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Q: I want to hand in my form but I can't find your office! Where
is the Development office?
A: We are in the East Medical Office Building on the ground floor in Suite 564.
Q: I signed up for payroll deduction a few weeks ago…but nothing
has come out of my paycheck yet! Why?
A: If you sign up for payroll deduction, your contributions will start coming out of your paycheck in July and will continue for 1 year until your whole pledge is fulfilled. (That means if you signed up for payroll deduction for last year's 2013 Employee Giving Campaign, you probably still have deductions from last year coming out of your paycheck. These will stop in June of this year. If you re-sign up for the 2014 campaign, your deductions will be spread out from July 2014 – June 2015).
Q: What are some of the projects at Lankenau that need my help?
A: Visit our Gift Designations website for some of Lankenau's most current requests for funding.
Q: Is there an Employee Giving giveaway this year?
A: This year, donors of $2 per pay period ($52 total) or more will automatically receive our Lankenau Medical Center "Give Where You Live" magical mug. If you mailed in your form or signed up online, contact the Development Office to arrange to pick up your gift (or visit the Employee Giving table which will be in the cafeteria throughout the campaign).
Q: Why is it such a big deal that employees want to give back to
A: Our wildly successful Employee Giving Campaign sends a powerful message to the people in our community that those who are closest to our institution, and know it best, realize that Lankenau's mission is something worthy of support. If our own employees choose to support Lankenau with their own charitable gifts, there is perhaps no greater case for support from the patients, families and community members who use Lankenau's services.
Q: If I signed up for payroll deduction last year, will it
rollover and continue this year?
A: NO! You must re-sign up in order to contribute to the 2014 Employee Giving Campaign.
Q: Is this the same as the United Way Campaign?
A: No, they are separate. The United Way raises money for thousands of non-profit organizations worldwide, whereas the Employee Giving Campaign specifically helps fund the programs and services Main Line Health provides to the people in our hospital communities. In other words "our gifts live here!"
Q: How does the "refer a friend" program work?
A: Returning this year! Last year, Lankenau introduced "refer a friend" to help increase participation in the Employee Giving Campaign in a big way. Do you have a friend or colleague who has never participated or perhaps used to contribute, but not anymore? Why don't you refer them to sign up for the Campaign! When a new or lapsed donor contributes, they have the option to give credit to the individual who "referred" them to participate in the Campaign. Anyone who successfully refers new donors will receive special recognition as an Employee Giving Champion and be entered to win a special raffle prize! If you are a new or lapsed donor, be sure to either write the name of the person who referred you on your form, or in the designated box when you sign up online. You will also be entered to win a special raffle prize!
Q: I forgot to include the name of my coworker who referred me to the
Employee Giving Campaign when I made my gift. What now?
A: No problem! Send a quick email to Brittany Thompson with the name.
Q: Why am I still having money taken out of my paycheck for
Employee Giving? - I haven't signed up yet this year!
A: When you sign up for payroll deduction, contributions start coming out of your paycheck on July 1 of that year and continue for an entire year until the pledge is fulfilled. Technically this means that if you signed up for $1 to come out of each paycheck for the 2013 Employee Giving Campaign, those $1 deductions will continue until your last paycheck before June 30, 2014. On July 1, of this year, the new 2014 Employee Giving Campaign deductions will begin.
Q: How much of my dollar actually goes to support the program or
service I selected?
A: When you select a specific fund to support, your gifts are what we call restricted - where you, the donor, have specified your desired use for your contributions. We have an obligation to use all of your funds for their intended purpose, or return them to you if we are not able to fulfill your wishes.
Q: How can I become more involved in Employee Giving?
A: We have an Employee Giving Committee that is made up of employees just like you! If you would like to become more involved in the planning and execution of the Campaign, please email Brittany Thompson.
Q: How can I specify what purpose my contribution goes towards?
A: We want to make sure your gift supports a fund that you care about. Both the paper form and payroll election online give you the option to pick what designation you would like your gift to go towards or to specify "other" funds in the space provided. Visit our Gift Designations website for more information on the services you can support at Lankenau.
Q: If I contribute, will my name appear on a list of donors?
A : Each year, the Lankenau Medical Center Foundation releases an annual report of donors, including a list of the employees who gave during the Employee Giving Campaign. Your name will appear on this list unless you specify that you would like to remain anonymous. For a list of donors to the 2013 Employee Giving Campaign, click here. The entire fiscal year 2013 annual report is available here.
New for 2014: In order to better recognize our employee donors, we will be installing a beautiful Employee Giving Donor Wall in the cafeteria at Lankenau. Each year the wall will be updated to list all the names of the Employees who participated in the campaign. The 2014 Campaign donors will be the first to have their names up on the new wall when it is installed this summer.
Q: If I donate $52 will I receive my free beverage weeks again
this year?
A: Yes! We are once again glad to offer employees who give $52 or more to Employee Giving "Seasonal Sips" - 4 months throughout the year to claim five free cups of of coffee, tea, and fountain beverages courtesy of Aramark. We encourage employees to Go Green and use their own mug during Seasonal Sips. Eligible employees will receive a coupon for the five free beverages before each Seasonal Sips month (July, October, January and April).
Q: I gave more than $52 through PeopleSoft - how do I collect my
giveaway bag and free beverages?
A: You can stop by the Development Office to pick up your Employee Giving magical mug - this year's giveaway. Seasonal Sips coupons will be mailed to you in advance of each of the monthly promotions throughout the next year.
Q: Can I give to the Employee Giving Campaign if I work for
Aramark or a non-MLH doctor's office?
A: Yes! Although Aramark and non-MLH employees cannot sign up for payroll deduction, you are more than welcome to contribute with credit card or check using a paper form. Thank you!
Q: Why do you ask for my Social Security number on the paper
A: Payroll requires us to collect your social security number in order to process payroll deduction elections. You can choose to give to Employee Giving through PeopleSoft online if this makes you feel more comfortable. Click here to sign up online. If you gave to Employee Giving through automatic payroll deduction last year, we will not require your social security number this year.
Q: Am I eligible to win any raffle prizes?
A: We have many raffle prizes available to employees who give to a Lankenau fund. Once you hand in your paperwork or sign up online for Employee Giving, you will automatically be entered in each of the subsequent raffles. That means the sooner you get your gift in, the more prizes you are eligible to win! One raffle - the chance to win a premium parking spot for an entire year - has a minimum donation of $100. The full list of raffle prizes can be found here.
Q: When is the last date I can give?
A: This year's campaign ends June 13, 2014. Although the fiscal year doesn't end until June 30, we need to allow time for payroll and our central department to process gifts. Please make your gift to the Employee Giving Campaign by June 13, 2014.
Q: "I am confused by the paper form - what do I need to fill
A: Read our helpful guide to filling out the 2014 Employee Giving Paper Form. Hopefully this will help.
Do you have a question about Employee Giving? Email Brittany!
© 2016 Main Line Health
Copyright 2011 Main Line Health
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The information provided in this Web site is for informational purposes only. It is not a substitute for medical advice. All medical information presented should be discussed with your healthcare professional. See additional Terms of Use at www.mainlinehealth.org/terms. For more information, call 1.866.CALL.MLH.


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Millions unaware they suffer from high blood pressure
JOHNSON CITY, Tenn. - "I found out kind of by accident because my wife is a nurse," said Chris Terry about his problem with high blood pressure.
Millions of Americans struggle with high blood pressure in the United States and they do not even know they have it. It is the cause of nearly 1,000 deaths per day and it is hitting closer to home than some may think.
"It's very common in this area and that is probably related to the lifestyle," said Dr. Marc Mayhew.
The lifestyle, Dr. Mayhew says, is directly related to fried foods, but eating unhealthy and not exercising are only two ways to develop high blood pressure; a third way could be involuntary. "Things we cannot control are family history that could propose someone to high blood pressure," said Dr. Mayhew.
We learned that the first time most people hear about it is when they go to the doctor's office for a routine checkup.
Even if you do not have high blood pressure, you should still take precautions and Dr. Mayhew says that exercise is the key. "Set aside anywhere from 20 to 60 minutes a day to go for a nice brisk walk," he advised.
Terry has been dealing with his high blood pressure for four years and told us there are a few things everyone needs to be aware of. "Eat right, get exercise and take your medication. That's probably the most important thing," said Terry.
We also learned that drinking a glass of wine can also help, but Dr. Mayhew says to not over do it because too much alcohol can actually raise your blood pressure.
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subset: commoncrawl


