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If you've worked with video in earlier versions of Photoshop Extended, you probably discovered that there were not many file types you could open. Previously, if it worked in QuickTime, it worked inside of Photoshop. Well now, the core media engine has been updated to use similar technology that's found in Adobe Premiere Pro. What this really means is that a wide range of formats are now supported. We can of course continue to use the MOV or QuickTime architecture, which has been supported for a long time; you'll also find support for high-end still image sequence formats like Cineon on DPX. There is support for the AVI format, which is popular in Windows workflows and we can also use native camera formats like a MXF; the Panasonic P2 format. You'll be able work with files like VOB, MPEG-2 and MPEG-4 file formats, as well as mobile formats like 3GPP and Flash Video.
A good way to tell if it's going to work inside of Photoshop is to just to go to the Mini Bridge panel; you'll need to have Adobe Bridge running in the background. This allows you to go ahead and look at individual clips and you can see them. If they appear inside of Bridge, you will have the ability to simply bring those into Photoshop and they'll open up into a timeline. You could then press Play and see the clip playback in real time. That's looking good, I'll press Stop and it's clear here that this particular format is fully supported.
The easiest thing I could tell you is to simply try. By keeping Adobe Photoshop up-to-date you will often find that file formats are going to be increasingly compatible. If you can browse and see it in Bridge, just try dragging it in, chances are it'll work. You'll also find support for many audio formats, and of course, the wide range of still image file formats that Photoshop could always open.
- Understanding the video file formats supported in Photoshop
- Controlling playback in the Timeline
- Building a sequence
- Organizing and editing A-roll and B-roll footage
- Adding transitions
- Adjusting volume
- Adding music
- Color balancing a shot
- Adjusting contrast
- Adding a lower-third graphic
- Animating text
- Exporting to H.264 or QuickTime


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words_dora williams. illustration_claudia fernandes. Hurricanes' football of the 80's went hand in hand with two words: attitude and winning. »
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Sons of Anarchy Season 7 Episode 3 "Playing With Monsters" Sons of Anarchy aired its third episode of the final »
The Pérez Art Museum Miami (PAMM) just got several shades brighter. Friday, Sept. 19, PAMM unveiled a new exhibition created by »
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For those who have worried about Apple, rest assured that the problems are all solved. This undoubtedly is the reason the stock jumped from the red into the green this morning:
New iPhone App, Panty Combo Lets You 'Touch' People Remotely From iPhone
Kinky just got a little boost today. Durex, yes that Durex, has just released a video showing off its new Fundawear. Long story short, you can fondle your lovers love-parts remotely from an iPhone without ever having to be in the same room, city, or country. The underwear is available...
From macgasm
Wishful thinking?
Sentiment: Strong Sell


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FedEx expects delivery volume to surge on Mondays
Retailers' holiday promotions and a shift in consumer buying habits generates heavy demand for Monday deliveries by FedEx.
FedEx expects delivery volume to surge on Mondays
Retailers' holiday promotions and a shift in consumer buying habits generates heavy demand for Monday deliveries by FedEx.
Nordstrom names a new president for its e-commerce site
Ken Worzel becomes president of Nordstrom.com as the retailer shakes up executive duties.
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Mike Kirschner, senior vice president of e-commerce for Office Depot prior to its merger with OfficeMax, is in the running for the position.
Office Depot Inc.'s new CEO Roland Smith has only been on the job about a month, but he's wasting no time in getting down to business. Office Depot, which recently merged with rival chain OfficeMax, announced a number of changes to its executive ranks today.
Among those, the company is looking to name an executive vice president of e-commerce. This person will head up all North American e-commerce sites, including those geared for business clients and consumers, and "set strategic direction to grow profitable sales while developing an omnichannel shopping experience aimed at increasing share of wallet," the merchant says.
Mike Kirschner, who was senior vice president at Office Depot before the merger, is in the running for the role. Meanwhile, he will serve as interim head of e-commerce.
"Since I joined the Company last month, my priorities have been to name a headquarters location and select a leadership team that incorporates the best talent from both companies and also adds fresh perspective from the outside," Smith says. "The Company's new organizational structure focuses on accountability and streamlined decision making. I believe this approach provides the best foundation to execute the merger synergies and transformation strategy for long-term growth."
Office Depot, which announced last week it will be headquartered in Boca Raton, FL, where Office Depot had been based, also began an external search for a president of its North American business. The new president will manage retail, sales, e-commerce, marketing and supply chain. Steve Schmidt is the new president of the retailer's international business and will be relocating to Europe. Schmidt served the same role at Office Depot prior to the merger.
Other appointments include Tim Rea, the new executive vice president of marketing, who previously served as senior vice president of brand strategy at Office Depot. Todd Hale is now senior vice president and global chief information officer, and he will oversee I.T. projects. He was North American CIO prior to the merger.
Office Depot also wants to name a chief strategy and innovation officer, a new position, who will lead efforts to develop new business initiatives. The retailer did not elaborate on the specifics of those initiatives.
Roland Smith joined Office Depot as Chairman and CEO last month following its merger with OfficeMax. The CEOs of the previous two companies, Neil Austrian of Office Depot and Ravi Saligram of OfficeMax, resigned at that time.
The new company had combined 2012 web sales of $7.26 billion, Internet Retailer estimates in its Top 500 Guide. By comparison, the merged company's main rival, Staples Inc., No. 2 in that guide after Amazon.com Inc., generated 2012 web sales of $10.3 billion.
The combined company will have had total revenue of $17 billion for the year ended Sept. 30, Office Depot says. Office Depot holds the No. 7 spot in the Top 500, while OfficeMax ranks at No. 11.
Images, tags and mobile performance are among the key areas to focus on in the ...
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Many e-retailers focus on conversion rate, but here are four less-obvious ways to analyze your ...
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Online retail is hard, grocery retail is really hard, so online grocery is, of course, really, really hard."


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Marion Bell was a highly acclaimed light opera singer of the 1940s. Though she spent her entire career on-stage (but for two film appearances), it was MGM filmmaker Robert Z. Leonard who discovered her singing at age 15 and was so impressed that he decided to oversee her training and career. He signed her to MGM and she was sent on a vaudeville tour with the Marx Brothers. She made her film debut (it was uncredited) in A Night at the Opera (1935) and can be seen shoving her way through a crowd to get to the phone so she could call Aunt Minnie in the famous stateroom scene. Bell made her second and final film appearance as a singer in Ziegfeld Follies (1946). Bell was most active during the '40s, and after playing Fiona in the stage musical Brigadoon (1947), she married the show's librettist, Alan Jay Lerner. By the '50s, Bell's health began to fail and she was forced to slow down considerably, though she did continue touring. Bell died on December 14, 1997, of heart failure.
~ Sandra Brennan, All Movie Guide


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Cleveland Gang Rape Story: District Attorney Mike Little, Only One Authorized to Talk, Takes Week's Vacation from the Office
When Liberty County's District Attorney Mike Little gagged anyone involved in the Cleveland gang rape case -- in which an 11-year-old girl was allegedly raped brutally by multiple men and boys -- from talking, you'd think he'd hang around as the singular voice for his muted county. Instead, it appears he's gone on vacation.
Today, as new information surfaced via the Houston Chronicle, the D.A. is nowhere to be found. We at the Houston Press called up Little, the only one authorized to talk to the media about one of the biggest cases in Cleveland's history. Cathy McClusky, the secretary, said that Little has been out the entire week and she's "not certain" when he'll return.
Little picked a pretty bad time to hang up the gone fishin' sign.
It turns out the alleged rapes didn't take place just one day over Thanksgiving break. Rather, they took place at least four times over a three-month period, court records obtained by the Chronicle reveal.
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This means more substantial charges for those who participated in the rape on more than one date. If found guilty, those charged with continuous sexual abuse of a child could serve a minimum of 25 years. Being convicted of a single incident guarantees at least five years.
Additionally, the cell phones of three of the men charged with continuous sexual assault -- Timothy Daray Ellis, 19; Jared Len Cruse, 18; and Isaiah Rashad Ross, 21 -- were confiscated and are being analyzed for deleted pictures, texts and videos. If pornographic pictures of the victim are discovered, they could be charged with possessing child pornography with intent to distribute. This recovered information could easily result in the arrests of more suspects.
