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Object get( Object key ) throws ItemNotFoundException?isn't very useful. We already have (or should have) a
boolean contains( key )accessor... if we really want to know, why not use it? --AustinDavid
boolean contains( Object key ) { return get( key ) != null; }In other circumstances it may be better to (a) treat it as an error, and (b) have the error detect ASAP by throwing an exception. Returning null means the error isn't detected until the result is dereferenced. -- DaveHarris In PythonProgramingLanguage? (yay for python), accessing a nonexistant dict key will raise (throw) a KeyError?. However, some method or other overrides that, allowing you to add a default value. I am not sure whether this would rely on exceptions internally. Languages are beginning to support a user-supplied default value. You pass a second argument to the get() which specifies the result to return if the item is not found. This seems like a great solution to me.
claim "Returning null is good, because that is the value meaning 'nothing found', which is not an exception." object "But then, there is no guarantee that the caller will check for null. He might assume that the value is not null, and get a NullPointerException at some undefined location. It will be hard to trace this bug back to its cause." claim "OK, so we should not use null, and throw a checked exceptions instead." object "But then we force the caller to catch the exception, even if a null value is acceptable."goto start At the heart of the first objection, the problem is that Java does not distinguish between possibly-null values and never-null values. It allows a null value to have any reference type, so that it is never safe to dereference such values. If I can say: String is a type which does not include null, but ?String can additionally contain null, then the problem is solved. A get on a Map<String,String> has type ?String. You can pass this value around, but the compiler can make sure that you check it is not null before dereferencing it, or storing it in a String variable. This is something the NiceLanguage extension of Java allows. This point is covered in http://nice.sourceforge.net/safety.html, together with other safety aspects. DanielBonniot
if (!(obj instanceof MyClass)) {...-- EdPoor
int a = 7 ; int *b = new int ; int *c = &a ; void foo ( int * d ) ; foo(b) ; foo(c) ;b is a pointer. What's c? not a pointer, because a wasn't allocated dynamically. What's d? we've no idea whether the value on the other side of the indirect reference was dynamically allocated or not. That is C++ code, so the type of c is a pointer-that-is-also-an-address-or-array-or-array-iterator-depending-on-how-you-use-it. Above it is being used to implement PassByReference because C++ doesn't allow functions to have PassByReference(*) parameters. Well, I assume so, but there is no way of knowing from C++'s type system exactly what the function foo will do with its d argument. As long as foo actually uses the argument d as a PassByReference parameter the program works fine. If it stores the pointer longer than the lifetime of the call, it's a bug. This is one of the flaws with C++'s pointers-that-are-also-addresses-or-arrays-or-array-iterators-depending-on-how-you-use-them. It is why most other Algol-derived languages make explicit the distinction between pointers and addresses and support PassByReference procedure parameters. And it is also why people who have only learnt languages based on C get confused by the fact that Java object references are what are commonly known as pointers. (*) I should have added "or-reference" to that newly coined term, but I didn't want it to become too long and unwieldy!


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Little League Minors compete in CrowfieldJune 26, 2014
Description: Summerville National and Summerville American participate in the Little League District Two championship tournament held in Crowfield.
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Appropriateness Criteria to Assess Variations in Surgical Procedure Use in the United States
Lawson EH, Gibbons M, Ingraham AM, Shekelle PG, Ko CY.
Arch Surg. 2011;146(12):1433-1440.
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This afternoon I was lucky enough to catch up with Capitals prospect Brett Flemming for a few minutes and ask him some quick questions on D.C., Developmental Camp, and movies.
Flemming, the 6'0″, 175 defenseman was selected in the 5th round (145th overall) in this year's draft out of Missisagua of the OHL. Brett is known as an offensive-minded 'D' man with a strong work ethic along with a terrific attitude on and off the ice.
ML: Have you ever been to D.C. before? Any first impressions?
BF: No, this was my first time here. I went on the tour [of D.C. with other Capitals prospects earlier this week] and it was not what I expected…It was nice [Ed Note: What are you trying to imply, Mr. Flemming?]. It was cool to see all the monuments in D.C.
ML: So far, what has been the biggest surprise for you at camp?
BF: Surprise? Probably how nice all the guys are. Everyone is really great to be around in the locker room. All the Hershey guys are great.
ML: You play with a lot of energy and you are very physical, has Coach [Bruce Boudreau] asked you to tone it down at Camp?
BL: Oh no, [laughs] I don't think so. I just try to go all out.
ML: What's it like playing alongside some the [OHL] guys you faced in league play last year?
BF: Well, I played against guys like [John] Carlson and [Stefan Della] Rovere. It was fine I guess playing with them at camp, but when we get back to [OHL] league play, it will be war.
ML: What kind of music are you listening to these days?
BF: Uhh, pretty much anything…Alternative and Country.
ML: What's the last movie you saw?
BF: (Moment of silence, followed by a huge grin). The Hangover.
ML: And what did you think of it?
BF: Oh I loved it! It was really good.
ML: Have you ever done anything like that before?
BF: [Laughs] Oh no, I don't think anyone has done that before.
ML: What types of goals have you set for yourself next year?
BF: Well I hope as a team, we can win our conference. As for myself, I know I'll set a personal goal for points but I have not really thought about it that much.
Brett was just sitting down to eat with fellow-prospect Patrick Wey as I finished up our quick chat. The Capitals' Development Camp concludes tomorrow morning with an intrasquad scrimmage at 10:30 AM.


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Trucking companies offer jobs as business gears up
Birkmire Trucking Co. owner Tim Birkmire climbed into the cab of a tractor-trailer and drove to New York City on a recent night.
Birkmire's Fairview Township-based trucking company hauls freight locally and in 48 states, and if it's necessary to pick up or deliver a load, the boss goes on the road.
"It seems like we're always short a driver," Birkmire, 63, said.
Local and long-distance drivers are in demand here and nationwide in an industry that's been picking up speed despite the recent recession and high fuel costs. Advertisements for drivers are posted daily in the classifieds, on online job sites and on company websites.
"Business is good," said Terri McAndrew, human resources coordinator for the Erie-based Team Hardinger trucking firm.
The trucking boom is part of a larger boom in freight hauling. Freight shipments -- by truck, rail, inland waterway, pipelines and airfreight -- reached an all-time high in December. The Freight Transportation Services Index, which measures monthly changes in freight shipments in ton-miles, was 113.7, surpassing the previous high of 113.3 in January 2005.
The reviving economy is fueling the demand for goods, which in turn is fueling the demand for truck drivers, according to the Department of Labor's Bureau of Labor Statistics. The bureau foresees almost 21 percent growth, or 330,100 new jobs, for heavy and tractor-trailer truck drivers by 2020.
Birkmire Trucking has been consistently growing, and consistently hiring.
"Whenever we get a new driver, we seem to have enough work to need another," Birkmire said.
The company employs about 30 drivers.
Team Hardinger employs about 50 drivers operating out of two sites, in Erie and another in Grove City. Its business is concentrated along the northeastern seaboard, the Midwest and Canada but offers freight service nationwide, according to the company website.
The company currently is looking for about 10 drivers, McAndrew said.
"We've bought brand new trucks that we'd like to get filled and out there," she said. "And we're always on the lookout for owner-operators as well."
The trucking industry additionally offers off-road jobs, for mechanics, dispatchers and in warehousing.
Wayne Natcher, 46, has had three different careers in his 25 years at Birkmire Trucking. Natcher was an over-the-road, or long-distance, driver; a mechanic; and now a local hauler.
"A lot of people look at this job as an opportunity for paid travel and seeing the country," said Natcher, who's done that. "Now what I like is more or less being my own boss."
Natcher schedules pickups and deliveries with local businesses that store large equipment at Birkmire's new multimillion-dollar headquarters in the Sterrettania Business Park. The company also includes storage and moving in its Big Box Rentals containers.
While companies prefer to hire experienced drivers like Natcher, many companies, because of the demand, will hire newly licensed commercial drivers.
"The hardest thing for a driver is to get that experience once he gets his commercial training and license. We try to work with new graduates," McAndrew said.
Fortis Institute, previously Tri-State Business Institute, 5757 W. 26th St., has offered commercial driver's license training, and it may offer it again this year, a school spokeswoman said. Pennsylvania CareerLink, 155 W. Eighth St., can provide additional information on commercial-driver training.
Truck driver wages are expected to increase along with the number of new jobs, according to the Bureau of Labor Statistics.
Team Hardinger is currently restructuring wages and benefits to offer drivers an even more competitive package, McAndrew said.
"It's an exciting time for us and for the trucking industry," she said.
VALERIE MYERS can be reached at 878-1913 or by e-mail.


