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Author Affiliations: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Dr Schimel is now also with the Center for Excellence in Eye Care, Miami.
Endophthalmitis is a serious, sight-threatening condition resulting in substantial morbidity. With the widespread use of fluoroquinolone antibiotic eyedrops as a prophylactic agent, there is concern regarding increased frequency of fluoroquinolone resistance. We report the evolution of fluoroquinolone resistance among coagulase-negative Staphylococcus endophthalmitis isolates at the Bascom Palmer Eye Institute.
The study was approved by the Institutional Review Board of the University of Miami School of Medicine Medical Sciences Subcommittee for the Protection of Human Subjects. This was a retrospective, noncomparative, consecutive case series. We reviewed the microbiological and medical records of all patients with culture-proven endophthalmitis (positive cultures from the vitreous cavity) caused by coagulase-negative Staphylococcus at the Bascom Palmer Eye Institute between January 1, 1990, and July 1, 2011. Susceptibility testing of the intraocular isolates was performed using an automated system—the VITEK automatic microbial system (Biomérieux, Inc) or the E test (AB Biodisk NA, Inc and Remel Products). Frozen isolates were reconstituted as needed to evaluate sensitivities of earlier cases to newer-generation fluoroquinolones.
During the 21.5 years of the current study, 168 patients were identified as having culture-proven endophthalmitis caused by coagulase-negative Staphylococcus. The increasing resistance rates are shown in the Figure for 1990 to 1994 (n = 29), 1995 to 1999 (n = 23), 2000 to 2004 (n = 26), and 2005 to 2011 (n = 89). The respective resistances (in percentages) of the first 3 periods are the following: ciprofloxacin resistance, 10.3%, 17.4%, and 38.4%; levofloxacin resistance, 0%, 17.0%, and 38.4%; moxifloxacin resistance, 0%, 21.8%, and 26.9%; and gatifloxacin resistance, 0%, 21.8%, and 30.7%. The mean resistance rates for January 1, 2005, through July 1, 2011 (n = 89), were 60.5% for ciprofloxacin, 58.6% for levofloxacin, 57.8% for moxifloxacin, and 60.5% for gatifloxacin (Figure).
Figure. Percentage of fluoroquinolone-resistant coagulase-negative Staphylococcus isolates causing endophthalmitis at the Bascom Palmer Eye Institute during the past 21.5 years. Data are divided by each fluoroquinolone antibiotic.
Despite the dual mechanisms of fluoroquinolones to avoid resistance to coagulase-negative Staphylococcus, the frequency of resistance to these organisms is increasing. Recent evidence shows that repeated exposure of ocular and nasopharyngeal flora to ophthalmic antibiotics, including fluoroquinolones, creates resistant strains.1,2 It has further been shown that resistant strains of coagulase-negative Staphylococcus may be associated with greater ocular inflammation, greater virulence, and increased ocular infection rates compared with susceptible strains.3,4
Fourth-generation fluoroquinolones are significantly more expensive than generic traditional antibiotic eyedrops such as gentamicin sulfate and polymyxin B sulfate/trimethoprim, which have been shown to cover endophthalmitis isolates at least as well.5 Additional recent reports demonstrate that the fourth-generation fluoroquinolones achieve subtherapeutic levels in the aqueous humor and vitreous against the most frequently identified staphylococcal endophthalmitis isolates.6 Given the frequent and increasing resistance, subtherapeutic penetration, and higher cost compared with other antibiotic eyedrops, the widespread perioperative and periprocedural use of fourth-generation fluoroquinolone antibiotic eyedrops should be reevaluated.
Correspondence: Dr Flynn, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL 33136 (email@example.com).
Conflict of Interest Disclosures: None reported.
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Intellectual Property in the International Arena: WIPO Comes to Stanford
November 19, 2010
Stanford Law School
On November 19, 2010, the Stanford Program in Law, Science and Technology will host a one-day conference tobring to the fore current issues relating to intellectual property and the growing importance of intellectual property in today's global technology and knowledge driven economy.
The event, which will feature a delegation of senior officials from the World Intellectual Property Organization – including James Pooley, WIPO's Deputy Director General for Innovation and Technology (WIPO) – and other leading experts from industry and academia, will address the following topics:
- The Proposed Anti-Counterfeiting Trade Agreement (ACTA)
- Copyright in a Networked World – What's next on the agenda?
- International Patent Harmonization
- Future development of the Patent Cooperation Treaty (PCT)
- The Importance of International Industrial Design Protection to US Companies
- The Madrid Protocol: Successful Filing Strategies for US Companies
- ADR for Intellectual Property Disputes
Please join us for this exciting and timely event. Early bird registration is open now. For registration and more information, please click here.

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The Book of Job and the Role of Uncertainty in Religion and Law
Steven Goldberg
Georgetown University - Law Center (Deceased)
May 27, 2009
Georgetown Public Law Research Paper No. 09-11
The Book of Job depicts the radical uncertainty that results when people try to comprehend God. Job has had an extraordinary influence on philosophy and literature, and its message on the limits of human knowledge has even been echoed in the words of great scientists. Surprisingly, however, it has had little influence on the rhetoric or approach of lawyers and judges. The legal profession, which confronts uncertain outcomes daily, has reduced uncertainty to a mundane calculation of odds, while ignoring the more fundamental idea of the unknown because that idea would paralyze legal work.
Number of Pages in PDF File: 9
Keywords: Book of Job, uncertainty, Graham Greene, Werner Heisenberg, Charles Evans Whittaker
Date posted: May 27, 2009 ; Last revised: September 9, 2010
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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
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Any Studio Ghibli fans here? (the Japanese animation movie company)
I've lived in Japan for a while, and studied the language a lot longer, but have never really indulged in Japanese anime or comics (manga). But I just watched "Castle in the Sky" (tenkuu no shiro) a bit ago and really enjoyed it. I've watched "Grave of the Fireflies" (hotaru no haka) years ago as well, which is really good, but a bit heart wrenching (it's about two children, a brother and his younger sister's, plight during World War 2, after losing their family in an air raid). These two films were made in 1986 and 88, respectively (their first 2 films), but they are still producing films. I think I now have to watch them all, I guess I'd might as well continue from the oldest to the present.
Btw, here is the wikipedia (http://en.wikipedia.org/wiki/Studio_Ghibli), all the titles right their for your convenience for bootlegging, or I mean purchasing
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It's the most famous of the animation studios, being Miyazaki's. Grave of the Fireflies is probably the saddest film ever.
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Grave of the Fireflies is real depressing.
When his Setsuko dies
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Yes Sir
High production value and there's always a message in their movies.
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right at you.
Sentiment: Strong Sell
#$%$ deserves it. The company is run by a bunch of anti-American pieces of #$%$. They're about to open a store in my hometown and I intend to denigrate the #$%$holes as frequently as possible. Companies that lick ObaMao's #$%$ deserve to fail...#$%$ is in collusion with the filth that wants to negate my 2d Amendment rights, so eff them.


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LAWRENCE – Obesity, stress and inadequate public transportation dog Mercer County residents and cause them long-term harm, according to a county-wide community health assessment released today by a collaboration of local health organizations.
"Twenty-five percent of Mercer County adults are considered obese," said Lisa Wolff of the consulting group Health Resources in Action during an event at the campus of Educational Testing Service this morning. "That is slightly higher than the regional rate but lower than the national rate."
Health problems are exacerbated by age and poverty, which often limit access to resources such as cars, healthy food and insurance, Wolff said.
Hundreds of hospital executives and community leaders gathered at ETS to hear the results of the assessment, which was sponsored by Greater Mercer Public Health Partnership.
The partnership, comprised of hospitals, municipalities and county groups, aimed to identify community health problems facing Mercer County in the hopes of collaborating to solve them.
Contact Emily Brill at (609) 989-5721 or email@example.com.


text: Every summer, the regions' huntsmen lead guided dawn walks to observe fauna and flora, starting from a different place each time. You may see chamois, ibex, marmots and white ptarmigan. As well as being experts on animals, the huntsmen are also knowledgeable about local geology and plants. The excursion is free of charge, but you have to book in advance.


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Angered by a teenager's claims of being humiliated by a teacher over a Romney/Ryan T-shirt, students at Charles Carroll High School ignored warnings from administrators and shouted obscenities out school windows at the girl's parents Friday morning.
Samantha Pawlucy had accused her geometry teacher of humiliating her for wearing the shirt, and stayed out of school after saying she learned students had made threats against her. To calm the situation, district officials addressed students Friday, urging them to leave Pawlucy alone.
Minutes later, some students were heckling Pawlucy's parents, shouting obscenities at them.
The Pawlucys had gone to the school in Port Richmond to file a complaint against teacher Lynette Gaymon for allegedly harassing their 16-year-old daughter for wearing the shirt on "dress-down day" Sept. 28.


