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Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women
A recent report of the EuroHeart project has shown that women are still underrepresented in many cardiovascular clinical trials, while important gender differences are present within most areas of heart disease. As the burden of cardiovascular disease is increasing in middle-aged women relative to men, a more profound understanding is needed of the fundamental biological differences that exist between men and women. In the current review, we aim to address the need for more explanatory sex-specific cardiovascular research to be able to adapt existing guidelines for a better heart health in women.
- Atherosclerosis
- Gender
- Hormones
- Risk factors
- Women
Cardiovascular health needs more female-specific attention
The economic burden of cardiovascular disease (CVD) in Europe is progressively expanding with an increase in the incidence of obesity and diabetes, due to low adherence to a healthy lifestyle and poor control of CVD risk factors.1 The risk of heart disease in women has been underestimated in the past due to the misperception that females are 'protected' against CVD.2 Although clinical manifest CVD develops 7–10 years later in women than in men, it is the major cause of death in women older than 65 years of age (Figure 1). According to the latest World Health Organization (WHO) statistics the burden of CVD will increase further to 2030 and a large part of disability-adjusted life years (DALYs) will involve inhabitants of the Eastern and Central European Countries and in the developing countries such as Asia, Latin-America, and the Middle-East.3 In Figure 2 world-wide DALYs in women >45 years are represented according to diseases and income level. Recent data from the National Health and Nutrition Examination Surveys (NHANES) have shown that over the past two decades the prevalence of myocardial infarctions has increased in midlife (35–54 years) women, while declining in similarly aged men.4 Parallel with the rise in blood pressure and cholesterol levels after menopause there is almost a doubling in the prevalence of stroke among middle-aged women. As was demonstrated across Europe in the EUROASPIRE III survey, modifiable lifestyle factors have aggravated and especially young women have taken up smoking habits and women have a higher increase in the prevalence of diabetes and hypertension than men, with its consequences for CVD incidence and prevalence.5
In the report from the European Heart Health Strategy (EuroHeart), it has been concluded that women are currently still underrepresented in research in many important areas of cardiology.6 The mean percentage of women enrolled in cardiovascular clinical trials since 2006 was 30%, while only 50% of trials reported results by gender analysis. The latest US guidelines on CVD prevention in women include recommendations that are based on research conducted predominantly in men.7,8 Less evidence-based preventive, diagnostic, and therapeutic options for women with CVD may lead to under treatment and a lower quality of care in comparison with men. Moreover, female-specific issues related to pregnancies and hormonal changes during menopause are important in the occurrence of CVD throughout a women's life and will need more attention.9 The many biological differences that exist between the sexes, from basic research to responses on medical therapies, are important within the whole range of CVD and translates into socio-cultural behavioural differences ('gender') between men and women. A therefore more gender-specific approach to CVD is needed with specific attention to cardiovascular health in women.10 As it was emphasized in the conclusions of the EuroHeart project, this will need commitments from a broad range of researchers, medical practitioners, and European policy makers.6
Key questions concerning gender differences in cardiovascular disease
Ischaemic heart disease and stroke
Sex differences in the pathophysiology of atherosclerosis and vascular dysfunction
Combinations of inflammatory and thrombotic processes are involved in the progression of atherosclerotic disease in both men and women, whereas the role of endogenous oestrogen status in delaying the onset of atherosclerosis in women is still under debate.11–13 Inflammatory diseases, such as rheumatic disorders, are more prevalent in ageing women compared with men and may be more involved in the progression of atherosclerosis in females.14 Although atherosclerotic plaque composition changes throughout menopause transition and women have more inflammation in the coronary arteries than men, it is hypothesized that the progression of atheromas into more vulnerable plaques develops slower in women at middle age with a more diffuse pattern of atherosclerosis and outward remodelling.15–17 Plaque erosions are often seen in women with acute coronary syndromes (ACSs) at younger ages, while in men and older women the classical pattern of plaque rupture and subsequent thrombus formation is more common.18 Plaque erosions may further lead to distal embolization of microemboli and dysfunction of the microvascular coronary system. Women exhibit ACS with open coronary arteries more frequently than men.19 Further, microvascular dysfunction leading to subendocardial ischaemia in the presence of open coronary arteries may play a greater role in women than in men.20–22 In the carotid arteries, women also have a lower atheroma burden and more stable plaques than men, which may explain their more favourable outcomes for conservative treatment in symptomatic carotid stenosis.23,24 The gender differences in atherosclerotic disease progression at middle age are yet incompletely understood and will need more exploration to be translated into clinical practice.
Gender differences in cardiovascular risk factors
Data from the INTERHEART study indicate that the lower ACS prevalence among women at younger ages (<60 years) is largely explained by a lower risk factor burden.25 Although women and men share most classic CVD risk factors, the significance and the relative weighting of these factors are different.26,27 Smoking has a particularly harmful effect in young women with a 60% increased risk for ischaemic heart disease (IHD) when compared with men.28 This was not confirmed however in the INTERHEART study, possibly due to socio-cultural behaviour differences in various parts of the world. With the increase in smoking rates in younger women, not only in Europe but also in the developing countries, reinforcement of healthy lifestyle behaviour in these vulnerable age-groups becomes more important. Systolic blood pressure rises more steeply in ageing women compared with men.5,29–31 Hypertension is more prevalent in older women than in men and strongly associated with their higher prevalence of strokes, left ventricular hypertrophy, and diastolic heart failure (HF). But even moderate or borderline hypertension (<140/90 mmHg) causes more endothelial dysfunction and cardiovascular complications in females than in men.32 Type 2 diabetes has a greater risk for cardiovascular complications in women than in men. In a meta-analysis of 37 prospective cohort studies, the risk of fatal IHD was 50% higher in women with diabetes compared with men.33 The reason for this higher mortality is multi-factorial and related to a heavier risk factor burden, more involvement of inflammatory factors, a more diffuse atherosclerosis throughout the coronary arteries, and more small vessel disease with an often less aggressive treatment of diabetes in women.34,35 Further, especially in women it has been shown that type 2 diabetes is a potent, independent risk factor for HF which cannot be fully explained by coexisting cardiovascular risk factors or previous myocardial infarctions.36,37 At younger age, the prevalence of hypercholesterolaemia is lower in women compared with men, but above 65 years of age mean LDL-cholesterol is higher in women.38 Hypertriglyceridaemia and low HDL-C are more important risk factors of CVD for women than for men.39 It has to be further explored whether targeting of these lipid abnormalities may be useful in women at elevated risk. When focusing on gender aspects of the metabolic syndrome (MetS), the relative risk of insulin resistance, hypertension, and elevated hs-C-reactive protein levels is higher in women than in men.40,41
Female-specific risk factors
It has been thought for decades that the oestrogen drop during menopausal transition induces increased post-menopausal CVD risk in women, probably through harmful changes in CVD risk factors. Healthy women with a more rapid transition through menopause show a higher rate of carotid intima-media thickness progression.42 Women with an early menopause (<40 years) have a 2-years lower life expectancy compared with women with a normal or late menopause.13 Circulating oestrogens do have a regulating effect on several metabolic factors, such as lipids, inflammatory markers, and the coagulation system. They also promote a direct vasodilating effect through the α- and β-receptors in the vessel wall.43 Oestrogen causes vasodilatation by a rapid (5–20 min) activation of nitric oxide synthesis in endothelial cells. The logical consequent hypothesis that replacing endogenous estrogens by exogenous estrogens in post-menopausal women would decrease CVD risk, supported by many observational studies, could not be proved in large randomized trials.44–46 In contrast, hormone therapy (HT) has been shown to increase CVD event rate in older (>60 years) post-menopausal women and its use is not recommended for the primary and secondary prevention of CVD.47 Many hypotheses have been raised to explain the discrepant findings between observational and experimental studies, such as the age of the women and the health status of the endothelium at HT initiation. Healthy endothelium is sensitive to oestrogens, whereas endothelium damaged by atherosclerotic disease is not.48 Hormone therapy increases brachial artery blood flow in healthy post-menopausal women but not in elderly women and in women with multiple cardiovascular risk factors or manifest CVD.49 As an alternative explanation, it has been postulated that early onset atherosclerosis per se may be more important determinants of menopausal age, either through direct damage to the ovarian vasculature or indirectly through an adverse impact on the endocrine system.50,51 Recently, it has also been suggested that vasomotor symptoms (VMSs) during menopause may be crucial for sensitivity to beneficial effects of HT.52 Vasomotor symptoms have now been shown to be associated with a worse cardiovascular risk profile and also with increased coronary heart disease risk but more data are needed to evaluate this hypothesis.53,54
Although several studies have demonstrated that hormonal dysfunction in pre-menopausal women, and in particular the androgen excess as present in women with polycystic ovary syndrome (PCOS) is associated with an increased risk of atherosclerosis and IHD events, it is still unclear whether the PCOS is an independent risk factor for atherosclerosis.55,56
Evidence is increasing that pregnancy may be considered as a 'stress-test' for future CVD risk. Hypertensive disorders in pregnancy have been shown to be predictors for hypertension and CVD events.57,58 Women with a placental syndrome in combination with poor foetal growth or intrauterine death are considered to be at the greatest risk.59 Further, an impaired glucose tolerance during pregnancy and gestational diabetes are female-specific risk factors for the development of diabetes and the MetS in relatively young women.60,61 The obstetric history is not yet included in the guidelines for CVD prevention in women, but a healthy lifestyle after index-pregnancy is recommended.7,62 Thus far, most female-specific risk factors are not included in the guidelines for CVD prevention in women, as their causative impact on women's risk and their added predictive value to the current components of the guidelines are still not elucidated.
Gender differences in psychosocial factors
Observational studies indicate that psychological factors strongly influence the course of IHD.63,64 Coping with stress and emotions as well as depression and anxiety disorders are more associated with elevated CVD risk among women than men. Alterations in autonomic function, as measured by heart rate variability, have been associated with prothrombotic changes in women with IHD.65 Women more often have a lower socio-economic status than men that negatively affects a healthy lifestyle behaviour and the occurrence of obesity and other cardiovascular risk factors. The combination of work and marital stress has also been associated with an increased risk in CVD events in females.66 The acute stress-induced cardiomyopathy (Tako-Tsubo) is more than nine times prevalent in older women than in men and may occur more frequently than it is currently diagnosed.67,68 The aetiology of this syndrome is still unknown, but depression and anxiety disorders may play an important role.69 A lower social support after CVD events affects prognosis and health status particularly in women.70 On the other hand, group-based psychosocial intervention programmes may improve survival in women with IHD.71 The importance of behavioural factors has been adopted in the latest ESC guidelines for CVD prevention, but a more gender-specific approach to cardiology patients will be needed in education and training of healthcare providers.72
Ischaemic heart disease detection in women
Sex differences in symptom presentation of stable IHD are common in daily practice, but the awareness of CVD health risk in women among healthcare givers is relative low and women are often misunderstood for their symptoms.73 Differences in atherosclerotic disease progression between middle-aged men and women may translate into a more 'atypical' symptom presentation in women when compared with the classical pattern in males.17,74 As the chance of having obstructive coronary lesions increases in ageing women, symptoms of angina pectoris become more comparable with their male counterparts. Women <55 years of age are an important subset of patients with missed diagnoses of ACS at the emergency departments.75 At all ages women present less often with chest pain when having an ACS with more concomitant vaso-vegetative symptoms relative to men.76,77 In the European Heart Survey on stable angina pectoris an important gender bias in the use of investigations and evidence-based medical therapy was found.78 This may be (partially) caused by the limitations of current non-invasive and invasive imaging modalities when applied to women.79–81 Coronary angiography is the golden standard to detect obstructive CAD, but may be less suited in women at middle age because an abnormal vascular reactivity may contribute relatively more to symptoms than the presence of stenoses.82 As was shown in the Women's Ischemia Syndrome Evaluation Study (WISE), additional coronary flow reserve measurements (CFR) may reveal abnormal coronary vasoreactivity in women with anginal symptoms and non-obstructive CAD.83 Further, with the use of intravascular ultrasound (IVUS) an increased thrombotic activity has been found in women presenting with stable and unstable coronary syndromes.84 A more frequent application of CFR measurements and IVUS in females to routine coronary angiography may add to a better understanding of their clinical presentation with anginal symptoms. However, the use of these more advanced intracoronary imaging techniques is merely limited to experienced interventional centres. To improve a more widespread clinical assessment of IHD in women, advanced non-invasive imaging modalities, such as MR perfusion imaging, radionuclide imaging and computed tomographic angiography (CCTA), should be more promoted for focusing on IHD detection in females.85,86
