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Enroll Now!
A new session of each course opens each month, allowing you to enroll whenever your busy schedule permits!
How does it work? Once a session starts, two lessons will be released each week, for the six-week duration of your course. You will have access to all previously released lessons until the course ends.
Keep in mind that the interactive discussion area for each lesson automatically closes 2 weeks after each lesson is released, so you're encouraged to complete each lesson within two weeks of its release.
The Final Exam will be released on the same day as the last lesson. Once the Final Exam has been released, you will have 2 weeks plus 10 days to complete the Final and finish any remaining lessons in your course. No further extensions can be provided beyond these 10 days.
SESR, SERP, PPC . . . do you know these terms? In Lesson 1, you'll learn important search engine terminology. We'll discuss the history of search engines and directories, and you'll learn about the differences between the two. Finally, you'll find out about current major players in the search industry.
How do search engines decide which websites to include in search listings? In Lesson 2, you'll learn how search engines analyze websites and create results pages. You'll also learn how to search for sites that have linked to your website, and we'll discuss some super-savvy search secrets!
You want your website to appear at the top of the SERPs . . . but which keywords will people search for to find your site? In Lesson 3, we'll discuss ways to find potential keywords. You'll begin your research with offline methods, and then you'll use online methods to expand your list. And you'll learn how misspellings can actually help you!
You've created a site-wide list of potential keywords, but which ones should you optimize for? In Lesson 4, you'll learn about the all-important presubmission analysis. You'll determine how often people have searched for certain keywords, and you'll figure out how many other websites are optimized for each of those words. Then, using one simple formula, you'll be able to optimize your site the way the pros do.
It's time to optimize your site! In Lesson 5, you'll learn about HTML tags that you must be intimately familiar with. We'll discuss why page titles and meta tags are important and how you can properly place and construct them. You'll also learn to include keywords in your header, paragraph text, and alt text.
We've talked about attracting people to your site, but how do you keep them interested? In Lesson 6, you'll learn the secrets of creating quality content . . . legally and for free. Also, you'll find out where to place a primary keyword within a Web page, and you'll use keyword density analyzers to determine how often your primary keyword should appear.
Filenames and the technical details of how your website is hosted play a big part in successful search engine optimization. In Lesson 7, you'll learn how to register domain names that lend themselves to top search engine positions. Similarly, we'll discuss filenames and how they can help you. You'll discover the importance of mobile optimization and page speeds. Finally, you'll learn how to responsibly create optimized landing pages.
People often use deceptive techniques to get search engines to list their sites. In this lesson, we'll examine many of these techniques and discuss why you shouldn't use them. You'll learn about keyword overuse, invisible text, and improper comment tag use. We'll also discuss Web page cloaking.
You've optimized your Web pages for top search engine placement, so now it's time to let the crawlers know that they exist. In this lesson, you'll learn how to submit your website to search engines! We'll discuss manually submitting your site to individual engines. We'll also explore multiple submission services, and you'll learn to create and submit XML sitemaps.
It's time to track your progress by completing a post-submission analysis. In Lesson 10, you'll examine the six steps of the SEO cycle. We'll discuss how to find your search engine rankings, and you'll delve into Web server log files and referrer logs. We'll also introduce you to Google Analytics, which can give you vital data—for free—about visitors to your site.
In Lesson 11, we discuss powerful online promotion techniques. You'll learn how quality inbound links can help you. And we'll talk about lots of other ways to promote your site, including newsgroups, question-and-answer sites, email signatures, online advertising, and social media.
Believe it or not, promoting your website offline can make a huge difference in your search engine rankings. In this lesson, you'll learn the importance of affiliate programs and word-of-mouth visits. We'll discuss ways of monitoring your offline promotions, plus we'll talk about "link baiting" techniques that are ethical and that work.


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eeewwww looks ugly (no offence wiired) doesnt matter at least its guna be cheaper and what madcatz brand controller hasnt been ugly?
If they're in the 15-20 dollar price range I'll pick one up.
50 dollars is outrageous for a Nintendo to charge for a controller.
Well do you?
eeewwww looks ugly (no offence wiired) doesnt matter at least its guna be cheaper and what madcatz brand controller hasnt been ugly?
Last edited by Bubbagump; 01-16-2007 at 12:55 PM.
^ Chicago... My kind of town ^SSBB Friend Code - 0602-5991-1331
lol That is what I was thinking.Originally Posted by StevenNevets
Wiichats BIGGER Metal Head
Don't listen to Mr.Resi, Chad Smith owns Thrasher!
Originally Posted by Wii_Smurf
I thought Nintendo copy-righted the Wii-mote. So 3rd party developers couldnt make there own
Wiimote looks slick.
May the Wii be with you
eh dont get third party wiimotes. it just makes them look kiddish.
i hav teh wee! liek zomgz?!232@#112!!
how did you know?Originally Posted by Shiftfallout
I would not buy that; it would eventually disfunction like most of Madcatz accesories
you know eventually 3rd party video game accessory companies would come up with new innovative spins on nintendo wii products right? me personally since the wii is still ever so new and has been known to have a few "hardware issues" (still nothing major though as of yet) i dont think i would trust anything else but official nintendo products IMO. possibly down the line i would consider it but right now? no.
i do say pelican made nice PS2 controllers. i had 2 wireless ones and they worked great never a problem. so who knows about madcatz or wtvr its called....
ill buy the nunchuck
My Lineup:
Nintendo Wii, 3 wiimotes, 1 nunchuck, 1 steering wheel, 1 wiimote grip, 512mb SD Card
Games: Excite Truck, Legend of Zelda: Twilight Princess, Madden 07, Rayman Raving Rabbids, Wii sports, Wii Play
its prob like 2 bucks cheaper
iMac 2.4ghz Aluminum, 4GB iPhone, 12 iPods!

subset: commoncrawl


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A mother orphaned at age 11. A grandfather murdered.
A sensational past, its events shrouded in mystery, only became clear to City Councilman Bob Kellar after an idle conversation turned into a full-blown genealogical search that went back 10 generations.
"I was mesmerized to learn that one of my relatives on my dad's side had participated in an Indian battle during the 1700s, he gave a statement about it in the 1800s," Kellar said. "There were also newspaper clippings of my grandfather's murder. Had my mother been alive to see this information, it would have been incredible to her."
Kellar was one of many who discovered the fascinating leaves and branches of their family tree at the Valencia Family History Center, a free genealogical service provided by the Church of Jesus Christ of the Latter Day Saints.
The center will host a Family History Fair from 9 a.m. to 4 p.m. Saturday, with classes and workshops including scrapbooking, digital photography and British and Scandinavian research.
Since the early 1900s, the church has been actively gathering, preserving and sharing genealogical records worldwide. Resources and services can be accessed online at FamilySearch.org, or through more than 4,500 family history centers in 70 countries, including the Family History Library in Salt Lake City, Utah.
According to Valencia Family History Center director Bonnie Petrovich, genealogy seekers run the gamut.
"Some are intense, some are casual. Some have health issues, for example, adopted people that don't know about their biological parents and want to know if their family history will turn something up," Petrovich said.
"For many, it's just a curiosity about who they are and where they came from."
A 2002 University of Fullerton study by Pamela J. Drake found that the percent of the U.S. population interested in family history increased from 45 percent in 1996 to 60 percent in 2000. More than 70 percent of seekers were female with an average age of 54 years.
To start the search process, seekers should gather as much information as they can about family members, including vital records such as birth, death, marriage and divorce certificates.
In lieu of such records, names, dates and city/county/state information on family members should be collected for further research on Census records.
Seekers should be prepared to spend some time in the search, said Petrovich. "Some people think you can do this in weeks, but the process can often take years. Sometimes you get to the point where, with what info you have, you can't go any further. In the genealogy game, it's called a brick wall."
To get past the brick wall, Petrovich advises thinking outside the box. One seeker insisted that a relative came from Missouri, but an online database revealed a match in Illinois.
After refusing to believe that the relative had moved, the seeker called a cousin, and found out the information was indeed accurate.
"People think they may know the facts, but they might not. It's a process of elimination, of narrowing the field," Petrovich said.
Very often, family roots trace back to foreign countries. Church records in Europe, for example, can date back more than 400 years. Deciphering them can be a challenge, as they often are written in the native language. Petrovich found her bloodlines connecting to villages in Germany and Scotland.
"I was looking at church records from the pre-1700s in old German script. It was a real project. If you only want to go back a couple of generations, it doesn't take long at all, but if you want to dig in and find out about great-grandparents, then that takes some time," Petrovich said.
After finding bloodlines that traced back to the 1600s, Petrovich decided to make the journey to Germany, where she met with a second cousin, as well as a distant relative of a relative that immigrated to the United States in 1853.
"I got to eat meals in their home and take tours of their cities. It was fun. They're a part of my family, I felt connected to them," Petrovich said.
Petrovich felt an even stronger connection upon entering an old German church, where she was allowed to view family records dating back centuries — the doors were opened with an elaborate, almost ancient key, similar to those worn by friars.
As she stood there, Petrovich had a newfound respect for her ancestors.
"I couldn't help feeling an overwhelming amount of love and gratitude for the people that worshipped here, who sacrificed to come to America so I can enjoy the freedoms I have today," she said.
While Kellar hasn't explored the land of his ancestors, he felt compelled to share his history with existing family members, making copies of his genealogy book and sending them to cousins in Oklahoma.
"If you have the opportunity understand your heritage, how can you not look into it? I encourage people to go to the Family History Fair on Saturday, it's a great learning experience," Kellar said.
Santa Clarita Valley Family History Fair, 9 a.m. to 4 p.m. Saturday. Free. Family History Center, 24443 McBean Parkway, Valencia. For registration information, call (661) 296-7625. The Family History Center is open 9 a.m. to 5 p.m. Monday and Wednesday. 6 p.m. to 9 p.m. Tuesday and Thursday and 9 a.m. to 1 p.m. Saturdays. For more information, call (661) 259-1347.


