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This family-friendly Daytona Beach hotel with "stunning views" (Oyster.com) is exclusively cutting rates by more than 45% for Travelzoo members.
Travel through Dec. 24, 2016
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Daily Oct. 2 - Dec. 15
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Travel options Sept. 18 - Nov. 26
Fall, winter or spring -- it's always a great time for a trip to Lake Geneva, especially when you save on a stay at one of the state's best resorts.
Daily through March 31
Save 50% on this posh adults-only resort puts guests up in airy beachside cottages, featuring four private beaches, two pools and full breakfast daily
An resort amid the "unspoiled beauty and warm waters" (Frommer's) of Grand Bahama Island is offering up to 40% off.
Sept. 20 - Jan. 31, 2017; 3-night stay required
All-inclusive living awaits at this swanky, all-suite beach resort with a Jacuzzi in every room and a wide variety of on-site activities.
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Save 50% on a yoga retreat package including meals and two classes a day at this tranquil resort just south of Puerto Vallarta
October 1 - Jan. 7
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Oct. 5 - Dec. 22
Save 65% on three-night stays at an intimate, 4-star boutique hotel set on a private beach with all-inclusive upgrades
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Located on Alvarado Street -- downtown Monterey's main drag -- this hotel is celebrating the addition of a brand new wing with a spa special.
Midweek through Dec. 22; +$40 weekends
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Fastest cars on the road
POSTED: 12:47 PM PDT October 29, 2012 UPDATED: 7:13 AM PST January 13, 2014
When looking for a car, some people have one main question – how fast can this car go? Take a look at some of the fastest cars and their top speeds.
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subset: commoncrawl


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The Institute for Supply Management�s (ISM) September report shows an increase in the September�s Purchasing Managers Index (PMI) from August�s reading of 55.7%. September�s PMI reading of 56.2% is the highest of the year, leading to an average PMI� reading of 55.8 percent for the third quarter.
New Orders, a leading index of future activity, declined from 63.2% to 60.5%. While still in a positive direction, it is one to watch.
For the full ISM report see it here.
Meanwhile in the UK, manufacturing activity eased slightly as reported in the Guardian. In Germany, the PMI dipped to ...
Read more


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discreet billing & same day shipping
Customer Reviews
Amazing and fulfilling!!! Review by Peter
I don't want to let my husband know about it since I complained when he first started toying with the extender, but now I cannot wait for him to use it. I am actually disappointed when he does not put it on but does not want to tell him out of fear that he will feel that I reject his thin cock. I at least know that it is still his cock in me as well. The stretch it gives my vagina makes me climax over and over. Sex has never been so great!!! (Posted on 7/12/12)
She likes it! Review by Mr. Average
My wife is very shy and she won't even look at toys like this. It took a while to get her to try it. Finally, she gave in but the first time was a little rough - I could only get a few inches in her and she wanted to stop.
The second time I warmed her up with a smaller toy first and when we got to this one, she eventually took it ALL. Afterward, she was trying to act like it wasn't a big deal (and she "likes my dick better"), but I could tell she was having a VERY good time when it was buried deep. Just knowing that big fucker was in her up to my balls pulled my trigger quickly. What a turn on! She won't talk about old boyfriends and their sizes, so I assume that means I'm not the biggest she's had. Pretty sure I am now though :)
Later I tried to get her to look at it and she wouldn't. I held it up next to my dick and put her hand on me and then on it..."Holy shit! It's frigging huge!" she said. "And every inch of it fit inside you" I told her. She couldn't believe it...I could tell she was turned on by the size. It's the main event here now and we always warm up with smaller stuff, it's pretty damned girthy.
I've searched the web and I see it is SOLD OUT on every sex toy shop that lists it...I hope they didn't quit making it!
(Posted on 6/11/12)
Fantastic Review by OMG
My wife absolutely loves this one. It stretches to about 2 1/2" wide when I'm in it and is SUPER soft. Soak it in hot water and put lots of lube on yourself before putting it on. Because of it's girth, it takes a few minutes to get it in her - really stretches her wide. She goes nuts when we're finally all in and rock'in. She loves the soft material and 2 kids later, this completely fills her up. No problem for me coming with this on, it feels great for me too!
We have another skinnier toy for "length" (9") and this is the one we use for "girth" (I cut this one down to 8" because she couldn't take any more than that at this girth). She was reluctant to try this, but now after me pumping away for a little while to warm her up (just me to start out), she's ready for a "wardrobe change" she calls it. I need to buy another now and try a little more length!
(Posted on 6/10/12)
saved our love life Review by jenny and tom
we have been married 12 years. We are intimate about 1 time every two months. my husband bought this to surprise me and I was surprised. We have a good relationship but with work and stress we just stopped having sex. This toy reminded me of some times I had in college with a guy of similar size and my husband knew about this because we are honest with one another about everything. That time was Ok-good, but this toy is on a different level. yes it has size but it is the control you get with your partner that makes it unbelievable. what worked for us and I would recommend is to have him put it on which is easy by squeezing the end. Then get excited however you do that. Shouldnt be a problem because this thing is very lifelike. Then have him stay in the same place until you get the first couple inches inserted which may take a few minutes. After that you can really start going and it is big but if you cant take the whole thing you should get within an inch or so because it has a softness to it. For the past couple months we use it about 2-3 times per week now and it is holding up well. And since he cares about giving me this pleasure I have started making it a point to reciprocate. Even better is I ask him to use this a few times a week but now we are intimate daily if not multiple times a day. Overall no other toy has done so much for me. Also, you need to warm up with this toy. It is too big to just start right at it. But that is half the fun. Also, I think guys just really enjoy seeing how much you can take and also to see how many times they can get you off and how easy it is with this toy. It is a must buy. Anything bigger would be painful. (Posted on 11/25/11)
impressed Review by impressed
my first disclosure is that i bought this product from another site so I dont know how this sight is but the product can't be beat. I didn't comment on the other site because they require email and a name and I dont care to have that info out there for everyone on a sex site. I dont know how everyone doesnt get one of these. Even if you dont have a man you can just use this on your own. It is not quite sturdy enough but if you put something it it then it works just fine. I put a bottle of hair product in mine and it worked like a charm. However when you use it with a partner it is earth shattering. Go slow. At first when my boyfriend showed me I told him no. He ended up tying me up one night and under the covers he did oral for a long time. Then he turned me over and retied my legs. He just held it there and I could feel it but I thought it was him. He had me so excited so I started to push back on it. To be honest it didnt go in. But then once it started I had to stop and breath... It took maybe 2-3 minutes just sitting there but then I started moving again. I knew it wasnt him because he isnt blessed in the size department. This thing is slightly bigger than the two biggest guys I was ever with though. Once moving on it I got off in about 2 minutes which was my first vaginal orgasm. The other nice thing is my boyfriend normally lasts about 3 minutes and instead we had sex for over an hour and a half. I will admit I am walking a little funny today but I would guess that I got off somewhere close to 60 times last night which also beats my record of 4 times in one day. By about half an hour you should be able to take the entire thing. I was shocked when I felt his abs start hitting me because I thought I would have only been able to take half of this thing which is initially what happened.
In short:
Just huge enough that it challenges you but opens new worlds in pleasure once things get going.
stays on well compared to other extensions
thicker than other extensions
doesn't have the floppy head
bf says he got off once from seeing me and feeling the squeeze and was able to keep going with it till he had another erection and I didnt even know.
Scary to see at first. Actually turned me on but I was reluctant to try it.
Takes care. Must clean it with water and put powder on it after to keep it soft.
your partner might not like it. glad mine loves it.
Just so you know it doesnt vibrate ( wasnt a problem for me because nothing has gotten me off so much as this thing)
If you do get this thing you should definitely comment on the site. i can't imagine someone not absolutely loving this thing. (Posted on 11/23/11)
omg. most amazing toy we ever used Review by hubby
To put this shortly. The look on her face you will never forget. My wife is pretty small. She always says she only likes me and doesnt like toys. She said if she got drunk she would try it so we got drunk. After toying with it for a minute she told me to put it in. She instantly had an orgasm and was clutching the sheets. Her eyes rolled back in her head and she couldn't talk. After ten minutes she was telling me to give it to her harder. I was impressed because she doesnt normally like toys and she only weights about 115. We are both in our 20's and she hasn't had kids just so you all know. This toy can be used by all girls but I will tell you that it is bigger around than all the other cyberskin extensions on the market. You won't be dissappointed if you get this but you may be shocked by the look on your girl's face. Don't know how guys would like this cuz im not gay. As for the guys feeling, it is a little dimished. there is a squeeze because it makes your girl feel way tighter. You don't have the feeling of slipping in and out though. It could make you get off just because it is such a turn on to see how your girl reacts. After seeing her squirm I found my new favorite porn. Too bad there are no videos showing extensions in use. Even girls in porn would not be able to not have several orgasms with this thing. (Posted on 11/18/11)
wow Review by lisa
This thing is absolutely amazing. I didn't let my husband know that but I dont argue when he wants to use it. It feels real and is the thickest real extension out there. It is thicker than the normal cyberskin extensions. When the husband goes to work every day I have used it over a small didlo and I can get off almost instantly. It would be easy to have 10 orgasms a day with this. The husband loves it but I tell him I like him better. :) We have never had a toy this big and I dont want him to think I need a bigger guy but wow! The pictures don't do this thing justice. You really need to see a video of this thing in action. No I won't supply that video. I'm surprised there aren't more reviews. best extension I have ever used and can't say enough about it. (Posted on 11/5/11)
update Review by john
too big for her. but she says not to get rid of it. (Posted on 11/1/11)
this thing is amazing Review by john
I haven't used this yet with the gf, but I have tried it on. This thing is massive. If you want something bigger than the other cyberskin extensions this is your ticket. It doesnt have the same floppy head the others do. It is thicker. It has nice texture on the outside. It fits perfect and is much easier to put on... There is no need to role this thing on... this one you just squeeze the air out and everything slides in if you use cornstarch. I know the gf will be a little shy about this one so I need to think of something. Blindfold, tied up, a little drinking... who knows but it should be fun! (Posted on 10/20/11)


