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Uterine cancer statistics
New cases of uterine cancer, 2013, UK
Deaths from uterine cancer, 2014, UK
Survive uterine cancer for 10 or more years, 2010-11, England and Wales
Preventable cases of uterine cancer, UK
- There were around 9,000 new cases of uterine cancer in the UK in 2013, that's 25 cases diagnosed every day.
- Uterine cancer is the 12th most common cancer in the UK (2013).
- Uterine cancer accounts for 3% of all new cases in the UK (2013).
- In females in the UK, uterine cancer is the fourth most common cancer, with around 9,000 cases diagnosed in 2013.
- Almost 6 in 10 (58%) uterine cancer cases in the UK each year are diagnosed in females aged 65 and over (2011-2013).
- Since the late 1970s, uterine cancer incidence rates in females have increased by around two-thirds (65%) in Great Britain.
- Over the last decade, uterine cancer incidence rates in females have increased by a quarter (25%) in the UK.
- Most uterine cancer cases are diagnosed at an early stage.
- Most uterine cancers occur in the endometrium.
- 1 in 41 women will be diagnosed with uterine cancer during their lifetime.
- Uterine cancer incidence in England is not associated with deprivation.
- Uterine cancer is as common in White, Asian and Black females.
- In the UK around 38,700 women were still alive at the end of 2006, up to ten years after being diagnosed with uterine cancer.
- In Europe, around 99,000 new cases of uterine cancer were estimated to have been diagnosed in 2012. The UK incidence rate is 20th highest in Europe.
- Worldwide, more than 319,000 women were estimated to have been diagnosed with uterine cancer in 2012, with incidence rates varying across the world.
- There were around 2,200 uterine cancer deaths in the UK in 2014, that's around 6 deaths every day.
- Uterine cancer is the 19th most common cause of cancer death in the UK (2014).
- Uterine cancer accounts for 3% of all cancer deaths in females in the UK (2014).
- In females in the UK, uterine cancer is the ninth most common cause of cancer death, with around 2,200 deaths in 2014.
- Around half (49%) of uterine cancer deaths in the UK each year are in females aged 75 and over (2012-2014).
- Mortality rates for uterine cancer in the UK are highest in females aged 85-89 (2012-2014).
- Since the early 1970s, uterine cancer mortality rates in females have decreased by less than a tenth (7%) in the UK.
- Over the last decade, uterine cancer mortality rates in females have increased by less than a fifth (16%) in the UK.
- Uterine cancer deaths in England are more common in males living in the most deprived areas.
- In Europe, around 99,000 new cases of uterine cancer were estimated to have been diagnosed in 2012. The UK incidence rate is 20th highest in Europe.
- Worldwide, more than 319,000 women were estimated to have been diagnosed with uterine cancer in 2012, with incidence rates varying across the world.
- Almost 7 in 10 (78%) women diagnosed with uterine cancer in England and Wales survive their disease for ten years or more (2010-11).
- Around 8 in 10 (79%) women diagnosed with uterine cancer in England and Wales survive their disease for five years or more (2010-11).
- 9 in 10 (90%) women diagnosed with uterine cancer in England and Wales survive their disease for one year or more (2010-11).
- Almost 9 in 10 women in England diagnosed with uterine cancer aged 15-39 survive their disease for five years or more, compared with less than 6 in 10 women diagnosed aged 80 and over (2009-2013).
- Uterine cancer survival is improving and has increased in the last 40 years in the UK.
- In the 1970s, almost 6 in 10 women diagnosed with uterine cancer survived their disease beyond ten years, now it's almost 8 in 10.
- When diagnosed at its earliest stage, 95% of women with uterine cancer will survive their disease for five years or more, compared with around 3 in 20 women when diagnosed at the latest stage.
- A person's risk of developing cancer depends on many factors, including age, genetics, and exposure to risk factors (including some potentially avoidable lifestyle factors).
- 37% of uterine cancer cases each year in the UK are linked to major lifestyle and other risk factors.
- Factors which reduce lifetime exposure to oestrogen may relate to lower uterine cancer risk.
- Overweight and obesity is the main potentially avoidable risk factor for uterine cancer, linked to an estimated 34% of uterine cancer cases in the UK.
- An estimated 37% of uterine cancer cases in the UK are linked to lifestyle factors including overweight and obesity, lack of physical activity (4%), and hormone replacement therapy (1%).
- Certain medical conditions and treatments may be linked with higher uterine cancer risk.
- Some types of oral contraceptives are linked with lower uterine cancer risk.
- 'Two-week wait' is the most common route to diagnosing uterine cancer.
- GP referral is the route with the highest proportion of cases diagnosed at an early stage, for uterine cancer.
- 'Two-week wait' standards are met by all countries, '31-day wait' is met by all but Northern Ireland and Wales, and '62-day wait' is met by all but Wales, Northern Ireland and only partly by Scotland for gynaecological cancers.
- Around 8 in 10 uterine cancer patients receive major surgical resection as part of their cancer treatment.
- 9 in 10 patients had a 'very good' or 'excellent' patient experience.
- 9 in 10 patients are given the name of their Clinical Nurse Specialist.
See more in-depth uterine cancer diagnosis and treatment statistics
The latest statistics available for uterine cancer in the UK are; incidence 2013, mortality 2014 and survival 2010-2011 (all ages combined) and 2009-2013 (by age).
Uterine cancer is sometimes called womb cancer, and is occasionally reported as body of the uterus (C54) alone.
European Age-Standardised Rates were calculated using the 1976 European Standard Population (ESP) unless otherwise stated as calculated with ESP2013. ASRs calculated with ESP2013 are not comparable with ASRs calculated with ESP1976.
Lifetime risk estimates were calculated using incidence, mortality, population and all-cause mortality data for 2012.
Survival statistics give an overall picture of survival and (unless otherwise stated) include all adults (15-99) diagnosed, at all ages,
Stage at diagnosis data is not yet routinely available for the UK due to inconsistencies in the collecting and recording of staging data in the past.
Most cases of uterine cancer are in the endometrium; accordingly most evidence cited on our risk factors page is for endometrial cancer specifically rather than uterine cancer overall. The specific cancer type is stated where possible.
Routes to diagnosis statistics were calculated from cases of cancer registered in England which were diagnosed in 2012-2013. Staging proportions only include patients with a known stage (cases with an unknown stage at diagnosis are not included in the denominator).
Cancer waiting times statistics are for patients who entered the health care system within financial year 2014-15. Uterine cancer is part of the group 'Gynaecological cancer' for cancer waiting times data. Codes vary per country but broadly include: Vulva, vagina, cervix, uterus, ovary, other female genital organs, placenta and secondary cancers of ovary.
Cancer surgical resection rates data is for patients diagnosed in England between 2006 and 2010.
Patient Experience data is for adult patients in England with a primary diagnosis of cancer, who were in active treatment between September and November 2013 and who completed a survey in 2014.
Deprivation gradient statistics were calculated using incidence data for three time periods: 1996-2000, 2001-2005 and 2006-2010 and for mortality for two time periods: 2002-2006 and 2007-2011. The 1997-2001 mortality data were only used for the all cancers combined group as this time period includes the change in coding from ICD-9 to ICD-10. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.
You are welcome to reuse this Cancer Research UK statistics content for your own work.
Credit us as authors by referencing Cancer Research UK as the primary source. Suggested styles are:
Web content: Cancer Research UK, full URL of the page, Accessed [month] [year].
