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Courtney is an FEI/CDI dressage trainer and competitor whose methods encourage balance, strength and confidence of both horse and rider. Based out of the area's premier dressage facility, CB Walker Stables, Courtney Bolender Dressage is located in Bedford Hills NY. Courtney welcomes students and horses at all levels of training.
Phone: 845-797-4419 email: email@example.com
Phone: 845-797-4419 email: firstname.lastname@example.com
June 2016- Please join us for our upcoming Henk van Bergen clinic, June 23-24 at our new location in Bedford Hills, NY. Auditors are welcome, $25.00 per day or $40.00 for both days.
September 2015 - Training with the best! September 1,2, and 3 we welcomed Henk van Bergen back. September 12-13 we are fortunate enough to work with Lars Petersen again to build on the continuous learning that takes place with CBD!
June 2015 - CBD had a very busy month! Courtney and her students came away from HITS well into the ribbons! They came home to welcome Lars and have another great clinic learning from one of the greats!
May 2015 - Courtney and her students came away from their first show of the season proving that the immense hard work and dedication over the Winter was well worth it! See the results page for more information!
Congratulations to Courtney for earning her USDF Silver medal!
February 2015 - Henk van Bergen was here for another fantastic clinic. He was thrilled to see our horses' steady improvement since last time and can see all of the hard work and training going on as we look forward to our Spring shows!
Balance - Stability - Core workshop was again, a lot of fun and very educational. See the events page for more information!
November 2014 - Lars Petersen gave everyone wonderful insight, perfect exercises and impeccable instruction at his clinic this month!
October 2014 - Our fix-a-test with Judge Ann Guptill was fun and educational all wrapped up in a great day! All participants gained valuable knowledge on how to improve their tests as well as tips and exercises to work on during every day riding.
Once again, everyone received an outstanding learning experience when Henk came this month. Some new clients took advantage of being able to ride with Henk and now are hooked!
Courtney rode her own horse Steele, in a clinic with German master Christophe Hess. Both came home excited to begin the next phase of training. Video coming soon!
September 2014 - Courtney attended Dressage at Devon and had beautiful rides all around!
CBD and Co. rocked NEDA's Fall Festival! Great job everyone!
August 2014 - Even with a very large number of participants at HITS, Courtney and her clients had a very rewarding show!
July 2014 - Another successful show at GMHA by Courtney and her clients!
June 2014 - Courtney attended Windy Hollow and HITS. She brought home many ribbons as did her clients. Personal bests were earned and smiles were worn by all!
May 2014 - Ann Guptill gave everyone techniques to fix issues that arose in the test or just tips to make it stellar. A great way to start the show season! See more on the Events page.
Another great clinic by Henk van Bergen!
CBD had great success at HITS! See show results for more information.
March 2014 - Courtney's Core and Balance Workshop was a great success! See more on the Events page.
February 2014 - Henk van Bergen gave a wonderful clinic and helped to gear everyone up for the Spring show season!
January 2014 - Courtney just returned from Florida where she attended the Succeed/USDF Trainer's Conference featuring Steffen Peters and Scott Hassler. She brought home an abundance of insight and great information to pass on to her students and horses!
Courtney Bolender Dressage is proud to be sponsored by Triple Crown Nutrition
Upcoming Events
September 12-13 - Lars Petersen Clinic
Show Schedule 2015
May 16-17 - HITS I Saugerties, NY
June 13-14 - HITS II Saugerties, NY
July 23-26 - GMHA Dressage Days South Woodstock, VT
August 13-16 - HITS on the Hudson Saugerties, NY
September 17-20 - NEDA Fall Festival Saugerties, NY
September 29 - October 4 - Dressage at Devon
Show results click here


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Senior Software QA/QE Centennial, CO
6+ Months Contract Installs, maintains, and monitors the operation of servers in support of the business. Evaluates, designs, implements and maintains server architecture, operating systems, system security and server hardware. Troubleshoots hardware and operating system problems. Evaluates vendor products in hardware and software. Recommends purchases consistent with organizational standards. Provides routine system administration support such as setting up user accounts on servers, server monitoring, system backups, incident, change and configuration management. Provides application installation and customer support. Seeks out opportunities for continuous improvements, automation and cost reduction. *Duties and Responsibilities:* The Software Quality Engineer for Platforms is responsible for analyzing, testing, and resolving technical issues to ensure that developed artifacts meet the design specifications and are within client standards. • Guides the planning, creation and execution of automated tests. Understands the concepts behind and when to do automation. • Facilitates troubleshooting and solves problems. • Investigates and reports project issues by communicating with the team. • Analyzes and ensures requirements/User Story acceptance criteria are acceptable for test case creation. • Automates test cases, as well as performs back end data validation. • Tracks test progress and results in test management tools. • Identifies opportunities, then leads the roll out of inventive tech ideas and implements solutions with the team. *About You:* We're looking for passionate test engineers with a hunger to learn and adapt to new technology quickly. We demand people who are naturally curious, can self-start and share learnings and outcomes effectively with a distributed team. *Things We Expect You to Know:* Extensive operations experience in either Linux or Windows operating systems Hands on experience with cloud technology (AWS, OpenStack, Azure etc…) An understanding monitoring tools, approach and implementation Solid working experience of continuous integration practices & tools (Jenkins, Travis CI etc…) How to write rigorous test cases for your code and use automated test frameworks for them An established history of working in agile teams How to collaborate with a globally distributed team of engineers Demonstrated working proficiency of one of the following languages: Python, Ruby, Java, or C++ Our Tools of the Trade Docker Kubernetes Terraform Vault Consul Keycloak Fabric8 Jenkins HP ALM and/or UFT Selenium TestNg/JUnit Git NGINX Go Java/NodeJS Python Hubot/CoffeeScript AWS OpenStack HP Loadrunner Apache JMeter Maven Desirable Skills Identify, recommend and implement mitigation strategies to keep project work on track Ensure integration testing is conducted *Expert experience or knowledge required in the following:* SQE process, SQE documentation, Agile development methodology, and testing Intermediate experience or knowledge required in: Understanding of Coding Fundamentals (variable declaration, program flow, functions, error handling, etc) Understanding of Web Services (SOAP, REST) Familiarity with automated testing tools (TravisCI). Strong working understanding and implementation practice of software development life-cycle and testing tools. Ability to learn and actively seek new skills and knowledge to keep up with the changing technology field Personal Skills Ability to think outside the box, adapt to circumstances, learn from co-workers, and share information and experiences Ability to be flexible and adapt to any given situation Ability to perform multiple tasks concurrently Excellent customer service attitude, communication skills (written and verbal), and interpersonal skills Excellent organizational and time management skills Excellent analytical and problem-solving skills Ability to make timely and sound decisions Detail oriented Ability to work independently and mostly in a team based environment Ability to work efficiently in a fast paced environment Show accountability and end to end ownership English as a business language Thanks & Regards, Rani Adari Tech Tammina 203 Elden Street Herndon, VA-20170 Call: 703-880-4992 Fax: 703-991-5532 r...@tammina.com www.tammina.com GTalk:raniadarii An ISO 9001:2008 Certified Company -- You received this message because you are subscribed to the Google Groups "DotNet Architect" group. To unsubscribe from this group and stop receiving emails from it, send an email to dotnet_architect+unsubscr...@googlegroups.com. To post to this group, send email to email@example.com. Visit this group at https://groups.google.com/group/dotnet_architect. For more options, visit https://groups.google.com/d/optout.

