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Senate Antagonist Cruz Makes Nice With Campaign FundraisersLongtime Senate troublemaker Ted Cruz is trying to make nice with some of his establishment colleagues, with peace offerings where it counts most: their campaign war chests.
Cruz Stands Firm, Defends Decision Not To Endorse TrumpTexas Senator Ted Cruz is defiant in his decision not to endorse Republican presidential candidate Donald Trump. A CBS 11 News crew is in Cleveland and spent part of the morning with Texas delegates who are deeply divided.
Thunderous Boos For Ted Cruz After He Refuses Trump EndorsementTexas Senator Ted Cruz tried to link arms with Republicans at the party's national convention but was booed lustily by delegates when he ended his speech without offering Donald Trump his endorsement.
No Endorsement For Trump From CruzDelegates on the floor implored Cruz to back the nominee, chanting Trump's name, then erupting in a chorus of boos when he ignored their pleas.
Quiet Cruz Weighs Role In Trump Convention RevoltSen. Ted Cruz is refusing to condemn a rebellion against Donald Trump at the Republican National Convention as the fiery Texas conservative weighs his political future against the prospect of a national Republican embarrassment.
Cruz Shuns Trump, GOP Unity; Says 'Challenges' May Lie AheadTed Cruz used his first speech since dropping out of the presidential race not to endorse Donald Trump or call for Republican unity behind him.
Cruz Running For Re-election As U.S. Senator From Texas"I will continue fighting for jobs, freedom, and security in the Senate for 27 million Texans and all Americans," says Cruz.
Texas Republicans Lose Cruz, Gain Trump - But Do They Want Him?Texas Republicans headed to next week's state convention are finding themselves without their expected candidate, as the Lone Star State's primary winner, Senator Ted Cruz, suspends his campaign.
Cruz Drops Out Of Race For PresidentTed Cruz suspended his campaign for president, putting Donald Trump on a glide path to claim the Republican Party's nomination.
Trump Virtually Clinches GOP NominationDonald Trump took a major step toward sewing up the Republican presidential nomination Tuesday with a victory in Indiana's primary election.
Cruz Fights For Survival Trump Eyes Indiana KnockoutTed Cruz's conservative crusade for the presidency fought for new life Monday ahead of an Indiana vote that could effectively end the GOP's primary season.
Trump Backers Cry Foul Over Loss At Arizona GOP ConventionTexas Sen. Ted Cruz pulled out a strategic victory at Saturday's Arizona Republican Party convention, nailing down a large majority of delegates to the national convention amid cheating accusations from backers of businessman Donald Trump.


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* S&P has peaked and sever sell off may send BEAT under $5
* CEO and other officers have not bought shares even at these low levels even after the Q2 report when they can buy (see Yahoo financial)
* The clinical report that is so advertised by BEAT, was prepared by a doctor that was working for Cardionet. (see link 1)
* Cardionet has 6 competitors and 2 of them has has exact product like MCOT
* The Cardiologists are not really happy with MCOT and also with Lifewatch's product (see link 2)
* BEAT is burning 18M cash every 6 months. It may consider selling shares to raise cash. ( Listen to the CC of Q2)
* Not every bad news is discounted in the stock and more bad news( more rate cuts, more class actions, more competitions, more downgrades, selling shares) will push the stock down.
* Revenues were growing fast since 2006, but reimbursement rate cuts now made BEAT a negative growth company (see Yahoo financial)
* BEAT has large institutional holding, but part of them selling because they dont trust the CEO & Cardionet products anymore.( listen to the attacks of analysts in the last CC)
first good post I saw on this board, thanks.
It's back under 8 now, where it belongs for today.
hey roger.....no offense but just just go away, theres just not enough room for that big of a dick on this board
Hedge funds know about the bad news coming and jumped the the pps today to sell shares. I am sure about failure of negotiation between Highmark and BEAT.
Beware of hedge fund manipulation!
BEAT it Beat it..... lol
17 August 2009
For the first time in months, the foundation of the 50% rally is being called into question. There is no doubt that the March bottom in the stock market was largely driven by government intervention. What the government was relying on with this plan, however, was that they could buy enough time to get the consumer back on their feet. Recent data, however, is beginning to show signs that the consumer is just as weak as they've ever been and showing little to no signs of recovery.
As we've been quick to point out, the real underlying components of this recovery have been questionable at best. Rail data continues to come in incredibly weak, retail sales have shown almost no signs of recovery and corporate earnings have shown no signs of organic growth (i.e., the no revenue recovery). Governments around the world are running short on time as global stimulus plans begin to lose their gusto heading into Q3 & Q4 of 2009.
The most alarming government intervention has not been in the U.S., however. China, one of the primary drivers of the global recovery, could be building a recovery on quicksand. Deloitte is out with a recent report detailing this intervention and the potential unsustainability of the government induced recovery:
Though the economy is forecast to grow above 8 percent in 2009 — it is likely to happen — there are significant vulnerabilities in the system. Much of the growth is being driven by the state and very little by consumers. For any sustained recovery, and because external markets still remain weak, domestic consumers must eventually become center stage in the recovery process, something yet to happen. Though car sales are up significantly, the high number is because of the base effect as well as government subsidies — it means car sales will falter sooner or later. Large swathes of migrant workers lost their jobs (they don't show up in official unemployment statistics) and haven't found new ones; the retail sector is at risk once subsidies on appliances are withdrawn.
As I type, Asian stock markets are all down 3%+. U.S. stock futures are down 1%. The so called "recovery" has been powerful thus far, but will almost certainly sink beneath the sand if the consumer does not find their footing. Thus far, there are little to no signs of this occurring.
S&P selloff is possible, however the rest of your reasons aren't incredibly compelling and your links don't work.
BEAT is a spec play at this point. Rates renegotiated = $$$. Rates remain locked = -$$$. It's a 50/50 shot, however several companies' independent survival obviously depend on it, so I would imagine they are lobbying pretty hard to renegotiate the reimbursement.
If Sept 1 rolls around without any news, I would imagine the stock wouldn't be doing much different than it is now. The new rate is reflected in the current price. Also, should rates remain stuck, management is going to be looking to sell the company per the CC - which means a fair bump in share price when the deal is announced.
Bottom line is that at 7, the stock is at fire sale prices, and I don't see any reason why someone should unload their longs at this point. Thanks for a rational post BTW.
Yahoo does let to provide the link for the third reason. Goole " Cardionet vs. Life watch" and you will see how cardiologists are complaining about cardionet
From that link:
<<CardioNet is no better and has nothing more to offer. Most cardiologists bitch about their CardioNet experience from poor sales reps, lack of customer service and reimbursement issues. Patients get stuck with hefty bills. Let's face it the patient experience dictates everything.>>
Nice try. LOL
Ask yourself why CEO and other officers have not bought shares even at these low levels after 60% sell off.
Anybody smart can answer this simple question?

