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Home > Eyeglasses > Jil Sander > J4006 (B)
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J4006/B Eyewear
The term "visual aid" is unsuitable for J4006. This is an accessory that ushers in a new you, emphasizing your clear view on fashion. The new Jil Sander underlines that you are a trendsetter. For the current season the renowned label sets the standards with its collection for 2016. The J4006 is available in the Edel-Optics online shop in other styles from Jil Sander collections 2015 and 2016.
This Jil Sander model is an all-rounder, equally suiting men and women. Wearing full rim eyewear, you make it unmistakably clear that you are going the whole hog. Plastic frames like these combine durability and are comfortable to wear. The J4006 is a very snug fit on the ears and nose. Whether natural or extravagant - the colour green makes you stand out from the crowd and makes your eyeglasses the perfect accessory.
With the help of our digital dispensing optician, your prescription lenses can be configured according to your own requirements. Anti-reflective and cleaning coatings, antistatic and lotus effect are included as standard for plastic lenses.
Even if this Jil Sander is presently not in stock, it is worth ordering now, because the current price can't be beaten. And because Edel-Optics is a paradise for bargain hunters, you can get this top model at an incredibly low price. What is labelled as "in the sale" at other online shops, is for us "all-day-everyday" prices.
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At Paris Fashion Week all three houses offered exhilarating collections that were a heady exploration of creative unsettling.
The seafaring life was the inspiration for Clare Waight Keller's lovely, breezy spring collection for Chloé.
Advertising technology firm Pixability found brand-generated digital content is falling behind the content produced by individual creators.
Sally Beauty chief financial officer Mark Flaherty unexpectedly resigned.
Von Mueffling, a former beauty editor, runs her own health and beauty web site called Beauty and Well Being.
The executive previously headed Laura Mercier, which was recently acquired by Shiseido.
Currently at Henkel, Rauch will join the parent company of the German perfumery chain early next year.
The fellowship honors female scientists at critical stages of their careers with $60,000 grants to advance their postdoctoral research.
Ingredient story fueling growth of line based on traditional Chinese medicine.
Pontes returns to Lauder from a role with Swarovski.
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Each finalist will have the opportunity to present at L'Oréal USA's internal marketing conference.
The brand has a new chief financial officer, head of operations, head of product development and sourcing manager.
The beauty brand was acquired by Tengram Capital in August.
The Duke sophomore will unveil her rebranded planner business in a few weeks, she said.

