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Systems biology pioneer Gene Network Sciences (GNS) will use its cancer expertise and computational modeling expertise to help choose optimal therapies for cancer patients at the Mary Crowley Medical Research Center (MCMRC) in Dallas. This is the first time biosimulation will be used to test treatments for actual cancer patients based on their individual gene expression data, says GNS.
Click here for a freeBio-IT World briefingon Systems Biology(registration required).
The deal is an important milestone for systems biology in general and modeling in particular. As part of the agreement, GNS will be compensated on a per-patient basis, representing another advance for systems biology providers, who have struggled to develop profitable business strategies. An Israeli company, Optimata, also uses biosimulation to choose optimal therapies, but it is less focused on incorporating patient gene expression data (see Optimizing Optimata, November 2005 Bio-IT World).
"We are very pleased to enter into this strategic relationship with Gene Network Sciences," said David Shanahan, president of the Mary Crowley Medical Research Center, in a press release. "This technological innovation will allow us a new means of developing safer and more-effective cancer treatments for our patients." GNS models will be used on a range of cancers. MCMRC treats many types of cancers, including breast, colon, lung and prostate.
MCMRC will use GNS computer models to help improve clinical trial success rates and advance patient care. GNS' biosimulation platform allows for the testing of efficacy and toxicity of compounds before they are introduced into a patient—something that previously was not possible. Recently, the dramatic growth of biological knowledge has combined with affordable high-performance computing to make biosimulation more attractive. The GNS computer lab occupies 150 sq. ft. of office space and is equipped with a 32-CPU supercomputing cluster (32 AMD Athlon MP 2000 CPUs) with a total of 16 GB of RAM and over 1 Terabyte of disk storage and 5 single- and dual-processor Windows 2000 and Linux servers. In addition, there is a 48-CPU cluster (48 Mac G5 Power PC CPU's) with a total of 24GB of RAM and 4.4TB of disk storage
"By using clinical data to predict who will benefit most from therapy, our models arm the researchers at Mary Crowley Medical Research Center with the power to improve clinical trial success rates and expand treatment options," said Colin Hill, CEO of GNS.
The MCMRC's primary mission is to explore investigational vaccine, gene, and cellular therapies with the goal of expanding treatment options for all cancer patients. By first filtering out drug candidates based on their efficacy in computer models fed with patient data, MCMRC specialists will be able to more accurately pinpoint drugs that will have an optimal effect on the patient.
Recognized as a national leader in cancer research with a particular focus on targeted therapies, MCMRC has performed hundreds of Phase I and Phase II clinical trial protocols, treated more than 3,000 patients, explored more than 100 new agents, and accomplished more than 140 FDA-approved clinical trials. The organization was established in 1992.
Gene Network Sciences is an early mover in the systems biology space and has developed a model of a "virtual" colon cancer cell. First focused on developing predictive mechanistic models, GNS has recently begun emphasizing bottom-up inference approaches that analyze large data sets to develop models. With this partnership, MCMRC gains the unique advantage of being able to use GNS computer simulations to test which therapies will have the best clinical outcomes for patients.
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Transitioning into Adulthood with Autism: Taylor's Story
"I did a ton of research as his mom to make sure that I understood the diagnosis and was advocating for him appropriately." – Kelly E., mom of a young adult with autism
In recognition of autism awareness month, we wanted to share some of our staff's personal experiences with their children's lives with autism. In this post, Kelly shares her son Taylor's transition into adulthood and how his autism affects it.
For the first five years of his life, Taylor had developed typically. He talked earlier than most, he was social and generally a happy baby.
"The only thing we noticed was that when we'd put Taylor down on a blanket, he wouldn't leave it, even after he learned how to crawl," reminisces Kelly, Taylor's mom. "I just thought it was brilliant but looking back, it was probably all related."
The First Indication
The first indication of an autism diagnosis didn't happen until Kindergarten when a teacher indicated that it might be a possibility. The teacher had shared that Taylor couldn't stand the sound of the fluorescent lights in the room. Kelly remembers, "I remember the teacher stating that they had to keep the lights off if he was in the room and how that was a problem."
This event, coupled with a few others, led to Taylor's diagnosis and Kelly's drive to know as much about autism as possible.
"I did a ton of research as his mom to make sure that I understood the diagnosis and was advocating for him appropriately. I was extremely involved with his team at school, I have many books on the subject and I know every autism website."
Growing Awareness about Autism in Young Adults
For Taylor, now 19, autism awareness hadn't been as prevalent and understood as it is now.
"He was right on the cusp of the big burst in autism awareness so his help at school got gradually better through the years. Elementary school was not great—in fact, I homeschooled him for 2 years; middle school was better and high school even more so."