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|Publication number
|Publication type
|Application number
|Publication date
|Sep 8, 1992
|Filing date
|Oct 28, 1991
|Priority date
|Oct 28, 1991
|Fee status
|Also published as
|Publication number
|Bacchan S. Aswal, Ramesh Chander, Sunil K. Chatterji, Bhola N. Dhawan, Yogesh Dwivedi, Narendra K. Garg, Poonam Jain, Narinder K. Kapoor, Dinesh K. Kulshreshtha, Bishan N. Mehrotra, Gyanendra K. Patnaik, Ravi Rastogi, Jagat P. S. Sarin, Krishna C. Saxena, Shekhar C. Sharma, Shri K. Sharma, Binduja Shukla, Pradeep K. S. Visen
|Original Assignee
|Council Of Scientific & Industrial Research
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (8), Referenced by (14), Classifications (12), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to a process for the preparation and composition of a fraction, mainly containing picroside I and kutkoside (designated by us as picroliv), from the plant Picrorhiza kurrooa as well as the biological activities of picroliv viz. hepatoprotective, choleretic, anticholestatic, anti-hepatitis B virus like and immunostimulant.
Picrorhiza kurrooa is an erect perenial herb about 15 to 25 cm high, growing in Alpine Himalayas from Kashmir to Sikkim, 9,000-15,000 ft. The common trade and vernacular name of the herb is kutki (R. N. Chopra et al., Indigenous Drugs of India, 182, 1958). The root has a bitter sharp taste and is a valued drug for liver complaints and biliousness. (K. R. Kirtikar et al., Indian Medicinal Plants III, 1825-26, 1933).
The ever increasing environmental pollution, exposure to industrial toxicants, food adulteration, malnutrition, unjudicious use of drugs, excessive consumption of alcohol and certain infections lead to various kinds of liver disorders. This poses one of the major challenges in the health care programmes of any country developed or under developed. Present however, no effective therapy is available for the treatment of various liver ailments.
Picroliv is a standardised fraction of the ethanolic extract of Picrorhiza kurrooa. It consists of (a) 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy 1a (hydroxymethyl)-oxireno[4,5]cyclopenta(1,2-c)pyran-2-yl-6-(3-phenyl-2-propanoate), [1aS-(1aα,1bβ,2β(E),5aβ,6β,6aα)]-β-D-glucopyranoside (picroside I) (b) 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a[(4-hydroxy-3-methoxybenzoyl)oxy]methyl]oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside(kutkoside) (c) a fraction (named as F006) containing 4-5 cucurbitacin glycosides and (d) an intractable mixture of other minor unidentified substances, the amount of (a) and (b) ranging from 50-70%, the ratio of (a) and (b) being 1:1.5 to 1:2, the amount of (c) being 4-5% and that of (d) 26-45%. Elution profiles of picroliv and cucurbitacin glycoside fraction (F006) on HPLC on C-18 reverse phase column using a solvent system acetonitrile:water:acetic acid (25:75:0.5) are given in FIGS. 1 and 2 respectively.
Process for the preparation of picroside I and kutkoside individually in a mixture from the plant Picrorhiza kurrooa is known. The fraction containing cucurbitacin glycosides from picroliv was prepared and designated by us as F006. Picroliv was saponified by stirring with a saturated solution of barium hydroxide for six hours followed by extraction with ethyl acetate. The organic layer was washed once with sodium bicarbonate solution followed by two washings with water, dried over anhydrous sodium sulphate and evaporated. The residue contained mixture of cucurbitacin glycosides (F006). One of the cucurbitacin glycosides present in picroliv was isolated by column chromatography over silica gel using ethyl acetate and mixtures of ethyl acetate containing various proportions of methanol as eluant. Ethyl acetate:methanol (9:1) eluate gave an impure cucurbitacin glycoside which was further purified by preparative thin layer chromatography over silica gel plates using ethyl acetate:methanol (9:1) as the solvent system. The pure compound was identical with 25-acetoxy-2β-D-glucopyranoxy-3,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-22-one (III) reported by Laurie et al. (Phytochemistry 24 (1985), 2659).
Rastogi et al. (J. Sci. Ind. Res., 8B (1949) 173, 18B (1959) 219) reported the isolation of a bitter glycoside, named as kutkin, along with vanillic acid and mannitol, while Rastogi et al. (J. Sci. Ind. Res., 14B (1955) 512) characterised kutkin as 6-cinnamoyl-β-D-glucosidovanillate, Basu et al. (J. Org. Chem., 35 (1970) 3159) assigned it 4'-cinnamoyl vanilloyl glucoside structure. Rastogi et al. also attempted the synthesis of kutkin (J. Sci. Ind. Res., 18B (1959) 522). Kitagawa et al. (Tetrahedron Lett. (1969) 3837; Chem. Pharm. Bull. 19 (1971) 2534) isolated picroside I and characterised it as 6'-O-cinnamoyl catalpol. Later B. Singh et al. (Indian J. Chem. 10 (1970) 29) found that kutkin was a mixture of picroside I and another glycoside designated as kutkoside. Kutkoside was characterised as 10-O-vanilloyl catalpol. Klaus et al. isolated two more glycosides viz. picroside II (6-O-vanilloyl catalpol) and picroside III (6'(4-hydroxy-3-methoxy cinnamoyl)catalpol) from the plant in addition to a mixture of 6-cinnamoyl-α- and 6-cinnamoyl β-D-glucopyranose which are presumably formed by the cleavage of picroside I during work up (Ann. Chem. 759 (1972) 173; Ann. Chem. (1977) 1053). Isolation and characterisation of fifteen more cucurbitacin glycosides and an aglycon are also reported from this plant (Hermann Stuppner et al., Planta Med. 55 (1989), 559; Hermann Stuppner et. al., Phytochemistry, 29, (1990), 1633; Hermann Stuppner et. al., Phytochemistry, 30, (1991), 305).
German patent No. 2.203,884 reports a process for the isolation of picroside II (1a,1b,2,5a,6,6a hexahydroxy-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl)oxireno[4,5]-cyclopenta[1,2-c]pyran-2-yl[1aS(1aα,1bβ,2β,5aβ,6.beta.,6aα)]-β-D-glucopyranoside).
It has been observed by us in the paper entitled `Hepatoprotective activity of kutkin, the iridoid glycoside mixture of Picrorhiza kurrooa, published in Indian J. Med. Res., 87 (1988) 401, that the alcoholic extract of the root and/or rhizome of Picrorhiza kurrooa showed significant hepatoprotective activity before the chromatographic separation of the individual compound picroside I and kutkoside. It was also disclosed in the said paper that the mixture of picroside I and kulkoside i.e. kutkin exhibited higher hepatoprotective activity as compared to the individual compounds. So far no process has been described to isolate a fraction from the plant Picrorhiza kurrooa having hepatoprotective choleretic, anticholestatic, antihepatitis B vial and immunostimulant properties. The objective of the present invention is to provide a process for the preparation and composition of a fraction from the plant Picrorhiza kurrooa having hepatoprotective choleretic, anticholestatic, anti-HBs Ag like and immunostimulant properties without employing chromatographic methods. The fraction obtained by the process of the present invention has the property to prevent hepatotoxicity and also exhibit significant immunostimulant properties in humans and experimental animals and therefore is useful in the prevention/treatment of liver damage produced by various hepatotoxic agents and in the treatment of infective hepatitis and other related hepatic infections.
The main finding underlying the invention is that by a process of fractionation with different polar solvents of the alcoholic extract of the root and/or rhizome of Picrorhiza kurrooa a fraction is obtained, which mainly consists of a mixture of pharmacologically active picroside I and kutkoside in an amount of 50 to 70%, the ratio being 1:1.5 to 1:2 and a mixture of cucurbitacin glycosides to the extent of 4 to 5% along with other unidentified substances in an amount 26 to 45%.
Picroliv is light yellowish brown amorphous powder, bitter in taste. It is insoluble in hexane, benzene and chloroform, soluble in acetone, ethanol, methanol and water. Picroliv has shown a potent hepatoprotective, choleretic, anticholestatic antihepatitis B viral as well as immunostimulant activities. The hepatoprotective activity of picroliv has been evaluated against hepatic damage induced by various agents viz. galactosamine, paracetamol thioacetamide, carbon tetrachloride, lanthanum chloride, monocrotaline, ethylalcohol, aflatoxin, Amamita phalloides toxin, cycloheximide in rat and Plasmodium berghei infection in mastomys. The assessment of activity was based on the changes brought about by the hepatotoxic agents in various serum and tissue biochemical parameters (Table 1) and also by histopathological examination of liver. Picroliv brought about 48 to 100% reversal of changed parameters at doses varying from 3 to 12 mg/kg p.o.�7 days (Table 2). The severity of the histopathological changes also became normal in picroliv treated animals.
In the isolated hepatocyte preparation the, hepatoprotective activity was assessed against paracetamol, galactosamine carbon tetrachloride and thioacetamide induced damage. At the dose levels of 1.5 to 12 mg/kg p.o.�7 days, picroliv showed a wide range of protection (Table 3) as evident by reversal of altered biochemical parameters (GOT, GPT and ALP) and increased percentage of viable cells which was determined by Trypan blue exclusion test and oxygen uptake by the cells.
Picroliv showed dose dependent (1.5-12 mg/kg p.o.�7 days choleretic effect in conscious rats and anaesthetized guinea pigs and cats. It produced significant anticholestatic effect against paracetamol, carbon tetrachloride and ethinyl estradiol induced cholestasis and also antagonised to a large extent the reduction in the volume of bile along with the bile contents (bile salts end bile acids) at the dose level of 6 to 12 mg/kg.
TABLE 1______________________________________Biochemical parameters used in the evaluation ofhepatoprotective activityIN LIVERAND SERUM IN SERUM ONLY IN LIVER ONLY______________________________________a) Total proteins Albumen DNAb) Cholesterol Triglycerides RNAc) Phospholipids Lipoprotein-X Glycogend) Acid phos- VLDL + LDL Total lipids phatasee) Alkaline HDL Lipid peroxides phosphatasef) Glutamic Glutamate Succinate oxaloacetate dehydrogenase dehydrogenase transaminaseg) Glutamic Bilirubin Glucose-6-phosphatase pyruvate transaminaseh) Lactate Acid ribonuclease dehydrogenasei) 5'-Nucleotidasej) γ-Glutamyl transpeptidasek) Superoxide dismutasel) Cytochrome P-450m) Cytochrome b5______________________________________
TABLE 2______________________________________Reversal of hepatotoxin induced altered biochemicalparameters by picrolivSl. Picroliv PercentNo. Hepatotoxin (mg/kg po) reversal______________________________________1. Galactosamine 3-12 � 7 25-1002. Paracetamol 3-12 � 7 30-1003. Thioacetamide 3-12 � 7 20-1004. Monocrotaline 25 � 12 70-1005. Aflatoxin B1 25 � 7 25-1006. Lanthanum 25 � 7 30-1007. CCl4 3-12 � 15 15-1008. Amanita phalloides 25 � 10 40-1009. Ethanol 3-12 � 7 40-9010. Cycloheximide 12 � 7 80-10011. Plasmodium berghei 3-12 � 15 10-98 infection in mastomys______________________________________
TABLE 3______________________________________Effect of picroliv on isolated rat hepatocytes(Ex-vivo) Picroliv % ReversalHepatotoxin (mg/kg p.o. � 7) Viability Biochemical______________________________________Galactosamine 3-12 40-100 28-100Paracetamol 1.5-12 35-100 30-100Thioacetamide 1.5-12 18-100 20-100Carbon tetra- 1.5-12 15-100 18-100chloride______________________________________
The effect of long term administration of picroliv to weaning rats was also observed. Doses of 6-12 and 25 mg/kg p.o. were given for 2 months. At the end of the experiment improved growth rate as well as rate of bile flow (12-61%) was observed in the picroliv treated rats as compared to controls. In the picroliv treated animals no change was observed in the fasting blood glucose level and the values of different liver and serum parameters except cytochrom P 450. However, an increased uptake of 14 C glucose, 14 C leucine and 14 C acetate by 80, 30 and 25% respectively was observed in picroliv fed rats (25 mg/kg p.o.) as compared to normal hepatocytes.
Picroliv was tested for the presence of antihepatitis B virus surface antigen (anti HBs) like activity. HBs Ag positive serum samples obtained from hepatitis B virus (HBV) associated acute and chronic liver diseases and healthy HBs Ag carriers were used to evaluate the anti-HBs like activity of picroliv. It was mixed with serum samples and incubated at 37� overnight followed by HBs Ag screening in ELISA system.
Picroliv brought about reduction in HBs Ag titre in 100% serum samples. In case of HBs Ag carriers and cirrhosis patients picroliv (4 mg/ml) showed 4.5 and 4 fold reduction in HBs Ag titre respectively while in the samples from the patient of acute viral hepatitis (AVH) 3.8 fold reduction was observed. Picroliv also affected the HBs Ag titre in 75% serum samples with a mean reduction of 2�0.4 fold.
Picroliv showed reduction in HBs Ag titre after dilution of the antigen in the serum samples. The reduction increased with increasing dilution of antigen samples and reached a maximum at 1:1024 dilution. Picroliv also caused inhibition of purified HBs Ag and HBe Ag. Although in low concentrations (0.1 to 2.0 mg/ml) it had no effect on HBs Ag. But at 2.5 to 4 mg/ml concentration (0.039 μg/ml) HBs Ag was inhibited. Further increase in concentration (5-10 mg/ml) increased HBs Ag inhibition (0.156 mg/ml) but a stepwise dose related response was not observed. In a concentration of 2-6 mg/ml it produced an inhibition of 0.004 μg/ml HBe Ag. With further increase (up to 10 mg/ml) there was only a slight improvement. Thus inhibition of HBs Ag was maximum at 5 mg/ml, while that of HBe Ag was maximum a 2 mg/ml. With both the antigens, increase in picroliv concentration beyond a certain level did not lead to further enhancement in activity.
Picroliv produced an inhibition in HBV-DNA. The extent of inhibition was dependent on the HBV-DNA content in serum samples. Serum samples with low DNA content showed only 4% inhibition on picroliv treatment. In the serum samples with high HBV-DNA (392 μg/ml), 15.7% inhibition was produced by picroliv. Picroliv affected HBV-DNA in 65% serum samples.
The in vivo effect of picroliv on HBV has been evaluated in Pekin duck. The carrier state of the DHBV and its sequlae are similar to HBV infection. The transmission of DHBV occurs vertically similar to HBV infection in man. If the DHBV infection occurs during early period of life just after hatching, the animals become persistently viremic. It is, therefore, possible using this experimental model of HBV to evaluate any compound for interruption of an established carrier state as well as for its ability to prevent development of carrier state. The sets of experiments were planned to screen the effects of picroliv against human hepatitis B virus using Pekin duck as an animal model for both these investigations.
The dose of picroliv was 25 mg/bird, ip daily for a period of 28 days. Based on the initial observations with some of the above products, it was decided to increase the dose to 50 mg per duck daily for a longer period. The dose was given i.p. under aseptic condition. In each set of experiment there were 8 ducks.
In animals which were treated for 28 days (25 mg of picroliv) were followed up for 10 weeks after stopping treatment. With higher dose (50 mg/animal/day), a much longer period of follow-up has been planned. The animals were sacrificed after the stoppage of administration of picroliv at different intervals (4,8,12,16,20 wks). The serum was separated and used for virological studies. During autopsy, major parenchymatous organs (liver, pancreas, kidney, heart and lungs) were collected. The tissues were fixed in buffered formalin and after routine fixation and paraffin embedding the sections were cut and stained with H and E. Since it has been established by in vitro experiments that picroliv binds with the hepatitis B surface antigen present in the serum sample thereby demonstrating anti-HBs like activity. This activity differs from a classical virus neutralization. In order to confirm the in vitro experiments in vivo experiments were carried out.
The DHBV (+) serum sample (200 μl) obtained from persistently viremic duck was mixed with 200 μl of picroliv solution (4 mg/ml). This mixture was incubated in a water bath at 37� C. for one hour followed by centrifugation at 2000 g and used as inoculum for ducklings (50 μl/bird). Two groups of ducklings were used. Group A animals were inoculated with picroliv treated DHBV positive serum sample Group B ducklings (controls) were inoculated with DHBV positive serum sample. The animals were followed for a period of 4 weeks and at the end of the experiment they were sacrificed and the blood was collected for virological studies.
In the ducklings inoculated with the picroliv treated DHBV positive serum samples, 80% did not develop viremia at the end of 4 weeks whereas all the animals inoculated with only DHBV positive serum sample became viremic by this time.
The above findings suggested that in the picroliv treated serum samples binding occurred with the virus thereby making it noninfectious. To evaluate the duration of effect of picroliv after in vitro treatment with DHBV positive serum sample and the DHBV positive serum samples were treated with picroliv for 1, 3 and 6 hours at 37� C. in a water bath and subsequently inoculated to the ducklings which were sacrificed after 4 weeks. It was observed that the duration of picroliv treatment with DHBV did not modify its effects on DHBV infection.
Picroliv possessed marked immunostimulant activity in doses of 5 and 10 mg/kg�7 days as evidenced by PFC assay, HA titre, macrophage migration index, DTM response, macrophage activation and mitogenic response of lymphocytes. A nonspecific immunostimulatory response was also observed against Leishmania donovani infection in mastomys at the dose of 10 mg/kg�7 days of picroliv.
Picroliv was free from any significant CNS, CVS, autonomic and other systemic effects. It produced 42% reduction of paw oedema of rats induced by carrageenin at a dose of 165 mg/kg p.o.
The LD50 of picroliv by i.p. route in mice was found to be 2026.9 mg/kg. By oral route it was 2500 mg/kg in mice and rats. In subacute toxicity study in a 90 day schedule picroliv was found to be safe in rat and monkey.
Although cucurbitacin glucoside (III) was a known compound, its biological activity is reported here for the first time. At a dose of 0.48 mg/kg, it provided significant protection against thioacetamide induced decrease in levels of DNA (94%), RNA (95%) and glycogen (60%) in liver in rat. At higher dose (1 mg/kg) also, it reversed the decrease in levels of DNA (56%), RNA (100%) and glycogen (36%). In addition, toxicant-induced increase in activity of acid ribonuclease and decrease in activity of succinate dehydrogenase were also reversed significantly by the higher dose of cucurbitacin glucoside.
At a higher dose (1 mg/kg) cucurbitacin glucoside showed more marked activity. The activities of γ-glutamyl transpeptidase and cytochrome P450 were significantly restored. The levels of DNA, RNA and glycogen also showed significant reversal. The serum levels of GOT and GPT were restored almost completely towards normal after administration of cucurbitacin.
Cucurbitacin glucoside and fraction, F006, also afforded significant protection against the activities of 5'-nucleotidase (46-56%), acid ribonuclease (48-96%), glucose-6-phosphatase (46-61%) and levels of DNA (55-78%), protein (96-100%) and phospholipids. The decreased level of RNA was completely reversed by F006. The increased level of total lipids showed significant recovery (44-55%) after administration of cucurbitacin glucoside and F006. A significant lowering in the levels of GOT and GPT in serum was observed only with F006, but levels of bilirubin and protein in serum recovered with both the agents.
Cucurbitacin glucoside and fraction F006, at a dose of 1 mg/kg po�15 days, provided marked protection against hepatic damage caused by Plasmodium berghei infection in mastomys as manifested by the reversal of biochemical parameters in both serum as well as liver.
The effect of cucurbitacin glucoside and F006 was also studied on paracetamol-toxicated isolated rat hepatocytes (ex vivo). At the doses of 0.5 and 1 mg/kg po�7. Cucurbitacin glucoside provided 97.4 and 100% protection respectively by Trypan blue exclusion test. The rates of oxygen consumption at these doses were 100%. Fraction F006 also showed significant reversal of the reduced viability of the cells due to paracetamol at the doses of 0.5 mg/kg and 1 mg/kg viz. 89 and 97.2% (Trypan blue exclusion test) and 97.6 and 100% (oxygen uptake test).
Cucurbitacin glucoside and fraction F006 also showed significant choleretic as well as anticholestatic effects. Thus at the doses of 0.5 and 1 mg/kg the increase in the volume of bile was 38 and 90% respectively. Significant increase in bile salt as well as bile acids was also noticed at the above two doses viz. bile salts (40 and 100%) cholic acid (38.5 and 100% ) and deoxychloric acid (47.6 and 100%). With F006 marked increase of 28 and 30% bile flow was noticed at 0.5 and 1 mg/kg doses. Moderate to significant rise in the bile salts (30 and 87.5%), cholic acid (27 and 100%) and deoxycholic acid (22 and 65%) was also found at the above two doses.
The dose of 0.5 and 1 mg/kg po�7 cucurbitacin glucoside completely reversed the paracetamol induced decrease in bile flow, bile salts and bile acids. Fraction F006 afforded complete reversal in all the three parameters (bile flow, bile salts and bile acids) with the doses of 0.5 and 1 mg/kg against paracetamol induced cholestasis.
According to the present invention this is a process for the preparation of a fraction mainly containing (a) 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy 1a (hydroxy methyl)-oxireno[4,5]cyclopenta (1,2-c) pyran-2yl-6-(3-phenyl-2-propanoate), [1a S-(1aα-1bβ,2β(E),5aβ,6β,6aα]-β-D-glycopyranoside (Picroside I), (b) 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a [(4-hydroxy-3-methoxy benzoyl)oxy]methyl]oxireno[4,5]-cyclopenta (1,2-c) pyran-2-yl-β-D-glucopyranoside (kutkoside) and (c) other unidentified substances, the amount of (a) and (b) ranging from 50-70%, the ratio of (a) and (b) being 1:1.5 to 1:2 by weight, the amount of (c) being 30-50%, that comprises.
(i) Extracting the root and/or rhizome powder of the plant P. kurrooa with a polar solvent and partitioning with a mixture of polar solvent and water to form a solvent and an aqueous layer.
(ii) Treating the aqueous layer again with polar solvent or a mixture of polar solvents to form an aqueous layer and a solvent layer.
(iii) Washing the solvent layer with water.
(iv) Treating the washed layer with decolourizing agent such as charcoal.
(v) Evaporating the bleached product to dryness.
(vi) Macerating the dried product with nonpolar solvent for removing less polar impurities.
The extraction of the root and/or rhizome of P. kurrooa may be carried out in any polar organic solvent such as aliphatic alcohol of 1 to 3 carbon atoms, Alcohol is preferred as maximum extraction is achieved in this case. Ethyl acetate is preferred in the step (ii) as it is cheap, non-toxic and non-hazardous and can also be easily recovered and reused. In step (iii) the preferred solvent may be ethanol, methanol, propanol-1, propanol-2, dioxan and the like. The maceration step can be preformed by treating with chloroform or any other non-polar solvent such as benzene, toluene and the like. Coloured impurities in the fraction can be minimised by stirring the solution obtained in step (iv) with active charcoal or with silica gel by just mixing the drug with it in the ratio of 1:2 and then eluting with polar solvent mixture.
The treatment with charcoal is more economical than the treatment with silica gel because of relatively higher cost of silica gel and adsorption of the fraction in silica gel would lead to lower recovery which may be a disadvantage.
We have found that it is also possible to extract the root and/or rhizome of the plant Picrorhiza kurrooa with alcohol and treat the extract with silica gel to form a free flowing solid when the extractive is adsorbed by the silica gel from which the fraction stated above is extracted by treatment with polar solvent. Since the process requires large volumne of polar solvent and costly silica gel it may not be commercially viable.
The process for the preparation of the fraction named by us as picroliv from the alcoholic extract of P. kurrooa having heptatoprotective immunostimulant and virus neutralizing activities is illustrated by the following examples.
(i) Ethanolic extractive (10 g) is dissolved in water (60 ml),
(ii) aqueous solution is extracted with ethyl acetate (6�10 ml) and the ethylacetate layer is discarded,
(iii) the aqueous solution from the previous step is now extracted with ethyl acetate containing 10% ethanol (6�40 ml) and the aqueous layer is washed with water (15 ml) and the aqueous layer is discarded,
(v) the ethyl acetate-ethanol layer from the previous step is treated with charcoal (50 mg) and filtered,
(vi) the filtrate is evaporated to dryness,
(vii) the residue from step (vi) is macerated with chloroform (30 ml) and the solvent is decanted to give a chloroform insoluble product (2.1 g) with a 57% picroside I+kutkoside content.
(i) Ethanolic extractive (10 g) is dissolved in water (50 ml),
(ii) aqueous solution is extracted with ethyl acetate (6�10 ml) and the ethyl acetate layer is discarded,
(iii) the aqueous solution from step (ii) is now extracted with ethyl acetate containing 15% methanol (6�40 ml) and the aqueous layer is discarded,
(iv) the ethyl acetate-ethanol layer is washed with water (3�10 ml) and the aqueous layer is discarded,
(v) the ethyl acetate-ethanol layer from the previous step is evaporated to dryness,
(vi) the residue from step (v) is macerated with chloroform (30 ml) and the solvent is decanted to give a chloroform insoluble product (2.5 g) with 56% picroside I+kutkoside content.
(i) Ethanolic extractive (10 g) is dissolved in a 50% aqueous methanol (15 ml),
(ii) aqueous methanolic solution is extracted with chloroform (2�15 ml and 2�10 ml) and the chloroform layer is discarded,
(iii) the aqueous methanolic solution from the previous step is extracted with ethyl acetate (2�25 ml and 2�15 ml),
(iv) the aqueous methanolic layer from step (iii) is further diluted with 50% aqueous methanol (10 ml) and extracted with ethyl acetate (2�25 ml and 2�15 ml),
(v) the ethyl acetate layer obtained in steps (iii) and (iv) are combined, treated with charcoal (1 g) and filtered,
(vi) the filtrate is evaporated to dryness to give a residue (3.7 g) having picroside I and kutkoside content of 62%.
(1) Ethanolic extractive (50 g) is shaken with 10% aqueous acetone (350 ml), filtered and insoluble portion is discarded,
(ii) aqueous acetone solution from the previous step is diluted with equal volume of acetone followed by addition of diethyl ether (100 ml) and the supernatant is separated from the percipitate by decantation,
(iii) the percipitate is discarded and the supernatant is evaporated to dryness,
(iv) residue obtained in the previous step is dissolved in acetone (120 ml) and a mixture of acetone+diethyl ether (1:1, 60 ml) is added, solution is decanted from the sticky precipitate and evaporated to dryness,
(v) residue from the supernatant obtained in step (iv) is dissolved in acetone and diethyl ether is added, the supernatant is then decanted and evaporated to dryness,
(vi) the process of partial precipitation is repeated six times,
(vii) residue from the final diethyl ether acetone solution is macerated with chloroform and chloroform soluble portion is discarded. The chloroform insoluble portion (9 g) has picroside I+kutkoside content of 64%.
|Cited Patent
|Filing date
|Publication date
|Jul 23, 1981
|Aug 30, 1983
|Willmar Schwabe Gmbh & Co.
|Reactive iridoid derivatives; process for manufacture and application of same
|Mar 22, 1985
|Aug 16, 1988
|Mycogen Corporation
|Compositions containing bacillus thuringiensis toxin toxic to beetles of the order coleoptera, and uses thereof
|Nov 25, 1988
|Sep 19, 1989
|Joseph Gold
|Method of prolonging cancerous patient survival in humans with hydrazine sulfate
|Mar 18, 1988
|Nov 14, 1989
|The Board Of Trustees Of The University Of Illinois
|Volatile attractants for diabrotica species
|Aug 25, 1988
|Jun 25, 1991
|Nestec S.A.
|Process for the preparation of an antioxydant extract of spices
|May 2, 1989
|Sep 17, 1991
|Bar-Ilan University
|Anti-allergic extract
|Nov 21, 1990
|Mar 3, 1992
|Wakunaga Seiyaku Kabushiki Kaisha
|Method for preparing an s-allylcysteine-containing composition
|Jun 8, 1989
|Mar 17, 1992
|Sven Gohla
|Medical preparation containing as active agent a component from thuja plants which comprises polysaccharides
|Citing Patent
|Filing date
|Publication date
|Oct 16, 1995
|Jul 27, 1999
|Choongwae Pharmaceutical Co., Ltd.
|Pharmaceutical preparations which inhibit hepatitis B virus (HBV) replication
|Apr 16, 1997
|Oct 24, 2000
|Dabur Research Foundation
|Hepatoprotective compositions and composition for treatment of conditions related to hepatitis B and E infection
|Feb 12, 2001
|Nov 4, 2003
|The Himalaya Drug Company
|Herbal laxative preparation
|Sep 2, 2010
|Sep 8, 2015
|Munisekhar Medasani
|Picrorhiza extract for prevention, elimination and treatment of infection diseases
|Jul 21, 2004
|Apr 7, 2005
|Sahajanand Biotech Private Limited
|Polyherbal formulation for hepatic and splenic disorders
|Mar 8, 2007
|Nov 29, 2007
|Council Of Scientific And Industrial Research
|Iridoid glycoside composition
|Dec 15, 2004
|May 7, 2008
|Use of kutkin I in preparing drug for treating hepatitis B
|Dec 15, 2004
|Apr 18, 2012
|Method for preparing picroside I
|Feb 3, 2012
|Jul 11, 2012
|Traditional Chinese medicine used for treating hepatitis B
|Feb 3, 2012
|Aug 14, 2013
|Traditional Chinese medicine used for treating hepatitis B
|Apr 21, 1997
|Jan 13, 1999
|Dabur Research Foundation
|A polyherbal pharmaceutical composition useful in the treatment of conditions associated with hepatitis E and hepatitis B virus infections
|Aug 11, 2010
|Oct 2, 2013
|Munisekhar Medasani
|Picrorhiza kurroa extract for prevention, elimination and treatment of dna based viruses in humans and in biotech industry
|Apr 10, 2007
|Oct 18, 2007
|Bar-Ilan University
|Cucurbitacin glucosides and use thereof in treating cancer
|Sep 2, 2010
|Jun 30, 2011
|Munisekhar Medasani
|Picrorhiza kurroa extract for prevention, elimination and treatment of infection diseases
|U.S. Classification
|536/124, 514/893, 514/894, 424/773
|International Classification
|Cooperative Classification
|European Classification
|Dec 9, 1991
Owner name: COUCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH RAFI MA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:ASWAL, BACCHAN S.;CHANDER, RAMESH;CHATTERJI, SUNIL K.;AND OTHERS;REEL/FRAME:005948/0973
Effective date: 19911022
|Jan 25, 1996
|Fee payment
Year of fee payment: 4
|Jan 28, 2000
|Fee payment
Year of fee payment: 8
|Jan 27, 2004
|Fee payment
Year of fee payment: 12