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SKIPPACK - Florence Bodnar Pacini, 90, of Lewistown, died Sept. 27, 2011, in Skippack.
A Mass of Christian Burial will be celebrated at noon on Friday, Sept. 21, 2012, at the Most Holy Trinity Catholic Church, Sixth and Washington streets, Huntingdon, with the Rev. David Arseneault officiating.
Interment will be in Holy Cross Cemetery, in Huntingdon.
Funeral arrangements are under the care of the Heller-Hoenstine Woodlawn Funeral Home, 200 N. Main St., Lewistown.


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According to a statement by the Hudson County Sheriff's Office, the sheriff's office conducted six arrests and issued 64 traffic summonses, in part of a countywide crackdown on drunken driving during the Thanksgiving weekend. Full story »
Are we seeing a kinder, gentler kickoff to the holiday shopping wars? Hope so. Full story »
Until relatively recently 'Black Friday' was used to describe negative events, as in the Steely Dan song of that title; then some dullard began using it to describe the Friday after Thanksgiving and other parroted this idiocy Full story »
Earlier openings coupled with a more systematic approach to distributing major doorbusters has quelled the Black Friday frenzy. Full story »
Despite it being a holiday and the offseason, the restaurant had the feel of a mid-summer Saturday night, with people eating at tables on the boardwalk and a line to get in snaked around the building. Full story »
The kitchen, located on Neilson Street in Downtown New Brunswick, has served Thanksgiving dinners since its inception in 1989, said Executive Director Jim Zullo. Full story »
As a state and federal holiday, many stores and services will be closed on Thursday. So, here's some things you may need to know throughout the day. Full story »
Transit agencies plan on running extra service to Thanksgiving Day parades in New York and Philadelphia. Full story »
Members of the New Jersey Army National Guard and Air National Guard helped give out fixings for Thanksgiving meals to hundreds of families at the new Keyport Ministerium Food Pantry on Tuesday. Full story »
You know what not to talk about: religion, politics, sex. Here's 10 ideas to get the conversation started around the dinner table. Full story »
Tips on what to wear if you're heading to the big parade in New York City. Full story »
A history of the Macy's Thanksgiving Day parade in pictures and words Full story »
An unsuccessful overnight attempt to stop the flow of water through a 36-inch pipe where a valve had failed means Suez Water crews will need to find another fix Full story »
Thursday is Thanksgiving and most services will closed and many stores will have limited hours. Here's what's open and what's closed in New Jersey on Nov. 26. Full story »
The biggest changes in the holiday getaway routine may be at the airport, due to heightened security after the terrorist attacks in Paris and volumes of people looking to get out of town. Full story »
The new Grover Cleveland service area on the New Jersey Turnpike north in Woodbridge, which emphasis fresh, healthy food, will likely be the model for other highway service areas. Full story »
He decided that if he couldn't kill the bird himself, he shouldn't be eating meat. Full story »
If you're planning to travel across the country for Thanksgiving this week, there's some good news and some bad news. Full story »
What's on your holiday table? Full story »
What's for dessert this Thanksgiving? Lower gas prices for the family road trip. Full story »


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I stepped into the bathroom and saw my friend and her sister making out in the shower, lathering each other with soap. My friend was sliding down her sister's body, rubbing soap all over her especially around her pussy. I stood there grabbing my ha
surprised by my wife…and her friends
There are many dreams and fantasies that one comes up with in the course of a lifetime and, if you're lucky, you may have the chance to live out a few of them. If you have a loving and caring partner you may be able to live out more than most.
surprise, surprise…
I have this fantasy of wild, unabashed sexual fulfillment and I think that now, with the help of my beautiful wife, I'll be able to live it out.
As the fantasy goes, we are on vacation on a romantic island where people can run around playing
2 into 1
My fantasy-come-true…
I had always had a fulfilling sex life. Like anyone else, however, I had a fantasy that was always left unfilled. I had resigned myself to the fact that I would never experience my longing and put it out of my mind.<b
the apprentice
THE APPRENTICE (Tom, Ms. Gray, and Marianne)
My name is Tom. The last few months of my life have been very exciting, since I graduated college. My BA is in business, and I'll be getting my MBA in a couple of years, but in the meantime I
Suggestion to all writers
I have been reading these storys for about 2 years. All of the writers are pretty decent at it for the most part. The only thing I would suggest is something that gets on my nerves when reading a story. Some of you seem to think that having a 19 y
gladys and me 5
Gladys and I sat on the sofa and watched charlene as she eased herself up to her feet. She was such a hot little babe and my cock was stirring again. Gladys saw immediately and wrapped her fingers around it. She turned to charlene and spoke. "this is
The Backdoor Neighbors
It had been several months since I had noticed my backdoor neighbors, Susan and Allan, out in their yard. I called and waved to them both. Allan had been home a lot more lately with the birth of their third child; it was obvious he was trying to be
Kids Yeah 2!!
Kids! Yeah 2!!
This story takes place at a small park. This park has ballfields, playground, and a walking trail. The walking trail circles the entire park, and also has a small spur trail going off into the woods for about a quarter of a mile. Th
Mom's best friend
Mom's Best Friend
My story began a long time ago actually when I was 8yrs old. I was in my back yard when i saw my next door neighbor who was 23 at the time in bra and panties ironing. She was HOT. She was tall and thin with long brown hair an
just plain fun
My story begins with three close friends. Jb,Jen, and Chasity.One night we decided to go to Chas's uncles and we were drinking. We then headed back to my house, where we decided to watch a movie. I was sitting on a chair and the two ladies were sitti
Jake,Kim and Mike
Ever since that Saturday a month ago my niece Jake (short for Jacquelyn) have been carrying on a torrid paced affair. She and I are screwing 3 or 4 nights a week. The pace is wearing me out I am having sex sometimes twice a day. The only time w
my husband want the cat more than me…
Once upon a time in a land called fantasy there lived a girl called Olivia Farey she lived in malton north yorkshire england, she knew a girl called Faith, they had lots of great lesbian sex, yes thats right, lesbian sex!! half unconsious sex that is
An Orgy by the Eagles Nest
This story is not about an adventure of mine, but I was fortunate to view it and capture it on videotape. I was in the mountains camping, hiking and above all doing a video documentary of a nest of eagles that I had discovered the week before. Not
Heathen Fest
Keep in mind that, in this fantasy, all people and celebrities are alive and in the prime of their careers. It's my story, I can do what I want, so there! Nyah! Nah, seriously though, let me know if you like this one.
"Yeeeeaah! Breakin The L
Chrstine IV–Group Sex Fantasy
Several weeks later, I told her that everything was setup for her ultimate fantasy. She seemed surprised and asked if I was just kidding her. I told her that it is set for Saturday night. She said that she was a bit nervous about this, but
The Wedding Party
The crowd on the dance floor were doing another round of the Electric Slide. A dance to highlight any black wedding reception
" I can't believe the hotel screwed up you guys reservations"! Dasia complained
"It will be fine girl", Niqui
Working for Trevor
Hi. My name is Tyra. I consider myself to be fairly good looking. I'm a petite 5'2″ with long black hair and green eyes. I'm very slender with a nice round ass and C-cup breasts. I was recently fired from a job because I didn't allow my boss to fuck
Sharing My Wife
"Heat of the Moment"
You can take this as just a story if you choose, but I will tell you that it is not, I have not even changed the names of those of us involved.
My wife and I were just sitting at home on our couch, my wife ,Dana