"I know if we could find something that he loves to do, he would do it well. I will not stop until that is done!"
Taylor, right on the edge of the autism spectrum, has a hard time during his current transitional phase between graduating high school and what happens next.
"He can stay with our school district until he is 21 in a transition program, but it just is not a good fit for Taylor. The downside of autism spectrum disorders is that kids with all disabilities are often kept together. The higher functioning kids' abilities go unnoticed because attention is most often paid to those more challenged. He is gifted on some levels but this was not addressed because autism came before giftedness. Taylor has reached an age where he does not want to be affiliated with anything that labels him."
Building a Great Future
Kelly and her husband are working to help Taylor build a great future. "We want to enroll him in a computer class this fall to see if we can find his niche. The way he looks at the world, he just has to see why and understand how it all works. Taylor is a very kind, loving and smart boy; I know if we could find something that he loves to do, he would do it well. I will not stop until that is done!"
Helping Young Adults in Transition
How do you, as a parent, handle the transitional phase in your young adult's life? Provide tips, advice and suggestion in our comments section below or on the CaringBridge Facebook page.
If you or someone in your life is going through a health challenge of any kind, please start a CaringBridge website to share updates and fuel connection when it matters most.
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5 Replies
By Darla —
Kelly, thank you for sharing your story!! You are a wonderful mother and an inspiration to all of us!! I know that Taylor will have a successful future because you will all work together until he does!! Good luck!!
By Ann —
Kelly thanks for sharing your story. You and Taylor have been such a blessing to so many by sharing your story and wisdom, and I know he will find his path!!!! Love you all!!!
By Sona —
Taylor has a bright future. I can tell by the way you've approached everything about his (and your!) journeys. Your entire family are leaders and a gift to so many families that are following similar paths. Simply, you are amazing!
By Karen —
I have come to grips late in life that I am probably on that edge of the spectrum too. Feeling alone and different is the hardest part for me. I think computer classes will open up many opportunities for your son. There are so many ways to branch out, depending on what he likes to do….write, design websites, design apps, games, etc.
By Allison —
I am the adult child of a recently deceased parent. I fall about where your son does on the autism spectrum. My parents were both disgusted at the way our school district handled "difficult" kids, trying to kick me out of the school every chance they got. Middle school only got worse. My mom's biggest fear was realized: no supports for kids after high-school. I am 34, so autism was in the prehistoric state as far as awareness. As an RN, my mom had heard of the lower-functioning, "locked-in" autistic. Really, her biggest wish for me was to be happy and not let others define me by autism alone, but help me & celebrate my differences. I want there to be independent living for low-income individuals with ASD.

subset: commoncrawl


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Caput succedaneum
soft swelling caused by free fluid (oedema) on the head of a newborn baby at, or shortly after, birth - disappears rapidly
patchy brown pigmentation on face (like a mask) appearing in pregnancy due to hormone changes - also in women on contraceptive pill
chorion epithelioma
malignant tumour of chorionic cells usually after formation of hyatidiform mole complication
Cystic fibrosis
inherited disease which glandular tissue abnormal and, in particular, lung tissue becomes increasingly unable to function properly
Dermoid cyst
congenital (present at birth) sac containing embryonic tissue of hair, nails, teeth, skin etc.
