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Thanks to new biomarker data, Scott Patterson signals success in cancer diagnostics.
April 1, 2008 | Four years ago, Amgen created a division of medical sciences. One of the founders was Australian Scott Patterson, an executive director responsible for many of the division's biomarker activities. The group of more than 200 physicians and scientists runs the company's early stage development studies, including the biomarker program, and has produced what Patterson hails as "the new story" in personalized medicine.
It's the story of the oncogene KRAS, its involvement in the epidermal growth factor (EGF) signaling pathway, and the relevance of this biomarker on Vectibix, Amgen's colon cancer drug. Amgen acquired the rights to Vectibix as part of the Immunex acquisition in 2002. The FDA approved the drug in 2006, but its European counterpart initially rejected the drug in early 2007. However by that time, Amgen was discovering compelling new biomarker data: patients with 'normal' KRAS genes tended to respond well to Vectibix, whereas those harboring KRAS mutations derived no benefit from the drug.
Here, Patterson discusses the results, which were first presented at the European Cancer Organization (ECCO) conference in September 2007 and published this month in the Journal of Clinical Oncology, and their implications with Bio-IT World's Kevin Davies.
Bio•IT World: Scott, what is the role of medical sciences within Amgen's drug development program?
Patterson: Four years ago the FDA critical path initiative described the phases of drug development, including a phase called "exploratory." Well, we established medical sciences three months before it came out, and that 'exploratory' phase described what Medical Sciences' remit was - the transition from "R" to "D." We thought we'd do something a little differently at Amgen. Normally you matrix in different components with the early development group - which consists of physician scientists, clinical pharmacologists, and clinical research study managers, the people who design and execute the first-in-human studies. We said, "we want biomarkers to be a component of our early clinical development program, so let's bring in bench lab departments, so that they're working together." Not just early development with matrixed biomarker resources, but actually one function. This function is now led by Brian Kotzin, and I have responsibility for about a third of that function. My department was formed from former functional genomics groups, so genomics and proteomics technologies. Roger Perlmutter, the head of R&D, had said he wasn't really interested in investing in technology for new targets four year ago, but would invest in technology to help develop drugs. And so, we wanted to bring those people in and apply their expertise into drug development.
You also brought in a computational biology group. What does it do?
One way they're involved is in helping us establish the appropriate way to get the assays run and the data analyzed. As an example, they introduced "design of experiments," which is a paradigm that's applied to understanding assay performance characteristics. If you want to run the complete matrix of the different parameters that you'd want to explore to understand your assay, it takes a long time. A smarter way to do it is called "design of experiments." This computational approach picks out different components you want to explore, making for an efficient assay qualification process... We're making [clinical] decisions so they have to be very robust assays. They help us with the analysis of the data as well. They're also involved in experimental design and analysis when we're doing discovery for biomarkers because we're still using, in some cases, 'omics technologies. So we need that expertise for mass spec data and microarray experiments.
What's so special about the Vectibix biomarker story?
Vectibix was part of the Immunex acquisition, so it was already in development before we even set up medical sciences. Vectibix received accelerated approval in the U.S. for refractory metastatic colorectal cancer patients in third-line therapy as a monotherapy with best supportive care in September 2006. But with the KRAS biomarker data, it's an exemplar for oncology development now. It is the example of personalized medicine. We've known about Herceptin for ten years, but this is new. The KRAS biomarker data is what's really showing how you can now look at the effect of a mutation downstream of a targeted receptor to define a patient population.
Are you saying this is the gold standard now for personalized medicine?
Yes, this is a prime case study for personalized medicine in oncology. This is the new story on the block... So, Vectibix (or Panitumumab) is a fully human monoclonal antibody that blocks binding of the ligand to the EGF receptor (EGFR). In our clinical trials, approximately 10% of patients responded to the therapy - they had tumors that were primarily driven through the EGFR pathway...
Thirty years ago, oncogenic mutations were discovered in RAS. It's known as a poor prognostic factor. So, if you have KRAS mutations, that's not good for disease progression. The theory was, if we have activating mutations of KRAS, then blockade of the receptor upstream would be irrelevant. Therefore, if you have a KRAS mutant population, then they won't respond to the therapeutic, so that'll be a negative predictor...
We knew it was a smaller percentage of patients who were responding, we had to try to understand the strata within the population. So, we and others began to assay samples from Phase 2 studies, and it looked like there were no KRAS mutant samples from patients in the population responding to anti-EGFR antibodies, which is what we were expecting. We then confirmed these findings in the pivotal Phase 3 randomized trial. KRAS mutation frequency in colorectal cancer is around 50%, reported ranges are 30 to 57%.
How do you do test for the KRAS biomarker?
We ended up running the [Manchester-based] DxS assay - an allele-specific PCR-based assay which uses their amplification refractory mutation system (ARMS), that essentially amplifies only mutant alleles, so very high sensitivity [is achieved] in a background of wild-type DNA... Whenever you have the tumor that's excised, and it's put into a [paraffin] block format and then you take sections, not all the tissue is tumor tissue. If you want to do direct sequencing - PCR-amplify a region and do population-based sequencing - you need to remove all of the normal tissue because of sequencing sensitivity... We don't need to that with the DxS assay. There has to be a minimum amount of tumor, but we don't have to go in there and remove normal tissue because of the 1% sensitivity, whereas with direct sequencing, it's got to be more than 20%.
[By then,] we'd also submitted Vectibix for approval in the E.U. In March 2007, the EMEA came back with a negative opinion, said it doesn't really look good enough guys. We were just poised to run our samples... We established a pre-specified data analysis plan, ran the samples at a Belgian CRO (HistoGeneX), data came in and were analyzed. When we submitted the data to the CHMP [Committee for Medicinal Products for Human Use] at EMEA to review, they gave us a positive opinion... So we got conditional approval in metastatic colorectal cancer for Vectibix in wild-type KRAS patients.
Was the EMEA's earlier rejection because your positive responders were masked by the non-responders?
Yeah, I presume that was their basis. Importantly, the [KRAS] mutation frequency in our pivotal trial was 43%, pretty much what everybody sees. So it's pretty simple: half of them are KRAS mutant, half are wild types - you essentially double your response rate, thereby increasing the benefit to risk ratio through exclusion of non-responders.
All of the benefit resides in wild-type Panitumumab-treated [patients]. You couldn't dream of a better result! But statistically speaking, it's a negative predictor. We're predicting non-response... The responders are in the wild-type population, but there are also some non-responders there. So, we're continuing to try to see if we can chip away at this. What other pathways are affected? Is it loss of PTEN? Activating PI3 kinase mutations? Is it over expression of the ligand? ...
For a company whose mission statement is to serve patients, [we're] really living up to the mission statement because we don't want to have the drug given to patients, exposed to the drug, who can't respond, who have no likelihood of response. And this essentially takes out 50% of the population.
One of the conditions of approval in the E.U. was that there was a CE-Marked test kit available. The EMEA doesn't specify a test kit, but we wanted us to make sure there was one available, so we worked with DxS to ensure that they had their test CE-Marked in 22 countries. Obviously we want this in the U.S. So, we've presented this data to the FDA and we're working with DxS and the FDA so that this test can eventually be approved [in the U.S.]
The FDA originally approved the drug without any patient stratification data. Don't your corporate colleagues feel a little ambivalent about reducing the target population?Nobody feels good about the drug being delivered to people who haven't got a chance of responding. So, we're just in the stages of discussing with the FDA and DxS to determine the best approach to share this information with prescribers.
For the wild type patients, what's the average clinical benefit to the drug?
One of the things that you'd always like to see is overall survival, but in this trial, because the patients who were on the best supportive care alone were allowed to crossover to the Panitumumab arm once they had progressed, it's very difficult to get overall survival data... So it's not really ethical to leave patients on the control arm when they've progressed.
What has been the early response of the cancer community?
They were really pleased to hear about it. The drug is now launched in the E.U. Tests are available. Interestingly, a lot of hospitals in the E.U. have been sequencing KRAS anyway. In Austria, they've been doing it for ten years. So, they didn't need a kit sort of forced upon them to do this analysis, but the EMEA wanted to make sure there was a kit available... M.D. Anderson, Harvard, Cleveland Clinic all have KRAS testing capability. Genzyme does, for example, but it was for lung cancer. But I'm sure they'll have a colorectal cancer test...
It sounds similar to the EGFR/Iressa story in lung cancer (See, "Minority Report," Bio•IT World, June 2004), in a way the answer was right there in front of people?
Well, people have said, "You knew it for 20 years, why wasn't this a stratification factor?" Pre-clinically it didn't really work out that way, which was surprising. And we knew it was a poor prognostic factor, so it's difficult to tease apart prognostic implications from the predictive implications. And this is the first randomized controlled trial showing this data and it's so clear...
This is one of the reasons we set up medical sciences. We're now working on [oncology, inflammation, and metabolic] programs to get ahead of the game. We would much prefer to define the potential diagnostic before we go into Phase 3, so that we would have the initial stages of validation of the kit accepted by the FDA. We'd be randomizing patients on that basis. We may still be putting positive and negative biomarker patients into the trial, but the hope is you'd complete your trial, your response data would look good, [and] your companion diagnostic would get approved at the same time. That's what the FDA would love. That's what we'd love. Unfortunately, you don't always know enough physiology going in.
Further Reading: Amado, R.G. et al. J. Clin. Onc. 2008: April 1
The EGFR signaling pathway. Inhibition of EGFR can halt tumor growth, but not in the presence of activating KRAS mutations.
This article appeared in Bio-IT World Magazine.
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The rating on DCP Midstream LLC reflects the company's satisfactory business risk profile and intermediate financial risk profile. Its strong competitive position within a diverse set of production basins, financial flexibility in a low commodity price environment, and some resilience to weakening commodity prices as evidenced by the company's low break-even commodity price deck support DCP's business risk profile. The company's significant exposure to changing commodity prices and potential cash flow volatility partially offset these strengths. DCP is a joint venture owned 50% by Spectra Energy Corp. (BBB+/Stable/--) and 50% by ConocoPhillips (A/Stable/A-1). DCP's strong competitive position reflects geographic diversity and the significant size and scale of its operations. DCP has a presence in most of the major natural gas...
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DCP Midstream LLC

