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Seamus Heaney, Nobel-Winning Poet, Dead at 74
Prize Committee Lauded Irishman for Exalting 'Everyday Miracles and the Living Past'
LONDON— Seamus Heaney, one of the 20th-century's greatest poets and a Nobel laureate, was loved by critics and everyday readers alike. He was so admired in Ireland that locals referred to him as Famous Seamus.
Mr. Heaney died Friday in a Dublin hospital after a short illness, according to a statement from his publisher, Faber & Faber. He was 74.
The most acclaimed Irish poet since William Butler Yeats, Mr. Heaney's work often focused on everyday life in his homeland of Northern Ireland, "its farms and cities beset with civil strife, its natural culture and language overrun by English rule," according to the Chicago-based Poetry Foundation, publisher of Poetry magazine.
The Nobel committee praised his poems for their "lyrical beauty and ethical depth, which exalt everyday miracles and the living past" upon awarding Mr. Heaney the literature prize in 1995.
"For us, Seamus Heaney was the keeper of language, our codes, our essence as a people," Irish Prime Minister Enda Kenny said. "We are blessed to call Seamus Heaney our own and thankful for the gift of him in our national life. He belongs with Joyce, Yeats, Shaw and Beckett in the pantheon of our greatest literary exponents."
Mr. Heaney was born in 1939 on a farm in Castledawson in Northern Ireland, an Irish Catholic in a mostly Protestant part of the U.K.
While studying English at Queen's University in Belfast, he was inspired to try his hand at poetry after reading Ted Hughes, Patrick Kavanagh and Robert Frost.
The poet's first book, "Death of a Naturalist," published in 1966, begins with "Digging," which would become one of his most famous poems. Describing the image of Mr. Heaney's father digging in the earth, the poem attempts to reconcile the poet's own profession with his ancestors' agrarian past:
But I've no spade to follow men like them.
Between my finger and my thumb
The squat pen rests.
I'll dig with it.
He resigned his post as a lecturer at Queen's University and moved his family south to Dublin after the Bloody Sunday massacre of 1972, when unarmed civil rights protesters in Northern Ireland were shot by British soldiers.
Over the years he offered various explanations for the move, according to the book "Seamus Heaney: The Making of a Poet," by Michael Parker.
He was determined to pursue a career as a poet, and wanted to escape the high tax rates in the North, according to the book. Mr. Heaney also offered political explanations, saying Belfast was "not a good place to bring up children," and that he didn't want his presence to be used "to bolster a state whose legitimacy he denied," according to the book.
The Protestant Telegraph rejoiced at the departure of what it called a "papist propagandist," while the Irish Times in Dublin celebrated his arrival with the headline "Ulster Poet Moves South."
Mr. Heaney was professor of poetry at Oxford University from 1989 to 1994. Starting in 1985 he held various posts at Harvard University, including visiting professor and poet in residence.
Friends and colleagues recall him as brilliant, witty, companionable and humble.
Don Share, now the editor of Poetry magazine, remembers a surprise visit from the poet when he started work as Harvard's curator of poetry in 2000.
"I wasn't a big deal or anything," Mr. Share recalls. So he was shocked to find Mr. Heaney sitting in a chair outside his office on his first day of work.
Mr. Heaney said he was "reporting for duty, because somewhere buried in the fine print it said one of his roles was to be an adviser to the curator of poetry," Mr. Share says. "He was probably one of the three or four most famous living writers at the time. I was amazed."
Mr. Share compares Mr. Heaney to Mr. Frost, the American poet, for his ability to "talk to anybody."
"He could talk to great crowds or to individual people, not only as a poet but as a fellow sufferer," Mr. Share says. When Mr. Heaney held readings in Cambridge, Mass., "there'd be a line out the door," he adds.
Ciaran Carson, a poet and director of the Seamus Heaney Centre for Poetry at Queen's University, Belfast, cites a work from Mr. Heaney's most recent collection, "Human Chain," as among his favorites.
At the end of the poem, "A Kite for Aibhin," the kite string breaks: "The kite takes off, itself alone, a windfall."
"Somehow, he's like that now," Mr. Carson says of Mr. Heaney. "He's up in the air now but still hovering over us."
—Lee Watkins and Eamon Quinn contributed to this article.
Write to Jeanne Whalen at email@example.com


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subset: commoncrawl


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Genome sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2,951 putative LoF variants obtained from 185 human genomes to determine their true prevalence and properties. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely inactivated. We identify rare and likely deleterious LoF alleles, including 26 known and 21 predicted severe disease-causing variants, as well as common LoF variants in non-essential genes. We describe functional and evolutionary differences between LoF-tolerant and recessive disease genes, and a method for using these differences to prioritize candidate genes found in clinical sequencing studies.
Genetic variants predicted to severely disrupt protein-coding genes, collectively known as loss-of-function (LoF) variants, are of considerable scientific and clinical interest. Traditionally such variants have been regarded as rare and having a high probability of being deleterious, on the basis of their well-established causal roles in severe Mendelian diseases such as cystic fibrosis and Duchenne muscular dystrophy. However, recent studies examining the complete genomes of apparently healthy subjects have suggested that such individuals carry at least 200 (1, 2) and perhaps as many as 800 (3) predicted LoF variants. These numbers imply a previously unappreciated robustness of the human genome to gene-disrupting mutations, and have important implications for the clinical interpretation of human genome sequencing data.
Comparison of reported LoF variants between published genomes is complicated by differences in sequencing technology, variant-calling algorithms and gene annotation sets between studies (4, 5), and by the expectation that LoF variants will be highly enriched for false positives. The basis for this predicted enrichment is that strong negative natural selection is expected to act against the majority of variants inactivating protein-coding genes, thereby reducing the amount of true variation at these sites relative to the genome average, while sequencing error is expected to be approximately uniformly distributed; as a result, highly functionally constrained sites should show lower levels of observed polymorphism and substantially higher false positive rates (4). To date, no large-scale attempt has been made to validate the LoF variants reported in published human genome sequences.
LoF variants found in healthy individuals will fall into several overlapping categories: severe recessive disease alleles in the heterozygous state; alleles that are less deleterious but nonetheless have an impact on phenotype and disease risk; benign LoF variation in redundant genes; genuine variants that do not seriously disrupt gene function; and, finally, a wide variety of sequencing and annotation artifacts. Distinguishing between these categories will be crucial for the complete functional interpretation of human genome sequences.
We identified 2,951 candidate LoF variants using whole-genome sequencing data from 185 individuals analyzed as part of the pilot phase of the 1000 Genomes Project (2), as well as detailed analysis of high-coverage whole-genome sequencing data from a single anonymous European individual (6). The individuals represented 3 population groups: Yoruba individuals from Ibadan, Nigeria (YRI), 60 individuals of Northern and Western European origin from Utah (CEU) and 30 Chinese individuals from Beijing and 30 Japanese individuals from Tokyo that were analyzed jointly (CHB+JPT).