text:
Check out this video of Sean showing off his award from See Doc Run, a cancer fundraiser that gets runners out of their sneakers and into high heels!
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From the Departments of Surgery (Drs Dimick, Consunji, and Lipsett and Ms Swoboda) and Medicine (Drs Pelz and Hendrix), School of Medicine, and the Department of Anesthesia/Critical Care, School of Nursing (Ms Swoboda and Dr Lipsett), The Johns Hopkins University, Baltimore, Md.
Catheter-related bloodstream infection (CRBSI) in critically ill surgical patients with prolonged intensive care unit (ICU) stays is associated with a significant increase in health care resource use.
Prospective cohort study.
Surgical ICU at a large tertiary care center.
Critically ill surgical patients (N = 260) with projected surgical ICU length of stay greater than 3 days.
Central venous catheters were cultured for clinical suspicion of infection.
Main Outcome Measures
Increases in total hospital cost, ICU cost, hospital days, and ICU days attributable to CRBSI were estimated using multiple linear regression after adjusting for demographic factors and severity of illness (APACHE III [Apache Physiology and Chronic Health Evaluation III] score).
The incidence of CRBSI per 1000 catheter-days was 3.6 episodes (95% confidence interval [CI], 2.1-5.8 episodes). Microbiologic isolates were Gram-positive bacteria in 75%, Gram-negative bacteria in 20%, and yeast in 5%. After adjusting for demographic factors and severity of disease, CRBSI was associated with an increase of $56 167 (95% CI, $11 523-$165 735; P = .001) (in 1998 dollars) in total hospital cost, an increase of $71 443 (95% CI, $11 960-$195 628; P<.001) in ICU cost, a 22-day increase in hospital length of stay, and a 20-day increase in ICU length of stay.
For critically ill surgical patients, CRBSI is associated with a profound increase in resource use. Prevention, early diagnosis, and intervention for CRBSI might result in cost savings in this high-risk population.
INFECTION OF intravascular catheters remains an important source of morbidity and mortality for critically ill patients.1- 5 New technology for the diagnosis and prevention of catheter-related bloodstream infection (CRBSI) is rapidly evolving.6 Antimicrobial-coated catheters, ionic silver cuffs, antibiotic-impregnated hubs, and intraluminal antibiotic locks have all been shown6- 10 to reduce the incidence of CRBSI in critically ill patients. However, these prevention strategies are expensive and might increase hospital costs. In the current health care economic climate, the clinical and economic benefit of this new technology must outweigh the increased costs. Population-specific attributable cost estimates for CRBSI will aid in the formal cost-effective analysis of new technology as it becomes available.
Previous studies have estimated the increased length of stay (LOS) and cost associated with CRBSI in a variety of settings. Most studies3- 5 focus on nonsurgical patients, lack appropriate severity of disease adjustment, or include primary and secondary nosocomial bacteremias. Critically ill surgical patients with prolonged intensive care unit (ICU) stays are at high risk for infection. Therefore, they are the most likely to benefit from improved diagnosis and prevention.11,12 This study was conducted to estimate the increased resource use associated with CRBSI specifically for critically ill surgical patients after adjusting for severity of illness.
Patients were enrolled from January 7, 1998, to January 13, 1999, during a randomized clinical trial evaluating the efficacy of fluconazole for the prevention of fungal infections in critically ill surgical patients. Patients in the placebo (n = 130) and fluconazole (n = 130) arms are included in this analysis. The setting was a surgical ICU at a tertiary care medical center. Patients with an expected surgical ICU LOS greater than 3 days were included. Exclusion criteria included pregnancy, age younger than than 18 years, life expectancy less than 24 hours, and receipt of antifungal therapy within 7 days of ICU admission. Projected LOS was determined by a single ICU physician (P.A.L.) based on reason for admission, severity of illness, need for mechanical ventilation, comorbid disease, and hemodynamic instability. The protocol was approved by The Johns Hopkins Hospital Joint Committee on Clinical Investigation, Baltimore, Md. Signed informed consent was obtained for each patient or surrogate before enrollment. Once patients were enrolled, baseline data on relevant patient characteristics were recorded, including age, sex, race, ICU admission diagnosis, surgical procedure, medical comorbidities, and APACHE III (Apache Physiology and Chronic Health Evaluation III) scores. Clinical culture results were prospectively recorded and followed until definitive speciation and sensitivities were available or the specimen was deemed to have no growth.
Catheter colonization was defined as having greater than 15 colony-forming units of microorganisms on semiquantitative culture.13 The definition of CRBSI was the combination of catheter colonization and the same organism in a peripheral venous blood culture within 48 hours of the catheter culture. Diagnosis of CRBSI with coagulase-negative Staphylococcus required 2 positive blood cultures. Catheters were removed and cultured only for clinical suspicion of infection. The intradermal portion of the indwelling catheter was sent to the hospital microbiology laboratory for processing using the semiquantitative roll-plate technique.13
For purposes of billing, each patient hospital admission was assigned a unique identification number. Using this identifier, The Johns Hopkins Hospital discharge database (based on the uniform discharge data set) and the billing database were queried to determine total hospital charges and ICU-specific charges. Total hospital and ICU charges were converted to costs using the hospital-specific ratio of cost to charges during the study. Costs are reported in 1998 dollars. The hospital discharge and billing databases divide charges into several different categories, including total, routine (room and board), operating room, pharmacy, radiology, laboratory, supplies, therapy (physical, occupational, and speech), and other costs.
The Shapiro-Wilks test was applied to test the data for normality. Cost and LOS were not normally distributed and were log transformed for regression analysis. Univariate comparisons were performed with the Fisher exact test, χ2 test, Wilcoxon rank sum test, simple linear regression, or simple logistic regression as appropriate. Severity of illness (APACHE III scores) and demographic data were included in the multivariate analysis if P<.05 in the univariate analysis (Table 1). Multiple logistic regression was used for in-hospital and ICU mortality. Multiple linear regression of log-transformed cost and LOS was performed and the regression coefficient for CRBSI was exponentiated to determine the associated percentage increase in the given variable. In all analyses, P = .05 was considered statistically significant. Analyses were performed using statistical software (Stata 6.0; Stata Corp, College Station, Tex).
During the yearlong study, 1228 patients were admitted to the surgical ICU. Of these, 461 patients were eligible for the study and 260 (56%) were enrolled. The remaining patients were not enrolled because of lack of consent and LOS of 3 days (low risk); misidentification (projected LOS ≤3 days but actual LOS >3 days); or LOS greater than 3 days and lack of consent, age younger than 18 years, or entry into an alternate study. No patient who was projected to stay longer than 3 days died before the third day. Overall, 49% of patients were men, median patient age was 65 years (interquartile range [IQR], 51-74 years), and 73% were white (Table 1). Patients had a high level of critical illness, with a median APACHE III score of 64 (IQR, 51-79). Comorbid disease was also prevalent (Table 1).
The 260 patients in the study each had an average exposure of 18 catheter-days, for a total of 4712 catheter-days. Of enrolled patients, 136 (52%) had at least 1 catheter cultured for suspected infection. The median number of catheter cultures obtained was 2 per patient (IQR, 1-4; range, 1-26). A total of 89 colonized catheters in 54 patients (21%) yielded 120 microbiologic isolates. Colonization was monomicrobial in 73% of catheters and polymicrobial in 27% of catheters. The isolates were Gram-positive bacteria in 80%, Gram-negative bacteria in 15%, and yeast in 5% (Table 2). Eighty-six patients (33%) had at least a single positive blood culture during the study period. There were 17 episodes of CRBSI in 9 patients. The incidence of CRBSI was 3.6 episodes per 1000 catheter-days (95% confidence interval [CI], 2.1-5.8 episodes per 1000 catheter-days). In patients with CRBSI, there were 15 monomicrobial infections and 2 polymicrobial infections, yielding a total of 20 microbiologic isolates. Isolates were Gram-positive bacteria in 75%, Gram-negative bacteria in 20%, and yeast in 5% (Table 2).
Thirty-one patients (12%) died before ICU discharge and 58 (22%) died before hospital discharge. The in-hospital mortality rate for patients with CRBSI was 56% (5/9) compared with 21% (53/251) for those without CRBSI (P = .02) (Table 3). In this population, the difference between crude in-hospital mortality rates (attributable mortality) was 35%. Other univariate predictors of in-hospital mortality were APACHE III score (P<.001), age (P = .04), and immunosuppressive drug use on admission to the ICU (P = .03). In a multivariate analysis, only the APACHE III score remained a significant predictor of mortality (odds ratio [OR], 1.02; 95% CI, 1.04-1.06 per point increase in APACHE III score) (P<.001). However, there was a trend toward increased in-hospital mortality for patients with CRBSI (OR, 4.3; 95% CI, 0.9-19.9; P = .07).
Catheter-related bloodstream infection was associated with an increased risk of ICU death, with 44% mortality in patients with CRBSI vs 11% in patients without CRBSI (P = .01) (Table 3). Other univariate predictors of ICU death were APACHE III score (P<.001), age (P
= .04), unscheduled admission (P = .007), gastrointestinal surgery (P = .003), and history of alcohol abuse (P = .04). In the multivariate analysis, CRBSI was associated with a 6-fold increased risk of ICU death (OR, 6.6; 95% CI, 1.8-24.4; P = .01). APACHE III score also remained a significant predictor of mortality in the multivariate analysis (OR, 1.04; 95% CI, 1.02-1.05 per point increase in APACHE III score) (P = .001).
The median total direct health care cost (excluding professional fees) was $40 722 (IQR, $22 755-$68 587) for patients enrolled in the study. For patients without CRBSI, the median total cost was $40 313 (IQR, $25 327-$67 899) vs $102 965 (IQR, $42 766-$238 698) for patients with CRBSI (P = .02) (Table 3). Comorbid diseases associated with increased cost include cirrhosis (P<.001) and dialysis-dependent renal disease (P = .03). Patients who underwent gastrointestinal surgery also had increased cost (P = .006). In a multivariate analysis, adjusting for severity of illness (APACHE III score) and demographic factors (age, sex, and univariate factors of signifance), CRBSI was associated with a 120% increase in total hospital costs (median, $56 167; 95% CI, $11 523-$165 735; P
= .001). In this analysis, APACHE III score and increasing age were also associated with increased total hospital cost (P<.001 for both) (Table 4). Catheter-related bloodstream infection was associated with increased cost in all categories except for operating room cost and "other" cost (Figure 1). Routine cost (room and board) shows the largest increase between groups ($36 980 with CRBSI vs $13 836 without CRBSI; P<.001).
Total hospital cost for patients with and without catheter-related bloodstream infection (CRBSI) compared across different cost categories. Asterisk indicates P<.05 by Wilcoxon rank sum test.
For all study patients, median ICU cost was $14 859 (IQR, $7416-$35 003). Patients without CRBSI had a median ICU cost of $14 240 (IQR, $7273-$32 734) vs $91 812 (IQR, $21 616-$192 756) for patients with CRBSI (P = .002) (Table 3). Other univariate predictors of increased ICU cost include gastrointestinal surgery (P = .003) and a history of cirrhosis (P = .05). In the multivariate analysis, adjusting for severity of illness and demographic factors, CRBSI was associated with a 300% increase in ICU cost (median, $71 443; 95% CI, $11 960-$195 628; P<.001). In the adjusted analysis, APACHE III score was also associated with increased ICU cost (P<.001) (Table 4). The difference between ICU cost for patients with and without CRBSI divided into cost categories is similar to the findings in total hospital cost. Each cost category demonstrates a statistically significant difference in cost except for other cost, which is a small contributor to overall total ICU cost. Once again, routine cost (room and board) demonstrates the largest difference between the groups ($28 567 with CRBSI vs $5106 without CRBSI; P<.001).
For all patients enrolled, the median hospital LOS was 18 days (IQR, 11-29 days). Patients without CRBSI had a median hospital LOS of 18 days (IQR, 16-20 days) vs 40 days (IQR, 15-165 days) in patients with CRBSI (P<.001) (Table 3). Other univariate predictors included abdominal surgery within the last month (P = .01) and APACHE III score (P
= .005). In a multivariate analysis correcting for severity of disease and demographics, CRBSI was associated with a 124% increase in LOS (22 days; CI, 7-70 days; P = .002). In this analysis, increasing APACHE III score was also associated with increased hospital LOS (P<.001), and there was a trend toward an association of increasing age and hospital LOS (P = .08).
