of pregnancy and lasts until childbirth. Hormonal conditions such as hypothyroidism can also trigger symptoms.
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Manny Pacquiao's trainer, Freddie Roach, just sat down with reporters in the media room. We asked whether he or Pacquiao was disappointed at all that the Filipino will be fighting Joshua Clottey, and not Floyd Mayweather Jr., on Saturday.
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direct broadcast satellite (DBS)
Direct broadcast satellite (DBS) refers to satellite television (TV) systems in which the subscribers, or end users, receive signals directly from geostationary satellites. Signals are broadcast in digital format at microwave frequencies. DBS is the descendant of direct-to-home (DTH) satellite services.
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A DBS subscriber installation consists of a dish antenna two to three feet (60 to 90 centimeters) in diameter, a conventional TV set, a signal converter placed next to the TV set, and a length of coaxial cable between the dish and the converter. The dish intercepts microwave signals directly from the satellite. The converter produces output that can be viewed on the TV receiver.
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Multiple Dates
New School Leaders Programme: How to Maximise Your Impact in Your First Yea...
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Leading the Organisation
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Celebrating the Journey
Lessons learned; reflection; identifying next steps.


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SEPTEMBER 2016 -- Sept. 10: Installation of Officers, 7:30 P.M. Host: Glastonbury
To view the full article, click here
AUGUST 3, 2016 -- No meeting until September 10, 2016 (because of Labor Day). Hope all are having a marvelous summer and see you in the fall.
JULY 15, 2016 -- No meeting until September. Congratulations to our new officers elected at the last Pomona meeting.
June 3, 2016 -- June 4: Election of Officers, Host Vernon and Stafford Granges
June 18: E. Central Pomona #3 Degree Day, 10 A.M.
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"You have to do your own growing no matter how tall your grandfather was. "
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We do not accept paid editorial content in Business Jet Traveler. This list, like the other directories in our Buyers' Guide, includes a sampling of providers that we consider notable. Our lists are not meant to be comprehensive but we are always open to suggestions for additions.—Jeff Burger, Editor
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Correspondendo a: openstack X
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IBM PowerVC 1.3.1 FP2 now supports Hitachi storage Blog da Comunidade
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利用Packstack在IBM Power LE平台部署OpenStack计算节点 Blog da Comunidade
作 者 :钱韬 领 域:云计算 适宜读者:一年及以上系统软件部署经验 背景知识:Linux基础操作,OpenStack基础知识 前言 OpenStack自2010年问世以来,经过几年的快速发展已成为当今最火热的开源云计算平台之一。每天在OpenStack社区中,大量开发者活跃贡献着,令其功能日益完善丰富;每年两次的OpenStack峰会上,各路专家齐聚一堂分享成果,畅谈业界的未来。OpenStack推动...
do Blog: IBM中国Linux与虚拟化实验室Modificado em por KVMChina
These are not the parameters you're looking for
JohnArwe Marcações: series-juno-cma series-cma zvm series-liberty-cma openstack 687 Visualizações
A quick doorknob post before I disappear into the Wind Rivers for my annual walkabout. (If you find pepper-spray-scented grizzly bear scat with bells in it someday, might be what's left of me ;-) ). It's not easy being smart Sometimes in our...
Liberty fix pack 1 is now orderable
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If you're running xCAT on your z/VM system, you'll want one of the following: VM65834, if you're running CMA Liberty (you have this if VM65780 is applied already and DMSSICMO property openstack_system_role has a non-blank value) VM65833, if...