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Monday, January 4, 2010
Better 3G
More of Jason Taulb at Stunning Men...
Departing flights
The one permanent emotion of the inferior man is fear --
fear of the unknown, the complex, the inexplicable.
What he wants above everything else is safety.
-- H.L. Mencken
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Ulcerating lesions of the stomach are of frequent occurrence, and the possibility of their being malignant can never be ruled out except by microscopic examination. They are not infrequently associated with serious complications. Medical treatment of such ulcers has proved ineffective in a high percentage of cases. Gastric resection, on the other hand, can be done with a low mortality, and end-results with few exceptions are most gratifying. The purpose of this presentation is to submit evidence to show that these statements are true and to urge that all ulcerating lesions of the stomach be considered a surgical problem from the moment of diagnosis.
A comparison of the results of medical versus surgical treatment of gastric ulcers needs to be often repeated, not only to surgeons, especially those not primarily interested in gastric surgery, but particularly to internists, gastroenterologists, and general practitioners, who too frequently are reluctant to relinquish the
Thank you for submitting a comment on this article. It will be reviewed by JAMA Surgery editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
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Artist: W.A.S.P.
Album: Unholy Terror
Genre: Rock
I was here when time began
I was in them all
A wicked one magician's hand
I'm what John had saw
I'm a thing that lives and breathes
With slaves to worship me
There are many that are born of me
Anytime there are many me's
Crowned Messiah, I crucified him
And still ya don't believe
I am kings, I am queens
Unholy terrors me
I'm the feces of the species
Still you're all in awe
I'm something a Prophet saw
Hister with a rise and fall
Obsessed with Lennon
Manifested Marx
I'm incest
In the hearts of dark
Riding on some atomic bomb
To blind you all to kingdom come
I am, I am
I am, I am
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After traveling 250,000 miles through Dar al-Islam ("House of Islam") as Muslims call their world, career missiologist David Garrison came to a startling conclusion:
Muslim background believers are leading Muslims to Christ in staggering numbers, but not in the West. They are doing this primarily in Muslim-majority nations almost completely under the radar—of everyone. In the new book, A Wind in the House of Islam: How God is Drawing Muslims Around the World to Faith in Jesus Christ, Garrison takes the reader on his journey through what he describes as the nine rooms in the Muslim-majority world: Indo-Malaysia, East Africa, North Africa, Eastern South Asia, Western South Asia, Persia, Turkestan, West Africa, and the Arab world. Muslims in each of those regions have created indigenous, voluntary movements to Christ.
"What did God use to bring you to faith in Jesus Christ? Tell me your story." This was the core question Garrison asked as he traveled and conducted more than 1,000 face-to-face interviews. In his background research, he documented 82 historic Muslim movements to Christ, consisting of either at least 1,000 baptisms or 100 new church starts over a two-decade period. The first sizable movement of Muslims toward Christianity did not occur until the mid-19th century, nearly 1,300 years after Mohammad established Islam. Garrison said 69 of these movements today are still in process:
- In Algeria, after 100,000 died in Muslim-on-Muslim violence, 10,000 Muslims turned their backs on Islam and were baptized as followers of Christ. This movement has tripled since the late 1990s.
- At the time of the 1979 revolution in Iran, about 500 individual Muslims were following Christ. Garrison projects that today there may be several hundred thousand Christ-followers, mostly worshipping in Iranian house churches.
- In an unnamed Arab nation, an Islamic book publisher Nasr came to Christ through satellite broadcast evangelist Father Zakaria. Sensing a call to evangelize, Nasr started a local ministry that in less than one year baptized 2,800 individuals.
In total, Garrison estimates that 2 to 7 million people from a Muslim background worldwide now follow Christ. (This is a projection since a comprehensive count is not possible.) Timothy C. Morgan, CT senior editor, global journalism, interviewed Garrison recently.
You've spent your professional life in missions. Why undertake 30 months of grueling travel to remote parts of the Muslim world that you already visited?
This really marks an unprecedented turning to Christ. I don't think it's ever been captured in a global sweep as it has been here.
I've been involved in missions for 29 years. When my wife and I were working with Libyan Arabs in North Africa, we learned a lot of ways not to effectively win Muslims to Christ. But then we started seeing these movements. The numbers began to grow over the years. We found ourselves living in India for six years. I was director of Southern Baptist work in South Asia. We were able to see many of these Muslims who had come to Christ, to know them personally, and partner with them. We knew two men, one named Islam and the other named Mohammed, doing mosque-to-mosque evangelism. They were distributing Jesus films and New Testaments in the mosques. They saw a lot of Muslims come to Christ.
My colleagues approached me and said, "We're hearing more and more anecdotes of Muslim movements to Christ, and some of them we feel are legitimate. We need someone to go and find out."


text:
Thesp joins Jennifer Lawrence in Lionsgate pic
Willow Shields has been cast as Primrose Everdeen in "The Hunger Games" for Lionsgate.
Industry newcomer Shields joins a cast that includes Jennifer Lawrence, Elizabeth Banks, Liam Hemsworth and Josh Hutcherson.
Gary Ross is directing from a script by Billy Ray, based on the bestselling young-adult novel series by Suzanne Collins.
Nina Jacobson is producing through her Color Force shingle. Pic is set for production later in the year.
Shields is represented by the A&M Agency.


text:
Zero Dark Thirty
Jessica Chastain on Childhood Bullying: 'I Was Told Every Day at School That I Was Ugly'
Originally posted 10/07/2014 04:15PM
With three buzzed-about films – Interstellar, The Disappearance of Eleanor Rigby, and A Most Violent Year, due out this fall – Jessica Chastain is one of the most wanted women in Hollywood, so it's hard to imagine this commanding female lead spent her childhood being bullied by classmates.
What We're Reading This Weekend: True Stories
Originally posted 10/31/2013 05:00PM
The hunt for Bin Laden in Abbottabad, Chinese smuggling rings in New York City, a transformative drama program in Levittown – these unfamiliar worlds have our staffers transfixed at the moment. Let us know what you think of their choices – and tell us what you're reading.
Joel Edgerton Reveals His Biggest Fear
Originally posted 06/10/2013 09:50AM
Going mano a mano with Leonardo DiCaprio in The Great Gatsby isn't nearly as nerve-racking for Joel Edgerton as sharing the screen with some eight-legged costars.
In his new thriller Wish You Were Here, which hit theaters this past weekend, Edgerton is among a group of friends vacationing in Cambodia when one disappears.
"I have a massive fear of spiders," says Edgerton. "In one scene I had six tarantulas crawling on me! Luckily they had be de-fanged, had they not I don't think I would have been able to do the scene."
When he's not fighting his fear of spiders, here's five more things the hot Australian star, 38, gets up to:
Throw a Star-Worthy Oscar Party!
Originally posted 02/24/2013 03:05PM
It's Hollywood's Super Bowl – so if you're throwing an Oscar party, hot wings just won't do.
Instead of critiquing the gowns over cold pizza and nachos, check out these glam recipes that will rival what the stars are eating – or pretending to eat – at the posh post-Academy Awards bashes.
Jessica Chastain Makes First Public Appearance with Boyfriend
Originally posted 02/23/2013 01:30PM
Having recently told Katie Couric during an interview that she does have a boyfriend, Jessica Chastain made what is apparently her first public appearance with him Friday night, at the Women in Film 6th annual Pre-Oscar Cocktail Party.
Arriving arm and arm together at Fig & Olive in Los Angeles, the Zero Dark Thirty Best Actress nominee and Gian Luca Passi de Preposulo sipped Perrier-Jouët Champagne in the main room before Chastain spotted her costar from last year's The Help, Viola Davis, and Davis's husband.
Chastain, 35, hugged and kissed the 31-year-old Passi, making it clear to all who saw them that the two are, in fact, a couple.
Chris Pratt: How I Became the 'Stereotypical Soldier' on Set
Originally posted 01/27/2013 09:00AM
"It was this funny thing where I was always staring at a picture of my pregnant wife back home," the Zero Dark Thirty star says
Chris Pratt Enjoying 'Firsts' All Over Again with Son Jack
Originally posted 01/22/2013 01:00PM
The Zero Dark Thirty star also shares a video of he and wife Anna Faris feeding their 5-month-old a lemon
Ben Affleck, Kathryn Bigelow Biggest Oscar Snubs?
Originally posted 01/10/2013 01:05PM
Today might be the only day any of us will ever feel sorry for Ben Affleck. The nominations for the 85th annual Academy Awards were announced Thursday morning and the Argo director shockingly didn't make the cut.
But here's who did – and who should have:
Best DirectorThe shock: Two huge snubs! Not only did Argo's Affleck get dissed, even though he had one of the best-reviewed films of the year, but so did Zero Dark Thirty's Kathryn Bigelow, a previous Best Director winner for The Hurt Locker – which I'd argue isn't nearly the accomplishment that Zero Dark Thirty is. Both of the films about terror made the cut for Best Picture, however. But then, that was expected.
Academy Award Nominations: Lincoln Leads the Pack
Originally posted 01/10/2013 08:15AM
This year's Oscars may not take place until Feb. 24, but the ceremony's host, Seth MacFarlane, already started earning his salary Thursday morning – by joining Emma Stone to announce the nominees for the 85th annual Academy Awards from the Academy of Motion Picture Arts and Sciences' headquarters in Beverly Hills.
And the name that kept coming up: Lincoln, which reaped the lion's share number of nominations, 12, including those for Best Picture, Best Director Steven Spielberg, Best Actor Daniel Day-Lewis and Supporting Actress Sally Field.
Other highly recognized films were Life of Pi, with 11 nominations; Les Misérables, with nine; and Argo, with seven, though, surprisingly, not one for its director Ben Affleck.
Chris Pratt's Premature Son Is 'Totally Healthy Now'
Originally posted 01/03/2013 04:15PM
"Jack was born nine weeks premature so we spent a month in the intensive care unit with him," the Zero Dark Thirty star explains
The most buzzed about stars this minute!
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African Social News Network and Events
Entrance billboard of Guangzhou Canaan Wholesale Clothing Market (Photos:Gbooza!)
Guangzhou Canaan Export Wholesale Clothing Market, is located in the commercial district also know as the 'chocolate city' in guang yuan xi road,Guangzhou city,China.Established in early 2000's,Canaan wholesale Clothing market is well know for cheap, high quality clothing,shoes and fashion accessories.
It is an important destination for African traders, may be dubbed the "MECCA" of shopping for Africans in Guangzhou.No doubt Canaan Export Wholesale clothing market has positively boost Africa economy, improved livelihoods, gives hope to the low income earners, create jobs,put smiles on faces. As the name depicts, Canaan Export Wholesale market can be compare with the biblical Canaan land, a 'Land Of Hope'.
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Popular Diets
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Recent Enteries
Where as Julie Andrews in The Sound of Music prefers the simple things in life, like rain drops on roses and warm woolen mittens, Oprah prefers the fabulous, and she also likes sharing. That's great for the approximately 300 guests in her studio audience today, as they're going home with the most fabulous bundle of gifts the talk-show host has ever given away. Friday's Oprah's Ultimate Favorite Things (with a second audience receiving these gifts in a special episode today) is a farewell to this popular annual segment, as she enters the final half of her 25th, and final, season.
With more than 20 items on the list, including a cruise, jewelry, and one of our favorite organizations, KIVA, we were glad to see a few items that will help motivate people to get in shape. We thought you health-conscious individuals might enjoy them, too. And while we can't give them away in a confetti- and shriek-filled party, we can point you where to find to them. (more…)


