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adaptive clinical trials:
The demand to
accelerate drug development while reducing health care costs encourages
companies to seek innovative, more efficacious solutions. There is a
realization that adaptive designs for clinical trials have the potential
to accelerate every phase of drug development. An adaptive design means
that the dosing, eligibility criteria, sample size, or treatment
settings can be adjusted during the course of the trial as evidence
accumulates. The final goal of adaptive clinical trials is to bring
technological advances to patients in the most efficient manner.
Nevertheless, an adaptive clinical trial should not become an end in
itself. An array of questions should be addressed during the planning
stage of a trial. Is an adaptive design appropriate for a particular
study? What are the regulatory requirements for adaptive design? How to
build in and then manage an adaption? How will it impact data analysis. Adaptive
Clinical Trials
The pharma industry is gradually coming to realize that the classically structured clinical trial does not offer enough flexibility to make use of continuously emerging knowledge that is generated as the trial progresses. Unacceptable levels of attrition in the clinical stage of development are driving profound changes in the architecture, design, and analysis of clinical trials. The majority of respondents to our survey said that reduction in patient numbers, less exposure to study drug, and drops in overall trial duration were key points in favor of adaptive designs; however, a majority also had specific concerns with adaptive trials―concerns that involved methodological, logistical, and regulatory uncertainties: Herman Mucke, Adaptive Clinical Trials: Innovations in clinical trial design, management and analysis, Insight Pharma Reports
Clinical trials webcast Jerald Schindler, VP Biostatistics and Research
Decision Sciences Late Stage Clinical Statistics, Merck Research
Laboratories http://www.bio-itworld.com/webcasts/lsw/schindler.aspx
Bayesian clinical trials: In recent years, there has been an explosion in predictive technologies to help researchers select only the most promising candidates for clinical development. The need for such tools is driven by the disastrous economic consequences of late-stage failures, which account for over 60% of all drug terminations. Insight Pharma Reports, Bayesian Forecasting of Phase III Outcomes: The Next Wave in Predictive Tools, 2007
Bayesian network:
Wikipedia http://en.wikipedia.org/wiki/Bayesian_network
Bayesian statistics:
Bayesian statistics is an approach for learning from
evidence as it accumulates. In clinical trials, traditional (frequentist)
statistical methods may use information from previous studies only at the design
stage. Then, at the data analysis stage, the information from these studies is
considered as a complement to, but not part of, the formal analysis. In
contrast, the Bayesian approach uses Bayes' Theorem to formally combine prior
information with current information on a quantity of interest. The Bayesian
idea is to consider the prior information and the trial results as part of a
continual data stream, in which inferences are being updated each time new data
become available.
this document we will use the terms "prior distribution", "prior
probabilities", or simply "prior" to refer to the mathematical entity (the probability
distribution) that is used in these Bayesian calculations. The term
"prior information" refers to the set of all information that may be used to
construct the prior distribution. FDA, CBER, CDHR Guidance for the use of
Bayesian Statistics in Medical Device Clinical Trials Feb. 2010 http://www.fda.gov/medicaldevices/deviceregulationandguidance/guidancedocuments/ucm071072.htm#1
biomathematics: The application of mathematics to problems in biology and medicine. An essential tool in fields such as population genetics, cellular neurobiology, comparative genetics, biomedical imaging, pharmacokinetics, and epidemiology. It plays an increasingly vital role in the effort to understand diseases and disorders, and to improve therapies. Collection Development Manual, National Library of Medicine, US 2004 http://www.nlm.nih.gov/tsd/acquisitions/cdm/subjects14.html Related terms: bioinformatics, computational biology
big data:
informatics: "the field
that is concerned with the optimal use of information, often aided by the use of
technology and people, to improve individual health, health care, public health,
and biomedical research"1. William Hersh 2010 , Biomedical
Informatics, Ohio State University http://medicine.osu.edu/bmi/Pages/index.aspx
biomedical ontologies: Open Biomedical Ontologies is an umbrella web
address for well-structured controlled vocabularies for shared use across
different biological and medical domains. http://obo.sourceforge.net/
Biomedical Ontologies:
ontology recommender web services: http://www.bioontology.org/wiki/index.php/Ontology_Recommender_Web_service
BIRN Biomedical Informatics Research Network: A national initiative to advance biomedical research through data sharing and online collaboration. .. focuses directly on the biomedical research community's unique, data-intensive sharing and analysis needs, which are particularly evident in fields such as biomedical imaging and genetics. a user-driven, software-based framework for research teams to share significant quantities of data – rapidly, securely and privately – across geographic distance and/or incompatible computing systems. ... We also offer data-sharing software tools specific to biomedical research, best practices references, expert advice and other resources. http://www.nbirn.net/
case definition : Optimal case definition is important in epidemiological research, but can be problematic when no satisfactory gold standard is available. In particular, difficulties arise where the pathology underlying a disorder is unknown or cannot be reliably diagnosed. This problem can be overcome if diagnoses are viewed not necessarily as labels for disease processes, but more generally as a useful method for classifying people for the purpose of preventing or managing illness. With this perspective, the value of a case definition lies in its practical utility in distinguishing groups of people whose illnesses share the same causes or determinants of outcome (including response to treatment). A corollary is that the best-case definition for a disorder may vary according to the purpose for which it is being applied. Assessing case definitions in the absence of a diagnostic gold standard, D Coggon, C Martyn, KT Palmer, B Evanoff, Intl J Epidemiol 34 (4): 949-952
Clinical Data Interchange Standards Consortium:
open, multidisciplinary, non- profit organization committed to the development
of industry standards to support the electronic acquisition, exchange,
submission and archiving of clinical trials data and metadata for medical and
biopharmaceutical product development. http://www.cdisc.org/
& translational informatics:
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concept of clinical bioinformatics was recently defined in the Open Editorial of
Journal of Clinical Bioinformatics (JCBi) by Drs Wang and Liotta. Concept of
clinical bioinformatics was proposed to be "a new emerging science combining
clinical informatics, bioinformatics, medical informatics, information
technology, mathematics, and omics science together". In order to emphasize
their understanding, they further defined the term "Clinical
bioinformatics" as "clinical application of bioinformatics-associated
sciences and technologies to understand molecular mechanisms and potential
therapies for human diseases", a new and important concept for the
development of disease-specific biomarkers, mechanism-oriented understanding and
individualized medicine. About
the Journal of Clinical Bioinformatics http://www.jclinbioinformatics.com/about
clinical data repositories, shared: Agency for Healthcare Research & Quality http://healthit.ahrq.gov/portal/server.pt?open=514&objID=5554&mode=2&holderDisplayURL=http://prodportallb.ahrq.gov:7087/publis
forecasting: It is clear that late-stage clinical failures
account for a large proportion of the expenses. This can be as a result of both
the large out-of-pocket investments in Phase III clinical trials and because
unsuccessful trials tie up capital resources during their conduct, and
potentially also for the time spent during any attempted recovery following
regulatory rejection. So, there is an interest in strategies that could halt, as
early as possible, the development of drugs that eventually fail. Clinical
forecasting in drug development, Asher D. Schachter and Marco F. Ramoni,
Nature Reviews Drug Discovery 6, 107-108 (February 2007) |
doi:10.1038/nrd2246 http://www.nature.com/nrd/journal/v6/n2/full/nrd2246.html
clinical informatics:
Clinical Research Informatics World May
6-7, 2015 • Boston, MA Program | Register | Download
is the application of informatics and information technology to
deliver healthcare services. It is also referred to as applied clinical
informatics and operational informatics. AMIA considers informatics when used
for healthcare delivery to be essentially the same regardless of the health
professional group involved (whether dentist, pharmacist, physician, nurse, or
other health professional). Clinical Informatics is concerned with information
use in health care by clinicians. Clinical informatics includes a wide range of
topics ranging from clinical decision support to visual images (e.g.
radiological, pathological, dermatological, ophthalmological, etc); from
clinical documentation to provider order entry systems; and from system design
to system implementation and adoption issues. AMIA Clinical informatics http://www.amia.org/applications-informatics/clinical-informatics
The application of informatics
approaches to the clinical- evaluation phase of drug development. These
approaches can include clinical- trial simulations to improve trial design and
patient selection, as well as electronic capturing and storing of clinical data
and protocols. The goal is to reduce expenses and time to market
clinical ontologies: Open Clinical Ontologies http://www.openclinical.org/ontologies.html support from Cancer Research UK
clinical trial data model:
Phase Forward Submits XML-based Clinical Trial Data
Model to Worldwide Standards Organizations, 1999 http://www.oasis-open.org/cover/phaseCDISC19990621.html
clinomics: The application of oncogenomic research. Daniel von Hoff, Univ. of Arizona "All hands on deck at dawn" Nature Genetics 27 (4): 347-349, April 2001
cluster analysis: The clustering, or grouping, of large data sets (e.g., chemical and/ or pharmacological data sets) on the basis of similarity criteria for appropriately scaled variables that represent the data of interest. Similarity criteria (distance based, associative, correlative, probabilistic) among the several clusters facilitate the recognition of patterns and reveal otherwise hidden structures (Rouvray, 1990; Willett, 1987, 1991). IUPAC Computational
A set of statistical methods used to group variables or observations into strongly inter- related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health- related phenomenon with well- defined distribution patterns in relation to time or place or both. MeSH, 1990
Has been used in medicine to create taxonomies of diseases and diagnosis and in archaeology to establish taxonomies of stone tools and funereal objects. Cluster analysis can be supervised, unsupervised or partially supervised Related terms: clustering analysis, dendogram, heat map, pattern recognition, profile chart. Narrower terms: hierarchical clustering, k-means clustering, self- organizing maps
clustering analysis: This is a general type of analysis that involves grouping gene or array expression profiles based on similarity. Clustering is a major subfield within the broad world of numerical analysis, and many specific clustering methods are known.