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Call him the new "King of Clubs": On his last night in Las Vegas, where he had played host to a weekend pool party, Jon Gosselin decided to hit up not one, but two nightclubs.
After dinner at Mirage's Stack Monday night, the tabloid target and his crew headed to Jet Nightclub at Midnight, where he spent most of the evening chain-smoking and texting.
Drinking Skyy Vodka, Gosselin largely ignored several women vying for his attention – instead focusing on his friends and his phone. He did take his eyes off his mobile for a moment, however, to dance on the sofa when DJ Class's "I'm The Ish" came on.
At 1 a.m., Gosselin headed to XS Nightclub. Sitting at a table near the dance floor, Gosselin again stuck to texting, paying little if no attention to the women dancing just a few feet from him.
Switching to Grey Goose vodka, the father of eight went mostly unrecognized while wearing a collared shirt and jeans before leaving the club at 3 a.m.
Gosselin was expected to leave Vegas Tuesday morning.
Jon Gosselin Hits the Vegas Clubs
Ethan Miller/Getty


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Contact Information
Office of Management and Budget
301 County Office Building
39 W. Main St.
Rochester, NY 14614
Phone: 585 753-1260
Fax: 585 753-1254
301 County Office Building
39 W. Main St.
Rochester, NY 14614
Phone: 585 753-1260
Fax: 585 753-1254
The Monroe County Office of Management and Budget prepares, publishes, and administers the annual County Budget. It is primarily charged with monitoring expenditures and revenues and conducting analyses of County operations for the purpose of improving efficiency and effectiveness. As part of the annual Budget development process, the Office prepares multi-year fiscal forecasts, analyzes the effect of the New York State Budget on the Monroe County Budget, prepares financial information and analyses for presentation to credit rating agencies, reviews recommendations to the County Legislature, and ensures consistency with County Executive Maggie Brooks' commitment to providing the best possible service at the lowest possible cost for local taxpayers.
Maintaining a steadfast commitment to protect local taxpayers, County Executive Maggie Brooks presented her proposed Budget for 2015. The County Executive's 2015 Operating Budget, a 0.4% increase over 2014, includes no property tax increase for the eleventh consecutive year, holds spending below inflation, and cuts the County's mandate-fueled structural deficit by over 16%, all while responsibly funding quality-of-life services.
"Monroe County's 2015 budget stands as a shining example of just how much a government can do when it strives to live within its means while enhancing the lives of the people it serves," said Brooks. "This budget maintains my steadfast commitment to protect local taxpayers by stabilizing property taxes for the eleventh straight year, holding spending below the rate of inflation, significantly cutting a mandate-fueled structural deficit, and responsibly funding the vital services that contribute to our community's world-class quality of life."
A Legacy of Tax Stability
For an unprecedented eleventh consecutive year, Brooks has honored her commitment to local taxpayers by proposing a stable property tax rate. The 2015 Budget preserves the property tax cut that Brooks delivered in 2008, and maintained over the last six years in the midst of a deepening national economic recession, holding the rate flat at $8.99 per $1,000 of assessed value. As a result, the property tax rate is lower now than when Brooks took office and she becomes the first Executive in County history to hold the rate flat for nine straight years. The Budget also complies with the New York State Property Tax Cap.
"Protecting local taxpayers has been the guiding principle in every budget I have presented since taking office as County Executive," said Brooks. "Because property tax stability is a commitment that I will not compromise on, I am proud that our 2015 Budget provides a eleventh consecutive year with a stable property tax rate for homeowners in our community."
Spending Held Below Inflation; Complies with Taxpayer Protection Act
A testament to Brooks' continued commitment to fiscal responsibility, the 2015 Budget holds non-mandated spending – or the spending that the County can control on a local level – below the rate of inflation.
The Consumer Price Index (CPI), an indicator used to determine changes in the rate of inflation, currently stands at 1.7%. The 2015 Budget succeeds in holding non-mandated spending to an increase of only 1.5%, putting it in full compliance with the Taxpayer Protection Act. The Act, which was proposed by Brooks and passed by the County Legislature in 2007, serves as a first-of-its-kind local property tax cap by requiring annual increases in discretionary spending to be no greater than the rate of inflation.
A Commitment to Fiscal Responsibility – Past, Present, & Future
As a direct result of years of forward thinking financial planning, and with an eye on protecting taxpayers in the future, Brooks' 2015 Budget cuts the County's mandate-fueled structural deficit by more than 16% for the 2016 and 2017 budget forecasts.
As costs mandated by New York State and the Federal government have continued to outpace the growth of local revenues, most New York counties face year-over-year deficits. Many have been forced to adopt drastic solutions, including double digit property tax rate hikes, slashed funding for public safety services, and massive layoffs.
Brooks' 2015 Budget not only avoids such drastic solutions to achieve balanced spending, it draws upon years of fiscal restraint to secure an unprecedented cut to the County's annual structural deficit. The deficit reduction, projected at $9.5 million, will enable the County to do even more to protect local taxpayers in the future.
"Our 2015 Budget achieves the unprecedented by significantly reducing the County's mandate-fueled structural deficit," said Brooks. "As a result of forward thinking financial planning and fiscally responsible balanced budgets, the County can simultaneously protect taxpayers and maintain vital services now, while cutting the deficit for the years to come."
Bridging the Gap to a Balanced 2015 Budget
To address the County's mandate-fueled structural resource gap for the coming year, the 2015 Budget calls for the sale of some property tax liens, personnel reductions, departmental efficiencies, and minor revenue enhancements, which enabled Monroe County to successfully close a $25 million structural resource gap for 2015.
A Top-Down Dedication to Fiscal Responsibility
For budget year 2015, Monroe County again set aggressive internal budget targets to control costs and do more with less. Embracing Brooks' commitment to fiscal discipline, Monroe County's internal departments, offices, and divisions worked to identify and secure $6.0 million in operational efficiencies for the coming year.
The savings were achieved through a combination of innovative cost-avoidance measures, including the effective management of vacancies for funded positions, workforce health insurance savings, strict oversight of capital expenses and debt service, and implementation of general efficiencies across county government.
No Reductions to Quality-of-Life Services
Under Brooks' leadership, Monroe County has been recognized as one of the top ten places in the world poised for greatness and one of the best places in the country to raise a family, among other accolades. The 2015 Monroe County Budget responsibly maintains the services that are vital to maintaining our community's high quality of life, including in the areas of parks, public safety, and transportation infrastructure.
Leading the Fight for Mandate Reform
The single largest portion of Monroe County's 2015 Budget is mandated spending, which accounts for a staggering 85% of the County's total spending for the coming year.
"When the State requires counties to deliver services, but refuses to provide funding to cover those services, taxpayers pay the price," said Brooks. "I am asking all of my colleagues in the County Legislature to raise their voices and join me in the fight for real mandate reform, so we can finally move from a goal of tax stability to a reality of tax relief for local families."
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"Our goose is cooked," writes a mortgage trader, imagining a conversation at the trading desk of a pure GSE mREIT like Annaly (NLY). With MBS prices bid to all-time highs (thank you Fed) and refinances on the way up, mREITs face an ugly combination of lower yields and higher prepays. One solution: Unload their MBS at these high prices - tell the staff to take a long vacation - and wait for Bernanke to exit.
"Our goose is cooked," writes a mortgage trader, imagining a conversation at the trading desk of...
From other sites
Video at CNBC.com (Jun 10, 2016)
Video at CNBC.com (Jul 15, 2015)
at CNBC.com (Dec 17, 2014)
at CNBC.com (Sep 29, 2014)
at CNBC.com (Jul 10, 2014)
Comments (68)
It wouldn't be the first time MREITs have had a major pullback. I have some quibbles with the imagined conversation. I doubt that anyone in the industry is blaming the pullback on Bernanke; Fed policies have provided a bonanza for them. And CIM is far from being a disaster: with low leverage and rising book value, it could be the biggest winner of all, once the accounting is straightened out.
This is very true. I believe most who could refinance have done so already and are not willing to incur additional closing costs,etc to shave 50 points off their mortgage. Those who have not, may still not be able to even under HARP if they stopped making payments. Again, panic selling becoming a self-fulfilled prophesy.
So the long awaited Sept Correction is underway and the Negative Nellies are out and about in force. The rate of return is still better than the blue chips and any of the MMs, CDs and US Treasuries. So Panic if you must, Those with Cash On Hand will profit.
larrysocie........."wr... by Karl Rove....."
Robin Heiderscheit, contributorComments (3300) | + Follow Following - Unfollow
Panic always means opportunity. Do your own research and don't follow the crowd. I have been invested in AGNC, MTGE, CYS, and ANH at various times over the last 30 months. Two weeks ago I sold my pure play MBS agency mREITs for hybrid mREITs. if anyone thinks that there is a better way to obtain a higher yield please let us know. If one is in close to BVPS enjoy the ride.
This imaginary thread sucks! Try to induce panic selling more for no apparent reason right as an institution drops all of its mreit holdings. Maybe you'll take out some stop losses before the price gets bid back up? Some mreits are doing superb in this environment. AMTG just raised their dividend for example.
Actually, it's starting to look like the Fed has basically become another agency mREIT! After all, they buy agency mortgages, and to fund this they sometimes sell short term notes (just like NLY and AGNC do with repo's), or they "print money" (technically they give the seller a credit in their fed account), which is basically borrowing at 0%.
Federal Reserve Chairmen along with their 'policies' have been major problem causers to my portfolio since Volker left. After retiring, Greenspan admitted discovering that he had not grasped the complexities of our economy as it related to his policies, and Bernanke will surely have the same realization after he has applied all of his "Rube Goldberg' mechanizations. Gives me frequent heartburn! And politicians are worse because they have abdicated their responsibilities by adding mandates to the Fed's plate rather than stepping up to the plate.
It may be worthwhile to recall the Keynsian "beauty contest": what you think a stock is going to do tomorrow isn't important, what is important is what you think the crowd thinks a stock is going to do tomorrow. I sold all my AGNC at $35 the day after the record date for the latest dividend, and I'm waiting for the crowd to finish trading it down (due to the well-publicized collapse of the spread and the expected reduction in dividends) and then I'll try to buy it back when the crowd figures out that a 10 - 11% return is still better than they can get anywhere else, and begins bidding it back up again. I see AGNC today postponed its earnings announcement by a week from 10/22 to 10/29: I expect that the Q3 financials will demonstrate a sustainable (if reduced) dividend, and that the company will lower the dividend to that level in December.
I respect your discipline. I failed to sell when I was at the top and knew I should. I'm in AMTG. Last BV $19.65 current almost certainly higher. Target price $23.50 or so. I'm disappointed I lost the cap gain but confident this sell-off is short lived especially for a stock as fundimentally sound as AMTG. I've done very well with it since April and have been in and out several times.
Chat that depends on your costs. CIM still pays a decent dividend. Where is your Cost + Div break even point? I own some Shares of CIM in two different portfolios, in one I bought low and have a clear profit plus dividends. in the other the current PPS is still lagging my cost, but I am well ahead when dividends are taken into account. So I am holding onto both positions at this time. I hope that the current acct'g mess will be straightened out and provide a boost to the PPS in the coming month or Dec. if not I may sell off and await the announcements from CIM management.
I suggest if you want to play in the MBS game get into quality names holding agency backed securities. My favorite is NLY although I've been out of it for a year now because I didn't like the Refi impact on future earnings. Their earnings estimate is now down 29% Y/Y. I also like TWO, & AGNC & have owned both in the past. I believe they are now too expensive.
All said, I suggest get into quality names & diversify. And if you are going to invest here, learn what you are investing in. These securities live & die by the spread in interest rates, & are highly sensitive to interest rates.
AGNC, ARR, or the rest aren't collapsing. Rates remain pretty much unchanged and the profits are still rolling into MREITS. And since MREITS have to pay out 90% of their profits in dividends, the only thing that will impact those dividends will be Macro Economic changes in the either the Bond Market, Fed Funds Rates, or some massive wave of homeowners refi'ing their homes. Which I see is very unlikely because (a) the savings on a few basis points is negated by the closing cost fees, (b) many of those who want to refi have homes which are underwater or flat, and (c) bank lending requirements are so tight that only a fraction of homeowners can even qualify to refi at super low rates.
People are way over reacting to the FED QE3, basically playing it safe till this QE3 makes a drop in the bucket, MBS Agency trades 400 billion a day, the FEDS 40billion dollar buying program is monthly, not even weekly, this is more of a psychological effect to help the market recover, and help some very small amount of sector to refinance into a better position. Bring on the QE3, I will be long silver, and mREIT and Hybrid REIT, no buddy is bigger than the market, and people in America are always going get a Mortgage to buy a overpriced home, (especially since America is being de industrialized) the MBS industry is only going to get bigger and bigger.
Lets also not forget the demographics in America. 70/million baby boomers are turning Age 65 at the rate of 10,000/per day. And that rate will be sustained until 2031.
AlbyVA..............."... with their massive nest eggs"
As a holder of 100% REITs in my portfolio since 2007, I have never failed to outperform DJ, NASDAQ, and S&P. The market rises and falls but the REITs always come back. I have tried selling and buying back but it has never worked out. You can get lucky every now and then but not often. I have dumped (NLY and CIM) and reduced holdings in AGNC to buy more of others (I hold 17 REITs) to insure I have no more than 10% in one stock. I believe we are going to see an average dividend of 12% in 2013. AGNC is sure to drop to $1.00 or so. Don't worry about the value of the shares. The dividends will flow. If the stock drops in price, use the dividends to buy more. With REIT's, it is not about share price but how many shares you own. If you are going to sell, wait until after the election. No telling how the market will react to the outcome.
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text:
John D. Nixon Collection of Paintings: John Elwood Bundy, Paintings
A retrospective exhibition, most on loan from Mr. John Nixon of Centerville, a close friend of the artists. The paintings are largely landscapes of the environs around Richmond, IN . John Elwood Bundy was born in Guildford County, NC, May 1, 1853. When he was 5, his parents moved to Indiana. Bundy studied for a short time in Indianapolis and New York. Then returned to Indiana where he taught drawing and painting for eight years at Earlham College.