As for who released the new information, well, McClusky told us we'd just have to speak with Mr. Little about that -- whenever he chooses to return.
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The Municipality of Rapid City, SDRapid City, South Dakota, located in Pennington, has a population of 69,079. The population has increased 12% since 2000. The average temperature in January is 22° and 70° in July. The community includes 29,260 households, with an average household size of 2 people. Rapid City households are made up of 34,128 men and 34,950 women. In Rapid City, 40% of those who call the area home are married and of the 29,260 households, 61% are families with two or more people living in the home. About 30% of families have one or more children living at home. The median age of Rapid City residents is 36 years. The city is home to many Casper Ghosts (R) sports fans. With a CO risk index of 95, amidst growing concerns about environmental health, we suggest protecting your health with a Protection 1 carbon monoxide alarm.
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Rapid City South Dakota Community Stats
County: Pennington
Median Age: 36 Years
Median Commute: 13 Min
Educational Climate: 4*
Recycling Likelihood: 91**
Sales Tax: 6%
Closest Airport:
Rapid City Regional
Rapid City Regional
Closest College:
National American University
National American University
Closest Jr. College:
Western Dakota Tech Inst
Western Dakota Tech Inst
Population: 69,079
Population Density:
1,189 Persons Per Square Mile
1,189 Persons Per Square Mile
Population Change Since 2000: 12%
Median Household Income: $45,768
Annual Residential Turnover: 25%
Median Years in Residence:
2 Years
2 Years
Median Home Sales Price: $0
Change Avg. Household Income Since 2000: 27%
*Scale from 1-5 **Index where 100 is the national average
Local Rapid City Security and Personal Crime Risks
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National vs. Local Crime Index (95)
Personal Crime Risk Index (67)
Life Safety and Health Security Risks in and around Rapid City
The following data includes the local score compared to the national average of 100.
Storm Risk
CO Risk
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5 Reviews
I served this with an Easter turkey meal to my family and it was AWESOME!! Even my kids loved it. I have never served asparagus before and didn't know the best way to cook it, so this website was very helpful. So easy to make in the microwave and the shrimp wasn't tough at all. I omitted the peppers (just can't stand them) but used a whole lemon rind and just served it as a vegetable dish- no rice. FABULOUS!!
WOW this was the best Lemon sauce I have ever had!!! We LOVED this dish!! I made this for 4 people so I made quite a few changes. I used 2 pounds of shrimp, 1 pound fresh asperagus, 3 cloves garlic, 4 Tbs soy sauce, 2 Tbs lemon rind, 3 Tbs lemon juice, 3 tsp cornstarch. I will use this sauce alot in the future for shrimp and chicken. Thanks for posting!!!!
Was good. I used extra tripled the lemon, since I love the flavor and served with sticky rice.
This was tasty, but I think it could use more lemon flavor. Next time we'll use double the lemon rind and juice. Otherwise, a very nice dish!
hubby wasnt too fond of this one


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Jump to content
Posted by Internet.Unknown
on 03 July 2016 - 09:05 AM
Posted by Internet.Unknown
on 03 July 2016 - 09:03 AM
So is Frk.
Posted by Internet.Unknown
on 02 July 2016 - 09:19 PM
The irony of Internet Unknown posting that amuses me.
Posted by Internet.Unknown
on 02 July 2016 - 05:20 PM
What a joke of signing Kenny needs to go freaking idiot why are we signing D's retreads that's why we will never win anything what about Jimmy's contract no one is gonna take that abomination
Posted by Internet.Unknown
on 02 July 2016 - 10:13 AM
I'm just someone who hates players that can't do anything but fight.
But...but...but... I thought only the "all-stars" were responsible for winning?
I sense that shocky will never truly understand just how wrong he is on this subject.
Posted by Internet.Unknown
on 01 July 2016 - 10:07 PM
No s*** if we drafted a top 3 player they'd be playing but just because we don't doesn't mean every prospect has to wait 4 years in the minors .... Your telling me Tatar wasn't ready after 3 years In Grand Rapids?nyquist? Don't tell me they weren't ready
It's quite obvious Detroit has always preferred the veterans over younger talent ... Just look what they did now , they signed ott who hasn't been relevant in 7 years , signed vanek on the decline after they said mantha would be given every opportunity to make this team ( we both know that's not happening especially with Miller AND helm being resigned as well )
Ouellet is another kid who could of played last season but waited another year cause we give wastes like Ericsson longterm deals
First? The way this team is headed that can end up being a top 5 pick , no way we can touch it now
Posted by Internet.Unknown
on 01 July 2016 - 07:51 PM
Too young lmao I wish f*** I remember all those scraps and more
Those 4 you named were hall of famers and pretty sure Zetterberg and datsyuk started at 21-23 so I wouldn't compare them , no ones saying Tatar and nyquist are superstars or mantha will be a hall of famer the fact is we tend to always play veterans more than some kids who can actually play cause we've just always preferred playing the vet over the kid
Posted by Internet.Unknown
on 01 July 2016 - 05:02 PM
Pretty much our lineup will look like this:
Larkin - Z - Abdelkader
Nyquist - Nielsen - Vanek
Helm - She - Tatar
Miller - LG - Ott
AA and Mantha = Grand Rapids
DeKe - Kronwall
Errorson - Green
Smith - Marchenko
Posted by Internet.Unknown
on 01 July 2016 - 05:00 PM
Posted by Internet.Unknown
on 01 July 2016 - 04:44 PM
Assuming it will look something like this
Zetterberg nielson abdelkader
Athanasiou Larkin vanek
Helm sheahan Tatar/nyquist
Miller glendening ott
Or switch vanek with Tatar/nyquist
Knowing Ken holland and his bulls*** overripe Anthony mantha wil be in Grand Rapids regardless of anything he says to the media unless he's stupid enough to trade him
That will leave
Jurco pulkkinen frk nyquist/Tatar and I'm assuming jurco/frk will be 13th forward
Pulkkinen is gone ... Frk or jurco as well , I just hope none are through waivers and mantha is in Grand Rapids 100% unless he's dealt or Tatar and nyquist are both dealt which seems unlikely
So seems the wings keep on giving nothing to the kids ... Just the way holland loves it
Posted by Internet.Unknown
on 01 July 2016 - 01:23 PM
Eriksson and okposo didn't want to come here. Is there anyway to sticky this so people understand Holland just can't sign anyone, there is 29 other teams.
6 million apparently gets you a 40-50 point 2 way center.
Sent from my iPhone using Tapatalk
Posted by Internet.Unknown
on 01 July 2016 - 12:43 PM
I don't think Yzerman would have been savior either. This team has been declining for 6 years and we need to stop duct taping this team together for the sake of a meaningless streak. The problem is Ilitch wants a competitive team when the pizzarena opens up so I don't see us blowing things up for another couple of years.
Posted by Internet.Unknown
on 01 July 2016 - 12:25 PM
I've heard that a lot but where is a proof of that? Wings are risking to turn into the Leafs or Canucks who for the longest time refused to rebuild. Vancouver still doesn't see the Eriksson signing.
If the order is indeed from Mr I than you are right Holland must follow the orders.
If they bring in some bought out guys in the hope they'll regain their form this team might as well get used to first round exits for a long time.
Posted by Internet.Unknown
on 01 July 2016 - 12:16 PM
I really hope the Red Wings birthday presents to me aren't just a Nielsen signing and resigning of Helm and Marchenko.
