text:
With this the 26th issue of HOC, we are well overdue in featuring our energetic, globetrotting CEO of Rx Communications, Ruth Whittington.
I can say this with only a minor fear of being labeled a sycophant or worse, but Ruth is a model boss: knowledgeable, hard-working, and above all nurturing and empowering towards her employees.
A native New Zealander, Ruth graduated from Auckland University with a first class honors Masters degree in biochemistry and physiology. While doing her PhD she joined Adis, a major medical communications company, first as a medical writer, and then as publications manager for the journals Drugs, Pharmacoeconomics, CNS drugs, and Health Outcomes. She quickly developed close ties with the pharmaceutical industry clientele and moved into business development with Adis, writing strategic plans and developing innovative publication programmes.
In November 2000, Ruth founded Rx Communications. A consummate entrepreneur, she has overseen exponential growth in both staff and revenue for the company; she's also a highly innovative thinker, having chosen, while most medical communications companies are located in metropolitan areas, to place Rx in a small market town in North Wales.
As she puts it: "We could be located anywhere as long as it has a good road to the airport and good broadband telecommunications." The company numbers among its clients most of the major pharmaceutical firms… and has a global network of more than a hundred experienced freelance medical writers.
The Rx CEO says that her personal business philosophy is to deal with integrity and to bring love and passion to what you do; her best quality, she believes, is her ability to pick the right people. "I look for an openness to different ideas and a certain energy," she says. But even though she takes a kindly and benevolent approach to her staff, she is a perfectionist; moreover, she loves a good argument so long as it's dialectical and not diabolical.
Ruth has two young daughters, and says she wants to do more travel (are you serious, Ruth? You must have enough frequent flyer points to go to the moon); and to learn Welsh. Now there's a worthy ambition: trust me, Mandarin is much easier.
Dr. Patti Peeples: what a perfect name for the subject of HOC people! She tells me that the origin of the name is from Peebles, in Scotland.
Patti founded a website, www.healtheconomics.com, 16 years ago; and that made her one of the early adopters of the Internet. Today, she says, it's the number one website for health economists globally… with some 10,000 visitors a month.
The website is an umbrella for her consulting services. She calls it a mega website for health outcomes and health economics resources, and works with several companies in the pharmaceutical industry, including Pfizer, Genentech, J& J and GSK, as well as with related consulting companies. The site also provides employment information.
Patti came to her present position following a stint as director of medical affairs and outcomes research for Alza, now a J&J company, where she ran the Phase IV clinical trials. Before earning a PhD in pharmacy administration with an emphasis on health economics at the University of the Sciences in Philadelphia she was a product manager at Sandoz (now Novartis) with particular responsibilities for that company's heart, kidney, and liver transplant immunisation drug, Sandimmune.
Today, she says that this particular combination of experience and skills places her ideally to bridge the gap between clinical trials and marketing. Health economics affects so many different stakeholders, she believes, so the market has to tailor itself to each of them… recipients may be looking for different information and benefits depending on whether they are managed care organisations, hospitals, employers, or clinicians.
Of HOC, she says:"I like its conciseness, its breadth of issues and its targeted focus."
And when she's not running her health economics website and consultancy, Patti plays the guitar, and tries to cure what she calls 'nature deficit disorder' by providing children, including her twin eight-year-old boys, with a solid grounding in nature and environmental issues. In fact, she and her husband Steve Gustafson recently took an RV trip across the United States for 2 1/2 months. Part of the training she offers has to do with survival skills – surely an excellent capability for those in today's healthcare jungle. As she puts it: "My dream is to be stranded on an island for a year, with only a pen-knife."
On January 1st 2006, Dr Dennis Gross retired from Merck after 28 years; the following day, he took up his present position as Associate Dean, Masters Programs, in the College of Graduate Studies at Thomas Jefferson University.
At Merck, he had started out as a senior research pharmacologist working on the project team that discovered the angiotensin converting enzyme inhibitors Vasotec and Prinivil. Dr Gross went on to fill senior management positions in the company, directing research operations, and serving as director of programme resources and logistics. In that capacity, he was responsible for operations and financial oversight of Merck research labs in the UK, Japan, Canada, and Italy. He reckons that, all told, he flew a million and a half miles for Merck.
During that time, he fused a business career with an academic one… serving as an adjunct professor at Jefferson from 1977. No wonder Gross is a strong proponent of bringing 'real world' experience to the benefit of the 350 students in his masters programme in biomedical sciences. "It adds richness and diversity to the student experience," he says, and helps to prepare those students for what he believes will be a very different future in pharmaceuticals.
Many of the professors in the department lecture on what they actually do for a living, he says, and he himself grafts onto his administrative duties a teaching schedule in pharmacology and toxicology. "I really enjoy interacting with the students," he says, "and it really is a way of giving back some of what I learned in industry." And those students themselves are pretty diverse – some just out of undergraduate studies; others with perhaps 10 years in the business world.
Off campus, Dennis Gross enjoys music and photography… and is a voracious reader who's been collecting books – especially on the Middle East – for 40 years, prompted perhaps by the fact that his grandfather fought in Palestine in World War One and met the fabled Lawrence of Arabia.
Of HOC, he says: "The newsletter serves the useful purpose of exposing people in a succinct way to the issues of the day that affect them professionally."
A factor that has confounded the issue of adherence or compliance for 40 years is the actual pharmaceutical and the disease being treated. Thirty years ago we had an education tape at Merck about this issue: Keeping the Hypertensive Patient in Compliance.
The biggest problem with hypertension and high cholesterol is simply these diseases are asymptomatic. The patient does not sense anything wrong. They are likely to think: "why should I continue to take a drug that makes me feel bad regardless of how much it costs, even if it is generic?"
The patient was probably feeling fine with their high cholesterol, osteoporosis or high blood pressure and now we prescribe them a drug that makes them feel worse and restricts their lifestyle.
For the drugs used to treat osteoporosis they cannot take the medication with food for at least 30–60 minutes; they can drink only water with the pill, and they cannot lie down and, by the way, the medication won't really do anything for them for at least 9–10 months and we won't really know what it is doing for them unless they fall and don't break a hip.
Why should they continue to adhere to something with lots of side-effects and no visible positive outcome – getting heartburn every time they take their osteoporosis drug or postural hypotension from their high blood pressure medicine? Cleaner side-effect profiles may be the key to adherence – not price.
Entusiasmo. That's a word that describes, in his native Italian, what Vittorio Maio brings to his work in health policy and outcomes research. "What makes me really happy," he says, "is being able to see research theory translate into actual practice in the real world."
Vittorio graduated from the University of Perugia and moved to the United States in 1999; there, he immediately joined Dr. David Nash's Department of Health Policy at Thomas Jefferson Medical College, where he is a research assistant professor and director of the Fellowship programme in outcomes research.
But he has not lost touch with his professional and cultural roots. A few hours after our interview for this article, he was winging his way back to Italy – a trip he makes four or five times a year. In Bologna, he conducts population-based outcomes research with a unique healthcare database. The studies embrace differences in the use of health care services between men and women, the elderly, and children; they look at approaches to, say, cardiac care and how general practitioners might be persuaded to change their approaches to treatment and prescribing. They are even touching gently upon the idea of pay-for-performance among physicians.
Vittorio brings this international perspective to his professorial role at Jefferson. He finds that his students are particularly receptive to this… and he is not afraid of editorialising on the subject of American healthcare, which he describes as the most regressive system in the world. "We all pay the same," he says. "People should pay according to their resources."
In general, Vittorio's particular research enthusiasm has to do with the elderly, with trying to change physician behaviour, and with pay-for-performance – linking quality to incentives. Beyond that, he says, non-adherence to drug regimens "is a huge interest."
Asked about HOC, he is equally upbeat: "What you're doing," he says, "is an important way to connect health economists, researchers and decision-makers. It's concrete, an easy read, and credible."
US News and World Report calls him a patient safety guru; Modern Healthcare has repeatedly named him among the top 100 most powerful people in American healthcare; his curriculum vitae runs to more than 70 pages, of which one whole page is devoted to his multiple honours and awards.
Dr. David Nash is chairman of the Department of Health Policy at Jefferson Medical College, an integral unit of Jefferson Medical College and of Thomas Jefferson University Hospital, which was founded in 1825. The Department employs 42 people from an eclectic range of disciplines including pharmacy, public health, medicine, nursing, and administration.
Funding for the Department's current range of 36 active projects comes from the pharmaceutical industry (40%); government (10%); and the remaining funding comes from a mix of both the private and public sectors. Among those projects are technology assessment; cost effective analyses;, diffusion of technology into medical practice; and policy pieces for differing audiences, including State government.
Specifically, the Department's research team focuses on health services and outcomes projects in such areas as: clinical care quality measurement for hospital departments; productivity measurement associated with specific disease states; disease management outcomes measurement; senior health issues; and value-based healthcare purchasing for employers.
The Department produces numerous articles and research papers, as well as publishing four journals: American Journal of Medical quality; Disease Management; Biotechnology Healthcare; and Pharmacy and Therapeutics. David Nash serves as editor of all four.
There are several cutting edge policy issues currently attracting the Department's interest. These include retail, in-store clinics; the US physician shortage, particularly in primary care; the growing issue of compliance with drug regimens; and the specifically US concerns over malpractice litigation, and the roughly 50 million Americans who are uninsured. So far as the issue of retail medicine is concerned, Nash is a strong proponent. What they offer, he says is access, convenience, and price transparency. In fact, he chairs something called the Take Care National Medical Advisory Board, a company in the retail medical business. (HOC will publish an article on these retail clinics in our October issue).
So far as the doctor shortage is concerned, Nash believes that while this is due to the usual suspects – overutilisation of services, an aging population and increasingly sophisticated technology – a more significant cause is what he calls the feminisation of medicine. More than half of the entering class of US medical schools are women … who tend to work fewer hours and have shorter careers.
The Department of Health Policy is appropriately involved in continuing education. It has a cadre of external Fellows and Senior Scholars, puts on a number of conferences each year, and operates ,jointly with Jefferson's College of Graduate Studies, a Masters program in public health.
Having seen Dr Nash in action over several years, I can say that he also brings to his extraordinarily full professional life a talent for public speaking, and marketing … and for inspiring loyalty and enthusiasm among his staff.


