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FOLLY BEACH Alcohol on the beach became illegal overnight, but authorities enforcing the new law know that compliance might come more gradually.
Party buses let the good times roll
With flashy lights, cozy leather seats, built-in bars and a kickin sound system, Nick Millers Party Bus Charleston can host up to 30 people for a carousing cruise on Lowcountry roads.Millers mobile gathering spot is one of more than a half-dozen party buses to hit the roads around Charleston in recent years, offering plush rides for those want to celebrate in style.But the buses have drawn some unwelcome scrutiny in recent days following a Fourth of July gathering on Folly Beach that turned into a booze-fueled riot. Four buses showed up at the beach that day, disgorging dozens of drunken revelers and a disc jockey, authorities said.Just where those buses came from remains the subject of much speculation and rumor. They have been described as the bigger-style tour buses, and none of the local party-bus services contacted Wednesday had anything that large in their fleets.A number of party buses offer service to Folly. But two prominent companies contacted Wednesday said the Folly runs make up only a small part of their business, and their rigs would likely draw little notice from locals.We did some runs to Folly on the Fourth of July, but luckily they werent part of the problems that happened, said Miller, who also operates a 20-seat party bus. We dont bring massive amounts of people in and drop them off.Some residents blame an Atlanta-based event company called A.M.P. and a South Carolina-based clothing company called Good Ole Boys for organizing the Independence Day party, but A.M.P. has denied that is the case.The company posted a statement on its Facebook page Monday stating that independent suppliers of party buses have confirmed that all of the buses were rented by different individuals at different times and with different pickup locations.This is a custom that has gone on for several years, since the traffic is heavy to Folly and riding a bus is the best safe way to get to the beach especially for those that are drinking, the statement read.Reaction to the buses has been mixed on Folly. Some worry about the potential for busing in large groups of drunken visitors. Others see some promise in companies offering shuttle options that keep drunken drivers off the road and reduce car traffic.Looks like about twenty five less cars to park on our yards to me! one resident wrote on the Follitics Facebook page for islanders.Party buses have become big business in larger cities around the country. In Charleston the trend has been a bit slower to catch on, but bus services say they are busy on weekends.Most allow riders to drink while on board, but they must bring their own alcohol. Depending on size and amenities, the buses can command rates of upwards of $150 an hour.Tracey Pendleton is sales manager for Tri County Transport, which operates The Monster Party Bus and two similar rigs. Pendleton said her companys party buses mainly transport wedding parties, prom-goers, birthday attendees and the like.Most trips to Folly are to pick up large families in town for vacation, she said.Our guests are mature adults and dont have any issues, she said. We just try to make it easier for them to get where theyre going and have fun.
Wednesday marked the first day of a 60-day booze ban on Folly Beach and an end to the islands run as the only local beach that allowed drinking on the sand.
Karla Mueller and Jana Crawford, sisters visiting from Ohio, learned about the emergency ordinance Wednesday afternoon from their bartender at the The Tides tiki bar.
We thought this would be a great vacation destination, because its the only place where you can drink on the beach, Mueller said. The pair chose Folly instead of Charleston for that very reason.
Now, taking a drink out on the sand could cost as much as $1,092 in fines.
The emergency ordinance came after residents packed City Hall Tuesday, demanding that their elected officials help keep their island cleaner and safer.
For years, Folly Beach has battled against weekend warriors urinating and vomiting in yards, leaving trash behind and disturbing residents routines.
The problem culminated on the Fourth of July with a gathering that law enforcement officers later described as a riot. The event left in its wake more than 100 bags of garbage, a handful of injured public safety officers and a stack of arrest reports.
Days earlier, the Folly newsletter The Sandspur printed a message warning residents about people who doctor drinks with date-rape drugs, sell crack cocaine and hallucinogenic bath salts and systematically break into homes.
Residents rallied for an alcohol ban to keep out people who come to their hometown for the sole purpose of getting wasted.
Public Safety Chief Dennis Brown said city officials ordered 61 signs announcing the alcohol ban at beach access points and illuminated signs on the causeway leading onto Folly.
He plans to station public safety officers at key entry points to remind people with coolers about the new law.
Were not going to search coolers, Brown said. We cant do that legally.
But if an officer spots someone with alcohol on the beach, he can impose a fine ranging from $250 to $1,092. The price comes at the officers discretion and will be based largely on the offenders attitude.
One of the first steps is going to be education, Brown said. You cant correct years of behavior overnight.
Follys Public Safety Department comprises 16 full-time officers, a limited staff to deal with an estimated 60,000 people who pack the beach on busy summer weekends.
Asked if the new law will pull those officers away from more pressing problems, Brown said his department will prioritize its calls and respond to each of them accordingly.
Folly Beach City Council meets again tonight to discuss adding a referendum to the November general-election ballot that would let residents decide whether to make the alcohol ban permanent. What happens between the end of the 60-day emergency ordinance and Election Day remains unclear.
Mayor Tim Goodwin said city officials will consider a possible extension of the ban in those interim months.
We just need to look at where we are at that point, he said. Until then, authorities are scrambling to get the word out fast, Goodwin said, with signs, calls to real estate agents and a strong public safety presence.
Were not going to have alcohol-sniffing dogs on the beach, Goodwin said. (Officers are) not going to wander up to your cooler unless they have probable cause ... but theyre not going to hand out cups anymore.
Until Tuesdays City Council vote, residents and visitors could bring alcohol to the beach as long as they kept their drinks in a plastic cup.
The Charleston RiverDogs baseball team capitalized on the news with an announcement Wednesday that tonights game would include a beer station near its sandy area called Shoeless Joes Hill.
If you want to enjoy an ice cold beer with some sand between your toes, then Joseph P. Riley Jr. Park is now the only legal place in the Lowcountry you can do so, the statement said.
Some beachgoers wondered if other islands would ramp up patrols this weekend after Follys ban. Isle of Palms Police Chief Tom Buckhannon said his department plans for business as usual moving forward.
Nothing is going to change because of Folly, Buckhannon said. When it comes to sneaking alcohol onto the beach, he added, people always try to do that.
Reach Allyson Bird at 937-5594.
Photographs by Grace Beahm/staff Folly Beach has ordered 61 signs announcing the alcohol ban, to be placed at beach-access points. There also will be illuminated signs on the causeway leading to town.×


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It's bad enough when a stock loses 10 percent of its value over one quarter. It's even worse when the same stock loses twice that amount in one day.
As I wrote Sunday, DFC Global Corp. was the worst in terms of performance among the Philly 50 local stocks so far in 2013.
The 10.2 percent drop in the price of DFC's common stock between Dec. 31 and March 28 came during a quarter when the Standard & Poor's 500 index rose a robust 10 percent.

subset: commoncrawl


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Handraisers are the people who are significantly more active in your emails than usual, or in comparison to the rest of your contacts. And today we're going to show you how to identify and interact with them.
Want a sneak peak of how eMerge works for you and your audience? Let us give you a 5-day interactive experience guaranteed to engage.
*Please fill out all fields accurately so that you can truly experience eMerge.


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Do all 3 year olds have a compulsive lying to your face problem?
My 3yo will lie ....if I ask him questions. He very obviously pee'd in his pants the other night, but told me he didn't. Or if he dumps all of his toys out on the basement floor...obviously I can see that he did it. Asking a toddler questions is pointless.
He also likes to wear his Batman pajamas and tell me "Batman doesn't lay down!, Batman doesn't eat!" etc. I've found after having my own children, that what I once thought was unusual w/my SD is fairly normal.
kaleb alan [6] - kameron christopher [5] - karlie ^3.12^ - rainbow karson james [3] - Kylie Marie!! [1.9.15] and Keri Rose born 1.24.16!!
Dss now knows what lying is, however cannot fully understand when someone is just joking, sarcasm, or exaggeration. Dss called me a liar earlier cuz i was telling SO how tired i was after climbing "that mountain" of which was the stairs i was referring to.
It comes with the territory of young children. I saw this quote on another board from a Kimdergarten teacher. This is what she says to parents at orientation "If you only believe half of what your child tells you about what happens at Kindergarten, I'll only believe half of what your child tells me about what happens in your home."
Children are full of elaborate stories, mistruths and fictions. I was a nanny to a 3 year old girl who told me her mother beats raccoons to death and drains their blood for cookies. She was a HUGE liar. She told me she was married to the Prince of England, he just didn't know it yet. We used to joke she was going to be a stalker when she grew up. She said her 3 month old twin siblings came in her room at night and took her books. As she approached 4, we really started to emphasize truth vs fiction and the importance of telling people the truth. She learned, but she always had a vivid sense of imagination. She also had a host of imaginary friends and would tell the most outrageous stories about her imaginary friends.
It's not a SK issue, just a young child issue. Let her know when you know the truth (blaming someone else for her actions, etc) and if it's just a random story or other words of fiction, nod along and say "Oh wow."
My journey to adoption...


