text: Ezcorp Company Profile (NASDAQ:EZPW) Analyst Ratings Earnings Estimates Dividends Insider Trades Headlines Social Company Profile Chart About Ezcorp EZCORP, Inc. provides pawn loans in the United States and Mexico, and consumer loans in Mexico. The Company operates through four segments: U.S. Pawn, which includes its EZPAWN, value pawn and jewelry, and other branded pawn operations in the United States; Mexico Pawn, which includes its Empeno Facil pawn operations and cash converters buy/sell store operations in Mexico; Grupo Finmart, which includes its Crediamigo and Adex payroll withholding loan operations in Mexico, and Other International, which includes its CASHMAX financial services operations in Canada and its equity interest in Cash Converters International. It offers pawn loans, which are non-recourse loans, collateralized by tangible property, and it sells merchandise, primarily collateral forfeited from pawn lending operations and used merchandise purchased from customers at its pawn stores. Through its subsidiary, Prestaciones Finmart, S.A.P.I. de C.V., SOFOM, E.N.R., it offers unsecured installment loans to employees. Industry, Sector and Symbol: Sector: Finance Industry: Credit Services Sub-Industry: Consumer Finance Exchange: NASDAQ Symbol: EZPW CUSIP: 30230110 Key Metrics: Previous Close: $9.9450 Day Moving Average: $9.95200 Day Moving Average: $6.9752-Week Range: $2.44 - $10.62Trailing P/E Ratio: N/AForeward P/E Ratio: 18.07P/E Growth: -1.26Market Cap: $536.57MOutstanding Shares: 53,981,000Beta: 1.66Profitability:Net Margins: -23.29%Return on Equity: -3.34%Return on Assets: -1.93%Debt:Debt-to-Equity Ratio: 0.37%Current Ratio: 2.58%Quick Ratio: 1.95% Additional Links: Visit Ezcorp's Official WebsiteView EZPW on Google FinanceView EZPW on Yahoo FinanceView EZPW's Company Profile on ReutersSearch for Ezcorp Inc. on Google Companies Related to Ezcorp:First Merchants Corp. (NASDAQ:FRME)United Fire Group (NASDAQ:UFCS)Fortress Investment Group LLC (NYSE:FIG)HFF (NYSE:HF)WSFS Financial Corp. (NASDAQ:WSFS)Stewart Information Services Corp. (NYSE:STC)Beneficial Mutual Bancorp (NASDAQ:BNCL)Boston Private Financial Holdings (NASDAQ:BPFH)First Bancorp (NYSE:FBP)James River Group Holdings (NASDAQ:JRVR) Analyst Ratings Consensus Ratings for Ezcorp (NASDAQ:EZPW) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: 1 Hold Rating, 2 Buy RatingsConsensus Rating:Buy (Score: 2.67)Consensus Price Target: $10.13 (1.86% upside) Analysts' Ratings History for Ezcorp (NASDAQ:EZPW) Show: All Ratings For This Stock Only the Most Recent Rating From Each Brokerage DateFirmActionRatingPrice TargetDetails8/17/2016CL KingUpgradeNeutral -> Buy$11.258/4/2016Jefferies GroupReiterated RatingHold$9.007/7/2016Wells Fargo & Co.UpgradeMarket Perform -> Outperform(Data available from 9/27/2014 forward) Earnings Earnings History for Ezcorp (NASDAQ:EZPW)DateQuarterConsensus EstimateActual EPSRevenue EstimateActual RevenueRelease LinkConference CallDetails12/22/2016 8/9/2016Q3($0.01)$0.05ViewN/A5/9/2016Q2($0.07)($0.07)ViewN/A2/9/2016Q1($0.06)($0.13)$219.00 million$198.50 millionViewListen1/27/2015Q115$0.36$0.26$244.20 million$252.60 millionViewN/A11/6/2014Q414$0.33$0.27$252.70 million$143.92 millionViewN/A7/29/2014Q314$0.25$0.21$245.60 million$241.00 millionViewN/A4/29/2014Q214$0.35$0.36$264.44 million$260.00 millionViewN/A1/27/2014Q114$0.39$0.49$255.28 million$269.00 millionViewN/A11/7/2013Q313$0.46($0.48)$248.73 million$234.37 millionViewN/A7/30/2013Q3 2013$0.42$0.29$240.27 million$235.20 millionViewN/A4/30/2013Q2 2013$0.62$0.63$275.33 million$272.07 millionViewN/A1/22/2013Q1 2013$0.58$0.59$268.92 million$277.10 millionViewN/A11/6/2012Q412$0.75$0.75$260.75 million$258.40 millionViewN/A7/24/2012$0.61$0.56ViewN/A4/19/2012$0.76$0.73ViewN/A1/19/2012$0.81$0.78ViewN/A11/8/2011$0.70$0.72ViewN/A7/21/2011$0.54$0.53ViewN/A1/20/2011$0.62$0.69ViewN/A(Data available from 1/1/2011 forward) Estimates Earnings Estimates for Ezcorp (NASDAQ:EZPW)Current Year EPS Consensus Estimate: $-1.57 EPSNext Year EPS Consensus Estimate: $0.55 EPSQuarterNumber of EstimatesLow EstimateHigh EstimateAverage EstimateQ3 20161($0.12)($0.12)($0.12)Q4 20161$0.05$0.05$0.05Q1 20171$0.17$0.17$0.17Q2 20171$0.17$0.17$0.17Q3 20171$0.13$0.13$0.13Q4 20171$0.15$0.15$0.15(Data provided by Zacks Investment Research) Dividends Dividend History for Ezcorp (NASDAQ:EZPW)No dividend announcements for this company have been tracked by MarketBeat.com Insider Trades Insider Trading History for Ezcorp (NASDAQ:EZPW)Insider Ownership Percentage: 2.13%Institutional Ownership Percentage: 79.56%Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionDetails2/6/2014Barry William GuestInsiderSell2,500$11.32$28,300.00 1/31/2014Mark Edward KuchenritherCFOBuy1,000$11.18$11,180.00 1/31/2014Paul RothamelCEOBuy13,250$11.15$147,737.50 11/12/2013James William WhatleyInsiderSell5,739$11.85$68,007.15 7/22/2013Sterling B BrinkleyChairmanSell9,833$18.60$182,893.80 6/21/2013Sterling B BrinkleyChairmanSell16,250$18.18$295,425.00 5/22/2013Sterling B BrinkleyChairmanSell16,250$18.96$308,100.00 (Data available from 1/1/2013 forward) Headlines Latest Headlines for Ezcorp (NASDAQ:EZPW)DateHeadlineEZCORP, Inc. (NASDAQ:EZPW)'s Expectation Of $733.69 In Sales - Investor Newswire (NASDAQ:EZPW)www.investornewswire.com - September 20 at 8:48 AMEZCORP : Reschedules Its Third Quarter Fiscal 2016 Earnings Release (NASDAQ:EZPW)www.4-traders.com - September 17 at 9:39 AMEZCORP INC Files SEC form 8-K, Entry into a Material Definitive Agreement (NASDAQ:EZPW)biz.yahoo.com - September 16 at 4:51 PMStock Update on Earnings & Estimates for EZCORP, Inc. (NASDAQ:EZPW) - Frisco Fastball (NASDAQ:EZPW)friscofastball.com - September 16 at 8:41 AMSell-side is Weighing in on EZCORP, Inc. (NASDAQ:EZPW) Earnings - Frisco Fastball (NASDAQ:EZPW)friscofastball.com - September 14 at 10:07 PMAnalysts Take the Wheel on EZCORP, Inc. (NASDAQ:EZPW) Shares and Where They Might Be Headed - Frisco Fastball (NASDAQ:EZPW)friscofastball.com - September 14 at 9:07 AMResearch Analysts Set EZCORP, Inc. (NASDAQ:EZPW)'s Price Target At $10.125 - RealistInvestor.com (NASDAQ:EZPW)www.realistinvestor.com - September 14 at 9:07 AMEZCORP INC : Regulation FD Disclosure (form 8-K) (NASDAQ:EZPW)www.4-traders.com - September 13 at 9:48 AMEZCORP INC Files SEC form 8-K, Regulation FD Disclosure (NASDAQ:EZPW)biz.yahoo.com - September 13 at 9:48 AMEZCORP, Inc. (NASDAQ:EZPW) Mean Price Target At $10.125 - Investor Newswire (NASDAQ:EZPW)www.investornewswire.com - September 12 at 4:47 PMShares Spotted Rising Up to a Recent High: EZCORP, Inc. (NASDAQ:EZPW) - Post News (NASDAQ:EZPW)www.kentuckypostnews.com - September 7 at 8:16 AMEZCORP, Inc. (NASDAQ:EZPW) Expects Sales Of $733.69 - Investor Newswire (NASDAQ:EZPW)www.investornewswire.com - September 5 at 4:37 PMEZCORP, Inc. (NASDAQ:EZPW) Is Expected To Post EPS Of $0.13 - RealistInvestor.com (NASDAQ:EZPW)www.realistinvestor.com - September 5 at 4:37 PMPrice Target For EZCORP, Inc. (NASDAQ:EZPW) Set At $10.125 By Research Analysts - RealistInvestor.com (NASDAQ:EZPW)www.realistinvestor.com - September 1 at 6:25 AMStock in Review: Taking a Closer Look at EZCORP, Inc. (NASDAQ:EZPW) Shares - Post News (NASDAQ:EZPW)www.kentuckypostnews.com - September 1 at 6:25 AMCash Converters International Ltd Reports Higher Full Year 2016 Underlying Profit (NASDAQ:EZPW)www.4-traders.com - August 30 at 8:00 AMEZCORP, Inc. (NASDAQ:EZPW) Expects To Hit Sales Of $733.69 - Investor Newswire (NASDAQ:EZPW)www.investornewswire.com - August 29 at 4:51 PMEZCORP, Inc. (NASDAQ:EZPW) Stock Rating Update - Investor Newswire (NASDAQ:EZPW)www.investornewswire.com - August 29 at 9:36 AMSurging Earnings Estimates Signal Good News for EZCORP (EZPW) - Nasdaq (NASDAQ:EZPW)www.nasdaq.com - August 27 at 9:34 AMSurging Earnings Estimates Signal Good News for EZCORP (EZPW) (NASDAQ:EZPW)finance.yahoo.com - August 26 at 4:50 PMEZCORP Chief Executive Officer, Stuart Grimshaw, to Speak at CL King 14th Annual Best Ideas Conference in New York City on September 13, 2016 (NASDAQ:EZPW)finance.yahoo.com - August 25 at 10:11 PMSpecialty Retailers Defying Sector Gravity (ROST, DKS) (NASDAQ:EZPW)www.investopedia.com - August 25 at 4:58 PMETF's with exposure to EZCORP, Inc. : August 22, 2016 (NASDAQ:EZPW)www.capitalcube.com - August 22 at 4:59 PMWhy EZCORP (EZPW) Could Be a Potential Winner (NASDAQ:EZPW)finance.yahoo.com - August 16 at 5:03 PMEdited Transcript of EZPW earnings conference call or presentation 10-Aug-16 12:30pm GMT (NASDAQ:EZPW)finance.yahoo.com - August 10 at 11:06 PMEzcorp reports 3Q loss (NASDAQ:EZPW)sg.finance.yahoo.com - August 10 at 12:19 PMEZCORP Announces Third Quarter Fiscal 2016 Results (NASDAQ:EZPW)www.publicnow.com - August 10 at 12:19 PMEZCORP, Inc. to Release Third Quarter FY2016 Results After Market Close on Tuesday, August 9, 2016 (NASDAQ:EZPW)www.publicnow.com - August 9 at 3:39 PMEZCORP (EZPW) to Delay Q3 Release; Needs More Time to Reconcile Balance Sheet Tax Accounts (NASDAQ:EZPW)www.streetinsider.com - August 4 at 10:42 PMEZCORP Inc.: EZCORP, Inc. Reschedules Its Third Quarter Fiscal 2016 Earnings Release (NASDAQ:EZPW)www.twst.com - August 4 at 10:42 PMEZCORP, Inc. Reschedules Its Third Quarter Fiscal 2016 Earnings Release (NASDAQ:EZPW)www.publicnow.com - August 3 at 5:11 PMEZCORP, Inc. to Release Third Quarter FY2016 Results After Market Close on Wednesday, August 3, 201 (NASDAQ:EZPW)www.nasdaq.com - July 29 at 10:19 PMEZCORP, Inc. to Release Third Quarter FY2016 Results After Market Close on Wednesday, August 3, 2016 (NASDAQ:EZPW)finance.yahoo.com - July 29 at 2:08 PMMexico's AlphaCredit buys 95 percent of Finmart from EZCORP (NASDAQ:EZPW)feeds.reuters.com - July 12 at 1:55 PMNew 52 Wk Peaks – TWER, LEDS EZPW, PXG, EVOK, SODA, VEEV (NASDAQ:EZPW)www.fxpips.com - July 9 at 8:26 AMEZCORP Inc. (EZPW) Climbed To A New High Following Upgrade (NASDAQ:EZPW)www.rttnews.com - July 8 at 4:57 PMPawn Shop Operator EZCORP (EZPW) Sells Consumer Loans Business (NASDAQ:EZPW)www.economiccalendar.com - July 8 at 4:57 PMEZCorp to sell Mexican payday loans business (NASDAQ:EZPW)www.bizjournals.com - July 7 at 10:07 PMEZCORP Shares Spike Up On Announcement Of Dividend Of $1.50 Per Share (NASDAQ:EZPW)www.investing.com - July 7 at 10:07 PMEZCORP upgraded by Wells Fargo (NASDAQ:EZPW)finance.yahoo.com - July 7 at 7:02 AMEZCORP INC Files SEC form 8-K, Entry into a Material Definitive Agreement, Regulation FD Disclosure (NASDAQ:EZPW)biz.yahoo.com - July 6 at 5:26 PMEZCORP (EZPW) to Sell Grupo Finmart in $50M Deal (NASDAQ:EZPW)www.streetinsider.com - July 6 at 5:03 PMEZCORP ENTERS INTO AGREEMENT TO SELL GRUPO FINMART (NASDAQ:EZPW)www.publicnow.com - July 6 at 4:41 PMETF's with exposure to EZCORP, Inc. : June 21, 2016 (NASDAQ:EZPW)www.capitalcube.com - June 21 at 12:58 PMRetail Trade Sector's Winners and Losers, June 21 (NASDAQ:EZPW)www.fxpips.com - June 21 at 9:35 AMETF's with exposure to EZCORP, Inc. : June 8, 2016 (NASDAQ:EZPW)www.capitalcube.com - June 8 at 2:19 PMRetail Trade Stocks Losers, Gainers, June 6 (NASDAQ:EZPW)www.fxpips.com - June 7 at 8:50 AMEZCORP (EZPW) Looks Good: Stock Jumps 5.3% in Session (NASDAQ:EZPW)www.zacks.com - June 7 at 8:50 AMFitch Downgrades Finmart to 'B-'; Rating Watch Evolving (NASDAQ:EZPW)www.reuters.com - June 2 at 11:03 PMStock Rating Review for EZCORP, Inc. (NASDAQ:EZPW) - Wall Street Hints and News (NASDAQ:EZPW)hintsnewsnetwork.com - May 25 at 2:18 PM Social Ezcorp (NASDAQ:EZPW) Chart for Tuesday, September, 27, 2016 Last Updated on 9/27/2016 by MarketBeat.com Staff