subset: commoncrawl


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VistaGen Therapeutics (VSTA) Awarded U.S. Stem Cell Technology Patent Covering Methods Used To Test Drug Candidates For Liver Toxicity 0 commentsApr 25, 2012 2:31 PM | about stocks: VTGN
VistaGen Therapeutics, Inc., a biotechnology company applying stem cell technology for drug rescue, just announced it has secured a new United States patent covering the company's proprietary methods used to measure and type the toxic effects produced by drug compounds in liver stem cells.
Test methods included in this new patent, (U.S. Patent 11/445,733), titled "Toxicity Typing Using Liver Stem Cells," cover all mammalian liver stem cells, including human cells. Liver stem cells used in drug testing can be derived from in vivo tissue or produced from embryonic stem cells (NYSE:ES) or induced pluripotent stem cells (iPS).
H. Ralph Snodgrass, Ph.D., VistaGen's President and Chief Scientific Officer, stated, "This patent covers the monitoring of changes in gene expression as an assay for predicting drug toxicities. It is well known that drugs activate and suppress specific genes, and that the changes in gene expression reflect the mechanism of drug toxicities. The specific sets of genes that are affected become a profile of that drug."
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Please see disclaimer on the MissionIR website http://www.missionir.com/disclaimer.htmlStocks: VTGNBack To MissionIR's Instablog HomePage »
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Marine & Ocean Sciences Blog
Marine & Ocean Sciences Blog
Mar 10, 2016
3 UNH Faculty Receive NSF Faculty Early Career Development (CAREER) AwardsThree UNH faculty members have received prestigious National Science Foundation (NSF) awards to support work that aims to understand turbulent flows, a unique category of honeycomb-shaped materials, and flexible biomolecules. John Gibson, assistant professor of mathematics, Yaning Li, assistant professor of mechanical engineering and Harish Vashisth, assistant professor of chemical engineering... Read more
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UNH Experts Express Their Hopes for the United Nations' Climate Summit in ParisLeaders from across the globe convened in Paris for COP21, the United Nations' climate summit, where they are worked toward a "strong climate agreement." UNH experts with a range of perspectives shared their insights and discussed what they hope to see come out of COP21. Full story Read more
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 4, 1978
|Filing date
|Oct 19, 1976
|Priority date
|Oct 31, 1975
|Also published as
|Publication number
|Syoichi Kikumoto, Osamu Yamamoto, Nobuhiko Komatsu, Haruhiko Kobayashi, Teruo Kamasuka
|Original Assignee
|Taito Co., Ltd., Kaken Chemical Co., Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Non-Patent Citations (1), Referenced by (3), Classifications (9)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to Neoschizophyllan of a novel polysaccharide and the process for producing Neoschizophyllan.
Neoschizophyllan can be obtained by an ultrasonication of Schizophyllan.
Schizophyllan is a polysaccharide having antitumor and antibacterial action which can be obtained by extracting and purifying a culture solution of Schizophyllum commune Fries which belongs to Basidiomycetes or a fruit body thereof.
The structure, manufacture and antitumor action of Schizophyllan have been disclosed in GANN 60, p. 137 to 144 (1969) and Japanese Journal of Antibiotics 26, p. 277 to 283 (1973) and U.S. Pat. No. 3,943,247 as well understood the structure, manufacture and antitumor action of Schizophyllan. Accordingly, in the specification, the description is not recited and the disclosures should be considered those of U.S. Pat. No. 3,943,247 and the journals.
Schizophyllan has excellent antitumor action as disclosed in the prior arts, however, Schizophyllan is sparingly soluble in water and an aqueous solution of Schizophyllan has high viscosity. Accordingly, when orally administered, the absorption of the Schizophyllan is very poor, whereby the antitumor action is not substantially found.
In order to give desired therapeutic effect, it is necessary to administrate a large amount of a dilute solution of Schizophyllan and accordingly, it is difficult to administrate Schizophyllan to human body by an injection.
In the subcutaneous injection or the intramuscular injection of Schizophyllan, the local pain and induration are caused. In the intravenous injection of Schizophyllan, the occulsion of blood-vessel and other troubles are caused in the circulatory system.
Accordingly, Schizophyllan could not be used as a medicine.
It is an object of the invention to provide a novel polysaccharide of Neoschizophyllan which has low viscosity in the form of an aqueous solution and which can be applicable for therapeutic purpose.
Another object of the invention is to provide a novel polysaccharide of Neoschizophyllan which has low toxicity as an injectable solution.
The object of the invention is to provide a novel polysaccharide of Neoschizophyllan which can be absorbed by an oral administration.
These objects of the present invention have been attained by an ultrasonication of Schizophyllan.
In order to obtain polysaccharides having antitumor effect without the above-mentioned disadvantages, the inventors have studied many derivatives and degraded products of Schizophyllan. As the result, novel degraded product of polysaccharide which has not the above mentioned disadvantages and has pharmacological activity which is the same or higher than that of Schizophyllan and has low toxicity and low viscosity in a form of an aqueous solution can be obtained by the ultrasonic treatment of Schizophyllan. The novel polysaccharide is called as Neoschizophyllan in the nomenclature. According to the analysis of the ultracentrifugation, the gel filtration and high voltage electrophoresis, Neoschizophyllan gave a single peak whereby it was confirmed to be a homogenous compound.
The basical structure of Neoschizophyllan is considered as the same with that of Schizophylan as shown in the formula I. ##STR1##
The molecular weight of Neoschizophyllan varies depending upon the methods of measurement as those of polymers.
In accordance with the Park-Johnson method, the molecular weight of Schizophyllan is 20,000 to 60,000 while the molecular weight of Neoschizophyllan is 1,500 to 4,000.
In accordance with the ultracentrifugation Schlierene pattern method, the molecular weight of Schizophyllan is 150,000 to 2500,000 while the molecular weight of Neoschizophyllan is 300,000 to 700,000.
The pharmacological properties of Neoschizophyllan are remarkably different from those of Schizophyllan.
The toxicity of Neoschizophyllan is remarkably low comparing with those of Schizophyllan. For example, LD50 (i.v.) of Schizophyllan is 30 mg/kg whereas LD50 (i.v.) of Neoschizophyllan was 718 mg/kg.
As shown in the following Test 1, the optimum dose of Schizophyllan is more than 2 mg/kg whereas the optimum dose of Neoschizophyllan is less than 2 mg/kg for showing the best effect.
When Schizophyllan is chemically or enzymatically degraded with an acid or an enzyme, the pharmacological effect is decreased and in most cases, homogenous degraded product could not be obtained.
Accordingly, Neoschizophyllan is quite different from the degraded products produced by the chemical or enzymatic methods.
The physical properties of Neoschizophyllan are as follows.
1. White powder, no taste, no smell:
2. Basical structure: (stated above)
3. Molecular weight: (stated above).
In the Park-Johnson method, the condition of treatment for the measurement is severe whereby the molecules are cut in the treatment for measurement to increase the reducing terminals so as to be measured as smaller molecular weight. In the ultracentrifugation-Schlieren Pattern method, each molecular weight was given by the following equation <Mandelkern-Flory equation, J. Chem. Phys. 20, 212 (1952)>. ##EQU1## N = 6.023 � 1023 η = intrinsic viscosity
Schizophyllan 13 dl/g
Neoshizophyllan 6.45 dl/g
ηo = 0.01005 poise
ν = 0.55 ml/g (estimation)
ρ = 0.998 g/ml
S20, w; (See paragraph 8)
β; 2.16 to 2.4 � 106 (estimation)
4. Elementary analysis: No nitrogen: C/H ratio is about 6/1.
5. Intrinsic viscosity; 1 to 6 (dl/g); (Schizophyllan : 12 to 15 dl/g)
6. Relative viscosity; See FIG. 1.
7. [α]d 20 : see FIG. 1.
8. sedimentation coefficient: S20,w 3 to 7 (Schlieren pattern); (Schizophyllan 10 to 13)
proton-decoupled C-13 NMR spectrum of Neoschizophyllan (sonicated time 10 hrs.) at room temp. in alkali solution (0.5 N) (100 mg/2.5 ml).
Width 4,000 Hz, 8K data points, 26,190 accumulations, cyclic time 1.5 sec., pulse angle 45� .
______________________________________No. PPM Height(%)______________________________________1 104.331 12.1652 103.938 9.7353 87.551 4.1564 87.083 5.6825 77.173 16.4626 75.965 4.8587 74.442 19.1478 71.049 9.6079 70.113 5.34710 69.369 12.12211 61.997 15.595______________________________________
Proton-decoupled C-13 NMR spectrum of Schizophyllan at room temp. in alkali solution (0.5 N) (100 mg/2.5 ml).
Width 4,000 Hz, 8K data points, 35,963 accumulations, cyclid time 1.5 sec., pulse angle 45� .
______________________________________No. PPM Height(%)______________________________________1 104.368 17.7682 103.981 11.9813 87.629 7.7454 87.161 10.1325 77.173 21.7906 75.965 8.3377 74.520 23.2318 71.086 10.6459 69.410 17.11510 61.957 20.618______________________________________
10. Color reaction:
Negative for Iodine reaction; Positive for Molish, Phenolsulfuric acid, and Anthrone reactions:
11. Solubility:
One gram of Neoschizophyllan is completely dissolved in 9 ml of water after 10 minutes of stirring at room temperature whereas Schizophyllan remains undissolved even after 1 hour of stirring in the same condition.
12. LD50 (mouse)
______________________________________Neoschizophyllan Schizophyllan______________________________________i.v. 718 mg/kg 30 mg/kgi.p. >2000 mg/kg >250 mg/kg it is impossi- ble to give large dose.i.m. >100 mg/kg --s.c. >2000 mg/kg --p.o. >1000 mg/kg --______________________________________
The ultrasonication of the invention will be illustrated. It has been known to convert polymers to compounds having lower molecular weight by the ultrasonication.
The ultrasonication of dextran has been studied by M. Stacey and the ultrasonication of starch, agar, sodium alginate, chondroitin sulfuric acid and methyl cellulose has been studied by many researchers. [A. R. Lockwood et al., Research Supplement 4-I, Pages 46 to 48 (1951); M. Stacey ibid. page 48 (1951); A. Otsuka et al., Yakuzai gaku Vol. 26, pages 203 to 207 and 207 to 210 (1966); T. Tatsuhara and S. Iguchi ibid. Vol. 32, pages 86 to 95 (1972)] .
In the prior arts, the changes of viscosity and molecular weight of polymers by the ultrasonication and the mechanism of the ultrasonication have been discussed, however, the pharmacological activities and clinical toxicities of the products or the by-products have not been discussed.
It is possible to dissolve Schizophyllan in a hydrophylic organic solvent such as dimethylformamide and dimethylsulfoxide before the ultrasonication, however, it is preferable to dissolve it in water from the viewpoint of the use of the product.
The ultrasonication can be carried out in various conditions.
The output of the ultrasonication can be given by the equation:
W = 2 π2 ρ C(FA)2
W: output per unit area
ρ: density of solution
C: velocity of sound in solution
F: frequency
A: amplitude.
In the ultrasonication, the concentration of the solution of Schizophyllan is usually higher than 0.1 wt.% preferably higher than 0.5 wt.% When the concentration of Schizophyllan is high, Schizophyllan is not dissolved and the viscosity is high to decrease the effect of the ultrasonication. Accordingly, it is usually less than 5 wt.%.
In the ultrasonication, it is preferable to give a large amplitude i.e., 5 to 500 microns especially 10 to 200 microns under the frequency of 5 to 50 KHz preferably 8 to 30 KHz. It is preferable to give higher amplitude though a corrosion of a vibrating plate and other trouble of the apparatus may be considered in high amplitude. Wehn the frequency is too low, a noise is caused whereas when the frequency is too high, a desired amplitude cannot be given.
In the ultrasonication, the total output energy is usually 0.1 to 50 watt-hour per 1 cc especially 0.5 to 10 watt-hour per 1 cc of the solution of Schizophyllan. When the concentration of Schizophyllan is low, the total output energy can be lower.
It is preferable to recycle the solution in the ultrasonication so that the solution is uniformly contacted with the vibrating plate.