text:
September 25 2013 03:19PM
As the preseason comes to a close and the NHL regular season is squarely on the horizon StreakCred is ready to go with an early bird - $15 for the entire year.
Drawing penalties - Who is good at it on the Canucks?
Cam Charron
September 25 2013 02:59PM
"Draw me like Nazem Kadri draws a tripping penalty" - How the line should have been delivered
This post is mostly related to two vilified wingers of past and future Vancouver Canucks teams, Mason Raymond and David Booth. Both of these players are pretty good at an overlooked part of hockey. At least Raymond was good before his injury sustained in the Finals, but I digress. I've covered Raymond pre-and-post injury enough, and the last thing this website needs is more people talking about how Booth is going to surpass measly expectations.
Powerplay percentages and penalty kill percentages are one thing, but what really matters is how many goals for and against you get in special teams situations. Last year, the Canucks were 8th in PK percentage but 10th in goals against while shorthanded. Why the small discrepancy? Because they took more penalties.
Ouch, That Hertl: Canucks Get Blanked by the Sharks
Dimitri Filipovic
September 24 2013 10:57PM
Andrew Alberts must be a secret agent. It's the only possible explanation for his performance tonight.
The Canucks entered Tuesday night's game in San Jose coming off of an impressive victory against the Coyotes the previous night. Despite a few lineup changes - Higgins, Garrison, and Luongo, most notably - they were still icing a more than competent crew, so there was reason to believe that we'd be treated to a good game.
Early on, the Sedins - reunited with Alex Burrows and it feeeeeeels so goooood - generated a handful of quality chances. They were buzzing. There was also a play where Chris Tanev rang iron with a shot from the point as Jannik Hansen caused a ruckus in front of Antti Niemi.
But then, the direction of the game changed and things sort of went off the rails..
Jensen Train Takes Detour to Utica (Plus An Update on Jordan Schroeder)
Dimitri Filipovic
September 24 2013 02:43PM
Nicklas Jensen is sad, and he doesn't care who knows it. (Image via Flickr )
It appears that the #JensenTrain has been stalled for the time being with the young talented winger reportedly being sent down to Utica to work his way back from a shoulder injury (sustained in last Saturday's game from hell for the Canucks). Meanwhile, Jordan Schroeder, who got hurt in the same game, is expected to miss an extended period of time with an ankle injury that we still don't know very much about.
It's certainly a rough break for both guys, as they each seemed to have a realistic shot at earning a spot on the opening night roster heading into camp.
Some thoughts just past the jump on what that means for both of the young players, and the Canucks, with the regular season opener in San Jose being just over a week away.
We have written 344 posts since we last recapped a win
Cam Charron
September 23 2013 11:01PM
Well, that was fun, I guess. Roberto Luongo won his first game since April 15, stopping 22 of 23 shots in a pretty… uneventful game. The Canucks won 6-1 against Phoenix Monday night for their first preseason win, which was good to get after an 0-3 start, including two pretty weak losses to the Edmonton Oilers. While this doesn't count for anything, a five-goal victory the first night that most of the A-roster is on the ice is fun to get.
Optimism abound? Well, also it was the Phoenix Coyotes, so no need getting super excited about anything.