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Watch movies with Jamie Renell online
Where Jamie Renell born?
With the help of the Google satellite map you can find the place where Jamie Renell was born. By zooming in and out you can see the place itself and the area it is situated in and nearby. Find out where Jamie Renell was born. Now you can see the place itself even not traveling.
Jamie Renell filmography
Here you can learn about the movies Jamie Renell acted in. You can see the names of the movies, their budget, years of release and the money gained from the screening of the certain movie. It is always interesting to know.
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Selena Gomez is buying a house
20-year-old actress and singer Selena Gomez is planning to start living on her own. She feels it's the right moment to move out of her parents' house and buy her own place. ''Yeah, you know I
Olivia Wilde: David Blaine asked me to drown him
Appearing on 'Late Night with David Letterman', Olivia Wilde revealed that magician David Blaine asked her to drown him but the actress refused to do it. She said: ''He wanted us to hold him under
Jessica Simpson planning wedding again
Doing a photo shoot for Us Weekly with her son Ace Knute, Jessica Simpson revealed that she and Eric Johnson will finally get married. The couple got engaged in 2010 and originally wanted to marry
Born on the same day
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I have been using this for years upon my vets recommendation.
Same as from the vet but at a much better price.
That a good product, the smile is OK, and let the dog ears in good condition.
I use this earwash on my ferrets all the time. It doesn't have a repelling smell like most other ear washes do and it keeps their ears smelling good, even a few days after using it. It's a good, sensative formula that does the trick!
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AME Foundation, as a resource organisation, has been promoting ecological agriculture for more than 27 years. AME Foundation has been guiding small and marginal rainfed farmers to manage their natural farm resources better, practice alternative eco-farming practices for enhanced yields and reduced costs. AMEF believes that sustainable management of natural resources is the key to improved livelihoods, stable agricultural development as well as improved ecological balances.
Kolar farmers harvest good yields in redgram
Farmers in Bangarpet taluk tried some principles of SRI in Redgram crop like lesser seed, transplanting seedlings of right age; wider spacing etc., harvesting around 6quintals per acre.
SRI - a new hope for cultivating paddy under less water conditions
Seenappa a farmer in Balamande village of Kolar district is excited to see 65 tillers per hill in his paddy crop and hopes to get a good harvest this season.
Magadi farmers to set up a community seed bank
Farmers in Guddahalli and Ukadda villages in Magadi taluk are all set to start a community seed bank in their village. Having got good yields by practicing a combination of sustainable...
Are you a reader of LEISA India
a quarterly magazine on ecological agriculture.
Are you interested in growing healthy food on your terraces?
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24 Simple Scrapbooking Layouts
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Best Friends Scrapbook Page
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Show off your favorite photo of your BFF with this cute idea using recycled paper. Make it into a photo frame or incorporate it into a fun scrapbook layout you can give to your bestie - just follow the steps for this best friends scrapbook page from Arnold Grummer's Paper Making Kits and Supplies!
- Arnold Grummer's Angel Wings: Multi Color Mix
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"A Unique Trip into the World of Nostalgic Flavor"
Rosie's Diner offers great food, breakfast all day and old fashioned handmade milkshakes and malts. Enjoy a Vanilla Coke or a frosty bottle of beer on our outdoor patio.
Open every day from 6am to 9pm
Join us Wednesday nights, May through October, for our weekly Cruisin Night. You will be transported back in time and immersed in 40 classic cars, food and fun for the whole family!


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In article
, "Dean M \(SkyNet
> Hi,
> I am having a problem connecting my WinXPPro clients to my Samba logon
> server.
> I can logon locally to the XP machines, and when I open the samba
> fileserver, it requests a password and then i can see the correct shares.
> When I try to logon to the domain, I get a message either saying...DOMAIN is
> not available...or cannot connect to DOMAIN.
> Here is a copy of the smb.conf
> Hope someone can help..ive been trying to figure this out for a week or so
Have you appled the signorseal patch to the XP pc??
If not there is a link to the patch here on my web site
Samba Setup Guide: www.samba.netfirms.com
My gpg public key: www.samba.netfirms.com/gnupg/gpg_public.asc