Publications: Cancer Research UK ([year of publication]), Name of publication, Cancer Research UK.
for any other cancer statistics or information at: email@example.com
We would like to acknowledge the essential work of the cancer registries in the United Kingdom and Ireland Association of Cancer Registries, without which there would be no data.


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Humboldt kept its perfect record intact Thursday night, as the 21-0 Wildcats defeated the Clear Lake Lions 3-0. The Wildcats sit atop the North Central Conference standings with a 3-0 record. The Lions are now 1-3. Clear Lake gave Humboldt, eighth ranked in Class 3A, a solid test. The Wildcats captured the first game, 25-18,…Read more
GHV X-C boys win another title
It was another successful night for the Garner-Hayfield-Ventura cross country, with the boys team winning by a landslide and the girls placing ninth at the Humboldt Meet held on Monday, Sept. 20. The boys dominated the 20-team field with 54 points. Humboldt was second with 98, followed by Mason City with 100 and Fort Dodge…Read more
Mirror-Reporter E-edition 9-28-2016
Read about Clear Lake's minor flooding in this week's e-edition. Also - find your Harvest Festival schedule!Read more
Ada M. Hill
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Effect of Leptin on Neutrophils Phagocytosis and Lymphocytes Apoptosis Challenge by Listeria monocytogenes and Escherichia coli
Background: Leptin is a cytokine/hormone produced mainly by the adipocytes which regulates the body weight. The normal level of Leptin is required for optimal immune system function, and high leptin levels are shown to affect the Th1-Th2 balance. Leptin is able to stimulate monocytes, dendritic cells and Neutrophils.
Objectives: The aim of this study was to evaluate the effect of leptin on neutrophils phagocytosis and lymphocytes apoptosis stimulated by Listeria monocytogenes and Escherichia coli.
Materials and methods: Blood samples were taken from healthy volunteers and were treated with either leptin or PBS in presence or absence of L. monocytogenes or E. coli. In order to evaluate the activation of neutrophils and their phagocytosis activity, the expression of CD11b by these cells were assessed using flow cytometry. The ability of leptin to induce apoptosis in lymphocytes was investigated using Annexin V and PI staining method by flow cytometry.
Results: Our data demonstrates that leptin is able to induce CD11b expression on neutrophils but this induction is significantly less than L. monocytogenes. Indeed, cells treated with leptin had lower amounts of apoptosis compared with untreated cells. The highest amount of apoptosis was seen in cells treated with L. monocytogenes vs. E. coli. Leptin can be used as a potent agent for induction of effective bacterial phagocytosis and lymphocytic apoptosis in cases with sever immune-deficiency.
Conclusions: The Leptin can also be used for the treatment of severe and intractable L. monocytogenes and E. coli infection.
Keywords: Leptin; Neutrophil; Lymphocyte; Apoptosis; Phagocytosis; Listeria monocytogenes; Escherichia coli
1. Background
Leptin, an adipose-derived hormone/cytokine, is a powerful defending element of Immune system against bacterial infections (1, 2). Congenital leptin deficiency causes immune dysfunction in affected newborns and is associated with early childhood death due to overwhelming infections (2, 3). Administration of leptin to leptin deficient mice has been shown to make them resistant to Klebsiella pneumonia (4). Leptin stimulates the proliferation of peripheral monocytes in-vitro and leads to enhanced expression of CD11b, a marker of neutrophilic phagocytosis, on the surface of monocytes (5, 6). Despite the potent role of leptin in immune system functions, its interaction with diverse pathogenic bacteria, especially intracellular bacteria which potentially escape from phagocytosis by immune cells, is not well understood.
Listeria monocytogenes is an intracellular pathogen which causes various diseases such as fulminant Listeriosis, meningitis, endocarditis and disseminated bacteremia mainly in immune-deficient patients and neonates (2, 7,8). Listeriolysin secreted by L. monocytogenes, inhibits the procedure of macrophage-mediated processing of bacterial antigens (9, 10). Indeed, L. monocytogenes destructs cell membranes especially phagosomemembranes thatleads to intracellular bacterial growth (9, 10). L. monocytogenes potently induces apoptosis in T-cell lymphocytes through both caspase-dependent and independent pathways (11, 12). After phagocytosis of L. monocytogenes by antigen-presenting cells (APC), the produced Listeriolysin O potentiates its cytosolic growth which leads to APC death through inflammatory mediators (13, 14). Due to the diverse effects of this pathogen on induction of apoptosis and phagocytosis of immune cells and its ability to escape from immune system, L. monocytogenes was selected to be used in this study (8).
2. Objectives
The aim of this study was to investigate the role of leptin in induction of phagocytosis and apoptosis on cells of immune systems infected by L. monocytogenes. Since Escherichia coli has been shown to enhance the CD11b expression on the surface of neutrophils triggered by the presence of FMLP, E. coli was used as a control bacteria in this study (15).
3. Materials and Methods
10-15 mL of heparinized blood were drawn from healthy male volunteers (age 21-34) after they have signed informed contest form. The study was approved by local ethics committee. To evaluate the blood neutrophils, 100 µL of blood was transferred into each sterile flow cytometry tube. Samples were treated differently as listed in Table 1. L. monocytogenes PTCC1295 and non-pathogenic E. coli were grown in TSA/TSB (Merck, Germany) culture medium supplemented with 1% yeast extract (Merck, Germany) and 10% human blood and Nutrient agar (Merck, Germany )culture medium, respectively. L. monocytogenes
was used for stimulation of PBMCs (Peripheral Blood Mononuclear cells) compared with E. coli as a control. For bacterial challenge, 108 bacteria were added to 10 6 cell (multiplicity of infection=100).
Leptin (R&D systems, USA) was used at a concentration of 250ng/mL. After treatments, tubes were incubated in thermomixer for 10 min at 37°C and incubation was carried out for 3 hours. Cells were incubated with 5 µL of listed antibodies for 20 min at 40°C in dark. Then, RBCs were lysed using RBC lysis buffer (DAKO 53350, Germany). The neutrophilsCD11b expression, as anactivity and phagocytosismarker, was evaluated using flow cytometry (Partec PAS, Germany) after staining with FITC-conjugated murine anti-human CD11b monoclonal antibody (Serotec, England). FITC-conjugated murine IgG1 monoclonal antibodies (Serotec, England) were used as staining control antibody. Data were analyzed using Flow Max software (Partec, Germany). All experiments were repeated 15 timesFor assessment of apoptosis, 10 mL of blood was used for isolation of mononuclear cells (PBMCs) from peripheral blood using Histopaque (Sigma A6929, Germany) centrifuged at 400g for 30 min according to manufacturer's recommendations.
After gentle mixing of isolated peripheral blood mononuclear cells with phosphate buffer saline (PBS, CMG Iran), cells were centrifugated at 250g for 10 min. Then, cells were transferred into RPMI-1640 culture media (Sigma R8755, Germany) and were washed twice. Isolated PBMCs were counted using improved Neobarhaemocytometer. To confirm and assess the presence of T-lymphocyte, cells were labeled with anti-human CD3-antibody (BD Pharmingen, USA) and were counted by flow cytometry.
Table 1.
Different Treatments of Blood Samples for Assessment of Cd11b Expression
After treatment of cells according to Table 2, cells were incubated in thermomixer for 10 min at 37°C. Allowing the inoculated bacteria to exert their effects on cells, cells were incubated for 24 h at 37°C. Doxorubicin, Germany (50 mg/25 mL) was used as a positive control for induction of cell apoptosis. All experiments were repeated 12 times. For analysis of apoptosis, cells were incubated with FITC-conjugated Annexin V (BD Pharmingen, USA) and PI (BD Pharmingen, USA) for 30 min at 40°C and were analyzed by flow cytometry (Partec PAS, Germany), data were analyzed using Flow Max software. For statistical analysis, t-test via SPSS v.17 was used. The list of treatments for apoptosis is demonstrated in Table 2.