cohort studies large
scale: In
the past 20 years, birth cohort studies to assess the risks to developing
children from harmful chemicals in air, water and food have been undertaken in
many countries. These birth cohort studies usually started during pregnancy and
followed children through adolescence or beyond. Even the largest of these birth
cohort studies, however, were not big enough to study rare outcomes such as
childhood cancer or sudden infant death syndrome. To increase the sample size,
investigators working with these older cohort studies are now making an effort
to pool their data. Their efforts are hampered by the fact that the older
studies did not usually agree upon disease outcome definitions, time periods of
measurement, or methods for measuring biomarkers and chemical contaminants in
air, water and food. This makes pooling data extremely difficult.
communications standards: It is clear that shared understanding of the basic data elements within pharmacogenomics is a critical building block upon which to build an information infrastructure. Methods for communicating these data are therefore equally as important. The two main areas that require progress are the definition of shared syntax (how information is structured in a data file) and semantics (how the information should be interpreted by others). Russ Altman "Challenges for Biomedical Informatics and Pharmacogenomics, Stanford Medical Informatics, 2002 http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.42.082401.140850 Related terms: Information management & interpretation controlled vocabularies, syntax, semantics
comparative data mining:
Algorithms &
data management
Useful for clinical trial meta-analyses
effectiveness research CER:
the conduct and synthesis of systematic research comparing different
interventions and strategies to prevent, diagnose, treat and monitor health
conditions. The purpose of this research is to inform patients, providers, and
decision-makers, responding to their expressed needs, about which interventions
are most effective for which patients under specific circumstances. To provide
this information, comparative effectiveness research must assess a comprehensive
array of health-related outcomes for diverse patient populations… [Internet.] Federal Coordinating Council for Comparative
Effectiveness Research [cited 28 July 2010].
Comparative Effectiveness Research, Health Services Research Information
Central, National Library of Medicine, NIH http://www.nlm.nih.gov/hsrinfo/cer.html
complex: It has become common to use complicated and complex interchangeably … The essence of 'complicated' is hard to figure out. ..Complex, on the other hand is a term reserved for systems that display properties that are not predictable from a complete description of their components, and that are generally considered to be qualitatively different from the sum of their parts. [Editorial, "Complicated is not complex" Nature Biotechnology 17: 511 June 1999] Would it be fair to say that Mendelian genetics is linear, while genomics and polygenic diseases/traits are nonlinear?
According to the Oxford English Dictionary one of the meanings of complicated is complex, though it also means not easy to unravel or separate. Both complex and complicated are contrasted with simple. Whatever the original senses of these two words, the above distinction seems a useful one now. Related term: complexity; Narrower terms: biocomplexity, complex diseases, complex genomes; complex phenotypes, complex traits
complex diseases: Diseases characterized by risk to relatives of an affected individual which is greater than the incidence of the disorder in the population. [NHLBI]
The research activities in the Department of Genetics and Complex Diseases and its pre and postdoctoral training programs concentrate on the molecular, cellular, and organismic adaptations and responses to nutrients, toxins, and radiation stress and explore the genetic basis controlling the heterogeneity of these interactions in experimental systems. The integrated interdisciplinary opportunities also aim to apply this knowledge to human populations to understand, prevent, and treat complex human diseases. Dept of Genetics and Complex Diseases, Harvard School of Public Health 2011 http://www.hsph.harvard.edu/departments/genetics-and-complex-diseases/
How are complex diseases related to polygenic diseases? Related terms: SNPs & genetic variations; Omes & omics phenome, phenomics
computational pharmacology: Pharmacogenomics
computational physiology: The International Union of Physiological Sciences (IUPS) Physiome Project is an internationally collaborative open- source project to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales [1,2,3]. It aims to develop an infrastructure for linking models of biological structure and function across multiple levels of spatial organization and multiple time scales. The levels of biological organisation, from genes to the whole organism, includes gene regulatory networks, protein- protein and protein- ligand interactions, protein pathways, integrative cell function, tissue and whole heart structure- function relations. The whole heart models include the spatial distribution of protein expression. Keynote: Peter J. Hunter, Univ of Auckland, International Society of Computational Biology, Detroit, MI, 2005 http://www.iscb.org/ismb2005/keynotes.html
computational therapeutics: An emerging biomedical field. It is concerned with the development of techniques for using software to collect, manipulate and link biological and medical data from diverse sources. It is also concerned with the use of such information in simulation models to make predictions or therapeutically relevant discoveries or advances. (Referred to by some as in silico pharmacology) C. Anthony Hunt Lab, Biosystems at Univ. of California, San Francisco, http://biosystems.ucsf.edu/
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digital health: Digital health is not a new concept. Seth Frank, writing 13 years ago, penned "Digital Health Care—The convergence of health care and the Internet" in The Journal of Ambulatory Care Management. Today, technology is rapidly transforming healthcare. Eric Topol's The Creative Destruction of Medicine enumerates how these digital technologies, social networking, mobile connectivity and bandwidth, increasing computing power and the data universe will converge with wireless sensors, genomics, imaging, and health information systems to creatively destroy medicine as we know it. He refers to this as digital medicine, or the digitization of human beings. At Rock Health, we support entrepreneurs working in the space Topol describes—at the intersection of healthcare and technology; and not solely in medicine, but across healthcare, including wellness and administration. As part of our research, we track companies and catalog venture funding in the digital health space. Defining digital health and choosing which companies to include is complex, so here is some transparency as to how we catalog deals: What Digital Health is [and Isn't) Rock Health http://rockhealth.com/2013/04/what-digital-health-is-and-isnt/
health is the convergence of the digital and genetics revolutions with
health and healthcare. As we are seeing and experiencing, digital health
is empowering us to better track, manage, and improve our own and our
family's health. It's also helping to reduce inefficiencies in
healthcare delivery, improve access, reduce costs, increase quality, and
make medicine more personalized and precise. … The
essential elements of the digital health revolution include wireless
devices, hardware sensors and software sensing technologies,
microprocessors and integrated circuits, the Internet, social networking,
mobile and body area networks, health information technology, genomics,
and personal genetic information. The lexicon of Digital Health is
extensive and includes all or elements of mHealth (aka Mobile Health),
Wireless Health, Health 2.0, eHealth, Health IT, Big Data, Health Data,
Cloud Computing, e-Patients, Quantified Self and Self-tracking, Wearable
Computing, Gamification, Telehealth & Telemedicine, Precision and
Personalized Medicine, plus Connected Health. Story of Digital Health,
Paul Sonnier, 2014 http://storyofdigitalhealth.com/definition/
drug utilization:
utilization of drugs as reported in individual hospital studies, FDA studies,
marketing, or consumption, etc. This includes drug stockpiling, and patient drug
profiles. MeSH, 1973
drug utilization review: Formal programs for assessing drug prescription against some standard. Drug
utilization review may consider clinical appropriateness, cost effectiveness,
and, in some cases, outcomes. Review is usually retrospective, but some analysis
may be done before drugs are dispensed (as in computer systems which advise
physicians when prescriptions are entered). Drug utilization review is mandated
for Medicaid programs beginning in 1993. MeSH, 1994 Related terms: ATC/DDD, EPhMRA,
Technical Document: The Electronic
Common Technical Document (eCTD) is CDER/CBER's standard format for electronic
regulatory submissions. The FDA would like to work closely with people who
plan to provide a submission using the eCTD specifications FDA, Common Technical
Document http://www.fda.gov/Drugs/DevelopmentApprovalProcess/FormsSubmissionRequirements/ElectronicSubmissions/ucm153574.htm
Electronic Common Technical Document,
Wikipedia http://en.wikipedia.org/wiki/Electronic_Common_Technical_Document
drug utilization: The utilization of drugs as reported in individual hospital studies, FDA studies, marketing, or consumption, etc. This includes drug stockpiling, and patient drug profiles. MeSH, 1973
drug utilization review: Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993. MeSH, 1994 Related terms: ATC/DDD, EPhMRA, PBIRG
eCommon Technical Document: The Electronic Common Technical Document (eCTD) is CDER/CBER's standard format for electronic regulatory submissions. The FDA would like to work closely with people who plan to provide a submission using the eCTD specifications FDA, Common Technical Document http://www.fda.gov/Drugs/DevelopmentApprovalProcess/FormsSubmissionRequirements/ElectronicSubmissions/ucm153574.htm
Electronic Common Technical Document, Wikipedia http://en.wikipedia.org/wiki/Electronic_Common_Technical_Document
EDC electronic data capture: Wikipedia http://en.wikipedia.org/wiki/Electronic_Data_Capture
effectiveness research: See comparative effectiveness research, see also under outcomes research
e-health: http://en.wikipedia.org/wiki/EHealth
Health Records EHRs: Electronic
Health Records (EHRs) are safe and confidential records that your doctor, other
health care provider, medical office staff, or a hospital keeps on a computer
about your health care or treatments. If your providers use electronic health
records, they can join a network to securely share your records with each other.
EHRs can help lower the chances of medical errors, eliminate duplicate tests,
and may improve your overall quality of care.
EHRs can help your providers have the same up-to-date information about
your conditions, treatments, tests, and prescriptions. Electronic Health
Records, Medicare.gov http://www.medicare.gov/manage-your-health/electronic-health-records/electronic-health-records.html
healthcare environment will be profoundly changed by the convergence of
technology, and ready access to updated patient information. The program will
cover the use of combinatorial device technology to integrate healthcare
systems, and the novel connectivity of global electronic medical record efforts.
Clinical management of disease will be addressed through the use of handheld and
point-of-care devices. The value of real time patient information to the
clinical management team and the pharmaceutical researcher will be leveraged
while addressing the ethical and legal implications.