We adopted a definition for LoF variants expected to correlate with complete loss of function of the affected transcripts: stop codon-introducing (nonsense) or splice site-disrupting single nucleotide variants (SNVs), insertion/deletion (indel) variants predicted to disrupt a transcript's reading frame, or larger deletions removing either the first exon or more than 50% of the protein-coding sequence of the affected transcript. We further sub-divided these variants into "full" LoF variants predicted to affect all known protein-coding transcripts of the affected gene, and "partial" variants affecting only a fraction of known coding transcripts. All annotation was performed against the Gencode v3b annotation (7) using the algorithm VAT (8).
We then subjected our candidate list to a series of stringent informatic and experimental validation steps (9). Informatic filtering was based on local sequence context (such as the presence of highly repetitive sequence), gene annotation (such as variants affecting non-canonical splice sites, or located close to the end of the affected open reading frame), analysis of the effects of nearby variants (such as neighboring SNVs altering the predicted functional effect of the candidate LoF variant), and measures of sequence read mapping and quality (Fig. S1). Where possible, thresholds for filtering were derived from the experimental validation experiments below.
We validated all candidate LoF SNVs and indels that were not excluded by other filters and for which we could design assays (n = 1,877) with experimental genotyping using three Illumina genotyping arrays and 819 custom Sequenom assays run, where possible, on all 185 samples from the low- and high-coverage 1000 Genomes pilot projects. Large deletions had previously been subjected to extensive validation (10), while those identified in NA12878 were assessed by comparison with independent 454 sequencing and array-based data from the same individual, as well as targeted capillary sequencing of variants in highly repetitive regions. Finally, 786 variants were re-examined by complete manual reannotation of the 689 affected gene models by experienced curators, using the HAVANA annotation pipeline (7), to identify annotation errors and flag variants unlikely to profoundly affect gene function. All 589 candidate LoF variants identified in NA12878 were subjected to independent genotype validation and complete gene model reannotation.
As expected, the proportion of likely sequencing and annotation errors in the initial candidate set was high, with overlapping sets of 25.0%, 26.8% and 11.1% examined LoF variants being excluded as representing likely sequencing/mapping errors, annotation/reference sequence errors, and variants unlikely to cause genuine LoF, respectively. Candidate LoF variants removed by filtering tended to be more common than high-confidence variants (Fig. 1A). False positive rates due to sequencing errors (Fig. 1B) were higher for LoF variants than for missense and synonymous variants in the CHB+JPT and YRI populations (P < 10−8 for all comparisons) and significantly higher than for missense variants in CEU (P < 0.05). Because most variants in a given genome are common, the comparatively high rate of annotation errors among high-frequency LoF variants meant that filtering resulted a large reduction in LoF variants per individual (Table 1).
We identified several sources of false positive LoF annotation that will require careful consideration in clinical sequencing projects. For instance, the predicted functional effect of a nonsense or frameshift variant can be altered by other nearby variants on the same chromosome (Table S1; Fig. S2), and predicted splice-disrupting SNVs and indels can be rescued by nearby alternative splice sites (Fig. S3). Both nonsense SNVs and frameshift indels are enriched towards the 3′ end of the affected gene, consistent with a greater tolerance to truncation close to the end of the coding sequence (Fig. 1C); putative LoF variants identified in the last 5% of the coding region were thus systematically removed from our high-confidence set, with the single exception of a known LoF indel in the NOD2 gene. There is also a discernible peak close to the 5′ end of genes, suggesting that some disrupted transcripts are rescued by transcriptional reinitiation at an alternative start codon (Fig. 1C).
Importantly, 415 (32.3%) of our high-confidence LoF variants are partial LoF variants, affecting only a subset of the known transcripts from the affected gene, meaning that functional protein may still be produced. We chose not to discard such cases, as it is currently impossible to assess the relative functional importance of different transcripts for most genes, and partial LoF mutations have previously been shown to be causal in Mendelian diseases (11).
In total, 43.5% (1,285/2,951) of our candidate LoF variants survived filtering. The resulting catalogue of high-confidence LoF variants is not complete: the 1000 Genomes pilot projects had low power to detect extremely rare variants (2), and we will not have detected certain classes of LoF variants, such as large gene-disrupting duplications, non-coding variants that disrupt gene expression or splicing regulation, or coding variants that destroy protein function without overtly disrupting an open reading frame (such as missense SNVs or in-frame indels). Several known LoF variant-containing genes such as ACTN3 (12) and CASP12 (13) were labeled as "polymorphic pseudogenes", meaning that the reference genome contains non-functional allele of the gene, whereas in other haplotypes the gene is functional (14); it is likely that we missed LoF variants in other uncharacterized genes from this class.
Nonetheless, this catalogue represents the largest available set of high-confidence human variants predicted to disrupt protein-coding genes. We note that the majority of the LoF variants identified here are novel: 70% of the high-confidence LoF SNVs and indels were not present in dbSNP prior to the 1000 Genomes pilot project.
Using the systematically curated list of variants from NA12878, we estimate that this anonymous individual with European ancestry carries 97 LoF variants, with 18 present in a homozygous state (Tables 1, S2). These numbers, while still indicating an unexpected tolerance for gene inactivation in humans and being considerably higher than those based on genotyping known nonsense SNVs alone (15), are substantially lower than most previously published estimates based on whole-genome sequencing (e.g. (2, 3, 16), and provide a benchmark for further studies of individual variation in functional gene content. This analysis also provides a robust estimate of different variant classes on gene inactivation: for instance, we find that 39% of genes inactivated in the NA12878 genome are the result of frame-shifting indels, a potentially serious concern given that indels are typically under-called using short-read sequencing approaches (2). Over a quarter (28.7%) of the LoF SNVs and indels in NA12878 affect only a subset of the known transcripts from the affected genes, emphasizing the need to consider alternative splicing in the annotation of functional effects.
LoF SNVs are strikingly enriched for low-frequency alleles compared to synonymous and missense SNVs (Fig. 1A), suggesting that many LoF variants are deleterious to human health and hence are prevented from increasing in frequency by purifying natural selection. Interestingly, the number of high-confidence LoF variants per individual is 25% higher in the YRI (Nigerian) sample than in the three non-African populations (P = 5.0 × 10−21; Table 1), suggesting a higher level of variation in functional gene content in African individuals consistent with their greater overall genetic diversity. However, we caution that larger samples with more homogeneous sequencing quality across populations will be required to confirm this finding and assess its likely functional impact.