subset: commoncrawl


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Street wawa.
Eye on the guy with the hula hoop. I filmed this. Not a repost. Awesome sound!!!!
By: Yrrom | Comments: 33 | Views: 2175 | Votes: 1 | Shared: 0
Location: Santa Monica, California, United States | Leaked: Aug-28-2016 in Other Entertainment
Girl Does Hula Hoop Tricks While Surfing
As this girl surfed on a wave like a boss, she grabbed a hula hoop and did some tricks with it. He maintained her balance on her board as she weaved herself in and out of the hoop.
By: DailyPicksandFlicks | Comments: 102 | Views: 5879 | Votes: 9 | Shared: 0
Leaked: Aug-9-2016 in Other Entertainment
The hula hooping Hindu sings on top of bed.
Please someone explain why this is on Breaking news
By: white rhino | Comments: 17 | Views: 855 | Votes: 0 | Shared: 0
Leaked: Aug-19-2016 in Other Entertainment
Ladyboy Gives Hula Hoop Demo
Yeah I bet some of you would still tap this too.
By: mrgod2u | Comments: 154 | Views: 4770 | Votes: 13 | Shared: 0
Location: Thailand | Leaked: Jul-14-2016 in Other Entertainment
Man Uses Giant Tire as Hula Hoop
This guy's hips were one with a 120 pound tractor trailer tire as he hula hooped with it. He shook his body like a salsa dancer and made swinging a heavy object around his body look easy.
By: DailyPicksandFlicks | Comments: 304 | Views: 64047 | Votes: 92 | Shared: 379
Leaked: Apr-21-2016 in Other Entertainment
Aggressive Girl Plays with Hula Hoop
This girl was being aggressive while she played with her hula hoop. She was so aggro, she broke the toy in half and looked disappointed when she did the deed.
By: DailyPicksandFlicks | Comments: 56 | Views: 5931 | Votes: 2 | Shared: 0
Leaked: Dec-4-2015 in Other Entertainment
Hula Hoop Russian style!! 2015
Hula Hoop Russian style!! 2015
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Location: Russia | Leaked: Jul-19-2015 in Other Entertainment
Michelle Obama Hula Hoop at Whitehouse
Michelle Obama Hula Hoop video on Whitehouse lawn with school children for healthy kids fair.
By: josh_97501 | Comments: 217 | Views: 53134 | Votes: 5 | Shared: 0
Leaked: Oct-22-2009 in News
Hula Hoop World Record
Hula Hoop
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Leaked: Apr-11-2009 in Arts and Entertainment
Hula Hoop Headstand Fail
While trying to learn how to do a foot hooping headstand, this girl lost her balance and slammed her face right into the concrete. Luckily, she was just fine and was able to laugh it off with her frie
By: DailyPicksandFlicks | Comments: 6 | Views: 1216 | Votes: 0 | Shared: 0
Leaked: Mar-14-2016 in Other Entertainment
Neon Hula Hoop Honey
Katie Sunshine (other hot hula chick) looks like she has got some competition ..... this dancer wears less, so she gets my vote. Katie, when can we expect a better offer ?
By: Aussie | Comments: 83 | Views: 7566 | Votes: 10 | Shared: 62
Leaked: Oct-12-2012 in Sexy
Hot Hula Hoop Chick Wearing Iron Man Leggings
As described
By: meister2 | Comments: 81 | Views: 5263 | Votes: 12 | Shared: 0
Leaked: Oct-8-2015 in Other Entertainment
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Blitz for Charity
Doomsday is upon us, and Half Price Books is hosting the much-anticipated event. Well, not exactly. Artist and former Dallas Cowboys Doomsday Defense member Dave Edwards will be on hand from 10 a.m. to noon Friday at the 5803 E. Northwest Highway location, with 50 limited-edition reproductions of his original artwork, "Doomsday." All 50 copies have been individually autographed by former Cowboys defensemen Edwards, Bob Lilly, George Andrie, Mel Refro, Lee Roy Jordan, Jethro Pugh and Larry Cole. The prints will sell for $100 each. Proceeds benefit Literacy Instruction for Texas. Call 214-379-8000.
Fri., Dec. 15, 10 a.m.-noon
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Collection The Library of Congress Celebrates the Songs of America
Results: 1-1 of 1 | Refined by: Part of: The Library of Congress Celebrates the Songs of America Remove Language: Latin Remove Subject: Sacred Songs (high Voice) With Organ Remove Contributor: Agustin J. Morales Remove
Notated Music
Christmas vesper hymn
Sheet Music. print | 1 score | From: Music Copyright Deposits, 1820-1860 (Microfilm M 3106) Also available through the Library of Congress Web Site as facsimile page images. (Additional Physical Form). In bound volumes: Copyright Deposits 1820-1860 Print (Form). Electronic Resource (Form). Remote (Form).
- Contributor: Agustin J. Morales - Morales, Agustin J. - Hughes
- Date: 1841
Look inside: 8 results


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Darice Adhesive Paper Butterfly Tags 0.5" White
Product Actions
BUY ONLINE PICK-UP IN-STORE now available in a store near you.
Pick-up in one of our locations near you.
Additional Information
Organize your jewelry by labeling them with the Darice Adhesive Paper Butterfly Tags 0.5''. Great for adding details like weight, metal composition, color or size, these tags are easy to use and durable. They are designed to fit into the jewelry by occupying minimal space. You can use these butterfly labels to segregate rings, necklaces, bracelets or bangles according to their style, metal composition or collection. This package includes 112 adhesive butterfly tags.
- Brand: Darice
- Includes 112 adhesive butterfly tags
- Dimensions: 1.38 x 0.5 inches
- Handling Code:
Items shipping from our warehouse ship within 3 business days (Mon-Fri) for standard shipping. If an order is placed on Friday, Saturday or Sunday, it will ship out within 3 business days the following week. Items shipping direct from the manufacturer will take additional processing time and ship separate from the remainder of your order. See our Full Shipping Policy >
|In-Home Arrival Estimate
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|Express Plus
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For pricing information, please see our shipping table, shipping prices are based on order total.
If you aren't 100% satisfied with your order, you can return it to us for a refund within 90 days of delivery. To make returning an item easy, we offer a return shipping label with most shipping packages or you may ship the package back on your own. If you use our shipping label, you will receive a refund back to your original payment method, minus a $5 shipping fee. See Full Return Policy >
Personalized products can not be returned. Every order is custom printed for the person who ordered it and therefore can not be resold. If you received product that was flawed or damaged, we will be happy to work with you on a case by case basis. Please call 888.739.4120, Mon.-Sat. 9am-7pm EST, to determine return eligibility & process.


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BelliView All Brands
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Be "in-the-know" when we add new styles of Belli to our website! Simply sign up and we'll notify you.
Zappos.com respects your privacy. We don't rent or sell your personal information to anyone.
About Belli
For expecting moms, Belli is Picky for a Purpose. Belli provides soothing, balanced skincare products that pamper and protect. Their collections – Belli Pregnancy, Belli Motherhood and Belli Baby – consider the specific skincare needs of each stage of pregnancy, with thoughtful attention to providing peace of mind. Every product is allergy tested, and free of artificial dyes, phthalates and paraben preservatives.
Belli does their homework when it comes to skincare ingredients so women can embrace life and enhance beauty. The ingredient selections in their skincare formulations are based upon an extensive review of published medical studies. The searches include four databases: TERIS, TOXLINE, DART, and MEDLINE - that comprise over 16 million published medical studies in over 5,000 international journals. Belli also LactMed screens all ingredients in the Belli Pregnancy collection so women can continue to use the products postpartum while nursing. *LactMed is a peer-reviewed and fully referenced database of drugs to which breastfeeding mothers may be exposed.
At Belli, their love of pregnancy and motherhood guides everything they do. Their goal is to support and encourage new mothers, inspiring self-confidence and well-being. It is no surprise that Belli is the skincare brand most recommended by OB/GYNs.


