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Conventional chemotherapy is commonly used for advanced stages of bladder cancer with modest success and high morbidity. Identifying markers of resistance will allow clinicians to tailor treatment to a specific patient population. T24-tumorigenic cell line was grown orthotopically in nude mice and monitored using bioluminescence imaging and microcomputed tomography until they developed metastases. Stable sublines were then developed from primary bladder (T24-P), lung (T24-L) and bone (T24-B) tissues. Chromosomal analysis and DNA microarray were used to characterize these sublines. qRT-PCR and immunohistochemistry (IHC) were used for validation. Epigenetic modifiers were used to study gene regulation. The cell viability was quantified with MTT assay. Chromosomal analysis revealed multiple alterations in metastatic cell lines compared to T24-P. DNA microarray analysis showed that Taxol-Resistance-Associated-Gene-3 (TRAG3) gene was the most upregulated gene. From qRT-PCR and IHC, TRAG3 was significantly higher in T24-L and T24-B than T24-P. TRAG3 gene expression is likely controlled by DNA methylation, but not histone acetylation. Interestingly, T24-B and T24-L cells were more resistant than T24-P to treatment with anti-microtubule agents such as docetaxel, paclitaxel and vinblastine. TRAG3 mRNA expression was higher in 20% of patients with ≤pT2 (n=10) and 60% of patients with ≥pT3 (n=20) compared to normal adjacent tissue (p=0.05). In addition, the median TRAG3 expression was 6.7-fold higher in ≥pT3 tumors compared to ≤pT2 tumors. Knowing the status of TRAG3 expression could help clinicians tailor treatment to a particular patient population that could benefit from treatment, while allocating patients with resistant tumors to new experimental therapies.
In the United States, urothelial carcinoma of the bladder (UCB) is estimated to affect 68,810 new patients, with 14,100 deaths resulting in 2008 1. Conventional cytotoxic chemotherapy is commonly used as a main regimen for advanced stages of bladder cancer 2. However, frequent appearance of drug resistance due to tumor heterogeneity and serious side effects from current treatment regimens have made treatment outcomes unsatisfactory. It is imperative to identify specific patient populations where particular chemotherapeutic regimens can achieve better therapeutic efficacy, while decreasing the morbidity and mortality related to UCB.
Towards this goal, we designed experiments to study cytogenetic properties and differential gene expression in primary and metastatic UCB cells. We developed a bladder tumor model using nude mice by instilling with human UCB cells orthotopically; the mice initially developed superficial tumors, which are most frequently diagnosed in patients. Subsequently, these tumors became invasive. Bioluminescence imaging (BLI) and Microcomputed tomography (microCT) were used to detect distant metastatic tumors, and sublines were then derived from each metastatic site. While profiling molecular changes associated with metastatic UCB cells, we observed that TRAG3 (Taxol-Resistance-Associated-Gene-3) 3 was the most upregulated gene in metastatic UCB cells. To our knowledge, this is the first study to evaluate TRAG3 in UCB. We further evaluated TRAG3 expression and regulation in cell lines in vitro, the differential growth of UCB cell lines treated with conventional cytotoxic agents, and the expression of TRAG3 in clinical specimens from patients with UCB treated with surgery.
Human TCC cell lines T24 was purchased from the American Type Culture Collection (ATCC, Manassas, VA). Cells were maintained in T medium (Invitrogen, Carlsbad, CA) supplemented with 5% Fetal Bovine Serum and 1% Penicillin/Streptomycin, in a humidified incubator at 37°C with 5% CO2. 5-Azacytidine (5-Aza) was obtained from Sigma (Saint Louis, MO). FK228 (FR901228, Depsipeptide, Romidepsin) was a gift from Fujisawa Pharmaceutical Co., Ltd., Japan. The TRAG3 polyclonal antibody was a gift from Dr. Michael Seiden (Massachusetts General Hospital, Boston, MA). Docetaxel was purchased from Rhône-Poulenc Rôrer, Collegeville, PA and paclitaxel was purchased from CALBIOCHEM, La Jolla, CA. Vinblastine was purchased from American Pharmaceutic Partners, Inc, Schaumburg, IL. Mitomycin, adriamycin, and cisplatin were purchased from Ben Venue laboratory, Inc., Bedford, OH.
T24-t (T24-tumorigenic) cell line, a highly tumorigenic clone, was derived from T24 subcutaneous animal model. To develop a superficial bladder cancer model, T24-t cells was instilled into the bladder as described previously 4. BLI was performed weekly to monitor the growth of primary tumor and subsequent metastases with an injection of 450mg/kg D-luciferin substrate in PBS (Biosynth, Neperville, IL) into anesthetized mice 4. The primary tumor was then excised and plated on tissue culture dishes under the selection of G418 (400 µg/ml) to derive the subline T24-P (T24-Parental).
Lung metastases were visualized using a small-animal microCT scanner (GE eXplore Locus, Piscataway, NJ). Mice were anesthetized with 2% isoflurane and were scanned in prone position. MicroCT imaging was acquired with 400 projections over 7 minutes at 80 kVp and 0.450 mA. The CT images were reconstructed using filtered back-projection and analyzed using the vendor software (MicroView, GE Healthcare, Piscataway, NJ).
Once lung or bone metastases were detected, metastatic tumors were also excised and plated on tissue culture dishes under the same selection conditions to generate lung (T24-L) and bone (T24-B) sublines, respectively. Institutional Animal Care and Usage Committee at the University of Texas Southwestern Medical Center approved all animal experiments.
Cells were seeded in 48-well plates at a concentration of 4 × 103 cells in 0.5 ml of medium per well. After 24 hours, the medium was aspirated and new medium containing different concentrations of drug (Docetaxel: 10, 20, 40, 50, 100 [ng/ml]; vinblastine: 1, 5, 10 [ng/ml]; Mitomycin, Cisplatin, and Adriamycin: 1, 5, 20 [µg/ml]) was added; each treatment condition was carried out in quadruplicate. After 72 hours, total cell number was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (Roche, Indianapolis, IN).
Total cellular RNA was extracted with RNeasy mini kit (Qiagen, Valencia, CA) plus RNase-free DNase I (Qiagen). Total RNA (1 µg) was subjected to cDNA synthesis kit (Bio-Rad, Hercules, CA). The first strand of cDNA (4 µl) was subjected to real-time reverse transcription-PCR (RT-PCR) using primers (TRAG3-forward: 5'-CCAAAGAGGTTCCCAAGACA-3' and TRAG3-reverse: 5'-GCTGTCCGAAAAGAGACTGG-3'). A 50-µL PCR reaction was carried out in iCycler Thermal Cycler (Bio-Rad) using iQ SYBR Green Supermix (Bio-Rad) with a denaturing step at 95°C for 3 minutes followed by 40 cycles of amplification at 95°C for 30 seconds, 56°C for 30 seconds, and 72°C for 1 seconds. The 18S rRNA cDNA [18S F (5'-GGAATTGACGGAAGGGCACCACC-3') and 18S R (5'-GTGCAGCCCCGGACATCTAAGG-3')] was used as an internal control. All experiments were repeated at least twice in duplicate.
Total cellular RNA was prepared from T24-P or T24-L sublines and then subjected to microarray analysis. All RNA-labeling and DNA microarray preparations were performed by The University of Texas Southwestern Medical Center at Dallas-DNA Microarray Core Facility (http://microarray.swmed.edu) using Human Genome U133 Plus2.0 (Affymetrix GeneChip, Santa Clara, CA), and hybridization values were obtained for each spot by using GenePix software. The mean intensity for each gene was obtained in duplicate from each of the replicated experiments, and a compound mean of signal intensity was calculated from four independent spots. Only genes with a 10-folder or higher induction were further validated by qRT-PCR.
High molecular weight genomic DNA was obtained from the indicated cell lines and subjected to bisulfite modification as previously described 5. Briefly, 1–2 µg (5–10 µl) genomic DNA was denatured by NaOH (final concentration, 0.2 M), 30 µl of 10 mM hydroquinone (Sigma), and 520 µl of 3M sodium bisulfite (Sigma) at pH 5 and 50 °C for 8 hrs. Modified samples were purified using Wizard DNA Clean-Up System desalting columns (Promega) followed by ethanol precipitation. Bisulfite-modified DNA (100 ng) was PCR amplified (35 cycles: 95 °C, 30 sec; 54 °C, 30 sec; 72 °C, 1 min) with primer sets described previously 6 in a 25-µl reaction mixture. The PCR products were cloned into TA cloning vector pCR 2.1-TOPO (Invitrogen). Five individual clones were sequenced using reverse and forward M13 primers.