Table 2.
Different Treatments of Blood Samples for Assessment of Apoptosis
4. Results
CD11b expression on the surface of peripheral blood neutrophils indicates the occurrence of phagocytosis leading to neutrophil stimulation. Data in Figure 1 show the expression of CD11b after various treatments.After 24 h, 0.27%, 8.87% and 90.80% of non-treatedlymphocytes were apoptotic, necrotic and viable, respectively (Figure 2). In Doxorubicin treated cells (as a control), after 24 h, 43.04% and 53.60 of cells were apoptotic and viable, respectively. Doxorubicin potently induced apoptosis in treated cells. The percentage of apoptotic cells treated with leptin, E. coli and L. monocytogenes were 2.62%, 4.43% and 7.94%, respectively, after 24 h. L. monocytogenes induced apoptosis more potent than leptin and E. coli(P<0.05). Cell treated with leptin and L. monocytogenes after 24 h showed less apoptosis rate (4%) than only L. monocytogenes treated cells (P < 0.05). Table 3 demonstrates the rate of apoptosis induction on lymphocytes after various treatments. Data in Figure 3 indicates the rate of apoptosis in neutrophils treated with L. monocytogenes , E.coli , leptin+ L. monocytogenes and leptin+ E. coli and E. coli , E. coli + Leptin, L. monocytogenes and L. monocytogenes + leptin. Figures 3 and 4 illustrate the percentage of apoptosis, necrosis, apoptosis and necrosis and viability of cells treated with L. monocytogenes , E. coli , leptin + L. monocytogenes , leptin + E. coli and E. coli , leptin+ L. monocytogenes and L. monocytogenes.
4.1. Effects of Leptinon CD11b Expression
4.2. Effects of Leptin on Induction of Apoptosis
CD11b expression on the surface of peripheral blood neutrophils indicates the occurrence of phagocytosis leading to neutrophil stimulation. Data in Figure 1 show the expression of CD11b after various treatments.After 24 h, 0.27%, 8.87% and 90.80% of non-treatedlymphocytes were apoptotic, necrotic and viable, respectively (Figure 2).
In Doxorubicin treated cells (as a control), after 24 h, 43.04% and 53.60 of cells were apoptotic and viable, respectively. Doxorubicin potently induced apoptosis in treated cells. The percentage of apoptotic cells treated with leptin, E. coli and L. monocytogenes were 2.62%, 4.43% and 7.94%, respectively, after 24 h. L. monocytogenes induced apoptosis more potent than leptin and E. coli(P<0.05). Cell treated with leptin and L. monocytogenes after 24 h showed less apoptosis rate (4%) than only L. monocytogenes treated cells (P < 0.05).
Table 3 demonstrates the rate of apoptosis induction on lymphocytes after various treatments. Data in Figure 3 indicates the rate of apoptosis in neutrophils treated with L. monocytogenes , E.coli , leptin+ L. monocytogenes and leptin+ E. coli and E. coli , E. coli + Leptin, L. monocytogenes and L. monocytogenes + leptin. Figures 3 and 4 illustrate the percentage of apoptosis, necrosis, apoptosis and necrosis and viability of cells treated with L. monocytogenes , E. coli , leptin + L. monocytogenes , leptin + E. coli and E. coli , leptin+ L. monocytogenes and L. monocytogenes.
5. Discussion
The major finding of this investigation is that L. monocytogenes enhances the neutrophilic phagocytosis more than E. coli. L. monocytogenes is an intracellular pathogen which is able to escape from immune systemand phagosomes through secretion of Listeriolysin. The principal cause of enhanced CD11b expression is the neutrophil stimulation by this toxin. The mechanism of apoptosis by Listeriolysin has been demonstrated to be mediated by CR3-receptor (CD11b and CD18) which play the principal role in bacterial eradication (15, 16). The potent stimulation of phagocytosis by L. monocytogenes compared with E. coli, based on our data, is due to its ability to stimulate CD11b expression more effectively than E. coli. Regarding bacterial phagocytosis, our data demonstrates enhanced neutrophilic phagocytosis and CD11b expression on the surface of neutrophils stimulated by L. monocytogenes and E. coli.
Leptin involves in modulation of neutrophilic phagocytosis after binding to Ob-R receptor expressed on the surface of neutrophils (5). Leptin stimulates neutrophils and enhances accumulation of reactive oxygen within neutrophilicphagosomes (5, 17). In this way, leptin enhancesneutrophilic phagocytosis (18, 19). Leptin actively participates in formation of phagosomes through stimulation of actin polymerization and modulation of actinomyosine interaction (20). Knock-out mice for leptin hormone, showed defective phagocytosis responses to Klebsiella pneumonia. Neutrophils in complement-rich and leptin-deficient environment showed a decreased expression of CD11b which became normalized by leptin treatment (4).
Leptin role in induction of phagocytosis is CD11b-dependent. Leptin deficiency is associated with enhanced susceptibility to bacterial infection (21). Zarkesh-Esfahani et al. have demonstrated that leptin, by itself, was not able to stimulate CD11b expression on the surface of neutrophils,while addition of monocytes to neutrophils enhanced CD11b expression in the presence of leptin through stimulation of neutrophils by secreted TNF-α (6). Then, leptin can be used to enhance neutrophilic phagocytosis in bacterial infections such as L. monocytogenes. Leptin enhanced phagocytosis of L. monocytogenes more potent than E. coli.
Induction of apoptosis in murine lymphocytes by L. monocytogenes has been demonstrated by Carro et al. in which Listeriolysin O, as a virulent factor, has been considered todirectly induce apoptosis at very low concentrations (22). Injection of L. monocytogenes into mouth, caused wound creation in lymphatic tissue and aggregation of macrophages and neutrophils accompanied by dramatic decrease in the number of T lymphocytes (23). The data demonstrate that L. monocytogenes induced apoptosis more potent than E. coli, which is compatible with previous reports. This might be due to the presence of apoptotic factor Listeriolysin O, which is absent in E. coli. In control lymphocytes only treated with leptin, attenuated lymphocytic apoptosis was observed. Leptin has been shown to decrease lymphocyte apoptosis rate through inhibition of FAS-directed apoptosis pathway (24).
B-cell lymphocytes are more susceptible to induce the apoptosis by leptin related to greater expression of leptin receptor on their surface compared with T-cell lymphocytes (24). Continuous leptin injection into the starved mice has been associated with decreased lymphocyte loss through inhibition of cell apoptosis (25). Leptin injection into mice with enhanced lymphocyte apoptosis as a consequence to steroid administration, has reversed the process (25). Induced lymphocytic apoptosis by leptin is implicated in potentiating immune defense against virulent pathogens. Our data regarding the effects of leptin on induction of apoptosis is compatible with previous findings. Interestingly, our data demonstrates accentuated apoptosis induction after treatment of L. monocytogenes activated lymphocytes by leptin.
Leptin can be used as a potent agent for an effective induction of bacterial phagocytosis and lymphocytic apoptosis in the cases with sever immune-deficiency. It can also be used for the treatment of severe and intractable L. monocytogenes and E. coli infections.
None declared.