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indulge with a richer shade like a-list.step 1: hydrate with apricot cuticle oil.step 2: clean then prep nail with an essie base coat or treatment.step 3: apply 2 coats of a list. let dry. step 4: shine + seal with an essie top coat.
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Quadruple Helices Appear To Have Role...
Wall Street Decline Takes Its Toll...
Adapting to Evolving Business Environments Is...
Nothing Beats Immunoassays for Sensitivity, Specificity,...
Terrence Chew, M.D.
Biomedical companies, especially start-ups new to or unfamiliar with the FDA environment, that are developing a new drug/device combination or a nutritional product may enter a clinical trial unaware of regulatory requirements or may feel their company is too small to be subject to the usual requirements. This is not true—FDA maintains a single set of standards to which all companies, regardless of size, must adhere.
In order to ensure clinical trial compliance, the FDA has an ongoing bioresearch-monitoring program that includes inspections designed to evaluate the conduct of research and to ensure that the rights, safety, and welfare of the human subjects have been protected. FDA periodically publishes findings of inspections, which is a great resource to assess potential investigative sites or pharmaceutical partners.
A recent inspection of a small pharmaceutical company revealed that the company had failed to submit an IND for the conduct of a clinical investigation with an investigational new drug. In addition, it failed to obtain necessary documentation to ensure compliance with the clinical protocol and subject protection such as a Statement of investigator that includes a commitment from the investigator to comply with the protocol, personally oversee the investigation, meet informed consent requirements, ensure that IRB review and approval requirements are addressed, and disclose financial information.
In addition, the sponsor did not maintain adequate records regarding investigational drug disposition and did not monitor the progress of the trial with a qualified monitor. All of the above are required by law and relevant FDA guidelines. Companies often feel that they are exempt from these regulations as they are not developing a new drug or they are just conducting pilot studies to make decisions.
Common clinical investigator compliance issues include failure of the investigators to conduct the study in compliance with the protocol and signed investigator plans. In addition, investigators may incorrectly feel that they can modify the protocol for specific patients, which is different from the protocol's standard of care. FDA inspectors compare the protocol inclusion and exclusion criteria versus the patient records to look for such violations.
Although, investigators may ask the sponsor for an exemption—these must be considered carefully to determine their impact on the study results and statistics. FDA may examine the quality of the informed consent for adequacy in terms of explaining risk, and to ensure that informed consent was obtained prior to the patient being treated on the protocol. FDA may also audit IRB adherence to its own rules and regulations.
Companies that sponsor clinical trials are responsible for the compliance of their investigators. Since many trials are being performed outside the U.S., companies must ensure that investigators are properly trained equivalent to U.S. medical standards of practices and monitored to maintain compliance.
Although costs may be less in certain ex-U.S. regions, this must be balanced by the increased cost of properly monitoring distant sites. There are many valid reasons to conduct trials outside of the U.S., but sponsor companies must be sure that the lower cost is not due to lower quality, especially since EMEA and FDA have increased the inspection of non-U.S. pivotal studies.
--Terrence Chew, M.D. ([email protected]), is a clinical development expert with over 25 years experience in FDA regulatory and clinical studies issues.
Bruce F. Mackler, Ph.D., J.D., a senior advisor in FDA matters, is lead contributor to GEN's "Spotlight on the FDA" column. Web: www.brucemackler.net.
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While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
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Single Article Purchase:
Severe Hypokalemia in Hospitalized Patients
Lawson DH, Henry DA, Lowe JM, Gray JB, Morgan H.
Arch Intern Med. 1979;139(9):978-980.
Published online September 1, 1979
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Spring/Autumn planting. Softneck garlic.
Well-known and reliable, Garlic 'Germidour' comes from French production that is well adapted to British conditions. This softneck variety produces large, white bulbs with a mild but still rich flavour. Height: 60cm (24"). Spread: 15cm (6").
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STELLAR: Wilson WL boys, Northwestern girls move on
Published: 6:45 PM EDT Jul 14, 2013
The Wilson West Lawn boys and Northwestern girls each had strong showings Sunday in the early action at the Stellar Basketball Showcase.
Wilson, which had beaten Whitehall and Allen on Saturday, beat Glen Mills and Central Catholic to take an unbeaten record into the winners bracket semifinals.
Northwestern beat Nazareth and Southern Lehigh in the winners bracket semifinals and finals.
The Stellar championship games will be played Sunday night.
Tune into 69 News Weekend Edition at 10pm for the highlights.
Copyright 2013 WFMZ. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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|Educational Videos, Lessons and Games for K-12 School Kids
Oceans are large bodies of salt water that cover nearly three-fourths of the Earth's surface. The average depth of the oceans is nearly 3800 meters. The world's ocean comprises of 5 divisions - Pacific Ocean, Atlantic Ocean, Indian Ocean, Southern Ocean and Arctic Ocean. Life on Earth first originated in the oceans, almost 3 billion years before life occurred on land. Oceans have a huge influence on the Earth's climate.
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Washington, DC (June 21, 2012) - The U.S. Supreme Court ruled 7-2 today, siding with nonmember California state employees challenging a Service Employees International Union (SEIU) political fee charged to them without notice and opportunity to opt out.
The case concludes a prolonged legal challenge affecting some 36,000 California government employees initiated by eight California civil servants who filed a class-action lawsuit with free legal assistance from the National Right to Work Legal Defense Foundation.
In 2005, SEIU officials imposed a "special assessment" to raise money from all state employees forced to accept union representation as a job condition for a union political fund, regardless of their membership status. The fund was used to defeat four ballot proposals, including one that would have revoked public employee unions' special privilege of using forced fees for politics unless an employee consents. Employees who refrained from union membership were given no chance to opt out of paying the SEIU's political assessment.
Mark Mix, President of National Right to Work, issued the following statement regarding today's ruling:
"Today, the United States Supreme Court upheld workers' First Amendment rights and struck down another union boss scheme to confiscate and spend state workers' hard earned money for politics without their permission.
"Attorneys from the National Right to Work Foundation – the nation's leading advocate for workers who suffer from the abuses of compulsory unionism – argued, and the Court agreed, that the workers should not be forced to subsidize union officials' political spending, even for a short period of time.
"The Court closed a giant loophole that allowed union bosses to confiscate money from workers' paychecks for political spending sprees – and sent a message to union officials, once again, that forced political conformity is unconstitutional."
For more information on the case, please visit the National Right to Work Foundation's Knox Supreme Court case page at http://www.nrtw.org/en/knox/ [1].
[1] http://www.nrtw.org/en/knox/


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Hoosiers hammer Huskers in 10-2 win
LINCOLN – Against average opponents, a few mistakes may not kill a team. Against the preseason conference favorite with a pivotal series win on the line, even one can be the difference.
Nebraska made a few more than that against No. 17 Indiana on Monday at Haymarket Park.
The Hoosiers scored 10 runs on 11 hits and nine Nebraska walks to take a 2-1 series victory and drop the Huskers one game back in the Big Ten standings with six games left to play. But the Huskers' struggles on the mound were only half the story.
Indiana (36-9, 13-5) got a stellar outing out of starter Aaron Slegers. The sophomore threw 8.1 innings, striking out three and, most importantly, walking none in the win.
"They walked zero, we walked nine — end of story," Erstad said summing up a frustrating loss for the Huskers.
Before getting back-to-back hits to leadoff the ninth, Nebraska (21-25, 12-6) managed just two hits over the first eight innings off Slegers and put just six runners on base.
"He's a tall guy (and) he's got a good angle to his fastball," Erstad said of the 6-10 Slegers. "It's very difficult to get your barrel behind the baseball of a guy who's pitching down in the zone. He didn't even have to use his off-speed stuff too much."
Indiana, on the other hand, put the leadoff man on in seven out of nine innings, five times via walk or a Nebraska error. In a sign of things to come, the Hoosiers claimed a 1-0 lead in the first inning without recording a hit when centerfielder Justin Cureton walked to leadoff the game, stole second, advanced to third on a sacrifice fly and scored on a passed ball.
But Indiana can hit when given the opportunity too. Holding a 2-0 lead in the fifth, designated hitter Kyle Schwarber walked to leadoff the inning, chasing Nebraska starter Aaron Bummer from the game. Reliever Ryan Hander retired the next two batters before giving up a single to shortstop Michael Basil to put runners on the corners. Third baseman Dustin DeMuth broke the game open, ripping a 2-2 pitch to right for a three-run homer. It was Indiana's fourth home run of the series. DeMuth finished the day 2-for-5 at the plate with four RBIs and two runs scored.
The closest Nebraska came to threatening the Hoosiers was in the bottom of the eighth when right fielder Austin Darby reached on a throwing error to leadoff the inning. The next batter, shortstop Bryan Peters grounded sharply to third and it looked like DeMuth's throw pulled second baseman Nick Ramos off the bag. The umpire called Darby out, drawing Erstad out of the dugout to argue to no avail. Sanguinetti singled later in the inning to put two on, but Slegers got Michael Pritchard to fly out to end the inning.
Nebraska pieced together four hits in the ninth – two off Slegers and two off reliever Scott Effross – to score two cosmetic runs. Bummer (1-1) took the loss for Nebraska, walking five and giving up three earned runs over four innings.
The loss gave Indiana sole possession of second place in the Big Ten behind 11-4 Minnesota. Nebraska sits in third at 12-6 pending the result of Monday's Northwestern-Ohio State game.
That sets the stage for another key three-game series for the Huskers next week as Nebraska visits Minnesota. Erstad said Nebraska will have to hone its focus if it expects a different result next weekend.
"(We) still have a chance at the two-seed," Erstad said. "There's still six games left so who knows what can happen? At the end of the day, I'm more concerned about how we're going about our business."
Nebraska opens the series against the Gophers at 3:05 p.m. on Friday, May 10 followed by afternoon games on both Saturday and Sunday. All three games will be streamed live at BTN.com.
[nggallery id=53]


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TELL CITY—A constant for Perry Central's girls basketball team has been strong defense, and it carried the Commodores past Tell City 42-21 in the Class 2A sectional semifinals Friday.
The Commodores held the Marksmen to 31.0 percent field-goal shooting and limited them to 29 shots by forcing 19 turnovers and outrebounding them 39-24.
Limiting the number of Tell City shots was important because the Commodores hit only 31.4 percent from the field themselves. But they had 22 more attempts and also got to the foul line four more times.
LYNNVILLE—Cannelton could not overcome its shooting woes in a 71-47 loss to Tecumseh in the girls Class A basketball sectional semifinals Friday.
The Bulldogs hit just 10 of 40 field goal attempts for the game for 25 percent, while the Braves connected on 25 of 52 for 48.1 percent.
The Braves started the game shooting the ball well on their home floor as they built a 26-12 first-quarter lead.
The Bulldogs seemed to settle down a little in the second quarter and outscored the Braves 11-9 in the period to go into halftime down by 12 points.
Jim Sprinkle and Nick Sears, two of the men who will be inducted into Tell City High School's Athletic Hall of Fame Friday, both went into coaching after playing four sports at Tell City and one in college.
Both no longer coach, but both have remained active in sports.
After coaching boys cross country one year at Perry Central and boys and girls swimming at Mount Vernon and Vincennes Lincoln, Sears, 31, is in his first year as athletics director at Indian Creek High School.
DUBOIS—Wes Knies scored 12 points in the fourth quarter as Northeast Dubois overtook Perry Central for a 51-46 boys basketball victory Thursday.
Perry Central led at the end of each of the first three quarters, building its lead to nine points once.
But the Commodores had trouble stopping Knies, a 6-foot-2 junior forward in the final period.
"We talked about him being one of their better scorers—him and (Trevor) Atkins," said Perry Central Coach Matt Carter. "And we did a pretty good job on Atkins.
EVANSVILLE—Evansville North outplayed Tell City in nearly every phase of the game to trounce the Marksmen 65-39 in boys basketball Thursday.
The Huskies outshot Tell City from the field 49.1 percent to 28.6 percent, including a 42.9 percent to 21.1 percent advantage in three-point shooting.
Their superior leaping ability helped them outrebound the Marksmen 39-27.
The Marksmen did not grab a rebound in the first five minutes as they fell behind 17-3.
FERDINAND--Perry Central's varsity and JV boys basketball games at Forest Park, scheduled for Monday, Feb. 15, have been postponed to Wednesday, Feb. 17, at the same time.
This is the second time these games have been postponed due to snow.
JASPER—Tell City won four events and placed second in five to finish second in the 13-team girls swimming sectional Saturday.
No other team won more than two of the 12 events. But Jasper used its depth to beat Tell City for the title 286-247.
Only first-place finishers were guaranteed to advance to this weekend's state meet.
LEOPOLD—Ian Hahus blocked Mac Webb's shot at the buzzer to preserve Perry Central's 61-60 boys basketball win over South Spencer Saturday.
"We went to a full-court, man-to-man defense and pressured them into a tough shot," said Perry Central Coach Matt Carter. "It came up short. Ian knew (South Spencer) had a second to catch and shoot and he timed his jump."
South Spencer's Tristan Brown, hobbling on an injured ankle, made a three-point shot from the volleyball spiking line to tie the game 57-57 with 1:35 left.
FORT BRANCH—Gibson Southern hit 60.5 percent from the field to beat Tell City 61-58 in overtime in PAC boys basketball Saturday.
The Titans scored all 20 of their two-point field goals on layups—some on drives, some on backdoor cuts, two on offensive rebounds, and one on a fast break off a Tell City turnover.
When Tell City played a zone defense, the Titans would make several passes to try to spread the zone out and then attack the middle with a pass or drive.
Against man-to-man defense, they often made successful backdoor cuts.
CANNELTON—Cannelton could not overcome a hot start by Hancock County as the Bulldogs lost 97-71 in boys basketball Saturday.
Trailing 3-2 just over two minutes into the game, the Hornets found their shooting touch. They made nine three-pointers in the next eight minutes, outscoring the Bulldogs 38-14.
The Hornets shot 52.9 percent for the half, including 9 of 15 from three-point range, to build a 49-23 halftime lead.
Mark Harris hit five three-pointers in the first-half and Nolan Braun made three.
Copyright © 2016
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