For MSP, Bisulfite-modified DNAs were mixed with 10×PCR Buffer, 150 µM of deoxynucleotide triphosphates, 0.4 µM of primers and 1 unit of HotStarTaq (Qiagen Inc., Valencia, CA). The PCR condition was carried out with 35 cycles of 30 sec of 95°C, 30 sec of 60°C and 1 min of 72°C. The PCR products were resolved by electrophoresis in a 2% agarose gels containing ethidium bromide. Water blanks were included in each assay.
Cells were plated on 8-chamber slides (Nagle Nunc International, Rochester, NY) overnight. For immunostaining, cells were fixed in a solution containing 95% methanol and 5% acetic acid at −20°C for 20 minutes. The endogenous peroxidase activity was blocked with 3% H2O2 in absolute methanol for 30 minutes. After rinsing for 3 times with PBS, the slides were placed in a Universal Block solution (KPL, Gaithersburg, MD) for 20 minutes. Then, the slides were incubated with a polyclonal TRAG3 antibody overnight at 4°C. The tissue sections were further incubated with a peroxidase-conjugated goat anti-rabbit secondary antibody (1:200 dilution in 5% dry milk in 0.01% PBS-T) for 1 h. After several washes with PBS-Tween buffer, the Sigma Fast™ Tablet Set (Sigma, Saint Louis, MO) containing diaminobenzidine (DAB) was used as a chromogen. The positive or negative control is using lung cancer (i.e., A549) treated with 5-aza 15.
All tumor cell lines were grown as monolayer cultures in Minimal Essential Alpha Medium (Invitrogen) supplemented with 10% fetal bovine serum (Invitrogen), L-glutamine (Invitrogen) and antibiotics (Roche). Cells were trypsinized by standard procedures and seeded into 60-mm Petri dishes with sterile coverslips and 5 ml of the same medium for 2–3 days to permit attachment and sufficient growth. Cells were arrested at metaphase with the addition of 25 ml of colcemid to each culture dish and incubate for 25 minutes in a 37°C incubator. Coverslips were manually harvested with hypotonic 0.4% potassium chloride for 20–30 minutes, subjected to multiple treatments with Carnoy's fixative, and allowed to dry in a Thermotron drying chamber. Wright's staining was achieved by treating coverslips for 1.5 to 2 minutes in a trypsin solution diluted 1:50 in Isotin II, rinsing in Gurr buffer pH 6.8 and staining in Wright's stain diluted 1:5 in pHydrion solution for 2 to 3 minutes. Stained slides were mounted cell side down on microscope slides and analyzed on a Nikon E400 microscope. Subsequently, metaphase images were digitally captured and karyotyped with using Applied Spectral Imaging Case Data Manager Version 184.108.40.206 software.
Frozen tissue specimens were obtained from thirty paired samples (tumor and adjacent histologically normal tissue) of bladder cancer patients from our tissue bank. Radical cystectomy was performed in 27 patients, transurethral resection of bladder tumor in 2, and bladder biopsy in 1. All procedures were done at The University of Texas Southwestern Medical Center hospitals. Patients were treated from 1998 to 2002. Twenty-two patients were males and eight were females. Mean patient age was 71.9 years (range 42 – 87). Bladder carcinomas were graded and staged according to the TNM system based on the American Joint Committee on Cancer (AJCC). Genitourinary pathologists determined tumor stage as: Tis (n=2); T1 (n=2); T2 (n=6); T3 (n=13); T4 (n=7). The Institutional Review Board approved the tissue procurement protocol and subsequent studies, and appropriate informed consent was obtained from all patients.
Non-parametric data were summarized using median ± interquartile range and were compared using Mann-Whitney U test. Statistical significance was set at p<0.05. SigmaStat was used for statistical analysis.
We performed BLI (Figure 1a) to non-invasively monitor the growth of bladder tumors in their orthotopic as well as their metastatic locations. Initially, BLI imaging detected tumors in bladder about 4 to 5 weeks after the instillation of T24-t. Subsequently, we established a subline T24-P from these superficial tumors (Figure 1b). Using T24-P, bioluminescence was detected as early as two weeks after instilling cells into the bladder using Angiocath®. Serial monitoring at Weeks 2, 4, 6 documented continued growth of this bladder tumor, eventually resulting in lung metastasis as early as 6 weeks post-instillation (Figure 1a).
We also performed microCT imaging to monitor the development of lung metastasis on Day 42 after injection of T24-P in the bladder. As shown in Figure 1c, microCT successfully detected the 3-D trabecular microarchitecture in vivo. In the microCT images of normal lung, only the bronchi and large vessels can be seen.
Figure 1b shows gross specimens of bladder and lungs with a large burden of bladder tumor, as well as microscopic evaluation of lung tissue with metastatic bladder tumor, using standard hematoxylin and eosin (H&E) stain.
In order to understand the biologic characteristics of these three sublines, we determined their in vitro growth rate. Interestingly, all 3 sublines have a similar growth using the MTT assay (Supplementary data, Figure S1).
In addition, cytogenetic evaluation was performed for T24-P, T24-L, and T24-B. The composite results for these chromosomal analyses are summarized (Supplementary data, Table S1) and a representative karyotype for all three sublines is shown in Figure S2 (Supplementary data). As indicated, the cell lines have very complex karyotypes with numerous numerical and structural abnormalities. The two cell lines derived from metastatic tissue shared most of the same numerical and structural abnormalities seen in the primary cells. This remarkable similarity clearly demonstrates these three cell lines are indeed related. Interestingly, both of the bone and lung sublines revealed simpler karyotypes than those seen in the T24-P cells, having a lower modal chromosome number resulting from the loss of specific chromosomes seen in the primary cells. While the primary cells revealed a modal count of 80–82, the bone and lung cell lines showed modal counts of 58–74 and 74–78, respectively. Chromosome abnormalities specific to the primary cells that are not seen in the metastatic cell lines include extra copies of chromosomes X and 7, as well as three marker chromosomes (mar1, mar2 and mar3), defined as a structurally abnormal chromosome in which no part can be identified, all three of which were seen in 3 of the 5 primary metaphases analyzed and never seen in a bone or lung cell. Specific structural abnormalities seen in primary cells and not in metastatic cells included add(X)(q22), add(2)(p13), add(3)(q13.2), add(5)(q11.2), del(8)(p11) and add(11)(q13). Additionally, while del(15)t(15;22)(p11;q11) was associated with the primary cell line, this aberration appeared only as a nonclonal finding (occurring only once in the metaphases analyzed) in the lung metastatic cell line. Several aberrations were specific to both metastatic cell lines and not seen in the T24-P cells. These were add(19)(p13.1) and add(22)(p11). Additionally, the bone metastatic cell line uniquely revealed an add(1)(q21) and add(1)(q44), and the sole abnormality specific to the lung derived cell line was add(3)(p12). These findings suggest that the metastatic cells are genetically distinct from the parental cell line, and that these are true metastases rather than simple hematogenous spread that occurred during experimental tumor implantation. This observation is consistent with other reports suggesting that metastasis may be associated with particular chromosomal alterations and cells with such potential may derive from "specific" origins 7–9.
Using Affymetrix DNA microarrays, a total of 5,221 genes had ≥2-fold increased expression in T24-L, compared to T24-B. TRAG3 was the most upregulated gene (~115-fold) identified from this array (Table 1). qRT-PCR was used to confirm the expression status of TRAG3 in all three sublines. TRAG3 gene was 223-fold and 588-fold overexpressed in T24-L and T24-B, respectively, as compared to T24-P (Figure 2a). IHC for TRAG3 protein showed that cytoplasmic TRAG3 staining is present at low amount at baseline in T24-P, but this level is increased in T24-L, and to a higher extent in T24-B (Figure 2b).
In order to understand the mechanisms underlying the overexpression of TRAG3 gene in metastatic cell line T24-L, these cells were treated with the DNA hypomethylating agent 5-Aza and the histone deacetylase inhibitor FK228. Treatment with 5-Aza resulted in a significant upregulation of TRAG3 (~35-fold) (Figure 3a), while treatment with FK228 resulted only in minimal upregulation of TRAG3 (~2-fold) (Figure 3b). These data indirectly suggest that TRAG3 expression is partially regulated through epigenetic mechanisms such as DNA methylation, but to a much lesser extent histone acetylation.
However, when we performed bisulfite genomic sequencing and MSP, we noted that DNA methylation pattern on TRAG3 promoter in the three T24-sublines did not correlate with its expression pattern. Moreover, DNA hypomethylation agent (i.e., 5-aza) treatment did not alter the methylation pattern of TRAG-3 gene (Table 2 and Figure 3c), at least in the regions that we studied. These data indicate that promoter methylation status at −71 and −42 position of TRAG-3 gene is not involved in regulating TRAG3 gene expression via DNA methylation. Thus, 5-aza induced TRAG-3 mRNA expression in T24 cells could be an indirect effect. However, we cannot rule out the possibility that additional CpG sites located further 5'-upstream of the TRAG-3 promoter are involved.