Agency for Healthcare
Research & Quality,
electronic records -- FDA:
Electronic standards for
the transfer of regulatory information,
Glossary of Abbreviations and Terms ICH m2 2005 http://estri.org/recommendations/Glossary.pdf
evidence based medicine: Evidence-based medicine is defined in the Roundtable's charter to mean that: to the greatest extent possible, the decisions that shape the health and health care of Americans– by patients, providers, payers and policymakers alike—will be grounded on a reliable evidence base, will account appropriately for individual variation in patient needs, and will support the generation of new insights on clinical effectiveness. Institute of Medicine, Round Table on Evidence Based Medicine http://www.iom.edu/CMS/AboutIOM/28189.aspx
genomic epidemiology: An emerging discipline involving population studies and microarray/ expression studies. Related terms: environmental factors, public health; molecular epidemiology, human genome epidemiology, phenotypic prevention
GIS Geographic Information Systems and: GIS link data and geography digitally for the purpose of making maps. This technology often provides a useful way to reveal spatial and temporal relationships among data. Researchers, public health professionals, policy makers, and others use GIS to better understand geographic relationships that affect health outcomes, public health risks, disease transmission, access to health care, and other public health concerns. GIS and Public Health, National Center for Health Statistics, 2007 http://www.cdc.gov/nchs/gis.htm
health informatics: "the interdisciplinary study of the design, development, adoption and application of IT-based innovations in healthcare services delivery, management and planning." Procter, R. Dr. (Editor, Health Informatics Journal, Edinburgh, United Kingdom). Definition of health informatics [Internet]. Message to: Virginia Van Horne (Content Manager, HSR Information Central, Bethesda, MD). 2009 Aug 16 [cited 2009 Sept 21]. National Library of Medicine http://www.nlm.nih.gov/hsrinfo/informatics.html Related terms: biomedical informatics, healthcare informatics, medical informatics Wikipedia http://en.wikipedia.org/wiki/Health_informatics
health IT tools: Agency for Healthcare Research & Quality, http://healthit.ahrq.gov/portal/server.pt?open=512&objID=919&parentname=CommunityPage&parentid=9&mode=2&in_h
health record: Historically, the definition of a legal medical or health record seemed straightforward. The contents of the paper chart formed the provider of care's legal business record. Patients had limited interest in or access to the information contained in their record. With the advent of various electronic media, the Internet, and the consumer's enhanced role in compiling health records, the definition of the legal health record became more complex. The need remains to ensure information is accessible for its ultimate purposes regardless of the technologies employed or users involved. The definition of the legal health record (LHR) must therefore be reassessed in light of such new technologies, users, and uses. Amatayakul, Margret et al. "Definition of the Health Record for Legal Purposes (AHIMA Practice Brief)." Journal of AHIMA 72, no.9 (2001): 88A-H. http://library.ahima.org/xpedio/groups/public/documents/ahima/bok1_009223.hcsp?dDocName=bok1_009223
Healthcare Informatics: For years, the [IBM] Almaden Research Center has been at the vanguard of research into healthcare informatics. Our contributions to the Nationwide Health Information Network (NHIN), developed under contract to the U.S. Department of Health and Human Services, have paved the way for many other health IT research advances. The NHIN prototype pioneered new standards-based technology for secure access and real time sharing and exchanging of health care data among all concerned parties—patients, physicians, hospitals, laboratories, and pharmacies. Other groundbreaking work in fields as diverse as privacy protection and interoperability has cemented IBM's status as a forerunner in the field. Today, we continue to push forward in a number of new areas, including Information Integration, Multimodal Analytics, Healthcare Standards, and Public Health. http://www.almaden.ibm.com/cs/disciplines/hc/
Wikipedia http://en.wikipedia.org/wiki/Healthcare_informatics
Health Level Seven is one of several American
National Standards Institute (ANSI) -accredited Standards Developing
Organizations (SDOs) operating in the healthcare arena. … Health Level
Seven's domain is clinical and administrative data. "Level
Seven" refers to the highest level of the International Organization
for Standardization (ISO) communications model for Open Systems
Interconnection (OSI) - the application level. http://www.hl7.org/
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human factors: Human factors/usability engineering focuses on the interactions between people and devices. The critical element in these interactions is the device user interface ... Human factors/usability engineering is used to design the machine-human (device-user) interface. The user interface includes all components with which users interact while preparing the device for use (e.g., unpacking, set up, calibration), using the device, or performing maintenance (e.g., cleaning, replacing a battery, making repairs). FDA, CDHR Medical Devices General Human Factors Information and Resources http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/HumanFactors/ucm124829.htm
computational immunology, is an emerging area that provides fundamental
methodologies in the study of immunomics, that is, immune-related genomics and
proteomics. The integration of immunoinformatics with systems biology approaches
may lead to a better understanding of immune-related diseases at various systems
levels. Such methods can contribute to translational studies that bring
scientific discoveries of the immune system into better clinical practice. One
of the most intensely studied areas of the immune system is immune epitopes.
Epitopes are important for disease understanding, host-pathogen interaction
analyses, antimicrobial target discovery, and vaccine design. The information
about genetic diversity of the immune system may help define patient subgroups
for individualized vaccine or drug development. Cellular pathways and host
immune-pathogen interactions have a crucial impact on disease pathogenesis and
immunogen design. Epigenetic studies may help understand how environmental
changes influence complex immune diseases such as allergy. High-throughput
technologies enable the measurements and catalogs of genes, proteins,
interactions, and behavior. Such perception may contribute to the understanding
of the interaction network among humans, vaccines, and drugs, to enable new
insights of diseases and therapeutic responses. The integration of immunomics
information may ultimately lead to the development of optimized vaccines and
drugs tailored to personalized prevention and treatment. Methods
Mol Biol. 2010;662:203-20.
doi: 10.1007/978-1-60761-800-3_10. Immunoinformatics
and systems biology methods for personalized medicine. Yan
clinical trials: See computer trials simulations
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laboratory informatics: the specialized application of information technology aimed at optimizing laboratory operations. It is a collection of informatics tools utilized within laboratory environments to collect, store, process, analyze, report, and archive data and information from the laboratory and supporting processes. Laboratory informatics includes the integration of systems, the electronic delivery of results to customers, and the supporting systems including training and policies. Examples of laboratory informatics include: Laboratory Information Management Systems (LIMS), Electronic Laboratory Notebooks (ELNs), Chromatography Data Systems (CDS), and Scientific Data Management Systems (SDMS). ASTM E1578 Standard Guide for Laboratory Informatics 2013 http://www.astm.org/Standards/E1578.htm Wikipedia http://en.wikipedia.org/wiki/Laboratory_informatics Related term?: Drug discovery & development LIMS
LOINC Logical Observation
Identifiers Names and Codes:
The purpose of the LOINC database is to facilitate the exchange and
pooling of results, such as blood hemoglobin, serum potassium, or vital
signs, for clinical care, outcomes management, and research. Regenstrief
Institute Inc. Germany http://www.loinc.org/
is using certified electronic health record (EHR) technology to: Improve
quality, safety, efficiency, and reduce health disparities, Engage patients and
family, Improve care coordination, and population and public health, Maintain
privacy and security of patient health information, Ultimately, it is hoped that
the meaningful use compliance will result in: Better clinical outcomes, Improved
population health outcomes, Increased transparency and efficiency, Empowered
individuals, More robust research data on health systems HealthIT.gov HER
Incentives and Certification http://www.healthit.gov/providers-professionals/meaningful-use-definition-objectives
medical bioinformatics: Linking clinical data to patient gene profiling. Covers haplotyping, genotyping, population genomics, gene expression profiling, particularly for use in diagnosis, prognosis and therapeutic stratification of patients. Related terms: Biomarkers, Expression, Microarrays and protein chips
medical informatics: The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine. MeSH, 1987
An emerging discipline that has been defined as the study, invention, and implementation of structures and algorithms to improve communication, understanding and management of medical information. The end objective of biomedical informatics is the coalescing of data, knowledge, and the tools necessary to apply that data and knowledge in the decision- making process, at the time and place that a decision needs to be made. The focus on the structures and algorithms necessary to manipulate the information separates Biomedical Informatics from other medical disciplines where information content is the focus. Medical Informatics FAQ, 1999 http://www.faqs.org/faqs/medical-informatics-faq/
MedDRA Medical Dictionary
for Regulatory Activities:
by the International Conference on Harmonisation (ICH) and is owned by the
International Federation of Pharmaceutical Manufacturers and Associations
(IFPMA) acting as trustee for the ICH steering committee. http://www.meddramsso.com/
meta-analysis: The use of statistical techniques in a systematic review to integrate the results of included studies. Sometimes misused as a synonym for systematic reviews, where the review includes a meta- analysis. Cochrane Collaboration "Glossary of terms in the Cochrane Collaboration, 2014 http://www.cochrane.org/glossary/5
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine. MeSH, 1989
Meta-regression is an extension to subgroup analyses
that allows the effect of continuous, as well as categorical, characteristics
to be investigated, and in principle allows the effects of multiple factors to
be investigated simultaneously (although this is rarely possible due to
inadequate numbers of studies) (Thompson 2002). Meta-regression should
generally not be considered when there are fewer than ten studies in a
meta-analysis. General Methods for Cochran Reviews, Cochran
Collaborative http://handbook.cochrane.org/chapter_9/9_6_4_meta_regression.htm
mHealth mobile
health: With
the emergence of new technologies such as mobile devices and wearables, the
pharma and biotech industry are poised to capitalize on these advancements to
innovate existing clinical trial processes and systems. Advancing technological
innovation in clinical trials coincides with the move toward greater
cross-industry clinical trial data sharing and clinical data transparency.
Coupled together new technological advances and increased clinical trial data
sharing leads to more efficient clinical trials.
National Center for
Integrative Biomedical Informatics: http://portal.ncibi.org/gateway/
of seven National Centers
for Biomedical Computing (NCBC)
within the NIH Roadmap. The NCBC program is focused on building a universal
computing infrastructure designed to speed progress in biomedical research.
