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Crowne Plaza Hamburg - City Alster
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- Suites
- Minbar in room
- Restaurant
- High-speed internet in room (free)
- Wireless internet connection in room (free)
- Wireless internet connection in public areas
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Historical Traveler Reviews Crowne Plaza Hamburg - City Alster
Posizione e rapporto qualità/prezzo ottimi
Sono stato in una camera Comfort in due occasioni diverse nel novembre 2006. L'albergo si trova a circa 2 Km dalla stazione ferroviaria principale ed � facilmente accessibile prendendo l'autobus No. 6 che passa, ogni 10 minuti circa, appena usciti dalla stazione fino a quasi davanti l'albergo. A due passi dall'albergo (a circa dieci minuti a piedi andando lentamente) ci sono un sacco di ristoranti e caff�.
Io sono rimasto contentissimo di quest'albergo, la camera era di dimensioni ragionevoli per il metro europeo, immacolata, ben attrezzata e aveva un letto molto comodo. Il bagno era moderno e moderatamente grande (di nuovo, secondo il metro europeo).
Il personale era efficiente e premuroso. Il taxi dall'aeroporto vi coster� €20 e il viaggio durer� 20 minuti (di pi� durante l'ora di punta).
Excelente hotel
Excelente hotel en una buena zona,muy tranquila,pero no lejos del centro de la ciudad.Nos alojamos un par de noches y la unica critica mala que puedo hacer es que la habitacion no era muy garnde pero si confortable,lo mismo que el ba�o.Habia leido que te daban albornoz y no fue asi,pero aun asi,disfrutamos mucho de la estancia.El desayuno genial y la piscina lo mismo.La relacion calidad precio muy bien.Lo recomiendo
Good hotel
This is a good hotel. Bed was comfortable, breakfast was good, the room was clean and the price was reasonable. No complaints. It's in a pretty good location, you can walk to the lake. It's not too far to walk to the center, but you are not right in the middle of the shopping district, so you may want to take a taxi once in a while. The taxis aren't too expensive in Hamburg though.
They rent bikes also, which is nice, although for some reason they don't maintain them all - around half of the bikes were out of service when we wanted them, so we had to wait for some others to come back.
There is are some good restaurants within walking distance - we especially enjoyed Cox, Lange Reihe 68.
Das Hotel liegt ein paar Gehminuten vom Hauptbahnhof entfernt in einem ruhigen Quartier, eine Strassenecke von der Alster entfernt (grossartige M�glichkeit f�r Jogging!). Unser Zimmer war gut, so wie viele Hotelzimmer besserer Ketten eben gut sind. Besonders lobenswert ist das �usserst freundliche Personal, insbesondere in der Lounge, von der aus man einen sch�nen Ausblick auf die Skyline hat. Ebenfalls zu empfehlen ist ein Besuch im Swimming Pool. Wir haben den Aufenthalt voll genossen und k�nnen das Hotel w�rmstens empfehlen.
Really great hotel!
This hotel was really good. Typical of the group. I stayed one night ... would have loved to have stayed more. The bar and restaurant were both very good and breakfast was well varied. All staff were courteous and very attentive. The room was a fair size and had a proper desk and chair. I did think parking was a bit expensive.
Couldn`t faullt it at all
Nice location - lots of great bars and restaurants within easy walking distance.
Staff exceptionally friendly - and some English staff as well.
Breakfast was an enormous choice, one of the best I`ve ever seen.
The hotel sells the Hamburg Card which is very good value giving free transport and discounts on attractions. For our party of 4 adults it cost about 11 euros each for 4 days.
The room was typically `business` but was exceptionally clean and had blackout curtains.
I would definitely stay there again.
Nice Hotel for Tourism & Business
Very nice hotels in not a far distance to the center of Hamburg. Seven floors with a very nice atrium in the middle with a glass roof on top.
Rooms are very good for the 4-star-standard of the hotel, nice bathroom, most rooms have a desk for some work.
Price are very okay (we paid 89 € for one night incl. breakfast), car parking is 18 € for 24 hours (it is also possible to park right on the street, but there's hard to find some space). Breakfast was very delicious, really worth it's money. People in the hotel very helpful, gave us some informations about Hamburg.
So, all in all very recomendable High-Class-Hotel with good prices right in the middle of the town (just takes 4 stations by bus to the main shopping street and harbour, Express-Line-Station just 50 meters away).
Great hotel, would stay there again
I stayed with my sister at the Cowne Plaza when we went to Hamburg for a long weekend. We paid 99 € including breakfast. The room was really nice and new, the bathroom was excellent. The breakfast was super, really worth paying for. The staff was friendly, and spoke good english.
The location was easy to get to, we took the airport express bus (110) to Ohlsdorf, and then the S1 train, changed to the U2 at Barmbek, and got off at Uhlandstrasse.
The main railwaystation and the beginning of the shoppingarea was 15 minutes away (walking).
Loved the hotel
We were a group of 4 women visiting Hamburg in February 2005, and were staying at the Crowne Plaza, sharing 2 double-rooms.
Convenient location, nicely renovated rooms. Very helpful stuff. Delicious breakfast buffet.
I can recommend it, it's worth the money.
Excellent interior
Just a normal hotel form the outside, but very nicely finished inside. The rooms are just like every other 'business' hotel you ever stayed in but a recent refurbishment means that the rooms are immaculate. Leather chair at the desk, mini hi-fi, some really nice touches. Of course, giant German pillows too - you have to love them. There is a small pool, no good for proper swimming but relaxing decor. Staff helpful and indulged my rubbish attempts at German.
TripAdvisor Reviews Crowne Plaza Hamburg - City Alster
Travel Blogs from Hamburg
Back in the Air
... screaming, "I'm the aerialist, the one swinging at the top of this silk and I love it! Love my job, love my life, love, love, hippie talk, peace, love, love. It's my dream! My dream accomplished; finally I can stop wistfully staring at the rows and rows of circus DVDs I've accumulated since the age of ten..." except that the words actually being vocalised are, "Oh, I'm part of the ensemble, I do this and that."
It's not to beat down the rest of the cast; nothing wrong ...
Our last supper with Mali :(
Yep, as suspected it was a sleep in for Lyndon this morning (11:00am!!!) while I on the other hand was fresh as a daisy. So although we had planned to go into town to do some more sightseeing we spent pretty much all day hanging around the house. Poor Annette will be glad to see the back of us tomorrow.
Once Mali was home from school we headed across town for a family trip to Circus Roncalli (not the animal kind, well except for some horses). We had really great ...
Germany vs Australia? Nah, everyone for themselves
Another sleep in for us again, so another morning having a late breakfast with Annette. We eventually got ourselves organised enough to leave the house so we headed into town on the train to visit Miniature World. I must admit I really didn't think that I would enjoy it but was happy to go as I knew the kids would find it fun …. but it was great. The first section showed the same town through different eras, which was interesting to see. Then there was a section on how a town ...
Day 36: Hamburg
... city. Hamburg has the second largest port in Europe, which I find odd because it's a hell of a way from the ocean. But needless to say it's big, and Miniature Wonderland was located in a warehouse in the old port at the edge of the city centre. It took about 25 minutes to get there, and mercifully the rain held off, which was a surprise given how grey it was. I knew I'd gotten where I needed to be given there were a heap of fathers and their young sons congregating in the ...
Hallo Deutschland!
... and photo) in Atlanta, together with John Snyder. I have been looking forward to this meeting to hear from him about BCD EMEA and his point of view about the challenges of the region: the difference in the legislation, language and mentality. Furthermore, he talked about the industry changes in technology, GDS's and behavior. As a remark, he talked about the need of change on the way ...


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The White Mists of Power
by Kristine Kathryn Rusch
- #4282 in Science Fiction & Fantasy, Fantasy, Epic Fantasy
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An innocent excited boy, a prince and heir, takes his first journey to the city. The streets teem with merchants in velvet robes, magicians, half-mad preachers, with life and color, poverty and noise. He doesn't want to miss any of it.
But this marks the last journey in his life as a prince. Soon he will be abandoned and declared dead. Soon he will be utterly alone, faced only with survival and what will become the driving force of his life: the quest to recover his stolen inheritance, his usurped throne, his home.
A story of cities and palaces, of power-hungry lords and ladies scheming inside a magically threatened land. Intricate and compelling, The White Mists of Power is the debut novel of an author who has gone on to have a seismic impact on the science fiction and fantasy field.
"A traditional high fantasy novel…Rusch has added elements that make it original and unique. The story is strong, the magic subtle and mysterious."
"A prince reclaiming his lost kingdom is…a compelling story. Rusch provides some unusual twists. Every bit as good as her fine short fiction."
—Science Fiction Chronicle
"A thrilling read."
