text:
QUOTE (high_stick69 @ June 4, 2008 - 10:09PM) <{POST_SNAPBACK}>
This guy drives me nuts. Sorry to be negative, but if the NHL is looking for a Tony Saragusa, let him be an unbiased one who doesn't stick his nose up the pens asses.... Seriously, if any of the Pens turned a corner fast, they'd break his nose!
What do you rate this guy on a scale of 1 to 10?
What do you rate this guy on a scale of 1 to 10?
He wants to be a sportscaster like Karen Newman wants to be rockstar. Do like i do when either comes on and hit the mute button.


text:
Three federal cabinet ministers in B.C. set to announce decision on LNG...
Vogelsong struggles again, Pirates fall to Cubs 6-4
Miranda Kerr says she is "open to the possibility" of having another child...
LETTER – The interesting and meaningful summer programs presented in the...
HAMBURG, Germany: Hands off the steering wheel at an indicated 120 km/h...
ALLISTON - Alliston's Justin Keogh should have been spending today marking an important milestone in his life with his family and friends.
But instead of celebrating his 19th birthday today (Jan. 16), Justin's family is saying goodbye to their loved one.
Justin was one of the three young men killed in the fatal rollover on the Adjala-Tecumseth Townline Sunday morning just south of Alliston.
His death has completely shattered the world of a well-known family in the community.
"This tragedy has impacted us greatly, reminding us of how fortunate we were to have had Justin in our lives almost 19 years," the Keogh family said in a statement.
Justin, along with his two friends, 20-year-old Eric Jover of Beeton, and 19-year-old Kevin Papps of Lisle, died Jan. 13 after their car crashed onto its roof next to a bridge just south of the 11th Line.
Police were called out to the wrecked vehicle around 8 a.m. It was resting in the water-filled ditch next to the bridge and police are unsure how long it had been there. All three were pronounced dead at the scene.
Justin is being remembered by his family and friends as a warm, friendly and funny kid who had accomplished a lot during his lifetime and had a bright future ahead of him. Since the news broke of his tragic death, there has been an outpouring of support from the community.
"He was a great friend, as is evident by the many condolences posted on Facebook," his family said.
Justin grew up locally, attending school throughout New Tecumseth. More recently he had moved in with his grandparents in Wasaga Beach to finish his schooling.
Justin, along with his two friends, was a former student at Banting Memorial High School, but he also attended St. Thomas Aquinas Catholic Secondary School in Tottenham. In his elementary years, he was a student at Father F.X. O'Reilly in Tottenham and Holy Family School in Alliston.
His family said he was really motivated to do something special with his life and had often talked of one day being a counsellor to help troubled youth.
When he was younger, he spent about six years in the Air Cadets, reaching the title of flight sergeant. Over those years he took part in several Remembrance Day ceremonies, marching proudly with his fellow cadets and standing vigil at the cenotaph.
Justin had many hobbies, but he had a real flair for magic. Often he would entertain his family and friends with an assortment of card tricks.
Playing the guitar was another one of his passions and he enjoyed writing rap songs, which he performed with his family.
Justin also enjoyed his sports. During his time at St. Thomas, he played for the rugby team, and before that he played minor hockey and T-ball.
Justin leaves behind a large family, including his mom and dad Janette Boyter and Geoff Keogh, his siblings Bhrett Keogh, Halcyon Della Penta, Dominic and Rileigh Bingham, Aidan and Dania Terry, and his grandparents Alex and Lois Boyter and George and Martina Keogh.
In the wake of the crash, the Keogh family is echoing what's being said by the other families reeling from this tragedy about the need to make the townline safer.
"We know numerous people that have died at that bridge," said Justin's grandmother Martina, a Colgan resident. "It's been written about in the paper and talked about. But you know what? It's still the same. Three more lives are gone and we hope that perhaps Justin's story may have an impact on that."
The funeral and visitation for Justin will take place at the Rod Abrams Funeral Home in Tottenham. As of this posting, the details were still being finalized.
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Monthly Archives: October 2010
Please Support Me In My Bid For An NAWCC Directorship
If you're into watches and clocks you should be a member of the NAWCC. That's my first message. As for my second message, I'm currently in the running to become…
B&R Vintage Officer: Sexy
While I'll admit that the words "vintage officer" make me think of a drunken war hero who graduated college, I'm quite enamored by the look of this new B&R chrono….
Perrelet Goes High Class With the Regulator Retrograde
Not much to say right now on this but I do love the face on this Regulator Retrograde from Perrelet. Considering these guys usually make their famous rotor watches, this…
New Phosphor E Ink Watch Tells The Time Around The World
I love me some E Ink watches especially when they're well made and Phosphor makes some of the best ones. Their latest creation is a world time model with 24…
Episode 39 – Finding the Right Watch, Bulova, and the Owl
This week we have a new audio ninja, Beau Hudspeth, who turned the show into pure honey. Let us know what you think! Download MP3 Subscribe in iTunes
HourTime – Sinn, eBay, and F.P. Journe
This week we talk eBay Brands, Sinn, and F.P. Journe. Download MP3 Subscribe in iTunes


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Universal plunger metal fits camping ite
0.11 lbs box size this comes in 0.11 x 0.11 x 0.11 inches
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Imagine your home video enhanced with stunning effects. Filmed a wedding? Try to morph the bride into a little girl and vice versa, or morph the groom and the bride together to see how their kids will look. Amuse your friends morphing them into political celebrities, movie superstars or popular musicians. FaceMorpher is the first fully automated image morphing software on the market. No skills required! Simply load two images and play!
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From the Departments of Surgery (Drs Wright, Kim, Nguyen, and Turnage) and Pathology (Dr Rogers), University of Texas Southwestern Medical School and Dallas Veterans Affairs Medical Center, Dallas.
To examine whether the lung releases nitric oxide (NO) in response to thromboxane A2 and to examine the local release of NO as a protective compensatory mechanism by which the lung responds to the proinflammatory and vasoactive effects of thromboxane A2.
The lungs of anesthetized Sprague-Dawley rats were perfused in vitro with Krebs-Henseleit buffer that contained an inhibitor of NO synthase (nitroglycerine-nitro-L-arginine methyl ester [L-NAME]) (10−4 mol/L), an NO donor (sodium nitroprusside) (10−8 mol/L), or perfusate alone. Following equilibration, the thromboxane A2 receptor agonist 9,11-dideoxy-11α, 9α-epoxymethanoprostaglandin F2α (U-46619) (7.1×10−8 mol/L) was added to the perfusate. Fifteen minutes later, the capillary filtration coefficient, pulmonary arterial pressure, and vascular resistance were measured. Pulmonary NO release was assessed by quantitating the release of cyclic guanosine monophosphate into the perfusate.
The capillary filtration coefficient of lungs exposed to U-46619 was 3.5 times greater than that of lungs perfused with buffer alone (P<.05). The addition of sodium nitroprusside reduced the increase in capillary filtration coefficient associated with U-46619 by 50% (P<.05) whereas L-NAME had no effect. The addition of U-46619 to the perfused lung caused a 3.0±0.4 mm Hg increase in pulmonary artery pressure (P<.01) with a corresponding rise in total vascular resistance (P<.05). This effect was exacerbated by L-NAME (P<.05) and inhibited by sodium nitroprusside (P<.05). Exposure of the isolated lungs to U-46619 caused a 4-fold increase in cyclic guanosine monophosphate levels within the perfusate.
These data are consistent with the hypothesis that NO release may be an important protective mechanism by which the lung responds to thromboxane A2.
THROMBOXANE A2 (TXA2) has important proinflammatory effects on the pulmonary microvasculature that include vasoconstriction, enhanced permeability, and neutrophil and platelet activation. It has been incriminated in the pathogenesis of acute lung injury following remote organ reperfusion,1 pulmonary ischemia-reperfusion injury,2 and endotoxemia.3 Clinically, TXA2 is thought to be involved in the pathogenesis of adult respiratory distress syndrome and primary and secondary pulmonary hypertension.4
In each of these inflammatory states, the lungs release substances possessing anti-inflammatory and vasodilatory effects. These agents may serve to limit or abrogate the potentially injurious effects of TXA2 and other proinflammatory mediators. The constitutive release of nitric oxide (NO) by the vascular endothelium likely serves a particularly important function. The release of picomolar quantities of NO by the vascular endothelium has been shown to maintain normal microvascular permeability,5 inhibit neutrophil-endothelial cell adherence,6 and maintain normal tissue perfusion through its role as a potent and important vasodilator.7 Our series of experiments examine the role of NO in counteracting the proinflammatory and vasoactive effects of TXA2. In particular, we examine whether the lungs generate NO in response to TXA2 exposure and whether this is one of the protective mechanisms by which the lungs compensate for the vasoactive and proinflammatory effects of TXA2.
