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University Public Relations
1000 E University Ave
Dept. 3226, Bureau of Mines
Laramie, WY 82071
Phone: (307) 766-2379
Fax: (307) 766-6729
Email: firstname.lastname@example.com
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University Public Relations
Pete Simpson Jr. - 1993
Cast member, New York City production of Blue Man Group
Grandson of former Wyoming Governor Milward Simpson and a member of a family that has always been interested in theater, Pete Simpson Jr. began his performance career by participating in the Casper Troopers Drum and Bugle Corps as a drummer for eight years.
After completing a degree in English and theatre at UW, Simpson earned a master of fine arts in acting from the Denver Center Theatre Company's National Theatre Conservatory in 1996.
Immediately after his graduation, Simpson was hired as the newest addition to Blue Man Group, an avant garde-based ensemble that has grown to become a national and international sensation since its New York debut in 1991. Since then, Mr. Simpson has performed, trained, directed or organized for Blue Man Group for over eleven years in their Boston, New York, Chicago, Amsterdam (NL), Oberhausen (DE), Berlin (DE), and Stuttgart (DE) companies. Among many other contributions to the Blue Man Group project, Pete has appeared with the Blue Man on several international TV programs (in addition to Jay Leno and Craig Kilbourne in the U.S.) Pete has also toured with Blue Man internationally with such artists as David Bowie, Moby and Alicia Keyes, and has contributed music to Blue Man's "Audio" and "Complex" CD's , as well as to the soundtrack to the animated feature, "Robots."
In addition to Blue Man, he has also been screening original video work and performing stand-up at Caroline's on Broadway and other venues in New York. Simpson is also a veteran of such regional theaters as Williamstown Theater Festival, the Denver Center Theater, and others. He has also performed in New York and toured internationally with New York experimental theater luminaries Richard Foreman, Richard Maxwell, Young Jean Lee and the Wooster Group (opposite Willem Dafoe in "North Atlantic"). He has worked as a musical arranger and choreographer for Darko Tresnjak in productions for the Blue Light Theater Company, Westport Country Playhouse, and others. Pete has also appeared in roles on TV's Law and Order and Conan O'Brien.
As a percussionist, Simpson was involved in UW's percussion and symphonic band ensembles as well as The Colorado Wind Ensemble for many years and has conducted marching percussion music clinics for several high schools in the U.S. He also co-founded the New York-based band, The Petersons, who have been joined on stage by a number of wonderful artists (Robert Sean Leonard, James Naughton, Mike Doughty and Paul Newman among others).
He is married to Israeli-American costume designer, Naama Greenfield-Simpson, herself the daughter of notable Israeli painter, Yitzhak Greenfield.
Photo courtesy of UWyo magazine


text:
Calories in Spears
Wondering how many calories are in Spears?Manufactured by Wegmans
Kosher Dill, Reduced Sodium
-- Grade
0 Calories
Nutrition Facts
Serving Size 1 oz (28 g)
Per Serving % Daily Value*
Calories 0
Calories from Fat 0
Total Fat 0g 0%
Sodium 140mg 6%
Carbohydrates 1g 0%
Protein 0g
*Based on a 2000 calorie diet
Spears Calories and Health Benefits
Get Nutritional Facts and the Health Benefits for Spears
Related Foods & Categories
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(Vlasic) Stackers Kosher Dill - Reduced Sodium
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(Kroger) Value Dill Spears - Kosher
(Mt. Olive) Dill Spears - Kosher

subset: commoncrawl


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The Adams County SPCA reopened at noon Wednesday after closing earlier this month due to a potential virus outbreak.
Shelter officials euthanized one dog that tested positive for parvo virus, but the virus did not spread to other dogs.
Officials said all dogs in the shelter have been cleared and are healthy.
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remember last KCWC?).
This dress was high risk - no pattern and about 2 meters of fabric that I really, really like. The kind of fabric that I don't dare to use because I don't want to ruin it. But I guess when I am really tired I need something truly inspiring. Things made under similar circumstances have gone terribly wrong, but somehow this has turned out well. A little big maybe. But it won't be when summer arrives.
And while thanks to KCWC her summer wardrobe is slowly taking shape, the little one has inherited many old favourites. This one for example she has now worn 76 hours straight. Not sure if or how I'll get it into the washing machine.
Sunday, April 29, 2012
Friday, April 27, 2012
Maxi Smock
So I decided to adapt the pattern for a 5 year old. A maxi smock, so to speak. With the addition of a pocket or a hiding place for sweets. Unlike her sister she doesn't eat all of her favourite sweets in about 30sec. She wants to make them last. Which becomes quite a challenge when your little sister sees some more lying around and doesn't care who they belong to.
Thursday, April 26, 2012
Denim Dress
Looking at this dress I can't help but see prototype nº 2. It makes me think of possible amendments to the pattern and prototype nº 3 and maybe also nº 4. Maybe this will get me closer to what I had in mind. Sometimes it just takes me many, many steps. And every little step is a lesson learned and unfortunately, can't be skipped.
She likes it. And as she can never have too many dresses she doesn't mind me trying.
Wednesday, April 25, 2012
1 hour skirt
Which is why by the end of KCWC my kids have new summer clothes and a very tired mother.
But this skirt really does take no more than 1 hour.
+ Take hip to knee measurement (here: 36cm)
+ add seam allowance for sewing in elastic waistband (here: 6cm)
+ add seam allowance for bottom seam (here: 4cm)
+ cut rectangle of 140cm x 46cm
+ sew
+ done!
You probably think 140cm is a lot of fabric, but she wants her skirts to really 'fly'. If it doesn't 'fly' it's not a proper skirt. It's the first thing she checks when she tries one on. So they have to be big.
Tuesday, April 24, 2012
Tiny Pocket Sweater
Starting with something sensible – a sweater. With a tiny pocket.
The pocket to her is a bit pointless. Too small for her hand and "Why so far up?"
"But it looks nice", I say.
"Only because it looks nice?"
"And why the stripes at the bottom? Why not just a bigger strip of soft pink?"
But she did make a double using wire and paper and called her Anna. Anna turns out to be very good at modelling when my real daughter is busy playing.
Maybe Anna likes the pocket and the stripes.
Wednesday, April 18, 2012
Preparing for KCWC
The older they get the more they participate. At the moment, they are fascinated by the tape measure, measuring everything that comes their way. Did you know that a Haribo Gummibärchen measures 2.2 cm?
What's on your list of things to sew?
I doubt you'll be short of ideas, but just in case... some past KCWC creations.
Sunday, April 15, 2012
Sunday Mondays
Wishing everyone a Sunday kind of Monday... (maybe with your head in the clouds?)
Thursday, April 12, 2012
Sun Caps
1) to wear "X" (insert whatever extremely light and short item of clothing)
2) to not wear "Y" (insert whatever sensible item of clothing for temperatures below 30ºC)
Finally, my daily mantra 'It is too cold. You'll get a cold and then you have to stay in bed' is showing some effect. I have managed to establish some compromise (jackets on, but zipper closed only half way up). And now this. The sun is strong enough to burn their little pale noses. They have to wear a sun cap. But the jacket has to stay on!
I based the pattern on a Che Guevara style cap. To my surprise, even easier to make than last year's.
Tuesday, April 3, 2012
Spring jacket
They've been doing a cinema project at school watching and reenacting 'The Jungle Book'. As a big surprise (or present to her mom) she didn't choose to be the girl in the village, but one of the elephants.
Of course, a girl elephant with leggings and a jacket that could almost be a dress. And (very important!) a jacket with a hood to hide her long hair. Because Colonel Hathi has a tendency to just cut off long, unruly hair. Do you remember the elephant parade? I couldn't get enough of watching her practice her part. Too sweet.
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A LaPlace man was arrested on suspicion of robbing the Valero Corner Market in Destrehan at gunpoint early Tuesday, then forcing his friend to drive the getaway car, also at gunpoint, authorities said.
Dervol J. Zeno, 28, of 533 Fife St. in LaPlace, asked his friend to stop at the convenience store so he could buy a drink. After returning to the vehicle, Zeno told his friend that he had "just done a caper," according to authorities.
"He forced the cashier, at gunpoint, to give him money out of the register," said Sgt. Dwayne LaGrange, a spokesman with the St. Charles Parish Sherrif's Office. The cashier complied and Zeno fled.
Zeno returned to his friend's car in the parking lot and told him that he had just pulled off a robbery, LaGrange said.
The friend began to argue with Zeno over what he had done. Zeno then forced his friend to drive him home at gunpoint.
Once home, a physical altercation ensued between Zeno and his friend over the robbery, authorities said.
Zeno was booked with first-degree robbery, aggravated kidnapping, simple battery, aggravated battery, simple criminal damage and aggravated assault. He remains at the Nelson Coleman Correction Center. No bail is set.
No charges have been filed against the friend, who was not identified, LaGrange said.
Joy Hirdes can be reached at firstname.lastname@example.com or 985.652.0950.