Since TRAG3 was initially identified as a taxol-resistance associated gene, we decided to examine the drug sensitivity of these sublines to common chemotherapeutic agents used in UCB patients. Treatment of T24-P, T24-L, and T24-B cell lines with cisplatin, mitomycin, and adriamycin resulted in a similar growth inhibition pattern in all 3 sublines. Conversely, treatment with anti-microtubule agents such as docetaxel, paclitaxel, and vinblastine showed that the sensitivities of the 3 sublines to treatment are distinct, with the parental T24-P cell lines being the most sensitive, followed by T24-L, and T24-B being the most resistant (Figure 4 and Supplementary data Table S2).
We further profiled the TRAG3 expression in UCB patients; thirty patients with paired tumor and normal tissues were included in this study. qRT-PCR showed that 60% of patients with stage ≥pT3 had higher TRAG3 expression in tumors compared to adjacent histologically normal tissue, while only 20% of patients with stage ≤pT2 had higher TRAG3 expression in tumors compared to adjacent histologically normal tissue (p=0.05) (Figure 5a). In addition, the median normalized level of TRAG3 expression in tumor tissue was 6.1 in patients with stage ≥pT3 compared to 0.9 in patients with stage ≤pT2 (Figure 5b).
The American Cancer Society estimated that in 2008, ~14,000 persons will die with UCB 1. Currently, the mainstay of treatment of metastatic UCB is conventional cytotoxic chemotherapy, in the form of MVAC (Methotrexate, Vinblastine, Adriamycin, and Cisplatin) or GC (Gemcitabine and Cisplatin). In this patient population, MVAC regimens result in overall response rates greater than 70%, with 35% of patients achieving complete responses 10, 11. Unfortunately, the median overall survival at 5 years in patients with metastatic UCB treated with chemotherapy (14 months for GC v 15.2 months for MVAC) and the 5-year overall survival rates (13% for GC and 15.3% for MVAC) are poor 12. There is clearly a need for 1) Identifying which patients respond to conventional cytotoxic chemotherapy and 2) Enrolling patients predicted to be unresponsive to conventional cytotoxic chemotherapy in controlled clinical trials evaluating newer therapeutic agents.
The first step in this study was to understand genetic differences between primary and metastatic cell lines. Using an orthotopic model of bladder cancer 4, we were able to observe a similar spectrum of metastatic UCB to the lung and bone. The use of BLI and microCT was instrumental in the non-invasive monitoring of tumor growth in situ in the bladder, and the later development of metastases. After primary and metastatic UCB tissues were harvested, they were grown in vitro, therefore providing ample material for further studies. Cytogenetic evaluation of primary and metastatic UCB cell lines revealed that these cell lines are indeed related, but still exhibit specific cytogenetic abnormalities. The karyotyping results suggest the metastatic cells may arise from clonal expansion. Using DNA microarrays comparing metastatic UCB cells with primary UCB cells, we identified TRAG3 as the most upregulated gene in UCB metastases. A similar approach has been reported previously in UCB, however, in contradistinction to our study, it was used to identify genes that were downregulated in UCB metastases 13. We then confirmed TRAG3 overexpression using standard qRT-PCR and IHC techniques. We noted that TRAG3 expression can be regulated by epigenetic mechanisms such as DNA methylation, as indirectly evidenced by increased expression of TRAG3 when UCB cells were treated with a DNA hypomethylating agent. We also found that T24-L and T24-B sublines with high TRAG3 expression (metastatic UCB) were more resistant to Docetaxel, Paclitaxel, and Vinblastine, compared to T24-P cells with low TRAG3 expression (primary UCB). In clinical specimens, we found that TRAG3 expression was elevated in tumor samples compared to adjacent histologically normal tissues from the same bladder, and was elevated in higher stages of UCB. These results suggest TRAG3 as a potential surrogate marker for predicting drug resistance of anti-microtubule agents in UCB patients with advanced stages.
TRAG3, also known as CSAG2 (Chondrosarcoma Associate Gene 2), was originally identified and described in ovarian cancer 3. A taxol-sensitive ovarian cancer cell line was compared to a taxol-resistant subline using cDNA differential display, which resulted in identifying a novel gene, termed TRAG3. To test the hypothesis that TRAG3 induces resistance in treatment-naïve ovarian cancer cells, TRAG3 cDNA was transfected in these cells, however, no resistance to Taxol was observed, indicating that TRAG3 is a surrogate marker of Taxol resistance, rather than an inducer of resistance 3. Alternatively, it could be one of many components that are involved in Taxol resistance. TRAG3 has been mapped to chromosome Xq28 within a complex coding for the MAGE (Melanoma Antigen Genes) family of tumor antigens 14. Using DNA microarray (Table 1), MAGE gene was significantly upregulated; however, qRT-PCR results indicated that MAGE mRNA is not highly elevated compared with TRAG3 (Supplementary data Figure S3). In addition, the pattern of TRAG3 mRNA upregulation, but not GAGE or MAGE mRNA upregulation, correlates with resistance to anti-microtubule agents in bladder cancer cell lines (Supplementary data Figure S3 and Table S214. It appears that elevated TRAG3 mRNA in bladder cancer cells can better predict their resistance to anti-microtubule agents compared with other chemotherapeutic agents (Supplementary data Table S2).
TRAG3 is usually absent in most normal tissues, except the testis 3, 14. Regulation of TRAG3 expression has been studied in detail in lung carcinoma. Yao et al. studied DNA methylation patterns of TRAG3, and noted that in normal tissues, the CpG islands in the TRAG3 promoter and exon 2 are heavily methylated; with loss of methylation noted in these 2 areas in malignant cells 6. We confirmed that treatment with a DNA hypomethylating agent in UCB resulted in increased TRAG3 expression, similar to reports in lung cancer 6, 15. The expression of TRAG3 mRNA has been previously reported in clinical specimens, including esophageal, liver, bile duct, stomach, breast, and colon cancers 16, as well as cervical cancer 17, melanoma 14, and chondrosarcoma 18. In ovarian cancer, TRAG3 expression has been studied in relation to clinical outcomes after radical surgery and chemotherapy. Patients with low TRAG3 expression had a better progression-free and overall survival compared to those patients with high TRAG3 expression 19.
Future studies should externally validate the current findings of increased TRAG3 expression in UCB. In patients with long-term follow-up after radical cystectomy, TRAG3 should be investigated as a prognostic marker of progression-free survival and overall survival in patients who do not receive chemotherapy. In addition, the ability of TRAG3 expression to predict response after cytotoxic chemotherapy should be investigated in patients with UCB. This could assist in selection of patients that should receive cytotoxic chemotherapy in the neoadjuvant or adjuvant setting in the absence of metastatic disease, or in a salvage setting, in the presence of metastases.
The future treatment of UCB lies in identifying which patients will have the best response to conventional chemotherapy. These patients will be spared the side effects related to ineffective treatment, while allowing them to be enrolled in clinical trials evaluating newer therapeutic agents.
We thank Ms. Mary Barnes for editorial assistance. This work was supported in part by NIH grant CA95730 (to J.T.H.) and small animal imaging research program NIH (U24 CA126608).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Dir. Bruce Malmuth (1981) The American-film debut of Rutger Hauer, playing a terrorist in Malmuth's NYC-set thriller, also features Sylvester Stallone as a cop, sporting a beard and flexing his acting muscle in between Rocky II and Rocky III.
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Machine of Death
Machine of Death
A Collection of Stories about People Who Know How They Will Die
Bearstache Books, Paperback, 9780982167120, 452pp.
Publication Date: October 13, 2010
Machine of Death tells 34 stories about people who know how they will die. The machine doesn't give the date or specifics; using only a blood sample, it just spits out a sliver of paper upon which are printed, in careful block letters, words such as drowned, cancer, old age, or choked on a handful of popcorn. The realization that we could now know how we are going to die changes the world: people became at once less fearful and more afraid. For every possibility the machine closes, it seems to open several more, with varying degrees of plausibility. Over time the machine is reverse-engineered and duplicated. Eventually there are machines in every doctor's office and in booths at the mall. People can pay someone or perhaps get it done for free, but the results are the same no matter which machine is used they are, at least, consistent.
Machine of Death features stories by Randall Munroe, Ben "Yahtzee" Croshaw, Tom Francis, Camille Alexa, Erin McKean, Jeff Stautz, and many others. The book also features illustrations by Kate Beaton, Kazu Kibuishi, Aaron Diaz, Jeffrey Brown, Scott C., Roger Langridge, Karl Kerschl, Cameron Stewart, and many others.