text:
Some of the weather-related terms heard in our field trip:
ATMOSPHERE | a gaseous envelope that surrounds the Earth. Other planets of the solar system, as well as a few of the large satellites of the outer planets, also have atmospheres, though each one has a different mixture of gases. Earths atmosphere consists primarily of nitrogen and oxygen. This envelope, commonly called the air, also contains numerous less abundant gases.
AVIATION FORECAST | a forecast put out by the short-term forecaster which gives aircraft pilots important information about weather conditions both on the ground and up in the air. One critical function of this forecast is to warn pilots of a possibly dangerous condition known as wind shear.
ADVANCED WEATHER INTERACTIVE PROCESSING SYSTEM (AWIPS) | a computer system that collects and crunches data gathered from radar, satellite, and other data collection devices at NWS offices around the country to produce a snapshot of what the atmosphere will look like at a given time. This system is used extensively by forecasters to create different types of forecasts. The weather events simulator, a training tool, is also part of the AWIPS.
CLIMATE | the average weather pattern in a given place over many years.
COMPUTER MODEL | a data-driven system that uses a built-in set of rules to predict the results of a process or to simulate how a given set of conditions will change over time. By comparing the models predictions to experimental and observational results, scientists can refine the underlying rules to make the model itself more accurate. The AWIPS, seen in action during the field trip, is an example of a computer model of the atmosphere. As data about current wind conditions, precipitation, cloud cover, temperature, and other variables is fed into it from various places around the world, it uses sophisticated built-in theories about how those variables interact to predict how the atmosphere will respond over the next seven days.
COOPERATIVE WEATHER OBSERVER PROGRAM | a project involving more than 11,000 volunteer weather observers across the country who record daily temperature and precipitation data. They may also report additional information such as soil temperature, evaporation and wind movement, agricultural data, water equivalent of snow on the ground, river stages, lake levels, atmospheric phenomena, and road hazards.
DOPPLER RADAR | a specialized form of radar used in weather forecasting. Unlike ordinary radar, which can report only the location and strength of precipitation, Doppler radar is also capable of indicating wind direction, wind speed, and boundaries between warm and cold fronts. Doppler radar may also be referred to as WSR 88-D or NEXRAD.
HYDROLOGIST | a scientist who studies the distribution, circulation, and physical properties of underground and surface waters as well as the form and intensity of precipitation, its rate of infiltration into the soil, its movement through the earth, and its return to the ocean and atmosphere.
LONG-TERM FORECASTING | the creation of extended forecasts to predict weather patterns as much as a week aheada very important tool for anyone planning an outing or an event like a vacation or wedding!
METEOROLOGIST | an atmospheric scientista scientist who studies the atmospheres physical characteristics, motions, and processes and how they affect the rest of our environment. The best-known application of this knowledge is forecasting the weather.
NATIONAL OCEANOGRAPHIC AND ATMOSPHERIC ADMINISTRATION (NOAA) | a federal agencypart of the U.S. Department of Commercethat conducts research and gathers data about the global oceans, atmosphere, space, and sun and applies this knowledge to science and service that touch the lives of all Americans.
NATIONAL WEATHER SERVICE (NWS) | a government agency under the auspices of the U.S. Department of Commerce and the National Oceanographic and Atmospheric Administration. The NWS is the primary source of weather data, forecasts, and warnings for the United States. Television weathercasters and private meteorology companies prepare their forecasts using this information. The NWS is also the sole official voice in the United States for issuing warnings during life-threatening weather situations. The NWS mission is to protect the life and property of our citizens from natural disasters by issuing warnings and forecasts for all manners of severe or extreme weather and to enhance the national economy.
NOAA WEATHER RADIO | a nationwide network of radio stations broadcasting weather information from a nearby National Weather Service office around the clock.
PRECIPITATION | different forms of water that fall from clouds in the sky. Some types of precipitation are rain, snow, hail, and sleet.
RAIN GAUGE | an instrument that collects and measures rainfall. NWS will install rain gauges free of charge for volunteers participating in the Cooperative Weather Observer Program.
SHORT-TERM FORECASTING | hour-by-hour monitoring of weather conditions in order to provide warnings about possible severe weather, including aviation forecasting of wind shear and other possibly dangerous weather events.
TORNADO WARNING | A warning means that an actual tornado has been sighted in the area or detected by weather radar. Seek shelter immediately!
TORNADO WATCH | A watch means that conditions are favorable for tornadoes to develop, so stay alert for changing weather.
WEATHER | the mix of events that happen every day in our atmosphere, including temperature changes, winds, rainfall, and humidity. Weather is not the same everywherein fact, it can be different in different parts of town at the same time!
WEATHER EVENTS SIMULATOR | An AWIPS computer system used to play back or review past weather events collected from NWS offices around the U.S. This system is used as a training tool: Meteorologists can examine a set of conditions from the past, make a weather prediction based on that data, and then compare their forecast to what actually happened.
WIND SHEAR | a dramatic change in wind speed and/or direction within a short distance. These sudden bursts result in shearing forces that can cause problems for airplanes by putting extra stress on their component parts.
- NSSLs first Doppler weather radar, located in Norman, OK. 1970s research using this radar led to the NWS NEXRAD WSR-88D radar network. Photo courtesy NOAA Photo Library, NOAA Central Library; OAR/ERL/National Severe Storms Laboratory (NSSL).
- A tornado just south of Dimmitt, TX on June 2, 1995. Photo courtesy NOAA Photo Library, NOAA Central Library; OAR/ERL/National Severe Storms Laboratory (NSSL).
- Atmosphere. Encyclopædia Britannica from Encyclopædia Britannica Premium Service.
- NOAA Public Affairs
- U.S. Department of Labor Bureau of Labor Statistics Occupational Outlook Handbook.

subset: commoncrawl


text:
Why Book With Us
- No booking fees
- Flexible cancellation policies
- 24 hour customer service
- Like booking hotel direct
- Privacy
- Security
Email Offers
Frankfurt, Germany Attractions
Shopping Street Zeil
Zeil is the epicenter of shopping in Frankfurt, where half a million people shop every day, and where the turnover of shops on this constantly changing stretch of prime retail real estate is the highest in Germany. Anchored by major department stores such as Galeria Kaufhof, Karstadt and Peek & Cloppenburg, the Zeil is also home to global fashion retailers such as H&M. At the futuristic Zeilgalerie, the complex's roof terrace offers dazzling views of Frankfurt. Another retail center on Zeil is MyZeil, an ambitious combination of shopping and entertainment which sprawls across eight floors.
view all city hotels view all hotels on the map


text: s Max & Erma's: Gift Cards Buy Gift Cards Join Good Neighbors Say Thank You Quick links How to order Buy a Plastic Gift Card Buy an eGift Card Balance Check Gift Cards Want to know the quickest way to send a burger?... Order gift cards online! Buy a Plastic Gift Card Order today, we'll ship 'em to the lucky recipient! Buy an eGift Card Need an Immediate Gift they can Redeem Right Away? Pick your card design, add some cash, we'll email it -- so they can print and use today! Balance Check Check your balance right now! © 2016 – Max & Erma's Restaurants, part of Glacier Restaurant Group, LLC Contact Us