National Electronics Clinical Trials and Research
An enriched pipeline of biomedical discoveries, an infrastructure to facilitate
the translation of these discoveries from the laboratory to the clinic, and a
robust force of clinical investigators will make it possible to test new
therapeutic and preventive strategies in larger numbers of patients far sooner
than currently possible. These large studies are often best conducted through
networks of investigators who are equipped with tools to facilitate
collaboration and information sharing. Because of the vast number of therapies,
diagnostics, and treatments that must be evaluated through clinical trials, many
clinical research networks operate simultaneously, but independently, of each
other. As a result, researchers must sometimes duplicate data that already
exists because they are unaware of the data or do not have access to the data.
Standardizing data reporting would enable seamless data- and sample-sharing
across studies. By enhancing the efficiency of clinical research networks
through informatics and other technologies, researchers will be better able to
broaden the scope of their research. Reduced duplication of studies will leave
more time and funds to address additional research questions.
NECTAR, NIH Common Fund http://commonfund.nih.gov/clinicalresearch/overview-networks.aspx
neuroimaging: Neuroimaging informatics tools and resources http://www.nitrc.org/
neuroinformatics: Neuroinformatics publishes original articles and reviews in the new field of neuroinformatics. The emphasis is on data structure and software tools related to analysis, modeling, integration, and sharing, in all areas of neuroscience research. In particular, we invite contributions on: (1) Theory and methodology, including discussions on ontologies, modeling approaches, database design and meta-analyses; (2) Descriptions of developed databases and software tools, and of the methods for their distribution; (3) Relevant experimental results, such as reports accompanied by the release of massive data sets; (4) Computational simulations of models integrating and organizing complex data; and (5) Neuroengineering approaches, including hardware, robotics, and information theory studies. The journal also publishes independent "tests and evaluations" of available neuroscience databases and software tools and fosters a commitment to the principles of tool and data sharing. Aims and Scope, Neuroinformatics, Humana Press
Neuroinformatics: The Human Brain Project, National Institute of
Mental Health, NIH, US, 2008 http://wwwapps.nimh.nih.gov/research-funding/scientific-meetings/recurring-meetings/human-brain-project/index.shtml
Nuclear Morphometric Descriptors NMD: Today's imaging technology uses sophisticated hardware platforms coupled with powerful and user-friendly software packages that are commercially available as complete image analysis systems. There are many different mathematically derived nuclear morphometric descriptors (NMD's) (i.e. texture features) that can be calculated by these image analysis systems, but for the most part, these NMD's quantify nuclear size, shape, DNA content (ploidy), and chromatin organization (i.e. texture, both Markovian and non-Markovian) parameters. We have utilized commercially available image analysis systems and the NMD's calculated by these systems to create a mathematical solution, termed quantitative nuclear grade (QNG), for making clinical, diagnostic, and prognostic outcome predictions in both prostate and bladder cancer. "Quantitative nuclear grade (QNG): a new image analysis- based biomarker of clinically relevant nuclear structure alterations" Veltri RW, Partin AW, Miller MC, Journal of Cell Biochemistry Suppl 35: 151-157, 2000
Office of the National Coordinator for Health Information Technology (ONC): is at the forefront of the administration's health IT efforts and is a resource to the entire health system to support the adoption of health information technology and the promotion of nationwide health information exchange to improve health care. . http://www.aids.gov/federal-resources/federal-agencies/hhs/office-of-the-national-coordinator-for-health-information-technology/
outcomes research: The terms "outcomes research" and "effectiveness research" have been used to refer to a wide range of studies, and there is no single definition for either that has gained widespread acceptance. As these fields evolved, it appears that "outcomes research" emerged from a new emphasis on measuring a greater variety of impacts on patients and patient care (function, quality of life, satisfaction, readmissions, costs, etc). The term "effectiveness research" was used to emphasize the contrast with efficacy studies, and highlighted the goal of learning how medical interventions affected real patients in "typical" practice settings (OTA, 1994). Effectiveness studies sought to understand the impact of health care on patients with diverse characteristics, rather than highly homogeneous study populations. While the terms may have different initial roots, there does not appear to be much value in distinguishing these activities, and the field is generally referred to as OER. .. OER evaluates the impact of health care (including discrete interventions such as particular drugs, medical devices, and procedures as well as broader programmatic or system interventions) on the health outcomes of patients and populations. OER may include evaluation of economic impacts linked to health outcomes, such as cost- effectiveness and cost utility. OER emphasizes health problem- (or disease-) oriented evaluations of care delivered in general, real- world settings; multidisciplinary teams; and a wide range of outcomes, including mortality, morbidity, functional status, mental well- being, and other aspects of health-related quality of life. Outcome of Outcomes Research at AHCPR: Final Report, Agency for Health Care Policy and Research, AHCPR Publication No. 99-R044 http://www.ahrq.gov/clinic/out2res/outcom1.htm Related term: comparative effectiveness research
patient engagement: Surgeon General C Everett Koop once said "Drugs don't work in patients who don't take them." I'll offer a corollary of my own: Patients who aren't engaged don't comply with therapies or report complications. Enabling Patient Engagement and Healthcare Innovation, FDA Testimony Healthcare Innovation DDMAC Public Hearings on Internet & Social Media #FDASM Zen Chu, 2009 http://www.slideshare.net/MedicalVentures/zen-chu-healthcare-innovation-fda-testimony-ddmac-public-hearings-on-internet-social-media
Patient Care, Engagement and Empowerment
May 4-5, 2015 • Boston, MA Program | Register | Download
patient reported outcomes: the PROMIS (Patient-Reported Outcomes Measurement Information System) initiative is developing new ways to measure patient-reported outcomes (PROs), such as pain, fatigue, physical functioning, emotional distress, and social role participation that have a major impact on quality-of-life across a variety of chronic diseases. Clinical measures of health outcomes, such as x-rays and lab tests, may have minimal relevance to the day-to-day functioning of patients with chronic diseases. Often, the best way patients can judge the effectiveness of treatments is by changes in symptoms. The goal of PROMIS is to improve the reporting and quantification of changes in PROs. PROMIS Patient Reported Outcomes, NIH Common Fund http://commonfund.nih.gov/promis/overview.aspx
Health Record PHR: The PHR is a tool that you can use to collect,
track and share past and current information about your health or the health of
someone in your care. Sometimes this information can save you the money and
inconvenience of repeating routine medical tests. Even when routine procedures
do need to be repeated, your PHR can give medical care providers more insight
into your personal health story. AHIMA, MyPHR - http://www.myphr.com/startaphr/what_is_a_phr.aspx#sthash.gyUVxDmV.dpuf
Pharmacoepidemiology focuses heavily on questions of pharmacodynamics, concentrating on clinical patient outcomes and on therapeutics (i.e., appropriate use of drugs), and to a lesser extent on pharmacokinetics. Penn Medicine University of Pennsylvania http://www.cceb.upenn.edu/research/pharmaco.php
II clinical trials design:
optimal design of phase II studies continues to be the subject of vigorous
debate, especially studies of newer molecularly targeted agents. The
observations that many new therapeutics "fail" in definitive phase III
studies, coupled with the numbers of new agents to be tested as well as the
increasing costs and complexity of clinical trials, further emphasize the
critical importance of robust and efficient phase II design.
Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus
Recommendations from the Clinica l Trial Design Task Force of the National
Cancer Institute Investigational Drug Steering Committee. Seymour L, et.
Cancer Res. 2010 Mar 9. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/20215557
clinical trials:
intermediate-sized clinical trials supported through this RFA are a
pivotal decision point in the NCI chemoprevention drug development
program. The consensus view of a Working Group from the NCI and the FDA
acknowledges that "the interim analysis of a validated surrogate
endpoint of cancer incidence may facilitate the timely and
cost-effective marketing of efficacious drugs (Kelloff et al., Cancer
Epidemiol. Biomark. Prev. 4: 1-10, 1995)." Thus, the efficacy and
safety data from these studies potentially supports FDA marketing
approval (NDA applications) for chemoprevention indications, and
certainly facilitates decisions regarding the most appropriate
recommendations for subsequent large, community-based efficacy studies.
Pivotal clinical trials for chemoprevention clinical development
National Cancer Institute, NIH RFA: CA-98-001 1997 http://grants.nih.gov/grants/guide/rfa-files/rfa-ca-98-001.html
Health Management and Quality Improvement May
4-5, 2015 • Boston, MA Program | Register | Download
predictive biomedicine: Predictive Biomedicine (PB) will cover the development and use of informatics and computational tools to manage, present, and interpret experimental data as well as those used in modeling and bio-simulation. Companies and thought-leaders; products and technologies; relevant research programs and their results will be covered. From data management challenges to systems biology initiatives, PB will report on industry's efforts to reduce dependence on trial and error and adopt more data-driven predictive methods to drive drug discovery and development and even health care delivery. John Russell, editor Predictive Biomedicine eNewsletter, Sept 2008 http://www.bio-itworld.com/issues/2008/sept/russell-transcript-predictive-biomedicine.html?terms=GNS%3A+Building+a+SNPs-to-Outcomes+Engine
predictive genomics: Wayne D. Hall1,+, Katherine I. Morley1,2 and Jayne C. Lucke1, The prediction of disease risk in genomic medicine: Scientific prospects and implications for public policy and ethics EMBO reports vol. 5 | Suppl 1 | pp S22-S26 | 2004 DOI: 10.1038/sj.embor.7400224 See also Pharmacogenomics predictive pharmacogenomics
prognosis: The probable outcome or course of a disease; the chance of recovery. [ORD]
Not a major emphasis in clinical medicine today. Nicholas Christakis' Death Foretold is an eloquent book about the delicate balance between medical reality and optimism, and how seldom this is discussed in either classrooms or hospital rooms today.
public health informatics: The systematic application of information and computer sciences to public health practice, research, and learning. It is the discipline that integrates public health with information technology. The development of this field and dissemination of informatics knowledge and expertise to public health professionals is the key to unlocking the potential of information systems to improve the health of the nation. www.nlm.nih.gov/pubs/cbm/phi2001.html MeSH 2003
the application of informatics in areas of public health, including
surveillance, prevention, preparedness, and health promotion. Public health
informatics and the related population informatics, work on information and
technology issues from the perspective of groups of individuals. Public health
is extremely broad and can even touch on the environment, work and living places
and more. Generally, AMIA focuses on those aspects of public health that enable
the development and use of interoperable information systems for public health
functions such as biosurveillance, outbreak management, electronic laboratory
reporting and prevention.