The median length of ICU stay was 7 days (IQR, 3-14 days) for all patients enrolled. For patients without CRBSI, median ICU stay was 7 days (IQR, 6-7 days) compared with 22 days (IQR, 4-111 days) for patients with CRBSI (P<.001) (Table 3). The only other variable with a univariate association was APACHE III score (P = .004). An adjusted multivariate analysis showed a 200% increase in ICU days (20 days; 95% CI, 0.1-58 days; P = .002) associated with CRBSI. Higher APACHE III scores were also associated with increased ICU days in this analysis (P
= .02).
Catheter-related bloodstream infection remains an important cause of morbidity and mortality in critically ill surgical patients. This prospective cohort study estimates the associated increase in cost and LOS associated with CRBSI in a well-defined critically ill population of surgical patients. Patients with CRBSI have increases in total hospital cost of $56 167 and increases in ICU cost of $71 443. Hospital LOS was increased by 22 days and ICU LOS was increased by 20 days. The increase in resource use occurs predominantly in the ICU. Because of the magnitude of resources consumed in this population, efforts at prevention, early diagnosis, and improved therapy are extremely important. Further research concerning the cost-effectiveness of new technology for diagnosis and prevention of central line infections in surgical patients should use this population-specific attributable cost estimate.
The cost and LOS associated with CRBSI in our study are similar to those from previous studies of ICU patients. Pittet and colleagues5 conducted a matched case-control study in a surgical ICU at a large tertiary care center. They reported excess cost of $40 000 (in 1994 dollars) and increased hospital and ICU LOSs of 24 and 8 days, respectively. These values are similar to ours, especially taking into account inflation of medical care costs from 1994 to 1998. However, patients in their study had primary and secondary nosocomial bloodstream infections. Only 20% of patients had bloodstream infection related to an indwelling intravascular catheter. In contrast, the estimate in our study is specific for primary bloodstream infections (CRBSIs) in critically ill surgical patients.
The large attributable cost in our patients is significant across all cost categories except operating room cost. This scenario is plausible because most operating room costs are acquired before ICU stay and the onset of CRBSI. Cost of room and board (routine cost) is the single largest contributor to increased cost in these patients. This finding is consistent with other studies3- 5,14,15 that implicate increased LOS as the dominant contributor to increased cost. In the present study, however, laboratory, supply, and pharmacy costs are also important contributors to overall increased cost. The increase in room cost makes up only approximately half of the estimated attributable cost. Furthermore, we estimated a 22-day increased hospital LOS and a 20-day increased ICU LOS; therefore, most extra days in the hospital were in the ICU setting. This suggests that in a critically ill population with prolonged ICU stay, CRBSI further complicates their underlying disease condition and prevents progression and recovery. All of these consequences will result in prolonged ICU stay and increased cost. The adverse effects of CRBSI will be more pronounced in ICU patients compared with non-ICU patients.
Infection of indwelling vascular catheters occurs from 2 routes. First, endogenous skin flora at the insertion site migrates along the external surface of the catheter and colonizes the intravascular tip. Second, pathogens from hub contamination move along the internal surface of the catheter and colonize the lumen.6 New technology aimed at preventing CRBSI is directed at both of these routes. Appropriate topical antiseptic use coupled with maximal barrier precautions at the time of catheter insertion decreases the rate of catheter infection.16,17 Antimicrobial-impregnated catheters coated on the inside and outside are beneficial at reducing catheter colonization and CRBSI.7- 10 A recent cost-effective analysis concluded that antiseptic-impregnated catheters were efficacious and less expensive compared with standard catheters. The attributable cost estimate used in this cost-effectiveness analysis was determined by multiplying the excess LOS by the per diem costs of hospitalization, yielding a value of approximately $10 000.15 Because in our study population the estimate of increased cost is much higher, these catheters would be cost-effective.
Current diagnostic modalities for catheter-related infection require removal of the catheter, subjecting patients to the risks associated with reinsertion. New methods for diagnosis of catheter-related infections that obviate the need for catheter removal are being developed. For example, the differential time to positivity of paired quantitative blood cultures drawn simultaneously from the catheter hub and peripheral sites has been shown to have 91% specificity and 94% sensitivity.18 In addition, the Gram stain and acridine-orange leukocyte cytopsin test, another rapid-diagnostic technique that does not require catheter removal, has sensitivity of 96% and specificity of 92%.19 However, the cost-effectiveness of these new diagnostic strategies has not been studied.
Estimating the attributable cost of an infectious complication has several limitations. There are 2 study designs commonly used to estimate the cost associated with an infectious complication.20 The first method, used in our study, is a multivariate analysis of a population of patients adjusting for potential confounding variables. The second method is to match patients with the study condition to those without the condition based on age, sex, race, severity of disease, and other variables associated with outcomes. Both of these methods allow for estimation of the increased cost or LOS associated with a certain disease condition. However, the precise contribution to the outcome of interest (cost, LOS, or mortality) cannot directly be determined. Hence, an associative (not causative) relation can be postulated. In a large observational cohort study, Asensio and Torres21 used both methods (matched pairs and multivariate analysis) to determine the excess cost and LOS associated with deep surgical site infections after open heart surgery. They concluded that the multivariate method yields a more accurate estimate of excess resource use attributable to nosocomial infections.21
Another limitation of this study is the small number of infections. There were only 17 episodes of CRBSI in this population during the study. Because of the low number, we have limited power to detect and adjust for all patient characteristics associated with outcomes. However, we were able to adjust for demographics and severity of illness (APACHE III score) in our analysis, which both had a strong association with outcomes. The other univariate predictors had much weaker associations with the outcome variables. Therefore, because we accounted for the most important variables, the additional contribution of other confounders is not likely to contribute much validity to our model.
In conclusion, this study demonstrates a profound increase in health care cost and LOS associated with CRBSI in critically ill surgical patients. The increased cost was incurred in the ICU setting and was mostly due to increased LOS. New technology for prevention, diagnosis, and treatment of catheter-related infections is under continual development and evaluation. Formal cost-effectiveness analyses of strategies to diagnose and prevent CRBSI for surgical patients should use population-specific attributable cost estimates.
Presented at the 20th Annual Meeting of the Surgical Infection Society, Providence, RI, April 27, 2000.
Corresponding author and reprints: Pamela A. Lipsett, MD, Department of Surgery, The Johns Hopkins Hospital, 600 N Wolfe St, Blalock 685/683, Baltimore, MD 21287-4685 (e-mail: firstname.lastname@example.com).
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Marlin 25MN .22WMR info
Tools and Technologies
Rifle Country
> Marlin 25MN .22WMR info
Michigan Trigger
January 1, 2012, 05:26 PM
My mom bought me a used Marlin 25MN rifle for Christmas this year. It's one of the coolest presents she's ever bought for me. :D I was wondering about more info about this rifle from others that own one.
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January 1, 2012, 05:28 PM
What you see is what you get. What type info are you looking for?
Michigan Trigger
January 1, 2012, 05:31 PM
I don't know a lot about this particular rifle. Are they accurate?? Are they made well? I was looking for mostly general info about peoples' experience with this Marlin.
January 1, 2012, 06:17 PM
Had one for quite a while; wish I still had it! Accurate, reliable, light.
Excellent value- you'll like it!
January 1, 2012, 07:34 PM
I've had one for many years, and have shot many sage rats with it. About 1 1/2" groups at 100 yd with the best ammo. Totally reliable. It's a keeper.
January 1, 2012, 07:40 PM
First, let's point out the awesomeness of recieving a gun as a gift-especially when you don't drop 3 months worth of hints! Good job Mom!
I recall my first gun ever was from my mother, and I was so surprised and suuuuper excited. I long for the long thin boxes lurking behind TV consoles or Xmas trees....
I recently purchased a model 20, which is a bolt action .22 LR. It's a Project gun I have been posting about-but a .22 mag seems real nice. Should be a fine rifle for ya!
Michigan Trigger
January 1, 2012, 11:07 PM
I am DELIGHTED that my mom bought me this firearm. I'm ready to buy some ammo and do some plinking with it here later in the week.
January 1, 2012, 11:13 PM
Mine is ammo sensitive. Accurate with any, but POI changes drastically from one to another. I am shooting Hornady V-max loaded by CCI nearly exclusively now. Hits alot harder than you will expect it to.
January 2, 2012, 09:30 AM
I love mine. It's almost a tack driver. I say almost because I have a.22 that's better. There is a very simple trigger job that you do by simply replacing a spring. Check out www.rimfirecentral.com
January 2, 2012, 03:03 PM
I have the Marlin 882 same exact gun just earlier model. Buy several different ammo types and see what shoots the best. To be honest mine likes it all, but it's not used for hunting, just having fun.
January 2, 2012, 03:11 PM
Like others are saying - dig the gift for what it's worth now and try several types of ammo till you find which one this one wants to be fed. I don't remember the particular ammos anymore but mine was accurate enough to be boring with the right ammo and a waste of time and money with others which still fired well in my other rifles. Before reading these responses, I always thought my Marlin was haunted.
January 2, 2012, 05:52 PM
Carbine I read those trigger posts and I am very eager to try the "papermate" spring replacement on my model 20. Thank you for the input!
January 2, 2012, 06:38 PM
I just did that 'Papermate spring replacement' on my Marlin 882 22mag and love it. I was able to cut 100 yd groups from 2-2 1/2" down to a best of about 1 1/8" using Remington 33gr polymer tipped ammo. I didn't have any other ammo with me to try, so who knows it may even do better with a little more work on my part.
January 2, 2012, 08:51 PM
I had the stainless synthetic model and it was an absolute tackdriver with Winchester Power Points. I traded it off and have regretted it ever since. Enjoy it, upgrade the trigger and you'll be set.
January 6, 2012, 03:17 PM
I installed the spring, sort of in a trial for now. My gun is in pieces, being refinished but i suspect I will like this. To see what I am up to:
January 6, 2012, 07:12 PM
Carbine I read those trigger posts and I am very eager to try the "papermate" spring replacement on my model 20. Thank you for the input!
I used a different spring that worked out better for me. If I can the numbers for it I'll post it.
**I found it (part # 1NCG6). I bought it from www.grainger.com. I dropped my trigger down to around 3.5 lbs.**
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China Bowl Asian Cuisine is the newer and more casual sister restaurant of China Boat (above), and it's located in a convenient spot on Honoapiilani Highway in Kaanapali.
"We opened two years ago in September in the Fairway Shops," says Manager Kevin Shao, who is the brother of owner Angela Tay. "There is plenty of parking and we're easy to find."
The locals who work in the resort area make it a regular pit stop for its fast and friendly service. You simply place your orders at the walk-up counter and then relax while you wait on comfortable chairs in the air-conditioned dining room. Visitors and those not working often like to sip a beer while they wait for their to-go orders.
Article Photos
Manager Kevin Shao showcases one of the bottles of exotic wine he pours at China Bowl Asian Cuisine in Kaanapali.
The Maui News / CARLA TRACY photo
"Every day we have lunch specials that include fried rice, steamed white or brown rice or chow mein," says Kevin, from Shanghai. "Everything here is made to order. We feature a Mandarin menu with some Sichuan dishes. But normally our customers request spicy or not."
Some popular appetizers include ribs with salt and pepper, pot stickers, young green soy beans and minced chicken in lettuce wraps. There are plenty of satisfying soups, too, which take the menu out of the Chinese realm. Indulge in saimin, teriyaki chicken ramen, and pork chop udon.
Regulars can't get enough of the orange chicken, Mongolian beef, volcano shrimp, and fish in black bean sauce. Light eaters will appreciate the Chinese salads topped with your choice of chicken, calamari or shrimp. And, the keiki may enjoy knee-high fare such as teriyaki chicken and pork chops that include rice and soft drink. There is a liquor license and a catering menu with half and full pans.
For more details, call China Bowl at 661-0660.