We compared the properties of genes carrying at least one high-confidence LoF variant with those of other protein-coding genes. Genes containing high-confidence LoF alleles are relatively less evolutionarily conserved, showing a higher ratio of protein-altering to silent substitutions in coding regions between human and macaque (P = 2.8 × 10−52) and less evolutionary conservation in their promoter regions (GERP score; P = 3.7 × 10−16). On average, they have more closely related gene family members (paralogs) than other genes (P = 0.0058) and show greater sequence identity to paralogs (P = 0.0068), suggesting that in many cases their function may be partially redundant, and also increasing the possibility that LoF variants may be gained or lost through the process of gene conversion (17) as has recently been reported for disease mutations (18). They also have lower connectivity in both protein-protein interaction (P = 6.8 × 10−6) and gene interaction (P = 4.2 × 10−19) networks, suggesting that LoF-containing genes are generally less central to key cellular pathways, although there are caveats to this interpretation (9). LoF-containing genes are strongly enriched for functional categories related to olfactory reception, and depleted for genes implicated in protein-binding, transcriptional regulation and anatomical development (Table S8).
We estimated the probability that heterozygous inactivation of a given gene will be deleterious (a state known as haploinsufficiency) using a combination of functional and evolutionary parameters (9, 19). Our filtering process disproportionately removed candidate LoF variants with a higher predicted probability of haploinsufficiency, P(HI), consistent with the majority of putative LoF variants in highly functionally constrained genes being artifactual (Fig. 2A). High-confidence LoF variants remaining after filtering have significantly lower P(HI) than variants discarded by our filters (P = 2.1 × 10−16) or known haploinsufficient genes (P = 1.8 × 10−73).
We identified 365 genes with multiple candidate LoF variants. The majority of the genes with three or more independent LoF variants were found to represent systematic sequencing errors: for instance, the CDC27 gene contained 10 separate candidate splice-disrupting variants, all of which were found to represent mapping errors due to an inactive gene copy absent from the human reference sequence. Most of these variants were removed by filtering (Table S3). Of the remaining genes, some likely represent genes drifting towards inactivation in the population: for instance, the VWDE gene contains four separate high-confidence LoF variants, with 42.7% of the sequenced 1000G samples carrying at least one non-functional copy of this gene.
The high-confidence LoF set includes many known LoF variants reported to have effects on human traits (Table S4). We also found a number of previously uncharacterized LoF variants likely to have phenotypic effects. For instance, we identified three separate LoF variants in PKD1L3 and one in PKD2L1; the protein products of these two genes form a putative sour taste receptor complex (20, 21), so these variants may underlie variation in sour taste sensitivity between humans.
Our high-confidence LoF set includes many variants relevant to severe human disease. We identified 26 known recessive disease-causing mutations in our high-confidence LoF set, including mutations associated with the severe early-onset conditions Leber congenital amaurosis, harlequin ichthyosis, osteogenesis imperfecta and Tay-Sachs disease (Table S5). We also identified 21 strong candidates for novel disease-causing mutations: high-confidence LoF variants affecting all known transcripts of genes in which other null mutations have been convincingly associated with Mendelian disease, including adult-onset muscular dystrophy, Charcot-Marie-Tooth disease and mucolipidosis (Table S6). With one exception (a variant associated with transplant graft-versus-host disease) no individuals were homozygous for the putative disease-causing alleles.
Given the evidence for the presence of known deleterious variants, we hypothesized that LoF variants may also be enriched for association with risk of common, complex diseases. We investigated this hypothesis by imputing genotypes for 417 LoF SNVs and indels into a total of 13,241 patients representing seven complex diseases such as Crohn's disease and rheumatoid arthritis, along with 2,938 shared controls, who had previously been subjected to genome-wide SNP genotyping (22). We confirmed a previously known frameshift indel in the NOD2 gene associated with Crohn's disease, with a genome-wide significant imputed P value of 1.78 × 10−14 (two orders of magnitude more significant than the best tag SNP). However, no other LoF variants achieved genome-wide significance, and there was no overall excess of association signals in LoF variants compared to other coding variants (Fig. 2B). Since our catalogue is expected to contain most genuine LoF variants at greater than 5% frequency this result suggests that common gene-disrupting variants play a minor role in complex disease predisposition.
One explanation for the paucity of common LoF variants associated with complex disease risk is purifying selection, which is expected to prevent most severely deleterious alleles from reaching high population frequencies; this is consistent with the skew towards low frequencies amongst high-confidence LoF variants (Fig. 1A). In addition, genes containing homozygous LoF variants have more gene family members (median 5 vs 3; P = 3.76 × 10−3) and are less conserved between macaque and human (P = 1.87 × 10−4) than genes containing only heterozygous LoF variants, suggesting greater redundancy in genes affected by high-frequency loss of function. Similarly small effects on complex disease risk have previously been noted for large, common copy-number variations, another class of variant with a high prior probability of functional impact (23).
Genotype imputation and case-control association studies have low power to detect associations for low-frequency variants, so further experiments involving direct genotyping of LoF variants in large disease cohorts will be required to characterize the impact of rare LoF variation on human complex disorders.
We examined the impact of validated nonsense SNVs on gene expression using RNA sequencing data generated from lymphoblastoid cell lines of 119 samples from two populations (24, 25). Comparison of the relative expression of the LoF and functional alleles within experimentally genotyped heterozygous individuals (Fig. 2C; Table S7) revealed a statistically significant reduction in expression from the LoF allele in 8/49 (16.3%) of variants with sufficient sequencing depth to be assayed. As expected, this reduction in expression is most common for variants predicted to trigger nonsense-mediated mRNA decay (NMD), a cellular process that degrades premature stop codon-containing transcripts: 7/28 (25.0%) of predicted NMD-triggering variants show significant evidence of decay, compared to 1/21 (4.8%) of predicted NMD-evading variants, and the proportion of reads mapping to the alternate allele was significantly lower for predicted NMD-triggering variants (median 0.352 vs 0.481; P = 0.0023). However, most predicted NMD-triggering variants have no detectable effect on gene expression.
These results provide functional confirmation of true loss of gene function for a minority of LoF variants. In addition, they demonstrate that the most widely-used algorithm for NMD prediction (26) is an imperfect indicator of the effects of nonsense SNVs on RNA expression.
We explored whether LoF variants as a class showed evidence of recent positive selection, as expected under the "less is more" hypothesis of adaptive gene loss proposed by Olson (27). We examined the overlap between high-confidence LoF variants and regions showing potential signatures of positive selection using frequency spectrum and haplotype length-based tests on 1000 Genomes pilot data (2). In contrast to the "less is more" hypothesis, LoF variants overlapped with positively selected regions no more often than frequency-matched synonymous SNVs. However, we have identified 20 high-confidence LoF variants in candidate regions for positive selection that warrant further analysis (Table S10).
In some cases, selection for gene inactivation may act through the accumulation of multiple rare LoF variants rather than increased frequency of a specific LoF allele. We identified one potential example of this: in addition to a relatively common nonsense SNV in the CD36 gene reported to be the target of positive selection in African populations (28) we identified two rare, novel splice-disrupting SNVs in the same gene. All three of these variants were specific to the Yoruban (YRI) population, suggesting that multiple null alleles for CD36 may be accumulating in African populations under the influence of selection.