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Daily Journal
TUPELO – The Spain House's history will come alive next weekend.
Members of the Tupelo Historic Preservation Society will host a fundraiser to raise money to apply for a grant that will pay for a new roof and a wraparound porch on the house, which now sits on Church Street and dates back to the early 1900s.
The food and music will recall those years, said Doyce Deas, who's heading up the fundraiser.
"The menu is Southern fare: fried chicken, deviled eggs, skillet biscuits, potato salad, fried pies," she said.
A pianist and fiddle player will play old-time music.
The fundraiser is 4-6 p.m. Sept. 14 on the house's grounds, and the house will be open for folks to see it as it is now.
"The fundraiser is in the daytime because there's no electricity," Deas said. "The inside needs a lot of work, but it's not in total disrepair."
The preservation society hopes to turn the Spain House, one of the last "wedding cake homes" that lined Main Street, into a common ground for area historical societies and geneaological groups.
The society needs to raise $40,000 to apply for the grant, and only about $5,000 has been committed.
Shingles and columns will also be for sale to help raise the money needed.
"That's the urgency of what we're trying to do," Deas said. "We're also taking donations."
Music & More
WHAT: Spain House fundraiser
WHEN: 4-6 p.m. Sept. 14
WHERE: Spain House, Tupelo
COST: $25, includes food, with beer and wine for sale


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by Jules Witcover
This first novel by a Washington political columnist is of course about a Washington columnist who is fending off a crooked ousted President who wants the office again. It is a surprisingly bad novel, humorless, obvious in its plotting and constantly slowed by explanations about how newsmen work, tedious stuff to sophisticated Watergate-era readers. Curiously enough, the characters seem not to be modeled on real people. They seem derived from other books, twice removed from life. (Viking, $9.95)
Picks and Pans Review: The Main Chance
updated 07/30/1979 AT 01:00 AM EDT
•originally published 07/30/1979 AT 01:00 AM EDT


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Braided Challah #SundaySupper
Author: Susan Palmer adapted from The Mile End Cookbook by Noah and Rae Bernamoff
I found that this bread tasted better and more "challah-ish" after it sat for a day. While delicious right out of the oven, the crust softens and the inside is more pillowy.
1¼ cups lukewarm water
1 large egg, room temperature
2 large egg yolks, room temperature
1 package (2¼ teaspoons) active dry yeast
1 tablespoon canola oil
¼ cup sugar
4 cups bread flour
1 teaspoon kosher salt
1 additional egg for egg wash
In the bowl of your stand mixer, combine the water, egg, egg yolks, yeast, oil and sugar. Whisk until combined.
Add the flour and salt and using the dough attachment, mix on medium for 3-5 minutes until the dough comes together.
Let the dough rest for 5 minutes and then mix for another 3-5 minutes until the dough is fairly smooth.
On a well floured surface, roll the dough into a ball and place in a lightly greased bowl and covered with plastic wrap. Leave in a warm, draft free area to rest until it has doubled in size - about 2 hours.
Transfer the dough to a floured surface and divide it into 3 even portions. Working with one portion at a time, roll into a 12 inch long rope thats wider in the middle than the ends. Repeat with remaining portions of dough.
To braid the challah:
Set one strip in front of you and the remaining two at a 45 degree angle on each side so they just overlap. Tuck the edges in and then gently lift one of the outer strips, crossing over the middle and place it along the outside of the outer strip.
Next bring that outer strip and cross over the middle, laying it down. Tug on each strip as you braid, continuing all the way down pinching the edges together at the end.
Transfer to a large baking sheet that has been greased with oil. Brush the top of the challah with oil and cover with plastic wrap. Let rest in a draft free, warm area for about 1/12 hours.
When ready to bake, remove the plastic wrap and brush with the beaten egg wash.
Pre-heat your oven to 350 degrees and bake for 25 minutes, rotating half way through. The interior temperature of the challah should read 180 degrees.
Recipe by
The Girl in the Little Red Kitchen
at http://girlinthelittleredkitchen.com/2013/01/braided-challah-sunday-supper/