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According to our records, Val Jansante is possibly single.
Val Jansante is a 95 year old American Football (American) Player born on 27th September, 1920 in LaBelle, PA. His zodiac sign is Libra
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|19 Reviews
|Half Baths
|Property type
|chateau / country house
|Minimum Stay
|6 nights
When you book through the HomeAway checkout, your booking is backed by our Book with Confidence Guarantee™ offering comprehensive payment protection.Learn more
Nestled in the hills beyond the Silverado Golf Resort and Spa, the Wine Getaway is a secluded Napa Valley very spacious 3,200 sq. ft. vacation home. It is located fifteen to twenty minutes from the Silverado Trail, and wine-country activities. The home is set amid 22 acres, with two small lakes and 5 acres of Cabernet Sauvignon vines. There are 4 bedrooms, 3 King and 1 Queen. The Queen bed is located in a guest house adjacent to the main house.
Enjoy ping pong, bocce ball, walks in the vineyard, a picnic next to the lakes, fishing, and the splendid views. There is an eight person MAXIMUM.
For a one week stay, receive ONE NIGHT FREE. Owner will help you with that special price.
We have lowered our pricing to compensate for any VRBO fees to the guest.
This property appealed to us with the lakes and delightful birds and wildlife, as well as several vistas of the Cabernet vineyards on this large 22 acre property.
You will find this a peaceful retreat away from it all. Some of the residents include the egret, blue heron, geese, turkeys, quail, muskrat, an otter, and various breeds of ducks, depending on the season.
There are bass in the lakes as well, so some fishing catch and release is allowed.
Enjoy taking time to visit wineries, a few of the closest being in the Napa area, Yountville and Oakville. Ask us for suggestions to local wineries and restaurants.
First of all, thank you very much for the bottle of Dos Lagos. We took it with us to dinner one night and everyone in our group rated it at the top of the wines we tasted while in Napa (and we tasted a lot of wine!).
Our stay at your home was delightful, and it accommodated our needs perfectly. Although we did not make use of the outdoor grills, and barely used the kitchen (we dined out for all meals except a light breakfast each morning), we made full use of all the other amenities. We swam, we played bocce ball, we went on hikes, and we soaked up the sun on your deck. Everything worked that was supposed to work and the atmosphere at your home is warm and welcoming.
Thank you for helping to make our Napa vacation a fantastic, memorable experience.
Marcie and Tom,
I want to express my sincere thanks for welcoming us all into your beautiful home. All 8 of us remarked daily how lucky we were to have found your home for our wine country getaway. The bedrooms accommodated us all beautifully. The kitchen provided us all the necessities to prepare gourmet meals for all 8 of us, and the pool provided us with a refreshing recharge in the middle of the day after the beautiful Napa weather allowed us a gorgeous day of touring! Hiking to the top of Atlas Peak Road gave us a great wake-up to our days, and the peaceful seclusion of your vineyards provided us all the rest and relaxation we sought. The ping pong table offered us an outlet for our competitive sides, as did the bocce court!
Our dinner at Bistro Don Giovanni was a special event to cap off our time in Napa. The food was well-prepared, the wine list was well thought out, the desserts were sublime and the ambience was energetic. If there weren't so many great choices in the Valley, I'd say we would surely return, but knowing myself, I'd probably want to partake of another of your recommendations (say, il Posto?) and the Valley's many outstanding offerings.
As for our stay in your home, I'd return there in a heartbeat! Thanks again. Feel welcomed if you are ever in Sheboygan!
Dos Lagos Vineyard and home is the best stay to truly understand the Wine Country story!
The ride on Atlas Peak Road ( from Silverado CC) is relaxing, eventful and enjoyable. It's a plus!
The home was in most satisfactory condition:
• Beds were well made, totally comfortable,
• Bathrooms, clean, neat + soap, tp, etc all convenient and sufficient
• Kitchen: Milk, butter, water, olive oil, coffee were all pluses.
• Pool & outside areas: Clean, neat, and superb morning swim
• Vineyards: A joy to walk through. Wild blackberries were "stolen" and added to morning cereal. Yummy!
• Golf: Silverado: Always enjoyable. The Napa Public Kennedy Course (just shy of town) at $45 is a winner for it is a challenging course, adequately maintained golf course set up among lakes and streams in lower Napa.
• Food: We took advantage of Silverado's Brut & Bird Thursday night special for two @ $45: It was superb. Marvelous citrus salad, succulent broasted chicken, freshly mashed potatoes and gravy, coleslaw & kale veggie plus a split of Domaine Chandon each.
o Genova Delicatessen: So good to find still operating! Sandwiches & salads are superbly prepared. Same old style people behind the counter as 30 years ago in Oakland & SF
o Ristorante Allegria: Excellent pappardelle con fungi! My linguini con vongole e marinara was quite good. Would go again.
o Bodega Bay Oysters: On Valley Ford Rd, was enjoyable. Good selection & so fresh. We picnicked under the trees on their tree filled grounds.
o Occidental's Neri Restaurant is still going strong: Home baked pastries, bread galore and their ravioli's have always been so good with chard, meats and a dough that floats to the heavens.
o Tasca Tasca: Sonoma's Portuguese tapa style bar restaurant was enjoyable with a good selection of old world wine and beer plus Azorean specialties. Manuel Azevedo (La Sallette) owns this new restaurant also.
o Pat's Runway: It's not Jonesy's menu, but they still do have Jonesy's potatoes.
• Aside from the delicious Dos Lagos Cab (a bottle provided), Luna's was enjoyable with a Sunday guitar jazz player.
• Chimney Rock was over the top with Tom Price being our server and guide into the vineyard and grounds.
• Hess & art exhibits: Interesting. Passed on Stag's Leap @ $65 pp tasting!
The property was the perfect rental. It had a pool, 2 lakes on a vineyard. The Host Marcie and her Husband Tom were the absolute perfect Host. They are beautiful people with a beautiful property.
The property was just so beautiful-with views of two lakes and easy access to all of the vineyards for walking.
We fished at the second lake, and had a glass of the owners amazing wine while watching turtles swim about. The pool at the house was great, and lots of space to sit with umbrellas and comfortable seating.
The owner was very responsive both by email and by phone, and offered us help and information prior to our trip.
The kitchen has everything you can want, so a chef can easily cook in the kitchen or with the outdoor gas barbecue.
We will definitely come back!
I know I speak for our entire group when I say that this property is truly one of the most beautiful
properties we have stayed at. The large home is very spacious and comfortable. The beds are super comfy
and the linens are great quality. Sitting on the patio by the pool with a glass of the owners special and amazing Cabernet was so relaxing. We loved taking walks in the vineyards by the lakes, and even had a picnic.
We did barbecues often, while sitting at the upper deck, and gazing out at the lovely lake and mountain views.
We spent time in Napa valley at various wineries, and dined out at some of the great restaurants Napa has to offer.
Our trip to Napa was made even better by having this oasis to come home to each evening. In fact, the property is so beautiful and relaxing we did not even want to venture out to see the fabulous other Napa sites on our list. The kitchen is a chef's dream, fully stocked with a great 6 burner gas range, convection oven, and stainless appliances throughout. A brand new Weber grill was used extensively!! The Lakes are teeming with Bass, and the owners provided fishing gear, although we did augment it with a trip to the store to replenish the lures we lost! We took daily walks up and down the hill and saw tons of wildlife (deer, turkey, geese, ducks, etc.). An added bonus was the presence of a ping pong table in the huge family room - needless to say hours were spent doing heated ping-pong battles amongst our group. The Wine was simply outstanding, the best we had on our trip to the many wineries in Napa. Maybe it was better since we could commune with the vines that produced the fruit? Probably the world class winemaker did not hurt. This is a truly one of a kind immersion into what makes Napa great - don't miss the chance to stay here! We will be back!
Almost official size Bocce Ball Court below the house...
There is now a picnic table and large umbrella down by the second lake.
|Rate Period
|Weekend Night
My Standard Rate
6 night minimum stay
|cleaning fee
|Refundable damage deposit
|Tax Rate
blank rental agreement shown when you start your instant pay. For a one week stay, you receive one night free!