"Moves at a whirlwind pace through political intrigue…A remarkable amount of plot as well as beguiling characters."
—Publisher's Weekly
USA Today bestselling author Kristine Kathryn Rusch writes in almost every genre. Generally, she uses her real name (Rusch) for most of her writing. Under that name, she publishes bestselling science fiction and fantasy, award-winning mysteries, acclaimed mainstream fiction, controversial nonfiction, and the occasional romance. Her novels have made bestseller lists around the world and her short fiction has appeared in eighteen best of the year collections. She has won more than twenty-five awards for her fiction, including the Hugo, Le Prix Imaginales, the Asimov's Readers Choice award, and the Ellery Queen Mystery Magazine Readers Choice Award.
To keep up with everything she does, go to kriswrites.com. To track her many pen names and series, see their individual websites (krisnelscott.com, kristinegrayson.com, krisdelake.com, retrievalartist.com, divingintothewreck.com, fictionriver.com). She lives and occasionally sleeps in Oregon.
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by Kristine Kathryn Rusch
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by on September 30, 2016
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- WMG Publishing Incorporated, December 2012
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Quality Inn & Suites Indio I-10, Indio
- Free hot/cold buffet breakfast, free WiFi, and free parking
Main amenities
- 125 guestrooms
- Outdoor pool
- Fitness center
- 24-hour business center
- Air conditioning
- Daily housekeeping
- Front desk safe
- ATM/banking services
- Self-serve laundry
- Free newspapers in the lobby
- Luggage storage
For families
- Free cribs/infant beds
- Refrigerator
- Connecting/adjoining rooms available
- Private bathroom
- Premium TV channels
- Free toiletries
What's around
- Davis Sports Complex (2.1 mi / 3.4 km)
- Riverside County Fairgrounds (2.3 mi / 3.8 km)
- Indio's Municipal Golf Course (2.4 mi / 3.9 km)
- Indio Towne Center (2.5 mi / 4 km)
- Coachella Valley History Museum (2.5 mi / 4 km)
Quality Inn & Suites Indio I-10, Indio
Hotel Info: 020 3027 9803from £65
- Standard Room, 1 King Bed
- Standard Room, 2 Queen Beds
- Suite, 1 King Bed, Non Smoking
- Standard Room, 1 King Bed, Non Smoking
- Standard Room, 2 Queen Beds, Non Smoking
Also popular with travellers from the UK
At a glance
Key facts
Hotel size
- This hotel has 125 rooms
- This hotel is arranged over 2 floors
- Check-in time 3 PM-7 AM
- Check-out time is noon
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (18 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets not allowed
- Pets allowed *
- Up to 30 lb
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
- Free RV/bus/truck parking
Nearby Two Star Indio hotels
In the hotel
- Free hot/cold buffet breakfast daily
- Outdoor pool
- Fitness facilities
- Spa tub
- Golf lessons available nearby
- Golfing nearby
- 24-hour business center
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Number of buildings/towers - 2
- Elevator/lift
- ATM/banking
- Safe-deposit box at front desk
- Designated smoking areas
- Accessible bathroom
- In-room accessibility
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Blackout drapes/curtains
- Sofa bed size double
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- 32-inch flat-screen TV
- Premium TV channels
- Free WiFi
- Free local calls
- Refrigerator
- Daily housekeeping
- Connecting/adjoining rooms available
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Quality Inn & Suites Indio I-10, Indio's small print
Also known as
- Quality Inn Indio I-10
- Quality Indio I-10
- Clarion Hotel Indio
- Quality Inn Indio I-10
- Quality Indio I-10
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Children under 12 years old are not allowed in the swimming pool or spa tub without adult supervision.
Optional extras
Rollaway beds are available for USD 10 per night
Pets are allowed for an extra charge of USD 25 per pet, per stay
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
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Occupational Therapy Australia is the national professional association representing occupational therapy in Australia.
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Baseball; The Season Belonged to the Sluggers
By MURRAY CHASS
Published: October 5, 1987
The St. Louis Cardinals and the San Francisco Giants enter the National League playoff tomorrow night with pitching staffs that have the lowest individual victory totals in championship series history. That's the kind of season it was.
Home-run hitters, not pitchers, dominated the season, slugging a record 4,457 home runs, 17 percent more than a year ago.
Andre Dawson of the Chicago Cubs, a free-agent transplant, and Mark McGwire of Oakland, a rookie, led their leagues with 49 home runs each, marking only the second time in major league history that the league leaders had that many home runs in the same season. In 1930, Hack Wilson hit 56 home runs and Babe Ruth had 49 in winning league home-run titles. Only three other times did pairs of players hit as many as 49 home runs in the same season, with Roger Maris (61) and Mickey Mantle (54) accomplishing the feat most recently, in 1961.
Despite their prodigious efforts, Dawson and McGwire did not propel their teams into the playoffs.
The league playoffs will begin tomorrow night with the Giants playing in St. Louis. The following night, the American League series will open with the Detroit Tigers playing the Minnesota Twins indoors in Minneapolis after charging from three and a half games back in the final eight days of the season. The Tigers bumped the Toronto Blue Jays, who squandered that lead in the process of losing their final seven games. Only two years ago, the Blue Jays had a three-games-to-one lead over Kansas City in the American League series but lost their last three games. Three 11-Game Winners
The Cardinals enter their third National League playoff in the last six seasons with three 11-game winners (Danny Cox, Greg Mathews and Bob Forsch) and one 10-game winner (John Tudor). The Giants go into their first post-season competition since 1971 with pitchers who have gained 13 victories (Mike LaCoss), 12 (Kelly Downs), 11 (Scott Garrelts) and 10 (Atlee Hammaker). Rick Reuschel has 13 victories and Dave Dravecky 10, but they won some of those games for other teams before being traded to the Giants.
Both pitching staffs thus eclipse the Pittsburgh Pirates of 1979 for having the most meager victory totals for playoff teams. That team of Pirates had pitchers with victory totals of 14, 13, 12, 12, 10 and 10.
The National League did not have a 20-game winner this season. Rick Sutcliffe of the Cubs was the leading winner with 18 victories. In the American League, Roger Clemens of Boston finished with a 20-9 record and Dave Stewart of Oakland was 20-13. Nolan Ryan of Houston had the most bizarre season of any pitcher, compiling an 8-16 record, but leading the National League with a 2.76 earned run average and 270 strikeouts.
Clemens's teammate, Wade Boggs, won his fourth batting title in the last five years with a .363 average, and Tony Gwynn of San Diego won his second with a .370 average, highest in the National League since Stan Musial batted .376 in 1948. Dawson, with 137, and George Bell of Toronto, with 134, led the leagues in runs batted in. Reynolds Is a Steal Leader
Perhaps the most significant individual leader was Harold Reynolds, who was the American League leader in stolen bases with 60. This is the first time in eight seasons that Rickey Henderson didn't lead the American League in steals. Henderson, who finished with 41, missed 67 games.
The longest hitting streak of the season was the 39-game streak of Paul Molitior of Milwaukee. Benito Santiago, the San Diego rookie, had a 34-game streak end on Saturday night.
Individual achievements were easier to duplicate than team championships. This is the ninth consecutive season in which the defending World Series champion will not repeat. None of the division champions repeated either. Of last year's four winners, the Mets were the only one to finish with a record better than .500.
The Tigers finished with the most victories, 98, but the Cardinals held first place the longest, 168 days of the 182-day season, including the 138 days from May 20 through yesterday.
The Tigers, who lost 19 of their first 30 games, didn't reach first place until Aug. 19, and then didn't hold the lead. In fact, after losing the first three games of a four-game series to Toronto last weekend, they plunged three and a half games back and were one inning away from dropping to four and a half when a game-tying home run by Kirk Gibson ignited their comeback. The Tigers won the title yesterday with a 1-0 victory over the Blue Jays.
The Twins finished with 85 victories, lowest total among this season's division champions, and a 29-52 road record, worst ever for a division winner. But the Twins moved into first place in the American League West on July 6 and remained there for 90 of the next 91 days.
The Cardinals romped through the National League East with a 61-32 record and a nine-and-a-half game lead up to July 23. They encountered difficulties after that, though, finishing their schedule with a 34-35 record.
In the National League West, the Cincinnati Reds appeared to be the strongest team and in fact, held first place for 106 days. However, in a 26-day period, from Aug. 7 through Sept. 1, the Reds lost 18 of 25 games while the Giants won 18 of 25. SEASON'S CHANGE How the number of victories each team finished with this season compares to the number it finished with last season. National Cardinals +16 Pirates +16 Expos +13 Giants +7 Cubs +6 Dodgers Even Reds -2 Braves -3 Phillies -6 Padres -9 Mets -16 Astros -20 American Brewers +14 Twins +14 Mariners +11 Tigers +11 Blue Jays +10 Royals +7 Athletics +5 White Sox +5 Yankees -1 Orioles -6 Rangers -12 Angels -17 Red Sox -17 Indians -23
photo of Roger Clemens and John Marzano (AP)


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Buy Platinum and Sell Gold 0 comments
Platinum's rarity and many industrial uses could bring about solid opportunities, and investors may consider lightening up on gold in favor of select, liquid equities that track platinum.