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Cedarville University
Plumsteadville NACCAP
October 30, 2012 from 10:30 a.m.–12:30 p.m.
Choosing a college is a major decision. Choosing a Christ-centered college is a wise selection!
Come and talk with me, Emma Kollie, your area admissions counselor to learn how you will be challenged academically and spiritually at Cedarville University.
I look forward to meeting you!
5765 Old Easton Rd
Plumsteadville, PA 18949 View Map
CU Representatives
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Miss Emma Kollie
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Presentation, Admissions


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- DEERFIELD -The Deerfield Historical Society's meeting is slated from 7 to 8 p.m. Jan. 28 at the Deerfield Town Hall, 1450 state Route 14. The public is welcome.
- SALEM - The Salem High School Class of 1955 is invited to lunch at 11:30 a.m. Jan. 29 at Adele's Place.
- SALEM - The Salem High School Class of 1973 plans to meet for breakfast at 10 a.m. Feb. 1 at the Skyline Diner.
- COLUMBIANA - Classmates of the Fairfield/Waterford High School Class of 1959 are invited to dinner at 5:30 p.m. Feb. 3 at Cafe 422 in Boardman.
- SALEM - Twelve members of Weingart Cousins met recently. The group's next breakfast meeting begins at 9 a.m. Feb. 11.
- SALEM - Goshen Home Extension will meet for lunch at 11 a.m. Feb. 14 at the Salem Hills Golf and Country Club.
- SEBRING - The Sebring High School group "To infinity and beyond" is sponsoring a family board game night from 6:30 to 8:30 p.m. Jan. 29 at Sebring High School. Admission is $2 per person. Admission price also includes pizza and a beverage. Popcorn will be available for sale. All proceeds will fund the group's trip to London and Paris.
- SALEM - The Seven and One Club met Jan. 15 at the home of Mrs. John Hively in New Waterford. Her guests included Mrs. Keith Keslar and Mrs. Roger Cooley. Cards were played after the luncheon with prizes being won by the following: Mrs. Larry Dearth, first place; Mrs. Gerald Mincks, second place; Mrs. Jack Bruderly, travel. Mrs. Hively served an apple cake topped with whipped cream for dessert. The next club night begins at 7 p.m. Feb. 19 at the Dearth home.
- CANFIELD - Divorce/Death Aren't Really the End meets at 7:30 p.m. every Thursday at the Disciples Christian Church, 565 Boardman-Canfield Road. Upcoming events include:
Feb. 1: Bowling at Boardman Lanes, 7 p.m.
Feb. 4, 11, 18, 25: Dance classes, Judy Conti's, Austintown, 7 p.m.
Feb. 7, 14: Movies 8, lobby, Shops of Boardman Park, 6:30 p.m.
Feb. 12: Volunteer at Second Harvest Food Bank, 5-7 p.m.
Feb. 17: Meet-up at Mocha House, Boardman, 7 p.m.
Feb. 19: Practice bowling night at Wedgewood Lanes, 7 p.m.
Feb. 22: Bowling extravaganza at Boardman Lanes, 7 p.m.
Feb. 28: Card night at Denny's, Boardman, 6-10 p.m.
For more information call 330-793-5856, 330-533-7062 or 330-793-1484.
- NORTH GEORGETOWN - Sid French of Cuyahoga Falls was elected president during election of officers held recently for the Columbiana County Antique Tractor Association. Other new officers include John Cochran of Tallmadge, vice president; John Harris of North Georgetown, treasurer; and Reva Montgomery of Lordstown, secretary. The club thanked outgoing officers, Dennis Flugan and Jim Elder, for all their hard work these past years.
The club is planning the 2014 pulling season. The new season starts in April and ends in September with at least two jackpot pulls this year with the option for more. Monthly meetings begin at 7 p.m. the first Thursday of each month at the North Georgetown Fire Hall. Anyone interested in antique tractor pulls is welcome to attend. For more information call 330-310-5413 or 330-814-7245.
- SALEM - The Salem High School Class of 1974 is holding its 40th-year reunion this summer and is seeking addresses for classmates.
The information may be forwarded to the SHS Alumni Office at 330-332-1427. The classmates include: Beth Kleinman McDevitt, Bob Krebs, Cathy Booth Brown, Cheryl Denkhaus, Chester Fortune, Cliff Protzman, David Callahan, David Crookston, David Gushert, David Mrugala, David Ray, Debbie Hardwick Cross, Debbie Rummel, Donna Markovich, Doreen Singer Chamberlain, Earl May III, James Votaw, John Coler, John Hughes, Judy Cowie Schneider, Kathleen Leipper Kosch, Kay Adams Lake, Kurt VanFossan, Leeanne Curtis, Mark Janosik, Mark Landwert, Mark Stilwell, Martin Field, Mary Cernuto Constantino, Mary Wright Kelley, Maryanne Snyder Cline, Maurice Smith, Michael Colian, Mike Crouse, Mike Jordan, Mike McBride, Mike McGowan, Mike Miner, Pam Brennan Steens, Patricia Snyder, Patti Preisler Powell, Randy Hrvatin, Randy Roberts, Rose Rance, Roxi Endres, Sam Barth, Steve Adams, Steve Waugh, Sue Horning Hughs, Susan Byrd, Susan Menough Flatinger, Terry Mountz, Thomas Krepps, Timothy Eaton and Timothy Maloy.
- SALEM - Renowned international speaker Pam Stenzel will be speak at 7 p.m. Feb. 1 at the Salem First Friends Church, 1028 Jennings Ave.
Stenzel tackles the tough issues of sex with candor, insight, humor, and the challenge for young people to get the abstinence advantage. This community wide event contains material suitable for seventh graders and older. Refreshments follow the presentation.
- SALEM - New Horizon grief support sessions are available to all adults who are grieving the loss of a loved one through death. Sessions begin from 3 to 4:30 p.m. Feb. 5 and will run for eight weeks in the Emmanuel Lutheran Church Education Building at 251 S. Broadway Ave. The facilitator will be Kim Calhoun of Hospice of the Valley. For more information, or to register for this group, call the church office at 330-332-5042.
- CANFIELD - Calla Community Church's missionary society is sponsoring a soup sale from 4 p.m. Feb. 7, until sold out, at 6482 W. Calla Road. Potato soup and chicken with homemade noodles are available at $6 per quart. Also featured will be fresh baked bread at $2 per loaf. Proceeds benefit local mission projects. To pre-order call 330-507-2255 or 330-501-1597.
- SALEM - The staff at the Family Practice Center of Salem is sponsoring and volunteering their time to host the Banquet in Salem in appreciation for the kindness and generosity the physicians at the Family Practice Center have shown throughout the year, including Dr. Richard Fawcett, Dr. Richard Banning, Dr. James Gardner, Dr. Dean Economous and Dr. Michael Sevilla.
The meal will be served from 5 to 7 p.m. Monday at the Memorial Building, 785 E. State St. Chicken noodle soup, pork loin, mashed potatoes and gravy, green beans, applesauce, rolls, fresh vegetables and fruit and ice cream sundaes will be served.
Additional sponsors are needed. For more information call Patty Colian at 330-831-2169.
- SALEM - Lion and Lamb Christian Resources in Salem and Niles will host Vacation Bible School (VBS) workshops from 6 to 8 p.m. Feb. 7 at Grace Fellowship Church, 2150 Niles Cortland Road SE, Warren, 330-505-1319; and 10 a.m. to noon Feb. 8 at Lion and Lamb, 145 S. Broadway Ave., 330-332-8501.
Presentations will run two hours, with time afterward to talk with the workshop presenters and view VBS materials. VBS starter kits are in store and available now to review.
- SALEM - Church Women United will cancel its 1 p.m. meeting on Monday, if, there is a snow parking ban or no school.
- HANOVERTON - A spaghetti dinner will be served 4 to 7 p.m. Jan. 31, before the basketball homecoming game, at United Local High School cafeteria.
Cost is $5 for adults, $4 for students, and free for under 5. Carryouts are available. The public is welcome. Proceeds will be used for the eighth-grade trip to Washington, D.C.
- BELOIT - West Branch is hosting a charity auction fundraiser to benefit athletics at 3 p.m. Feb. 15 in the high school auditorium.
Anyone wishing to donate or advertise is asked to email firstname.lastname@example.com (subject heading: auction) or call 330-938-4455. There are already several desirable items including a guided pheasant hunting trip and tour offered by Sunrise Farms, group passes to SkyMax, senior picture packages by Street Style Photography, Harley-Davidson articles by Thunder HD, Cleveland Browns and Cavs autographed memorabilia, Pittsburgh Steelers and Mount Union gear, Mountaineer Casino overnight golf and gaming get-aways, spa packages, gift cards, gift baskets, electronics, etc.
Admission is free and all forms of payment, including credit cards, will be accepted. The event is organized by the reigning Northeastern Buckeye Conference Champion West Branch Girls' Track Team. The auction will be conducted by Kiko Auctions.
- SALEM - Salem Public Library's Wellness Wednesday series continues from 6:30 to 7:30 p.m. Feb. 12 with a program by Hospice of the Valley.
Presenter Rosemary Antonucci will discuss what Hospice does, why volunteers are an integral part of the team, how volunteers can support caregivers. Antonucci will also focus on the necessity of wellness for caregivers. There is no cost to attend the program in the library's Quaker Room at 821 E. State St. Registration is encouraged at www.salem.lib.oh.us or 330-332-0042.
- LISBON - Columbiana County Auditor Nancy Milliken reminds all dog owners who harbor dogs 3 months of age or older that they must license their dogs annually. The deadline for purchasing 2014 dog licenses is Jan. 31.
Licenses can be purchased in the auditor's office at 105 S. Market St. or at Ace Hardware in Columbiana and Middleton; Damascus General Store in Damascus; Adrian's Restaurant and Carol's Corner in East Liverpool; Fuller's Hardware in East Palestine; Yard Bark in Salem; and Center Pharmacy in Wellsville.
Cost is $10 per dog or $50 for a kennel license. Kennel licenses can only be purchased at the county dog warden's office at 8455 County Home Road, Lisbon.
If you fail to meet the registration deadline you will be subject to a penalty that is equal to the cost of the license or kennel license. After Jan. 31, licenses can only be purchased at the auditor's office.