text:
1. Purpose
Is there a section that explains the resource's purpose,
e.g., "This is what we're doing, and why we're doing it..."
Is scope specifically stated? Do the contents match the stated scope?
Who is the intended audience?
What is the host's motivation for providing the information
on the Web? Advertising for profit, part of agency's mission,
educational purposes, publicizing a particular agenda?
Information about the site can be obtained by examining
the last three letters (domain code) of the host address:
.com = commercial source
.gov = government agency
.org = non-profit organization
.net = consortium (profit or non-profit)
.edu = educational institution
2. Content
Is the information accurate?
Is the information verifiable?
Is point of view stated?
Is objectivity a factor?
Is the text well written? Is it written in the language of the
Who is the intended audience of the source?
Does the source have features, such as charts, illustrations,
or a bibliography, that will be helpful?
What sources did the author use to gather the information?
Is the method of obtaining data accurate and dependable?
Are the links to other resources up to date? Are links to
other Web resources labeled clearly?
Is the page finished, or still under construction?
3. Authority
Who is the author?
What is the status of the author?
Can author be contacted?
Is the publisher reputable?
Does the author provide any credentials demonstrating
expertise and/or knowledge of the subject?
Does the institution or organization supporting the Web
page identify its address and phone number? Does it clearly
state the mission? Does it have an established reputation?
Is the information needed to prepare a citation easily found?
4. Currency & Accuracy
How frequently is the resource updated?
Are facts, such as statistics, verifiable? Is the source of the information cited?
Does the resource contain grammatical, spelling or typographical errors?
Does the Web page indicate the last time the information was updated?
Is there a stated commitment to regular updating and
maintenance of the information?
See also


text:
And I've been in touch with a therapist. Even though she's booked solid, she's helping me find another therapist who would be a good match.
Last thing: Today I'm going to a new CrossFit gym near me. I'm cautiously hopeful, because while I really liked the few weeks of CF I did last year, that particular gym was way too advanced for newbie me. The trainer/owner of this new facility swears by safety first and working closely with members to ensure proper form and adequate weight. Fingers crossed...
I hope everyone is having a fabulous Day 27 (or whichever day it is for you)!
Glad to hear you are feeling better Jackie! We are all rooting for you!
Day 27... I'm sad to see how close I got to doing the whole month... 23 days and I had to call mine off. Stupid antibiotics.
Looking for a good probiotic to build myself back up with after the antibiotics are finished. Once I finish the antibiotics, I fully intend to go back to dairy free. These last few days with dairy have left me feel oh so bloated!!
You guys are doing awesome! I can't wait to see your final results!
Is there a whole 30 for july thread started yet?
And I don't think anyone has begun a Whole 30 for July thread yet.
Day 27: Today my younger son and I drove 3 hours each way to a big city to visit older University Son. B: Bulletproof coffee. L: Beef Tenderloin salad at a Tony Roma. About 5 oz freshly grilled beef on a plate of greens and tomatos. Picked off the croutons, reluctantly ate the little bit of shredded cheddar, used minimal balsamic vinaigrette dressing. Was hungry by mid-afternoon (not enough fat) so was eating fresh peas and fresh raspberries in the car. Finally stopped and bought a pepperette for the fat content. S: Can of brisling sardines with olive oil and Mediterranean spices, black olives. About a dozen local fresh strawberries. Now a cup of tea.
Too many hours in the car. I'm bushed.
I have decided that starting Sunday, I am going whole30 again. I'm going to use the remaining time I have before my next whole30 to take care of any cravings I had while on the Whole30 last time - i.e. cream cheese pancakes.
I have enlisted the help of a refrigerated probiotic capsule to kick this candida overpopulation and no longer see the need for yogurt (thank heavens b/c it was making me bloated to beat hell!).
However, I am also dropping into "Last Supper Mode" where I eat/drink non-primal crap too - jelly beans from the office down the hall, mt. dew, hand made candies from the health food market (it's a very vegan store, so I highly doubt the candy is even close to primal), etc. Diet mentality. I need to get rid of it... but, there's nothing in the Primal Blueprint that says you can't enjoy a forbidden fruit once in a while - 80/20, right?
Anyway, I'll be starting up on either Sunday or Monday, I haven't decided just yet. I usually do my grocery shopping on Sunday, so it'll depend on whether not I get that done and have a whole lot of Whole30 approved foods on Sunday or not.
I'm so excited to see what everyone's end stats are! And I can't wait til the end of July when I'll have new stats to share too. This is so exciting to me b/c I lost 10 lbs in the 3 weeks I was W30, so I can just imagine what another 4 weeks will do!


text:
Southlake Campus
Pavilion B
200 East 89th Avenue
Merrillville, IN 46410
Having the only Gamma Knife in Northwest Indiana exemplifies Methodist Hospitals' commitment to providing world class care.
Gamma Knife radiosurgery is a non-invasive, outpatient procedure used to eliminate tumors and other malformations deep within the brain. Located in the Center for Advanced Clinical Studies (CACS) at the Southlake campus, this non-surgical instrument delivers high dose, intensive radiation with pinpoint accuracy, sparing surrounding tissue.
The Gamma Knife team is comprised of medical specialists who work together to determine the best course of treatment and follow-up care. It includes a neurosurgeon, radiation oncologist, radiation physicist and specially trained Gamma Knife nurse and support staff.
Gamma Knife radiosurgery may be the best option for a variety of situations. These include brain lesions, malformed blood vessels (AVM), facial pain relief for trigeminal nerve problems, pituitary tumors, and acoustic neuromas.
Patients who are seeking a second opinion and think they might be a candidate for Gamma Knife radiosurgerymay are encouraged to call Methodist Hospitals' Gamma Knife Center to schedule a free screening.
An oncologist and a neurosurgeon will review the patient's MRI films to determine whether or not they are an appropriate candidate for the procedure. If it is indicated, we will conference with the patient's primary care physician before scheduling radiosurgery.
Free Stroke risk assessment and PAD Screenings: Blood Pressure and Carotid Bruit Check
To register call 1-888-909-DOCS (3627).
A support group for friends and family of people with multiple sclerosis.
For more information call 219-738-4926.
24/7 Physician Referral.
Contact Methodist Hospitals
© 2009 - 2016 Methodist Hospitals. All rights reserved. Web Development by alligatortek.
Remote Access
Get Driving Directions


text:
Advocates report surge in outreach efforts to uninsured Americans
WebMD News from HealthDay
'Obamacare' Enrollment Reaches 4 Million
By Karen Pallarito
HealthDay Reporter
WEDNESDAY, Feb. 26, 2014 (HealthDay News) -- Nearly 4 million Americans have signed up for health insurance through the Affordable Care Act's federal and state marketplaces since October, the Obama administration announced Tuesday.
With almost five weeks remaining in the current enrollment period, roughly 700,000 people selected a health plan in February alone, according to published reports.
In a blog posting, Marilyn Tavenner, administrator of the U.S. Centers for Medicare and Medicaid Services, cited "strong demand nationwide" for affordable health coverage.
The health insurance marketplaces, or exchanges, serve as the gateway for coverage through private health plans established under the Affordable Care Act, or "Obamacare."
The administration's last official enrollment report, released earlier this month, indicated that 3.3 million people had selected a marketplace health plan from Oct. 1 through early February.
Advocacy groups are reporting a whirlwind of activity this month as they try to enroll as many uninsured Americans as possible before open enrollment ends on March 31.
In Miami, the national enrollment campaign Get Covered America has partnered with local government and civic organizations, colleges, universities and religious organizations on various outreach activities, particularly targeting the metropolitan area's vast Latino community.
"We're continuing our efforts from now until the end of the enrollment period, and will continue our multi-pronged approach," Milton Vazquez, Get Covered America's Miami field organizer, said during a Tuesday press briefing on Latino enrollment sponsored by the Center for American Progress Action Fund.
Even at 4 million, the number of people who have signed up for one of the new marketplace health plans falls short of expectations. The U.S. Congressional Budget Office had projected 6 million sign-ups in 2014.
But the bungled launch of the federal marketplace website, HealthCare.gov, and technical difficulties experienced by some state exchanges made enrolling difficult, if not impossible, in the early days and weeks of enrollment. Having worked out the bugs and expanded computer system capacity, federal and state officials are reporting what they call an encouraging uptick in enrollment.