subset: commoncrawl


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Outside Looking In: What people outside Alabama are saying about the state:
• Alcohol sellers are restricted like no other business when they want to make sales across state lines, says David White, founder and editor of the wine blog Terroirist. "Alabama oenophiles can order wine only from an out-of-state producer if they have received written approval from the state's Beverage Control Board," writes White in The New York Times.
• Maybe those rules are what's making the state so unpeaceful. Alabama ranked 46th -- or fifth least peaceful, according to the Australia-based Institute of Economics and Peace. The institute based its results on "five 'basic indicators' on a per-capita basis: the amount of violent crime, the number of homicides, the number of people in jail or prison, the number of police and other law enforcement statistics, plus the availability of firearms," notes The Washington Times. The findings say Alabama is 9.8 percent less peaceful than it was 20 years ago. Now we feel like a drink.
Join the conversation by clicking to comment or e-mail Richter at firstname.lastname@example.com.


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Pre-paleo, I ate many carbs but zero refined sugar or sweet things.
I went paleo, and had the most extreme sugar cravings i've ever felt!
this seems explainable when you understand that any carbs, be it pasta, table sugar, potatos etc, basically all get turned into glucose. I'm guessing my body wanted glucose and probably knew enacting sugar cravings would be the easiest way to get me to ingest some glucose.
satiety sure seems to help in curbing any sweet desires.


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A faith group supporting Democrat Barack Obama for president has launched new ads on Christian radio stations.
CBN News Senior National Correspondent David Brody gave insight on the ads. Click play for his comments.
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For Women Who Want The Ballerific Life!
In 2012 Angela Stanton was known for putting folks on blast and airing dirty laundry of those who needed airing. Media outles from Vibe, Sister 2 Sister, TMZ, 100.3 The Beat in Philly, Hip Hop Inquirer and others covered the story of Angela Stanton and Phaedra Parks.
In her memoir LIes of a Real Housewife Angela dishes on her past life of abuse, crime and those who played roles in the two. including Phaedra and Apollo.
Angela Stanton has gone through a rollercoaster ride of emotions watching folks get away with bad things while she served time in prison and they moved into a level of success. In her memoir Lies of a Real Housewife Stanton recounts being part of an illegal ring in which Real Housewives of Atlanta co-star Phaedra Parks allegedly mastermind. You can read bout that HERE.
You may remember her coming forward and speaking on Deion Sanders' relationship with her 19 year old daughter, but in 2013 Angela is kicking off her forgiveness and redemption season.
Stanton is shifting gears and taking her experiences penned in her memoir and using them to help others. Here she offers tips on how we can move past the hurt from those who did us dirty.
Stay tuned because we'll be giving away a copy of the book soon!
Views: 2745
Its a good thing yall gone give it away cause I wont be buying that s***, so tired of tell all's . If you actively participate in a crime and not tricked into it and get caught keep your mouth closed cause you knew what you were doing
Oooo this tea.


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A little known piece of the museum's history is that the art collection was the principal reason cited in the House of Lords to acquire the Bethlem Hospital building in Lambeth, which is now the IWM London site.Read More
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Here in the Department of Research, one of my responsibilities is to oversee the development of new content for The Holocaust Exhibition. My next is to display a collection of recently acquired photographs of Roma and Sinti ('Gypsies').
Roma and Sinti were targeted by the Nazis in their discriminatory laws and policies from 1933. They were later subject to slave labour, internment and mass murder (including at extermination camps such as Auschwitz-Birkenau). 25%, or up to 220,000 of Europe's Roma were killed by the Nazis.Read More