- 1. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004;4(5):371-9. [DOI] [PubMed]
- 2. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, et al. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005;90(3):1625-31. [DOI] [PubMed]
- 3. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110(8):1093-103. [DOI] [PubMed]
- 4. Moore SI, Huffnagle GB, Chen GH, White ES, Mancuso P. Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun. 2003;71(7):4182-5. [PubMed]
- 5. Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C, et al. Role of leptin in the activation of immune cells. Mediators Inflamm. 2010;2010:568343. [DOI] [PubMed]
- 6. Tian Z, Sun R, Wei H, Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002;298(3):297-302. [PubMed]
- 7. Economou M, Karyda S, Kansouzidou A, Kavaliotis J. Listeria meningitis in children: report of two cases. Infection. 2000;28(2):121-3. [PubMed]
- 8. Portnoy DA, Auerbuch V, Glomski IJ. The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol. 2002;158(3):409-14. [DOI] [PubMed]
- 9. Birmingham CL, Canadien V, Kaniuk NA, Steinberg BE, Higgins DE, Brumell JH. Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles. Nature. 2008;451(7176):350-4. [DOI] [PubMed]
- 10. Carrero JA, Calderon B, Unanue ER. Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule. J Immunol. 2004;172(8):4866-74. [PubMed]
- 11. Zychlinsky A, Sansonetti P. Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis. J Clin Invest. 1997;100(3):493-5. [DOI] [PubMed]
- 12. Leib SL, Kim YS, Chow LL, Sheldon RA, Tauber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest. 1996;98(11):2632-9. [DOI] [PubMed]
- 13. Savill J. Phagocyte recognition of apoptotic cells. Biochem Soc Trans. 1996;24(4):1065-9. [PubMed]
- 14. Carrero JA, Unanue ER. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends Immunol. 2006;27(11):497-503. [DOI] [PubMed]
- 15. Gordon DL, Rice JL, McDonald PJ. Regulation of human neutrophil type 3 complement receptor (iC3b receptor) expression during phagocytosis of Staphylococcus aureus and Escherichia coli. Immunology. 1989;67(4):460-5. [PubMed]
- 16. Abbas KA, Lichtman AH, Pober JS. Cellular and Molecular Immunology. W.B. Saunders Company; 1997 . ISBN 13: 978-0721600086.
- 17. Caldefie-Chezet F, Poulin A, Tridon A, Sion B, Vasson MP. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J Leukoc Biol. 2001;69(3):414-8. [PubMed]
- 18. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol. 2002;168(8):4018-24. [PubMed]
- 19. Shirshev SV, Orlova EG. Molecular mechanisms of regulation of functional activity of mononuclear phagocytes by leptin. Biochemistry (Mosc). 2005;70(8):841-7. [PubMed]
- 20. Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M, et al. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J. 2000;14(14):2329-38. [DOI] [PubMed]
- 21. Zarkesh-Esfahani H, Pockley AG, Wu Z, Hellewell PG, Weetman AP, Ross RJ. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol. 2004;172(3):1809-14. [PubMed]
- 22. Tian Z, Sun R, Wei H, Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002;298(3):297-302. [PubMed]
- 23. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394(6696):897-901. [DOI] [PubMed]
- 24. Merrick JC, Edelson BT, Bhardwaj V, Swanson PE, Unanue ER. Lymphocyte apoptosis during early phase of Listeria infection in mice. Am J Pathol. 1997;151(3):785-92. [PubMed]
- 25. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176(12):7745-52. [PubMed]
- 26. Fujita Y, Murakami M, Ogawa Y, Masuzaki H, Tanaka M, Ozaki S, et al. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol. 2002;128(1):21-6. [PubMed]


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In a single Huffington Post column, NASA's famous warmist-alarmist Dr. James Hansen invokes Godwin's Law on climate change, criticizes President Obama for his lack of stalwart leadership in that area, and offers a climate change solution that would also discourage illegal immigration.
Obama's Second Chance on the Predominant Moral Issue of This Century
The predominant moral issue of the 21st century, almost surely, will be climate change, comparable to Nazism faced by Churchill in the 20th century and slavery faced by Lincoln in the 19th century. Our fossil fuel addiction, if unabated, threatens our children and grandchildren, and most species on the planet.
So the Cadillac Escalade enjoys the same moral standing as West African slave ships and Bergen-Belsen's crematoria. Got it.
Yet the president, addressing climate in the State of the Union, was at his good-guy worst, leading with "I know that there are those who disagree..." with the scientific evidence. This weak entrée, almost legitimizing denialists, was predictably greeted by cheers and hoots from well-oiled coal-fired Congressmen. The president was embarrassed and his supporters cringed....
Why face the difficult truth presented by the climate science? Why not use the president's tack: just talk about the need for clean energy and energy independence? Because that approach leads to wrong policies, ineffectual legislation larded with giveaways to special interests, such as the Waxman-Markey bill in the House and the bills being considered now in the Senate.
What prescription is offered our President? Hansen has only one: We must tax the bejeezus out of carbon-based energy consumption.
An essential corollary to the rising carbon price is 100 percent redistribution of collected fees to the public -- otherwise the public will never allow the fee to be high enough to affect lifestyles and energy choices. The fee must be collected from fossil fuel companies across-the-board at the mine, wellhead, or port of entry. Revenues should be divided equally among all legal adult residents, with half-shares for children up to two per family, distributed monthly as a "green check". ...
The fee-and-green-check approach is transparent, fair and effective. ... Economic modeling shows that carbon emissions would decline 30 percent by 2020. The annual dividend would be $2000-3000 per legal adult resident, $6000-9000 per family with two or more children.
About sixty percent of the public would receive more in the green check than they pay in added energy costs. ...
[Emphasis added.]
Oh, and the cost to administer such a program? Dr. Hansen doesn't say, so I guess it's fair to assume it will be negligible...
Let's look at the numbers of this proposal. Something like 4% of the population is, um, suboptimally documented. About 28% of women have more than two children. Allowing for some overlap, that leaves 10-15% of us energy hogs (you, me, and Al Gore) to pay the freight so that 60% can get their "green check".
But notice that Hansen mentions twice that you have to be "legal" to be a green check recipient. So an family of illegals will have a heavy monetary incentive to go home. Was this Hansen's intended result? It's certainly not liberal dogma; surely we'll have to grant blanket amnesty before imposing this solution.
Perhaps most grating of all is Dr. Hansen's invoking of the name of Galileo:
This is not the 17th century, when "beliefs" trumped science, forcing Galileo to recant his understanding of the solar system. The president should unequivocally support the climate science community, which is under politically orchestrated assault on the legitimacy of its scientific assessments.
On the contrary, the Climategate memos paint a picture of a community of scientists who were more driven by "beliefs" than by a quest for the truth. The skeptics have confronted the putative "consensus" of the climate change political/scientific establishment just as Galileo was at odds with the political/scientific establishment of his day. It is Hansen and other representatives of the establishment who would have the skeptic community recant.
Cross-posted at VladEnBlog.


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Luau Hale restaurant in Lenox, MA is the longest established Asian cuisine restaurant in the Berkshires and also offers a large vegetarian menu.Luau Hale Restaurant features: daily lunch specials, family atmosphere, Chinese cuisine, Polynesian cuisine, Szechuan cuisine, American cuisine, and a vegetarian menu.