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Andrej Brummer, is a biologist who studied marine biology and ecology extensively at university, hates the over complication of scientific topics and grew up at the beach in New Zealand. He has worked as a cancer research scientist for 9 years but was always way more fascinated with marine organisms than human cells…
His love affair with the denizens of the ocean began at an early age, where he and his sisters would spend hours exploring rock pools. When Andrej was 6 his father moved to Thailand, so every trip to visit him involved snorkeling and examining the weird and wonderful creatures that live in tropical reef environments.
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This led to a quick realisation that a saltwater aquarium really is a science which in turn led to a keen interest in biology and a lot of marine life based research for Andrej.
Jump forward 10 years and Andrej has spent a lot of time in the lab learning about creating optimum marine environments and the ins and outs of maintaining super-healthy eco-systems.
Quickly Andrej realised for quite a complicated hobby, there is very little quality information around and often what information you do find is contradicted by another website, book or self-proclaimed "expert" online.
The bottom line is a saltwater aquarium has very little room for error, so you need to get it right!
Andrej decided to combine his scientific training and keen passion for marine life to use in creating and maintaining thriving saltwater aquariums. So after being asked countless questions by other marine aquarists (some of them were even biochemists!), Andrej decided to write his "Ultimate Secrets To Saltwater Aquarium Fish and Invertebrates" to set the story straight. But also to translate all the technical information into an easy to understand format.
Andrej: "My goal for my book , Facebook page, VIP club and my blog is to help people avoid all the common mistakes that end up with 80% of saltwater aquarium owners leaving the hobby after 2 years, usually down a few thousand dollars."
"I really want to provide the best information anywhere and help saltwater aquarium owners around the world enjoy the thrill of their own thriving marine aquarium."
Andrej really believes the saltwater aquarium hobby is really important to the future of the planets marine species because it is a way of repopulating the oceans wild stocks of endangered corals, marine fish and invertebrates…by learning how to get these animals to reproduce in captive systems. Having a thriving saltwater aquarium and being part of this should be something that anybody can learn how to do without making crucial mistakes.
Andrej has so far sold over 3000 copies of his book and has thousands of followers on his blog and Facebook page.
If he could he would spend the rest of his life underwater discovering new species and learning how to save the coral reefs of the world…[/vc_column_text]