In the ultrasonication, it is preferable to select the shape of the vessel so as to efficiently and uniformly contact the molecules of Schizophyllan with the surface of the vibrating plate or to equip a desired stirrer.
The optimum conditions are dependent upon the concentration of Schizophyllan, the oscillating frequency, the output, the shape and size of the vessel and the stirrer. In usual, when 2 liters of 1.5% Schizophyllan solution is treated by the ultrasonication, it is enough to apply it at 500 W for 6 to 8 hours. When the amount of the solution and the concentration of Schizophyllan are increased, the time for ultrasonication may be prolonged proportional to the increases. When suspending particles are contained in the solution, the attenuation of energy should be considered. The time for ultrasonication should be prolonged when the stirring is not enough or bubbles are included into the solution.
When the energy of ultrasonication is too low, it is not enough to convert Schizophyllan to Neoschizophyllan whereby Schizophyllan and the poorly degraded Schizophyllan are remained. In the medical use, it is not always necessary to separate them when the amounts of the remained Schizophyllan and the poorly degraded Schizophyllan are small.
FIG. 1 is a graph showing the effect of the alkaline concentration of the viscosity and [α]D 20 of Neoschizophyllan. When the concentration of NaOH is higher than 0.1N, the relative viscosity and [α]D 20 are remarkably decreased. When the concentration of NaOH is higher than 0.2N, the relative viscosity and [α]D 20 are quite low.
FIG. 2 is a graph showing the viscosity characteristics of the solutions of Schizophyllan (0.23%) and Neoschizophyllan (1.13%) (Intrinsic viscosity-rotary speed r.p.m.).
The graph shows that the solution of Neoschizophyllan had low viscosity and was Newtonian liquid though the solution of Schizophyllan had high viscosity and was non-Newtonian liquid. The changes of the viscosity and Newtonian property are irreversible.
FIG. 3 shows the time course of changes in relative viscosity and molecular weight in the ultrasonication (the molecular weight of the product was measured by the Park-Johnson method). (0.1% Schizophyllan aqueous solution).
One of the advantages of the invention is to easily perform a membrane filtration of Neoschizophyllan. The membrane filtration must be carried out for a preparation of a medicine.
The characteristics of filtrations of Schizophyllan and Neoschizophyllan through a millipore filter are shown in Table 1.
The other advantages of the invention is to be able to prepare a solution having high concentration of Neoschizophyllan.
A maximum concentration of a solution of Schizophyllan is about 0.4% whereas it is easy to prepare 3 - 5% solution of Neoschizophyllan in the preparation of a medicine without any difficulty.
It is possible to prepare a medical solution having low viscosity and high concentration by using Neoschizophyllan, whereby the above-mentioned disadvantages of Schizophyllan in the preparation of a medicine can be satisfactorily prevented.
The most important advantage of the invention is to give a novel compound of Neoschizophyllan which has a pharmacological activity comparable to or even higher than that of Schizophyllan and has remarkably low toxicity.
Neoschizophyllan is absorbed into blood and tissues more rapidly than Schizophyllan.
Neoschizophyllan can also be used as an intermediate for various derivatives.
Neoschizophyllan of the invention can be administered by various methods such as oral administration, subcutaneous injection, an intramuscular injection and an intravenous injection.
Neoschizophyllan can be dosed in any desired form such as a tablet, a capsule, an injectable solution, a syrup, and the other pharmaceutical compositions.
Neoschizophyllan can be combined with the other antitumor medicine such as Mitomycin C, 5-Fluorouracil, 6-Mercapropurine, Cytosine-arabinoside, Bleomycin, etc.
A dosage of Neoschizophyllan is usually 0.005 to 100 mg/kg/day, preferably 0.05 to 2 mg/kg/day. A concentration of the injectable solution is preferably 0.05 to 4%.
Table 1__________________________________________________________________________Characteristics of filtration byMillipore filter: Number of Concentra- Time for filter- sheets of tion of solu- ing 1 liter of membranes Filtering tion solution used velocity__________________________________________________________________________No treatment 0.05 % 4.0 hour 3 83 ml/hr/cm2 0.10 % 10.0 hour 4 33 ml/hr/cm2 0.15 % difficult -- --Ultra-sonifi-cation 0.5 % 1 hour 0 330 ml/hr/cm2 1.0 % 2.5 hour 2 132 ml/hr/cm2 1.5 % 4.0 hour 3 83 ml/hr/cm2 2.0 % 10.0 hour 5 33 ml/hr/cm2__________________________________________________________________________ Note: Area of filtration 3.0 cm3 Membranes pretreatment membrane (AP 25), DA (0.65μ) HA (0.45μ), an the filtration at the same time.
The invention will be further illustrated by certain examples.
A 500 mg of polysaccharide of Schizophyllan powder which was produced by extracting and purifying a culture solution of Schizophyllum Commune Fries was completely dissolved in 500 ml of a hot water.
The solution of Schizophyllan was treated by the ultrasonication at the oscillating frequency of 20 KHz in an amplitude of 20 microns and the output of 100 W with stirring the solution so as to uniformly contact with the vibrating plate without incorporating bubbles.
After the ultrasonication for 60 minutes, the solution of Neoschizophyllan having the following properties was obtained.
The pharmacological activity of Neoschizophyllan was substantially the same with that of Schizophyllan.
______________________________________Intrinsic viscosity 3.5 (dl/g)Relative viscosity 1.5Molecular weight Park-Johnson method 2,500 Ultracentrifugal method 420,000Sedimentation coefficient 5.3______________________________________
A 10 g of Schizophyllan powder of Example 1 was dispersed in 2 liters of water and the dispersion was heated at 120� C for 20 minutes and then it was stirred to dissolve it by the Warning blender.
The solution was treated by the ultrasonication at the oscillating frequency of 20 KHz in an amplitude of 35 microns and the output of 1 KW at room temperature with stirring.
After the ultrasonication for 30 minutes under confirming the decrease of the viscosity, 10 g of Schizophyllan powder was further added and dispersed in the solution and the dispersion was further treated by the ultrasonication in the same condition.
The operation was repeated for further two times to dissolve 40 g of Schizophyllan in the solution.
After dissolving all of Schizophyllan, the solution was treated by the ultrasonication in the same condition for 6 hours, to obtain 2% of a solution of Neoschizophyllan having the following properties.
The solution had Newtonian flow characteristics as the viscosity characteristic measured by Brookfield viscometer.
According to the tests, the pharmacological activity of the solution of Neoschizophyllan was slightly higher than that of Shizophyllan and the toxicity of the solution of Neoschizophyllan was remarkably lower than that of Schizophyllan.
______________________________________Intrinsic viscosity 5.2 (dl/g)Relative viscosity 310Molecular weight Park-Johnson method 3,800 Ultracentrifugal method 650,000Sedimentation coefficient 6.7______________________________________
A 10 g of Schizophyllan powder of Example 1 was dissolved in 1 liter of water and the solution was treated by the ultrasonification at the room temperature at the oscillating frequency of 30 KHz in an amplitude of 8 microns and the output of 500 W with stirring the solution.
After the ultrasonication for about 4 hours, the solution of Neoschizophyllan having the following properties was obtained.
______________________________________Intrinsic viscosity 2.3 (dl/g)Relative viscosity 80Molecular weight Park-Johnson method 1,800 Ultracentrifugal method 320,000Sedimentation coefficient 3.4______________________________________
A 100 g of Schizophyllan powder of Example 1 was dissolved in 2 liters of water and the solution was treated by the ultrasonication at the room temperature at the oscillating frequency of 8 KHz in an amplitude of 450 microns and the output of 2 KW with stirring the solution.
After the ultrasonication for about 6 hours, the solution of Neoschizophyllan having the following properties was obtained.
______________________________________Intrinsic viscosity 4.2 (dl/g)Relative viscosity 880Molecular weight Park-Johnson method 2,800 Ultracentrifugal method 480,000Sedimentation coefficient 5.5______________________________________
A 20 g of Schizophyllan powder of Example 1 was dissolved in 1 liter of water and the solution was treated by the ultrasonication at the room temperature at the oscillating frequency of 8 KHz in an amplitude of 100 microns and the output of 500 W with stirring the solution.
After the ultrasonication for about 7 hours, the solution of Neoschizophyllan having the following properties was obtained.
______________________________________Intrinsic viscosity 4.8 (dl/g)Relative viscosity 250Molecular weight Park-Johnson method 3,200 Ultracentrifugal method 580,000Sedimentation coefficient 6.2______________________________________
The process of Example 3 was repeated without stirring.
After the ultrasonication for 2 hours, Schizophyllan was adhered at the end of the vibrating plate in dry condition by heating, and the ultrasonication efficiency was remarkably low.
After the ultrasonication, the lowering of the viscosity was found only around the vibrating plate. When the solution was mixed in the stage, the gel having the following properties which was similar to the solution before the ultrasonication was formed.
______________________________________Intrinsic viscosity 9.3 (dl/g)Molecular weight Park-Johnson method 28,000 Ultracentrifugal method 1100,000Sedimentation coefficient 9.3______________________________________
The process of Example 5 was repeated with vigorously stirring under incorporating bubbles.
After the ultrasonication for 7 hours and 13 hours, the solution had the following properties because of bubbles.
______________________________________ after 7 hours after 13 hours______________________________________Intrinsic viscosity 7.8 (dl/g) 4.6 (dl/g)Relative viscosity -- 265Molecular weight Park-Johnson method 11,000 3,400 Ultracentrifugal method 950,000 540,000Sedimentation coefficient 8.5 6.1______________________________________
The antitumor effect of Neoschizophyllan on Sarcoma 180 tumor was compared with that of Schizophyllan.
The test was carried out by the method stated in GANN, 60, p. 137 to 144 (1969).
The solution was given to mice by the intramuscular injection for 10 times once every 2 days 24 hours after the transplantation of tumor. The results are shown in Table 2.
As it is clear from the data of Table 2, Neoschizophyllan had the same effect as that of Schizophyllan.
The optimum dosage of Neoschizophyllan was clearly different from that of Schizophyllan.
Table 2__________________________________________________________________________Dosagemg/kg � times 0.05 � 10 0.1 � 10 0.2 � 10 0.5 � 10 1.0 � 10Number of mice 20 20 20 20 20__________________________________________________________________________Increase of Group of Neo-Body Weight schizophyllan 5.8 3.9 4.6 4.4 3.0 Group of Schi- zophyllan 5.8 3.8 3.1 3.9 3.1 Control 7.9 4.1 7.9 4.4 3.6Tumor inhi- Group of Neo-bition ratio schizophyllan 41.2 71.4 81.5 97.0 97.9 Group of Schi- zophyllan 10.1 62.0 73.1 80.3 89.9No. of mice tum-or disappeared Neoschizophy- llan 2 2 4 11 10 Schizophyllan 0 1 2 4 10__________________________________________________________________________
In accordance with the method of Example 8 of U.S. Pat. No. 3,943,247, the test of the treatment of tuberculosis was carried out with Neoschizophyllan and Schizophyllan.
The effect of Neoschizophyllan was substantially equal to that of Schizophyllan though the optimum dosage was different as shown in Test 1.
|Cited Patent
|Filing date
|Publication date
|Jan 27, 1975
|Jun 14, 1977
|Sumitomo Chemical Company, Limited
|Polymer composition of ethylenic compounds and pullulan
|Journal of Polymer Science, vol. XXV, No. 110 (Aug., 1957) pp. 285-304.
|Citing Patent
|Filing date
|Publication date
|Jan 24, 1983
|Mar 19, 1985
|Kaken Pharmaceutical Co. Ltd.
|Method for a specific depolymerization of a polysaccharide having a rod-like helical conformation
|Jan 12, 1999
|Jun 26, 2001
|Pacific Corporation
|Composition for external application containing a β-1,6-branched-β-1,3-glucan
|Mar 18, 2013
|Jun 26, 2013
|Method for preparing functional polysaccharide and oligosaccharide with low molecular weights by using lyceum-barbarum polysaccharide
|U.S. Classification
|204/157.62, 204/157.68
|International Classification
|Cooperative Classification
|European Classification