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Our deluxe comfort custom window seat cushion with buttons is both comfortable, stylish, and one-of-a-kind. These custom designer-quality cushions are both elegant and functional, finished with optional decorative buttons. We have hundreds of fabrics to choose from to design your ideal window seat cushion. If you don't find the fabric you're looking for, you may send us your own fabric (COM). Measurements do not include thickness of welting.
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Arguments on both sides of the issue of raises for Altoona Area School District administrative employees were valid, although not all were in the best interests of taxpayers.
At a meeting last week, the board voted 5-4 to give automatic 3 percent salary increases for 2014-15 to about 70 employees. Meanwhile, a 2.5 percent raise was approved for Superintendent Thomas Otto, while Assistant Superintendent Mary Lou Ray was granted a 2 percent hike.
Next year, the board should re-evaluate its thinking on this matter, including taking into closer account how raises being considered stack up against raises being granted in other area businesses, industries and service providers. As a result of last week's action, many people who have lost their jobs or endured cuts in pay and benefits as a result of the sputtering economy are being required to subsidize increases they might construed as excessive when stacked up against the increase in the cost of living.
The financial situation of senior citizens and others on fixed incomes has been made more difficult, as well.
The most perplexing part of the raise action is that it came amid the uncertainties of what money will be coming from Harrisburg for 2014-15, as state lawmakers again seem destined to drag out state budget decisions until the last hours of the current fiscal year, which ends June 30.
The last two years have been especially financially challenging for school systems. Although this is a legislative and gubernatorial election year, a year when Harrisburg traditionally has found a way to make more money available to education, it's unlikely that any additional 2014-15 money will be enough to erase the difficulties that the past two years imposed.
However, the new year beginning July 1 might be an opportunity for school systems to add a bit more stability to their fiscal operations, if districts are tight-fisted in their spending.
Although the Altoona district's administrative raises total just over $140,000, some of that money could have been redirected to benefit students if the board had voted on behalf of smaller increases. It's a time when every dollar counts.
But there was truth in both sides of last week's discussion.
For example, Board President Maryann Joyce Bistline correctly pointed out that "we have some valued employees at this district, and we need to make sure we appreciate their hard work."
But board member Sharon Bream also correctly observed that "salary increases should be based on the community you live in."
On that basis, Bream's thinking that "3 percent is too much" makes sense.
Over the years, regardless of the district's financial circumstances, Altoona teachers have been treated generously - oftentimes, too generously, from hard-pressed taxpayers' standpoint. However, that didn't prevent one teacher at Monday's meeting from lamenting the board's action to "quickly push through substantial raises to people already earning a lot of money."
It's appropriate to point out that district teachers' salaries hardly classify them as needy.
Whatever the board's pay-increase decisions, it's the taxpayers who end up paying. Between now and next spring, the board should do more financial homework reflecting the tough realities with which taxpayers are dealing.


text: Applebee's By Sparkle Picnic There's nothing better than getting some groceries and heading home after a... more »There's nothing better than getting some groceries and heading home after a long day at work. This is a long cut of a bit we filmed for submission to The Ten Second Film Festival (http://www.soapfactory.org/) "Like" us? - http://www.facebook.com/sparglepignik Visit the website - http://www.sparklepicnic.com « less Published May 02, 2012 216 views More Info » Full Credits Sparkle Picnic Uploader Stats & Data 2 Funny Votes 0 Die Votes 216 Views Published: May 02, 2012 Categories: Web Series Not Safe For Work Sketch Keywords: sparkle picnic applebee's safe word rape fantasy role playing love quarrel scary rapey comedians comedy writing sketch shows slapstick stand-up comedy skit collegehumor college humor snl all that madtv mad tv mr show sketch show mpls minneapolis minnesota peep show Up Next: Sparkle Picnic: Edible Puppy (episode #5) AUTOPLAY Up Next In: 10 Sparkle Picnic: Edible Puppy (episode #5) You're Not Funny Cat In A Box Sparkle Picnic: Space-Docking (Episode #6) Follow Facebook Twitter Tumblr Instagram Browse Related Comments 240+ more View All ▶ Sparkle Picnic Vaguely Related Videos Vaguely Related Pics & Words Advertisement Tags: sparkle picnic applebee's safe word rape fantasy role playing Advertisement


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Landmark legislation restricting abortion in the state of Texas is getting the attention of legislators across the country.
The new bill, signed into law Thursday by Texas Gov. Rick Perry, may serve as a model for other states to follow. The bill, known as HB2, restricts abortions and abortion clinics in the state.
"This is a momentous day for the cause of life," Texas Rep. Jodie Laubenberg (R) said.
"This will literally change the lives of millions in Texas," State Sen. Glenn Hegar (R) added.
That's because the Texas law requires that most abortions be performed within the first 20 weeks of pregnancy.
"At five months, many studies indicate these children feel the pain of their own deaths," Gov. Perry said. "It is our responsibility and duty to give voice to the unborn."
Pro-abortion supporters say the law hurts women.
Katherine Miller volunteers with the Lilith Fund for Reproductive Equity, which helps low income women pay for abortions.
"They are doing everything they can to destroy any kind of rights that women have for bodily autonomy," Miller said.
The legislation also requires abortion clinics to follow health regulations for surgical care and mandates that individuals performing abortions have admitting privileges at local hospitals. Only five of 42 Texas abortion clinics currently meet those standards.
"Clinics that don't comply, they don't shut down," Texas Lt. Gov. David Dewhurst said. "They continue to provide women's health (care); they just can't provide an abortion."
A group of pro-abortion advocates rallied at the Texas state capitol building. They insist the true goal of the Texas governor and Republican legislators is to prevent legal abortions in the state.
"My hanger is a wire hanger because that's what we're going to go back to if women do not have access to safe, legal, accessible abortion," Miller said.
But Gov. Perry insists the new law is sensible.
"At the end of the day, House Bill 2 makes sure that anyone performing abortions in the state of Texas is doing so in a facility that meets appropriate safety guidelines," he said. "That is reasonable. That is common sense."
Moments after the governor signed the bill into law, Planned Parenthood announced it will close three of its Texas clinics in Bryan, Huntsville, and Lufkin.
The law goes into effect in October. But Texas abortion clinics have until September 2014 to meet the new guidelines.
Texas Abortion Supporters: 'The Fight's Just Begun'
Texas House Gives 20-Week Abortion Ban Final OK
Texas Again Gears Up for Nasty Abortion Fight
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Camille Cerria has never been so excited about football.
Correction: Before now, the nautical event planner has never been excited about football.
All that changed when her Hoboken-based company, Smooth Sailing Celebrations, was chosen by the NFL to host four days of Super Bowl press events aboard its spectacular Majesty yacht, which is billed as the largest party boat in the country."I think (the NFL) really wanted a unique venue and there's no more unique venue than a boat," said Cerria, whose company is marking its 10th year in business. "Especially this boat, because of the atrium-style ceiling and everything else that it has to offer."
The 45,000-square-foot Majesty boasts tremendously high ceilings and each of the four decks has an immense amount of open space filled with elegant tables, fireplaces, a cocktail bar, and even a working elevator.
Cerria called that a perfect fit for the NFL, which hasn't provided many details but will be using the Majesty from Jan. 27 to 30. She said the yacht will be docked in front of the Hyatt in Downtown Jersey City, where one of the Super Bowl teams will be staying.
Having the perfect venue -- with a perfect view of the New York skyline -- was half the battle, Cerria said. The other half is knowing the right people.
Her company has a strong relationship with the Westin in Downtown Jersey City, which will host the other Super Bowl participant. She was referred by officials there to the NFL and the rest, she hopes, will be Super Bowl history.
"Relationships are really important in this business," she said. "I advertise, I market, I network, and that's all well and good, but I think that the relationships that we have are really what make our company what it is and what really drives business to us.
"Word of mouth, people trust it."Cerria became an even bigger NFL fan when the San Francisco 49ers, the Denver Broncos and the New England Patriots -- three of the four teams vying for a spot in the big game -- contacted her about potentially hosting their private parties aboard one of the yachts.
"I've never been so excited about the Super Bowl in all my life," she said with a laugh. "And now I feel as if I'm invested to see which team's going to win and how their party's going to be."