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Relaxed atmosphere,good and varied menu.Excellent breakfast
Probably a little more attention during dinner service, although young waitress very pleasant.
Free wireless internet with no password required, cleanliness of the room, LCD TV with freeview channels and great breakfast.
convenient and friendly.
the restaurant food in the evening was very poor - the roast chicken had not been roasted but broiled (and tasted horrid) and the vegetarian meal was more like a coarse cuppa soup with very little taste. Breakfast was ok.
Breakfast / location for my needs / car parking
Dinner - menu very poor and expensive and lacked quality. Due to poor selection on the menu meant that I had to dine out the second night of my stay.
The receptionist was very helpfull, welcoming and gave us a more appropriate room (we had booked on line and the only room available was adisabled one) She also took interest in why we were staying and gave us travel details and a number for a return taxi which made things much easier not being local.
There were none
2nd Time booked through Booking .com had no knowledge of my reservation so had to find another hotel for the second day I was due to stay, I will not book a Premier Inn via Booking .com again as i only have issues with the Premier Inn when booked this way
Staff were exceptional, the hotel needs updated, but not offensive. Beds etc really clean, Carpets a bit grubby. but just take your slippers with you. Was really annoyed to learn they used to have smoking rooms, but new Smoke Detectors now being installed, and too sensitive to smoking.We had our supper there and was really good. apart from, Ask the chef to leave the viniger dressing off of all salad etc. I will be on our next visit.
The no smoking, and the Vinigar Dressing on the Prawn Cocktail and my Salad on the main course. It was far too strong. The meal would have been 100% apart from the dressing?
Room has holes in celing!
the rooms and service
the breakfast was diabolical and very disappointing - the swimming pool was too busy
Being at the same Hotel as the Wedding we were going to, breakfast, pool & suna
Comfort of the beds not very good.
It was close to where I was going
I didn't like the room, uncomfortable bed& pillows or the shabby tired room. Will not stay here again
There was nothing bad to report about this hotel, we were extremely satisfied with everything
Good location off M74, good clean rooms, enjoyed complementary glass of wine on arrival - nice touch. Would use again if needing a stop over just outside Glasow
Staff were extremly pleasant and helpful at all times
Would have liked a bigger tv in the bedroom , very hard to see as it was very small
ideally placed for shopping centre
bath badly chipped and rusted
This hotel is great value. Could find very little fault with it. Restaurant is exceptional
We attended a lovely wedding
Bar prices too expensive
The position of the hotel for shopping and visiting friends , the staff were friendly and tried to help with booking breakfast.
The room was clean on arrival- but the soap dispensor did not work ok for the first night but I feel if the maid was doing her job she should have found this and rectified this by the second night also the room had not been cleaned on the second day. Only 2 tea bags for two days with two people in the room this was only a minor niggle but it did make me think I was uninportant to thaaem
It was quiet clean and a good evening break from home the room was comfortable and spacious the location was good and the staff friendly and eager to help the restaurant bar was excellent and again the staff couldn't have been nicer.
Convenient position for accessing the motorways. Onsight catering was very convenient for meeting and entertaining friends.
we found the hotel was how we like it,it was near all the places we wanted to visit.
there was nothing we did not like.
Sink blocker not working. Bed lamp not plugged inn. Telephone not plugged in. No soap in shower dispenser. It seemed like they were,'t prepared for guests!
I enjoyed the peace and quiet and the room was nice and large.
The room was cold and didn't find the heating instructions very good.
It was peaceful relaxing
Price but great clean relaxing place
Staff were very friendly
No covered/heated smoking area.
This was a pleasant surprise as we had never stayed in a premier Inn before - the staff were friendly, the room was larger than expected and there was lots of hot water and a full size bath. Excellent value for money.
Very friendly staff and excellent bar and dining facility.
The room was cold (no temperature control) and had not been fully refurbished. The food (via room service) was warm rather than hot. I had to wait at least 5 minutes for someone to come to reception when I wanted to check-out (there was no buzzer to summon a member of staff). There was no information about the hotel facilities within the room e.g. breakfast times, and the receptionist did not inform me of anything like this when I checked in.
Very convenient for the Town Centre, public areas OK and very reasonable price
The room decor and facilities are very dated
Great room! Plenty of room. Beautifully done. Service was great and people very friendly.
Not enough light in the bathroom!
I have been staying at the Eglinton Arms now for about 12 years and it has always been excellent. As it has been about 18months since I last visited I was concerned that the overall experience would have degraded with the introduction of Best Weston. I need not have worried they have smoothed off all the edges to make this hotel one of the very best around. I travel allover Europe and the UK, this is still my favorite hotel fabulous!
The weather! Everything else is just great.
staff extremely freindly.hotel was fresh and newly refurbished. very comfortable bright rooms well equipped.
difficult to find
Hotel ,downstairs fab.food great,staff really friendly . upstairs still to be refurbished,
I was staying in room 20 and was awake all night ,due to a loud noise which sounded like a fan, was really dissapointing as it spoilt the next day due to lack of sleep. On leaving complained to receptionist, £10 was reducted from bill ( BIG DEAL)
Bedroom was not made up. Bistro table not available for 15 minutes after booking time.
The Reception was closed when I arrived, at 11:00, from a long trip from Germany.
The services station closed at 10pm which is inconvienet if you are in the Hotel late and want something to eat. The woman in the evening shift, at the service station, seemed not willing to help visitors example: a couple of Polish travellers ask for Fish "it is not ready as the fryer was being cleaned" they then asked for Chicken Madras " It is not ready as it is still frozen" (this is 7pm in the evening). The Polish guys just left in discuss.
geat pass through hotel on the way up to the scottish highlands. Nice place to walk the dogs !
Sat Nav (Tom Tom) brought us of the junction before and all around to the back entrance .! a little noisey with the trucks making early starts.
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text:
To portray the meaning of something.
I define the length of that cock as 2 feet.
ayon kay Matteo ika-12 ng Setyembre, 2003
To give a definition for a word, phrase, acronym, or abbrevation.
"I am defined as: "Above all others"
ayon kay Ravek ika-20 ng Marso, 2004
to give a meaning to a word.
How would I define an apple?
ayon kay Anonymous ika-09 ng Setyembre, 2003