Posted by Internet.Unknown
on 01 July 2016 - 12:13 PM
Community Forum Software by IP.BoardLicensed to: LetsGoWings.com


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your welcome!! ^^
That Pixel (Otaku Legend) | Posted 10/11/12 | Reply
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➸Anti-Theft Ninja➸ (Otaku Eternal) | Posted 10/11/12 | Reply
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Sep 11, 2001
|Filing date
|May 21, 1999
|Priority date
|May 22, 1998
|Fee status
|Publication number
|Rima Kaddurah-Daouk
|Original Assignee
|Rima Kaddurah-Daouk
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (6), Non-Patent Citations (10), Referenced by (15), Classifications (4), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims priority to U.S. Provisional Patent Application Ser. No. 60/086,585 filed on May 22, 1998, the entire contents of which are hereby expressly incorporated by reference. The entire contents of each of U.S. Ser. No. 07/610,418, filed Nov. 7, 1990, U.S. Ser. No. 07/467,147 filed Jan. 18, 1990, U.S. Ser. No. 07/344,963 filed Apr. 28, 1989, U.S. Ser. No. 07/310,773 filed Feb. 14, 1989, and U.S. Ser. No. 07/812,561 are hereby also expressly incorporated by reference. The entire contents of each of U.S. Provisional Patent Application Ser. No. 60/086,504 filed on May 22, 1998 and U.S. Patent Application Ser. No. (yet to be assigned) entitled "Use of Aminoguanidine or Aminoguanidine Analogs for the Treatment of Diseases of the Nervous System," filed on even date herewith, also are hereby expressly incorporated herein by reference.
Worldwide, cancer is a leading cause of death. Presently, few cures exist for treating the various types of cancer. Among the possible cures that do exist include the application of tumor-inhibiting compounds (chemotherapy), radiation therapy, and bone-marrow transplants.
Transformation of cells results in changes in their growth characteristics and can cause them to form tumors in animals into whom they are introduced. For example, transformation of adherent cells can be associated with certain alterations such as changes in growth control, cell morphology, membrane characteristics, protein secretion and gene expression. Although transformation can occur spontaneously, it can be caused by a chemical or irradiation or may result from infection by a tumor virus. Little is known about the underlying molecular events. One type of RNA viruses (the retroviruses) and many different types of DNA viruses can act to transform cells and collectively are referred to as tumor viruses. In the case of tumor viruses, it is clear that the virus does not itself carry all of the genes necessary to produce the phenotypic changes characteristic of infected cells. Tumor viruses may act through a gene or genes in their genome (oncogenes) which, in some way, influence or induce target cell genes. The induced target cell genes, in turn, act to carry out the changes observed in transformed cells. There are at least three major classes of transforming DNA viruses: adenoviruses, which have two groups of oncogenes, ElA and ElB, which act together to produce transformation; papovaviruses, which synthesize proteins, called T antigens, which may work together to transform cells; and herpes viruses, for which no oncogene has been identified as yet.
Although considerable effort has been expended in identifying transforming genes or oncogenes and, in some cases, has also resulted in identification of their protein products, very little is known about the cellular mechanisms affected in the transformation process. There is a consensus that these oncogenes perturb cell growth by modifying the expression or activity of key growth related genes. It would be very helpful to have a better understanding of how transformation occurs, particularly if the biochemical pathways affected can be identified. Such knowledge would make it possible to design compounds which can interfere with or counter the effects of the transforming signals and, thus, are useful in preventing transformation or minimizing the extent to which it occurs, once begun, and, thus, to reduce effects on individuals in whom it occurs.
Prior art chemotherapy treatments typically include the application of chemotherapeutic agents to a patient in selected dosages to achieve and maintain a therapeutically effective level of the agents in the patient. However, most known chemotherapeutic agents used for the treatment of cancer display significant side effects. Thus, a drawback of typical chemotherapy treatments is that the compounds employed are non-specific in their activity and accumulate to toxic levels, and hence kill rapidly proliferating normal cells, as well as tumor cells.
Creatine Kinase (CK) is a purine metabolic enzyme that is intimately involved in the maintenance of ATP at various cites of cellular work. Typically, increased levels of CK are associated with cell transformation, and are thus used as markers to identify the same.
The creatine kinase (CK; EC 220.127.116.11) isozymes and their substrates, creatine and creatine phosphate (Cr-P), are believed to play a pivotal role in energy transduction in tissues with large fluctuating energy demands such as skeletal muscle heart and brain. The enzymes catalyze reversibly the transfer of the γ-phosphoryl group of ATP to creatine (Cr) to yield creatine phosphate (Cr-P) and ADP. The CK isozymes include three cytosolic forms, brain (CK-BB), muscle (CK-MM) and heart (CK-MB), as well as two mitochondrial forms, ubiquitous and sarcomeric.
A variety of important functions have been associated with the creatine kinase/creatine phosphate system (CK/CrP). Walliman et al., Biochem. J., 281: 21-40 (1992). The Cr-P molecule seems to serve as an energy carrier connecting sites of energy production with sites of energy utilization via the subcellularly compartmentalized CK isoenzymes. A main function of the system is to provide appropriate local ATP/ADP ratios at subcellular sites where CK is functionally coupled to ATP consuming enzymes or processes. Another important function is to prevent increases in intracellular ADP levels during periods of cellular work, thus avoiding inactivation of cellular ATPases and net loss of adenine nucleotides.
It is now known that this enzyme system plays an important part in the metabolic events that take place during cell transformation. First, several studies of tumor cells have reported elevated levels of the brain isozyme of CK in several human tumors and in the serum of cancer patients. (see Ishiguro et al., Cancer, 65: 2014-2019 (1990); Gazdar et al., Cancer Research, 41: 2773-2777 (1981); Feld et al., Clin. Chem., 23: 1930-1932 (1977); Homburger et al., Clin. Chem., 26: 1821-1824 (1980); and Lillie et al., Cancer Res., 53: 1-7 (1993). Second, the CK-BB gene is induced by the transforming domains of the adenovirus Ela oncogene (Kaddurah-Daouk et al., Mol. Cell. Biol., 10: 1476-1483 (1990). Third, it has been noted that creatine is important for the growth of Ehrlich ascites tumors (Ohira et al., Biochem. Biophys. Acta, 1097: 117-122 (1991) and Becker S. and Schneider F., Bio. Chem. Hoppe-Seyler, 370: 357-365 (1989)).
The present invention is based, at least in part, on the discovery that aminoguanidine compounds inhibit undesirable cell growth, e.g. inappropriate cell growth resulting in undesirable benign conditions or tumor growth. The present invention provides for the use of aminoguanidine compounds for prophylactic and/or therapeutic treatments of undesirable cell growth. The present invention provides methods of using aminoguanidine compounds to inhibit the growth of undesirable cell growth in a subject. The present invention provides a method for inhibiting undesirable cell growth in a subject by administering to a subject an effective amount of aminoguanidine compound.
The present invention further pertains to compositions for inhibiting undesirable cell growth, e.g. tumor growth, in a subject. The copositions of the present invention include an effective amount of the aminoguanidine compound in a pharmaceutically acceptable carrier. Other aspects of the invention include packaged aminoguanidine compounds. The packaged compounds also include instructions for using the aminoguanidine compound for inhibiting undesirable cell growth in a patient or instructions for using the compound, in selected quantities, in a pharmaceutically acceptable carrier.
The methods and compositions of the present invention can be used for in vivo therapeutic purposes or can be used ex vivo for purging bone marrow. The bone marrow can be purged with the aminoguanidine compound and then placed back into the same subject or a different subject in its purged form. The methods and compositions of this invention also can be used in ex vivo screening assays for tissue or cells removed during surgery to determine whether the tissue or cells are cancerous or benign.
The features and other details of the invention will now be more particularly described and pointed out in the claims. It will be understood that the particular embodiments of the invention are shown by way of illustration and not as limitations of the invention. The principle features of this invention can be employed in various embodiments without departing from the scope of the invention.
The present invention pertains to a method of inhibiting undesirable cell growth in a subject. The method involves the administration of an effective amount of an aminoguanidine compound to the subject such that growth of the undesirable cell(s) is inhibited.