Gender differences in treatment and outcomes of acute coronary syndromes
While in STEMI both genders have equal benefit of early percutaneous coronary interventions, therapeutic strategies in low-risk non-STEMI patients show differences between men and women. In the FRISC II and RITA 3 trials, early invasive strategy of patients with biomarker negative unstable angina or low-risk non-STEMI ACS was proved to reduce mortality in men, but not in women.87,88 Analyses of sex-based differences in outcomes after ACS have revealed conflicting results. In-hospital mortality rates in young women with ACS are significantly higher compared with similarly aged men.89,90 In a recent large meta-analysis of 11 randomized ACS trials, it was shown that sex-based differences in 30-day mortality among patients with various manifestations of ACS are largely explained by clinical differences at presentation and the severity of angiographically documented disease.91 Women with ACS are generally older with more clustering of risk factors that may contribute to their higher risk in mortality.92 Gender bias in treatment and sex-related disparities in vascular flow and structure may further add to this increased mortality. While women with ACS have less extensive obstructive and more diffuse coronary artery disease compared with men, the mortality and event rates in non-obstructive coronary artery disease are higher in women.93,94 This so-called 'gender-paradox' is still incompletely understood. In the WISE study, a combination of elevated inflammatory biomarkers was found to be related to IHD outcomes in women, independent of traditional cardiovascular risk factors.94 Further, women have less collateral flow and CFR and more signs of microvascular dysfunction that may interfere with a worse prognosis.17 After coronary interventions, especially when glycoprotein IIb/IIIa inhibitors are used, women have more bleeding complications relative to men.82,95
Treatment and outcomes of stable coronary syndromes in women
Symptoms of chest pain are more prevalent in women than in men and often lead to recurrent hospitalizations and repeated use of coronary angiograms.17,96,97 However, the prognosis of women with recurrent chest pain without obstructive CAD is less benign than previously considered and strongly depends on the number of cardiovascular risk factors that are present.21,93,97,98 The 5-years IHD event risk of symptomatic women with non-obstructive CAD is almost 50% higher compared with symptomatic women with normal coronary arteries.93 It is therefore important that women with recurrent anginal symptoms are screened for their risk factors and that they are treated according to the latest guidelines for secondary prevention. Concomitant prescription of medications for symptom relief of angina pectoris is equally important, including antiplatelet therapy with aspirin.99 Many women without obstructive CAD but objective signs of ischaemia have endothelial dysfunction of their microvascular coronary system.17,19 The relationship between microvascular dysfunction and epicardial atherosclerosis is yet not fully understood and will need more exploration in the future.
Gender differences in thrombosis
Gender differences in coronary thrombosis are still rather unexplored and involve platelet activity, the coagulation cascade and the fibrinolytic system. At the initial stages of atherosclerotic plaque formation increased functional activity of many coagulation proteins is detectable.100 The interaction of these components may be different among men and women within different age-groups and within various vascular beds.101 In pre-menopausal women platelet activity is less thrombotic compared with post-menopausal women, presumably related to the presence of oestrogen β-receptors on the platelet surface area, and levels of coagulation factors change throughout menopause transition.102,103 Women experience many fluctuations in thrombotic activity in their life-times during menstrual cycle, with the use of oral contraceptives, in pregnancies and after menopause. Genetic polymorphisms in women may interact with circulating oestrogen levels and increase the risk of thrombosis.104 In the Womens' Health Study, it was found that primary prevention of ACS with aspirin in women is not useful <65 years of age, while its preventive effect has been demonstrated in men.105,106 In a meta-analysis of six randomized primary prevention trials, the risk of CVD events was significantly reduced independent from sex.107 However, the benefit was different for men and women showing significant reductions for ACS in men and for ischaemic stroke in women, suggesting differences dependent on various vascular beds. For ADP receptor blockers, including clopidogrel and prasugrel, a meta-analysis showed a less profound reduction in any CVD events in women vs. men, for the combination of aspirin and clopidogrel in comparison with aspirin alone.108 Whether this effect is the result of chance or variation in sex-related biological effects remains uncertain. During atrial fibrillation women who are not using anticoagulants have an almost two times higher intrinsic risk of stroke and thrombo-embolism relative to men.109 This has resulted yet in an adaptation to the most recent European guidelines on atrial fibrillation.110 There are no apparent major differences in recurrent thrombosis or bleeding risk between men and women being treated with vitamin K antagonists. This may for a large part be explained by the dose adjustment based on international normalized ratio. The available data for novel oral anticoagulants including dabigatran and rivaroxaban do not suggest sex-dependent differences in recurrent thrombotic events or bleeding.108 However, these data are still confined to relative short-term follow-up observation. Our understanding of gender differences with regard to antithrombotic strategies in heart disease is currently still limited and will need more exploration to be able to provide more optimized therapy in women.
Heart failure
Gender differences in epidemiology and aetiology
The prevalence of HF in the European population is between 2 and 3% and rises sharply at 75 years of age. In 70- to 80-year-old people its occurrence is estimated at 10–20%.111,112 More than half of all patients with HF are females and given their longer life expectancy the proportion of elderly women with HF will further increase. Women more often have HF with a preserved ejection fraction due to hypertension and diabetes while men more frequently present with systolic HF due to ischaemia and/or previous myocardial infarctions.113–115 These major causal gender differences in HF are still insufficiently recognized in clinical practice. Gender-related issues on HF were even barely addressed in the latest 2008 ESC guidelines.112 Left ventricular remodelling shows differences between men and women: while pressure overload leads to more fibrosis and dilatation in men, women tend to have smaller hearts with more hypertrophy.116,117 Animal studies, as well as measurements in human hearts suggest that the interaction of female sex and oestrogen may prevent the up-regulation of collagen in female pressure-overloaded human hearts.118 More gender-specific patterns in gene expression during progression of HF have been identified.119
Other potential causes for (subclinical) HF in women, such as peripartum cardiomyopathy and LV dysfunction due to adjuvant chemotherapy for breast cancer, remain often unrecognized and will need better surveillance in clinical practice and attention in the guidelines.120–122 Women more frequently have dysfunction of the thyroid than men, but its role in inducing (subclinical) cardiomyopathies is still controversial.123,124
Gender differences in diagnosis, treatment, and outcomes of heart failure
Signs and symptoms of HF may be difficult to interpret in women, especially in obese subjects and elderly females. Tiredness and fatigue are often reported symptoms that may easily be attributed to psychosocial-related factors. In the first European Heart Survey on HF there was a significant under-use of echocardiography, especially in women with a lower adherence to evidence-based medication.125 In the second European Heart Survey, however, an important improvement in the use of diagnostic procedures and medical treatment was established.126 Gender differences in response to HF therapy have been reported: in a post hoc analysis of the DIG-trial in patients with systolic HF, it was shown that digoxin treatment increases mortality in women compared with placebo, whereas not in men.127 In most studies on HF a better survival was demonstrated in women relative to men.128,129 Although women seem to benefit more from biventricular/ICD therapy, they receive less often devices and have more procedure-related adverse events and bleeding complications.130,131 No data are available yet on biventricular/ICD therapy in patients with preserved ejection fractions. In women with peripartum cardiomyopathy, successful new developments with prolactine treatment have been reported.121 The broad spectrum of underlying aetiologies of HF and their different clinical presentation within both genders is a challenge for future research.
Strategies to improve perspectives of cardiovascular disease in women
As CVDs are the most important causes of death in women in the Western world and its prevalence is increasing rapidly in many developing countries, important steps forward have to be established in the coming years to improve cardiovascular health in females. This implicates in the first place that governmental support is needed to put research efforts that are especially targeted for women on the agenda. Additional public health efforts are needed to increase awareness among women and healthcare givers about their CVD risk. More educational programmes on gender-specific aspects of cardiovascular care are needed on the level of cardiologists, gynaecologists, general practitioners, medical students, nurses, and other relevant workers in healthcare.10 Female-specific research and clinical programmes should aim at a more multidisciplinary approach to cardiovascular health in women, such as interaction with gynaecologists, obstetricians, endocrinologists, psychologists, etc. First multidisciplinary initiatives have been undertaken for multidisciplinary risk management in perimenopausal women.132,133 Programmatic efforts may be developed to improve detection or tracking of gender differences in cardiovascular care (e.g. electronic health records tracking gender-specific mortality rates by region or country across diagnostic codes). In clinical studies, measures should become standard to include more women with appropriate steps in study design and analysis. If applicable, inclusion of specific markers of disease in women may be considered with sufficient power for the analysis. The longer life expectancy of women has to be considered when the natural course of diseases is discussed. Recommendations on proposed strategies to improve cardiovascular health in women are summarized in Table 1.
|Governmental support to encourage more cardiovascular research in women
|Public health efforts to increase awareness cardiovascular disease risk in women
|Development educational programmes on gender differences cardiovascular diseases
|Standardized registration of gender differences in cardiovascular care
|More interaction among various medical disciplines involved in women's health
|More gender-specific analysis and higher enrolment of women in clinical trials
|Use of appropriate study designs and statistical tools to detect gender effects
|Improve sensitivity and specificity for symptom evaluation of cardiovascular disease in women
|Provide gender-specific data in all guidelines on cardiovascular disease
|Implementation of gender-specific strategies in clinical practice
Priorities to ameliorations in cardiovascular care for women should be discussed within multidisciplinary teams, with a focus on the greatest threats to cardiovascular health in women that are to be expected in the upcoming years. The growing burden of obesity for instance, will have an enormous impact on the occurrence of diabetes, hypertension, IHD, and HF in women. More efforts should be undertaken to implement existing secondary prevention guidelines in females after coronary events.134 The current SCORE guidelines have comparable limitations to the Framingham guidelines for primary prevention in women and tend to underestimate CVD risk in especially the younger age-groups.72 Improvements in symptom evaluation of IHD and diagnostic strategies in women are needed on the short term as symptomatic females are often misdiagnosed in daily clinical practice. Gender-related differences are also important in other fields of Cardiology, such as cardiac arrhythmias, that we have not discussed further in this paper. With this 'red alert' for woman's heart we aimed to emphasize the need for more specific attention and research on female aspects of cardiovascular care (summary in Table 2).
|Important aspects in women (relative to men)
|7–10 years later onset cardiovascular disease
|More DALYs lost to cardiovascular disease at older age
|Inflammation and oxidative stress
|Lower atheroma burden at younger ages (<65 years)
|Oestrogens involved in plaque composition/vascular function
|Vascular dysfunction and small vessel disease
|ACS with 'normal' or non-obstructive CAD
|More plaque erosions than plaque ruptures at ACS
|Heart failure
|Hypertension and diabetes main causes of heart failure
|Predominant heart failure with preserved LVEF
|Ageing women more LVH (men more fibrosis)
|Changes platelet activity, coagulation factors, fibrinolytic activity related to hormonestatus pre-/post-menopause, pregnancy, etc.
|Bleeding complications after interventions
|Increased risk thrombosis with AF
|Risk factors
|Higher prevalence at older age
|Higher association with strokes, LVH, and diastolic heart failure
|>50% higher CVD mortality
|Diffuse atherosclerosis, higher co-morbidity
|Independent risk factor for heart failure
|Low HDL and elevated TG more related to CVD
|Increase total cholesterol and LDL-C after menopause
|Sex-related risk factors
|Pregnancy-related hypertension and gestational diabetes
|Hormonal dysfunction pre-menopause/PCOS/POF
|Life-style and psychosocial factors
|Smoking <55 years higher risk ACS
|Obesity/physical inactivity
|Lower socio-economic status
|Differences in symptom presentation/communication
|More angina with less obstructive CAD
|Lower sensitivity and specificity non-invasive testing
|Gender differences effectivity/interaction/side effects
Conflict of interest: none declared.
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: email@example.com.


