text:
Ictal and Interictal Inflammatory Markers in Migraine
This study has been completed.
Johns Hopkins University
University of Toledo Health Science Campus
The Cleveland Clinic
Information provided by (Responsible Party):
Drs Barbara Peterlin, Johns Hopkins University
ClinicalTrials.gov Identifier:
First received: June 3, 2010
Last updated: October 22, 2014
Last verified: August 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to evaluate blood levels of several proteins that may be altered in the inflammation associated with migraine headaches. These blood levels will be evaluated in individuals during an acute migraine attack and compared to their levels when pain free. The investigators study hypothesis is that the pro inflammatory proteins in the blood will be greater than the levels of these proteins when evaluated during a pain free period.
Drug: sumatriptan/naproxen sodium
Drug: Placebo
Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
|Official Title:
|Ictal and Interictal Inflammatory Markers in Migraine
Resource links provided by NLM:
MedlinePlus related topics: Headache Migraine
Drug Information available for: Naproxen Naproxen sodium Sumatriptan Sumatriptan succinateU.S. FDA Resources
Further study details as provided by Johns Hopkins University:
Primary Outcome Measures:
- Blood levels of proteins will be evaluated at baseline when subjects are pain-free and then repeated during an acute attack, both prior to drug administration and then at 30 minutes, 1 hour and 2 hours after acute treatment. [ Time Frame: one year ] [ Designated as safety issue: No ]
|Study Start Date:
|September 2009
|Study Completion Date:
|June 2013
|Primary Completion Date:
|June 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Active Comparator: Treximet
Drug: sumatriptan/naproxen sodium
One tablet of sumatriptan 85 mg and naproxen sodium 500 mg will be given upon subject presentation with an acute migraine attack and after blood levels have been drawn.
Other Name: The brand name of sumatriptan/naproxen sodium is Treximet.
|Placebo Comparator: Sugar Pill
Drug: Placebo
One tablet of a sugar pill will be given upon subject presentation with an acute migraine attack and after blood levels have been drawn.
|Ages Eligible for Study:
|18 Years to 55 Years (Adult)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age greater than 18 years of age, migraine
Exclusion Criteria:
- Pregnant or breast-feeding women, presence of cardiovascular or cerebrovascular disorders as well as any known inflammatory, infectious, metabolic, thyroid, renal, cardiovascular or gastrointestinal diseases
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01138150
Please refer to this study by its ClinicalTrials.gov identifier: NCT01138150
|United States, Maryland
|The Johns Hopkins Bayview Headache Center
|Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
University of Toledo Health Science Campus
The Cleveland Clinic
|Principal Investigator:
|Barbara L Peterlin, DO
|The Johns Hopkins University
More Information
Keywords provided by Johns Hopkins University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 26, 2016
|Responsible Party:
|Drs Barbara Peterlin, Director, The Johns Hopkins Bayview Headache Research, Johns Hopkins University
|ClinicalTrials.gov Identifier:
|NCT01138150 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|June 3, 2010
|Last Updated:
|October 22, 2014
|Health Authority:
|United States: Institutional Review Board
Keywords provided by Johns Hopkins University:
migraine, headache, sumatriptan, naproxen sodium
Additional relevant MeSH terms:
Migraine Disorders
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Gout Suppressants
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Vasoconstrictor Agents
Serotonin 5-HT1 Receptor Agonists
Serotonin Receptor Agonists
Serotonin Agents
Neurotransmitter Agents
ClinicalTrials.gov processed this record on September 26, 2016


text: The Feed Channel provides Triggers and Actions for working with RSS and Atom web feeds. A web feed (or news feed) is a data format used for providing users with frequently updated content. Content distributors syndicate a web feed, thereby allowing users to subscribe to it. Connect Popular Feed Recipes Email me '10 Things To Know This Morning' by curtisjake 35k 35043 adds 106 106 favorites Email me a famous quote every day by brainyquote 27k 27935 adds 454 454 favorites Get a Lifehacker Deals newsletter sent to your email by gyroscope352 25k 25952 adds 468 468 favorites Get alerted to new flight deals from 'The Flight Deal' by jamisonross 16 16 adds 0 0 favorites Email me when a new startup is featured on @betalist by chrisboutet 16k 16017 adds 336 336 favorites NOAA Severe Weather Notification by jamisonross 33 33 adds 2 2 favorites Browse more Recipes The Feed Channel goes well with Email IF Notifications Triggers New feed item This Trigger fires every time a new item is added to the feed you specify. Trigger fields Feed URL New feed item matches This Trigger fires every time a new item in the feed you specify contains a particular keyword or simple phrase. Trigger fields Keyword or simple phrase Feed URL Actions There are currently no Actions for this Channel.