The term "administering" is intended to include routes of administration which allow the aminoguanidine compound to perform its intended function of inhibiting undesirable cell growth. Examples of routes of administration which can be used include injection (subcutaneous, intravenous, parenterally, intraperitoneally, intrathecal, etc.), oral, inhalation, and transdermal. The injection can be bolus injections or can be continuous infusion. Depending on the route of administration, the aminoguanidine compound or inhibitory agent can be coated with or disposed in a selected material to protect it from natural conditions which may detrimentally effect its ability to perform its intended function. The aminoguanidine compound can be administered alone, or in conjunction with either an inhibitory agent or with a pharmaceutically acceptable carrier, or both. Further the aminoguanidine compound can be administered as a mixture of aminoguanidine compounds, which also can be coadministered with at least one inhibitory agent, or pharmaceutically acceptable carrier, or both. The aminoguanidine compound can be administered prior to the administration of the inhibitory agent, simultaneously with the inhibitory agent, or after the administration of the inhibitory agent. The aminoguanidine compound also can be administered as a prodrug which is converted to its active form in vivo.
Compounds which are particularly effective for this purpose include aminoguanidine, aminoguanidines, diaminoguanidine, diaminoguanidines and analogs thereof which are described in detail below. The term "aminoguanidine compounds" will be used herein to include aminoguanidines and diaminoguanidines, such as aminoguanidine phosphate, and compounds which are structurally similar to aminoguanidine or aminoguanidine phosphate, and analogs of aminoguanidine and aminoguanidine phosphate.
The term "aminoguanidine compounds" also includes compounds which "mimic" the activity of aminoguanidine and diaminoguanidine, such as aminoguanidine, aminoguanidine phosphate or aminoguanidine analogs, i.e., compounds which inhibit or modulate the creatine kinase system. The term "aminoguanidine" is intended not to include guanidine. The term "mimics" is intended to include compounds which may not be structurally similar to aminoguanidine or diaminoguanidine but mimic the therapeutic activity of these compounds, such as aminoguanidine, aminoguanidine phosphate or structurally similar compounds. The term "inhibitors of creatine kinase system" are compounds which inhibit the activity of the creatine kinase enzyme, molecules that inhibit the creatine transporter or molecules that inhibit the binding of the enzyme to other structural proteins or enzymes or lipids.
The term "modulators of the creatine kinase system" are compounds which modulate the activity of the enzyme, or the activity of the transporter of creatine or the ability of other proteins or enzymes or lipids to interact with the system. The term "aminoguanidine analog" is intended to include compounds which are structurally similar to aminoguanidine or diaminoguanidine compounds such as aminoguanidine phosphate compounds which are art recognized as being analogs of aminoguanidine or aminoguanidine phosphate, and/or compounds which share the same or similar function as aminoguanidine or aminoguanidine phosphate.
The language "pharmaceutically acceptable carrier" is intended to include substances capable of being coadministered with the aminoguanidine compound(s) and/or the inhibitory agent(s), and which allows both to perform their intended function of inhibiting undesirable cell growth in a subject. Examples of such carriers include solutions, solvents, dispersion media, delay agents, emulsions and the like. The use of such media for pharmaceutically active substances are well known in the art. Any other conventional carrier suitable for use with the aminoguanidine compound and/or with the inhibitory agent(s) also fall within the scope of the present invention.
The language "effective amount" of the aminoguanidine compound is that amount necessary or sufficient to inhibit the undesirable cell growth, e.g. prevent the undesirable cell growth, or reduce the size of a pre-existing benign cell mass or malignant tumor in the subject. The effective amount can vary depending on such factors as the type of cell growth being treated or inhibited. the type of inhibitory agent(s) employed, the particular creatine compound, the size of the subject, or the severity of the undesirable cell growth or tumor. For example, the choice of each of the agent (aminoguanidine compound) can affect what constitutes an "effective amount". One of ordinary skill in the art would be able to study the aforementioned factors and make the determination regarding the effective amount of the aminoguanidine compound and inhibitory agent, if present, without undue experimentation. An in vitro assay can be used to determine an "effective amount" of the aminoguanidine compound. The ordinarily skilled artisan would select an appropriate amount of the agent for use in the aforementioned in vitro assay. The cell survival fraction can be used to determine whether the selected amount was an "effective amount". For example, the selected amount used within the assay preferably should result in a killing of at least 50% of the cells, more preferably 75%, and most preferably at least 95%.
The regimen of administration also can affect what constitutes an effective amount. The aminoguanidine compound can be administered to the subject prior to, simultaneously with, or after the administration of other inhibitory agent(s). Further, several divided dosages, as well as staggered dosages, can be administered daily or sequentially, or the dose can be continuously infused. Further, the dosages of the compound and the agent(s) can be proportionally increased or decreased as indicated by the exigencies of the therapeutic situation.
Aminoguanidine compounds of this invention are those encompassed by the general formula I
a) R1 through R16, if present, are selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, and alkoxyl;
b) J is either
c) Q is either
d) T, if present, is R12 or NR13R14;
e) Y is an alkylene, alkenylene, alkynylene or an alkoxylene;
f) Z is selected from the group consisting of
wherein B1-B4 are each independently selected from hydrogen and OX4 and X1-X4 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl and pharmaceutically acceptable salts; and
wherein Y and Q or N and Q can form a ring structure.
The alkylene, alkenylene, alkynylene, alkyl, alkenyl and alkynyl groups (hereinafter hydrocarbon groups) may have straight or branched chains. The unsaturated groups may have a single site of unsaturation or a plurality of sites of unsaturation. The hydrocarbon groups preferably have up to about ten carbons, more preferably up to about six carbons, and most preferably up to about three carbons. A hydrocarbon group having three carbon atoms or less is considered to be a lower hydrocarbon group. For example, an alkyl group having three carbon atoms or less is a lower alkyl. Examples of lower hydrocarbon groups which may be used in the present invention include methyl, methylene, ethyl, ethylene, ethenyl, ethenylene, ethynl, ethynylene, propyl, propylene, propenyl, propenylene, propynyl, and propynylene. Examples of higher hydrocarbon groups (from four to about ten carbons) include butyl, t-butyl, butenyl, butenylene, and butynyl, butynylene, nonyl, nonylene, nonenyl, nonenylene, nonynyl, and nonynylene.
The alkoxy, haloalkyl, alkoxyene, and haloalkylene groups (hereinafter substituted hydrocarbon groups) are alkyl or alkylene groups substituted with one or more oxygen or halogen atoms. The alkoxy and haloalkyl groups also may be straight or branched chain and preferably are made up of up to about ten atoms (including carbon, oxygen or halogen), preferably up to about six atoms, and most preferably up to about three atoms. The term halogen is art-recognized and includes chlorine, fluorine, bromine, and iodine. Examples of substituted hydrocarbon groups which are useful within this invention are similar to hydrocarbon groups set forth above except for the incorporation of oxygen(s) or halogen(s) into the groups.
The language "pharmaceutically acceptable salt" (as a possibility for "X" in formula (I) and as it pertains to aminoguanidine compound salts) is intended to include pharmaceutically acceptable salts capable of being solvated under physiological conditions. Examples of such salts include sodium, e.g. disodium, potassium, e.g. dipotassium, and hemisulfate. The term is further intended to include lower hydrocarbon groups capable of being solvated under physiological conditions, i.e. alkyl esters, e.g. methyl, ethyl and propyl esters.
The nitrogen of formula I and Q or Q and Y can form a ring. The ring can be a hydrocarbon ring or a hetero ring containing atoms such as O, N or S. The ring structure further can be a single ring or alternatively can be a fused ring system. The preferred ring structures are single rings having five, six or seven ring members and most preferably five membered rings such as those present in cycloaminoguanidine- or carboaminoguanidine-like compounds, e.g.,
In one aspect of the invention, aminoguanidine compounds include
wherein R1-R16 and Y are as defined above. Optionally R2 and R5 or R2 and R6 or R2 and R8, together, can form a ring.
In another aspect of the invention, aminoguanidine compounds include
wherein R1-R16 are as described above. Optionally R2 and R5 or R2 and R6 or R2 and R8, together, can form a ring.
Preferred aminoguanidine compounds of the invention are
Aminoguanidine, aminoguanidine phosphate and many aminoguanidine analogs, and competitive inhibitors are commercially available and/or have been previously synthesized and are known in the literature.