IBM Storage Driver for OpenStack, version 1.7.0 Blog da Comunidade
DmitriyIsayev Marcações: nova openstack 651 Visualizações
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Implementation of high-resolution SNP arrays in the investigation of fetuses with ultrasound malformations: 5 years of clinical experience
Version of Record online: 31 OCT 2013
DOI: 10.1111/cge.12271
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Clinical Genetics
Volume 86, Issue 3, pages 264–269, September 2014
Additional Information
How to Cite
Liao, C., Fu, F., Li, R., Xie, G.-e., Zhang, Y.-l., Li, J. and Li, D.-z. (2014), Implementation of high-resolution SNP arrays in the investigation of fetuses with ultrasound malformations: 5 years of clinical experience. Clinical Genetics, 86: 264–269. doi: 10.1111/cge.12271
Publication History
- Issue online: 20 AUG 2014
- Version of Record online: 31 OCT 2013
- Accepted manuscript online: 3 SEP 2013 12:49PM EST
- Manuscript Accepted: 30 AUG 2013
- Manuscript Revised: 22 AUG 2013
- Manuscript Received: 24 MAY 2013
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Onycholysis occurs in approximately 30% of patients treated with docetaxel. The efficacy and safety of an Elasto-Gel frozen sock (FS) was investigated for the prevention of docetaxel-induced nail and skin toxicity of the feet.
Onycholysis occurs in approximately 30% of patients treated with docetaxel. The efficacy and safety of an Elasto-Gel frozen sock (FS) was investigated for the prevention of docetaxel-induced nail and skin toxicity of the feet.
Patients receiving docetaxel at a dose of 70 to 100 mg/m2 every 3 weeks were eligible for this matched case-control study. Each patient wore an FS for 90 minutes on the right foot. The unprotected left foot acted as control. Nail and skin toxicities were assessed using National Cancer Institute Common Toxicity Criteria (version 3) and compared using a 2-sample Wilcoxon matched-pairs rank test adjusted for tied values.
Fifty consecutive patients were included between April 2005 and January 2007. Nail toxicity was significantly lower in the FS-protected foot compared with the control foot (grade 0: 100% versus 79%; and grade 1 and 2: 0% versus 21%, respectively) (P = .002). Skin toxicity was grade 0: 98% versus 94%; and grade 1 and 2: 2% versus 6% in the FS-protected and the control feet, respectively. The median times until toxicity occurrence were not found to differ significantly between the groups. One patient experienced discomfort because of cold intolerance.
Cold therapy using FS significantly reduced the incidence of docetaxel-induced foot nail toxicity, as previously demonstrated using frozen gloves for the hands. Cancer 2008. © 2008 American Cancer Society.
The taxanes (docetaxel and paclitaxel), have emerged as among the most powerful classes of cytotoxic agents, exhibiting a wide spectrum of activity against solid tumors including breast, ovarian, lung, head and neck, stomach, and prostate cancer.1 Taxanes have a predictable and manageable toxicity profile. Specific toxicities include asthenia, alopecia, cutaneous reactions, stomatitis, fluid retention syndrome for docetaxel, and neuropathy, myalgia, and arthralgia for paclitaxel.2–5 Myelosuppression and hypersensitivity reactions are common for both drugs. Cutaneous toxicity reported with docetaxel treatment manifested as erythema and desquamation of the skin of the extremities (hand and foot syndrome) and nail changes.6–8 Although hand and foot syndrome does not appear to be a common adverse event with docetaxel treatment,6 nail changes were more often described with docetaxel than with paclitaxel, with an overall incidence of approximately 30%.7 In a recent study performed in 55 metastatic breast cancer patients treated with docetaxel, the incidence of nail toxicity reached 58% after 4 cycles, with an increase to 88% after 3 additional cycles.9 A large proportion of patients experienced the nail changes as a cosmetic nuisance, and >32% had functional problems.9
Nail changes include hyperpigmentation, splinter hemorrhage, subungual hematoma or/and hyperkeratosis, orange discoloration, Beau-Reil lines (indicating the cessation of nail growth), acute paronychia, and onycholysis (the loosening or separation of a fingernail or toenail from its bed).10 These abnormalities are in most cases not serious, but hemorrhagic onycholysis and subungual abscesses can occur, producing important morbidity. These side effects can cause potentially severe complications because patients may become neutropenic during chemotherapy, enhancing the risk of sepsis. Functional disturbance can also occur, leading to patients withdrawing from treatment. The type of nail changes is related to the number of cycles of chemotherapy, and to our knowledge to date few preventive measures are available.11 Topic antibiotics or antifungal agents may be required to treat nail bed infections, which appear to be a complication after the nail's detachment.