AMIA Public Health Informatics http://www.amia.org/applications-informatics/public-health-informatics
real world data: Data collected in real-world health environments (as opposed to controlled clinical trials) provides valuable insights into the usage and comparative effectiveness of various treatments. Real-world data can include: De-identified health data collected as a by-product of patient care Collection and analysis of observational data Electronic medical record (EMR) system data used for cohort discovery Condition-specific data marts based on de-identified inpatient data. Cerner, Real world data http://www.cerner.com/solutions/Research/Real-World_Data/
security healthcare data: Security and Access of Healthcare Data May 4-5, 2014 • Boston, MA Program | Register | Download Brochure
Systematized Nomenclature of Medicine:
Terminology and
implementation support products and services. College of American
Pathologists http://www.snomed.org/
medicine: http://en.wikipedia.org/wiki/Systems_medicine
telehealth: Leveraging mHealth, Telehealth and the Cloud May 4-5, 2015 • Boston, MA Program | Register | Download Brochure
Agency for healthcare research & quality http://healthit.ahrq.gov/portal/server.pt?open=514&objID=5554&mode=2&holderDisplayURL=http://prodportall
telemedicine: http://en.wikipedia.org/wiki/Telemedicine
the development of storage, analytic, and interpretive methods to optimize the
transformation of increasingly voluminous biomedical data, and genomic data,
into proactive, predictive, preventive, and participatory health. Translational
bioinformatics includes research on the development of novel techniques for the
integration of biological and clinical data and the evolution of clinical
informatics methodology to encompass biological observations. The end product of
translational bioinformatics is newly found knowledge from these integrative
efforts that can be disseminated to a variety of stakeholders, including
biomedical scientists, clinicians, and patients. AMIA Translational
bioinformatics http://www.amia.org/applications-informatics/translational-bioinformatics
PLOS Computational Biology Translational Bioinformatics http://www.ploscollections.org/article/browseIssue.action?issue=info:doi/10.1371/issue.pcol.v03.i11
UMLS Unified Medical Language System In 1986, the National Library of Medicine (NLM), began a long term research and development project to build a Unified Medical Language System ® (UMLS ® ). The purpose of the UMLS is to aid the development of systems that help health professionals and researchers retrieve and integrate electronic biomedical information from a variety of sources and to make it easy for users to link disparate information systems, including computer- based patient records, bibliographic databases, factual databases, and expert systems. The UMLS project develops "Knowledge Sources" that can be used by a wide variety of applications programs to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. UMLS FactSheet, National Library of Medicine, NIH, US http://www.nlm.nih.gov/pubs/factsheets/umls.html
uncertainty factor: Mathematical adjustments for reasons of safety when knowledge is incomplete. For example, factors used in the calculation of doses that are not harmful (adverse) to people. These factors are applied to the lowest-observed-adverse-effect-level (LOAEL) or the no-observed-adverse-effect-level (NOAEL) to derive a minimal risk level (MRL). Uncertainty factors are used to account for variations in people's sensitivity, for differences between animals and humans, and for differences between a LOAEL and a NOAEL. Scientists use uncertainty factors when they have some, but not all, the information from animal or human studies to decide whether an exposure will cause harm to people [also sometimes called a safety factor]. ATSDR Glossary, Agency for Toxic Substances & Disease Registry, http://www.atsdr.cdc.gov/glossary.html 2009
virtual cancer patient: Cancer
women's health - statistical modeling: Gender differences in prevalence, risk and course of a variety of health outcomes depend upon a complex interplay of factors, including biological, social and psychological factors. The multivariate nature of our research hypotheses poses significant problems for the design and interpretation of studies in women's health. The statistical modeling core is committed to the application and development of multivariate techniques that are vital to the testing of these hypotheses. Women's Health Research at Yale, Statistical Modeling, http://info.med.yale.edu/womenshealth//research/statistic.html
Insight Pharma Reports Informatics series http://www.insightpharmareports.com/Reports/All.aspx?s=NFO
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text:
Fireworks will light the sky tonight as Discover! '99 signals the official end of summer at the Don Harrington Discovery Center.
The daylong celebration will include entertainment, food and special events capped by a Amarillo Symphony concert sparked with fireworks.
"The entire Panhandle is invited to join us as we say goodbye to summer," said Patty Duke, development director of the center.
Discover! '99 will open to the public at 10 a.m. with Top of Texas Kite Club demonstrations and the opening of the Discovery Center's normal programming, including the summer exhibit "Captain Abdul's Pirate School."
Concession stands and the expanded children's area will open at 1 p.m. Concession stands will offer food and drinks including turkey legs, ice cream, corn-on-the-cob, snow cones, curly fries, funnel cakes, cotton candy, steak-on-a-stick and other items.
The purchase of a $1 discount wristband will entitle buyers to 50 cents off each concession purchase.
From 1 to 5 p.m., children can pay a $3 admission charge and enjoy activities in the expanded children's area, which will feature bouncing rooms, a tiger in a jungle, tag maze, a giant slide, bouncy boxy, a caterpillar maze, a daisy dinosaur slide, a Mr. Cool booth and the Fun Flush.
At 3 p.m., buses will begin shuttling festival-goers to the Discovery Center from the parking lot of Target Stores at Interstate 40 and Soncy Road. The buses will run until the last person is dropped off, organizers say.
Musicians and dancers will begin performing at 3 p.m. Among the groups scheduled to perform are the Amarillo Jazz Orchestra and the Club Mayfair Dancers.
The Amarillo Symphony will begin its concert at 8 p.m. with a variety of favorites. The performance will be simulcast on radio stations KMML 96.9 FM and KIXZ 940 AM. The second half of the performance will be punctuated by the Grucci fireworks display.
The patron area will open at 6 p.m. The reserved area will include gourmet meal, beverages, premiere seating for the symphony concert and fireworks.
© 2016. All Rights Reserved. | Contact Us

subset: commoncrawl


text:
Companies serving Brunei Darussalam
Current filtering criteriaYou can remove a filter by clicking on the x
Employees number: 1-10 ×
Industry: Construction & Construction Materials ×
Serving: Asia & Middle East ×
Serving: Brunei Darussalam ×
Advanced Cyclone Systems, S. A.
based in Porto, PORTUGAL
Advanced Cyclone Systems, S.A. (ACS) is a company exclusively dedicated to the development and commercialization of high efficiency cyclone systems, worldwide. The company works in a very close cooperation with its clients in order to design custom made cyclone systems that really solve their unmet needs.
Omnitec Design, Inc.
based in Mukilteo, WASHINGTON (USA)
Omnitec Design, Inc. specializes in manufacturing equipment for environmental cleanups, restoration, healthcare facilities, labs, emergency response and many other industries. Omnitec started in 1988 with an innovative, modular design of asbestos abatement equipment and expanded to other hazardous waste and bio-contamination specialty equipment. We introduced light ...
based in Bolzano, ITALY
In 2011 EmiControls starts to manufactures and supplies custom-made solutions for dust control and odor elimination for a wide and diverse range of sectors. Mobile and fixed dust-binding sprayers are as much part of its repertoire as custom-built spray installations and complete dust-control systems. Highly efficient systems are built on experience in nozzle design, ...
based in Nottinghamshire, UNITED KINGDOM
Aireshelta is a world leader in the design, manufacture and supply of specialised inflatable shelters which, because of their sealed beam construction, avoid the problems which complicated pole systems, missing parts and excessive weight can cause when teams are attempting to deploy and assemble shelters in a hurry. Aireshelta has been pioneering shelter technologies and ...
Sustainable | Water | Management | Group
based in Basel, SWITZERLAND
VISION By providing most recent water management related information in a condensed form the Sustainable Water Management Group is intended to serve as unique and leading communication and information platform for concerned stakeholders from industry, science, government and the broad public.MISSION The Sustainable Water Management Group strives to provide interested ...
IBS Engineered Products Ltd
based in Doncaster, UNITED KINGDOM
Founded in 1994, IBS has established itself as one of the worldwide market leaders in temporary demountable and demountable flood protection systems. Our flood protection systems have been used very successfully across the UK & Ireland, mainland Europe, Australia and the USA providing protection of high value assets that are at ever increasing risk due to climate induced ...
Industrial Hygiene Services
based in Vadodara, INDIA
Hazard Management Services [HMS] - A Division of decade young leading & known consulting firm "Industrial Hygiene Services [IHS]†aims to provide quality Health & Safety Consulting Services to it's valuable clients Globally.HMS Division focuses it's services on Indoor Air Quality Programs, Green Building Certification Consulting Services, Hazardous Material ...
based in Harrogate, UNITED KINGDOM
We started trading in 1984 as GraphicAir Systems, manufacturing air filtration cabinets for the education and graphic design markets. The company was incorporated as Widespread Solutions Limited in 1994 and began diversifying into other sectors requiring the filtration and extraction of fumes, dusts, gases and solvents. The BenchVent brand was launched in 2012 as a means ...
Kitagawa America LLC
based in Pompton Lakes, NEW JERSEY (USA)
Kitagawa America is dedicated to delivering gas detection solutions and providing its customers with world class service and technical support. With more than 20 years experience in the gas detection industry, Kitagawa America directs the sales, service and distribution operations for the Kitagawa brand throughout North, Central and South America. Kitagawa America is a ...
based in Vancouver, WASHINGTON (USA)
Spill Control and Drain Protection can be dirty jobs. That's why EnviroMet has our own Mrs. Clean to help you with all the Absorbents, Spill Containment, and drain protection products you need.Need to know how to clean up an oil spill? Check out our oil absorbents. How about chemical spills? Our spill containment pallets and overpack salvage drums will make your clean up ...