Synthesis of guanidinoalkylcarboxylic acids can be accomplished by condensation of substituted or unsubstituted amino acid with a substituted or unsubstituted cyanamide. For example, 3-guanidinopropionic acid is commercially available and can be prepared as follows:
Preparation of [1-(hydrazinoiminomethyl)hydrazino]-acetic acids of the invention can be accomplished by the following synthetic procedure:
wherein R1-R11 are as defined above. For example, preparation of (CAS # 179474-69-2) can be accomplished by the following synthetic procedure:
wherein preparation of
can be accomplished by the following reactions sequence:
[2-(aminoiminomethyl)hydrazino]-acetic acids of the invention can be prepared known synthetic procedures. For example preparation of (CAS # 179474-55-6) can be accomplished by the following synthetic procedure:
[2-(hydrazinoiminomethyl)hydrazino]-acetic acids of the invention can be prepared known synthetic procedures. For example preparation of (CAS # 179474-62-5) can be accomplished by the following synthetic procedure:
N-(hydrazinoiminomethyl)-glycines of the invention can be prepared known synthetic procedures. For example preparation of (CAS # 17901-84-7) can be accomplished by the following synthetic procedure:
N-(hydrazinohydrazinomethyl)-glycines of the invention can be prepared known synthetic procedures. For example preparation of (CAS # 179474-61-4) can be accomplished by the following synthetic procedure:
wherein preparation of
can be accomplished by the following sequence:
Additionally, analogs of aminoguanidine may be synthesized using conventional techniques (See for example Larson, Scott D. et al. PCT Int. Appl. WO 96 16,031, the contents of which are hereby expressly incorporated by reference). For example, aminoguanidine can be used as the starting material for synthesizing at least some of the analogs encompassed by formula I. Appropriate synthesis reagents, e.g. alkylating, alkenylating or alkynylating agents may be used to attach the respective groups to target sites. Alternatively, reagents capable of inserting spacer groups may be used to alter the aminoguanidine structure. Sites other than the target site are protected using conventional protecting groups while the desired sites are being targeted by synthetic reagents.
Some specific examples of aminoguanidine compounds of the present invention include cycloaminoguanidine, cycloaminoguanidine phosphate, aminoguanidine, aminoguanidine phosphate (phosphoaminoguanidine), homocycloguanidine and homocycloguanidine phosphate. Cycloaminoguanidine is an essentially planar cyclic analog of aminoguanidine. Although cycloaminoguanidine is structurally similar to aminoguanidine, the two compounds are believed to be distinguishable both kinetically and thermodynamically.
The phosphorylated compound P-cycloaminoguanidine is structurally similar to phosphoaminoguanidine; however, the phosphorous-nitrogen (P—N) bond of cycloaminoguanidine phosphate is believed to be more stable than that of phosphoaminoguanidine. Aminoguanidine compounds which can act as substrates for creatine kinase are at least some of the compounds which are intended to be part of this invention. Examples of such aminoguanidine and diaminoguanidine compounds are included in Table 1.
Aminoguanidine Analogs
Salts of the products may be exchanged to other salts using standard protocols. The enzymatic synthesis utilizes the creatine kinase enzyme, which is commercially available, to phosphorylate the aminoguanidine compounds. ATP is required by creatine kinase for phosphorylation, hence it needs to be continuously replenished to drive the reaction forward. It is necessary to couple the creatine kinase reaction to another reaction that generates ATP to drive it forward. The purity of the resulting compounds can be confirmed using known analytical techniques including 1H NMR, 13C NMR Spectra, Thin layer chromatography, HPLC and elemental analysis.
The aminoguanidine compounds of this invention preferably possess inherent characteristics enhancing their ability to perform their intended function of inhibiting tumor growth. For example, the aminoguanidine compounds preferably have a solubility which allows them to be delivered in vivo and/or are capable of acting as substrates for aminoguanidine kinase. Some examples of aminoguanidine compounds of the present invention are set forth below in Table 1.
The term "subject" is intended to include mammals having undesirable cell growth, e.g. tumors, or which are susceptible to undesirable cell growth, e.g. tumors. Examples of such subjects include humans, dogs, cats, pigs, cows, horses, rats, and mice.
The language "hyperplastic inhibitory agent" is intended to include agents that inhibit the growth of proliferating cells or tissue wherein the growth of such cells or tissues is undesirable. For example, the inhibition can be of the growth of malignant cells such as in neoplasms or benign cells such as in tissues where the growth is inappropriate. Examples of the types of agents which can be used include chemotherapeutic agents, radiation therapy treatments and associated radioactive compounds and methods, and immunotoxins.
The language "chemotherapeutic agent" is intended to include chemical reagents which inhibit the growth of proliferating cells or tissues wherein the growth of such cells or tissues is undesirable. Chemotherapeutic agents are well known in the art (see e.g., Gilman A. G., et al., The Pharmacological Basis of Therapeutics, 8th Ed., Sec 12:1202-1263 (1990)), and are typically used to treat neoplastic diseases. The chemotherapeutic agents generally employed in chemotherapy treatments are listed below in Table 2.
Nitrogen Mustards
Mechlorethamine (HN2)
Melphalan (L-sarcolysin)
and Methylmelamines
Alkyl Sulfonates
Carmustine (BCNU)
Lomustine (CCNU)
Semustine (methyl-CCNU)
Decarbazine (DTIC;
Folic Acid
(′5-fluorouracil; 5-FU)
Floxuridine (fluorode-oxyuridine;
Cytarabine (cytosine
Purine Analogs
and Related
(6-thioguanine; TG)
Pentostatin (2′ - deoxycoformycin)
Vinca Alkaloids
Vinblastin (VLB)
9-amino-campotothecin CPT-11
(actinomycin D)
Mitomycin (mitomycin C)
Interfon alfa
interleukin 2
Substituted Urea
Methyl Hydraxzine
Mitotane (o,p′-DDD)
Megestrol acetate
Ethinyl estradiol
Testosterone propionate
hormone analog
The language "radiation therapy" is intended to include the application of a genetically and somatically safe level of x-rays, both localized and non-localized, to a subject to inhibit, reduce, or prevent symptoms or conditions associated with undesirable cell growth. The term x-rays is intended to include clinically acceptable radioactive elements and isotopes thereof, as well as the radioactive emissions therefrom. Examples of the types of emissions include alpha rays, beta rays including hard betas, high energy electrons, and gamma rays. Radiation therapy is well known in the art (see e.g., Fishbach, F., Laboratory Diagnostic Tests, 3rd Ed., Ch. 10: 581-644 (1988)), and is typically used to treat neoplastic diseases.
The term "immunotoxins" includes immunotherapeutic agents which employ cytotoxic T cells and/or antibodies, e.g., monoclonal, polyclonal, phage antibodies, or fragments thereof, which are utilized in the selective destruction of undesirable rapidly proliferating cells. For example, immunotoxins can include antibody-toxin conjugates (e.g., Ab-ricin and Ab-diptheria toxin), antibody-radiolabels (e.g., Ab-I135) and antibody activation of the complement at the tumor cell. The use of immunotoxins to inhibit, reduce, or prevent symptoms or conditions associated with neoplastic diseases are well known in the art (see e.g., Harlow, E. and Lane, D., Antibodies, (1988)).
The language "inhibiting undesirable cell growth" is intended to include the inhibition of undesirable or inappropriate cell growth. The inhibition is intended to include inhibition of proliferation including rapid proliferation. For example, the cell growth can result in benign masses or the inhibition of cell growth resulting in malignant tumors. Examples of benign conditions which result from inappropriate cell growth or angiogenesis are diabetic retinopathy, retrolental fibrioplasia, neovascular glaucoma, psoriasis, angiofibromas, rheumatoid arthritis, hemangiomas, Karposi's sarcoma, and other conditions or dysfunctions characterized by dysregulated endothelial cell division.