In a previous study, we reported that the use of an Elasto-Gel frozen glove (−25 to −30°C) significantly reduced the incidence of nail and skin toxicity of the hands induced by docetaxel administered at a dose of 75 mg/m2 every 3 weeks, either alone or in combination.12 The application of frozen gloves significantly decreased the overall occurrence of nail toxicity from 51% to 11%, with onycholysis occurring in none of the protected hands compared with 22% in the control hand. Skin toxicity was observed in 24% versus 53% of patients (protected vs unprotected hand), respectively.12 These favorable results warrant additional studies to confirm the efficacy of cold protection in preventing nail and/or cutaneous toxicities related to docetaxel.
To our knowledge, there are no data regarding the incidence of specific docetaxel-induced toxicity to the foot. The current matched, case-control, phase 2 study was designed to assess the efficacy and safety of cold therapy in the prevention of docetaxel-induced onycholysis and skin toxicity of the foot. Each patient wore a protective frozen sock (FS) on the right foot and had no protection on the contralateral foot, which was considered the control side. Using this method, it was possible to obtain a comparative incidence of nail and skin disorders with or without cold protection.
Patients enrolled in this prospective study were undergoing treatment for a variety of tumor types with docetaxel administered at doses of between 70 mg/m2 and 100 mg/m2 as a 1-hour intravenous infusion every 3 weeks, either alone or in combination with other cytotoxic agents. Inclusion criteria were as follows: no prior treatment with taxanes, the absence of skin and nail disorders at the initiation of chemotherapy, a life expectancy of at least 3 months, and an Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤2. Patients were excluded if they had Raynaud syndrome, distal bone or cutaneous metastases, ungual pathology, arteriopathy, cold intolerance, or peripheral neuropathy (grade ≥2). All patients provided written informed consent before inclusion. The study was approved by an external Ethics Committee and was declared to the French National Health Agency.
Patients wore an Elasto-Gel (Akromed, France) flexible FS. This patented sock contains glycerin, which has thermal properties that allow its use in hot or cold therapies (Figure 1). The gel-filled sock covers the foot to the ankle. Before use it was refrigerated for at least 3 hours at −25°C to −30°C. For each docetaxel infusion, the patient wore an FS for a total of 90 minutes on the right foot (15 minutes before the administration of docetaxel, during the 1-hour docetaxel infusion, and 15 minutes after the end of the infusion). The study was not blinded. Two FS were used successively (for 45 minutes each) to maintain a consistently low temperature of the foot. The left foot was not protected by the FS and acted as the control.
Onycholysis and skin toxicity were assessed before each cycle of chemotherapy by the investigator (F.S. or E.L.), and double-checked by a second observer (a research nurse), using the National Cancer Institute Common Toxicity Criteria (NCI-CTC, version 3). The NCI-CTC nail and skin toxicities criteria were updated in the most recent version, the third one.13 The nail disorder categories were expanded into 3 grades, similar to that noted in hand and foot syndrome: grade 1, discoloration, ridging (koilonychia), or pitting; grade 2, partial loss of nail(s) (onycholysis) or pain in nail beds not interfering with function; and grade 3, partial loss of nail(s) (onycholysis) or pain in nail beds interfering with function, or complete loss of nail(s). Patient comfort was assessed using a 4-point rating scale that determined whether patients were: dissatisfied (0), not satisfied (1), satisfied (2), or very satisfied (3). The use of the FS was prematurely stopped when patients experienced cold intolerance, had a serious adverse event, or withdrew consent.