text:
Spectacular Ocean Views -2 Storey Penthouse Villa
From $175 / night
Description from the owner
Description from the owner
Bedrooms: 3/
Bathrooms: 4/
Sleeps: 6/
Type: Villa
Book this 3 bedroom, 4 bathroom villa in Puerto Vallarta today! A total of 6 people can sleep here comfortably. This property has been booked 24 times.
Guests can enjoy a pool, , and hot tub among other amenities offered by this rental.
Travelers are sharing their opinions on this property. It has an overall rating of 5/5 thanks to an average of 2 reviews.
Costs vary, with the average weekly rate as low as $1,225.00 to as high as $2,625.00, depending on travel dates.
The owner responds to 100% of inquiries and last updated the property's calendar 2 months ago, so this rental may not be available for your requested dates, but please inquire to confirm.
Proximity to TripAdvisor's Top Puerto Vallarta Attractions
Proximity to TripAdvisor's Top Puerto Vallarta Attractions
Reviews (1)
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text:
2700 East Coast Highway #103
Corona Del Mar, CA 92625
Monday thru Saturday, 10-6
Established in 2015, Heron Haberdashery is the preeminent shopping destination for high quality men's sportswear in southern California. In addition to the Heron Haberdashery brand, the store offers best in class brands such as Anderson's, Belvest, Incotex, Superga, and Zabattigli.
2700 East Coast Highway #103Corona Del Mar, CA 92625949-791-8623Monday thru Saturday, 10-6
© 2016 Cereus Product Development, Inc. All Rights Reserved.