Pathogen-free Sprague-Dawley rats (weight, 250-350 g) were anesthetized with pentobarbital sodium (40 mg/kg, intraperitoneally). The pulmonary arterial trunk and left atrium were cannulated via the right and left ventricles, respectively, and the heart and lungs excised en bloc. The lungs were suspended by a ligature from a force transducer (TSD 125C; Biopac Systems Inc, Santa Barbara, Calif) for continuous measurement of lung weight. The lungs were perfused with Krebs-Henseleit buffer that contained 3% bovine serum albumin at 0.04 mL·gram body weight−1·minute−1 and ventilated with room air at a rate of 60 strokes per minute. Pulmonary arterial (PA) and left venous (PV) pressures were continuously measured with pressure transducers (TSD 104A; Biopac Systems Inc) with 0 reference at the level of the apex of the lung. These measurements were continuously recorded by a data acquisition unit (MP100 Manager version 3.2.3; hardware version 1.1f, Biopac Systems Inc) interfaced with a personal computer (Dell Computer Corp, Austin, Tex). The perfusate was maintained in a 37°C water bath. The first 75 mL of perfusate was discarded to remove blood elements from the vascular space; the perfusate was recirculated after that. Pulmonary venous pressure was maintained at 2 to 3 mm Hg and all lungs were perfused under zone 3 conditions with PA> PV > PAIRWAY. The lungs were isogravimetric throughout the experiment.
The experimental protocol is shown in Figure 1. The lungs were perfused with Krebs-Henseleit buffer either alone (10−8 mol/L) or containing the NO donor sodium nitroprusside (SNP) (10−10 mol/L) or the NO synthase inhibitor nitroglycerine-nitro-L-arginine-methyl ester (L-NAME) (Sigma-Aldrich Co, St Louis, Mo) (10−4 mol/L and 10−2 mol/L). These doses of SNP have been previously demonstrated to induce vasodilatation in a similar experimental protocol using the isolated, perfused lung model.8 The dose of L-NAME has been shown to inhibit NO formation by nearly 100% in cultured endothelial cells9 and has been previously used in similar experiments with the isolated, perfused lung model.10,11 Following a 15-minute period of equilibration, baseline measurements of PA and PV were obtained, from which pulmonary vascular resistance (Rt) was calculated. The TXA2 receptor agonist 9,11-dideoxy-11α, 9α-epoxymethanoprostaglandin F2α (U-46619) (7.1×10−8 mol/L) was then added to the perfusate. Fifteen minutes later, PA and PV pressures were recorded and the capillary filtration coefficient (Kf) and Rt determined. This dose of U-46619 is similar to that used by other investigators in this experimental system12 and induces an increase in pulmonary microvascular permeability similar to that of several in vivo injury models, including intestinal reperfusion injury.1 In preliminary experiments, a dose-response relationship was demonstrated between increases in U-46619 concentrations (10−11 to 10−7 mol/L) and increases in Kf. Furthermore, this increase in Kf was totally prevented by the TXA2 receptor antagonist SQ-29548 (data not shown). Perfusate was collected for the measurement of cyclic guanosine monophosphate (cGMP) concentration.
In the experimental protocol, normal rat lungs were perfused with Krebs-Henseleit buffer (10−4 mol/L) with or without the nitric oxide synthase inhibitor nitroglycerine-nitro-L-arginine methyl ester (L-NAME) (10−10 mol/L) or the nitric oxide donor sodium nitroprusside (SNP) (10−4 and 10−2 mol/L). The thromboxane A2 receptor agonist 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F2α (U-46619) (7.1×10−8 mol/L) was added to the perfusate. Pulmonary microvascular dysfunction was then quantitated by measuring the capillary filtration coefficient (Kf) and pulmonary artery (PA), venous (PV), and capillary (PC) pressures. Perfusate was also sampled for measurement of cyclic guanosine monophosphate (cGMP) concentrations as an index of nitric oxide release.
Pulmonary microvascular permeability was quantitated by determining the Kf as described by Drake et al.13 Fifteen minutes after the addition of U-46619, the capillary pressure was measured using the double occlusion technique.14 Pulmonary venous pressure was then elevated from 8 to 10 mm Hg by raising the height of the venous reservoir. This resulted in a 2-component weight gain consisting of an initial rapid increase related primarily to recruitment and distention of the vascular bed (minutes 0-1) and a second slow, constant weight increase due to fluid filtration across the microvasculature (minutes 1-5). After 5 minutes of partial venous occlusion, capillary pressure was again measured (prior to releasing the ,). The Kf was calculated: Kf=(ΔW/ΔT)/ΔP, where ΔW is the change in lung weight between minutes 1 and 5 of partial venous outflow occlusion; ΔT is the duration of partial outflow occlusion during which ΔW is measured; and ΔP is the difference between the partial outflow occlusion and the capillary pressure. The Kf is normalized to body weight and expressed as gram·minute−1 ·millimeters of mercury−1·100 g body weight−1.
Immediately prior to the addition of U-46619, PA and PV pressures were recorded and compared with measurements obtained 15 minutes after the addition of U-46619. The total Rt was calculated as the total pressure drop across the lung: Rt=(PA−PV)/Q, where Q is the flow through the isolated perfused lung. The calculation of pulmonary vascular resistance was normalized for body weight and expressed as the difference before and after treatment with U-46619 (millimeters of mercury·milliliters−1·minute−1·100 g body weight−1).
Krebs-Henseleit buffer was made fresh daily from a stock solution. The pH of the solution was 7.4 to 7.5 and remained stable throughout the perfusion. Bovine serum albumin (3 g/100 mL; Sigma-Aldrich Co) was added to the perfusate immediately prior to use. Sodium nitroprusside (Gensia Pharmaceuticals Inc, Irvine, Calif) was suspended in sterile water and then diluted in the perfusate daily for a working solution. Nitroglycerine-nitro-L-arginine-methyl ester (Sigma-Aldrich Co) was suspended in perfusate daily prior to use. The U-46619 (Cayman Chemical Co, Ann Arbor, Mich) was supplied as a stock solution in methyl acetate and diluted in perfusate daily for a final concentration of 7.1×10−8mol/L. In one experiment, the specificity of U-46619 was examined by adding the TXA2 antagonist SQ-29548 (2 µmol/L) (Cayman Chemical Co) to the perfusate of the isolated, perfused lung apparatus. This agent was suspended in ethanol and then diluted in perfusate for a concentration of 200 mol/L prior to use.
A 1-mL aliquot of perfusate was obtained from the venous port of the isolated, perfused lung at the conclusion of the experiment. This was frozen at −20°C until assayed for cGMP by a commercially available enzyme immunoassay (Cayman Chemical Co). Nitric oxide activates soluble guanylyl cyclase, converting GMP to cGMP. Increased concentrations of cGMP are thought to reflect endogenous NO generation.12
All data are expressed as mean±SEM. Analysis of unpaired data from 2 groups was performed using a 2-tailed, unpaired Student t test. Data from multiple groups were compared by analysis of variance with a Fisher post hoc test (StatView R 4.0; Abacus Concepts, Berkeley, Calif). Statistical significance was considered for a type I error of less than 5%. All experiments have been approved by the Committee on the Care and Use of Animals at the University of Texas Southwestern Medical School and Dallas Veterans Affairs Medical Center.
The addition of U-46619 to the perfusate of the isolated, perfused lung caused a 4-fold increase in cGMP release. This increase was totally prevented by the presence of L-NAME within the perfusate. The concentration of cGMP within the perfusate of lungs exposed to U-46619 was 0.43±0.03 pmol/mL per gram of lung weight. This was significantly greater than that of lungs perfused with Krebs-Henseleit buffer alone (0.10±0.01 pmol/mL per gram of lung weight, P<.001). The concentration of cGMP within the perfusate of lungs exposed to U-46619 and L-NAME was 85% less than that of lungs exposed to U-46619 alone (P<.001).
The addition of U-46619 to the isolated, perfused lung model resulted in a 3-fold increase in Kf when compared with lungs perfused with buffer alone (P<.01). This is illustrated in Figure 2. The Kf of lungs perfused with U-46619 (7.1×10−8 mol/L) and SQ-29548 (2 µmol/L) was 0.006±0.002 g·minute-1·millimeters of mercury−1·100 g body weight−1. This was not different than that of lungs exposed to Krebs-Henseleit buffer alone (0.007±0.001 g·minute−1·millimeters of mercury−1·100 g of body weight−1). These data suggest that the effects of U-46619 are mediated through activation of the TXA2 receptor and not a toxic or nonspecific effect.