Down's syndrome
congenital condition in which there is often severe mental abnormality together with physical features of a mongoloid appearance, large tongue and stubby hands (abnormality of chromosome 21)
Dysfunctional uterine bleeding
heavy menstrual bleeding which does not appear to have any anatomical cause
a condition in which fits occur as blood pressure becomes extremely high (danger to both fetus and mother, see pre-eclampsia)
inability of woman to become pregnant or man to fertilise the ovum (does not mean sterility)
first fetal stools - if passed in the womb it is a clear indication of fetal distress in labour
Munchausen syndrome by proxy
a situation where a child or other person is deliberately made to appear ill or suffer injury so that the person responsible gains attention
Polycystic ovarian syndrome
an increasingly common condition in women in which there are multiple, enlarged follicles of the ovary, together with high levels of testosterone (male hormone). A cause of infertility and also linked with Diabetes Type II
a condition during pregnancy where there is a raised blood pressure, albumin in the urine and oedema of the face and body (also known as toxaemia of pregnancy) - it precedes eclampsia
'monster producing' - a virus which is capable of producing deformities in the developing fetus


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All Posts In » 2011 » September » 03
Bioware wants your opinion on Bushoujo Liara Statue
I woke up this morning to see the Mass Effect page on Facebook asking what their fans think of Kotobukiya's Bushoujo Liara Statue. The pictures look like prototypes. The feedback on the Facebook page has not been kind. Many are calling out the pose, boobs, and face are just not Liara. What are your thought? Kotobukiya is famous for making anime versions of characters. Their DC line of statues have run from cute to way too much boobage. It's kindof their MO. Here is a picture of what the statue should look like in color from SDCC: What are your thoughts? Does it fit in with the character? Does it need to? Does it align with what the company makes? Would you buy it? FollowRead more →By GamingAngel in News 7 Comments »
PAX Panel: Infinite Respawn (hosted by The Married Gamers)
Saturday Morning 10:30am in the Serpent Theater I could be found on the Infinite Respawn panel with our friends @leftybrown and @mrsleftybrown from The Married Gamers on their Infinite Respawn panel. The topic was all about how gaming can be used to build up and strengthen our relationships with our partner. Other panelists included: Christa Charter (@trixie360), Dan Amrich (@oneofswords) and Zach Snell. As far as I know we don't have video from the panel, but below, you can listen to the full audio. Enjoy! FollowRead more →


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Alan K. Clarke
Mr. Clarke received a B.A., summa cum laude, from Morehouse College (Phi Beta Kappa), and a J.D. from Harvard Law School, where he served on the Civil Rights-Civil Liberties Law Review and was a research assistant for Professor David Wilkins. Prior to law school, Mr. Clarke worked in the Center for Executive Education at the Brookings Institution and also attended the Tuck School of Business at Dartmouth. Prior to joining the Office of the General Counsel, Mr. Clarke was an associate at the law firm of Choate, Hall & Stewart, LLP, where he focused on private equity transactions, mergers and acquisitions, venture capital financings and sports finance. At Harvard, Mr. Clarke advises on a wide variety of general corporate matters, including commercial transactions, real estate matters, international ventures and intellectual property matters.


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|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | Lounge | The Wire | Arcade
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Lol some fat bald idiot wearing a tapout shirt was trying to convince people at a cousins house to buy the "fight" saying it was gonna be amazing and it would be fight of the year. I streamed it and I must say it was the same as every other crap UFC ppv...total crap!
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Actually it was the best fight out of the whole card and they were just running around the ring trying to outbox each other most of the time. The whole event was really garbage. Its no surprise that most exciting fights and fighters in mma are fist fights which is what boxing is all about
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Mixed reviews on Lisbon-Sussex consolidation proposal
Town of Lisbon - Town Board members indicated Monday night they are getting mixed reviews from town residents regarding a proposal announced two weeks ago to explore consolidating the town and Village of Sussex into a city.
A public information forum is scheduled for Wednesday, April 4 at 6:30 p.m. at the Richard Jung Fire Station.
Town Chairman Matt Gehrke and Supervisor Dan Fischer said there is confusion about the proposal.
"I am getting some positive responses, but people need more information," said Gehrke.
Supervisor Dan Heier said the neighbors in his subdivision, located in the northwest corner of the town, have said if there is a consolidation they would prefer it be with the Village of Merton.
,"The knee jerk reaction is no, but after you explain it, some people say it makes sense," is how Supervisor Joe Osterman explained the reaction he is getting.
Supervisor Ryan Lippert said no one has contacted him regarding the issue.
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A Dollar General employee and another woman have been charged with theft after Amarillo authorities said they faked a robbery at the store last week.
The employee, Sarah Nicole Crisman, 20, and a woman identified by police as Breia Damaris Jicha, 31, were arrested this week after police said Jicha robbed the store at 2726 S.W. 10th Ave. on Jan. 13.
Crisman's account of the robbery did not line up with the store's surveillance video, leading investigators to look for another connection, Amarillo police spokesman Sgt. Brent Barbee said.
Crisman and Jicha were taken to the Potter County jail on a charge of theft over $1,500 and under $20,000, and Crisman posted her $3,500 bond, jail officials said. Jicha also had two traffic warrants, and remained in jail Thursday in lieu of a $5,000 bond, jail officials said.
Crisman told police Jicha entered the Dollar General about 8:15 a.m. Jan. 13. Jicha met her in an aisle, pointed a gun at her and demanded money, Crisman told police.
Crisman told police Jicha followed her to the store's checkout area and demanded money from the safe and one register, authorities said. Jicha then jumped the counter and fled out the front door, according to Crisman's account to police. No one was injured.
Barbee said after interviewing more witnesses, detectives learned the two women knew each other before the robbery.
Officers received Jicha's consent Monday to search her home in the 800 block of South Travis Street, and police seized an undisclosed amount of cash that could have been from the robbery, authorities said. Officers also found packaging from a toy gun in a nearby Dumpster, police said.