text:
Find free personals at Date.com's Cedar Bluffs dating service. Tired of speed dating? Try speed dating online with Date.com's matchmaking service. Whether you are looking for serious relationships, friendship, girlfriend, boyfriend, lover or even pen pals, Date.com has it all. Create a FREE singles ad and start Cedar Bluffs dating online, its easy!
Cedar BluffsJoin Now Free!
Cedar Bluffs Girls | Cedar Bluffs Men | Cedar Bluffs Gay | Cedar Bluffs Lesbians
More Cedar Bluffs Links:
Singles | Personals | Chat | Speed Dating | Love
Cedar Bluffs Catholic Dating | Cedar Bluffs Christian Dating | Cedar Bluffs Muslim Dating
Cedar Bluffs Black Dating | Cedar Bluffs Asian Dating
Date.com is a FREE online Cedar Bluffs dating service for singles. We have the hottest attractive and available Cedar Bluffs women/men on the Internet from hot blondes to cute brunettes to sexy redheads. If you are looking for a wife or husband for a happy marriage, mature ladies, older men create a free profile today. Browse our personal ads, chat online and start Cedar Bluffs dating today.


text:
New subscription
Renew my subscription
Give a gift
Pay my bill
Change my address
Active within 2204 Days
Hi! My name is Neko
I am Domestic Shorthair from El Paso, TX
Nicknames: Neko-chan
Age: 8 years old
Gender: F
Coat: short haired
Education: Caught birds, bats, mice...
My favorite tricks and treats are: Put a dead bat/bird next to her pillow
Where I hang out: Backyard
My favorite grubs: can food with chicken and/or salmon
My pet peeves: When my owner is playing the piano, she doesn't play with me.
What I love about my owners: She never get upset, whatever I do. She loves me a lot.
My cat hobbies: Hunting, sleeping, roam, waking the owner up at 4am.
Pet motto: Live happily
See all awards »
Her friend found me on a street in a cold winter day. He brought me to her house and asked her; "Do you like cat?"
I've had 681 friends visit me.
I'm the 42,423rd member on CatChannel.com.
32 friends have voted for me since I joined Club Cat!
Come visit me, Casper, "Daddy's Angels" Leo and Tigger & Sahara and the Girls.
Come visit me, Lilac & Sky--Thanks so much for COTD 1-30-10!.
Come visit me, Siegfried & Stewart.
Tell a Friend |
Report inappropriate content on this page.
Hi, my name is
Prince Sebastien - going to check out the tunnels.
Visit the photo gallery to cast your vote »
Get quick tips for happy cats, food recall info, news alerts and best behavior advice.
Sign up to get updates delivered straight to your inbox.
CatChannel takes your privacy seriously. To learn more, please read our privacy policy.


text:
Oklahoma City Zoo and Botanical Garden on Friday, November 9th is Kid's Choice Day. On a Kid's Choice Day, kids get to bring an adult to the Zoo for free. Buy one child… read more...
Botanical Garden
Oklahoma City Zoo and Botanical Garden – FREE Adult Admission with Purchase
Find more in : Misc. Deals, Oklahoma Deals, Oklahoma Events


text:
Digital timers kept running as Robin Seufert struggled to switch out one toilet flusher for another and to install a locking door knob.
Yet despite the tension, she came away with her enthusiasm intact - and knowing that a final event would follow where small hand-built cars go head-to-head on a track.
"I'm the only girl with a car in the race, I'm the Danica Patrick," joked Seufert, comparing herself to the trailblazing female NASCAR driver who races men every weekend.
Seufert, who works at The Villages apartment homes, took part April 30 with a few dozen fellow apartment staffers - all men - in the Charleston area's edition of "Maintenance Mania."
She's a groundkeeper, "so this is all new to me." That begs the question, Why take part? "They told me I didn't have any choice," she quipped.
As it turns out, Seufert had a pleasurable time tackling the eight maintenance challenges, in which participants are judged by speed in solo chances.
"I enjoyed it, my first time," she said. Her toughest job, she said, was the dual flusher conversion, while her favorite test was the lock installation.
The Charleston Apartment Association handles the duties as local sponsor of Maintenance Mania, including last month's event at the Belfor disaster recovery and property restoration warehouse in North Charleston.
Rules are spelled out in printed show pamphlets.
Supervisors and other crew sign up to attack the handyman-related tasks on specially designed stations. Judges explain the process and keep tabs on the participants. The racers must tap a bumper to trigger the clock, assemble a handful of supplies in a bucket, run to the far end of a table to begin the task, then when finished speed back and slap the bumper to post a time. The judges check to make sure the contestants finish all the tasks. Each participant gets two tries.
Once the eight challenges are completed, the participants go head-to-head in the hand-built car races.
While designs can be elaborate or simple, they must include at least three items that would be in a worker's toolbox such as cabinet knobs, switch plates, light bulbs and caulking tubes.
Maintenance Mania goes on nationwide, under the auspices of the National Apartment Association. Local winners can advance to state, regional and U.S. competitions. The national final this year takes place in Denver.
But if this all seems a bit obsessive, it's not, at least here. Participants try their best, but the evening is set up as a casual social gathering where apartment staffers can unwind and have a little fun. The judges likewise are apartment maintenance staff. Food and beverages are served. Nobody takes things too seriously.
"It's fun," said Jonathan Kuck, supervisor of the Traditions apartment village in Summerville. He took part to try out the challenges and to encourage some of his staff to try out.
"It's been going great: conquering my fears," said Hezikah Mangham of Carter Hasting.
Nick Poole of Riverstone Residential was taking part in his second "Mania." He won the car race last year. His secret?
"I'm not saying," he replied, "(but) no one else is doing it."
Reach Jim Parker at 937-5542 or firstname.lastname@example.com.
Robin Seufert, the only woman in the Maintenance Mania competition, tries out the refrigerator hose connection (Jim Parker/Staff 4-30-2014).×
Hezikah Mangham of Carter Hasting tries for a fast time in hooking up a water faucet. He was one of about 30 property technicians to take part in the CAAs Maintenance Mania event April 30 in North Charleston (Jim Parker/Staff 4-30-2014).×
A variety of cars made out of maintenance parts were built for the downhill race at the conclusion of Maintenance Mania (Jim Parker/Staff 4-30-2014).×
Michael Moore with MAA takes his turn at converting a toilet from one type of flush to another (Jim Parker/Staff 4-30-2014).×
Michelle Lorick (left) of High Associates and a judge in Maintenance Mania, shows Nick Poole of Riverstone Residential what he needs to do in the flush conversion race (Jim Parker/Staff 4-30-2014).×
The eight events take place simultaneously at Maintenance Mania. Winners of local contests can make it all the way to Denver for the national title (Jim Parker/Staff 4-30-2014).×
Chris McLeod with Greystar pushed the button to lock in his time in the flush conversion rally (Jim Parker/Staff 4-30-2014).×
As guests eat and talk, racers prepare for heats in the Maintenance Manias last event April 30 at Belfor disaster recovery company in North Charleston (Jim Parker/Staff 4-30-2014).×
This property crew member puts together a ceiling fan at the annual Maintenance Mania fest (Jim Parker/Staff 4-30-2014).×
Jonathan Kuck, maintenance supervisor of Traditions in Summerville, carries his supplies to the far end of the course to install tubes on a faucet during the Maintenance Mania last month (Jim Parker/Staff 4-30-2014).×