The language "inhibiting tumor growth" is intended to include the prevention of the growth of a tumor in a subject or a reduction in the growth of a pre-existing tumor in a subject. The inhibition also can be the inhibition of the metastasis of a tumor from one site to another. In particular, the language "tumor" is intended to encompass both in vitro and in vivo tumors that form in any organ or body part of the subject. The tumors preferably are tumors sensitive to the aminoguanidine compounds of the present invention. Examples of the types of tumors intended to be encompassed by the present invention include those tumors associated with breast cancer, skin cancer, bone cancer, prostate cancer, liver cancer, lung cancer, brain cancer, cancer of the larynx, gallbladder, pancreas, rectum, parathyroid, thyroid, adrenal, neural tissue, head and neck, colon, stomach, bronchi, kidneys. Specifically, the tumors whose growth rate is inhibited by the present invention include basal cell carcinoma, squamous cell carcinoma of both ulcerating and papillary type, metastatic skin carcinoma, osteo sarcoma, Ewing's sarcoma, veticulum cell sarcoma, myeloma, giant cell tumor, small-cell lung tumor, gallstones, islet cell tumor, primary brain tumor, acute and chronic lymphocytic and granulocytic tumors, hairy-cell tumor, adenoma, hyperplasia, medullary carcinoma, pheochromocytoma, mucosal neuromas, intestinal ganglloneuromas, hyperplastic corneal nerve tumor, marfanoid habitus tumor, Wilm's tumor, seminoma, ovarian tumor, leiomyomater tumor, cervical dysplasia and in situ carcinoma, neuroblastoma, retinoblastoma, soft tissue sarcoma, malignant carcinoid, topical skin lesion, mycosis fungoide, rhabdomyosarcoma, Kaposi's sarcoma, osteogenic and other sarcoma, malignant hypercalcemia, renal cell tumor, polycythermia vera, adenocarcinoma, glioblastoma multiforma, leukemias, lymphomas, malignant melanomas, epidermoid carcinomas, and other carcinomas and sarcomas.
The present invention further pertains to a therapeutic and prophylactic composition for inhibiting tumor growth in a subject. The composition contains an effective amount of an aminoguanidine compound and a pharmaceutically acceptable carrier.
The present invention further pertains to packaged tumor growth inhibitors containing an aminoguanidine compound packaged with instructions for using the aminoguanidine compound as a tumor growth inhibitor. The instructions would provide such information as the appropriate dose of aminoguanidine or the appropriate regimen.
The contents of all references, pending patent applications and published patents, cited throughout this application are hereby expressly incorporated by reference.
Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments and methods described herein. Such equivalents are intended to be encompassed by the scope of the following claims.
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|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Mar 8, 2005
|Fee payment
Year of fee payment: 4
|Mar 11, 2009
|Fee payment
Year of fee payment: 8
|Apr 19, 2013
|Maintenance fee reminder mailed
|Sep 11, 2013
|Lapse for failure to pay maintenance fees
|Oct 29, 2013
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Effective date: 20130911


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BBB Accredited Business since
Transpay, Inc.Additional Locations
Phone: (760) 776-5954 74900 US Highway 111 STE 121, Indian Wells, CA 92210 http://www.transpayprocessing.com View Additional Web Addresses
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Business ManagementMr. Mitchell Billman, President Ms. Kristy Razo, Director of Operations
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Information for Students is now available.
Information for Adjuncts and Casuals is now available.
Open Enrollment Period: November 2, 2015-December 4, 2015
Detailed information summarizing benefit plan changes, and other helpful Open Enrollment items are included in the Open Enrollment letter (pdf).
All enrollment forms with changes must be received in the human resources office by the Friday, December 4, 2015 deadline. Any changes you make will be effective January 1, 2016, as will any applicable changes to your 2016 payroll deductions.
The Benefits Fair in the Red Barn is a great opportunity to meet with representatives from the benefit plans and other on-campus groups and have your questions answered by the experts.
The annual benefits open enrollment period is the one occasion each year during which employees have the opportunity to make voluntary changes to their enrollment elections for their health, dental, and vision insurances as well as to their election to participate in the medical and/or dependent care Flexible Spending Accounts (FSA).
Donna Turban, payroll and benefits manager, will be on campus to assist you with Open Enrollment. If you have questions, need assistance with completing forms, or need to submit your forms, feel free to stop by and see her. She will be on campus on the following dates, times, and locations:
Tuesday, November 17, 2015, 3:30-4:30 p.m. FPH 101
Wednesday, November 18, 2015, 2-4 p.m. FPH Lounge
Monday, November 30, 2015, 11 a.m.-3 p.m. FPH Lounge
Thursday, December 3, 2015, 9 a.m.-2 p.m. FPH Lounge
Health Insurance Enrollment/Change Form (pdf) Find your insurance plan on the list below. Write the corresponding letter on the PRODUCT line next to the Member Section arrow (in blue) on the enrollment/change form.
Advantage (Low Cost) HMO Information
2016 Advantage (Low Cost) HMO Summary of Benefits (pdf)Low Cost HMO Deductible Details Information Sheet (pdf) REVIEW CLOSELY Low Cost HMO Member Information Sheet (pdf)Other Health Information and Reimbursement Forms
2016 HMO Summary of Benefits (pdf)2016 PPO Summary of Benefits (pdf)Fitness Reimbursement Form (pdf)Prescription Mail Order Form (pdf)Member Reimbursement Medical Claim Form (pdf)
Dental Insurance Enrollment/Change Form (pdf)Dental Claim Form (pdf)
Vision Insurance Enrollment/Change Form (pdf)
The IRS has set the maximum limit that you can elect for the health care spending account at $2,550 for 2016. The dependent care maximum remains at $5,000 for 2016.
Flexible Spending Account Enrollment Form (pdf)Flexible Spending Account Information Sheet (pdf)Health Care Flexible Spending Account Calculator (pdf)Dependent Care Flexible Spending Account Calculator (pdf)Flexible Spending Claim Form (pdf)
Our life insurance carrier is Symetra. The current basic life insurance benefit will remain at 2.0 times your annual salary benefit, up to a maximum of $150,000. Employees have the option to purchase additional life insurance for themselves, their spouses or partners, and children. This supplemental life insurance coverage is employee-paid.
Life Insurance Enrollment Form (pdf)Beneficiary Change Form (pdf)Life Insurance Evidence of Insurability Form (pdf)Life Insurance Summary of Benefits (pdf)
This website is intended as a general overview of Hampshire College benefits plans only. Every effort has been made to summarize these programs accurately. In all cases, the actual provisions of each benefit plan will govern if there is any inconsistency between this site and Hampshire's formal plans or contracts.
Open Enrollment Additional Information Packet
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This is a journey in my 2 years and a half of timelapsing throughout Italy and Europe. More…
From the desert of Morocco to the glaciers of Iceland, from italian landscapes to the fjords of Norway, traveling through Ireland: this timelapse short-film features 18 months of photo travels with FotoCorsi in the constant pursuit of the best light and location.
"Harris & Lewis" takes you on a journey through the breathtaking scenery found on the Outer Hebrides. More…
This year was amazing. I think that I've been a lucky guy, travelling all around the world to shoot commercials and documentaries. More…
Two weeks we lived the life of children of Kivumu , a tiny village in the center of Rwanda . We visited the site of another school building our new school that will , when finally be completed by the end of April, can accommodate as many as 1,000 students .
The ITALIA SENZA TEMPO team landed in Casentino. The park sited between Romagna and Tuscany is the scenario of the last video made by Angelo Chiacchio and Walter Molfese, two young Italian film-makers who have been exploring and capturing some of the most beautiful protected areas in Italy for several years.
New amazing video for Camera Slider PRO, realized by move11.
Shooted with Blackmagic URSA + Xeen Lenses
A project I have dreamed for years is now completed; "Tarvisiano Hidden Treasure" is finally online.
Salve a tutti, e questa volta non LIVE, ma via rete.
Nikon and ShooTools, an evolving species.
The realization of this timelapse only started as a game.
TimeLapse compilation of more than 10,000 photos taken between 31st March and 30th April 2015 in Central Australia
(two short segments in South Australia)
Tarvisiano Hidden Treasure is a timelapse project about a small mountain area called Tarvisiano, located in the North-East of Italy, on the Slovenian and Austrian border. Even if this hidden region is unknown to most people, it encases wonderful lakes, amazing mountains, big waterfalls and untouched nature.