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• Assessments of medical technologies with respect to their efficacy, safety, and cost-effectiveness are expected to influence clinical practice, but they are often lost in an avalanche of medical information. We developed a conceptual model that may aid understanding of the potential impact on clinical practice of new medical information in general and assessment information in particular. The model identifies aspects of medical communication that may influence an assessment's subsequent impact, including sources, messages, channels, audiences, and settings. We reviewed the literature on how medical information diffuses to physicians and highlighted those factors likely to heighten physicians' awareness and decisions to incorporate recommended medical advances. We outlined implications for educational interventions and promising research directions.
(Arch Intern Med 1985;145:314-317)
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Since October, "LOL@ MACC" has brought top comedians from around the country to Maui for unforgettable one-night-only performances. The series has featured Chris Franjola, Bret Ernst and last Saturday, Las Vegas-based comedian Rita Rudner.
Rudner, voted "Best Comedian in Las Vegas" eight years in a row by the Las Vegas Review-Journal, cracked jokes about families, relationships, men, women, Las Vegas, shopping, cooking and just about everything else she encounters in her day-to-day life.
Her material might have bordered on clich if it were not for her natural, earnest delivery and occasional surprising observations. She directed her jokes mostly at the 40-and-over crowd, who share many of her experiences of marriage, raising a family and growing older; but as a younger audience member I found plenty to relate to as well, especially her material on relationships, fashion and the outrageous Las Vegas culture.
Article Photos
Vegas favorite makes the MACC LOL by finding the humor in almost everything
Rudner's warm, easygoing style was perfect for the intimate McCoy Studio Theater. Watching her perform felt a bit like chatting with a particularly witty and talkative friend.
When I interviewed her a few weeks ago, she told me, "I prefer, just like I'm talking to you, to talk like that. I like people to get images in their heads and to put them together themselves. I don't like to tell people what to think. I like it when I can use as few words as I can to create a very, very dramatic image. And that makes people laugh."
Rudner's casual style and down-to-earth material made her show light and fun. Free of commentary on politics, war, corruption, climate change, health care, or anything else audiences would hear about on the news when they got home, Rudner's act was pure entertainment. I left the theater in a great mood, still laughing at her jokes.
Allowing her listeners to stop thinking and just enjoy themselves is Rudner's main goal. "People who come to a theater really want to be entertained," she said. "It's not easy to come to a theater - you have to find a babysitter, you have to find a parking space, you have to get in traffic - it's hard!" For that reason, she explained, "I don't really like to talk about politics. I leave it out of my act, because I don't want to be there to lecture people on what they should think. I like people to have a good time and to forget their troubles."
Next time you visit Las Vegas, catch Rita Rudner at her own theater at Harrah's. Or if you like your laughs closer to home, don't miss the next comedian in the "LOL@ MACC" lineup, Melinda Hill, who takes the McCoy Studio Theater stage on Jan.13.
Coming up
"Little Women - The Musical": Six generations have loved the book. Now Louisa May Alcott's "Little Women" comes to Maui as a delightful musical. Another bold venture from Hana Arts, "Little Women - The Musical" is living evidence that small communities can do great things. With a string of hits, most recently a sold-out run of "Guys and Dolls," this midwinter show and its 20 songs add to a solid reputation for excellence. Directed by Joyce Mitchell-Mynar and Linda Enriquez Meyer, the show stars Kelly Kristofferson, Joyce Mitchell-Mynar, Linda Enriquez Meyer, Jerry Eiting, Barbara Sedano and Christopher Radko.
* "Little Women - The Musical" takes the stage at 7 p.m. Tuesday, Wednesday and Dec. 30 at the Wananalua Church in Hana. Tickets are $15, $25, $50 and $5 for children under 12. Call 248-7569 for tickets.
"The Fantasticks": In the new year, ProArts will resume its run of "The Fantasticks," the longest-running musical in history. This wonderful parable tells of a young man and the girl next door, their scheming parents, romance, disillusionment and the realities of love. Directed by Doug Kendrick, the show features some of Maui's most talented performers, including Robert Wills, Leighanna Locke and Tom Althouse. With book and lyrics by Tom Jones and music by Harvey Schmidt, "The Fantasticks" includes such great tunes as "Try to Remember," "Soon It's Gonna Rain," "I Can See It, " and "They Were You."
* "The Fantasticks" performs weekends at 7:30 p.m. Fridays and Saturdays and 2 p.m. Sundays, Jan. 7 through 16 at the ProArts Playhouse in Kihei. Tickets are $25 for adults and $20 for kids 12 and under. Call 463-6520 for tickets.
LOL@MACC with Melinda Hill: Laugh out loud with Melinda Hill, a Los Angeles-based comedian, actress and writer who has performed stand-up all over the world at theaters, clubs, colleges and for U.S. troops in Guam, Singapore, Hawaii, the Marshall Islands and beyond. LA Weekly describes her comedy as "bubbly, adorable, outlandish, funny" and Buzzine Magazine claims she "puts the fun back in funny and the smart back in smarty-pants." Hill will perform her new work, "Marriage Material," an interactive, hilarious dating show.
* Melinda Hill performs at 7:30 p.m. Thursday Jan. 13 at the MACC's McCoy Studio Theater. Tickets are $25 for standard and $45 for VIP with post-show meet, plus applicable fees. Tickets are available at the MACC box office, 242-7469 or www.mauiarts.org.
"The Great Kaua'i Train Robbery": "The Great Kaua'i Train Robbery" is a historical drama with a strong emotional core and a nostalgic, bittersweet tone. Set on Kauai in the early 20th century, this play was inspired by a series of real events: a dramatic train robbery (the only one in Hawaii's history), investigation of the crime and the ensuing trial. The main character is a man named Hali, whose devotion to his loved ones and deep sense of social responsibility drives the play and ultimately makes him a suspect in the case. Kumu Kahua Theatre commissioned Lee Cataluna as playwright.
* "The Great Kaua'i Train Robbery" shows at 7:30 p.m. Jan. 14 and 15 at the MACC's McCoy Studio Theater. Tickets are $22 plus applicable fees, available as above.