Homozygous inactivation of a gene can have a range of phenotypic effects: at one end of the spectrum are severe recessive disease genes, while at the other end are genes that can be inactivated without overt clinical impact, referred to here as LoF-tolerant genes. Clinical sequencing projects seeking to identify disease-causing mutations would benefit from improved methods to distinguish where along this spectrum each affected gene lies.
Genes homozygously inactivated in 1000 Genomes Project samples are likely to fall close to the LoF-tolerant end of the spectrum. These genes therefore represent a comparison group that can be used to define the functional and evolutionary characteristics that distinguish these genes from severe recessive disease genes.
We examined the 253 genes containing validated LoF variants that were found to be homozygous in at least one individual. These LoF-tolerant genes are significantly less conserved and have fewer protein-protein interactions than the genome average (Fig. 3A). They are also enriched for functional categories related to chemosensation, largely explained by the enrichment of olfactory receptor genes in this class (13.0% vs 1.4% genome-wide), and depleted for genes involved in embryonic development and cellular metabolism (Table S8).
We then identified parameters that could be used to classify candidate genes along the disease/LoF-tolerant spectrum. We first removed olfactory receptors from the LoF-tolerant set, as these genes could be easily excluded as candidates for most severe Mendelian diseases, leaving 213 LoF-tolerant genes to compare with 858 known recessive disease genes. These two gene categories were found to display marked differences in a wide range of properties (Fig. 3A).
We developed a linear discriminant model based on human-macaque conservation and proximity to recessive disease genes in a protein-protein interaction network to classify genes into LoF-tolerant and recessive disease classes (Fig. 3B, 3C). Although insufficient to definitively discriminate between the two classes, this algorithm could be used to prioritize candidates identified by sequencing recessive disease patients for replication and functional follow-up. We have calculated a recessive disease probability score for each protein-coding gene in the genome for use in such analyses (9).
Here we describe a stringently filtered catalogue of variants disrupting the reading frame of human protein-coding genes, including the majority of such variants present at a population frequency of 5% or greater. Because large numbers of candidate LoF variants are present in the genomes of all individuals, but are highly enriched for a variety of sequencing and annotation errors, there is a need for caution in assigning disease-causing status to novel gene-disrupting variants found in patients. More reliable reference gene sets will help: reference sequence and automated gene annotation errors accounted for 44.9% of candidate LoF variants in our deeply characterized individual genome, but most of these have now been corrected as a result of this project and other manual annotation efforts.
Our stringent filtering of the LoF variants found in a single high-quality human genome suggests that a typical "healthy" genome contains ~100 genuine LoF variants, with most of them carried in the heterozygous state. Given that humans (29) and other species (30) have been estimated to carry fewer than 5 recessive lethal alleles per genome, it seems likely that the majority of LoF variants found in an individual genome are common variants in non-essential genes, although these may still have an effect on human phenotypic variation. Nonetheless, the signature of strong purifying selection against high-confidence LoF variants as a class, and the discovery of numerous known and predicted severe recessive disease alleles, indicates that many LoF alleles with large effects on human fitness exist at low frequency in the human population. Large sequencing and genotyping projects will be required to uncover the full spectrum of these variants and their effects on human disease risk.
We have found that LoF-tolerant and recessive disease genes have differing functional and evolutionary properties, allowing us to develop a potential approach for prioritizing novel candidate recessive disease variants identified in patient samples for functional follow-up. As further examples of LoF-tolerant genes are obtained from high-throughput sequencing studies the power of this type of classification approach is likely to grow considerably.
Finally, we note that our catalogue of validated LoF variants comprises a list of naturally occurring "knock-out" alleles for over 1,000 human protein-coding genes, many of which currently have little or no functional annotation attached to them. Identification and systematic phenotyping of individuals homozygous for these variants could provide valuable insight into the function of many poorly characterized human genes.
T. Shah provided the Pyvoker software used for manual assignment of genotypes based on intensity clusters, S. Edkins was involved in the Sequenom validation, and the genotyping groups at Illumina, the Wellcome Trust Sanger Institute and The Broad Institute of Harvard and MIT provided raw intensity data for the three Illumina arrays used for genotyping validation. The work performed at the Wellcome Trust Sanger Institute was supported by Wellcome Trust grant 098051; DM was supported by a fellowship from the Australian National Health and Medical Research Council; GL by the Wellcome Trust (090532/Z/09/Z); ETD and SBM by the Swiss National Science Foundation, the Louis Jeantet Foundation and the NIH-NIMH GTEx fund; KY by NWO VENI grant 639.021.125; and HZ, YL and JW by a National Basic Research Program of China (973 program no. 2011CB809200), the National Natural Science Foundation of China (30725008; 30890032; 30811130531), the Chinese 863 program (2006AA02A302;2009AA022707), the Shenzhen Municipal Government of China (grants JC200903190767A; JC200903190772A; ZYC200903240076A; CXB200903110066A; ZYC200903240077A; and ZYC200903240080A) and the Ole Rømer grant from the Danish Natural Science Research Council, as well as funding from the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen. JKP is on the scientific advisory board of 23andMe and RAG has a shared investment in Life Technologies. Raw sequence data for the 1000 Genomes pilot projects are available from www.1000genomes.org, and a curated list of the loss-of-function variants described in this manuscript is provided in the Supplementary Online Material.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Mrs. R.J. Cabrera, Writing, Editing, and Regulatory Coordination, VS, APHIS, 4700 River Road Unit 35, Riverdale, MD 20737-1231; (301) 851-3478.
Supplementary Information
The Animal and Plant Health Inspection Service (APHIS) has established a Veterinary Services (VS) Stakeholder Registry, an email subscription service for individuals and organizations interested in receiving updates regarding APHIS and VS issues. Subscribers will be able to choose from an array of topics such as VS spotlights and news releases, Federal notices, and current VS programs, as well as material sorted by diseases, guidance documents and manual updates, and updates on frameworks for proposed and final rules. In addition to choosing topics of interest, subscribers may select how often they want to receive email messages.
Persons interested in becoming subscribers may sign up now for the new registry at . Questions concerning the VS registry may be directed to the person listed under FOR FURTHER INFORMATION CONTACT.
Done in Washington, DC, this 9th day of April 2012.
Kevin Shea,
Acting Administrator, Animal and Plant Health Inspection Service.
[FR Doc. 2012-8913 Filed 4-12-12; 8:45 am]
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Date Posted: Apr 13, 2012
Federal Register Number: 2012-08913
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Posted 12.04.2012
Leading local sign makers, Signs Express (Lancaster) were on hand to support their local town of Morecambe in their bid to a share of the government funded Portas Pilot project of £1m aimed at helping to support and grow the economies in towns and villages.
As a community project, local businesses and community leaders as well as the general public have all come together to back a campaign for Morecambe to win the funding under the strapline 'MoreCanBe Done'.