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Rent Ta Hsueh and Chung Yung 1st edition today, or search our site for other textbooks by Xinzhong Yao. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Penguin Classics.
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Our luxury restroom trailers are an elegant way to meet the needs of your guests or customers. Th... Read More
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text:
Microsoft Promotes Margo Day, U.S. Partner Chief
Microsoft has promoted Margo Day to vice president for U.S. Partners. Day had been general manager of that group.
Microsoft has promoted Margo Day to vice president for U.S. Partners. Day had been general manager of that group.
Good Technology launched its wireless e-mail service and handheld device a year ago and has gotten such rave reviews, according to Good officials, it already has more than 750 companies as customers.
Integration is the word as Computer Associates International looks to tighten the bonds between multiple storage management technologies.
Internet Security Systems this week plans to unveil an upgrade to its Dynamic Threat Protection platform, including new versions of its Internet Scanner vulnerability assessment tool and RealSecure Server and RealSecure Desktop intrusion-prevention products.
Hewlett-Packard plans to offer distributors more incentives to sell products through an enhanced HP Integrated Partner program.
3Com this week is boosting its efforts in the security space with the launch of its Security Advantage channel program.
The Anti-Spam Research Group is working on a plan to end spam.
In the escalating controversy that pits The SCO Group--owner of one of the original Unix operating systems--against Linux developers and distributors, Microsoft has come down, predictably, on the side of SCO. Yet, overlooked in the stir created when Microsoft recently licensed SCO's Unix for use in some of its products is the fact that Microsoft itself has been easing restrictions on its own code.
Microsoft chief executive Steve Ballmer sold 39.3 million shares of Microsoft stock worth about $1 billion in order to diversify his financial investments, the company said Friday.
The Bush administration plans to appoint a new cybersecurity chief for the government inside the Homeland Security Department, replacing a position once held by a special adviser to the president. Industry leaders worry the new post won't be powerful enough.
Microsoft Business Solutions hopes to deliver on its promised unified code base for business applications by late next year, sources said.
BMC Software's Remedy unit next week plans to unveil the latest version of its IT Service Management suite.
The SCO Group last week enlisted Microsoft's help to bolster its Unix intellectual property battle against IBM,a move that drew more cries from Linux advocates and even solution providers.
Wincor Nixdorf and Pinnacle executives hope the successful deployment of a POS system at Red Apple Markets signals the beginning of a mutually profitable partnership.
Sun Microsystems further defined its low-cost computing strategy last week with a trio of expected moves: It reaffirmed its relationship with Oracle, introduced low-cost x86 servers and proclaimed Red Hat its official Linux distribution.
5 Companies That Had A Rough Week
For the week ending Sept. 30, CRN looks at IT companies that were unfortunate, unsuccessful or just didn't make good decisions.
5 Companies That Came To Win This Week
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Q&A: Avast CEO On AVG Acquisition And Why Large Endpoint Security Companies Aren't 'Dinosaurs'
Avast CEO Vince Steckler sat down with CRN to talk about the closing of the company's acquisition of AVG and what partners can expect from the combined companies.
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Operation Ward 57
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It's no secret that the SEC and it's fan base is obsessed with football. And why not? Everyone loves winners and one thing SEC football does, is win and win big. SEC Basketball on the other hand isn't quite as dominant. Despite having on of the most successful programs ever in Kentucky and another program which has been really good winning back to back titles and winning a lot of tournament games over the past 20 years in Florida. Let's not also forget the consistency and competitiveness of Vanderbilt. Unlike in football, the high tide (no pun intended) hasn't raised all ships.
Right now it looks that only four teams are likely to make the big dance; Kentucky, Texas A&M, Vanderbilt and South Carolina. With the Gamecocks really on the edge of the tournament, it's possible we could see only three SEC teams in the tournament. Notice LSU, wasn't mentioned. Unless they win the SEC Tournament, the Tigers will play in the NIT. The other aspect of the Tournament is seeding and it isn't looking great right now for the SEC. It looks like both Kentucky and Texas A&M may only be as high as 4 seeds.
Now let's compare this to other leagues. The ACC is probably going to get 7 teams in and maybe 8, and it would be 9 if Louisville didn't self impose a ban. Within the ACC, you have three teams vying for a 1 seed in UNC, UVA and Miami. All three are probably locks for at least a 1 or a 2 seed. The Pac-12 is looking at 7 teams in though no #1 seeds right now. The Big Ten is looking at 7 teams as is the Big 12, with Kansas perhaps the only team locked in as a 1 seed. Even the Big East will get more teams in than the SEC, and they have two teams vying for 1 seeds in Villanova and Xavier.
Before I start getting hate mail for bashing the conference, let me be clear, the tournament is as wide open as it ever has been. Kentucky has probably the best back court in the country with Tyler Ulis and Jamal Murray. They could very well make a deep run and we know Coach Cal has done it before. Texas A&M is another team with a make up to make a nice run. They are well disciplined on both ends of the court. They have some size, play physical, and smart. Ditto with Vanderbilt. It's very possible that three SEC teams make it to the second weekend. So sure the conference lacks depth and consistency with the teams up and down the standings, however the teams that will make it, have the make up to make a run. And that's what makes the NCAA Tournament the best sporting event in the country.
Welcome to March! Let the madness begin!


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The Autobiography Of Sonny BargerNarrated by the visionary founding member, Hell's Angel provides a fascinating all-access pass to the secret world of the notorious Hell's Angels Motorcycle Club. Sonny Barger recounts the birth of the original Oakland Hell's Angels and the four turbulent decades that followed. Hell's Angel also chronicles the way the HAMC revolutionized the look of the Harley-Davidson motorcycle and built what
$7.99Ralph "Sonny" Barger first gained the attention of the book world with his bestselling memoir Hell's Angel. Now he uses what he's learned from a life insidea subculture few will ever know to create his no-holds-barred first novel, giving readers a taste of thecamaraderie, the pain, and the thrills of what it's like to live life on two wheels.Everett John "Patch" Kinkade just wants to be left alone
Sonny Barger's Guide to Motorcycling"The baddest man on two wheels."—Rolling Stone One of the founders and the most famous member of the infamous Hell's Angels Motorcycle Club, Ralph "Sonny" Barger says, "Let's Ride" with this ultimate guide to motorcycling. With expert co-author Darwin Holmstrom—former writer for Motorcyclist magazine and author of The Complete Idiot's Guide to Motorcycles—Barger, "The archangel of all Hells Angels
Hell-Raising Motorcycle StoriesAn angel spreads his wings. . . . Sonny Barger is the number-one spokesman for the motorcycle experience. His New York Times bestseller, Hell's Angel, was an exhilarating history of his adventures with the world's most notorious motorcycle club. Now he brings us rousing, moving, and wildly entertaining true stories of his renegade brothers and sisters in the relentless pursuit of liberty,
$7.49There are few men who are as quintessentially American as Sonny Barger. He is patriotic—a veteran who loves his country. He is independent—choosing his own path on his motorcycle, living life on his own terms. He is outspoken—he has boldly criticized injustices in American law and society despite the backlash this has evoked from the establishment. Yet the element that he finds most important,
Stargate SG1-04: City of the GodsWhen a Crystal Skull is discovered beneath the pyramid of the Sun in Mexico, it ignites a cataclysmic chain of events that maroons SG-1 on a dying world. Xalótcan is a brutal society, steeped in death and sacrifice, where the bloody gods of the Aztecs demand tribute from a fearful and superstitious population. But that's the least of Colonel Jack O'Neill's problems.
Enhancing the Art & Science of Teaching With TechnologySuccessfully leverage technology to enhance classroom practices with this practical resource. The authors demonstrate the importance of educational technology, which is quickly becoming an essential component in effective teaching. Included are over 100 organized classroom strategies, vignettes that show each section's strategies in action, and a glossary of classroom-relevant technology terms.
$1.99Scarlett Summers has made it back to the past, but nothing is the same. It's almost impossible to blend in when she knows almost nothing about the people surrounding her—including herself. Dante is alive, but there is one major thing that sets him apart from the Dante she knew: he hates her. Grace is nowhere to be found, and eventually Scarlett convinces Dante to help her look for her. At first
Sonny Liston Was a Friend of MineThe author's world encompasses dilapidated fight arenas, state mental hospitals & chaotic emergency rooms. The inhabitants are his brilliantly etched characters, who battle desperately against fate in a game of life they cannot win but dare not lose. As we approach the end of the century & the millennium, no one writes better or more vividly than Jones does about the personal, private apocalypses
$9.99In the comics boom of the 1940s, a legend was born: the Green Turtle. He solved crimes and fought injustice just like the other comics characters. But this mysterious masked crusader was hiding something more than your run-of-the-mill secret identity... The Green Turtle was the first Asian American super hero.The comic had a short run before lapsing into obscurity, but the acclaimed author of