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Here's a sample of Toronto councillors' reactions to Wednesday's news that Premier Kathleen Wynne has ordered the Ontario Lottery and Gaming Corp. to apply the same hosting fee formula to Toronto as other cities.
<bullet>Councillor Michael Thompson (Ward 37, Scarborough Centre), right-leaning chair of the economic development committee: "It would appear that the downtown casino proposal is dead if we are not getting the $100 million in guaranteed annual revenue. I want the money for transit and I've been told that a city like Toronto, with the capacity to generate revenues at a casino resort, should expect at least $100 million a year. If the patient was drowning before, the patient is basically in the bottom of the water now and weighted down."
<bullet>Councillor Paul Ainslie (Ward 43, Scarborough East), who also leans right: "Even at $100 million plus revenues, I'd still have concerns about the jobs and our infrastructure, and what are we doing to protect people from health and gambling concerns. At this point for casinos, there's a lot more red flags for me than there are green flags."
- Councillor Norm Kelly (Ward 40, Scarborough-Agincourt), right-leaning: "When you travel, you see national governments, provincial governments, pouring money into their premier cities, reinforcing them, their chances for success in the very competitive international contest between premier cities, and you realize: in Ontario, we're considered to exist on the same plane as Wawa!"
- Councillor Gord Perks (Ward 14, Parkdale-High Park), left-leaning: "I think the casino issue is already dead here at the city. I think all this does is flush out some of the mayor's allies who were planning on voting no anyway."
- Councillor Adam Vaughan (Ward 20, Trinity-Spadina), left-leaning: "The city manager's report with Ernst and Young is wrong; it's not $168 million. The real number is closer to $20 million to $25 million. And that's not enough to destroy every small downtown business, to wipe out the tax base in the downtown core, and to create a traffic gridlock problem the likes of which the city would never survive. I think it kills the casino."
<bullet>Councillor Vincent Crisanti (Ward 1, Etobicoke North), right-leaning: "There has been a lot of focus on the revenue. There are many other benefits aside from the casino. Every indication is that the casino is just a small portion of it. There is the entertainment, there's the convention centre, there's dining … then the benefits of the economic impact, the jobs it's going to create. So there's more than just the revenue in itself."
<bullet>Councillor Glenn De Baeremaeker (Ward 38, Scarborough Centre, left-leaning: "I'm still undecided. I see the merits of both sides, but I haven't seen any real facts in front of me. It's all speculation right now."