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Two charged with vandalismApril 03,2013Two men charged
with Jeep damage
WEST RUTLAND Two men are facing charges they smashed the windows of a parked vehicle.
Vermont State Police responded to Marble Street on March 19 to investigate a report of vandalism. Police found a Jeep Cherokee with all of its windows broken, except for the windshield and drivers-side window.
After interviewing witnesses, police charged Corey Fitzgerald, 21, of Poultney, and Nicholas Greene, 19, of West Rutland with unlawful mischief. Police said Fitzgerald will answer the charge April 22 and Greene will enter a plea April 29 in Rutland criminal court.MORE IN This Just InBENNINGTON A Bondville woman is facing a felony charge after police said they learned she was... Full StoryBENNINGTON A local man is facing up to 50 years in jail after being arraigned earlier this... Full StoryVermont leaders face many policy challenges, chief among them demographics change, according to... Full Story
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Angeline Pinot Noir California
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Angeline Pinot Noir California
Producer: Angeline
Style: Red Wine
Grape Type: Pinot Noir
Origin: California
Region: Other California
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Your Rating & Review
52 Member RatingsAverage Member Rating: 3.86 out of 5 stars
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Member Notes
Very good
by Murphy13733230
Very good if you like smooth, no acid, no spice, not heavy, fruity. I liked it alot, will buy more.
Absolutly Thrilling
by LTJH525
I have truly fallin in love with the Angeline brand. I was thrilled with the 2009 vintage because as u may know Pinot Noir is very temperamental grape, and this vintage was on the mark. Enjoy!
Old Wine Guy
by CONOVER12833498
Great Pinot, smooth,slightly fruity. Excellent as a before dinner wine w/ appetizers. My wife loves it, so it must be good.
Excellent Pinot
by Siegel13469608
For the price, this is a wonderful Pinot. Great fruit and finish. This wine is good with or without food. Served it with grilled Halibut Fillets, excellent.
a little pricey but v good pinot
by Yager12418632
had it 12-4-08 w/ chix. 06 and 07 russian river pinot is all good.
Pretty and has an ending!
by Klebicki13971567
Great Pinot! Price is right!
2007 Vintage
by Whitman13969509
Good Pinot but had somewhat of a bite/ burn but good after-taste. Ate with cheese & crackers.
Better with time
by Divvy23
Hubby purchased this for me with little to no wine knowledge, other than what varietal I like. Total Wines in River Edge has it rated well and at a decent price. It opens a bit sharp, but after a short while softens and becomes a little more fruity with a slight bite and dryness. Quite enjoyable and will definitely purchase again.
very nice Pinot
by Costilow12986508
fruity, smooth, well priced Pinot. It went well with grilled teriyaki chops
cant argue with the price
by kapp12885179
a bit light and has a bite but for the price--can't beat it.
Nice and light
by Hall13612625
Wife's fave. I like. nice frut and soft touch.
This Pinot stands apart
by Spanish Bob
4-1/2 stars. Very drinkable, medium bodied Pinot with a silky smooth feel and great cherry and spice on the nose. Very smooth tannins and just a hint of oak. More complex than most other Pinots in this price range and well worth the money. Buy this!
Angeline Pinot Noir
by Evanoff13394873
Great wine for the price
Great wine for price
by Sorrentino13365445
For $14.99, an outstanding value for Pinot Noir. Highly recommended by staff.
herb and wine lady
by OConnor13027623
I usually find Pinot Noir's to be a bit too light for my tastes, but while at a cocktail party this was served and I must say I was very impressed with the taste and ease in drinking this wine...It is a bit fruitier than I like but if you let it sit for a few minutes that seems to calm down...
favorite Pinot Noir
by Newman12728799
This is our favorite Pinot Noir. Nice wine at a good price.
by Eble11944426
candied cherry-berry, smooth, a bit sweet


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Is this a WK or WJ?
Picture #4 provides the closest view:
Re: Is this a WK or WJ?
Re: Is this a WK or WJ?
WJ. The rims confirm it
Re: Is this a WK or WJ?
I'd say the molding at the bottom of the doors is a dead ringer for WJ.
Re: Is this a WK or WJ?
Wj, hopefully everyone ends up ok
Re: Is this a WK or WJ?
Yes, I hope so too.
Thanks guys!
Re: Is this a WK or WJ?
WJ for sure.
And that accident is in the same town I live in!...:eek:
Re: Is this a WK or WJ?
even though there is a lot of plastic on the wj it looks like it did a good job protecting the occupants though. by the looks of it, it looks like an 01. in 01 they updated the seats and in 02 they added side curtain airbags. which i don't believe from the photos it had. also it had the cross rails on the roof rack, these were standard on all the models up to 01 and in 02 they made it optional.
Re: Is this a WK or WJ?
1 Attachment(s)
def wj, looks just like my old one. They should be ok, I ended upside down and only hurt myself crawling out the smashed window.
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Frappuccino, the Way I Do It (Starbucks Copycat!)
Total Time
Prep 2 mins
Cook 1 min
All it took was exam stress to create this. Tastes like starbucks, but much cheaper! To be honest, all the ingredient sizes are approximate...
Ingredients Nutrition
- 1 teaspoon instant coffee granules
- 3 teaspoons hot cocoa mix (add more if you wish)
- 2 tablespoons hot water
- 2 teaspoons caramel sauce (recipe #243893) or 2 teaspoons dulce de leche (Good Eats Dulce De Leche)
- 3⁄4 cup skim milk (cold)
- combine the coffee granules and hot cocoa mix in a mug.
- Add the hot water and stir to dissolve.
- Stir in the Dulce De Leche or Caramel Sauce. Make sure it fully dissolves into the coffee!
- Top with skim milk, stir once again, and drink.
- You can chill it I guess, but I never do, it just goes straight down.
- For aesthetics sake I guess you can strain out any undissolved bits, but I'm way too lazy :P.
Most Helpful
WOW oh WOW is this good! I am addicted to Starbucks iced coffees - but they sure add up quickly! I decided to try this and am honestly blown away. It's the closest replacement I found. I also love that you don't have to get out a blender! I took Mikekey's advice and added 2 ice cubes. THIS is a keeper! Thank you so (so!) much for sharing this one.
Tastes like the real thing! I also like that I didn't have to haul out the blender and try to blend ice cubes with it, although I added 2 ice cubes to the drink to chill it more. I used decaf coffee granules, since I like these types of drinks in the afternoon, but don't want the caffeine. Made for Fall 2012 PAC game.
This was pretty good. I used a 25 cal pkg of hot chocolate and sugar free carmel all for around 150 calories and no added sugar. I also added a full cup of skim milk instead of the 3/4c. It was a good pick me up for that mid. afternoon drag.


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SHE is keeping an eye on the Big Brother house while carrying on a conversation with her neighbour about something completely different. The rhythmic click of her knitting needles pauses momentarily as she reaches for a newspaper - "that lassie's first out, you wait and see".
While the needles have stopped, she gives a cursory glance down, where a symmetrical nine-point star frames the centre of her handiwork: "Anyway, if we do trade the Mondeo in, I've told Bob a hatchback would be better this time."
You find yourself watching, fascinated, as she plonks the knitting more centrally in her lap and carries on talking. A smaller, cream, brown and blue nine-point star can now be seen in the centre of the outer one. They are different shapes, and the outer one has burgundy in it.
On closer examination, so does the inner one - it's just that the colours are combined differently. The coloured yarns, housed in old coffee tins with holes through the lids, roll gently round her feet as the wool feeds through. There are no written instructions in evidence anywhere.
Ellen can't understand why anybody should be remotely interested in what to her is a standard piece of knitting. A pattern, she reckons, is a lot less hassle than a plain job. "The pattern hides all the workings, so you don't have to be so fussy. Anyway, with the blue and the burgundy, it matches two jackets instead of one," she explains.
Mathematician Mary Harris, attached to University College London, looks at it somewhat differently. "Ellen is actually producing an Archimedean spiral. She knows exactly when and where to decrease' and the precise number of stitches she needs to lose at certain places, so the work takes on the exact shape needed for the purpose," she says.
"Experience has taught that it's no good thumping a piece of lumpy knitting with an iron. As she says, she's concealing the adaptations to the shape by incorporating the changes into a symmetrical pattern.
"She's doing that by changing the colour of her yarn systematically as she goes along."
There's nothing unique about Ellen - yet. But she's a product of her time, and that time has gone. Subsequent generations, dismissing what women like Ellen do as "granny's knitting", have obviously never tried it, says Ms Harris.
She explains: "In mathematical terms, Ellen has worked a band of translational symmetry with two alternating motifs on a reducing number of units, until another strip pattern takes up the journey to the centre of the spiral where she changes to another pattern - the star with nine-point symmetry. Working from the circumference in, she's produced a geometrically perfect dome-shaped design."
It's the equivalent of conducting a symphony without a score. As far as Ellen's concerned, she's knitted a beret that matches two jackets. If it fits, that's fine. End of story.
Maths does not feature because she never did maths at school. "Maths classes were for the clever folk, not the likes of me," she laughs.
It's the kind of remark that lights blue touch paper under Ms Harris, who was originally trained as a scientist, but who has spent almost a quarter of a century trying to bridge the gap between school maths and maths in the real world outside the classroom.
"The reason Ellen can do what she does is because she doesn't associate it with maths," she says. "This is because people like her were pre-conditioned into believing that maths was not for them.
"If someone had told her all these years ago that she was mentally calculating and adjusting complex mathematical formulas she would have decided there and then that she couldn't knit to save her life, and turned her talents to sewing."
Maths, says Ms Harris, is still looked on as a subject connected with high status technologies - an assumption that led her to front a recent "Maths in Work" project.
Carried out through the University of London's Institute of Education, it was aimed at encouraging teachers to use crafts and textiles as a basis for learning mathematics.
The project involved Ms Harris and a team of colleagues travelling to different areas in the UK. Among the talks and lectures were public workshops to which the team invited lecturers, mathematicians, teachers, members of women's institutes and people involved in trades, crafts and textiles.
Those attending were asked to try to work out the answers to some practical mathematical problems - the structure of a garment to fit someone's head, a simple knitted jumper to fit themselves, using ten stitches to the inch, or fitting non-wrinkly lagging on a right-angled pipe.
Inevitably, says Ms Harris, the academics over-complicated everything. When asked to explain verbally what they were doing, they were typically completely stumped.
On one memorable occasion, a women's institute stalwart stood up and silenced a teacher who was carrying out a long and laboured breakdown of the pipe-lagging problem.
"Oh for pity's sake lad, all you're doing is turning a heel on a bleddy sock."
On a different occasion, another woman was seen helping out somebody struggling to work out the simple sweater design.
"Your armholes won't fit the top of your sleeves because you've got too many stitches, but if you just decrease by two at the end of every tenth row till you've got 80 stitches, they should match."
She denied she'd just done some pretty impressive on-the-spot mathematical calculating. She couldn't possibly, she insisted, because she couldn't do maths - her husband was always telling her so.
"Knitting patterns are a form of algebra," says Ms Harris, "and their real use is to set up the beginnings of the motifs within a particular number of stitches.
"Once that's established, a knitter will usually abandon the pattern as their own thinking takes over."
Real knitters communicate in the same sort of algebra that a pattern uses, she says. It's a skill that translates into a myriad of shorthand forms, according to the particular family or group of people passing them on.
It's just not something that can be compartmentalised and presented in the formalised way that mathematicians seem to need - which is why they can't deal with it. Meanwhile, the Ellens of this world invent and reinvent as they go along, according to whether the intended wearer has long arms and a short waist, is flat-chested or has a bum that will undoubtedly look big in it - if the ribbing at the bottom isn't subtly increased.
They can be found all around the country, rattling off garments that the recipients will often take at face value and consign to the back of a drawer, without realising they probably own a unique and finely-crafted example of transformation geometry.
Treasure these gifts, says Ms Harris. Hand them down as heirlooms and give the mathematicians of tomorrow something to think about.