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Our Bodies, Our Books
Our Bodies, Ourselves: A New Edition for a New Era
by The Boston Women's Health Book Collective (Touchstone, 2005)
With colorful photos of hymens, this "book by and for women" has sold more than 4 million copies in 18 languages. The latest edition is a bit trendier than earlier ones, featuring info on boob jobs, bikini waxes, and the meaning of "vulva chic."
Women's Bodies, Women's Wisdom: Creating Physical and Emotional Health and Healing
by Christiane Northrup, M.D. (Bantam, 1998)
The author, a feminist holistic physician, believes bodily dysfunctions can be healed, and even prevented, by utilizing herbs, receiving acupuncture, and making more friends.
Upcoming Events
Woman: An Intimate Geography
by Natalie Angier (Anchor, 2000)
Addressing the reader as "Sister," Angier, a Pulitzer Prize-winning biology writer for The New York Times, offers a "scientific fantasia of womanhood," celebrating all aspects of the female body. The X chromosome, she says, has a "vastly higher gene richness" than the "depauperized little stump" we call the Y.
Health Issues for Women of Color: A Cultural Diversity Perspective
edited by Diane L. Adams, M.D. (SAGE Publications, 1995)
Black, Native American, Asian, and Middle Eastern women in the United States are dying far earlier than the rest of the American population. This book was the first to carefully explore, and protest, the disparity.
The Second X: The Biology of Women
by Colleen Belk and Virginia Borden (Custom Publishing, 1998)
The authors upset the conventional idea that women are mini-versions of men.
The New Harvard Guide to Women's Health
by Karen J. Carlson, M.D.; Stephanie A. Eisenstat, M.D.; Terra Ziporyn, P.H.D. (Belknap Press, 2004)
An upbeat, alphabetized encyclopedia with entries on ordinary bodily concernsanxiety, fat-fear, mysterious rashesas well as rare reproductive diseases.
The Big Bang: Nerve's Guide to the New Sexual Universe
by The Writers at Nerve (Plume Books, 2003)
Good pictures of twiggy hipsters, mostly naked, accompany explanations of concepts like "foreplay," "female ejaculation," and "sexual fitness." The chapter on STDs is simply titled "Read This Chapter."
The V Book: A Doctor's Guide to Complete Vulvovaginal Health
by Elizabeth G. Stewart, M.D. and Paula Spencer (Bantam, 2002)
The authors encourage women to "loosen up" and talk about what's "down there." The guide covers anatomy, self-care, a vast array of minor diseases, and strategies for better communicating with your doctor.
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Top Definition
a device use for flying around...
back in my day a hot air balloon was a flying device, but wtf is it now?!?!
Young Reezie tarafından 31 Ocak 2008, Perşembe
Trending Now
Can you define these popular missing words?
Photos & Videos
A conveyance consisting of a sturdy large basket that can hold 4 or more people & is propelled up into the air by a gas burner. They go over 10,000 feet in elevation!
That hot air balloon was really thrilling to ride in & they're awesome to see!
Starchylde tarafından 28 Mayıs 2016, Cumartesi
When one person blows up a balloon inside another persons anus.
Tommy performed the hot air balloon on his gay lover before it popped and damaged his butthole.
big al 69 tarafından 4 Mayıs 2013, Cumartesi
1. A sexually act in which a man stands slightly bent over with a woman kneeling behind him. She will purse her lips tightly around his anus. She then tugs on his flaccid member from between his legs as he releases a preferably hot fart in her mouth, thus expanding her cheeks much like that of a hot air balloon. Aviator goggles and scarf are optional.
Friend #1: I was able to talk Nichole into letting me give her a hot air balloon last night.
Friend #2: I don't know what that is, but it sounds fucking sick.
Friend #2: I don't know what that is, but it sounds fucking sick.
The Taste of Lemonade tarafından 7 Kasım 2009, Cumartesi
farting into an open vagina while lighting it on fire.
I blind folded my girlfriend and said "open up" but instead I bent over and lit my lighter and gave her the hot airballoon.
jomo85 tarafından 11 Nisan 2006, Salı
Performing oral sex on a woman in 69 position and she farts into partners nostrils during act.
I was eating my girlfriend out in a 69 and she fired up a hot air balloon in my nose.
oneaze tarafından 6 Eylül 2011, Salı
Verb. The act of farting in an open vagina.
Heather jumped on Snowbird's back and was riding him just as he gave her a hotair balloon. She nearly rose to the ceiling.
Svendervittle tarafından 23 Ağustos 2010, Pazartesi


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Wascal Wabbit
Thursday, February 21, 2013
One of my life goals is to make clear, positive and separate my love of cooking (and love of good food) from my habit of eating for love.
Is it possible for a habit that has gifted me with repeated bouts of obesity with all the trimmings ever to be viewed as positive?
Hmmmmm. First of all I will need to clean up my language. This site wouldn�t let me say sh__, even if I had a mouth full of it, and I do not mean that as a criticism. I suspect that it is actually an example� of the kind of logic that has me saying and thinking the phrase �eating for love.� Gonna have to hunt this bunny to it�s hole. Stay tuned.
*** When I say "clean up my language", I'm not talking about censoring my vulgarity. I am talking about revisiting catchy phrases that are actually obfuscating that which they would describe... platitudinizing? Blue laws have a way of working in favor of the very things they would prohibit. I have a feeling using grossly inarticulate simplifications to describe my eating history works in much the same way. Although I have not fleshed it out as yet, the phrase "eating for love", although it means well, is actually doing more harm than good. Why is this important? Because some very, very specific things have branched out into all manner of destructive behaviors through the course of my years. What I am looking for is the thread of truth that runs through all this muck.
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"platitudinizing" - I now have a new word! Language can and does obscure true intent because we are more comfortable with vagaries. I am interested to follow your path of discovery about this "eating for love", I am sure that there will be nuggets of wisdom available.
Keep it up - I know that un-examined lives are much easier to live, but not necessarily fuller because of it.
1311 days ago
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1314 days ago
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Noel finally realized how different it was for me, a person who had dedicated a huge portion of life to elevating food to an art form and whose identity, profession, reputation and self esteem were intricately involved in that expression, than it was for him to adapt to eating purely for sustenance on a low carb diet. I told him to try imagining that he could still use a computer but there would be no Internet connection and he'd have to use DOS. Baking and throwing pots/firing kilns are the two things in this life for which I seem to have a genuine 'gift'. But I've always known that if I wanted to stay healthy into old age there would have to be sacrifices and adjustments made. I'm declaring 'Be Kind to Your Tired Old Organs' year in 2013.
As for profanity, well, for me it's like religion in that it simply doesn't exist. To speak, think and write without words that have zing! pop! Ka-POW power would be the same as eating utterly bland foods. No thank you. Of course, if everyone felt as I do, those words that are considered by some to be profane would no longer have their spiciness, would they? Conundrum! No one has ever been able to explain to me why and how the word sh!t has any different denotation that the word feces. SP will let me talk about poop in one form but not the other. It's just silliness on a grand scale. I can say copulate, fornicate, coitus, the beast with two backs...and no one blanches. But trot out the Eff word and, in some circles, there will be gasps. Silliness. I'm saying it is a bad thing and I resent having my brand of expression curtailed.
1315 days ago
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Taking away my ability to swear directly only caused me to find creative ways to swear around it (as you well know).
Be careful around them rabbit holes, tho-- sometimes you fall in and end up in wonderland.......
1315 days ago
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Well, sh!t. That's how we potty mouths do it!
1315 days ago
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Anyone noticed that there's been absolutely no new icons available at mediaicons.org for some months.
I think the upload is buggered so no-one can upload any new content.
I've tried informing the site owner using the "contact" form but this is also buggered!
Anyone know who owns the website?
Mediaicons.org - Dead?
Started by opearmain , Jan 08 2009 07:24 PM
3 replies to this topic
Posted 08 January 2009 - 07:24 PM
Posted 09 January 2009 - 12:27 PM
I managed to contact the owner of the website and have had a reply saying he'll take a look. Fingers crossed things will be back to normal soon.
Posted 19 February 2010 - 07:59 AM
Might want to contact him again Seems as if either his site is gone (read would really suck) or somehow someone's Blog site is crashing the party..
Posted 15 June 2010 - 10:52 PM
Edited by ExitRooster, 15 June 2010 - 10:53 PM.
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Pages Up for Adoption > The Hindukush > Tirich Mir > Additions and Corrections
Tirich Mir Additions and Corrections
[ Post an Addition or Correction ]
|Untitled Comment
Voted 10/10
|Like all mountains in Karakoram, Himalaya, Hindu Raj and Hindu Kush Rawalpindi - Islamabad is the gateway to the high mountain of northern Pakistan. Islamabad International airport link the world with dozens of international flights each day. One can reach Chitral by two road links #1 is via the Lawari Pass; One can take a road journey on Grand Truck Road also known as GT road towards NWFP and after about 2 hours turn right to the Mardan Valley before climbing the famous Malakand Pass (this is area where first time British Soldier wear Khaki uniform - Shalwar Kameez, which still the Pakistani soldier wear in this area) the same which link to Swat Valley, one can have lunch in roadside Afghan resturants before turn left to Dir and further to Lawari Pass. All the road journey from Islamabad to Chitral will take about 10 to 12 hours. One can also fly from Peshawar to Chitral. Be prepared for delays due to bad weather, road blockage in the Lawari Pass Section due to landslides.
#2 road link is via the KKH to Gilgit and by the Shandur Pass (the famous and the height Polo ground on earth) to Chitral. Gilgit is about 16 to 18 hours from Islamabad and road journey to Chitral from Gilgit is another day drive.
|Posted Dec 24, 2005 12:53 am
Hasn't voted
|"In 2006 expeditions did face refusal at Islamabad to get permits . This will not happen in 2007, in case expeditions face any delays it is advised to contact the local government in Chitral for special permissions."
You are in no position to give any guarantees about whether permits will be revoked in 2007 and it's irresponsible to do so!!!
Also! You know full well that the Chitral government is in no position to issue climbing permits were the Ministry of Tourism to decline in 2007 for any reason.
|Posted Apr 22, 2007 6:38 pm
Hasn't voted
|would not have mentioned it IF it was not discussed with the local government.
Try it and see.
|Posted May 27, 2007 5:27 am
|Re: Permits
Hasn't voted
|So the local Chitrali government can officially issue climbing permits if the Ministry of Tourism revoke permits at the final hour again? Is this legal?
|Posted May 29, 2007 6:58 pm