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yay for fridays, it's officially two hours past a semi-normal bedtime and my bed is crying out to me. so keeping short:
B: coffee with 1t of c/o and almond milk, plus about 100g greek yoghurt
L: two boiled eggs, 70g cheddar with lettuce and coriander
D: one boiled egg, 50g cheddar, 100ml whipped cream with 90g berries (I was out all evening and didn't get a chance to make a proper meal)
Sncks: coffee with cream, 20g dark chocolate
Macros: F: 116g/77% C: 14g/6% P: 58g/17% Total Cals: 1410
- missed my greens a bit, but was pleased that managed to hit macros not too badly even when out straight from work - fortunately managed to avoid 'eating out' which helped
- would like to scale down the amount of dairy contributing to the fat percentage a bit, so need to eat more fatty meat, avocados and general oil!
- ate my 'dessert' when I got home, which is definitely too late. Need to work on sleep patterns
Tomorrow is going to be a great day, got an American friend over and we're going to road trip up to a wee place called Dunadd, the coronation spot of kings (footprint in the stone) for a bit of Celtic exploration. I'll let you know how it goes.
Sweet dreams Grokstars


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Maybe this call to caveman instincts helps some. Maybe the change of lockers and a tug-of-war game with a rope in practice helps a smidge, too.
Maybe, as Dolphins quarterback Ryan Tannehill said Wednesday, interim coach Dan Campbell's primal attitude "transcends to the team" in a good sense. Campbell's pushing of desperate buttons and changing the culture sounded like a nice narrative on Wednesday anyhow.
But you know what would sound better on Sunday than all this intangible stuff happening inside the Dolphins in the middle of October?
If there was something tangible backing it up, like Ndamukong Suh playing better or Tannehill being allowed to do something as...