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|Educational Videos, Lessons and Games for K-12 School Kids
Writing Skills
Here is a list of video lessons to learn and improve English essay writing skills, writing style and creative writing skills. Also watch the video lessons on English Grammar.
Online Videos & Lessons: (Reviewed by K-12 teachers)
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Monday, January 14, 2013
Children on a bus headed for Summerville Elementary School Thursday morning found two bullets on the floor of the bus, prompting a brief search of lockers and an investigation.
Dorchester School District 2 PIO Pat Raynor reported that a student informed the bus driver that there were two bullets on the floor at the back of the bus. The driver immediately retrieved the bullets and notified district officials. The bus had run a route earlier in the morning for Summerville High School, Raynor said.
District security officers working with the Summerville Police Department immediately conducted a security sweep at Summerville High School. The students who rode that bus were all questioned and a search was conducted that included their lockers and utilizing metal detectors. No weapons or ammunition were found, Raynor said.
As the investigation continued Thursday at Summerville Elementary and Summerville High School, the Principal at Summerville Elementary met again with the students that rode the bus where the bullet was found. One of those students did eventually admit to having the bullets on the bus, Raynor said.
The Summerville Police also questioned the student and will file a report.
The student will be recommended for disciplinary action, Raynor said.
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Pima County Boosts Solar Electricity Usage
Supes unanimously approve 11 new solar installations on county property
Supes unanimously approve 11 new solar installations on county property
Spring storm systems are delaying start, but dry fuels are still abundant
Move is trial to see if the utility can further use renewable energy.
Targeted officials voted in favor of El Conquistador Country Club purchase.
Desert Angels hope to build opportunities by sharing their decision-making process
Voters to decide on borrowing money for projects in 7 subject areas, including roads
Desert Angels put more than $6.8 million in start ups in 2014
Also, trip to Guaymas enhances trade relations with Mexican counterparts.
Last time the market indicator was this robust was as the market crashed
United Way adds volunteers to its assistance program for final push to file on time.
County budget has $23 million deficit, and some cuts could come from courts.
Plan would widen the road to six lanes east of downtown through Country Club Road
2014 Estimate shows population growth accelerating again after post-recession slowness.
Utility would pay about 20% less to residential customers for excess electricity generation.
The Friday Business Report features AZPM's Zac Ziegler and Inside Tucson Business Editor Thelma Grimes.
Metropia's maker came out of UA business incubator
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April 17, 2001
Hallmark Recordings
Rhythm & Blues, Motown, Pop-Soul, Soul, Deep Soul, AM Pop
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Album Review
The Foundations
were a multi-racial London soul band led by a former boxer from Trinidad,
Clem Curtis
, whose hard soul vocals made
The Foundations
sound unlike any other British group in the late '60s. Steered by producer and songwriter
Tony Macaulay
in the studio, the band scored two huge international hits with "Baby Now That I've Found You" and ""Build Me Up Buttercup," both of which are included here. Other highlights of this collection include two "almost" hits, "The Bad Bad Old Days" and ""Back on My Feet Again," and several credible soul covers, most notably a solid version of ""Knock on Wood." An exciting live band,
The Foundations
were much more than a mere pastiche of Motown styles, as this collection shows.
Steve Leggett, Rovi
Track Listing
Baby, Now That I've Found You
Build Me Up Buttercup
The Bad Bad Old Days
Back on My Feet Again
Born to Live, Born to Die
Any Old Time (You're Lonely and Sad)
You Can't Fool Me
Knock on Wood
Nobody Loves Me Like You
Sitting on the Dock of the Bay
New Direction
Let's Stay Together
Love You Now
Keep Loving You
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Choose the period
Today, the police arrived at my door, telling me my child had been caught vandalizing. A boy who looked about 15 hugged me and said, "Hey, mum". I'm only 26 years old and had never seen this boy in my life. FML
by Female / 01/22/2013 at 6:16pm / Australia (Victoria) / Kids
Today, I waited over 30 minutes in freezing cold weather for my bus. When it finally arrived, I went to get on board, but slipped and fell on the icy ground. The driver waited a whole 2 seconds before snorting, "Ain't nobody got time for this shit", closing the doors, and driving off. FML
by frozensolid / 01/24/2013 at 4:25pm / Canada (Manitoba) / Transportation
Today, my boyfriend was in the shower and his phone was buzzing with calls and texts. Concerned as his nan is in ICU, I picked it up to find he's been secretly sexting his ex-girlfriend. FML
by heartbroken / 01/23/2013 at 8:57am / Australia (New South Wales) / Intimacy
Today, my mom had the option of choosing anywhere in the world where we could go on vacation. We live in the USA and she chose to fly to Texas, rent an RV, and drive to Florida. Anywhere in the world. FML
by j_Lauren / 01/27/2013 at 11:48pm / United States / Holidays
Today, I discovered that my downstairs neighbor is running a business out of her apartment. Or I should say, her pimp is. FML
by Anonymous / 01/22/2013 at 8:33pm / United States (Arizona) / Miscellaneous
Today, at my cousin's birthday party, my grandma took me to one side, slipped me a pad, and started ranting that tampons "steal your virginity" and that I should never use them. Well, okay then. FML
by dynah114 / 01/27/2013 at 2:08pm / Israel (HaMerkaz) / Miscellaneous
Today, I dragged my boyfriend to see Les Misérables with me. He now refuses to communicate with me through any medium other than singing. Apparently, this is his revenge. FML
by lesson.learned / 01/21/2013 at 4:39pm / United Kingdom (West Sussex) / Love
Today, I was upset because my brother, who I'm very close to, didn't call me for my birthday yesterday. I told my mom about it, and we both immediately went silent on the phone, as we both realized she forgot to call me yesterday as well. FML
by birthday_loser / 01/23/2013 at 2:33pm / United States (Virginia) / Miscellaneous
Today, I made my first snowman ever, and then cried when my big brother kicked it to pieces. I'm 27. FML
by Anonymous / 01/23/2013 at 7:17pm / United Kingdom (Kent) / Miscellaneous
Today, I was driving my 9 month pregnant sister around in our golf cart and it died. I had to push it the rest of the way home. She wouldn't stop faking going into labor. FML
by really?!? / 01/25/2013 at 10:49am / United States (Massachusetts) / Miscellaneous
Today, while babysitting my neighbors' kids, their oldest son used a paint pen on the carpet. The boy blamed me and I got fired. He's only 3 and can barely talk. FML
by anonymous / 01/26/2013 at 3:42am / United States (Alaska) / Kids
Today, I have to take a midterm, which is worth a large part of my grade. All our teacher has taught us so far is how to roast s'mores over a Bunsen burner, and how to make gummy bears explode. Our test is on kinetics. FML
by Anonymous / 01/21/2013 at 4:26pm / United States (California) / Miscellaneous
Today, I got married. I'm Jewish, and it's traditional to break a glass cup by stepping on it after giving the bride her ring. My brother thought it would be funny to replace the glass cup with a rubber one. I slipped and fell flat on my back. FML
by Anonymous / 01/25/2013 at 3:13pm / Canada (Quebec) / Love


text:
CARMEL, Ind. — Rory McIlroy beat the strongest leaderboard in golf this year Sunday in the BMW Championship and joined some elite company.
McIlroy made back-to-back birdies around the turn to emerge from a four-way tie and seize control at Crooked Stick. He closed with a 5-under 67, making his only bogey on the final hole when it no longer mattered, for a two-shot victory over Phil Mickelson and Lee Westwood.
Everyone knew Boy Wonder was a special player when he won the U.S. Open last summer with a record score. The last month has established him as the dominant player in golf, with three wins in four tournaments loaded with the best players — the PGA Championship and two FedEx Cup playoff events.
McIlroy became the first player since Tiger Woods in 2009 to win in consecutive weeks on the PGA Tour, and with his sixth career win, he joined Woods and Jack Nicklaus as the only players to win at least six times at age 23.
"I didn't think everything would happen so quickly, but I'm on a good run at the minute and I want to keep it going as long as I can," McIlroy said.
McIlroy has four wins on tour this year — one more than Woods — and that includes a record eight-shot win at the PGA Championship.
Amarillo native Ryan Palmer shot a 1-over 73 finishing the tournament with a 3-under 285. Palmer tied for 45th overall.
Palmer entered the BMW ranked 57th in FedEx points and finished in 55th. He needed to reach the top 30 in FedEx points to qualify for the Tour Championship Sept. 20-23 in Atlanta.


text:
Max Zellweger, president of Columbia Winery, says the blue look will be traded in for a "warmer color."
Photo by Jeff Switzer/Woodinville Weekly.
by Jeff Switzer
The Columbia Winery is looking at mid-May for completion of their new banquet hall, additional production space, more parking, and remodeling.
The expansion adds 25,000 square feet, increasing the building by 33 percent: 12,000 square feet for production, 2,500 for office space, and the remainder for the meeting rooms, banquet areas, and kitchen.
The banquet hall will seat 250, and will feature a large outdoor patio and more greenspace for wedding receptions. A new smaller, more intimate gathering room will seat about 30.
In addition, a 10-foot bike and pedestrian trail around the outer edge of the property is being finished, connecting to Redhook Brewery's existing trail. Visitors will also notice the retail and tasting areas have been remodeled, adding a large oak tasting bar to match the existing oak paneling.
"This has been a very exciting process from the beginning," Zellweger said. "We all felt we needed to do something. The facility was not designed to handle the large number of visitors that come through here."
Zellweger added that the blue exterior will be traded in for a warmer color, as the blue "may be a little cold for the area." Painting is expected to begin within the next two weeks.
Zellweger's Associated Vintners, which owns Columbia Winery in Woodinville and Paul Thomas Winery in Sunnyside, purchased Covey Run Winery on Mar. 4, making Associated Vintners the third largest winery in the state.
Covey Run was founded in 1982 by farmers more associated with fruit orchards than grapes. "Covey Run brings a good mix to the wineries represented by Associated Vintners," said Simon Siegl, executive director of the Washington Wine Commission.
Currently, Stimson Lane--owners of Chateau Ste. Michelle, Columbia Crest, Domaine Ste. Michelle, Snoqualmie, and Whidbey Wineries--has the biggest piece of the pie with about 60 percent of the market, followed by The Hogue Cellars, which takes about 10 percent.
With the acquisition of Covey Run, Associated Vintners market share puts them at third largest in the state with about 6.6 percent.