Day 3 – Mount Acomizza
August 12th. It was 5 p.m. and it was time for a new adventure on my mountains. I choosed a location I had on my bucket list for a long time: mount Acomizza, a particular-shaped mountain on the Italian- Austrian border. More…
A short film realised by the Italian Filmmaker Giovanni Antico for the Astronomical Observatory of the Autonomous Region of the Aosta Valley. It gives a glimpse of its instruments and activities, from a typical guided visit for the public to scientific research.
Over 10 professional photographers,
Over 100.000 shots to select the best ones,
Over 5 countries from desert to the north europe.
Extreme condition -15° to +45°
The timelapse is composed of about 12 000 shots taken with two cameras; Nikon d800 and d700, two lenses Nikkor 14-24 f / 2.8, Nikkor 24-70 f / 2.8, and of course ShooTools Camera Slider with one 80 ShooTools Auto Pan More…


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1UP Club HeadquartersWelcome to 1UP's Clubs home. Here's where you can join, create, and manage clubs on your favorite topics.
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1UP_s Official Holiday Guide ClubIt's the ultimate holiday prize - a gamer's dream come true. Games from the 1UP.com Holiday Game Guide go into the Super Santa Sack, and one lucky Gamer wins it all! The Super Santa Sack will grow and grow from now until Dec 23rd, and everything in it will go to one lucky gamer. So how do you win? So simple -- 1UP members just need to join this club...
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Newsletter Sign-up
New Videos
Media Toolkit
Video Channels
Paul A. Mayewski, The Ice Chronicles: The Quest to Understand Global Climate Change. Science: World-renowned scientist and explorer, Paul Mayewski, describes his quest to understand global climate change and his new book. (Interview, 7 minutes).
Mary Gordon, Stuart Dybek, and Russell Banks take a short cut. Mary Gordon, Stuart Dybek, and Russell Banks read their stuff and take a few questions from the audience.
Norman Van Aken recalls his life in the collegial world of famous chefs and their culinary arts. The 'founding father' of New World Cuisine, an international fusion of Latin, Caribbean, Asian, African and American flavors, Norman Van Aken reveals how he found his way into the 'No Experience Necessary' world of Emeril Lagasse,Charlie Trotter, Alice Waters, and Julia Child.
Roz Chast tells all in 'What I Hate'. Staff cartoonist at The New Yorker and bestselling author of childrens and adult graphic books, Roz Chast talks about What I Hate and what she loves most.
All the world's your stage on AuthorCams. Nothing sells a book better than an author reading and talking about his or her work directly to his or her market.


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Any news?
Sentiment: Hold
Analysts flip flop very often. At the end of the day, if Softbank deal of 70% is approved then you get $7.35 per share of your 70% holdings... not a bad deal. So patience is key on this one.
You will not get $7.35 for 70% of your holding. You will get $7.30 for 55% of your holdings and new shares of the New Sprint at $5.25 a share for 45% of your holdings. You can opt for three options, the one I just outlined. or $7.30 for all your shares or all New Sprint shares at $5.25 a share. The second and third option are only if available if shares/money are available if not then the first option will be it. Lets work on getting S-Softbank deal done first hopefully before June 2013.
Sentiment: Buy
UBS downgraded Sprint on Monday AM....
UBS loading up today on their own downgrades .......


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Free personalized radio that
plays the music you love
Features of This Trackeast coast rap influences
danceable beats
consistent rhyme patterns
a deep voice
clear pronunciation
dissin' lyrics
lyrics about the rap industry
boastin' lyrics
emphasis on instrumental performance
inventive acoustic arrangements
a slow moving bass line
percussion layers
prominent percussion fills & solos
subtle use of turntables
a highly acoustic sonority
a dry recording sound
radio friendly stylings
an emphasis on instrumentation
These are just a few of the hundreds of attributes cataloged for this track by the Music Genome Project.show more
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Police Siren Free
Get your own piece of police equipment! Police Siren Free App is something you have to have on your Android phone. Attract everybody's attention with the best police siren sound effect and show them who the boss is. Play pranks on your friends with this cop siren or play police games outdoors. You can imagine you are a police officer who is chasi…
Free • 1K


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Main Content
- Material: 100% Plastic
- Officially licensed NFL product
- Dishwasher safe
- Made in the USA
- Prevents rings
- Air space keeps drinks at just the right temperature
- Holds approximately 16 ounces
- Quality embroidery
- Durable, high-grade polycarbonate
- Lifetime guarantee
- Reduces condensation
- Double wall insulation
- Imported
- Brand: Tervis
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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99 Reviews
ah yah! this pie is the bomb....when peaches aren't in season I grab 2 bags of frozen...OMG this pie is the best!
I was going through the recipes and realized I never rated this one. This pie is DELICIOUS! I made two and I got raves from the church at the potluck. I have since given it out a few times. It is definitely better with fresh peaches than with canned, but canned does work if you drain the peaches and dry them off before putting in the pie shell. Thanks for a keeper!
This is such a good pie. I made this for our Thanksgiving family dinner. I wanted something other then the usual pumpkin and pecan. I looked and had some frozen peaches that I wanted to use up and used them. I thawed, and drained them really good. They worked perfectly. Thank you for sharing with really really good pie. I will definately make this again, we all loved it. It has that extra "WOW" factor then your regular peach pie.
I'm giving this 3 stars but my husband gives it 5 . He absolutely loved it and demanded I make another immediately. Maybe I'm just not crazy about cooked peaches, but it didn't taste all that peachy to me. Plus, I couldn't taste the sour cream at all. Seems like a waste of good sour cream. However, since my husband loves it so much, I'll save it to my cookbook and will make it as often as he wants it. Even though it wasn't my favorite, I do thank you for posting it.
This pie is so good! I added a 1/2 tsp of cinnamon to the topping. I may try using brown sugar in the topping next time just to see how it would taste. Thanks for the great recipe.
I wasn't crazy about this pie. I used fresh, good peaches but their flavor was lost in the floury, sour cream pudding. I thought it was just too much flour in the recipe in general, as it was in the pie shell, the filling and the topping.
I made it this saturday when my brother in law came over for supper and we all loved it.I added a little cinnamon to the topping and that made it even better.
This was really good. I wish I liked peaches! Nonetheless, I can appreciate this pie. I used plain greek yogurt instead of sour cream (because that's how I roll). It turned out really well. I also couldn't resist adding a 1/4 tsp. almond extract. Tasty! I'd love to try this with blueberries next time since I am just not a peaches.
Wonderful pie, the best I have every made...
Great Pie. I don't make pies very often so this was a real treat. Only had four peaches which made 2 1/2 c. sliced. Made a fresh crust and baked as written.


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I don't have kids yet, but I do pack a lunch daily for myself and my guy and I know how easy it is to be stuck in a rut. I try to stick 80% paleo, and attempt to stay away from gluten as much as possible as it bothers me.
There are a lot of paleo websites out there that have a ton of ideas, but these are some of my favorite:
1. paleononpaleo.com is a down to earth approach to lunch prep. She attempts to keep thing simple and efficient, including a school lunch menu chart she keeps on the fridge. Check out her 10 Super-Efficient Steps to Hacking Paleo School Lunches!
2. thepaleomama.com has 40 ideas for school lunches, complete with photos. She is not 100% paleo and includes such things as dairy, Nut Thins and some rice. Check out her 40 Days of Gluten Free School Lunches!
3. nomnompaleo.com put together 5 days of Paleo lunches last year, and has done it again this year! The photos look scrumptious. She's got a cheeky attitude which I like also. If you scroll to the bottom of the page she also has links to school lunch ideas from:
- Everyday Paleo
- Primal Bliss
- Deliciously Organic
- Paleo Parents
- Our Paleo Life
- The Paleo Mom
- The Paleo Network
- My Paleo Lunch Boxes


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U.S. places 3 in top 10 of women's Olympic marathon for the first time, led by Shalane Flanagan in 6th
RIO DE JANEIRO — Since Joan Benoit Samuelsen won the inaugural women's Olympic marathon at the 1984 Los Angeles Games, only four other U.S. women had cracked the top 10 before Sunday's race when all three U.S. women did it. Shalane Flanagan, who was 10th in London four years ago, finished sixth in two hours, 25 minutes, 26 seconds, which was 1:22 behind gold medalist Jemima...