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CHICAGO – It's 3am on Saturday night/Sunday morning on August 20th, and you're just not ready to quit. How about indulging in the 2016 "Abbie Hoffman Died for Our Sins" Theater Festival? The three-day theater marathon is in its 28th edition, and will be sponsored for the final time by the Mary-Arrchie Theatre Company, and hosted by the "Godfather of Storefront Theater," Rich Cotovsky. It all takes place at the Den Theatre, 1333 N. Milwaukee in Chicago (details below).
Portia de Rossi
TV News: Entire Cast, Writers Confirmed For 'Arrested Development' RevivalSubmitted by TimBMartens on January 30, 2012 - 12:17pm
CHICAGO – Ever since the final moments of the last episode of 'Arrested Development' (back in 2006), there have been rumors about a feature film being created for the TV series. Cast members and writers would be asked, "when is this movie coming out?" and responses would usually be "we are working on it" or "it's coming." Now, after six years, those responses may actually be true.
TV News: 'Arrested Development' May Return For New Season, MovieSubmitted by TimBMartens on October 3, 2011 - 7:56am
CHICAGO – Could this be the news fans of the old FOX series "Arrested Development" have been waiting for? Since the final episode of the canceled series aired on February 10, 2006, rumors and hope have swirled around that the comedy series would come back for a full length feature film. Now, the long wait may be over and fans could be getting more than just a movie.
Theater Review: Ellen DeGeneres Brings Laughs, Magic to Chicago TheatreSubmitted by Alissa Norby on June 18, 2010 - 12:41am
CHICAGO – "I like the word 'somewhat'", mused Ellen DeGeneres Wednesday night onstage at the Chicago Theatre in front of what is now her standard roused audience. "Like you can say, 'I'm somewhat gay. But my girlfriend's really gay.'"
Interview: Ellen DeGeneres Takes on Chicago in 'Just For Laughs' FestivalSubmitted by Alissa Norby on June 10, 2010 - 2:47am
CHICAGO – Ellen DeGeneres has always been a woman of many hats. Whether taking a seat as host (or featured dancer) on her Emmy Award-winning talk show "The Ellen Degeneres Show", offering musical insight to hopefuls on "American Idol", or lending her voice to the LGBT community, DeGeneres has become a trailblazer of the entertainment industry.
TV Review: 'Better Off Ted' Deserves to Develop an AudienceSubmitted by BrianTT on December 8, 2009 - 12:38pm
CHICAGO – With their renewal of "Better Off Ted" and "Scrubs," it's clear that ABC is unwilling to throw in the towel and give up on a comedy that's not finding its audience. Before the wonderful arrival of "Modern Family," easily one of the best shows on TV, ABC was not recently known as the place for laughs and there has clearly been a conscious effort to change that including giving the relatively audience deficient "Better Off Ted" another shot at finding a following (as well as scheduling an entire night of new comedy to start the season on Wednesdays).
TV Review: 'Better Off Ted' Could Be Worse But Far From BestSubmitted by BrianTT on March 18, 2009 - 1:57pm
Television Rating: 2.5/5.0
CHICAGO – In a landscape of increasingly lower ratings for quirky TV comedy (talk to the producers of "Scrubs" if you don't believe me), I'm kind of amazed that "Better Off Ted" made it to the air. If "Arrested Development" and everything Andy Richter has ever tried couldn't find an audience, who thought people would be attracted to this left-of-center workplace sitcom? And the fact that it doesn't live up to the potential of its concept means the show's thin chance of survival just disappeared.