Police arrested Crisman on Thursday. She was arrested from a car that pulled up to a home in the 600 block of West Cliffside Avenue.
Barbee said Crisman was charged because she cooperated in the false robbery and received a part of the proceeds.


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In February 2010 a QIPP initiative to deliver Herceptin at home, saving £700k recurrently, was at risk of failing. Despite local CQUIN incentive for Trusts, there were barriers,(organisational, financial, emotional and safety) to working with a private sector organisation, Health Care at Home, through a Strategic Partnership with the West Midlands Specialised Commissioning Group. There was also a risk to other cancer services if the QIPP savings were not achieved through this initiative.
The Cancer Network and its Service Improvement Team were asked to support this work stream as a key priority. By focusing on improving the patient's experience of care, the Service Improvement Facilitator was able to bring together local teams to agree the appropriate care pathway, supported by IT and effective communication in accordance with Information Governance requirements.
This pilot demonstrated the feasibility of delivering home chemotherapy through effective partnership working between NHS and private sector providers.
In November 2009, as part of the plans for 2010/11 contract negotiations, the West Midlands Specialised Commissioning Group (SCG) identified delivering Herceptin at Home as a major QIPP project across three large provider units in Birmingham, Sandwell and Solihull. The intention was to add 'chemotherapy at home' to a range of 'out of hospital' initiatives being delivered through an established partnership between Birmingham East and North PCT and Health Care at Home.
As part of the contracting round, SCG agreed a CQUIN with the Trusts. The intention was to improve the patient's experience by offering choice and convenience, increase efficiency in day case units, struggling for capacity and generate savings for commissioners.
Healthcare at Home were selected to become the SCG's Strategic Partner to deliver this scheme and Herceptin was selected as the first regimen to be delivered in the home environment. This scheme was initially intended to run from April 2010 to March 2012 and the QIPP savings were built into the annual commissioning assumptions ie, PCT high-cost cancer drugs budgets were fixed on the assumption that £700k of recurrent QIPP savings would be achieved from this initiative.
The project experienced significant delays as objections were raised by the clinical and nursing teams in relation to the proposed patient pathway. These included the need for clarity around the responsibilities of acute provider and health care at home, governance, patient safety, additional work involved in patient selection, counselling and support.
Failure of the Herceptin at Home scheme would present a significant cost pressure to commissioners. The contract with Healthcare at Home was already in place, financial assumptions had been built around the savings being realised and there was a firm belief that providing patients with the option of care outside of hospital would be a significant quality improvement for patients and driver to modernise chemotherapy delivery.
Pan Birmingham Cancer Network and it's Service Improvement Team were asked to help ensure the project succeeded by working with Trusts to overcome the obstacles to delivering the proposed new care pathway.
The aim of this pilot was to test the concept, acceptability and effectiveness of a service that delivered Herceptin to women with breast cancer in their home environment, when historically patients would be treated in a hospital day case unit.
The objectives were to:
The Network Board supported the involvement of the Service Improvement Team.
A project steering group with representatives from NHS providers, Health Care at Home, Specialised Commissioners and the Network was set up.
A Service Improvement Facilitator was assigned to the project full time. Three working groups were established at Heart of England FT, Sandwell &West Birmingham FT and University Hospitals Birmingham FT. It was these groups that led the change programme across five chemotherapy units.
Leadership from the Network and Trust Cancer Managers was important to raise the profile of the project and the importance of success within each organisation. Trusts identified a local lead for each pilot site, while Healthcare At Home provided link nurses to each site and a clinical champion (Consultant Medical Oncologist) was identified for the Network.
A number of presentations regarding the aims and objectives of the pilot were made to the Breast NSSG, Chemotherapy Group, Patient and User Partnership Group and Trust Lead Managers. These were important to set the pilot in the context of a 'joint' service redesign initiative between the Network and Commissioners.
The clinical champion (an oncologist), along with the Network Pharmacist was key to ensuring that governance and safety associated with prescribing, compounding, and delivering chemotherapy, (Herceptin in particular) outside of a hospital environment were addressed for all organisations.
The principle of 'do once and share' was adopted throughout. In this way, where possible, processes and documentation developed in one organisation could be rapidly shared across all Trusts to achieve rapid adoption. The Steering Group was responsible for resolving local issues as and when they arose, and if necessary outside the formal meetings.
The groups quickly identified that a 'shared care' approach was required in order to ensure a seamless transition from hospital initiation of Herceptin (in conjunction with chemotherapy for adjuvant patients), to home delivery with planned cardiac monitoring at appropriate intervals.