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I Luoghi Della Battaglia
Paper 52 pp.
Release Date:
Online discount: 25%
$18.99 $14.24
This Italian translation of The Canadian Battlefields in Italy: Ortona and the Liri Valley features specialized three-dimensional maps that show the terrain and towns as they have never been seen before. This book is an excellent companion for an Italian vacation.
Published by the Laurier Centre for Military, Strategic and Disarmament Studies and distributed by Wilfrid Laurier University Press.
Eric McGeer holds a PhD from the Université de Montréal and teaches at St. Clement's School in Toronto. He is the author of Words of Valediction and Remembrance: Canadian Epitaphs of the Second World War and several books on warfare and law in ancient Byzantium.
Matt Symes is a PhD Student at Wilfrid Laurier University where he is studying sport and leisure in the Second World War.
Related interest
By the same author
Canada and the Second World War: Essays in Honour of Terry Copp, Geoffrey Hayes, Mike Bechthold, and Matt Symes, editors
Canadian Battlefields of the First World War: A Visitor's Guide, Terry Copp, Mark Humphries, Nick Lachance, Caitlin McWilliams, and Matt Symes
The Canadian Battlefields in Italy: Ortona and the Liri Valley, Eric McGeer and Matt Symes
The Canadian Battlefields in Italy: The Gothic Line and the Battle of the Rivers, Eric McGeer and Matt Symes
1812: A Guide to the War and its Legacy, Terry Copp, Matt Symes, Caitlin McWilliams, Nick Lachance, Geoff Keelan, and Jeffrey Mott
The Great War: From Memory to History, Kellen Kurschinski, Steve Marti, Alicia Robinet, Matt Symes, and Jonathan F. Vance, editors


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Get the training to become an administrative professional, and prepare to become a certified Microsoft Office 2010 Master at the same time. The online Microsoft Office 2010 Master training will teach you how to use the entire suite of programs: Word, Excel, Outlook, and PowerPoint, while preparing you for certification.
Upon successful completion of this course, you'll be able to:


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Entertainment Photos
Slidin' around at DFW Curling Club open house
Photo: Michael Ainsworth/Staff Photographer
Mike and Sheryl Helm of Keller watch as they get instruction from Nick Myers during the DFW Curling Club Open House at the Dr Pepper Star Center in Farmers Branch on September 18, 2013. They will also have an open house on Sunday, Sept 22nd from 5 to 7 pm.
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Saginaw Township goaltender Devin Williams is expected to sign a contract to play for the Erie Otters of the Ontario Hockey League Thursday and suit up for the team for the first time Friday, according to his father, Clarence Williams.
Devin Williams, 15, would become the first area player to sign an OHL contract since Brad Walch of Thomas Township signed one with the Saginaw Spirit in 2008.
The Otters declined to confirm the impending signing, saying they would announce it with a press release when it becomes official.
The Otters drafted Williams in the fifth round, 95th overall, in the Ontario Hockey League's Priority Selection in May. He attended the team's training camp in late August, and made it to their final round of cuts before being reassigned in early September.
The Otters played the early portion of the season with three goaltenders, before trading Chris Festarini to the Niagara IceDogs Wednesday morning. That left two goaltenders on their active roster: Ramis Sadikov and Tyson Teichmann.
Williams traveled to Erie the next day, Clarence Williams said, after the two sides worked out the details of his education package. Clarence Williams said the team intends to dress his son for their Friday night game home game against Plymouth.
The Otters intend to use Devin Williams as a floating affiliate this season, Clarence Williams said. Floating affiliates can appear in up to 10 games during the OHL regular season. The team has said one of those games could be when the Otters play against the Spirit Dec. 11 at The Dow Event Center.
Williams will spend the rest of his season with the Metro Jets, a Tier III Junior A team based in Waterford. In eight games this season, Williams has a 3.34 goals against average and a .911 save percentage with the Metro Jets. His goalie coach there is Randy Wilson, the former Spirit goaltender coach.
Before joining the Metro Jets, Williams earned a gold medal playing for Team USA in the Five Nations tournament, held in Ann Arbor in August.


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Dictionary of Australian and New Guinean Mammals
200 pages, 196 x 126 mm
CSIRO Publishing
Dictionary of Australian and New Guinean Mammals is the first unified guide to the mammals of both Australia and New Guinea. Based on Ronald Strahan's first dictionary of Australian mammals, published in 1981, it includes all species, both native and introduced. For each species and genus, it provides a clear guide to pronunciation, the derivation and significance of the component parts of the name, and the citation that identifies its earliest valid description.
This unique work includes biographical notes on fifty-one zoologists who, over the past three centuries, have named Australian and New Guinean mammals.
The book also includes an account of the principles and practices of zoological nomenclature, together with a comprehensive bibliography and an index of common names.
Dictionary of Australian and New Guinean Mammals is an invaluable reference for mammal researchers and students, as well as anyone interested in natural history.
"This book is an essential resource for any one interested in the mammals of the region, not just scientists and students working in mammalogy, but also the lay person with an interest in the mammals. This book will prove itself to be a timeless and indispensable reference book, and will rarely sit idle on the bookshelf for very long."
Karl Vernes and Stephen Jackson, Australian Mammalogy Reviews, 2008
"The scope of this fascinating dictionary is not primarily biological. Rather, it has been written for people, biologists and laymen alike. If you are one of those, you now know where to turn to - you will certainly not regret it!"
Frank E. Zachos, Mammalian Biology, November 2007


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Get Rid of Poor Soil - Once and For All!
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"I had to write to tell you how well SoilSyrup works. I had a Jasmine plant that was looking very sickly, with yellowing leaves and it would hardly ever bloom. Well, I started adding SoilSyrup to my weekly waterings and in just a few weeks it was looking green and healthy. Now it has dozens of blooms and just smells wonderful! Thanks."
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"I just had to let you know that your Soil Syrup is a great product. As an Ag Engineer I have always known what Humic Acid was, but I had never used it. That being said, I had to re-sod part of my property three weeks ago. I sprayed Soil Syrup on the prepared soil before I put down 100 sq ft of sod in the pack yard. I put another 50 sq ft of sod in the front yard with not treatment. You aught to see the back yard portion. I had to cut it yesterday. It has taken so well that I can hardly see the demarcations between the sod pieces. This stuff is great!"
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In hydroponics and indoor gardening systems, SoilSyrup will increase the effectiveness of nutrient uptake by plants, meaning you can use less of those expensive nutrient solutions. Start growing more effectively with SoilSyrup today!