subset: commoncrawl


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How your brain handles fear
Fear is the brain's hard-wired survival mechanism. There are three key players in this system:
• The thalamus is your brain's window to the world. It receives and processes at a low level sensory input and sends messages to:
• The amygdala, which scans the information for threats and musters a full body response if danger is detected, and
• The prefrontal cortex. This higher level brain area integrates the sources of information and analyzes them in light of past experiences. It can keep the fear response from spiraling out of control by inhibiting the amygdala.
Click here to view these players in a rotating 3-D brain model.
The amygdala gets sensory messages from the thalamus first because it is connected along a shorter, narrower pathway than the prefrontal cortex. Plus, it receives only about five percent of the sensory input. This is a good thing. Otherwise you'd likely be overwhelmed with panic because the amygdala can unleash a powerful reaction. It prepares you to flee, fight or freeze.
• Your heart starts beating rapidly
• You start taking quick, shallow breaths and sweating
• Your hearing and vision narrow down to pinpoint focus on the perceived threat
The prefrontal cortex receives the other 95 percent of the sensory input from the thalamus about a quarter of a second later. This brief lag with its higher functioning allows reason and experience to take hold, to expand your realm of explanations, change your perception and transform fear into something more logical. For example, realizing the banging of your front door at night is caused by the wind, not a burglar, and so you latch it tight rather than empty a shotgun round into it.
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The National Archives released about 1,000 pages of documents Friday. About 20,000 pages of Clinton records have been released since February.
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Esophageal adenocarcinoma is preceded by the development of reflux-related intestinal metaplasia or Barrett's esophagus which is a response to inflammation of the esophageal squamous mucosa, reflux esophagitis. Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the squamous epithelium to the diverse microbial ecosystem or microbiome, and inducing chronic inflammation. The esophageal microbiome is altered in both esophagitis and Barrett's esophagus, characterized by a significant decrease in Gram-positive bacteria and an increase in Gram-negative bacteria in esophagitis and Barrett's esophagus. Lipopolysaccharides (LPS), a major structure of the outer membrane in Gram-negative bacteria, can up-regulate gene expression of proinflammatory cytokines via activation of the TLR4 and NF-kB pathway. The potential impact of LPS on reflux esophagitis may be through relaxation of the lower esophageal sphincter via iNOS and by delaying gastric emptying via COX-2. Chronic inflammation may be play a critical role in the progression from benign to malignant esophageal disease. Therefore analysis of the pathways leading to chronic inflammation in the esophagus may help to identify biomarkers in Barrett's esophagus patients for neoplastic progression and provide insight into molecular events suitable for therapeutic intervention in prevention of esophageal adenocarcinoma development in patients with reflux esophagitis and Barrett's esophagus.
Esophageal adenocarcinoma, the malignant transformation at the end of a spectrum of diseases related to gastroesophageal reflux, is now the most rapidly increasing cancer in the Western world. Barrett's esophagus is defined as the metaplastic columnar epithelium that replaces squamous mucosa and predisposes to cancer development (1). The rate of progression from Barrett's esophagus to esophageal adenocarcinoma is approximately 0.12–0.4% per patient-year (2–4). For unclear reasons the incidence of esophageal adenocarcinoma in the US has risen approximately 600% since the 1970s (5–7), and since its development is not universal among patients with Barrett's esophagus, it is important to understand and to gauge the factors that influence risk of progression to dysplasia and cancer. The current review aims to highlight the new insights into mechanisms underlying host-bacterium interaction in the context of reflux-induced inflammation and esophageal carcinogenesis. In particular the influence of microbial lipopolysaccharides (LPS) on the molecular pathways involved in inflammation-associated esophageal tumorigenesis will be examined.
The term "microbiome", coined by Joshua Lederberg, refers to the collection of all members in a complex microbial community (8). The host relationship with the microbiome can be commensal, symbiotic, or pathogenic. Bacterial mutualists within the gastrointestinal tract aid digestion benefit from the host as they assist in the synthesis of vitamins, promote development of the gut immune system, and provide competitive barriers to pathogen invasion. This complex microbial population influences an estimated 10% of all metabolites in our body (9). In return the host provides bacteria with safe housing and food during lean times. In order for this symbiotic relationship to be sustained, the immune system has to balance permissive, tolerogenic responses to food antigens and commensal microbes with potentially damaging, inflammatory responses to ward off pathogens. This delicate balance is maintained by the constant interplay among the microbiome, the gastrointestinal barrier, and the mucosal immune system, which is a prerequisite for normal gut homeostasis. Imbalance of this system may lead to innate immune (inflammation) and adaptive immune (infectious pathology) responses.
Reflux esophagitis and Barrett's esophagus represent phenotypes of inflammation of the esophageal mucosa induced by long-term gastric acid and bile reflux into the esophagus. The gastroesophageal reflux impairs the mucosal barrier and exposes the squamous epithelium and lamina propria to 1) the microbes swallowed from the oral cavity, colonized in the esophagus, and regurgitated from the stomach, 2) acidic gastric contents, and 3) bile from the duodenum.
A recent study of human distal esophageal microbiome linked inflammation and Barrett's esophagus to the change in the microbiome. The study used 16S rRNA gene survey to characterize the bacterial communities in biopsy samples taken from the distal esophagus (10). With an unsupervised approach, samples of the microbiome form two distinct clusters or two microbiome types, type I and II, based on combined genetic distance among samples. Although neither of the two types of clusters correlated exclusively with esophageal phenotypes, the type I microbiome is more closely associated with normal esophagus (11/12, 91.7%), whereas the type II microbiome is mainly associated with abnormal esophagus (13/22, 59.1%) (p=0.0173 among group comparison), including both esophagitis (7/12, 58.3%, odds radio=15.4) and Barrett's esophagus (6/10, 60.0%, odds radio=16.5). Thus alteration of the microbiome from type I to type II in the distal esophagitis is associated with host phenotypes and its disease progression. The type I microbiome is dominated by Gram-positive bacteria representing the Firmicutes phylum. In contrast the type II microbiomes composed of larger numbers of Gram-negative bacteria in phyla Bacteroidetes, Proteobacteria, Fusobacteria, and Spirochaetes. Streptococcus is the most dominant genus in the esophageal microbiome and its relative abundance is significantly higher in the type I microbiome (78.8%) than in the type II microbiome (30%). In the type II microbiome the decrease in the relative abundance of Streptococcus is compensated by an increase in the relative abundance of 24 other genera. Specifically, the most prominent increase involves Veillonella, Prevotella, Haemophilus, Neisseria, Rothia, Granulicatella, Campylobacter, Porphyromonas, Fusobacterium, and Actinomyces, many of which are Gram-negative anaerobes or microaerophiles and are putative pathogens for periodontal disease. Overall, Gram-negative bacteria comprise 53.4% of type II microbiome but only 14.9% of type I microbiome.
The type II microbiome with its larger content of Gram-negative bacteria might engage innate immune functions of the epithelial cells in a different way than the type I microbiome, owing to their production of a larger amounts of Gram-negative microbial components, for instance LPS. The bacterial products may directly or indirectly stimulate pattern receptors (i.e., Toll-like receptors) in the epithelial or inflammatory cells to promote expression of proinflammatory cytokines and persistent innate immune responses in the esophagus. Since many of the periodontal pathogens in the type II microbiome are known to cause inflammation in the mouth, it is plausible that they may similarly contribute to the development and maintenance of chronic inflammation in the esophagus. The change from microbiome type I to type II might thus prove to be an important step in the pathogenesis of esophageal tumorigenesis in progression of reflux esophagitis and Barrett's esophagus and development of esophageal adenocarcinoma.
The current strategy for Barrett's esophagus screening and surveillance may not be cost-effective and has not been shown to reduce esophageal adenocarcinoma incidence or mortality (4, 11). Indeed, data regarding risk factors for Barrett's esophagus have not been systematically applied to screening guidelines, and the current state of the art for screening focuses primarily on endoscopic evaluation of individuals with chronic reflux symptoms. A surveillance interval of 3–5 years has been suggested for individuals without dysplasia, 6–12 months for low grade dysplasia, and every 3 months for high grade dysplasia (1). Much investigation is currently underway to identify prognostic biomarkers that may determine the best diagnostic and therapeutic course in esophageal adenocarcinoma.
LPS, the major outer membrane component present in Gram-negative bacteria, consists of a lipid core and polysaccharide side chain joined by a covalent bond. LPS acts as the prototypical endotoxin to promote the secretion of pro-inflammatory cytokines in many cell types. Host responses to Gram-negative LPS are mediated mainly through activation of toll-like receptor 4 (TLR4) (Figure 1). LPS molecules first bind plasma derived LPS-binding protein and then interact with cluster of differentiation 14 (CD14) expressed mainly by macrophages, neutrophil granulocytes, dendritic cells, and local gastrointestinal epithelial cells to form a ternary complex, LPS: LPS-binding protein:CD14, which further transfers LPS to TLR4 accessory protein MD2 complex (12). This leads to the activation of TLR4 and the downstream nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to evoke an inflammatory response. LPS might indirectly activate the NF-κB pathway of the epithelial cells by inducing inflammatory cells to produce interleukin-1 beta (IL-1β), or tumor necrosis factors-alpha (TNF-α) that may then engage cytokine receptor(s) through alternative pathway (non-canonical)(13–14)(Figure 1).
NF-κB activation is important in the initial cellular response to chemical, bacterial, or viral stimuli. It is a major transcription factor that regulates genes responsible for both the innate and adaptive immune response. It is normally predominantly located in the cytoplasm, but translocates to the nucleus upon activation. While the normal esophagus has no detectable active NF-κB, high levels of active NF-κB are found in esophageal adenocarcinoma in the setting of reduced levels of IκB-α (a known inhibitor of NF-kB) (15). There is a stepwise increase in the activation of NF-κB pathway along the spectrum of reflux esophagitis (16–17), Barrett's epithelium (18–19), and adenocarcinoma (16, 19–20), parallel to an increase in IL-1β, IL-6, IL-8, and TNF-α.
The NF-κB pathway can be triggered by exposingcells to LPS from Gram-negative bacteria, Peptidoglycan from Gram-positive bacteria, inflammatory cytokines (such as TNF-α or IL-1β), or by other physiological and non physiological stimuli (Figure 1).Microbial components activate the NF-κB pathway via Toll-like receptors (TLRs) signaling through the classical pathway (canonical), while cytokines via cytokine receptors (such as IL-1Rs, TNFRs, and other TNFR-like receptors) through the alternative pathway (non-canonical)(21). Peptidoglycan can also activate the NF-κB pathway by stimulating the Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) 1 (22–23) and 2 (24–26). Moreover, the observations of NF-κB activation in responses to inflammatory signaling through mutated NOD2 gene in Crohn's disease (24–25) and through NOD1 in infection with Helicobacter pylori (23) and Chlamydophila pneumoniae (22) raise some interesting possibilities in relation to human cancers developed in these inflammatory diseases. Despite evidence of TLRs 1, 2, 3, 4, 5, 7, 9 expression in human esophageal epithelial cells (27–28), their degree of expression varies among individuals and their roles in NF-kB activation in reflux disorders remain poorly defined.