Matthew Bennardo has lived in Cleveland for the past twenty years. His stories have previously been published in Asimov's Science Fiction and Strange Horizons, among other markets.
David Malki ! is the author of the Eisner-, Harvey- and Ignatz-nominated comic strip "Wondermark." His latest collection is Dapper Caps & Pedal-Copters, published by Dark Horse Books. He lives in Los Angeles and he likes to fly airplanes. Read his comics at Wondermark.com.
Randall Munroe, a cartoonist from southern Virginia, is the creator of the webcomic "xkcd" (xkcd.com), one of the most popular comics on the Internet. Formerly a roboticist at NASA, he now makes a living writing comics. He spends his time drawing, traveling, and training computers to beat humans at Rock-Paper-Scissors. He lives in Massachusetts.
Kate Beaton draws men in fancy hats for a living. On an exciting day she'll draw a character with epaulets. Visit her at Harkavagrant.com.
"Machine of Death is a marvelous collection, riddled with intelligence, creative reach, and a frankness that makes the best use of the central gimmick." Tasha Robinson, The Onion A.V. Club
"For an anthology that deals with the inevitability of death, Machine of Death is a lot of fun. The editors knew not to start off heavy, nor does the tone of the anthology lean too long in any direction, providing a lot of singular entertainment for the reader . . . Highly engaging, interestingly crowdsourced, and crafted with a great deal of care. You'll be thinking about it long after you're through reading." Chris Greenwood, TOR.com
"The only consistent entity is the presence of the Machine of Death; the appearance of the machine, the depth of its integration into culture, and peoples' responses to it and its predictions vary from story to story. This is both wonderful and frustrating each story offers up a uniquely interesting take on the Machine of Death, which is impressive, but sometimes I found myself so taken in by one writer's universe that I wanted it to serve as canon to the rest of the book. It's not a bad complaint to have, and it's the only one I can muster . . . The book is just too good to pass up." Andrew Cunningham, Charge Shot!!!
"Picking just one good story in the Machine of Death anthology is like any of its characters escaping their foretold deaths impossible." Rating: 4/4 Christine Cabalo, Hawaii Marine
"Recalls the best writings of Harlan Ellison and Charles Beaumont and easily one of the most engaging slices of short stories I've had the pleasure to read in quite a long while. After all the years of picking up short story collections that inevitably disappoint, Machine of Death brought me laughs, terror and tears . . . Highly recommended." Maurice Greenwood, Paradox Magazine


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Steve Lomas
|Personal information
|Full name
|Stephen Martin Lomas[1]
|Date of birth
|18 January 1974
|Place of birth
|Hanover, Germany
|6 ft 0 in (1.83 m)
|Playing position
|Senior career*
|Manchester City
|West Ham United
|Queens Park Rangers
|St Neots Town
|National team
|Northern Ireland
|Teams managed
|St Neots Town
|St Johnstone
* Senior club appearances and goals counted for the domestic league only.
Stephen Martin "Steve" Lomas (born 18 January 1974) is a Northern Irish former professional footballer and was most recently manager of Football League Championship club Millwall.
As a player he was a midfielder from 1991 to 2010. He had spells in the Premier League for both Manchester City and West Ham United before moving into the Football League with Queens Park Rangers and Gillingham. In 2009 he became player-manager of Non-league side St Neots Town. Lomas was capped 45 times by Northern Ireland, scoring 3 goals.
Lomas was appointed manager of Scottish Premier League club St Johnstone in 2011. He guided them to UEFA Europa League qualification places in 2011–12 and 2012–13. He moved to Championship club Millwall in June 2013.
He is a nephew of the former Manchester United and Northern Ireland goalkeeper Harry Gregg.[2]
Club career[edit]
Lomas, a midfielder, first made his name with Manchester City after joining them in 1991. He soon broke into the first team but will often be remembered at the club for his misfortune of scoring an own goal on the last day of the 1995–96 season, which meant that City could only manage a 2–2 draw at home to Liverpool and were relegated from the Premier League on goal difference.[3]
He then moved to West Ham United in 1997 for a fee of £2.5 million.[4] He made his West Ham debut on 9 April 1997 in a 0–0 draw with Middlesbrough; his first goal coming on 3 December 1997 in a 4–1 defeat of Crystal Palace.[4] He made 227 competitive appearances, scoring 13 goals,[4] became club captain and was a member of the West Ham team which won the Intertoto Cup in 1999.[5]
On 31 August 2005, he was released on a free transfer and joined Queens Park Rangers.[6]
He left QPR in May 2007, and joined Gillingham on 31 July 2007.[7] On 9 January 2008, Gillingham manager Mark Stimson revealed that Lomas had been placed on the transfer list.[8] On 31 January it was announced that Lomas had been released from his contract.[9]
International career[edit]
Lomas was born in Hanover, Germany, his father was a soldier stationed there. As a child he briefly lived in Hong Kong, before moving to Coleraine, Northern Ireland at the age of two.[10] He earned 46 caps for the Northern Ireland national team, scoring three goals.
Managerial career[edit]
After leaving Gillingham, Lomas took up a coaching role at Norwich City before managing St Neots Town.[11] from 23 March 2009, until July 2010, leading the club to their most successful season for 40 years.[12] He left the club briefly in January 2010, following the departure of chairman John Delaney, but returned after Delaney had been reinstated as Chairman. Lomas resigned from St Neots in July 2010 to pursue his ambition to manage at a league club. At the end of February 2011 he accepted the position of reserve team manager at West Ham United.[13]
St Johnstone[edit]
In November 2011, Lomas signed a two-and-a-half year deal to manage Scottish Premier League side St Johnstone following the departure of Derek McInnes to English Championship team Bristol City. Shortly after signing the deal to become first team manager he was joined by former Northern Ireland goalkeeper and Lisburn Distillery manager Tommy Wright who had agreed to join the club as an assistant to Lomas.[14] In his first season as manager of St Johnstone, Lomas took the club to a top 6 finish for the first time since 1999.[15]
After Hearts won the Scottish Cup, St Johnstone also qualified for the Europa League, entering the competition in the second qualifying round.[16] Initially there was confusion about who their opponents would be, because of an appeal to CAS by Turkish club, Besiktas, who had been banned from this season's European competition by UEFA.[17] Turkish club, Eskisehirspor were, however, confirmed as opponents of St Johnstone with the first leg to be played in Turkey on 19 July and the second leg at home at McDiarmid Park, Perth on 26 July 2012.[18]
Despite a slow start to the 2012–13 season after many changes to the squad – 12 players were out of contract during the summer – St Johnstone had an excellent September, drawing with Dundee United and winning the next four matches, the first against Celtic, ending Ross County's 40 game unbeaten run and beating rivals Dundee, as well as reaching the quarter finals of the Scottish League Cup. On 4 October 2012, Lomas was named SPL Manager of the month, the first time a St Johnstone manager had won the award.[19] On beating the Manager of the Month "curse" in October to record 5th and 6th straight wins against St Mirren and Kilmarnock, Steve Lomas achieved the best run of results at St Johnstone since 1971,[20] reaching 2nd place in the SPL table behind Celtic.[21]
In October 2012, Lomas' name began to be linked with vacant manager's positions in English clubs; first at Bournemouth,[22] then Burnley,[23] Fleetwood [24] Doncaster Rovers [25] and Coventry City.
Lomas achieved a second successive top six SPL finish with a game to spare, and on the last game of the season on 19 May 2013, in his first full season in charge, a 2–0 victory over Motherwell gave St Johnstone 3rd place in the SPL and Europa League qualification, the first time in their history that St Johnstone had gained back to back European qualification.[26]
On 5 June 2013, Millwall made an official approach to speak with Lomas about the vacant managerial position.[27] His appointment as manager was announced on 6 June.[28] Lomas was sacked on 26 December 2013 after the ten men of Millwall lost to Watford.[29] Lomas' tenure at Millwall had been up and down. He had won six of 24 games as manager of Millwall but these included wins against higher placed teams such as Blackpool, Leeds and Wigan and he was nominated for the September SkyBet Championship Manager of the Month award [30] after winning 3 games in a row. Lomas had also drawn 6 including QPR, Burnley, Reading and Nottingham Forest.[31][32] Inheriting a team which finished one point above the relegation places on the last day of the 2012-13 season, however, Lomas was unable to achieve a dramatic turnaround in performance and left with the club one place above that in 20th position and 4 points above the relegation places.[33]
- West Ham United
Managerial statistics[edit]
|Win %
|St Neots Town
|March 2009
|July 2010
|St Johnstone
|3 November 2011
|6 June 2013
|6 June 2013
|26 December 2013
- ^ Hugman, Barry J. (ed) (2008). The PFA Footballers' Who's Who 2008–09. Mainstream. ISBN 978-1-84596-324-8.