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Ronald Killebrew wants to
#BringBackOurGirls: stop the kidnapping of girls in Nigeria
Any attack on one human, is an attack on humanity.
Any attack on one human, is an attack on humanity.
PepsiCo can help stop Conflict Palm Oil plantations from destroying the rainforest homes of the last wild orangutans.
Don't let Congress deny your right to know: Oppose the DARK act
As many as 200 million females are missing because of gendercide. Stand up for girls and women everywhere.
Because we should all support our countrys armed forces as they are the ones putting their lives on the line.
We ask to stop the terrible practice of eating dog meat and tortures to which the dogs are subjected in China.


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youreworthit's Profile
Welcome Friends! So glad you are here!
A little about yours truly - I've been designing shirts since I can remember, I think I made my first t-shirt when I was 8, but don't worry I've come a long way from my puffy paint days!
You're Worth It is my latest venture into the bridal business. I had a shirt for my bachelorette party that said "i'm worth it" and that shirt said it all. YOU are worth it and I can help you show it off! Whether you are announcing an engagement, preparing for your "last single night" on the town or looking for wedding party t-shirts and gifts, I can help! I've so been there and love a custom order, so what are you waiting for? Check out my shop and if you don't see exactly what you are looking for, no worries, I can make it for you! Just convo/email me for details…
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- youreworthit
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Simulate a futuristic game of solo racquetball! Step into a dark corridor, volley a ball off your paddle, and use your reflexes to keep the game alive. This 3D pong challenge will keep getting faster until you miss. It's your serve to win!
P2K8 is one of our selected Arcade Games. Also very popular on this website right now are Cut The Rope 2, Shopping Cart Hero 3, Ducklife 4 and Blockoomz 2015.
Report game as broken
Cancel report of broken game


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Popular Diets
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They are plenty of ways to meet your protein needs, without having to eat meat. The food industry has made leaps and bounds in terms of offering nutritious and delicious vegetarian options for helping you get the protein you need. However, these products are not just for the vegetarian, even you meat lovers can sample these foods and incorporate them into your diet to switch it up and add some spice to your meals!
Soy (soy nuts, edamame, tofu)
Try these:


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Holmen uses cookies to enhance the user experience on the website,
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Holmen's Code of Conduct clarifies and emphasises the requirements and expectations of Holmen's employees. The Code applies to all employees of the Holmen Group and we encourage our business partners to act in line with this code and we take this into account when choosing who we work with.
Holmen supports the ten principles of the UN Global Compact, the eight fundamental conventions of the International Labour Organization (ILO) and OECD's guidelines for multinational companies. The Code of Conduct is based on these principles and provides guidance in day-to-day work, clarifying what each employee can expect of their colleagues regarding Business ethics & handling information, Human rights & labour rights and Environment.
The Code of Conduct is a wide-ranging but not exhaustive document. Holmen's policies and other policy documents provide further guidance on how the different areas are to be handled.
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Drivetime Thursday 21 August 2014
Mary Wilson presents an information packed evening news magazine with all the stories of the day
Drivetime rememberes Albert Reynolds - with Sean Power , Ray McSharry and Fergal Keane
Brian Lally heads for Longford for reaction to the passing of Albert Reynolds
John Cooke reports from James Reilly's family home.
The Taoiseach has once again defended his leadership of Fine Gael.
Presenter: Mary Wilson


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The meteoric increase in the popularity of laparoscopic surgery has resulted in the proliferation of numerous texts on this topic—some are worthwhile; some, essentially worthless. Although some of the earlier texts can be pardoned for presenting little useful information because of the lack of information available at the time, the abundant clinical experience in this field of surgery that now exists causes this excuse to ring hollow for subsequent publications. Greene and Ponsky, in Endoscopic Surgery, have added a well-written and extensive book to the category of worthwhile, useful texts.
This work consists of 43 chapters that deal with a broad range of topics from the history of endoscopic surgery to the use of minimally invasive surgery and endoscopy in pediatric patients. The text is unique in that it addresses the use of a variety of endoscopic techniques, eg, esophagogastroduodenoscopy, colonoscopy, intraluminal ultrasonography, and angioscopy, as well as the
Thank you for submitting a comment on this article. It will be reviewed by JAMA Surgery editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
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Diamond Bar, CA – Builders of SEMA Show vehicles will take center stage in the third annual SEMA Battle of the Builders competition. Introduced in 2014 to recognize and celebrate proven vehicle builders in all market segments, including hot rod, offroad and sport compact, the SEMA Battle of the Builders is considered to be the ultimate builder competition and is open now.
Editor's Note: SEMA recently announced the 2016 recipients for its SEMA Memorial Scholarship and Loan Forgiveness Award Winners. See the list below, along with information regarding how to apply for 2017 awards.
Diamond Bar, CA – Recipients of SEMA scholarships are currently pursuing degrees in Accounting, Automotive Aftermarket, Automotive Technology, Biomedical Engineering, Business Management, Chemical Engineering, Computer & Information Sciences, Electrical Engineering, Graphic Design, Hospitality Industry, Industrial Arts, Industrial Engineering & Design, Marketing, Mechanical Engineering, Multimedia Journalism, Petroleum Engineering and Sports Management.
Diamond Bar, CA – Nominations for the esteemed SEMA industry awards are being accepted now through August 1, 2016 at www.sema.org/awards.
Regarded as the highest, most prestigious honors presented to companies and individuals in the automotive specialty equipment market, the SEMA industry awards are presented for the Person of the Year, Rep Agency of the Year, Warehouse Distributor of the Year, Gen-III Innovator of the Year and Manufacturer of the Year.
Washington, DC – The U.S. Senate passed Senate Resolution 507 (S. Res. 507) designating July 8, 2016 as "Collector Car Appreciation Day." The Resolution was requested by the Specialty Equipment Market Association (SEMA) and its Automotive Restoration Market Organization (ARMO) and Hot Rod Industry Alliance (HRIA) Councils. The date marks the seventh commemoration in what has become an annual event to celebrate and raise awareness of the vital role automotive restoration and collection plays in American society.
S. Res. 507 was sponsored by Congressional Automotive Performance and Motorsports Caucus Co-Chairs Senator Richard Burr (R-NC) and Senator Jon Tester (D-MT). The Senators are strong advocates for the automotive hobby in Washington, D.C. The Caucus is an informal, non-partisan member organization that pays tribute to America's ever growing love affair with the car and motorsports.
DIAMOND BAR, CA – Results of the 2016 SEMA Board of Directors election are in, with Chris Douglas from COMP Performance Group, Kyle Fickler of Aeromotive Inc. and Les Rudd from Bob Cook Sales elected to serve on the board. While Fickler is a current SEMA Board member who was re-elected onto the group, Douglas and Rudd will join as the newest members of the group.
The complete list of 2016–2017 SEMA Board of Directors are:
2016-2017 SEMA Board of Directors
CLACKAMAS, OR – As part of this year's SEMA Show, Warn Industries will be introducing the new PowerPlant. The PowerPlant 9.5 and PowerPlant 12 combine a powerful winch with a high performance air compressor to become the ultimate vehicle-mounted multi tool.
The PowerPlant 9.5 has a pulling capacity of 9,500 lbs., while the PowerPlant 12 will pull 12,000 lbs. Both models are equipped with an air compressor able to fill four 35" tires in eight minutes, and can run air tools as well. With new features such as stainless steel fasteners, a new pressure switch, a revised contactor, a new hose and accessories, and a new flat-black finish, the PowerPlant is better than ever.
Beyond the PowerPlant models, Warn Industries will also have its new line of premium winching accessories and components on display at the SEMA Show. This includes a premium winch hook, shackle, tree trunk protector strap, and snatch block. These items are designed to help you get the most out of your winch, and each features Cerakote™ coating for maximum protection against wear and abrasion.
Every year for the past 49, Tierra Del Sol (TDS) Safari has boasted being one of the biggest Jeep and 4×4 events in Southern California. The off-road gathering takes place at Truckhaven, which is now part of Ocotillo Wells SVRA, with the three-day event offering everything from trail rides, obstacle courses, vendor alleys and more. Next year marks the 50th running of the event, which will take place Friday, March 2, through until Sunday, Mach 4th. Visit www.tds4x4.com for more information.
For full coverage and photo highlights of the 49th Tierra Del Sol, click here.
Photo by Jaime Hernandez
Think you've got the hottest truck, Jeep or off-road vehicle build going? Building a pre-runner or a rock-crawler – what's in your shop? Want a chance to give it the ultimate suspension with Bilstein off-road racing shocks? When you log on to www.ShockMyRide.com you'll get the opportunity to enter Bilstein's new SHOCKMYRIDE contest.
The GRAND PRIZE is a customized Bilstein 9100 Series Suspension Package, plus an all-expenses paid trip to Las Vegas, and two passes for the exclusive 2011 SEMA Show, the Automotive Aftermarket Industry's premiere event that is closed to the public. The trip includes: roundtrip airfare to Las Vegas for 2, and two nights hotel accommodations, plus $300 spending money.
FIRST PRIZE is a set of four 5160 Series Remote Reservoir shocks…and we're giving away five sets!
Entry is easy – just log on, upload your images and videos, along with your story about why we should pick your project! Log back on often to check out your competition.
Contest open now through August 31, 2011. Log on now to enter: http://www.shockmyride.com
Also, log on to www.bilsteinUS.com for complete shock applications.
Bill Caswell decided he needed a break from the adult life. He left his banking job and decided to go racing. In recent years he has tackled rally racing and other forms of car racing, but now he plans to fulfill a dream of competing in the 2010 SCORE Baja 1000. Caswell and crew actually set up shop at Miller Electric's booth at the 2010 SEMA Show building his signature, early-90s BMW into a Baja-capable race vehicle to compete at the 1000.
The plan of attack was a four-day build at SEMA was this:
Day 1 – Main Roll Cage
Day 2 – Front Cage & Suspension
Day 3 – Rear Cage & Suspension
Day 4 – Main Cage, Accessories & Final Review
Truck cap and tonneau cover manufacturer A.R.E. built a unique truck for the 2010 SEMA Show paying tribute to the Pro Football Hall of Fame. With its facilities in Massillon, Ohio, being just 10 or so miles away from the Pro Football HOF in Canton, Ohio, A.R.E. decided to customize a 2011 F-150 tying in all of the intricacies of the HOF into the truck. Before the truck was fully built, A.R.E.'s Director of Marketing Bryan Baker explained the idea of the truck.