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Rock bands classified as "progressive" have been pairing off with symphony orchestras for decades, sometimes with positive results, a good example being Procol Harum Live in Concert with the Edmonton Symphony Orchestra, that group's biggest selling album. According to guitarist/singer
Tommy Shaw
, who has been fronting
since a legal settlement with former singer/keyboardist
Dennis DeYoung
gave him, guitarist
James "JY" Young
, and mostly retired bass player
Chuck Panozzo
the right to perform under the band's name in 2001, the group mostly avoided hooking up with orchestras until an offer came in from the Contemporary Youth Orchestra (CYO) of Cleveland, OH, a massive ensemble of 115 musicians along with a 56-member choir, all of them teenagers. Their live encounter with the CYO constitutes their second release on Universal's New Door imprint, formed to revitalize the careers of veteran acts with large catalogs in the company's archives, following the 2005 covers collection
Big Bang Theory
. Actually, the idea of coming up with orchestral arrangements for
songs is not a bad one, or, at least, it wouldn't be if the present group was willing to choose from its entire repertoire, including the more melodic ballads written by the departed
. But a decision seems to have been made to avoid giving royalties to the band's former leader, so the songs all have to be
compositions, numbers written by the present group, or covers. The result is a record that finds
rocking harder than it perhaps should under the circumstances. The CYO may be a worthy outfit, but most of the time it's nearly impossible to tell because they are inaudible as pitted against the amplified rock group. Early on, it sounds as if the mixing desk hasn't quite configured the room correctly, a common enough problem at concerts; the sound improves noticeably as the disc goes on. An early highlight is an arrangement of "I Am the Walrus" that follows
the Beatles
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. The orchestra gets to peek out here and there, notably in the introduction to "Miss America," but it spends a lot of the evening doubling
Lawrence Gowan
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OnQ is proud to partner with Highmark for this series of special reports focusing on connections between our habitat and our health. OnQ's staff explores everything from air and water quality to mold in our homes. Another featured segment looks at cancer caused by environmental factors.
Monday | October 1 at 7:30pm
COVER STORY: THE AIR WE BREATHE - OnQ begins another week of Highmark-sponsored special programs devoted to offering healthier choices. Michael Bartley begins the indepth coverage with a closer look at air quality in Western Pennsylvania, reporting on why some health experts believe this region's air is making us sick.
Department of Environmental Protection
Children's Hospital of Pittsburgh
ALSO FEATURED: Burning Hazardous Waste - OnQ contributor Harold Hayes reports on past and present fears among people living down wind of an incinerator in East Liverpool, Ohio.
AND: THE PITTSBURGH FISH STUDY - In 2005, OnQ followed researchers fishing local rivers to determine if cancer-causing contaminants are seeping into the rivers and into our tap water. In this 2007 follow-up report, Michael Bartley has the startling results of the major study.
Center for Healthy Environments & Communities- University of Pgh.
Tuesday | October 2 at 7:30pm
COVER STORY: Mold, Moisture & Our Homes - Molds are microscopic organisms essential to our environment. Outdoors, mold helps break down organic matter such as fallen leaves. But indoors, mold can create unhealthy living conditions. OnQ's Tonia Caruso takes a look at what homeowners can do to prevent mold from growing in their homes.
EPA Mold Information
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AND: Rachel Carson's Legacy - Long before most people understood the crucial connection between our environment and our health, a woman from Springdale, Allegheny County raised a warning flag. OnQ contributor Dave Crawley reports on "Silent Spring" author Rachel Carson, a groundbreaker in the world's environmental movement.
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Center for Environmental Oncology, Univ. of Pittsburgh Cancer Institute
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[QUOTE=elliottsmith;986712]Yes there are lots of rescues and animal shelters but none of the let us have dogs because we have children and the general policy is no dogs to families with small children under 12 years. So that's why we are 'buying' a dog.[/QUOTE]
Yeah, we got "denied" for a dog at the shelter. LOL. Sooooo hilarious. Cause my wife was a little too honest and told them about one of our dogs jumping our fence and running away a few years back. We were specifically looking for a dog that could not accomplish this feat. Hey, but good new! Michael Vick was able to adopt one....so all is right in the world :)
We ended up just taking in a young stray (for free!) a couple weeks later and that was 6 months ago. She's a great dog.


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at Oregon State
Where: Reser Stadium, Corvallis
More Oregon State vs. Washington
Despite Washington's record, it is ranked No. 47 among all FBS teams in Jeff Sagarin's national power ratings. How? The Huskies have beaten USC (No. 11 in this week's AP poll) and Arizona (No. 18) -- both of which have beaten Oregon State -- and have played the hardest schedule in the country, according to Sagarin's ratings. Sagarin, by the way, ranks Oregon State's schedule the ninth toughest in the country.
Washington's Achilles' heel is pass defense. The Huskies rank No. 111 among FBS teams, giving up 262.56 yards passing per game. This week they play the top passing team in the Pac-10 in the Beavers, who are averaging a conference-best 279.89 passing yards.
Famous alumni: Football -- Warren Moon, Hugh McElhenny, Jim Mora. Basketball -- Brandon Roy, Nate Robinson, Detlef Schrempf. Film/television -- Dyan Cannon ("Oscar for Bob & Carol &Ted & Alice," "Heaven Can Wait," "Ally McBeal"), Patrick Duffy ("Dallas"), Dawn Wells (Mary Ann of "Gilligan's Island"), Bruce Lee ("Enter the Dragon"), Anna Faris ("Scary Movie"), Rainn Wilson (Dwight on "The Office"). Music -- Kenny "G" Gorelick. Politics -- Tom Foley (Speaker of the House). Business -- Karsten Solheim (founder Ping golf clubs), Irv Robbins (co-founder Baskin & Robbins).
Player to watch: Junior quarterback Jake Locker leads the Pac-10 in total offense at 270.3 yards per game, but he transformed himself into a very different player than he was in his first two seasons, when he was a true dual threat as a passer and runner. In 16 games as a freshman and sophomore, when Locker had 3,740 yards offense, 31 percent of his yards -- 1,166 -- came on runs. This season, Sarkisian has turned him into much more of a pocket passer. Locker has 2,433 total yards, with 9 percent (230 yards) coming on runs.
Last time against Oregon State: In Seattle, the Beavers didn't have much problem beating the Huskies 34-13 as Washington was without Locker, who was out for the season with a broken thumb. James Rodgers ran for touchdowns of 52 and 55 yards and caught a 33-yard touchdown pass, and quarterback Lyle Moevao completed 18 of 22 passes for 191 yards and had just one incomplete pass in the first half for OSU.
Series history: The Beavers' win last season was their fifth in a row against Washington, a major turnaround in a series that had been dominated by the Huskies, who still have a 57-32-4 overall edge. Before OSU's streak started in 2004, Washington had won 25 of the previous 27 meetings. The Huskies have an 18-8 edge in Corvallis.
Connections: Washington has two players from the state of Oregon -- reserve wide receiver Jordan Polk, from Lincoln High School, and offensive lineman Scott Shugert, from Oregon City High School. Oregon State has 11 players from the state of Washington, including tight end Joe Halahuni from Orting (near Tacoma), punter Johnny Hekker from Bothell (north of Seattle) and center Alex Linnenkohl from Olympia. Also, OSU running backs coach Reggie Davis was a standout tight for the Huskies from 1994-98.
-- Mike Tokito
Follow him at www.twitter.com/mtokito