text:
- //Home
- //Music
- //Magic Bullets
Magic Bullets have toured with the likes of Cold War Kids and Voxtrot, and that's no surprise after hearing their debut album. It comes from the same line of poppy post-punk that may not make the indie kids dance, but they'll at least shuffle their feet. Opener "Yesterday's Seen Better Days" showcases Philip Benson's honey-soaked vocals, which, along with Colin Dobrin's drumming, represent the band's strongest selling points. The production is downright Spartan, putting the drums and vocals high in the mix and letting most of the guitar work and bass get lost in the shuffle. This is effective for the most part, but does expose Magic Bullets' melodies as a little weaker than they should be. Tracks like "Lay Low" and "Will Scarlet" are strong pop songs, but much of the album ends up sounding the same. This is the sound of a band getting started, and they've laid a decent enough foundation to build upon.
- "Heatstroke" MP3
- "Yesterday's Seen Better Days" MP3
- Multiple songs MySpace
Donovan Woods "What They Mean" (video) (premiere) // Music
Stewart Eastham "Leavin' By Sundown" (premiere) // Music
Andre Cymone "Hallelujah" (premiere) // Music
Royal Canoe "Bicycle" (video) (premiere) // Music
Grouplove Celebrate 'Big Mess' Release with Wild NYC Shows (Photos)
// Notes from the Road
"On release day for their latest Big Mess, Grouplove packed Baby's in Brooklyn for a sweaty show.READ the article


text:
How To: Make Picture Frame Silk Screens
Michelle SaintOnge's demonstration on Martha today, we might finally be up to the challenge. Her instructions include several pet-inspired templates to use, but of course making your own would be a bit more fun. Have you made a silkscreen print before? Any tips?
Image: t-dot-s-dot
Image: t-dot-s-dot


text:
Silhouette of Yu Narukami (Player Character) and his Persona.
persona 4 persona yu narukami yu player character silhouette black white yellow phone iphone 4s game ps2 nerd nerdy geek geeky atlus shin megami tensei boy man high school student
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Recommended Products for tyre pump:
12 inch inner tube set
kr 200,00
12 inch tyre set
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Tyre pump for the pneumatic wheels of your Mountain Buggy stroller.
FREE shipping on all orders over kr 2.500,00
kr 200,00
kr 360,00
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you are viewing a single comment's thread.
Zoom, you must realize former shareholders who read latest PR sharing "there are a transfer of shares" and "the company is on solid ground." In that wording present share holder are being encouraged to stay long because of solid ground wording. Legal experts will view wording as "baiting" for deception scam. You can not say on solid ground and shares worthless. Agree ....Recent PR......"As of May 1st, Arcadia Services, Inc. has gone through a stock transfer with a newly formed Holding company, Arcadia Holdings II, Inc. With Comerica as the senior lender, Arcadia Services now finds itself under new ownership. The new CEO, John Elliott, has returned after five years to resume operations, focusing on the home care and staffing industry. The stock transfer has allowed Arcadia Services to become a privately owned company once again.Mr. Elliott plans to rebuild momentum lost over the past few years through focus on the home care and staffing industry. Mr. Elliott has stated "Returning to Arcadia for the first time since 2007 has been like coming home. We have the greatest people in the health care industry. For 35 years Arcadia has been exceptionally profitable and we will continue to focus on the business and its growth." The company remains on solid ground and still holds its market share value. The basic organization will remain the same, keeping its headquarters in Southfield, MI, as well as maintaining all employees and affiliates nationally." Also .....Zoom boss .... at present time give them(Zoom and group) a c+. They have discouraged shorts but has no impact on longs. Strengths-Determined, Independent, Visionary, .....Weaknesses - Crafty, Impatient, Rash decision making, would make motivator for "Biggest Loser" but average here.