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Doyon, Geneviève; Zerbato, Jennifer; Mellors, John W.; Sluis-Cremer, Nicolas
Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Correspondence to Nicolas Sluis-Cremer, S817 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. Tel: +1 412 648 8457; fax: +1 412 648 8521; e-mail: firstname.lastname@example.com
Received 5 April, 2012
Revised 29 May, 2012
Accepted 15 June, 2012
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.AIDSonline.com).
Objective: Disulfiram (DSF), an inhibitor of acetaldehyde dehydrogenase that is used for the treatment of alcoholism, was shown to reactivate latent HIV-1 expression in a primary cell model of virus latency and is currently being assessed in a clinical trial for its potential to deplete the latent HIV-1 reservoir in patients on combination antiretroviral therapy. The mechanism by which DSF reactivates latent HIV-1 expression, however, is not known and was the focus of this study.
Design/methods: The impact of DSF treatment on HIV-1 latency was assessed in the ACH2, J89GFP and U1 cell line models of HIV-1 latency and in resting CD4+ T cells isolated from HIV-negative donors.
Results: DSF reactivated latent HIV-1 expression in the U1 cell line, but not in the J89GFP or ACH2 cell lines. Interestingly, we found that DSF significantly reduced phosphatase and tensin homolog (PTEN) protein levels in U1 cells and in resting CD4+ T cells from HIV-negative donors. Decreased PTEN resulted in increased phosphorylation of protein kinase B (Akt) and activation of the Akt signaling pathway. Consistent with these finding, pharmacological inhibitors of Akt and nuclear factor-kappaB (NF-κB) block the latent HIV-1-reactivating activity of DSF. Furthermore, we show that HIV-1 expression in the U1 cell line could be activated by a small molecule inhibitor of PTEN or by siRNA knockdown of PTEN expression. Neither the J89GFP nor ACH2 cells express PTEN, explaining the lack of DSF effect on HIV-1 expression in both these cell lines.
Conclusion: DSF reactivates latent HIV-1 expression via the Akt signaling pathway through depletion of PTEN.
Although combination antiretroviral therapy (cART) can efficiently reduce plasma HIV-1 levels in infected individuals to below the limit of detection (<50 copies/ml), it has no impact on the latent reservoir that resides in resting CD4+ T cells [1]. In this reservoir, the integrated provirus remains transcriptionally silent as long as the host cell is in a resting state. However, upon cellular activation, HIV-1 RNA is transcribed and virus is produced, providing a source for recrudescent infection upon cessation of cART. The latent reservoir in resting CD4+ T cells is extremely stable with an estimated half-life of approximately 44 months, which effectively means that more than 60 years of therapy would be required to eliminate it [2,3]. A prevailing hypothesis in the field is that intervention strategies that reactivate latent HIV-1 infection will purge this reservoir by inducing transcription of the latent provirus, thereby causing cells to undergo apoptosis. Ongoing cART will prevent infection of new cells with the net result being reduction in the latent reservoir. Antiviral immune responses may also aid in the clearance of infected cells, and prevent the spread of infection to other cells. With regard to inducing HIV-1 transcription, Xing et al.[4] demonstrated in a primary CD4+ T-cell model that disulfiram (DSF), a United States Food and Drug Administration approved drug used to treat chronic alcoholism, reactivates latent HIV-1 without global T-cell activation. On the basis of this finding, an ongoing clinical trial is determining whether a 2-week course of DSF will reduce the HIV-1 latent reservoir in patients on cART (ClinicalTrials.gov identifier: NCT01286259). Preliminary results from this trial revealed that DSF administration resulted in a small transient increase in viral load in some trial participants that was not statistically significant. Furthermore, a modest 14% decline in the size of the latent reservoir was noted [5]. Despite its evaluation in clinical trials, the mechanism(s) by which DSF reactivates latent HIV-1 expression has not been elucidated. As such, the primary objective of the current study was to address this important knowledge gap.
DSF was obtained from Sigma-Aldrich (St Louis, Missouri, USA). The phosphatase and tensin homolog (PTEN), phospho-Akt and Akt antibodies were obtained from Cell Signaling Technology (Boston, Massachusetts, USA). The β-actin antibody was obtained from Abcam (Cambridge, Massachusetts, USA). The Akt inhibitor VIII, cyclosporine A, SP600125 and Go6983 were purchased from Sigma Aldrich. Potassium bisperoxo (1,10-phenanthroline) oxovanadate [bpV(phen)] and the NF-κB activation inhibitor were acquired from EMD Biosciences (San Diego, California, USA). DNA primers were synthesized by Integrated DNA Technologies (San Diego, California, USA). Cellular proteins were separated using 4–12% SDS-PAGEs from Invitrogen (Grand Island, New York, USA). Immunodetection was performed using the Millipore SNAP i.d. (Billerica, Massachusetts, USA).
ACH2 and U1 cells were obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health (T. Folks, contributor) [6–8]. J89GFP cells were a kind gift from D. Levy [9]. All three cell lines were maintained in RMPI 1640 medium supplemented with 10% fetal bovine serum, 0.3-mg/ml L-glutamine, 100-U/ml penicillin and 100-μg/ml streptomycin at 37°C in humidified air with 5% CO2.
One hundred milliliter of blood was obtained from healthy HIV-negative volunteers. Donation was approved by the University of Pittsburgh Institutional Review Board. Written informed consent was provided for all volunteer donors. Resting CD4+ T cells were isolated from peripheral blood mononuclear cells by magnetic bead selection (Miltenyi Biotech, Cambridge, Massachusetts, USA) as described previously [10].
Small interfering RNAs (siRNAs) targeting PTEN, as well as a control scrambled sequence control siRNA, were purchased from Qiagen (SA Biosciences, Qiagen Inc., Valencia, California, USA). U1 cells were transfected with 80-nmol/l siRNA using the Neon Transfection System from Invitrogen, according to the manufacturer's protocol. The efficiency of gene knockdown was assessed by determining mRNA levels and by western blot analyses of protein expression.
RNA was extracted from cells using the RNeasy Plus RNA extraction kit (Qiagen Inc.) according to the manufacturer's protocol. RNA was quantified using a Nanodrop 2000, and 400 ng of total RNA was used in each reverse transcription (RT) PCR reaction. Amplification was performed using the QuantiTect SYBR Green RT-PCR kit (Qiagen Inc.) and the DNA Engine Opticon system (Bio-Rad Hercules, California, USA). Initiated and elongated HIV-1 transcripts were assessed as described previously [11].
We first assessed the ability of DSF to induce HIV-1 expression in three different cell line models of HIV-1 latency, namely ACH2, J89GFP and U1. The ACH2 and J89GFP cell lines are chronically HIV-1-infected T-lymphocytic cells. ACH2 cells are a subclone of A3.01, which is derived from CEM, a human T-cell line originally isolated from a 4-year-old female with acute lymphoblastic lymphoma, whereas the J89GFP cell line was established from the peripheral blood of a 14-year-old male with T-cell leukemia. By contrast, U1 cells are an HIV-1-infected monocytic cell line, subcloned from the U937 cell line, which was isolated from a pleural effusion of a 2-year-old male with diffuse histiocytic lymphoma. Reactivation of latent HIV-1 expression in each of these cell lines was measured by quantitative assessment of early and late viral RNA transcripts (Fig. 1a; Supplementary Table 1, http://links.lww.com/QAD/A230). DSF was found to reactivate latent HIV-1 RNA expression in the U1 cell line, but not in the ACH2 or J89GFP cell lines. To investigate further this finding, we searched for functional differences in the three cell lines that could potentially account for the differential activity of DSF.
PTEN is a tumor suppressor gene that is frequently mutated in many different cancers. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate (PIP3) in cells and functions as a tumor suppressor by negatively regulating the Akt signaling pathway. The Jurkat T-cell line is PTEN-null [12–14]. Similarly, CEM cells have a deletion in exons 2–5 of the PTEN gene [12] that corresponds to the phosphatase domain and renders the protein unstable [15]. By contrast, PTEN is expressed in the U1 cell line and in resting CD4+ T cells isolated from HIV-negative donors (Fig. 1B).
A prior study showed that DSF led to decreased expression of PTEN and activation of Akt in a dose-dependent and time-dependent manner in human breast cancer cells [16]. Therefore, we assessed whether DSF treatment in both U1 cells and in resting CD4+ T cells impacted PTEN expression and/or activation of Akt. We found that DSF treatment depleted PTEN levels and increased Akt phosphorylation in both cell types (Fig. 1c, d). Interestingly, quantitative PCR analyses revealed that DSF did not impact PTEN expression at the RNA level (data not shown). Furthermore, DSF did not trigger Akt activation in either ACH2 or J89GFP cells, which lack PTEN (Fig. 1e).
To determine whether PTEN depletion and Akt activation contributed to the latent HIV-1 reaction phenotype of DSF in U1 cells, we assessed its activity in combination with inhibitors that targeted Akt or NF-κB (a downstream target of Akt). The Akt inhibitor VIII reduced the activity of DSF in a dose-dependent manner (Fig. 2a). Similarly, the NF-κB activation inhibitor completely negated DSF activity. By contrast, inhibitors of the nuclear factor of activated T cells, protein kinase C (PKC) and the c-Jun N-terminal kinase did not affect DSF activity. Of note, a control experiment was also performed using the PKC agonist prostratin instead of DSF. Consistent with its mechanism of action, the latent reactivation activity of prostratin was only diminished by a PKC inhibitor. To directly determine the role of PTEN in maintaining the HIV-1 latent phenotype in U1 cells, we assessed the ability of a high-affinity PTEN inhibitor [bpV(phen)] [17] to stimulate HIV-1 RNA expression. The bpV(phen) was found to be a potent activator of HIV-1 expression in the U1 cell line (Fig. 2b). Furthermore partial knockdown of PTEN expression by siRNA also resulted in reactivation of latent HIV-1 expression in the U1 cell line (Fig. 2c). Taken together, these data demonstrate that DSF reactivates latent HIV-1 via the Akt signaling pathway through depletion of PTEN. They also provide strong evidence that PTEN is a key regulator of HIV-1 latency.
PTEN dephosphorylates PIP3, resulting in the biphosphate product phosphatidylinositol 4,5-bisphosphate. This dephosphorylation is important because it mediates inhibition of the Akt signaling pathway that controls multiple cellular processes including transcription. In this study, we show that DSF also reactivates latent HIV-1 expression via the Akt signaling pathway through depletion of PTEN. This mechanism is unrelated to the activity of DSF as an inhibitor of aldehyde dehydrogenase, which is the basis for its clinical use to prevent alcohol intake. Of note, prior studies have demonstrated that both histone deacetylase inhibitors [11,18] and hexamethylene bisacetamide [19] reactivate latent HIV-1 through activation of the Akt signaling pathway. In this regard, activated Akt phosphorylates hexamethylene bis-acetamide inducible 1 (HEXIM1), which results in the subsequent release of the active positive transcription elongation factor b (p-TEFb) from its transcriptionally inactive complex with HEXIM1 and the 7SK small nuclear protein. As a result, p-TEFb is recruited to the HIV-1 promoter to stimulate transcription elongation and viral production [19]. Importantly, our findings suggest that PTEN could be targeted to reverse HIV-1 latency. They also suggest that Akt phosphorylation and/or PTEN depletion could serve as a pharmacodynamic marker of DSF activity in vivo. Finally, our research highlights the limitations of studying HIV-1 latency in cell lines. Many of these cell lines were isolated from human cancers and have mutations and/or deletions in genes encoding key enzymes/proteins involved in signal transduction pathways that may play important roles in regulating HIV-1 latency.
There are no conflicts of interest.
Akt; disulfiram; HIV-1; latency; phosphatase and tensin homolog
© 2013 Lippincott Williams & Wilkins, Inc.
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With 27 seconds left in the first half of Game 2 of the Western Conference quarterfinals between the Los Angeles Clippers and Oklahoma City Thunder, the lights at Chesapeake Energy Arena cut out.
Yes, that's correct. The lights went out at an arena named after an energy company. Now, granted, Chesapeake Energy deals with natural gas and oil. But still, it's kinda funny.
After pausing the game for a minute or two, the two teams decided to finish the final 27 seconds of the first half with mood lighting.
Russell Westbrook airballed a 3-pointer at the buzzer. To be fair, he probably would have airballed a 3-pointer in full lighting.
(H/T @CorkGaines)