text:
The Vampire Diaries
- Release date:10 September 2009 (USA)
- Genre:
- Summary:The Vampire Diaries is an American supernatural-fantasy horror television series developed by Kevin Williamson, based on the book series of the same name by L. J. Smith. The series follows the life of Elena Gilbert (Nina Dobrev), who falls in love with vampire brothers Stefan (Paul Wesley) and Damon Salvatore (Ian Somerhalder). The series also focuses on the lives of Elena's friends and other inhabitants of the fictional town of Mystic Falls, Virginia, including Bonnie the witch, Tyler the werewolf, and Caroline the vampire. The series is a mix of teen drama and the supernatural. [+]more
- External links:
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Episode Guide For The Vampire Diaries add new episode
- Episode 1 Hello, Brother 10/21/2016
- Episode 2 Today Will Be Different 10/28/2016
- Episode 3 You Decided I Was Worth Saving 11/4/2016
- Episode 1 Day One of Twenty-Two Thousand, Give or Take 10/8/2015
- Episode 2 Never Let Me Go 10/15/2015
- Episode 3 Age of Innocence 10/22/2015
- Episode 4 I Carry Your Heart With Me 10/29/2015
- Episode 5 Live Through This 11/5/2015
- Episode 6 Best Served Cold 11/12/2015
- Episode 7 Mommie Dearest 11/19/2015
- Episode 8 Hold Me, Thrill Me, Kiss Me 12/3/2015
- Episode 9 Cold as Ice 12/10/2015
- Episode 10 Hell Is Other People 1/29/2016
- Episode 11 Things We Lost in the Fire 2/5/2016
- Episode 12 Postcards from the Edge 2/12/2016
- Episode 13 This Woman's Work 2/19/2016
- Episode 14 Moonlight on the Bayou 2/26/2016
- Episode 15 I Would For You 3/4/2016
- Episode 16 Days of Future Past 4/1/2016
- Episode 17 I Went to the Woods 4/8/2016
- Episode 18 One Way or Another 4/15/2016
- Episode 19 Somebody That I Used to Know 4/22/2016
- Episode 20 Kill 'Em All 4/29/2016
- Episode 21 Requiem for a Dream 5/6/2016
- Episode 22 Gods & Monsters 5/13/2016
- Episode 1 I'll Remember 10/2/2014
- Episode 2 Yellow Ledbetter 10/9/2014
- Episode 3 Welcome to Paradise 10/16/2014
- Episode 4 Black Hole Sun 10/23/2014
- Episode 5 The World Has Turned and Left Me Here 10/30/2014
- Episode 6 The More You Ignore Me, The Closer I Get 11/6/2014
- Episode 7 Do You Remember The First Time? 11/13/2014
- Episode 8 Fade Into You 11/20/2014
- Episode 9 I Alone 12/4/2014
- Episode 10 Christmas Through Your Eyes 12/11/2014
- Episode 11 Woke Up With a Monster 1/22/2015
- Episode 12 Prayer For the Dying 1/29/2015
- Episode 13 The Day I Tried To Live 2/5/2015
- Episode 14 Stay 2/12/2015
- Episode 15 Let Her Go 2/19/2015
- Episode 16 The Downward Spiral 3/12/2015
- Episode 17 A Bird in a Gilded Cage 3/19/2015
- Episode 18 I Never Could Love Like That 4/16/2015
- Episode 19 Because 4/23/2015
- Episode 20 I'd Leave My Happy Home For You 4/30/2015
- Episode 21 I'll Wed You in the Golden Summertime 5/7/2015
- Episode 22 I'm Thinking Of You All The While 5/14/2015
- Episode 1 I Know What You Did Last Summer 10/3/2013
- Episode 2 True Lies 10/10/2013
- Episode 3 Original Sin 10/17/2013
- Episode 4 For Whom The Bell Tolls 10/24/2013
- Episode 5 Monster's Ball 10/31/2013
- Episode 6 Handle With Care 11/7/2013
- Episode 7 Death and the Maiden 11/14/2013
- Episode 8 Dead Man on Campus 11/21/2013
- Episode 9 The Cell 12/5/2013
- Episode 10 Fifty Shades of Grayson 12/12/2013
- Episode 11 500 Years of Solitude 1/23/2014
- Episode 12 The Devil Inside 1/30/2014
- Episode 13 Total Eclipse of the Heart 2/6/2014
- Episode 14 No Exit 2/27/2014
- Episode 15 Gone Girl 3/6/2014
- Episode 16 While You Were Sleeping 3/20/2014
- Episode 17 Rescue Me 3/27/2014
- Episode 18 Resident Evil 4/17/2014
- Episode 19 Man on Fire 4/24/2014
- Episode 20 What Lies Beneath 5/1/2014
- Episode 21 Promised Land 5/8/2014
- Episode 22 Home 5/15/2014
- Episode 0 Season 4 Preview
- Episode 1 Growing Pains 10/11/2012
- Episode 2 Memorial 10/18/2012
- Episode 3 The Rager 10/25/2012
- Episode 4 The Five 11/1/2012
- Episode 5 The Killer 11/8/2012
- Episode 6 We All Go a Little Mad Sometimes 11/15/2012
- Episode 7 My Brother's Keeper 11/29/2012
- Episode 8 We'll Always Have Bourbon Street 12/6/2012
- Episode 9 O Come, All Ye Faithful 12/13/2012
- Episode 10 After School Special 1/17/2013
- Episode 11 Catch Me If You Can 1/24/2013
- Episode 12 A View to a Kill 1/31/2013
- Episode 13 Into the Wild 2/7/2013
- Episode 14 Down the Rabbit Hole 2/14/2013
- Episode 15 Stand by Me 2/21/2013
- Episode 16 Bring It On 3/14/2013
- Episode 17 Because the Night 3/21/2013
- Episode 18 American Gothic 3/28/2013
- Episode 19 Pictures Of You 4/18/2013
- Episode 20 The Originals 4/25/2013
- Episode 21 She's Come Undone 5/2/2013
- Episode 22 The Walking Dead 5/9/2013
- Episode 23 Graduation 5/16/2013
- Episode 1 The Birthday 9/15/2011
- Episode 2 The Hybrid 9/22/2011
- Episode 3 The End of the Affair 9/29/2011
- Episode 4 Disturbing Behavior 10/6/2011
- Episode 5 The Reckoning 10/13/2011
- Episode 6 Smells Like Teen Spirit 10/20/2011
- Episode 7 Ghost World 10/27/2011
- Episode 8 Ordinary People 11/3/2011
- Episode 9 Homecoming 11/10/2011
- Episode 10 The New Deal 1/5/2012
- Episode 11 Our Town 1/12/2012
- Episode 12 The Ties That Bind 1/19/2012
- Episode 13 Bringing Out the Dead 2/2/2012
- Episode 14 Dangerous Liaisons 2/9/2012
- Episode 15 All My Children 2/16/2012
- Episode 16 1912 3/15/2012
- Episode 17 Break On Through 3/22/2012
- Episode 18 The Murder of One 3/29/2012
- Episode 19 Heart of Darkness 4/19/2012
- Episode 20 Do Not Go Gentle 4/26/2012
- Episode 21 Before Sunset 5/3/2012
- Episode 22 The Departed 5/10/2012
- Episode 1 The Return 9/9/2010
- Episode 2 Brave New World 9/16/2010
- Episode 3 Bad Moon Rising 9/23/2010
- Episode 4 Memory Lane 9/30/2010
- Episode 5 Kill Or Be Killed 10/7/2010
- Episode 6 Plan B 10/21/2010
- Episode 7 Masquerade 10/28/2010
- Episode 8 Rose 11/4/2010
- Episode 9 Katerina 11/11/2010
- Episode 10 The Sacrifice 12/2/2010
- Episode 11 By the Light of the Moon 12/9/2010
- Episode 12 The Descent 1/27/2011
- Episode 13 Daddy Issues 2/3/2011
- Episode 14 Crying Wolf 2/10/2011
- Episode 15 The Dinner Party 2/17/2011
- Episode 16 The House Guest 2/24/2011
- Episode 17 Know Thy Enemy 4/7/2011
- Episode 18 The Last Dance 4/14/2011
- Episode 19 Klaus 4/21/2011
- Episode 20 The Last Day 4/28/2011
- Episode 21 The Sun Also Rises 5/5/2011
- Episode 22 As I Lay Dying 5/12/2011
- Episode 1 Pilot 9/10/2009
- Episode 2 The Night of the Comet 9/17/2009
- Episode 3 Friday Night Bites 9/24/2009
- Episode 4 Family Ties 10/1/2009
- Episode 5 You're Undead To Me 10/8/2009
- Episode 6 Lost Girls 10/15/2009
- Episode 7 Haunted 10/29/2009
- Episode 8 162 Candles 11/5/2009
- Episode 9 History Repeating 11/12/2009
- Episode 10 The Turning Point 11/19/2009
- Episode 11 Bloodlines 1/21/2010
- Episode 12 Unpleasantville 1/28/2010
- Episode 13 Children of the Damned 2/4/2010
- Episode 14 Fool Me Once 2/11/2010
- Episode 15 A Few Good Men 3/25/2010
- Episode 16 There Goes the Neighborhood 4/1/2010
- Episode 17 Let the Right One In 4/8/2010
- Episode 18 Under Control 4/15/2010
- Episode 19 Miss Mystic Falls 4/22/2010
- Episode 20 Blood Brothers 4/29/2010
- Episode 21 Isobel 5/6/2010
- Episode 22 Founder's Day 5/13/2010
Latest News for The Vampire Diaries
- Comic-Con 2016: Biggest Hits and Misses From the TV Panels The dust has settled from Comic-Con 2016, and while Warner Bros. and Marvel's film divisions wowed the crowd with sneak peeks at the likes of "Wonder Woman," "Justice League," "Thor: Ragnarok" and "Spider-Man: Homecoming," the weekend wa... variety.com
- Sink Your Teeth Into These Juicy Details About The Vampire Diaries' Final Season The Vampire Diaries is on hiatus, but we already have a handful of details about what's coming up for the show's final season. While the season seven finale gave us a few clues about the fate of our favorite characters, creator Julie Plec and the case have already spilled a few details abo... popsugar.com
- What the Cast of The Vampire Diaries Has Said About the End of the Show Not ready to say goodbye to The Vampire Diaries yet? The cast feels your pain. After creator Julie Plec announced at Comic-Con that season eight would be the show's last, they rolled a video of the cast talking about what the show has meant to them. Once the lights went up again, the whole cast... popsugar.com
TVMuse Recommends
- report as inappropriate or spam tazy_pro 172 posts
Is Nina coming back for this season????!???1 months ago
- report as inappropriate or spam tazy_pro 172 posts
Officially caught up with this show now just patiently waiting for the new season to come out.1 months ago
- report as inappropriate or spam judgemenot 130 posts
I'm re-watching this series and I just realized how much I don't like Damon. Seriously, in season he was such a creep, and awful to everyone, especially Caroline and Stefan. And then he spent all season two trying to steal his brother's girlfriend. Seriously? And seeing how things are going to end I'm like dafug... like seriously? He's horrible, plus he slept with your mother Elena! Gawd, this blows. Seeing it the first time I was like... ohhh bad boy Damon, those eyes, man amazing, and now I'm like... no, no, no. It's just so wrong... no!2 months ago
- report as inappropriate or spam AlexB24-7 327 posts
It's official the cast of TVD announced at Comic Con today that season 8 will be the final season!!2 months ago
@AlexB24-7 ............... Ditto.4 months ago
"CW 2016-2017 schedule is officially announced at New York City Center at New York City on Thursday. The pronouncement revealed new shows to wait for, moved schedule and time."4 months ago
Program Schedule:
8:00-9:00 P.M. "Supergirl" (now on CW)
9:00-10:00 P.M. "Jane the Virgin"
8:00-9:00 P.M. "The Flash"
9:00-10:00 P.M. "No Tomorrow" (new show)
8:00-9:00 P.M. "Arrow"
9:00-10:00 P.M. "Frequency" (new show)
8:00-9:00 P.M. "DC's Legends of Tomorrow"
9:00-10:00 P.M. "Supernatural"
8:00-9:00 P.M. "The Vampire Diaries"
9:00-10:00 P.M. "Crazy Ex-Girlfriend"
iZombie, The 100, Reign, The Originals, and the brand new show Riverdale, will premiere in midseason.
- report as inappropriate or spam AlexB24-7 327 posts
I hope next season of the vampire diaries will be it's last. I am a huge fan of the show, but it's time to end it..since season 8 will be the last for Ian and Kat.4 months ago
@paigemontgomery1 ............ It isn't dude. Season 8 has been confirmed.4 months ago
this season i hope is the last, i already find it hard to want to watch right now. first nina leaves and now ian and kat are leaving? its time to move on i think4 months ago
- report as inappropriate or spam Graldine 191 posts
I like the Vampire diaries, but i really hope that the 8th season is going to be the last one.5 months ago
At least it already seems to be that way...Ian and Kat leaving after the 8th season.
It's time to move on if you ask me.
The 8th one might as well be their last season, with everyone leaving and all that.5 months ago
Kat Graham and Ian Somerhalder recently announced their departures after S8.
@Jani_ta ................... I reckon that aswel. I heard season 7 was the last (I can't recall where) but now it's been renewed for an 8th.6 months ago
- report as inappropriate or spam Jani_ta 21 posts
8th season is probably the last one.6 months ago
@iLoveNickandDisney .............. That's decent news dude.6 months ago
The Vampire Diaries has been renewed for an 8th Season.7 months ago
I Luv Fri .....TVD@Originals Wats Not 2Like Lol8 months ago
- report as inappropriate or spam Bourbon1 92 posts
This show has vampires, werewolves, and even witches. Where are the zombies?8 months ago
- Kalicka 120 posts
This comment is hidden because it's likely to be inappropriate or spam. Click here to show.9 months ago
- report as inappropriate or spam Bijou 1090 posts
Stopped watching after the finale for Season 4. Hearing some of the comments here saying Season 5 makes me question if I should catch up now that the seventh season has already started...9 months ago
TVD still, after seven years, holds my interest and viewership adamantly... and althought it will further detoriate, with all odds in regard, I do wish it to never desist. Once a fangirl, always a fangirl.. or oppositely referred as; whether you so are/happens to be : a fan"boy". ;) :P10 months ago
God I pray season 7 won't be the last... I can't bear the perception or image of it reaching closer to its ultimate finale'y(spelling error awareness!).
- "The only thing that has really changed in a shallow sense thought, if any thing, would be the depicted dynamic, especially since the kind of solo protagonist angle has been entirely removed from the picture." - which I must add, is rather likable. The mistake with TVD has always been that it only had Elena as a protagonist, when she isn't/weren't super interesting and when all the others characters evens out the story and makes up for all the thrilling action that narrates, which has been since season 1, nonetheless. :)10 months ago