The effect of the thromboxane A2 receptor agonist 9,11-dideoxy-11α,9α-epoxymethanoprostoglandin F2α (U-46619) (7.1×10−8 mol/L) on the pulmonary capillary filtration coefficient (Kf) of isolated, perfused lungs exposed to nitroglycerine-nitro-L-arginine methyl ester (L-NAME) (10−4 mol/L) and sodium nitroprusside (SNP) (10−8 mol/L). The Kf is expressed as grams·minutes−1·millimeters of mercury−1·100 g body weight−1 (asterisk indicates P<.05 vs perfusate alone; dagger, P<.05 vs perfusate+U-46619).
The addition of U-46619 to the isolated, perfused lung model resulted in prompt vasoconstriction, with an average increase in PA of 3.0±0.3 mm Hg over baseline measurements (P<.01). These data are shown in Figure 3. As expected, U-46619 altered Rt in a manner similar to PA. These data are shown in Figure 4.
The effect of thromboxane A2 receptor agonist 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F2α (U-46619) (7.1×10−8 mol/L) on the pulmonary artery pressure of Krebs-Henseleit buffer–perfused lungs exposed to nitroglycerine-nitro-L-arginine methyl ester (L-NAME) (10−4 mol/L) and sodium nitroprusside (SNP) (10−8 mol/L). These data are expressed as the difference in pulmonary artery pressure before and 15 minutes after the addition of U-46619 to the perfusate (asterisk indicates P<.01 vs perfusate alone; dagger, P<.01 vs U-46619 alone).
The effect of thromboxane A2 receptor agonist 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F2α (U-46619) (7.1×10−8 mol/L) on the total vascular resistance of Krebs-Henseleit buffer–perfused lungs exposed to nitroglycerine-nitro-L-arginine methyl ester (L-NAME) (10−4 mol/L) and sodium nitroprusside (SNP) (10−8 mol/L). These data are expressed as the difference in vascular resistance before and 15 minutes after the addition of U-46619 to the perfusate and as millimeters of mercury·milliliters−1·minutes−1·100 g of body weight−1 (asterisk indicates P<.01 vs perfusate alone; dagger, P<.01 vs U-46619 alone).
Inhibition of NO release with L-NAME (10−4 mol/L) had no effect on U-46619–induced changes in Kf. These data are shown in Figure 2. Even a 100-fold increase in the dose of L-NAME (10−2 mol/L) did not significantly alter the effect of U-46619 on Kf (0.019±0.003 g·minute−1 ·millimeters of mercury−1·100 g of body weight−1). The addition of SNP (10−8 mol/L) to the perfusate reduced U-46619–induced changes in Kf by 50% (P<.01). A 100-fold decrease in the concentration of SNP (10−10 mol/L) had a similar effect on U-46619–induced changes in Kf (0.006±0.001 g·minute−1·millimeters of mercury−1·100 g body weight−1). In the absence of U-46619, the addition of SNP or L-NAME had no effect on the Kf of Krebs-Henseleit buffer–perfused lungs.
The effect of L-NAME and SNP on U-46619–induced vasoconstriction is shown in Figures 3 and 4. In contrast to its effect on Kf, the presence of L-NAME in the perfusate of the isolated, perfused lung notably enhanced the vasoconstrictive effects of U-46619. The change in PA induced by U-46619 in the presence of L-NAME was twice that induced by U-46619 alone (P<.01). The change in Rt of lungs exposed to L-NAME and U-46619 was about 60% greater than that of lungs treated with U-46619 alone (P=.06). The addition of the 10-mmol/L concentration of L-NAME to the isolated, perfused lung did not result in greater vasoconstriction than that induced by the 100-µmol/L concentration. The addition of SNP (10−8 and 10−10 mol/L) to the perfusate completely abolished the vasoconstrictive effects of U-46619 with or without L-NAME. The addition of L-NAME or SNP to the perfusate of the isolated, perfused lung in the absence of U-46619 had no effect on PA or Rt.
These experiments are consistent with the hypothesis that the lungs release NO as a protective, compensatory mechanism in response to TXA2. Evidence is provided by the observations that (1) cGMP is released by the lungs in response to TXA2 receptor activation; (2) inhibition of the constitutive release of NO by the lungs exacerbates the vasoconstrictive effects of U-46619; and (3) the provision of exogenous NO attenuates the vasoconstriction and increased capillary permeability that characterizes TXA2-mediated microvascular dysfunction.
Thromboxane A2 has been incriminated in the pathogenesis of pulmonary microvascular dysfunction in adult respiratory distress syndrome4 and in a plethora of animal models of acute lung injury.1- 3 The U-46619 binds and activates TXA2 receptor and is a useful tool for studying its effects on microvascular function.15 The principal effects of the activation of TXA2 receptor on the microvasculature include vasoconstriction that results in increased capillary hydrostatic pressure and enhanced permeability to fluid and solutes. Together, these phenomena contribute to the development of pulmonary edema during systemic inflammatory states.
Our study demonstrates that within 15 minutes of TXA2 receptor activation there is a 4-fold increase in pulmonary NO release. These findings are similar to those of Wilson et al12,16 using a similar experimental model. Many investigators have implicated increased vascular shear stress as an important signal for endothelial NO release.12,16- 18 Vascular shear stress is proportional to the flow rate and viscosity of the perfusate and inversely proportional to the diameter of the vessel. Hence, vasoconstrictors such as U-46619 should increase the shear forces in vessels perfused at a constant flow rate such as in our study. Wilson et al12 demonstrated that the addition of U-46619 to lungs perfused at a constant rate increased NO release; this effect was not observed with those perfused at a constant pressure. Other investigators have related NO release in isolated lung models to increasing perfusate viscosity16 and flow rates.19
Our study also suggests that the constitutive release of NO by the pulmonary vascular endothelium attenuates the vasoconstrictive effects of TXA2. Evidence is provided by the observations that L-NAME enhances and SNP prevents U-46619–induced pulmonary vasoconstriction. Similar results have been reported by other investigators using the isolated, perfused lung model in which U-46619–induced vasoconstriction was found to be augmented by the NO synthase inhibitor Nω-methyl-L-arginine and the soluble, guanylyl cyclase inhibitor 6-anilino-5,8-quinolinodione (LY 83583).12 In other in vivo and in vitro models of acute lung injury, NO administered by inhalation or intravascular NO donors attenuates the vasoconstrictive effects of oxidants,10,20 remote organ injury,21,22 and endotoxemia23; agents that inhibit NO release enhance the vasoconstrictive effects of these injuries.10,20,21,23 The therapeutic potential of these findings has been realized with the use of inhaled NO in the management of patients with adult respiratory distress syndrome and other disease states in which pulmonary hypertension is a important component.24,25
It is less clear whether endothelial-derived NO protects the lung from TXA2-mediated changes in microvascular permeability. This conclusion is based principally on the observation that inhibiting NO release with L-NAME had no effect on U-46619–induced changes in Kf; however, the NO donor SNP attenuated U-46619–induced changes in permeability. One would have anticipated that if endogenous NO release protects the pulmonary microvasculature from TXA2-mediated changes in permeability, inhibition of NO synthesis would exaggerate the changes in Kf associated with U-46619.
These results may have been related to the neutrophil-depleted nature of this experimental model. Investigators using similar buffer-perfused lung models have demonstrated that inhibition of NO synthase does not affect microvascular permeability in either normal or acutely injured lungs.10,11 In contrast, the provision of even small quantities of NO has been shown to protect the lung from TXA2-mediated microvascular dysfunction and dysfunction associated with oxidant exposure,10 pulmonary ischemia-reperfusion injury,11 and remote tissue reperfusion injury.21,22,26 Interestingly, in vivo models of acute lung injury show that inhibition of NO synthase with L-NAME notably increased the extravasation of plasma proteins into the lung.21,26 In each of these models, L-NAME–induced increases in pulmonary microvascular permeability have been associated with increases in neutrophil sequestration within the lung, a phenomenon prevented by NO donors. These data are consistent with the findings of Kurose et al,27 who attributed, at least in part, L-NAME–induced increases in intestinal microvascular permeability to neutrophil recruitment and to neutrophil-mediated tissue injury. In these and subsequent studies, inhibition of NO synthesis with L-NAME has been shown to up-regulate the expression of many endothelial adhesion glycoproteins, including P-selectin and intracellular adhesion molecule–1, suggesting an important functional relationship between endothelial-derived NO production and the expression of various endothelial adhesion molecules.27,28
There are several potential mechanisms by which exogenously administered NO may have attenuated TXA2-mediated changes in microvascular permeability. One of these mechanisms is a direct effect on the endothelial cytoskeleton along with stress fiber disassembly and expansion of intercellular junctions.29- 31 Nitric oxide has been postulated to maintain normal microvascular permeability by preserving endothelial cytoskeletal integrity and normal intercellular junctions,27,32 although the mechanisms by which this might occur are poorly defined.