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- Redesigning Your Site? Don't Make it Harder for Google to Extract the Text: Google posted one of the Matt Cutts … http://bit.ly/nMZCxO #
- qod: in silence the truth can at last speak #
- Google Made a Minor Tweak to the Panda Update: Google makes hundreds of changes to its algorithm every year. Som… http://bit.ly/ogYpVy #
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Archive for July, 2011
Twitter Weekly Updates for 2011-07-31Sunday, July 31st, 2011
Twitter Weekly Updates for 2011-07-24Sunday, July 24th, 2011
- Google May Sticky Search Box, Navigation Bar: A Google design tweak being tested would see the bar at the top of… http://bit.ly/nSWIVX #
- The Google Directory is No More: While I'm not sure of the viability of directory submissions as a way of search… http://bit.ly/qRyrmv #
- SEO Developments You Need to Know About: Much of the Google talk lately has been centered around Google+, the co… http://bit.ly/pr1GnT #
Twitter Weekly Updates for 2011-07-17Sunday, July 17th, 2011
- Need to edit or resize images for the web. Try the free website http://www.pixlr.com get free instructions at Foxcom.co.Uk – useful stuff #
- We are looking for a student looking for work experience / holiday placement in web and CMs . Based on the outskirts of Huddersfield. #
- A Holistic Look at Panda with Vanessa Fox: Vanessa Fox, called a cyberspace visionary by Seattle Business Monthl… http://bit.ly/n1vNjE #
- Google Panda Update: The Solution for Recovery?: Many sites are still wondering how they can come back from bein… http://bit.ly/oJcHUh #
- @foxcomgf and it wasn't even that great #
- If u don't innovate your'e dead. Another person will be innovating round the corner. #
- "simple and thought provoking, that people want to pass onto others & see again- makes the best adverts." Robert senior saatchi & saatchi #
- @assistoffice that happened to me last year. Now I have a new company car #
- Regrets are a waste of time they are the past crippling you in the present . #
Twitter Weekly Updates for 2011-07-10Sunday, July 10th, 2011
- Why Google+ could find a home in the workplace http://t.co/kVvjACI #
Twitter Weekly Updates for 2011-07-03Sunday, July 3rd, 2011
- small businesses can save time by using viapost to send invoices by post- without ever having to go to the post office. http://t.co/MrIi2za #
Why you cant see flash on your iPhone nor are ever likley too.Friday, July 1st, 2011
Its very fustrating for us web developers, that Apple wont allow Flash- the animated gizmo that many websites use either wholy or partly to show animations, videos etc. on their iPhone. Evere wondered why?
Well here is the full story:
Apple are terrified that you'll be able to use it to download music and videos and bypass their dreaded itunes store. Thats it in a nutshell.
"Flash is Adobe's highly popular platform for displaying interactive graphics, animations and multimedia within a browser. According to Adobe, 98 percent of desktop computers currently support Flash, which has led to its widespread use by web developers. Adobe's recent announcement that it is working on a version of Flash for Windows Mobile has prompted speculation that an iPhone version might be coming soon. "
taken from this article, click the link to read in full.
So what to do, As a web developer we are looking to use jquery more and more for banner animations, as this WILL work on all phones. Its not the complete answer I know, but it works for now.