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International Center For Environmental Arts
Rating: 5 stars 1 1 review 99
519 Karen Dr Berea OH 44017 USA
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"David Jakupca and his International Center for Environmental Arts (ICEA) is a team of art experts who have successfully fused not-for-profit idealism with for-profit pragmatism. The result is the country's only comprehensive professional artist run cultural program exclusively devoted to environmental and humanitarian concerns facing mankind in the 21st century. Spending his time devising strategies that have allowed art and culture to influence people worldwide in promoting the iceality of a better way of living, the 'better way' is by successfully demonstrating that a socially aware artists with a vision can make a real difference at the global level. Ed Burns, President Cleveland Jaycees
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The best free personal finance software programs online
Apr 2, 2013, 11:51 a.m.
When you want free online personal finance software, you'll find many options on the Internet. While it's difficult to identify the best options, the suggestions noted herein are favored by many people, both young and more mature. Remember, "best" is a relative term, meaning different things to different people. What others may consider the "best" free online personal finance software, may not be the "best" for you. Here are some consistently top options.
This highly-regarded online personal finance software, considered to be the best by many observers, permits you to register all of your bank and savings accounts, credit cards and investment accounts in one place. You can securely track and monitor all of your transactions. Filled with lots of financial applications and tools, this software allows you to generate weekly spending reports, email alerts, create personal budgets and set financial goals. Mint also helps you save money, notifying you of spending irregularities, hidden, late and overdraft fees, and credit card rate changes.
Organizing your financial accounts in one location is a vital GreenSherpa feature. You'll also be able to combine this free online personal finance software with the website's personal money management features. Valuable features permit you to record current--and project future--cash flow, synchronize transactions in your accounts, create budgets, track spending, and, even, collaborate with your CPA or financial planner to improve your finances. You can customize your dashboard to deliver the information you want.
Buxfer allows you to download and import transactions from other software, whether they are in Quicken, Excel or MS Money file formats. This feature permits you to move from other online personal financial software to Buxfer without losing time, patience or transactions. With mobile applications for iPhone, Blackberry and Windows Mobile powered smartphones, you can take Buxfer with you.
This software also acts as your personal financial assistant. MoneyStrands gives you the ability to import synchronized accounts, including credit cards, bank accounts, and personal or business loans online into one personal finance location. With synchronization comes the ability to keep your balances and spending data up-to-date, while identifying potential cash flow issues. Creating budgets, tracking spending, receiving alerts and designing spreadsheets is easy, fast and accurate.
If you find one of these you like, use it. Should you still wish to search, other popular sites are Rudder, Thrive, Mvelopes and HelloWallet . Finding the best online personal financial software for you will take a little time, but save you lots of time and money in the future.
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SALEM - Kenneth W. Hogue Sr., 68, of Salem, died at 3:55 p.m. Saturday at Salem Regional Medical Center.
He was born on March 20, 1946 in Salem, Ohio, the son of the late John and Ruth (Snow) Hogue.
He had been employed at Kaiser / National Refractory for 29 years, and was a 1964 graduate of Leetonia High School.
He is survived by his wife, the former Mary F. Grimm, whom he married on Jan. 27, 1979, their children, Kenneth Hogue Jr., New Philadelphia, Ohio, Tammy McGhee of Salem, Jason (Sarah) Hogue of Arizona, Meda Hirst of Salem, Carol (James) Meyer of Brighton, Col., and Lori (David) Darby of Ludowici, Ga.; siblings, Jack (Brenda) Hogue of Boston, Mass., and Rebecca (Daryl) Maenz of Lisbon.
A Celebration of Life Services will be observed at 7 p.m. Wednesday at the Arbaugh-Pearce-Greenisen & Sons Funeral and Cremation Services, Salem. The Rev. Charles F. Hamilton of the Upper Room in Columbiana will officiate. The burial will be private for the family. A time of visitation will be held one hour prior to the services.
The family is asking for donation of new handmade full size quilts, tie or fleece blankets. The Salem Regional Medical Center is collecting new blankets for their hospice cart. Please bring one to be donated in Mr. Hogue's memory. You may also make a donation to Hospice of the Valley.
Please go to the web site and read the complete obituary, sign the guestbook or leave a tribute at www.apgreenisenfh.com
Arrangements were by Affordable Cremations (1-855-CREMATE) / Arbaugh-Pearce-Greenisen & Sons Funeral and Cremation Services, Salem.


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1988 Richard Dent Chicago Bears Open Starting Lineup SLU NFL Football W / Helmet
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Toys, Dolls, Games & Puzzles
- Source: eBay
- Sold Date: Feb 19, 2012
- Channel: Auction House
Also, a little about shipping and packaging. I do combined shipping and you can save with each purchase, please see shipping rules. To securely and safely ship; this figure will be wrapped in bubble wrap and placed in a brown durable 6"X9" envelope. I will ship as quickly as I can, please see my feedback.
Below are some fascinating details about the history of Starting Lineup:
Starting Lineup was a brand of action figures produced from 1988 to 2001, first by Kenner and later by Hasbro . They were conceived by Pat McInally , himself a former professional American football player with the Cincinnati Bengals , in 1986 . The figures became very popular, and eventually included sports stars from baseball, football, basketball, and hockey; and, to a lesser extent, auto racing, boxing, track & field, skating, soccer, and golf.McInally came up with the idea during a visit to a toy store. He noticed there were many figurines available ... read more


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If you like to dine with chefs who eat their own cooking, filings this afternoon show that Charles I. Clough Jr. has bought fresh shares of the closed-end Clough Global Opportunities Fund (GLO).
More than half of Clough Capital Partners' $3.8 billion in assets under management is held in the firm's three closed-end funds. The chairman and CEO picked up 12,000 shares at an average price of $11.63 over the last few sessions, according to today's SEC form 4. That follows a purchase of 8,900 shares last week at $11.66.
This fund has a 9.4% distribution and trades at a 13% discount, according to CEFConnect. As of Aug. 31, the fund was 74% investing in stocks, mostly in the U.S., and 16% in fixed income, the lion's share of which is government debt. Top equity holdings at that disclosure were Apple (AAPL), Bank of America (BAC) and Google (GOOG).
As exchange-traded funds and other investing vehicles have ballooned in number, the task of figuring out what works well and what doesn't has only gotten harder. Barrons.com's Focus on Funds looks under the hood of ETFs, mutual funds and hedge funds for overlooked values, actionable ideas and the latest pitfalls for fund investors.
Chris Dieterich has covered the U.S. stock market for The Wall Street Journal and Dow Jones Newswires. He is a graduate of Regis University and the Missouri School of Journalism.
Write to Chris at email@example.com


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Dirty Sluty Mom Shows Daughter How To Fuck Hard Cock
Check out these pictures from our latest Mother Daughter Fuck adventure. Our "male talent" was no where to be found for our video today, so when Clark, the grocery delivery guy stopped by to make his delivery, we decided he would be perfect for today's video. I'll admit that I've always wanted a special delivery from him. I had him put the groceries in the kitchen then told him I needed him to come upstairs for a second. He didn't even ask why.
When he saw all of the cameras pointed at the bed, he asked what we were doing. That's when my daughter and I told him about the site. He was shocked, but more than willing to join in for our next video. It wasn't long before all three of us were on the bed. We were ripping off his clothes to get to his hard cock. We took turns sucking on him, making sure he was rock hard. Then, we both got drilled by him. Then finally, we got his special delivery – loads of hot sperm all over our breasts.


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Hi looking for some specific information on 18 seaters like HAL/Dornier 228, Jetstream 31 and B1900D. I want to compare these aircraft for missions ranging from 1 to 1.5 hours:
Passenger Capacity apart from 2 cockpit crew and 1 cabin crew, Pressurisation, Range in KM, Cruising speed, Takeoff distance to 50 ft, Fuel Flow/Hour, Operating (Fuel) cost per km, Baggage capacity (front and rear max), Night Flying Ability, Single Cockpit Crew?, Typical Annual Least Cost (A-M-I/A-C-M-I).
Also can the Dornier 228/J32 be configured with a full/mini-galley capable of serving small hot meals and accomodate upto 1 cabin crew? I have seen a pic of a Dornier 228 cabin with "TOILET" labelled across the rear bulkhead wall. Does this mean that fitting a toilet will take away baggage capacity on the D228? The Dornier I have seen did not have a toilet.
Also frm what I have seen, the last(bulkhead) row of the Dornier with 3 seats can be used for 1 crew seat in the center (folded away when using galley), the right window seat being replaced by a galley while the left window seat left open for a toilet door. Would this work? But this would reduce capacity from 19 to 16.
How would this work on a J32? and a B1900D? Toilet and galley comes as std fitting on these aircraft?
The B1900D is pressurised I think. What about the other 2? How would the
D228 perform at airports at altitudes like 18000 feet (leh?). Ths Indian Airforce does operate the Dornier at these altitudes but can it be operated in civilian transport mode if unpressurised?
Any help would be appreciated.
Thanks and regards. Rainer


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I have been doing extensive research on thyroid function as a result of diet. Primal, specifically using animal proteins, helps to boost thyroid function. I wanted to know if anyone has scientific proof or personal experience with being hypothyroid and boosting it through diet. I will have to take meds, since mine is very very low, but it seems that I can take such a high dose and it doesnt seem to increase my t3/t4 very much.
Thanks for any input.