Given the neutrophil-depleted nature of the isolated, perfused lung system used in our study, it would seem unlikely that the primary effector of TXA2-mediated changes in microvascular function is the neutrophil. Nevertheless, Siebert et al33 have suggested that neutrophils sequestered within the pulmonary microvasculature during harvesting of the lungs may contribute to the microvascular dysfunction in this experimental model. This may be particularly relevant given the previously described relationship between the constitutive release of NO and neutrophil-mediated tissue injury.21,26- 28
Last, the release of NO by the vascular endothelium may also serve to limit oxygen-free, radical-mediated endothelial injury. Nitric oxide inhibits neutrophil superoxide anion production by a direct effect on nicotinamide adenine dinucleotide phosphate oxidase.34 Furthermore, many investigators have presented evidence that NO released constitutively by the endothelium scavenges superoxide radical and prevents oxidant-mediated tissue injury.35,36 In addition, NO may also induce the synthesis and activity of other antioxidants such as heme oxygenase.37
Many laboratory studies and a handful of clinical studies have sparked tremendous enthusiasm for the development of therapeutic regimens that either augment NO delivery to the microvasculature or inhibit its exaggerated production. Dysfunction of NO formation by the vascular endothelium has been implicated in the pathogenesis of diseases as diverse as hypertension, hypercholesterolemia, diabetes mellitus, ischemia reperfusion injury, angina pectoris, and various forms of circulatory shock.38- 43 Several investigators have suggested that the administration of NO by inhalation may be associated with notable improvement in pulmonary function in patients with adult respiratory distress syndrome.24,25 Our study suggests that the beneficial effect of exogenous administration of NO may be due to the restoration of normal pulmonary microvascular permeability and reduction of pulmonary capillary hydrostatic pressure. Other studies have related the hemodynamic "collapse" associated with septic shock to the overproduction of NO. These investigators postulated that inhibition of this exaggerated NO release will prevent or attenuate the hypotension associated with septic shock.44- 46 The observations in our study are consistent with those of other investigators,47,48 suggesting that the pharmacologic inhibition of endothelially derived NO (eg, that which occurs following treatment with nonselective NO synthase inhibitors such as L-NAME or nitroglycerine-monomethyl-L-arginine) may in fact be detrimental. In patients with acute lung injury, the nonselective inhibition of NO release may actually worsen pulmonary hypertension, ventilation-perfusion mismatch, and oxygen delivery in these already critically ill patients.
This work is supported in part by a merit review grant from the Department of Veterans Affairs, Dallas, Tex (Dr Turnage) and a research grant from the American Lung Association of Texas, Austin (Dr Turnage).
Presented in part at the 18th Annual Meeting of the Surgical Infection Society, New York, NY, May 2, 1998.
Corresponding author: Richard H. Turnage, MD, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-0156 (e-mail: firstname.lastname@example.com).
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How to Relocate Happily When You're Single
This article originally ran on Aug. 17, 1999
New job? Congratulations. Relocating and single? Good luck. Your best wishes and worst fears may come true during your move. The good news is that you'll feel energized by discovering a new place, people and activities and beginning again as a new you.
A relocation provides an opportunity to rethink who you are and what you want in your life. It's a chance to dump old baggage and recreate yourself. No one who knows you is around, so you can change your hairstyle, lifestyle, behavior and even your nickname if you choose. The old script is gone. It's a great time for renewal, so make the most of it.
The bad news is you'll eat alone, not know how to find your way around, have no close friends nearby and dwell daily in the unfamiliar. At times, you'll feel uncertain and ungrounded. Moving is difficult at any age, but it becomes more challenging the older you get. You have more to leave -- friends, memories and comfortable routines. In your present locale, you know how to get everywhere and where to find everything. You fit in and belong. All that will change when the movers arrive.
It's a new beginning, but not always an easy one. Life can feel exciting and fulfilling -- and isolating and lonely. It takes moxie to lessen your difficulties and enhance your opportunities. Here are some steps to take before you move and after you arrive to make yourself more comfortable.
Before You Move
1. Have a plan. Before you relocate, spend time reflecting on who you are and what you want your life to be like in your new home. Do you want a large network of acquaintances, to join a bowling league, to meet fellow square dancers, affiliate with a specific religion or church or to be active in a civic association? What are your interests? Are you open to new interests? The more reflecting you can do before you move, the more prepared you'll be to hit the ground running when you arrive.
A Colorado professional had always lived inland before moving to the West Coast to pursue a Ph.D. He planned to take sailing lessons when he arrived. That way he'd not only take advantage of living near water, but he'd also learn a skill and make new friends.
When a real-estate broker moved from a small town to a city two hours away, she planned to try four new organizations -- a church group, Parents Without Partners, a yoga class and the Rotary Club.
"I knew at least one of them would be a fit," she says. "Many people join one, are discouraged and quit. I made myself a one-year commitment."
2. Subscribe to the Sunday paper and the community newspaper of your new city or town for a few months before you arrive. It's important to know what's happening locally if you want to participate in conversations. What are the big news stories? What are residents thinking and talking about?
Learn the names of local elected officials and gain insight about current issues, which organizations and companies are having the biggest impact and how the local high school, college and professional sports teams are doing. Clip items that appeal or interest you.
Learn the local sayings. For example, Seattle residents say, "The mountain is out." This means that it's a clear day and you can see Mt. Rainier. In New York City people order egg creams, a drink that has neither eggs nor cream. That's important local knowledge.
A human-resources professional who relocated to St. Louis always checked the papers for items like museum talks, gallery walks and lectures. "When people are involved in their leisure and pleasure oriented activities they are, in my opinion, much more open to meeting new people," she says.
3. Go to the Web. Information and assistance about your new location is as near as your keyboard. Don't know where to get started? Using your favorite search engine, simply type in the name of your destination city and you're on your way. You will probably find links to a variety of interesting destinations. Also check with the local Chamber of Commerce. It's their business to help you. Most likely, it can send a relocation package.
4. Contact any group you're affiliated with and ask for the name of a local contact in your new community. Do you belong to a church or temple? Fraternal organization? Alumni association? Professional organization? Call in advance and make a list of people to contact as soon as you're settled. Don't forget your activities and interests. Are you interested in historic preservation? Do you like to hike? Use these hobbies as starting points.
5. Send change of address cards to everyone on your holiday card list -- friends, colleagues, family, old roommates. Don"t just announce your new address and phone number. Ask for names, phone numbers and e-mail addresses of their friends and associates in your new location. It's always easier to call a stranger if a mutual friend referred you. Most people are happy to welcome friends of friends. When you arrive, phone each person and ask to go for a walk, meet for coffee or for directions to the best bakery in town.
After You Arrive
1. Say, "Yes." This is a new life adventure, an opportunity to start over again. Sure, you're an adult with definite preferences, but life is filled with new possibilities. Say "yes" to something you've never tried before. How about Rollerblading? Even if the idea seems ridiculous, can you at least become open to the idea of being interested? Will you try it once? How about trying racquetball, watercolor painting, a classical music course or swimming three times a week? It's easy to say no and stay comfortably in a rut. However, this is a new chapter in your life. It's time to say yes. Remember that you're having an adventure.
In his 50s and making a 2,000-mile move from Houston to Cincinnati, a college professor had a hard time meeting people outside of work. To make friends, he took several community college courses -- two on antiques, a couple on playing the dulcimer, several on yoga.
2. Instead of being alone, take the initiative. Don't keep score of who invited whom how many times. It's true that Miss Manners advises everyone to reciprocate invitations. But most local residents had a social life before you arrived. They may just forget to reciprocate. Be generous with forgiveness. Keep taking the initiative; don't wait for others to do it. Give people another chance to get to know you better. If you want them to make room for one more friend, you may have to extend the invitation. Your new acquaintance will likely enjoy meeting you for a movie, game of tennis or museum visit.
It's hard not to feel sorry for yourself, particularly at holidays. If you're going to be alone for Thanksgiving, Christmas or New Year's Eve, why struggle to just get through it when you can do something constructive and fun? Invite others to join you or consider having your own party. You aren't the only one in town without local family and friends.
By mid-December, a nonprofit arts consultant who had moved from Boston to Seattle expected to spend New Year's Eve alone with a TV dinner and a video. Instead, she invited three new acquaintances to the "First Annual Single Women's' Potluck New Year's Eve Party." She asked each woman to bring a friend who also would be alone. The group had a wonderful time and agreed it was one of the best New Year's they ever spent. And everyone met someone new.
At times, you may become tired of going places alone and decide to stay home instead. That's understandable. Few people look forward to entering a room full of strangers. Don't give up that easily. Invite someone to join you. If he or she can't come, go anyway. Make it easier by calling the organizers, saying that you're new in town and asking if a member would be willing to host you. Or call the organizers and volunteer to help. Perhaps you can greet people at the door as they arrive.