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Oldies radio provides us with the best love lessons life has to offer. Check out what you can learn from tunes of yore, then add your favorite one to our list.
Did you ever turn on the oldies station and feel like those classic songs were describing your current love life perfectly? That's probably because as you were growing up, no matter what generation you grew up in, these songs taught you how to love. From early rock and roll to Motown to classic girl groups, these songs teach us so much about what love is, how much it hurts when it goes wrong, and how we can get it right.
Will You Still Love Me Tomorrow?
One of the greatest rock ballads of all time, this song (penned by Carole King and Gerry Goffin, and performed by the Shirelles) captures the complex miasma of emotions that entangle yet distinguish lust and love. "Is this a lasting treasure, or just a moment's pleasure?" the singer asks of her beau as they get misty-eyed in the moonlight. "Can I believe the magic in your sighs? Will you still love me tomorrow?" (even if I give you what you want tonight). A warning to hormonally charged teens everywhere, this song cautions that physical chemistry may or may not lead to deeper love down the road.
The Tracks of My Tears
Smokey Robinson had a way of making a sad song sound glad. But just like the gloom behind the Miracles' shining vocals, behind the façade of the character in this song lies a sad, broken-hearted man. Anyone who's ever been dumped by someone they really loved and tried to pretend to be fine when they saw their ex in public knows the ritual he's going through. We laugh, we smile, we go on ridiculous rebound dates with the first eligible people we run across. Outside, we're masquerading, but inside our hopes are fading. It's a theme Robinson would take to No. 1 years later with "Tears of a Clown."
Save the Last Dance for Me
Love is not about possession, and nobody understood that more than this song's co-creator, Doc Pomus. A victim of polio who used crutches to get around, he still enjoyed going out with his wife, a Broadway performer and dancer, and it wasn't a problem if she wanted to dance with other men—as long as she'd never "give her heart to anyone" and made sure to save her true love for him at the end of the night. This song teaches us about the tender love that happens at home that's only enhanced by freedom outside the home. And as performed by Ben E. King and the Drifters, it actually makes for great slow dancing.
Three Times a Lady
We know, we know—Lionel Richie is a little soft and a little cheesy. (Remember "Dancin' on the Ceiling"?) But this song, written while he was still in the Commodores, was based on a speech his father had made to his mother on their 37th wedding anniversary. It chronicles the many roles Richie's mother played in her marriage and her family—she was a lifetime lover, a great helper as a co-parent, and a best friend. This song teaches us that our soul mates must meet our needs in a variety of areas, not just in romance or financial help or camaraderie or raising children with us, but a combination of some or all of these.
This raucous soul song about a woman who earns her fair share of the family wages and wants the respect of her man made Aretha Franklin famous. But it also taught a lot of us about how people should treat each other in a relationship. A long-lasting relationship should be a place where two equals meet, and if one person doesn't give the proper respect to the other, degrades the other, or belittles the other's contributions to the relationship, that person might walk in and find his partner gone! Lest we think this is only a lesson for men who don't respect women, we must remember that the song was written and originally performed by Otis Redding.
Shop Around
Once again, here's a song written by Smokey Robinson (and Berry Gordy) in which a mother teaches a young man (and us) a very valuable lesson about love. Lots of people are going to have chemistry with us, so it behooves us to take our time, learn what type of person we enjoy being around, and not settle for the first person who agrees to go on a date with us. It's important that we "shop around" until we find someone who's compatible with us in all the areas so important to a lifetime of happiness. Or to put it more bluntly, "Pretty girls come a dime a dozen/Try to find one who's gonna give you true lovin'!"
You Can't Hurry Love
This gem of a song, written by the fantastic Motown team of Holland-Dozier-Holland and recorded by Diana Ross and the Supremes, is another in which a mother imparts wisdom to her child. This time, the advice is for people who have already "shopped around" and have endured heartache and loneliness in their struggle to find the right person. It may seem hard for us to be alone and wait for the right person to come along while a seemingly endless sea of losers swims by. But "love don't come easy—it's a game of give and take." Love can come to any of us, if we just have the patience to keep "hangin' on" until we meet someone with the right combination of chemistry and deep compatibility. That doesn't mean we shouldn't take actions to find that special someone, but at the same time, we need to trust and give it time, and not get discouraged by the so-so dates we might have to endure along the way.
There are so many great oldies songs that teach us important lessons about love. What are your favorites? What are the songs you heard in your youth that prepared you for the trials and joys of romance?


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Sociology Full-Text Collection
Research Methods
Sociology of Youth
Call for Papers, South African Review of Sociology
Special Edition 2014
Abstracts: May 31, 2013 The South African Sociological Association (SASA) is represented in Research Committee 34 Sociology of Youth at the International Sociological Association. SASA is a partner with the BRICS countries (Brazil, Russia, India, China and South Africa), and jointly they are developing theory and practice of youth sociology and youth research at an international level. Accordingly, the special edition of SARS 2014 Sociology of Youth, aims to contribute to this project.
The BRICS countries are cooperating economically and politically, providing the international sociological community with wide-ranging opportunities for youth research. The Sociology of Youth is therefore located within the different stages of change in the partner countries: China and Russia have moved away from communist to post-communist economies; Brazil has experienced regime change from dictatorship to democracy; India is balancing rapid growth and acute poverty; and South Africa is building a developmental state. Contributing papers should be located in the South African context. Additionally, the sub-themes below, (which cut across the BRICS counties), should undergird contributing papers.
1. Concepts, demographic characteristics and assumptions about SA youth
2. Identity and generation
3. Consumption and leisure
4. Family, marriage and sexuality
5. State and political values
6. Education and employment
7. Internet participation and communication
Finally, the approach to the Sociology of Youth seeks to unite professional knowledge, scientific consciousness, and social commitment to work on problems and issues of youth. Contributing papers should therefore expand upon the following proposed foci: priorities, continuities and ruptures. In other words, papers must lead to an understanding of changing priorities; identify undetected and/or un-researched movements; and set out future concerns and challenges for youth research.
Guest editors:
Jayanathan Govender (Department of Sociology, Nelson Mandela Metropolitan University and Council member of the South African Sociological Association)
Tom Dwyer (University of Campinas, Sao Paulo, Brazil and President of the Brazilian Sociological Association)
Abstracts: 31 May 2013
Papers: 30 August 2013
Please email submissions to email@example.com
Sociology of Youth
Call for Papers, South African Review of Sociology
Special Edition 2014
Abstracts: May 31, 2013


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Histoire Naturelle - Max Ernst - Limited Edition Portfolio
This marvelous portfolio contains 34 plates created by Max Ernst (1891-1976), German painter and sculpture and one of the founders of Surrealism. The original work was published in Paris in 1926 in an edition of 306. In 1972 the portfolio was reprinted in Germany in an edition of 1200 copies. 400 copies were printed in English and reserved for publisher Harry N. Abrams, Inc. in New York. Jean Arp, the co-founder with Max Ernst of a Dadaist group in Cologne, wrote the introduction to the original portfolio and it is reproduced in this edition. This copy is number A255. The plates Measure 13" wide x 19.75" tall. They rest in a cloth covered clamshell box with original shipping carton. It is in excellent condition. Truly an excellent opportunity to own a piece of 20th Century art history. (Stock Number 003Ernst) SOLD
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The Pediatric Infectious Diseases Society (PIDS), on behalf of MedImmune, Inc., will present the first annual Viral Respiratory Diseases Fellowship to Angela Peck, M.D., of Seattle Children's Hospital and Regional Medical Center.
The award, which includes a $45,000 per year grant for two years, was established to stimulate and support clinical research related to viral respiratory diseases. PIDS will present the award to Dr. Peck on May 1 at a dinner coinciding with the annual meeting of the Pediatric Academic Societies in San Francisco.
"We are very proud to continue our support of the medical research community by sponsoring the first PIDS fellowship," said Frank Malinoski, M.D., vice president, medical affairs, infectious disease at MedImmune. "The recently created PIDS fellowship program will complement MedImmune's pediatric fellowship program, which helps advance research and new discoveries in the area of pediatric infectious diseases."
Dr. Peck's research goal is to evaluate factors that influence the acquisition of respiratory virus infection and disease progression among immunocompromised children and adults to ultimately guide implementation of preventive and treatment strategies for viral respiratory illness. She is also one of six pediatric fellows to receive $35,000, as part of MedImmune's $210,000 Pediatric Fellowship Program, which is designed to stimulate interest and research in the area of viral respiratory pathogens.
"My goal is to use the support of these generous awards to study parainfluenza virus infections in hematopoietic stem cell transplantation recipients," said Dr. Peck. "I am honored by the vote of confidence these fellowship awards give to my potential to make a meaningful contribution to improve the health of this vulnerable patient population."
Dr. Peck's work is being conducted through the Seattle Cancer Care Alliance at Children's Hospital and Regional Medical Center, Fred Hutchinson Cancer Research Center, and the University of Washington. She earned her medical degree at Vanderbilt University School of Medicine in Nashville, Tennessee and completed her residency in pediatrics at the University of Washington in Seattle.
Consistently ranked as one of the best children's hospitals in the country by U.S. News & World Report, Seattle Children's serves as the pediatric and adolescent academic medical referral center for the largest landmass of any children's hospital in the country (Washington, Alaska, Montana and Idaho). For more than 100 years, Seattle Children's has been delivering superior patient care while advancing new treatments through pediatric research. Seattle Children's serves as the primary teaching, clinical and research site for the Department of Pediatrics at the University of Washington School of Medicine. The hospital works in partnership with Seattle Children's Research Institute and Seattle Children's Hospital Foundation. For more information, visit www.seattlechildrens.org or follow us on Twitter or Facebook.
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Since the late 1970s "French feminism" in the anglophone academic world has signified the particular kind of thought and writing produced by certain French intellectuals, especially Julia Kristeva, Hélène Cixous and Luce Irigaray. These writers do not in fact work together and their work does not comprise a coherent intellectual movement: Kristeva and Cixous would distance themselves from what they understand "feminism" to mean, especially in Anglo-American discourses, and Irigaray is wary of the term, requiring its definition before considering her allegiance. That said, they have all been associated in different ways with sections of the French feminist movement during their intellectual careers, and the intellectual work of …
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Martin, Alison. "French Feminism". The Literary Encyclopedia. First published 19 December 2003
[http://www.litencyc.com/php/stopics.php?rec=true&UID=1357, accessed 01 October 2016.]