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Long-time friends Malanga, Nisivoccia reunite at All-Star Classic
UNION – Frank Malanga and Vincent Nisivoccia are longtime friends, going back to their middle school days in Nutley. They also played youth football together and were extremely close. "Our mothers are best friends," Nisivoccia said. "We definitely grew up together." But when it came time to go to high school,… Continue Reading


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Can anyone that attended the annual meeting confirm that when asked about the future of the JDI contract for the iPhones, management said that it seems likely JDI will be moving to another supplier who can produce for a lower cost in the near future?
I believe the Apple business was a great shot in the arm for NTE. The company was able to update it's facilities, shore up it's balance sheet (which was never really in trouble), and demonstrate to shareholders that they are capable of doing top quality work for top clients. I applaud NTE for standing their ground on margin and I believe there are opportunities with other customers who require quality and don't have the same stranglehold on suppliers.
I believe management has demonstrated the ability to operate on a string if needed (even during the roughest times during the past couple of years they rarely ran in the red) so I'm willing to wait for them to find the next and possibly better opportunity.
What I can't get over is how smart the market can be sometimes. I'm not a very seasoned value investor and I just couldn't understand why this stock wasn't selling higher with the yoy numbers they were putting up and projected volumes to come. I wonder how many times I will have to review the "if something looks too good to be true" lesson?
That's not really new news. From their May 10 press release it already said "This new purchase order does not alter the customer's decision to eventually transfer its future orders to other suppliers with lower assembling charge."
Of course it will, eventually. Tell us when else you have said nothing.