text:
Megan Greig, PHR
Human Resources
frog design, inc.
1327 Chesapeake Terrace
Sunnyvale, CA 94089
Tel. (1) 408 734 5800
Fax (1) 408 752 1180
Dir. (1) 408 990 5271
Megan.greig at frogdesign.com
http://www.frogdesign.com <http://www.frogdesign.com/>
The information contained in and/or attached to this e-mail is
Confidential and Proprietary Information of frog design Inc. and its
operating companies and subsidiaries. This information is intended only
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Home » Copyrights »
Common Law Copyright on Schindler's Actual List?
Joel Hecker at the New York State Bar Association Entertainment & Sports Law Section writes about a decision issued by the New York County Supreme Court on December 21, 2010 involving the lists prepared by Oskar Schindler on which Steven Spielberg's motion picture Schindler's List was based. As Hecker describes:
Apparently there are three original versions of this list of "essential" workers, created by Schindler, which contain the names of the more than 1,100 Jews he saved. One list, discovered in his suitcase, is at the Yad Vashem Museum in Israel. A second one was left to the plaintiff by Schindler's widow, with the plaintiff claiming common law copyright in it. The third one was kept by his accountant, and then given to the accountant's nephew, who wants to sell it. This copy is nearly identical to the one owned by the plaintiff.
The plaintiff sought an injunction under common law copyright theory in an effort to prohibit the sale of the third list. The court denied the motion on the grounds that the "right to sell" is not a copyright right. True, but the exclusive "right to distribute" is a copyright right, and the sale of copyrighted material would likely constitute a distribution.
But this is really putting the cart before the horse. The threshold question–apparently not addressed by the court–is whether the plaintiff owns any copyright interest in the first place. That is a highly dubious proposition. First, the list was created in Germany in the 1940s. No rights would have come into existence under US copyright laws. Second, assuming application of US law, could the list be considered "original" such that it would be protectable under copyright law? That, too, is doubtful. The list was not a creative work, but a list of Schindler's Jewish employees. And, third, at least two of the three copies of the list have been publicly-owned and exhibited (one in an Israeli museum and another in the State Library of New South Wales, Australia). The list is also available online. These circumstances would almost certainly constitute "publication" and, therefore, have injected the lists into the public domain.
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EVENTS.the past
20/06 22:00 - 20/07 8:00
The biggest party ever!!!
- 12.500 m2 jump area
- 250.000 watt. comp. contr. soundsys.
- amazing light performance
- flying lights
- dance acts
- all kinds of food
- chill out/ cool down area
- 20.000 tickets available (buy your tickets presale by official outlets to avoid forgery's)
- guarded parking area
- you can come and go by train all night long !!!
1992. Hardcore house in its initial stage. Not many clubs were playing this revolutionary kind music. Huge raves with thousands of people were unthinkable. Some vinyl was pressed by some labels. House hadn't been split up yet, it was just "house music". The harder kind of house was released on mellow and club music CD's.
The earliest onofficial party of ID&T was a new years eve '91-'92 party at the youthcentre in the town of Landsmeer named Omshanti. Omshanti was to be closed at the 1st of januari 1992, so it would be a farewell party to the youthcentre. 300 people attended this party on the 31st of december.
The final exam
Still hot from the new years eve party at Omshanti plans were constructed immediatly for a second party. This time things moved up a notch. At the beginnig of 1992 ID&T wanted to give a much bigger party.
This party would change the dance scene in Holland drastically... Before 1992, it was unthinkable that 10.000 people would come in one hall to dance all night long. Duncan Stutteheim : "we thought that 3000 people would attent this party, but to our big supprise 11.000 people showed up. It was the beginning of my live. House changed me and formed me. It has changed a whole generation. A new generation started listen to it. It changed the way people thought and felt. With each other."
Even in 1992, it was hard to get a license for a location. House parties were something that was seen as strange and an unknown phenomenon. And even back in 1992, most exploitants had lots of noise and nuisance complaints of hall neighbours. But because ID&T made good contacts with The Jaarbeurs and The Amsterdam RAI, both gave green light to give a party.
It became the jaarbeurs, because of it central position in Holland. This was the very first house party ever accommodated in the Jaarbeurs.The group of friends who organised the previous new years party needed a name. The initials of the three organisers were taken in order of age: ID&T (Irfan, Duncan & Theo). More then 10 years later, in 2002, ID&T would give a Thunderdome in the RAI, with Thunderdome A Decade.
The theme became "The Final Exam". The purpose of this party was to celebrate the closing of the schoolyear of '91/'92.
To promote the party ID&T went to Hilversum, at a studio of Robin Albers, who had his own national radioshow called "for those who like to groove". Also a lot of flyering was done to promote the party.
Although the promotion went really wel, ID&T got more and more in trouble with costs. Despite of the sitbacks, ID&T was hardheaded and wanted to continue with the party.
With the location, theme and organisation fixed, a program of the line up had to be invented. They would begin not all to hard, with Robin Albers. Then Per took his place beind the wheels of steel. The dj's who were know for spinning harder records like Dano and Buzz Fuzz from Amsterdam would finish the party.
After this party Theo left ID&T.


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The Arkansas Scholarship Lottery is warning Arkansans about what they're calling a scam.
Lottery leaders said a person reported receiving a call that she had won $5 million in a second-chance drawing. According to information from the Arkansas Scholarship Lottery, the caller knew the woman's home address, and instructed her to go to a local store to purchase a pre-paid card called Green Dot MoneyPak to use to pay taxes owed on the prize.
Officials said the caller provided a toll-free number that, when called, mimics the Arkansas Scholarship Lottery phone message.
The Arkansas Scholarship Lottery said it has notified the Consumer Protection Division of the Arkansas Attorney General's Office of this scam.