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Web site is up! With a unique m3k pen to showcase..
Well it has been a long time since you have heard any news from me. I have been taking a much needed break, and am starting to get back into... Read more
5 pen case are machined
I have some good news for those who requested the 5 pen set . I finished the machining of the 5 pen cases. Here is picture and I included a... Read more
Anodizing cases, pens and 2 pen liner complete
While I have anodized almost all of the bead blasted black cases, I had several items to catch up on. 1. I had many caps that were defective and had... Read more
Orange not orange enough?
This update is about those who were recently shipped a pen with orange in it.
One backer pointed out to me that it looks more gold than orange. I did... Read more
Pens without cases almost all shipped
For those of you who had requested a pen without a case you will either have a tracking number by now, will get one tonight, or will get an email... Read more
Pens progress
In this update, I will start with pens update first then the cases.
Status for pens without a case:
clear - I still have one that I have not shipped.... Read more
Case machining close to completion.
I apologize for being so late on this update. I have been making progress. As of tonight, I have 50 cases that the machining is complete see link (only 49... Read more
Still machining cases and anodizing!
The attached pictures shows the stack of cases has increased. Not fast enough, but I can say that the main machining operation on the body of all the cases is... Read more
Case machining finally becoming routine!
So this update contains good news and not so good news. The good news is that case machining has begun to stabilize such that I can leave the machine to... Read more
New Case Tooling in action!
I completed this tooling to help me machine 8 cases at a time. I finished the machining the tool late last week, but wanted to get some testing in... Read more
New case tooling
Unfortunately, circumstances have kept me out of the shop longer than I had hoped. But despite that I expect to complete the new case tooling in the next 2 days.... Read more
Blue anodize
This will be a short update, but wanted to get something out to everybody. Last week the anodizer did a great job on all the blue pen pieces. And as... Read more
Back in the shop: 5 Pen Case Design! 2 pen liner design!
While on business travel last week, i was able to accomplish a few things that don't involve me being in the shop. One of the biggest for me is that... Read more
Outsourcing some anodization to speed progress
As you can infer from the title, I am not able to anodize pens at the rate that I would like to get them all delivered quickly. And on top... Read more
Tip: replacing the refill!
Hi Backers,
I have received several questions on how to replace the refill. One of the things that I changed from the original prototype was how to take the pen... Read more
First production bead blasted case!
Since I was having issues with the polished case, I went ahead and started the first bead blasted cases. I thought some of you might be interested in seeing it.... Read more
Case Finishing
Time for another update.
I have to report another delay for the cases, I thought that I had bridged the last hurdle with cases when I got the process... Read more
Woo Hoo Liners!!!!! Please read for another available option!
I am happy to announce that the liner moulds are working beautifully. I am using a soft high quality platinum cure silicon rubber. It has a great feel and looks... Read more
Mid January update
If some of you have followed my comments in the comments area, you will see that I started tackling the anodization issues. I was struggling with a pretty high rejection... Read more
New Years Eve Update!
Year end seems like a good time to give an update. For some of you backers, it is already 2013. But I have another 2+ hours to go here.
So... Read more
Getting back in the shop..
It is probably the longest gap between updates that I have done. I apologize for that but since I was not in the shop for a week and a half,... Read more
One more delay
It has been too long since the last update.
All back bodies are machined. 200 of the front bodies have been machined. ( i had to scrap 90 while working... Read more
Spring machining & spacers
More than time for an update...
Front bodies were delayed for last set up. I expect to finish them all by tomorrow. In the mean time,I have also been working... Read more
Pen Back Bodies have all been machined!
Late last night, I finished all the pen body backs for everyone's pen(s). Shown in the picture at the bottom of the page are 270 of them and another 55... Read more
Backs of pens are near completion
Past time for me to post an update.
For those of you who have recently read the comment section, I had an issue with my mill losing z position. After... Read more
Anodization line bottle neck
Sorry for the delayed update.
I have 8 more pens ready to ship tomorrow morning. Unfortunately the pictures here don't look as good as in real life. But you get... Read more
Shipments begin
The first 4 pens (bead blasted) to ship:
Hi res picture:
As I finish them, I will on occasion take some pictures of some of the more unique... Read more
Almost there
Well it has been rough weekend, my goal was to have shipped some pens already. While machining the plain sleeves last week, I accidentally jogged my slitting saw into a... Read more
Brushed finish finalized
I have a brushed finish that I am happy with now. Also I am on target for finishing the first pens today.
You can see the hi res pic of... Read more
Brushed finish update
I have what I feel is better brushed finish, but I want to anodize it first before I post pictures. Unfortunately I will not be able to work on the... Read more
And another quick post!
For those of you who have been waiting to turn in your survey, I can give you until Sunday the 23rd to decide. Since I have enough respondents to keep... Read more
Another quick update!
Although some of you are happy with the brushed look from the not so detailed pictures, I am not happy with it. So I will be trying for a little... Read more
Some finishes to look at!
I got the bead blasted and brushed finish examples anodized tonight. They are hanging to dry at the moment. Below you can see the red and black bead blasted examples.... Read more
Back body machining is complete for first batch!
After completing the fixture for machining the flip side of the backbody, the machining did not take long. Pictures below:
I did start the spring testing. The fixture was not... Read more
New fixture working great!
Time for an update. In the last update I was working on the tool that would clamp the individual workpieces independently. I am happy to report that it is working... Read more
Deburring success, Backbody machining fixture, first batch of refills..
The past week has brought many successes and only one major schedule hurdle.
The good news first:
As you can see in the video, the first back-body fixture is near... Read more
Machining of first set of front bodies complete
In my last update, I had started the machining of the front bodies. I am happy to say that is complete. Unfortunately not all 50 made it without damage. 2... Read more
Production has begun! First chips are flying!
So it was a long weekend! But I got the tooling completed and began cutting the front body of the pen. I had a bit more work to get the... Read more
Surveys have now all been sent out!
I just sent out the last of the surveys...
As I stated in some of the surveys. If you would like to wait to respond after you get a look... Read more
Planning, tools, and material acquisition
Time for an update! It has been just over a week since the project was funded. From here on out, I hope to provide weekly updates. I have spent this... Read more
$250 reward level update (last day deal!)
Since I am starting to get some interest in the $250 level reward. I will be including the machined spring option for free at that level. And you will be... Read more
Uniball 207 refill support
With 13 hours to go, I am happy to announce that I will be supporting the uniball 207 refill. But there are limitations. Since the uniball refill is larger in... Read more
Lower Canadian and Mexican Shipping rate
When I decided to set what the extra amount that would be needed for international shipment, I based my decision on the international small box flat shipping rate with the... Read more
Status with less than 2 days to go
First I want to attach a picture of a prototype liner for the case. It seems to me that a velvet liner with foam backing is the way to go... Read more
Color pens with threads cut & Serial number pens update
Check out the assembled color pen pics. And I also threw in a video that shows how I create the threads on a cnc milling machine.
Serial Numbered Pen... Read more
Some colors drying after anodize!
Just to give everyone a better idea of what the colors will look like. I have few prototype pieces that are drying. I will have to get some much better... Read more
Raising the Limit on $135 level reward!
I was amazed at the popularity of the $135 level reward. I had many backers who had wanted it but it sold out way too fast. So I looked at... Read more
Thank You!!!!!
You backers are great!!!!! In one day, we have received more pledges than ever before!!! Thank you all for helping me get to my goal! My job now is to... Read more
New limited reward level. Other status
I have added a new reward level that includes the machined spring! Get a 2 M3k pens with machined springs + 1 case + 2 Bonus refills for $135
This... Read more
Machined Spring Prototype Done!
The machined spring is complete. Check out the video.
Why the spring? Mostly because of the smooth feel you get when writing! And it does help that it is cool!... Read more
Add a spring to your existing limited reward!
After some careful consideration, I have decided to make the machined spring available for those with the limited pen reward. Just add $35 dollars to your existing reward, and I... Read more
Prototype Machined Case Complete!!!!!
A Case worthy of the the best pens!
I'm very proud of this new case. It is verysolid, looks good and the ultimate display case! It is machined from... Read more
Machined spring design complete.
Spring Analysis and 3D model complete
After a lot of analysis, I have finally settled on a spring design that I feel will work. I really tried to make the... Read more
First Anodized Pens Completed!
Blue and Clear anodize samples are done
Hope you like them.. If you look close at the threads on the blue pen, I have machined the threads after anodize was... Read more
New! Optional Lanyard Slot done!
As promised, I have finished machining 3 more prototype pens yesterday with a Lanyard slot. It should work with your typical camera/phone lanyards. This will be optional to all pen... Read more
New Reward + status update...
TWO Machined Springs Pen Reward!
I never had a reward that gave some kind of discount to get the machined spring pen. A potential backer asked me about adding a... Read more
Update #1
New case design complete!
I am happy that so many have been able to support my project. As I stated in my video, I had planned on providing extras around... Read more


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OSU-Cascades, in partnership with The College of Business at Oregon State University-Corvallis, invite applications for a full-time, 9-month, tenured, Associate Professor faculty position. The appointment will nominally be made at the Associate Professor level, though appointment at the Full Professor level will be considered depending on the qualifications of the applicant. The person in this position is assigned to work at Oregon State University-Cascades, located in Bend, Oregon. The individual in this position will develop and lead a hospitality management program to be offered at OSU-Cascades.
Required qualifications include PhD in hospitality management from an AACSB accredited school or equivalent. Tenured in hospitality management at an AACSB accredited school or equivalent, and an existing record of scholarship that enables the granting of tenure at OSU. Demonstrated excellence in teaching hospitality management and mentoring of students.
Preferred qualifications include experience in curriculum and program development and assessment, professional certifications and a commitment to promoting and enhancing diversity.
To review posting and apply, go to http://oregonstate.edu/jobs. Apply to posting # 0009798. You will be required to electronically submit a letter of application describing your interest in the position and an overview of your qualifications and experience, a resume/vita, and the names and phone #'s of three professional references. For full consideration date is 11/30/2012. The closing date is 02/15/2013. Anticipated start date is March 16, 2013.This start date is negotiable/flexible to a June 16, 2013 through September 16, 2013 start.
For information regarding this position please contact Johannah Goodwin, Human Resources, OSU-Cascades at firstname.lastname@example.com.