WIH Resource Group
based in Phoenix, ARIZONA (USA)
WIH Resource Group provides clients with fully integrated solutions to day to day business challenges, solid waste & recycling issues, as well as transportation and logistical challenges. We offer creative solutions to solve complex business issues and solid waste transportation and disposal challenges for government municipalities, industrial companies, environmental & ...
based in Nairobi, KENYA
TerrCon is Environmental and Social Management Consultancy based in Kenya with a global scope of service provision. TerrCon offers cost effective Environmental and Social Management Solutions that ensure Corporate and Community Sustainability. TerrCon succeeds because we understand our client`s needs, industry standards, community & stakeholder dynamics and use ...
ErCe Ltd. Sti.
based in Ankara, TURKEY
ErCe has founded in 1995 located Ankara. We are manufacturer of Avevo welding fume extraction systems. Our R&D team always works for improve new products according to custpmers demands. Our MSU range mobile systems have cleanable cartridge filters and patent pending dust collection system.
based in Porto, PORTUGAL
Biodiversity Specialists. Founded in January 2011, Floradata is a consulting company specialized in biodiversity, ecology, environment and natural resources, with a client-focused approach. Floradata provides high quality services in a business area underrepresented and with high growing perspectives. Floradata technicians have a 10 year working experience average in ...
Fast Engineering, Ltd.
based in Antrim, NORTHERN IRELAND
Fast Engineering Ltd was established in 1981 by its Managing Director, Seamus Connolly MBE to manufacture FASTANK. FASTANK is a patented liquid storage container for use in a number of sectors including oil and chemical spill clean up, Aid Agency, fire fighting, military, fish-farming, and animal rescue. Today the FASTANK range of tanks and bunds are exported to over 80 ...
Hixon Mfg. & Supply Co.
based in Fort Collins, COLORADO (USA)
Hixon Mfg. & Supply Co. serves professional surveyors and construction companies throughout North America with equipment sales, service and training. We are the largest Leica Geosystems dealer in Colorado and Wyoming. Hixon Mfg. & Supply Co. manufactures prism poles, GPS poles and other specialty equipment. Our retail stores in Fort Collins and Denver, Colorado offer a ...
H2O International, Inc.
based in Deerfield Beach, FLORIDA (USA)
H20 International is a progressive U.S. based company manufacturing and distributing worldwide a full range of water filters and water purifiers for domestic, commercial and industrial applications. As active members of water quality associations, we are aware of the latest developments within the industry. The use of KDF® 55, a patented and NSF listed media along with ...
Barrier Systems, LLC
based in Kula, HAWAII (USA)
The SandMaster Sandbagging System is the only sandbag filling system on the market today that fills, transports, securely closes and places multiple sandbags at the area of need. Capable of creating and placing 15,000-18,000 sandbags in a 24 hour period. It does't matter what you are filling bags for or with, the SandMaster will speed up the process providing more bags in ...
MB America, Inc.
based in Reno, NEVADA (USA)
MB America, Inc. was founded in April 2010 in Reno, Nevada. It is the American branch of MB S.p.A., located in Italy. For MB S.p.A., its inauguration represented the end of a comprehensive market analysis that lasted a couple of years. Later, a process aimed at strengthening the presence of the MB crusher buckets on the American market began. In fact, MB S.p.A. set off ...
Odeon A/S
based in Kgs. Lyngby, DENMARK
The ODEON project was initiated as a cooperation between the Technical University of Denmark (Dpt. of Acoustic Technology) and a group of consulting companies in 1984 with the purpose of providing reliable prediction software for room acoustics. The years invested in the ODEON development has provided a reliable yet easy to use room acoustics prediction software. Today ...
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text:
While serving as physician to the king of Egypt, Dr. Serge Voronoff had noted that the court eunuchs were often sickly and seemed to age very quickly. The testes, he concluded, played an important role in maintaining vigour, and that "possession of active genital glands was the best possible assurance for a long life." In 1918 he believed he made his point when he restored an aging ram's youthful vitality by transplanting the testes of a young lamb. Voronoff upped the ante by transplanting the testes of executed criminals into aging men rich enough to pay for the procedure. But demand soon outstripped supply, and since few young men were willing to part with their precious parts even for rich compensation, Voronoff came up with an alternate scheme. He would transplant bits of chimpanzee and monkey testes onto the genitals of elderly men. Eventually more than a thousand men underwent the monkey gland treatment at the hands of doctors around the world, with the requisite material often being supplied by a monkey farm Voronoff set up on the Italian Riviera.
Dr. Eugen Steinach bought into Voronoff's idea, but thought that the benefits ascribed to transplants could be achieved by an alternate procedure. Damming the seminal canal would stimulate the testes to produce more male hormones! At the time, researchers had determined that that there were two types of tissues in testicles. Seminal tubules produced spermatozoa, but there were are also "Leydig" cells between the tubules, that released sex hormones. Steinach's idea was that the two types of tissues compete for nourishment, and that stifling the sperm producing tissues would boost the production of the sex hormones.
In his book, Sex and Life, Steinach described how his patients "changed from feeble, parched, dribbling drones, to men of vigorous bloom who threw away their glasses, shaved twice a day, dragged loads up to 220 pounds, and even indulged in such youthful follies as buying land in Florida." He believed in his procedure so strongly that he "thrice reactivated himself." It isn't clear what he meant by "thrice" because once the duct is tied off, it's tied off. Whatever improvement Steinach and his patients felt was likely due to wishful thinking, because as we now know, vasectomies do not boost hormonal output by the testes.
Steinach had testimonials galore, including from some very famous people such as. Sigmund Freud who underwent the procedure when he was 67 years old, hoping to improve his "sexuality, his general condition and his capacity for work." William Butler Yeats, the famed writer, was Steinached when he was 69. "It revived my creative power," wrote Yeats in 1937. Apparently in more than one way. The doctor who performed the snip invited a woman half Yeats's age to dinner with the aim of allowing the writer to make a connection and test out his newly embellished virility. It seems the outcome was successful with Yeats publicly reporting on his "second puberty," leading to the Dublin press nicknaming him the "gland old man."
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Top Definition
An extremely dangerous vehicle used to ride down hills. It is basically a children's motorized jeep toy without the motor or brakes. Fun, but stupid. Pronounced (N-viye-ti-cus).
I broke my arm riding Inviticus the other day.
додав JebusIsBack 04 Грудня 2010
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text:
not legal. i smell trouble for some company execs. in fact, this news should be spread. this is a major violation.
stupid short, cover now
how does this make me a short? the insider selling is public knowledge and telling the board that they broke the law by selling on information that wasn't disclosed until the release of the annual report, which came after the insider sells.


text:
Depending on one's perspective, Jeremy Eck walked into a dream or a nightmare when he became the Loyalsock baseball team's new coach three years ago.
The good part in 2010 was that Eck inherited a program that captured a state championship, reached two straight semifinals and won 44 games the previous two seasons. The bad part was the immense pressure Eck faced, replacing highly successful coach Casey Waller and guiding a program into a new decade accustomed to winning at a high level.
Eck embraced the challenge, his players responded and nothing has changed. Loyalsock is still one of the state's best baseball programs and is still winning at a remarkable rate. And today the Lancers play for a shot at the Class AA state championship game.
Loyalsock (20-3) meets District 11 champion Salisbury today at Bloomsburg University in the Eastern Region championship. It is the second time in four years Eck has led the Lancers there.
"As a head coach after four years you want to re-evaluate and see where you stand and see where your program is. I think we're where we need to be," Eck said. "It's exciting but we're not satisfied. As (Montoursville) coach Jim Bergen always told us in football, 'be happy, but not satisfied,' and I've carried that with me my entire life and we tell our boys that."
That mentality has helped Loyalsock become a Class AA power. Loyalsock is the only team which has reached the state's Final 4 in four of the past six seasons. The team's seniors have won 76 games and this is the third time in four years the Lancers have won at least 20 games. It has been one of the best runs by any team in any high school sport.
Fact Box
Salisburg (25-1) vs. Loyalsock (20-3)
Loyalsock facts: The Lancers are playing in their fourth Eastern Final championship since 2008 and are seeking their first state championship appearance since that year. Loyalsock rallied past District 3 champion Delone Catholic for a 9-5 quarterfinal win that stretched from Thursday to Saturday and that began in Pine Grove before being moved to Bloomsburg. The Lancers overcame a 5-1 third-inning deficit and scored five runs in the fifth and sixth innings after the game was resumed Saturday in the fourth. Ethan Moore delivered a big go-ahead, two-run triple in the fifth inning. Right fielder Jimmy Webb went 3 for 4 and scored twice while center fielder Robbie Klein went 1 for 1 and reached base four times. Klein is 3 for 5 in two state games, has reached base six times and has three RBIs. Kyle Datres threw five scoreless innings and struck out six against Delone after throwing 3 1/3 hitless innings in a 6-0 first-round win over Lakeland. Duke-bound sophomore Luke Glavin threw 3 2/3 scoreless innings against Lakeland and is 5-1. He threw 6 1/3 brilliant innings in a 4-3 district quarterfinal win over Towanda and threw a complete-game two-hitter with 13 strikeouts in a 2-1 regular-season game against Danville. Loyalsock has overcome deficits of three and four runs in the postseason and edged Montoursville, 2-1 in the district semifinals when Klein drew a game-winning bases-loaded walk. Bailey Young hit a two-out sixth-inning RBI single in that game. Tommy Baggett was one of the team's top run producers during the regular season and was a HAC-II first-team all-star, along with Datres, Klein and Webb.