Since opening in 2003, On a Roll Cafe & Catering Co. Inc. has expanded into two great locations: 75 North Street, Pittsfield, MA, 01201 In the Central Block Tel: (413) 236 - 5671 55 Pittsfield Road, Lenox, MA, 01240 In the Lenox Commons Tel: (413) 637- 9544 Along with the convenience of being located next to the Beacon Cinema in Pittsfield the new location is conveniently located just off route 7 in the Lenox Commons, a favorite destination spot of tourists and local residents alike. On a Roll Cafe & Catering Co. also has an extensive catering menu. From a small intimate get-together to the large event, we can cater it like no other. Our menu includes a unique selection of ideas, but other items are available upon request. Whatever the occasion, On a Roll Cafe & Catering Co. Inc. is the place to be. If you have any questions about menus, functions or events, please call or drop us an e-mail!!
Papa John'sPizza|
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Wonderful nice owners set a friendly tone at this fine addition to Lenox, where terrific Mediterranean eats are matched by a great selection of reasonably priced wines...- Zagat Rated 2009
Betty's Pizza ShackPizza|Italian|Deli/Sandwiches|American|
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Pizza, appetizers, wings, sandwiches, burritos, quesadilla's. Take out and dine in.
Since opening in 1999 Bistro Zinc has been a favorite gathering spot for locals and visitors alike. Bistro Zinc is open 7 days a week for lunch and dinner and the bar doesn't shut down til 1am.
Featuring regional Italian preparations, local organic produce, natural & organic meats, excellent wines, full bar, intimate dining in former 1840's farmhouse, A/C, alfresco dining on covered Mahogany deck, private parties. Chef owned & operated since 1983. Take out available. Reservations appreciated.
Chocolate Springs CafeBakery|
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"Chocolate Springs Café specializes in handcrafted European-style gourmet dark chocolates, milk chocolates, chocolate truffles, chocolate infusions, chocolate mousse cakes, cheesecakes, cookies and pastries as well as our own ice cream and sorbets. The full espresso bar, assorted teas and serious hot chocolate have become local favorites. Joshua Needleman, creator and chocolatier, has loved chocolate all of his life. His fascination with this magical ingredient, inherited from his Dutch grandmother and family, has evolved into an art form. His goal is to create a balanced harmony between the natural complexities of the natural dark chocolate and his flavor infusions."
The cafe has always featured the best work of local artists and our guests describe the cafe as having "great art to eat by."
Electra's CafeMediterranean|Greek|Deli/Sandwiches|Breakfast/Bagels|American|
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Electra's Cafe is a small business started on August 10, 2012 with 38 seats. We do not do pre-made fast food. Each order is made fresh with quality ingredients and therefore requires a little time to ensure we give you a great meal.
"Eat.Drink.Laugh" "Creative American cuisine"
Ciao! Welcome to Frankie's Ristorante Italiano. We are located in downtown Lenox, Mass. Here you can find the kind of real, home-made Italian food that you've been looking for. Please stop by. We're open for dinner every day. Arrivederci!
Haven Cafe & BakeryPizza|Breakfast/Bagels|Bakery|
Open Right Now!
"The priority at Haven is food and community."
Dining at the Gateways offers a menu of Creative and Contemporary American dishes, showcasing the talents of our Chef and staff. The philosophy of the Culinary Team at the Gateways Inn & Restaurant is to utilize the finest and freshest products available. Our seasonal menus reflect this goal. In this pursuit, we are strong supporters of Berkshire Grown, our agricultural organization bringing together farmers and chefs to promote the use of locally grown food.
Mazcots Sports Bar and GrillPub|
Open Right Now!
Sports Bar and Grill, 20 Beers on Tap, Great food open for lunch ! Keno, pool tables, games for the kids and plenty of room for friends and family!!
Olde Heritage TavernPub|Breakfast/Bagels|American|
Open Right Now!
This is the place that the "Lenox Locals" come to meet friends, eat, or just sit back and relax to watch a game. The "Heritage," as it is know in town, serves great food and drinks at non-Lenox prices. There are always specials, but since everything is home-made, anything you order will satisfy you.
Chinese food take-out and dine in.
Prime Italian Steakhouse and Bar serves a variety of steak, seafood, and italian favorites. There is a full bar.
seasonally-changing dinner menu is supplemented with daily specials that take advantage of the freshest available ingredients. Colonial-inspired dishes, such as Shaker-Style Cranberry Pot Roast and Roasted Duck mix with perennial gourmet favorites, such as Filet Mignon and Fresh Salmon. Rumplestiltzkin's offers a full bar and extensive wine list including "by-the-glass" selections. After dinner, stop by Rumpy's for a nightcap.
Shots CafeDeli/Sandwiches|Breakfast/Bagels|
Open Right Now!
Cafe, deli, Sandwiches
Dining at the Gateways offers a menu of creative and Contemporary American dishes, showcasing the talents of our Chef and staff. The philosophy of the Culinary Team at the Gateways Inn Restaurant is to utilize the finest and freshest products available. Our seasonal menus reflect this goal. In this pursuit, we are strong supporters of Berkshire Grown, our agricultural organization bringing together farmers and chefs to promote the use of locally grown food.
New breakfast & lunch spot in The Lenox Commons! Breakfast every day from 7 a.m. to 3 p.m.
Located in the beautiful Berkshire Hills of Western Massachusetts, just north of Lenox Center, and just South of Pittsfield, Trattoria Il Vesuvio serves the finest in authentic Italian cuisine. We feature traditional Italian dishes as well as freshly prepared selections from our wood fired-brick oven. Beer, wine, and mixed drinks are also available with both lunch and dinner. Our restaurant is converted from a turn of the century wooden stable. We offer a casual dining atmosphere suitable for the special evening for two, or an excellent home cooked meal for the whole family.
The innovative cuisine of Chef Jeffrey Thompson is infused with a subtle intensity and passion that is an ideal complement to the elegance and sophistication of Wheatleigh dining. His exquisite presentations, accompanied by the finest wines, are served flawlessly by our European trained staff. From the first glass of champagne to the last espresso, there is nothing more important than the pleasure of our guests, and there is no more extraordinary way to spend an evening.
DISCLAIMER: Information shown may not reflect recent changes. Please check with each restaurant for current hours, pricing, and menu information. To submit updated information for a listing please contact firstname.lastname@example.com


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Sep 12 2015
Kin W. via Yelp
Thank you so much for the delivery. A+ service. The lady was patience on the phone. The pizza taste very good. I told her that I am a trucker, and they...read more
Sep 05 2016
Michael G. via Yelp
Service what service? You could half starve to death waiting for the one and only waitress. Drinks never get refilled (I actually had to take my cup to...read more
Dec 31 2015
Matt C. via Yelp
Stopped there last night and there were several problems. First off I call ahead and get told when I get there it will be 35 minutes I explained to them I...read more
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Live Q&A, Thursday 5 June: technology's potential may be undeniable but could it start an education revolution?
The director of investments at Omidyar Network Africa discusses the impact of the internet on citizen journalism and activism. Interviewed by Adam Davidi and Michael Berliner
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We're celebrating the 50-year anniversary of the 1966 FIFA World Cup™ with a Facebook contest!
Brazil, Uruguay and Argentina came out on top in the South American qualifier, securing spots at the FIFA Beach Soccer World Cup Dubai 2009.


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To follow up on this week's announcement of FINAL FANTASY XIII-2, here is a teaser trailer to whet your appetite further. Enjoy! Please look out for more information as soon as we can share it with you.
Plus members save up to 50% on Final Fantasy XIV, Abzu, Song of the Deep and more. Offers end 10/4.