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Rolls-Royce rolls out Phantom series II
Mumbai: Rolls-Royce on Friday launched its Phantom Series II -- the latest version of the super luxury car that came out in 2003 -- in the domestic market, priced at Rs 4.64 crore onwards.
"The Indian market continues to prove its appetite for luxury products. There is sustained demand from the country's discerning client base, who appreciate the timeless design of Phantom Series II," Rolls-Royce Motor Cars General Manager for Emerging Markets, Asia, Herfried Hasenoehrl said.
The car comes with fully-LED headlamps as well as a characteristic whiter light, augmenting safety and preventing driver tiredness.
Stating that super luxury car customers were not hit by the slowdown in the economy, Hasenoehrl said there was much higher potential for the segment the Indian market.
"I would say the potential in India exceeds by far than 100 cars," he said, but did not divulge the number of cars Rolls-Royce sold last year.
The company, which at present has three dealerships in Mumbai, Delhi and Hyderabad, will be adding two more outlets shortly, he said.
"All our dealer partners are in discussions to expand the network. We are ready to set up one at Chandigarh shortly and the next in line could be close to Mumbai," Hasenoehrl said.
Without a shot being fired, Pakistan stock markets crash
Reliance Jio impact: Vodafone offers 10 GB data at 1 GB rate
Delhi government bans Chinese firecrackers for this Diwali
7th Pay Commission: Govt employees to get revised allowances from Oct 1; committee to submit report this week
7th Pay Commission: Good news for central government employees as Centre sets up committee to address pay related anomalies
Expert suggestion to investors after the surgical strike of Indian army
Govt announces 3rd list of 27 new smart cities
Rumors spread on the coin of ten rupees in India
RJio may face enjoin on free calls after TRAI start inspecting its tariff plan
Watch: Financial Planning for retired personnel lieu to FD


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Looks like Herb Robert aka Cranesbill (from the shape of the seedheads) - a wild flower, very 'aromatic' foliage when crushed - foliage reddens in dry conditions.
Looks like one of the many types of scale insect https://www.rhs.org.uk/advice/profile?PID=224
Lesley, Wonky is very useful I agree, but it's taken quite a few years of basic groundwork to get her to this useful stage
Maybe some rose cuttings in the offing Verdun?
This is the one I have https://www.moleskine.com/gb/collections/model/product/gardening-journal
It's taken a little time to find out how to make it 'work for me' but now I find it really useful - also it's the perfect size to pop in my handbag to take on garden visits and note 'must haves' and 'maybe's.
Oh dear - and I can understand it
Getting old and a little deaf here Wills ..........
The carbonara I ate in Italy was made with wild mushrooms from the pasture and woodlands - doesn't come much more authentic or classic than that
Don't think they make 'em more reputable than Kelways
Kelways are one of the best. A long established family firm and have won lots of medals including golds at Chelsea. I've not bought from them recently, but I'm sure you'll not have any problems, they have a superb reputation.


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Home > Eyeglasses > Calvin Klein > CK7503 (319)
CK 7503 is available in 5 additional attractive styles
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With no frills and state-of-the-art materials and craftsmanship, these men's glasses stand for stylish design and self-confidence. The rimless frame recedes discreetly into the background, giving it a sophisticated flair. The quadratic shape is a good choice, especially for softer facial features. The square glasses give more contour to a round face. The straight outer edges also give the impression that the face is longer. Whether natural or extravagant - the colour green makes you stand out from the crowd and makes your eyeglasses the perfect accessory.
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Is Priyanka Chopra doing dadagiri on the sets of Mary Kom?
3 years ago
The feisty babe we hear has been calling the shots on the sets of Sanjay Leela Bhansali's ambitious project Priyanka Chopra is fiery, ambitious and self-made B-town star. The 31-year-old has made it big in Bollywood, all on her own just like her 'close buddy' Shahrukh Khan did. The Fashion babe has always made an […]
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Sorry Salman Khan! Fans love Aishwarya Rai's Bulleya from Ae Dil Hai Mushkil more than Sultan's
Hrithik Roshan and Kangana Ranaut's battle is NOT over yet - Rakesh Roshan speaks up!
Listen up Ranbir Kapoor, Salman Khan is #TeamShivaay!
10 Fawad Khan GIFS that totally illustrate our daily emotions!
Did Katrina Kaif DITCH Ranbir Kapoor on Jagga Jasoos sets?
Car sex, making out with strangers - 5 times when Priyanka Chopra went BOLD in Quantico that she has never tried to do in Bollywood!
Ranveer Singh QUASHES all reports of Padmavati being delayed with these pictures!
Lisa Haydon announces her wedding with a HOT KISS - view pic!
Katrina opens up about working with Salman for Tiger Zinda Hai: It's going to be interesting to be back on sets together!
Deepika Padukone, Anushka Sharma and Parineeti Chopra in the running for Hrithik Roshan's Krrish 4?
Ae Dil Hai Mushkil News
Listen up Ranbir Kapoor, Salman Khan is #TeamShivaay!
Will Aishwarya Rai Bachchan promote Ae Dil Hai Mushkil on Salman Khan's Bigg Boss 10?
Salman Khan will not promote Ae Dil Hai Mushkil on Bigg Boss 10 and Aishwarya Rai is not the reason
Katrina Kaif has NOT seen Ranbir Kapoor's Ae Dil Hai Mushkil trailer and here's PROOF!
Sorry Salman Khan! Fans love Aishwarya Rai's Bulleya from Ae Dil Hai Mushkil more than Sultan's
Latest from News
Sushant Singh Rajput feels Priyanka Chopra is a better actress than Deepika Padukone- watch video!
Does Amrita Singh feel Kareena Kapoor Khan has a WRONG influence on daughter Sara Ali Khan?
Yeh Rishta Kya Kehlata Hai 26th September 2016 full episode written update: Akshara dances on Pingaa while Naman fights with Karishma!
Amitabh Bachchan's open letter to Navya was NOT a publicity gimmick - Taapsee Pannu in an EXCLUSIVE interview!
JUST IN! MNS workers protesters station themselves outside Karan Johar's residence -view pic
Daag, Silsila, Lamhe, Kabhie Kabhie – 5 Yash Chopra films that SHOULD get remade!
Harshvardhan Kapoor and Saiyami Kher's Mirzya to be premiered at the London Film Festival on October 6!
Akshay Kumar is not doing Omung Kumar's Five - here's why!
Mirzya trailer review: Second trailer of Harshvardhan Kapoor and Saiyami Kher starrer shows that this film has potential to be an EPIC!
Aamir Khan's 'Shuruaat Hoon Main' video for Global Citizen India is truly inspiring
Never miss any important news!