text:
About Us
Submit Press Release
Mobile & Palm
Security & Privacy
Other Security & Privacy
Internet Explorer Password
Internet Explorer Password Full Description
Use Internet Explorer Password to find Content Advisor password and turn it off!
Full Description
LastBit Software
31, July 2005
61 Kb
$25 to buy
Download Internet Explorer Password »
Product Info
Internet Explorer Password is a password recovery program for IE Content Advisor. Content Advisor was initially designed as a security feature and a tool to monitor website ratings to prevent minors from accessing adult websites. Since the rating technology never became widespread, this feature is basically useless, and may effectively block the usage of Internet Explorer. If you lose or forget a password to your Content Advisor, you will be unable to use Internet Explorer, since most websites have no rating at all. Internet Explorer Password solves this problem by recovering a password and letting you turn the Content Advisor off.
What's new in current version
Improved recovery engine.
A standard Windows PC
Please contact Internet Explorer Password publisher,
LastBit Software
if you have questions or issues regarding this product.
Share Internet Explorer Password Review, IE Password: find Content Advisor password Page
Page URL:
Using a crack or a pirated serial or key generator to activate Internet Explorer Password full version without buying a license key is against the law.
Featured downloads
The award-winning Firefox Web browser has security, speed and new features that will change the way you use the Web. Don t settle for anything less
Download now!
Google Talk
Google Talk is a simple and free way to talk with and send instant messages to your friends.
Download now!
Adobe Flash Player
Flash Player is a cross-platform browser plug-in that delivers breakthrough Web experiences to over 98% of Internet users
Download now!
Related downloads
Advanced IE Password Recovery
A program to Recover passwords to web sites saved in Microsoft Internet Explorer (in local password list), as well as AutoComplete strings (form fields). It can also reset Content Advisor Passwords. IE versions from 3 to 6 are supported.
Atomic IE Password Recovery
Atomic IE Password Recovery recovers lost passwords saved by Internet Explorer AutoComplete in a while. The program removes the password of the Content Advisor in a while. AtomicIE also recovers passwords set for FTP catalogs.
Internet Explorer Password Recovery Master
This password recovery tool designed for viewing and cleaning the secret data stored by Internet Explorer. This includes managing passwords for protected sites, user passwords on forms, Content Advisor password and autocomplete strings.
LastBit Excel Password Recovery
Excel Password Recovery recovers Excel 4.0-2007 passwords using numerous attacks, providing a 100% satisfaction guarantee and offering your money back if it cannot unlock your XLS document in 36 hours (97% documents can be recovered within a minute).
Excel 2007 Password
Password recovery tool to crack Excel 2007 passwords to open. You pay only for the result. If the program fails to find the password, you pay nothing.
FREE Word Excel password recovery Wizard
If you have forgotten a password to an important Microsoft Word or Excel file, there's a good chance that you will be able to recover it using this free and easy-to-use utility.
Word 2007 Password
Password recovery tool to crack Word 2007 passwords to open. You pay only for the result. If the program fails to find the password, you pay nothing.
LastBit PDF Password Recovery
PDF Password is a password recovery utility for Acrobat PDF (*.pdf) files. PDF Password decrypts user and permission passwords only. PDF Password does not allow to decrypt DRM (Digital Right Management) system.
Ultimate ZIP Cracker
The Ultimate ZIP Cracker is designed for recovering the lost passwords for several file types: MS-Word and MS-Excel documents; ZIP, RAR and ARJ archives. The program is highly optimized for speed.
Related Press Releases
Survey Reveals That in Many Password Loss Cases Lost Password Recovery Helps
Gothenburg, Sweden, October 13, 2010 It has been found by the SysTools survey team that a large number of organizations have faced data loss and critical passwords loss situations, which badly affect their business operations. Most of these issues are solved by lost password recovery solutions. One such tool is SysTools Access Password Recovery software that helps users to recover MDB...
SysTools Launched VBA Password Recovery Tool To Recover VBA Password
Gothenburg, Sweden, July 26, 2010 SysTools VBA Password Remover Software is a tool launched recently by SysTools Group. This tool is extremely useful to recover VBA password from Microsoft Office utilities like Word, Access, PowerPoint, Excel etc. On the launch of SysTools VBA Password Remover software, Evan Swans (Director of Product Development, SysTools Group) gladly says, It is our...
Help is coming - OpenOffice Password Recovery is out to ease the trouble of password recovery!
Intelore, one of the key developers of password recoverysolutions, launched OpenOffice Password Recovery 1.0.4 a powerfull softwaretool designed to help absent-minded or careless PC users recover forgotten passwordsfor a suite of OpenOffice.org programs (Writer, Calc, Impress, Draw, Math etc.).OpenOffice Password Recovery 1.0.4 offers a suite of mechanisms and schemes toquickly and...
Stellar Launches All-in-one Office Password Recovery software to retrieve lost password for Word/Excel/PowerPoint files
Gurgaon, Haryana , Stellar Information Systems Ltd today announced the launch of Stellar Phoenix Office Password Recovery, which efficiently retrieves the lost/forgotten password for the Microsoft Word, Excel documents and or PowerPoint presentations. This all-in-one Office password recovery utility can recover the passwords to Open and password to Modify any Word, PowerPoint or Excel...
No need to be a hacker to recover a lost password from an Office document Accentsoft Team Releases Accent OFFICE Password Recovery 2 40
The Easiest Way to Recover Your Forgotten MS Office PasswordNowadays people are conscious about security of their data. Confidentialinformation is no longer a phrase from Bond-style movies but from every day life.We all have our secrets and we do not want to reveal them to other people. You maywant to keep in secret your personal documents, banking details, office documentsand...
No need to be a hacker to recover a lost password from an Office document Accentsoft Team Releases Accent OFFICE Password Recovery
No need to be a hacker to recover a lost password from anOffice document.December 1, 2005Accentsoft Team Releases Accent OFFICE Password Recovery 2.32Ever thought: "If I were a hacker...? " No, I don 't mean you 'd rob banks via theInternet. Being a hacker, though, you 'd never have to re-write an annual report justbecause of a lost password for an Office document. You...
Related software and technology conferences
Toronto The Total Turn Around Toronto May 29th, 2010
Digital Content Strategies Conference
Global Strategic Management Institute (GSMI) is excited to be hosting Digital Content strategies Conference (DCSC) 2013 in San Diego. DCSC will provide an outlet for educating corporate decision makers on the value of a comprehensive content strategy to further their business objectives and growth. Successful content strategy is much more than creating valuable content. Over the course of...
Content Strategy Workshops Portland
The practice area of content strategy has had its ramp-up years with content strategy theory. Enough! It's time to get serious about how to turn theory into practice. Experienced practitioners need a place to hone their craft from their peers, and new practitioners need a place to learn the ropes. This is the place. Building on the work done by the Content Strategy Applied team, Scott Abel...
ECM (Enterprise Content Management):Technology, Architecture, and SharePoint
In this course we will provide a thorough introduction to and grounding in Enterprise Content Management technologies. Explain clearly how they work and why they will become of increasing importance to you and your organization, particularly in this age of financial restrictions. This will be a highly critical and supplier agnostic workshop, championing no particular vendor technology...
6th Annual Intelligent Content Conference: Breaking Down Barriers
The sixth annual Intelligent Content Conference takes place February 26-28, 2014 at the Doubletree Hotel in San Jose, CA. The event will equip attendees with the knowledge they need to break down the barriers preventing them from connecting content with those who need it. More than 70 experts will present examples, standards, methods, strategies, and tools needed to deliver the right...
CBMI 2014 Content Based Multimedia Indexing workshop
Following the eleven successful previous events of CBMI (Toulouse 1999, Brescia 2001, Rennes 2003, Riga 2005, Bordeaux 2007, London 2008, Chania 2009, Grenoble 2010, Madrid 2011, Annecy 2012, and Veszprem 2013), the 12th International Content Based Multimedia Indexing Workshop aims to bring together communities involved in all aspects of content-based multimedia indexing, retrieval, browsing...
Privacy policy
Terms of use
Request review
Copyright @2006-2011, Softarea51.com


text:
TAG: Festivals & Events
Posted by: Feet Banks
There's more to Wanderlust Whistler than just yoga. There's concerts, movies, food and...prancing. Check out this Insider exclusive Prancing video!
The Insider's guide to how, where and what to watch at the Subaru IRONMAN® Canada
TAG: Family Time, Festivals & Events
Posted by: Feet Banks
Get sweaty, get muddy and go for gold. New events for Whistler in summer 2015.
TAG: Festivals & Events, How-To, Summer Fun
Posted by: Feet Banks
Whistler Village was designed to be a meandering path to discovery and few events take advantage of that like Artwalk.
Brought to you by Tourism Whistler


text:
Prvi Partisan .303 ammo any good
Tools and Technologies
Rifle Country
> Prvi Partisan .303 ammo any good
October 11, 2008, 06:56 PM
I saw some of this ammo at our local gun shop today and I'm in need of ya'lls input as someone told me it was downloaded. Is the brass good?
If you enjoyed reading about "Prvi Partisan .303 ammo any good" here in TheHighRoad.org archive, you'll LOVE our community. Come join
today for the full version!
October 11, 2008, 07:42 PM
I can't comment on the .303, but I've used their ammo in 30-06, both 150 and 180 grain. Good consistent stuff at a decent price.
October 11, 2008, 07:58 PM
Prvi Partizan everything is good. I also doubt that they download anything.
According to their website, they have 180 and 174 gr loads at 2460 fps, and 150 at 2690. Sounds right for .303 to me.
October 11, 2008, 08:40 PM
A buddy and I went in halves on a case of Prvi 5.56, it shoots well and the price is right. I will buy it again.
October 11, 2008, 09:37 PM
The brass holds up well; I easily got ten reloads out of the Prvi 303 Brit brass.
October 11, 2008, 09:49 PM
Is it non-corrosive? My local shop has a lot of it too lately. They also have the generic looking no-name boxes of .303 that are sealed with a paper seal...I don't know if it is corrosive or not either???
October 11, 2008, 09:51 PM
Shoots well, not light at all. Not my best reloading .303 brass, but still very good. If not outrageously priced I'd get a few boxes.
The Privi is NON-corrosive.
October 11, 2008, 09:52 PM
It is non-corrosive new manufacture. Avoid the POF ammo; it's very very bad stuff.
October 11, 2008, 10:03 PM
I rate PP ammo as excellent,very clean non corrosive ammo that gives good performance.It is up there with S&B ammo though S&B has a edge.
I have have shot 7mm,8mm,7.65 Argentine,6.5 Carcano,7.5 French,6.5 Swedish Prvi Partizan ammo always excellent quality.
Im my milsurps I use PP and S&B almost exclusively except 30-06 which I use HXP in those.
I never use corrosive ammo,the only corrosive ammo I might consider is the Yugoslavian M75 ammo.So I can vouch for PP ammo.
If you enjoyed reading about "Prvi Partisan .303 ammo any good" here in TheHighRoad.org archive, you'll LOVE our community. Come join
today for the full version!
vBulletin® v3.8.6, Copyright ©2000-2016, Jelsoft Enterprises Ltd.