- ^ [1]
- ^ LIVERWEB – Liverpool Results 1995–96
- ^ a b c "Welcome to the Wonderful World of West Ham United Statistics Steve Lomas". www.westhamstats.info. Retrieved 2010-11-23.
- ^ a b "Sport: Football Intertoto win gives Hammers Uefa spot". BBC Sport. Retrieved 26 April 2015.
- ^ "Lomas signs". www.qpr.co.uk. 2005-09-06. Retrieved 2010-11-23.
- ^ Official Gillingham website
- ^ "Exclusive:Nine players available for transfer". Gillingham F.C. 2008-01-19. Retrieved 2008-01-09.
- ^ "Exclusive:Lomas, Graham and Armstrong all depart". Gillingham F.C. 2008-01-31. Retrieved 2008-02-01.
- ^ English, Tom (18 December 2011). "No oasis of calm". Scotland on Sunday – via Highbeam (subscription required). Retrieved 20 February 2014.
- ^ St Neots Town FC Official Website Archived 5 November 2011 at the Wayback Machine.
- ^ St Neots Town FC Official Website[dead link]
- ^ "Lomas returns | News | Latest News | News | West Ham United". Whufc.com. Retrieved 2011-03-04.
- ^ "St Johnstone confirm Steve Lomas as manager". BBC Sport. Retrieved 3 November 2011.
- ^ "St Johnstone 2 – 1 Hearts: Saints secure top-six slot".
- ^ "Premier League and Football League: Ups and downs".
- ^ "St Johnstone face Eskisehirspor unless Besiktas win appeal". Daily Mail. London. 25 June 2012.
- ^ "Eskisehirspor confirmed as St Johnstone's Euro opponents".
- ^ "St Johnstone's Steve Lomas named SPL Manager of the Month for September".
- ^ "St Johnstone boss Steve Lomas Praises record-equalling side".
- ^ "St Johnstone boss Steve Lomas: Second place is pleasing.. but it could be even better".
- ^ "Bournemouth: Steve Cotterill return is unlikely".
- ^ "Lomas into Turf Frame".
- ^ Jones, Simon (4 December 2012). "Lomas Leading the way to replace Mellon at League Two Fleetwood". Daily Mail. London.
- ^ "St Johnstone Boss set for Doncaster move after Harry Redknapp Recommendation".
- ^ "Heaven and Perth".
- ^ "Official Approach For Lomas".
- ^ "Steve Lomas: Millwall appoint St Johnstone manager". BBC Sport. 2013-06-06. Retrieved 2013-06-07.
- ^ "Millwall: Steve Lomas sacked after Watford defeat on Boxing Day". BBC Sport. 26 December 2013. Retrieved 27 December 2013.
- ^ "Manager of the Month nominations". The Football League. Retrieved 16 January 2014.
- ^ a b "Soccerbase - managerial statistics". www.soccerbase.com. Retrieved 27 December 2013.
- ^ "Millwall Results". Retrieved 2013-12-27.
- ^ "League Table". Retrieved 2013-12-27.
External links[edit]
- 1974 births
- Living people
- Sportspeople from Hanover
- Association football midfielders
- Association footballers from Northern Ireland
- Northern Ireland international footballers
- Manchester City F.C. players
- West Ham United F.C. players
- Queens Park Rangers F.C. players
- Premier League players
- English Football League players
- Gillingham F.C. players
- St Neots Town F.C. players
- British association football commentators
- West Ham United F.C. non-playing staff
- St Johnstone F.C. managers
- Scottish Premier League managers
- Millwall F.C. managers
- English Football League managers
- Football managers from Northern Ireland


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From bestselling authors Jason Hazeley and Joel Morris - a nugget of wisdom in the phenomenal Ladybirds for Grown Ups series. This delightful book is the latest in the series of Ladybird books which have been specially planned to help grown-ups with the world about them. The large clear script, the careful choice of words, the frequent repetition... more...
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In terms of items the equipment used by Fletcher seems basic as we only get two guns… as the game progresses though we discover that it is much more that "just two guns". Fletcher is initially equipped with an assault rifle and a plasma rifle, an energy weapon and a solid projectile firing weapon. As we progressed through the game we pick up N.A.N.O (in game currency) which can be used at upgrade booths. Each weapon type has five modifications and each mod has a primary fire upgrade and a secondary fire upgrade. This means that the game has much more variation than it first seems and although the overall look of the weapon stays the same the use changes significantly. The assault rifle for example gets an extra section added to make it into a combat shotgun, rocket launcher, grenade launcher and proximity mine launcher. Similarly the plasma rifle can be modified into a shock blaster, particle cannon, electric mortar and smartgun.
Of course each weapon has its pros and cons and picking the right gun for the fight can make a big difference.
As well as modifying the weapons at the upgrade booth it is also possible to improve health, shield and ammo. Additionally a Tactical Scanner can be purchased and the Hard Reset version of "bullet time" can be enabled and improved in the same way. In total we are given three distinct areas to change with five specific modifications all with two additional upgrade. In all there are some forty five difference tweaks to the basic weapons and stats that we feel will satisfy any gaming style and help the player create a screen shaking, colourful, sensory assault of metallic gore.
Sadly this is not a game that can be played over and over as it has no multi player option or varied levels/outcomes, it is very much is a play once and then put away title.
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We cannot emphasis enough how impressed we are with the graphics, when we compare it to the recently released Deus Ex Human Revolution, which is also visually good and styled in a similar way, we find Hard Reset is better. It is the level of detail that the constant way we can damage every that really moves this game close to a cinematic experience.
That said, one part of the graphics seems incomplete and doesn't work with the rest of the game and this is the button press graphic. It's a little white hand, the kind we get when we hover over link or image on the internet. We forgave this lack of graphical judgment when we previewed the game as we hoped that it would be changed in the full game but alas it was not to be the case.
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However the game has a flaw, it does become a little repetitive and more variation of gameplay would have been appreciated. We completed the game in 6 hours, which is fine as this is not a full price title, and by the end the player will feel that anything more would have been a chore to play through. This typifies Hard Reset. It is a game that looks amazing but doesn't bring anything new. It does this very well, borrowing ideas from the best FPS titles but suffers a little through not having its own.