The primary endpoint was the efficacy in preventing nail toxicity, and secondary endpoints were the assessment of efficacy in the prevention of skin toxicity, time to occurrence of nail and skin toxicities, and patient comfort. Analyses of toxicities were performed on the per-protocol population defined as the totality of included patients, which used the FS at least 1 time at the first cycle. The 2-sample Wilcoxon matched-pairs rank test adjusted for tied values was used as the main method to determine the statistical significance of difference between the incidence of nail and skin toxicities between FS-protected and unprotected feet. Because time-to-event endpoints were used, Kaplan-Meier and log-rank methods were used to estimate and compare differences in time to toxicity occurrence. Patients were censored if no toxicity occurred at the end of chemotherapy or during follow-up. The impact on the time to nail toxicity occurrence of some confounders such as the ECOG PS, sex, number of cycles, and dose of docetaxel was studied using multivariate Cox regression analysis (forward stepwise selection). Hazard ratios (HRs) were estimated with 95% confidence intervals (95% CIs). Medians with range and frequency percentages were estimated for quantitative and categoric variables, respectively. No adjustment for multiplicity of tests was performed. Subgroup analyses were performed according to the docetaxel dosing schedule: ≤75 mg/m2 and >75 mg/m2. The relational database was created using FileMaker Pro 8.5 (vesion 2; Santa Clara, Calif) software. The statistical analysis was performed using SPSS 15 software (SPSS Inc, Chicago, Ill) and Epi Info (version 3.2.2; Centers for Disease Control and Prevention, Atlanta, Ga).
Fifty consecutive patients were enrolled in a single French center between April 2005 and January 2007. One patient was found to be ineligible at the timeof study entry because of previous taxane treatment. A second patient withdrew informed consent before the start of chemotherapy. Therefore, data for 48 patients were analyzed as a per-protocol population.
The characteristics of the patients at inclusion are summarized in Table 1. There were 36 men and 12 women, with a median age of 62 years, treated with docetaxel for prostate (52%), lung (21%), breast (19%), or other cancers (urinary bladder, head and neck, primary unknown for 8% of cases). The majority of patients (88%) had an ECOG PS of 0 or 1. Docetaxel was administered either as monotherapy (42%) or in combination therapy (58%) as a first-line treatment for 69% of patients. The other agents in combination were estramustine phosphate (56%), carboplatin (16%), cisplatin (12%), and others (erlotinib, trastuzumab, doxorubicin, and cyclophosphamide) in 16% of cases. The median number of cycles administered was 5 (range, 1–9 cycles) and the median cumulative dose was 720 mg (range, 150–1260 mg). There were 4 different dosages at Day 1 of the first cycle of docetaxel: 70 mg/m2, 75 mg/m2, 85 mg/m2, and 100 mg/m2; the percentage of corresponding patients were 38%, 29%, 6%, and 27%, respectively. Twelve of 48 patients (25%) experienced a docetaxel dose reduction, principally because of hematologic toxicity.
|Median (Range)
|No. of patients
|Age, y
|62 (36–80)
|ECOG performance status
|Type of tumor
|Lung (nonsmall cell)
|Docetaxel treatment
|Single agent
|Combination therapy
|No. of cycles
|5 (1–9)
|Cumulative dose, mg
|720 (150–1260)
|Docetaxel schedule, mg/m2
|Prior chemotherapy
The application of a FS significantly reduced the incidence of nail toxicity, with grade 1–2 toxicity occurring in none of the FS-protected feet compared with 21% in the unprotected feet (P = .002) (Table 2). Onycholysis occurred in only 2% of the control feet (Figures 2 and 3). Overall skin toxicity was registered in 2% of the FS-protected feet versus 6% of the unprotected feet. The difference was not statistically significant (P = .18) (Table 2). The time until nail toxicity occurrence for unprotected foot was significantly associated with the total number of cycles of docetaxel administered (HR of 0.36; 95% CI, 0.17–0.77; [P = .008]); a borderline correlation was found for ECOG PS (HR of 0.31; 95% CI, 0.09–1.10 [P = .07]). Patients with a poor ECOG PS presented with a short time interval until the occurrence of nail toxicity, with the risk found to be correlated with the cumulative number of cycles of chemotherapy. Age, previous chemotherapy, and the weight of the patients were not found to be associated with the risk of nail toxicity. The percentage of patients with no nail toxicity at 1 month, 2 months, and 3 months for the control foot were 98%, 81%, and 67%, respectively. No differences were observed in terms of time to the occurrence of nail and skin toxicity between protected and unprotected feet (105 days vs 87 and 101 days vs 101 days, respectively). An exploratory analysis performed on the data of patients treated with docetaxel in combination with different agents demonstrated no impact of the introduction of a second drug on the endpoint of study (nail toxicity).