As gold prices have continued to make a series of new highs this year, platinum prices have languished. The platinum futures are current trading just over $1800, which is below the 2011 high of $1889. In March 2008, platinum made a high of $2308, so it is currently more than 27% below the all-time highs.
Of course, platinum is much more rare than gold, as the annual supply is estimated to be around 130 tons, which is just a fraction of the world's gold production. It terms of rarity, precious metal experts have concluded that platinum is 16 times more rare than gold.
The majority of the world's platinum comes from South African or Russian mines. In order to get one troy ounce of platinum, it takes ten tons of ore, which is generally mined in miserable conditions. A small amount of the world's platinum supply comes from Canada and the US.
Unlike gold, platinum has a number of industrial uses, with 80% going to the automotive industry for catalytic converters, although chemical companies also use a fair amount as well because platinum is resistant to corrosion.
The greater rarity of platinum and its extensive industrial demand are in clear contrast to this year's lagging price action relative to gold. Historically, this spread will eventually widen out, which will provide some interesting investing opportunities.
Click to Enlarge
Chart Analysis: This long-term chart features platinum prices on the top with the platinum/gold spread on the bottom. This chart goes back to 1995, showing the platinum price low of $332 in October 1998 as well as the 2008 high of $2308.
- Platinum prices have been in a range between $1658 and $1889 all year, and the uptrend, line a, is now at $1672
- The weekly on-balance volume (OBV) (not shown) is acting stronger than prices
- The spread is currently at $179 after hitting a recent low of $165. This spread had a high of $525 at the end of January
- The chart of the spread shows a well-defined downtrend with the 21-week weighted moving average (WMA) of the spread at $240. A move above this level would suggest that the spread had bottomed
Click to Enlarge
As for individual stocks, there are very few pure platinum plays, as the ore it is mined from also contains nickel and copper. Anglo American plc (AAUKY) is a very large, $53 billion company that in addition to mining platinum, also mines diamonds, coal, base metals, and iron ore. Additionally the company mines, processes, and refines the platinum group metals.
- The weekly chart looks quite similar to that of platinum prices. AAUKY has important chart support, line a, in the $21.60-$22.35 area. The longer-term uptrend, line b, is in the $19.40 area
- The weekly OBV did confirm the recent highs but has now dropped below its weighted moving average. The daily OBV (not shown) is neutral
- Prices seem ready to reverse to the downside this week, as they are below the highs at $24.35. Further resistance is in the $26.30-$27.53 area
There are several platinum ETFs or ETNs, but most have low average volumes, which means a wide bid/ask spread. ETFS Physical Platinum Shares (PPLT) seems to be the most liquid, trading with average daily volume over 60,000. It is designed to reflect the performance of the price of physical platinum, minus expenses.
- PPLT looks ready to close lower this week (chart updated through July 28), which would leave a bearish candle formation. The doji that formed in June (see circle) also led to a sharp decline
- There is initial support at $172 with more important support in the $166 area, line d. A violation of this level would indicate a drop to the 61.8% support at $163
- The weekly OBV is acting stronger than prices, as it made new highs this month. It is also above its rising weighted moving average. Longer-term OBV support is at line e
- The daily OBV (not shown) looks less positive
- Resistance from the previous peaks stands at $183 and $186.60
What It Means: It had been many years since I looked at the spread between platinum and gold, but commodity expert and active spread trader John Person suggested I take a look at the spread, which he found quite interesting. Though he had no formal recommendation for the spread, he did provide this information for those who were looking to trade this spread:
"The margin requirement is quite significant, the spread is $4,132.00. We would have to do a ratio quantity like two platinum to one gold, since gold is $100.00 per dollar move while platinum is $50.00"
See video: Wheat/Corn Spread Trade Is on Now
Though the spread is clearly at the lower end of its typical range, my analysis does not yet suggest that it has bottomed out. A pattern of higher highs and higher lows could be formed in the next few months.
Those who have a large, profitable position in gold ETFs like the Spyder Gold Trust (GLD) might consider selling some of their shares and scaling into a platinum ETF like PPLT.
How to Profit: The chart analysis for Anglo American plc (AAUKY) and ETFS Physical Platinum Shares (PPLT) suggests that they are likely to drop back to recent lows, which may provide a good entry point. Look for a test of support levels on AAUKY at $21.60-$22.30 and at $166-$171 for PPLT to signal buying opportunities.Back To TomAspray's Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Full index of posts »
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Hybrid apps: PhoneGap and Dojo Mobile on Android
Tom Young Tags: hybrid_apps android phonegap dojo_mobile 7,756 Views
Web apps have difficulty accessing many of our favorite mobile device functions, like accelerometers, GPS, camera, and such, and they usually can't run when disconnected from a network like native apps can. You also can't sell them in an app store. If these...
from Blog: Mobile development


text: FILE - In this Oct. 23, 2013 file photo protesters rally outside federal court during Detroit's bankruptcy proceedings. Judge Steven Rhodes, who is overseeing the case, found the city eligible to remake itself under Chapter 9 on Dec. 3 and also declared that pensions aren't immune to cuts in a final plan. (AP Photo/Paul Sancya, File)


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Renaissance Dana Point
Dana Point, CA 92629
- Sun 10am-2:30pm, Sun 4pm-9pm, Mon-Thu 11am-11pm, Fri-Sat 11am-12am
- $$
- Patio/Sidewalk Dining, Takeout, Wheelchair accessible
- Dinner, Lunch
- Full bar
- Parking Lot Available
- Reservations Accepted
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Top Definition
Bitch, also commonly known as a snitch that is a bad liar with studeration while talking.
"Stop burning me out your being a savadian"
dari Unkown11101 Jumat, 17 Mei 2013
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Email dikirim dari firstname.lastname@example.com. Kita nggak bakalan nge-spam kamu kok :).×


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Merchandise > USA > IL > Chicagoland
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Merchandise for Sale in 46323(1 - 15 of 41,790)
$450 Giant Plush Dinosaur Ride-on TricerotopsToys · Downers Grove, ILThis adorable Tricerotops ride on toy is perfect for the dinosaur enthusiast in your family. It measures approximately 51.5"L X 25"W X 37...Rand M. · 1 day ago
$950 Life-Size Fiberglass Toy Soldier Display (Christmas Decor) Indoor/OutdoorEverything Else · Lemont, ILRare Life-Size Toy Soldier Decor. Freestanding, hollow life-size figure of a toy soldier made from molded plastic/fiberglass. Gloss ename...Rand M. · 2 days ago
$1,300 (Price Drop) Fieldstone 9 piece good condition Maple CabinentsCabinets, Armoires & Cupboards · Oak Park, ILSlightly used Beautiful 9 piece custom Maple Cabinets. Uppers, lowers and sides. There are no sink cabinets because the owner used a farm...Renee E. ·6 listings · 1 day ago
$359 Sofa/ChaiseSofas · Chicago, ILI hate to part with this but I don't have room in my new apartment. This is a beautiful left-facing sofa/chaise (79" x 48") that is perfe...Brian C. · 5 days ago
$5 Store Returns Auction 9/22Everything Else · Shorewood, ILhttp://www.shorewoodliquidators.com/buy/slibuy/ has premium items including tools, electronics, furniture, appliances, lawn & garden equi...Karen B. · 5 days ago
$100 magazine collectionMagazines · Chicago, ILI have the whole collection of Epic magazines - minus 3 normal average magazines you can pick up on eBay for about five or ten dollars I ...Alex S. · 5 days ago
$35 Sony DVD Player Model DVP-NS300DVD players · Chicago, ILBarely used Sony DVD Video Player DVP-NS300 with AV Cables and Remote Control Batteries not IncludedRimma G. · 1 week ago
$5 Comic Books for SaleBooks & Magazines · Chicago, ILI have a huge comic book collection bought 15 years ago. Mostly DC Superhero Titles Batman, Justice League and many more Some Indie Publ...Rimma G. · 1 week ago
$695 RARE - Giant Life-Size Toy Playmobil Knight Figure Decor 5'HEverything Else · Lemont, ILRare, out of production, Life-Size Toy Playmobil Knight Figure. 5 feet tall. Arms and head swivel. Shield and sword interchangeable. Pain...