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Conference on Higher Education : Creating vision and standards. Skopje, The former Yugoslav Republic of Macedonia. 16-17 March 2011
The International Conference titled "Creating Vision and Standards – the Role of Higher Education in Fostering Intercultural Dialogue and Understanding in a Multiethnic Society" is organized by the UNESCO Venice Office in collaboration with the Ss. Cyril and Methodius University in Skopje (UKIM) Faculty of Philosophy and the Organization for Security and Co-operation in Europe -High Commissioner on National Minorities (OSCE HCNM) in the framework of the UN Joint Programme "Enhancing Inter-ethnic Community Dialogue and Collaboration" with the goal to promote cooperation and understanding and to contribute to freedom and democracy, human dignity and solidarity through teaching and learning, research and service.
At no time in human history was the welfare of nations so closely linked to the quality and outreach of their higher education systems and institutions. (World Conference on Higher Education Partners, June 2003).
Given the diversity of cultural communities which is mirrored in its educational institutions, the country serves as a microcosm for exploring issues of intercultural dialogue and understanding. The conference will bring together higher educational leaders, scholars and students to discuss how higher education today contributes or could contribute to creating a culture of dialogue at the institutional, local, regional and international levels. The Conference will explore and offer a forum for sharing ideas, examples of good practice as well as innovative ways by which higher education can foster dialogue and understanding in the context of diversity in a 21st Century society.
The Conference will address two main topics: Day 1. Exploring the Multifaceted role of Institution of Higher Education (IHE) in a multiethnic society and Day 2. Discussing the content of integrated education – selected challenges.
It aims to initiate debate on the role of higher education in the implementation of this Strategy and fostering inter-cultural dialogue and understanding in the education system and processes of the country. By involving multiple partners from public and private higher-education institutions, with local and international experts, the Conference aims to also improve dialogue and cooperation amongst diverse education stakeholders, identifying common objectives, priorities and challenges for intercultural dialogue and cooperation.
The focus of the discussions will be on recognizing one's own roles and responsibilities and finding solutions to challenges in the process of fulfilling higher educations' mission in a 21st Century multiethnic society like this one. The report from the conference discussions will be used as a basis for needs assessment analysis and identification of key priorities for action of the relevant institutions. Human rights being one of the issues this conference aims to tackle, this project will also contribute to the UN World Programme for Human Rights Education.
Links :
UNESCO Higher Education
University UKIM http://www.ukim.edu.mk/en_index.php
Faculty of Philosophy http://www.fzf.ukim.edu.mk/index.php?lang=en-GB
OSCE HCNM http://www.osce.org/hcnm
<- Back to: UNESCO Office in Venice


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Best and Worst of the 2014 Academy Awards
Ups and downs on the telecast, as always
Worst: John Travolta introducing Idina Menzel
Idina Menzel is a Broadway superstar, but in introducing her (for her performance of "Let It Go") John Travolta reduced her to what sounded like a sneeze or an off-the-menu dish at your local Indian restaurant. In the history of mangling names, Travolta's mispronunciation is right up there. He left out entire syllables, as if his tongue was simply exhausted by the unusualness of it all. I'm thinking someone left his readers at home because he didn't want all of us to know he's getting older, but this would be a time when vanity shouldn't have outweighed good manners. Luckily Ellen Degeneres made a point of thanking Menzel at the end of her performance. A few people have pointed out Menzel didn't hit all her notes, which is hard to believe, but possibly being called words that might be insults in the right language didn't help.
- Liane Bonin Starr


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Older Men, Younger Women
The May-December story continued...
"The concept of what age means in our society is changing very rapidly," says Ian Alger, MD, clinical professor of psychiatry at Weill Medical College of Cornell University. With many men rejecting the idea that they should retire at age 65, older men are discovering they feel vigorous enough to mate and even to start new families, he says. The Internet has been a rich meeting ground, since it lets people communicate without revealing their ages. "It brings everybody into the marketplace of life," he says.
Sometimes, people aren't even looking for the right partner online; it just happens. When Tamara Latorre first started chatting online with her now-boyfriend, she says she paid no attention to age. "I had absolutely no expectations of meeting him."
The challenge of May-December
While these pairings can bring great joy, they often carry unique challenges, experts say. First among them is that the average life expectancy for men is now 73.6 years, according to the National Center for Health Statistics, compared to a life expectancy for women of 79.4 years. An age difference of 15 or 20 or 35 years early in life may seem insignificant, but over time the age gap can mean that the younger woman is nursing an ill or dying husband just when she's in midlife and eager to be active. "We're dealing with two people in different stages of the life cycle," says Harvey Rubin, MD, clinical professor of psychiatry and director of continuing education at the Yale School of Medicine.
Trying to merge these cycles may involve reconciling to the fact that the woman will be left to raise a child by herself. One couple Rubin saw in private practice met when she was in her early 20s and he was in his late 50s, a dashing and successful businessman and musician. "She promised him she'd never want children," reports Rubin. "Well, he became a father at 82." Because of heart trouble, he's not able to help much with the child, who is now 3. "Their marital relationship is really nil," says Rubin. "He's been ill and needs her help."


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Created in this Craftsy class
Plus-size women deserve cute clothes! Learn how to make comfortable and flattering garments with Barbara Deckert, author of Sewing for Plus Sizes.
Other projects made as part of this class:
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
What materials did you use? I used Crepe de Chine which is probably not the easiest fabric to sew but it was what I had in my stash and I wanted to practice sewing with slippery fabric. Pattern was Vogue 8815 which came with the class.
What are you most proud of? That I finished this top and it's wearable, I installed an invisible zipper, made my own bias tape to finish the neckline.
What advice would you give someone starting this project? Watch all of Barbara's videos and then sew along with Barbara at each step and you'll end up with a top that fits you well... oh and probably don't use a slippery fabric like I did for your first attempt... other than that just jump in and have a go... you might just surprise yourself how well your top will turn out :)
forgot to add - am considering joining - I like the idea of having a dress form for my weird shape
I'm sure you'll love this class and all the tips Barbara shares with us... enjoy :)
you look beautiful. so, are you making about 20 more of these?
Thanks Kathy and I have to admit I love this top and it's all thanks to Barbara's class! I'd love to make lots more of them as well. I've made so many clothes since this top and each time I've managed to get the perfect fit from what Barbara shared with us. I hope you enjoy this class as much as I did :)
Wow That looks great.
Thank you :)
Beautiful! How did you draft the change to the neckline? Very flattering.
I just find a curve along my French Curve ruler that I think will look nice and marked out the new neckline shape. (sorry I didn't reply sooner but I didn't know you had left a comment. Much better now that we get Craftsy notifications when someone leaves a comment :)
I am making this top but even though I added 2 inches to the original peplum it is still too short to me. How can I add a second peplum? I saw a picture of this but she had no instructions how she did it
You could just cut out another peplum adding in the additional length you want and then attach it along the same seam where you attached the original peplum and you would then have a double layer peplum. Hope this helps :)