Via The Denver Post
25 days ago
Tar Heels News 8/14/16: Running back Zamir White calls UNC visit great
Sports Illustrated | Jamie Lisanti: Former Tar Heel Shalane Flanagan has a unique diet as an Olympic marathon runner. Her post-race treat? Doughnuts. While Flanagan doesn't get too bogged down with calorie counting, she does pay close attention to what she eats before a race. The Robesonian | Rodd Baxley: Lumberton High School running back Zamir White visited UNC and called his...
Via Tar Heel Blog
26 days ago
How have former UNC athletes done so far at the Olympics?
North Carolina is well represented in Rio, lets see how they've done so far. Fifteen UNC alums are taking part in the 2016 Olympics. Of that 15, only two have yet to participate in the games. Shalane Flanagan and Vikas Gowda will take part in the Track and Fields events which take place in the second week. The other 13 athletes' events have begun, and many of them have had fairly...
Via Tar Heel Blog
27 days ago
Olympic marathoners Flanagan, Cragg to run B.A.A. 10K
BOSTON (AP) Olympic marathoners Shalane Flanagan and Amy Cragg will tune up for the Rio de Janeiro Games by running in the Boston Athletic Association 10K later this month. Flanagan is a four-time Olympian and 2008 Olympic bronze medalist on the track. The Marblehead, Massachusetts native has run the Boston Marathon three times, finishing fourth, sixth and ninth. Her time of 2...
Via Associated Press
June 20, 2016 | Discuss
Olympian Flanagan wins Rock 'n' Roll half marathon
SAN DIEGO (AP) U.S. Olympian Shalane Flanagan won the women's half marathon in 1:07:51 at the Rock `n' Roll Marathon on Sunday, breaking her personal best by 40 seconds. It was the second-fastest half marathon by an American this year, behind Molly Huddle's 1:07:41 at the NYC Half in March. Amy Cragg, who beat Flanagan at the U.S. Olympic Trials marathon in February, finished...
Via Associated Press
June 05, 2016 | Discuss
Cragg, Flanagan, Meb to run Rock 'n' Roll half marathon
SAN DIEGO (AP) U.S. Olympians Amy Cragg, Shalane Flanagan and Meb Keflezighi will run in the half marathon at the Suja Rock `n' Roll San Diego Marathon on Sunday. Cragg and Flanagan will run the 13.1 miles as their only event prior to the Olympics in August. Keflezighi will pace the 90-minute group in the half marathon, starting in a special ''Meb Corral'' after the elite runners...
Via Associated Press
June 04, 2016 | Discuss
Cragg wins marathon trial, earns spot on US Olympic Team
LOS ANGELES (AP) Amy Cragg has won the steamy U.S. Olympic Team Marathon Trials, earning a berth to the Rio Games. Cragg finished ahead Desiree Linden and Shalane Flanagan, who also made the Olympic team by finishing in the top three. Cragg, who fourth in the trials four years ago, pulled away late to win in 2 hours, 28 minutes and 27 seconds. Linden rallied in the final mile...
Via Associated Press
February 13, 2016 | Discuss
Flanagan sets American 10K road record in Holland
HOLLAND, Netherlands -- Shalane Flanagan (Marblehead, Massachusetts) set an American record Sunday at the Tilburg Ten Miles in Holland, Netherlands.
Via USA Track & Field
September 05, 2015
Caroline Rotich, Lelisa Desisa Among 119th Boston Marathon Winners
The cold and the wind didn't stop some of the world's top runners in the 119th running of the Boston Marathon on Monday. Caroline Rotich of Kenya claimed the women's title with a time of 2:24:55. It was an exciting finish in the elite women's division, as Rotich sprinted past Ethiopia's Mare Dibaba down the final stretch of Boylston Street to earn her first victory in...
Shalane Flanagan Posts Fastest Time For U.S. Woman At Boston Marathon
The records keep on coming for U.S. runners at the 2014 Boston Marathon. In a day that saw American Meb Keflezighi become the first male U.S. runner to win the Boston Marathon since 1983, Marblehead, Mass., native Shalane Flanagan made history by posting the fastest time ever for an American woman on the Boston course. The 32-year-old finished seventh overall, crossing the finish...
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Flights to Saltillo
Flights to SaltilloFlights to Saltillo (Mexico)
Fly to Saltillo (Mexico) with Destinia. We offer you flights at economical prices or in the class you choose. To select your flights Saltillo, type the name of the city you wish to depart from in the Departure box and write Saltillo in the Arrival field. Then select the departure and return dates. You can buy several airline tickets to Saltillo at the same time by indicating the number of adults, children and babies travelling. You can filter the type of flight if you are only interested in direct flights to Saltillo (Mexico), multiple destinations or flight stopovers.
Airports near Saltillo
Saltillo has one airport: Saltillo (SLW), located 14 km away from the city centre. The hotels in Saltillo closest to its airport are:
- Hotel Posada Agua Escondida (SLW)
- Hampton Inn Saltillo Airport Area (SLW) from €34€
Top destinations in MexicoBook your flights now from Saltillo (Mexico) to the most important cities in the world. The box below contains flights from Saltillo (Mexico) to the most important cities.
- Flights to Veracruz
- Flights to Tapachula
- Flights to Mazatlan
- Flights to Santa Maria Huatulco
- Flights to Torreon
- Flights to Reynosa
- Flights to Cordoba
- Flights to Puerto Vallarta
- Flights to Chihuahua
- Flights to Guaymas
- Flights to Puebla
- Flights to San Jose del Cabo
- Flights to Culiacan
- Flights to Ensenada
- Flights to Leon
- Flights to Cuernavaca
- Flights to Ciudad Juárez
- Flights to Uruapan
- Flights to Campeche
- Flights to Tijuana
In Saltillo we will have moderate rain, light attire is recommended as the temperatures will be warm throughout the day.
- Tuesday
- Wednesday


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EPA Methods Companies in Thailand
Current filtering criteriaYou can remove a filter by clicking on the x
Apex Instruments, Inc.
Distributor in THAILAND
Apex Instruments was established in 1988 as an American-owned company with worldwide impact. For more than 24 years, Apex Instruments has manufactured equipment for sampling emissions from industrial chimneys and smoke stacks using US-EPA guidelines. Our equipment is designed by a staff of experienced stack testers who understand your compliance testing needs.
atg UV Technology
Distributor in THAILAND
atg UV Technology are leaders in the design and manufacture of UV (ultraviolet) disinfection / treatment systems for municipal drinking water and waste water, oil and gas applications, industrial process water and aquatics. Our applications include: Municipal: Drinking water (validated), waste water, storm water, advanced oxidation, waste water re-use. Oil & Gas: Drinking ...
Entech Associate Co., Ltd.
based in Toongsonghong, Laksi, THAILAND
Entech Associate Co.,Ltd. was established since 1994. The firm's business is import and selling measuring instruments in the fields of industrial, Energy, Safety, Environmental, and medical and laboratory. Our services are selling, consulting, Products Training, Installation, Calibration and all about after sales services by the experienced technician teams with hoping ...
Analytik Jena AG
Office in Thungsonghong, Laksi, Bangkok , THAILAND
Analytik Jena is a leading provider of high-end analytical measuring technology, instruments, and products in the fields of biotechnology and molecular diagnostics and high quality liquid handling and automation technologies.
Cooper Environmental
Distributor in Toongsonghong, Laksi, THAILAND
Cooper Environmental has the unique capability to measure and interpret elements using X-ray Fluorescence (XRF) in a fully-automated fashion. Using this core technology, Cooper was the first to commercially manufacture an XRF-based multi-metals continuous emissions monitoring system (CEMS) in the world. This automated XRF technology is also used to measure and interpret ...
HORIBA Europe GmbH
Office in THAILAND
The HORIBA Group of worldwide companies provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing and metrology, to a broad range of scientific R&D and QC measurements. Proven quality and trustworthy performance have established ...