3. Volunteer. One of the best ways to learn about a community and make friends is to volunteer. What needs changing to make the world a better place? What can you contribute, donate, volunteer or nurture? Decide what interests you and how you'd like to make a difference in the community. You'll be meeting new people and doing something to help others.
Perhaps there's a nonprofit organization your employer supports. Most businesses contribute to favorite community efforts -- a Little League team, the United Way or arts organization. Perhaps you can become a sports team coach, United Way-fund drive coordinator or board member.
4. Get a schedule. With a wide-open calendar, life can seem overwhelming. What will you do to fill up your leisure hours? Working late and weekends isn't the answer. Create a schedule. Each week, fill it in with social, recreational and civic activities. Volunteering is a wonderful way to define your week. You'll be committed to doing something at a specific place and time. An exercise routine also helps. Planning to invite a new contact for coffee once a week will keep you busy. So will taking a course or attending lectures.
5. Meet your neighbors. If there's a neighborhood association in your area, join it and attend meetings. Find out what's going on in your immediate community and who's "in the know." Tell them you're new in town and would like to know about "X." This could be a hobby, the names of good restaurants, best ways to meet people, ways to get acclimated to the region, etc. Everyone enjoys giving advice. Where are the local hangouts? Is there a bookstore where people congregate? Where do natives go for breakfast or to watch Monday Night Football?
Make an effort to meet those who supply the basics -- your banker, dry cleaner, florist or grocery-store manager. Find a coffee or sandwich shop that's comfortable. When you need to be around people, go there with a book, newspaper or correspondence. You'll become a regular quickly.
6. Be on vacation. Make your new environment your playground. Get a guidebook and explore. If you're a member of an automobile association, order a city or state guidebook and map. The college professor who moved to Cincinnati just "got in the car and drove all over the place, visited malls and stores to get the lay of the land."
Also find out what's special and distinctive about your new community so you can show relatives and other visitors around when they come. One professional woman, who moved from the U.S. to Indonesia, calls this process "therapeutic recreation."
"You'll reduce stress and get to know the city well enough that you can be a great tour guide to visiting friends and family," she says.
7. Make yourself comfortable. Spend time and money making yourself physically and emotionally "at home" in your new surroundings. Instead of "making do," make your living space fit your style of living without spending too much money. Spruce up your bedroom or buy a reading light you've been wanting. Hang pictures and set out objects that are special to you. Your new home will reflect who you are if you surround yourself with familiar items.
8. Use your support system. Plan on having a large phone bill for the first six months to a year. When you're feeling lonely, nothing is working well and you miss "home," remember that many people love and support you. Call them and let them know how you're doing and the details of your adventure. New friends don't know you well enough to notice if you're depressed. They also may find it hard to be with someone who's unhappy. Use your old friends to share the ups and downs.
9. Give yourself a break. Starting over is hard work and takes time. Everything won't work well at the outset. Being in an unfamiliar environment and taking the initiative requires energy. Find ways to renew yourself. If this comes from walking in the woods, a long bath or playing racquetball, include time for these activities. It's easy to nourish yourself with food, alcohol or cigarettes. Don't. You'll feel better physically and emotionally if you maintain your normal exercise regimen and diet.
When All Else Fails
1. Walk your dog. Walking your own (or someone else's) dog is a perfect way for you both to make new friends. A corporate treasurer who moved from San Diego to Seattle says walking his dog, Rocky, twice a day helped him to socialize. "Here I was, a guy with a non-threatening dog," he says. "I became a magnet for women and Rocky had fun, too."
2. Get a traffic ticket. After three months in San Francisco, a product manager who had moved from Boston was surprised when she was pulled over by the police. She received a ticket and an invitation to attend traffic court. She went and met the man who became her husband.
The best advice in the world won't change the enormous emotional and physical upheaval relocating can present. But life at the end of a long-distance move is good if not better. It takes time and patience to make lasting friendships and feel comfortable. Remember, friends are acquaintances who have stood the tests of time and life. And that's something you have plenty of -- time and life. Use them well and one day your new city will be "home."
Ms. Wallach is a career and organizational consultant and writer in Seattle.


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The House Ethics Committee is expanding its investigation of Rep. Charlie Rangel, D-N.Y.
This comes after his late financial disclosure of hundreds of thousands of dollars in previously unreported assets.
Rangel is the Chairman of the House Tax Writing Committee -- but failed to pay all of his taxes.
Republicans have failed three times in their attempts to have him removed from that committee.
"I think there's a great deal of challenge that the House Ethics Committee has in that they've not acted," Rep. Peter Roskam, R-Ill., said.
"It's been over 12 months and it's reached the point we've gotta think, are they really serious about engaging this, or are they just in a stall pattern? And I think ultimately it hurts the institution and I think it hurts the Speaker," Roskam added.
House Speaker Nancy Pelosi, D-Calif., has said she will not remove Rangel as committee chair while he's being investigated.
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By JAMES BENSON
Well, that didn't take long.
Within a few short months after his second inaugural, President Obama is witnessing the dissolution of support he thought he had from the American people. While he mistakenly assumed his re-election was an endorsement of his prior policies, it was more like the electorate giving him a second chance to get it right.
Polls consistently say Americans need to see improvement in our financial situation, such as controlling spending and reducing the national debt. Obama arrogantly makes it clear that is not going to happen. Even after raising taxes on "the rich" he immediately demanded more, to satisfy his spending urges.
When sequestration (his suggestion) took effect, he played his typical scare tactics, then applied pain to the populace, claiming there were no alternatives to cutting expenses.
The American people, rather than caving to demagoguery, now recognized that the Obama administration is simply incapable of financial management.
While the administration boasts significant progress in the pitiful unemployment situation, critics note fewer workers employed now than when Obama took office. And how long will he block the XL Pipeline?
The Benghazi tragedy and cover-up: Combined with a worsened economy, this will be the Obama legacy.
[The writer is a member of the Staten Island Tea Party.]


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A brand new gallery on the scene, and another - four months old - that's already changing shows more often than originally planned: Are our artists getting restless?
The new gallery is "La Chera," 1913 Bell St. inside Spike's Realty. Founding artists Cheryl Squyers and Laura Moser are featured, as is Glenn Lyles of Plainview. Works by Ben Konis, the late Robert Wood and New Mexico artist Iva Morris give the show additional depth.
Standout paintings are Konis' "Dinner Time," Lyles' "Potter County Temperance Society," Moser's "Summer Pickets" and Squyers' "Chillin'." Konis' pastel is gracefully radiant; Moser's acrylic is precisely mysterious; and "Chillin' " puts pastel at the service of a schnauzer's whiskers.
Squyers also wields watercolor with brio in "Pansy Puddle." Lyles' canvas is a variation of a favorite theme of his, cattle heads at a tank; there's a unique, abstract boldness to his handling of bovine forms and colorful water.
The place going beyond initial exhibit expectations is IC Gallery at 1501 S. Washington St., where "Pushpin Photography" features matted but unframed works by Louise Daniel, Jamie Harmon, Scott Hyde, Jim Jordan, Chuck Kitsman, Phillip Periman and Ken Pirtle.
In the works of three, one could say that nature should get the credit for beauty - but each photographer excels in translating this in his or her own unique way.
For Jordan, perfect poise and stillness are prime expressive qualities. Kitsman's images imply movement and flow - of light, space, wind, water.
Daniel's special talent is for creating visual substance from vast reaches of empty space. In varied ways and to varying degrees, loveliness echoes in their images.
Harmon chooses to fill his wall space with a single large black and white image that's a composite of many smaller photos. It's an experiment, a successful photo-chemical precipitation of exuberant youthful physicality.
Pirtle's images are diverse in subject, ranging from plays with the appeal of female form, straight images and some purely funky freak-outs. Attitude is his game, in which he enlists computer technology for incongruous options.
Hyde has number of stereoptical visual cocktails. These are deliberately cheap prints, fascinating remnants from New York whose street life he celebrated with objective intimacy via an insistently clicking shutter and a mind excited by printing techniques.
Periman's images are all from Chartres Cathedral in France and convey the spiritual yearning of sculpted saints in sensitive adjustments of light and shadow. Adroitly chosen angles emphasize the figures' soberly expressive movements.
Armstrong County Museum in Claude is showing "Spirit Figures from the Renegade Land: Acrylics by John Romero."
The adjective "adumbral" (shadowy, unclear) seems particular apt for his looming, deliberately clumsy forms and their curtailment of descriptive detail. Many see his work as personally eccentric and difficult to appreciate. But he has stuck to his personal style of visionary beasts and natives.
Several recent paintings - especially "Illuminations" and "Circle Maker" - have less ominous overtones than earlier works, and express something in the way of new venturing. Some small, mixed-media abstractions are particularly eye- and spirit-catching.