Yeah... Despite Nina Dobrev's departure, I have to admit my presumption proved wrong. - The serie is yet entertaining; furthermore it's also quite intruiging and captivating on another level. But fundamentally the show hasn't changed the least, it still holds the same qualitative production bar rate as previously. The only thing that has really changed in a shallow sense thought, if any thing, would be the depicted dynamic, especially since the kind of solo protagonist angle has been entirely removed from the picture.10 months ago
On a side-note, about TVD not being an "adult"-rated tv-show, the only major thing with TVD to this day that still irks the crap outta me, is the actually deplorable love making scenes. Althought, I suppose most regular tv-shows are thoroughly more or less censured, but for some reason The Vampire Diaries is the only show I can think of that massively fails at it, perhaps because of the genres it's categorized among, instancely - romance, which is why you could easily conceive some certain ideas and consequently transpire into anticipation; and then, ultimately, if it doesn't signify enough, nor reflect that genre the least by embodied fulfillment - full on disappoint - like me in this instance! If actors aren't bothered by (which they aren't since they're intended to do their job, i.e. to be solely acting), so why should the producers be..? Like.. it truely baffles me. Since when are explicit love scenes labelled as damaging content in regards of the young viewers (scilicet : if there is any) and so sinfully unpalatable and condemnable to the minds of its distributors?? I can only arrive at the reasonable conclusion, that american's are for some inexplicable reason unnaturally prude by national customary/standardized upbringing, especially considering this show just as most I view, is of american origin.
Bascially when you hit the age of 15, you're yet very much immature, but no longer a child in the regards of sexuality. And my point being is, that since TVD is rated age 15+; it's fucking ludicrous to have it censured and inexplicit, because it most commonly withdraws the production quality once there is an actual love scene, althought seldomly. I know this bothered me since at least age 14, but I'm of Swedish origin and here nothing is exaggeratingly censured, thus I'm a living proof of an undamaged adult who witnessed sexual content as a child on very adult movies. Difference back then; such scenes didn't captivate me at all, because it was out of my apprehensive ability, just as it is for any and most children even of todays measures.--
- report as inappropriate or spam caitiegl 45 posts
I got half way through Season 5 and gave up. I occasionally check back in to read the descriptions and just find myself shaking my head and laughing at how ridiculous this show has gotten. Nina in it or not, its sharkjumped off a bloody cliff.10 months ago
I thought the first three seasons were pretty good, but then season 4 went downhill and by season 5 I was ready to give up. I didn't even finish the last few episodes of that season. Now that I see in comments Nina has left the show, I'm considering catching up. She was a big part of my annoyance.11 months ago
If you guys think that this show went downhill after Nina left you are mistaken. It has gotten better ever since! I myself am surprised!11 months ago
- IonutWarlam 3658 posts
This comment is hidden because it's likely to be inappropriate or spam. Click here to show.11 months ago
- report as inappropriate or spam EmelieS91 380 posts
Not watching without Elena12 months ago
- report as inappropriate or spam Kalicka 120 posts
Just finished re watching the first four seasons. I had to stop at episode 3 in season 5, what a terrible season. Season 6 wasn't much better, and not worth re watching either. Not having high hopes for season 7!1 years ago
Well at least Season 6 is so much better compared to Season 5.1 years ago
- report as inappropriate or spam rzr27 63 posts
@babes couldn't agree more1 years ago
- report as inappropriate or spam Betti 125 posts
anybody knows if Nina Dobrev Reunites With 'Vampire Diaries' Cast ??1 years ago
I love both actresses (Nina Dobrev and Victoria Justice). They do look alike, but not entirely, but I wouldn't recommend Justice for the show. She's better at comedy and not drama. Her acting was quite ridiculous in her show, "Eye Candy", which was cancelled after its 1st season. She should stick to comedy.1 years ago
However, Dobrev is good for drama, action, and horror, and every other genre except for comedy.
- report as inappropriate or spam Scrubbz 92 posts
Im glad Nina Dobrev is leaving the show. Her character was getting really played out. There is so many more people that are more interesting in this show and i feel like its going to go on for quite a bit longer. Michael Trevino leaving is a little bit of a downer but the show will be fine.1 years ago
- report as inappropriate or spam babes105 538 posts
It's sad I laugh now when I think about this show, because all I can think is how idiotic the producers are, if they do still manage to be allowed to have a season 7, I doubt the premiere will even get a million viewers. It makes me so sad they destroyed such an incredible show. Honestly, learn to say when enough is enough, because you've legit made tvd a joke.1 years ago
- report as inappropriate or spam bitchplz 454 posts
Nina dobrev and Victoria justice might kinda look alike in a way, but they act way differently. I don't even really like Victoria in eye candy. Nina is somehow a way better actress. Victoria was altho good in victorious. Overall I must say again Nina is a better actress when it comes to doing movies and noncomedic TV shows even tho she is good at everything actually. #byefelicia1 years ago
@JessicaForbes .......... Nobody knows yet dude it hasn't been announced.1 years ago
Okay. So I binge watched in the past 30 days...I watched all my other programmes too so it took me a while. I love it. I couldn't care less about Elena. I'm so looking forward to next season. When is it out?1 years ago
- report as inappropriate or spam Mariska 195 posts
I started watching this show on 2010 and will continue till the last episode. I know some of my favorite characters will die or leave the show...but who cares thats the way it is...nothing last forever. Its sad that Elena turned into a sleeping beauty but its kinda cool. Its time for TVD to hire Victoria Justice for the next doppelganger.1 years ago
- report as inappropriate or spam princesspyari 197 posts
There's one way they could have fixed that whole situation between Elena and Bonnie and it involves a little vamp blood and a broken neck on someone's part1 years ago
@JessicForbes yes you shud its really good1 years ago
- report as inappropriate or spam princesspyari 197 posts
This show lacks the action in the previous season. I hate the fact that they're focusing more on the drama, than the real action. You can't tell that the person who's directing this movie, is also directing The Originals.1 years ago
- report as inappropriate or spam dejay-1 30 posts
I feel like this is twilight no chick no show I don't think they can keep it going with those people and the new characters they bring in is not gonna cut it1 years ago
- report as inappropriate or spam MrOO7 1058 posts
Nina That Plays ( Elena ) left the show1 years ago
so if there will be next season we will never watch her at all
and its not just Elena , Her brother Geremy also left the show and Tyler to
Hmmm i wonder how this show will keep on going :(
I've binge watched. I'm on season 2 episode 10. So we've seen Elijah...I've already watched The Originals as I said so I know him...the Originals is just so much better than this. I do like some of the storylines but I already don't like the push pull of Elaina with Stefan & Damon. It's really odd...putting the vampire thing aside, Damon is a massive murderer who killed her brother & turned her birth mother. I'm not sure how one would get passed that. (This is just me assuming that this is what happens forever). I'm hoping the witchyness gets more interesting now & possibly the Wolves come out to play!1 years ago
- report as inappropriate or spam n_foreva8 390 posts
@JessicaForbes: The first three season are pretty good. After that it went downhill1 years ago
Should I give this a watch? I love Originals & I loved True Blood. Is this worth it?1 years ago
- report as inappropriate or spam IanCribb 288 posts
Isn't this around the time Nina dies in the books anyway? or did I read that wrong.1 years ago
Now its simple.Elena get that one single cure and gets compelled to just forget everything.1 years ago
- report as inappropriate or spam Graldine 191 posts
So i guess it wasnt a rumour..so sad..1 years ago
But even tough its sad she's leaving i am really really excited about how they will manage to keep the show going without her. Really wondering how that will turn out..:)
- report as inappropriate or spam dewdropvelvet 7828 posts
So sad about Nina.1 years ago
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A teenager is recovering after plunging through a skylight at a Massachusetts Institute of Technology fraternity in Boston late Wednesday night.
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SOLON, Ohio — Saturday night in Solon, it was the Conner Krizancic show.
Nevermind the fact that Mentor graduated a Mr. Football last year or that Krizancic is actually a commit to the University of Cincinnati as a wide receiver, Mentor coach Steve Trivisonno sees no reason why his quarterback shouldn't be in consideration for the state's top individual honor.
In Mentor's Division I, Region 1 quarterfinal Saturday against Stow, Krizancic passed for one touchdown and rushed for three more. Oh, and he had a touchdown reception of his own, his third of the season.
"He continues to impress," Trivisonno said.
Running back/wide receiver Eddie Daugherty, wide receiver Brandon Fritts and defensive back Mason McKenrick played strong supporting cast roles in Krizancic's stand-up show.
It took them all for Mentor to shut out Stow, 43-0, giving the Cardinals their fifth shutout of the season.
Mentor compiled 357 total yards of offense to Stow's 55 in the first half.
In the second quarter, Stow was able to pick off Krizancic once as Brian Groves ran it back 64 yards. Mentor's McKenrick intercepted it back two plays later.
"We're getting better at that," Trivisonno said about the Cardinals forcing turnovers. "I don't think we were very good at that early in the year. ... That's what's important in the playoffs."
With three seconds left in the second quarter, Trivisonno called a timeout and looked like he would call for a field goal. Instead, Krizancic marched back out with three to his right and one to his left. When the safety covered to the right, Krizancic knew he had one-on-one coverage to Fritts on the left. He aired out a 30-yard pass as time expired for a touchdown.
"My theory has always been we're going to play full out in the first half and if people don't like that, that's too bad," Trivisonno said. "Our kids, we owe that to the kids to play that way. We will always play that way and I would expect somebody to do that to us."
The Cardinals went into to the half up 40-0 with three picks, one fumble recovery and three sacks.
The second half started with Stow recovering the kickoff.
For the third consecutive week, Trivisonno was able to rest Krizancic after the first drive of the second half. Sophomore Matt Eiswerth took over for the second half.
"That's amazing for us because there's always a risk of injury," Krizancic said. "It's great to get us out and get younger guys some experience."
Mentor forced the Bulldogs to a three-and-out and then finished the next drive with a field goal.
That was the lone score of the third quarter.
Late in the fourth, junior Jake Floria also was put in the game as the band danced around to the chicken dance.
Neither team scored in the fourth.
The Cardinals' victory means they will face St. Ignatius next Saturday in the regional semifinals, which is a 2013 Week 2 rematch, which St. Ignatius won 26-6, and a postseason rematch from last year's epic regional final, which the Cardinals won 57-56 in triple-overtime.
"It's going to be a dogfight, like always," Fritts said.
In the 2012 regional final, eventual Mr. Football winner Mitch Trubisky, now at North Carolina, compiled 549 yards of offense and six touchdowns. He also threw the winning two-point conversion pass to Fritts, a North Carolina commit.
That game added to the strong case for Trubisky as Mr. Football and it could likely add to Krizancic's case too.
"I'm not worried about that at all right now," Krizancic said. "I'm just trying to win a state championship, and if awards come, awards come."
For now, everyone just needs to sit back and enjoy the upcoming show.
Contact high school sports reporter Stephanie Kuzydym by email (firstname.lastname@example.com) or on Twitter (@stephkuzy). Or log in and leave a message in the comments section below.