subset: commoncrawl


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Carl Grody, LISW-S, specializes in child, adolescent, and family therapy. He's been in private practice since 2010 after spending three years with the Community Psychiatric Support (CSP) Team at Nationwide Children's Hospital in Columbus. Grody is a trained group leader in the Incredible Years parenting program, and he is the family therapy columnist for
Columbus Parent
Grody earned his Master's degree in Social Work from The Ohio State University in 2007. While there, he benefited from an intensive, nine-month family therapy internship at Rosemont Center with two professors from The Ohio State University, Dr. Gil Greene and Dr. Susan Saltzburg.
Grody uses an integrated, strengths-oriented approach that focuses on solutions and positive narratives. He also uses a systems approach, which means involving parents in their children's treatment.
Grody also is a published author. He's published 13 books as well as hundreds of articles for national magazines.
Carl's Latest Blogs
Q&A: How Do I Get My Kids To Apologize?
Q: My child got in an argument during a play date recently, and I made him apologize. He didn't want to, of course, and it was like pulling teeth to get him to do it ...
Squaring Off With Chronic Pain:
A Family Battle
In the first session with a client, I emphasize that there's no right or wrong way to feel. Your feelings are what they are, and nobody can tell you ...
Q&A: Can I Trust My Kids Online?
I want to trust my children with their phones and social media, but I also want to make sure they're not getting in over their heads ...
Check out Carl's new column in
Columbus Parenting magazine:
What You Think You See is What You Get
I stopped for breakfast at a local restaurant recently. I love their freshly made strawberry jam, but when I reached for the bowl, I found packets of a brand-name jam instead ...
The Magic of Boundaries
There are no magic wands. We wish there were, of course. Imagine how easy it'd be to get a promotion or to pick winning lottery numbers or to stop a child's fit in the store ...
Co-Parenting Made, Um, Simple
Sometimes, no matter how hard they try, couples can't make things work. They're left with the uneasy business of splitting possessions, property and often friends ...
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Get an overview of this hotelFamily-friendly hotel with full-service spa and free breakfast
Located near the beach, this family-friendly hotel is within 6 mi (10 km) of Church of San Francesco, Dancing Satyr, and Museum Satiro. Garibaldi Theater and Royal Saint Nicholas are also within 6 mi (10 km).
Hotel Features
A full-service spa, a restaurant, and an indoor pool are available at this hotel. Free buffet breakfast, free WiFi in public areas, and free self parking are also provided. Other amenities include an outdoor pool, a health club, and a bar/lounge.
Room Amenities
All 96 rooms offer free WiFi, balconies, and TVs with satellite channels. Guests will also find minibars, hair dryers, and safes.Information missing or incorrect? Tell us!Opens in a new window
Giardino di Costanza ResortVia Salemi Km 7.10 Mazara del Vallo TP 91026
Hotel Amenities
Hotel Amenities
In addition to a full-service spa, Giardino di Costanza Resort features an outdoor tennis court and an indoor pool. The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. A complimentary breakfast is offered. Public areas are equipped with complimentary high-speed wireless Internet access.
This luxury hotel also offers an outdoor pool, a children's pool, and a health club. Complimentary self parking is available on site.
- Free WiFi
- Turkish bath/Hammam
- Outdoor seasonal pool
- Indoor pool
- Children's pool
- Spa services on site
- Full-service spa
- Spa treatment room(s)
- Restaurant
- Conference space
- 24-hour front desk
- Multilingual staff
- Fireplace in lobby
- Tennis on site
- Bar/lounge
- Elevator/lift
- Wedding services
- Concierge services
- Dry cleaning/laundry service
- Fitness facilities
- Health club
- Pool umbrellas
- Total number of rooms - 96
- Number of floors - 3
- Garden
- Luggage storage
- Beach umbrellas
- Beach sun loungers
- Free self parking
- Outdoor tennis court
- Sauna
- Outdoor pool
- Free breakfast
- Year Built 2005
- Number of buildings/towers - 1
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Indoor pool
- Children's pool
- Free Wi-Fi
- Rollaway/extra beds available
- Outdoor tennis court
- Playground on site
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Television
- Balcony
- Air conditioning
- Blackout drapes/curtains
- Minibar
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Bidet
- Bathtub or shower
- Satellite TV service
- In-room safe
- Rollaway/extra beds available
- Free WiFi
- Cribs/infant beds (surcharge)
Where to Eat
Guests are offered a complimentary buffet breakfast.
Dubbesi - This restaurant specializes in Italian cuisine and serves breakfast and dinner.
Nearby Things to Do
An outdoor tennis court and a health club are featured at the hotel. An indoor pool, an outdoor pool, and a children's pool are on site. Other recreational amenities include a sauna and a fitness center.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Sailing nearby
- Scuba diving nearby
- Water skiing nearby
- Windsurfing nearby
- Hiking/biking trails nearby
- Playground on site
Spa Services
Nakhlah has massage/treatment rooms. Services include massages, facials, body scrubs, and body treatments. The spa is equipped with a sauna, a spa tub, and Turkish bath/hammam. A variety of treatment therapies are provided, including aromatherapy.
- Sauna in spa
- Spa tub in spa
- Massages
- Body scrubs
- Aromatherapy treatments
- Body treatments
- Facial treatments
Hotel Policies
Check-in time starts at 3 PM
Check-out time is 10 AM
Payment types
- Pets allowed for an extra charge of EUR 15.00 per pet, per night
- 1 per room (up to 15 kg)
- Restrictions apply
- For more information contact the property at the number on the booking confirmation
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- A tax is imposed by the city: EUR 3.00 per person, per night. This tax does not apply to children under 10 years of age.
Optional extras
- Pet fee: EUR 15.00 per pet, per night
- Crib (infant bed) fee: EUR 8.00 per night
Hotel Name
- Giardino Di Costanza
- Giardino Di Costanza Mazara del Vallo
- Hotel Giardino Di Costanza
- Hotel Giardino Di Costanza Mazara del Vallo
- Giardino Di Costanza Resort Sicily/Mazara Del Vallo, Italy
- Kempinski Giardino Di Costanza Hotel Mazara Del Vallo
- Giardino di Costanza Resort Mazara del Vallo
- Giardino di Costanza Resort
We should mention
All guests, including children, must be present at check-in and show their government-issued photo ID card or passport. Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation. Children 1 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section).