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Recent Event Highlights: S. Portland chemical plant faces EPA fine - The Forecaster, CSB renews call for local chemical safety program - Charleston Gazette, Video of giant chemical plant blast, toxic cloud poisons Canberra, Worker Dies From SKF Plant Explosion Injuries - WGAL Lancaster, Chemical Plant That Exploded May Be Fined $917K - WCVB-TV, Blast at chemical plant kills 3 - The Nation, Pakistan, and 202 more...
Created by dipity on Feb 8, 2010
Last updated: 09/23/11 at 04:58 AM
S. Portland chemical plant faces EPA fineThe ForecasterThe complaint alleges the facility stored incompatible chemicals close enough together that a spill or release of one chemical could result in a reaction with others, creating toxic gases, fire or an explosion. The EPA alleges the plant violated ...and more »
CSB renews call for local chemical safety programCharleston GazetteBoard members voted 4-1 to approve the report, along with its recommendation that the Kanawha Valley create a new chemical plant safety program aimed at preventing future leaks, explosions and fires. "The board continues to feel that's an important ...and more »
Worker Dies From SKF Plant Explosion InjuriesWGAL LancasterThe Sept. 1 explosion at the SKF USA Inc. plant left a worker and two contractors injured with chemical burns. Company officials said the workers suffered respiratory burns while working with a salt solution that is used to treat metal. ...and more »
WJFW-TVBlaze at Wis. co-op does $500000 in damageHouston ChronicleThe blaze destroyed seed and chemical warehouses and damaged a facility where liquid fertilizer is loaded. Leick said the explosion sounds came from a pair of 120-gallon propane tanks. The tanks didn't explode but, as designed, released propane vapor ...Massive fire at Adell Co-op forces village evacuationFond du Lac ReporterExplosion, fire at Sheboygan County farm co-opWHBL Sheboyganall 83 news articles »
Chemical Plant That Exploded May Be Fined $917KWCVB-TVBOSTON -- The federal workplace safety agency has recommended $917000 in fines for a Massachusetts adhesives manufacturer after an explosion there injured four workers. The Occupational Safety and Health Administration on Tuesday announced it had cited ...OSHA cites 50 safety violations, proposes US 917000 in fines against Bostik Inc.MMD Newswire (press release)all 130 news articles »
Blast at chemical plant kills 3The Nation, PakistanBEIJING (AFP) - Three people were killed and another three wounded in an explosion at a chemical plant in east China on Tuesday, the official Xinhua news agency reported. The cause of the explosion at the privately owned plant in Leping city, ...and more »
3 killed, 3 injured in chemical plant explosion in ChinaPhilippine StarNANCHANG (Xinhua) – Three people were killed and another three wounded in a chemical plant explosion on Tuesday in eastern Jiangxi Province, local authorities said. The explosion happened at around 1:30 pm at the privately owned Jiangxi Jiangwei High ...Three Killed In China Chemical Plant ExplosionRTT Newsall 9 news articles »
CBC.caWSJ 3nd UPDATE: Explosion At French Nuclear Facility Kills 1,Hurts 4Wall Street JournalEDF confirmed the explosion at the incinerator, which doesn't generate electricity, but said there were no radioactive or chemical leaks as a result. Nuclear experts in France were quick to play down the impact of the fire at the waste treatment ...French nuclear officials downplay risks from blastCBC.caFrench officials: 'Don't worry about fatal nuclear explosion'RegisterExplosion at French LLW Plant Leaves 1 dead, 4 injuredEnergy CollectiveMirror.co.uk -NTDTV -Canada.comall 1,380 news articles »
One worker injured in blast at chemical plant in NiagaraBuffalo NewsOne worker was treated at Mount St. Mary's Hospital in Lewiston, then released, following the chemical explosion Friday night at Stollberg Inc., a manufacturing plant in the Town of Niagara. No other injuries were reported in the explosion that ...Authorities give "all clear" after chemical fireWIVBInvestigation Continues In Niagara Falls Industrial FireWGRZ-TVAll Clear Given In Niagara County Chemical ExplosionWBEN 930Tonawanda Newsall 27 news articles »
Fire marshal: Flammable vapors caused Middleton plant explosionBoston GlobeThe office said it had also issued three non-criminal notices of violation to the company and was recommending changes in laws and regulations to improve chemical process safety in the state. The violations were for storing more flammable liquids than ...and more »
...on these plants would harm the densely populated communities around them. The worst case scenarios the DHS found include chemical explosions, spills, and gas clouds that could either kill or seriously harm millions of people living in the plants' vicinities. But...
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"NEW IBERIA, La. (AP) - State police say nobody was hurt when explosions rocked a Multi-Chem Corp. chemical plant in a New Iberia industrial park Tuesday afternoon. Trooper Stephen Hammons says all employees are accounted for. He says Iberia Regional Airport was closed, and a 1-mile area around the plant was evacuated. Iberia Parish sheriff's deputies closed Louisiana Highway 182 on the western side of the city, about 75 miles west of New Orleans. The Daily Iberian newspaper reports that explosions could be heard 20 minutes after the first, which was about 4 pm A spokesman for Multi-Chem Group in Houston said the company was gathering information on what happened. The company makes oilfield production chemicals." www.klfy.com -------------------------------------------------------------------------------- All of the employees are "accounted for" but not dead, it sounds. Good. Now, just WTF is going on in this world and are these isolated incidents or some secret war or what @_@! ****SONG: Wonkap - Eliminate
Shep told viewers of reportedly massive explosions at a chemical plant in New Iberia, Louisiana, about 100 miles west of New Orleans, The cause of the explosion is unclear but so far at least four workers have been taken to the hospital.
Huge Chemical Plant Explosion @ Chemical Coatings LLC in Hudson, Nc on 5-28-2011. There are a total of 20 fire departments on this fire. They have issued a MADATORY 2 mile evacuation and a Optional 5 Mile Evactuation. photo on INITIAL EXPLOSION www.facebook.com HUDSON, NC -- A fire at a chemical manufacturer in western North Carolina has forced the evacuation of people living within two miles of the plant. Authorities say the Chemical Coatings plant near Hudson in Caldwell County caught fire shortly before 4 pm Saturday. Emergency officials say one person was taken to the hospital, but the extent of that person's injuries was not known. Authorities have shut down US 321 in front of the plant as firefighters battle the blaze. Evacuations were ordered as smoke filled the air. Chemical Coatings makes dyes, lacquers and other coatings for furniture and other products. Hudson is located about 70 miles northwest of Charlotte. Source of Info: www.sacbee.com Video is My own Shot off my back deck DO NOT COPY MY VIDEO AND POST ON YOUR OWN CHANNEL I FUCKING HATE THAT SHIT!
Yahoo News: news.yahoo.comTwitter - DIGG - Google -Buzz - Fark - Delicious - CNN ireporter - SKYNews - Reddit - "Hot Topics" Tokyo Latest News - NewsItemsToday - International News - World News - Global News - Chernobyl - RSOE Google Earth nuclear-event Nuclear-power-plant melt-down radiation radiation-monitors
On April 19, 1962 a pre-dawn blast at a huge ethanolamine chemical plant owned by the Olin Corporation in Brandenburg, Kentucky, almost leveled the complex installation. A small quantity of ammonia gas mistakenly introduced into a 6500-gal ethylene oxide tank (not 10000 as mentioned in the newsreel) triggered an exothermic polymerization and an explosion that shattered windows miles away. One plant worker was killed and 21workers were injured. Exothermic runaway reactions may occur when impurities or foreign materials are present in the storage tanks. The 1984 release of methyl isocyanate vapor from a storage tank at a Bhopal, India chemical plant was caused by the exothermic reaction of liquid methyl isocyanate with water. Over the past 50 years, hundreds of similar explosions and releases have occurred, tragedies that could have been avoided if good engineering in design, construction, maintenance and operation had been practiced and safety management program had been implemented and executed. That was the goal of Clean Air Act Amendments of 1990 passed by Congress which required OSHA and EPA to issue and enforce regulations to help prevent accidental chemical releases. OSHA has responsibility for the protection of workers from accidental chemical releases and has promulgated the Process Safety Management Standard (29 CFR 1910.119) to satisfy this requirement. EPA has responsibility for protection of the general public and the environment from accidental chemical ...
Harris Faulkner reports that a contract worker is still unaccounted for in yesterday's explosion at a Houston-area petroleum plant. The cause of the explosion is still under investigation.
Home vid of explosion Feb 2011
Chemical & Engineering NewsGoodbye, PhosphatesChemical & Engineering NewsInvestigation: Rush to production caused plant explosion in West Virginia, safety board concludes. On July 1, 2010, major cleaning product manufacturers ...and more »
Chemical & Engineering NewsBanking On Green ChemistryChemical & Engineering NewsInvestigation: Rush to production caused plant explosion in West Virginia, safety board concludes. Aiming for leadership in bio-based chemicals, ...and more »
Canaan Averts Disaster in Leaking Propane Tank Incident (Web First)Litchfield County Times... when the chemical combustion of water and magnesium caused some minor explosions and sent flames shooting through the roof vents of a storage facility. ...and more »
Safety board proposal leaves doubtDaily Mail - CharlestonThe safety board said the accident was caused by a runaway chemical reaction that occurred during the restart of the plant's methomyl unit. ...
West Virginia MetroNewsChemical Plant Explosion AvoidableWest Virginia MetroNewsThe US Chemical Safety Board says the deadly explosion at Bayer CropScience Plant in Kanawha County in August of 2008 should never have happened. ...Report: Fatal Bayer blast 'should never have happened'Charleston GazetteBoard: Mistakes Led to Bayer Plant Blast in W.Va.ABC NewsLongstanding Flaws Led to Deadly Blast at Pesticides Plant, Probers SayFairWarningWHSV -WOWK -Chemical & Engineering Newsall 117 news articles »
OSHA lists violations against plant where workers diedPittsburgh Post Gazette... violations against a Monaca-based chemical plant following an investigation into an explosion that resulted in the death of two employees there in July. ...and more »
3 Workers Hurt In Chemical ExplosionWHNS GreenvilleInvestigators said that the fire appeared to be the result of a chemical explosion that happened while the victims were working with a metal called ...Business Explosion Sparks Fire, Injures 3WYFF GreenvilleThree People Burned In Spartanburg County Business FireNews Channel 7all 10 news articles »
Questions remain on eve of final Bayer reportCharleston GazetteLast week's announcement that Bayer CropScience will stop making, using and storing the deadly chemical methyl isocyanate, or MIC, may have taken some of ...and more »
WVNS-TVBayer CropScience to eliminate 220 jobs in W.Va.BusinessWeekTwo workers were killed in an explosion involving a tank of the chemical there in 2008. Hedrick said Bayer plans to use up remaining stores of the chemical, ...Bayer to phase out MIC; cut 220 jobsCharleston GazetteBayer to cut production, 220 jobs at InstituteDaily Mail - CharlestonBayer to shut controversial US methyl isocyanate unit in 2012ICIS (subscription)all 60 news articles »
After eight hours still no control over the situation there .Southern areas of the Netherlands are on the top state of alert after a blaze at a chemical plant near Rotterdam sent out a thick plume of smoke. The cloud from the fire at Moerdijk was floating north and had reached the city of Dordrecht, Dutch media said. Some 400000 litres of carcinogenic material are stored at the Chemie-Pack plant, De Telegraaf says. There were no reports of casualties and officials said it was unclear if toxic fumes had been released. The flames were said to be up to 40m (131ft) high and there were reports of repeated, loud explosions. Residents in Dordrecht were being warned to keep windows and doors shut. A Dordrecht resident , said people in the area were frightened as they were unsure about any potential risks to their health. "It is quite scary. The sky is thick with black smoke and we still don't know if it is toxic or not. "There is a very unpleasant, chemical smell in the air. I could see the chemical site from my window at work this afternoon across the water and I only live two miles from there. "But we have not been given any information from the authorities and there is no number to call to find out more. It is frightening." The Dutch government set up a co-ordination centre for emergency services and southern areas of the province of South Holland were placed on their highest state of alert. Chemie-Pack, which is about 40km (25 miles) south of the port of Rotterdam, processes ...
Environmental agencies in the Netherlands are concerned after flames engulf a chemical plant. . Follow us on twitter at twitter.com .
...a major blaze and explosions ripped through a chemical storage and packing company. A plume of smoke billows from a burning chemical plant as firefighters are seen outside the plant in the southern Dutch town of Moerdijk, Netherlands, Wednesday, Jan. 5, 2011....
Source Info
Centre Daily Times
Charleston Gazette (blog)New Cumberland Council Expected To Discuss Triple-Fatal Explosion MondayWTOV SteubenvilleNearly a month after a chemical plant explosion claimed the lives of three workers in Hancock County, officials said few answers have been found. ...Community raises concerns following fatal explosion at New Cumberland metals ...Charleston Gazette (blog)all 7 news articles »
For more news visit ☛ english.ntdtv.com An explosion at a chemical plant in Shanxi Province has left four dead and 37 workers injured. It happened at the Yushe Chemical Industry on Saturday. The flames were put out by Sunday morning. The cause of the explosion is still under investigation. The company has 2700 employees and produces PVC, sodium hydroxide, and other chemicals.
this video is taken from discovery channel.. this video is uploaded for viewing purpose only..
akki sehrawat
Orlando SentinelDisney, SeaWorld accident lawsuits face tough oddsOrlando SentinelThen in 2000, the court opened the window wider: In a case stemming from an explosion at an Alachua County chemical plant that killed one worker and ...
Fears of chemical explosion at auto storeHerald SunSOUTH Australian police have set up a 500m exclusion zone around an Autopro store in Clare amid fears of a chemical explosion. ...and more »
San Bruno pipeline declared high risk by stateExaminer.comAccording to the US Chemical Safety Board (CSB), a number of explosions, going back to 1997, were caused by improper purging. ...and more »
Washington PostBP internal investigation report leaves some things unsaidWashington PostOil giant BP laid much of the blame for the rig explosion and the massive Gulf of Mexico spill on workers at sea, other companies and a complex series of ...and more »
NEWS.com.auSan Bruno Update: How safe are gas lines running under populated areas?Examiner.comThen, without warning, an explosion ripped through the quiet San Bruno neighborhood. Those closest to the epicenter of the blast, had seconds to escape the ...cutting natural gas criticalSan Francisco ChronicleAt Least Four Dead, Dozens Injured, in Massive Gas Line Blast Near San FranciscoFairWarning (blog)all 4,947 news articles »
Vacant lot at Pacific Street & Iwilei RoadHawaii News NowInvestigators say vapors from a chemical reaction underground led to three explosions. "It was more startling than anything. It didn't like shake where I ...Explosions In Iwilei Force Mid-Day EvacuationsKITV HonoluluHazards cleared after explosions in IwileiKHON2all 23 news articles »
Space.comSupernova Shrapnel Discovered Inside MeteoriteSpace.comBy contrast, Type Ia supernova explosions occur in the death of a small but extremely dense white-dwarf star in a binary system (in which two stars orbit ...Stellar Explosion Remnants Found in MeteoriteSoftpediaScientists discover supernova shrapnel in meteoriteOneindiaall 21 news articles »
CaryCitizenNo injuries at Cary chemical plant explosionNews & ObserverCary town officials said no one was injured in an explosion Thursday at an organic chemical company. The explosion occurred Thursday afternoon in a lab at ...Cary firefighters respond to explosion at chemical companyWRAL.comFire crews respond to lab explosion in CaryNews14.comExplosion in Cary lab forces evacuationBizjournals.comCaryCitizen -MyNC.comall 10 news articles »
Town HallEXPLOSION UPDATE: Kleen Energy, O&G, Bluewater named in new lawsuitsMiddletown PressMIDDLETOWN—Nine additional lawsuits were filed with regards to the Kleen Energy Power Plant explosion Thursday and lawyers ...Kleen Energy's fatal deal - Full versionCNNMoney9 new lawsuits filed over February plant explosionLexington Herald Leaderall 105 news articles »
APNewsBreak: 12 states warned about faulty propaneThe Associated PressBOSTON — An Illinois-based gas distributor has warned officials in at least 12 states that some propane deliveries may have lacked enough of a chemical ...and more »
Here's the Pepcon explosion in really great quality. I know it's still not the best quality that's out there, but I noticed it might be better than most of the ones here on Youtube. It's unedited, meaning I didn't add any sound effects or alter the original video in any way. The second explosion is so fuckin' awesome. It's the first explosion I ever seen where you could actually hear the sound wave as it's approaching. Sounds sorta like a jet engine right before the explosion.
Meth arrests follow barn fireHenderson GleanerInvestigators determined the fire began because a chemical reaction in a two-liter plastic soda bottle triggered an explosion. Police also found several ...and more »
CBC.caTesoro Refinery Fire May Be Worst Since BP in 2005BusinessWeeks Anacortes, Washington, refinery today may be the worst fatal accident to strike a US refinery since a 2005 explosion killed 15 people at BP Plc's plant in ...US to probe fire at Tesoro Anacortes refineryReutersTesoro refinery explosion kills 4Houston ChronicleDeadly Washington blast is latest refinery accidentLos Angeles TimesSeattle Post Intelligencer -The Associated Press -Seattle Timesall 1,546 news articles »
Seattle Post IntelligencerEvacuated families will not be allowed home before MondayWAFB.comEntertainment News from AP DENHAM SPRINGS, LA (WAFB) - Officials monitoring the huge chemical fire that sparked in Denham Springs this week report the ...Fire at La. chemical warehouse forces evacuationsThe Associated PressWAFB Channel 9, Baton Rouge, LA |Neighbors return home after chemical fireWBXHNeighbors of La. chemical fire still evacuatedAtlanta Journal ConstitutionNOLA.com -2TheAdvocate -The Associated Pressall 303 news articles »
Scientific AmericanExplosive Silicon Gas Casts Shadow on Solar Power IndustryScientific AmericanIn 2005 a routine procedure at a manufacturing plant in Taiwan caused a spontaneous explosion that killed a worker and ignited a blaze that ripped through ...