|Grade of toxicity
|Nail toxicity after docetaxel treatment
|Control foot(n = 48)
|Protected foot(n = 48)
|Skin toxicity after docetaxel treatment
|Control foot (n = 8)
|Protected foot (n = 48)
|Toxicity grade
Assessment of patients' global comfort included factors such as sock contact, temperature tolerance, and immobilization constraints. Greater than half of the patients (58%) were satisfied and even very satisfied (19%) with the FS protection. Only 1 patient (2%) was dissatisfied because of FS-related cold intolerance (Table 3).
|Comfort assessment
|Global comfort(n = 48)
|Cold tolerance(n = 48)
|Very satisfied
Taxanes are important drugs in the treatment of breast, head and neck, lung, stomach, and prostate cancer. Although nail and skin toxicities are not life-threatening, clinicians should manage these particular side effects that could lead to an impairment of quality of life and early discontinuation of chemotherapy.14 Nail toxicity is now considered an important issue in taxane therapy. Even weekly schedules of docetaxel demonstrated a potential risk of nail toxicity, as demonstrated by a review performed in breast cancer patients.15 Not only taxanes are associated with important nail changes; antiangiogenic agents such as sunitinib and sorafenib were associated with distal subungual splinter hemorrhages in 30% and 60% of cases, respectively.16
Cold temperature had been found to decrease the toxicity (incidence and severity) of some cytotoxic agents as a direct consequence of the induced vasoconstriction, associated with a temporary decrease of blood flow. This approach was applied to prevent alopecia with the use of cold caps17, 18 and to prevent 5-fluorouracil-related mucositis using oral cryotherapy.19 The same concept was successfully tested for the prevention of nail and skin toxicities induced by docetaxel using an Elasto-Gel flexible frozen glove12 and therefore was extended in the current study to nail changes of the foot using a similar FS.
This matched, case-control, phase 2 study, performed in 45 patients with solid tumors who were treated with docetaxel-based regimens, demonstrated the feasibility and efficacy of cold therapy using the Elasto-Gel flexible FS to prevent docetaxel-induced nail toxicity of the foot. We believe the usefulness of cold therapy in preventing docetaxel-induced nail toxicity was confirmed and validated in the current study. The use of an FS reduced the incidence and intensity of nail toxicity associated with docetaxel, administered every 3 weeks, alone or in combination. No nail toxicity was observed in the FS-protected foot compared with an incidence of 21% in the control foot, including dischromia and onycholysis for 19% and 2% of cases, respectively. The incidence of skin toxicity was also reduced, but this finding was not statistically significant. Few patients presented grade 1 or 2 skin toxicity in the control group. In daily clinical practice, feet are less frequently affected than the hands by docetaxel-induced nail changes. This may be because of sock wear and light exposure prevention. In the previous study assessing frozen gloves, grade 1 and 2 nail toxicity occurred in 29% and 22% of the unprotected hand (compared with 19% and 2% in the unprotected foot of the current study), respectively. Grade 1 and 2 skin toxicity occurred in 44% and 9% of the control hand, compared with 4% and 2% in the control feet, respectively.12 The appearance of nail and/or skin toxicities of the foot was not significantly delayed by cold therapy, as had been observed using the frozen gloves. Overall, it appears that the FS was less effective, but the results are still statistically significant despite the small sample size for this cohort of patients.
The global comfort of patients as well as the cold tolerance assessed using a 4-point rating scale were excellent; only 1 patient was not satisfied with the FS, experiencing cold intolerance. These safety results appeared better than those obtained in the frozen gloves study, in which 14% of patients were dissatisfied, including 11% of those who withdrew from the study because of cold intolerance during glove contact.12 Therefore, the FS appears to be better tolerated than the gloves.
To our knowledge, the physiopathology of nail toxicity is actually unknown. Some studies have suggested that the antiangiogenic properties of taxanes may be involved,20, 21 whereas another study hints at the existence of a neurogenically mediated inflammatory process.22 De Giorgi et al.23 suggested that onycholysis might represent a side effect related to the vehicle cremophor for paclitaxel or Tween 80 for docetaxel, possibly through neurotoxic damage.