We at Square Enix are delighted to let you know that the sequel to FINAL FANTASY XIII, FINAL FANTASY XIII-2, is coming next winter. We have a new story in store that stems from the previous title, a battle system that is evolved from "XIII" – and more… We're looking forward to sharing more details […]
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Top 20 things that make women suspiciousANI | Jun 13, 2013, 12.00 AM IST
Men who are "too nice" to their other half spark fears that they are cheating, a new study has found.
Researchers of the study that two thirds of women become suspicious if their partner suddenly has "new tricks" in the bedroom, makes grand romantic gestures or even if he makes them breakfast in bed.
Other triggers for suspicion amongst mistrusting wives and girlfriends are if their man treats them to jewellery or sexy underwear.
According to the poll of 2,000 adults conducted by Kellogg's, even helping out with housework leads to millions of females to believe her chap is "playing away".
A third of women said they would be happy to turn a blind eye to a minor indiscretion if it meant that their partner was nicer to live with.
"It seems there is an emotional gulf between the sexes when it comes to matters of the heart," the Daily Mail quoted Louise Thompson Davies, a spokesman from Kellogg's as saying.
"So when men think they are just being nice and showering their other half with gifts and affection they think they are being attentive but the reality is that women just don't see it like that.
"Today's work and life pressures have resulted in romantic gestures like making your wife or girlfriend breakfast in bed much more of a rare occasion.
"This is why most women tend to reach for the panic button and suspect the worst when they are made a fuss over.
"The smallest changes in a man's behaviour can set a women's mind whirring and get them worrying.
"But it's interesting to see how many women would be willing to ignore their suspicions and just enjoy having a new more attentive partner.
"It seems that for some women having a romantic and thoughtful partner is more important than having one that is faithful," Davies said.
The study also found that surprise gifts of chocolates would instantly cause concern for most women, with one in six women saying that their partner has given them a gift in the past because of a guilty conscience.
The top 20 things that make women suspicious are:
- Buys jewellery
- New moves in the bedroom
- More emotional
- Buys flowers
- Buys chocolates
- More attentive
- Buys sexy underwear
- Book a romantic weekend away
- Buys you more things
- Helps more with the chores
- Tells you he loves you more
- Makes breakfast in bed
- Pays more compliments
- Texts more
- Does the cooking
- Calls more
- Listens better
- Runs baths
- Hand over the TV remote
- Cuddles more
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Legal Secretary Job Description
Primary responsibilities
- Support attorneys in a legal setting.
- Prepare correspondence and legal papers such as summonses, complaints, motions, responses, and subpoenas under the supervision of an attorney or a paralegal.
- Review legal journals and assist with legal research.
- Teach how to prepare documents for submission to the courts. .
- Perform transcription and dictation.
- Schedule meetings and arrange conference rooms.
- Alert manager about cancelations or new meetings.
- Manage travel and schedule.
- Handle information requests.
- Prepare correspondence and stuff mail into envelopes.
- Arrange for outgoing mail and packages to be picked up.
- Prepare statistical reports.
- Manage spreadsheets.
- Greet and receive visitor.
- Prepare confidential and sensitive documents.
- Coordinates office management activities.
- Determine matters of top priority and handle accordingly.
- Prepare agenda for meetings.
- Takes and transcribes dictation.
- Helps prepare office budget.
- Plans events and volunteer activities.
- Maintain office procedures.
- Coordinate travel arrangements; prepares itineraries; prepare, compile and maintain travel vouchers and records.
- Operate office equipment, such as photocopy machine and scanner.
- Coordinate committees and task forces.
- Relay directives, instructions and assignment to executives.
- Receive and relay telephone messages.
- Direct the general public to the appropriate staff member.
- Maintain hard copy and electronic filing system.
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Jul. 09, 2016 AppleOne Columbia, SC
Well-known and well-respected law firm in Downtown Columbia seeking a dynamic Legal Secretary to support multiple attorneys. The Legal Secretary is an integral piece in the overall...
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Sep. 15, 2016 ACT-1 Bakersfield, CA
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Welcome to Marylhurst University
A premier, not-for-profit, applied liberal arts and business university – Marylhurst offers bachelor's degree completion programs, master's degrees, courses, continuing education and impressive arts, music and cultural events. Discover what this small, private NW university called Marylhurst can do for you.
Learn more about Marylhurst's admissions requirements, application process and connect with an admissions counselor.
Marylhurst's online resources for current students, like class registration, student accounts , advising and career services and My Marylhurst.
Upcoming events, networks and career services, how to stay connected with Marylhurst, and how to access your transcripts and school records.
Impact the lives of our students–be a donor and give toward scholarship opportunities and other ventures that directly impact the Marylhurst community.
Welcome to 2016-17
How to Apply
Why Choose Marylhurst University
Regionally Accredited
Marylhurst is regionally accredited by the Northwest Commission on Colleges and Universities (NWCCU), and that means our institution is reviewed on a regular basis for quality and excellence.
Liberal Arts + Business
We are a leader in combining career-focused course content with highly sought-after applied liberal arts skills – like problem-solving, communication and ethics. This combination is woven into every single course by our faculty at Marylhurst. We don't just want you to be an exceptional graduate. We want you to be an exceptional, employed graduate.
Supporting Campus
Whether you study online or on our beautiful campus, we offer you small classes with individual focus from our renowned faculty. Plus, exceptional student services, like academic advising, career services, organizations, benefits and a close-knit network of students and alums.
View a map of our campus, including building locations, photos and videos.
"For more than 122 years, Marylhurst University has been dedicated to providing the northwest region academic excellence in a supportive, educational environment focused on student success. As Marylhurst's president, I am honored to continue the legacy and heritage of this incredible place. If you are considering Marylhurst as your academic home, I want to personally welcome you to our beautiful campus and look forward to partnering with you to achieve your educational goals." ~ Dr. Melody Rose, President
Marylhurst always has a lot going on like faculty presenting on interesting topics, students doing great things in our community or our music ensembles winning awards. Check out our news and features about Marylhurst University's students, faculty and extended community. Visit our full News section.
Vieda Baker '16, Master of Divinity, volunteers at Veterans Hospital, offering communion and other blessings to those in need. [Read More… ]
Marylhurst is a community hub of cultural, literary, art and music events offered on our campus – like our Summer on the Green outdoor concerts or our annual Reading Series. View all upcoming events at Marylhurst, and add our next concert, art show, reading lecture or opera to your calendar.
OCT. 1 – 31 | Cafe Characters by Cat Wilson
Marylhurst alum Cat Wilson '01 will show her Cafe Characters in Shoen Library's Streff Gallery.
OCT. 7 | Thibaut Garcia in Concert | 8 p.m.
Thibaut Garcia has already won several international competition prizes including first prize at the Guitar Foundation of America in Oklahoma City in 2015. Part of the Portland Classic Guitar Series.
Not a Marylhurst student? Let's get you started.


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Home > Sunglasses > Karl Lagerfeld > KL241S (505)
Size and availability
Free outbound and return shipping
30-day money-back guarantee
Low prices
Free outbound and return shipping
30-day money-back guarantee
Low prices
KL241S/505 Ophthalmic Glasses
These sunglasses are the perfect accessory on the beach, on the way to the office or in the city. There is only one slight drawback: all the envious looks you will attract. The KL241S is brand new on the market in 2016, with this eyewear you are at the cutting-edge of trends. Would another colour not be a better match for your favourite outfit? Check also the other styles of KL241Sin our 2015, and 2016 Karl Lagerfeld range.