Hunter Ingalls received a Golden Nail Award for support of the arts with Lost Circus gallery and performance center in 1989. His many years of experience as a teacher include faculty positions at the University of Texas at Austin and Columbia University, where he earned a Ph.D. in art history in 1970. He may be reached in care of the Globe-News or via e-mail at firstname.lastname@example.com.
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"Roll up! Roll up for the Magical Mystery Tour! Step right this way!"
It's increasingly difficult to find common ground in America these days.
They've reached the 50-game mark with barely a pulse. Time now for one of the rituals of summer. Time to write off the Cubs for another year.
Charlotte Brown finished fourth at the Texas high school Class 3A track and field championships. But she received a louder ovation than any of the other eight pole vault finalists.
Thursday marks the 30th anniversary of Major League Baseball's longest game. Friday, too. That's right. The game took two days to complete. A long, strange trip.
Scott Carroll pitched for the Chicago White Sox on Sunday.
"When I got to the 10 tee box, I still believed I could win the tournament, no doubt about it. I still thought that Bubba…"
On July 27, 1993, Jordan Spieth was born.
"Is that Bubba?" one patron asks another.
He walks up the 17th fairway at Augusta National uncomfortably upright, his hands clutched to both ends of a 7-iron that stretches toward the sky behind his head. He rocks the club from one hip to the other, bending his back side-to-side as he grimaces.
The Masters tournament is right around the corner, and when Jim Nantz of CBS welcomes us to Augusta National with his signature "Hello, friends" opening remark, he'll undoubtedly refer to the Masters as "a tradition unlike any other."
Tune the piano.
You've won.
March Madness, indeed.
It's tournament time!
Page 4 of 19
An old coaching adage holds that teams see the most improvement early in the season, their identities steeled by a few games' experience.
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A process can be identified by a series of unique, but consistent, characteristics. There are six characteristics of a process that are mandatory for effective quality management.
While ISO:9001:2008 utilizes checklists for audits, TS16949:2009 requires process-based audits. This is a significant change and internal auditors need to be trained and developed using the process-based audit approach.
Key Differences between ISO 9001 & TS 16949 Audit


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Erie police seek information in weekend assault
Erie police are looking for information in a weekend assault on the city's east side.
Police said a 31-year-old man is in critical condition at UPMC Hamot after he was assaulted in the 500 block of East 21st Street on Friday at about 10:30 p.m. The man initially was believed to have been injured in a fall, but it is now thought that he was assaulted, possibly by four to five young males, police said this morning.
Anyone with information is asked to call Erie police Detective Sgt. Barry Snyder at 870-1506.


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Trend analysis using interactive performance reports is a key feature of the InfoSphere Optim Performance Manager for DB2 for LUW web console. The reports help organizations to identify bottlenecks in database performance, and they can be analyzed to help prevent performance issues in the future.
Learn to use the CLU to generate performance reports in offline batch mode without using the Optim Performance Manager web console. By bypassing the web console, you can generate reports remotely and schedule report generation at periodic intervals using a scheduler (for example, Windows Task Scheduler or UNIX Cron). Download the sample scripts.
In Optim Performance Manager 5.3, you can use the CLU to generate the types of reports shown below.
Table 1. Reports generated by the command-line utility
|Snapshot Mode
|In-Memory Mode
|Database Configuration (DBCFG)
|Database Configuration (DBCFG)
|Database Manager Configuration (DBMCFG)
|Database Manager Configuration (DBMCFG)
|Performance Overview
|Performance Overview
|SQL Baseline Comparison
|Storage Group (DB2 10 and above)
|Table Usage
|Table Usage
|Diskspace Consumption
|Diskspace Consumption
|Top SQL Package
|Top Dynamic SQL
|Top SQL
|Workload Manager Overview
|Workload Manager Overview
|Workload Manager Service Subclass
|Workload Manager Service Subclass
|Workload Manager Service Superclass
|Workload Manager Service Superclass
|Workload Manager WorkAction Set
|Workload Manager WorkAction Set
|Workload Manager Workload
|Workload Manager Workload
You cannot use the CLU for any of the detailed reports that can be generated using the Optim Performance Manager web console or the Cross-Database Overview report. To automate the generation of a Cross-Database Overview report, schedule the report to run at specified intervals in the web console.
To follow along with the examples, you should have installed and configured InfoSphere Optim Performance Manager for DB2 for LUW and collected some performance data. (The IBM Information Center has details about installing and configuring InfoSphere Optim Performance Manager.) You will also need:
- JRE 1.6 or higher
- 250 MB of hard-disk space for expanding the CLU
- Additional hard-disk space to store report files generated by the CLU
- Connectivity between the system where Optim Performance Manager is installed and the system from which the CLU is being executed
- Connectivity between the system where the monitored database is installed and the system from which the CLU is being executed
To create reports, you must select the following monitoring profiles in the database monitoring configuration: Basic, Locking, SQL Statements and Connections, I/O and Disk Space, and Workload Manager.
Downloading the CLU from the web console
After a database has been configured for monitoring, performance data is collected at specified intervals and stored in the repository database. Reports can then be created for any time period during which monitoring data is available in the repository database.
Before you can use the CLU to generate reports offline, you must use the web console to specify initial report settings and download the necessary files.
Complete the following steps to download the CLU and other required files:
- Click the Open menu and select Predefined
Figure 1. Open Predefined Reports
- Select the report type and fill in the required
fields. Click Save Report Definition to start
downloading the files required to run the CLU.
Figure 2. Download CLU
Select the Report format and the Target operating system (the platform on which you will execute the CLU).
If you've never used the CLU, you must select Download script file and library files. This option downloads the library files required to execute the script file that generates the report. In the future, if you want to use the CLU again, you can choose to download the script file only.
Figure 3. Download required files
- After the download completes, expand the .zip file into a new
directory — c:\clu_directory\, for example. The resulting directory
structure should look like the image below.
Figure 4. CLU directory structure
Important directories
A couple of the folders in the CLU directory structure are especially important, as follows.
- Generated Reports
- The Generated Reports folder is the default output location for
reports generated when you run the CLU script. You can change the output directory for generated reports to
any directory by changing the
OPMREPORTOUTPUTPATHparameter in the Command Line Utility script file.
- Logs
- The Logs folder contains the log file, which contains entries for any
errors that occur during the creation of the report file and whether
the job was successful. You can change the output directory for log
files to any directory by changing the
LOGFILEPATHparameter in the Command Line Utility script file.
Generating a report with the CLU
Before you use the script, or batch file, to generate the report, review the file for the parameters that affect report generation, as outlined in Table 2.
Table 2. Optim Performance Manager repository connection parameters
|Parameter name
|The name of the file. This must be identical to the script file name. If the file name for the script is changed, this parameter must also be changed to the same value.
|The host name or IP address of the repository database. This value can sometimes be set to 127.0.0.1, in which case you must change it before you can generate a report. This can happen because of the way values were provided during InfoSphere Optim Performance Manager setup and configuration. If necessary, change the value to the actual IP address on the Configuration Repository window, as shown in Figure 5.
|The decrypted password to log on to the repository database. To use this password, overwrite the clear-text password and uncomment this parameter.
|The format in which the report should be generated. Supported formats are PDF, PPT, and XLS.
|The end time of the report. Together with the
REPORTDURATION parameter, it defines the time
period in the monitored database time zone for which the
report is generated.
Figure 5. Configuration Repository
After you modify the parameters as needed, generate a report by executing the script (batch file) as follows:
- Ensure that the .bat/.sh script file is in the same directory where the CLU library files were expanded, as shown in Figure 4.
- On UNIX (including AIX and Linux) systems, run
chmod -R 755 clu_directoryto set the required file permissions on all of the files and folders in the expanded directory structure (shown in Figure 4).
- Execute the .bat/.sh file to generate the report. The generated reports are created by default in the .\Generated Reports folder, as explained in Important directories.
Scheduling CLU report creation
To use the Windows Task Scheduler or UNIX Cron to schedule report generation or to automatically send a generated report as an email attachment, you must make a few changes to the script file. The following examples show the necessary changes in a sample script that generates a Performance Overview Report on Windows:
- Add a line to the top of the script file that changes the working
directory to the directory where you expanded the library files, as
shown in Figure 4. In this example, the directory
is named clu_directory, as in Listing 1.
Listing 1. Change working directory to the CLU directory
cd clu_directory
- Change the
REPORTENDTIMEso that for each execution, the required time frame would get selected. For example (on Windows), the
REPORTENDTIMEparameter could be changed so that the current execution time is taken as the
REPORTENDTIME, as shown in Listing 2.