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Describing something as the best, without a doubt. Similar to 'hands down'
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On what the Memphis game means to him personally:
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text: Primoris Services Corp. Company Profile (NASDAQ:PRIM) Analyst Ratings Earnings Estimates Dividends Insider Trades Headlines Social Company Profile Chart About Primoris Services Corp. Primoris Services Corporation is a holding company. The Company holds various subsidiaries, through which it operates as a specialty contractor and infrastructure company. It operates in three segments: the West Construction Services segment (West segment), the East Construction Services segment (East segment) and the Energy segment. The West segment includes underground and industrial operations, and construction services performed by ARB, Inc., ARB Structures, Inc., Rockford Corporation, Q3C and Vadnais. The East segment includes the JCG Heavy Civil division, the JCG Infrastructure and Maintenance division, BW Primoris and Cardinal Contractors, Inc. construction business. 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Industry, Sector and Symbol: Sector: Construction Industry: Heavy Construction Sub-Industry: Construction & Engineering Exchange: NASDAQ Symbol: PRIM CUSIP: 74164F10 Key Metrics: Previous Close: $20.2350 Day Moving Average: $18.87200 Day Moving Average: $20.6252-Week Range: $16.13 - $25.25Trailing P/E Ratio: 26.44Foreward P/E Ratio: 16.54P/E Growth: 2.70Market Cap: $1.04BOutstanding Shares: 51,784,000Beta: 1.66Profitability:Net Margins: 2.03%Return on Equity: 8.14%Return on Assets: 3.50%Debt:Debt-to-Equity Ratio: 0.41%Current Ratio: 1.63%Quick Ratio: 1.47% Additional Links: Visit Primoris Services Corp.'s Official WebsiteView PRIM on Google FinanceView PRIM on Yahoo FinanceView PRIM's Company Profile on ReutersSearch for Primoris Services Corp. on Google Companies Related to Primoris Services Corp.:Norbord (NYSE:OSB)Tri Pointe Homes (NYSE:TPH)KBR (NYSE:KBR)Universal Forest Products (NASDAQ:UFPI)GCP Applied Technologies (NYSE:GCP)Granite Construction (NYSE:GVA)Advanced Drainage Systems (NYSE:WMS)Trex (NYSE:TREX)Potlatch Corp. (NASDAQ:PCH)AAON (NASDAQ:AAON) Analyst Ratings Consensus Ratings for Primoris Services Corp. (NASDAQ:PRIM) (?) The ratings breakdown includes the most recent rating from each analyst that has rated the stock within the last twelve months. The ratings score is a calculation of the average number of sell, hold, buy and strong buy ratings (0-1.5 = Sell, 1.5-2.5 = Hold, 2.5-3.5 = Buy, >3.5 = Strong Buy). The consensus price target is a mean average of the most recent price target set by each analyst that has set a price target for the stock in the last twelve months.Ratings Breakdown: 2 Hold Ratings, 3 Buy RatingsConsensus Rating:Buy (Score: 2.60)Consensus Price Target: $25.50 (26.36% upside) Analysts' Ratings History for Primoris Services Corp. (NASDAQ:PRIM) Show: All Ratings For This Stock Only the Most Recent Rating From Each Brokerage DateFirmActionRatingPrice TargetDetails8/25/2016Seaport Global SecuritiesUpgradeNeutral -> Buy$20.00 -> $24.008/4/2016DA DavidsonDowngradeBuy -> Neutral5/6/2016Canaccord GenuityReiterated RatingHold4/21/2016Avondale PartnersReiterated RatingOutperform11/12/2015WunderlichBoost Price TargetBuy$23.00 -> $26.0012/1/2014BB&T Corp.DowngradeBuy -> Hold(Data available from 9/27/2014 forward) Earnings Earnings History for Primoris Services Corp. (NASDAQ:PRIM)DateQuarterConsensus EstimateActual EPSRevenue EstimateActual RevenueRelease LinkConference CallDetails11/3/2016 8/4/2016Q216$0.22$0.10$516.76 million$456.81 millionViewN/A5/5/2016Q116$0.06$0.05$423.00 million$430.40 millionViewN/A2/25/2016Q415$0.30$0.24$527.72 million$497.10 millionViewListen11/5/2015Q315$0.37$0.37$599.28 million$555.90 millionViewListen8/6/2015Q215$0.19$0.07$494.81 million$483.50 millionViewListen5/5/2015Q115$0.13$0.03$434.40 million$392.80 millionViewListen3/3/2015Q414$0.49$0.17$622.96 million$487.60 millionViewListen11/6/2014Q314$0.49$0.53$599.03 million$613.20 millionViewListen8/7/2014Q214$0.31$0.31$503.10 million$515.00 millionViewN/A5/6/2014Q114$0.20$0.21$460.95 million$470.00 millionViewN/A2/28/2014Q413$0.39$0.44$541.11 million$537.90 millionViewN/A11/5/2013Q313$0.42$0.42$513.78 million$551.30 millionViewN/A8/7/2013Q2 2013$0.29$0.30$451.20 million$445.00 millionViewN/A5/29/2013Q1 13$0.18$0.19ViewN/A5/7/2013Q1 2013$0.18$0.19$352.60 million$410.00 millionViewN/A3/7/2013Q4 2012$0.30$0.33$402.81 million$480.80 millionViewN/A11/6/2012Q312$0.33$0.34$408.53 million$431.80 millionViewN/A8/8/2012$0.22$0.23ViewN/A5/9/2012$0.24$0.20ViewN/A3/1/2012$0.22$0.35ViewN/A11/8/2011$0.20$0.38ViewN/A8/4/2011$0.24$0.28ViewN/A5/10/2011$0.22$0.24ViewN/A3/16/2011$0.22$0.24ViewN/A(Data available from 1/1/2011 forward) Estimates Earnings Estimates for Primoris Services Corp. (NASDAQ:PRIM)Current Year EPS Consensus Estimate: $0.75 EPSNext Year EPS Consensus Estimate: $1.22 EPSQuarterNumber of EstimatesLow EstimateHigh EstimateAverage EstimateQ1 20165$0.05$0.20$0.12Q2 20165$0.20$0.31$0.25Q3 20164$0.20$0.46$0.35Q4 20165$0.34$0.47$0.41Q1 20171$0.15$0.15$0.15Q2 20171$0.28$0.28$0.28Q3 20171$0.43$0.43$0.43Q4 20171$0.55$0.55$0.55(Data provided by Zacks Investment Research) Dividends Current Dividend Information for Primoris Services Corp. (NASDAQ:PRIM)Annual Dividend:$0.22Dividend Yield:1.09%Payout Ratio:28.95% (Based on Trailing 12 Months of Earnings) 29.33% (Based on Current Year Consensus EPS Estimate)18.03% (Based on Next Year Consensus EPS Estimate)Dividend History for Primoris Services Corp. (NASDAQ:PRIM)AnnouncedPeriodAmountYieldEx-Dividend DateRecord DatePayable Date8/4/2016quarterly$0.061.22%9/28/20169/30/201610/14/20165/6/2016quarterly$0.060.97%6/28/20166/30/20167/15/20162/26/2016quarterly$0.061.04%3/29/20163/31/20164/15/201611/9/2015quarterly$0.061.03%12/29/201512/31/20151/15/20168/7/2015quarterly$0.061.22%9/28/20159/30/201510/15/20155/6/2015quarterly$0.061.15%6/26/20156/30/20157/15/20153/6/2015quarterly$0.040.93%3/27/20153/31/20154/15/201511/4/2014quarterly$0.040.7%12/29/201412/31/20141/15/20158/7/2014quarterly$0.040.56%9/26/20149/30/201410/15/20145/6/2014quarterly$0.040.49%6/26/20146/30/20147/15/20145/6/2014quarterly$0.046/30/20146/15/20142/28/2014quarterly$0.040.45%3/27/20143/31/20144/15/201411/6/2013quarterly$0.040.5%12/27/201312/31/20131/15/20148/8/2013quarterly$0.040.62%9/26/20139/30/201310/15/20135/8/2013quarterly$0.040.65%6/26/20136/28/20137/15/20133/7/2013quarterly$0.030.59%3/26/20133/29/20134/15/2013(Data available from 1/1/2013 forward) Insider Trades Insider Trading History for Primoris Services Corp. (NASDAQ:PRIM)Insider Ownership Percentage: 23.10%Institutional Ownership Percentage: 74.49%Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionDetails9/30/2014Thomas E TuckerDirectorSell2,000$27.19$54,380.00 6/27/2014Thomas E TuckerDirectorSell2,000$29.06$58,120.00 5/20/2014Brian PrattCEOSell745,000$28.15$20,971,750.00 3/21/2014Michael KillgoreVPSell8,480$31.16$264,236.80 3/18/2014Eric RosenfeldDirectorSell71,900$31.04$2,231,776.00 3/7/2014Brian PrattCEOBuy3,864$21.57$83,346.48 3/7/2014John PerisichVPBuy2,512$21.57$54,183.84 3/7/2014Peter MoerbeekCFOBuy2,898$21.57$62,509.86 3/5/2014Eric RosenfeldDirectorSell21,840$32.45$708,708.00 12/5/2013Thomas TuckerDirectorSell6,965$21.27$148,145.55 11/26/2013Eric RosenfeldDirectorSell3,122$28.60$89,289.20 9/6/2013Michael D KillgoreVPSell15,000$23.85$357,750.00 9/4/2013Eric RosenfeldDirectorSell9,474$23.00$217,902.00 8/26/2013Eric RosenfeldDirectorSell10,526$23.13$243,466.38 8/22/2013Eric RosenfeldDirectorSell80,000$22.87$1,829,600.00 6/28/2013Eric RosenfeldDirectorSell13,174$19.96$262,953.04 6/17/2013Brian PrattCEOSell824,400$20.18$16,636,392.00 5/24/2013Michael D KillgoreVPSell20,000$21.41$428,200.00 