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- About Extension
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Video Conferencing (Polycom/Renovo)
Polycom and Renovo tier 1 support is provided by Wayne Jardine and Victor Villegas.
ECTU supports this application.
- Renovo login page Renovo is the video conferencing scheduling application for setting up video conference bridge calls.
Recorded Training Sessions:
- Polycom HDX 7000: basics (Adobe Connect - 38 min)
Includes using the equipment, tips for having a successful session, etc.
- Renovo webinar (Adobe Connect - 35min, from June 2012)
Other Resources:
- Polycom HDX-7000: Quick Tips(PDF - 2.3MB)
- Polycom VSX-7000: manual (PDF - 2.2 MB), visual guide (PDF - 1.2MB)
- Polycom RealPresence Desktop for Windows: quick tips brochure (PDF)


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Liz Worthey's "smart software" crucial to integrating genome sequencing in clinic.
September 27, 2011 | On Saturday June 27, 2009, a pediatric gastroenterologist named Alan Mayer at the Medical College of Wisconsin (MCW) sat at his computer to type an email.
Mayer was at his wit's end. One of his patients, Nicholas Volker, had been hospitalized for the better part of two years, suffering from a chronic inflammatory bowel disease. Mayer entered the address of his colleague Howard Jacob, an expert on next-generation sequencing (NGS), and began typing:
"Dear Howard, This is a unique situation, one that comes along only every few years…"
He went on to describe the symptoms of a young boy, which included a colectomy, but the surgery site never healed. Feces leaked from his navel and holes in his stomach. He paid 90 visits to the operating room while he was just 3 years old. At age 4, he was taken off solid food and put on complete bowel rest. Immunosuppression therapy merely slowed the progression of the mystery disease.
Mayer signed off by asking whether Jacob would consider sequencing Nicholas' genome? If a mutation could be found, the immunologists could decide whether Volker would stand to benefit from a bone marrow transplant. Jacob met with a few of his colleagues, including bioinformatician Liz Worthey, to discuss Mayer's request. "We've been talking about how we could do sequencing clinically to help kids," he said. Here was an opportunity, albeit one accompanied by myriad problems, concerns, and ethical considerations. "Do you think you can do it successfully?" he asked.
"There was no point going down that road if it means another four-month saga for a family whose kid has already been in hospital for years, if we don't think we'll find anything useful," said Worthey.
The team said, "We can try."
Worthey Goals
Liz Worthey originally wanted to be an immunologist, but judging researchers' ability to understand the immune system to be a bit too complex, she shifted to genetics. She got into bioinformatics during her Ph.D. in genetics at Imperial College, London, in the pre-genome sequence era. "I liked it more than working in the lab," she recalls. She then spent several years in Seattle, working at the University of Washington and Rosetta, before being recruited to MCW by Jacob in 2008.
Initially, she worked on the rat genome database, but readily agreed to help with data analysis from the center's first NGS instrument (a 454 Life Sciences machine). "It sounded perfect to me," she said. "Finally bioinformatics has arrived."
As the cost of whole-genome sequencing (WGS) for Nicholas would have been about $1 million using the 454 sequencer, Worthey and Jacob opted for exome sequencing. The odds were still good that they could find the putative mutation, and it would simplify the clinical diagnosis by confining the catalogue of DNA variants to genes, rather than the entire genome.
Worthey pulled together an a priori list of 2,000 candidate genes. "We had a summary of the medical record, so I extracted all the disease terms, the genes they'd looked at and the drugs prescribed… I was sure it was in there. Turned out it wasn't!"
Faced with the task of whittling 16,000 DNA variants down to a handful of prime suspects, Worthey spent the next few months working with a team of programmers building a pipeline—a set of tools that would allow her team and before long, clinical geneticists, to build rational queries. She called it Carpe Novo (see, "Carpe Novo").
Seize the New
Worthey reasoned that Nicholas' mutation, which was obviously severe, would be a very rare mutation. Only one other child was known with similar symptoms—a British child with a mutation in the interleukin-10 gene. She also predicted that the mutation would be considered 'damaging' based on analysis using algorithms such as SIFT or PolyPhen.
She used the dbSNP database and other filters to whittle down the number of candidate genes, then excluded any that were documented in any other released human genomes. "We didn't think a 'normal' individual would have that mutation," she says.
That left two. One was a gene called GSTM1, involved in the export of toxins. But this gene harbored lots of potentially severe mutations in different populations. Much more interesting was an X-linked gene called XIAP, involved in the regulation of apoptosis (programmed cell death) and the inflammatory response. Worthey's interest only grew when a newly published paper showed that XIAP had a role in the NOD signaling pathway, which is involved in sensing bacterial peptides.
Here, then, was a candidate gene linked to the immune system (the regulation of cytokine response). She reasoned: "Something has happened in [Nicholas'] gut—some bacteria have turned on the immune system, and he can't switch it back off again. That's why it's destroying his intestines."
The mutation in XIAP altered a conserved cysteine residue—a critical site for mediating interactions with other proteins. "All species—from human down to fruit fly—have a cysteine [at this position] as well as 2,000 other human genomes," says Worthey. Because it was a clinical case, the mutation was confirmed using Sanger sequencing.
Inspection of the OMIM database revealed that XIAP mutations were associated with a different disease, an X-linked lymphoproliferative disorder, which leaves patients highly susceptible to Epstein-Barr virus infections. "It's particularly scary for a kid in hospital all the time," says Worthey. "A treatment would have been recommended on that, regardless of his GI issues. But it looked like it fitted with both."
Even finding the mutation wasn't sufficient, however; the transplant team wanted further proof, which came in the form of assay data from James Verbsky's lab as well as modeling data, indicating there was indeed a functional defect in the XIAP pathway.
Finally, pediatric geneticist David Dimmock logged in Nicholas' record that he had XIAP deficiency—a definitive diagnosis. Physician David Margolis made the recommendation for the bone marrow transplant. After receiving a second opinion, and seven months after his final diagnosis, Nicholas finally received a bone marrow transplant in July 2010. Despite some inevitable complications, Worthey says he is doing "really, really well." Six weeks after the transplant, he was finally able to eat solid food, including his favorite meal, steak with A1 sauce. Worthey remembers hearing that he had once said, "I don't care if I get sick, I just want to eat."
Nicholas was able to be home for Christmas 2010. There has been no recurrence of his intestinal inflammation, suggesting that the XIAP hypothesizing was correct.
Building the Pipeline
It was during a Grand Rounds presentation with Dimmock that Worthey sensed the pent-up demand among local physicians. "At the end, maybe half a dozen pediatricians came up to us and said, 'We have a child that we can't work out what's going on. Can you sequence them?'" Lacking the funds to sequence additional children, Jacob approached MCW and the Children's Hospital Institute for help. They responded by putting aside institutional funding for 20 cases.
But which cases would they be? "It couldn't be the first 20 we got," says Worthey. "We couldn't just do kids seen by clinical geneticists." It seemed logical to include other constituencies—ethicists, genomics experts, disease experts—to select suitable candidates. Worthey is the only non-clinical member of the review committee (see, "Review Process"). "We know the first time we do it we won't get it perfect, but we have to do it and seek to improve it every time we review another case," she says.
The committee meets every month, as it has since October 2010, and reviews 4-6 cases each meeting. "We discuss how full genome sequencing could affect the treatment of the child, the family, whether it's the right course of action. Have the correct tests been done in advance?" says Worthey. While it wouldn't make sense to do whole- or even targeted genome sequencing if another cheaper test could find the result, sometimes doing whole-genome sequencing first will prove more cost effective than running a battery of traditional single-gene tests. Worthey says those issues are discussed, but aren't the most critical factors.
Sometimes a case goes back into the "parking lot." "The person who brought that case to the committee is requested to do additional testing, or to refine exactly what they hope the test will add in terms of the patient care."
For now, the MCW team is outsourcing the sequencing to the Illumina CLIA-certified lab, while it develops its own CLIA lab in house. Illumina returns the list of variants and Worthey's group performs the analysis; subsequent interpretation is carried out by the clinical geneticist working with the patient and their family. Only after confirmatory sequencing of candidate mutations by the "gold standard" Sanger sequencing are variants put into the medical record.
Too Much Information
One of the most vexing debates concerns how much information to return to the family. In the end, the committee decided that the return of any or all genomic information is morally permissible, and that it should be left up to the patient's parents. "If we find a variant that's clearly associated with the onset of a disease in adulthood, we could still return that information to the parents if they so desired."
Worthey points out that for the family of a hospitalized sick child, the last thing they probably need to hear is that their child has an adult-onset mutation associated with cancer. "But that should be their decision," she says, in contrast to some medical centers that ignore certain genes because of the legal obligations to return that information to the family.
From October 2010 to June 2011, the MCW committee considered 45 patients for whole-genome sequencing. A few were definitely rejected, while others were sent to the 'parking lot' for additional testing. But half-a-dozen patients have been sequenced, with clinical geneticists conducting the interpretation using Carpe Novo. "We haven't had another case like Nic, where we made a diagnosis and there was a 'cure'. But we have had cases where we've made a diagnosis, and this has allowed us to help the family," says Worthey.
In one case, an infant was rushed to the ER suffering from hypothermia, hypoglycemia, and other symptoms. WGS revealed two pathogenic mutations in a gene called TWINKLE. A liver transplant was considered but ultimately ruled out. Although there was no effective treatment, the diagnosis brought some peace of mind: the clinicians elected to allow the child to live out the final months of its life at home in comfort, rather than extending the ordeal to no end.
In another case, a 16-month-old neurology patient with intractable seizures, WGS identified mutations in a known gene (TME67), indicating a non-classical presentation of Joubert Syndrome—but no obvious treatment. However, the finding enabled additional testing of other family members. "It's not that the cure is there, but it's very useful information," says Worthey.
A third case highlights the tricky problem of false negatives. "We have another immune deficiency, where we've pored over it and haven't found the answer," says Worthey. "The question is, have we sequenced the gene that harbors the mutation to sufficient depth? Or is it an alternative transcript? There's lots of reasons we might have missed it, but that's not a clinical diagnostic question in the timeline available to do this work." In this case, the patient had a bone marrow transplant, as a last resort.
One of the more remarkable aspects of the Wisconsin experience is the interest in pre-authorization expressed by an insurance company, which sees the value in the reduced cost of whole-genome sequencing. Some patients end up having many genetic tests done, sometimes totaling more than the cost of WGS. "The insurance companies are saying, maybe it'll be cheaper to do whole-genome sequencing off the bat. Under those circumstances, they've approved the WGS test as the diagnostic test."
Whether insurance companies will reimburse for the interpretation is another question again. "I'm not sure if the insurance company would pay for the interpretation part, but maybe now it is becoming cheaper, under these specific guidelines, they may consider paying for it."
There is no doubt that the MCW experience will be emulated at medical centers across North America and beyond. The MCW team has received many requests but has only taken patients at Children's—in large part because of licensing restrictions. "Our clinical geneticists can't take a patient from another state unless licensed there," she says.
Although early, Worthey sees many benefits of WGS: diagnoses will be made, diseases will be redefined, new treatments will be considered, and drug treatments will be adjusted. Adapting to a clinical setting has been eye-opening. "It's not like a research project, where you can meander along. You have to get these results in six weeks! The more we can do to make the life of the clinical geneticist easier, the better. It's taking them a long time to do each case. We want to sequence everyone. So the analysis is the crux of that."
"Making smart software, I think, is pretty important." •
Liz Worthey knew that the bottleneck for any clinical genomics case would be the sequence analysis. "We had to build a tool to annotate the variants we'd find," she says. She chose the name for her software because she was forced to do Latin at school. "I looked at all the variants for those 2,000 genes one by one over one weekend, to see if they were sequencing or mapping errors. It was a bit tedious. That's when Carpe Novo became the name."
Worthey was assisted by a large team of developers over 3-4 months. "It's not perfect but we've been working on it since then," she says. "It's basically a variant annotation tool—it doesn't do the interpretation for the clinical geneticist, but it does present them with all the information they would need to do the interpretation. Rather than having to go to lots of different web sites, which would take a long time with 3-4 million variants, it brings that information to one place. And it lets someone who doesn't have a lot of bioinformatics skill themselves run all those annotations on those variants and construct the query based on the information they know about the family, and return the low-hanging fruit—the most likely candidates."
The Carpe Novo software allows clinical informaticians to build queries. The end result is a variant report, with variants annotated for clinical interpretation. The software is also certified by CAP—the College of American Pathologists—and CLIA, providing end-to-end certification. "We thought we should do that if we're moving forward to do this properly. It's a very high level of quality assessment on the software, validating the data we get in house versus external algorithms, running controls. It probably took 3-4 months to have the whole pipeline—which starts from receiving a hard drive that contains the variants through to doing the interpretation." K.D.
Nomination: Any physician can nominate a case for review based on medical history, the diagnostic workup, and the goals of testing.
Committee review: The committee considers the potential for change in treatment with a diagnosis; the patient's medical management; establishes recurrent risks; and considers the medical and economic benefits of ending the diagnostic odyssey (the relative cost of genome sequencing compared to multiple single-gene tests).
Committee make up: Chaired by the hospital's chief medical office; the chair of the hospital ethics committee; an MCW ethicist; geneticist; genetic counselor; genomics/bioinformatics expert; and external physicians + nominating physicians. K.D.
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In the wake of heightened concern aroused by the death of a patient in a gene therapy trial last September, the National Institutes of Health (NIH) and the Food and Drug Administration (FDA) have launched two new initiatives to improve protection for patients participating in gene therapy studies. A number of such trials have been halted voluntarily by researchers or by the FDA.
Recent investigations have found that the clinical monitoring of some gene therapy trials had been "less than adequate," according to the two agencies. The first initiative, the Gene Therapy Clinical Trial Monitoring Plan, will intensify the level of oversight by requiring researchers to routinely submit their monitoring plans to the FDA for review. Trials will also be under FDA scrutiny to ensure that the plans are being followed and that monitoring practices have been adequate.
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Philadelphia Baptist Church telephone number is (386) 776-1392.
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Churches, in Live Oak, are buildings for Christian congregation and worship. The clergy disseminate teachings of Jesus Christ in these Christian churches.
Biofuel: Food In, Fuel Out, But Is It The Answer We're looking For?
(Long Island, NY) In today's environmentally-conscious worldview that is being shared by more and more people, alternative fuel sources are the Holy Grail of the "green" movement. There are many new ways to eschew hydrocarbon-laden gasoline when it comes to filling up your vehicle's tank at the pump, and one of the most oft-talked about are biofuels- mainly ethanol and..