Signs Express (Lancaster) has offered financial support as well as their signage expertise to help promote the campaign. Large format full colour graphics have been applied in strategic locations across the town offering a dual purpose – covering unsightly vacant shop windows as well as encouraging community interaction and support for the initiative.
The campaign, which has been created by Lancaster based marketing agency SATO, is the backbone of the application organised by the Town Team of local businesses. The application for the Portas Pilot project promotes their vision of Morecambe as a destination for socialising, culture, wellbeing, learning as well as shopping.
The marketing campaign has used social media as well as traditional advertising, leaflets and postcards to increase awareness and encourage community participation.
Owner of Signs Express (Lancaster) Thomas Somers said, "This initiative is vital for towns such as Morecambe and we were delighted to offer our assistance. Unfortunately Morecambe has seen a number of closures, especially retail, during the recession which has lead to over 30% of retail space within the town being vacant. By adding large full colour imagery to shop windows backing the campaign we are not only adding a bright and attractive image to the high street but spreading the very important message of the importance this project has to the community".
Retail expert Mary Portas is spearheading the dynamic campaign following an independent review into the future of the high street carried out last year. Mary's report set out a vision that "the High Streets of the future should be multi-functional and social places bustling with people, services and jobs which offer a clear and compelling purpose and experience that's not available elsewhere, and which meets the interests and needs of the local people". Mary made a number of recommendations to help achieve that vision and the government have acted by initiating pilot schemes to 12 towns across the country.
The government has invited bids from Town Teams to apply for the chance to be part of the pilot campaign and hundreds of towns have applied for a share of the £1m funding aimed to encourage growth and community spirit within towns. Morecambe will hear along with other hopeful towns if they have been successful at the end of May.
For further information visit http://www.facebook.com/morecanbedone or follow the campaign via twitter http://www.twitter.com/morecanbedone
More details about our Lancaster Branch
Signs Express Lancaster supports the MoreCanBe Done campaign


text:
I ride Santa Teresa a lot. Yet I rarely get the opportunity to show newer riders this park as I'm usually riding the more advanced technical trails during our Intermediate level Wednesday night rides. This ride is going to be something entirely different. We'll start from a small lot down the road and get right to riding sweet single track. There is a little known trail that runs along the creek and paved path. It features almost no climbing and is full of fun little twist and turns to give newer riders plenty of a warm up before we climb into Santa Teresa Park.
Now this ride is technically not all inside of Santa Teresa (STP) but it features a trail that I frequented for weeks before making my way onto the more technical trails of what is now my favorite local ride. If you're just starting out or just getting back from some time off the bike this is a great ride for you. We'll take it easy with our pace along trails where it will be very hard for anyone to get lost or separated on. As always you're in good hands when you ride with us and I'll do my best to ensure everyone has a great time.
See you out on the trails,
David B.
Here's a link to the route we'll take for those that like to know where you're going.
Never beginner or easy pace when riding with David. Pace is as brisk as you want it to be.I still suck at Stiles
0 · August 20, 2013
What is the elevation for this ride? Is it gradual with flat or downhill interspersed with the uphill? I want to make sure I am not in over my head.
0 · August 19, 2013
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China's industrial output grew 6.0% year-over-year in May, unchanged from the previous month's reading and in line with the market forecast. In the meantime, the country's retail sales jumped 10.0% >>
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CHF/JPY 1D Chart: Channel Down
Mon, 13 Jun 2016 08:46:09 GMT
Starting from last year's June, the Swiss Franc has been consistently underperforming the Japanese Yen, which has eventually led to formation of the bearish channel. Accordingly, we expect any near-term >>
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USD/JPY dives, as risk-off sentiment preponderates
Mon, 13 Jun 2016 08:35:58 GMT
Friday and the weekend were rather favourable for the US Dollar, being that it appreciated against most major currencies. >>
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Dukascopy Aggregate Technical Indicator Morning
Mon, 13 Jun 2016 08:31:14 GMT
Dukascopy Aggregate Technical Indicator for 30 min, 1H, 4H and 1D time frame charts for major pairs for the last 144 periods till 07:30 GMT. >>
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EUR/USD falls to 1.125 on Friday
Mon, 13 Jun 2016 08:20:46 GMT
The Euro continued making gains against the US Dollar last week and even went past the 1.14 mark. However, the currency exchange rate retreated in the last two days of >>
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GBP/USD remains subject to weakness
Mon, 13 Jun 2016 08:20:35 GMT
The British currency suffered heavy losses against all other major currencies on Friday and over the weekend, amid a 'Brexit' poll published on Friday. >>
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EUR/AUD 4H Chart: Channel Down
Mon, 13 Jun 2016 08:20:17 GMT
During the previous month the currency pair failed to gain a foothold above 1.56 and thus missed an opportunity to test the 10-month falling resistance line at 1.58. Since then >>
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Morning Press Review
Mon, 13 Jun 2016 08:09:14 GMT
Stay informed about the latest news on the economy, politics, FX by reading our press review with top videos and comments from world's leading financial bloggers. >>
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Gold reaches 1,275 on Monday
Mon, 13 Jun 2016 07:58:14 GMT
The bullion continued its surge on Friday, as the yellow metal gained strength and the price changed from 1,268.61 to 1,272.83. >>
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USD/JPY dives, as risk-off sentiment preponderates
Mon, 13 Jun 2016 07:47:13 GMT
As was anticipated the USD/JPY currency pair kept gravitating towards the 107.00 major level on Friday, unable to close far away from that area and, as a result, remained relatively >>
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Gold reaches 1,280 level on Monday morning
Mon, 13 Jun 2016 07:36:43 GMT
As the risk-off sentiment continues to increases in the markets, gold gains strength. The bullion was the top performer between commodities, as it surged by 0.4% on Friday. >>
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GBP/USD remains subject to weakness
Mon, 13 Jun 2016 07:36:05 GMT
The Sterling was unable to preserve the ascending channel pattern last Friday, as it unexpectedly dropped more than 275 pips against the US Dollar, with the decline triggered by the >>
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EUR/USD drops to 1.125 on Friday
Mon, 13 Jun 2016 07:35:38 GMT
The Euro depreciated against the US Dollar on Thursday and Friday falling to the level of 1.125, which is almost halfway down to the level of 1.115, at which the >>
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EUR/SGD 1H Chart: Channel Down
Mon, 13 Jun 2016 07:35:15 GMT
Since the last time we looked at EUR/SGD, the pair has remained within the boundaries of the channel. However, even though the technical indicators and the pattern imply further depreciation >>
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Upbeat Canadian employment change drives unemployment rate lower
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Mitt is attacking Newt for allegedly lobbying on behalf of Freddie Mac and President Bush's prescription drug benefit. Newt maintains that he never "lobbied." So we now have a two-ships-passing-in-the-night fiasco reminiscent of the "torture" debate.