Salisbury facts: The Falcons are seeking their second state championship appearance in three seasons and have a good core still together from the team which reached the title game in 2011. They dethroned defending Eastern Region champion Pine Grove in the District 11 semifinals, turning a three-run seventh-inning deficit into a dramatic 6-5 win. Salisbury defeated Neumann-Goretti, 6-2, in eight innings in the opening round of states before holding off Hughesville, 9-5, in Thursday's quarterfinals. The Falcons opened a 3-0 first-inning lead in that game before falling behind 5-4 in the third. They took the lead back in the fifth inning and added three insurance runs in the seventh. Salisbury did a good job finding holes and finished with 11 hits, several with two strikes. Center fielder Brad Vangeli made the play of the game in the bottom of the sixth, throwing the potential tying runner at home with a perfect strike. Justin Aungst and Tyler Cooperman threw well against Hughesville, scattering eight hits. Those two are a combined 16-1. Staff ace Nic Ampietro is 8-0 with a 0.98 ERA and 72 strikeouts. He allowed a season-high five runs against Pine Grove. He allowed one run and scattered seven hits while striking out two in 6 1/3 innings against Neumann-Goretti before Aungst earned the win in relief. Salisbury is collectively hitting .371. Aungst is hitting .483 with three home runs and 34 RBIs. Vangeli, the lead-off hitter is batting .447 while Mason Kresley has a team-high four home runs and 33 RBIs. Right fielder Zach Seitz is 6 for 8 with four RBIs in two state games.
Winner plays: District 7 champion Beaver or District 7 runner-up Quaker Valley
- By CHRIS MASSE
The names of players and coaches have changed over the years but the results have been constant. This consummate winner was born in 2005 when Loyalsock won its first district title. Kory Datres and Nate Hill were the team's top pitchers that year and now are assistant coaches. They were there when the good times started and they are part of a coaching staff that has helped it continue for nearly a decade.
How Loyalsock has built on the tradition this season is a nod to great Lancer teams of the past. The Lancers have been ravaged by injuries and other issues, but have never buckled. Nothing has deterred Loyalsock in its pursuit of the ultimate goal and this year's team has proven the program produces players who are as tough as they are talented.
"We're all tweaked up a little bit but that stuff happens in the game," shortstop/pitcher Kyle Datres said. "You have to fight through it and make the most of it."
"We knew coming in that we were built to make a run. Some things haven't gone our way all season with some injuries and the other stuff, but our kids believe and they have heart," Eck said. "We talk about Lancer pride all the time and doing things the right way. You do things the right way and everything else will take care of itself."
Nothing has come easy this season, but Loyalsock has repeatedly found a way to flourish. It rallied to win a fifth straight HAC-II championship and then won consecutive one-run district playoff thrillers over Towanda and Montoursville while earning a fifth state tournament berth in six seasons. The Lancers erased a four-run seventh-inning deficit in the district final, but lost a 7-5, nine-inning heartbreaker to Hughesville.
The loss stung and forced Loyalsock to travel a difficult road to the Final 4, starting in the backyard of District 2 champion Lakeland. Again, the Lancers thrived when others might have broken. Loyalsock snapped Lakeland's 16-game winning streak and blanked the Chiefs 6-0. They then overcame a four-run deficit in a quarterfinal that covered three days and two locations, downing District 3 champion Delone Catholic, 9-5.
The more difficult the task, the better Loyalsock seems to play.
"We had 12 outs (Saturday) to find a way and we found a way," senior infielder Ethan Moore said after hitting the go-ahead, two-run triple. "We knew we had four innings to do something, four innings to get baserunners and have people come through and that's what we did. It was another team effort and a big win."
Loyalsock has collected a lot of those over the years. Going back to 2008, Loyalsock has won four district championships and 10 state playoff games. No District 4 team has matched that resume and now the Lancers have a shot to enhance it.
Competing at a school that produces successful teams in just about every sport makes it tough to stand out sometimes. And yet this team, this program does. Whether under Waller or Eck, whether healthy or banged up, Loyalsock baseball has set the standard at its school.
"That just shows who we are," center fielder Robbie Klein said. "We're just a tough team."
Now the Lancers want to be the state's best team.
"They've been in big games. They've been in World Series, they've been in state championships in Little League but none of that compares to playing for a state championship in high school," Eck said. "To be able to walk out at (Penn State's) Medlar Park with your community behind you and a state title on the line ... there's nothing like it."
Today's game will be yet another tough one. They all are at this point. But that is what Loyalsock likes. That is what makes these games so fun.
"I'm extremely proud of these guys and a little emotional too because I'm drained, I'm tired, but it's great," Eck said. "You bust your butt this long and you give everything you have."
That is the Loyalsock way.


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Nationstar Mortgage posts lower 1Q profit and acquires a real estate services company
Lewisville-based Nationstar Mortgage posted a profit of $23.7 million, or 27 cents per share, in the first quarter.
That's down from a net income of $62.6 million, or 70 cents per share, from a year ago.
Separately, the mortgage servicing company said today that it acquired Real Estate Digital for $18 million in cash. The Aliso Viejo, Calif.-based RED provides online marketing, data, transaction management and digital media solutions.
Nationstar's existing real estate services business Solutionstar will oversee RED's 120 employees.
The acquisition represents the latest move by Nationstar to diversify its revenue and product offerings to customers. Nationstar provides direct-to-consumer mortgages, loan servicing and other real estate-related services, like title settlement and appraisal services.
Nationstar CEO Jay Bray said the RED transaction acquisition "accelerates our plan to offer a fully integrated digital marketplace that provides end-to-end services for every aspect of a real estate transaction."
Total revenue in the quarter was $469.6 million, up from $431 million a year ago.
The company, however, poster higher expenses from a year ago.
The company said its origination business returned to profitability in the first quarter. Nationstar funded $4.7 billion in loans in the quarter.
Nationstar's servicing portfolio totaled $384 billion in unpaid principal balance.


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The City of National City established a Housing Inspection Program. The purpose of this program is to address the issue of substandard properties, promote greater compliance with health and safety standards and preserve the quality of National City's neighborhoods and available housing.
The program achieves compliance of health, safety and welfare code violations in/on residential properties that are:
The Housing Inspection Program is designed to focus on single family dwelling, duplexes, and apartment complexes. The Program's objective is to identify and correct substandard housing conditions through voluntary compliance from landlords/property owners. This will ensure that residential properties meet minimum health and safety standards. It is the City's intent to educate property owners of the need for preventative maintenance to ensure residential properties meet the minimum health and safety standards. In many instances, the owner/tenant may be unaware of the applicable regulations.
Housing Inspectors will perform inspections to identify inadequate sanitation, structural hazardous, hazardous electrical, plumbing, or heating systems, faulty weather protection, fire hazards, inadequate exits, and unhealthy or unsanitary premises. The identification and correction of substandard housing helps property owners improve their property and neighborhood. This will also ensure that families are living in safe and decent homes.
For Further Information
Housing, Grants, and Asset Management Department MLK Jr. Community Center140 E 12th Street, National City, CA 91950 Telephone Number: (619) 336-4301Email: email@example.com
City Hall, 1243 National City Blvd, National City, California 91950 | Phone: (619) 336-4241 Fax: (619) 336-4239
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Upper Dauphin figured to be a nifty diversion for the Susquenita baseball team that is immediately focused on winning the Mid-Penn Capital title.
Nifty, but difficult.
On April 14, the Blackhawks hosted the Trojans, who will welcome Susquenita into the Tri-Valley League next year.
For Blackhawk skipper Bryon Wilson, who spent five years tangling with UDA when he was at Newport, nothing has changed.
The Trojans are still a tough out.
Upper Dauphin starter Mac Ney tamed Wilson's batting order over seven gritty innings and UDA punched up single runs in the second and fourth innings to hand the Blackhawks their second loss of the season.
"That's a nice team," said Wilson, whose team fell to 7-2 overall but, at 5-0, holds a two-game lead on West Perry in the Capital pennant chase. "They always have a good team up there."
Blackhawk senior John Daum was nearly as effective as Ney. The right-hander tossed a complete-game nine-hitter with two strikeouts and a walk.
The Trojans bunched four hits together in the second to take the lead. Daum needed a ground ball back to the mound to end the threat with the bases loaded.
The Trojans tacked on a second run in the fourth when the Blackhawks committed a two-out error on an infield grounder.
"Daum threw well," Wilson said. "He was, literally, a decent catch in the outfield and a ground ball from pitching a shutout."
Ney also had to pitch under stress.
Blackhawk leadoff hitter Evan walked to open the first and got as far as third base. Ney fanned two Blackhawks and got a grounder to first to escape trouble.
Shane Smith singled with one out in the second and moved up on a passed ball, but got no farther.
After working a 1-2-3 third, Ney walked Daum to start the fourth, but Jordan Baker hit into a 4-6-3 double play and Jake Nace was left at first after singling with two outs.
"Jordan hit the ball on the screws, but right at their second baseman. A perfect double play ball," Wilson said. "That's the way the game goes sometimes."
The Blackhawks had another chance in the sixth, but wasted Jeremy Sultzaberger's two-out double.
Battling to the end, Wilson's crew mounted a seventh-inning bid for the win.
Smith laced his second single of the game to open the frame. Daum popped to short for the first out, then Baker lined a ball to right that, a foot, or so either way, might have gone for extra bases and scored Smith.
"It was a screamer ... right at him. He didn't even budge," Wilson explained. "Twice, Jordan hit the ball hard and got nothing out of it.
"Ney threw a nice game, but we had our chances. We just couldn't get the big hit."
This week, the Blackhawks' pursuit of the Capital resumes in earnest. They were scheduled to host East Pennsboro on April 21, take on West Perry at Metro Bank Park the next night, then travel to Camp Hill on the 24th. Looming ahead is a rugged slate that includes second games with Camp Hill, Northern, East Penn and Trinity.
"We've got three weeks and 11 games to play. We won't have many nights off," Wilson said. "We could hit a little more, but I like how we're playing right now."


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ST. LOUIS (AP) - Marc Bulger will get another start for the St. Louis Rams, more because of concerns for Kurt Warner's broken pinkie than the backup's outstanding play.
Coach Mike Martz said Monday he'll stick with Bulger, but Warner will be the backup for the Monday night game against the Chicago Bears and will definitely return as the starter the following week.