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The determination finally paid off for Krista White, 25 -- who previously auditioned for America's Next Top Model 12 consecutive cycles in a row -- as she was named cycle 14's winner on Wednesday's episode. The Palm Bluff, Ark., native went stiletto-to-stiletto with finalist Raina Hein, 22, in an Anna Sui fashion show in New Zealand before sweeping the title.
"I feel, just overwhelmed, I can't believe it's just me," White exclaimed on the show. "Twelve cycles trying out and it's me! I just wanna pinch myself or something. No one ever thought it would be me."
White -- who had the best photograph three weeks in a row prior to the finale -- was known for her unique contortions of her body while exuding high fashion poses in each of her photographs, one that even made Vogue editor-at-large and ANTM judge Andre Leon Talley choke up. "I'm very emotional. I think it's exceptional work," he said of one of her photographs from an "ugly-pretty" photo shoot featured on the show. "If you went to a go-see for John Galliano, you would be booked. You have no idea how beautiful it is to me."
As the winner, White will receive a $100,000 contract with Cover Girl, a cover and spread in Seventeen magazine and a contract with Wilhelmina models.
"You learned and you listened and you blossomed," Banks said. "There's an honesty and a rawness that is so beautiful. And we think that you can have an international career." --David Yi
Tell us: Do you think Krista deserved the title of America's Next Top Model and will she go far as a model? Martina Monica Tolot/The CW
America's Next Top Model Picks a Winner
Martina Monica Tolot/The CW


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To the Editor.–I must take issue with the brief clinical note by Drs Vega and Lucas that appeared in the August issue of the Archives (111:913, 1976). In the "Comment," the authors question the value of angiography in massive lower gastrointestinal bleeding and point out that "since these patients are usually elderly, have other cardiovascular problems, do not tolerate undue delay, and can tolerate only one major operative procedure," angiography is of questionable value.
This concept is contrary to more recent experience in dealing with massive lower gastrointestinal bleeding, the major point being that angiography not only offers a diagnostic modality in demonstrating the bleeding site, but also offers a very effective method of treating diverticular hemorrhage via the use of selective infusion of vasopressin (Pitressin). Casarella et al1.2 pointed out, as was the case in the patient described by the authors, that demonstrable diverticular bleeding appears
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Happy Saturday. Thank you for your support of Daily Thunder. One week.
As KD closes in on his MVP, I can't help but watch this commercial and smile. I wonder what it's like for KD to see that skinny, awkward kid putting on his shoes and think he was going to win an MVP in a few years.


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The Rev. Vernard Tasker went home to be with the Lord March 12, 2013.
He was the former pastor of Church of God of Prophecy in Elkins. He is survied by 11 children.
His funeral will be conducted at 11 a.m. Saturday, March 16, at Burdock Funeral Home in Oakland, Md.
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Ever since they opened in April, the owners of Baan Thai at Napili Plaza have been slammed with locals who live in the area, craving noodles, curries, rice dishes and soups.
As the story goes, two brothers from Molokai married two sisters from Thailand, and the result is a restaurant with authentic and exotic Thai cuisine combined with local favorites.
"I married my wife, Namfon, nine years ago," says Mark Babayan, "And then one time my brother, Keith, came with me to Thailand, and he met Onchan and they got married."
Article Photos
Sisters Onchan and Namfon Babayan (from left) are originally from Udonthani in Northeast Thailand.
The Maui News / CARLA TRACY photo
Namfon is the chef of the bunch and she was sent to Bangkok to attend international culinary school to take her knowledge of fresh herbs and Thai cooking to the next level.
Baan Thai is located where the smoothie shop used to be next to Boss Frog's and two doors down from Napili Market. Its hours are 10:30 a.m. to 9 p.m. daily for lunch and dinner.
It's more of a take-out affair, but there are 26 seats inside in air-conditioned comfort with nice paintings of elephants and such; and eight seats outside on the patio area. Popular pupu include chicken and pork satay, Siam wings, fresh summer rolls and calamari. Hot entrees include tom yum soup, shrimp pad Thai, squid salad, Thai green curry, pineapple fried rice, chicken katsu and kalbi ribs. Call 214-6470.


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Product DescriptionBuck Gardner's Spitfire call has spunk and is ready for anything the ducks can throw at it! Each of these great calls has a short barrel and a "Sorta-single" combo, which is easy to control and ensures full range. Each comes with a .065" thick stainless band and a velvet carrying bag and cord lock.


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LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
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Adapting to Evolving Business Environments Is...
Christofer Cunning, Ph.D., senior marketing manager at Life Technologies, says that reproducibility, toxicity concerns, and the ability to successfully transfect primary cells and difficult-to-transfect cells, including immune cells and stem cells, remain challenging in siRNA experiments. "In general, people have used vector approaches with viral delivery systems for difficult transfections," he says. "Use of viral vectors, however, remains time-consuming, requires cloning steps, is relatively expensive initially, and may require significant safety precautions." In addition, while electroporation has been widely applied, "it requires strict adherence to already set protocols and a lot of siRNA."
To address these issues, Invitrogen launched its Neon™ transfection system earlier this year. In contrast to other systems, Neon allows transfection to take place in a pipette tip, using as few as 2x104 cells. "This technology is amenable to changes in protocols that can be defined by the user," Dr. Cunning asserts.
Unlike standard cuvette-based electroporation chambers, the Neon system uses a biologically compatible pipette tip chamber that generates a more uniform electric field. The company says this design allows better maintenance of physiological conditions resulting in high cell survival compared to conventional electroporation. A universal reagent kit allows use with all cell types.
Invitrogen recently launched Invivofectamine™ for in vivo siRNA transfection. The company claims that in contrast to other marketed products, Invivofectamine can be injected in small volumes (microliters as opposed to milliliters) and without high pressure, thereby minimizing the potential of inconsistent results and gross harm to the subject animal.
This reagent also reportedly provides stability to siRNA so that it remains intact and ready to perform the selected knockdown. Invitrogen has demonstrated successful delivery of intact siRNA molecules via direct injection into established tumors, tail vein injection to the liver, kidney, lungs, spleen, and pancreas, as well as effective and specific knockdown in these tissues.
Roche Madison was formed following Roche's purchase of Mirus Bio in 2008. It has developed Dynamic PolyConjugate (DPC) technology specifically to transfect and deliver siRNA in vivo. David Lewis, Ph.D., program director for RNAi, says the special properties that enable in vivo siRNA delivery include a positively charged membrane-active polymer that can act as a transfection agent once inside a cell.
"We shield, or mask, the positive charge for in vivo use and covalently bind siRNA to the polyconjugate via a disulfide bond," Dr. Lewis explains. "The polymers are directed to specific locations through targeting ligands, for example, n-acetyl galactosamine, that targets the polymer to liver hepatocytes. Through the targeting ligand, the polymer can engage asialo-glycoprotein receptors and be taken up into liver cells via receptor-mediated endocytosis."
In the endosome, the polymer is unmasked and becomes cationic, he says, allowing it to act as a transfection agent. The polymer lyses the endosome, "exposing it to the cytoplasm, a reducing environment that reduces the disulfide bond tethering the siRNA to the polymer and frees it to engage with RISC complexes.
"To date, we have been able to silence apolipoprotein B as well as other target genes in rodents and nonhuman primates, and we envision this technology as a potential delivery system for therapeutic siRNAs," Dr. Lewis adds. "Following apoB siRNA delivery, we have seen a decrease in LDL and serum cholesterol in the animals." In addition, DPC can be delivered by simple intravenous injection in small volumes and does not require injection in potentially harmful large hydrodynamic volumes.
Patricia F. Dimond, Ph.D. ([email protected]
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San Antonio Spurs 102, New Jersey Nets 85 – There's No I in Spurs
PRUDENTIAL CENTER — The San Antonio Spurs beat the New Jersey Nets handily last night by the score of 102-85. The Spurs created off the dribble, got to the line, set up a ton of open looks, dominated the boards and made New Jersey work for every basket.
Manu Ginobili led all scorers with 22 points, including two treys and eight free throws. Parker contributed 13 points and seven dimes. DeJuan Blair did his thing on the boards and Tim Duncan shot well while playing tremendous defense on Brooke Lopez and helping out with three blocks.
Every Spurs player finished with a positive +/- before garbage time. Just like their season, no one player dominated the headlines, but the Spurs were able to win every quarter and come away victorious. The win brings their record to an astounding 46-9. The amazing part is that, despite the record, there still doesn't seem to be much buzz about this team.
It seems that the Heat, Lakers, Celtics, Knicks, Bulls and Nuggets all get more headlines. Even Blake Griffin and the Clippers frequent highlight films. Perhaps even the Thunder and the Jazz garner more press than the Spurs.
The players also don't seem to get the respect a normal team chasing 65-70 wins would normally garner (I guess there is no such thing as a normal team with this record). Manu Ginobili is frequently tabbed as the Spurs' best player, but is only a token entry on many MVP lists. 19 players received more All-Star votes than Manu.
Quite frankly, I would also find it very difficult to argue he should be considered at the very top of MVP lists. (Ginobili greatly challenges our perceptions of player value. Everyone realizes he's one of the best players in the league, but official recognition never measures up to the popular consensus.)
Despite a resurgence, Tony Parker is even further down on this list of All-Star voting, ranking 7th among western conference guards and 31st overall. He would have been a clear choice for All-Star in the East, but in the West he was an afterthought. I can't really disagree too strongly with this assessment either.
As for Tim Duncan, he barely cracked the All-Star team and was perhaps the most controversial selection. I suspect he deserved the slot, but I can't really say that with a lot of conviction either. Despite all these dissenters, few will argue that the Spurs have NOT been the best team this year.
The Spurs have no real MVP candidates and yet they own a record that would usually dictate two or three contenders for the award. Not to worry, Spurs players, there have been other championship teams with "no superstars" that have turned out fine in public perception. The Knicks of the early 70's were considered a team with no elite players. Ironically, this team ended up with more Hall of Famers than any other in NBA history (depending on how you slice it).
If you count Phil Jackson's election as a coach, the 1973 team consisted of seven Hall of Famers (Willis Reed, Dave DeBusschere, Walt Frazier, Earl Monroe, Bill Bradley and Jerry Lucas were the others). No one knew who to credit for that team, so in the end all were rewarded.
The Spurs don't have the "benefit" of playing on a stage like New York City, but I don't think Coach Pop minds. When questioned as to why the Spurs didn't get the most attention, Pop himself suggested more recent champions such as LA and Boston deserved more attention. (He didn't provide a clear explanation for the Heat's popularity, but I think we all know.)
The Spurs this year have been all about team. They have several players who can create their own shots and many more who can rack up points from open treys. Their bigs hustle for offensive rebounds, set screens and look to work in the post when needed. All players graciously accept their role and each puts forth effort defensively.
San Antonio might not get the respect they deserve, but if their winning ways continue through June, the world will be forced to take notice. And, you know, I think they're pretty exciting to watch too.