The popular understanding of lobbying is importantly different from the narrower concept of legally actionable lobbying. Both sides throw the term around without explaining the distinction — Mitt darkly suggests that Newt has not only associated himself with one of the immensely unpopular mortgage giants but done something unethical — or perhaps even illegal — in the process; Newt responds that there is nothing to see here because he consulted lawyers in order to stay on the legal side of the barrier — as if any sort of facilitation or promotional work in support of wayward private/public enterprises, which disastrously intrude government into the private sector, is fine as long as it steered carefully clear of indictable conduct.
And for what it's worth, I suspect he is leading with his chin on Freddie and prescription drugs. The Democrats are already out with a story about how, while Mitt has been publicly pummeling the mortgage giants, he has been privately investing in them, at a handsome profit, through a mutual fund. I heard Newt mention this story in an interview this morning, and I imagine that will be a regular topic for the next couple of days. I doubt it's anything most of us would much care about … except that Mitt has chosen to make Newt's Freddie connection a big deal.
As far as Bush's Medicare Part D plan is concerned, conservatives are going to be a lot less concerned about whether Newt lobbied for it than about how the various candidates stand on it as a matter of policy. Many of us believe that, notwithstanding some positive elements (which James Capretta describes here), it was wildly irresponsible to add a new entitlement program — one the comptroller general called "probably the most fiscally irresponsible piece of legislation since the 1960s" — to the Medicare entitlement program whose costs were already out of the stratosphere.
Newt's negatives are well known, and they are being very effectively highlighted by conservative journalists, Romney surrogates, and members of Congress who served while Gingrich was Speaker (including Ron Paul last night). Romney makes himself seem small by focusing on them. He also looks very uncomfortable doing it — it's not him. Mitt needs to focus on improving the conservative case for Mitt.


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Skip to comments.Freeper Harry Clark (The Other Harry) has passed away
Posted on 08/09/2005 8:30:33 PM PDT by Jim RobinsonEdited on 08/10/2005 1:00:24 AM PDT by Jim Robinson. [history]
I just received an email message from a long time friend of Harry Clark. She says he passed away yesterday at his home in Virginia. She also says he will be greatly missed for his quirky sense of humor and quick mind. If you got past his superficial BS shell, he was a wonderful person.
He will be greatly missed.
Do you have any info on Harry that can be posted?
Oh Jim! Prayers for The Other Harry's family!!!
Prayers up for his family.
Prayers for his family.
I don't think I ever came across The Other Harry, but I sure pray for eternal peace for him and comfort for his loved ones.
Good grief. Prayers for him and his family.
Prayers for Harry's family & friends.
Prayers of comfort and peace for Harry, family and friends.
I've seen his screen name, but I don't remember if our paths crossed. Does anyone know if he was sick? He just posted, a day or so ago!!
Condolences to the family. RIP dear man.
Here is the info from Harry's profile page:
The Other Harry
Since Nov 25, 2000
Male, age 56. Moved from Santa Cruz, California, to a small town in central Virgina in November 2001. No regrets. It felt good to say goodbye to California.
Virginia is a very nice state. Lots of nature, conservative / libertarian politics. You can literally buy a house here for $150,000 that would cost over $600,000 in Santa Cruz. And it's pretty hard to get a parking ticket here. If anything, our community services are better here than they were in Santa Cruz. Excellent library, wonderful park, nice people at the city offices.
I blew out of EMT training last year. That's Emergency Medical Technician. It was a little more intense than I was prepared for.
I'm trying to decide what to do next. I might go work in a law library. Either that, or as a volunteer at the Wildlife Center of Virginia.
Finally, I am looking around for a church. I think maybe the Mennonites. They are pacificsts, but I like them. There is also a nice independant chuch approximately across the street from me.
My politics are a mix. I am mostly libertarian. I'm quite a bit conservative, but I am very frustrated with the Republican party. If they truly believe in smaller goverment, I don't see the evidence of that.
There is some Democrat in me.
Oh dear, just last week he was wanting to buy a horse so some kids could ride. Rest in peace Harry.
I join in prayers for Harry's loved ones - God's peace, blessing and guidance - as they deal with his homegoing!
I recognize the name. Prayers and condolences to the family. I wish we could pay tribute to Freepers while they were still alive. Kind of living eulogies?
Heart felt condolences to his family.
Rest in Peace
RIP, The Other Harry.
Our sympathy and prayers to Harry Clark's family and friends.
"TT", Beth & Nana
You will be missed Harry. God Bless ya.
Rest in Peace Harry Clark (The Other Harry)
My prayers go up for the friends and family who now mourn his passing.
If you want on/off my prayer ping list, please let me know. All requests happily honored.
Prayers sent for his loved ones.
RIP. I remember the "other" Harry fondly. 56 is too young for this. Condolences to the family.
Prayer BUMP
Hi BG....I though I'd look you up...fyi, there's a huge fire burning at a chem plant in Romulus, Michigan....
Prayers sent for Harry's family and friends.
prayers for Harry's family.....may God comfort you in your loss and bring you peace...
Godspeed Harry and bless you. Prayers for peace for your family.
I found myself looking forward to Harry's next vanity the last couple of weeks. He seemed like a unique and good man. Prayers for his family.
Prayers for his family and friends on this sad day.
how very sad...
Ah, the altruistic essence of FR. No need to fear the facts, but always fear the wit of other Freepers. They are the only ones that can outsmart you just as you think you're smart, if only for a second.
May God bless you, TOH.
Although I didn't know him at all...may he rest in peace...and God bless his soul.
Rest in Peace....and prayers for The Other Harry's family.
Many prayers for the family.
RIP. Prayers for his family and friends.
When a good conservative passes on it means big trouble for any liberals who somehow lurk on the other side. Somehow I think that's light work.
Godspeed, Harry!
Prayer bump
Very sad news indeed. He was too young to die. Condolences to his family.
Prayers offered.
I remember that thread.
Rest in peace Harry and condolences to the family.
I remember Harry
Prayers for his loved ones.
Very sad news, prayers for TOH and his family, and thanks for posting this news, albeit sad.
Prayers up for loved ones left behind.
I did not know him........
But adding my prayers for the family.
condolences to his family
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
Vancouver, BCCanada
November 14, 2012
Absolutely, how could they not be?
Saw some strange light hover over a mountain top in Hope, it would dip below the mountain top, rise up again slowly like a rising star or sun, hover again for a few minutes, did this repeatedly for 5 or so minutes than took off at a great speed off into the night sky, freaked me out but intrigued me all at the same time .
There is a small # of vety rich families that are running the world's governments for their gain and the rest of us are just paw s,and peasants, not to mention the hiding of UFOs knowledge and abductions.
Hi me and my Husband are interested in the group topic and looking to meet like minded people.
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text:
Others are planning on the university of the future, and most aren't going to like it.