NF-κB is important in reflux disorders because of its broad role in up-regulating its downstream target gene expressions involved in inflammation, innate immune responses, adaptive immune responses, apoptosis blocking, cell proliferation, and cell differentiation. It directly contributes to innate immune responses in reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma, and may ultimately determine the rate of progression to esophageal adenocarcinoma. NF-κB-regulated pro-inflammatory cytokines, IL-1β, IL-8 are stepwise increased in reflux esophagitis, Barrett's esophagus towards esophageal adenocarcinoma (14, 18, 24), and IL-4, IL-6 are also increased in reflux esophagitis and Barrett's esophagus (14, 19). It is notable that Fitzgerald et al. found no difference in the levels of IL-1β and IL-8 between non-inflamed squamous mucosa and Barrett's esophagus in the same patient (29). The secreted cytokines, including TNF and IL-1β, may also start a feedback loop for a second phase of NF-κB activation that continues the induction of robust innate immune responses. The cellular pattern recognition receptors (PRRs) such as TLRs, retinoic acid-inducible gene Ilike receptors (RLRs) and NOD-like receptors, which all sense microbial opportunistic pathogens or pathogens, and Pathogen-associated molecular patterns, use distinct signaling pathways that eventually converge to activate NF-κB, leading to the production of inflammatory mediators(21) (Figure 1).
NF-κB activation also up-regulates the expression of genes encoding proinflammatory enzymes, such as Cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) (Figure 1). COX-2 protein expresses in the epithelial cells in Barrett's metaplasia and its level of expression is elevated in esophageal adenocarcinoma (30–33). The elevation in expression occurs along the progression from low-grade dysplasia to high-grade dysplasia in Barrett's esophagus and esophageal adenocarcinoma (31). iNOS expression is also increased in esophageal adenocarcinoma (32) and in the lower esophageal sphincter in mouse model (34). Increased expressions of both iNOS and COX-2 have been demonstrated in inflammatory bowel disease, such as ulcerative colitis (35), and Crohn's disease (24–26).
Two major opposing factors stand out among the mechanisms that determine the development of pathological reflux. One is the lower esophageal sphincter which serves as a gatekeeper against reflux and the other is increased intragastric pressure which promotes reflux. Studies in a mouse model for sepsis illustrates that in normal mice, the lower esophageal sphincter maintains a basal tone, but LPS causes a dose-dependent fall in the basal tone, and the LPS's effect can be blocked by L-canavanine which is a selective iNOS inhibitor (34). In this rodent model, LPS caused a selective increase in iNOS protein and mRNA in both the lower esophageal sphincter and internal anal sphincter without significant changes in the expression of other NOS isozymes. In LPS-treated mice, the increased iNOS activates mitogen-activated protein kinase signaling pathway by phosphorylation of mitogen-activated protein kinases (36). Mitogen-activated protein kinases, including a family of serine and threonine kinases of ERK, JNK, and p38, convert external stimuli into a wide range of cellular responses, such as proliferation, survival, differentiation and migration. Because of these critical functions, deregulated mitogen-activated protein kinases are often found to contribute to the development of many cancers (37). The increased Gram-negative bacteria in the type II microbiome in reflux esophagitis and Barrett's esophagus could serve as the trigger of the NF-kb pathway and be responsible for the up-regulation of the iNOS gene. Thus, the type II microbiome might cause abnormal relaxation of the lower esophageal sphincter and contribute to the etiology of gastroesophageal reflux and carcinogenesis of esophageal adenocarcinoma.
Forward flow of gastric contents reduces the pressure and reduces the opportunity for reflux. In normal mice the stomach is mostly empty between meals but is nearly full in LPS-treated mice (38). The LPS-delayed gastric emptying can be blocked by NS398 which is a selective COX-2 inhibitor (38). Thus, by reducing gastric emptying the type II microbiome might cause an increase in the intragastric pressure that contributes to the development of gastroesophageal reflux.
The type II microbiome could serve as a marker as well as an important target of intervention in clinical practice. If proven to play a critical role in disease progression from reflux esophagitis to esophageal adenocarcinoma, the use of the type II microbiome as a biomarker might help to better stratify reflux esophagitis and Barrett's esophagus patients into high vs. low risk groups which would improve the sensitivity as well as specificity of a surveillance strategy for early detection of esophageal adenocarcinoma. Furthermore, the cancer risk may be reduced by reversion from the type II microbiome to type I microbiome with the use of selective antibiotics or probiotics.
Because its association with a number of inflammatory and neoplastic diseases, the NF-κB pathway has been the target of drug development (39). Several drugs have been reported to block the pathway at various steps and their clinical use has been described (40–41). Many of these inhibitors could be effective in reduction of inflammation caused by NF-κB activation in reflux disorders. Drugs that are currently used in treating inflammatory diseases, such as glucocorticoids, nonsteroidal anti-inflammatory drugs, sulfasalazine, immunosuppressive agents (cyclosporin A and tacrolimus) often interfere the NF-κB pathway at multiple steps (Figure 1). Since they interfere with normal cellular function necessary to mount immune responses, inhibitors of NF-kB may also cause significant side effects such as increased susceptibility to infections, and liver dysfunction. Although limited by clinical side effects, interest remains in the therapeutic potential of NF-kB inhibitors to halt the metaplastic progression of Barrett's esophagus or to treat esophageal adenocarcinoma by inhibiting inflammation. Curcumin (diferuloylmethane) a naturally occurring NF-kB inhibitor was recently shown to increase apoptosis in two esophageal adenocarcinoma cell lines and to enhance their sensitivity to chemotherapeutic agents (42).
iNOS has been an attractive drug target as it is related to a variety of human diseases (43–46). Although L-canavanine, a selective iNOS inhibitor present in alfalfa can block the LPS-induced lower esophageal sphincter relaxation in rodents (34), its relationship with lupus-like autoimmunity limits its direct use in humans (47). The prodrug L-N6-(1–iminoethyl)lysine 5-tetrazole amide (SC-51), another selective iNOS inhibitor causes marked suppression of exhaled breath NO levels both in healthy control subjects and in patients without significant side effect (48). It may have therapeutic potential for controlling reflux/microbiome-induced esophageal inflammation.
COX-2 selective inhibitors represent a form of non-steroidal anti-inflammatory drug, such as Aspirin, that directly targets COX-2, an enzyme expressed in inflammation of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma (Figure 1). Ingestion of non-steroidal anti-inflammatory drug decreases the inflammatory complications of gastroesophageal reflux disease (49) and may reduce the risk of neoplastic progression in patients with Barrett's esophagus (50–51). Thus, aspirin and other non-steroidal anti-inflammatory drug could protect against esophageal adenocarcinoma by either preventing the development of its primary precursor (i.e., Barrett's esophagus) or by diminishing the likelihood of Barrett's esophagus progressing to esophageal adenocarcinoma. The mechanism of potential risk reduction is related to these agents' inhibition of the COX-2 enzyme, which is expressed in reflux esophagitis and Barrett's esophagus and is induced early in the development esophageal carcinomas. Like NF-kB inhibitors, COX-2 inhibitors represent a potential therapeutic option in controlling reflux/microbiome-induced esophageal inflammation which might trigger a progressive cascade to esophageal adenocarcinoma.
With these data, we can speculate the roles of the type II microbiome in the diseases of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. The type II microbiome with stepwise increase in Gram-negative bacteria in the reflux esophagitis - Barrett's esophagus and probably in esophageal adenocarcinoma could contribute to carcinogenesis by induction of chronic inflammation and cause gastric reflux by induction of abnormal relaxation of the lower esophageal sphincter and increase in intragastric pressure by delaying gastric emptying. These pathological effects could be explained in part by the activation of LPS/TLR4/NF-kB pathway. The type II microbiome could be used as novel biomarkers for risk assessment in clinical management. Antibiotic/probiotic treatment could reverse the type II microbiome back to the type I microbiome and decrease the detrimental effects of Gram-negative bacteria on LPS/TLR4/NF-kB pathway. The negative effects could also be alleviated using specific inhibitors to NF-kB and/or the downstream components, such as COX-2 and iNOS.
Supported by grants from the National Cancer Institute and the National Institute forAllergy and Infectious Diseases UH3CA140233, R01CA159036, R01AI063477,U19DE018385, K23CA107123, as well as the RWJ Amos Medical Faculty Development Program.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Now that we have our Discussion Forum completely set up, let's say it's the first week of our term. We want to make this Discussion Forum available to our students. So, on the left-hand column we can go ahead and click the Edit Settings option for this forum. We can scroll down to the bottom of the page and simply change the Visible setting from Hide to Show, then click the Save and return to course button. We are taken back to Week 1, let me go ahead and scroll down on the page, we can see that the Discussion Forum is now available to our student, hit the Move right button to move it into the proper place.
Now let's go ahead and logout of Moodle, by going back up to the top of our screen and clicking the Logout button, and then let's log back in as a student. Click the Login link, type in the Username Al and the Password of 12345. Hit the Login link, and now we are back in as the student. Go ahead and go back into course, Coral Reef Ecology and scroll down to the bottom of Week 1. here we can see the Week 1 Discussion Forum. Go ahead and click on that forum and this is what students would see, they would see the instructions they we have provided to them and they would see the initial four questions that they have been prompted with.
We can go into the first question by clicking on the link for question 1, and now we can read what that question says. Well, let's go ahead and make a response. So hit the button on the right that says Reply and then for response, we will simply type in Bermuda is an example of an island with coral reefs and is found outside of the 30N and 30S Range. Go ahead and scroll down on the forum and here the students get the same set of options that we do.
As a student they can choose to receive the emails for the postings or not. I will go ahead and leave it to set to Send email copies of this forum to me, so then as the student, I will be able to get the responses that somebody may respond to this particular forum, so I would know when to come in and start making additional responses. Hit the button for Post to forum and we are given a confirmation that the posting went on. Now when the page reloads, we can see the initial posting, and then we can see our response listed underneath of it. We can choose how we want the responses to look. initially, they're displayed in a Nested form.
We can also choose to display them as a Threaded form, where the initial posting is made and then any additional responses are listed underneath, we could choose to also look at them as a flat file with the newest first, so that the newest postings would be the first things that we see as additional postings are made,, or we can choose to see the oldest first. I like to look at these as a nested form, so that any responses to this question would show up tabbed underneath, whereas, additional responses to the initial posting would show up at the same level.
It just helps to keep things organized. Okay, now we know what the student sees. Let's go ahead and logout of the students view and log back in as our view. So back up to the top and click on the link for logout, then login again, logging in as yourself, I am going to login as Chris, my Password is 12345. I will back into My course, by clicking on the Coral Reef Ecology link, and now I can scroll back down to the bottom of Week 1 and here I am given feedback directly inside of my course to where I see that there's one unread post that I haven't read, that's related to this forum. This is great! A student made a posting in here and without even going into the forum.
I know that I already have something to read. I can go ahead and click on the Discussion Forum, and I can see that I have got one item that's been unread in this particular forum. I can go straight to that message by clicking on the number 1 and I can keep track of what's going on in the Discussions as they're happening by my students. Let's go ahead and return back to our course by clicking on BIOL432 in the breadcrumbs. Discussion Forums are a fantastic way to keep your students involved and engaged in your course material.
- Installing and configuring Moodle
- Creating assignments students can complete online
- Posting instructions on the course home page
- Messaging students
- Configuring Dropbox, Google Docs, Flickr, and YouTube repositories
- Creating a custom course web page
- Building a live chat room
- Designing surveys
- Setting up course-specific glossaries
- Seeding a forum with questions
- Creating a wiki for students to contribute content
- Developing multimedia exams to assess course comprehension
- Handling course administration and settings
- Backing up and restoring a course
- Importing a Moodle 1.9 course into Moodle 2