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Thursday, April 26, 2012
Culinary Specialist Michelle Roberts Blends Passion and Skill to Share the Seasons Best Recipes, Tips, and Techniques
Meet Taste of Home Culinary Specialist, Michelle Red Roberts. Michelle conducts Cooking School shows across the country. Her love of traveling to experience the flavors of different cities combined with her enthusiasm for cooking allows her to share her culinary passion with people just like you!
When did her love for the kitchen start? Michelle grew up helping her grandmother in the kitchen and knew at an early age that she wanted a career in food. And as an accomplished singer, she can combine her two loves of being on stage and cooking.
The passion continued from there, Michelle earned an Associate of Applied Science degree from Copiah-Lincoln Community College in Wesson, Mississippi and a Bachelor of Science degree in Culinary Arts from Mississippi University for Women in Columbus, Mississippi.
When asked what her favorite part of the Cooking School experience is, Michelle replied, I love being on stage, entertaining, and sharing my love of cooking!
Michelle resides in Calera, Alabama, with her two cats; Simon and Madeline. One of her favorite activities includes spending time at home watching good movies.
Michelle is looking forward to coming to the Lowcountry. Were going to have a lot of fun at this event! Trust me, you dont want to miss it! says Red.
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BT Global Services' Yury Rozenman discusses the changing landscape of pharma services.
By Kevin Davies
November 29, 2011 | Why would a chemist who has worked for some of the leading bio-IT companies of the 15-20 years, including Celera Genomics, Applied Biosystems, D.E. Shaw Ventures and IBM, find himself working for the company formerly known as British Telecom?
"I was just as surprised," said Yury Rozenman, who is BT Global Services' head of marketing strategy and solution development for life sciences (see, "A Long Road to BT"). "Why would BT Global Services be interested in developing solutions for pharma?"
Why, indeed. At the time, he explained, BT began to realize that, even as companies such as IBM present solutions for data integration and connectivity, "the missing element was connecting people, making sure they could make sense of the information and bring greater value to pharma companies."
One of the most exciting examples of enterprise communications services offered by BT Global Services is the management of all patient records for the UK's National Health Service (NHS), including solutions such as e-prescriptions and pharmacovigilance. "We knew we could take those assets and apply them globally to the health care and life sciences ecosystem—pharma, biotech, CROs, and potentially even payors and providers," says Rozenman.
BT's bread and butter is in what Rozenman calls "transformational deals," where pharma companies acknowledge that tasks such as managing a global network is not their core expertise. BT wins if it can demonstrate it can bring better return on investment and implement useful services on top of the network—and do it all, of course, in accordance with tight regulatory requirements (e.g. GxP, FDA 21 CFR Part 11, etc).
In 2005, BT signed a large US pharma to manage its enterprise communications services, as well as Swiss and Japanese companies. "But it's always difficult to get public release," Rozenman sighs, unable to divulge the client's name.
"Most of our clients are multinational corporations," says Rozenman. "We connect people around the world with data/voice applications. For the most part we try to focus on companies that need global reach to support their internal and external operations. We work with the top 25-30 pharma companies, as well as CROs and medium-sized biotechs."
A large percentage of BT's core services fall around strategic outsourcing—largely LAN/WAN security and unified communications. "That's how we start usually. That's our way in," says Rozenman. "We need to prove we can do that well. We work with HP, Dell, EDS, IBM, it depends—the pharma company will carve up their IT outsourcing operations into towers, so servers/storage might go to IBM, communications to BT, laptops to HP, [consulting] to Accenture… We have to work across all the vendors."
More Than Core
In recent years, however, BT has been hearing from customers that supplying core services isn't necessarily sufficient. Paraphrasing, Rozenman hears things like: "You have expertise, but this is not enough. For us to continue to work with BT, you need to provide solutions not just for cost containment, but start creating more value, a balance between cost and payment."
"We work with pharma to identify what they want us to support. That usually differentiates us in terms of price and capabilities from other telecoms," says Rozenman. Those needs increasingly include the ability to handle large data volumes and ensure they can travel around the world securely. And there are specific areas around R&D collaboration, chronic disease management, patient compliance, and the supply chain.
One of those projects, with Liverpool City Council, is a "home of the future" pilot to study the management of chronic diseases for the elderly population. This pilot focused on supporting patients in their home environment, using sensors and a self-learning system to learn about the patient's behavior and detect signs of trouble such as a fall in the home, lack of movement, etc.
On the supply chain side, Rozenman's team is helping track, trace and authenticate drug supplies, in some cases down to a specific bottle, in an effort to combat rampant counterfeiting of approved drugs, identifying "grey markets" and potentially initiating drug recalls.
Support of patient compliance, persistence and adherence to dosing during clinical trials (and approved drugs) is another key area for BT solution development. Even highly successful and effective drugs such as Gleevec show non-compliance rates around 30 percent. "If there is a drop in compliance, the pharma sponsor will allocate more drug to drive compliance. We need an intervention mechanism," says Rozenman. "It's not about reminders. It's about the ability to connect the patient to the doctor, providing the necessary support mechanism, and in cases of adverse effects, providing patient training and options to help patients alleviate symptoms," says Rozenman.
Cloud Sourcing
BT has great interest in cloud computing applications, recently running a "hothouse" event in London to bring stakeholders together. "There is significant interest from pharma around private clouds or hybrid clouds, not public," says Rozenman. "Having said that, we're running a very large cloud service for financial firms, called Radianz. It connects trading floor operations, content services, and transactional operations. We're in the process of developing something similar for pharma."
"We have not launched the platform in the full sense yet," says Rozenman, but the company has run pilots for a UK pharma and seen some ideas incorporated into the Pistoia Alliance. It is also working with the MIT Media Lab and the BioTeam, as well as a large ISV "to become a foundational partner in the ecosystem… running apps in the BT Cloud environment."
The needs of financial services and life sciences are very different, however. The key attribute for financial firms is very low latency. "It's not necessarily compute intensive, but very network centric. They have to move data, provide security, and encryption."
Pharma, by contrast, typically doesn't run a single app but data pipelines, and thus requires many data sources around the world to be connected. "It's not Windows but Linux or UNIX, so you need multiple platforms. And if you're running a pipeline, you are running different programs. If it is clinical data, you may not be able to move data due to EU regulations (privacy protection laws). Everything we can do in the financial cloud we'll take to apply [to pharma]."
Rozenman says BT Global Services hopes to help ISVs deliver on demand services. By 2014, pharma says it wants to externalize their R&D or clinical services. "Within six months, we'll have some proof of concepts completed and additional requirements to launch Phase 2. We want an app store, but we're discussing with Schrodinger, Eagle Genomics and others… how to increase the use of in silico biology and chemistry through cloud-based services."
BT is in the business of "business enabling," says Rozenman, and prefers to build solutions around the clients' needs rather than create its own software. "We need to calculate: is it cheaper to move data to the app or stage the app in a virtual data center around the world? Depending on the requirement, data size, and resources, we can make decision automatically whether we stage or move. There's enough intelligence in our cloud that we can stage very quickly."
BT Global Services has its own security group that develops solutions for pharma and other industries. "We look at regulations, how infrastructure needs to be rolled out depending on the vertical. HIPPA rules to anonymize data if you need to."
"Perception is important," says Rozenman. "We can enforce rules, privatize data and IP, or share with single clients. We can create rules to ensure that is in place. We'll also do ethical hacking if they want us… to try to break the security."
While clinical endpoints are classical data points, Rozenman says BT's system is capable of taking genotype/phenotype information. "As we move forward in diagnostics, with complete genomes, you can reliably use the information to pick the right people for clinical trials, and quickly do genotyping, identify the right cohorts… Instead of 3,000 patients, you can get away with smaller, more focused clinical trials. We'd like to use our R&D platform to support early research informatics and simulated clinical trials. We're in discussions in software around simulating clinical trials, to structure protocols and run more efficient trials. This is a very interesting area for our health care practice." •
A Long Road to BT
Yury Rozenman has spent most of his career in the life sciences and pharma since graduating from the University of Illinois 25 years ago. A chemist by training, he worked for GD Searle in Chicago (now part of Pfizer), running analytical development before switching to licensing and acquisitions, searching for new compounds to bring into the pipeline.
In 1993, he joined Applied Biosystems, helping develop DNA sequencing and genotyping technologies. When ABI launched a sister company, Celera Genomics, in 1998, Rozenman worked for Craig Venter and colleagues in field operations, interfacing with pharma companies seeking access to gene databases, advising on IT infrastructure.
Rozenman later went to work for D.E. Shaw Ventures, which started among others Amazon, Schrodinger, and an online service called Juno (which merged with NetZero in 2001) for computational analysis. Following stints with Platform Computing and IBM, where he worked with Carol Kovac, again focusing on industry solutions for pharma, he joined BT Global Services. K.D.
This article also appeared in the November-December 2011 issue of Bio-IT World magazine. Subscribe today!
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I still think you all are underplaying the role of the substantial amounts of fermented foods that Pollan consumes in the "health" of his gut biome.
I am sure the fiber he gets keeps the bacteria in his gut fed, but without the fermented foods he doesn't even START by having that much bacteria to keep healthy in the first place. I'm betting it's the COMBO of the fermented food and the fiber together that give him the large gut population.
This is why I was annoyed that he didn't even mention fermented food, probiotics, and his copious consumption of both within the article.


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HOME MLB Los Angeles Angels of Anaheim Gear Los Angeles Angels of Anaheim Ladies Los Angeles Angels of Anaheim Ladies Polos (5 items) Product ID: 1710404
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- Material: 100% Cotton
- Tagless collar
- Ribbed collar and sleeve cuffs
- Side slits at hem with contrast taping
- Embroidered team logo on left chest
- Placket with 5 buttons
- Short sleeve
- Officially licensed
- Imported
- Brand: Antigua
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BOX -- E. Wayne-New Bern
By Andrew Stevens
Published in Sports on October 5, 2013 11:30 PM
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Other Local Sports
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- BOX -- N. Duplin-Lakewood
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The man who was shot in West Ashley on Wednesday night has a violent criminal record, and police list the shooting as an aggravated assault.
The incident report from Charleston police identifies the man who was shot as Troy Marion Wright, 32, of Burger Street. He was shot in the hip while riding his bicycle near Davidson Avenue and East Street about 8:40 p.m. No suspect has been identified.
Wright was listed in The Post and Couriers Lowcountrys Most Wanted in October 2005. He was accused of riding up to a car in his neighborhood on his bicycle and firing at least four shots into the car. He was arrested in December and spent nearly a year in jail on a charge of assault of a high and aggravated nature.
Wright also spent 30 days in jail in 2008 for simple assault and 90 days in jail in 2011 for assault and battery of a high and aggravated nature.
A charge of distributing crack cocaine was dropped in 2011 after the buyer said police arrested the wrong man.
Reach Dave Munday at 937-5553 or twitter.com/dmunday.