Although the patients were to receive their Herceptin at home, the responsibility for offering choice, prescribing, dosing and routine cardiac monitoring remained the responsibility of the Trusts. Therefore it was essential that the Healthcare at Home Nurses were fully integrated into the multidisciplinary team and effective two-way communication be established.
Winning the hearts and minds of the clinicians, pharmacists and nurses was essential to ensure that local teams were engaged in finding local solutions to obstacles. It was important that the Trust staff had confidence in the home care team and that there was support for teams delivering care in patients home.
Throughout the project, the local teams met weekly. A 'team approach' was engendered to enable honest and open communication around areas where there were potential conflicts of interest, mistrust or barriers to the process. Although the Service Improvement Facilitator (and chemotherapy nurses) was aware of the CQUIN target and financial pressure to deliver the project, they were not directly involved in the contracting of Trust financial issues and therefore the SIF was able to provide an external, objective, facilitatory approach that focused on improvements for patients.
The SIF liaised with pharmacy representatives from Healthcare At Home to agree a common approach to prescribing, dispensing and administration protocols including handling spillage, etc. This was important to ensure patient safety and quality in line with national standards for peer review.
IT and information governance protocols were agreed and signed off by Trusts to ensure access to patient records was in accordance with Trust Information Governance requirements. Shared folders were established at each Trust to enable information to be accessible to both unit and Health Care at Home staff.
Honorary contracts were set up for Health Care at Home staff involved in the pilot to improve local engagement and training.
The patient information leaflet initially developed by Healthcare At Home needed to be revised to satisfy NHS standards for patient information. This leaflet was taken through the Network Governance process to enable rapid adoption by Trusts and to avoid local information governance committees.
Referral forms – both paper and electronic – prescriptions for Herceptin, anaphylaxis and pre-meds were developed along with a patient consent form for Health Care at Home to provide treatment.
A patient satisfaction survey was developed.
Once the clinical pathway for home delivery of Herceptin had been agreed it was piloted in one Trust first so that any issues could be resolved. For example:
In order to provide equity and make selection process easier, the commissioners agreed that the eligibility criteria could include these patients.
Communication was essential to ensure all stakeholders were aware of the pilot and the benefits to patients. This included letters to all GPs whose patients were receiving home care, briefings to Network site-specific and user partnership groups and a launch event to ensure that there was clarity around roles and responsibilities for each step on the pathway.
Because of the work involved in setting up the pilot, the start of the pilot was delayed from March 2010 to June 2010. However, the pilot continued beyond the end of the 2010/11 financial years.
At the end of the pilot phase 100 per cent of eligible patients were being offered the choice of Herceptin at home. By February 2011, 61 per cent of eligible patients in the Pan Birmingham Cancer Network opted onto the Herceptin home care pathway. Uptake varied between trusts ranging from 58- 65 per cent.
The patient satisfaction survey indicated that 100 per cent of patients on the home care pathway were more than satisfied with the care they received.
Uptake of the home care option steadily increased as Trusts became confident with the pathway and trust grew between NHS and Health Care at Home.
All Trusts achieved their CQUIN target
Commissioners saved £660k by the end of 2010/11 financial years.
The pilot continued to be delivered by Health Care at Home through the contract during 2011 after which Trusts were required to develop their own home care solutions.
The pilot proved that home care delivery of Herceptin was feasible and acceptable to patients and was used as proof of concept for home chemotherapy.
The pilot demonstrated that it is possible for NHS and Private Sector providers to work in partnership to deliver care to patients.
IT access between NHS and private sector providers can be achieved both physically through N3 connectivity, and legally through information and clinical governance checks and adherence to set organisational and national standards. These solutions rely on willingness of IT departments and Information Governance leads to work together with the private sector.
This pilot has demonstrated the feasibility of safely delivering chemotherapy outside hospitals and in patients' own homes. The pilot also demonstrates that it is possible to work in partnership between NHS and private sector providers to deliver a seamless care pathway for patients.
The pilot highlights the fact that the contracting process, even if supported by financial incentives (CQUIN), is not the only lever for change. Clinical Teams needed active support through meaningful stakeholder engagement and team work (involving commissioners, clinicians and patients) to deliver rapid and sustainable change.
After a difficult start, within six months, five chemotherapy units in three acute Trusts were delivering Herceptin at home to 61 per cent of eligible patients.
The biggest impact of this pilot was on the quality of care for patients. Patients were given a real choice of location and convenience in terms of time of treatment. Patients could opt for home care in the knowledge that their care was being delivered by a team who were fully integrated with the hospital team and that they could return to hospital treatment if unhappy with the home care option. Patients also benefitted from 1:1 nursing care.