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Gary Allan on new songs, vocal surgery
When I talked to Gary Allan earlier this week, we covered more ground than was able to fit in the full feature that appears here on Tap Milwaukee. Here is more of the conversation we shared as he waited to make a Monday night appearance on "Late Night With Jimmy Fallon." (Click here to watch his spot on the show.)
As Allan prepares to visit The Rave tonight, he discussed why he thought "Tough Goodbye," the lead song (co-written by Cedarburg native Josh Thompson) from his Billboard chart-topping new album, "Set You Free," would be the first single. He also talked about how a vocal cord operation that he underwent just before recording the album has made him feel like a whole new singer, and his approach to Nashville after spending his early years (starting at 12 years old) playing honky tonks and clubs in California's Bakersfield-inspired country music scene. »Read Full Blog Post
Former Wisconsinite Mark Rylance wins Tony for 'Twelfth Night'
Former Wisconsinite Mark Rylance won the first Tony Award of the night Sunday, for best actor in a featured role for "Twelfth Night."
Rylance, a University School of Milwaukee alumnus, was also nominated for a second award, for leading actor in a play for "Richard III." He lost in that category to Bryan Cranston, who won the Tony for "All the Way." »Read Full Article(2)
The Cheel will serve Nepalese and American plates
A restaurant serving dishes from the Himalayas is due in July in Thiensville, apparently the only such brick-and-mortar restaurant in the Milwaukee area.
The Cheel — Nepalese for eagle — will have its grand opening July 19 at 105 N. Main St. »Read Full Blog Post
Pink Banana plays relationship games in 'The Honeymoon Is Over'
The Pink Banana Theatre Company is calling its 10th annual one-act play festival "The Honeymoon Is Over." But the eight short plays unspooling over this fun, two-hour night feel more like a reprise of last year's festival, aptly named "Game Night."
Once again, Pink Banana is asking why we play the games we do — and what happens when our games grow stale, transforming a relationship's potentially liberating rituals into overly scripted routines. »Read Full Article