text:
The Memorial Experience
- All Stories
- Cancer Stories
- Cardiac Stories
- Neuroscience Stories
- Rehabilitation Stories
- Robotics Stories
- Trauma Stories
- Wound Healing Stories
- Orthopedic Stories
- Other Stories
- Employee Stories
- Memorial Experience Letters
Memorial's Comprehensive Blood Disorder Treatment Keeps
Patient Close to Home
Louise, 86, has myelodysplastic syndrome (MDS), a bone marrow disease that may cause anemia, heightened susceptibility to infection, and, in one-third of all patients, leukemia. Fortunately for Louise, Memorial Cancer Institute's Leukemia, Lymphoma and Bone Marrow Transplant (BMT) Program offers leading-edge treatment options. The only comprehensive blood cancer treatment center in Broward and Palm Beach counties, it is staffed by physicians with fellowship training from some of the nation's finest university cancer centers.
Three times a week, Louise's granddaughter Jackie takes her to Memorial Regional Hospital for injections of amifostine, which stimulates the production of healthy blood cells. On days when her blood count needs an extra boost, a blood transfusion is administered, too. Each outpatient visit can last for hours, but the time passes quickly because of the easy rapport between Louise, Jackie and the staff.
"The nurses always have a smile for us, and they're available to help us at the drop of a hat," says Jackie, 30. "They're the right people to have in this environment. You get to know them personally."
A Community Taking Care of Its Own
"Our goal in creating the Leukemia, Lymphoma and BMT Program was to give patients in our community access to a huge support system of specialists and a broad range of treatment options," says Louise's physician, Lyle Feinstein, MD, Director of the BMT Program.
"I like him because he's always up on things. He's thorough and knowledgeable, but never an alarmist," says Louise.
"He's also very personable and funny," says Jackie. "My grandmother is so loyal to him."
A Florida native, Dr. Feinstein brings a special brand of empathy to his practice because he himself is a childhood leukemia survivor. Today, one of his best friends and colleagues at the BMT program is Allen Greenberg, MD, the very same physician who diagnosed and treated him years ago when fewer treatment options were available locally. For Louise, it's a comfort to know Memorial Healthcare System now offers so many specialized services.
Louise and her husband, Carmelo, moved from Massachusetts to Florida 58 years ago, and they've lived in their current Hollywood home for the past 40 years.
"It's great to see how the hospital has grown," she says. "Memorial provides wonderful care – close to my home and family."
Is Your Doctor a Memorial Doctor?
To find a physician who is committed to South Florida healthcare services, call Memorial Physician Referral Service toll-free at (800) 944-DOCS. We're available 24 hours a day, 7 days a week.


text:
LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
The road to personalized medicine depends on development of biomarker assays that can reliably—with ultrahigh sensitivity and specificity—identify what is going on in the patient's system. At CHI's "Biomarker Assay Development" conference held recently in San Diego, several presentations focused on the challenges that continue to confront researchers as they progress toward this goal.
Among the speakers was Shannon Payne, senior scientist at Epigenomics. She described her group's identification of a region of the Septin 9 gene that is methylated in more than 90% of colorectral cancer (CRC) tissues, with little or no methylation in normal colorectal tissue and other controls.Because CRC typically develops with few or no symptoms, early detection is the key. The American Cancer Society's goal is to screen 75% of average risk people 50 years of age and older by 2015, Dr. Payne noted. The percent of people currently being screened is around 50%. The current standard noninvasive test, the fecal blood test, requires too much patient involvement in an unpleasant process and is used at a <14% compliance rate.
Including all existing screening test modalities, 61% of patients are first diagnosed with late-stage disease. Dr. Payne and others are confident that a blood-based alternative test method would increase patient acceptance of asymptomatic testing.
DNA methylation provides unique advantages, Dr. Payne noted. It is biologically relevant as fundamental to gene regulation and genome stability; it is a rich source of biomarkers for diagnosis, prognosis, and drug response prediction; it provides technically robust detection and quantification, which makes it ideal for the clinical routine; it can use both routine body fluid samples and paraffin-fixed samples; and—of no small importance—comprehensive patent protection of biomarkers and technologies makes it commercially attractive.
Using an Affymetrix microarray platform that was custom made for Epigenomics, Dr. Payne's group identified thousands of candidates identified as methylated in target tissue. From these the goal for optimal oncology biomarkers was to identify those with high methylation levels in target cancer tissue (high sensitivity) and low methylation levels in healthy tissue and other diseases (high specificity).
In one experiment, methylation levels were compared for the target CRC tissue samples, other cancers, healthy tissue, and benign disease. The sensitivity and specificity of the SEPT9 methylation was further characterized in a larger sample set and confirmed in real-time PCR studies. SEPT9 methylation was present in >90% of all CRC tissues.
As a member of the Septin family, SEPT9 has "its fingers in a lot of pies," Dr. Payne explained, including breast and ovarian cancer, myeloid-lymphoid leukemia (MLL), and many other malignancies. But its methylation is highly specific for colorectal cancer. Detection of minute amounts of methylated SEPT9 DNA shed by the tumor into the blood requires a highly sensitive real-time qPCR assay. The average amount of free DNA in plasma is 3–10 ng/mL, and the target DNA can be 1/1000 or less of that concentration.
Hence a biomarker assay must detect very low copy numbers. "We are looking for signal from a small tumor in a sea of blood," she stated. The test must detect all stages of disease; detect cases, not controls; have a low false positive rate; and be practical in the clinic. The Epigenomics process of DNA extraction, bisulfite treatment, and qPCR resulted in a 90% limit of detection equal to 6.9 picograms. When scaled-up it met all four goals: lower input volume of plasma, higher throughput, potential for automation, and lower cost.
Epigenomics has now verified the performance of the SEPT9 biomarker in blood samples from three cohorts of colonoscopy-verified individuals that identified CRC of all stages in 72%, 74%, and 69% of the samples, respectively. Controls were positive in 10%, 8%, and 11%, respectively. Prospective population-based studies are under way and commercial partners have been selected.
The success of many investigational drugs is dependent on matching treatments with the appropriate target populations, noted Daniel Chelsky, CSO at Caprion Proteomics, in his presentation. "Variability in response to therapy, both with regard to efficacy and to adverse events, is leading the pharmaceutical industry down the path of personalized medicine. Further pushing the process along are government and private insurance payers who are faced with expensive treatments that can help some but provide little benefit and possible harm to others."
One promising solution to the problem, he observed, is to identify predictive biomarkers of drug efficacy; circulating proteins that stratify patients into populations of likely responders and nonresponders to a proposed therapy. Finding such biomarkers has been challenging due to the complexity of human plasma—the sample of choice—and to the available technologies for detection and quantification of thousands of proteins.
"Based on the experience of over two dozen preclinical and clinical proteomic studies with pharmaceutical partners, an industrialized and productive approach to biomarker discovery and validation has been developed by Caprion." Dr. Chelsky stated.
On the path to personalized medicine, discovering biomarker candidates is not enough. The Caprion approach identifies proteins that predict drug efficacy or that stratify patients by stage and severity of disease through a well-controlled and industrialized mass spectrometry analysis of plasma samples, Dr. Chelsky added.
The process begins with uniform blood sample collection into tubes containing protease inhibitors. Plasma is depleted by antibody affinity of the high- and medium-abundance proteins that typically obscure biomarkers of interest. Isolated proteins from each sample are digested to peptides that are more accurately identified and quantified by a quadrupole time of flight mass spectrometer. Peptides are matched across all samples and compared for peak intensity in each cohort of patients.
Those peptides, which are differentially expressed, are targeted for fragmentation to generate the amino acid sequence that is matched to the parent protein. Peptides identifying the same protein are clustered and subjected to a consistency filter that requires all peptides from the same protein to show similar behavior in each patient.
In a study performed by Caprion for a pharmaceutical company, plasma samples were compared between patients with ovarian cancer and breast cancer, as well as with healthy control subjects. Of approximately 50,000 peptide ions tracked across the samples, 4,000 were found to be differentially expressed.
These peptides were used to determine the proteomic relationship between the patients by multidimensional scaling (MDS). Each cohort was found to be distinct from the perspective of plasma protein profiles. "Thus, not only can patients with disease be distinguished, but those with two related diseases can be separated as well," Dr. Chelsky observed.
A similar study involved the identification of circulating prostate cancer biomarkers. To determine whether markers could be found in spite of significant differences in sample acquisition, three groups of samples were compared—healthy control samples from a commercial supplier and two sample sets from different suppliers of patients with prostate cancer.
The three groups were analyzed and compared to find 3,569 peptides out of approximately 43,000 detected across the sample population that distinguished the two cancer groups from the healthy controls. These peptides were used to compare the patients by MDS analysis. The peptides that distinguished the two prostate cancer sample sets from the controls were found to significantly overlap and the combined cancer group separated well from the healthy controls in the MDS plot.
Peptides that separated each cancer group from the controls were sequenced to identify approximately 200 proteins in each comparison. "The interesting finding," Dr. Chelsky noted, "is that 141 of the proteins in each group were shared, demonstrating that the impact of collecting samples from different sources was relatively minor compared with the effect of the disease on the plasma proteome."
Each of the prostate cancer patient sample groups contained individuals with stage T2 (n=14) and stage T3 (n=10) prostate cancer. A bioinformatics software similar to MDS was used to compare the patients. Most patients at the two stages could be separated based on their plasma proteomic profiles.
"This indicates that protein expression in plasma is not limited to distinguishing disease, but can be applied to measuring the stage or severity of the disease. The implications of this finding are important to diagnosis and treatment, as well as for monitoring response to therapy," Dr. Chelsky concluded.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
LEWISTOWN - It was a good season on the basketball court for Mifflin County senior Hunter Wright.
Wright averaged a double-double with 13.3 points and 10.6 rebounds a game leading the Huskies to an 11-12 overall mark and a berth in the District 6 Class AAAA playoffs.
For his efforts, Wright is the 2014 Harry Rothrock/Dick Webber Award winner, presented Tuesday night at Mifflin County High School.
Article Photos
Sentinel photo by MATT STICKER
Hunter Wright was the winner of the Rothrock/Webber Award as the county's best boys basketball player.
"One of my goals this year was to come in, have a good season and maybe win an award or two and have the team win a district championship," Wright said. "We didn't get that so the award will have to do, I guess.
"I worked pretty hard in the offseason. Aaron (Gingrich) got on my case that I needed to be a little more physical, so I started running and getting in shape. I worked on my game and got a double-double this year and I'm pretty proud of it."
Wright, who is attending Shippensburg in the fall, scored double figures in 20 of 23 games this season, including 14 points in the playoff game against State College.
"I don't know if I'm going to play basketball or not. They want me to play, but I haven't decided on any of that yet," Wright said.
The first runnerup for the award was Curtis Jerzerick, with John Michael Maclay getting second runnerup.
"Dick and Aaron (Gingrich) said this is one of the best senior classes they've ever had, so I'm proud of that. I had a blast this year. It was awesome," Wright said. "I'm excited about how we played this year, especially in the Mid-Penn. We had some great wins and it was a fun season. Like I said, I had a blast."
The Harry Rothrock/Dick Webber Award is given out annually by Merf Radio to Mifflin County's top boys basketball player. The award is voted on by local sports media, including The Sentinel. The award is named after former Rothrock High School basketball coach Harry Rothrock and former Kishacoquillas High School coach Dick Webber.