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If you need a quart of oil (or 12) at Orcas, you can now buy it from your friendly airport manager.
$10/quart for Aeroshell 80W or 100W
$8/quart for Phillips X/C 20W50
Includes tax.
Draft Environmental Assessment for Tree Removal (National Environmental Policy Act-NEPA)
Biplane, the Sequel!
Noise Abatement PLEASE!
- Summer is a busy time and our local residents are outside or have their doors and windows open. Please, please, please, take note of and comply with our noise abatement procedures to the maximum extent possible…
- NoiseAbatementBrochure
Local RV-6 For Sale
- 1999, Built by Helicopter A&P, 2nd owner
- O-320, ~2,000 hrs (Experimental TBO Exempt), 2 New Cylinders, Good Comps, Very Low Oil Burn
- 360-376-3091
Bikes for free use (donations encouraged)
- We have bikes for use free of charge near the fuel pumps. The last 4 of our CTAF will open the lock. Please take the lock with you and use it…and bring the bike and the lock back. If you like these bikes, donations are accepted in the fee boxes or the Port office. We don't have helmets but encourage you to use one.
- If you have a somewhat serviceable old, classicky, cruiser bike (or anything adult-sized really) you might donate, we will take good care of it and keep it dry in the winter…please call
Annotated Nautical Chart of Island Flying References
This was a hasty effort to create a depiction of the geographic references commonly used while flying in the San Juan Islands. I don't currently fly floats and I'm sure other well-qualified pilots will find my emphasis and priorities to be skewed, as well as possibly outright errors, but you can always refer to the source document and do your own study. It does not really seem to render correctly when opened in a browser…recommend downloading and viewing with suitable Adobe Acrobat software (Reader is Free).
San Juans (Annotated) Nautical Chart pdf
Phone-Sized Ferry Schedule
I put this here because I think some visitors to this website might appreciate a "cut-down" version of the ferry schedule that can be read easily on a phone. This is why I started making it in the first place.
The next regular meeting of the Port of Orcas Commission is Thursday, August 7th, 2015 at 4:30 PM in the terminal conference room.
Need Power!!
— We now have a small 12/24V GPU (with both alligator clamps and a NATO plug) for "jump-starting" an airplane. Stop by or call the office when needed. After hours, call the Airport Manager's Cell phone (the number is on my business card which is in a dispenser by the conference room door). Based on the limitations of our insurance, use is at your own risk.
Instrument Procedures — Updates to date!!!
If you find the RNAV-34 is not available in your installed database, would you please let me know? I know of at least one Garmin product where it is flagged as "unavailable" and I'm trying to determine why.
Hangar 28 for Sale
Quality Com-Steel 2,559 Sq.Ft. "T" hangar with: tall electric "Hi-Fold" door,
lighting with 3-way switching, double pedestrian access, Door skylight. Easy
and direct taxiway access to runway and fuel. Common area bathroom &
shower. Plumbing stubbed for bathroom. Separate electric meter with 100 amp
panel. Sealed concrete flooring.
Call for pricing and terms.
Suitable for either multiple aircraft, float plane & boat, single Pilatus, Malibu, or
similar. Lots of storage space and tall enough for mezzanine.
Call: David & Rebekah Selwyn at 360-376-3351
Mel Shapiro at 360-376-5909
Hangar #29 has the left rear corner (12′ x 10'6″) taken by the "T" end of hangar #28. There is a smaller area in the right rear corner dedicated to a sink and toilet.
- BiFold Door… opening: 40′ W x 12'10″ H
- Hangar Depth: 31'6″
- Height to interior Ridge: 30′. (Will accommodate a 2 story apartment space/loft or Airplane stacking lift)
- Concrete Floor in exceptional condition…. no cracking, absolutely flat.
- Lit with multiple high hanging fluorescent lamps
- Toilet and Sink (Shared with adjacent hangar owner – space used in each hangar: 38″ x 72″)
Call or email for additional information:
Mel Shapiro
Tel. 360.376.5909
Cell 360.298.2298
New and Noteworthy:
- A recent visitor's trip report — you can't buy a review like this!
- Unofficial KORS Facebook Page
If you have airport pictures you would be willing to share, please email them to me at email@example.com.


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illustration of an african american barber with arms crossed holding a hair clipper and a pair of scissors with circular barber's pole on isolated white background.
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Sat, 30 September 2006
For Laurie's birthday we go to the other end of Puerto Rico, the west end, to stay at the Tres Sirenas Ocean Front Inn in Rincon. We had a relaxing weekend, every evening we soaked in the jacuzzi while listening to the crash of the surf on the beach. Every morning we had a gourmet breakfast served to us on the porch in front of our room. Harry & Lisa, the owners, told us all about their Bed and Breakfast and the renovations they went through getting it ready and the Caribean decor. Harry took us on a ride all over Rincon to see the other b&b's in the area as well as restaurants, night life and surf spots.
Direct download: No._15_Our_trip_to_Rincon.mp3
Category:podcasts -- posted at: 12:59pm EDT
Chanel Tote Bags Black Dark Leather are not common bags at all.chanel outlet There are already a lot of Metallic Tote from Chanel bags.That's actually fine anyway since the somewhat structured silhouette of this chanel tote bagalone already makes this truly luxurious looking.Well, all the chanel bags are actually luxurious and elegant, but the shade of this particular bag evidently shows it. Like any other Chanel tote bags though, this tote comes just simple and has no other designs aside from the gold and silver-tone logo plaque on the center front.Chanel Bracelets This quilted metallic bronze leather tote features the Chanel logo on one side and a diagonal zipper on the other.Well, all the chanel bags are actually luxurious and elegant, but the shade of this particular bag evidently shows it.
Post your comment:


text:
Hey everybody,
I was recently on Youtube 3 days ago watching videos and everything was fine.I just tried it today and It says my flash player is outdated" or turn off Javascript?
Please click the link to install recent Flash player. Well that doesnt work.
and now it happens on all the sites that have video. Could it be something else?
I own :Wii. 2 wiimotes and 2 nunchucks
Red Steel
Legend of Zelda Twilight Princess
Rayman Raving Rabbids
Rampage: Total Destuction
Madden 07
Super Monkey Ball Banana Blitz
Wario Ware Smooth Moves
That also happened to me once as well. Simply exit the Internet Channel and then select it again. It should be fine now.
The key to immortality is first living a life
worth remembering. - Bruce Lee
PSN ID: Byuakuya