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As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
Cells expressing high levels of EPHB2 propagate in culture and can be triggered to differentiate into absorptive and secretory cell types. [© krishnacreations - Fotolia.com]
Scientists say they have succeeded in isolating, characterizing, and expanding human colon stem cells (CoSCs) from fresh biopsy samples. The international team, led by Professor Eduard Battle, M.D., at Barcelona's Institute for Research in Biomedicine (IRB), and Toshiro Sato, Ph.D., at University Medical Center Utrecht in The Netherlands, suggest the achievement is, to their knowledge, a world first. The work is reported in Nature Medicine in a paper titled "Isolation and in vitro expansion of human colonic stem cells,"
CoSCs renew the epithelium lining of the large intestine, and changes in these cells are believed to account for the pathophysiology of large-bowel disorders including colorectal cancer, the authors report. Unfortunately, scientists have to date been unable to isolate CoSCs. Drs. Battle et al.'s search for CoSCs in humans was founded on previous work indicating that mouse small intestinal stem cells (ICSs) and cancer stem cells express high amounts of EPHB2.
Building on this, the IRB-led team used an antibody against the EPHB2 extracellular domain to purify EPHB2-positive intestinal epithelial cells from histologically normal fresh tissue biopsied from patients with colorectal cancer or diverticulitis. From these sampless they isolated EpCAM+ crypt epithelial cell populations expressing various levels of surface EPHB2.
Further analysis of these cells showed that those with the lowest levels of surface EPHB2 expressed the highest levels of colonic differentiation markers. In addition, EPHB2-negative cells showed up to a 2,500% reduction in the expression of proliferation genes, "implying that this population was composed of cell cycle-arrested, terminally differentiated cells," they note.
The researcher then subdivided EPHB2-expressing cells on the basis of expression levels of the marker. They found that EPHB2high cells had the longest average telomere length and expressed the highest levels of mouse ISC markers. Expression profiling studies showed that in EPHB2high cells there was a set of 90 genes including LGR5, ASCL2, and EPHB3 that was consistently expressed at higher levels in comparison with EPHB2medium cells.
"From these data, we tentatively concluded that the EPHB2high cell population is largely enriched in CoSCs, whereas EPHB2medium and EPHB2low cells represent transient amplifying cells at different stages of differentiation," the authors state.
Development of a suitable culturing system for the cells was based on recent protocols for maintaining mouse gastrointestinal organoids, which involves reproducing ISC niche signals such as activating the Wnt and Notch pathways and inhibiting bone morphogenetic protein signals. However, Dr. Battle et al. found that this mouse protocol required critical changes.
In particular, the maintenance of human colon crypts was dependent on supplementation with nicotinamide and was significantly boosted by the addition of prostaglandin E2. When human colon crypts were maintained under the new culture conditions, they lost their upper third compartment during the first days of culture, while the bottom regions formed closed spheroids that expanded rapidly through cell proliferation but maintained a central lumen. Spheroids that were dissected and re-embedded in matrigel quickly reformed closed structures that kept growing.
Importantly, when cultured under the same conditions, EPHB2high cells sorted from human colon biospies grew exponentially and gave rise to macroscopic spheroids within 18–21 days. The spheroids could be passaged by disaggregation every week, a regime that allowed EPHB2high to be cultured for long periods (over 4 months) in conditions of exponential growth, the authors write. Significantly, individual cells from these spheroids could be separated and recultured, again generating macroscopic spheroids with no evidence of genomic instability.
Under appropriate culture conditions EPHB2high-derived spheroids could also be triggered to differentiate, a process that was accompanied by upregulation of both the pan-differentiation marker KRT20 and differentiation markers of absorptive and secretory cell lineages as well as silencing of ISC genes. Differentiation was accompanied by marked morphological changes characteristic of absorptive or mucus-secreting cells.
"Notably, upon switching to differentiation medium, all single-cell-derived spheroids analyzed generated a mixed population of absorptive and mucosecreting cells, implying that a substantial proportion of CoSCs stay multipotent," the researchers remark.
"Collectively, these data represent what is to our knowledge the first isolation, characterization, and in vitro expansion of a cell population largely enriched in human CoSCs," they conclude. "The cell culturing protocol described here allows the maintenance of an undifferentiated and multipotent ISC-like phenotype in vitro. Our work represents a substantial step forward toward the use of human CoSCs in regenerative medicine and toward understanding their role in pathology."
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"As a Selma native, I know that the journey I now take as Alabama's first black Congresswoman was made possible by the courage of the freedom fighters, like Rep. John Lewis, who fought for the right to vote on the Edmund Pettus Bridge forty-eight years ago," U.S. Rep. Terri A. Sewell said in a released statement. "It is important that we honor their legacy by preserving the collective stories and experiences of members of Congress who were instrumental in the struggle for civil rights."
The website, the House and Selma: Bridging History and Memory, is the result of a bill co-sponsored by Sewell and U.S. Rep. Martha Roby directing the Office of the House Historian to compile accounts from current and former members of Congress who participated in historic civil rights moments, the Selma to Montgomery marches and annual congressional trips to Alabama, according to releases from the congresswomen's offices.
"This project uses special documents, images and oral history to tell the Selma to Montgomery story from a unique perspective. By preserving this important history we can help future generations, including my children, appreciate the stories of sacrifice from the civil rights struggle and understand the lessons that were learned," Roby said.
Roby and Sewell were joined by House Majority Leader Eric Cantor, R-Virginia, and Lewis, D-Georgia, in commemorating the launch.
"Today, we pay tribute to 600 peaceful, non-violent protesters who had the courage to stand up for human dignity. Just forty-eight years ago, these brave participants in the civil rights movement had to face state-sponsored brutality just to simply register and vote," Lewis said.


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Pinpoint lambing dates by raddling your rams
Published 19/09/2012 | 06:00
The recent good weather and high temperatures proved important on most farms and were invaluable for getting crops harvested, including silage in some cases.
Grass growth has also held up well, with 51kgDM/ha/day in the week to September 11, a bit ahead of what we would expect for this time of year. Our forage rape is also coming along well and received a bag of CAN per acre last Wednesday.
Lamb growth rate is running just under 200g/day and we had just drafted 30 lambs at 45kg liveweight at the time of writing.
Last week also coincided with the return of the agricultural science students to UCD.
This really confirmed the bad weather we have had this summer in two ways.
Firstly, we were fighting with the rain to get onto the hill to look at the sheep and, secondly, there are about twice as many lambs still to be sold as there usually would be when the students come back to Lyons.
Ewes are currently being flushed for mating in mid-October and are progressing as we would like.
The good grass growth is ensuring a good grass supply for the ewes despite there being higher lamb numbers on the farm. Again this year we will be mating all the ewes, following synchronisation, using laproscopic AI.
We use a 12-day sponging procedure, with pregnant mare serum gonadotrophin (PMSG) administered on sponge withdrawal and mating occurring 36 hours later.
Great care needs to be taken by anybody using this system, that the PMSG is administered accurately, as an overdose can greatly increase the birth of large multiples. The ewes will then get two repeat services with the ram.
This ram will be raddled (with different colours for each service) to not only record which ewes repeat, but also to indicate the time of lambing.
I think this simple and cheap technique is incredibly useful and even more so in flocks which are not synchronised.
Frequently changing the colour of the raddle from light to dark, will allow farmers to estimate lambing date with a good degree of accuracy and, most importantly, plan the concentrate feeding programme accordingly.
This will lead to cost savings during the expensive pre-lambing feeding period. There are many options available for raddling rams, including harnesses and crayons.
What we have used at Lyons and on my home farm, are raddle powders mixed with oil and rubbed on the chest of the ram.
This is cheap and simple and works very well. Care should be taken when using harnesses.
The harness must be correctly fitted so as not to cause discomfort, irritation or restrict the mobility of the ram.
Practically all of our indoor fed lambs have been slaughtered at this stage, with just 5pc remaining. These will go to the factory in the next week.
These lambs have eaten on average 110kg of concentrates to slaughter, so there is a significant cost associated with the system.
On the other side of the equation there is no requirement for parasite control or cobalt dosing (contained in the concentrate) with these lambs and there has been a complete absence of lameness.
The animals were housed on timber slats. There are two main health concerns with this system, urinary calculi and acidosis.
We did not have an incidence of either this year. Both can largely be avoided through correct dietary formulation and correct feeding management.
Salt levels, magnesium levels and ammonium chloride all have a role to play in preventing urinary calculi, while ensuring a constant concentrate supply, gradual acclimatisation to the diet and the inclusion of slowly fermentable carbohydrates will all help to minimise the risk of acidosis.
Having spoken to some farmers with prolific flocks, they have followed similar systems this year, with their triplet lambs.
One lamb from each set of triplets was removed from the ewe at 24 hours of age, artificially reared to six weeks and fed on all concentrates until slaughter. Straw bedding would also be used in many instances and lambs frequently consume a portion of the bedding offered.
Dr Tommy Boland is a lecturer in sheep production and ruminant nutrition at UCD's research farm at Lyons, Newcastle, Co Dublin
Indo Farming


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DuBoistown Garden Club to hold meeting
The DuBoistown Garden Club will present "Clean Water Resources" by Dr. Melvin Zimmerman, Lycoming College professor, at 7 p.m. Thursday at St. Lawrence Roman Catholic Church hall, 800 W. Central Ave., South Williamsport.
Hostesses will be co-chairwomen Lisa Bock and Patricia Kaczmarek.
Committee members include Georgie Bower, Rita Bower, Tanga Brown, Diane Cramer, Linda Kopsciansky, Carol LaRue, Susan Mahoney and Gretchen Mangiardi.
Williamsport Herb Guild to host meeting
The Williamsport Herb Guild will meet at 7 p.m. Aug. 18, at Covenant-Central Presbyterian Church, 807 W. Fourth St.
Yvonne Morris will present "Plant Based Healing." The meeting is open to the public.
Mountain Laurel Quilt Guild to hold meeting
TIOGA - The August meeting of the Mountain Laurel Quilt Guild and the annual guild picnic will be held at 6 p.m. on Aug. 18, at the Lakeside Shelter at Ives Run Recreation Area.
Family members and guests are welcome.
Guild members are asked to bring a dish to pass and their own table service.
Following the meal a short business meeting and a show and tell of members' recent quilted projects will be held.
All meetings are open to the public.
For more information, visit mountainlaurelquiltguild.org or call Angie at 570-724-6372.
Mock group interview to be held
A mock group interview will be conducted by a representative from the Susquehanna Health System at 9:30 a.m. Aug. 19, at the Lycoming County CareerLink, 329 Pine St. The workshop is free, but seating is limited. To register or for more information, call 570-601-5465. Auxiliary aids and services are available on request to individuals with disabilities.
Garden Club to hold annual picnic
The McEwensville Garden Club's annual picnic will be held at 6 p.m. Aug. 19, at the home of Sandy and Ron Hendricks. A steam cook is being prepared and beverages and a dessert will be provided.
The event is only open for members and their guests.
Reservations are required with a fee. Attendees should bring a chair and a trash-to-treasure item, that will be judged at the picnic.
Food co-op to hold meeting
HUGHESVILLE - A local food co-op informational community meeting will be held from 6:30 to 9 p.m. Aug. 19, at the Hughesville Public Library Community room, 146 S. Fifth St. For more information, contact Pyhllis Dufrene at 570-515-0073 or email letsbui email@example.com.