subset: commoncrawl


text:
Posts Tagged 'Showcases'.
We are pleased to present below all posts tagged with 'Showcases'.
We use ad-blockers as well, you know. We gotta keep those servers running though. Did you know that we publish useful books and run friendly conferences — crafted for pros like yourself? E.g. upcoming SmashingConf Barcelona, dedicated to smart front-end techniques and design patterns.
We are pleased to present below all posts tagged with 'Showcases'.
Let's put it straight - simplicity is more complex than you probably think it is. To design a web-site in user-friendly tones, presenting all information and removing unnecessary details isn't easy. In fact, many designers don't manage to find the right mix between details and their presentation on the screen, which usually results in an information overkill and/or decreased usability. However, some designers do manage to find the right balance and create usable, elegant and clean web-sites with simple layouts.
We've selected some of them. 49 simple, clean, sometimes even minimalistic designs, which all stick closely to one single principle - Keep It Simple, Stupid!. You can also download the whole KISS-gallery in PDF (7,2 Mb) - the document includes high-resolution screenshots and the list of all showcased web-sites. Please do not copy the list, but refer to it with a link.
Update: We've been buried as inaccurate/spam on Digg.com. If you don't think that this post is inaccuarate and you don't see any spam here, keep digging us and let us know your opinion in the comments.
Recently we've suggested few start points one could start learning simplicity from. If you are looking for inspiration, you'd probably like to check
Navigation menus have to be intuitive, precise and easy-to-use. One simple, basic principle, which is common for all kinds of nav bars you would ever want to use for your projects. In fact, navigation menu is probably the most important element in web design: after all, it is being used more often than any other element on a given page. Therefore it's important to make sure that your visitors will find they way around the site structure - however complex the latter might be.
So how do designers cope with a challenging task to create an attractive and usable menu? Which results can be achieved? OK, that's a tough one. Let's take a look around.
Below you'll find 53 beautiful and user-friendly Navigation Menus and solutions web-designers came up with using basic CSS styling.
PS: Over the last few months we've reviewed CSS-Based Techniques, CSS-Based Forms and CSS-Based Tables and CSS-Based Footers (yes, some of these techniques use not only CSS, but also JavaScript and PHP). You'll find even more CSS-related articles in our CSS Section.Read more...
Logotypes stand for Corporate Identity. The better a logo is designed, the greater is the probability that your potential clients will remember your CI and get back to you once your service is needed. Consequence: designers have to be creative and put many efforts in designing beautiful, unique and catchy logos. And the results they come out with are sometimes stunning and spectacular. Both in graphic design and web design.
This isn't just another collection of logotypes. These are 58 creative logos you can inspire yourself from. Nevermind how different the logos are - they show the current trend in modern logo design. The logos we've selected below have been created and optimized for Web.Read more...
Sometimes it's just amazing to see, which level of usability, legibility and visual appeal can be achieved using some basic design techniques. In fact, some talanted web-developers manage to deliver powerful, functional and gorgeous web-design in "look-and-feel"-style, which is easy to use and nice to see.
Recently we've listed 50 Beautiful CSS-based web-design of 2006 and chosen some of the most beautiful and inspiring dark web-designs. Now we've selected 45 more fresh, clean and impressive designs. Let's take a look.Read more...
Dark designs can be really stunning. I mean, really. In Web 2.0 designers try to do their best to impress their visitors and in many cases they definitely succeed in doing so.
As a second (out of five) part of our 50 Beautiful CSS-Based Web-Designs in 2006 collection we'd like to present some stunning, but rather unknown dark designs, which you really should have seen if your aim is to develop web-sites in the modern "Look & Feel"-style. Important: if you like this article, please let us know digging it and/or bookmarking it. Otherwise we'll break this series of articles and will offer you another content.Read more...
2006 was rich on creative, beautiful and unusual design concepts. We've seen a lot of whitespace, many examples of readable and usable text-design, badges, stars, rounded corners, shapes, gradients, mirror and 3D-effects - just name it. Let's take a close look at some of the most beautiful designs we've seen in 2006. Some gorgeous designs are missing? Let us know - comment on this article!Read more...