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1# robert pattinson and kristen stewart
A beloved couple on and off the big screen, Rob and Kristen are two of the most stunning stars in Hollywood. Whether they're fancied up on the red carpet or playing it cool in front of the paparazzi, they always manage to make a statement.
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minimalobsession by Tomokot on EyeEm
Hey friends,
welcome to your new weekly mission: Simplicity. It's the simple things in life that count, right? Capture them, frame them and submit them to our weekly mission!
Deadline: Monday, February 4, 2013
Reward: the 25 best submissions get featured right here on the EyeEm Blog.
How to take part: just take a photo and tag it with Simplicity at the upload screen – your photo is then automatically added to the album.
What are you waiting for? Go out and give it a shot!
abstractporn by David Crunelle on EyeEm
streetphoto by Nicanor García on EyeEm


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The Westbrook College Campus of the University of New England invites the
submission of proposals for individual papers or thematic sessions on
Women's Private Writing/Writing Women's History for an interdisciplinary
conference June 15-18, 2000. The conference program committee welcomes
submissions on any aspect of women's private writing including papers
which explore women's lives based on manuscript documents, papers which address
methodological and/or theoretical issues surrounding the use of diaries,
journals, letters, and other manuscripts, and papers which explore how
manuscript materials can be used in elementary, secondary, and university
educational settings to enhance the study of women's lives. In addition,
we encourage papers concerning the preservation of manuscripts and the use
of technology with manuscript materials. We welcome participation from
educators of all levels, librarians, archivists, museum professionals and
those interested in women's writing and history.
This conference highlights the rich resources of the University of New
England's Maine Women Writers Collection. Previous conferences have included
May Sarton at 80 (1992), Sarah Orne Jewett and Her Contemporaries (1996),
and American Women Nature Writers (1998). Founded in 1959 to honor and preserve
the writings of Maine women achieving literary recognition, the Maine Women
Writers Collection is the preeminent collection of published and unpublished
works by and about Maine women writers. The conference program committee
especially welcomes papers based on authors or material found within the
Maine Women Writers Collection.
Those submitting individual proposals should send a one page abstract and
one page c.v. Session proposals should include a description of the session
theme, abstracts for each paper, the name of the session chair, and c.v.s
for each participant. Send proposals, by October 15, 1999 to Elizabeth De Wolfe
at the address below.
For more information on the Maine Women Writers Collection at the University of
New England, contact Roberta Gray ; phone 207-797-7261.


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Claire LaFemmeDC is a Porn Star from Finland. She was born in South West Finland on August 21, 1973. She is listed on FreeOnes since 2007 and is currently ranked 10744th place. She currently has 22 gallery links in her own FreeOnes section.
Our records show that Claire LaFemmeDC is currently active which means she is still making movies, doing live shows and/or doing photo shoots.