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Tibetan ball
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Nice recording, thank you.
nice sample, thanks. used it here: http://soundcloud.com/mad_scientist_sounds/breakfast-paranoia-edit
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From infancy through the teenage years, the human body undergoes many changes and encounters many common childhood diseases. SJMO physicians are familiar with these and help to better steer our younger patients toward the healthiest of outcomes.
St. Joseph Mercy Oakland offers a comprehensive range of services for our pediatric patients and their families, including family medicine, pediatric cardiology, pediatric oncology, and an infant sleep apnea program.
There are many reasons to choose St. Joe for you child's care. Click here to learn more.
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Our 30-bed pediatric care unit allows SJMO doctors and staff to care for children from premature newborns through teens under a nurturing philosophy of family-centered care. Parents are encouraged to room with their child during the child's stay, and are provided with amenities, such as bedside sleep chairs and shower facilities. We know that visits from family and friends are very important to the recovery of children, and we encourage as many visits as we can.
In this spirit, we offer open visitation to those who members of the family feel it is important for the child to see, including siblings and grandparents. To learn more about family-centered care, please call 248-858-3400.
The services of a hospitalist and board-certified pediatrician are available 24/7 if desired by the infant / child's admitting physician. The hospitalist collaborates with the child's physician to direct quality patient care during the hospital stay. For more information, call 248-858-3400.
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SJMO offers a variety of Pediatric Specialty Clinics staffed by physicians, registered nurses, and other health care professionals. Pediatric Clinics include apnea, cardiology, developmental medicine, infectious diseases, and oncology.
To contact a SJMO pediatric specialist, call our referral line at 800-372-6094.


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At its annual shareholders meeting tonight, Tesla Motors' (NASDAQ: TSLA ) Co-Founder and CEO Elon Musk said that the Model S was the top-selling electric car in Q1 2013 and that its revenue was more than all the U.S. electric car revenue in the U.S. combined.
Musk also spoke briefly about the company's latest round of financing, saying, "We raised more money than we think we need." Musk stressed that if a future supply disruption occurred because of a natural disaster or a supplier bankruptcy, the company would still have money to keep going.
During the meeting's question-and-answer session, Musk said, "We're in great shape from a cash standpoint. Even if we suck at cash management, we'll be OK." He went on to say that the company wouldn't be poor at managing its cash.
Toward the end of the meeting, Musk fielded a shareholder question about how the company can build shareholder value while mass-producing electric vehicles at the same time. Musk said that he wouldn't do anything to compromise the company's long-term goals in order to bring short-term shareholder value, but that the two goals were aligned in the long term. He said, "There are obviously things we could do that would have a short term effect on the stock price, but I think those would ultimately be disadvantageous in the long term."