September 30, 2016
A new report from the Council of Economic Advisers details how the Obama administration's higher ed policies over the last seven years have begun to pay off, write Sandra Black and Jason Furman.
September 30, 2016
A major criticism from students who have dropped out of graduate school is the lack of support they received from their professors, write Melissa A. Brevetti and Dana Ford.
Recent Columns
September 29, 2016
September 29, 2016
Cognitive dissonance made me do it. If you want social justice, why do you let your research be locked up for profit?
September 29, 2016
Rochester, a reference, the reason for scholarships.
November 13, 2008
Beverly Daniel Tatum considers why, as so many students rejoice in the election of Barack Obama, some campuses are experiencing racial incidents linked to the election.
November 12, 2008
The late John Leonard was a one-man cultural-studies symposium. Scott McLemee reminisces...
November 11, 2008
As Measuring Up 2008 prepares to grade higher education progress on a variety of fronts, most states' efforts to gauge academic outcomes have stalled, writes Peter Ewell.
November 10, 2008
Academics may need a reality check about what may and may not be possible in the new administration, writes Arthur Levine.
November 7, 2008
Mice in a maze and little people: for many (especially faculty) who work in higher education on any number of campuses, this might seem an appropriate appellation for the characters in Spencer Johnson's Who Moved My Cheese? The theme of this brief book, studied as illustrative text in many leadership and change courses taken by administrators chasing after an Ed.D., is to read the writing on the proverbial wall and embrace change.
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Mite, Mini-mite, Termite, 8U, 6U and Rookie Mite levels CLOSE on Oct. 9, 2016.
Registration for Bantam, Peewee, 12U, Squirt and 10U = CLOSED.
All information needed to register can be found on the Season Registration Page.
Click the image to the left to go directly to the 2016-17 Season Registration.
Link to the Volunteer/Dibs Registration is at the left and on the Volunteering homepage. Please complete this registration after you have completed your season registration. THIS MUST BE COMPLETED EACH SEASON.
We are proud to announce that LETTERMEN SPORTS will be partnering with CCHA for apparel this year.
Lettterman Sports has all the brands you like plus lots of new products and styles... including girls specific designs and youth sizes for lower level players and siblings!
In addition to all new selections, all ordering will take place through Lettermen's CCHA on-line store. We will offer four ordering opportunities, an option to ship your order directly to you or you have the option to pick up from Lettermen's Plymouth store location.
CCHA will also host a sampling try-on event in which you will have the opportunity to try on any sample sizes during the Mite tryouts at the Victoria Rec Center on Saturday, October 22nd & Sunday, October 23rd.
Team packages and custom team orders available! We are strongly encouraging all teams to order their apparel through our partner.
CHASKA MOUTHGUARD DAY! -- Saturday Oct. 15, 2016
Don't miss the opportunity to get a FREE CUSTOM MADE MOUTHGUARD courtesy of:
Chaska Orthodontic Specialists
Dr. Doug Vayda and Dr. Mark Holmberg
1475 White Oak Dr.
Chaska, MN 55318
Please join us Saturday October 15th, We are located next to the Holiday gas station on Hwy 41 and Engler Blvd. We will be taking impressions from 8:00 am -11:45 am. Please try and come in your allotted time slot. If you can not make it during that time you are welcome anytime between 8:00 am -11:45 am.
If your child has braces we can not make a custom mouth guard for them, for they fit too snugly, the mouth guard would pull their braces off. We have boil and bites available in this case.
The coaches will distribute the finished custom mouth guards back to the hockey players.
Boys and girls age 4-9 can try hockey for free on the following dates at the Victoria Rec Center! No commitment. No pressure. All they need are a pair of skates and a helmet. Full equipment sets will be available to borrow on a first come, first serve basis. Equipment fitting starts 30 min. before the event.
|Oct. 15
|9:30 - 10:30 am
|Vic. Rec Center - East rink
|Nov. 12
|9:30 - 10:30 am
|Vic. Rec Center - East rink
Questions? Contact Keri Mack at firstname.lastname@example.com or Josie Colleran at firstname.lastname@example.com
In an effort to promote a standardized uniform for CCHA players, the CCHA board approved a policy to standardize player equipment colors. Beginning with the 2017-18 season, all CCHA players on the "Upper" levels (Squirt/U10, Peewee/U12, Bantam/U15) will be required to wear black helmets, gloves and breezers (or shell). In providing one year advance notice of this change all players are encouraged to begin the transition of non-compliant equipment this year. These requirements do not apply to Rookie, Termite, Mini-mite, Mite or 6U/8U teams, however we encourage all players to purchase black equipment when possible.
Volunteer shifts for Tryouts are posted. You may not work a tryout shift for a level that your player is skating.
In order to sign-up for a Dibs session, you have to be registered in the Volunteer/Dibs Registration. This registration should only be completed once for each family.
Click on link above to create your Volunteer/Dibs Profile if you haven't yet. This is separate from the season registration and is necessary to track volunteer responsibilities per the CCHA Volunteer Policy.
Registration is open for the 29th Annual Brick City Tournament
Squirt B, C and PeeWee C teams
Nov. 25th - 27th, 2016


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Crayola 12ct Watercolor Colored Pencils
Product Actions
BUY ONLINE PICK-UP IN-STORE now available in a store near you.
Pick-up in one of our locations near you.
Additional Information
Crayola Watercolor Colored Pencils turn pencil drawings into bold watercolors! Use with a wet brush, as a wet pencil or use on wet paper. Or use dry like a traditional colored pencil.
- 12 thick pre-sharpened pencils in rich, vivid colors
- Crayola Colored Pencils are made from reforested wood. For every tree used a new one is planted. And we never use rain forest woods or endangered species.
- AP Certified nontoxic
- Handling Code:
Items shipping from our warehouse ship within 3 business days (Mon-Fri) for standard shipping. If an order is placed on Friday, Saturday or Sunday, it will ship out within 3 business days the following week. Items shipping direct from the manufacturer will take additional processing time and ship separate from the remainder of your order. See our Full Shipping Policy >
|In-Home Arrival Estimate
|6-9 Business Days
|3 Business Days
|Express Plus
|2 Business Days
For pricing information, please see our shipping table, shipping prices are based on order total.
If you aren't 100% satisfied with your order, you can return it to us for a refund within 90 days of delivery. To make returning an item easy, we offer a return shipping label with most shipping packages or you may ship the package back on your own. If you use our shipping label, you will receive a refund back to your original payment method, minus a $5 shipping fee. See Full Return Policy >
Personalized products can not be returned. Every order is custom printed for the person who ordered it and therefore can not be resold. If you received product that was flawed or damaged, we will be happy to work with you on a case by case basis. Please call 888.739.4120, Mon.-Sat. 9am-7pm EST, to determine return eligibility & process.