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The Pals of Our Time
If you thought of PayPal as a registered trademark of the US, think again. Many moons prior to the advent of the first digital transaction, it has been widely available in every nook and corner of our vast nation. Beating the dog and the diamond, it is the best friend upon jumping a red light. The savior of last resort to fix a water-less tap and power-less bulb. The 'stamp of god' on every birth (and death) certificate. Yes, pals are paid at every juncture – to do the things they shouldn't do, and to not do things they should.
Pay-pals continued jumping (with joy) higher hurdles until they hit the creaking ceiling of the Commonwealth games (read shames) stadium. An ensuing revolution in the small park of Jantar Mantar marked the second-innings for the new pal on the block - The Lok-Pal. Now don't get me wrong here, I am eternally thankful to Anna and Co for bringing to center-stage our long-standing toxic affair with the Pay-pals. For what it's worth, it's my sincere endeavor to seek answer to the LakhCrore-Rupee question (literally) – Does the end justify the means - means being Coercive-Democracy.
Fasting has never been my virtue - I am munching as I write. So, I have great admiration for a man who can skip a meal for a cause. Also, a gentleman with a stick in a hand, book in another, yelled enough to make me remember to this day - Gandhi's fast was the heaviest weight on the knob which flushed out our Victorian overlords. That said, it makes intuitive sense to view Anna's fast with rose-colored glasses. Wait a minute though! Did the Brits held free-n-fair elections to let us vote amongst British, French and Dutch rule? The answer to this seemingly-foolish question reveals the cracks in Anna's "Second freedom struggle" logic - The present power of the vote leaves little room for the historic power of the fast.
The informative/marketing value of a fast, however, remains undeniably relevant thru the ages - especially ours where (sadly) only Sex and Balan sell (SRK is passé). There exists, however, a thin line between marketing and blackmailing. Balan, dancing atop a hoarding, to promote women empowerment in 'The Dirty picture', is good marketing. Balan, threatening to jump off if audiences see sleaze instead, is blackmail. Anna, fasting at Jantar Mantar to galvanize and unite the masses against graft, is welcome marketing I stand topi-on-my-head by. Anna, threatening to fast unto death if his version of Jan Lokpal is not adopted in comma and period is, though innocuous and well-meaning, still blackmail.
Also, almost in line with Indian Idol voting, are claims by IAC of 2.5 crore missed calls in support of the Jan Lokpal bill. An elementary clause-by-clause Q&A with callers, though, will reveal the blissful ignorance - most of the calls are only in disdain of the polity and graft, oblivious to the penning of the bill. The ones who queue up to stain their forefingers every five years are ignorant of the parliament's version too, I acknowledge. The parliament, however, stands firm on the underpinnings of the gigantic five-yearly-franchise mela of 1.2 billion - No amount of Facebook 'likes' and missed calls can supplant the click on the EVM.
Here, I want to make a categorical distinction between the significance of the EVM and shoddiness of the logos adorning it. The 'Palm', more than often, symbolizes a slap to the common man; The 'Lotus', its muddy surroundings; The 'Elephant' tramples the very people who feed it. Team Anna and their 'celebrity' guests do point to the quality of our polity, but with counter-productive (often political and party-specific) vitriol. The need of the hour is to stir and shake the nation to the power of their vote and representation. The nation needs constructive criticism and political awareness, not entertainment with caricatures. Polity needs to be brushed with good-old Dettol to do away with germs, not dipped in acid and melted away.
Recent interviews by Team Anna reflect introspection on their setbacks. The chants of 'Sare Neta Chor Hain' seem to have fainted, the epic display of 'Clash of the Egos' blurred. A more positive approach to political vigil and reform, inculcation and encouragement of youth into the political process, a step away from electoral-bashing, are welcome moves. Also, let's not put nine ladies together to get a baby in a month - There exist as many blacks as whites on Lokpal, the elusive hue of gray needs to be churned through a non-stop nation-wide dialog, over time. Our democratic tectonic plates, three thousand Km wide, are heavy and hard to move - Why hold a gun at the heads of a few to kick with knee-jerks when 1.2 billion can be united to push in unison?
Indian Railways is perhaps a fitting microcosm of our democracy. Both criss-cross the metro and the hinterland alike. The fans are generally mere noise-making machines and the shining neon bulbs frequently flick out. The din is disproportionate to the pace and both leave a lot of shit on the way. There are perpetual delays, and occasional derailments. Swindlers often get on the bogies. So do the hefty and sons, who usurp the upper berths. As we make five-yearly stops, our best pal perhaps is the awake passenger next seat and a formidable ticket-collector at the door.


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The helpless inability, paradoxically highly prevalent amongst the lowest paid and most debt-ridden, to stop buying shit, resulting in further indebtedness and misery.
'Pass me the phone Kayleigh- I've got to have that Tanzanium-studded eternity bracelet NOW!'
'On my life Keleese- you have just got buyorrhea!'
'On my life Keleese- you have just got buyorrhea!'
von The Real Henry Higgins 22. November 2009
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yesterday while i was on the youtube app, i paused the video and came back to my xbox being frozen. this has happened before so i restarted my console. upon doing this the light went from green to red. i am familiar with the red ring of death on the older consoles because i have had that quite a few times.(this is my 4th xbox). this was my 1st assumtion. after reading online i see that this has happened to alot of people. this was a launch 360s that i pre-ordered. i wonder if its just getting old. some say the light means the xbox isnt getting enough ventilation. so maybe a fan would fix it? i was going to find out but when i turned on my xbox today the light on the power brick turned red.i unplugged it until the light turned off and tried again and it works but i dont want to run my xbox right now. i am afraid if i run my xbox it will damage it further. what can i do? i have a launch 360s so i can assume my warranty is expired.
For the red dot on the console check this link, the topic red dot on the console support.xbox.com/.../console if the steps to solve the problem the console is likely in need of a repair...
Hi there, sorry to hear of your problem.
You can take a look here, and try some of the solutions to some power issues
Let us know of your findings/results
thank you for the link but what about the red light on the power button?
If the Xbox still shows green rings it may be a defect in your console's lighting.
If the steps fail to solve the problem, is what I mean to say
To request a repair, you can use this link support.xbox.com/.../repair-process
So i turned on my xbox and it had the red dot. I unplugged it and restart but it still has the red dot but fully functional. What's wrong?
Hey there Killa! If you are seeing the Red Dot on your console, I would recommend following the suggestions above and see about getting a console repair. Please let us know if you have any questions regarding that process, thanks!
Xbox Community Ambassadors TeamJoin the community!
I have xbox 360 slim just 11 months old one day in sunday i turn on i see red dot. one day later its workd monday and tuesday(bad langue) then now its red again. but in tv not showing E error.
Hey there Davis! Please check out the verified link in this thread and follow all the steps there. Thanks!
Maybe wire is not good like main i put in stronger the i push it down up and then i find were the problem
Hello Davis Peskovs12,
Have you clicked on the link that WPAK posted in the thread above? It will be the one with the green "Verified Answer" in the top of the post where the date and time of the post are.
Do you have an idea to improve Xbox for everyone? Share it with us at Xbox Feedback!
How to use the Forums!
NO i found out myself. Mybe in your xbobx is somthing breaked or not I dont now. Mybe in the wire is somthing wrong ( My langue is bad).
Hey guys! Since this thread is originally from June, I'm going to go ahead and lock it so we don't keep bumping the OP. For any further help make sure to create your own thread in this forum so we can help you out individually. :)
How to use the forums