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Call our experts: 888.808.FINE
Shop Early & Save 10% on William Arthur, Crane, Vera Wang holiday cards | Code: CELE10 Shop Fall Wedding Invitations Tis the Season! NEW Holiday Greeting Cards Shop Now
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The subnet mask is used to determine which devices are on the local
subnet and which need to be accessed via your default gateway.
If this is a small network and you are not using any other 172.22.x.x
subnets then you will probably be ok, if however, for example, you also
have a 172.22.20.n subnet then you PC's will probably not be able to
reach those devices as the netmask suggests that they can be access
locally without the use of a router which in reality the network
default gateway should be used.
AFAIK if you change the subnetmask on the workstation you are also
going to have to specify an IP address - defeating the idea of DHCP
really... Best to correct the scopy on the server.
geo wrote:
> Windows 2000 server
> I've noticed that clients are getting the wrong subnet mask.
> The scope is set up for 172.22.1.100 to 172.22.1.199
> the subnet mask should have been 255.255.0.0 but it
> was 255.255.255.0
> First question how could having the wrong subnet mask affect
> the network. All the clients are working but I have noticed the
> subnet was wrong.
> Second can you fix the subnet mask in DHCP or do you have
> to redo the scope?
> Thanks,
> George


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Download Guideline Flyer
Submit Your IdeaComplete th form and submit your Ideas
BizIdea Form
Guidelines for the Great BizIdea Showdown*
Why a Great BizIdea Showdown?
Great entrepreneurial ventures start out with a great idea. The UTPA Great BizIdea Showdown is designed to encourage students to come up with a great idea for a business in the hope that the idea will eventually be taken to the marketplace
Prize: $3,000 will be awarded in various categories.
Who: Open to all UTPA students, regardless of major, in groups of 2 to 5 students
When: November 18 - Registration deadline. Register at www.utpa.edu/coba
November 20 - 10am to 1pm - Idea presentations/displays
3pm - announce finalists
4pm - FINALS
Where: Table top displays in BUAD halls, finals in BUAD 110
How: 3'x2' displays and 1-minute oral presentations of ideas
Judging Guidelines: Contest entries will be judged on the following criteria.
Awards and voting:
FinalsThe 5 award winning teams will have 10 minutes to present their ideas to a distinguished panel of judges composed of individuals that are entrepreneurs, that fund entrepreneurial ventures, or that advise entrepreneurs. The judges will ask questions of the team.
Contact for further Information:Dr. John Sargent 665-7137, email@example.com, BUSA 222E
*Contest organizers reserve the right tochange contest rules as appropriate and to disqualify any team that violates these guidelines, or the spirit of the competition.


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Spotlight on Trees
Ancient civilizations used the latex sap from rubber trees to make balls, waterproof clothes and shoes.
Learn more »
Learn about how the Rainforest Alliance is...
3 things you can do to make a difference:
Osmar Monzón: Steward of the Maya Forest
Jaguars, scarlet macaws, howler monkeys and leafcutter ants thrive amidst the dense foliage of the Maya Forest, a biologically-rich ecosystem that extends from Guatemala, through Belize and into Mexico. So perhaps it's no surprise that Osmar Monzón, a fourth-grade teacher at the Ixlú Community School -- located within Guatemala's precious piece of the Maya Forest, in a region known as the Petén -- has developed such a keen interest in protecting his surroundings. "Living and working among the incredible biodiversity we have here, it is difficult not to become interested in conservation," he says.
To ensure that teachers like Monzón have the skills and resources they need to bring environmental education into their classrooms, the Rainforest Alliance provides curricula, hosts workshops in the Petén, Ghana and the US, and offers follow-ups to ensure that teachers effectively integrate our lessons into their classes. "The workshops have increased my knowledge of the region's geography and provided me with new, effective ways to engage children in [conservation] issues," Monzón explains.
His love of the environment is proving to be contagious. "I see some kids telling other to clean up waste when they have littered; a few years ago, this would never have happened," he says.
To learn more about the Rainforest Alliance's work with teachers in Guatemala's Maya Biosphere Reserve, watch a slide show of a recent teacher-training workshop. Interested in bringing lessons in sustainability to schools in your neighborhood? Tell teachers in your community about our Learning Site -- it offers multidisciplinary curricula and resources to help students understand how rainforests contribute to our collective well-being.
More Stewards of the Forest
Spotlight on Trees
Ancient civilizations used the latex sap from rubber trees to make balls, waterproof clothes and shoes.
Learn more »


text:
Accessories Needed
Parts List
Regularly Purchased Together
Easy RC: Cars & Trucks
Browse ARRMA
Product Feature Page
Manufacturer's Product Web Page
Chassis: Composite, with battery door that adds to structural
rigidity and enables driver to change batteries without removing
the vehicle's body, internal channel protects wiring from damage,
alloy TVPs on Arrma's BLX brushless chassis are also compatible
with this chassis and may be added for greater rigidity
Drive: Rear wheel with steel driveshafts and axles
Motor: Arrma 540 size MEGA 15T brushed
Radio: Tactic TTX300 3-channel with user programmable 3rd channel,
steering rate adjustment, steering and throttle trim & end point
adjustments, 3-channel TR326 high voltage (7.4V) micro receiver
with failsafe, 70/30 throttle setting
Steering Servo: Arrma ADS-5 waterproof, 70oz-in (5kg-cm) torque
Electronic Speed Control: 35A Arrma MEGA waterproof, designed to be
used with the supplied NiMH battery
Receiver Box: Water proof and dust proof
Battery: 2000mAh 6-cell 7.2V NiMH with T-connector, chassis accepts
7-cell battery with no modifications
Battery Charger: Wall type charger, charges 7.2V batteries only
Body: Trimmed and printed, black nylon rear wing
Transmission: Lightweight composite
Differential: Metal internal gears
Suspension: Fully independent, screw type hinge pins
Shocks: Composite body, oil-filled
Tires: dBoots Dunerunner with dBoots foam inserts
Front, 1.2" (30mm) wide, 3.3" (85mm) diameter
Rear, 1.6" (40.5mm) wide, 3.3" (85mm) diameter
Wheels: Six spoke, 12mm hex, black in color
Front, 1.1" (29mm) wide, 2.2" (56mm) diameter
Rear, 1.6" (41mm) wide, 2.2" (56mm) diameter
Caster: Non-adjustable caster/toe-in refers to the angle of the front
suspension when viewed from the side of the car in relation to the
Camber: Non-Adjustable, camber refers to the angle of the tops of the
tires from vertical when viewed from front or behind vehicle
Steering: Bellcrank type with servo saver, composite linkages
Warranty: Two year limited warranty beginning at date of purchase
RTR Raider MEGA Baja Buggy with printed Body, 2.4GHz Radio, ESC,
Steering Servo, Brushed Motor, Tires, Wheels, Foam Inserts,
Decals, Instruction Manual, Battery, Charger
AA Batteries: Four for transmitter
Building and track equipment
If needing an aftermarket battery, a 6-7 cell NiMH (7.2-8.4V) with
T-connector is compatible with the stock speed control
Length: 15.75" (400mm)
Width: 10" (253mm)
Height: 5.5" (140mm)
Wheelbase: 11.4" (290mm)
Ride Height: 1.2" (30mm)
Weight: 3.1lbs (1.42kg) without battery
Length: 10.1" (257mm)
Width: 6.2" (157mm) at widest point
Height 2.3" (58mm)
Available in the following colors;
Red/Blue, ARAD35RB
For replacement or to upgrade to ball bearings use:
Qty. Size Location Qty. Bearing Set
4 5x10mm Fr Wheels 2 ARAC3200
4 5x13mm Rear Wheels 2 ARAC3201
2 10x15mm Diff Gear 1 ARAC3202
4 5x10mm Gearbox 2 ARAC3200
jam 11/03/15
updt jxs 04/22/16


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You might've heard WNST is making some major changes. Hope you follow us on our continuing journey…
August 22, 2014 | Nestor Aparicio
You might've heard WNST is making some major changes. Hope you follow us on our continuing journey…
June 11, 2014 | Nestor Aparicio
Thanks for all of the #JennStrong love and support! Here's some new info…
April 25, 2014 | Nestor Aparicio
We need your help! Please become a donor to saves lives via There Goes My Hero at our events with Ravens players
April 04, 2014 | Nestor Aparicio
Need a spring haircut? Here's how you can donate and help us fight leukemia…
December 25, 2013 | Glenn Clark
To celebrate the holiday, Glenn ties a bow on a season of charity from the WNST community…
December 20, 2013 | Glenn Clark
Want some great giveaways and the chance to meet a rock star? We need your coats at WNST!
December 15, 2013 | Glenn Clark
A week of charity, great events, football players and giveaways ahead for the WNST community…
December 06, 2013 | Glenn Clark
WWE Monday Night Raw is coming to Baltimore. If you do some good, Glenn will hook you up with great seats.
November 26, 2013 | Glenn Clark
We took the canned goods to SARC in Bel Air Tuesday. WNST listeners are the absolute best.
November 21, 2013 | Glenn Clark
Make a difference in our community and get some great prizes in the process tonight!


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The City of Miami Beach's Morning All-Stars program is funded by the Children's Trust to serve sixth and seventh graders at Nautilus Middle, Fienberg/Fisher K-8 Center and 21st Street Recreational Center-Teen Club. The program utilizes the evidence-based All-Stars curriculum to deliver thirteen, 45-minute sessions that are designed to prevent, reduce or eliminate negative behaviors and promote positive behaviors. In addition, All-Stars offers a Booster which is delivered in an additional nine supplemental sessions that reinforce the lessons learned previously. Morning All-Stars provides breakfast or a snack as well as transportation to all participants!
For more information, please contact Rita Gangi at 305.673.7491 or check out our program brochure here. For program highlights, check out the Morning All-Stars Photo Gallery or check out our Youtube video. Each week, Morning All-Stars publishes a newsletter containing resource information, program highlights and articles for parents. Click here to sign up!
For more information regarding youth programming, please visit The Children's Trust at http://www.thechildrenstrust.org. The City of Miami Beach Morning All-Stars is funded in part by The Children's Trust. The Children's Trust is a dedicated source of revenue established by voter referendum to improve the lives of children and families in Miami-Dade County.


text:
After 10 months of training, more than 200 AmeriCorps workers graduated at McClellan Field on Tuesday.
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