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Hegel Music Systems HD2, HD10, and HD20 DACs
Hegel Music Systems was on hand to show off their ever-expanding range of DACs. The smallest sitting at the top right is the $350 HD2 USB "music streamer" that can handle 24bit/96kHz USB data and output it either as analog audio or digital data over SPDIF.
Under the HD2 is the $1,200 HD10 which offers USB, coax and optical digital inputs as well as both balanced and unbalanced outputs. To the left of the HD10 is the newest DAC from Hegel, the HD20, which in addition to the inputs and 24/192 conversion found on the HD10, offers remote control and display for $2,000.


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Environmental Lab Equipment Companies serving Yemen
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MACHEREY-NAGEL is a globally operating company with stable growth. In the recent years, the annual turnover exceeded 100 million Euros. Our comprehensive portfolio includes products for Filtration, Rapid Tests, Water Analysis, Chromatography, and Bioanalysis. We are proud to carry more than 20,000 products designed and manufactured to fit your individual needs. With more ...
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BHS-Sonthofen GmbH, headquartered in Sonthofen / Germany, is an owner-operated group of companies in the field of machine and plant engineering. The company offers technical solutions in the field of mechanical process engineering, with a focus on mixing, crushing, recycling and filtration. With over 300 employees and a number of subsidiaries, BHS-Sonthofen has a global ...
Ashtead Technology Ltd
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Ashtead Technology was formed in 1985 when Ashtead Group plc acquired SubSpek Limited, which at the time provided underwater positioning, survey and inspection equipment rental from a base in Aberdeen. In 1994 the Singapore base was opened, focussing on the offshore oil and gas industry and the subsea telecommunications cable market in Asia Pacific. The first US ...
Heraeus Noblelight LLC
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Heraeus Noblelight counts itself among the market and technology leaders worldwide for special lamps with wavelengths from ultraviolet to infrared for industrial, scientific, and medical applications. With locations in Germany, the United Kingdom, China, and the USA, the segment manufactures lamps for analytical measurement technology and the printing industry, infrared ...
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The return of Evan Turner and Lavoy Allen was a little more competitive than expected.
The struggling 76ers gave the Eastern Conference leading Pacers a contest before Indiana escaped with a 101-94 victory Friday night at the Wells Fargo Center.
This marked the 19th consecutive loss for the Sixers (15-50). A setback Saturday night at home will tie the franchise-record of 20 straight defeats rung up by infamous 1972-73 squad.
The NBA record for consecutive losses is 26 by the 2010-11 Cleveland Cavaliers.
If the Sixers are looking for sympathy, they won't get it from Allen. They traded the big man and Turner to the Pacers (48-17) for Danny Granger and Golden State's 2015 second-round pick.