Listing 2. Change for
SET repEndDtStamp9=%date:~-4%-%date:~4,2%-%date:~7,2% 0%time:~1,1%:%time:~3,2% SET repEndDtStamp24=%date:~-4%-%date:~4,2%-%date:~7,2% %time:~0,2%:%time:~3,2% if "%HOUR:~0,1%" == " " (SET REPORTENDTIME=%repEndDtStamp9%) else (SET REPORTENDTIME=%repEndDtStamp24%)
- The CLU typically waits for user input after creating
the report. When you schedule a report to run, however, you do not
want to require any user input or intervention. Thus, to schedule a
report, you must add the code in Listing 3 before the last
java -cpstatement in the script.
Listing 3. Letters in bold to be added
For AIX/Linux yes ''| java –cp ".":"config.properties":"$BIRTHOME/lib/*"………………. For Windows echo .| java –cp ".":"config.properties":"$BIRTHOME/lib/*"……………….
- You can email the generated report to a set of recipients by using
Send-MailMessage, as shown in Listing 4.
Listing 4. Send mail
For AIX/Linux mailx or uuencode For Windows (7 and greater) powershell Send-MailMessage -to %TOMailList% -from %FromMailID% -subject %Subject% -Attachments %REPORT% -SmtpServer %SMTPSERVER%
This article provided step-by-step instructions for downloading, deploying, and using the Optim Performance Manager CLU in offline mode. The CLU significantly extends reporting functions so you can generate and email reports in your own environment without any dependency on the Optim Performance Manager Console server being available.
|Sample Performance Overview Script for hourly run1
|Sample TopSQL Report Script for hourly run2
- This is a Windows .bat file.
- This is a UNIX/AIX/Linux .sh file.
- Read about Reporting with InfoSphere Optim Performance Manager in the IBM Information Center.
- The IBM Redbooks® publication titled "Performance Management: Using IBM InfoSphere Optim Performance Manager and Query Workload Tuner" describes the architecture and components of IBM InfoSphere Optim Performance Manager Extended Edition.
- Learn more about InfoSphere Optim Performance Manager for DB2 for Linux, UNIX, and Windows features.
- The IBM InfoSphere Optim Performance Manager 5.2 and 5.3 Information Center provides all the official documentation.
- Visit the developerWorks Information Management zone to find more resources for DB2 developers and administrators.
- Stay current with developerWorks technical events and webcasts focused on a variety of IBM products and IT industry topics.
- Follow developerWorks on Twitter.
- Watch developerWorks on-demand demos ranging from product installation and setup demos for beginners, to advanced functionality for experienced developers.
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text:
"Where Fillmore County News Comes First"
Online Edition
Friday, September 30th, 2016
Volume ∞ Issue ∞
- 9:09:57, Sep 30th 2016 - email@example.com - Ella and family, Sorry for your loss of Roger! You ... [Read More]
- 5:26:29, Sep 27th 2016 - Thomas E. H. - @ Kim Wentworth, ^the last post was from me. I just wanted to be c ... [Read More]
- 3:44:00, Sep 27th 2016 - Kim Wentworth - @Thomas E. H.- the planet's temp changes, goes thru cycles, a tweak u ... [Read More]
- 1:58:02, Sep 27th 2016 - @ Kim Wentworth - That previous post was directed to Mr. Schwartzentruber. If you ha ... [Read More]
- 10:10:34, Sep 27th 2016 - Kim Wentworth - @ Thomas E. H.- I will have to rely on you to tell me if you are jok ... [Read More]
- 9:15:13, Sep 26th 2016 - Patriot - Hello Hum. I disagree with your view on running K9 officers by vehicles in ... [Read More]
- 2:44:07, Sep 26th 2016 - Thomas E. H. - I would like to thank Mr. Schwartzentruber for illuminating Agenda 21. ... [Read More]
- 2:06:32, Sep 26th 2016 - Aaron Bishop - @ Kim Wentworth, Thank you for your comment. I did indeed mull that ... [Read More]
- 1:26:51, Sep 26th 2016 - Kim Wentworth - From the top: while neither side is perfect in the area of "facts" fo ... [Read More]
- 1:08:55, Sep 26th 2016 - Kim Wentworth - I think in the beginning you should have used the words "democrat" an ... [Read More]
Fillmore Central seeks to improve math scores
Thu, Dec 23rd, 2010
Posted in Education
Posted in Education
Fillmore Central Superintendent Myrna Luehmann gave the school board a presentation giving them more information about the Flexible Learning Year program.
Several schools in southwest Minnesota have combined to make a consortium, and applied to have school start two weeks earlier. There are now many districts in southeast Minnesota that are interested in doing the same thing. There are many reasons for doing this, and Luehmann explained some of them.
If Fillmore Central applies to be a part of this consortium, they will have to do so by February 15. Luehmann explained it is a three-year term they would be signing up for, and would start in 2011. In order to apply for the consortium, the school must hold three public meetings.
With the new schedule, the first semester would end before winter break, and the year would end approximately two weeks earlier. The schools that combine would have shared professional development days, which could save the districts money. Each school must pay into a pool $10 per student for each of the three years, and this money would be used for those professional developments.
Luehmann said they cannot reduce the number of student contact days. This schedule would be aligned with local colleges, as well as the other districts.
Along with cost efficiency or the trainings, the schools that collaborate could use certain technologies together. Luehmann explained that kids learn differently today than many years ago; they need a higher level of critical thinking. Schools today are working on getting kids ready for college and helping them through college, in what Luehmann referred to as "K-16" instead of K-12.
The board agreed they are interested in pursuing this. Board member Deb Ristau wanted to make sure all of the staff members are on board with the idea. Principal Heath Olstad said he will be meeting with staff as soon as winter break is over. They will then set up the three meetings that need to be held. They have no obligation until they make a commitment in February.
High School Math Study
During his Principal's Report, Heath Olstad informed the board of a pilot program that will be taking place for juniors. Olstad said the program would be to help the students in eleventh grade be more successful with their standardized math tests in the spring.
"We need to improve the overall math scores," said Olstad. "That's the bottom line."
Olstad explained that during third hour the kids who are not in band or choir have a 45-minute study hall. This program would set aside a half-hour chunk of time to be spent working on math skills. The two math teachers, Becky Mueller and Jane Montgomery, would be working with the kids, who would be split into four groups. Two days a week, the students would be working using the Study Island computer program. They would be given assignments to complete at home or the other days.
The two math teachers would be working a half-overload, and they have agreed to this. Olstad estimated the cost to be around $1,000 per teacher, and the board approved.
Olstad said they could consider giving the students a half-credit at some point, but right now they are going to try it out and see if it helps improve scores. Juniors who do not do well can continue this their senior year if needed.
The board approved hiring Sue Snell as a long-term sub for Janette Burns's maternity leave. Lisa Wilhelm was also hired to tutor a home-bound student for a short time.
The resignation of Deb Schott, part-time custodian, was approved. The board also approved the hire of Kevin Hendrickson to replace Schott.
The board also approved the resignation of Superintendent Myrna Luehmann, who will be retiring as of June 30, 2011. Chair person Ross Kiehne thanked Luehmann for her years of service to the district.
Kiehne recognized Sue Ostrom for her five years on the school board and presented her with a plaque. A plaque was also given to Jill Zmyewski, the FACS (Family and Consumer Sciences) teacher at the high school for being with the district for 16 and a half years. Luehmann also mentioned that Zmyewski is the one who makes the blankets for new babies born in the district that read, "Future Falcon."
Zmyewski thanked the board and administration for the opportunity to teach at this school, saying she loved every minute of it. "We are blessed to have such a wonderful staff and administration," she said. She also thanked them for supporting her program, which she thinks is very important for the students.
The Superintendent Search Committee met recently to discuss the current configuration and how they want things to be next year with a new superintendent. Board member Sue Sikkink said they are pleased with the way things are working now and would like to keep it that way. They will be looking for a part-time superintendent to start on July 1.
Chair person Ross Kiehne said he met with other board members from area districts, and none of them showed any interest in sharing superintendents. The ones who were there were happy with the way things are for now.
The committee will move forward with its search and have something ready by the next meeting to present to the board.
Other Business
The levy was approved at a 3.24 percent increase over last year, and was set for $1,536,117.13.
There were no community members present for the Truth in Taxation hearing.
The board approved hiring a new collection agency for Community Ed. in order to have better results getting money that is due.
The board also approved getting bids for the district insurance plan.
An open enrollment request was approved for a student in eighth grade who lives in Canton.
The board accepted the low bid from Smith Schafer for the district audit for the next two years.
The January school board meeting will also be the organizational meeting. It will be on January 25 at 8 p.m. in the high school media center.