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Preoperative suspicion of cancer is generally considered a contraindication to LC. However, many patients are found to have benign or pT1a disease, for which LC alone is sufficient. For pT1b or pT2 disease, where nodal metastases are more likely, LC alone is inadequate and portal lymphadenectomy is recommended for staging and tumor clearance. While the role of extended resection of the gallbladder bed for pT1b or pT2 disease can be debated, it is possible that accurate preoperative staging could allow definition of a subset of patients with suspected early-stage GBC in whom a planned initial laparoscopic approach might be reasonable.
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Lewis Black's 'Rant Is Due' Friday at Warner
Lewis Black turns 65 in August, but do not expect him to retire and go gently into that good night.
As long as there are politicians to lambaste and social media to criticize, he'll keep ranting. Plus, he doesn't do anything gently.
"I still won't be seen as an adult in the community, but I'm turning 65," Black said by phone. "I'm reaching the age where I'm looking at the end of the road, going 'What do I really want? What do I want to do, what do I really want?'"
He's thinking about writing a book or play later in the year, and he's determined to finish another television special.
Mostly, though, it's the road he loves. His "The Rant Is Due" excursion finds Black expounding, per usual, on absurdities that tick him off in general and in politics, in particular, like the so-called "fiscal cliff."
"There was a cliff, but don't put us through this nonsense around Christmas time!" he roared. "What kind of Scrooge are you? It's Christmas! Wait until February, when we're in the midst of the flu, to pull this kind of crap."
Lewis reaches the boiling point faster than most Americans, but he sounds especially fed up.
"I don't want (politicians) talking to me. I almost don't want them talking to me ever again," he said. "These people are my age, most of them. And they've learned nothing in their lifetime, except to become the parents that were around when I was a kid. The same group of schmucks."
Black will talk about more than politics. He's unhappy about Facebook and Spotify, a music service.
"When signing on Facebook, I didn't expect to have to see what Tony Pettato -- who I don't even know and have on my friend list only because I don't want to turn anyone down because I don't know (who'll) snap -- is listening to. Are you (kidding) me?
"Then I'm seeing something on my Facebook, an announcement that 'Lewis Black is listening to Adele.' Well, (forget) you. That's my privacy! I don't want people to know I'm listening to Adele. What's the next step? Singing along? That'll come out on the (gosh-dang) Facebook?"
Except he didn't say "forget" or "gosh-dang." Black's strong language matches his strong -- but hilarious -- observations about life's frustrations. He compounds them like interest so the humor hits with snowballing power.
Though Lewis rails more than Amtrak, he acknowledges he's basically a happy, lucky guy, if not happy-go-lucky. He's in a position to raise money for charities that matter to him, such as the 52nd Street Project (which promotes youth involvement in theater) and the Cystic Fibrosis Foundation. He could also win a third Grammy; "In God We Rust" is up for top comedy album.
"I make a really good living at a time when people are getting screwed badly," Black said. "I can, at least, speak out (on) what I think is reprehensible on a daily basis. I get to just say stuff on TV. I can just say what's on my mind; it's like unbelievable. I don't really have to couch it.
"The fact that Erie still exists makes me happy!" he added. "And it's not supposed to be that cold, like in the 40s. I couldn't be happier."


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Thesp to star with Cage, Moore in sci-fi thriller
Jessica Biel is set to star with Nicolas Cage and Julianne Moore in "Next," the sci-fi action thriller based on Philip K. Dick novel "The Golden Man." Lee Tamahori is directing the Gary Goldman script.
Cage will play a man who can see the future and alter its course. Biel will play his love interest, whom he has to save from terrorists. He's on the run from the FBI, which wants to use him to prevent a global terrorist threat.
Biel will take the job after starring in "Home of the Brave," an Irwin Winkler-directed indie in which she plays a young soldier who returns from Iraq and tries to get on with her life with her two children after losing one of her arms in an explosion.
Cage, Todd Garner, Norm Golightly, Graham King and Arne Schmidt are producing "Next."


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Police have locked down some neighborhoods in Boston and its western suburbs as they search for the remaining suspect, who is known as Dzhokhar Tsarnaev, or the man in the white hat from marathon surveillance footage.
The dead suspect was identified as Tamerlan Tsarnaev, 26, born in Russia and the brother of Dzhokhar. Anzor Tsarnaev, the father of the suspects, claims that his son who is still on the loose is a smart and accomplished young man.
"My son is a true angel," he told The Associated Press by telephone from the Russian city of Makhachkala on Friday. "Dzhokhar is a second-year medical student in the U.S. He is such an intelligent boy. We expected him to come on holidays here."
Dzhokar, 19, was born in Kyrgyzstan and in possession of a Massachusetts driver's license.
Law officials told NBC News that both men are legal permanent residents of the U.S., have been here about a year and had military experience.
Authorities urged residents in Watertown, Newton, Waltham, Belmont, Cambridge and the Allston-Brighton neighborhoods of Boston to stay indoors. All mass transit was shut down and businesses were asked not to open Friday. People waiting at bus and subway stops were told to go home.
"We believe this to be a terrorist," said Boston Police Commissioner Ed David of the suspect on the loose. "We believe this to be a man who's come here to kill people. We need to get him in custody."
The Middlesex district attorney said the two men are suspected of killing a Massachusetts Institute of Technology police officer on campus in Cambridge late Thursday, then stealing a car at gunpoint and later releasing its driver unharmed.
Hours earlier, police had released photos of the marathon bombing suspects and asked for the public's help finding them. A new photo of the suspect on the loose was released later showing him in a grey hoodie sweatshirt. It was taken at a 7-Eleven in Cambridge, just across the Charles River from Boston.
Authorities say the suspects threw explosives from the car as police followed it into Watertown. The suspects and police exchanged gunfire, and one of the suspects was critically injured and later died at a hospital while the other escaped.
The FBI said it was working with local authorities to determine what happened.
Doctors at Beth Israel Deaconess Medical Center in Boston where a suspect in the marathon bombings was taken and later died said they treated a man with a possible blast injury and multiple gunshot wounds. They wouldn't say if the patient they treated, who came in with police, was the suspect in the black hat from marathon surveillance footage.
The MIT shooting on the Cambridge campus Thursday night was followed by reports of gunfire and explosions in Watertown, about 10 miles west of Boston.
The MIT officer had been responding to report of a disturbance Thursday night when he was shot multiple times, according to a statement from the Middlesex district attorney's office and Cambridge police. It said there were no other victims.
In Watertown, witnesses reported hearing multiple gunshots and explosions at about 1 a.m. Friday. Dozens of police officers and FBI agents were in the neighborhood and a helicopter circled overhead.
State police spokesman David Procopio said, "The incident in Watertown did involve what we believe to be explosive devices possibly, potentially, being used against the police officers."
Boston cab driver Imran Saif said he was standing on a street corner at a police barricade across from a diner when he heard an explosion.
"I heard a loud boom and then a rapid succession of pop, pop, pop," he said. "It sounded like automatic weapons. And then I heard the second explosion."
He said he could smell something burning and advanced to check it out but area residents at their windows yelled at him, "Hey, it's gunfire! Don't go that way!"
MIT said right after the 10:30 p.m. shooting that police were sweeping the campus in Cambridge and urged people to remain indoors. They urged people urged to stay away from the Stata Center, a mixed-use building with faculty offices, classrooms and a common area.
Hours later, MIT, which has about 11,000 students, said the campus was clear but the shooter was still on the loose.