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Student Resources
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NIC to sponsor first ever North Idaho adventure race
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North Idaho College's Student Activities Department will sponsor the inaugural NIChallenge, an adventure race Saturday, May 7 at Farragut State Park.
NIC's Outdoor Pursuits program is helping to coordinate the event, which is the first ever to be held in North Idaho.
"I think the closest other regular adventure race is in Leavenworth, Wash.," said Outdoor Pursuits Coordinator Paul Chivvis. "This is a relatively new form of race that focuses on teams and fun and NIC is proud to bring this opportunity to racers and outdoors enthusiasts in North Idaho."
Chivvis, Outdoor Pursuits Assistant Coordinator Jon Totten, Associated Students of NIC Vice President Emily Compton and former Computer Services employee Brad Yoder entered the Washington adventure race last year to get firsthand experience of the sport to see if it was feasible to organize a race in Coeur d'Alene.
"Adventure racing is challenging, but it's also a lot of fun, so we have no doubt that there will be a lot of people here interested in participating," Chivvis said.
Adventure racing is a multiple-sport race based on teamwork and designed to test the limits of competitors. Races often include kayaking or canoeing, trekking, mountain biking, and an orienteering or problem solving obstacle that must be completed along the team-navigated course, which ranges from 20 to 300 miles and 3 hours to four days in length depending on the race.
The NIChallenge is a sprint adventure race that incorporates 10 to 15 miles of mountain biking, four to six miles of trail running and two to five miles of paddling and basic navigation as well as obstacles to test teamwork and physical and mental skills. Specific details of the NIChallenge course will not be released until race day to ensure that participants retain their sense of adventure, according to Chivvis.
The race is part of the Challenge Adventure Race Series offered in western Washington and is cosponsored by Fleet Feet Sports, Two Wheeler Dealer, Mountain View Cycle and Mountain Gear.
Teams of two or four members (co-ed, all-male or all female) must register by Sunday, May 1. Cost is $75 per person and includes a capilene shirt from Patagonia, food at the event and the opportunity to win various prizes.
or in person at the Outdoor Pursuits Office, located on the lower level of NIC's Edminster Student Union Building.
Information: (208) 769-7809.
For More Information
NIC Outdoor Pursuits Coordinator Paul Chivvis, (208) 769-7809
Posted: Monday, April 4, 2005
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"The Yes I Can students focus on learning about disabilities, how to help others, self determination, goal setting, teamwork and appreciation of diversity," Lamedman said.
It is obvious Lamedman inspires every student in her class to strive to be their best. It is also apparent that all her students bring special qualities that help turn Lamedman's Yes I Can class into a dynamic family.
Yes I Can is known as a social inclusion program for students with and without disabilities. It was developed at the University of Minnesota to help destroy the barriers that may surround junior high and high school students with mental and physical disabilities.
The Yes I Can program was brought to the William S. Hart Union High School District and other Santa Clarita districts nine years ago and has been a part of Canyon for eight years.
Needless to say, it has been an immense success. Yes I Can not only teaches respect for all levels of diversity, but also builds amazing character in students and creates strong friendships.
Junior Ryan Leimbach described Yes I Can as, "All-around awesome. It teaches all the differences about people."
When asked what he liked most about Yes I Can, junior Dante Balardinelli said, "Yes I Can unifies all people, no matter (their) race, ability levels or religion. It taught me how to treat people as people."
Senior Darren Monroe explained, "Everybody and everyone can come together and be one."
Junior Luke Stockner said enthusiastically, "I wish I could have joined in ninth grade."
"When people hear about Yes I Can they ask, 'What's up with that?' They don't understand what it is about," said senior Riley Powers, a Yes I Can student.
Many have heard of Yes I Can but few know what the class is really about. It is often misunderstood as simply a class for students with disabilities, but the program achieves so much more.
"Open Your Mind" is one of the slogans for Yes I Can, a year-long elective that can be taken at Canyon and other Hart district high schools. The class combines students with disabilities and general-education students, and both groups benefit from the social interaction.
Lamedman and every Yes I Can student will agree that the most exciting and empowering thing about Yes I Can is the annual Summer Meltdown Autism Awareness and Social Inclusion Concert.
Produced by the students under the guidance of Bret Lieberman, the Yes I Can advisor at Golden Valley High, this concert has been held every summer for the past six years at Golden Valley's outdoor amphitheater, and each time has brought the concept of unity through music to reality.
A dozen or more bands are able to perform and all proceeds go to help defray the cost of producing Summer Meltdown.
It takes $20,000 to $30,000 to produce the festival, so Yes I Can holds many fundraisers through the fall, winter and spring, from food nights at local restaurants to fun days at Mountasia to selling T-shirts. Many local sponsors also contribute to the cause by providing merchandise for giveaways and covering other costs.
At the last Summer Meltdown, students had the pleasure of seeing the very popular rock/hip hop duo Shwayze and will see them again this summer for the seventh annual Meltdown concert in May 2010. Cisco Adler of Shwayze said, "This is our second Meltdown of many. I love to rock out for a good cause!"
Coincidentally, Cisco's parents, Page Hannah-Adler and Lou Adler, founded a camp for seriously ill children called The Painted Turtle in Lake Hughes, the only camp of its kind on the West Coast to provide safe and fun experiences for children with serious or terminal illnesses.
Seeing as Lamedman provides such great encouragement and inspiration to her students, when asked who her greatest inspiration was she exclaimed, "Riley Weinstein is my hero. Not many people thought she was capable of much because of her physical disability but she proved them wrong."
Today's generation of students often gets caught up in dealing with our own issues and problems, and forget about the well-being of others. There is definitely something so inspirational and heroic about the Yes I Can family; it serves as a humble reminder that we all live together so we should all enjoy each other's company with as little negativity as possible.
Dr. Seuss once said, "Unless someone like you cares a whole awful lot, nothing is going to get better. It's not." This is the philosophy that Yes I Can lives by and this philosophy will help to eventually eliminate judgment and stereotypes from the world.
For Yes I Can and Summer Meltdown fundraising and event updates, visit www.myspace.com/yesicaneducation, call Ms. Lamedman at Canyon High at (661) 252-6110, or phone Mr. Lieberman at Golden Valley at (661) 298-8140 ext. 1414.
Juliana Menchaca is a student at Canyon High School.


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NEWARK — Local activists took Nelson Mandela's legacy to the streets of downtown Newark today, calling on holiday shoppers to carry on the late South African leader's struggle for equality as part of global fight that had also been taken up by African Americans.
Three dozen members of the People's Organization for Progress rallied near Newark's main intersection at the corner of at Market and Broad streets, as the group's founder, Lawrence Hamm exhorted passers-by and a mostly black crowd gathered around a nearby bus shelter to keep the dream of equality alive. The group then marched west, toward City Hall, carrying signs reading "We Remember Nelson Mandela" and "If there is no struggle, there is no progress."
Mandela, the icon with the impish grin who served 27 years in a South African prison for trying to end apartheid before becoming the country's first democratically elected president in 1994, died on Thursday at age 95.
"Nelson Mandela did all that he could do," Hamm, bundled against the cold, shouted through a bull horn, noting that poverty, unemployment and other ills still plague many black South Africans after centuries of official and unofficial oppression. "His job was to abolish the apartheid regime and he did that, but the people of South Africa are still suffering,"
"The best tribute that we can pay to Nelson Mandela is to build that struggle in this county, to finish the unfinished work of Martin Luther King, to finish the unfinished work of Malcolm X," Hamm said.
Some of the people waiting on the corner just after 2 p.m. barely took heed. Others watched and listened until it was time to board their bus.
"I think it makes sense," 27-year-old Kaydeian Manning, a native of Jamaica who lives in Irvington, said of Hamm's desire to link the South African and American civil rights struggles. Praising Mandela, she added, "He's shown us no matter how long it takes, it's possible as long as you have hope."
• South African leader Nelson Mandela dead at 95
• Nelson Mandela's death: Reactions from political and civic leaders


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The journal serves as a platform for theoretical and methodological articles as well as empirical studies on the history of concepts and their social, political, and cultural contexts. It aims to promote the dialogue between the history of concepts and other disciplines, such as intellectual history, history of knowledge and science, linguistics, translation studies, history of political thought and discourse analysis.
Article submissions:
The Editors welcome submissions for publication consideration. Please refer to the journal?s website for full submission requirements and style guidelines:
E-mail submissions of articles to: email@example.com
Editors: Margrit Pernau, Max Planck Institute for Human Development, Berlin
Sinai Rusinek, the Van Leer Jerusalem Institute
Assistant editor: Jani Marjanen
Associate editor: Joao Feres Jr.
Editorial assistant: Ilana Brown


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Fun Places
Tom Heyman
Alternative Folk
Former Go to Blazes frontman Tom Heyman has earned favorable comparisons to Johnny Cash, with a similarly deep, clipped baritone and songs filled with sin and misadventure. When speaking of Boarding House Rules, however, Heyman would seem to have more in common with Joe Henry, whose dark and dry tales (particularly of the early '90s) rank among the best alt-country ever recorded. Heyman sings in varying forms about drinking, its medicinal effects at numbing an agonized life ("Eggs and Whiskey"), and its power to destroy ("Sixteen Blocks to Go"). Heyman has no doubt at some time in his life worked some kind (or series) of night jobs, as the nocturn plays a strong role in his unrepentant songs: a drunken factory worker, a gravedigger who hides in his job's solitude, a man who drives all night to see a lover he knows he won't be true to. Also like Henry (and unlike Cash for the most part), Heyman's characters (the drunk, the addict, the arrogant) find no redemption, no escape, their lives go on unaffected. John Duffy
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HOUSTON - A Houston area school superintendent won't be reprimanded for failing to disclose she is a paid consultant for an energy conservation company that she recommended the Spring Branch Independent School District hire, the school board's president said.
Yvonne Katz recommended the district sign a contract with Energy Education Inc., a Wichita Falls-based company, shortly after she was hired as superintendent in 2002. She earns $250,000 a year as Spring Branch superintendent.
Energy Education stands to make millions based on its contract with the district, the Houston Chronicle reported in Tuesday's editions. The company develops specific energy-saving plans for districts and trains employees on how to make the plan work.
School board President Wayne Schaper said Energy Education has a "proven track record" of saving school district and taxpayer money.
"Being a taxpayer, it's no big deal to me," Schaper said referring to Katz's failure to disclose her ties to the company. "But I would like to know in the future."
Schaper said the school board may amend Katz's contract to require disclosure if someone she consults for wishes to do business with the district.
Katz earns $500 each time she arranges a meeting between the company and leaders at a school. She told the newspaper she has set up two meetings with other districts over the past year, but didn't know how many she had organized since she began the consulting job in 1998.
She claims she received no fee for Spring Branch's business.
"There was no material benefit to me," she said.
Katz said she didn't feel obligated to inform the board of her work because her contract permits her to do paid consulting.
She expects the district will save $28 million over the next 10 years as a result of the contract with Energy Education. The district's deal calls for it to pay the company 25 to 35 percent of its savings, which means Energy Education could get between $7 and $9.8 million.
Bill Spears, founder and chief executive of Energy Education, said the company hires current and retired school superintendents as consultants because they offer access to other school leaders. The company claims it has contracted with more than 600 schools nationwide.
"The ... superintendent is basically an avenue to get our foot in the door and get an audience with the decision-maker," he said.
© 2016. All Rights Reserved. | Contact Us