$1 Wanted: Wanted Quality Dollhouses & Miniature Furniture to sell on Consignment @ OakridgEverything Else · Lemont, ILWANTED - Quality Assembled Dollhouses & Miniature Dollhouse Furniture @ Oakridge Hobbies (Lemont IL) Oakridge Hobbies, in Lemont IL, is ...
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$450 Life-Size Studio Plush Ride-On TigerToys · Downers Grove, ILComplete your "zoo" with this large stuffed Bengal tiger. The tiger measures Standing 50"L x 35" Tall and weighs approximately 25 lbs. Th...
$500 cxhjidfidhfidfhdkfhdjgfd Charming young Golden Retriever puppies ready for loveEverything Else · Jefferson Park, IL… . Well established to a housebreaking routine, vaccination...Silvia P. · 1 week ago
$275 (Price Drop) A Wood/Gas Burning, Top Vent, White Brick Fireplace ComboOther Furniture · Oak Park, IL42" Never used Wood/Gas combo fire place insert. Must use IHP, FMI, or Comfort Flame 8" wood burning chimney pipe Includes log grate and...Renee E. ·6 listings · 1 week ago
$1,400 (Price Drop) 9 new Double Pane Windows with tilt to cleaningOther Furniture · Oak Park, ILBeautiful ASSORTED DOUBLE PANE WINDOWS that tilt for easy clean and White Panel Doors. If your a rehabber or owns rental property, these ...Renee E. ·6 listings · 1 week ago
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Go For It!
Go For It discovers the weirdest and most unique skills that our nation has to offer and put them to the test. Each week, challengers get the chance to show off to the nation and win £1000 in cash on the spot if they successfully complete their unusual s
Stephen takes to the Text Santa stage!
Stephen joins Holly Willoughby, Phillip Schofield, Christine Bleakley, Amanda Holden, Paddy McGuinness, Alesha Dixon, Caroline Flack and Olly Murs for the Text Santa Christmas Jumper Day extravaganza!
Stephen stars in Cinderella this Christmas!
This Christmas, don't miss Fairfield Halls' spectacular, fun-filled, family pantomime Cinderella, starring Stephen.
Vote for Stephen in the NTAs!
The nominations have been announced, and you could decide who wins!
Stephen joins the Cobbles!
Catch Stephen on ITV2 after Corrie's dramatic live episode that celebrate ITV's 60th anniversary.
Win with Stephen's #BigStarGiveaway
Fancy being Stephen's BGT Vip? Tune in to Big Star's Little Star and answer Stephen's Twitter question for your chance to win!
Big Star's is back!
Stephen hosts a brand new series of this fun-filled family entertainment show, Big Star's Little Star, which lifts the lid on celebrities' lives – through the eyes of their children.
Reality Bites: A pint-sized preview!
Amy Childs takes part in the Big Fact Hunt round where the teams have to guess whether statements about her are true or false.
Page 1 of 9 Next »


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Home > Sunglasses > Humphrey > HU 585193 (14)
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HU 585193/14 Ophthalmic Glasses
These sunglasses complement your look with an accessory that is a cut above the rest. True to the Edel-Optics motto "SEE AND BE SEEN", you are on a par with celebrities, impressing in every environment. The HU 585193 is available in the Edel-Optics online shop in other styles from Humphrey collections 2015 and 2016.
With no frills and state-of-the-art materials and craftsmanship, these men's glasses stand for stylish design and self-confidence. Black is one of the undisputed classics. It can be combined with any outfit and simultaneously radiates elegance and naturalness. This brand of sunglasses, of course, also provides your eyes with optimum UV400 protection.
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text:
All you guys with guns in the back of you pickups better load them.
They can take my guns one bullet at a time.
Watch it Freedom lovers are hated by yahoo secret police you will be reviled!
We keep the terrorists off our shore and on the defensive by stationing troops on THEIR shores.
Who in their right mind considers gollum human??
The left and minouaties have left us humans 0 choice. I can see the the traitors in boats bound for africa and cuba.. Imagine if they didnt have holes in the bottom.
Think of the POS that owns 60% of this thing. What does it care it gets interviews on the lefty stations so it can tout its life style. Fruiters and transvestites for ever.
Some plan to send money to gollum. The valley always supports SCUMBAGS and quadroons.
Stupidity and ignorance benefits no one. The wh is filled with both these sines. We must remove this blight from our land.
You sound like a gollum supporter ..... the economy is BOOMINGGGGGGGGGGGGGGGGG.
Hey saw you are discounting your sperm receptacles services..... $1 is still too high
only syph has siri
Thank god we will be rid of this defecation and the rotten left in the senate.
gollums supporter are of the lowest species possible and yet they knock our next President
Hell they run their VWs on air. How will they get to the welfare office for another extra check? Will the demorats drive them to the polls so they can vote 20 times?
Why speak that way about gollum the quadroon? From your mouth to gods ears
They give it to illegals, blood sucking unions, lazy welfare #$%$ and crooked banks. The average working American gets ZIP
Quadroons and fruiters are your heroes are you also the product of bestiality?
Must have been Reagan ... couldnt be caused by the quadroon in chief.
Just bought your mother for $.002 ... too muck
Even the dumbest lefty (unless on welfare) would not do it ... agin


text:
Transdermal fentanyl ("patches")
Reminder of the potential risk of life-threatening harm from accidental exposure
PosologyFentanyl transdermal patches release the active substance over 72 hours. The fentanyl release rate is 12, 25, 50, 75 and 100 microgram/hour and the corresponding active surface area is 4.2, 8.4, 16.8, 25.2 and 33.6 cm2.The required fentanyl dosage is adjusted individually and should be assessed regularly after each administration.
Choice of initial dosageThe dosage level of fentanyl is based upon the previous use of opioids and takes into account the possible development of tolerance, concomitant medicinal treatment, the patient's general state of health and the degree of severity of the disorder.
Adults:Opioid-tolerant patientsTo convert opioid-tolerant patients from oral or parenteral opioids to Matrifen refer to Equianalgesic potency conversion below. The dosage may subsequently be titrated upwards or downwards, if required, in increments of either 12 or 25 mcg/hr to achieve the lowest appropriate dose of Matrifen depending on response and supplementary analgesic requirements.Opioid-naive patientsThe initial dosage should not exceed 12 micrograms/hour when the opioid response pattern for the pain condition is not fully known.Clinical experience with fentanyl transdermal patch is limited in opioid-naïve patients. In the circumstances in which therapy with fentanyl transdermal patch is considered appropriate in opioid-naïve patients, it is recommended that these patients be titrated with low doses of immediate release opioids (e.g., morphine, hydromorphone, oxycodone, tramadol, and codeine) to attain equianalgesic dosage relative to fentanyl transdermal patch. Patients can then be converted to fentanyl transdermal patch. The dose may subsequently be titrated upwards or downwards, if required, in increments of 12 or 25 mcg/hr to achieve the lowest appropriate dose of fentanyl transdermal patch depending on the response and supplementary analgesic requirements (see also section 4.4 Special warnings and precautions for use: Opioid naïve and not opioid-tolerant states).
Equianalgesic potency conversion1. Calculate the previous 24-hour analgesic requirement.2. Convert this amount to the equianalgesic oral morphine dose using Table 1. All IM and oral doses in this chart are considered equivalent to 10 mg of IM morphine in analgesic effect.3. To derive the dosage of Matrifen corresponding to the calculated 24-hour, equianalgesic morphine dosage, use the dosage-conversion Table 2 or Table 3 as follows:Table 2 is for adult patients who have been stabilised on oral morphine or another immediate-release opioid over several weeks and who need opioid rotation (conversion ratio of oral morphine to transdermal fentanyl approximately equal to 150:1). Table 3 is for highly opioid-tolerant adult patients who have been on a stable and well-tolerated opioid regimen for a long period, and who need opioid rotation (conversion ratio of oral morphine to transdermal fentanyl approximately equal to 100:1).Tables 2 and 3 should not be used to switch from transdermal fentanyl to another opioid treatment.
Table 1: Equianalgesic potency conversion
Name of medicinal product
Equianalgesic dosage (mg)
30 - 40 (assuming repeated administration)**
60 (assuming a single dose or occasional doses)
10 (rectal)
0.8 (sublingual)
Oral morphine dose per 24-hours (mg/day)
Dose of Matrifen transdermal patch micrograms/hour
Oral morphine dose per 24-hours (mg/day)
Dose of Matrifen transdermal patch micrograms/hour
< 44
Dose titration and maintenance therapyThe patch should be replaced every 72 hours. The dose should be titrated individually until a balance between analgesic efficacy and tolerability is attained. In patients who experience a marked decrease in the period 48-72 hours after application, replacement of fentanyl after 48 hours may be necessary. The dose 12 micrograms/hour is appropriate for dose titration in the lower dosage area. If analgesia is insufficient at the end of the initial application period, the dose may be increased after 3 days, until the desired effect is obtained for each patient. Additional dose adjustment should normally be performed in 12 micrograms/hour or 25 micrograms/hour increments, although the supplementary analgesic requirements and pain status of the patient should be taken into account. More than one patch may be used for dose adjustments and for doses greater than 100 micrograms/hour. Patients may require periodic supplemental doses of a short-acting analgesic for breakthrough pain. Additional or alternative methods of analgesia or alternative administration of opioids should be considered when the Matrifen dose exceeds 300 micrograms/hour.Opioid withdrawal symptoms (see section 4.8, Undesirable effects) have been reported when changing from long-term treatment with Morphine to transdermal fentanyl despite adequate analgesic efficacy. In case of withdrawal symptoms it is recommended to treat those with short-acting Morphine in low doses.