To our knowledge to date, no effective preventive measures are available to avoid taxane-induced nail changes. This technique, using Elasto-Gel frozen gloves and/or socks, is easy to apply and is well tolerated by the patients, with no major side effects reported. It may be recommended for routine use with taxane-based therapies and should be considered as a new valuable tool in supportive care. Because the FS did not affect skin toxicity, a modified version of the sock, covering only toes and nails, should be tested. The cold therapy must be tested with other cytotoxic agents known to be associated with important nail and skin toxicities such as liposomal doxorubicin. A similar study is ongoing in our center and the results will be presented in the near future.


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I live in the Wairarapa, New Zealand with my husband & 2x children. I have enjoyed helping people find lost & missing family members over the past few years. Feel free to leave me a message if you have extra information for someone.
I am trying to add all local entries, but I also enter the deaths from the local paper, so I can connect them with any family at these cemeteries. (I do not keep copies of the obituary). For those entries which I have just the year of death date I have estimated the persons birth date, if you know the correct DOB date let me know and I will insure the correct information is entered. I am not related to 99.9% of my entries.
Many people like being able to see family members headstones as they don't live near but others may not, If you want a family member removed feel free to let me know. I am happy to do this.
I don't need to be abused for this to happen.
If I have made an error I'm also happy to change this.
Cemeteries I have done and are complete are
Akura Urupa> Masterton
Ahipanepane Urupa> Te Ore Ore, Masterton
Hamuera Urupa> Gladstone
Oates Family Cemetery> Carterton
Te Uru o Tane Urupa (Blackbridge)> Greytown
Masterton War Memorial>
Mauriceville North, Wairarapa>
Mauriceville West, Wairarapa>
Waihenga Cemetery, South Wairarapa, Martinborough>
Taupo Old Maori Cemetery>
Some other Wairarapa Cemeteries are:
Ahi Tainga Urupa,> Bideford
Amahua Urupa,> Gladstone
Archer Street Cemetery> Masterton
Bideford Cemetery,> Bideford
Clareville Cemetery> Carterton
Greytown Cemetery>
Hurunui-o-rangi Urupa, Gladstone>
Kohunui Urupa,> Pirinoa
Martinborough Cemetery> Martinborough
Okautete Maori Cemetery> Homewood Riversdale
Pukio Cemetery> Kahutara, Featherston
Rangiurunga,> Greytown
Riverside Cemetery> Masterton
Tahoraiti Urupa >Dannevirke
Taupare Urupa >Homewood
Te Ahitainga Urupa> Masterton
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Contributions to
Find A Grave
10,033 Memorials Added
10,033 Memorials Managed
40 Memorials/Week
13,913 Photos
9 Photo Requests
45 Volunteer Photos Taken
5 Virtual Flowers
1 Virtual Cemetery
3 Fame Ratings
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S. Melton
Messages left for Jo Jo (103)
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Memorial# 155297185 Clark
Memorial# 152107493 Milne
The memorials above have been placed in the Waihenga Cemetery, Dublin Street, Martinborough. I believe they should be located in the Martinborough Cemetery, Huangarua/Puruatanga Road.
The naming and addresses given for the two cemeteries in Martinborough appear to have have caused some confusion as there are around 14 memorials incorrectly placed by various members at Waihenga. I will ask Find A Grave to amend the cemetery details to get better clarity.
Rgds - Jonty
Added by
on Sep 24, 2016 5:21 PM
S. Melton
RE: Eloise Cassidy
Thanks, I deleted it.
Added by
S. Melton
on Aug 30, 2016 7:44 PM
Ms. Clyde
RE: Eloise Cassidy
Sorry, I didn't mean to notify you. I always try and notify the duplicate NOT the original. I'll track and notify Find A Grave to combine if needed.
Added by
Ms. Clyde
on Aug 30, 2016 7:51 AM
Ms. Clyde
Eloise Cassidy
Your memorial for Eloise is 145340471 (Burial unknown)
There is another memorial for her in a cemetery, with plot info; see 156815231
If there is a 'burial unknown', then followed by a memorial for the same person in a cemetery, then even though the latter was entered after the original, it takes precedence. Find A Grave Help Page reads �In regard to duplicates, a memorial with a correct known burial location will always be preferred over an unknown burial location.