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After navigating a big yellow school bus through an obstacle course that tested drivers' skills in mastering a diminishing clearance, backing, making a tight turn and parallel parking, Mitch Banner from Avery County Schools was named the best school bus driver in North Carolina at the annual State School Bus ROADeo held today in Raleigh.
The other top nine drivers in the competition in order of finish were Billy McKemey (Wake County Schools), Sharon Miller (Davie County Schools), Charles Mantie (Jones County Schools), Chris Owens (Sampson County Schools), Jeff Mellen (Wake County Schools), Boyce Chapman (Cabarrus County Schools), Alex Wright (Union County Schools), Lonnie Christenbury (Cabarrus County Schools) and Tracy Rayborn (Buncombe County Schools.)
Banner received a $500 cash prize and a trip to represent the state in the national school bus driving competition this summer in Milwaukee, Wis. The 2nd through 4th place finishers received $250, $150 and $100, respectively. Fifth through 10th place finishers won $50.
A total of 46 school bus drivers participated in the final testing and driving competition to name the top school bus driver in North Carolina. Each of the 46 contestants advanced to the state finals by placing in the top 10 of a regional competition. Most regional participants also advanced through a local ROADeo sponsored by their local school system.
In North Carolina, 785,000 public school students ride one of the state's 13,700 school buses every school day. School buses contribute to a statewide community savings of $245 million and 67 million gallons of fuel. The nation's school bus system eliminates the need for 17.3 million cars and 2.3 billion gallons of fuel annually. Additionally, according to the National Academy of Sciences, a child is over 13 times safer in a school bus than the average of other ways to get to and from school.
The North Carolina Pupil Transportation Association, the Division of Motor Vehicles, the North Carolina Department of Public Instruction's Transportation Services Section and Wake County Public School System's Transportation Department sponsor the annual State School Bus ROADeo.
About the North Carolina Department of Public Instruction:
The North Carolina Department of Public Instruction provides leadership to 115 local public school districts and 160 charter schools serving over 1.5 million students in kindergarten through high school graduation. The agency is responsible for all aspects of the state's public school system and works under the direction of the North Carolina State Board of Education.
For more information:
NCDPI Communication and Information Division, 919.807.3450.


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Evidence shows 'second messenger' (AMP) may have role in psoriasis
The first real clue to the pathophysiology of psoriasis may be emerging from studies being conducted in the Department of Dermatology at the University of Michigan Medical School, Ann Arbor.Dermatologist John J. Voorhees, MD, biochemist Elizabeth Duell, PhD, and dermatologists Lawrence J. Bass, MD, and John A. Powell, MD, reported to the Federation of American Societies for Experimental Biology meeting in Atlantic City that tissue from psoriatic lesions contains less 3′, 5′-adenosine monophosphate (cyclic AMP) than the uninvolved skin of a psoriasis patient or the skin of a normal person.The investigators biopsied the skin of 25 psoriasis patients and 25 normal volunteers. The two groups had been matched for sex. The differences between the cyclic AMP levels were statistically significant, and these findings also held when psoriatic and "normal" skin samples were compared on the basis of
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OxyNEO and other prescription drugs (like Opana, OxyContin, Vicodin, Xanax, etc) are extremely habit forming. The drugs can create a "heroin like" sense of euphoria and the user's brain chemistry can quickly alter to cause them to feel utterly dependent on the drug for a sense of well being.
If used long enough, physical addiction can accompany the mental addiction, and with each passing use, the recovery process becomes more difficult, longer, and more painful.
Potentially Deadly In Every Use
Do not wait another second to begin the process of seeking help if you or someone you care about is using narcotic medications. We have learned so very painfully what can happen if you "hope the problem goes away." That's not how addiction works – it typically progresses as a result of tolerance and increased dependence.
When is it Time to Worry?
Denial is part of the addiction phenomenon – and not just in the drug user. Entire families will often create elaborate rituals around ignoring the drug addiction and protecting the user from the consequences of their use.
We so often hear "I am not addicted and can stop at any time" but we've never heard "hmm, maybe intervening on this person and confronting them on their drug use and/or getting them professional help for substance addiction was not a good idea."
Simple benchmarks to use to know if there's a problem:
- the person continues seeking the drug after the prescription period should be over
- the person takes larger than prescribed dose
- the person sees more than one doctor ("doctor shopping")
- the person exaggerates symptoms and pain to get more medication ("drug seeking behavior")
There are many other symptoms and diagnostic tools that an addiction professional can help you with.
Getting Help with OxyNEO Drug Addiction
Here are some resource on getting help with OxyNEO addiction (or any type of drug/alcohol addiction):
Samhsa Substance Abuse Directory – A government website that is a very robust directory with a vast number of listings in every part of the United Dates.
National Institute on Drug Abuse – Another government website with a lot of information about drugs of abuse and how to get help.
Sober Living by the Sea Treatment Centers – An example of a good type of residential treatment center with a continuum of care that allows for long term addiction treatment with several levels to "step down" and gradually reintegrate back into a drug free life.


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We are now accepting papers for our September 2009 issue. The Utah Foreign Language Review (UFLR) has been a print journal for over a decade. However, we are now making the transition to being an online journal.
Please, send your papers (between 10 - 20 pgs. 12pt. font) to: firstname.lastname@example.com. The deadline is June 15th. You will be informed after this date if your paper has been accepted by our editorial board for publication.
The UFLR is sponsored by the Department of Languages and Literature - University of Utah.