The unisex Karl Lagerfeld model makes no distinction between men and women. Wearing full rim eyewear, you make it unmistakably clear that you are going the whole hog. The oval shape suits almost any type and is a particularly good choice for those who prefer unobtrusive eyeglasses. This oval frame is particularly suitable for heart-shaped faces, but also suits every other face shape, because the KL241S is a real all-rounder. The noble metal frame allows for filigree lines and creates an extraordinary lightness in appearance. In addition, metal eyeglasses are virtually indestructible - strong, flexible and corrosion resistant. Black is one of the undisputed classics. It can be combined with any outfit and simultaneously radiates elegance and naturalness. This brand of sunglasses, of course, also provides your eyes with optimum UV400 protection.
The model has already been ordered and will shortly be back in stock. If you order now, you will get the reduced price and once the goods arrive, we will send you your new Karl Lagerfeld on the same day. In our online shop we have consistently low prices. You won't get KL241S at such a low price, not even in the sale.
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Don't hesitate to call us at
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Gone Viral - Page 11
Some Foods We Eat Have Strange Origins [VIDEO]
I knew a lot of these, but the one that really got me was the cashews. Pretty much my favorite nut, and when you see how they grow, you will understand why they cost more than peanuts...
A Dad's Reply Sung to the Tune of Magic! "Rude" [VIDEO]
Everybody has their own way of parenting. What do you think of how this dad responded to his daughters boyfriend in song?
Lake Trip Gone Wrong – Manly Monday [VIDEO]
I could go into a long discussion of tow packages and proper tires for towing a boat out of the water, but I won't bore you with that. Lets see this guy try to use two trucks to get his pontoon boat out of the water, and fail.
A Kid That Doesn't Want A Disney Trip [VIDEO]
My son is 10 years old. He does not want to go to Disney. He has issue with 'mascot' full cover costumes. I think it might have started with a station mascot years ago. This little boy doesn't want to go either!
Ride A Bike With A Skirt, Without Flashing Everyone [VIDEO]
Penny In Yo Pants from Johanna Holtan on Vimeo.
Thought this was a pretty ingenious life hack. All you need is a penny and a hair tie. Now just watch the video, and you can ride and wear a skirt!
Harry Potter VS Twilight Dance Off is Epic! [VIDEO]
This is for all the Harry Potter fans that can't be in Florida for the opening of the extended Wizarding World of Harry Potter. Fan Movies are getting out of control!
Selfies Anonymous Could Help Your Instagram Addiction [VIDEO]
Jet Flies Dangerously Close At Air Show [VIDEO]
Have you ever wanted to see a fighter jet up close and personal? This air show in Waddington, U.K. gave these spectators chance. Like a scene out of Top Gun, the plane screams over the heads of the crowd, only missing them by a few feet.
Real Life Fruit Ninja Cuts Lemons in Record Time [VIDEO]
I played this game once a long time ago. Downloaded it to my phone. It's called 'Fruit Ninja' and it's just addictive. Just like watching this guy slice lemons in real life.
Amusing Squirrel Obstacle Course is Nutty [WATCH]
In the immortal words, from the genius that was the C&C Music Factory. 'It's your world and I'm just a squirrel tryin' to get a nut, so get on the obstacle course'. I think that was it?
What Does It Mean To Do Something #LikeAGirl ? [VIDEO]
If someone said, "You throw like a girl," or, "You run like a girl"? Would they be insulting you?


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Chicago's Carl Mitchell, a.k.a. Twista, isn't a musical or lyrical innovator, but he's got the fastest tongue in hip-hop, and his quick spitting -- and the collaborators he's attracted as a result -- helps explain why his career's on the upswing after nearly a decade in the game. His verbal skills are so freakish that he's essentially an instrument in and of himself, and with 2004's Kamikaze, his fourth disc, he finally found a producer who could make the most of them: Kanye West, who turned "Slow Jamz" into an irresistible hit by revving up a Luther Vandross sample to supersonic speed. The success of the cut helped draw enough talent to The Day After, Twista's latest, to compensate for West's absence, including producers Rodney Jerkins and the Neptunes and guest stars such as Pitbull and "Slow Jamz" alum Jamie Foxx. Yet the disc's most effective track is "Girl Tonite," an erotic exercise co-starring Trey Songz that's more likely to cause pregnancy without physical contact than any David Copperfield magic trick.
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by Stefano Ciarrocchi
published on 2016-07-20
Keywords: Stefano Ciarrocchi, Sculptris, Sibilla, making of
by Hugo Beyer
published on 2015-03-18
Keywords: Wood, sculpt, ZBrush, Maya, texture
by Mathieu Aerni
published on 2015-02-25
Keywords: zbrush, 3ds max, sculpt
Character Production in 3ds Max - Chapter 01
by Rodrigue Pralier
published on 2014-08-22
Keywords: 3dsmax, poly modeling, character


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Merchandise > USA > NY > New York Area
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$550 , mnbff magnificient chow chow puppies male and females 617xx453xx4735Windows Phones · Edison, NJtryuiokujynhgf my three chow chow puppies,1 male and 2 female, (jake is the male,jessy and jully are female) contact me at 617xxx453xx473...Maurine L. · 7 hours ago
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$150 New Full Sized ViolinViolins · Kerhonkson, NYThis is a brand new Skylark 4/4 violin with a lightweight padded nylon case,shoulder strap,bow,and rosin.The violin has a spruce top,stri...
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$275 Brand New 600 Watt Phonic Power AmplifierOther Musical Instruments · Kerhonkson, NYTHIS IS A BRAND NEW PHONIC MAX 860 PLUS 600 WATT POWER AMPLIFIER.THE OUTPUT POWER IS 300 WATTS @ 4 OHMS STEREO , 200 WATTS @ 8 OHMS STERE...
$190 New Left Handed Acoustic GuitarGuitars · Kerhonkson, NYThis is a brand new JBP left handed acoustic guitar.It has a spruce top,nato neck,back and sides,single-ply finger board and body binding...
$500 Yamaha 5.1 Surround Sound Stereo Piano Black Home Speaker System with Sub WooferSpeakers · New York, NYThis is a nearly complete 5.1 surround sound system by Yamaha. This set is in impeccable condition and comes in Piano Black, a coveted an...Reeve H. · 1 week ago
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$60 New Sabian B8 Pro China Splash CymbalCymbals · Kerhonkson, NYThis is a brand new Sabian B8 Pro china splash cymbal.For more information please contact Tim at (845)399-XXXX
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text: Not happy at all with this place. Rooms have equipment that don't work and have to change rooms. The beds are not maintained, there are lights that are out. Radio/CD on the walls are loose and some are hanging by a wire, also they mostly don't work. The stand-up room had no light and was very dangerous to use!! Most of the girls are very snotty, not a nice ambiance at all!!


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The Super ComputerIn general, the speed of supercomputers is measured and benchmarked in "FLOPS" (FLoating Point Operations Per Second), and not in terms of MIPS, i.e. as "Multiple Instructions Per Second", as is the case with general purpose computers. These measurements are commonly used with an SI prefix such as tera-, combined into the shorthand "TFLOPS" (1012 FLOPS, pronounced teraflops), or peta-, combined into the shorthand"PFLOPS" (1015 FLOPS, pronounced petaflops.) The current entry point into the TOP 500 supercomputers is 80 teraflops. The top super computer as of November 2011 is USA's IBM built "Sequoia" computer that runs on POWER processors stands at 20.13 petaflops (20132.7 teraflops).