text:
Popular Diets
Popular Articles
Top Stories
Recent Enteries
Some experts suggest that maintaining a healthy weight, eating five servings of fruits and vegetables per day, or drinking plenty of water could all rank as the single best thing a person can do for their health. Dr. Mike Evans, founder of the Health Design Lab at the Li Ka Shing Knowledge Institute, an Associate Professor of Family Medicine and Public Health at the University of Toronto and a staff physician at St. Michael's Hospital, would disagree.
According to Evans, the single best thing we can do to improve or maintain our health is to fit 30 minutes of exercise into each day. While this may not seem like a lot to some, the average adult in the United States spends five hours per day watching television or screens.
"Being sedentary is bad for your health," said Evans in the following video, featuring some very intriguing white board art. "TV is a chronic disease. [Researcher] Lennert Veerman found that people who spend six hours per day watching TV can expect to live five years less than active people."
To improve your health, Evans suggests limiting sedentary activities, like sitting and sleeping, to 23.5 hours per day. Evans believes that exercise is the most important form of preventative medicine. (more…)


text:
Estimated shipping is based on standard shipping rate inside contiguous United States. Your order total including shipping & taxes (NC) will be displayed later in checkout before submitting your order.
Shop all Vibrators at Adam & Eve Toys: You'll find over 500 Vibrators in all styles, shapes and sizes!
|See all Vibrators
Our Best Selling Vibrators
New Vibrators You Should Try
Small and Powerful Vibrators
Vibrators are the most popular female sex toy today. The meteoric rise of The Rabbit Vibrator has brought vibrators into everyday life. Beginners and experts alike love the versatile vibrator; with clit, g spot or remote control models there are vibrators for every occasion. We at Adam & Eve encourage you to explore and experience the joys of vibrators.
Vibrators are the most popular women's sex toy today. Reaching its height of recognition when Sex in the City devoted an entire episode to the amazing orgasms Rabbit Vibrators can induce. But Rabbits aren't the only vibrators out there – Adam & Eve carries a full range of vibrators including anal vibrators, bullets and eggs, Pocket Rockets, Discreet Vibrators and many, many more.
Vibrators have been around since the late 1800's and by the 1900's were sold as "Mother's Little Helper" to help "hysteria" and to help put a "flush" in the cheeks. By the mid 1920's the vibrators' true purpose was discovered when they appeared in "stag" films and suddenly became taboo and shameful. Because, you know, the female orgasm was not important. This taboo remained in place until the sexual revolution of the 1960's.
Since then vibrators have seen a huge rise in popularity and have evolved to include one for almost every occasion. Rabbit Vibrators continue to be the most popular model with their fluttering ears and penetrating shaft to delight your clit and pussy. The tingling sensations produced by this pleasure pal are perfect for those who prefer dual clit and vaginal stimulation. Combine this with extra features such as a rotating shaft filled with "pearls", G-Spot stimulator or being waterproof for fun in the shower, the Rabbit will quickly become your favorite "pet."
Clit vibrators are also hugely popular and can be used almost anywhere if you have the right model. Most clit vibrators are small (mini) and quiet and some come with wireless remotes so your lover can control when and the power of the vibrations you get. Many clit vibrators also fall into the Discreet Vibrator category as well, so they are easy to travel to with and you don't have to worry about someone knowing what you do in your private time. Pocket Rocket Vibrators are a great universal style of sex toy; you can use them to achieve orgasm or massage out muscle tension.
Wand Massagers are also great multi-tasking vibrators. These vibrator "Cadillacs" plug right into the wall socket and are perfect for relieving muscle pain or amazing orgasms. Every sex toy collection should have one Wand Massager and some the attachments for added pleasure.
If you haven't explored the vibrators available today, you will be surprised by the wide range and variety available at the Adam & Eve Adult Shop. While the classic, discreet, traditional models are still available for your erotic pleasure, there are those that resemble bulging, glistening erections, wildly textured toys, double-headed dynamos and playthings that don't resemble phalluses at all!
We also have easy ordering over the phone: 1.800.293.4654 (US and Canada Only)
International customers call: 001.919.644.1212
©Copyright 2016 PHE, Inc.™ All Rights Reserved Worldwide.
All persons depicted herein were at least 18 years of age at the time of photography:
18 U.S.C Section 2257 Compliance Notice
Material in compliance with the record keeping requirements of 18 U.S.C. 2257 and/or 2257A
Custodian of records: C. Davis, Director PHE, Inc. 302 Meadowland Dr., Hillsborough, NC 27278


text:
Ask Adella is the public page where anyone can submit questions to me and have them answered publically. In a way, this page is like my ongoing F.A.Q.! I always look forward to new questions and hope that I'm able to solve your problem. Please enjoy!
View Latest Answered Questions Here!


text:
I have an Exchange Server that needs more space on the system/boot
partition. It is a Dell server with hardward-based mirrored drives. I
want to replace both the mirrored drives with larger capacity drives.
Is there an easy way to ghost the drive. I'm a little nervous (probably
needlessly) about programs that let you take an online backup since it
seems like they alter the boot records in some way (i.e. Acronis
TrueImage or Symantec LiveStateRecovery).
Does anyone on have feedback on a good program to use or the best way to
do this?