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8 Reviews
It can kinda suck having a job, but at least you get to wear your KR3W K Slim Men's Chino Pant to work and still skate in it after. And as a bonus, you actually have the money to buy new decks when your old ones wear out so you're not getting splinters every time you grab your board.
- Stretch cotton chino is light and flexible for increased freedom of movement
- Slim fit has a narrow silhouette without being too tight
- Item #KRW1175
Tech Specs
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- Reviews
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Have questions about this product?
shit quality
- Familiarity: I've used it once or twice and have initial impressions
- Fit: True to size
They look great, but I've worn them twice, not even for skating, and they already have a hole in the side seam. Can't return them as I'm an employee and have worn them, so I'm just going to try to sew them back, but this is a horrible start for a pair of pants. Not expecting them to last long, and forget about trying to skate in them; they'll get destroyed in one session I'd imagine.
Clean, modern design
If you don't want a bunch of pockets blowin' up your style look no further.
Cool pants, but mine bleached
- Familiarity: I've used it several times
- Fit: True to size
- Size Bought: 34
These pants are exactly what I wanted-- slim fit, but a little stretchy so your bits don't get squished and you can jump around and all that. Only bad part is that I put them through the wash once, and now they have two little streaks of bleached fabric on them, even though I didn't use bleach. So, cool pants, but bummer they get so easily bleached.
solid work pant
- Familiarity: I've put it through the wringer
in addition to working at backcountry.com I moonlight as a bartender and server and have to wear black slacks. after destroying several pairs of cheap slacks from H&M I upgraded to these. great fit, good length, and durable. they wash well and haven't faded too much. Highly recommended for a nice casual pant.
Great pant but LOOOONG
- Familiarity: I've put it through the wringer
I'm 5'9 & 1/4 and these pants are easily 3 inches to long. I ordered Coffee and the Denim Charcoal in size 32 as they do not come in size 31. The Charcoal pant fits like a dream... minus the extra length. But the Coffee pant is bigger than the Charcoal pant! I should have ordered size 30 and they would have fit perfect with a little bit of wiggle room.
When sizing for the Coffee pant I would say size 32 = 33 x 35 1/2.
Sizing for the Charcoal pant would be about 32 = 32 x 35.
The length isn't a deal breaker, I just fold the bottoms.
Other than the sizing issue.... these pants are amazing and quickly worked their way up to be my favorite pants I own.
Lightweight, Stretchy, Amazing!
Pretty killer pants
- Familiarity: I've put it through the wringer
The fit is great, slim but not cupping your boys slim. They have a real light feel to them as well. Skateboarding in these is a dream, it feels like I'm not wearing any pants, these pants stretch in all the right places and never once have I felt constricted in them. I'd throw them through the wash before you wear them, they are a little stiff to start out, but a couple wears and you'll be loving these pants. The only reason I didn't give five stars, is because I'm around 6'2 and the inseam is not as long as I'd like it to be, but I don't care these pants rock and I'm happy with the purchase
The most comfy.
- Familiarity: I've put it through the wringer
Sometimes, you just don't want to wear denim. Denim can be a little restricting even with stretch in them. When those days come, I wear my Kslim chinos. They are so comfortable, sometimes I forget I am even wearing pants. Usually this would be a problem, but it really isn't because then I look down and see that I am in fact wearing pants, and they look good. I like that these are slim, but not TOO tight. They fit just right. Like Cinderlla's slipper only on my legs.
Fancy Pants
- Familiarity: I've put it through the wringer
Had to buy a pair of pants that were somewhat formal. Instead of buying a pair of slacks that i would only use at a funeral or a wedding i chose these. Classy enough for the fancy occasion, yet look casual with a t shirt and some sneakers.
When will you be stocking up on more of these / new colours???
I tightened them a little only through the knees and they became my best pants.


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Dec 12, 2007
Twelve days of chemo
Here is a lighter blog for the holiday season. You all know the tune. On the first day of chemo, my true love gave to me…a big dose of anti-nausea drugs. On the second day of chemo, my true love gave to me…extra hydration...
Suzette Lipscomb
Breast Cancer the Second Time
Making cancer less scary one breast at a time
Dec 5, 2007
Intuition: Your guide through treatment and diagnosis of breast cancer
If you are like me, you could count the number of times you wish you listened to your intuition and didn't. Let's see…the short list consists of when I went to get a lump checked in my breast, when I let the...
Nov 29, 2007
How to face breast cancer treatment alone
I had always thought I would get married someday, but the right guy never presented himself at the right time. So for the first time in my life, at 36 and facing the idea of possible death, no children and a year of chemo,...


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Atomic Cannon Mac
Atomic Cannon Mac Full Description
The ultimate artillery duel with 100 weapons of mass destruction!
Full Description
Isotope 244 Games
18, December 2008
5540 Kb
$19.95 -
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Product Info
The ultimate artillery duel with 100 weapons of mass destruction! Prepare for an action packed battle leading tanks to global domination. Atomic Cannon features 100 powerful weapons and 25 deformable scenic landscapes to wage war on. Additional features include death match and round based game modes, multiplayer mode with up to 16 players, real time smoke trails, weather effects, real physics, and five music tracks. Atomic Cannon features two types of game play including a point based round mode, and a death match mode where you fight to the end. Players take turns shooting at each other, and shot trajectories are calculated using real physics. There are also weather effects such as rain, snow, and dust storms that effect game play. You can blast your enemy with a vast array of weapons. Some weapons have radioactive effects that harm your opponents over time. Other weapons create landmasses you can use to your tactical advantage to hide behind as cover. Your arsenal is outfitted with numerous types of weapons including guns, bombs, missiles, rockets, and nukes. The landscape you battle on is randomly generated each round. There are six types of land formations including flat, hill, gulley, plateau, slope, and random. Each formation can be in one of the game's 25 diverse environments. Atomic Cannon supports scrollable landscapes, so your fight can be over a short distance or can span multiple screens. The battlefield is always altering because each shot changes the landscape's shape, creating vast craters or high mountains. The game allows up to eight human teams and eight computer teams battling at the same time, ensuring a customizable experience that can include your friends and family. Each team can have up to five tanks. The game features a dynamic set of music tracks to enhance the mood of your battle experience. Weapons have their own unique sound effects for firing and hitting their target.
What's new in current version
More than 85 weapons. Fully customizable weapon buying and economy system. Shields, armor, life, and many new weapon types. Improved the computers AI. All new tank graphics with 4 types of tanks. Bigger and better explosion effects. 200 other changes not listed.
5 MB of disk space.
Please contact Atomic Cannon Mac publisher,
Isotope 244 Games
if you have questions or issues regarding this product.
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Do you need dependable Internet speeds at a rate that won't break your budget? If so, you need CenturyLink® High-Speed Internet in Bouse, AZ. Get an Internet connection that's 100% your own—something many other Internet providers in Bouse simply can't offer. And the super-fast speeds of CenturyLink Internet let you turn your home into a wireless hub, seamlessly connecting all your web-enabled devices. CenturyLink Internet makes it easier, faster, and more enjoyable to watch movies, stream music, or even play games online. Plus, you can get 24/7 technical support—standard with every CenturyLink Internet package—and always-on wireless security through the Advanced Networking modem. You can also add CenturyLink @Ease for even more advanced security. Give us a call today to learn more about CenturyLink Internet in Bouse.
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This was my 4th cruise with Holland America, second on the beautiful Eurodam! We arrived in in Coopenhagen for the start of our cruise let me first say that our bags were lost no thanks to Delta and KLM! After a trying first day once we got on board the ship and talked to the front desk, Joyce put us at ease immediately saying that they would now take on the task of finding our luggage and not to worry they provided us with complimentary formal wear, for formal nights and also shaving kits so that we could make sure that we looked right for crusing around! Joyce you rock!
The cruise itself was beautiful Oslow, Scotland, Norway, Ireland the Shetland islands were just fantastic the tour guides were very knowledgeable and seemed genuinely interested in our questions and providing detailed answers!
The food and entertainment on the Eurodam was top notch just as it has been on all the Holland America ships that I have sailed on!
Diane Fast in the piano bar, is such a wonderful talent and very inviting! Going to the Piano Bar, is more like going into Diana's own home always welcoming, and if she did not know a song the night you asked she knew it either the next night or the following one!
The dining room was great as always, very very good food, and good proportions, the lido as with any kind of buffet was good but not great!
Overall loved this cruise met some wonderful people and look forward to sailing on another Holland ship in the near future!!