5/16/2013Michael D KillgoreVPSell20,000$21.26$425,200.00 3/13/2013Perisich Family Trust Dated JuInsiderBuy4,538$11.02$50,008.76 3/13/2013Peter J MoerbeekCFOBuy5,294$11.02$58,339.88 11/23/2012Eric RosenfeldDirectorSell20,348$14.51$295,249.48 11/13/2012Thomas E TuckerDirectorSell9,000$14.07$126,630.00 9/14/2012Brian PrattCEOSell122,981$13.14$1,615,970.34 (Data available from 1/1/2013 forward) Headlines Latest Headlines for Primoris Services Corp. (NASDAQ:PRIM)DateHeadlinePrimoris Services Corporation : Announces Industrial Award Valued at $15 Million (NASDAQ:PRIM)www.4-traders.com - September 26 at 6:55 PMWidow's appeal of pipeline survey to test property rights amendment (NASDAQ:PRIM)www.dailyprogress.com - September 22 at 6:33 PMAtlantic Coast Pipeline hires main construction contractor (NASDAQ:PRIM)www.ogj.com - September 22 at 6:33 PMPrimoris Services Corporation Announces Industrial Award Valued at $15 Million (NASDAQ:PRIM)finance.yahoo.com - September 22 at 11:41 AMPrimoris' (PRIM) Unit Signs Construction Contract with ACP (NASDAQ:PRIM)finance.yahoo.com - September 22 at 11:41 AMConstruction contract signed for Atlantic Coast Pipeline (NASDAQ:PRIM)www.newsplex.com - September 21 at 6:28 PMNew Market Research Report: Primoris Services Corporation (PRIM) - Oil & Gas - Deals and Alliances Profile (NASDAQ:PRIM)www.live-pr.com - September 15 at 10:23 AMMUD will keep using outside firm on gas mains (NASDAQ:PRIM)www.omaha.com - September 9 at 11:37 AMPrimoris Services Corporation Announces Underground Award Valued at $45 Million and Provides Update on Florida Pipeline Projects (NASDAQ:PRIM)finance.yahoo.com - September 6 at 11:40 AM8:15 am Primoris Services announces the extension of two Master Service Agreements valued at $45 mln; provides Florida pipeline project update (NASDAQ:PRIM)finance.yahoo.com - September 6 at 11:40 AMBRIEF-Primoris Services Corp announces underground award valued at $45 mln (NASDAQ:PRIM)feeds.reuters.com - September 6 at 9:39 AMPrimoris Services (PRIM) Catches Eye: Stock Jumps 6.7% (NASDAQ:PRIM)finance.yahoo.com - August 26 at 9:52 AMPrimoris Services upgraded by Seaport Global Securities (NASDAQ:PRIM)finance.yahoo.com - August 25 at 12:00 PMPrimoris Services Corp. breached its 50 day moving average in a Bullish Manner : PRIM-US : August 24, 2016 (NASDAQ:PRIM)www.capitalcube.com - August 24 at 9:57 AMShares of PRIM Down 19.6% Since Downtrend Call on Shares (NASDAQ:PRIM)www.mysmartrend.com - August 18 at 7:07 PMPRIMORIS SERVICES CORP Financials (NASDAQ:PRIM)finance.yahoo.com - August 18 at 7:07 PMETF's with exposure to Primoris Services Corp. : August 16, 2016 (NASDAQ:PRIM)www.capitalcube.com - August 16 at 7:03 PMDeepMarkit Engages Primoris Group Inc. for Media Relations (NASDAQ:PRIM)virtual-strategy.com - August 15 at 7:19 PMPrimoris Services Corporation : Announces Heavy Civil Award Valued at $16 Million (NASDAQ:PRIM)www.4-traders.com - August 15 at 7:19 PMPrimoris Services Corp. :PRIM-US: Earnings Analysis: Q2, 2016 By the Numbers : August 15, 2016 (NASDAQ:PRIM)www.capitalcube.com - August 15 at 7:19 PMPrimoris Services Corporation Announces Heavy Civil Award Valued at $16 Million (NASDAQ:PRIM)finance.yahoo.com - August 11 at 10:11 AMEdited Transcript of PRIM earnings conference call or presentation 4-Aug-16 3:30pm GMT (NASDAQ:PRIM)finance.yahoo.com - August 5 at 7:08 PMBRIEF-Primoris Services Q2 earnings per share $0.10 (NASDAQ:PRIM)www.reuters.com - August 4 at 7:25 PMPrimoris Services Corporation: Primoris Services Corporation Announces 2016 Second Quarter Financial Results (NASDAQ:PRIM)www.twst.com - August 4 at 7:25 PMPrimoris Services misses Street 2Q forecasts (NASDAQ:PRIM)sg.finance.yahoo.com - August 4 at 10:04 AMPrimoris Services misses by $0.12, misses on revenue (NASDAQ:PRIM)seekingalpha.com - August 4 at 7:42 AMSmooth driving ahead in Atascadero as gas pipeline project wraps up (NASDAQ:PRIM)www.sanluisobispo.com - August 1 at 6:40 PMPrimoris Services Corporation Schedules Release of 2016 Second Quarter Financial Results and Conference Call (NASDAQ:PRIM)www.publicnow.com - July 15 at 5:48 PMPrimoris Services Corporation (PRIM) Ex-Dividend Date Scheduled for (NASDAQ:PRIM)www.nasdaq.com - June 27 at 11:02 AMEx-Dividend Reminder: Primoris Services, Illinois Tool Works and Stantec (NASDAQ:PRIM)www.nasdaq.com - June 24 at 6:58 PMPrimoris Services (PRIM) Shares Cross Below 200 DMA (NASDAQ:PRIM)www.nasdaq.com - June 11 at 9:48 AMOversold Conditions For Primoris Services (PRIM) (NASDAQ:PRIM)www.nasdaq.com - June 10 at 7:12 PM5 Stocks That Could Raise Their Dividends (NASDAQ:PRIM)www.fool.com - June 2 at 12:11 PMPrimoris Services Corporation Announces Pipeline Construction Award Valued at $15 Million (NASDAQ:PRIM)www.publicnow.com - June 2 at 7:55 AMAre Analysts Bearish Primoris Services Corp (NASDAQ:PRIM) After Last Week? - HNN (NASDAQ:PRIM)hintsnewsnetwork.com - May 30 at 1:29 PMAnalysts Set 1-Year Price Target Of $26.3 On Primoris Services Corporation (NASDAQ:PRIM) Stock - Investor Newswire (NASDAQ:PRIM)www.investornewswire.com - May 29 at 12:59 PMHold Calls Count For Primoris Services Corporation (NASDAQ:PRIM) At 4 - Stocks Daily (NASDAQ:PRIM)www.stocksdaily.net - May 28 at 1:09 PMPrimoris Services Corp. :PRIM-US: Earnings Analysis: Q1, 2016 By the Numbers (NASDAQ:PRIM)www.capitalcube.com - May 16 at 11:40 AMPRIMORIS SERVICES CORP Files SEC form 8-K, Results of Operations and Financial Condition, Submission of Matters to a (NASDAQ:PRIM)biz.yahoo.com - May 6 at 5:20 PMPRIMORIS SERVICES CORP Files SEC form 10-Q, Quarterly Report (NASDAQ:PRIM)biz.yahoo.com - May 6 at 5:17 PMEdited Transcript of PRIM earnings conference call or presentation 5-May-16 2:00pm GMT (NASDAQ:PRIM)finance.yahoo.com - May 6 at 2:24 PMETF's with exposure to Primoris Services Corp. : May 5, 2016 (NASDAQ:PRIM)www.capitalcube.com - May 5 at 5:47 PMBRIEF-Primoris Services Q1 EPS $0.05 (NASDAQ:PRIM)feeds.reuters.com - May 5 at 8:36 AMPrimoris Services misses 1Q profit forecasts (NASDAQ:PRIM)finance.yahoo.com - May 5 at 8:25 AMPrimoris Services Corporation Announces 2016 First Quarter Financial Results (NASDAQ:PRIM)www.publicnow.com - May 5 at 8:01 AMQ1 2016 Primoris Services Corp Earnings Release - Before Market Open (NASDAQ:PRIM)biz.yahoo.com - May 5 at 7:07 AMPrimoris Services Corp. breached its 50 day moving average in a Bearish Manner : PRIM-US : May 4, 2016 (NASDAQ:PRIM)www.capitalcube.com - May 4 at 8:42 AMPrimoris Services Corporation Announces Heavy Civil Award Valued at $22 Million (NASDAQ:PRIM)www.publicnow.com - April 28 at 8:08 AMPrimoris Services Corporation Schedules Release of 2016 First Quarter Financial Results and Conference Call (NASDAQ:PRIM)www.publicnow.com - April 20 at 7:51 AMPrimoris Services Corporation Announces Heavy Civil Awards Valued at $44 Million (NASDAQ:PRIM)finance.yahoo.com - February 29 at 7:30 AM Social Primoris Services Corp. (NASDAQ:PRIM) Chart for Tuesday, September, 27, 2016 Last Updated on 9/27/2016 by MarketBeat.com Staff


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Fairy Blossoms #1: Daisy and the Magic Lessonby Suzanne Williams Fiona Sansom
At Mistress Lily's Fairy School, Daisy is learning to be a fairy helper to humans-and she makes the most wonderful new friends! Violet can turn invisible. Poppy can shape-shift. Marigold can change her wings to match her clothes. Daisy doesn't know any magic at all, but she gets a chance to discover her own special talent when a human in trouble needs the fairies' help!
Fairy Blossoms #2: Poppy and the Vanishing Fairyby Suzanne Williams Fiona Sansom
Mistress Lily is gone for the day, and Poppy hopes she'll hurry home. Then Mistress Lily doesn't come back on time-something must be wrong! With the help of their flying ponies, Poppy and her friends set off to find out what's happened to their teacher. They discover a magical creature and a mysterious enchantment!