text:
Viscount Systems, Inc. (VSYS) Secures Connecticut School With Freedom 0 commentsMar 14, 2013 10:50 AM | about stocks: VSYS
Viscount Systems, a leading-edge supplier of security systems and software, today announced that its Freedom access control solution has been installed at a private faith-based K-12 school in Connecticut.
"We are pleased to continue making progress in the school security market," stated Stephen Pineau, CEO of Viscount Systems. "Our technology enables schools to more securely control access to their facilities, at a significantly reduced cost versus traditional systems. This enables schools to either reduce the cost of securing each facility or to expand security within the same budget."
"We continue to build new applications to solve the issues facing school security officials and expect to continue building on our successes through 2013," concluded Pineau.
Designing security systems since 1969, Viscount Systems has developed strategic working relationships with leading equipment vendors to support its continued profitability and growth. Viscount has been consistently profitable for nearly 15 years and currently generates annual revenues of approximately $5 million.
For more information on Viscount Systems, visit viscount.com
Please see disclaimer on the QualityStocks website: disclaimer.qualitystocks.netStocks: VSYSBack To QualityStocks' Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Full index of posts »
AirWare Labs Corp. (AIRW) Names New Additions To Executive Management Team $AIRW http://seekingalpha.com/p/1lo7f Feb 20, 2014
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text:
Martha Stewart Shows Us the Correct Way to Exit a Party
(With two full glasses of wine to go.)By Gabriella Paiella
(With two full glasses of wine to go.)By Gabriella Paiella
Stewart had some choice words for the younger generation.By Gabriella Paiella
The lifestyle mogul refused to abide by the no-photo rule at a Hillary Clinton fundraiser.By Gabriella Paiella
We asked the editor-in-chief of Condé Nast Traveler for advice on how to cultivate good taste.By Erica Schwiegershausen
A lesson in apologies.By Maggie Lange
Comments from the idol.By Maggie Lange
It would be "premature."By Maggie Lange
"It takes wonderful aerial photographs."By Maggie Lange
It's a really, really good thing.By Maggie Lange
Just in time for Christmas, in case you did not notice.By Caroline Bankoff
Sometimes self-knowledge comes in pink chiffon.By Maggie Lange
Pillow fight?By Charlotte Cowles
Katie Hatch is leaving her post as editor-in-chief of Martha Stewart Weddings.By Lauren Murrow
"Harp music, cumulus clouds in a bright-blue sky, and happy people sipping cold sake from homemade bamboo cups."By Jessica Pressler


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3 Professional looking GIF banner design project
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3 vehicles matched;
Now showing page 1 of 1. 25 results per page.
Listed by Private Seller
Beautiful and 1955 Mercury M-100 pick-up truck. These were built in Canada between 1946 and 1968 for the Canadian market. The
Listed by MotoeXotica Classic Cars
1949 Mercury M47 Half-ton Custom Pickup Truck Very rare Canadian half-ton pickup - 14,288th unit made that year Originally assembled
Listed by Private Seller
Fully Restored all orignal parts


text:
Lake Powell At Inlet Beach Walton County. Direc...
- 3 Beds
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- 0.85 Acres
Panama City Beach, FL
Lake Powell At Inlet Beach Walton County. Directly Behind The New Restaurants & Boutiques At 30a....
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Panama City Beach, FL
Beautiful, Secluded, Private Lot On Lake Powell, The Largest Coastal Dune Lake In The Region. Bec...
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Hurry This Desirable Lakefront Lot On Gorgeous Lake Powell Will Not Last Long. This Is A 67' X 27...
Panama City Beach, FL
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Lake Powell homes are primarily single family dwellings, several of which are located right on the shores of Powell Lake. There are homes for sale located all throughout this peaceful community. Lake Powell offers residents a place to enjoy the great features of living along a dune lake. In the community residents will find a community center, a pool, tennis courts, a dock and a park. Lake Powell is just a short boat ride away from the Gulf of Mexico as well.
Our team can help your Florida waterfront real estate dreams come true. Call us at 1.850.898.1205 or contact us online for a free consultation.Contact Us!
^ Return to Top of Lake Powell Homes
DISCLAIMER: IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information Source: Bay County Association Of REALTORS® Multiple Listing Service
Listing information last updated on September 30th, 2016 at 6:39am CDT.
The Beaches 360
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455 Harrison Avenue
Suite C
Panama City, FL 32401
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text:
OSCARS: Cameron Diaz To Present
Beverly Hills, CA – Cameron Diaz will present at the 84th Academy Awards ceremony, telecast producers Brian Grazer and Don Mischer announced today. Diaz will be seen next in "What to Expect When You're Expecting" and "Gambit."
[PHOTOS] Oscar Nominees Part 2: Lady Gaga, Cate Blanchett, Brie Larson, Kate Winslet, Charlotte Rampling, Saoirse Ronan & More
Between Cameron, Halle, and JLo – plus a musical performance by Smash Mouth, this'll be the best telecast yet!
Wait! What? Hollywood's arrested development?
Here's hoping they do a Something About Mary parody.
Comments are closed.


text:
I anticipate that this book will lead many more faculty members to see their teaching as an opportunity to engage in SOTL. And, even though it is clearly an effective guide for individual thinking, it will be even more effective when used as the focus of a Faculty Learning Community or by a less formal group of faculty working together. Indeed, the core structure and especially the worksheets will help groups to stay focused and productive. However used, it will help teachers use SOTL as a way to improve their students' learning and to foster more advanced learning outcomes while simultaneously enhancing the faculty members' own professional development and careers. I hope you find it as interesting and helpful as I did."
"Cathy Bishop-Clark and Beth Dietz-Uhler bring to this volume their own contagious passion for the scholarship of teaching and learning—but also an ability to translate their journey into steps that those newer to the work can easily follow. The result is both practical and inspiring."


text:
The Year's Best
The Year's Best
Nothing makes you stop and wonder more than when you come to realize that a year has passed in your life and you aren't sure
just where it went.
Well, you know you lived it because you're here to tell about it, but what difference did it make?
You could say, "Well, I'm a year older."
In some cases you might say, "I'm a year wiser."
But are you any different?
Do you feel different?
Do you think differently?
Do you look different?
Do you act differently than you did a year ago?
What difference has a year made in your life?
If you haven't yet done so, now might be a good time to reflect on the past year.
Jot down a few highlights.
Don't forget the small things that might perhaps be insignificant to someone else,
but that mean something to you.
Take an inventory of all those things that have happened, places you've been,
people you've met, and changes you've made.
Think about the ripple effect. Who else in your life was impacted by the same things that touched you?
If there isn't anything that jumps out at you, I would offer a suggestion.
Take a closer look at the tapestry of your life in the last year.
Even if you have to get out the magnifying glass and inspect the lint of that tapestry.
There are so many little bits and pieces of life that make it good and wonderful and
awe~inspiring. Pick each of them. Collect them all in one place in your heart.
Now you have them to hold onto. The year's best. The best of you. The best of a year in your life.
A soft place to lay your head at night and a warm comfort to cradle your dreams of tomorrow.
Dream anew. Dream big. You have everything you need to propel you into a wonder~full New Year ahead.