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General Motors' plan for bankruptcy includes selling part of the company to the government.
Reuters reports GM wants to sell its healthy assets to another company owned by the government.
The remaining assets would stay in bankruptcy protection.
GM is about $6 billion in debt and the government is giving the company untill June 1 to restructure.
Part of that deadline is reaching a deal with unions but GM says it doesn't expect to be able to do that before May 26.
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|Bullet Weight
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Nothing Special
Review by FLORIDA Gunsmith. (Posted on 10/12/15)
Customer rating:
I had bought a few boxes to try at the local gun shop and used a can since it was marked as sub sonic surpressor ammo.
At the range I also had the 45 ACP version of this ammo. As with the 45 version I noticed zero difference between this ammo and any other loadings from other brands or even the red boxed AE 9mm. It was also very dirty after a few boxes . Would I buy this ammo again? Not at full price and if it's on sale maybe but only if I can't find any better quality sub sonic or even full power 9mm. I found that there was nothing special about this stuff.
I shoot a ton of the American Eagle over the course of a year and their surpressor line is expensive and nothing to write home about as well as being extremely dirty for 9mm.
(Posted on )
1 of 3
Review by Nimbus. (Posted on 9/22/14)
Customer rating:
As a new shooter I wanted to try these out for possibility for lower felt recoil. I felt no difference. I was shooting this with NO Suppressor.
I find this ammo to be pretty dirty in my Glock 19 Gen 4.
There were no reliability issues. It ran just fine.
Accuracy is hard to tell. I ain't the most accurate shot to begin with, but I seem to be more accurate with other loadings.
I would probably pass on this in the future due to how dirty it seemed to be. I am sure I can find less expensive cleaner rounds to hole punch paper with.
(Posted on )
2 of 3
No difference.
Review by James. (Posted on 5/9/14)
Customer rating:
Bought these reasonably priced 9mm rounds to see if they were any lighter on the recoil. If there was a difference it was too slight to tell in my heavy framed tangfolio or my wifes sig 938. No malfunctions.
(Posted on )
3 of 3
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A Good Beginning (And Some Holiday DSP)
A t'ai-chi instructor once told me that he considered ten years practice in the art a "good beginning". By year's end I'll have maintained the pages at http://linux-sound.org for more than ten years, so I feel justified claiming that the site is off to a decent start. However, I have a somewhat suprising 10-year celebration announcement: The next edition of the Linux Sound & Music Applications pages (a.k.a. the Linux soundapps site) will be the last under my control. I'll leave it online in a final condition with all addresses checked and repaired, but my tenure as the site's sole maintainer is over.
If you're not familiar with the site I'll recite its little history. In 1996 I placed online a list of the all the Linux audio-related links I could gather on the net. At that time I scoured the Web, the USEnet newsgroups, ftp repositories, and anywhere else I thought might yield a useful program or utility. I think the first edition of the site (then at http://www.bright.net/~dlphilp/linux_soundapps.html) listed a few more than thirty applications. In the fullness of time the list has grown, and my final edition contains hundreds of valid URLs linking to the great variety of music and sound software for Linux.
In my opinion the site has served its original purpose quite well. I also feel that it's time for some important and overdue changes. While the plain static HTML of the site aspires to "archaic chic" it's just not very attractive, and it's too limited in function. Users today are accustomed to amenities such as embedded search engines, rankings & reviews, and other interactive enhancements. The site is also difficult to maintain, though I'm sure I could relieve some of the burden by employing a few handy bash or Perl scripts. Alas, due to various factors I can't do the work required for any of these additions, so I announced my decision on the Linux audio mail lists, hoping that the community will renew the site's structure and provide a more modern and more useful resource.
There appears to be a consensus among list members that the site needs to stay alive in some form. Many participants have recommended a wiki-based replacement, others have enumerated the known problems with wikis, and some have gone straight into designing prototypes. At this point in the discussion it looks as though some form of wiki will evolve from the current site. Despite its familiar drawbacks the wiki does provide the required service amenities, for users and administrators.
While performing this final round of maintenance I've noticed some applications previously overlooked, and I've been surprised by the activity in some Linux audio domains outside my immediate interests. I've also noted significant trends, some beneficial and some potentially otherwise. I'll comment on those notable trends later in this blog, but not today.
So, after ten years I think the Linux Sound & Music Applications site has made a good beginning. The time is right to retire its current condition, and I leave its next stage in the care of the users and developers in the Linux audio community. I look forward to its evolution.
Some Notable DSP
Figure 1: A surface plot in Dataplore
The DSP page has been updated at http://linux-sound.org/dsp.html. While culling its links I discovered (and rediscovered) some excellent projects. I was pleased to see that the commercial Dataplore signal analysis software is still available for Linux (RPM-only, alas), as are the more general purpose packages from the Ptolemy and Scilab projects. More audio-centric (and Linux-centric) packages are coming from the outstanding CLAM project, a recent recipient of the ACM Multimedia 2006 award for best open-source multimedia project. Other new and notable entries include Chris Cannam's Sonic Visualiser and Stefano D'Angelo's fledgling FreeADSP.
Figure 2: Voice2MIDI, a CLAM-based application
According to its home page, "CLAM (C++ Library for Audio and Music) is a full-fledged software framework for research and application development in the audio and music domain [that] offers a conceptual model as well as tools for the analysis, synthesis and processing of audio signals." The page modestly fails to mention that CLAM is also a very cool project.
I built and installed the CLAM software on my AMD64 machine, then I downloaded and built a variety of example applications. I must note here that CLAM is intended for application development, working with the Qt UI designer to provide a complete environment for developing high-quality sound and music programs. The first tutorial takes the novice quickly through CLAM basics and then develops those basics into a standalone application (via the Network Editor, itself a standalone CLAM application). The process is easily learned, and the user interface so well-conceived you'll be a DSP maestro in a jiffy. Well, not really, and of course the more you know about the subject the sooner you'll get predictable results. But anyone can use the Network Editor, and who could have guessed that designing DSP software would be so much fun ?
Figure 2 shows off Voice2MIDI, a standalone application based on the CLAM development software. The complex process of converting PCM audio into MIDI data depends on specialized audio analysis tools, just like the tools found in CLAM. Voice2MIDI analyzes a monaural soundfile and renders its pitch contour into MIDI note events, a valuable utility for composers. The program works as advertised: I loaded a spoken-word soundfile, analyzed it, then rendered and saved the analysis to a MIDI file. From this point I can edit the MIDI events in the multitudinous ways provided by modern Linux sequencers such as MusE and Rosegarden, creating accompaniments perfectly syncronized (or not) to the original audio. Very cool stuff.
Sonic Visualiser also deserves special mention. Figure 3 displays the Visualiser's inventive GUI, but the program's greatest powers come from its support for Vamp plugins. According to the Sonic Visualiser home page the Vamp system specializes in extracting descriptive information from audio data, and it is the primary analysis plugin format used by Sonic Visualiser.
The program truly emphasizes visualization, with data view formats such as various spectrograms, amplitude waveform, piano roll (for MIDI plot), chronogram, pitch envelope, and power curve. The user scrolls through the views with the Navigate cursor (the pointing hand) and uses the Select tool (the arrow) to make selections within the view. Edits are limited to cut/copy/paste, but the program isn't intended for audio processing. It is primarily a tool for audio analysis and visualization, and an excellent tool at that. Highly recommended for serious research and viewing enjoyment.
Figure 3: Sonic Visualiser running an Aubio plugin
The DSP software list includes some peculiar subdivisions. If you're looking for binaural beat generators (a.k.a. brain-wave modification) you'll want to check out AutoZen, Gnaural, and SBaGen. Image to sound conversion is available via Paul Nasca's HyperMammut, and if you want to know how Kraftwerk got that robotic vocal quality check out Achim Settelmeier's cool Vocoder.
Figure 4: Gnaural
I can't leave the DSP links without mentioning two favorite applications listed in the FFT/Phase Vocoder section. Jesse Chappell's FreqTweak is a realtime FFT-based audio processor with an engaging GUI and the capability of consuming hours of my time. I like to run my guitar into it, perhaps in a chain with the ecamegapedal effects processor or the Tapiir multitap delay, and sometimes I like to use it to apply unique filtering effects to an audio stream. As Jesse notes, FreqTweak is an addictive audio toy that invites experimentation and play, but it is also designed for serious audio work. No matter how you use it, FreqTweak is excellent Linux audio software. An update might be nice (hint), but otherwise the program is just about perfect.
Figure 5: FreqTweak
Professor Øyvind Hammer's Ceres is another favorite, a non-realtime tool for performing a variety of rather bizarre spectral transformations on a soundfile. For example, the screenshot in Figure 6 displays the results of treating a soundfile with such exotic processes as shear, blur, warp, null phase, average peak, and exponentiation. And yes, it sounds as weird as it looks. Ceres was written originally for SGI hardware, but it has a long history with Linux. The first Linux port appeared in the late 1990s, and various developers have worked on it more or less continuously since then. Most recently Kjetil Mattheussen has donned the maintainer's mantle, expanding Ceres with Python support and numerous GUI enhancements.
Figure 6: Ceres
I hope you've enjoyed this random blend of news and reviews. My next entry will profile the Aldrin music composition software and will include an interview with its author, Leonard 'paniq' Ritter. Until then, stay tuned, keep swinging, and I hope you all enjoy a fine and mellow holiday season.
Similis sum folio de quo ludunt venti.
Great work
This article is very informative and illustrative. I followed these instructions and managed to get some extraordinary results. Thanks...
Hi Dave,
I just wanted to say what many others have said on mailing lists that your work on the Linux Sound & Music site has been tremendous and is the reason a lot of people, myself included, have come to learn about all the wonderful tools that exist for Linux. Regardless of what comes next, I think that your site will always be a part of the history of Linux Audio and for one I am grateful. Bravo!
p.s. - As always, your blog articles here absolute gems. Thanks!
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Posted on 17 February 2014
- 18:00
The Enterprise Challenge, set up to teach 11-19 year olds the basic principles of business, gives young people the opportunity to explore what goes on behind the scenes at a Premier League club as they work together to tackle the very real task of how a club can engage with overseas fans.
Through a series of interactive workshops, both in their community group and at White Hart Lane, the Skills team explored the business of running a football club, learning what it takes for Tottenham Hotspur to be successful off the pitch. From advertising to communications, the group engaged in a range of topics, learning skills that aimed to empower them to become successful.
The winning group, all aged 13-17, are current members of the Ledley King supported Skills project. Skills, delivered by Tottenham Hotspur Foundation and supported by players of the People's Postcode Lottery, offers a comprehensive sport and education programme to young people from Haringey aged 12-19 years.
As a reward for their hard work, the group attended Monday morning's first team training session at the Training Centre. Eager to pick up tips on how they could further engage with fans from the USA, the group were delighted to have the opportunity to have a chat with Brad Friedel who offered some words of support to the team.
The successful team will now go on to represent Tottenham Hotspur as they battle it out with teams from the South and Midlands at the Premier League Southern semi-final at West Bromwich Albion in March. Three successful teams will then progress to the national final in London in April.
15 August 2016
With the 2016 Olympic Games in Rio in full swing, young people from the local community were invited to the Club's Training Centre to meet First Team Goalkeeping Coach and Olympic gold medallist Toni Jimenez last week.
28 July 2016
Earlier this week the Club supported Haringey Council's Tottenham Sports Day for local residents, one of a number of summer activities taking place in the community over the coming weeks.
9 June 2016
The Club welcomed young people from across London to its world-class Training Centre in Enfield this week to play in a football tournament aimed at promoting teamwork and positive attitudes.
View mobile site
© Tottenham Hotspur Ltd 2016. All rights reserved.
All photography copyright Getty Images (unless otherwise stated)