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Hi! My name is Cheddar
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My favorite tricks and treats are: nope and his kitten formula..
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My pet peeves: He hates having his tail pulled he'l bite, thats why he hates little kids!
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From Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, and University of Washington, Seattle, Washington, and Vanderbilt University and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
Results were presented in part at the American Society of Hematology Annual Meeting, New Orleans, Louisiana, 5–8 December 2009.
Acknowledgment: The authors thank William O'Brien for assistance in linking the analytic data sets.
Grant Support: By the American Society for Blood and Marrow Transplantation, the Leukemia and Lymphoma Society, and the Seattle Children's Research Institute.
Potential Conflicts of Interest: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-2448.
Reproducible Research Statement:Study protocol: Not applicable. Statistical code: Available from Dr. Chow (e-mail, email@example.com). Data set: Not available.
Requests for Single Reprints: Eric J. Chow, MD, MPH, Fred Hutchinson Cancer Research Center, PO Box 19024, M4-C308, Seattle, WA 98109; e-mail, email@example.com.
Current Author Addresses: Drs. Chow, Mueller, Baker, Flowers, Martin, and Lee and Ms. Cushing-Haugen: Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109.
Dr. Friedman: Vanderbilt Ingram Cancer Center, 2525 West End Avenue, Nashville, TN 37215.
Author Contributions: Conception and design: E.J. Chow, B.A. Mueller, D.L. Friedman.
Analysis and interpretation of the data: E.J. Chow, B.A. Mueller, K.S. Baker, K.L. Cushing-Haugen, P.J. Martin, D.L. Friedman, S.J. Lee.
Drafting of the article: E.J. Chow.
Critical revision of the article for important intellectual content: E.J. Chow, B.A. Mueller, K.S. Baker, K.L. Cushing-Haugen, M.E.D. Flowers, P.J. Martin, D.L. Friedman, S.J. Lee.
Final approval of the article: E.J. Chow, B.A. Mueller, K.S. Baker, K.L. Cushing-Haugen, M.E.D. Flowers, P.J. Martin, D.L. Friedman, S.J. Lee.
Provision of study materials or patients: B.A. Mueller, M.E.D. Flowers, P.J. Martin.
Statistical expertise: E.J. Chow.
Obtaining of funding: E.J. Chow, B.A. Mueller, P.J. Martin, D.L. Friedman.
Administrative, technical, or logistic support: B.A. Mueller, M.E.D. Flowers, P.J. Martin.
Collection and assembly of data: E.J. Chow, B.A. Mueller, P.J. Martin, D.L. Friedman.
Background: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat multiple malignant and nonmalignant conditions. The risk for cardiovascular disease after the procedure has not been well-described.
Objective: To compare rates and hazards of cardiovascular-related hospitalization and death among persons who were still alive at least 2 years after HSCT with those in a population-based sample.
Design: Retrospective cohort study.
Setting: Comprehensive cancer center.
Patients: 1491 patients who had survived 2 years or longer after HSCT received between 1985 and 2006, and frequency-matched persons who were randomly selected from drivers' license files in the state of Washington.
Measurements: Cardiovascular hospitalizations and death, as determined from statewide hospital discharge records and death registries in Washington.
Results: Compared with the general population, transplant recipients experienced increased cardiovascular death (adjusted incidence rate difference, 3.6 per 1000 person-years [95% CI, 1.7 to 5.5]). Recipients also had an increased cumulative incidence of ischemic heart disease, cardiomyopathy or heart failure, stroke, vascular diseases, and rhythm disorders and an increased incidence of related conditions that predispose toward more serious cardiovascular disease (hypertension, renal disease, dyslipidemia, and diabetes). No consistent differences in hazards were observed after total-body irradiation or receipt of an allogeneic versus an autologous graft, aside from an increased rate of hypertension among recipients of allogeneic grafts. Disease relapse after transplantation was associated with an increased hazard of cardiovascular death (hazard ratio, 2.3 [CI, 1.1 to 4.8]).
Limitation: All patients received HSCT at a single institution, and no information was available on pretransplantation treatment and lifestyle factors that may influence risk for cardiovascular disease.
Conclusion: Increased rates of cardiovascular disease should be taken into account when caring for patients who have received HSCT. Future efforts should be directed toward improved screening and controlling of factors that predispose toward cardiovascular disease.
Primary Funding Source: The American Society for Blood and Marrow Transplantation, the Leukemia and Lymphoma Society, and the Seattle Children's Research Institute.
Data are shown for 1096 HSCT recipients who were matched to 4352 persons in the general population. The log-rank P value was <0.01 for all outcomes. Comp = comparison group; HSCT = hematopoietic stem cell transplant.
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The practice and current progression in hematopoietic stem-cell transplantationand mesenchymal stem-cell sources have been described in recent literature.The concept of BM origin in certain autoimmune diseases and mobilization of marrow cells by GCSF and possibilities of disease exacerbation , added to the facilities considering ASC ( adipous ) use in vascular disease models or peripheral blood precursors , has been considered in recent guidelines , pros and cons in HSCT. The rfrequency of complications in MS , for example , has been added to death rate between 5 % and 10 % . A related condition is the role of EPC mobilizated in acute cerebrovascular or cardiovascular events. The different subpopulations of EPC showed endothelial markers ( UEA-1 lectin , KDR , vWF ) , related to acute markers in such samples descriptives. Thus , relation between progressio MSC and these markers would be clinical progression pathways in this area.
Ref. Acute EPCs mobilization with greater endothelial differentiation in subacute phase of ischemic stroke. SEN 2008
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Shelby County Sheriff's Office Uses Stun-Cuff to Keep Inmates Compliant
Shelby County's most violent inmates are now being kept in line with the use of a newly acquired device for compliance: the Stun-Cuff. Before any inmate gets assigned a shock device, they get a full demonstration. Inmates aren't the only ones briefed; DRT members at the jail get 8 hours of training and they have to experience the Stun-Cuff first hand.


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What you drop on your head by smoking a great deal of high quality marijuana.
I think all the radiation from that chron-bomb tweaked my skull!
Trogdor가 작성 2003년 11월 13일 (목)
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Can you define these popular missing words?
some bomb ass chronic that gets you baked as shit
man i just smoked a fatty of some chronbomb
ballhousen가 작성 2007년 11월 12일 (월)


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From Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, and Massachusetts General Hospital, Boston, Massachusetts.
Acknowledgments: The authors thank the study participants for their continuing cooperation and Sharon Curhan, MD, Elaine Coughlan-Havas, Albert Liu, Gary Chase, Karen Corsano, Barbara Egan, Lori Ward, and Stefanie Parker.
Grant Support: By research grants DK45362, CA40356, and CA55075 from the National Institutes of Health.
Requests for Reprints: Gary C. Curhan, MD, ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115.
Current Author Addresses: Drs. Curhan and Willett: Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115.
Copyright ©2004 by the American College of Physicians
Background: Calcium intake is believed to play an important role in the formation of kidney stones, but data on the risk factors for stone formation in women are limited.
Objective: To examine the association between intake of dietary and supplemental calcium and the risk for kidney stones in women.
Design: Prospective cohort study with 12-year follow-up.
Setting: Several U.S. states.
Participants: 91 731 women participating in the Nurses' Health Study I who were 34 to 59 years of age in 1980 and had no history of kidney stones.
Measurements: Self-administered food-frequency questionnaires were used to assess diet in 1980, 1984, 1986, and 1990. The main outcome measure was incident symptomatic kidney stones.
Results: During 903 849 person-years of follow-up, 864 cases of kidney stones were documented. After adjustment for potential risk factors, intake of dietary calcium was inversely associated with risk for kidney stones and intake of supplemental calcium was positively associated with risk. The relative risk for stone formation in women in the highest quintile of dietary calcium intake compared with women in the lowest quintile was 0.65 (95% CI, 0.50 to 0.83). The relative risk in women who took supplemental calcium compared with women who did not was 1.20 (CI, 1.02 to 1.41). In 67% of women who took supplemental calcium, the calcium either was not consumed with a meal or was consumed with meals whose oxalate content was probably low. Other dietary factors showed the following relative risks among women in the highest quintile of intake compared with those in the lowest quintile: sucrose, 1.52 (CI, 1.18 to 1.96); sodium, 1.30 (CI, 1.05 to 1.62); fluid, 0.61 (CI, 0.48 to 0.78); and potassium, 0.65 (CI, 0.51 to 0.84).
Conclusions: High intake of dietary calcium appears to decrease risk for symptomatic kidney stones, whereas intake of supplemental calcium may increase risk. Because dietary calcium reduces the absorption of oxalate, the apparently different effects caused by the type of calcium may be associated with the timing of calcium ingestion relative to the amount of oxalate consumed. However, other factors present in dairy products (the major source of dietary calcium) could be responsible for the decreased risk seen with dietary calcium.
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MAYOR NUTTER on Monday encouraged employers to hire 10,000 Philadelphia youth this summer as part of his Summer Jobs Challenge.
Summer jobs and internships "provide young people with valuable work experience, put money in their pockets and teach them the value of a dollar - regardless of whether a dollar is actually worth a dollar today anymore. That'll be a different speech," Nutter said at a news conference.
WorkReady Philadelphia, which is managed by the nonprofit Philadelphia Youth Network, organizes the summer jobs drive. The program served 6,000 city youth last year, but had to turn down 8,000 applicants because of a shortage of positions.