text:
On Thursday, Colorado-based Proterra Inc., a manufacturer of drive and energy storage systems for buses and trucks, announced that it will locate its new manufacturing and innovation center in Greenville, S.C., where the company will hire more than 1,000 employees to design and manufacture its line of clean transportation solutions.
Proterra's plant will be located within the Clemson University International Center for Automotive Research (CU-ICAR) campus, enabling Proterra to form a close partnership with CU-ICAR to accelerate technology innovation and commercialization of its all-electric and battery-dominant hybrid drive solutions.
Proterra's Greenville manufacturing and research and development center will open in 2011 and be housed in a newly constructed 250,000 square foot building on the CU-ICAR campus. The new facility is in addition to Proterra's headquarters in Golden, Colo.
The plant will be home to the manufacturing and development initiatives of the company's clean commercial transportation solutions, which include all-electric and battery-dominant hybrid transit, school and commercial buses, parcel delivery vehicles and other class 4-8 trucks. The company plans to hire more than 1,000 local employees in the next four years.
Proterra's Greenville facility will begin with a groundbreaking in the spring of 2010, and be operational in 2011. Hiring for the facility will focus on manufacturing, supply chain, product management and operations roles.
This year's event definitely had something for everyone, including the most buses on one North American show floor, a closer look at issues set to impact transit maintenance professionals, an up-to-date look at electric buses and a the BusCon Connect hosted buyers program.
This BRT program, which is part of the voter-approved Levy to Move Seattle, will provide high-quality transit throughout some of the densest areas of Seattle.
The purchase furthers Hometown Trolley's overall strategic business model to become the leading trackless trolley bus manufacturer in the North American transit industry.
The system will be introduced on Volvo's European city bus fleet in 2017.
The company's ST 1064 hydraulic mobile column lift has a capacity of 14,000 lbs. per column, or 56,000 lbs. for a set of four.
Receive latest news and stories
The Car and truck fleet and leasing management magazine
managing 10-50 company vehicles
Executive vehicle management
managing public sector vehicles & equipment
The number 1 resource for vocational truck fleets
Serving school transportation professionals in the U.S. and Canada
Global Resource For Limousine and Bus Transportation


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Forgot Password? | Not a User? Sign up
On consecutive weekends, Elizabethtown has played host to major events that celebrate youthful athletic accomplishments.
If you currently subscribe or have subscribed in the past to the The News Enterprise, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
|ZIP Code:


text:
Tuesday marks 150 years since President Abraham Lincoln delivered the Gettysburg Address.
Events mark anniversary of Gettysburg AddressUPDATED 11:46 AM EST Nov 19, 2013
Slideshow Central
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


text:
Ce texte a été automatiquement traduit. Voir textes originaux
Entrez dans la Vieille Ville 1873 House Inn and Restaurant et vous serez époustouflé par son importance historique et l'héritage distinctive à St. Augustine. Couplez l'auberge avec ses charmants nouveaux propriétaires, Juan et Christopher, et vous avez une histoire de classe mondiale de romance et d'aventure! Old City House, seulement Historic Inn St. Augustine avec un restaurant à service complet de son architecture néo colonial espagnol. L'caractéristiques restaurant haut de gamme à manger dans une ambiance chaleureuse et conviviale. Notre menu propose une cuisine internationale avec flayfor international. Juan et Christopher vous invitons à visiter la Vieille Ville House Inn où hospitalité à l'ancienne commence dans la plus ancienne ville d'Amérique.
4,4 sur août 19, 2016
We loved our stay at Old City House Inn & Restaurant! We were moved to a bigger room, which was excellent. The bathrooms in the rooms are a bit aged, but that was really our only negative (and they weren't even that bad). The breakfast is superb and the wine and cheese should not be missed. We basically walked everywhere (except to the beach of course...that was about a 15 min drive). Perfect location. The hosts were wonderful! Highly recommend this place!
4,8 sur août 15, 2016
Our stay at the Old City House Inn was wonderful. It is a place where you must stay especially if it is your first time visiting St. Augustine. (It was ours). My husband and I went for our four year anniversary and we booked the Flagler Room for three days. The room was really comfortable and it really made us feel at home. The hospitality was warm, welcoming, and ready to be at our service. The breakfast was absolutely delicious, the plates were beautifully decorated which showed that our meal was made with much care for our taste and creativity for our delight. They also provided complimentary bicycles that me and my husband took the pleasure of using to ride through the old streets of St. Augustine. One evening we were invited to a complimentary wine and cheese tasting which was really nice because the bar tender was so nice to suggest the go-to places of St. Augustine. The whole experience was just amazing, you really feel like you step back in time when you stay at the Old City House Inn because it is literally in the heart of St. Augustine. We hope to visit again soon!