text:
RELEASE: Pelosi address, Iraq war opposition to highlight 2007 National Student Conference
RELEASE: Pelosi address, Iraq war opposition to highlight 2007 National Student Conference
Contact: Madeline Meth
Phone: 202.741.6277
Email: firstname.lastname@example.com
Washington, D.C. – Speaker of the House Nancy Pelosi will deliver the keynote address to 1000 college and university students at Campus Progress's third annual National Student Conference, to be held Tuesday, June 26, 2007, at the Hyatt Regency on Capitol Hill in Washington, D.C. Several events at the conference will address the Iraq war, reflecting growing student opposition to the Bush Administration's conduct of the war. In addition to Speaker Pelosi, students at the conference will hear from Wisconsin Senator Russ Feingold, a leading opponent of the war, from Minnesota Representative Keith Ellison, from journalists Seymour Hersh and Asra Nomani, and from a closing panel of young Iraq war veterans.
Campus Progress is the youth organizing division of the Center for American Progress. The annual National Student Conference includes major speeches, panel discussions, and trainings on skills including working with media, organizing online, and building successful issue campaigns. Other speakers this year include former Senate Majority Leader Tom Daschle; public interest advocates Wade Henderson, Van Jones, Maria Teresa Petersen, John Prendergast, Jon Soltz, and Ralph Nader; blogger Jessica Valenti; and hip-hop artist M1 of Dead Prez. (Previous conference keynote speakers were Bill Clinton and Barack Obama.) Students from all 50 states and over 250 schools are registered to attend the conference.
Connecting with the focus on the Iraq war, the theme of this year's conference is "Our Time is Now." With young voters turning out in record numbers in 2004 and 2006, and with young advocates creating new vehicles for change every day, today's young people have the power and the voice to move America in a more positive, progressive direction right now. "Our generation doesn't have to wait to bring positive change on the issues, from war in Iraq to genocide in Sudan, from poverty in America to college affordability to global warming," said Madhu Singh, conference coordinator for Campus Progress. "If we organize effectively now, we can make a real difference."
The June 26 National Student Conference is bookended by two training days: a June 25 journalism conference, sponsored by Campus Progress and The Nation magazine, with speakers including Helen Thomas, Barbara Ehrenreich, Eric Schlosser, and Katrina vanden Heuvel; and a June 27 grassroots training, sponsored by Campus Progress, Wellstone Action, and the student PIRGs. In addition, Campus Progress and the United States Students Association have organized a June 25 student lobby day on the Iraq War.
To learn more about the conference, visit http://www.campusprogress.org/2007conference.
To learn more about Campus Progress, visit http://www.campusprogress.org.
Campus Progress, part of the Center for American Progress, works to help young people — advocates, activists, journalists, and artists — make their voices heard on issues that matter. Through an on-line magazine and student publications, public events, and grassroots issue campaigns, Campus Progress acts to empower new progressive leaders as they develop fresh ideas and communicate in new ways. The Center for American Progress is a nonpartisan progressive think tank dedicated to improving the lives of Americans through ideas and action.
To speak with our experts on this topic, please contact:
Print: Liz Bartolomeo (poverty, health care)
202.481.8151 or email@example.com
Print: Tom Caiazza (foreign policy, energy and environment, LGBT issues, gun-violence prevention)
202.481.7141 or firstname.lastname@example.com
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202.478.6331 or email@example.com
Print: Tanya Arditi (immigration, Progress 2050, race issues, demographics, criminal justice, Legal Progress)
202.741.6258 or email@example.com
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202.478.5328 or email@example.com
Print: Beatriz Lopez (Center for American Progress Action Fund)
202.741.6255 or firstname.lastname@example.com
Spanish-language and ethnic media: Rafael Medina
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TV: Rachel Rosen
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Radio: Sally Tucker
202.481.8103 or firstname.lastname@example.com


text:
At Unveiling of Ai Weiwei Sculptures, Artist Remains a World Away
As Chinese artist-activist Ai Weiwei's monumental bronze sculptures became the first public art exhibition at Grand Army Plaza, one of the gateways to Central Park, the artist himself remains detained in his homeland–a scenario Mayor Michael Bloomberg described as "bittersweet" in an address Wednesday.
One of China's most famous figures, Ai had been scheduled to attend the opening of "Circle of Animals/Zodiac Heads," but he has been in custody and under investigation for "suspected economic crimes"–and out of contact since he was led away by government officials at a Beijing airport on April 3.
As he unveiled the artist's 800-pound bronzes, the mayor criticized what he described as China's disregard for freedom of expression.
"Artists risk everything to create. They risk failure. They risk rejection. They risk public criticism. But artists like Ai Weiwei, who come from places that do not value and protect free speech, risk even more than that," Bloomberg said. "His willingness to take those risks, and face the consequences, speaks not only to his courage, but also to the indomitable desire for freedom that is inside every human being."
China's Foreign Ministry has said Ai's case has "nothing to do with human rights or freedom of expression."
Though he has created works around the world, including the Bird's Nest stadium for the 2008 Beijing Olympics and a recent exhibition in the Turbine Hall at London's Tate Modern Museum, Ai's New York City ties run far beyond the installation of his dozen sculptures around the Pulitzer Fountain at Fifth Avenue and 59th Street.
The artist studied at Parsons The New School for Design in the 1980s and lived in New York for more than a decade. Museum directors, including those from New York institutions such as the Solomon R. Guggenheim Museum, the Museum of Modern Art and the Brooklyn Museum, have signed a petition calling for his release.
"Beauty and inspiration are irrepressible; they are alive in every human heart – in every nation – and wherever an artist creates Ai Weiwei is there," Bloomberg said. "And today Ai Weiwei is here. Because even though he could not be here physically, he continues to speak to us, to delight us, and to challenge us through his art."


text:
Two Republicans will try to end Democrats' 16-year domination of the Mercer County freeholder board when they face off against a pair of incumbents in the November election.
County residents voted out the last Republican board member in 1997, but Ron Cefalone and Paul Hummel say they believe the county is ready for a change.
"When you do have a one-party rule it's dangerous," said Hummel, a 33-year-old East Windsor resident. "You've got to get an idea from both sides of the aisle."
The Republican candidates argue the freeholders have been reluctant to oppose the agenda of the administration, run by Democratic County Executive Brian Hughes.
"When you have seven members from one party, they're not going to say no to a lot of things," said Cefalone, a 42-year-old Hopewell resident and small business owner who has worked for county government in the past.
The incumbent Democrats up for reelection, Anthony Carabelli of Trenton and Andrew Koontz of Princeton, said the board has helped the county move forward in recent years while simultaneously working to keep the budget from getting out of control.
"This board has proven that we look very carefully at the administration's budget," Koontz said. "We bring in the department heads and the administration and ask them to justify everything."
Koontz, a 45-year-old teacher at Hightstown High School who is seeking his second term as a freeholder, said the board has provided strong oversight of the county administration in recent years and he will continue to push for that approach.
Hummel said county government needs greater transparency, which he would push for through televised meetings and a more user-friendly website. Freeholders are supposed to be working for the public, and the public should have access, he said.
"A lot of people don't even know what a freeholder is," Hummel said.
Cefalone and Hummel said they could save the county money by scrutinizing the budget and forcing the administration to do a better job negotiating contracts, two areas where they feel the current freeholder board has failed.
Another path to savings that Cefalone said he will push for if elected is consolidation. Princeton's recent merger is a prime example of the financial benefits of consolidation, he said, and other towns can follow. Even if smaller municipalities do not want to give up their autonomy, they can at least increase their use of shared services, which the county should encourage, Cefalone said.
Carabelli, a 78-year-old retired state employee who is wrapping up his 11th term on the board, also endorsed a continued push for shared services, saying that a steady increase in the practice will help county and local governments control costs in the long run.
Koontz agreed that shared services can bring significant savings, but said it can be difficult to develop policies for agencies and departments that work for multiple governments. Koontz said he saw the benefits and issues of shared services during his time as a Princeton Borough councilman, as the borough had many such agreements with Princeton Township prior to the merger.
While they share some similar ideas with their Republican challengers, Carabelli and Koontz disputed the notion that because the board members are all of one party, they cannot be good budget managers.
"Every cent has to be accounted for," Carabelli said. "If something comes up we can try it and evaluate it."
Social services are important, but programs funded by the county have to be effective, Carabelli said. When new services are proposed that have the potential to be beneficial to residents, he is open to trying them, but at the end of the year he wants to see the results, he said.
The Republican candidates said that Carabelli has served too long and that they will bring fresh ideas, but the most senior freeholder said he has developed relationships and gained experience that make him an expert at identifying waste and communicating with the county administration during budget negotiations.
Contact Brendan McGrath at (609) 989-5731 or at email@example.com.
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Home » PSY - GANGNAM STYLE » Download Oppan Gangnam style MP3, 3GP
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About TATYA :
My Name is Nilkanth Shirodkar and I have done MTech in Computer Science and currently working as a Software Engineer. My hobbies are gaining knowledge, reading, writing, playing Football, surfing net, listening to ♥ music ♥.
I am also a GEEK, technology enthusiast, software junkie and hardware addict .I just love – working with computers , surfing the internet and learning hacking.