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mass spectrometer Equipment in Greece
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Agilent - Model 7000 Series - Triple Quadrupole GC/MS Systemby Chromtech Analytical Instruments GmbH Distributor in Xaladri, GREECE
The Agilent 7000B Quadrupole GC/MS/MS is the latest addition to Agilent's MS portfolio. Scientists performing "target compound analysis" in SIM mode on complex samples will find many ways to use its increased selectivity and sensitivity. MS/MS reduces sample prep, shortens analysis cycles, eliminates false results, and simplifies ...
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The Impactor Inlet is an accessory for the Aerodynamic Particle Sizer® (APS™) spectrometer. It combines a single-stage impactor with a filter to take a size-segregated sample. It then directs a small, representative sample of the initial test aerosol (diluted at 80 to 1) into the APS spectrometer for size-distribution measurement. The ...


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Candidate Giuliani to Return to Ground Zero on 9/11
Former mayor and president hopeful Rudy Giuliani will return to Ground Zero on the 6th anniversary of 9/11 and read from a text, Mayor Bloomberg told WCBS radio on Tuesday morning.
A spokesman for Bloomberg said the text has not yet been chosen. Each year, a different group of readers recite the names of the 2,749 people killed at the World Trade Center on 9/11, interspersed with readings from public and elected officials.
In past years, parents, siblings, and spouses have read the names. This year, firefighters, police officers and other rescue workers will read the list, which takes about four hours.
One sure bet is that Giuliani won't be reading a passage from "Rudy Giuiliani's Five Big Lies About 9/11". But if he were to read that article, a good might passage might be about weekends with Judi Nathan at his command center at 7 World Trade Center. You know, the command center with the humidor and monogrammed towels.
Wayne Barrett reported:
The mayor was so personally focused on the siting and construction of the bunker that the city administrator who oversaw it testified in a subsequent lawsuit that "very senior officials," specifically including Giuliani, "were involved," which he said was a major difference between this and other projects. Giuliani's office had a humidor for cigars and mementos from City Hall, including a fire horn, police hats and fire hats, as well as monogrammed towels in his bathroom. His suite was bulletproofed and he visited it often, even on weekends, bringing his girlfriend Judi Nathan there long before the relationship surfaced. He had his own elevator. Great concern was expressed in writing that the platform in the press room had to be high enough to make sure his head was above the cameras. It's inconceivable that the hands-on mayor's fantasy command center was shaped—or sited—by anyone other than him.
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Syriatel leading the Syrian mobile telecommunication market since 2000, we have successfully established our reputation by focusing on Customer satisfaction and social responsibility.
www.syriatel.sy GENERAL INFORMATION
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[Querying whois.internic.net] [whois.internic.net] Whois Server Version 2.0 Domain names in the .com and .net domains can now be registered with many different competing registrars. Go to http://www.internic.net for detailed information. No match for domain "SYRIATEL.SY". >>> Last update of whois database: Wed, 13 Apr 2016 10:32:25 GMT <<< NOTICE: The expiration date displayed in this record is the date the registrar's sponsorship of the domain name registration in the registry is currently set to expire. This date does not necessarily reflect the expiration date of the domain name registrant's agreement with the sponsoring registrar. Users may consult the sponsoring registrar's Whois database to view the registrar's reported date of expiration for this registration. TERMS OF USE: You are not authorized to access or query our Whois database through the use of electronic processes that are h electronic processigh-volume and automated except as reasonably necessary to register domain names or modify existing registrations; the Data in VeriSign Global Registry Services' ("VeriSign") Whois database is provided by VeriSign for information purposes only, and to assist persons in obtaining information about or related to a domain name registration record. VeriSign does not guarantee its accuracy. By submitting a Whois query, you agree to abide by the following terms of use: You agree that you may use this Data only for lawful purposes and that under no circumstances will you use this Data to: (1) allow, enable, or otherwise support the transmission of mass unsolicited, commercial advertising or solicitations via e-mail, telephone, or facsimile; or (2) enable high volume, automated, electronic processes that apply to VeriSign (or its computer systems). The compilation, repackaging, dissemination or other use of this Data is expressly prohibited without the prior written consent of VeriSign. You agree not to use electronic processes that are automated and high-volume to access or query the Whois database except as reasonably necessary to register domain names or modify existing registrations. VeriSign reserves the right to restrict youservesr access to the Whois database in its sole discretion to ensure operational stability. VeriSign may restrict or terminate your access to the Whois database for failure to abide by these terms of use. VeriSign reserves the right to modify these terms at any time. The Registry database contains ONLY .COM, .NET, .EDU domains and Registrars. T, .EDU do
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Lady Gaga, Kanye West Get Woman, Man Of The Year Celeb Support
MTV News hit the red carpets to find out who the stars would pick for 2010.
MTV News has been counting down the top five men and women who've had the biggest 2010, honoring the likes of [article id="1654070"]Lil Wayne[/article], [article id="1654195"]Drake[/article], [article id="1654291"]Justin Bieber[/article] and [article id="1654391"]Eminem[/article] on the men's side, and on the ladies' side [article id="1654073"]Nicki Minaj[/article], [article id="1654190"]Snooki[/article], [article id="1654290"]Taylor Swift[/article] and [article id="1654388"]Katy Perry[/article] made the cut. Then on Friday (December 17), we announced the prestigious #1s: [article id="1654467"]Lady Gaga[/article] and [article id="1654470"]Kanye West[/article].
But we know you don't just want to take our word for it, so we asked some of your favorite celebrities who they thought the man and woman of 2010 were.
Woman of 2010
Katy Perry (our #2) got a few votes, and the Situation went for Taylor Swift (our #3). Michael Bublé chose Pink; while Pauly D said the year was all about Kim Kardashian.
NKOTB's Joey McIntyre got all political and suggested, "Hillary Clinton, man. She's in a load of trouble with all those leaks."
Jay Sean made a case for his pal Nicki Minaj (our pick for #5), saying, "I think it had to be Nicki's year. She had a great, great year."
But in the end most agreed that Gaga ruled 2010.
"Woman would have to be Lady Gaga," Taio Cruz said. "I'm sure that's a unanimous decision."
Mark Hoppus added, "Lady Gaga just cause you can't stop talking about her."
Man of 2010
Mark Hoppus also agreed with our pick for Man of the Year, showing some love for Kanye West. But our unofficial celebrity poll remained inconclusive in this category. Paramore's Hayley Williams chose Conan O'Brien. Drake and Eminem got a couple of co-signs, as did Justin Bieber, Russell Brand.
"I'd probably vote for myself," B.o.B not-so-humbly shared. "Bob!"
Usher (whose [article id="1653969"]"OMG" is MTV News' #1 Song of the Year[/article]) got some love from Nelly and Jesse McCartney, who shared, "Because there were a lot of redemptive qualities to this album."
But leave it to Rosie O'Donnell to make a case for the one and only Stefani Germanotta as Man of the Year. "Lady Gaga," she said. "Yes, indeed and she'll kick your ass if you say she doesn't deserve it [and] rightly so."
Head over to the Newsroom blog to vote in our Man and Woman of the Year polls, and give us your write-in votes in the comments!