Please check on this.
Added by
Ms. Clyde
on Aug 24, 2016 8:54 AM
David Grimshaw
Edwin Ticehurst
Hi Jo,
Did you know that Edwin Ticehurst had a grandson of the same name?
Added by
David Grimshaw
on Jul 19, 2016 11:12 AM
Christine M Clayton
Robert STURM
Hi Jo, Wairoa Cemetery Database has a nice headstone photo of Jeannie and Rudolph STURM that you have asked a photo request for :-)
Added by
Christine M Clayton
on Jul 15, 2016 1:17 AM
Daniel Peck
Hi there i was just randomly typing in some names of people that my parents knew back in the day, and one of which was a lady named Jimmy Tarrant. She used to live down cornwall place, masterton. She had a Jack potangaroa living with her back then. Such nice people thinking back on it. was wandering if you knew jimmy at all?
Kind Regards,
Daniel Peck
Added by
Daniel Peck
on Jun 26, 2016 12:56 AM
Flutey Muddle
Thank you for taking the time to check on things re William Oxley Flutey and get it all sorted out. Much appreciated.
Added by
on Jun 22, 2016 8:53 PM
Duplicate memorials
You appear to have established the following duplicate memorials. The originals were established by 'pkg' (#46968786) back in 2010.
RSA Woodville/Woodville Services Lawn cemetery.
Rgds Jonty
Added by
on Jun 20, 2016 6:19 PM
Re previous message
Since posting that message I have investigated the burial records for Masterton and found that William Oxley Flutey is NOT in the Archer street Cemetery but in the Riverside Cemetery -
Burial Record
Record Detail
Item Value
Record Number: 013238
Surname: FLUTEY
First Names: WILLIAM OXLEY
Age: 75
Date of Death: 22/07/1989
Date of Burial: 25/07/1989
Cemetery: Riverside
Area: Lawn A
Row: D
Plot: 17
Can you please look into this matter.
Added by
on Jun 16, 2016 3:52 PM
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Neurologic disorders of gait
DOI: 10.1007/s11910-001-0089-4
- Cite this article as:
- Sudarsky, L. Curr Neurol Neurosci Rep (2001) 1: 350. doi:10.1007/s11910-001-0089-4
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Gait disorders are important because of their prevalence, particularly among the elderly, and the associated risk of falls and injury. Neural networks that organize locomotion and maintain balance are briefly reviewed. Gait disorders can be classified based on observational features or by etiology. Several common disorders are discussed in more detail. Recent progress includes use of botulinum toxin for spastic gait in cerebral palsy, neurosurgical treatment of Parkinson's disease, and newer rehabilitation approaches to gait and balance training.


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WordPress medical style website with customer 5 star rating and review systems
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- Steam crashes when loading certain fonts have been fixed
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It's been a long time since I last made something gluten free, no that's not true because I often make gluten free food but its almost always food that is naturally GF . So let's put it this way, I haven't done any GF baking for a long time but today I have recipe for Gluten free polenta and rice cookies that have a wonderful intense lime flavour. I find it quite hard to make cookies with a really zesty lemon or lime taste but this time I was successful and I'm eating these cookies non stop right now. I will regret that soon. They are very tender and the only negative aspect I can find is that they are a bit crumbly the first hours.
135 g/4 3/4 oz butter
150 g/5 1/4 oz sugar
1 egg yolk
200 g/ 6 oz corn starch
100 g/ 3 oz rice flour
80 g/ 2 3/4 oz polenta flour
2 limes, juice and grated zest
– Stir butter and sugar smooth and incorporate the egg yolk.
– Add the lime juice and the grated zest and stir well.
– Sift corn starch and rice flour into the mixture and then add the polenta flour. Now, if you don't like the crunch that polenta flour gives the cookie, I suggest you to let soak a bit in a little, very little, water before adding it in order to make it softer.
– Mix the dough well and then make small balls that you flatten out with a for on a baking sheet.
– Bake in a pre-heated oven (175°C/347°F) for about 10-15 minutes, check them often.
– Let them get cold before you move them.