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Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness
A Systematic Review and Meta-Analysis
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Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association.
Methods and Results— Using a prespecified search strategy, we identified 8 relevant studies and compared study design, measurement protocols, and reported data. We identified sources of heterogeneity between studies. The assumption of a linear relationship between IMT and risk was challenged by use of a graphical technique. To obtain a pooled estimate of the relative risk per IMT difference, we performed a meta-analysis based on random effects models. The age- and sex-adjusted overall estimates of the relative risk of myocardial infarction were 1.26 (95% CI, 1.21 to 1.30) per 1–standard deviation common carotid artery IMT difference and 1.15 (95% CI, 1.12 to 1.17) per 0.10-mm common carotid artery IMT difference. The age- and sex-adjusted relative risks of stroke were 1.32 (95% CI, 1.27 to 1.38) per 1–standard deviation common carotid artery IMT difference and 1.18 (95% CI, 1.16 to 1.21) per 0.10-mm common carotid artery IMT difference. Major sources of heterogeneity were age distribution, carotid segment definition, and IMT measurement protocol. The relationship between IMT and risk was nonlinear, but the linear models fitted relatively well for moderate to high IMT values.
Conclusions— Carotid IMT is a strong predictor of future vascular events. The relative risk per IMT difference is slightly higher for the end point stroke than for myocardial infarction. In future IMT studies, ultrasound protocols should be aligned with published studies. Data for younger individuals are limited and more studies are required.
Received March 23, 2006; accepted November 29, 2006.
Carotid intima-media thickness (IMT) is an intermediate phenotype for early atherosclerosis. Because it can be measured relatively simply and noninvasively, it is well suited for use in large-scale population studies. Ultrasonic measurements correlate well with histology,1 and increased IMT is associated with vascular risk factors2–12 and the presence of more advanced atherosclerosis, which includes coronary artery disease.2–5,7,10,12 IMT is being increasingly used for risk stratification in individuals and as an end point in intervention studies. An important precondition for this application of IMT is that it can predict future risk of clinical vascular events. A number of longitudinal studies have examined the relationship between IMT and future events, most frequently the incidence of cardiac events (myocardial infarction [MI], angina pectoris, coronary intervention) and cerebrovascular events (stroke or transient ischemic attack [TIA]).2–12
Clinical Perspective p 467
Different longitudinal studies have used different measurement methods and studied different populations. Furthermore, some studies have investigated relatively small populations, which resulted in large confidence intervals (CIs) for the risk estimates. We carried out a systematic review of the literature to provide an overview of the relevant studies, critically appraise the methods used, and where possible perform a meta-analysis to gain more robust estimates of the predictive value of increased IMT for clinical cardiovascular end points.
Study Selection and Data Collection
Data sources were identified with a Medline search and a manual search of the citation lists of the relevant publications. Key words for the Medline search were carotid intima media thickness or carotid intima media thickening and stroke or myocardial infarction or death. In a second Medline search, we identified reviews on IMT and checked them for relevant citations. Key words included review and carotid intima media thickness or carotid intima media thickening. Studies were considered to be relevant if the sample was general-population based (and not a specific risk population), if carotid IMT had been measured, and if subjects had been followed up for vascular clinical end points. If the desired results, ie, relationship between IMT and prospective risk of vascular events, were not reported in the publications identified, we searched for additional publications by study/author name. The search was carried out on January 31, 2006.
If the publications did not contain the full information necessary for meta-analysis, we obtained the missing information directly from the authors (see Acknowledgments). The National Heart, Lung, and Blood Institute in the United States provided the original data (limited-access dataset) of the Atherosclerosis Risk in Communities (ARIC) study, from which the hazard ratios (HRs) were newly calculated for uniformity of the estimates. Exclusion criteria and end point definitions were applied exactly as stated in the publications, but because the available dataset contained a later follow-up, the number of events is higher than in the publications (Table 1).
Statistical Analyses
The HRs and CIs of comparable studies were illustrated with forest plots. Pooled estimates were calculated with a random effects model as recommended by Blettner et al,13 with the method of moments approach from DerSimonian and Laird.14 Different standard deviations (SDs) of IMT distributions can be caused by population properties (eg, different age distributions12) or properties of the ultrasound technique (eg, reproducibility), or a combination of both aspects. If one assumes that the populations in the different studies share the same underlying IMT distribution and the same hazard function, then different SDs of IMT measurements are likely to be the result of measurement error, and the risk per IMT difference of 1 SD can be compared without conversion. On the other hand, if we compare populations with different baseline hazards that are influenced by a common IMT hazard function, we have to compare HRs per absolute IMT difference. We decided to implement both strategies: to compare HRs per 1 SD and those expressed as HRs per (absolute) 0.10-mm difference.
To ensure uniformity of estimates, we compared HRs that were adjusted by age and sex. Because the publications from the ARIC study4,6 were stratified by sex, we recalculated age- and sex-adjusted HRs from the original dataset (see Study Selection and Data Collection). To compare fully adjusted models, we tried to gain uniformly adjusted HRs by recalculation of our own datasets (M.R. for the Malmo Diet and Cancer Study [MDCS], M.B. for the Rotterdam Study, and M.W.L. for the Carotid Atherosclerosis Progression Study [CAPS]) and the ARIC data, and by personal communication with the other authors.
From every study, the HRs per IMT difference were log-transformed to obtain symmetric CIs. The standard error of this point estimator was recalculated for every study by log-transformation of the 95% CI limits. The difference between the log(lower limit) and log(upper limit) was divided by 2 × 1.96 (the 97.5% normal percentile) to obtain the standard error. The point estimator from every study was weighted with the inverse of the square of its standard error to calculate compound estimators. To investigate heterogeneity, we used the I2 statistics provided by Higgins et al.15 To identify study variables that contributed particularly to heterogeneity, we performed a meta-regression analysis with restricted maximum likelihood estimates that accounted for residual heterogeneity, as recommended by Thompson and Sharp.16 To assess possible publication bias, we used a nonparametric iterative trim-and-fill procedure suggested by Duval and Tweedy.17,18
The reporting of HRs per IMT difference is based on the assumption that there is a linear relationship between IMT and hazard (in the strict sense, a relationship implied by a linear model is log-linear but is mostly referred to as linear4,6). To reassess this assumption with reference to the publications of interest, we used a graphical technique introduced by Chambless et al.4,6 The relative hazards for vascular events are plotted against baseline IMT for a set of 3 to 6 IMT categories and compared with the assumed linear relationship. Because the IMT cut points must define large proportions of the samples, they depend on the distribution and cannot use the same reference category. The relative hazards for the IMT categories were recalculated or taken from the publications, and the mean IMT values for every IMT category were acquired from the corresponding author directly.
The recalculation of the ARIC, MDCS, and CAPS HRs and the meta-regression were performed with SAS (The SAS Institute, Cary, NC). Forest plots were produced by a Microsoft Excel macro program provided by Peter Rothwell and Enrico Flossmann and modified by M.W.L. Intraclass correlation coefficients were recalculated with SPSS 11.5 (SPSS Inc., Chicago, Ill). The trim-and-fill procedure was calculated manually with assistance of an Excel spreadsheet. M.W.L. had full access to and takes responsibility for the integrity of the data. All authors have read and agree to the manuscript as written.
We identified 8 observational studies with general population-based samples for which carotid IMT was measured and follow-up for clinical end points was provided. For the analysis, we focused on the data given in 12 publications on these 8 studies,2–12,19 which represent 37 197 subjects.
Table 1 provides an overview of the studies in terms of the study design, definition of clinical end points, observed population, sample size, follow-up period, carotid segments studied, definition of IMT, model construction (which accounts for potential bias factors), and report of results. The studies exhibited considerable variation in all of these aspects. In particular, there are marked differences in age distribution, with a lower limit that ranges from 1912 to 75 years.19 Furthermore, the publications can be divided into 2 categories: those that use mean carotid IMT, determined from a number of IMT measurements at specific positions or by automated software over a segment of the artery, and those that use maximal carotid IMT. The Rotterdam Study is the only one in which IMT was determined by both methods in the same population.7,8
For further analyses, the Kuopio Ischemic Heart Disease Risk Factor Study,2 the study reported by Kitamura et al,9 and the Longitudinal Investigation for the Longevity and Aging in Hokkaido County19 were excluded because they did not provide estimates that were comparable to the other studies.
Assessment of Potential Sources of Heterogeneity and Confounding
To determine the comparability of the populations, we calculated event rates (events per 1000 person-years) and absolute common carotid artery (CCA) IMT values for all the studies (Table 2). The event rates show distinct differences that may be largely attributable to the definition of end points. Maximal IMT was more or less comparable in terms of mean values, but the SDs were different. Mean IMT values were similar, but values from different studies exhibited different distributions.
The study design was longitudinal in all publications apart from those by Bots et al and Iglesias del Sol et al,3,7 who used a nested case-control design and a case-cohort design, respectively. The work by Iglesias del Sol et al7 was analyzed with the longitudinal studies, as the Cox regression model estimators of a case-cohort design are comparable with those of a longitudinal design.23 The publication by Bots et al3 was omitted because it refers to the same population as the other 2 publications on the Rotterdam Study and has a study design that provides results that are somewhat difficult to compare with those from longitudinal studies.
Figure 1 illustrates the definitions of the carotid segments for each study. This is obviously a major source of heterogeneity, because, between some studies, the "same" segments do not even overlap. Furthermore, the publications differed in terms of how the results were reported (Table 1). The majority of studies reported calculations from age- and sex-adjusted models. The most commonly reported estimator was the relative risk (provided as HR) per (linear) IMT difference of 1 SD. Another source of heterogeneity is the reproducibility of the IMT measurement procedures, as shown in Table 2. The reproducibility has clearly improved over time.
By means of a meta-regression analysis (see Methods), we determined the influence of sample properties (mean age, duration of follow-up, mean deviation, and SD of IMT) and measurement properties (maximal or mean IMT, near and far wall versus far wall IMT, 1 side versus both sides, position and length of the examined carotid segment, and reproducibility) on the hazard estimate between studies. The duration of follow-up was the strongest (and the only significant) predictor of the magnitude of the log-HR for stroke per IMT difference (P=0.0424). However, this result withstood neither multivariate modeling nor adjustment for multiple testing.
Assessment of the Relationship Between IMT and Hazard
To challenge the assumption of a linear IMT–hazard relationship, we used the graphical method described above (Figure 2). The confidence bands cross the dashed lines, which indicate that the linear model violates the assumption of linearity in the 2 largest studies4–6 (data not shown). For the majority of populations, the slope of the relationship between IMT and hazard is steeper for low to average IMT values (as can be seen in Figure 2), with the slope for the highest IMT categories being relatively moderate. In most of the studies, however, the linear model corresponds well to the categorized analysis for higher IMT values.
HR per IMT Difference Meta-Analysis