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Admission to the Mark Twain House is by guided tour only. Ticket prices include the tour of the house and admission to the museum center.
If you know your plans to visit a day or more ahead of time, you can purchase advance tour tickets only using the Buy Your Tickets link above to the right. (Please note that if you are encountering difficulties buying tickets online with a mobile device, please try purchasing on a computer.)
Tours do sell out! Advanced online purchase is recommended. Web sales close several hours before each tour start time. Any remaining tickets are sold at the door first-come first-served.
LIVING HISTORY TOURS with costumed members of the Clemens Family or the serving staff are offered weekly on select days and times. For individual LIVING HISTORY TOUR scheduling and pricing, click here. Several nights throughout the year, we offer GRAVEYARD SHIFT GHOST TOURS and murder-myster CLUE TOURS. Click here for more information on our various tours and ticket links.
Reservations are best for group tours. Discounts are available for groups of 10 or more if booked 14 days in advance.
If you wish to tour both The Mark Twain House and the Harriet Beecher Stowe House, a discount is available. Please click here for more information.
You can become a member, which includes free admission, by clicking here.
Here are the ticket prices for admission to the musuem and a tour of the Mark Twain House:
|Senior Citizens
(ages 65+)
|Under 6
(ages 17-64)
(ages 6-16)
Museum Only*
*Does not include the tour of the Mark Twain House


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HCPS interns develop software prototype
Two Henrico County students have spent their summer internships creating a working prototype of an online application system for students applying to the county's high school specialty centers.
The interns and management of eTelic Inc., the information technology firm that hosted the interns this summer, estimate that an automated system could save students, teachers and administrators as many as 20,000 total hours per year currently spent using the paper-based application process. Printing and paper costs for all also would be substantially reduced.
Jack Palen, a recent Maggie L. Walker Governor's School graduate headed to the University of Michigan, and Shravan Ravishankar, a rising senior at Deep Run High School, developed the online software application during their four-week internship using eTelic's proprietary rapid software application generator called Turanto.
According to Lynne Norris, department chairperson of Deep Run's Center for Information Technology, the real-world experience provided to Palen and Ravishankar in this endeavor will prove invaluable as they transition to college and a job after academics.
"This type of experience allows a student to see beyond school and experience what a business goes through in working to solve a real problem for itself or for a customer," Norris said. "Not many students have an opportunity to do that prior to entering the job market, which everyone knows is getting more competitive each year."
The two students are planning to schedule a presentation to HCPS officials in order to demonstrate the prototype, hoping it will assist county management in determining the scope and value of automating the current system in the future. An online system could replace the paper-based system used by 3,700 students per year as well as hundreds of teachers and administrators who submit transcripts and recommendations for eighth-grade applicants to the county's high school specialty centers.
"Normally this type of software program would take an experienced programmer working full time up to six months to create," said eTelic president Mukul Paithane. "It is remarkable that these two bright students built this complex, data-driven software application in only four weeks, and with minimal programming. Jack and Shravan were able to use their limited time focusing on analyzing a real-world 'business problem' and developing a practical solution to replace a paper-based application process, saving time and money for everyone involved."
Further development of the prototype would allow Henrico County eighth-grade students, teachers and administrators to complete, submit and review various documents online, including the application itself, along with other documents such as transcripts and teacher recommendations. They would be provided with secure access to the system in order to process information needed from them. Specialty Center school admissions officials would then use the system to access all information used to make decisions on which students should be admitted into various magnet schools.
"From my experience in using the current paper system, I know that an automated process would save other students tremendous amounts of time when applying, and the cost-savings for the county should be significant as well," said County Intern Coordinator Robert Stephens.
Reynolds CC to host sculptor Paul DiPasquale
Reynolds Community College will host Richmond sculptor Paul DiPasquale Sept. 28 as he shares his presentation "Art Talk, Why Art Matters" from 6 p.m. to 8 p.m. in the Conference Center Gallery of the Workforce Development and Conference Center on the Parham Road Campus, located at 1651 E. Parham Road in Richmond. This event is free and open to the public. > Read more.
Free children's clothing for those in need
The Children's Clothing Closet at Highland Springs United Methodist Church will be open Saturday, Aug. 27 and Tuesday, Aug. 30 to provide free new or nearly new children's clothing for families in need, prior to the start of the school year. The Clothing Closet will be open from 10 a.m. to noon both days. The church is located at 22 North Holly Avenue. > Read more.
Weekend Top 10
For our Top 10 calendar events this weekend, click here! > Read more.
Henrico to offer four home maintenance workshops
Glen Allen Day in photos
No one injured in Eastern Henrico shed fire
Business in brief
Tuckahoe meeting Sept. 28 to detail bond referendum projects
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Sep. 15, 2016Click here to read the print edition.
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Deadline nears for 'Henrico Live' ticket purchase
CAT Theatre announces cast for October show
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Obituary – Mildred Terrell Tate
Obituary – Stephen Embry Esbach
Obituary – Harry Strachan Hobson
- More Obituaries
Reynolds CC to host sculptor Paul DiPasquale
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Local choral group seeks volunteers
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Storm woes for e-junkies
'Good old days' were good – for some
Of character and parenting
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RIR to admit children 12 and younger free next year
Henrico teams win district, state championships
Varina HS to host Basketball Skill Development Academy June 20-23
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LAST LAUGH: Eric McCormack, Debra Messing, Sean Hayes and Megan Mullally will be getting much heftier paychecks on NBC's "Will & Grace," said the Hollywood Reporter. Effective immediately, McCormack and Messing will be receiving $250,000-$275,000 per episode, with Mullally and Hayes getting only slightly less than that. By the seventh season, McCormack and Messing should be pocketing about $400,000 per episode. All four stars are also tied into syndication rights.
BLOOM EULOGIZED: Thousands of mourners turned out Wednesday for a memorial service at New York's St. Patrick's Cathedral for NBC News correspondent David Bloom, who died while covering the war in Iraq. Bloom, 39, the weekend anchor of "Today" and a former White House correspondent, died of an apparent blood clot April 6 while embedded with a military unit in Iraq. "David was the Ernie Pyle of his generation," said NBC anchor Tom Brokaw, 63, comparing his colleague to the legendary newspaperman who covered World War II, and remembering Bloom's "boyish enthusiasm."
CHICKS CHAFED: The Dixie Chicks apparently still remain political hot potatoes. Singer Vince Gill -- who initially rose to the defense of Chicks lead singer Natalie Maines, 28, after she famously said "we're ashamed the President of the United States is from Texas" -- back-peddled. "It's pretty imperative that I communicate that I held the completely opposite view of Natalie Maines," Gill, 46, told the Tennessean newspaper. "The troops and the president don't have a bigger supporter than me."
CARREY CRAZED: Jim Carrey got slimed and feathered. Britney Spears and Justin Timberlake put on brave faces and laughed together -- though clearly kept their distance. And Jennifer Love Hewitt and Jackie Chan were honored for what they do best (kick butt) at the 16th annual Nickelodeon Kids' Choice Awards. After his dousing, Carrey, grabbed the slime hose and let event host Rosie O'Donnell have a little green goo herself. "What does it feel like?" Carrey, 41, said backstage afterward, according to USA Today. "It feels like love, man, slimy-gooey love."
MOVIE MADNESS: MTV announced its free-for-all Movie Award nominees Monday, with the winners to be named at a June 6 ceremony. The top contenders: "Lord of the Rings: The Two Towers" and "Spider-Man," which scored eight nominations apiece, including nods for best film. Other nominees in that category are "Barbershop," "The Ring" and "8 Mile," whose star, Eminem, is also in the running for best actor. Other acting nominees: Tobey Maguire ("Spider-Man"), Vin Diesel ("XXX"), Leonardo DiCaprio ("Catch Me If You Can") and Viggo Mortensen ("The Two Towers"). Among the women: Kirsten Dunst ("Spider-Man"), Reese Witherspoon ("Sweet Home Alabama"), Halle Berry ("Die Another Day"), Kate Hudson ("How To Lose a Guy In 10 Days") and Queen Latifah ("Chicago").
WEEK IN REVIEW: Stars Show 'Will' Power