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Monographs on tuberculosis which devote considerable space to the physical diagnosis of this disease usually omit a discussion of cardiac displacements which are so frequently encountered in chests affected by infiltration, fibrous degeneration, collapse, shrinkage and cavitation of pulmonary tissue. Some mention is occasionally made of dextrocardia as liable to occur in extensive right-sided lesions, but minor degrees of displacement, which are so frequently taking place, are altogether forgotten. Some clinicians, however, have observed that dislocation of the heart occurs in pulmonary tuberculosis more often than is generally appreciated. Turban1 said that a displacement of the cardiac dulness several centimeters to the right, with or without displacement of the heart, is such a frequent symptom of moderate contraction of the right apex that he considers it a typical and cardinal symptom of right apical disease of some standing, and that it may be seen in many cases
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Hi Everyone,
I wanted to share a fun layout with you featuring Fancy Pants Be You collection. If you're not familiar with this line, you'll want to make sure to get a peek. It's full of fun and quirky colors and patterns. I thought it was the perfect collection to highlight some pictures of my daughter and friends being VERY silly (as usual) at their academic awards reception last June.
I did some stitching using black thread to coordinate with the black highlights in the patterns. I also fussy-cut some flowers from the papers to use as embellishments.
I used the pink heart that was part of the paper's pattern to act as a "hyphen" in my title. I thought it was a fun way to incorporate it into my layout.
Make sure to stop by Right at Home to check out this collection as well as all of the new lines coming in from CHA!! You'll be glad you did!


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Networks are about to get messy
14:15, June 2 2014
Are you ready for the future of connectivity?
We now live in a connected world, but that 'connectivity' is constantly evolving. How will it look tomorrow? Duncan MacRae picked the brains of Evan Kaplan, CEO at iPass - a cloud-based mobility management and Wi-Fi connectivity provider - to find out.
Who will own the networks of tomorrow?
There's no doubt that cellular networks will continue to be owned by the telcos. However, when it comes to Wi-Fi the answer isn't as straightforward. Wi-Fi is an organic thing that anyone can deploy.
As a result, we're starting to see power shifting from spectrum owners and traditional mobile network operators to 'real estate holders', such as airports, hotels, malls, retail locations, stadia, airplanes and the like. Most are taking their Wi-Fi networks into their own hands and are largely indifferent to who the network provider is. In addition, platform players are starting to come into this space. They can monetise Wi-Fi networks with advertising and services, and in the process, connect 'real estate holders' and business owners with their customers. The recent Google/Starbucks deal and some of the early Wi-Fi deployments by Microsoft's Skype and Facebook are revealing indicators of this trend.
At the same time there are a number of mobile network operators such as Orange, Zain, Etisalat, Telefonica and Deutsche Telecom that have seen Wi-Fi as an opportunity to complement their traditional voice and data services and increase revenues. When you consider segments such as the business traveller, who needs Wi-Fi for using high bandwidth applications like Skype and Salesforce when they are travelling abroad, the business case for operators becomes quite compelling.
Essentially, the very nature of Wi-Fi means that the only thing we can say with certainty is that ownership and management of the networks of tomorrow will be messy. With few barriers to entry and a number of different business cases for the deployment of public Wi-Fi, competition will be fierce. The winners will be those companies who can offer the user virtual networks on a global scale by creating a simple online experience where users can roam all over the digital world using a single ID and password.
Source: Company Press Release
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The Honest Kitchen's Force is a delicious grain-free offering for adult dogs with dog food allergy concerns or adult dogs who are intolerant of grains. Force is formulated with moderate protein, higher fat and total calories, with a moderate level of carbohydrates. Great for sensitive dogs or those with moderate activity levels.
Honest Kitchen uses eco-friendly packaging! A fine, recyclable 'minimalist' and unprinted barrier bag that efficiently protects the food inside helps reduce materials usage and waste. The bag is enclosed in a 100% recycled box made from unbleached kraft paperboard. The box is printed with soy-based inks and the finished product is 100% biodegradable or recyclable again after use, too.
The Honest Kitchen makes wholesome, natural food for dogs using gentle dehydration, a unique new approach to canine nutrition. These foods help you create delicious and nutritious meals made with real, recognizable, and human-grade ingredients that are ready to prepare and serve at home. Simply add warm water to rehydrate, and you have a complete meal with USDA meat, fresh fruits and vegetables, organic flaxseed, herbs, vitamins and minerals.
The Honest Kitchen's dehydrated food offers many of the benefits of a biologically appropriate raw pet food diet, combined with the convenience and peace of mind of a nutritionally balanced, ready-blended product. Dehydration simply removes the moisture, which prevents decomposition. As an ancient form of preserving food, virtually all of the nutrients are left intact. This is a much "fresher", and therefore healthier, approach than the extrusion process that dry kibble undergoes. See below for a description of each formula.
All of Honest Kitchen's dog food and dehydrated raw dog food products are formulated to meet the AAFCO nutrient profiles for dogs and you don't have to add anything to make them 'complete'. However, the original idea behind these diets was as a base for a raw or other fresh homemade diet and to facilitate that, they are somewhat 'lite' in terms of fat and protein, so that your own choice of raw, or cooked, meat can be added, if desired.
It is entirely a matter of personal choice (and your dog's taste!) whether you add in extra meat and other ingredients, or not. Most people with younger and more active dogs like to mix in the additional meat, and those with senior or overweight animals usually prefer to feed the organic dog food alone. The Honest Kitchen supplies pet owners with the best in fresh dehydrated raw dog food and other organic dog food products.
About Dehydration
Dehydration or drying, is one of the oldest and gentlest methods of food preservation. Food dehydration works by removing only the water content from the ingredients. All other nutrients remain, and become highly concentrated. Dried foods are extremely nutritious, easy to prepare and store, and light weight to ship.
Because dehydration takes place at moderate temperatures, the ingredients are still considered raw. The only exceptions are the meat and egg ingredients, which are dehydrated at high enough temperatures to kill any bacteria present and are therefore essentially considered 'cooked'. This is because they must be human-edible grade, to enter our manufacturing facility.
The removal of moisture prevents enzymatic activity, which can lead to browning and decomposition of foods, and also prevents the growth of bacteria, yeast and molds. Dehydration does not actually destroy or kill the food enzymes, as occurs in baking and freezing or high pressure processing such as extrusion. Enzyme activity in dehydrated foods is simply suspended, until the food is rehydrated.
A remarkable example of the way dehydration preserves without destroying, is in Africa, where scientists have discovered live fish being hatched from fish eggs, that have been dehydrated in the sun, during droughts that sometimes last for years. When the rains fall, the lakes and rivers refill with water to rehydrate the eggs - and live fish emerge. The eggs are actually preserved and remain viable throughout the natural dehydration that takes place.
Review Rating: 4.5
Country of Origin: USA
Manufacturer: Honest Kitchen
Ingredients - All ingredients dehydrated: Chicken, organic flaxseed, potatoes, celery, sweet potatoes, apples, organic alfalfa, organic kelp, honey, pumpkin, green beans, cabbage, bananas, papayas, basil, garlic, tricalcium phosphate, choline chloride, zinc amino acid chelate, vitamin D3 supplement, vitamin E supplement, potassium iodide, potassium chloride, iron amino acid chelate, copper amino acid chelate
Feeding Guidelines
The following suggested dry-measured amounts should be adjusted to suit your own dog's unique nutritional requirements, which will vary according to age, breed, level of activity and what other ingredients are added. Force may be fed ad-libitum during growth, gestation or lactation.
The reviews below are presented for informational purposes only and are not intended as an endorsement of any product. The information is not intended to be a substitute for visits to your local veterinarian. Instead, these testimonials offer the reader information and opinions written by pet owners and/or veterinarians concerning animal health and products that they have used.
(based on 68 reviews)
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Great food
By GG
from Callahan FL
About Me Long-time Pet Owner
Comments about Honest Kitchen Force Grain-Free Dehydrated Dog Food:
I order a second one because my 2 English Bulldogs loved it so much. Easy to prepare and smell good
Bottom Line Yes, I would recommend this to a friend
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(0 of 1 customers found this review helpful)
Very Happy!
By Deuce's mama
from Seattle, WA
Our yellow lab was not appearing very happy or overly healthy. He was having skin issues as well. We switched because a friend made this recommendation and we couldn't be happier! His skin is in great shape, he is energetic and happier than he has been in a few years!
As close to feeding raw as you can get
By ES Owner
from Fredericksburg, VA
I have been feeding canned grain-free dog food for years to my three dogs. I liked the vconvenience of kibble but had noticed that canned food is rarely recalled and I liked that it has moisture. But using canned food is a hassle because of weight, space requirements, shipping costs, etc. When my oldest dog started getting feeble, one of my friends shared how her older dog had responded to Honest Kitchen Force so I started giving it to my old boy, too. He loved it, regained some weight he had lost and was peppier. I kept him on it until he passed away. My other two dogs were delighted to finish up my supply of Honest Kitchen! With just two dogs of different weights, it became difficult to feed them correct amounts of canned food - ¾ can for one, ½ can for the other meaning there was always leftover canned food to put in the fridge and use next time. With Honest Kitchen I can measure out exactly how much to feed each dog and can make it as wet as I want, hide pills in it and they eat everything and lick their bowls clean. Yes, it's expensive but the convenience and quality make it worthwhile. and I now how so much more room in my pantry!
Excellent quality food
By JT
from Wisconsin
I used to feed raw but had to switch 2 years ago and initially I fed only dry food. After switching my dog was always dehydrated and I had trouble controlling her weight. I decided to try Honest Kitchen and it was the best thing I could have done for her. She's no longer dehydrated, he coat looks better, she has more energy, and it's easier to keep her weight under control. It's expensive so I only feed her Honest Kitchen in the morning and then a high quality dry kibble at night, but eventually I'd like to switch to Honest Kitchen completely. It's WELL worth the extra cost over dry kibble if you can afford to make it work.
Honest Kitchen Force dog food
By ms anne
from Birmingham, AL
Dehydrated food seems to be the way to go for my dog. She eats every bite and food seems to agree with her digestive system. I feed my dog twice a day, morning and evening. In the evening I mix Iams dry food with dehydrated. This allows more expensive dehydrated food to last longer.
(1 of 1 customers found this review helpful)
I will buy this product again and again!!
By TAZ
from Arkansas
My dog is 14 and had extensive dental procedure to remove a lot of teeth. He has trouble eating any of the dry dog foods now. This is a perfect alternative to wet food because it has all the fiber and nutrients he needs. Thank you Honest Kitchen for a great product!
Great product, healthy and dog loves it!
By Tucker's Mom
from New Jersey
My sensitive dog has done beautifully on this food, not one issue since he began eating it.
Love Honest Kitchen
By Rebekah
from Napa
I really love Honest Kitchen. I have 2 Bostons and they do really well on this mix. Only problem is that my little girl is too fat. Will try another Honest Kitchen mix that is better for senior dogs. But I will stick with honest kitchen. LOVE LOVE LOVE this brand.
LOVE that my picky dog loves his food!
By Turnerflorida
from Florida
Tried Embark first and thought it was too much protein for an 8 year old. So this time I tried Keen. My dog stuck his nose up at first because it wasn't his beloved Embark, but once he took his first bite, he's been doing the same happy dance. I can tell you that both stopped the weekly upset stomach my dog was having; however, I did notice that Keen was producing much more poop. Probably the oats. Anyway, 4 times a day and 2 or 3 times on our nightly walk is way too much. I'm going to try Force this time.
Fantastic food, great quailty
By SmokeyandPebbles
from Tacoma, WA
So far all of Honest Kitchens dog food's have been excellent quality. We buy at least three different types of dog food from Honest kitchen per month. Grain Free diets/Love/Embark/Zeal/Force Chicken/ all of which I have rated a 10 out of 10.
© 2016 Only Natural Pet LLC - All Rights Reserved