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Research overview
Contact between unrelated languages is my core area of interest, including both language-internal and sociolinguistic changes that arise from contact.
Language maintenance and shift
My dissertation will look at language choice from generation to generation in Inner Mongolia, China. Part of the study design is shown in these slides from the 2014 Urban Linguistics Seminar conference in Hohhot. Preliminary results are shown in this poster from the 2015 New Ways of Analyzing Variation (NWAV) conference in Toronto. The committee consists of Professors Sharon Hargus (chair), Stevan Harrell, Richard Wright and Betsy Evans.
Phonology of languages in contact
In 2011 I made some field recordings to investigate the phonological adaptation of Chinese and Russian loanwords into different dialects of Modern Mongolian. That work is briefly documented in these slides from my presentation at the workshop on "Loanwords as evidence in formal linguistics" at the 2012 annual meeting of Societas Linguistica Europaea, and extensively documented in my 2013 MA thesis.


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Loudmouth Releases Special Edition Mustache Pant
FOSTER CITY, CA--(Marketwired - September 28, 2016) - Mustache enthusiasts get ready, Loudmouth has launched their brand new mustache pant and they're so distinguished they'll make even the most...(more)
Loudmouth Golf
Sep 28, 2016 08:00 ET
mCig, Inc. CEO to Retire 50 Million Underlying Common Shares of Company Stock to the Company Treasury
HENDERSON, NV--(Marketwired - Sep 28, 2016) - mCig, Inc. (OTCQB: MCIG), a diversified company servicing the legal cannabis, hemp, and CBD markets, announced today its Chairman and CEO, Paul...(more)
mCig, Inc.
Sep 28, 2016 07:00 ET
Dr. Rao of Diet Doc Believes That Even Natural Diet Pills Should Be Used Under Medical Supervision
HATTIESBURG, MS--(Marketwired - September 28, 2016) - With the evolution of increasingly sedentary lifestyles and tons of conflicting information regarding which diets are best for weight loss...(more)
Diet Doc Weight Loss
Sep 28, 2016 01:00 ET
Working Mother Names BCG One of Its 100 Best Companies for the Ninth Time
BOSTON, MA--(Marketwired - Sep 27, 2016) - Working Mother magazine has named The Boston Consulting Group (BCG) one of its "100 Best Companies" for US working moms for the ninth time.
Boston Consulting Group
Sep 27, 2016 16:00 ET
Astavita Brings AstaMed(R) MYO, Prescription Medical Food for Clinical Dietary Management of Sarcopenia, Into Symplmed DyrctAxess Technology(R)
BELLEVUE, WA--(Marketwired - Sep 27, 2016) - AstaMed, a division of Astavita, Inc., and a biotech leader in the development and commercialization of natural astaxanthin prescription medical...(more)
Sep 27, 2016 15:48 ET
Whistler Medical Marijuana Corporation (WMMC), a Certified Organic Licensed Producer of Medical Cannabis, Today Announced the Release of Canada's First High Cannabigerol (CBG) Cannabis Oil
WHISTLER, BC--(Marketwired - September 27, 2016) - The release follows two years of research identifying the best medical phenotypes from the diverse seed bank at WMMC. The process identified a...(more)
Whistler Medical Marijuana Corp
Sep 27, 2016 13:49 ET
Borislow Insurance Named a 2016 WWCMA WorkWell Massachusetts Silver Level Winner for Exemplary Worksite Health Promotion
METHUEN, MA--(Marketwired - September 27, 2016) - Borislow Insurance is proud to have been named a WorkWell Massachusetts Award Program Silver Level winner for exemplary worksite health promotion....(more)
Borislow Insurance
Sep 27, 2016 12:49 ET
Janrain Adds WeChat to Its Growing List of Identity Providers
PORTLAND, OR--(Marketwired - September 27, 2016) - Janrain®, the leading Customer Identity and Access Management (CIAM) solutions provider, today announced it has added WeChat to its growing list...(more)
Sep 27, 2016 09:00 ET
Viveve Submits Investigational Device Exemption (IDE) for VIVEVE II
SUNNYVALE, CA--(Marketwired - September 27, 2016) - Viveve Medical, Inc. ("Viveve") (NASDAQ: VIVE), a medical technology company focused on women's health, today announced submission of an...(more)
Viveve Medical, Inc.
Sep 27, 2016 08:02 ET
U.S., Switzerland, U.K., China Are Top Hotspots for Wearable Electronics Innovation
BOSTON, MA--(Marketwired - September 27, 2016) - Even though the United States remains the dominant innovation hub for wearable electronics, a number of other countries have emerged with varying...(more)
Lux Research
Sep 27, 2016 07:30 ET


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Judge: Ex-Probation Commish O'Brien can attend daughter's wedding
Credit: AP
Indicted ex-Commissioner of Probation John "Jack" O'Brien got the green light today to attend his youngest daughter's wedding Dec. 28, along with a warning from the sentimental judge not to mix business with pleasure as he celebrates with former colleagues who may be named as witnesses at his trial.
U.S. District Court Judge F. Dennis Saylor IV said in his decision he would not restrict the guest list, but cautioned O'Brien, 56, of Quincy, he is "not to discuss his pending criminal charges, or possible trial testimony, with any such individuals in their presence."
The Herald reported Monday O'Brien was asking to modify the conditions of his pre-trial release for the event since those restrictions include that he is forbidden to fraternize with past and present Probation Department workers, some of whom are family friends and were invited to his daughter's weddnig.
Federal prosecutors filed paperwork today objecting in part, saying they were fine with O'Brien going to the wedding so long as the guest list excluded anyone he planned to call as a defense witness.
The feds also pointed out that the groom is a current Probation department employee who was hired by O'Brien, and his future father-in-law's trial is scheduled to get underway Feb. 24.
Saylor, however, did not place any restrictions, beyond asking O'Brien not to discuss matters related to the charges against him.
O'Brien, his former First Deputy Commissioner Elizabeth Tavares and former Deputy Commissioner William Burke III are charged with racketeering, conspiracy and mail fraud charges in connection with an alleged patronage scheme to give jobs and promotions to sometimes-unqualified individuals backed by high-level politicians with the ability to influence how much funding their department received from legislators.