text:
In their September 2008 issue, Teen Vogue gives a shout-out to Rupert in their horoscopes section. Check out the scan here, with thanks to Anne!
French film site, Allocine.fr, published a short interview they held with Rupert on the Half-Blood Prince set. You can read the (somewhat rough) translation below:
"Each film is a little different. Ron is more certain of himself here. He plays Quidditch, has a girlfriend...Some cool [new additions.] We filmed our scenes with Jessie Cave (Lavendar Brown) some weeks ago, notably the kissing scene. Without rehersals, actually: We just went for it! It was a bit intimidating since it is before a Quidditch match and so it was in front of plenty of people! It was embarrasing at first, we were both nervous but we [got used to it] and it went well... The couple Ron/Hermione, I was expecting a little while reading the seventh novel. But it's true that when we are confronted with this scene, it will be rather strange to film. We have a very fraternal relationship, so it will be bizarre. But we will do it, don't worry! (laughs)
Thanks to SS and Kait for the heads up!
Update: Thank you to Red from SnitchSeeker for letting us know about a new photo of Rupert they found from last month's British Grand Prix. View it here in our gallery!
Submitted by admin on Fri, 08/01/2008 - 12:03


text:
Whirlpool WOC54EC7AB 27" Electric Combination Black Wall Oven and Microwave
Store pickup
1 year parts and labor
Save Space in Your Kitchen with the Whirlpool 27" Electric Combination Black Wall Oven and Microwave The Whirlpool 27" Electric Combination Black Wall Oven and Microwave is a powerful cooking machine that can whip up family dinners or large Thanksgiving feasts. The dual-purpose functionality helps maximize space and opens up more room on your countertop. With 4.3 cubic feet of oven capacity and 1.4 cubic feet of microwave capacity, you'll have plenty of room to cook for large gatherings. You can make a multi-course meal in no time with this handy, combo appliance. The oven features two adjustable racks to accommodate everything from small roasts to large holiday hams. With AccuBake technology, the Whirlpool Combination Wall Oven and Microwave uses built-in temperature sensors to give you even, consistent heat throughout the oven. This combination microwave and oven makes cleaning easy. Simply take advantage of the SteamClean setting, which only requires 1 1/4 cups of water to get rid of oven spills without using harsh chemicals.
- The Whirlpool 27" Electric Combination Black Wall Oven and Microwave allows you to prepare multiple dishes simultaneously
- SteamClean option helps you clean up spills by just using water
- Hidden bake element makes it easier to keep the oven clean
- One-touch microwave controls make cooking even easier
- AccuBake temperature management system has built-in sensors to achieve even baking
- EasyView window allows you to monitor progress without opening the door
- Precise Clean system tracks self-clean cycles to determine when more cleaning is needed
- Approximate dimensions: 27"W x 26.38"D x 42.56"H
- One-year limited warranty
Specifications & Dimensions
Product Documentation
Owner's Manual - English (Warranty)
Product Warranty - English
More Like This
View Product
View Product
View Product
View Product


text:
Historic Sites
Every city has its own unique feel and vibe, which is determined by a number of things. The local historic sites are no doubt one of the largest contributing factors to the aura that surrounds a city. When in Naples, users recommend paying a visit to Teatro San Carlo, in the Airport - Nap area to get a feel for what truly makes up the city.
Palazzo Filomarino
The palace hails from the 15th century and features Gothic windows, Ogival arches, a courtyard, and lava stone gateways. Among the palace's former inhabitants: Benedetto Croce, a historian and scholar who in 1947 founded the Institute of Historical Studies, an organization that continues to use the residence. (081-551-7159)
Castel Nuovo (New Castle)
Built in the 13th century by Charles I of Anjou and completely reconstructed in the 15th century. The massive trapezoid-shaped building features an archway offset by cylindrical towers. Inside is an ornate courtyard, which includes the Apartment of the Viceroys, Room of the Barons, and the Palatine Chapel. (081-795-2003)
Teatro San Carlo
Built in 1737, this is Italy's largest opera house and Europe's oldest theatre still in operation. A fire completely destroyed the facility in 1816. However, reconstruction began less than a week later, resulting in a theatre of even greater proportions, as evidenced by the luxurious trappings and monolithic architecture that marks this landmark venue. (081-797-2111)
Palazzo Pignatelli di Monteleone
This 18th century palace is the former residence of Duke Camillo Pignatelli di Monteleone. The palace is noted for its striking façade and stately entrance portal, and is a good example of the period's architecture.
La guglia di San Domenico
Enormous Gothic spire was first built in the late 1200's and later underwent extensive modification in the mid-1700's.
La guglia dell' Immacolata
Standing in the midst of one of Naples' leading piazzas, this spire was built in the late 1740's and closely resembles the design of an obelisk.
Santa Chiara
Built in the early fourth century, this church sustained considerable damage during World War II. However, Santa Chiara has since undergone considerable repair. On-site museum contains numerous Roman and medieval artifacts. (081-552-6209)
Piazza Dante
Named for poet Dante Aligehri, this public square is among Naples's long cherished locations. Marked by Romanesque architecture and Gothic flourishes, the area dates back to the 1500's, with its signature landmark being a 1872 statue of Dante standing in the midst of the square.
Castel dell'Ovo
Castel dell'Ovo is a 2000 year-old castle that stands on the Isle of Megaris overlooking the Gulf of Naples. Most importantly, it is the landing site of the Greek settlers who founded Naples. The fortress has since changed hands numerous times, with residential stints by Normans, the French, Brazilians, and Spaniards, and has served as a venue for cultural and artistic events since 1997. (081-764-5688)
Build your own lists that you can easily reference or share stories with your friends.Login ×
Forgot login/password?
Don't have an account? Create Your Account!


text:
Is the Debian 6.0 "Squeeze" Release Upon Us?
The long anticipated and oft delayed Debian Squeeze just might be ready for release. Last year those in the know predicted that Squeeze could be ready by Christmas 2010. Well, that time period recently passed, but eagle eye Sid users have just seen another clue that Debian developers might be preparing for release.
Release critical bugs concerning the next release have been markedly decreasing in recent weeks with those of major concern dropping to its lowest numbers this release cycle. The total number of all bugs remains relatively high at 1555 (down from over 2600 this time last year), the real number of bugs affecting this release is down to just 84. This number reflects all bugs minus ignored bugs, bugs in packages not in testing, and bugs whose tags indicate not in testing. This number has been very low and decreasing since the beginning of the new year.
Comments are closed.
Copyright © 2016 FreeSoftNews - All Rights Reserved


text:
This matchup again?
It's another game between the Patriots and Jets, two teams who are as intimately familiar with each other as two squads can be.
If recent history is any indication, that familiarity favors the Pats. As Ben Volin retweeted from FantasyStartSit, New England has dominated the second matchup between the two teams each of the last few years:
Good stat RT @FantasyStartSit: @BenVolin Pats have destroyed Jets in their 2nd meeting over the past 3 seasons. wins by 30, 21, and 42 pts— Ben Volin (@BenVolin) October 16, 2013
So will history repeat itself in the form of another Pats blowout? Here are five bold predictions for the Pats-Jets matchup in Week 7.


text:
Breakfast and the Flower Show
Join fellow alumni as we indulge ourselves in the flavors and floral scents of England while learning about the international opportunities that Penn State Abington makes available to students. Register
Catered by Market Vendor, Molly Malloy's.
Special Guest Speakers
Paul Steinke '86, General Manager of the Market
Dolores Rafter Arevalo, Coordinator of International Affairs at Penn State AbingtonFee: $50 per person
Includes English breakfast and ticket to Flower Show which will be made available at registration on the day of the event.


text:
Best Wines Under 30
Talk about room to play—the question here is not how to find the best wines under $30, it's about how to pick from all the amazing finds in wines under $30! At this price point, you can have an out-and-out field day hopping from chateau to bodega to cantina to California ranch with your arms so full of bottles you'll have to hire a U-Haul to hold all the treasures you'll find.
Why? Think about it. It's a little bit of a no-man's land as far as price points go. The big spenders will gladly dole out $50, $100 or much more a pop for special bottles or curiosities of whim. But the rest of the world? We want everyday wines under $20 (or less) that are accessible and good, but not bank breakers. At $30, give or take, producers know that their audience is expecting something better than good, but also something that they might be more willing the shell out a little more for than the average, work-a-day wine. These aren't special occasion wines (although they very well could be!); they are "Yay! It's Friday!" wines. That reasonable kind of splurge that we're all generally happy to engage in on weekend night when we can really kick back and enjoy it.
Want some specifics? You've got it: In this category, Zinfandel lovers can rejoice! Many of California's greatest Zin producers, like Ridge and Seghesio, have some of their best wines at $30 and under, not to mention lusty Napa Cabs from producers like Hardin and Honig. And let's not forget the Super Tuscans, Piemontese Nebiolos, stellar Crianzas from Rioja, limpid Loire Valley Sancerres and Cab Francs, and… well, sheesh. We could go on and on. Instead, check out our ever-updating list of the best wines for under $30 for a treasure trove of (affordable) indulgences!
Don't forget to check out our selections...
Filtered Search:
Your search yielded no results.