He said the decision was mostly based on doctors' opinions that Warner, the two-time NFL MVP, could possibly re-injure the finger. Martz also is concerned Warner is not yet back in football shape.
"After talking to the doctors, they were in agreement," Martz said. "It's just too risky to start him and not get that finger banged around. This will give him that extra week to heal."
Warner was apparently unaware of the decision about 10 minutes before Martz announced it during a news conference. Last week, Warner said several times that he planned to make his return against the Bears, but Monday he took a diplomatic approach.
"This is all about our team, it's not about two individuals," Warner said. "Everybody wants to make it, 'This is Marc, this is Kurt,' and so be it.
"But I think everybody that knows anything about football can see this is a team effort."
Bulger is the popular choice in St. Louis for the time being after leading the Rams to four straight victories, while Warner was 0-4. But the going has definitely been easier.
With Warner, the Rams lost to some of the better defenses in the NFL: the Broncos (2), Buccaneers (1), Giants (8) and Cowboys (5). During Bulger's run, the Rams have beaten the Raiders (23), Seahawks (26), Cardinals (25) and Chargers (21).
Martz said if Warner was healthy, he would start.
"If he's 100 percent, it's a real easy decision for me," Martz said. "Kurt's our quarterback, guys, I'll tell you that again."
The Rams (4-5) might not have Marshall Faulk, either, for next week's game. Martz said the All-Pro running back would be listed as questionable with a strained tendon on the bottom of his right foot.
"Will he be ready this week? Probably not," Martz said. "We'll be very pessimistic."
Warner, who has missed five games, resumed throwing last Thursday and tossed several 40-yarders before the Rams' game against San Diego on Sunday. On Monday, he said he threw as long as 55 yards.
Warner said his finger is feeling better every day, and he's scheduled to start taking snaps again this week. Martz said Bulger would get the bulk of the practice reps, but said Warner would run some of the scout-team offense.
Bulger had a team-record 36 completions for 453 yards - fourth-best in franchise history - in Sunday's 28-24 come-from-behind victory over the Chargers. Warner's best is 441 yards in the 2000 opener against the Broncos.
Bulger threw two of his four touchdown passes in the final 3:06, both to Isaac Bruce. This is the first week he's thrown enough passes to qualify among the league leaders and he's first with a 107.4 passing rating, well ahead of runner-up Brett Favre's 101.7.
Faulk was held to 72 total yards - 36 rushing and 36 receiving - before leaving in the fourth quarter of Sunday's game.
He was optimistic after the game, and Martz said Faulk would have input into whether he would play.
"If he's not ready, he'll tell me he's not ready," Martz said. "I have complete trust in his judgment."
Lamar Gordon, a rookie, finished Sunday's game and had one carry for 9 yards and caught four passes for 27 yards. The Rams also have Trung Canidate, a first-round pick in 2000.
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I spoke with my friend Lisa last week, who is due to have her third child in January. Before having children, Lisa was a first grade teacher. After she... More.
Discovering Mystery
December 31, 2009 | 1:08 pm
This week, on our winter vacation, my husband, Tal, made a list of supplies before we went out to the market. My five-year-old son Jeremy wanted to get... More.


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Things goes horribly wrong about three-quarters of the way through Danny Boyle's "Sunshine," a sci-fi thriller from the man so revered for "Trainspotting," among other things.
That's when the monster emerges and starts chasing people. Okay, it's not exactly a monster per se', but it's close enough. It's the same thing that every other sci-fi movie has used to generate false tension. It's a lame idea. It's been used over and over again. I mean, c'mon, could we not think of something else? It's so fucking lame it makes me sick.
Prior to the monster, Boyle actually tries to explore the machinations of a story that finds the Icarus II traveling 93 million miles to restart our sun. Seven years prior, the Icarus I made the same trip, but disappeared. The crew of the Icarus II is a multi-national group including Captain Kaneda (Hiroyuki Sanada), physicist Capa (Cillian Murphy), staff shrink Searle (Cliff Curtis), Corazon (Michelle Yeoh), Cassie (Rose Byrne), Trey (Benedict Wong), Mace (Chris Evans) and Harvey (Troy Garity). Oh yeah, there's also the voice of Icarus (Chipo Chung), reminding us that the thinking ship could go rogue at any moment. Quite frankly, I thought it was a miracle that we weren't treated to that little cliché as well given the number of times it's happened in other sci-fi films.
Given the basic plot of the story, there's a lot to explore, but Boyle and screenwriter Alex ("28 Days Later") Garland lose their nerve. They're trying to make their movie some kind of cross between "2001" and "Alien." Oh hell, they don't just lose their nerve; their balls fall off and roll into the sewer.
There are interesting elements such as how Searle helps and doesn't help the others and what the effects of deep space travel are on human beings. There's also the effect on the crew of saving the human race. Interpersonal relationships are barely explored. Corazon has some weird relationship with her plants that we only see when tragedy strikes. Basically, there's enough raw material here to create tension without resorting to the "monster in the closet" scenario, which is the lowest form of plot resolution there is. It's fucking lazy. It's fucking annoying. It ruins virtually any film that employs it.
It ruined this one.
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Product Information
J.R. Watkins Hand Soap Foam Alo And Green Tea - 9 Fl Oz -Pack of 6
The moisturizing foam in our premium hand soaps gently cleanses the skin while our signature fragrances leave hands smelling fresh.9 fl oz/266mLGently moisturizesFragranced with essential oils (Note: This Product Description Is Informational Only. Always Check The Actual Product Label In Your Possession For The Most Accurate Ingredient Information Before Use. For Any Health Or Dietary Related Matter Always Consult Your Doctor Before Use.)UPC: 818570008452 U
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Montreal's top draft pick Blake Smith celebrated his birthday on MLS Draft Day...and yes now that he's a pro soccer player he picked up the tab at his own family party.
Now he's moving to Montreal and takes some comfort in the fact he knows Impact captain Davy Arnaud.
"I trained with him in Kansas City while he was still their captain and he's the cousin of one of my former teammates at New Mexico so I'm excited to get their and play with him and those guys," Smith said in a Friday morning 1-on-1 interview from his home in Boerne, Texas, a rural community outside of San Antonio.
Check out some of Blake Smith's highlights and enjoy the cartwheels and flips.
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The Grill
Surrounded by dramatic skyline panoramas, The Grill restaurant features an impressive live cooking station, offering up robust international flavours as well as a charcoal grill. Try a delicious variety of meat and fish all cooked over charcoal for that genuine, backyard barbecue taste.
Opening hours
Daily from 18:00-23:00
contact us
Tel: +420 261 191 103
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News Archives of November 2012
November 29, 2012Musicians with Upstate's therapeutic music program set to play for patients
Six local musicians, including a former clarinetist, on the cusp of being the first to be certified as music practitioners from Upstate will begin playing for patients all across CNY as part of the program's final requirements.
November 28, 2012December Radiothon to benefit pediatric patients
Listeners to ClearChannel's Radiothon for Kids can benefit Upstate Golisano Children's Hospital's during three-day program that features interviews with patients and their families, physician and other children's hospital staff members.
November 28, 2012Upstate launches Meatless Mondays program
As part of its wellness programming, Upstate Medical University has instituted "Meatless Mondays," where the university dining centers and cafe will highlight a meatless entree, such as broccoli tofu stir-fry and brown rice, every Monday. Meatless options are available every day at Upstate, but wellness planners say highlighting the meatless menu can help promote healthy eating. Syracuse University helped launch the Meatless Monday idea in the Syracuse area.
November 16, 2012Upstate names 23 as student ambassadors
Student ambassadors, selected from the university's four colleges — Graduate Studies, Health Professions, Medicine and Nursing — serve as goodwill ambassadors representing Upstate at various community and campus events.
November 14, 2012Upstate holds Lung Cancer Candlelight Vigil Nov. 13
Paper luminaries decorate the entrance of Upstate University Hospital as part of the Lung Cancer Candlelight Vigil, held Nov 13. Lung cancer kills more people that any other cancer. Upstate has launched a new weapon in the fight against lung cancer, a comprehensive lung cancer screening program that detects small tumors, allow doctors to begin [...]
November 14, 2012Two breast surgeons join Upstate's Community Campus
Drs. Greco and Keeney join Upstate University Hospital's Community Campus and will work to treat a range of conditions from cancer to genetic testing to lactation issues.
November 14, 2012CNY Community Foundation awards $100,000 to Upstate Cancer Center
Funds have been designated for the construction of an infusion playroom at the Center for Children's Cancer and Blood Disorders to be housed in the new Upstate Cancer Center.
November 13, 2012Upstate's Margaret L. Williams Developmental Evaluation Center celebrates 30 years
Puppeteers from the Open Hand Theater perform during the 30th anniversary celebration of the Upstate Medical University's Margaret L. Williams Developmental Evaluation Center Nov. 3. The center has provided diagnosis and treatment for autism and other disorders since 1972.
November 13, 2012Upstate celebrates Great American Smoke Out Nov. 15
Upstate employee survey shows employee smoking has dropped 7 percent since 2002. Cold turkey sandwiches are on the menu for employees who quit smoking for the Great American Smoke Out.
November 2, 2012Upstate Golisano Children's Hospital hosts Halloween parade for patients and their families
Upstate Golisano Children's Hospital's Child Life Program hosted a Halloween parade for patients and their families. The event is an annual tradition at the children's hospital. Staff volunteer their time and goodies to help create a sense of routine and normalcy for patients who unable to trick-or-treat outside of the hospital. Nurses like Jenelle Vargulick, 11G, escort patients through a maze of treat stops in the children's hospital "neighborhood" created by our own child life specialists. It's a certain bright spot for patients like Shyea, pictured above. To see the album, visit https://www.facebook.com/UpstateGCH.


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March 18, 2004, 02:57 AM
I really like the quills shirt but I'm having trouble deciding which size to get. I'm 5'8" 180 pounds and usally have to try on the specific shirt before I know whether to get a large or a medium. Any help from similar sized people? Thanks.