text: Home > Lifestyle 'Sadako The Ring 3' coming to PH ABS-CBN News Posted at Jul 30 2012 04:22 PM | Updated as of Jul 31 2012 12:22 AM Share Facebook Twitter GPlus LinkedIn Pinterest MANILA, Philippines – Sadako of hit Japanese horror film "The Ring" is set to hit selected Philippine cinemas next month. Local mall giant SM will have exclusive rights to "Sadako The Ring 3," which will premiere in the country on August 8. The film was originally titled "Sadako 3D," and was released in Japan last May 2012. Reports said there is no available 3D format with English subtitles; thus, the Philippine release will only be on 2D. SM provided a synopsis of the "Sadako The Ring 3," which is marketed as "the final chapter to the most terrifying ghost story ever told." "Akane is a high school teacher who hears a rumor from her students that there is actual footage on the Internet of someone's suicide. The footage is said to drive anyone who sees it to also commit suicide. "Akane does not believe the rumor at first, but when one of her female students dies after viewing the footage, she and her boyfriend Takanori are fatefully drawn into the horror that has been created by the man who appears in the suicide footage, Kashiwada. "Kashiwada's intention is to create chaos in the world by bringing back Sadako and the power of her curse. Now Akane has to fight against Sadako and Kashiwada to save the lives of herself and Takanori." "Sadako 3D" is based on the novel "S" by the creator of "The Ring," Koji Suzuki. The film stars Satomi Ishihara, Koji Seto and Tsutomi Takahashi. Below is a trailer of the film. Share Facebook Share on Twitter GPlus LinkedIn Pinterest Read More: film movies The Ring sadako /entertainment/09/25/16/charo-santos-speaks-up-on-kris-aquinos-move/sports/09/25/16/racela-dennison-question-disqualifying-foul/business/09/25/16/labor-leaders-launch-anti-contractualization-alliance/business/09/25/16/palace-urged-penalize-agencies-for-failure-to-cut-red-tape/entertainment/09/25/16/watch-hashtags-pack-kia-theater-for-concert


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Jay-Z's foray into the world of being professional sports agent has had a few consequences. For one, it caused old white baseball agents to make horrible rap jokes. And it also has made him decide to begin selling his stake in the Brooklyn Nets.
No one, including Californians, wants to see the Kings stay in Sacramento
Over 30,000 people from all over the US have chimed in on Sportsnation's poll on what should happen to the Kings. And as you can see, everyone wants to see the Kings move to Seattle. Even Californians. Which obviously makes total sense.
While Chris Bosh was celebrating his birthday, his house was robbed of $340K worth of valuables
NBC6 in South Florida is reporting that while Chris Bosh was out celebrating his 29th birthday on Wednesday night, his house was robbed. According the report, Bosh was out celebrating at Briza on the Bay on Bayshore Drive in Miami on Wednesday night. And when he arrived home, he found that his home had been […]
Mark Cuban says he would consider drafting Brittney Griner
Mark Cuban loves to talk. Not only does Mark Cuban love to talk, he loves to say things to rile people up. And he's pretty good at it. Case in point, the reaction that his comments about drafting Baylor star Brittney Griner has received.
Last night's Bucks-Bobcats game began with Larry Sanders elbowing referee Bill Kennedy in the head
We're pretty sure you didn't get to see the Bucks take on the Bobcats last night. Likewise, referee Bill Kennedy almost didn't get to see the Bucks take on the Bobcats last night either. Because just seconds after throwing the ball up for the opening tip, Kennedy was sent to the court after being hit […]
The Miami Heat just proved that you can indeed rest your players and not get fined
Back in November, David Stern got his panties in a bunch because Gregg Popovich decided to run his team the way he wants to them run. And by that we mean that he sent Tim Duncan, Tony Parker, Manu Ginobili and Danny Green back to San Antonio prior to their nationally televised showdown with the […]
Andre Drummond airballed two straight free throws last night
Andre Drummond had a tough time shooting free throws during the Pistons' 95-94 loss to the Bulls. Drummond went 0-3 from the line, which on its face isn't all that bad. But when you add that two of those three missed free throws were airballs, then it's bad. And then you add in that those […]
Dwight Howard says he and Kobe Bryant aren't best friends, but they're now on the same page
The issues between Dwight Howard and Kobe Bryant have been well documented around these parts. But lately, the two have been on a crusade to downplay their issues. Kobe says the media has manufactured the issue and now Howard claiming that there really aren't any problems between the two.
Cleveland fan runs onto the court, shakes LeBron James' hand
In the middle of a 48-14 run where the Miami Heat came back from a 27 point deficit, a fan decided that it was time for him to get involved. So he ran out onto the court wearing a t-shirt with a special message for LeBron James.
A Philadelphia radio station has created a 'Get Out Soon' card for Andrew Bynum
The WIP Morning Show is done with Andrew Bynum and his knees. So when Sixers head coach Doug Collins said he hopes "we all keep [Bynum] in prayer "and that even though he hasn't played all season that he's still a 76er", show host Angelo Cataldi lost it. So in response, Cataldi created a "Get […]


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Love the walk and the views specially that we were eating mangos all day you just pick them along the road extremely sweet
This is such a beautiful place. You may go snorkeling and see tortoises (although beware of strong currents) and the view from the top is incredible. A whole picture of different blues.
Great place for snorkeling, beautiful sea colors, you can see very nice and exotic species just there. The locals working on the Cay are friendly, more than the ones at the island (Providence).
This is a great place to snorkel and kayak around and see the different blues of the Caribbean Sea, but be aware it can be really expensive: boats there are quite expensive, rent kayaks is not cheap either and once you get there you have to pay another entry fee. I recommend to rent a kayak (if you negotiate you... 更多
It is a must go if you are in providence. U can get there by boat or rent a kayak, you can also rent snorkell equipment at the cay. It has the most amazing views I've ever seen.
View from the top of the cay is amazing. Snorkeling around the island is nice, it is possible to see turtles if you are lucky. Accessible by kayak our boat, arriving there they charge com 16.000 (5 dollars)per person to access the cay.
If you want to really enjoy the sea of the seven colours, Crab Cay is definitely the place to go. The views from the top of this rocky isle are amazing! Snorkeling around is pretty nice, too. Beware of the high "entrance" price. There is only a small bar with coco locos, no other facilities. There are boats right at... 更多
This is one of teh most beautiful spots in the island. The water at Crab Cay is so crystlline and beautiful! You can do snorquelling there and you get to see turtles, lot of fishes, small manta rays. Its MUST!
Go early in the morning or late in the afternoon to avoid crowds. Bring money (16,000 pesos for extranjeros) as you must pay to sit on the dock.
Spectacular view from the top of the rock. The snorkelling wasn't amazing, although it was decent. The boatmen charge ridiculous prices for the 2minute boatride and kayak rental is also extremely expensive, so I just swam out, it is about 1km. The boatmen don't like this and may tell you it is not allowed, but just ignore them and keep... 更多