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There will be — how shall we put this? — an extra frisson when Germany take on Greece in the quarter-finals of the European Championship. The backdrop of the euro crisis, and the mutual sense of resentment that has been building in recent months, will provide an unavoidable political context when the whistle blows on Friday evening.
Greek anger at what they perceive as the intransigence of Germany, which has pushed for eye-watering public spending cuts in return for a bailout, is undeniable. "It's like going to a doctor with lung cancer and instead of helping you, he is telling you, 'Serves


text:
Prompting contributors to engage their own colonized otherness, the issue seeks contributions that will broaden our understanding of cultures of post-Communist societies through a variety of cultural and literary theories that proved to be of particular relevance to the study of the contemporary age (post-modernism, post-colonial theory, diaspora and globalisation.) The issue will attempt to rekindle the militant relevance and political involvement of cultural studies in the new context of postcommunist Europe from a range of perspectives that include (but are not limited to):
"h Marginalized cultures
"h Cultures of lies
"h Looking Westwards since 1989
"h Tradition, nostalgia and belated communism in post 1989 national identities
"h Cultural Diaspora and de-territorialization
"h Cultural contradictions of post-communism
"h Derridaˇ¦s Reflections on Post1989 Europe (The Other Heading)
"h Postcommunist literatures
"h The emergence of new linguistic and discursive paradigms
"h Postcommunism in translation
"h Postcommunism in the West: around Le retour de Marx
We welcome interdisciplinary approaches, ranging across critical theory, literary studies, cultural studies, general and applied linguistics as well as other disciplines in the humanities. Contributors are advised to follow the journal's submission guidelines and stylesheet. The deadline for article submissions is 15 April 2012. The articles should be sent to as attachments to: email@example.com. All submitted articles will be peer-reviewed. Accepted articles will be returned for post-review revisions by 1 May and are expected back in their final version by 7 May.


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H1N1 Vaccine Available
Residents of York City who are 24-years-old or younger can call 815-0910 for an appointment and receive the H1N1 vaccine at no cost from the York City Health Bureau. Those planning to get the free vaccine will need take some form of proof of residency with them such as a driver's license, photo I.D., or a utility bill.
The York State Health Center located at 1750 N. George Street is also offering the H1N1 vaccine. Students will need to call 771-4505 for an appointment. Vaccines are by appointment only on Wednesday, Dec. 2 and Thursday, Dec. 3 from from 2:00p.m. - 6:00pm.
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10 things about the Oscars
POSTED: 01:46 PM PST Jan 24, 2012 UPDATED: 10:00 PM PST Feb 26, 2014
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/ Home / Analysis Tools / Data Management
A global evaluation of microarray data warehouses
Contact:Sophie Lemoine ( firstname.lastname@example.com)
This evaluation was realised mainly in 2002 and directed by Olivier Alibert, on the CEA/Genopole
microarray platform (directed by Xavier Gidrol).
I-The need of criteria
To choose a database among these, you have to determine criteria depending on your lab, on the people you work with, on your goals... You first have to ask you the good questions. Here are the criteria we chose, just as an example :
II-A summary of the evaluation : the main points
Academic and commercial databases both exist. The academic databases are uselly free for a non profit use, what is a positive point ! The disadvantage is that you have to install it on your own, what can be discouraging if you have nobody to help. Commercial products can be very expensive (Resolver and Luminator), some are more reasonnable. It can be a good choice if you do not have anybody to take care of the database in you lab.
Both windows and linux databases exist : it depends on your equipements...
What kind of arrays do you use or plan to use ? Most of the databases can deal with cDNA arrays or affymetrix arrays. Some even deal with SAGE data.
Some databases are both local systems and public repositories. It can be an advantage if you want to export your data before publication. If your database is only a local installation, it may not be a problem for the exchange : it exists an exchange format, the MAGE-ML format, dedicated to the large-scale expression technologies that is becomming a standard. This format is the implementation of the MAGE project (MicroArray Gene Expression), supported by the MGED group. MAGE is an extended formalisation of the MIAME standard (Minimal Information About Microarray Experiment). Many databases adopt these new standards because the public repository and MIAME compliance are imposed by editors before publication, to ensure the validity of the experiment and the avaibility of the whole protocols and data.
III- The database home links and the complete evaluation table
Database home links :
The complete evaluation table (pdf file) :
Contact: Sophie Lemoine (firstname.lastname@example.com )
|This page is also available in french | Last page update: 9/7/2011 - 11:28
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text:
The prefrontal cortex (PFC) supports higher order cognitive functions, such as decision-making, reasoning, and working memory1. PFC functioning is impaired in cocaine addicts, which is manifest in their inability to make proper decisions when presented with challenges in their environment2,3. Genetic and environmental factors can influence PFC excitability4–6, and repeated cocaine alters the excitability of the PFC by biasing neurons towards strong inputs, such as those associated with drug cues, which may diminish cognitive function7. Understanding the mechanism underlying how PFC excitability influences the behavioral responses to psychostimulants is fundamental to learning how to reverse these maladaptive alterations in order to treat addiction.
Canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that play a crucial role in modulating neuronal excitability due to their involvement in intracellular Ca2+ regulation8. The TRPC5 isoform has been shown to play a role in dendritic growth and arborization through CaMKII-mediated mechanisms throughout the brain9,10, as well as the expression of fear conditioning in the amygdala11. TRPC5 channels a) are one of the two most prevalent TRPC channels in the adult rodent brain12; b) are densely expressed in deep layer pyramidal neurons of the PFC12; and c) modulate neuronal persistent activity necessary for working memory and attention13.
Since deep-layer pyramidal neurons of the PFC are known to project to limbic structures that subserve reward, such as the ventral tegmental area, nucleus accumbens, amygdala, laterodorsal tegmentum14, and the rostromedial tegmental nucleus15, TRPC5 channels may influence the ability of cortical networks to exert inhibitory control over these structures. Consequently, motivational and drug reward-seeking behaviors may be affected. In the present data sets, we gathered data from mice that lack functional TRPC5 channels in their forebrain CaMKII-expressing pyramidal neurons to measure their cocaine self-administration behavior as an index of cocaine reward.