The next biggest impact was on NHS staff. Despite the added work involved in offering and supporting patients onto the home care pathway, chemotherapy nursing staff and pharmacists were happy to work in partnership with the Health Care at Home staff. A culture of mutual respect and trust grew out of the local team working to deliver the pilot. As a result of the pilot, all three Trusts established a range of materials, protocols, IT solutions, governance frameworks on which to base future home care services. Capacity pressures within chemotherapy units were relieved.
Finally there was a significant financial advantage to Trusts in achieving the CQUIN targets and to commissioners in realising the £660k QIPP target.
The partnership with Health Care at Home continued through to 2012 when Trusts were able to develop local home care services or put the service out to tender.
The project steering group received a monthly report which identified the number of patients that were clinically suitable to receive Herceptin at home; the number expressed as a percentage that opted for home care. This was segmented by Trust.
The monthly report also included an analysis of the reasons given for not choosing the home care option – to identify trends and address concerns to encourage uptake if appropriate.
A survey of all home care patients was undertaken to ensure patients were satisfied with the home care option. The level of satisfaction was extremely high and patients who opted for home care found it the most convenient.
Although a lot more work was required on the part of NHS Staff to identify and support patients on the home care pathway, there was positive feedback from NHS staff regarding the pilot and the choice this gave to women.
Although not part of the pilot evaluation, the Trusts involved in the pilot did satisfy the CQUIN requirements and receive the associated payment.
Commissioners did achieve £660k QIPP savings, which were reinvested in cancer services. The savings were developed through reduced drug wastage, reduced VAT and lower overhead costs of the homecare system.
Programme Lead for Cancer and HIV
Midlands and East Specialised Services Commissioning Team


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------Indecision may or may not be my problem. -Jimmy Buffet
------2009-113.25 yds
2012 86.3 yds..
2013 21.0
Everyone who sews seriously has a stockpile of fabrics, because it is natural to purchase more than can be sewn in any one season" Singer, Timesaving Sewing, 1987
------Sewn in 2012: 176.212 yds.
Total sewn in 2013 -- 225.848 yds.
Total sewn in 2014 -- 143.255 yds.
Total yards in inventory 1/1/16 -- 1857.086
Goal for 2016 -- 400 yards
Machines: Designer Diamond, #1+, H Class 100Q, Viking 400, Brother XR65 -- Serger: 936 -- Singer Coverstitch
------"Play the cards you are dealt, but choose who is sitting at the table"..AARP magazine
SEE MY ETSY SHOP HERE: http://www.etsy.com/shop/AuntMaymesAttic
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The Dome became a time machine last Friday evening, teleporting themselves and their fans back to the 90's. Check out this mega-photo post of Syracuse's Throwback Uniforms from their 12-10 victory over #2 Virginia.
Although their uniforms were old school, their gear was anything but. From orange and blue chromed STX heads, Nike Flywire technology cleats, Nike Vapor Elite gloves, to Cascade CPX-R's, Syracuse is not only on top of the lacrosse rankings, but also on top of the swag world.
Thanks to Greg Wall and Ty Xanders for all the great photos of gear, behind the back goals, hair styles, and much more. Watch the highlight video and when you're done checking the post out view this amazing throwback video of Syracuse vs North Carolina in the 1993 National Championship.


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TRENTON — The council chambers at City Hall was filled to overflowing yesterday afternoon.
Every chair was taken, forcing dozens to stand three deep against the walls and even sending a few into the hallway. The crowd of loved ones, friends and future colleagues were all there to celebrate the graduation of Trenton's first new firefighter class since 2009.
"This is an honor, to be in front of these gentlemen, to send them out to protect the citizens and property of the city of Trenton," said Battalion Chief Robert Tharp, who supervised the training of the 18 recruits.
The men who graduated from the 13-week training course will be starting work as soon as tomorrow, augmenting a department whose numbers are low from retirements.
"I feel great, I feel just ecstatic, that here is the first fire class in three years," Fire Director Qareeb Bashir said.
With Mayor Tony Mack out of town amid an FBI investigation, acting mayor Sam Hutchinson offered a firemen's prayer poem and gratitude to the city's newest employees.
"On behalf of the mayor in his absence, thank you for answering the call to serve, thank you for answering the call to protect, and thank you for answering the call to respond," he said.
Final course scores for the graduates were excellent, Tharp said, with no one scoring below an 84 out of a possible 100 points.
"These candidates and recruits met the call," he said.
Joseph Szabo was named class valedictorian, while Joe Deacon took the award
for physical fitness.
Family ties run deep in the Trenton fire department.