5 sur août 11, 2016
We were here about 5 years ago and loved it. So when we were passing through Saint Augustine this week, Old City House Inn is the only place we considered staying. Normally we look for Hilton Garden Inn or Double Tree. Old City House is right there and BETTER. FOOD IS SUPERB! Paul and Cara
4,0 sur juillet 03, 2016
The service staff were absolutely amazing!! They helped us with a couple of requests and were totally outstanding about it! The breakfast waiter was also awesome!!
4,6 sur juin 27, 2016
repeat customer.....great B&B
5 sur juin 25, 2016
I brought my wife to the Inn for her birthday, she loved every moment we spent there. The only downside was the morning of our check out. There was construction literally right outside our window. But the food and hospitality and personal attention we got from the owners was unparalleled. I definately recommend this place
5 sur juin 24, 2016
We just keep going back. The owners are wonderful people and are improving the Inn more and more. The food is outrageously fantastic. We enjoyed our breakfast and we also had dinner there. Food is always served with a smile and is always made with love. I would recommend this place as it is also very close to the downtown area and the beautiful park. Can't wait to go back and enjoy the calming atmosphere after walking around all day and just enjoy a glass of wine on the patio or at the tables in the downstairs garden. Thank you Old City House Inn for a wonderful; birthday celebration and vacation. Did I mention that the beds are the best to sleep on and the rooms are so clean . What a perfect getaway...........
5 sur juin 16, 2016
We stayed in the Ammidown Room, it was very nice. People are very friendly and helpful. I highly recomend this place. Breakfast is just amazing
3,8 sur juin 15, 2016
My husband and I chose to stay at the Old City House Inn & Restaurant to celebrate our one year wedding anniversary. The B&B is in a great location in walking distance to everywhere we wanted to go. We stayed in the Alcazar room and we absolutely loved the big, comfortable bed. Although we did not try the onsite dining for lunch or dinner, we enjoyed the two-course breakfast complete with French toast, an omelette, potatoes, and breakfast meat. The price is more than we typically spend on accommodations for one night, but we enjoyed our experience and will return in the future if the opportunity presents itself.
4,0 sur juin 08, 2016
Totally enjoyed the "old city" experience while taking in the sites and sounds of the 'old world' . . .
The Ammidown Room is located on our second floor. It has a queen-size bed, cable TV, an en suite bathroom with shower, a large stained glass window, cathedral ceilings, and a private entrance via a covered hallway.
The Alcazar Room is located on our second floor and has a beautiful view of the Lightner Museum gardens and Flagler College. It has a king size mahogony bed, cable TV, an en suite bathroom with shower, cathedral ceilings, and a private entrance via its own staircase. This staircase can also be made accessible to our Flagler Room providing a two bedroom suite if desired.
Our Lightner Room is located on our second floor and has its own private balcony that looks out over the Lightner Museum, the Museum Gardens, and Flagler College. The room has a queen size four-poster, cast-iron bed, a large double window looking toward the Lightner Museum, cable TV, an en suite bathroom with shower, cathedral ceilings, and a private entrance via a covered hallway.
Our Cordova Room is located off a large, pleasantly shaded deck on our second floor. It has a KING-size, hand-carved bed, chaise-lounge, cable TV, an en suite bathroom with shower and bath, and a private entrance off the deck. Windows in the room look north towards Flagler College, the gardens of the Lightner Museum, and the Casa Monica Hotel and south towards Palm Row, a quaint residential subdivision built in the late 1800s.
The Flagler Room is located on our second floor and is one of our larger rooms. In addition to a queen-size, hand carved, four poster bed, the room has a small living area with a (queen size) day bed and coffee table. The room also has cable TV, an en suite bathroom with shower and bath, and a private entrance via a covered hallway. A second entrance way allows access to our rear staircase and our Alcazar Room providing a two bedroom suite if desired.
Our Augustin Room is located on the first floor and has a private entrance located adjacent to the Inn's Office and Inn Keeper's Residence. This large room has hardwood floors, a KING-size bed, cable TV and VCR, and an en suite bathroom with Jacuzzi bath and shower. A beautiful stained glass door separates the bath area and bedroom. The room also has a small sitting area
The St. George Room is our most popular room and is located on the second floor. The room has a large sunburst window looking south towards Palm Row, a quaint residential subdivision built in the late 1800s. The room has a large Jacuzzi tub separated from the main bedroom area by plantation shutters. The room also has a KING size bed, cable TV and , and an en suite bathroom with walk -in shower.