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text: Even though we were a tad early (1.30pm), our room was ready. The car park is accessed through a carriageway from the street and is able to be locked by a gate at night. Room 21 is a ground floor room in what others have called "the annex", but is really just that part of the hotel which is accessed... More


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Come and discover our last minute hotel offers Venice.
Display the best hotel promotions Mirano.
Park Hotel Villa Giustinian proposes special offers on the occasion of events, trade fairs and special celebrations, special packages including admission to the major funfairs and advantageous last minute offers for those flocking to Venice to spend pleasant holidays here.
25 April 2016
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• Stay in a double room
• Breakfast Buffet
• Welcome Drink
• 2 free drinks
• 1 map of Venice and its surroundings with itineraries
• city-bike (subject to availability)
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• VAT and taxes included
EUR 40.00 per person
1° May 2016
2 June 2016
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Stay in double room;
Buffet breakfast;
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Loungers and pool towels;
Rent a city-bike (subject to availability);
2 free drinks from the minibar;
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Free wi-fi in the room;
Inside parking available;
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Package price 3 nights: Euro 119.00 per person.
Offer available from 01/06 to 05/06


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text:
The final play was supposed to be a slant pass. When it became more of a fade toss to the right corner of the end zone, Jordan Neely made a quick-thinking adjustment.
The senior wideout's clutch touchdown grab with no time remaining lifted host Abington, which trailed most of the way, to a thrilling, 35-34 nonleague victory over Northeast in the season opener for both squads Friday at Schwarzman Stadium.
On the play that started with two seconds to go, the 5-foot-10, 155-pound Neely went up against two Northeast defenders and hauled in the 5-yard throw from quarterback David Kretschman.


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Home > Sunglasses > Smith > WAYWARD/N (DL5/W5)
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text:
Smith has not received any new offers and is at the point in his recruitment where he is looking at several schools. "I will start doing things like talking to the coaches more and setting up visits to get to know more about them."
Eric has six schools that he feels are recruiting him the hardest. The six are Georgia Tech, Ohio State, Michigan, Tennessee, Louisville, and Indiana. "All of them are ones I like very much and I will take the time and effort to get to know as much as I can about each."
Even though Georgia Tech is the furthest away, Smith doesn't look at that as a negative. "My teammate Marshon Lattimore and I plan on making a trip down to Georgia Tech on our own just to check them out." The Glenville teammates want to get to know the school, city, campus, coaches, and players better. "The best way to do that is to make a trip on our own."
Smith and Lattimore visited Tech last season. "We really loved it and it made us want to come back for another visit this summer. We might even come back for another game this year."
Coach Walkosky and Smith have stayed in touch since his visit to Tech last season. "He told me that he has moved back to coaching special teams but I am still a high priority."
The summer tour for Smith and his teammates will include Georgia Tech, Tennessee, Louisville, and Kentucky. "I know a lot of us will crowd into a van and go on a road trip." The teammates may include additional schools if they have the time.


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SpongeBobs Pizza Toss
Help SpongeBob SquarePants deliver pizzas to all the hungry customers in Bikini Bottom! You're on your delivery bike in this fast-paced pizza throwing game! Your job is to get the pizzas to the customers, avoid the people in the streets and grab powerups (like the ones that give you more pizzas) as you go! Use the arrow keys to avoid pedestrians, and spacebar and the CRTL key to throw those pizzas high and low. Some customers want their pizza at the front door; others want it on the second floor while reaching out the window!
SpongeBobs Pizza Toss Fullscreen
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Your Annual Home Tech Maintenance Checklist
Once a year, using your birthday or some other milestone as a reminder, go through your home tech and give it a little love. Things will work better, last longer and keep you comfortable and safe:
- Unblock the AC. Take the vents off your A/C unit and give them a good deep clean to clear up anything that's blocking your flow.
- Clean fridge coils. Save yourself nearly 6 percent on your utility bills by scrubbing down those cooling coils behind (or under) your refrigerator.
- Test your smoke detector. You're supposed to do it more frequently, but you should test your smoke detector and change its batteries at least annually.
- Backup your computer. I'll admit I don't do this every few months as suggested. If you're a backup slacker like me, at least make it part of your birthday checklist.
- Flush your garbage disposal. Send a little warm water and baking soda down your garbage disposal to clean it out. Add a little lemon peel if there's an odor.
- Vacuum your clothes dryer. Go heavy-duty with the lint trap and vacuum up any open ducts or hoses.
- Glance at your hidden wires. You do such a good job of hiding wires that you might not see if they need to be replaced or repaired. Check behind the TV or desk for old, frayed cords.
- Deep clean your switch plates. Nothing else in your house gets as much action. Use your birthday as a reason to pull off each light switch plate in your house and (carefully!) wipe everything down.
(Images: Flickr member Karin Biel licensed for use under Creative Commons, DIY Network)


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RICFest Homecoming Update: All outdoor activities planned for Oct. 1 have been moved indoors. Click here for details.
- About RIC
- Academics
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Campus Life
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- About The RIC Foundation
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The Gold and White Society
Please consider joining the Gold and White Society. You can become a member by notifying the Office of College Advancement that you have made a provision in your will to benefit the college. A list of current member is available in our Annual Report of Gifts.
Page last updated: Friday, February 15, 2013


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2015 National Award Winning Cheese. Traditional farmstead cheese making methods are used to create fresh chevre. We make cheese in small batches with special attention to details which results in a mild, rich cheese complemented with organic seasonings. our cheese »
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Queen of the herd, Ethel is dependable and gives over 1-1/2 gallons of milk per day. She and her sister Lucy (with whom she is inseparable) are always the first ones in the milking line. Ethel is one of our original girls and her steady delivery and even temperament are celebrated this month. She is a purebred Saanen, which are the Holstein's of the goat world. At 5 years old, she is only 1/2 way thru her dairy productive life. Go Ethel Barrymore Milk! about our goats »


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Governor Brewer Nominates Former House Speaker Mark Killian to Board of Regents
Governor Jan Brewer announced today her nominee to fill a spot on the Arizona Board of Regents.
Mark Killian, former speaker of the Arizona House of Representatives, got the nod from Brewer and would replace Robert Bulla, whose term expires this year.
"Mark is a well-known and highly regarded public leader who understands the critical role that education serves in my priorities of job growth and business recruitment," Brewer says in a statement.
Killian is a Mesa resident who served as speaker for four of his 14 years in the Legislature. He also served for nearly six years as former Governor Fife Symington's director of the Department of Revenue.
Upcoming Events
NBA Preseason: Phoenix Suns vs. San Antonio Spurs
TicketsMon., Oct. 3, 7:00pm
NBA Preseason Basketball: Phoenix Suns v. Utah Jazz
TicketsWed., Oct. 5, 7:00pm
Arizona Coyotes vs. San Jose Sharks
TicketsFri., Oct. 7, 7:00pm
Monster Jam
TicketsSat., Oct. 8, 7:00pm
Regents are volunteers. The organization governs Arizona's three universities and plays a major role in the cost of tuition, so being a member isn't some cushy, do-nothing job -- there's real potential to piss off a lot of people.
The gig isn't Killian's just yet, though. Before it's official, Killian must be confirmed by the state Senate, which shouldn't be a problem -- the guy's a Republican who spent roughly 20 years in state government. He's bound to have a friend or two in the Senate.
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