text:
An interview with the chairman of the Massachusetts Gaming Commission, Stephen Crosby
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(based on 29 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Most Liked Positive Review
A pleasure to use
This pen is attractive and makes writing a breeze. I ordered the fine nib and find it "fine." That is, I like it! It is not too dense. Nor...Read complete review
This pen is attractive and makes writing a breeze. I ordered the fine nib and find it "fine." That is, I like it! It is not too dense. Nor do I think the barrel is too large. It is quite comfortable to hold and use, and writes smoothly. The copper color looks more orange, which is what I was hoping for as the colors of the school for which I work are black and orange.
Most Liked Negative Review
Ouch, it hurts!
What a surprise and a disappointment! This pen is not round where you hold it. It has curves with ridges between the curves. and is very uncomfortable for me to hold. I am...Read complete review
What a surprise and a disappointment! This pen is not round where you hold it. It has curves with ridges between the curves. and is very uncomfortable for me to hold. I am sending it back and trying something else!
Reviewed by 29 customers
Displaying reviews 1-10
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Great Everyday Fountain Pen!
By CPT694
from Ohio
Comments about Lamy AL-Star Fountain Pen:
I wanted a fountain pen that I could use every day at work and leave it there when I go home. This pen fits that bill perfectly. I bought the extra fine and it definitely writes extra fine. Love that! It is a very light weight pen, which I usually like a pen with more weight, but the looks and function of this pen more than compensate for it being lighter in heft.
Bottom Line Yes, I would recommend this to a friend
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Very pleased with the AL-Star.
By AJC
from St Thomas, Ontario, CANADA
Great pen. Well balanced, fits my hand nicely, smooth fine flow of ink.
Lamy All Star Fountain Pen
By Loyal Levenger Customer
from Central, Texas
I have only had these two pens (One for blue ink and one for black ink) a week and I love everything about them. I like the finger grip. The "sharp ridges" one reviewer complained about is easily taken care of with a pen knife. How about that! Someone that still owns a pen knife! I once owned a high end fountain pen that was stolen by some unscrupulous house painters. Lesson learned! So, I have not had a fountain pen for a couple of years. I cannot believe how much I missed writing with a quality fountain pen. The craftsmanship and nominal cost compared to all the other pens in the catalog I have been dreaming about is great. I plan on purchasing a new replacement of my stolen high- end fountain pen in the near future. In the meantime these pens will suffice for now in my everyday note taking and thank you and greeting card writing. I plan on purchasing a another Lamy Al Star Fountain Pen and gifting it to a friend to address her wedding invitations. I have been a long term customer and this is my first time to review a product. That is how impressed I am with these pens.
By Andrea
from Bend OR
Bottom Line No, I would not recommend this to a friend
Merchant response: Thank you for sharing your feedback on the Lamy AL-Star Fountain Pen. We apologize that it has not exceeded your expectations. We have forwarded your comments to our quality assurance team. We pride ourselves on providing exceptional customer service, and the complete satisfaction of our customer is important to us. You will be contacted shortly by one of our customer service representatives to discuss options to resolve this matter.
A stylish workhorse
By Pastor Sean
from Grand Rapids, MI
I have purchased several pens from Levenger over the years. I've never been disappointed. The Lamy Safari is no exception. I had my doubts as it is one of the least expensive pens I own, but in this case, you get MORE than you pay for! Great style, great function. Smooth writer, interchangeable nib, great quality.
(2 of 2 customers found this review helpful)
Great pen
By The Librarian
from State College, PA
Wonderful pen, good balance, smooth writing. Great everyday pen. The only problem was with the sticky bar code label that was on the pen itself. After peeling it off it left a very sticky residue. I contacted customer service to see if they could suggest how to clean it off. No good suggestions but she did offer to send another pen. Second pen also had the sticky label. After some trial and error I figured out Goo-Gone was the best way to clean it up and not harm the finish. So if you buy this great pen make sure you have some Goo-Gone on hand.
(1 of 1 customers found this review helpful)
My Favorite Pen
By LarryB
from Goldendale, WA
This pen was writing amazingly well within seconds of removing it from the box and installing the ink cartridge. I've only used it for about 3 weeks but it has become my favorite pen. I ordered the extra fine nib and it is perfect. (Now if we could only get Levenger to make fine point nibs I would be in heaven. Their "fine" point nib is in no way a "fine" point nib. I've ordered several "True Writer" pens with the "fine" point nib thinking this will be the time. < sigh> Nope not this time. So I must be insane because I keep ordering the same pen expecting different results. :-) But, I digress.) Lamy simply makes a great pen. You can't go wrong with a Lamy fountain pen. Levenger service, as always, was impeccable. My order arrived a day earlier than predicted. I ordered other items at the same time. They were all packaged well with no damage to anything. Of course, the actual Levenger products (Stanley Journal, refills and various Circa items) were of the highest quality. The Stanley Journal is so nice I'm almost afraid to use it. Almost. I've never been dissatisfied with any Levenger product over the years. I wish I could afford more! (Now, if we could just get those "fine" point nibs.... )
Love this pen.
By Deedee
from Gadsden, Alabama
I have 34 of these fountain pens, and I love them. I have an extensive list of people I write lettersand cards to, and I also addressed all of my Christmas cards with my new pen. My Lamy's have a finepoint, and I don't find the barrel hard to hold at all. It writes smoothly and is a great value, the quality isamazing. It would make a great gift for someone who loves to write as I do. I handle the greeting cardministry at our church and everyone has noticed I use a fountain pen and commented on how neat itwrites.
By Bip
from Atlanta, GA
Images shared by Bip
Loving the pen!
Great everyday fountain pen
By PenIt
from Florida
I have been wanting a fountain pen for awhile now and decided to go with the Lamy Alstar partly because of the reviews and also because of the inexpensive price compared to most fountain pens. I find the fine point to be perfect for me but the size of the barrel is a bit oversize for me and the pen becomes somewhat heavy and unwieldy when the cap is placed on top. The ink flows readily and the blue-black color is just what I expected. I will use the Lamy as my everyday pen but I really need to find a slimmer model fountain pen.
© Copyright Levenger Company
2016. All Rights Reserved.


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CBNNews.com - EILAT, Israel - The bus crash Tuesday, which killed 25 Russian tourists and injured 33 people, 23 seriously, was the deadliest traffic accident in Israel's history.
Most of the bus's 60 passengers were travel agents from five tour agencies in St. Petersburg, who came for business as well as vacation.
The bus was transporting the travelers, who had just landed at Ovda Airport, to Israel's southernmost resort city of Eilat, a popular winter vacation spot for Russians.
The driver, Edward Gelfond, 39, hospitalized in serious condition, has a record of 22 traffic citations in his 20-year driving history. He has a valid commercial driver's license.
According to eyewitnesses, Gelfond had passed one bus at recklessly high speed and was preparing to pass another when the bus veered off the road, plunging down a 45-foot embankment.
From his hospital bed, the driver said something fell on him, causing him to lose control on the steep, winding road to Eilat, which is heavily marked by caution signs.
According to Israel's Channel 2, Gelfond said he had not exceeded the 70 kilometers per hour (43.5 mph) speed limit.
The fatalities and most serious injuries were to passengers flung out of the careening bus, while those who were still in the bus were somewhat better off.
On Tuesday evening, Israeli President Shimon Peres told Russian President Dmitry Medvedev that Israelis feel "as if this tragedy happened to us."
"The pain is felt by all of Israel," Peres told the Russian president.
Outgoing Prime Minister Ehud Olmert, in London at the time of the accident, added his condolences, calling the accident "unusual in its severity."
Foreign Minister Tzipi Livni also spoke with Russian Foreign Minister Sergey Lavrov.
Meanwhile, police said remarks by Transportation Minister Shaul Mofaz -- that the accident resulted from an argument between two bus drivers -- were premature. Mofaz also criticized the leniency in the court system with traffic offenders.
"There was no dispute," said Rami Vazana, the driver of the bus that was passed, who recounted the events that preceded the accident.
"He [Gelfond] was in front of me in the beginning," Vazana said. "When we reached the Netafim roadblock, he was held up. One of the soldiers boarded the bus…and gave me the go-ahead first. I began to drive down the descending road slowly and carefully, as you should," he said.
"Meanwhile, the bus behind me tried to overtake me. But the road began to bend, and he couldn't make the turn. He crashed into the safety barrier and plunged down the cliff. I stopped the bus and three of us went down, carrying bottles of water. It was a terrible sight. We left the water bottles there and went back up to the buses because our passengers were in a terrible panic and wanted me to take them to their hotels. We took them to their hotels and that was that," he said.
Tuesday's tragic accident goes on record for the highest death toll in Israel's history. In 1985, 18 children and two adults died when a train hit a bus stalled on a track, while 1999, 16 people were killed in a bus accident in the north.
Sources: Haaretz, The Jerusalem Post
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The Terrorists Funded by the WestBassam Tawil
The New Israel Fund and those who support it are helping terroristsRonn Torossian
Column one: Fighting fire with fireCaroline B. Glick
Op-Ed: There is no 'radical Islam' and there is no 'moderate Islam'Dr. Mordechai Kedar
'Narrow' escapesRuthie Blum
Why Palestinians Do Not Want Cameras on the Temple MountKhaled Abu Toameh
Social Media Killed My FatherYoni Kempinski and Ari Soffer
Iran's New Palestinian Terror Group: Al SabireenKhaled Abu Toameh


text:
Peta Murgatroyd is a former Dancing with the Stars champion, winning the coveted mirror-ball trophy in season 14 – only her second season on the series – with Donald Driver. The Australia native will be blogging for PEOPLE.com about competing with Gilles Marini in the current all-star season.
Our group "Gangnam Style" dance was the highlight for all of us last week. It was ridiculous. Maks [Chmerkovskiy] was in charge of most of it. We had two big group rehearsals, and for the rest of it, we worked around our schedules on our own time. We had to come up with the concepts, but Maks gave us the towel theme.
Maks and I love working together. It's so rare that we get to do it because we're always one-on-one with our celebrities. So, when we do get to work together, it's fun, and it's nice to get creative.
Kirstie [Alley] and Maks have such a kooky relationship. Kirstie is crazy, and Maks and I both love her dearly. She brings this funny, humorous, warm side out of Maks that I know, but on the show, not everyone else necessarily does. I'm glad people can see it. She's such a comedian. When we're with her, we're constantly laughing. Everyone has such a good time with her, and she doesn't take anything too seriously.
This week is country week. Gilles [Marini] and I are dancing to Shania Twain's "Man, I Feel Like a Woman," which is an amazing, catchy song to have. We're doing a cha cha. We've had a hectic week because Gilles is back to filming [ABC Family's] Switched at Birth. It's been long hours.
Gilles has so much talent and so much dedication to the show, but I've been surprised with our amazing scores these last two weeks. I wasn't expecting 10s for the Bollywood routine. I think his acting skills have really come into play, and we work really well as a dancing couple. These dances have shown our chemistry.
I'm okay with staying at this level of difficulty for now. We're just over the halfway point of the competition, and if we continue to stay this way, with two 10s and a nine through the finals, then I will be very happy and satisfied. If we get three 10s in the finals, then that's the best time to peak.
I don't think anyone's dance has been deserving of three 10s so far this season. I think it's way too early for that. I don't think the judges are going to bring out three 10s until the semi-finals.
TV Watch Only on People.com
Peta Murgatroyd Blogs: 'Maks and I Love Working Together!'
Craig Sjodin/ABC