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Honesty is best policy
How much money do you have to spend? Easy. Count your notes and coins and the balances of all your bank accounts which provide money on demand.
You could spend using credit cards or an overdraft or take a loan, but that's credit to be repaid, not money on hand. You might look at assets you could sell for money, but again, you would know they were not money itself.
Ask economists how much money there is and you will get many answers. You know money is what you can exchange for real goods and services, but economists often include things like time deposits, which cannot be spent because they have fixed terms. Money is one half of every transaction, so its supply really matters. According to my colleague Dr Anthony J Evans of Kaleidic Economics, the Bank of England's preferred measures, "Narrow Money" and "Broad Money", are either too narrow or too broad. From the perspective of the Austrian School of Economics, Anthony, together with entrepreneur Toby Baxendale, chairman of The Cobden Centre, has established and now publishes a different measure which they call "MA". A chart (see above) of the growth of MA shows a pattern that is not visible in the Bank of England's measures.
We built society on an expanding supply of money - on credit. When that expansion ended, we had an almighty crisis. Despite quantitative easing (QE) money kept on dwindling. Now QE has worn off and we are in yet more trouble. The answer is not more money printing but asking why we need ever more credit. What would the world look like if we produced, saved and invested?
Some values survive the centuries: dishonest money dwindles away, but he who gathers money little by little makes it grow. If we are to exit this crisis into an era of sustainable prosperity, we will need honest money. A good start would be to count it well.
Steve Baker is MP for Wycombe and a director of The Cobden Centre, an educational charity for social progress through honest money, free trade and peace.


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Reach First-Time Homebuyers
Help first-time homebuyers navigate the complex home-buying process. Use these valuable resources to:
- Learn more about our mortgage products and training opportunities
- Help first-time homebuyers get started
- Assist business sources in preparing mortgage-ready homebuyers
Product Information and Training
Create momentum for your business in the purchase market arena by offering first-time homebuyers mortgage options that meet their needs. We have competitive and prudent mortgage solutions for mortgage-ready borrowers, even those with limited funds for down payment.
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Super conforming mortgages. Increase your market penetration with affordable financing options for homebuyers who are looking to buy their first homes in high-cost areas.
Loan Prospector® Functionality. Use these resources to better understand how Loan Prospector works, and how it can help you process more loans.
Super conforming mortgage training resources. Take advantage of our educational resources to become familiar with our purchase and delivery requirements for super conforming mortgages.
Condominium Projects Eligibility Requirements. This 90-minute interactive webinar will provide originators, processors, and underwriters with a high-level overview of Freddie Mac's requirements for Condominium Unit Mortgages.
Acceptable Source of Funds. In this interactive 90-minute webinar we will review our requirements, guidelines, and policy changes for asset calculation and documentation to help ensure that borrowers have acceptable and sufficient funds.
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Grow Your Business Sources
Strengthen your relationships with real estate professionals, brokers, correspondents,and housing counselors by offering borrower outreach materials that help these business sources better prepare borrowers for homeownership.
Get the Facts on Homeownership. Help your business sources conduct interactive workshops to help dispel common myths about homeownership that prevent people from exploring the possibility of buying and owning a home.
Pursue Your Dream of Homeownership. Share this article with your business sources for use on their web site, in a newsletter, or as a handout. Simply cut and paste.
- Customizable Postcard. Download this artwork, customize with your logo and contact information, print, and distribute to your business sources.
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Learn more about available programs that can help qualified homebuyers – including first-time homebuyers – bridge down payment and closing cost gaps in the Explore Down Payment Assistance Options section.
Reach Borrowers
Take advantage of these resources to expand your reach and assist first-time homebuyers with the homebuying process.
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Do You Picture Your Child in Their Own Home One Day?
Paint the Walls Any Color You Want.
Understanding Automated Underwriting. This customizable marketing brochure provides details for your borrowers about automated underwriting and the role it plays in the mortgage process.
- Your Step-by-Step Mortgage Guide From Application to Closing. With Your Step-by-Step Mortgage Guide, you will find just about everything you need to help homebuyers navigate the mortgage process so that they take the right steps to purchase their home.
Customizable marketing materials. Enhance your first-time homebuyer borrower outreach efforts with these pre-designed marketing materials that you can customize with your logo and contact
- Instructions on How to Customize the Marketing Materials
First-Time Homebuyers: It's a Great Time to Buy. Share this article with first-time homebuyers who are looking for market information and practical homebuying tips. Use this article on your web site, in a newsletter, or as a handout. Simply cut and paste.
Online Homeownership Guide. Direct your borrowers to the Freddie Mac Online Guide to the Homebuying Process for valuable information on homeownership by adding the link, www.FreddieMac.com/homeownership, to your website. It is important that you review our Linking Policy.
Homeownership Education Materials. Use these high-quality educational materials about the various stages of the homebuying process to increase the number of mortgage-ready borrowers. Customize these materials with your logo and contact information, and get the most marketing impact from these pieces while helping pave the way toward successful homeownership for first-time homebuyers.
- Instructions on How to Customize the Marketing Materials
Additional Resources
Learn more about available programs that can help qualified homebuyers – including first-time homebuyers – bridge down payment and closing cost gaps in the Explore Down Payment Assistance Options section.


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The Robert Chalves Explosion will play at the Oxford in Snohomish Apr. 19-20. Call (360) 691-7799.
Forecaster's Public House at the Redhook Ale Brewery will present the Brian Butler Band playing rock and blues Apr. 19. Hear more blues by Lonesome Jerome Apr. 20. Times for both shows are 9:30 to 11:30 p.m. Pont-No-Pont will play acoustic string Apr. 22 from 7:30 to 9:30 p.m. No cover: 483-3232.
Grazie Ristorante at Canyon Park presents jazz and funk sounds by Blue Bossa with vocalist Keahi Matsui Apr. 19-20 from 8 p.m. to midnight in the lounge. No cover. For dinner reservations or information, call 402-9600.
The Eastside Comedy Club at the Kirkland Roaster & Ale House will present Showtime TV's Geoff Young Apr. 19-20 at 10 p.m. Mike Capp and Jay Hitt will open. Tickets are $7.50. Call 827-4400.
Late Night in the Market will present foot tappin' funk and rhythm and blues Apr. 19 and the Mel Cooleys Apr. 20, 7:30-10 p.m. Both shows are free, for all ages, and are non-smoking. Call 644-1111.
Latin-jazz percussionist Pete Escovedo with special guest Sheila E. will entertain at Dimitrious's Jazz Alley through Apr. 21. Call for times: 441-9721.


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We do not use flatpack or pre-made units. Your kitchen is built by hand.
Every kitchen is delivered by us and in our trucks within 12 working days.
Our friendly installation team will fit your kitchen exactly the way you planned it.
With over 30 years of experience in the kitchen industry, ours is a name that you can trust.
Where possible we use only 100% recyclable materials.
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