Discontinuation of MatrifenIf discontinuation of the patch is necessary, any replacement with other opioids should be gradual, starting at a low dose and increasing slowly. This is because fentanyl levels fall gradually after the patch is removed; it takes at least 17 hours for the fentanyl serum concentration to decrease by 50% (see section 5.2). As a general rule, the discontinuation of opioid analgesia should be gradual, in order to prevent withdrawal symptoms (nausea, vomiting, diarrhea, anxiety and muscular tremor).Table 2 and Table 3 should not be used to convert from Matrifen to other therapies to avoid overestimating the new analgesic dose and potentially causing overdose.
Use in older peopleElderly or cachectic patients should be observed carefully and the dose reduced if necessary (see section 4.4).
Use in patients with hepatic or renal impairmentPatients with impaired hepatic or renal function should carefully be observed for symptoms of an overdosage and the dose should possibly be reduced (see section 4.4).
Use in febrile patientsDose adjustment may be necessary in patients during episodes of fever (see section 4.4).
Use in paediatric populationChildren aged 16 years and above: follow adult dosage.Children aged 2 to 16 years old:Matrifen should be administered only to opioid-tolerant paediatric patients (ages 2 to 16 years) who are already receiving at least 30 mg oral morphine equivalent per day. To convert paediatric patients from oral or parenteral opioids to Matrifen, refer to Equianalgesic potency conversion (Table 1), and Recommended initial Matrifen dose based upon daily oral morphine dose (Table 4). Table 4: Recommended initial dose of Matrifen based upon daily oral morphine dose1
Oral morphine dose per 24-hours (mg/day)
Dose of Matrifen transdermal patch micrograms/hour
For paediatric patients2
For paediatric patients2
Dose titration and maintenance.If the analgesic effect of Matrifen is insufficient, supplementary morphine or another short-duration opioid should be administered. Depending on the additional analgesic needs and the pain status of the child, it may be decided to increase the dose. Dose adjustments should be done in 12 micrograms/hour steps.
Method of administrationFor transdermal use.Fentanyl transdermal patch should be applied to non-irritated and non-irradiated skin on a flat surface of the torso or upper arm. In young children the upper back is the preferred location to apply the patch, to minimize the potential of the child removing the patch. Hair at the application site (hairless area is preferred) should be clipped (not shaved) prior to system application. If the site requires to be cleansed prior to application of the patch, this should be done with water. Soaps, oils, lotions, alcohol or any other agent that might irritate the skin or alter its characteristics should not be used. The skin should be completely dry before application of the patch. Patches should be inspected prior to use. The transdermal patch should not be divided or cut (see section 4.4) Patches that are cut, divided, or damaged in any way should not be used.Since the transdermal patch is protected outwardly by a waterproof covering foil, it may also be worn when taking a short shower.The Matrifen patch should be removed from the protective pouch by first folding the notch (located close to the tip of the arrow on the pouch label) and then carefully tearing the pouch material. If scissors are used to open the pouch, this should be done close to the sealed edge so as not to damage the patch inside.Fentanyl transdermal patch is to be attached as soon as the pack has been opened and avoid touching the adhesive side of the patch.Following removal of the protective layer, the transdermal patch should be pressed firmly in place with the palm of the hand for approximately 30 seconds, making sure the contact is complete, especially around the edges. An additional fixing of the transdermal patch may be necessary. . Then wash hands with clean water. Fentanyl transdermal patch should be worn continuously for 72 hours after which the transdermal patch is replaced. A new transdermal patch should always be applied to a different site from the previous one. The same application site may be re-used only after an interval of at least 7 days.For disposal instructions see section 6.6.
Respiratory depressionAs with all potent opioids some patients may experience significant respiratory depression with the fentanyl transdermal patch; patients must be observed for these effects. Respiratory depression may persist beyond the removal of the patch. The incidence of respiratory depression increases as the fentanyl dose is increased (see Section 4.9, Overdose, concerning respiratory depression). CNS active drugs may increase the respiratory depression (see section 4.5, Interactions with other medicinal products and other forms of interaction).
Serotonin SyndromeCaution is advised when fentanyl transdermal patches is coadministered with drugs that affect the serotonergic neurotransmitter systems. The development of a potentially life-threatening serotonin syndrome may occur with the concomitant use of serotonergic drugs such as Selective Serotonin Re-uptake Inhibitors (SSRIs) and Serotonin Norepinephrine Re-uptake Inhibitors (SNRIs), and with drugs which impair metabolism of serotonin (including Monoamine Oxidase Inhibitors [MAOIs]). This may occur within the recommended dose. Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g, tachycardia, labile blood pressure, hyperthermia), neuromuscular abnormalities (e.g. hyper-reflexia, incoordination, rigidity), and/or gastrointestinal symptoms (e.g, nausea, vomiting, diarrhoea). If serotonin syndrome is suspected, rapid discontinuation of fentanyl transdermal patches should be considered.
Chronic pulmonary diseaseFentanyl may have more severe adverse effects in patients with chronic obstructive or other pulmonary disease. In such patients, opioids may decrease respiratory drive and increase airway resistance.
Drug dependence and potential for abuseTolerance, physical dependence, and psychological dependence may develop upon repeated administration of opioids such as fentanyl. Iatrogenic addiction following opioid administration is rare. Patients with a prior history of drug dependence/alcohol abuse are more at risk to develop dependence and abuse in opioid treatment. Patients at increased risk of opioid abuse may still be appropriately treated with modified-release opioid formulations; however, these patients will require monitoring for signs of misuse, abuse, or addiction. Fentanyl can be abused in a manner similar to other opioid agonists. Abuse or intentional misuse of Matrifen may result in overdose and/or death.
Increased intracranial pressureMatrifen should be used with caution in patients who may be particularly susceptible to the intracranial effects of CO2 retention such as those with evidence of increased intracranial pressure, impaired consciousness, or coma. Fentanyl should be used with caution in patients with brain tumors.
Cardiac diseaseFentanyl may produce bradycardia and should therefore be administered with caution to patients with bradyarrhythmias.Opioids may cause hypotension, especially in patients with acute hypovolaemia. Underlying, symptomatic hypotension and/or hypovolaemia should be corrected before treatment with fentanyl transdermal patches is initiated.
Hepatic impairmentBecause fentanyl is metabolised to inactive metabolites in the liver, hepatic impairment might delay its elimination. If patients with hepatic impairment receive transdermal fentanyl, they should be observed carefully for signs of fentanyl toxicity and the dose of fentanyl reduced if necessary (see Section 5.2, Pharmacokinetic properties).
Renal impairmentLess than 10% of fentanyl is excreted unchanged by the kidney and, unlike morphine, there are no known active metabolites eliminated by the kidney. If patients with renal impairment receive transdermal fentanyl they should be observed carefully for signs of fentanyl toxicity and the dose reduced if necessary (see Section 5.2, Pharmacokinetic properties).
Fever/external heat applicationA pharmacokinetic model suggests that serum fentanyl concentrations may increase by about one-third if the skin temperature increases to 40° C.Therefore, patients with fever should be monitored for opioid side effects and the fentanyl dose should be adjusted if necessary. There is a potential for temperature-dependent increases in fentanyl released from the system resulting in possible overdose and death. A clinical pharmacology trial conducted in healthy adult subjects has shown that the application of heat over a fentanyl transdermal system increased mean fentanyl AUC values by 120% and mean Cmax values by 61%.All patients should be advised to avoid exposing the Fentanyl transdermal patch application site to direct external heat sources such as heating pads, electric blankets, heated water beds, heat or tanning lamps, intensive sunbathing, hot water bottles, prolonged hot baths, saunas and hot whirlpool spa baths while wearing the patch, since there is potential for temperature dependent increases in release of fentanyl from the patch..