text:
RSPB Conservation Manager, Stuart Benn, is back to tell us about his work with the stunning Slavonian grebe.
Slavonian grebes
The weather has taken a real upturn since the weekend and the Highlands have come to life – ring ouzels piping from corries, divers wailing across lonely lochans and crested tits purring in the old Scots pines. But, for me, the sight and sound of Slavonian grebes chittering softly to each other before pumping up their gorgeous orange-yellow ear tufts to show themselves at their best, eclipses them all.
Slavs are one of those birds, like goldeneye or red-throated divers that occur in a band right round the northern hemisphere and, whilst common in world terms, are restricted as breeders in the UK to small parts of Scotland. And Slavs are more restricted than most – last year there were just 29 pairs on a handful of lochs round Inverness and the recent counts give little room for optimism, plummeting like the FTSE 100 on a bad day. But they are still with us and, by far the best place to see them is at the RSPB's Loch Ruthven reserve, the single best site in Britain. I popped in there early on Saturday – the birds are back and looking absolutely splendid (so much so that even Beyoncé has copied the look!!).
I've been lucky enough to work with Slavs for the past 20 years and much as I love my days with eagles and dotterels, the times I have with the grebes stand out. But, for much of that time, we've been trying to work out why they have such a restricted distribution and quite why they have declined so much. To be honest, the answer has eluded us so far but a new collaboration is giving us hope that we won't be in the dark for much longer.
In early March I spent a few days in Reykjavik talking to Icelandic and Norwegian Slav grebe workers. Interestingly, Slavs in Iceland are increasing rapidly whilst northern Norway is doing the exact opposite and, by pooling our knowledge, we're beginning to get a clearer picture of what might be going on across their range and not just our wee bit of it. And, of course, once you know what the problems are you can start doing something about them.
It's early days yet and we've still a lot of work to do but I'll be giving a talk about what we know about the Slavs and where we're going next at the Scottish Birdfair. Why not come along – it'll be great to see you and there will be loads of other things to do too!
Well I hope you're successful in catching them and that your buddies in Iceland can be helpful as well :)
Give my regards to Sarah!
Hoping to catch more this year but that one is an old photo.
Have you been catching them this year or is that an old photo? I miss seeing the Slavs :( Hope you're all having a great time though! Sarah West


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Volunteers Needed for Progressive Dinner Party
April 28, 2011 - Carla Tracy
Volunteers are being sought for the third annual "Progressive Dinner Party Through Lahaina's Historic Sites," to be held on two evenings, Friday, May 13 and Saturday, May 14 from 5:45 to 10 p.m.
Basically, the Progressive Dinner is a chef-prepared, three-course feast. Attendees are taken on a tour to three different museums or historic sites in old Lahaina. The museums and sites serve as venues for each course served.
"The evening will also include a dinner theater show, live music and a narrated historical tour as you travel by trolley between the sites," says Theo Morrison, executive director of the Lahaina Restoration Foundation, sponsor of the gourmet affair.
Participating Lahaina chefs are Mark Ellman of Mala Ocean Tavern, Sheldon Simeon of Star Noodle, and Ryan Luckey of Pineapple Grill. Each chef is volunteering his time and extensive talents to prepare a unique and elegant dinner for the occasion.
"We are seeking volunteers to assist with set-up, serving food and clean up," says Morrison. "The work is fun and it's a great opportunity to meet like-minded people and get 'behind the scenes' at this exciting event."
Diners may choose either Friday or Saturday evening to attend. Cost of $135 per person includes dinner, beer and wine. Or purchase tickets by May 7 and pay just $250 for a party of two. All proceeds will benefit Lahaina Restoration Foundation, a nonprofit organization that works to restore, maintain and interpret the physical, historical and cultural legacy of Lahaina.
For tickets or to volunteer, call Lahaina Restoration Foundation at (808)-661-3262, Monday to Friday, between 9 a.m. and 5 p.m. Or visit lahainarestoration.org.
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Blog Photos
Sheldon Simeon of Star Noodle and Busaba Yip-Douglas, a docent at Wo Hing Museum.


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After a video emerged showing U.S. Rep. Vance McAllister kissing his married staffer, one state lawmaker and the head of the Louisiana Republican Party are calling for McAllister's resignation.
That state lawmaker pushing for McAllister's resignation is Rep. Robert Johnson, D-Marksville, who ran against and lost in November to McAllister, who ran on a strong family values platform.
"This is an embarrassment for Louisiana. I think he needs to resign, and I don't think he can be effective," said Johnson, who also said he's still "very interested" in McAllister's U.S. 5th District seat.
And now, Roger Villere, head of the Louisiana Republican Party, is joining the growing list of names requesting McAllister's resignation, according to this recent story from state political reporter Lauren McGaughy.
McAllister said he intends to run again in November for what would be his first full congressional term "unless there is an outcry for me not to serve."
Some politicians, pundits and community members are questioning whether McAllister's political career can survive and are already eyeing potential candidates to run against him in November. Read McGaughy's full story with responses from potential candidates here.
Do you think McAllister's political career can survive this incident? Should McAllister resign? Vote in our poll and then tell us your thoughts in the comments below.


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Posts: 756From: NJRegistered: Jan 2004
This exercise got me wondering which astronauts have had the most different "types" of ways they have signed their name over the years?
I was thinking #1 would be Anders because I have seen so many different signatures of his that looked nothing like what I thought was a "typical" Anders autograph. Also, Schmitt came to mind.
Is their another Astronaut that I might not be thinking about?
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Jack Black
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Firework Hazards During DroughtUPDATED 10:52 PM MDT Jul 01, 2014
Light off an illegal firework and you'll get fined.Video Transcript
LIGHT OFF AN ILLEGAL FIREWORK, AND YOU'LL GET FINED. OR AT LEAST, THAT'S THE THEORY. BUT AS KOAT ACTION 7 NEWS REPORTER ANNA VELASQUEZ SHOWS US, IT'S NOT THAT EASY FOR ENFORCEMENT PATROLS TO TRACK DOWN CULPRITS. NO ONE WANTS TO SEE HISTORY REPEAT ITSELF LIKE THIS. IN 2003, FIREWORKS STARTED A BOSQUE FIRE IN ALBUQUERQUE THAT THREATENED HUNDREDS OF HOMES. fireworks THAT'S ONE OF THE REASONS WHY PATROLS FROM THE ALBUQUERQUE FIRE MARSHAL'S OFFICE ARE OUT EVERY FOURTH OF JULY HOLIDAY... RESPONDING TO YOUR CALLS OF ILLEGAL FIREWORK ACTIVITY. during the 4th of july holiday we received over 900 calls last year OFFICIALS SAY IF A FIREWORK SHOOTS MORE THAN 10 FEET INTO THE AIR, IT'S BANNED WITHIN CITY LIMITS. ILLEGAL ONES HAVE A WARNING LABEL LIKE THIS. BUT FIRE MARSHAL SCOTT ESPOSITO ADMITS, IT IS DIFFICULT TO TRACK DOWN THE OFFENDER. we issued 10 citations last year. That's not a lot. That's not a lot ESPOSITO EXPLAINS BY THE TIME PATROLS GET THERE, THE PERSON WHO'S SETTING OFF THE ILLEGAL FIREWORKS MAY BE GONE. AND, SO MANY REPORTS COME IN AT ONCE, FIREFIGHTERS GET BACK LOGGED. SO CONSIDERING THAT CHALLENGE, HE SAYS 10 CITATIONS OUT OF MORE THAN 900 REPORTS... ARENT BAD. we saw them in the act. We arrived, they were lighting fireworks, they still had fireworks that we were able to confiscate and use as evidence PATROLS BEGIN THURSDAY NIGHT, AND OFFICIALS SAY YOUR REPORTS OF ILLEGAL FIREWORK ACTIVITY WILL HELP PREVENT A POTENTIAL FIRE. when we do come, even if we don't catch them people will stop doing the fireworks ANNA VELASQUEZ KOAT ACTION 7 NEWS. IF YOU ARE CAUGHT LIGHTING ILLEGAL FIREWORKS IN THE CITY, IT COULD COST YOU 500-DOLLARS AND OR UP TO 90 DAYS IN JAIL. GO TO KOAT-DOT-COM TO FIND OUT WHAT'S NOT ALLOWED, WE ALSO HAVE A LIST OF FREE FIREWORKS
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