text:
2012 Sessions Snowboard Pants - Mens2012 Sessions Snowboard Pants are now on sale at Proboardshop.com. Mens 2012 Sessions Snowboard Pants are busting outta our warehouse with super dope color combinations, rugged weatherproofing and awesome style. Sessions is one of the original gangsters of the snowboard industry and they have a reputation to uphold. Sessions Snowboarding held to a higher standard. Proboardshop.com combines 30 years of great prices, selection, and excellent service.
2012 Sessions Snowboard Pants
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Sessions True Denim Snowboard Pants
Size: X-SmallReg: $229.95 On Sale: $137.95
Sessions True Denim Snowboard Pants
Size: Small, MediumReg: $159.95 On Sale: $87.95


text:
How to Make Cold-Brew Coffee
How+to+Make+Cold-Brew+Coffee - Redbook.com
How to Make Cold-Brewed Iced Coffee Concentrate
How to Make Cold-Brewed Iced Coffee Concentrate | kitchentreaty.com
Perfect Iced Coffee
The Pioneer Woman Iced Coffee
MYO: Coffee Concentrate
homemade coffee concentrate make your own iced coffee
MYO: Coffee Concentrate
Make Your Own Iced Coffee Concentrate - lasts in the fridge for a few weeks! Perfect Starbucks alternative!
Perfect Iced Coffee
Pioneer Woman's Iced Coffee: 1 pound Ground Coffee (good, Rich Roast) 8 quarts Cold Water...brewed overnight & strained in cheesecloth= coffee concentrate Half-and-half (healthy Splash Per Serving) Sweetened Condensed Milk (2-3 Tablespoons Per Serving) Note: Can Use Skim Milk, 2% Milk, Whole Milk, Sugar, Artificial Sweeteners, Syrups...adapt To Your Liking!
Iced Coffee with Condensed Milk
This iced coffee is quick (done in 15 min) and tastes way better than the coffee shop version. Keeps well for weeks in the fridge! @natashaskitchen
Perfect Iced Coffee
recipe for making coffee concentrate for iced coffee drinks
Sweet cream for iced coffee. So easy...a 12 oz can of evaporated milk and a 14 oz can of sweetened condensed milk. Mix together and refrigerate.
DIY Cold Brew Coffee Concentrate - no more fussing with clean up every morning! Perfect for Iced Coffee this summer.


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Essential Pepin "Game Day" Venison Steaks In Sweet-Sour Sauce; Skillet Duck With Red Oak Salad; Sauteed Rabbit With Morels And Pearl Onions. D
9:00 pm
America's Test Kitchen from Cook's Illustrated "Rethinking Seafood Classics" NULL
9:30 pm
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10:00 pm
Taste This! "Grand Central Markets" NULL
10:30 pm
Rick Steves' Europe "European Travel Skills, Part 1" Rick begins his favorite 3,000-mile European loop while providing information about essential travel skills. He packs 30 years of travel experience into his practical advice while he is on location in Amsterdam, Germany's Rhineland, Venice, Siena, the Italian Riviera, the Swiss Alps, Paris and London. Part 1 of 3G
11:00 pm
Democracy In America "Federalism: U.S. V. The States" This program explores federalism as a Constitutional compromise, especially in terms of present-day conflicts between people who believe that power should reside primarily in the national government and those who want government authority retained within the states. D
11:30 pm
Democracy In America "Civil Liberties: Safeguarding The Individual" This program examines the First, Fourth, and Sixth Constitutional Amendments to show how the Bill of Rights protects individual citizens from excessive or arbitrary government interference, yet, contrary to the belief of many Americans, does not grant unlimited rights. D


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January 22, 2015 - Industry News
The 52nd annual ATD Convention is taking place at the Moscone Center in San Francisco this week. Awards will be given at the event for the 2015 Truck Dealer of the Year winner on Friday Jan. 23 and the Commercial Truck of the Year on Saturday Jan. 24.
Tags: ATD, Truck Dealer of the Year, Industry Event, ATD Commercial Truck of the Year
November 4, 2013 - Industry News
Senior Editor Tom Berg writes about his experience judging the ATD Commercial Truck of the Year contest.
Tags: Hino, Kenworth, International, Peterbilt, ATD Commercial Truck of the Year
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Steve Carlson from Xantrex, will answer your questions
The expert, Brian Fletcher from Eaton, will answer your questions
Maxion Unveils MaxSmart Wheel-Mounted Sensor
Gates Expands Heavy-Duty Belt Line
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OWL Detects Overhead Obstacles for Oversize Loads


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Welcome to Money Tracker, and to my Personal Budget Coaching and Budgeting Tools!
Think about how your life, your relationships, your job, or your visions for the future could be different if money issues were not dominating your daily thoughts, time and energy.
Know that with patience and commitment,
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Not Quite Human
Release Date: January 1st, 1987
Not Yet Rated|1 hr. 35 min.
Plot Summary
An inventor (Alan Thicke) sends his daughter (Robyn Lively) to high school with his latest creation, an android teen called Chip (Jay Underwood).
Cast: Alan Thicke, Jay Underwood, Robyn Lively, Joseph Bologna, Robert Harper, Brian Cole, Brandon Douglas, Lili Haydn
Director: Steven H. Stern
Genres: Fantasy


text:
Charles was 32, and Lady Diana Spencer was 19 but, as he noted, 'she'll be 20 soon and I was about that age' when he undertook his royal obligations
'The Queen got the corgis to sit in a semi-circle around her, and then fed them one by one, in order of seniority. The others just sat and patiently waited their turn'
Prince 'William and I would not hesitate to seek help for our children if they needed it. We hope to encourage George and Charlotte to speak about their feelings'
The school said he will receive the same treatment as other pupils. The young prince made a quiet arrival, unlike his father, William, who was filmed on his own first day
Meanwhile, Prince Harry disclosed the Royal family 'love it' if official visits go wrong as it makes them more memorable
The queen said there have been 'moments of darkness' in the last year, which has been marked by extremist attacks and a migrant crisis that has overwhelmed Europe
Mark Colborne was convicted of planning terrorism in September. The redheaded British man has been detained indefinitely under mental health laws
The nuclear deal has faced criticism from those who suggest the prime minister has been wooing the Chinese for trade deals while ignoring the country's human rights record
Jeremy Corbyn, a lifelong republican, is known to have reservations about kneeling before the Queen, kissing her hand as he swears an oath of allegiance to her
Spain's new king and queen are sexier and more interesting than the squeaky-clean Duke and Duchess of Cambridge and the future of the monarchy depends on them