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Hôtel Hoche
Address14 rue Hoche CannesSee nearby area
For rates, enter dates/guests
Description provided by property
Located in the heart of Cannes on a pedestrian street, Hôtel Hoche is just a 3-minute walk from the Promenade de la Croisette and 400 metres from the Palais des Festivals. Free Wi-Fi is provided.
The guest rooms offer air-conditioning, a desk and a private bathroom with free toiletries, hairdryer and shower. Some also have a furnished terrace with city views.
Every morning, a breakfast buffet is served at the hotel. Restaurants and shops can be found just 400 metres away.
Guests staying at Hôtel Hoche can walk 400 metres to the beach. Cannes Train Station is a 2-minute walk away, while Nice Côte-d'Azur Airport is 28 km away. A shuttle service can be arranged.
Important information
If you plan on arriving after 20:00, please notify the property in advance. Contact details can be found on the booking confirmation.
Guests can benefit from discounted rates on the public parking. For more information, please contact the property directly.
Services & facilities
- Airport shuttle (surcharge)
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- Free WiFi
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Devs talk multiplayer, King Kong, Wii, Leipzig, and more. Exclusive screens.
1UP: The main character seems to be quite different from what was in the old games. Why did you guys decide to make this shift but retain the Turok name?
JH: The first Turok game on N64 was inspired by the classic comic book series and managed to capture the spirit of those comics while establishing all new characters, an original storyline and a mythology all its own. The result was a fantastic game that captured the imagination of gamers everywhere. We want to take a similar approach with this game, moving it in an exciting new direction while remaining faithful to the spirit of the original property. The main character of Joseph Turok fits in perfectly with this vision, while retaining many of the characteristics that made the original Turoks so compelling.
1UP: Obviously the new Turok is very different from the old Turok, but are there any specific elements from the old games you are bringing back to add some nostalgia? Maybe an Easter Egg or two?
JH: As a big fan of the original games, I'm confident that die-hard Turok lovers will recognize many familiar elements incorporated into this new game.
|While seemingly effective, we're not so sure it's smart to use a flamethrower in a jungle. Just a thought. Click the image above to check out all Turok screens.
JH: Turok was a groundbreaking game when it first came out on the N64, but as the series progressed the enemies became increasingly outlandish and far-fetched. We are pursuing a much more believable vision. We're dropping the gun-wielding dinosaurs and cyborg zombies and going with terrifying creatures and human enemies that use a combination of advanced tactics to hunt you down.
Our initial calculations show that this results in a game experience that is approximately 1.7 billion times cooler. The numbers don't lie!
1UP: In recent years, it seems like King Kong has probably gotten the most credit for being a good dinosaur game. Was there anything in particular from that game that impressed you or that influenced Turok?
JH: King Kong came out after we were well into the design phase for Turok, so most of our ideas were solidified at that point. It was a good game, and we were most impressed by the sense of immersion achieved by stripping away the interface graphics (or HUD), allowing the player to focus on the action without the distraction of game elements like health bars or ammo counts. This was a design choice also reflected in Call of Duty 2, another fine game released at around the same time. It's a very effective approach for first-person games where immersion is such a key to the experience, and after playing these two games we made the decision to implement a damage system that does not use a traditional health bar. We're very happy with the results.
More Shooter Games
- Game:
- Turok
- Platforms:
- Xbox 360, PS3, PC, MOB
- Genre:
- Shooter
- Publisher:
- Touchstone
- Developer:
- Propaganda Games
- ESRB Rating:
- Mature
- Release Date:
- 02/05/2008
- Also Known As:
1UP Editor Score: C+
Average Community Score: C+
People Playing
Players: 68335 Hours: 1351751
Based on last 7 days of Raptr player activity.
Based on 1UP traffic, this game is:
#1,624 of 27,541 on 1UP
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text:
News Corp (NWS) is reportedly in advanced talks to buy a stake - possibly almost 40% - in YES, the cable channel that televises New York Yankees games. News Corp is likely to acquire most of the holding from Goldman Sachs (GS) and Providence Equity Partners. The potential deal is likely to value YES at $3B.
News Corp (NWS) is reportedly in advanced talks to buy a stake - possibly almost 40% - in YES,...
From other sites
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ETF Hub
ETF Screener: Search and filter by asset class, strategy, theme, performance, yield, and much more
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Meet the OC Watchdog's new numbers guy
I am a new staff writer at The Orange County Register and wanted to briefly introduce myself to its readers.
I came to the newspaper from Voice of San Diego, a pioneer in local nonprofit journalism. For the past three years, I have mainly been investigating public safety issues, creating graphics and fact checking politicians.
[caption id="attachment_164094" align="alignleft" width="214"] Keegan Kyle[/caption]
All the stories I wrote for Voice of San Diego are available online. Some of my best work examined a corrupt police officer, a bogus civil rights story, widespread errors in pothole tracking and the merits of an unusual policing strategy that targeted inner-city kids.
Before Voice of San Diego, I wrote about crime and local government for newspapers in Wisconsin and southern California. I briefly worked for the Register as an intern in 2009. (You may recall this story about young voters.)
In Wisconsin, some of my biggest stories found a racial disparity in Milwaukee's pothole patching -- crews waited longer to repair potholes in neighborhoods with more minorities -- and found that coffee shops had been shorting their customers.
Much of my past work has revolved around data and numbers. I'm good at getting public records, compiling them into databases and then explaining what the information tells us. As part of the Register's investigations team, I'll be doing some of the same work here.
For now, I'm beginning to examine a few police-related stories and build connections with readers and sources in the area. If you'd like to suggest a possible story or just set up an introduction, please don't hesitate to contact me.
My email address is firstname.lastname@example.com and my direct line in the newsroom is (714) 796-4976. You can also reach me through Twitter (@keegankyle).
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This theme is quite a challenge in many ways. One I am not a great temple goer, two I have given company to people who think that temple visits are meant to be vacations. So you can imagine I have visited lot of temples all through my growing up years. And continuing now with Hubby dear. I know those are contradictory statements, however these are things that has made me what I am.
Growing up, I have seen two different beliefs, one that begins and ends with daily long hours of prayers and traditional customs. The other that says one does not have to go to temple to pray, or to be religious to be pious.
My parents have never really forced either of their beliefs on me. I have arrived at my own beliefs and stand. However I have been a willing company to all their beliefs and doings. Result is, I have visited lot of temples along with Amma and then with Hubby dear, while still holding on to my beliefs. That has resulted in me gathering much more than what I might otherwise achieved.
Well that's for another post, my beliefs and my spiritual hold can run for pages and this is not really the space to talk about it. Its just that I never do anything in half measures and it goes on to say, these posts were enlightening as much as I could expect.
I am sure many would agree that replicating the same taste of a temple prasadam at home, is almost next to impossibility. Even though what we make will taste great, it still would not be the same.
Ambalappuzha is a small town in the Alappuzha district of Kerala state, south India. The town is noted for its Ambalappuzha Sri Krishna Temple, one of the three important Sri Krishna temples in the state of Kerala.
Ambalapuzha Pal Payasam
Ingredients Needed:
Chemba rice / Basmati Rice - 1/2 cup
Sugar - 1 cup
Milk - 1 1/2 cup
Cashew and raisins - handful each
Ghee - 4 tbsp
A pinch of cardamom powder
How to make Pal Payasam
Wash and soak the basmati rice for 30 mins.
Pressure cook the rice and keep aside.
Heat a non stick pan with ghee, fry the cashew and raisins till it turns golden brown. Keep it aside.
Next add 2 tsp of sugar and keep stirring continuously until the sugar melts and the colour of the ghee changes to brown. The sugar also caramelizes.
Add milk to it carefully and slowly from sideways and bring it to boil.
Once the milk starts boiling add the cooked rice to it and again allow it to boil. Now add the remaining sugar.
Continue to boil till the mixture becomes bit thick.
Now add the fried cashews and raisins and cardamom powder. Mix well and switch off.
Offer as prasadam to Lord Krishna before partaking.
When you are trying to brown the sugar, don't wait for long as it will hard.
Simmer before adding the milk, else it might curdle.
Check out the Blogging Marathon page for the other Blogging Marathoners doing BM


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Piss Splash
- Runtime:
- 7:47
- Views:
- 9714
- Date:
- 3 years ago
- Rating:
- (0 votes) 0%
Bouncing bare assed while pissing
sexy toes
ohh wow your feet are amazing haha very sexy baby got me hard for sure 28 white ***** canada
...And the things a woman can do that a man never could...Simply wow... Takes my breath away. I'm at a loss for words for how fascinating this position and this pee play game is. Very innovative!
Actually worth the $$$. I was ***** at first. Thank you hun, I should have known better, 'cos you never disappoint. :)


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Members of the SEIEVA collaborating group are listed in the online version of this article.
Research Article
Risk factors for and incidence of acute hepatitis C after the achievement of blood supply safety in Italy: Results from the national surveillance system†
Version of Record online: 28 DEC 2012
DOI: 10.1002/jmv.23485
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Medical Virology
Volume 85, Issue 3, pages 433–440, March 2013
Additional Information
How to Cite
Spada, E., Mele, A., Mariano, A., Zuccaro, O., Tosti, M. E. and on behalf of SEIEVA collaborating group (2013), Risk factors for and incidence of acute hepatitis C after the achievement of blood supply safety in Italy: Results from the national surveillance system. J. Med. Virol., 85: 433–440. doi: 10.1002/jmv.23485
- †
The authors have no conflict of interest.
Publication History
- Issue online: 22 JAN 2013
- Version of Record online: 28 DEC 2012
- Manuscript Accepted: 30 OCT 2012
Funded by
- "Sorveglianze speciali" of the Italian Ministry of the Health (Progetto CCM e Istituto Superiore di Sanità-Fasc. ISS 1M56 14/09/2010-13/09/2012)
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product information
Cuisinart's Immersion Hand Blender gives you the power and control you need for easy blending where you need it! Blend soups, drinks, batters and much more. Best of all the blending shaft and jar are dishwasher safe which makes cleanup easy!
- Powerful 200-watt motor can handle the toughest blending tasks.
- Slim stick design can blend in a variety of containers which gives you more options!
- Ergonomically designed grip means you have more control over the blender and you won't get fatigued.
- Two speed blending with a one-touch control design make one-handed use easy.
- Blending shaft and jar are dishwasher safe.
product details
SKU 00355163 model no CSB-75BC product dimensions 2.1 x 2.6 x 14 inches shipping weight 3 lbs brand Cuisinart color brushed chrome material No MFG: product manual N/A MFG: warranty N/A MFG: specs N/A
ratings & reviews


text:
Welcome to The Professional Associates PC website which is designed, not only to provide a profile of our firm and the services we provide, but also as a helpful resource tool for you, our valued clients, and visitors.
Our dedication to professionalism brought us to the internet as just one more way to continue to provide the highest quality client service and guidance.
As you browse through our website, please note that not only have we provided background information on our firm and the services provided, but we have also included useful resources such as informative articles (in our Newsletter section) and interactive financial calculators (in our Financial Tools section). In addition, we have taken the time to gather useful links to external websites that we feel will be of interest to our clients and visitors (in our Internet Links section).
Please make use of the resources on this website and feel free to contact us with any questions, comments or concerns you may have. We pride ourselves on being proactive and responsive to our clients' inquiries, suggestions, and needs and would love to to be of service to you.
Thank you for visiting and please return soon.