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The European Commission is carrying out a study to assess the impact of various options for ways to strengthen the rights in criminal proceedings of suspects or accused persons to be presumed innocent.
A linked objective, along with other measures included in the Roadmap for strengthening procedural rights of suspected or accused persons in criminal proceedings, is that Member States will have confidence that their citizens who find themselves involved in criminal proceedings in another Member State will be treated on the basis of common EU minimum standards, and consequently they will have greater trust in the criminal justice systems of other Member States.
The aim of this questionnaire is to obtain an understanding of the situation in all Member States and identify relevant domestic case law or jurisprudence relevant to the presumption of innocence. It also seeks to gather concrete examples of where issues arise in domestic law, in practice and in cross-border cases.
Finally, it is the opportunity for stakeholders to share their views on a possible EU measure on the presumption of innocence and the form it should take.
The questions refer to the situation in your country. If you have any questions on this study, please contact Quentin Liger (firstname.lastname@example.com).
To participate in the online study, please CLICK HERE. Closing date for completion is Friday, 29th March 2013.
If you would prefer to complete the survey in Word, you can download a version HERE.
CSES complies with the Data Protection Directive (95/46/EC), as implemented in the UK where we are based, under the Data Protection Act 1998. We also comply with EC Regulation No 45/2001 concerning the protection of individuals with regard to the processing of personal data by EU institutions.


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Oz Garcia's Top 5 Energy-Boosting Foods:
Pistachios are a great source of manganese, copper, and vitamin B6, all of which contribute to the production of energy in the cells. In addition, just one ounce of pistachios provides 3 grams of fiber, which slows digestion while providing a steady energy supply throughout the day. Enjoy these nuts as a snack on their own or sprinkled over yogurt, oatmeal, or a salad for a tasty crunch.
Not only is salmon high in protein and B vitamins, it is also a rich source of omega-3 fatty acids The anti-inflammatory property of this essential nutrient aids in providing the brain with a healthy supply of blood, which is important for memory and performance. Studies have shown that deficiencies in this nutrient may be linked to depression, a condition of which fatigue is a common symptom. Simply grill or bake salmon by brushing with olive oil and seasoning with salt, pepper, and lemon. If fresh fish is unavailable, mix a can of salmon with chopped onion, bell peppers, carrots, and celery. Add olive oil and balsamic vinegar, and enjoy over a bed of fresh greens.
Blueberries contain an impressive amount of antioxidants, nutrients that help protect our cells from free-radical damage. Vitamin C is one of these antioxidants, and just one cup of this delicious fruit provides about a quarter of our daily recommended need. There is some evidence that vitamin C may reduce levels of fatigue, so in combination with its supply of manganese and fiber, this sweet berry is a smart choice for a midday pick-me-up.
Probotic Rich Greek Yogurt
This creamy snack is both calcium- and protein-rich and a source of the amino acid tyrosine. In the body, tyrosine converts into the chemicals dopamine and adrenaline, the "feel-good" chemicals that help us to feel energized. The active cultures in yogurt not only work to maintain digestive health, but they also energize you by helping your immune system function efficiently. Choose Greek yogurt to avoid the excess sugar and carbohydrates in flavored varieties. Flavor it yourself with cinnamon, honey, or mid fresh berries. Combine yogurt with cucumber, sea salt, and chives for a great vegetable dip or a topping for baked sweet potatoes. If you just don't like the taste of yogurt, I recommend my clients take Culturelle for digestion and a stronger immune system.
One egg provides 6 grams of high-quality protein, which helps to satisfy hunger and provide a sustained source of energy. Eggs are also rich in the essential amino acid leucine, which aids in the regulation of blood sugar levels and energy production. Boiled eggs are a great snack to have on hand. They can be eaten on their own or mid with olive oil, lemon juice, and your favorite seasonings for a healthy egg salad.


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The Good News Is Unicorns Were Real. The Bad News Is They Were Hideous.
Like fuzzy rhinos.By Catie L'Heureux
Like fuzzy rhinos.By Catie L'Heureux
Or else.By Dayna Evans
The plan involves little science pouches.By Halle Kiefer
A new study found a correlation between watching Law and Order and decreased rape myth acceptance.By Jessica Roy
Hydrate before you fabricate.By Dayna Evans
Science!By Dee Lockett
A very educational discussion.By Maggie Lange
We had a lab test the latest illegal booze craze to hit New York City. The results may surprise you!By Katie Van Syckle
A new study compares all the trendy food regimens.By Maggie Lange
Beats wheatgrass shots!By Allison P. Davis
Scientists doing great work.By Maggie Lange
We can still eat them though, yes?By Allison P. Davis
According to number-crunchers.By Allison P. Davis
Why?By Dan Amira
We know. We've always known.By Allison P. Davis
Why we regret what we regret.By Allison P. Davis
They're not going to land!By Dan Amira
This has been another semi-regular reminder of your insignificance.By Dan Amira
Still no cure for cancer.By Dan Amira
Tell your dad to shove it.By Dan Amira


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University of Arkansas's Women's Basketball team loses 2011 senior class, so it's up to players like Calli Berna to lead.
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How much value do voters place on the services their tax dollars help provide?
That question is going to be answered in the coming months for the Bay County Library System, the Division on Aging and 911 Central Dispatch.
The countywide millages on which all three agencies heavily rely for revenue are set to expire this year.
Now is the time for all of them to start making a case for how frugal and responsible they've been with the resources at their disposal. Indeed, with the economy continuing its downward spiral, every tax-funded county service will — and should — come under scrutiny.
None of the three agencies whose millages sunset this year has said how much money they will seek or when they will seek it, but with so much of their funding for operations and programming at stake, they won't be able to continue their current levels without taxpayers' help.
We don't envy them the task ahead.
No matter how worthwhile the service to be provided, and all three of these agencies directly impact the quality of life for Bay County residents to one degree or another, whenever government has to ask taxpayers for money the outcome is never assured.
In this economy, with so many Bay County residents forced to cut back just to make ends meet, seeking continued support for services will be especially challenging, which is why the public agencies need to make their case early and often.
Voters have been supportive of millages for senior services and 911, consistently favoring renewals for the past 30 years, but now is not the time to rest on past good will. Doing so could spell disaster.
The current 0.7-mill tax for 911 generates almost $2 million, a sum that virtually funds the agency's entire operation. It's a safe bet to say that without the millage, the current central dispatch service would be greatly impacted, if not outright scrapped.
The Division on Aging's current 0.5-mill tax generates about $1.4 million.
The Bay County Library System, which currently brings in about $3 million from its 1-mill tax, perhaps has the hardest sales job ahead of it. Getting 1 mill was a struggle the last time.
Opponents of a controversial 2-mill tax for construction that passed after several attempts years earlier stirred up public sentiment against the renewal of the library's 1.2-mill operating tax. It went down to defeat twice in 2006.
Services were gutted as a result. Bay County had a new, state-of-the-art facility downtown, the Alice and Jack Wirt Public Library, and essentially no money to run it or the rest of the library system.
Library branch hours and staffing were slashed, programs eliminated. The Sage Branch Library, which has been called "the oldest continuously used library in Michigan," closed its doors for a year.
Voters, who wisely passed the current 1-mill tax in 2007, can consider the cuts a taste of what would come should the library system again find itself without an operating millage.
Indeed, taxpayer-funded services of every sort are already on the line.
For instance, in December, to offset losses in state and federal grant money, the Division of Aging announced it would be closing two of its senior dining centers and reducing to four the number of days it provides home-delivered meals, among other cuts.
Even if the millages are renewed, there's no guarantee other forces in the economy won't impact taxpayer-funded services and programs.
One mill brings in one buck for every $1,000 of a home's taxable value. When home values remain stagnant or slip, as they are now across Michigan, less tax is generated and adjustments in spending will have to be made.
So, county officials, start selling.
Before taxpayers decide the fate of millages, explain in detail what such agencies do, how the money is spent and why residents need it. Make a good enough case and this economy won't sound your death knell.