Fairy Blossoms #3: Rose and the Delicious Secretby Suzanne Williams Fiona Sansom
Everyone is delighted when delicious treats start appearing overnight at Mistress Lily's Fairy School! Everyone except Cook, that is-he doesn't want someone else to do his job. Can Rose find out what's going on and restore harmony to the Cloverleaf Cottage kitchen?
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Marigold's new pet firefly, Flash, is the perfect companion. He's sweet and affectionate and just the right size to cuddle with. All the students at Mistress Lily's Fairy School soon grow to love him. But when Flash goes missing, Marigold is heartbroken! Will she ever find him?
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Okay so I know that I'm a little late with the postings and all so let's get down to business shall we. Sunday night was the Extreme Rules PPV (aka One Night Stand). I thought this PPV was going to be dissapointing but man was I wrong.
The first match I want to talk about is that of Chris Jericho and Rey Mysterio. These two guys work great together and on Sunday they were awesome. It's also good to see a heel that I enjoy win. Chris Jericho is a great bad guy and Rey has been getting a little stale. I mean name the last time he won a match without using the 619, you would think after all those matches people would get wise to his act but noooo. Well until Sunday when Chris caught Rey in the middle of the 619. Which was for me just sweet to see. I was kind of shocked about Chris winning because it makes me feel as though now that he has the Intercontinental belt he won't be a huge contender for the World Heavy Weight belt. That and it seemed to me that he didn't need the Intercontinental belt, it felt as though Rey might have though. Oh well, maybe Chris will be the third person in history to hold both a major title and the intercontinental title.
The second match I wanted to talk about is Batista vs. Randy Orton. This was a quick match somewhere between 7 and 12 minutes give or take. Which wasn't bad because for a while now I thought these guys were boring. So to see this go pretty quickly isn't a bad thing. The only thing about this match I didn't like is the way it was hyped. "Randy Orton is going to have to face a caged animal" uhhh... correct me if I'm wrong but doesn't Batista lose cage matches quite regulary. I mean off the top of my head I remember Edge beating him in a cage match so honestly Batista in a cage isn't horrifying at all. Back to this match though, I can't get into cage matches anymore because the brutality of it all has totally left. So all this match turned out to be is a regular match with a fence around it. Oh well at least it was a quickie.
The third and final match of Sunday night that I want to talk about is Jeff Hardy vs. Edge. For those of you who don't know Jeff Hardy's contract to WWE was going to run out so when he openly said that he was going to re up with WWE it was a given that he would win the title. Because lately Edge has been needing a break. So going into this match I knew exactly what the outcome was going to be, and I was exactly right. However I didn't know what was about to happen and that was CM Punk cashing in his MITB briefcase and pinning Hardy for the World Heavy Weight title. My mouth hit the floor. I honestly was dumbfounded because I thought that wouldn't happen unless Edge won, but here Jeff won and bam Jeff lost. Don't get me wrong I'm not unhappy with this. I'm a huge CM Punk fan. But this makes me wonder if he's now going to be pushed as a heel on Smackdown. Because he went and pinned the biggest face on the show. Maybe there setting it up to where Jericho becomes a face again and CM Punk takes his place as a heel. Which isn't a bad idea but it will take a while to get Jericho back to being a face because he's done some very heelish things in the last year. Oh well time will tell I guess see you later for part two (unless I don't get back here in enough time before Smackdown)


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In two weeks, Michigan State had plunged from No. 6 in the country to No. 11 and then to No. 20 with three straight shutout losses entering Thursday's quarterfinal match at home against Penn State in the Big Ten men's tournament.
The Spartans still couldn't score but advanced thanks to a 4-3 win in a shootout after their game ended 0-0.
Michigan State goalkeeper Chris Austin stopped the last two attempts from Stephen Reihner and Daniel Martini to win the game.
"We played well, brought it together and really stepped up, hustled and had a lot of confidence throughout the game," Austin said.
The other two ranked Big Ten teams in action Thursday in East Lansing both won.
No. 16 Northwestern used two David Roth goals to defeat Wisconsin, 3-1, and No. 18 Ohio State beat Michigan, 1-0, on Xavier Balc's first-half volley.
Northwestern 3 Wisconsin 1
NU-Roth 2
UW-Miller 32
NU-Roth (Blades) 52
NU-Blades (Bellizzi) 66
Ohio State 1 Michigan 0
OS-Balc 15.
Michigan State 0 Penn State 0
(Michigan State wins 4-3 on penalties.)


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Goulet Silicone Grease
Silicone grease is used for sealing the threads for eyedropper conversions, or for greasing your piston seal pens. One 1/8 oz container of clear 100% silicone grease.
Technical Specs
Usually Ships in 1 to 2 Business Days
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Goulet Silicone Grease is rated out of 5 by 329.
Rated 5 out of 5 by Nancy Hartzog from Keeps Ink Where It Should Be After watching a video on how to convert an appropriate fountain pen to an eye dropper, I decided this was something I wanted to do. Since the two Preppy pens I ordered for this purpose still have cartridge ink to be used up first, I decided to turn one of my Kaweco Classic pens into an eye dropper. I used the silicone grease on the threads and the seal has worked wonderfully well. Not even the tiniest smidgen of ink leaks out. Silicone grease is indispensable in keeping the ink where it should be. Although the container is small, since only the smallest amount is needed, I figure I have enough on hand to make literally hundred of eye droppers if I so desire (which, by the way, I don't).
Date published: 2014-10-20
Rated 5 out of 5 by Mick from A happy Aussie Earlier this month I bought a Noodlers Ahab, some Noodlers ink (one of which came with a free Noodlers Charlie) and some Goulet Nibs. I was lucky enough to have my brother in law holidaying in the USA as the shipping over here makes dealing with you guys prohibitive and Noodlers products are hard to come by. The 1.1mm stub now sits on my Jinhao 159 (white pen with black nib looks so hot) I love it. I also really like the Charlie. I can't put it down. The service and advice I received from Ross on the Chat line was first class and the packaging just amazing. I am one happy Aussie. Thanks mate. Mick
Date published: 2016-07-29
Rated 5 out of 5 by Melody Polson from Eye-dropper is the way to go for journals As an English teacher of middle and high school students, one of the hardest things to teach today is hand writing. Composition may be fast on the computer... but it is dependent on too many things- power, a device, and a place to use it that is safe... journaling, instead, is a method of students practicing the capture of thought... And since, in my state, handwriting isn't given much time anymore, getting students to journal is pulling teeth. However- unique writing implements intrigue many... and an eye-dropper fill permits me to pass about a pen for experimentation all day long. The Goulet Silicone Grease keeps the pens from making a mess. I am thrilled with the potential of expanding my 'demonstrators' to incorporate different nibs, different ink colors or types to entice young writers to keep pens moving on pages all their lives.
Date published: 2014-10-20
Rated 4 out of 5 by Dan Esposito from It's Plenty I had tried to find some locally, but most of it is white and rather dense, almost caulk-like in consistency. The GPC grease is super pure and very silky, more like vasoline in consistency. I was also worried that it was a rather small quantity. The amount of grease you actually use, per pen, is incredibly small. The container they provide will easily keep 20 daily use pens slick and clean for well over a year.
Date published: 2014-10-20
Rated 5 out of 5 by Wally Root from Pretty slick grease I use this silicone grease to increase the suction of my fountain pen converters by disassembling the converter housing and applying a minute amount of silicone grease to the rubber gasket at the end of the plunger. That increases the pressure, stopping air leakage, as I fill the converter with ink. For a couple of bucks, I'll have enough silicone grease to last me many years. It's good to have in the toolbox.
Date published: 2014-10-20
Rated 5 out of 5 by Aaron V from Definitely worth it I tried to get my own silicone grease in a hobby store before and just couldn't find this exact same type. There are many types of silicone grease used for all kinds of things and you don't want to risk getting the wrong one. This is a must own for eyedropper conversions and this is the most convenient way to get it. It works perfectly as is an ample amount that will probably last me years.
Date published: 2014-10-20
Rated 5 out of 5 by DMac from Exactly what it says on the tin It's simply good-quality silicone grease. Used it on an older piston-filler of mine and it works like a dream now. Also used a near-microscopic amount of it to grease the pistons on a couple sticky, hard-to-turn cartridge-converters and that fixed them up great. Saved me from having to buy new ones.
Date published: 2014-10-20
Rated 4 out of 5 by Frank Bruno from Great Grease! If you're into serious pen maintenance, or perhaps have a pen that can handle the eyedropper alternative, then the Goulet Grease is a must have.. works great and is the right size for your fountain pen kit (I don't fish but I imagine it's like having a tackle box!). Goulet makes it easy, and, they teach you how to use the stuff most effectively.. an outstanding company!
Date published: 2014-10-20