As stated in the Methods, different assumptions of the underlying distributions lead to different reference units of IMT. In Figure 3 we display the risk of MI and stroke in the 5 remaining studies, expressed as HR per CCA IMT difference of 1 SD of baseline IMT. Figure 4 shows the plots that correspond to HR per absolute CCA IMT difference of 0.1 mm. Figures 5 and 6⇓ display the same calculations for the HRs of fully adjusted models. In comparison of the plots, we observed that HRs decrease when adjusted for a complete set of cardiovascular risk factors as compared with age- and sex-adjusted estimates. Furthermore, we can see that the HR per IMT difference is slightly higher for stroke than for MI. The heterogeneity is larger for the estimates of MI risk. In an attempt to reduce heterogeneity by strict selection of studies that used identical, or at least comparable, definitions of the carotid segments (Figure 1), we calculated the overall estimates shown in Table 3. The estimates or relative risk for stroke still remained higher than for MI, and the studies are more heterogeneous for MI.
The trim-and-fill procedure found no evidence of publication bias.
In this systematic review and meta-analysis, we reviewed data from 37 197 subjects who were followed up for a mean of 5.5 years. Our analysis provides data on the use of carotid IMT to predict MI and stroke in the general population. By means of meta-analysis techniques we obtained robust age- and sex-adjusted risk estimates. For an absolute carotid IMT difference of 0.1 mm, the future risk of MI increases by 10% to 15%, and the stroke risk increases by 13% to 18%. The risk for both end points decreased with the number of adjustments for risk factors. The present review also highlights potential difficulties that result from the different methodologies used.
Low Specificity of IMT Location for a Clinical End Point
Most studies that investigated the risk of both myocardial and cerebrovascular end points resulted in similar HRs for both end points. The ARIC study4,6 revealed the largest differences (eg, MI versus stroke risk, 1.13 versus 1.21, translated into risk ratio per 0.10-mm CCA IMT difference, adjusted for age and sex). The Cardiovascular Health Study5 shows a higher relative risk for stroke, too. The other 3 large studies7,8,10–12 resulted in an insignificantly higher relative risk of MI. The difference found in this meta-analysis is just statistically significant, as the CIs do not overlap for the models of HR per SD IMT difference. However, the difference is small. This lack of specificity for the target organ has been described by other authors,5–6 who drew the conclusion that early atherosclerotic changes are noncausal and nonspecific markers of atherosclerotic complications.6
Heterogeneity of Ultrasound Protocols
We determined multiple sources of heterogeneity between the studies. These include the details of the ultrasound protocol, namely the precise definitions of the carotid segments investigated, the use of mean or maximal IMT, the measurement of near and far wall or only far wall IMT, and whether IMT was measured only on 1 side or on both sides. Reproducibility has improved considerably over the past decades. The study populations differed with respect to age distribution, selection criteria, and length of follow-up. With the exception of the duration of follow-up, none of the sample and measurement properties significantly explained the heterogeneity between the studies. The fact that parameters such as the position of the carotid segment (Figure 1) do not significantly influence the hazard estimate puts the multiple differences between the ultrasound protocols into perspective. However, with only 5 studies to compare, the statistical power of the meta-regression is limited.
There are good arguments for and against each IMT measurement protocol used. Nevertheless, we strongly recommend the use of a standardized protocol for future studies. A recent consensus paper24 has given some guidance on this. It is noteworthy that this consensus paper recommends measurement of IMT in plaque-free areas. The ultrasound protocols of the epidemiological studies discussed in the present study do not explicitly state how to deal with plaques, but, given that all of them use clear anatomic landmarks, it is likely that, in the IMT measurements, plaque thickness would have been incorporated and measurements would not all have been in plaque-free regions. However, in a general population-based survey with low prevalence of plaque, this is unlikely to be a major confounding factor. For epidemiological studies of low-risk populations, we suggest adherence to exact anatomic definitions. Whenever risk populations are surveyed, the consensus paper24 recommendation applies. To ensure clinically meaningful results, we suggest adoption of the ultrasound protocol of one of the large studies mentioned in the present study (Table 1), preferably of a study with a target population similar to that of the intended study. If a single protocol is established in future, it should have demonstrated good reproducibility and a solid database that demonstrates the clinical relevance of IMT measured by this method. Both are true for the measurement and analysis protocol of CAPS.12
Nonlinear Relationship Between IMT and Risk
When IMT is used as a risk predictor, it is often assumed that the relationship between IMT and risk is linear. Our analysis demonstrates that the relationship between CCA IMT and the relative risk of vascular events is not strictly linear in most populations. This deviation from linearity was first observed by the ARIC investigators4,6 and found to be statistically significant for MI (P=0.002 for men, P=0.04 for women)4 and nearly significant for stroke (P=0.08 for men, P=0.06 for women).6 To understand this relationship, we have to be aware of the link with age: Young individuals with increased IMT are at considerably lower absolute risk but higher relative risk of vascular events.12 Furthermore, individuals with a high risk factor load (and consequently higher IMT) are more frequently under a physician's surveillance and pharmacological intervention, which may reduce their individual risk more than the corresponding IMT.
Vascular events are rare in young individuals, which makes IMT particularly attractive as an end point in epidemiological and treatment studies in young populations. The nonlinear relationship has major implications for the design of IMT studies in young populations, as it limits the transferability of the results from older samples. It is of the utmost importance to investigate the actual risk linked with increased IMT. More studies are needed to provide a larger database on the association between IMT and vascular risk in young individuals. As long as the data on the risk in young individuals are limited, we recommend that IMT studies on young populations should adopt the ultrasound protocol of a study that provides prospective data (at the time of submission there was only one such study12) to be able to express the IMT findings as a relative risk of clinical events.
Our review and meta-analysis has a number of potential limitations. First, there is the issue of potential publication bias. We have tried to identify all those studies that calculated the relative risks of future cerebrovascular or cardiovascular events or death that depend on individual baseline carotid IMT. By means of an extensive Medline-based search, we aimed to retrieve all published data. Given that such observational studies require large samples and long follow-up periods to facilitate the detection of a considerable number of events, it seems very unlikely that a study of this dimension will have been published and not identified by our search. The trim-and-fill procedure, a statistical technique to detect imbalances within the data that possibly indicate the existence of unpublished studies, found no evidence of such an imbalance in the data discussed here.
Second, the graphical method used to investigate the linearity of the IMT-risk relationship relies on the assumption of section-wise linearity. The exact underlying function is determined by polynomial regression, where the maximal power of the function depends on the number of categories. With a minimum of 3 categories, the spline curves can be second-order, which is sufficient to detect the nonlinearity described. A more complex function may be overlooked.
A third potential limitation stems from the multiple sources of heterogeneity between the studies. To obtain compound estimates, we had to take into account the large number of heterogeneities on the one hand and the possible selection bias on the other. Selection bias could be introduced if the heterogeneities were informative, eg, if the proportion of advanced atherosclerosis and the frequency of plaques in a population could influence the author's decision to report mean or maximal IMT, depending on how well either measurement algorithm accounted for plaques. To account for both problems, we provided calculations and forest plots for both selected and unselected studies.
Fourth, a potential limitation is the use of HR per (linear) IMT difference. The use of categorized data has other problems, as the choice of the cutoff points must not be data dependent to avoid introduction of a new bias factor. For the higher age group, however, the linear model still fits surprisingly well. The results of this meta-analysis must be interpreted with caution if young populations with low IMT are of interest.
We thank Daniel H. O'Leary (Department of Radiology, Tufts–New England Medical Center, Boston, Mass), Richard A. Kronmal (Department of Biostatistics, University of Washington, Seattle, Wash), and Lloyd Chambless (Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC) for generously sharing their data with us. We thank Peter M. Rothwell and Enrico Flossmann (both from the Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom) for supplying the macro program for forest plots. One of our data sources, the ARIC study is conducted and supported by the National Heart, Lung, and Blood Institute in collaboration with the ARIC Investigators. This manuscript was prepared with a limited-access dataset obtained by the National Heart, Lung, and Blood Institute and does not necessarily reflect the opinions or views of the ARIC or the National Heart, Lung, and Blood Institute.
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Murakami S, Otsuka K, Hotta N, Yamanaka G, Kubo Y, Matsuoka O, Yamanaka T, Shinagawa M, Nunoda S, Nishimura Y, Shibata K, Takasugi E, Nishinaga M, Ishine M, Wada T, Okumiya K, Matsubayashi K, Yano S, Ichihara K, Cornélissen G, Halberg F. Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study. Biomed Pharmacother. 2005; 59 [suppl 1]: S49–S53.
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O'Leary DH, Polak JF, Wolfson Jr SK, Bond MG, Bommer W, Sheth S, Psaty BM, Sharrett AR, Manolio TA. Use of sonography to evaluate carotid atherosclerosis in the elderly. The Cardiovascular Health Study. Stroke. 1991; 22: 1155–1163.
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Persson J. Ultrasound and atherosclerosis. Evaluation of methods, risk factors and intervention. Thesis. Malmo, Sweden: Department of Medicine, Lund University, 1997.
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Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M. Mannheim Carotid Intima-Media Thickness Consensus (2004–2006). An Update on Behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis. 2006; 23: 75–80.
Carotid intima-media thickness (IMT) is increasingly used as a surrogate and intermediate end point of early atherosclerosis. With modern ultrasound scanners, IMT can be easily and quickly assessed in clinical routine as well as in clinical and epidemiological research. As several large population-based studies have shown, IMT can predict future clinical events, such as myocardial infarction or stroke, and IMT contains information beyond the classic cardiovascular risk factors. The present work pools the results of the existing studies to improve the precision of estimating the risk that is associated with IMT. With data of 200 000 person-years in 8 studies, we calculated compound hazard ratios for myocardial infarction and stroke and searched for sources of heterogeneity between studies and for important differences respective to study design and ultrasound protocol. We give an overview of the existing longitudinal IMT data and their limitations and attempt to derive consequences for future research.
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- Prediction of Clinical Cardiovascular Events With Carotid Intima-Media ThicknessMatthias W. Lorenz, Hugh S. Markus, Michiel L. Bots, Maria Rosvall and Matthias SitzerCirculation. 2007;115:459-467, published online before print January 29, 2007http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628875
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- Prediction of Clinical Cardiovascular Events With Carotid Intima-Media ThicknessMatthias W. Lorenz, Hugh S. Markus, Michiel L. Bots, Maria Rosvall and Matthias SitzerCirculation. 2007;115:459-467, published online before print January 29, 2007http://dx.doi.org/10.1161/CIRCULATIONAHA.106.628875
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Polo Ralph Lauren on Wednesday posted second quarter results that jumped 31.5 percent to $137 million, or $1.28 a diluted share, from $104.2 million, or 97 cents, in the same year-ago period.
Revenues rose 13.6 percent to $1.17 billion from $1.03 billion, which included a 14.3 percent gain in wholesale sales to $659.9 million and a 14.8 percent rise in retail sales to $444.6 million.
"We are one of the healthiest and fastest growing fashion luxury businesses today. The key to our continued success is our focus, whether it is product and or how we operate our business. And our growth comes from our commitment to consistency that stays true to a single point of view," said Ralph Lauren, chairman and chief executive officer, in a statement.
For complete coverage see tomorrow's issue of WWD.