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NSCLC is "Major Battlefield" as Merck,...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
"Developing approaches to repair tissue damage is one of the areas of greatest unmet need in multiple sclerosis," says Jeffrey A. Cohen, M.D., professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Dr. Cohen and his colleagues are focusing on developing therapeutic strategies for multiple sclerosis by taking advantage of mesenchymal stem cells, which offer multiple advantages, including the existence of established experimental approaches to isolate and expand them in culture, but their use is also accompanied by certain challenges. "There is a long list of technical issues that need to be addressed in every experiment," explains Dr. Cohen.
While the experience with mesenchymal stem cells has been promising in terms of safety, certain concerns exist regarding potential unanticipated effects. "The approach in our program is to start with a very meticulous safety study and subsequently build upon that," says Dr. Cohen. Another challenge stems from the paucity of data tracking the administered cells in humans, despite an abundance of results from animal studies showing that transplanted cells survive and reach their intended locations.
Dr. Cohen and colleagues recently completed the enrollment of 24 participants into a Phase I safety study of autologous mesenchymal stem cells, and no safety concerns were noted. "We plan to proceed with a Phase II study to illustrate the proof of concept for the benefits of this approach, and we also anticipate tracking the administered cells in vivo," says Dr. Cohen.
"We have developed a highly differentiated product with multiple biological activities that lead to its therapeutic effects," says Nick Colangelo, president and CEO of Aastrom Biosciences. Colangelo's firm has developed an approach that is characterized by several distinguishing features. The proprietary automated system that expands (up to 300 times) key cell types collected from a patient's bone marrow, and the administration of the expanded cells back to the same patient, removing the risk of rejection and eliminating the need for immunosuppressive therapy, are some of the aspects that make this approach unique.
An additional hallmark of this product lies in its multicellularity. Among several cell types that are incorporated, the CD90+ mesenchymal stromal cells and the CD14+ alternatively activated macrophages are particularly important, due to several sets of activities that account for their therapeutic effects. These cells secrete anti-inflammatory molecules such as IL-10, enzymes involved in extracellular matrix remodeling, and potent angiogenic factors such as VEGF.
The activities of these cytokines and growth factors are complemented by cell-dependent activities, with macrophages, in particular, modulating the immune response by phagocytizing cellular debris and exerting cardioprotective effects that include oxidized LDL uptake and cholesterol efflux.
"It is this combination of secreted factors and direct cell activities that leads to the therapeutic effects that we have seen, which involve resolving inflammation, remodeling damaged tissue, and promoting angiogenesis," Colangelo explains.
One of Aastrom's recent efforts is the development of stem cell-based therapeutic approaches for advanced heart failure that develops as a result of ischemic dilated cardiomyopathy (CM). After completing two Phase IIa open-label studies, investigators at Aastrom initiated a 12-month Phase IIb study in 2012.
"We enrolled our first participants in early April 2013, and treated these patients in the second half of the month," Colangelo says. Ischemic CM represents one of the most frequent forms of heart failure, and with the scarcity of therapeutic options that are currently available, the development of cellular therapies emerges as a lifesaving approach for this patient group.
We unveiled the role of a previously unrecognized pathway that is important for maintaining the stem cell state," says Carla M. Koehler, Ph.D., professor of chemistry and biochemistry at the University of California, Los Angeles. In a chemical screen that proposed to identify inhibitors of the mitochondrial FAD-linked sulfhydryl oxidase Erv1, essential for mitochondrial biogenesis and cell survival, Dr. Koehler and her colleagues identified MitoBloCK-6, a small molecule that selectively inhibits the mitochondrial redox-mediated import of Erv1 substrates.
Despite its ability to inhibit Erv1 and its human homolog ALR in vitro, MitoBloCK-6 did not affect the in vivo growth and function of differentiated cells but, surprisingly, caused apoptosis in pluripotent human embryonic stem cells.
"When we differentiated stem cells they were no longer susceptible, and when we reprogrammed them to the pluripotent state, they again became susceptible to this compound," she says.
MitoBloCK-6 is an attractive option to remove undifferentiated stem cells from differentiated cell populations, and presents multiple advantages over existing protocols. "We are further exploring this compound, and hope that it can be used at a certain time during the differentiation protocol to allow the removal of cells that failed to differentiate, without affecting the ones that became committed to become specific cell types," Dr. Koehler adds.
This finding has an additional, more profound significance that extends beyond the field of stem cell biology, as it underscores the cardinal position that basic research plays in advancing translational research.
"There are so many aspects that we do not understand about the function of many cellular pathways at the basic level, and it is difficult to explore the endpoint without performing and trying to understand the basic research. In this case, we are still trying to understand why mitochondria are important for stem cell survival," Dr. Koehler says.
Basic and translational research in stem cell biology and regenerative medicine are witnessing an exciting time. More than 5,000 clinical trials on stem cell therapies are currently under way globally, promising to revolutionize therapeutic prospects. As our knowledge about differentiation and regeneration is advancing, it is essential to appreciate and capitalize on the interdiscliplinary spirit that has become a defining feature of this vibrant and fascinating field.
"Having for several decades been at the forefront of the biomanufacturing and bioprocessing of recombinant proteins and monoclonal antibodies, we envision cell therapies as the next wave that is coming along in this market space," says Firman Ghouze, Ph.D., director of the cell bioprocessing group at GE Healthcare.
One of the research initiatives at GE Healthcare is directed toward the development of platforms that facilitate the transition toward large-scale applications of such therapies. In the case of cell-based therapies, this involves providing solutions that enable investigators to pursue therapeutic programs in a way that is robust and cost-effective—two important factors to consider, particularly for large clinical trials.
"We are also trying to build on the scalability," adds Dr. Ghouze. Significant efforts are being focused toward developing automated and closed systems, which promise multiple benefits, including increased yield, decreased contamination risks, maximal effective use of the manufacturing space, a reduction in the amount of manual work, and the possibility for high-throughput, parallel processing.
Over the past few years, these have represented some of the key aspects that turned out to be instrumental in the bioprocessing of recombinant proteins. "I can see these considerations becoming important as we develop solutions for cell-based therapies," explains Dr. Ghouze.
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Wednesday, January 02, 2013 8:03 PM
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Dajuan Coleman trying to get a shot offduring Syracuse and Rutgers basketball game in the Dome. The first Big East game for Syracuse University this year. Dick Blume/The Post Standard
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Navigational control post
this wiki
Navigational control posts were stations within a particular area of space which guided and managed vessels through that area.
The Cardassians maintained at least twenty-four navigational posts within their territory. They used their sensors to determine the types of vessels within their territory and decide if they were a threat or not. They were also able to dispatch repair ships to assist disabled vessels.
While these posts were able to scan and communicate within a wide area, the quality of communications degraded with distance from the post. At the extreme edge of scanner range, only audio contact was possible.
Kira Nerys and Miles O'Brien used this to their advantage in 2370 when they infiltrated Cardassian space in a runabout disguised as the Lissepian transport Martuk. Cardassian Navigational Control Post 24 detected their runabout as the Lissepian transport, but the modifications showed up as an engine malfunction that got the attention of the Post. Kira was able to convince the commanding officer that they did not require assistance, and the runabout was able to continue on its mission to rescue Li Nalas from Cardassia IV. (DS9: "The Homecoming")


text:
Top Definition
to dressel someone means you have sex with him/her and he/she is just a fuck. you don't give a shit whats the persons name or what he/she ist doing. The sex is rough so he/she can not take action the next days, this person needs to recover. mostly you make sex with this person and you show her/him something new. You brake their mental walls down. Mostly just using the partner as a thing.
i dresseled her last night, now she knows how to deepthroat, she did not show up in office today. so i did realy dressel her.
от Pathfinder198 19 юни 2010
Trending Now
Can you define these popular missing words?
noun; apt to being tall; considered by some to be the coolest mother fucker ever.
Man, Dressel is the coolest mother fucker ever.
от JED 12 април 2005
A big giant douche. Sometimes slightly felched.
You guys smell vinegar? I bet there's a big squirting dressel around!
от notbone 31 май 2007
one drinks more than occasionally and to the extent of returning intoxicated. Also known as one who may inadvertantly get human waste in odd places such as shower heads. Dressel may be interpreted as #1 or #2. This definition explains #1.
Damn he is fucked up like a dressel.
Dressel has been passed out for hours!
Dressel has been passed out for hours!
от 607B fo sho 13 април 2005