Joseph Szabo became a firefighter yesterday along with his brother Michael, and both had their badges pinned on by Gary Szabo, a Trenton firefighter who retired last year.
New firefighter Fabian Figueroa was welcomed to the job by his brother Ferdinand, who has been a city fireman for six years, as was Michael Mihalik by his namesake father, a member of the city's Ladder 4.
Stephen Muni kept a long-running tradition alive by becoming a firefighter. The city's fire service has had a Muni on its rolls for 100 years, Tharp said to a burst of applause from the audience.
Also during the ceremony, Notre Dame's John McKenna was named the fire
department's official coach and presented the white helmet chiefs wear.
McKenna, the strength coach at the school, volunteered his time to put the recruits through grueling physical training that involved everything from flipping truck tires to kettle bell exercises.
"He really, truly takes the calling of pay it forward," Tharp said.
The full list of graduates is: Angel Castillo, Ahmed Clark, Khalid Davis, Joseph Deacon, Christopher Field, Fabian Figueroa, Emmanuel Guerra, William Harris, Willie Jackson, Melvin Melendez-Vazquez, Michael Mihalik, Eric Miller, Stephen Muni, Andres Perez, Jose Santos, Joseph Szabo, Michael Szabo and Theodore Williams.
Contact Alex Zdan at email@example.com or (609) 989-5705
Follow the Times of Trenton on Twitter.


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An arson investigation is under way in Sacramento County following an apartment fire Tuesday morning.
Smoke was seen coming from a third floor unit at the apartment complex in the 3500 block of Watt Avenue.
Firefighters are calling the fire suspicious because the apartment was vacant.
Investigators remained at the scene Tuesday morning at the Arcadia Apartments.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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New Website for the imprisoned Eritrean Patriarch - Printable Version
+- The British Orthodox Church - Fellowship Forum (http://britishorthodox.org/forum)
+-- Forum: News & Events (http://britishorthodox.org/forum/forumdisplay.php?fid=10)
+--- Forum: News and Events (http://britishorthodox.org/forum/forumdisplay.php?fid=9)
+--- Thread: New Website for the imprisoned Eritrean Patriarch (/showthread.php?tid=143)
New Website for the imprisoned Eritrean Patriarch - Severus - 17-09-2007
May I draw your attention to the new website "Restore Patriarch Antonios to his throne" which is to be found at http://abuneantonios.com
Among other things, it contains full video footage of the meeting of Prayer and Reflection for Patriarch Antonios held in London on 27 June 2007.
The Petition to the President of Eritrea expressing concern for the Patriarch's well-being is now also available online and we hope you will sign it and encourage others to do so.
This also provides an avenue of contact with the Organising Committee for those interested in expressing concern and wishing to be associated with this honourable and just cause.
We hope to provide up to date news as it becomes available.
Please support this site.


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Trespassing Journal is a new, fully peer-reviewed biannual journal that is committed to publishing fresh and original research in the fields of artistic production (including literature, film, new media, video-art, fine arts, experimental and avant-garde art, etc.) that trespass the sacrosanct grounds of the theoretical and artistic disciplines, and also question the established boundaries between art, science, and philosophy.Trespassing Journal focuses on artistic misfits, art and politics, artistic production in exile, and contradictory realms where art and technics break away from conventions.
Trespassing Journalaccepts relevant book and film reviews on recent books and films for its inaugural issue on 'Trespassing Nation'. Potential contributors are invited to submit a book or film review (700-1500 words in MLA style), along with contact information to the editors by 15 November 2011.
For more information please contact the editors at firstname.lastname@example.com and visit the journal's website http://trespassingjournal.com/


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St. Matthews police evacuated Brown Park Wednesday afternoon after a suspicious package was found there.
Police also closed Browns Lane, Hubbards Lane and Bowling Boulevard while the package was inspected.
"I know that they used all the means that are necessary for them to determine that," said Dennis McDonald with the St. Matthews Police Department.
Police reopened the park about 7 p.m., after it was determined the package did not pose a threat to the park's visitors or nearby residents.
The bomb squad will now dispose of the package, the contents of which were not released.


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Here's a look at the concussion test athletes have to pass
October 28, 2010 - Cory Giger
I took the ImPACT concussion test Monday at St. Francis University and prepared this detailed graphic. It shows the interesting and peculiar elements of the test, such as word and squiggly line memorization, color recognition and response time. Click the link to the right to see my story and to check out the test. We hear about concussions all the time -- and will continue to for many years as we gain further information -- and this little graphic gives a good indication of the things doctors are looking for in evaluating a concussion.
Blog Links


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Many times during her first two seasons with the University of Louisville women's basketball team, coach Jeff Walz preached to Antonita Slaughter about what she could do to help the program.