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Ruth P. Wicker
Aug. 9, 1915- Aug. 10, 2012
Age: 97
Residence: Greeley
Ruth Wicker, 97, of Greeley, died at Bonell Good Samaritan on Aug. 10, 2012. She was born Aug. 9, 1915, to John and Emily (Pfalzer) Lake in Hillside, N.J.
She graduated from Hackettstown High School in Hackettstown, N.J., where she took a business course. She attended Southern Methodist University and University of Northern Colorado music schools and Aims Community College.
She worked as a secretary for several business firms in New Jersey and later did accounting for General Electric, and as a Civil Servant in Army Intelligence at Fort Benning.
On Jan. 30, 1943, she married James Wicker in Alabama. The couple had one son, Larry, who is deceased.
Mrs. Wicker enjoyed playing the piano, dancing with the Greeley Merry Mixers, walking and reading. She gave private piano lessons on her baby grand that took up half of her living room after moving to Greeley in 1974. She did this for many years.
She was involved in many clubs and organizations. She was a member of First United Methodist Church for many years, where she attended Bible classes and played the piano, United Methodist Women, Greeley and the Greeley Area Music Teachers Association.
Ruth lived on 15th Avenue Court in the Hillside area until she broke her hip in 2005. She remarked several times how she began her life in a Hillside and spent many of her years still connected to a Hillside. From the hospital she went to Life Care Center, to The Bridge, to Fair Acres, to the Bee Hive and then to Bonell. She made lots of new friends while playing her beloved piano music at each of these places.
Ruth Wicker is survived by a sister in San Diego and a brother in Bloomfield, N.J.
Her parents; brother; son, Larry; and her husband, James, are deceased.
Services will be held at 11 a.m. Thursday, Aug. 16, 2012, at the Allnutt Macy Chapel. Interment at Linn Grove Cemetery.
Memorial contributions may be made to the First United Methodist Church of Greeley in care of Allnutt Funeral Services, 702 13th St., Greeley, CO 80631.


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You can order these online through the Nintendo homepage
lol when you called the first time did the say "Wii would like to play" when i first called they said that to Mii lol but it was before launchOriginally Posted by haru
You can order these online through the Nintendo homepage
Arguing Over The Internet Is Like Participating In The Special Olympics, Even If You Win You Are Still Retarded.
Super Smash Bros Brawl:
Mario Strikers friend code:
no probOriginally Posted by LevesqueIsKing
:Originally Posted by Damascus
Their 5th tv!
Last edited by Syntax; 11-27-2007 at 08:23 PM.
Wii Hardware: Wii, 2 Controllers, 2 Nunchucks.
Wii Games: Call of Duty 3, Need For Speed Carbon, Need For Speed Prostreet, Super Smash Bros. Brawl (on order), Brain Age,Legend of Zelda Twilight Princess, Wii Sports.
Previous Systems: Sony PSP (still have), Nintendo Gamecube (still have), Nintendo Gameboy Advance SP (still have), Nintendo SNES (still have), Xbox 360 (Had for a month, kept freezing, sold it)
***Car Lover***
wow, i never heard of anyone really actually using the wii wrist straps before.
Spoiler Alert!The world is going to hell and you can too!! And only for $99.99!!!!
i want one of these new ones with the locking-clip
i went on the EU Wii website because im in the UK, filled out the forum for 4 more wrist straps and it says that my serial code has alredy been used,
yes this is true it has been used, but only to request the Wii-Remote-Jackets.
anyone help me out?
do what I did- call nintendo (phone number is in the first post)
If I remember, press 6 at first (for products), then press 3 (to place an order).
ask for 4 (overbuying free stuff is awesome! I only have one wii remote XD) WII CLIP WRIST STRAPS.
I only called as a last resort, as I mentioned. I have to say, the people are pretty nice there.
If you want to add me in Brawl, PM me that you're going to (and include your brawl name and friend code). Also, PM me if you delete me, so I can delete your name, too. I need space, ya know.
For anyone who added me in Brawl and deleted me because it still said "Awaiting Registration", please re-add me. It just means we both haven't been online at the same time.
Haha I haven't used the strap since the night I got my Wii. Free stuff though..might order it.
"We've all been down this path before
You're trapped in this town
And it wears you down
When we leave today maybe you'll understand
That this constant struggle isn't always in the palm of our hands."
i cant as im in the uk and calling a usa number would cost a bombOriginally Posted by Damascus
Wii Hardware: Wii Console, 3x Wiimotes, 1x Nunchucks
Wii Games: Wii Sports, The Legend Of Zelda:TP
PS3 Hardware: PS3 60GB Console, 1x Sixaxis, 1x HDMI 1.3, 1x HDMI 1.2
PS3 Games: Resistance:FOM, Motorstrom, WarHawk, WWE:2008, Blast-Factor, Super-Rub-A-Dub
Since everybody who ordered them got the wii remote jackets or whatever they are called, now we get to play when will my straps get here (yay!)


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Published 18 Apr 2008
READ INDIA …. An Overview Background: First developed by Pratham in 2002, the accelerated reading techniq...
READ INDIA …. An Overview Background: First developed by Pratham in 2002, the accelerated reading techniques (for learning to read and do basic arithmetic), are now running to scale in over a 100 districts of the country making a difference in the lives of over a million children in the age group of 6 - 14. Pratham model focuses on reading as a key activity within the existing school system and providing age appropriate and relevant teaching and learning material for this. Over the last two years, state governments in Madhya Pradesh, Bihar, Karnataka, Andhra Pradesh, and Tamil Nadu have taken up learning to read campaigns on a large scale, in different forms, with the help of Pratham network. These campaigns have led to significant improvement in the reading levels of children and have also generated visible impact on motivation of teachers and educational administrators from the HM to the District Education Officer (DEO). Pratham has ongoing partnerships with state governments in Uttar Pradesh, Himachal Pradesh, Uttaranchal, Nagaland and Orissa. The Problem: A survey to assess the current Status of Education (ASER 2006) was conducted in 28 states in India in the months of October and November. One of the key findings of this survey was that in Std V, 47% children could not even read a Std II text fluently. Specifically, * In Std I, 38.2% cannot read alphabets and 53.7% cannot identify numbers * In Std II, 76.7% cannot read Std I text, and 75.0% cannot do subtraction * In Std V, 47.0% cannot read Std II text, and 54.6% cannot do division. ASER 2006 indicates that half of all children in the country start lagging behind in Std I and continue to lag behind in the achievement of expected competencies in Std III, and Std V. The Solution: Pratham has launched the Read India campaign aimed at achieving reading and arithmetic proficiency for all children in the country within and outside the school system. The focus will be on: * Std I-II : alphabets/words and numbers/place value level. * Std III-V: fluent reading, writing and solving arithmetic problems. Higher standards are not excluded, but will not be the primary focus. Execution: The Campaign will be phased over two years and has to achieve its goals by 31st March 2009. The phasing will be both geographical (propose to target about 300 districts in the first year and the balance in the second year) and sequential within each district (there will be a summer campaign followed up by a low intensity school campaign during the academic year). This campaign will be executed with the help of school teachers, anganwadi workers and volunteers, who will be mobilized and trained by Pratham teams. While the school teachers will be working inside their schools, volunteers and anganwadi workers will be working with children and their mothers outside school, particularly during the summer school preparedness campaign. Read India campaign proposes to introduce a daily period for reading and arithmetic in school using graded learning and teaching materials for children and teachers. Volunteers will also ensure that mothers of such children are involved in their children's learning. Each state will have a Core Group at the state capital, which will be responsible for coordination with government, creation of materials, logistics, accounts, monitoring, evaluation and reporting. Pratham proposes to mobilize volunteers at the village level and appoint coordinators at the cluster, block and district levels. Coordinators at the cluster and block level will coordinate the activities with school teachers, volunteers and anganwadi workers in school / village / community. Pratham has invited the Government of India and all the state governments to be closely involved in this nationwide campaign from April 1, 2007 to March 31, 2009.


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The health of a president can change the attitude of a nation -- or the course, if he dies. Take a look at how healthy some of our past leaders were.
Which presidents were most unhealthyUPDATED 3:59 PM CDT Oct 31, 2012
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