text:
Carrots & Dirt Cupcakes {with chocolate covered strawberries}
So…. it would be a total lie to say that "spring has sprung."
Because it snowed yesterday. The entire day. Big, huge flakes. #ugh
At the rate we're going, it's going to be April and I'll still have my cute "Let it Snow!" snowman sign on my porch. I just don't feel like I can replace it with the springtime one… because that would just look weird with snow piled up around it. So I keep waiting and waiting and waiting… thinking that winter will be over any day. And each time it snows, I think, "A-ha! This is it. The very last snow of the year."
And then I'm wrong. Over and over again.
Since there's no garden planting going on right now (although, we're not planting one this year anyway– we're moving instead!)– I thought a cupcake garden full of chocolate covered strawberries (ahem, I mean carrots) would be just the thing to lift us out of our winter blues and get us ready for spring!
Yummy chocolate cupcakes covered in ganache and crushed Oreos and topped with a white chocolate covered strawberry. Looks like veggies, tastes like dessert. Works for me :)
Products I used in the making…
- 1 recipe Favorite Chocolate Cake, baked into cupcakes and cooled
- 1 recipe Chocolate Ganache
- 15 Oreos, crushed into fine crumbs
- 2 dozen strawberries
- 1 package Wilton's Orange Candy Melts
- Let cupcakes cool completely after baking. And allow ganache to cool just a bit, so that it is a similar consistency to hot fudge.
- Meanwhile, melt the candy melts according to the package directions. Dip each of the strawberries into the orange melted candy and place on a sheet of wax or parchment paper to cool and harden. Drizzle stripes across the top (I put some melted coating in a small bag and snipped the corner to make it easier to drizzle straight lines), and let cool and harden.
- Dip each cupcake into ganache and then immediately into the Oreo crumbs.
- Cut a small "slit" in the top of each cupcake. Insert the tip of a "carrot" strawberry into each cupcake.
Don't miss a bite!
Connect with Something Swanky:
Want more cupcakes? Pin these recipes!
More cupcakes from my friends:
Perfect Vanilla Cupcakes
Rocky Road Cupcakes
Salted Caramel Cupcakes
Latest posts by Ashton (see all)
- Flourless Chocolate Cake - September 26, 2016
- Pumpkin Cupcakes with Cream Cheese Frosting - September 23, 2016
- No Bake Pumpkin Cheesecake - September 21, 2016
20 Responses to "Carrots & Dirt Cupcakes {with chocolate covered strawberries}"
*sigh* these beautiful cupcakes will have to be enough for now.
…stupid snow.
YUMMY cupcakes!
These are the CUTEST CUPCAKES EVER!
These are as cute as can be. Creative and clever.
Linda@Tumbleweed Contessa
How many kids would turn down those carrots! Greatness … once again ;)
These look amazing! And perfect for Easter! Well done! Also I think you may be jinxing us with the whole "Let It Snow!" sign. You take down your snow man, and I'll take down the snowman pic in my entry way. Deal? We need to send Mother a message!
Adorable Ashton!! Pinned!
These are so cute!
This is my first time to visit your blog. Strawberries masquerading as carrots – brilliant!
Your pictures (especially the ones with cupcakes) are gorgeous!
These are so cute! I love that you made a strawberry into a corrot
These cupcakes are so stinking cute!!!
So cute and such a great idea to use strawberries. Love them!
These are adorable and so creative. It's snowing here again today. I'm so over it. Pinned.
This is such a clever idea, the strawberries look so cute as carrots! We just had to include this in our Feature Friday last week for 20 'Egg'stra Special Easter Desserts! Here is the link, I hope you can stop by: http://returntothetable.net/recipes/20-eggstra-special-easter-desserts/
I am looking to do these cupcakes for Easter and I was wondering one thing. What version of your Chocolate Ganache recipe did you use?
Hi – I'm thinking about making these for Easter this year. I just have one question. Can I make these a day in advance and refrigerate over night?
These are so creative!


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The Detroit Lions have parted ways with another draft pick, this time waiving linebacker Brandon Hepburn according to the Detroit Free Press.
Hepburn was selected in the seventh round out of Florida A&M. He's the second player from Detroit's 2013 draft class to lose his job Saturday, joining sixth-rounder Corey Fuller, a receiver out of Virginia Tech.
Detroit also cut its fifth-rounder (Chris Greenwood) from last year. Including last week's cut of fourth-rounder Ronnell Lewis, that's four draft picks from the past two years who are out as the Lions make their way to the 53-player limit.
They have until 6 p.m. to cut 15 more players.
Others who were cleared Saturday, as Detroit whittles its roster to 53 by the 6 p.m. deadline: Offensive lineman Kevin Haslam, linebacker Jon Morgan, offensive lineman Darren Keyton and safety Martavius Neloms (who was waived/injured after suffering a foot injury against Buffalo).


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Choose any three by three square of dates on a calendar page.
Circle any number on the top row, put a line through the other
numbers that are in the same row and column as your circled number.
Repeat this for a number of your choice from the second row. You
should now have just one number left on the bottom row, circle it.
Find the total for the three numbers circled. Compare this total
with the number in the centre of the square. What do you find? Can
you explain why this happens?
Take any two digit number, for example 58. What do you have to do to reverse the order of the digits? Can you find a rule for reversing the order of digits for any two digit number?
Can you explain how this card trick works?
Numbers are written by arranging digits in a row and each place
in the row has a different value. This value depends on the
base of the number system. The most common base
nowadays is 10:
We often use these short forms for the columns:
To count in different bases, we just group numbers in a
different way. For example, for base 2:
Zios count in base 3 so their numbers are grouped like this (we
shall only look at the first three columns):
Let's work out what a Zio's 111 is in human numbers (base
So, 111 = (1 x 9) + (1 x 3) + 1 = 13.
Zepts count in base 7 so their numbers are grouped like
Let's see what a Zept's 111 is in base 10:
So, 111 = (1 x 49) + (1 x 7) + 1 = 57.
To find out which way each type of creature is facing, calculate
each number in human counting (base 10).
Remember that the creatures must be seeing numbers which could
be a combination of Zios' and Zepts' legs.


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BIRMINGHAM, Ala. -- When Birmingham police burglary detectives got a report recently of a man selling thousands of dollars worth of locomotive batteries to a scrapyard, it automatically raised a red flag.
In years past, that curiosity might not have gone much farther than a few frustrating phone calls and a dead-end probe.
But police say a new online investigative tool has changed all that. With a few clicks of a computer mouse, detectives are solving more metal theft cases than ever before.
LeadsOnline, a nationwide program, lets officers search a database with millions of sales transactions from scrap metal recyclers each day to locate stolen metals.
The result, said Birmingham burglary Lt. Allen Treadaway, is a dramatic drop in property crimes that have long plagued the city. From January through June of this year, there has been a 17 percent decline in burglaries compared to the same time last year, and a 12 percent reduction in vehicle break-ins.
Police say would-be thieves are increasingly aware of the changes in enforcement, so the crimes are often deterred. Those who do bring in goods to scrap yards and pawn shops that are identified as stolen are often arrested and charged, police said.
"It's an incredible tool for law enforcement," Treadaway said.
Though crime has been on a decline nationwide and in Birmingham in recent years, property thefts -- including burglaries and car break-ins -- haven't really budged. Authorities say the poor economy has kept thieves hard at work.
About a year ago, Birmingham police officials stepped up their efforts in those areas, assigning a full-time detective to monitor pawns shops, and one to do the same at the city's vast number of scrapyards. To help them, they began to subscribe to LeadsOnline, which keeps a nationwide database of items sold to scrap metal recyclers, pawn shops and other places across all 50 states.
Brokers are required by state law or city ordinances to report their sales. When someone drops off items for sale, they must show their personal information.
The records are uploaded every day, and automatically available to law enforcement officers whose agencies subscribe to the service for a fee.
As a result, police officers can search the database by name, license plate, telephone number and other identifying information.
The locomotive battery sales in May caught the attention of detectives. They entered the name of the man who had sold the batteries in LeadsOnline, and were amazed at what they found.
"He had been selling an enormous amount of batteries over a short period of time," Treadaway said.
Further investigation showed he was employed by a Birmingham-based battery company. Detectives determined he and another employee worked in tandem to sell more than 10,000 pounds of locomotive batteries worth an estimated $150,000.
Darius Driver, 35, and Phillip Harris, 39, have been charged with first-degree theft. They are awaiting trial.
Just last month, Det. Justin Howard said detectives were interviewing a suspect about stolen car batteries taken from a local business. They ran the suspect's name through LeadsOnline, which showed evidence that he had sold the batteries the morning after they were stolen.
When confronted with the evidence they got from the computer search, he confessed to multiple counts of theft.
Because of the additional manpower and because of LeadsOnline, Birmingham police say they have cleared more than 100 metal theft cases that might have otherwise gone unsolved. Treadaway said they have seen a dramatic drop in the copper thefts from area businesses and churches, as well as utility companies.
"In our first two months of using LeadsOnline, we found more than 75 metal theft suspects who were victimizing the community with their crimes," Treadaway said.
Without the investigative power of the computer program, he said, "these criminals would have continued their destruction in Birmingham and across the state of Alabama."
Birmingham began using LeadsOnline about a year ago, and police Chief A.C. Roper said he knew the skill-set would benefit the department in fighting the issue of property crime.
"Implementing this program along with reallocating more personnel has made a tremendous difference across the entire city," Roper said. "We always see good results when our business owners and citizens work with us."
Join the conversation by clicking to comment or email Carol Robinson at firstname.lastname@example.com.