Interactions with other Medicinal ProductsInteractions with CYP3A4 Inhibitors:The concomitant use of transdermal fentanyl with cytochrome P450 3A4 (CYP3A4) inhibitors (e.g. ritonavir, ketoconazole, itraconazole, troleandomycin, clarithromycin, erythromycin, nelfinavir, nefazodone, verapamil, diltiazem, and amiodarone) may result in an increase in fentanyl plasma concentrations, which could increase or prolong both the therapeutic and adverse effects, and may cause serious respiratory depression. In this situation special patient care and observation are appropriate. Therefore, the concomitant use of transdermal fentanyl and CYP3A4 inhibitors is not recommended unless the patient is closely monitored. Patients, especially those who are receiving transdermal fentanyl and CYP3A4 inhibitors, should be monitored for signs of respiratory depression and dosage adjustments should be made if warranted.
Older PatientsData from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged half-life and they may be more sensitive to the drug than younger patients. If elderly patients receive transdermal fentanyl, they should be observed carefully for signs of fentanyl toxicity and the dose reduced if necessary (see Section 5.2, Pharmacokinetic properties).
Gastrointestinal TractOpioids increase the tone and decrease the propulsive contractions of the smooth muscle of the gastrointestinal tract. The resultant prolongation in gastrointestinal transit time may be responsible for the constipating effect of fentanyl. Patients should be advised on measures to prevent constipation and prophylactic laxative use should be considered. Extra caution should be used in patients with chronic constipation. If paralytic ileus is present or suspected, treatment with fentanyl patch should be stopped.
Accidental Exposure by Patch TransferAccidental transfer of a fentanyl patch to the skin of a non-patch wearer (particularly a child), while sharing a bed or being in close physical contact with a patch wearer, may result in an opioid overdose for the non-patch wearer. Patients should be advised that if accidental patch transfer occurs, the transferred patch must be removed immediately from the skin of the non-patch wearer. (see section 4.9 Overdose)
Use in paediatricsMatrifen should not be administered to opioid naïve paediatric patients (see section 4.2 Posology and method of administration). The potential for serious or life-threatening hypoventilation exists regardless of the dose of Matrifen transdermal system administered.Fentanyl transdermal patch was not studied in children under 2 years of age. Matrifen should be administered only to opioid-tolerant children age 2 years or older (see section 4.2 Posology and method of administration). Matrifen should not be used in children under 2 years of age.To guard against accidental ingestion by children, use caution when choosing the application site for Matrifen (see section 4.2 Posology and method of administration) and monitor adhesion of the patch closely.
LactationAs fentanyl is excreted into breast milk, breastfeeding should be discontinued during treatment with transdermal fentanyl (see also Section 4.6).
Patients with myasthenia gravisNon-epileptic (myo)clonic reactions can occur. Caution should be exercised when treating patients with myasthenia gravis.
Concomitant use of mixed agonists/antagonistsThe concomitant use of buprenorphine, nalbuphine or pentazocine is not recommended (see also Section 4.5).
Monoamine Oxidase Inhibitors (MAOI):Transdermal fentanyl is not recommended for use in patients who require the concomitant administration of an MAOI. Severe and unpredictable interactions with MAOIs, involving the potentiation of opiate effects or the potentiation of serotoninergic effects, have been reported. Therefore, fentanyl should not be used within 14 days after discontinuation of treatment with MAOIs.
Serotonergic DrugsCoadministration of transdermal fentanyl with a serotonergic agent, such as a Selective Serotonin Re-uptake Inhibitor (SSRI) or a Serotonin Norepinephrine Re-uptake Inhibitor (SNRI) or a Monoamine Oxidase Inhibitor (MAOI), may increase the risk of serotonin syndrome, a potentially life-threatening condition.
Concomitant use of mixed agonists/antagonistsThe concomitant use of buprenorphine, nalbuphine or pentazocine is not recommended. They have high affinity to opioid receptors with relatively low intrinsic activity and therefore partially antagonise the analgesic effect of fentanyl and may induce withdrawal symptoms in opioid dependent patients (see also Section 4.4).
PregnancyThere are no adequate data from the use of transdermal fentanyl in pregnant women. Studies in animals have shown some reproductive toxicity (see section 5.3 Preclinical safety data). The potential risk for humans is unknown, although fentanyl as an IV anesthetic has been found to cross the placenta in early human pregnancies. Neonatal withdrawal syndrome has been reported in newborn infants with chronic maternal use of transdermal fentanyl during pregnancy. Transdermal fentanyl should not be used during pregnancy unless clearly necessary.Use of transdermal fentanyl during childbirth is not recommended because it should not be used in the management of acute or postoperative pain (see Section 4.4, Special warnings and precautions for use). Moreover, because fentanyl passes through the placenta, the use of transdermal fentanyl during childbirth might result in respiratory depression in the newborn infant.
BreastfeedingFentanyl is excreted into breast milk and may cause sedation and respiratory depression in the breastfed infant. Breastfeeding should therefore be discontinued during treatment with transdermal fentanyl and for at least 72 hours after removal of the patch.
System Organ Class
Adverse Drug Reactions
Frequency Category
Very Common
Not Known
Immune System Disorders
Anaphylactic shock, Anaphylactic reaction, Anaphylactoid reaction
Metabolism and Nutrition Disorders
Psychiatric Disorders
Insomnia, Depression, Anxiety, Confusional state, Hallucination
Agitation, Disorientation, Euphoric mood
Nervous System Disorders
Somnolence, Dizziness, Headache
Tremor, Paraesthesia
Hypoaesthesia, Convulsion (including clonic convulsions and grand mal convulsion), Amnesia, Depressed level of consciousness, Loss of consciousness
Eye Disorders
Ear and Labyrinth Disorders
Cardiac Disorders
Palpitations, Tachycardia
Bradycardia, Cyanosis
Vascular Disorders
Respiratory, Thoracic and Mediastinal Disorders
Respiratory depression, Respiratory distress
Apnoea, Hypoventilation
Gastrointestinal Disorders
Nausea, Vomiting, Constipation
Diarrhoea, Dry mouth, Abdominal pain, Abdominal pain upper, Dyspepsia
Skin and Subcutaneous Tissue Disorders
Hyperhidrosis, Pruritus, Rash, Erythema
Eczema, Dermatitis allergic, Skin disorder, Dermatitis, Dermatitis contact
Musculoskeletal and Connective Tissue Disorders
Muscle spasms
Muscle twitching
Renal and Urinary Disorders
Urinary retention
Reproductive System and Breast Disorders
Erectile dysfunction, Sexual dysfunction
General Disorders and Administration Site Conditions
Fatigue, Oedema peripheral, Asthenia, Malaise, Feeling cold
Application site reaction, Influenza like illness, Feeling of body temperature change, Application site hypersensitivity, Drug withdrawal syndrome, Pyrexia
Application site dermatitis, Application site eczema
Paediatric SubjectsThe adverse event profile in children and adolescents treated with fentanyl transdermal patch was similar to that observed in adults. No risk was identified in the paediatric population beyond that expected with the use of opioids for the relief of pain associated with serious illness and there does not appear to be any paediatric-specific risk associated with fentanyl transdermal patch use in children as young as 2 years old when used as directed. Very common adverse events reported in paediatric clinical trials were fever, vomiting and nausea.The safety of fentanyl transdermal patch was evaluated in 289 paediatric subjects (<18 years) who participated in 3 clinical trials for the management of chronic or continuous pain of malignant or non-malignant origin. These subjects took at least one dose of fentanyl transdermal patch and provided safety data. Although the enrolment criteria for the paediatric studies restricted enrolment to subjects who were a minimum of 2 years of age, 2 subjects in these studies received their first dose of fentanyl transdermal patch at an age of 23 months.Based on pooled safety data from these 3 clinical trials in paediatric subjects, the most commonly reported (ie ≥10% incidence) Adverse Drug Reactions (ADRs) were (with % incidence): vomiting (33.9%), nausea (23.5%), headache (16.3%), constipation (13.5%), diarrhoea (12.8%), and pruritus (12.8%). Table 6 displays all ADRs reported in fentanyl transdermal patch-treated paediatric subjects in the aforementioned clinical trials.The ADRs for the paediatric population presented in Table 6 were assigned to frequency categories using the same conventions as used for Table 5.Table 6: Adverse Drug Reactions in Paediatric Subjects in clinical trials
System Organ Class
Adverse Drug Reactions
Frequency Category
Very Common (≥1/10)
Immune System Disorders
Metabolism and Nutrition Disorders
Psychiatric Disorders
Insomnia Somnolence, Anxiety, Depression, Hallucination
Confusional state
Nervous System Disorders
Dizziness, Tremor, Hypoaesthesia,
Eye Disorders
Ear and Labyrinth Disorders
Cardiac Disorders
Respiratory, Thoracic and Mediastinal Disorders
Respiratory depression,
Gastrointestinal Disorders
Nausea, Vomiting, Constipation, Diarrhoea,
Abdominal pain, Abdominal pain upper, Dry mouth
Skin and Subcutaneous Tissue Disorders
Rash, Hyperhidrosis, Erythema
Contact dermatitis, Skin disorder, Allergic dermatitis, Eczema,
Musculoskeletal and Connective Tissue Disorders
Muscle spasms
Renal and Urinary Disorders
Urinary retention
General Disorders and
Administration Site
Peripheral oedema Fatigue,
Application site reaction,
Drug withdrawal syndrome,
Influenza-like illness
SymptomsThe manifestations of fentanyl overdose are an extension of its pharmacological actions, the most serious effect being respiratory depression.