Academic and Communal Institution Super ComputingIn 2003 Virginia Tech crashed into the Top500 at number 7 with a super computer built if Apple Xserve G5 machines. It ran at 22 teraflops. "System X" (10) as it was known cost US $ 5 million to put together but was bringing in US $ 20-25 million annually. From December 2011, Virgina Tech upgraded their super computer to one called "HokieSpeed" that is built of the "off-the-shelf" technology that any institution or person can quickly build. "HokieSpeed" entered at 96 on the Top500 and cost US $ 1.4 million to build. Virginia Tech's "HokieSpeed" have done a number of things well: (a) It is cost effective. It has 209 nodes, each node with 2 Intel Xeon E5645 6-core CPUs and 2 NVIDIA M2050/C2050 GPUs on a Supermicro 2026GT0TRF Motherboards. All this for US $ 1.4 million for 120 teraflops. (b) It has used standard off-the-shelf hardware and open source software (c) It is top in the "Green List", which is a list of super computers that are most efficient in power consumption. So in essence for US $ 42,000, one should be able to get 6 nodes of this quality at the then prices and at least 4 teraflops. This would not get into the Top500 but all the technology would be HPC compliant and hit a number of milestones.
Placing iHub in the HPC Global CommunityDuring the research into the current HPC arena and how and what iHub can do to get into this space, a number of questions arose that would look into strategic and tactical positioning that would place iHub in good stead among the HPC global community. These are:
- What is iHub's ultimate goal in building the "Cluster"?
- Considering that the cluster can and should pay for itself in 1 to 2 years, what systems and personnel would be required for this outcome to be achieved?
- What benefits will the iHub community and academic institutions interested in utilizing the iHub Cluster system receive?
- Will the cluster in the future be open to serve the needs of the corporate and industrial sectors such as metrological and oil/extraction industries or international research requests from the African region and the Middle East? Considering that there is a business case in development, does the iHub have the necessary structures to cater for this?
- In order to be a respectable HPC system, one needs to enter HPC Top500 list and would need to spend around US $ 500,000 to enter the 80+ teraflops range. This figure will clearly fall in one year's time. Is this a reasonable future aim?


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You missed it This great deal for NakedWines.com is over. But don't despair, we've got more great products every day.
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PAID VALUE EXPIRES ON September 30, 2021
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Hotels near Islington
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Hotels within 1 kilometer of Islington
- Most bookedJackson HouseNo Guest Reviews yet
22 people looked at this hotel in the last hour
20 people looked at this hotel in the last hour
Most recent review
"Everything was Ok,except the flat was cold and the instructions for the heating didnt work.Also the reception staff were rather unhelpful and didnt seem to know what they were doing when check ing us in.However the flat itself was very Nice. Easy access to centre london"
A Traveller, Mar 2016, IE
11 people looked at this hotel in the last hour
Most recent review
"Stayed over night for a friends birthday in central london. Due to the cold weather we didn't walk around the neighbourhood. We were only a few mins walk to Caledonian road tube. We got a cab to Mayfair for £15. We had some nice lunch at the bar below the hotel. The reception staff were very help..."
A Traveller, Nov 2015, GB
- onefinestay - Highbury private homesNo Guest Reviews yet
9 people looked at this hotel in the last hour
- Veeve - Kings Cross ApartmentsNo Guest Reviews yet
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Hotels within 2 kilometers of Islington
184 people looked at this hotel in the last hour
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"I stayed for a night and loved the room as it was very clean with a large comfortable bed. Location is convenient for access due to the proximity of 3 tube stations. I did not have much time to explore the area, but the rooms in this hotel are much better than I expected for the price I paid. Wo..."
A Traveller, Sep 2016, GB
111 people looked at this hotel in the last hour
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"Wanted to be near the Roundhouse, was ideal for being near Camden within walking distance."
A Traveller, Sep 2016, GB
98 people looked at this hotel in the last hour
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"Very good sleep, no issues. Staff very friendly. Great bar and music."
A Traveller, Sep 2016, GB
46 people looked at this hotel in the last hour
Most recent review
"The only drawback here are the shared bathrooms. Internet works fine, they do a nice breakfast as well. I enjoy coming back and consider it one of the best choices for this money anywhere in central/north London."
A Traveller, Sep 2016, GB
18 people looked at this hotel in the last hour
Most recent review
"About the same price as a hotel but has a fridge, washer drier and cooking facilities - which to me makes it so much less claustrophobic than a hotel room. Decor and facilities are very nice and the location is convenient for tubes and busses. Only thing which might be considered a downside is th..."
A Traveller, Nov 2015, US
Map of Islington hotels
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Our map based hotel search can be accessed from the above map image on this page (or via standard search results) and with the locations of each hotel shown clearly around Islington you're able to refine your search within London or United Kingdom based upon other nearby landmarks and neighbourhoods as well as transport options to help you get around. If you're driving be sure to also check the hotels for onsite parking.
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We have Islington hotel deals, even Islington last minute deals and offers to get you the cheap est Islington hotel with our lowest price gaurantee.
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Hi everyone.
The Jakarta Post reported on Jun 25 that several of the local Indonesian airlines is planned to move their operations from Soekarno-Hatta (CGK) airport to the airport's predecessor Halim Perdanakusuma (HLP).
The airlines that are planning to set up operations in HLP includes Citilink, the low cost arm of GA. Batik Air, full service unit of Lion Air. State-owned Merpati is also planned to shift their operations.
As far as I know, HLP is currently used for charter and private flights. In addition to some military and VIP traffic into Indonesia's capital, Jakarta.
Here is the link to the news (in English) :
While I feel it is good move by the Civil Aviation Authority to reduce the overflow of traffic in CGK, I was puzzled that Citilink is one of the carriers shifted to HLP. Wouldn't it be more reasonable if it stays under one roof with its parent Garuda?
Anyone would like to share their views on this issue?
Thank you.


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Thirty Years Later, The History of Western Swing in 26 Minutes as Told by Johnny Gimble
What you'll find after the jump was posted to Vimeo only a few hours ago: a cleaned-up version version of Ken Harrison's 1981 doc on Western Swing fiddle-playing legend Johnny Gimble titled, simply, Gimble's Swing. The film, made for the Tennessee Folklore Society, was exec produced by Blaine Dunlap, another local hero; and it was shot all over, from the late, great Armadillo World Headquarters in Austin to Sumet-Burnet Sound Studio here, the last recording studio in which Bob Wills would ever set foot.
The Tyler-born Gimble, who lives down in Dripping Springs, continues to perform and record: Just last year the 85-year-old cut Celebrating With Friends with the likes of Willie Nelson, Merle Haggard and Vince Gill; it opens with Gimble reminiscing and closes with Garrison Keillor proclaiming him a "national treasure," an understatement. Ray Benson's on the record too, and he shows up toward the end of Gimble's Swing looking like a giant kid granted the opportunity to share a stage with his hero. The whole movie's a 26-minute grin.
Harrison, who made that doc about Angela Hunt's fiddlin'-around great-uncle and 1991's Deep Ellum murder mystery starring Kim Pendleton, uses Gimble to recount the history of Western Swing, including a pit stop at the old WRR. Gimble knew and played with 'em all, from the Light Crust Doughboys to Bob Wills and His Texas Playboys to Jim Boyd, with whom he performs brother Bill and the Cowboy Ramblers' immortal "Under the Double Eagle" in the film, one of its myriad highlights. So jump. You won't be able to help yourself.
Update at 2:38 p.m. Monday: Since the Vimeo version is now unavailable, here's the YouTube take, which is still mighty fine viewin'.
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