Environs de Waterfront, Centre ville
Jacksonville, FL (JAX) 55 miles
Prenez la sortie 95 (Route 16) sur la I-95. Voyage à l'est d'env. 6 miles. Après RR croisement, tourner à droite sur US-1 sud. Au 3ème feu à gauche sur la rue King. Au 3ème feu tourner à droite sur Cordoue. Nous sommes le 2e bâtiment sur la gauche. Le parking est juste devant le bâtiment sur la gauche.
Antiquaires , Aquarium , Galeries d'art, Plage, Lieu de concert, Dîner gastronomique, Sites historiques, Concerts, Cinéma , Musée, Parcs nationaux/régionaux, Zone naturelle, Océan, Les rues pavées et les sites historiques à gogo., Boutiques, Théâtre, Zone de pic-nic, Services religieux, Rivière, Ruines, Entreprise vinicole, Zoo
Bed and Breakfast, Historic Inn
Panier d'agréments, Jeux de société, Ordinateur, Salles de conférence, Copieur, Bureau, Fax, Cheminée, Téléphone, Magnétoscope, Machine à laver/sèche-linge, Equipé pour les mariages, Espace bar
Climatisation, Réveil, Lecteur CD, Ventilateurs de plafond, Cafetière/Bouilloire, Sèche-cheveux, Internet, Planche à repasser, Entrée indépendante, Radio, Réception chaînes satellite, TV, Wi-Fi, Internet par câble
Vélos, Observation d'oiseau, Base nautique, Canoë, Pêche, Golf, Sentiers de randonnée , Canoë-Kayak, Wave Rider et location de bateaux, Voile, Shopping, Excursion, Natation, Terrain de tennis, Location de raquettes tennis, Sports d'eau
Juan Solano
Afrikaans, Anglais, Allemand, Espagnol
James et Ilse bon voyage et rencontre des gens, danse, dîner, exploration, tennis, golf et un peu de surf !
servi seulement pour les clients. Petit-déjeuner de deux cours
Equilibré , Régime particulier , Végétarien sans gluten
Croûte de fines herbes bar chilien
Herb croûte bar chilien rôti avec pommes de terre à l'aneth sauce citronnelle carré d'agneau désossé


text:
4info.net is a mobile search service (SMS, Web, Mobile Web) that we've blogged about a lot in 2005 and I continue to be impressed with. I also use it on a very regular basis. The San Francisco company is ending the year with even more search tools for the mobile web user.
The following links will take you to pages with more info about the service and how to access it. A mobile emulator also allows you to demo or use the service via a regular web browser.
+ Package Tracking
Track FedEx or UPS packages.
+ News Headlines
Enter a keyword, city name or Zip Code.
+ Fantast Sports Alerts
"Set up text message alerts whenever your fantasy player scores, turns the ball over, or at the end of each period. Currently available for NFL, NHL, NBA." Logon to My4info.net for more info.
+ Enhanced Sports, Rankings and Standings:
"We've also added the ability to query for college and professional sports rankings and/or standings. Try texting "ncaab rankings" or "nba pacific standings" to 44636 find out how your favorite teams are doing."
Here's A List of a Few Key 4info.net Postings from 2005
+ Mobile Search: 4Info.net Has Plans to Release Client Software
+ Accessing Flight Info on the Web
+ 4INFO Releases Directory of Mobile Web Sites
This small but growing directory was a welcome addition this year! I hope it stays as dynamic as the mobile web and continues to be updated with new services.
Related reading
How mobile is transforming the restaurant order and delivery business
To date the leaders of restaurant takeaway and delivery have prospered, largely, on an open approach, that allows customers to choose between mobile web and apps.
Adblock Plus gets into the ad business with launch of RTB platform
Adblock Plus, one of the most popular ad blocking add-ons for browsers, is getting into the ad business.
Google announces two mobile-first product innovations at DMEXCO
Sridhar Ramaswamy, Google's SVP of Ads & Commerce made two major product announcements this morning at DMEXCO 2016.
Which is the king of mobile: China or US? Where is the biggest opportunity?
When the enormity of the population is taken into account, how does China compare with the US on mobile?