TreatmentFor management of respiratory depression immediate countermeasures include removing the patch and physically or verbally stimulating the patient. These actions can be followed by administration of a specific opioid antagonist such as naloxone. Respiratory depression following an overdose may outlast the duration of action of the opioid antagonist. The interval between IV antagonist doses should be carefully chosen because of the possibility of re-narcotization after the patch is removed; repeated administration or a continuous infusion of naloxone may be necessary. Reversal of the narcotic effect may result in acute onset of pain and release of catecholamines. If the clinical situation warrants, a patent airway should be established and maintained, possibly with an oropharyngeal airway or endotracheal tube, and oxygen should be administered and respiration assisted or controlled, as appropriate. Adequate body temperature and fluid intake should be maintained.If severe or persistent hypotension occurs, hypovolaemia should be considered, and the condition should be managed with appropriate parenteral fluid therapy.
Paediatric populationThe safety of transdermal fentanyl was evaluated in three open-label trials in 289 paediatric patients with chronic pain, 2 years of age through to 18 years of age, of which 66 children were aged to 2 to 6 years. In these studies, 30 mg to 45 mg oral morphine per day was replaced by one transdermal fentanyl 12 microgram/h patch. Starting dose of 25 microgram/h and higher were used by 181 patients who had been on prior daily opioid doses of at least 45 mg per dose of oral morphine
AbsorptionAfter the first patch application serum fentanyl concentrations increase gradually, generally levelling off between 12 and 24 hours and remaining relatively constant for the remainder of the 72-hour application period. By the second 72-hour application, a steady- state serum concentration is reached and is maintained during subsequent applications of the patch of the same size. The absorption of fentanyl may differ somewhat between different application sites. A somewhat lower (approximately 25%) fentanyl absorption has been observed in studies with healthy volunteers after the patch has been applied on the chest compared with the upper arm and the back.
DistributionThe plasma protein binding for fentanyl is 84 %.
BiotransformationFentanyl shows linear kinetics and is metabolized primarily in the liver via CYP3A4. The major metabolite, norfentanyl, is inactive.
EliminationAfter the fentanyl patch is removed, serum fentanyl concentrations decline gradually falling approximately 50% in 13-22 hours in adults or 22-25 hours in children. Continued absorption of fentanyl from the skin accounts for a slower disappearance of the drug from the serum than is seen after an intravenous infusion. Around 75% of fentanyl is excreted into the urine, mostly as metabolites, with less than 10% as unchanged drug. About 9% of the dose is recovered in the faeces, primarily as metabolites.
Pharmacokinetics in special groupsImpaired hepatic or renal function could cause increased serum concentrations. Elderly, cachectic or generally impaired patients may have a lower fentanyl clearance, which could cause a longer terminal half life for the compound (see section 4.2 and 4.4).
Paediatric populationAdjusting for body weight, clearance (L/hr/Kg) in paediatric patients appears to be 82 % higher in children 2 to 5 years old and 25 % higher in children 6 to 10 years old when compared to children 11 to 16 years old, who are likely to have the same clearance as adults. These findings have been taken into consideration in determining the dosing recommendations for paediatric patients.
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Fred's Reviews > The Difference Between You and Me
The Difference Between You and Me
by Madeleine George
by Madeleine George
Fred's review
bookshelves: srsly-tbr-asap
Apr 05, 2012
bookshelves: srsly-tbr-asap
Read from April 04 to 05, 2012
Review to follow. I liked this 4 stars worth, felt that it got a little didactic at points, and wished that the character I liked didn't have it so conflicted. But a good one, with a great MC, intense emotions and secrets - those are basically my three keys to a good book!
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|"Hmm, not quite what I expected. I thought I'd be rooting for the quirky one and disapproving of the yearbook hog. But they are both messed up, just in different ways, not sure if their "relationship," if there's enough there to call it that, can pull them through without a whole lotta hurt goin' on."
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Dallas-Fort Worth continues to be a top-ten U.S. market for technology patent generation in the areas of computers, IT, telecom, and biotech.
The data center market supply in Dallas remains tight so far in 2016, with only a handful of wholesale providers offering blocks of available supply.
The construction pipeline continues to churn across Dallas, with construction rates above the market's historical averages.
With vacancies near all-time lows, rents rising and investment activity strong, competition for Skyline product remains fierce.
Visit the JLL Dallas blog Sixty by Eighty for the latest research and insight.
Learn more about our professionals and how they've helped clients throughout the Dallas-area with their commercial real estate needs.
View properties for lease and for sale in the Dallas-area.
Leverage our industry-leading real estate research to make more informed commercial real estate decisions.
We've made a habit of providing real value to our clients. Find out what we've done and who we've done it for.


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- Axle/Half Shaft Replacement - Front
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- Battery Replacement
- Brake Caliper Replacement - Front
- Brake Caliper Replacement - Rear
- Brake Fluid Replacement/Flush
- Brake Hose Replacement
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Branding Bans:
A step too far
Idil Yasa, JT International S.A., addresses the rise in plain packaging laws and what they mean for the future of branding.
Trademark assets: A big deal in
Rob Davey, Senior Director, Global Services, Thomson CompuMark, explores the importance of trademark reviews and validation in the due diligence process, especially those involved in mergers and megamergers.
Food and drink fraud: A global threat
Stuart Fuller, NetNames, comprehensively discusses the
growing concern of counterfeited food and drink merchandise.
Madrid refusals in Russia
Alexander Baranchikov, Lead Lawyer, RUPTO Attorney
No. 1719, addresses issues related to designating Russia
in an international trademark application.
Cover Story: The color dispute is still in PLAY
Marta Koremba, Bird & Bird, looks into the legal debate of trademarks based per se on colors, and the way this matter is handled in Poland.
The possible repercussions of Brexit
The Trademark Lawyer Magazine has conducted an interview with Ricardo Blancaflor, Romulo Mabanta Buenaventura Sayoc & De Los Angeles, discussing his opinions of the Brexit decision.
The right of personal name registration in China
Kevin Xu (Xu Kai) and Mandy Wang (Wang Xi), HongFangLaw, discuss the complicated laws of personal name registration in China.
Angolan trademarks
Tiago Reis Nobre and Vítor Palmela Fidalgo, Inventa International, discuss the progress and difficulties of intellectual property in Africa and why this means more countries from the developed world should invest there.
Brexit and IP rights in the UK: What next?
Myles Jelf, Bristows, looks closely into Britain's decision to 'Brexit', and how this will impact the different aspects of intellectual property law.
The FICPI 16th Open Forum
FICPI's 16th Open Forum is on the 5-8 October 2016 in St Petersburg, Russia, and it's going to be one to remember. Dr. Alexander Wyrwoll, President of the Communications Commission, tells us why you should attend the conference this year.
No extraterritorial jurisdiction for the Mexican Institute of IP
Abraham Diaz, Olivares, explores the limits of the territorial jurisdiction of IMPI in a landmark case.
Mexican trademark amendment
A modification to IPL in Mexico was made in June, establishing an opposition to current trademark registration. Gilberto Sanchez, SPECIFIC IP, explains.


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Realize Your Dream
Upcoming Events
Wyatt Smith, '09, in Concert
Oct 09
Watertown, WI
- Luther Preparatory School
- October 09, 2016 — 3:00PM
- Admission: Free
- More Info
Alumnus Wyatt Smith returns to Luther Preparatory to celebrate the newest Berghaus pipe organ.
Organ Concert with Jay Yau
Oct 09
Naperville, IL
- St. Raphael Catholic Church
- October 09, 2016 — 4:00PM
- Admission: Free Will Offering
- More Info
The organist at Sts. Peter and Paul Catholic Church will play "France and Germany: A Tour Through the Ages" featuring music of Dumage, Krebs, Franck and others. Featuring the Berghaus organ.
Bach Cantata Vespers
Oct 30
River Forest, IL
- Grace Lutheran Church
- October 30, 2016 — 3:45PM
- Admission: Free Will Offering
- More Info
Schmücke dich, o liebe Seele (Deck thyself, O dear soul)
Berghaus Organ at St. Benedict's
Nov 05
Chesapeake, VA
- St. Benedict's Parish
- November 05, 2016 — 7:00PM
- Admission: Free Will Offering
- More Info
Marie-Bernadette Dufourcet-Hakim will play a special performance on the 2014 Berghaus Organ at this beautiful church.