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#110 - winniedawho
Reply +1(07/04/2012) [-]
can someone give me a link where I could watch all of the series without signing in and for free? I've watched Dr. Who only from a pirated dvd , only up to the part when the bitchy girl was on a trapped on a parallel world forever.
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Lloyd Boston: Spring solutions are in your closet
[caption id="attachment_26187" align="alignright" width="300" caption="Lloyd Boston / Courtesy of Macy's"][/caption]
From his show on HGTV to guest appearances on the "Today Show," "Oprah" or "The View," Lloyd Boston's audience is typically the entire country.
On Saturday, it will be the women of Orange County.
Boston, who splits his time between New York and Los Angeles, is now on a tour representing Jones New York. He'll host a fashion presentation called "How to Wear It" and meet with local fans at Macy's at South Coast Plaza.
The fashion expert shared his philosophy on trends and styling real women.
Q. What do you like most about this spring season?
A. I'm really excited this season about finding a mix of strong silhouettes, like military and that gorgeous safari jacket -- strong, structured things. I'm glad to see them come back.
But I'm also seeing those same structured garments with soft, traditional feminine florals, geometric patterns and easy animal prints that are actually wearable. I love the mix of the structure and the sweet.
Q. Are there specific trends or pieces that you're encouraging?
A. Three things really speak to me. First, bold color. You got to have a piece of bold color in your wardrobe. It's the best way to wake up a closet full of neutrals.
The second thing is knit dressing. Knits don't necessarily have to be your top. They can be your skirt or pants.
They pack really well. You can layer them without adding a lot of bulk. If a woman looks like she packed a steamer trunk but has a carry on, she probably has knits.
Knit separates is a great way to go for spring, especially in California with the weather.
Lastly are clothes that have a touch of modern metallic, not clothes that are overly shiny or rock-star shiny but beautiful suits that have a bit of sheen to the finish.
Maybe it's a woven tan jacket that has a little bit of shine in the fabric. It's an ageless way to add youth to your closet.
Q. Do you have any warnings about how not to wear those trends?
A. I don't point out what women are doing wrong. They have enough pressure. What I will say is many women have a tendency to overlook the source of their style, which is really their closet.
They think it's about the trend of the moment. The source is where you house your clothes and accessories. How do you feel when you open those doors? Your closet is really an important part of your day-to-day image.
Q. You do a show called "Closet Cases" on HGTV. What's the way to manage a closet?
A. The solution to that is, you only keep your greatest hits in your closet. You only keep the things that give you compliments. A trusted friend can help you in that editing process.
You have to take everything out at least once a year and only put back in what you absolutely love.
What I love about the show is I get to go into the homes of real women to see what makes them comfortable and what holds them back.
Q. What's your philosophy in terms of talking about style with real women?
A. I never critique women. I never say, "Wow, get rid of those." My job is to show a women what she's doing right and how to do more of the same.
If a women loves sweatsuits, I'm going to show her how to find the most stylish sweatsuit out there. I'm not going to take a woman who wears khaki and sweatshirts and put her in an evening gown. She's not going to feel comfortable.
There's a culture out there where being critical and negative on style has been popular on TV. But it never makes me feel good at the end of the day. I want to be more of a BFF to women.
Q. What are similarities and differences you see among people across the country?
A. In general, people these days want comfortable options that can still be seen as stylish. Women can be cute and comfortable, and guys can be stately and comfortable.
There are some universal truths when it comes to speaking to women nationwide. But I've been touring for over 10 years. You get a real look at what American women wear in different parts of the country.
Most women think I'm coming to teach them, but they're really teaching me.
It's a fun challenge for me. I don't dress celebrities. I get a great challenge out of dressing real women who have real bodies, real lifestyles and real budgets.
Q. What do you expect to see in Orange County?
A. I know about the stigma that's become attached to Orange County because of the Bravo show. A lot of women don't like the message that's being sent out. I'm hoping to meet the un-Housewives of OC, who want to embrace a modern wearable style that can be fun for certain evenings and that can also be timeless, fun and practical.
I don't expect women to come to this show dolled up, looking for their red carpet moment. I expect to meet women who have loved Jones New York for many years.
Q. Tell me about the event you're doing here on Saturday.
A. I'm looking forward to doing a fashion show that's also a party. There are refreshments. There's a live makeover. I'll take a woman at random and for 20 minutes, she's backstage getting a Lloyd Boston Jones New York makeover and she's in the finale.
And I hit the shopping floor with the ladies. We do 5-minute appointments, it's like speed dating.
Q. Do you choose all the looks that they'll see in the presentation?
A. I bless every outfit that hits the runway.
Q. How did you get started in this business?
A. I spent 10 years on Seventh Avenue in New York working for a designer. But I left the Seventh Avenue world to start writing books about fashion. My fourth is coming this September. It's called "The Style Checklist."
Q. Who in the public eye do you think dresses well?
A. I think when it comes down to ageless style, I love people like Susan Sarandon and Diane Keaton. I think they have looked great for decades. They have embraced their body and their age.
Among contemporary women, Michelle Obama has empowered women to mix high and low, designer and affordable clothes. She's shown how to focus on your waist once again.
Women like Drew Barrymore and Sandra Bullock, on the red carpet or off, they always look believably stylish. They know how to amp it up for the red carpet, and off, they look modern, with natural makeup.
Women who try to look glam every day absolutely wear themselves down. I love relaxed elegance.
More Spring 2010:
[rssfeedme cat="stylebinge" feedpath="/tag/spring-2010/feed/" max="10"]
Style Binge's take on "How to Wear It":
[rssfeedme cat="stylebinge" feedpath="/category/how-to-wear-it/feed/" max="10"]
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Free Shipping Day: The Biggest Cyber Holiday You've Never Heard Of!
People procrastinate. You might even be procrastinating right now by reading this. So how does this affect you as an online retailer? As everyone knows, Black Friday and Cyber Monday are the marquee holiday shopping days of the year. But what about all those consumers who didn't get such an early start or maybe have been struggling to find the perfect gift for a few remaining family members or friends? Wherever there's a 'what about…?", there's an opportunity and that opportunity is one of the busiest two or three online shopping days of the year: Free Shipping Day. So what exactly is this all about? Free Shipping Day is a one-day online shopping event when thousands of merchants offer free shipping with guaranteed delivery by Christmas Eve. What started out as a year round Free Shipping site that guided customers to merchants with such a promotion, has rapidly turned into a simple, yet effective way for online retailers to extend their holiday season on a specific day leading up to Christmas. This year Free Shipping Day is Monday, December 17th.
In a few short years, Free Shipping Day has taken off dramatically, culminating last year when it drove $1 billion in online sales, making it the highest earning Friday in the history of online retail. FreeShippingDay.com makes it easy for customers to navigate among participating retailers by industry type as well as sort alphabetically. To make it even more user-friendly this year, the site is now mobile optimized. If a free shipping promotion is right for your business this holiday season, then FreeShippingDay.com might be the spotlight you're looking for. To participate, or for more details on Free Shipping Day on this free service, visit: http://www.freeshippingday.com/merchant-sign-up/
*To qualify, Nexternal clients can offer the peace of mind of on-time delivery by turning on the Preferred Delivery Date feature in Settings/Site Options/Expected Fulfillment which enables users to specify their ideal date of package arrival.


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PHILADELPHIA Former Gov. Ed Rendell and his wife, Judge Marjorie O. Rendell, are launching a program with Arcadia University and the National Constitution Center to boost citizen engagement in the democratic process - in part by getting young people interested early.
At a morning news conference at the Constitution Center, the Rendells announced the formation of the Rendell Center for Citizenship and Civics at Arcadia.
Ed Rendell cited a poll conducted before the Constitution Center opened in 2003 that he said showed "high school students were remarkably uninformed about our system of government."
He also said he had long believed one of the biggest challenges facing the nation "is lack of citizen engagement and participation."


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Many of you have caught on to the little in-joke I started about 20 comics ago. If you haven't…well too bad. I'm not going to say what it is.
This one is my favorite.
Mirror gag's a nice touch.
Probably the most terrifying thing I've ever seen
Should have had him show up in the neighbor's bathroom. Interception!
Best comment ever.
For a second I thought you were summoning him to the top of our roster, you devious bastard.
This is beautiful you magnificent bastard.
It's Rax Grissman!
Alright, I lost my shit on this comic. I mean, absolute hysterical laughter.
I approve of this. I can see Rexy as a superhero for some reason.
I like to imagine the red-haired kid is Andy Dalton, because it gives me ideas for a crazy backstory of football magic and wizardry and BOOM Tough-actin Tinactin!
How did I get so off! I just assumed Sexy Rexy has been Rex Ryan for months… which given his stature seems funny (rhyme aside). Oh for shame on me.
I thought the same, because I call Rex the SEX CANNON exclusively.
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