text:
CP-SmartSurfacesProject reference: 224880
Funded under :
Towards better point of care devices: Conducting polymers as smart surfaces in biosensors
Project details
Total cost:EUR 100 000
EU contribution:EUR 100 000
Coordinated in:United Kingdom
Call for proposal:FP7-PEOPLE-2007-4-3-IRGSee other projects for this call
Funding scheme:MC-IRG - International Re-integration Grants (IRG)
Discovered just over 20 years ago, conducting polymers (CPs) have gained considerable attention because of their unique chemical and electronic conducting properties. As a result they have various (bio)analytical and technological applications. CPs are easily synthesised, both chemically and electrochemically under mild conditions, opening up vast possibilities for the immobilisation of biomolecules. Immobilisation of antibodies by entrapment within films or by covalent binding on these films permits the straightforward fabrication of biosensors. In electrochemical biosensors, non-specific binding (NSB) of molecules, e.g. proteins in serum, can occur, lowering overall device performance. In the past, surface chemistry has been employed to prohibit NSB on electrodes with sites that do not have antibodies attached. This surface chemistry however, impairs device performance. CPs have inherent dynamic surface properties that can be easily switched upon the application of an appropriate electrical potential. Their ability to be switched between different oxidation states and the associated switch in properties such as doping level, resistance and surface wettability can be controlled by changing the electrical potential resulting in reversible switching. Routes to nano-dimensional CPs, exhibiting markedly improved properties from those of the bulk materials, have been recently developed. We therefore propose to exploit the dynamic chemical nature of CPs to inhibit NSB in electrochemical bio-assays and demonstrate the efficacy of this approach using a simple nanostructured electrochemical prostate cancer diagnostic platform made from conducting polymers. One can imagine the significance of a biosensor that provides increases in performance and shorter detection times, since the immobilising platform, transducer and dynamic surface control are implemented within a single material.
Related information
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Fax: +353 1 7005314


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'Breaking Bad' Star Anna Gunn's 5 Tips for Distracting Herself From the Emmys
After four seasons on AMC's Breaking Bad, Anna Gunn has finally been recognized for her complex, moving portrayal of Walt's slowly crumbling wife Skyler. Fans of the show might not have been surprised to see Gunn's name on the list of 2012 Emmy nominees, but Gunn herself greeted the news with trepidation.
The actual Emmy Awards won't happen until September 23, which leaves over two months between the announcement and the big day for Gunn and her fellow nominees to work themselves into a hypothetical-filled tizzy. Gunn shares with Hollywood.com her top five list of ways to distract herself from the Emmy speculation and stay sane during the next month… or at least try to.
1. Play with Her Kids
"Basically I'm doing things with my kids, playing with my kids, swimming with them. It's a good thing anyway, overall, but it keeps me in the moment and keeps me from projecting myself into the future."
2. Hit the Gym
"Working out is a really good way to de-stress and put my energy into something really active. And I do pilates, I do yoga, I work with a trainer. Bike riding also just always makes me feel good, so I do that alone and with my kids."
3. Go on Vacation
"Going on vacation. I'm going up to San Francisco, just going to do some touristy things with the kids and spend some time with my family up there. I think that will also be a good way to get my mind off of any nervousness."
4. Organize
"When I get into the mood, organizing makes me feel such [accomplishment]. It's such a weird thing! I've been going systematically through my house and there are piles of things in my office that I haven't even looked at or touched in probably a couple of years. Just going through that stuff makes me feel a sense of accomplishment. I'm going room by room; it's spring cleaning, even though it's summertime. It's my version of spring cleaning!"
5. Watch the Olympics
"I've been watching the Olympics when I can, and that really pulls you into a whole different thing. That's been really fun. I got to watch the opening ceremony, which was amazing and epic. And I love the swimming events; obviously everyone is really excited about Michael Phelps and I got to see the 200m race [the other] night. My girls like watching gymnastics with me and stuff like that."
Like the Olympic athletes we have all come to love this summer, Gunn knows that, win or lose, it is the journey of these coming months that she'll remember when she looks back on this year's Emmys. "Bryan Cranston—he's a great leader for all of us in our cast anyway—but he's been through this so many times and his advice is just enjoy the journey, because that's what counts," Gunn says. "It's the stuff along the way and being present in the moment and enjoying every part of it and not sort of thinking just about when the night comes and what's going to happen. And it's really true."
Follow Abbey Stone on Twitter @abbeystone
[Photo Credit: David Edwards/DailyCeleb.com]
'Breaking Bad' Cast Connections: 'Total Recall' and Other Common Bonds — INFOGRAPHIC
Bryan Cranston's Amazing Impression of 'Breaking Bad' Costar Dean Norris — EXCLUSIVE VIDEO
Tio Salamanca Speaks! Mark Margolis on His Emmy Nomination and the End of 'Breaking Bad'


text:
Pokemon Go Outside
Maybe you've seen them – hordes of people walking around in groups, holding their phones up and pointing them at odd places, talking about incense and modules and gyms and a whole bunch of words you don't understand. This is Pokemon Go – and it has apparently taken over the entire world. As someone who falls into the age bracket of…read » July 14, 2016


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Ticket Package to SP Style Anniversary Blowout
Mill City Nights • Minneapolis, MN
Saturday, December 21
What you get
- Ticket Package
- All Star Radio Mixtape Release featuring Absent, Xplycyt, Marx, and S.Madison
- Special Guests: Vintage Cloth (Mike the Martyr and Big Wiz), RARE, and Go MJ
Hosted by Shadyville DJs Peter Parker with DJ D.Mil, the SP Style Anniversary Blowout brings together some of the best local hip-hop talent for a night of fun. Catch all the action at Mill City Nights on Saturday, December 21 when Absent, Xplycyt, Marx, S.Madison, and more take the stage to wow the crowd.
$26 for a ticket package, including:
• One GA ticket (standing room only)
• $10 bar voucher
• One show poster
• One coat check item
Find out more about SP Style Anniversary Blowout
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss an event. In the event of a cancellation, your voucher will be fully refunded • Each voucher is good for 1 person • Must be 21+ with valid ID to drink alcohol • The deal is valid on event date only • Purchaser must pick up ticket(s) at Will Call prior to show • Purchaser may change the name of the individual retrieving tickets up to 48 hours in advance of event via the LivingSocial website event details section; no name-changes or alternate pick-ups permitted without notice at venue • Event is rain or shine • LivingSocial is pleased to offer you the opportunity to purchase this deal to be fulfilled by the entity indicated on the voucher and/or by Anschutz Entertainment Group, Inc., its subsidiaries and affiliates ("AEG"). By purchasing this deal, you agree that your name, email, zip code and other information related to the deal you purchased will be used by LivingSocial as well as provided by LivingSocial to AEG and/or the entity indicated on the voucher to assist in fulfilling the deal you purchased and, subject to LivingSocial's privacy policy [livingsocial.com/privacy_policy] as well
Other conditions apply
Except where noted in the fine print:
• Cannot be combined with any other offer or promotion
• Tax and gratuity are not included
• Merchant is responsible for the quality of the products or services provided to you at redemption
• LivingSocial Terms and Conditions - https://m.livingsocial.com/terms
Ticket Package to SP Style Anniversary Blowout
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Six Laser Hair Removal Treatments
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The Refuge Golf Club
18-Hole Round of Golf for 2 People
Kitchen Window
Cooking Class + $10 to Spend In-Store


text:
Sometimes the numbers add up in unexpected ways. The Yankees entered Friday night's game against Angels lefthander C.J. Wilson as the top-hitting team against lefties in the American League. But they managed only four hits in six innings against Wilson and the Angels pummeled Yankees starter Hiroki Kuroda for eight runs on their way to a 13-1 victory at Yankee Stadium.
Angels Batter Hiroki Kuroda in 13-1 Win over Yankees
From Newsday.com
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Andy Marlin/Getty Images


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