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Full CoverageBreaking News
Police questioning 2 men in attack on Langston University campusUPDATED 5:33 PM CDT Aug 08, 2013
Police are questioning two men who they say robbed three female students at a housing unit on the Langston University campus.Video Transcript
MEN WHO THEY SAY ROBBED THREE FEMALES STUDENTS AT A HOUSING UNIT AT LANGSTON UNIVERSITY. THEY SAY THESE TWO MEN HELD FEMALE STUDENTS IN A ROOM ON CAMPUS. KOCO'S NAVEEN DHALIWAL IS LIVE WITH DETAILS. NAVEEN BOTH MEN TURNED THEMSELVES IN THIS AFTERNOON. THAT'S AFTER TWO WEEKS OF BEING ON the RUN. NOW POLICE ARE HOPING SAY THEY LEARN THEIR MOTIVE. Clip 9 Sheree Perry - Student 37:30 its beautiful, it's safe. I love Langston University. I have no complaints. THAT'S HOW MOST STUDENTS DECRIBE LANGSTON UNIVERSITY .....A SAFE PLACE. BUT TWO WEEKS AGO AT THIS HOUSING COMPLEX CALLED THE COMMONS....THAT PEACE WAS DISTURBED. CAMPUS POLICE SAY THESE TWO MEN HUNTER GRIFFEN AND ADRIAN HINDS ARE BEHIND A VIOLENT ATTACK INSIDE AN APARTMENT. OFFICERS SAY ONE OF THE MEN HAD A GUN ....AND POINTED IT TO THE HEAD OF ONE OF THREE GIRLS INSIDE. CLIP 9 37:56 I'm shocked to hear that. Clip 4 Raymonda Grey - Student 35:05 it's pretty scary because I have kids, especially in the commons. POLICE SAY THE MEN THEN LOCKED THE GIRLS IN A ROOM AND TOOK OFF. AUTHORITIES SAY THE GRIFFIN AND HINDS ARE FORMER STUDENTS AND KNEW THE GIRLS. THAT HAS SOME STUDENTS RETHINKING THAT SAFE FEELING THEY'VE HAD ON CAMPUS. CLIP 9 37:48 I feel so safe here, I leave my door unlockedI don't think I can anymore. 53 AGAIN THESE TWO MEN ARE BEING QUESTIONED RIGHT NOW ....NOT ARRESTED YET. IN THE STUDIO. I'M NAVEEN DHALIWAL .....Back TO YOU. UNIVERSITY POLICE SAY THIS IS SO FAR AN ISOLATED INCIDENT. FSBULLETSVO
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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first two: his first day. Last: 6 weeks.
Meet Arlo Rollie Sasser. Born May 24th, 8:43 am 7lbs, 11 oz 20 and 3/4 inches long. Named for both our grandfathers, Marlow (mine) and Roland (his).
Arlo was born after a long time waiting. 60 hours of labor. I won't go into the whole birth story, but he was off center, his hand up to his face and posterior. My natural birth plan was in effect for almost 12 hours at the hospital, until I found out his position and after having intense contractions 30 seconds apart for 8 hours, and only progressing 2 cm, I was exhausted. I had the relief of an epidural which helped me to rest as it took 9 more hours until he was born. I had the most amazing support of Tyler and my doula, who were there for every second doing anything I needed.
After all was said and done, I am so happy with the way his birth went, and everything I did helped him to be born happy and healthy. He was born with the most shocking long white hair, the most pink/red skin, a heart shaped stork bite in between his eyes, and one left dimple.
He's the happiest of babies, with an easy temperament and lots of smiles to give. He makes me melt. Putting him to sleep in my arms is now my greatest of achievements.
It's been nice to have a few months to heal, adjust, and have him meet family. Now we are starting to settle into a routine, and I'm back from my self-induced maternity leave. Thanks for all the support.
10 comments:
What a beautiful little peanut. Congratulations to you and your husband, and enjoy every moment with your lovely son. (Great name, too!)ReplyDelete
congratulations, so excited for you!!ReplyDelete
he's beautiful Kenzie! such a sweet face. congrats again to you! {love the middle name Rollie btw. so cute}ReplyDelete
he's so darling. and i love his full name (and the meaning behind it)! hope you've been adjusting well -- i'm still working on it!ReplyDelete
Congratulations Kenzie!! What a beautiful baby :)ReplyDelete
I never tire of looking at pictures of him. What sweetheart!ReplyDelete
You've got a beautiful baby there. He looks especially thoughtful in that last photo. Congratulations and glad to hear you had a good birthing experience.ReplyDelete
Arlo is wonderful!ReplyDelete
He's so beautiful, and it's lovely to see the almost newborn pic alongside his much older and wiser self :-)ReplyDelete
Adorable name, adorable baby. Congrats.ReplyDelete


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Technical Support for the Healthcare Industry
Gone are the days where healthcare facilities could consist of staff members dawning white coats, nursing caps, and clipboards. Now, in addition to their stethoscopes and scrubs, they need certain technological advancements in order to stay in tuned with their patients growing medical needs. This is not to say the common cold needs a computer to cure it, but it does need software to track the symptoms.
Electronic Healthcare Records (EHR):
Electronic healthcare records have become the cornerstone for the healthcare industry, and for good reason. Not only are these their patient's official medical records, but they are easily transferred from one medical facility to the next. This is where healthcare IT with Versatile Networks comes into play, though. If a doctor is unable to access a patient's EHR this not only causes the doctor frustration, but it causes stress to the patient waiting next to them as well.… Continue reading


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PLAINSBORO — Alec Haase's day yesterday was much like that of the entire Hopewell Valley High football team's offense — a lot of inartistic, workmanlike grinding, but with a great payoff to show for it in the end.
Haase's first eight rushing attempts each went for two yards or less. But he still scored a career-high four touchdowns, including one on a 39-yard scamper early in the fourth quarter that pretty much sealed the Bulldogs' 28-7 win over West Windsor-Plainsboro North in West Jersey Football League action.
"The touchdowns will have my name in the stat book, but that was all the (offensive) line," said Haase. "On three goal-line stands, the line pushed me right in, and I just followed them in.
"Today, we didn't really click at a certain point. We just had big plays come up, and we finished."
The Bulldogs (2-0) finished the game with only five first downs, and didn't have a scoring drive that started in their own territory. Two of their touchdowns were set up by a fumble recovery and a low snap on a WW-P North punt, and one was set up by a long punt return and a 31-yard pass from Austin Fellows to Mark Wenner. Their final score was set up by a 75-yard pass from Fellows to Chaz Bell.
Despite scoring 28 points, Hopewell Valley amassed only 215 yards of offense.
"Today, I expected a little more out of our offensive running game, and we didn't get it," Hopewell Valley head coach Dave Caldwell said. "But what we did do is we stuck to the game plan. We kept grinding it and grinding it, and eventually one broke."
Playing a WW-P North team (0-2) that lost its starting quarterback to injury the week before, the Bulldogs' defense came within one big play of posting a shutout. That play — a 69-yard touchdown pass from Jack O'Connell to Darrien Banks against a Hopewell Valley blitz — came early in the fourth quarter after the game was essentially decided.
The Bulldogs struggled some against the Knights' running game early but made just enough plays to keep them from threatening to score. WW-P North finished with 213 yards of offense.
Neither offense ran a play in the other team's territory until Bell's 21-yard punt return put the Bulldogs at the WW-P North 39 with just over three minutes left in the first half.
Fellows hooked up with Wenner for 31 yards on the next play, and the Bulldogs were in the end zone two plays after that on Haase's first touchdown.
A low snap on a punt and a fumble by WW-P North led to two Hopewell Valley touchdowns in 61 seconds spanning the third and fourth quarters and a 21-0 lead.


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- When should I have a make up and/or hair trial?
- Do I have to go through a trial before I book with MIXX?
- Why should I hire a Make Up Artist for my wedding day?
- How long will my makeup last?
- How long will it take to apply the makeup on the day of?
- Do you provide mobile services?
- How should I prepare my skin?
- What types of products do you use?
- Do you offer makeup for all skin tones?
- How do I reorder a custom created MIXX product?
- Are the contents of the MIXX Pro Kit the only products available?
- After I purchase my KIT, how will I learn to create my own shades?
- What is my earning potential for purchasing a KIT?
Q: When should I have a make up and/or hair trial?
A: The sooner the better, that way you ensure the makeup/hair artist is reserved for your wedding day, and have one less thing on your "to do" list.
Q: Do I have to go through a trial before I book with MIXX?
A: Many MIXX brides who feel more comfortable securing their date first can do so. A 20% non-refundable deposit is required to secure the artist and/or stylist.
Q: Why should I hire a Make Up Artist for my wedding day?
A: We are professionals that know how to apply the right products to make sure you look flawless both in person and on camera. At MIXX we listen and provide the look to compliment you as well as the feel of your wedding. Plus the bride should be pampered on her special day.
Q: How long will my makeup last?
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Q: How long will it take to apply the makeup on the day of?
A: The makeup for the bride usually takes 40 minutes. The rest of the party are 30 minutes each, add 5 minutes for faux lash application. In general, hair is 45 – 1hour for the bride, approximately 40 minutes for the rest of the party. (depending on styles) At MIXX we will assist with setting timing goals and always arrive 15 minutes before start time.
Q: Do you provide mobile services?
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Q: Do you offer makeup for all skin tones?
A: Yes, we have a great deal of professional experience with all ethnic skin tones.
MIXX Cosmetics FAQ's
Q: How do I reorder a custom created MIXX product?
A: With every personal shade creation, MIXX builds your client profile with all blends created for you. All formulas are kept on file and can either be picked up at our studio once we are notified to replicate, or can be mailed out to you for a small shipping fee.
MIXX Pro FAQ's
Q: Are the contents of the MIXX Pro Kit the only products available?
A: The KIT includes the best and most sought after shades and tones. Each month MIXX features a new product that will add to your artistry, and possibilities of creating new colours and shades, As a Pro Mixologist, you will be sent monthly updates on new releases.
Q: After I purchase my KIT, how will I learn to create my own shades?
A: With each purchase of a MIXX Pro Kit, you will be welcomed to join our mixology workshop. We will demonstrate all the possibilities the KIT brings to your MUA profession. It will include how to MIXX the products, fill, selling techniques, options for marketing material as well as sanitary requirements.
Q: What is my earning potential for purchasing a KIT?
A: Please contact MIXX directly. You will be provided with a MIXX Pro info package that outlines all profitability and retail pricing on products you sell.