text: Pot Brownies Shut Down PromAnna North4/05/11 12:52pm54EditPromoteDismissUndismissHideGo to permalinkJunior prom at North Andover High School in Massachusetts came to an abrupt end when four kids got sick from eating pot brownies. Officials are now investigating who brought the weed-laced treats. Says one parent, "It's embarrassing. This is a nice town."


text: yes all the rooms on the ground floor are beautiful and the other floors are disgusting and dirty. The pool is cleaned daily is also lovely and ofcourse mama"s food is delicious and the breakfast is non edible on some days. However all these things are nothing compared to sleeping in the next room or in the same residence as... 更多


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In the U.S., the eight-week streak of oil rig additions came to a halt this week.
Further optimization could lead to better frack designs, stage and well spacing, greater production and ultimately, more profit.
Former Texas Railroad Commission chairman tells EnerCom conference that the nation can do more to help its struggling energy industry.
Analysts' report describes massive amount of maturing, expiring debt facing oilfield services sector.
The company is counting on growing "premium inventory"—wells that generate rates of return of at least 30% at $40/bbl oil— to increase resource potential.
The emerging Paleogene play in the US Gulf of Mexico continues to offer increasing encouragement for major deepwater discoveries, with Chevron confirming a significant find.
Shell's CEO Ben van Beurden says, "there is a lot more to do" in its North American deepwater sectors.
The ministry set the minimum value of additional royalties at 3.1% for contractual blocks one through four, and at 1.9% for blocks five through 10.
Renaissance also said that it has opened its field operations office in Villahermosa, Tabasco, Mexico, which is near the Chiapas blocks.
Any consortia that form will be revealed on Nov. 28, Mexico's National Hydrocarbons Commission said, according to Reuters.
A Pemex official told Reuters that forecast is dependent on new oil production coming from mature onshore fields, mature offshore fields, heavy oil offshore fields and deepwater natural gas fields.
Pemex, which has suffered from a prolonged oil rout, will sell some of its infrastructure assets to First Reserve, but will continue to use them and pay rent.
Enhanced completions onshore and subsea tiebacks offshore are contributing to production gains, but low commodity prices are taking away profit potential.
The North American rig count jumped by 18 this week to 582. The count was 1,089 a year ago.
Canadian drillers added more than a dozen rigs this week, helping to push the North American rig count up by 21 to end the week at 542, according to the latest report from Baker Hughes Inc. (NYSE: BHI). The oil and gas rig counts in Canada each grew by seven to 44 and 50, respectively.
The latest report from Baker Hughes Inc. shows the North American rig count jumped by 14 this week.
The North American rig count ended the week at 507, up 10 from the previous week but down from the 1,001 rigs that were operating a year ago.
The 2017 auctions will follow three auctions that began last year covering both shallow-water and onshore blocks.
Populist Andres Manuel Lopez Obrador would require Pemex take minimum stakes in all future oil contracts, and may also revoke two dozen contracts already signed with oil companies, Reuters reported.
The North American rig count grew by 21 rigs this week, boosting the count to 607.
In all, the number of rigs pumping in North America ended the week at 586, up four from last week.
PJ Valves (PJV) has landed more than £1 million (US $1.3 million) worth of contracts to supply more than 1,000 valves for Maersk Oil's Culzean gas field in the U.K. North Sea, PJV said in a news release.


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David Alaba (Bayern Munich) penalty saved (caught) by Nurberg keeper Schafer!
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Rent Everybody Sees the Ants 1st edition today, or search our site for other textbooks by Frederic Morton. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Books On Tape.
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WISN-AM responds to Belling's "Jewish" remarks
In my column today (second item) WISN-AM (1130) conservative talk show host Mark Belling defends pointing out on the air last week that certain members of the "powerful opposition" to plans for a proposed downtown Marriott Hotel - since approved - were "Jewish."
He prefaced his comments on the air by saying their religion "may be neither here nor there."
But the remarks caused certain members of the MIlwaukee Jewish community to wonder why he mentioned it all. In my column, Belling reasserted his pro-Israel bona fides and the Milwaukee Jewish Council was emphatic that in no way did they consider him anti-semitic.
And yet the issue is sensitive enough that station management released a statement - at my request - on the matter, copies of which were passed along the Clear Channel chain of command.
The statement, from program director Jerry Bott, is below
I am responding your inquiry concerning accounts in various local media that refer – mostly without full context – to a report last week by Mark Belling about opposition to new hotel development in Milwaukee in which he noted a range of shared business and social affiliations among several opposition leaders, including the fact that several share Jewish heritage.
As he noted at the time, his point was that, taken together, the shared affiliations suggested that "they are friends and associates that have worked together."
WISN-AM does not condone nor accept anti-Semitism. Having reviewed this broadcast, we are confident that Mr. Belling did not intend to offend Milwaukee's Jewish community – consistent with his long track record of speaking out against anti-Semitism.
Following this broadcast, Mr. Belling has engaged in constructive dialog with members of the Jewish community about how his words have been interpreted by others, and that dialog includes assurances from community leaders that they "know your record regarding Israel and do not believe that you are anti-Semitic." The management of WISN-AM shares that conclusion.
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text:
Ha Ha Tonka
According to the Missouri State Parks Web site, Camden County's Ha Ha Tonka State Park is a "geological wonderland." You could say the same about the rough-and-tumble rock of the park's namesake band, Missouri's Ha Ha Tonka. With whispers, shouts, blazing guitar riffs, soaring four-part harmonies, and an affinity for the Southern gothic, the Springfield four-piece makes music as textured as Missouri terrain. The band is at its best when it ventures beyond radio-ready rock and digs deeper into old-time folk and gospel roots. The results are sometimes softer (the creepy "Hangman," an a cappella rendition of a traditional tune) and sometimes stranger ("Caney Mountain," the story of a traveling preacher who murders a young girl). Ha Ha Tonka's sound is rooted in the land and history from which the band comes.
Sat., Aug. 21, 8 p.m., 2010
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Olympic ring display fails during Sochi Games Opening Ceremony
How do you say "oops" in Russian?
During the Opening Ceremony for the 2014 Winter Games in Sochi, Russia, what was intended to be an impressive display went a little haywire.
Five snowflakes were supposed to open into the Olympic rings, one of the most universal symbols on the planet.
The problem? One of the rings did not feel like cooperating, leaving the world-renowned symbol looking like this:
The likely technical malfunction is just another leaf in the pile of comedic errors that are the Sochi Games. Many journalists have taken to Twitter to complain about the conditions of both the city and hotels and a Twitter feed dedicated solely to criticizing Sochi has already claimed more than 243,000 followers.
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text: Brixham is a small fishing town and civil parish in the county of Devon. Brixham is at the southern end of Torbay, across the bay from Torquay – fishing and tourism are its major industries. The town is hilly, and built around the harbour which remains in use as a dock for fishing trawlers. It has a focal tourist attraction in the replica of Sir Francis Drake's ship the Golden Hind which is permanently moored there.