Marie-Bernadette Dufourcet-Hakim in Concert
Nov 05
Chesapeake, VA
- St. Benedict's Parish
- November 05, 2016 — 7:00PM
- More Info
The internationally acclaimed French organist, heard at the 2016 AGO convention, will play a very special concert on the 2014 Berghaus organ.
Parkey OrganBuilders Opus 12 at East Texas Pi
Nov 08
Shreveport, LA
- Cathedral of St. John Berchmans
- November 08, 2016 — 04:00pm
- More Info
We are pleased to announce that Parkey OrganBuilders Opus 12, located at the Cathedral of St. John Berchmans in Shreveport, Louisiana, will be a featured instrument at the 2016 East Texas Pipe Organ Festival. The instrument will be featured in a recital on Tuesday, November 8 at 4:00pm by recitalist Alison Luedecke. Ms. Luedecke is the founder of Millennia Consort and hails from Galveston, Texas as a solo concert organist. She has played in France, Canada, Mexico, and Germany. She has been heard numerous times on the syndicated radio show Pipedreams. As an ensemble, musician she has performed with Mainly Mozart Festival Orchestra, Symphony Silicon Valley, and other chamber ensembles. She earned the Doctor of Musical Arts Degree at the Eastman School of Music as a student of David Craighead. We are honored to have our work included among the many fine Aeolian-Skinner organs being showcased in this festival. Below is the brochure with a schedule of events. We look forward to seeing everyone there!
Bach Cantata Vespers
Nov 20
River Forest, IL
- Grace Lutheran Church
- November 20, 2016 — 3:45PM
- Admission: Free Will Offering
- More Info
Gott ist mein König (God is my king)
Organ Resources and Publications
Commitment to customer service is part of our APOBA member pledge. That's why we've included several resources to help you learn about organs and getting your project completed. You'll find publications, FAQs and Resource links at our resources page.View all Resources


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Top Definition
How New Jersians say, "I don't know."
Tom gave me a puzzle to figure out and wouldn't you know it got me by the knockers!
door petersonto 13 maart 2008
Trending Now
Can you define these popular missing words?
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One of nature's greatest spectacles is the array of colors presented during autumn in the mountains.
Over the course of many years, I have spent a lot of time in hospital waiting rooms, hoping for good news and, at the same time, dreading the bad.
"Worrying is just praying for what you don't want to happen," is an often used quote about worrying.
When I was a young sports writer, just beginning an education on the world of sports and the men who made the majors great, I was fascinated with NFL quarterback Kenny Stabler.
My history-loving child has a new fascination - old TV shows.
One insect that is universally loathed is the cockroach.
Sitting in for Ronda this week is her husband, John Tinker... "Tink."
I am deeply envious of those who get a full night's sleep.
Fall is a busy time in the forests and woodlands of North Georgia. Many visitors from metro Atlanta and surrounding areas come to enjoy the annual leaf color displays.
It didn't surprise me it was him. Although such had never crossed my mind, it was, of course, just the kind of thing that he would do.
"Mama, what was your toughest job?" Cole asked one day.
When most people think of dogwood trees, the first thing that comes to mind is usually our native flowering dogwood (Cornus florida). This small tree was a landscape favorite because of its beautiful white flowers and red berries, as well as its easy-to-grow nature.
I have been doing some self-work lately - a byproduct of trying to better myself these last few years.
Take a moment to think back to February earlier this year. What were you doing?
Page 5 of 51
I am going to admit something not too pretty here: I have a hard time with forgiveness.
The wildlife here ranges from sketchy looking squirrels, to bears to deer that are almost as domesticated as dogs.
We were cleaning up the dishes from Sunday dinner when Rodney called me into the living room where he was watching TV.
"He's a little boy," is the logic my husband gives me for just about everything our child does.
As best I can recall - and I've been thinking hard about this - I have only written one fan letter in my life.
The other day an email arrived from a Korean War veteran who started off by saying, "I suppose someone else will get this, add me ...
My favorite season is fall. In fact, I wish it could be fall all year.
In the months before we married, I sought to show Tink the Southern mountains of my raising. On a colorful autumn afternoon, I was driving ...
My child is already making his birthday list, putting a corgi at the top of his list followed by Pokemon cards and DS games.
Trees provide great benefits to our home landscapes. They provide shade, help retain soils and add visual interest. It is important that we take care ...
Page 1 of 1
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Your local store is open for the next 5h, 13m and 31s
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The BrightHouse Wishaw store features an exciting range of the very latest home entertainment, computing, kitchen appliances and home furniture. From televisions to laptops and from fridge freezers to sofas, in store you'll discover an extensive range of products all available on our range of pay weekly and pay monthly finance plans, allowing you to buy now and pay later.
Wishaw is in North Lanarkshire in Scotland, about 15 miles east of Glasgow. The origin of the town's name comes from the Old Scots words for wood, though its precise meaning is unknown. Wishaw includes several surrounding villages such as Overtown and Newmains, as well as smaller areas such as Dimsdale and Greenhead.
The BrightHouse Wishaw store can be found on the Main Street in the centre of town, just down the road from the Old Parish Church. There are bus stops directly outside the store as well as in nearby streets for major local routes, and there is free parking available in the town centre, including at the nearby Wishaw Library. We're also just five minutes' walk from Wishaw railway station down Hill Street.
Once you have completed the online application, you will need to visit one of our stores to select your product and arrange delivery, subject to affordability checks.
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Product Insurance Cover is provided by way of insurance from Caversham Insurance (Malta) Limited. Caversham Insurance (Malta) Limited is authorised by the Malta Financial Services Authority and subject to limited regulation by the Financial Conduct Authority and Prudential Regulation Authority. Details about the extent of our regulation by the Financial Conduct Authority and Prudential Regulation Authority are available from us on request. Caversham Insurance (Malta) Limited operates in the UK through its agent, Caversham Finance Limited (trading as BrightHouse). Caversham Finance Limited trading as BrightHouse, 5 Hercules Way, Leavesden Park, Watford, WD25 7GS. Registered in England 785922.
Caversham Finance Limited is authorised and regulated by the Financial Conduct Authority for consumer credit. It is on the Interim Permission Consumer Credit Register with Reference Number 345103. The Register is available here
BrightHouse reserve the right not to extend credit. Terms and conditions apply. Ask in store for details.
Find out more at http://www.brighthousegroup.co.uk


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Digitize Notes with CamiApp for Android
Productivity Sauce
Among solutions that bridge the digital and analog worlds, CamiApp is by far my favorite one. I stumbled upon CamiApp notebooks in the Tokyu Hands store in Tokyo.
These notebooks are designed for use with the accompanying CamiApp for Android (which, according to the app's licensing info, is based on several open source components). The app lets you easily digitize notes using the Android built-in camera, and it does a good job of straightening and cleaning up the snapped images. You can then neatly organize the processed snaps using tags and descriptions. What's more, each sheet in the CamiApp notebook contains a so-called action marker: a small field consisting of three columns. You can configure the app to automatically attach a specific tag to a note depending on which column or columns are marked.
CamiApp also features simple editing tools for annotating snaps. In addition to that, you can upload the snaps to Evernote and Dropbox directly from the app. CamiApp notebooks are not available outside Japan (I order mine from a Japanese web store that ships goods to Europe), but according to the comments at the app's page, CamiApp works just fine with plain notebooks, too.comments powered by Disqus
Issue 191/2016
Buy this issue as a PDF
Nextcloud Announces Raspberry Pi-Powered Home Cloud Box
Innovative system adds a hard drive and Ubuntu Core to the RPi for an IoT hub.
Linus Torvalds Confirms the Date of the First Linux Release
Linux is two weeks younger than we thought!
End of OpenOffice?
The Apache Software Foundation considers retiring OpenOffice
Adobe Gives New Life to NPAPI Plugin for Linux
Adobe won't kill the plugin in 2017
LinuxCon North America Convenes in Toronto, Canada
Linux Foundation's big event celebrates the 25th anniversary of Linux
Linux Turns 25
Linux has evolved from "won't be a professional" project to one of the most professional software projects in the history of computers.
Mirantis Joins Hands with SUSE To Offer RHEL Support; Red Hat Not Happy
Competitors get in the game with RHEL without Red Hat
Linux on Windows 10 Poses a Security Risk
Security researchers have already notified Microsoft; some fixes are available
Mirantis to Refactor OpenStack Fuel for Kubernetes
The company is collaborating with Google and Intel to use Kubernetes as an engine for Fuel
Canonical Joins Document Foundation Advisory Board
The upcoming release of LibreOffice will be available as a snap package