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Author Affiliations: Department of Neurology, St Josef-Hospital, Ruhr-University Bochum, Bochum, Germany (Drs Ayzenberg, Kleiter, Schröder, Hellwig, Chan, and Gold); and Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan (Dr Yamamura).
Objective To report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica (NMO).
Design Retrospective case series.
Setting Neurology department at a tertiary referral center.
Patients Patients with an aggressive course of NMO switched to tocilizumab after failure of anti-CD20 therapy.
Main Outcome Measures Annualized relapse rate and disability progression measured by the Expanded Disability Status Scale.
Results We report 3 female patients with a median age of 39 years (range, 26-40 years) and aquaporin 4–positive NMO. All patients had been treated with different immunosuppressive and immunomodulating agents, followed by 1 to 3 cycles of rituximab. Despite complete CD20-cell depletion during rituximab therapy, the median annualized relapse rate was 3.0 (range, 2.3-3.0) and the median Expanded Disability Status Scale score increased from 5.0 (range, 4.5-7.0) to 6.5 (range, 5.0-7.0). After the switch to tocilizumab (median duration of therapy, 18 months), the median annualized relapse rate decreased to 0.6 (range, 0-1.3). A total of 2 relapses occurred; however, they were mild and there were no changes in clinical disability.
Conclusions Interleukin 6 receptor–blocking therapy can be effective in therapy-resistant cases of NMO. Larger controlled studies are needed to confirm the efficacy of tocilizumab.
Neuromyelitis optica (NMO) is a rare, severely disabling autoimmune disease, preferentially affecting optic nerves and the spinal cord, structures highly expressing the target antigen aquaporin 4 (AQP4). Because of the severity of NMO attacks, prophylactic therapy must be started as soon as possible. Therapy response in NMO differs from that in multiple sclerosis; immunomodulatory medications (interferon beta and glatiramer acetate) seem to be not effective and natalizumab appears to even exacerbate disease activity.1,2 Several small studies and case report series demonstrated moderate efficacy of a number of immunosuppressive agents.3 More promising results have been shown for B cell–depleting therapy, yet approximately 20% of patients experience relapses despite the complete depletion of B cells.4- 6
Recently, specific AQP4-secreting plasmablasts exhibiting a CD19intCD27high CD38highCD180− phenotype have been described in NMO.7 Secretion of AQP4 antibodies by these cells is dependent on interleukin 6 (IL-6), a cytokine also known to be increased in NMO relapses.7,8 To evaluate if the IL-6 receptor–blocking antibody tocilizumab (ACTEMRA) could be a new therapeutic option for NMO, we analyzed the clinical course of 3 patients who were switched to tocilizumab after ongoing aggressive disease despite rituximab therapy.
Patients were identified from a cohort of 18 patients with confirmed NMO treated at a tertiary referral center. We searched for patients with aggressive disease who did not respond to rituximab therapy and had been switched to tocilizumab thereafter. Annual relapse rate and progression of disability, scored by the Expanded Disability Status Scale (EDSS), before and during rituximab and tocilizumab treatment were analyzed. Routine brain and spinal cord magnetic resonance imaging was evaluated for contrast-enhancing new or enlarged lesions before and during both therapies.
The presented 3 patients were treated on an individual basis according to internal recommendations. All data were analyzed retrospectively from patient files. All patients gave written informed consent for publication.
Three female patients were diagnosed with AQP4 antibody–positive NMO (Table). All patients had longitudinal spinal cord lesions (>3 segments) and a history of optic neuritis and transverse myelitis. No intrathecal immunoglobulin synthesis or oligoclonal bands were in the cerebrospinal fluid of any of the 3 patients. No patient had concomitant autoimmune diseases. Previous long-term therapies included interferon beta-1a and 1b (n = 2), glatiramer acetate (n = 1), azathioprine (n = 1), and mitoxantrone hydrochloride (n = 1). All patients had experienced pronounced disease activity (median, 13 relapses; range, 4-16; median annualized relapse rate, 2.6; range, 1.7-2.7; median EDSS score, 5.0; range, 4.5-7.0) prior to receiving rituximab. The median disease duration at initiation of rituximab was 8.2 years (range, 2.5-9.4 years) and the median age was 39 years (range, 26-40 years).
Rituximab was administered at a dose of 2000 mg/cycle (1000 mg + 1000 mg, patient 1) or 1500 mg/cycle (500 mg + 1000 mg, patients 2 and 3), with a 2-week interval between infusions. Patients 1 to 3 received rituximab for 32 (3 cycles), 8 (1 cycle), and 4 (1 cycle) months, respectively. Despite complete CD20-cell depletion, patients continued to experience relapses (median, 2; range, 1-6), with at least 1 severe relapse, defined by an EDSS score progression of 1.0 or more; the median annualized relapse rate was 3.0 (range, 2.3-3.0) (Table and Figure). Interestingly, in 2 patients, relapses occurred shortly after the first application of rituximab (after 18 and 40 days). Magnetic resonance imaging confirmed acute gadolinium-enhancing spinal lesions in patients 1 and 3. The clinical disability progressed in patients 1 and 2 by 1.5 and 0.5 points, respectively, and remained unchanged, with an EDSS score of 7.0, in patient 3.
Figure. Relapses before and during treatment with rituximab and tocilizumab. Shown are all relapses from month −72 to +21 (patient 1), +18 (patient 2), and +9 (patient 3), relative to the start of tocilizumab treatment. Bars depict duration of rituximab and tocilizumab treatment. In patient 3, disease manifested 31 months prior to the start of tocilizumab treatment.
Because of ongoing disease activity, patients were further switched to the anti–IL-6 receptor antibody tocilizumab. Tocilizumab was administered at a dose of 6 mg/kg every 6 weeks in patients 1 and 2 and every 4 weeks in patient 3. Duration of tocilizumab therapy was 21, 18, and 9 months in patients 1 to 3, respectively. Patient 2 was relapse-free and demonstrated improvement of her gait and EDSS score from 5.0 to 4.0 (Table and Figure). Two patients experienced a mild relapse without EDSS score progression, clinically presenting as isolated optic neuritis in patient 1 and moderate progression of the preexisting motor deficit in patient 3. The relapses occurred 3 and 4 months after tocilizumab treatment initiation, respectively. In both cases, deficits were reversible after receiving steroid pulse therapy. After the therapy regimen in patient 1 had been changed from every 6 to every 4 weeks, she was stable for the next 18 months. Compared with rituximab therapy, the median annualized relapse rate decreased from 3.0 (range, 2.3-3.0) to 0.6 (range, 0-1.3). Tocilizumab therapy was ongoing in all 3 patients.
Tocilizumab was well tolerated. There was no serious infection, malignancy, hypersensitivity reaction, or elevation of transaminase levels. Patient 3 experienced urinary tract infection in the fourth month and mild oral mucosis in the seventh month of therapy. Cholesterol levels had been elevated in patients 1 and 3 prior to tocilizumab therapy and demonstrated no significant increase after therapy initiation.
In this case series, we demonstrated the efficacy of the anti–IL-6 receptor antibody tocilizumab in rituximab-refractory, aggressive cases of NMO. The exact mechanism of action of rituximab in NMO remains unknown. Despite complete depletion of CD20+ B cells, it spares CD20-negative plasma cells and has only moderate and probably indirect effects on antibody production.5,6 Other rituximab effects include monocyte activation and increased synthesis of B-cell activating factor, a key molecule supporting differentiation and survival of B cells as well as immunoglobulin production.6,9 In line with this, an early transient increase of AQP4 antibodies after rituximab application has been reported.10 Notably, in 2 of our patients, relapses occurred early after rituximab initiation.
Inhibition of CD20-negative plasmablasts, which produce pathogenic AQP4 antibodies, might be an alternative treatment strategy. In the presented cases, a switch to tocilizumab led to definite clinical improvement. Recently, another patient successfully treated with tocilizumab was reported by Araki et al.11 They demonstrated a substantial reduction of the frequency of CD19intCD27highCD38highCD18− plasmablasts and titer of anti-AQP4 antibodies within 1 month after tocilizumab initiation. Similarly, tocilizumab decreased the frequency of CD27highCD38highIgD− plasmablasts and the titer of anti–double-stranded DNA antibodies in systemic lupus erythematosus as well as titers of rheumatoid factor in patients with rheumatoid arthritis.12
Despite overall clinical stabilization, mild relapses occurred in 2 of our patients as well as in the Araki et al case.11 In patient 1, we reduced the application intervals from every 6 to 4 weeks and the patient was relapse-free afterward. Accordingly, an escalation study demonstrated further clinical improvement in rheumatoid arthritis after dose escalation from 4 to 8 mg/kg.13
As demonstrated in rheumatoid arthritis, tocilizumab has a good safety and tolerability profile. Infections are the most common adverse events; however, rates of serious infections remain low at least for 5 years, demonstrating safety of continuous tocilizumab therapy.13 Possible tuberculosis reactivation and opportunistic infections make careful observations essential. Importantly, C-reactive protein is directly downregulated by tocilizumab and cannot be used as a sensitive diagnostic marker. In our patients, no serious adverse events were observed. Reported urinary tract infection and mild oral mucosis have been treated on an ambulatory basis without any complications.
We propose that IL-6 receptor blockade with tocilizumab is a promising therapeutic option for aggressive, therapy-resistant cases of NMO. Larger controlled studies with longer follow-up periods are needed to confirm the efficacy, safety, and optimal responders for tocilizumab in NMO.
Correspondence: Ingo Kleiter, MD, Department of Neurology, St Josef-Hospital, Ruhr-University Bochum, 44791 Bochum, Germany (firstname.lastname@example.com).
Accepted for Publication: October 4, 2012.
Published Online: January 28, 2013. doi:10.1001/jamaneurol.2013.1246
Author Contributions:Study concept and design: Kleiter, Chan, and Gold. Acquisition of data: Ayzenberg, Kleiter, Schröder, Hellwig, and Chan. Analysis and interpretation of data: Ayzenberg, Kleiter, Chan, and Yamamura. Drafting of the manuscript: Ayzenberg and Kleiter. Critical revision of the manuscript for important intellectual content: Ayzenberg, Kleiter, Schröder, Hellwig, Chan, Yamamura, and Gold. Administrative, technical, and material support: Hellwig, Chan, and Gold. Study supervision: Kleiter and Gold.
Conflict of Interest Disclosures: Dr Kleiter reports receiving travel reimbursements and speaker and consulting honoraria from Bayer HealthCare, Biogen Idec, Merck Serono, and Novartis as well as research support from Bayer HealthCare, Novartis, and Biogen Idec. Dr Hellwig reports research support form Biogen Idec, Bayer HealthCare, Merck Serono, sanofi-aventis, and Novartis Pharma as well as speaker honoraria from Biogen Idec, Bayer HealthCare, Merck Serono, sanofi-aventis, and Novartis Pharma. Dr Chan received speaker and consulting honoraria and scientific grant support from Bayer HealthCare, Biogen Idec, Merck Serono, Novartis Pharma, and Teva Pharma. Dr Gold received speaker and consulting honoraria and scientific grant support from Bayer HealthCare, Biogen Idec, Merck Serono, Novartis Pharma, Chugai Pharmaceuticals, Teva Pharma, and Genzyme.
Funding/Support: This work was supported by grants from the German Ministry for Education and Research ("German Competence Network Multiple Sclerosis") (Dr Gold).
This article was corrected for errors on April 29, 2013.
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