text:
This is a discussion on RE: [squid-users] Increasing Filedescriptors on Linux - WARNING! Your cache isruuning out of filedescriptors - squid ; Which version of squid are you using? If your are using a 2.4 series = from RedHat most likely squid will not be able to go over the 1024 limit = without being patched (I found this out the hard ...
Which version of squid are you using? If your are using a 2.4 series =
from RedHat most likely squid will not be able to go over the 1024 limit =
without being patched (I found this out the hard way). squid 2.5 stable5 =
has the patch. I am not sure when the squid developers put it in. Once =
you get a version of squid that has the patch you need to set your =
ulimit to the max number of file descriptors your want your squid to =
able to use (from the command line) then compile.
Like so:
# ulimit -HSn 8192 (I used 8192)
# ./configure ...
# make=20
# make install
Then do/verify the following:
1. Change the init script so it sets the limit to 8192 (or whatever =
number you pick) before running squid.
2. Verify /proc/sys/fs/file-max is set high enough (mine was by default)
3. Set /etc/security/limits.conf to allow the squid userid to use up to =
8192 file descriptors.
That should do it.
-----Original Message-----
From: Mathew Thomas [mailto:email@example.com]
Sent: Thursday, April 15, 2004 7:52 PM
To: firstname.lastname@example.com
Subject: [squid-users] Increasing Filedescriptors on Linux - WARNING!
Your cache isruuning out of filedescriptors
I am bit confused about increasing the filedescriptors. My two proxy =
server's cache.log is flooded with the error
"WARNING! Your cache is running out of filedescriptors". I could see =
from the Cache Manager that squid is using only
I read the Henrik document at the web site =
I have got few question about increasing the Filedescriptors: Below the =
questions are my current (default) values:
1) Do I need to increase the value in /proc/sys/fs/file-max? Another =
2) How much can I increase the vale for " ulimit -HSn ####" without =
causing any performance degradation?
3) Regarding the step "Edit /usr/include/bits/types.h to define =
__FD_SETSIZE ....". Which value should I put it here -
the value in "cat /proc/sys/fs/file-max" or the value in " ulimit -HSn =
####" ?
4) Is the default value below for =
"/proc/sys/net/ipv4/ip_local_port_range" , the " =
and " cat /proc/sys/kernel/threads-max" alright or should I increase =
My system : Red Hat ES 3.0, Kernel - 2.4.21-9.0.1, glibc version =
2.3.2-95.6 ( System: HP ML 530 with 2x3.0GHz Xeon
CPU, 8GB Mem 6x35GB for cache)=20
#cat /proc/sys/fs/file-max
#cat /proc/sys/net/ipv4/ip_local_port_range
32768 61000
#cat /proc/sys/net/ipv4/tcp_max_syn_backlog
# cat /proc/sys/kernel/threads-max
Info from Cache Manager
File descriptor usage for squid:
Maximum number of file descriptors: 1024
Largest file desc currently in use: 780
Number of file desc currently in use: 729
Files queued for open: 0
Available number of file descriptors: 295
Reserved number of file descriptors: 100
Store Disk files open: 43
Thanks in advance for the help.
RMIT University


text:
Mood: hungry
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"You would think we would stop celebrating the birth of the worst imperial power in history. But noooo, we have to do this flag waving #$%$ every year. I cannot believe I have to miss a good day of golf for this #$%$! I could have been at Oakmont with Jay-Z now trying out that new Callaway set Alec [Baldwin] gave me last year! God, this holiday sucks! All this national pride #$%$ gets on my nerves." ~ Barack Hussein Obama (occupant of the White House, caught by a microphone left on as he made his way from the podium during a July Fourth Independence Day speech).
This alleged quote is nonsense. I have spent too much time with The President in 2008. He doesn't use bad language. It just is not his way of speaking.


text:
June 18, 2014|11:09 am
(Screenshot: TheSharkpunch/YouTube)
Jim Burgen of Flatirons Church in Lafayette, Colo. takes on the hot topics of alcohol and medical marijuana use in this sermon excerpt that's making its way around the internet. The YouTube video is titled "A pastor gets it right about alcohol and marijuana." What do you think of his stance?


text:
Grimaldi's Brooklyn Still Firing Away
Wasn't this place supposed to have closed yesterday?By Alan Sytsma
Wasn't this place supposed to have closed yesterday?By Alan Sytsma
One of New York City's most popular pizza dens is going through some serious changes.By Alyssa Shelasky
Thanks from the F train.By Alyssa Shelasky
Now he "Just Can't Get Enough" unobstructed river views.By S.Jhoanna Robledo
Grimaldi's should still be okay.By Alyssa Shelasky
The food scene in Dumbo is finally catching up.By Alyssa Shelasky
Get ready.By Bennett Marcus
Dumbo dwellers have high hopes for AlMar.By Alyssa Shelasky
The Noma-trained chef says the produce will be local, but there won't be any reclaimed wood in the dining room.By Alyssa Shelasky
Where will fruit flies strike next?By Hugh Merwin
Free Wi-Fi for everyone!By Dan Amira
Plus: 50 percent off pizza, an Allman Brothers happy hour, and more, in our daily roundup of neighborhood news.
Plus Sixpoint Brewery celebrates its sixth anniversary in Prospect Heights, and more, in our daily neighborhood watch.
Dumbo's Digital District gets a rebrand.By Nitasha Tiku
Are hipster movie theaters the new hipster bowling alleys?By Daniel Maurer
Plus: Leona's at the Helmsley Hotel adds 19 percent gratuity, and four new vendors will open at the Open Air Café in the East Village, in our daily roundup of neighborhood news.
And Bobo's garden is reopening also.By Daniel Maurer
Plus: A crêperie on Grand Avenue, and Scarpetta turns two, in our roundup of daily neighborhood news.
Two chef shuffles today.By Daniel Maurer
Plus: U.K. Beer Night at Jimmy's No. 43, and another Chipotle opens, in our daily roundup of neighborhood food news.By Sam Dangremond and Stefanie Roberts


text:
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Hi! My name is London
I am a Siamese from logan, UT
Nicknames: Porky and crazy
Age: 9 years old
Gender: M
Coat: short haired
Education: nothing right now
My favorite tricks and treats are: running up the couch when your sleeping. and cat food
Where I hang out: under the bed
My favorite grubs: bananas and cheese
My pet peeves: he hates closed doors
What I love about my owners: she is down right fun to play with.
My cat hobbies: sleep and play
Pet motto: dont mess with my toes or you'll be sorry.
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well he almost died from a terrible eye infection so i adopted him.
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PROFESSOR TEACHES INTERNET EXPLORER 9Item#: YYP1-X8UW227R8JJ26NC | Model#: PTINTERNETEXPLORER9
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Professor Teaches Internet Explorer 9 uses lessons and interactive exercises developed by experts to help you learn how to use the world's number one browser: Microsoft Internet Explorer 9.
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text:
The Study of Man.
By Michael Polanyi. Price, $1.75. Pp. 102. University of Chicago Press, 5750 Ellis Ave., Chicago 37, 1959.One subtitle to Polanyi's challenging and fascinating book might be The Evolution and Natural History of Error, for Polanyi is at pains to expunge what he believes to be the false notion contained in the contemporary view of science which treats it as an object and basically impersonal discipline. According to Polanyi not only is this a radical and important error, but it is harmful to the objectives of science itself. Another subtitle could be Farewell to Detachment, for in place of cold objectivity he develops the idea that science is necessarily intensely personal. It is a human endeavor and human point of view which cannot be divorced from nor uprooted out of the human matrix from which it arises and in which it works. For a good while
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Colts General Manager Ryan Grigson continues to place a great deal of emphasis on getting new faces on the team for the 2012 offensive line. New to the mix is former first round pick George Foster (2003 – Denver). To make room for the acquisition, Indy parted ways with fullback Ryan Mahaffey.
Foster has journeyed around the NFL, spending time with Denver, Detroit, Cleveland, and New Orleans. He also spent one season with the Omaha Nighthawks of the United Football League (2010-2011). Like the other offensive linemen Grigson has target, Foster is much larger than the Colts have traditionally used at 6-foot 5-inches tall and 338 pounds.
Foster built his reputation blocking for running backs Tatum Bell and Mike Anderson in Denver, along with helping the Broncos limit opponents to only 15 sacks on the season in 2004, a franchise record. He was a reliable starter early in his career but was cut by the Lions in 2009 and has not made a meaningful impact since.
The New Orleans Saints took out a flyer on Foster last season. Now he will enter a crowded competition with the Colts, and will boast the most NFL experience of any other linemen this summer and potentially during training camp.


text:
Crazy Creek HEX 2.0 LongBack Chair
Where to Buy
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Here's what other sites are saying:
HEX 2.0 chairs roll-up compactly, with their handy attached strap, for ultra-easy carrying. A built-in hanging loop makes clipping to a pack easy. And, they work great as sleeping pads for ultra-light backpacking too. Now what a great chair to have around the camp site, RV grounds, sporting event or concert. it rolls up and then become a great chair to rest relax with. It comes in different colors too so make your choice and pick one up today.
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