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For only $15 a year, your club membership grants you the following benefits:
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Nolan Reimold
|Nolan Reimold
Reimold with the Baltimore Orioles in 2011
|Baltimore Orioles – No. 14
|Outfielder / Designated hitter
October 12, 1983
Greenville, Pennsylvania
|MLB debut
|May 14, 2009, for the Baltimore Orioles
|MLB statistics
(through September 26, 2016)
|Batting average
|Home runs
|Runs batted in
|Career highlights and awards
Nolan Gallagher Reimold[1] (born October 12, 1983) is an American professional baseball outfielder who has been with the Baltimore Orioles of Major League Baseball (MLB) since 2015. This is his second stint with the ballclub; he was previously with the Orioles from 2009 through 2013. He has also played for the Toronto Blue Jays and Arizona Diamondbacks, splitting his 2014 season between the two teams. Reimold has also filled in at designated hitter for the Orioles.
Early life[edit]
Reimold was born to John and Mary Reimold on October 12, 1983 in Greenville, Pennsylvania.[2] He attended Kennedy Catholic High School in Hermitage, Pennsylvania. In addition to baseball, he was also on the basketball team in a traditional football-heavy stronghold of Western Pennsylvania.[citation needed]
Reimold attended Bowling Green State University in Bowling Green, Ohio, the same as former Bowie Baysox teammate Jeff Hundley [3] and Major League relief pitcher Burke Badenhop. Reimold currently holds the career records at Bowling Green State for home runs and runs batted in (RBI).[3] Reimold was an all Mid-American Conference outfielder in 2004, and a 3rd-team All American as a designated hitter in 2005.[4] He was named National Hitter of the Week on March 28, 2005.[2] He led the Mid-American Conference (MAC) in home runs (20), RBIs (60), total bases (137), on-base percentage (.496), and slugging percentage (.770) throughout the 2005 regular season, only to be second in batting (.360) behind fellow Falcon teammate, Andy Hudak.[2]
Reimold was drafted by the Baltimore Orioles as their 2nd round pick (61st overall) in the 2005 MLB Draft. He became the fourth highest Falcon ever drafted and just the third Falcon drafted in the top two rounds. He also became first Falcon ever to be named All-America by three different outlets in one season which were the NCBWA Second Team, ABCA Third Team, Baseball America Third Team.[2] After signing, he played for the Aberdeen IronBirds and Frederick Keys, and was a New York–Penn League all-star for the IronBirds. He continued to play with the Frederick Keys for the 2006 season, and was the MVP for the Carolina League's all-star game. He started the 2007 season with the Bowie Baysox but was sidelined shortly thereafter with an oblique strain. After a brief rehab stint with the Gulf Coast Orioles, Reimold returned to the Baysox to finish the rest of the season.
He continued playing for the Bowie Baysox for the 2008 season, and was named an Eastern League post-season all-star.[5] In game two of Bowie's match-up with the Akron Aeros in the first round of the Eastern League playoffs, Reimold hit three home runs for the first time in his career en route to finishing 4-for-5 with eight RBIs.[5]
Reimold played for the Surprise Rafters in the Arizona Fall League during the 2008 Winter Baseball season.[5] Baseball America named him the 5th-best prospect in the Orioles' farm system for the 2009 season.[6]
He reported to the Norfolk Tides, the Orioles' Triple-A team to begin the 2009 season, and was recalled to the major league club on May 14 collecting his first major league hit that night off Ron Mahay, then would collect his first major league RBI and double, both off Royals pitcher Kyle Davies on May 16. Reimold hit his first career home run on May 20, 2009 against the New York Yankees at Yankee Stadium off Mariano Rivera. On May 27, 2009 Reimold hit his first walk off home run against the Toronto Blue Jays in the 11th inning to give the Orioles a 12–10 victory.
Nolan won the American League Rookie of the Month award for June 2009.[7]
On September 18, the O's decided to shut down Reimold for the rest of the season due to fraying in his left Achilles tendon.[8] The surgery was successful to repair the Achilles, but the rehab was not complete until late in the 2010 year, causing many of his future issues.[how?]
Reimold started the season with the Baltimore Orioles as the starting left fielder. After a slow start in his first 83 at-bats, Reimold was demoted back to Norfolk on May 12, 2010, where the coaching staff was retooling him to play first base. Since that time, the Orioles released their starting first baseman Garrett Atkins, which may allow Reimold to rejoin the Orioles after the All-Star Break.[9]
Nolan had a successful 2011 campaign with most of his playing time in left field after Luke Scott tore his labrum and Félix Pie was sent down to the minor leagues. In the season finale against the visiting Boston Red Sox, he tied the game on an RBI double and crossed the plate for the game-winning run. The loss, coupled with the walk-off win by the Tampa Bay Rays minutes later, eliminated the Red Sox from playoff contention.
Reimold started the 2012 season strong playing in left field, hitting .313 with five home runs and 10 RBIs in his first 16 games, but was plagued by injuries, including a herniated cervical disk,[10] that put him on the disabled list after April 30. He was moved to the 60-day disabled list on June 12. On June 22, it was announced Reimold would undergo surgery to repair the disk in his neck, which ended his season.[11]
Reimold struggled in 2013, dealing with more injuries and batting .195 with five home runs and 12 RBIs in 40 games. In order to fix the procedure performed the previous June, he was once again forced to undergo season-ending corrective surgery after limited playing time.[12]
After the season, Reimold signed a one-year contract with the Orioles, promising him just over $1 million for the 2014 season while avoiding arbitration.[13]
Reimold was designated for assignment by the Orioles on July 1, 2014. He was claimed off waivers by the Toronto Blue Jays on July 6.[14] After 4 games played with the Blue Jays, in which he batted .333 with 3 RBI, Reimold was placed on the 15-day DL with a left calf strain on July 12.[15] On July 31, 2014, Reimold went 2 for 4 including 2 home runs against the Houston Astros to lead the Blue Jays to a 6-5 victory.[16] He was designated for assignment on August 26 when Kevin Pillar was recalled.[17] On August 28, Reimold was claimed off waivers by the Arizona Diamondbacks.[18]
On February 3, 2015, Reimold signed a minor league contract with the Baltimore Orioles that included an invitation to spring training. [19] In April 2015, Reimold was assigned to AAA Norfolk.[20] In June, the Orioles recalled Reimold from AAA Norfolk.[21] He was designated for assignment on August 24,[22] and brought back up on September 6.[23]
At the All-Star break, Reimold hit .268 (33-for-123) in 57 games with 4 homers and 11 RBIs.
On July 24, Reimold hit his third career walk off home run off of Cleveland Indians pitcher Cody Allen to defeat the Indians 5-3.[24]
Personal life[edit]
Nolan married the former Jennifer Corace and they have six children. Reimold has an older brother, John, who played for the Bowling Green State University men's basketball team,[2] and currently plays professionally in Luxembourg. Reimold's younger brother, Shamus, is studying to be an Ophthalmologist. He currently attends Lake Erie College of Osteopathic Medicine in Erie, Pennsylvania. He also has a younger sister, Dierdre Reimold, who is currently a model.
- ^ Mid-American Conference Baseball Tournament 2005 Notes – Bowling Green State University Athletics.
- ^ a b c d e "Bowling Green Bio". bgsufalcons.cstv.com. Retrieved 2008-12-22. Cite error: Invalid
<ref>tag; name "Bio_at_Bowling_Green_website" defined multiple times with different content (see the help page).
- ^ a b "Bowling Green State University Baseball Alumni". The Baseball Cube. Retrieved 2008-12-22.
- ^ "Nolan Reimold Awards". The Baseball Cube. Retrieved 2008-12-22.
- ^ a b c "Nolan Reimold". minor league baseball. Retrieved 2009-01-08. Cite error: Invalid
<ref>tag; name "Minor_league_baseball_profile" defined multiple times with different content (see the help page).
- ^ Baseball America (2009). Baseball America Prospect Handbook 2009. Durham, North Carolina: Baseball America Inc. p. 52. Check date values in:
- ^ Zrebiec, Jeff (July 3, 2009). "Reimold named top AL rookie for June". The Baltimore Sun. Retrieved 2009-07-05.
- ^ Article written by Jeff Zrebiec
- ^ http://masnsports.com/school_of_roch/2010/05/trembley-explains-reimold-at-first.html?utm_source=twitterfeed&utm_medium=twitter
- ^ Fenton, Justin; Cohn, Meredith (14 April 2015). "Orioles' Reimold sues Johns Hopkins over medical care". The Baltimore Sun. Connolly, Dan (contributor).
- ^ Ghiroli, Brittany. "Reimold to have season-ending surgery on neck," MLB.com, Friday, June 22, 2012.
- ^ Ghiroli, Brittany. "Reimold set for second straight season-ending surgery," MLB.com, Friday, July 19, 2013.
- ^ "Nolan Reimold to re-sign with Orioles". ESPN.com. Associated Press. January 14, 2013. Retrieved August 29, 2014.
- ^ Wilmoth, Charlie (July 6, 2014). "Blue Jays Designate Brad Glenn For Assignment". mlbtraderumors.com. Retrieved July 6, 2014.
- ^ "Jays send Reimold to 15-day DL, call up Gose". Sportsnet. July 12, 2014. Retrieved July 12, 2014.
- ^ Chisholm, Gregor (July 31, 2014). "Blue Jays turn four homers into sixth straight win". MLB.com. Retrieved July 31, 2014.
- ^ Lott, John (August 26, 2014). "Toronto Blue Jays call up Kevin Pillar, designate Nolan Reimold for assignment days before rosters expand". sports.nationalpost.com. Retrieved August 26, 2014.
- ^ "D-backs claim OF Reimold off waivers". ESPN.com. Associated Press. August 28, 2014. Retrieved August 29, 2014.
- ^ Ghiroli, Brittany (February 3, 2015). "Gonzalez deal among flurry of Orioles moves". MLB.com. Retrieved February 7, 2015.
- ^ Wise, Brandon. "Orioles reassign outfielder Nolan Reimold to minor leagues". CBSSports.com. CBS.
- ^ "Orioles calling up Nolan Reimold before Red Sox series". Camden Chat. Retrieved July 21, 2015.
- ^ "Orioles make flurry of roster moves before Royals series". ESPN.com. Associated Press. August 24, 2015. Retrieved August 25, 2015.
- ^ d'Oliveira, Sean (September 6, 2015). "Orioles promote Nolan Reimold for Sunday's game". CBSsports.com. Retrieved September 6, 2015.
- ^ http://www.cleveland.com/tribe/index.ssf/2016/07/cleveland_indians_baltimore_or_32.html
External links[edit]
- Career statistics and player information from MLB, or ESPN, or Baseball-Reference, or Fangraphs, or The Baseball Cube, or Baseball-Reference (Minors)
- 1983 births
- Living people
- Baseball players from Pennsylvania
- Major League Baseball outfielders
- People from Greenville, Pennsylvania
- Baltimore Orioles players
- Toronto Blue Jays players
- Arizona Diamondbacks players
- Bowling Green Falcons baseball players
- Frederick Keys players
- Grand Canyon Rafters players
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- Bowie Baysox players
- Gulf Coast Orioles players
- Phoenix Desert Dogs players
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- Norfolk Tides players
- All-Star Futures Game players