The former Christian Academy star showed flashes of being a solid player, but averaged just 3.2 points as a freshman and 4.7 as a sophomore.
Now, a junior and Slaughter seems to have turned the corner. Heading into Friday's game at Colorado, Slaughter has become more aggressive and assertive on the floor and has turned in some solid games.
"It's focus and her approach to the game," Walz said. "She's played great for us lately and she has to keep playing like that. She can do it."
Slaughter, who leads the team at 35.5 percent from three-point range this season, had a team-high 13 points with four rebounds and three assists last weekend in a blowout over Valparaiso.
While her averages are just 5.5 points and 4.6 rebounds, Slaughter has seen her numbers rise in the past five games and said it's because of confidence.
"I think I am just more confident," Slaughter said. "I think my team has started to have confidence in me. I just need to come out and performer just like that every night now. I feel like I am playing a lot better."
Slaughter is averaging 18.5 minutes a game and has hit 11 of 31 three-pointers, while hitting 38 percent overall from the field.
Walz said Slaughter, who hit around 35 percent from three-point range each of her first two seasons, can still get better, especially from long range.
"If she would just dedicate herself and say, 'You know what, I am going to be a 40 percent three-point shooter,' she could do it," Walz said. "She has to be making 200 three-pointers a day. She has to dedicate herself before and after practice.
"She can do that and hopefully she realizes it."
But Walz admitted Slaughter has "come a long way," from the beginning of the season and certainly since last season.
"She just needs to continue it," he said.
Slaughter will likely be needed to perform at a high level on Friday, The Cardinals will be without Sara Hammond, who will be home in Mount Vernon, Ky., after death in her family this week.
Slaughter came to U of L after an All-State career at Christian Academy. Her sister, Toni, is former U of L player and her brother, A.J., was a standout player at Western Kentucky University.


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Max Payne, the eponymous gravel voiced "anti-hero" has returned after a hiatus of nearly a decade. Developed by Rockstar Studios, the latest game features a change of location, a new story and a number of fresh elements.
When Max first burst onto the 3D shooter scene he delivered new features and a fresh, adult story. The original Max Payne easily stood out as the most innovative 3D shooter of its age and spawned a superb sequel as well as a gaggle of imitators. In particular "Bullet Time" - the ability to slow down enemies and make precise shots - was a huge innovation and has been copied often.
Fast forward to the present day and much has changed. There are now many top notch shooters, most of which have features that help them to stand out in the current hyper competitive climate. In this tough new world does Max still have the skills to pay the bills?
When you fire the game up for the first time the lavish production values and strong narrative will bowl you over.
That said Max Payne 3 delivers a tale of woe that isn't quite as compelling as the original game. Max has fled New York to pursue a new life as a hired bodyguard in Brazil. As soon as he has landed the fecal matter hits the spinning air conveyance facilitator and one of the people he is hired to protect is kidnapped. From here Max quickly discovers his employers are not popular people and he is constantly chasing hordes of bad guys as he tries to get to the bottom of the vendetta.
The story has many twists and turns and it moves along nicely, but it doesn't have the emotional impact of the first game which saw Max trying to avenge the murder of his wife and baby. You still find yourself caring about the sad old veteran though, even as he binge drinks his way through most of the artfully animated segues.
Bullet Time has returned and we still like it, but there are other features that clamor for your attention. The game delivers a new obstacle based cover system, as well as a "last man standing" shoot-out mode that sees you survive a near fatal hit if you can fire back successfully. This mode is really cool as the game employs clever blur effects to make it feel like you really are about to expire if you don't blast the guy who just shot you.
Max Payne 3 also features a number of fun multiplayer modes and these do add something, even if for this particular shooter the single player game is still king.
Slumming itThe game keeps you guessing with helicopter sniper stages, swamp boat chases and flaming buildings to escape as well as some really cool set piece battles with enemies and boss characters. The action is also punctuated by superb visuals. Never has the nebulous maze of refuse and ramshackle housing of Brazil's favela neighborhood looked so good.
The animation is not perfect though. During the swamp stage we managed to break the scripting and enemies simply stood on their stationary boats and didn't die when shot. A quick reload fixed this thankfully.
Max has a good, but not great selection of weapons to play with this time around. Compared with the earlier releases the current offering lacks variety boomstick wise. You do get to use an excellent sniper rifle from time to time, but you can never keep it. Instead it is sometimes snatched from your inventory in a way that doesn't make sense. Indeed this applies to all of the weapons in that, after some passages of play, you lose your guns with no real explanation. This hurts the narrative's sense of credibility, as Max wouldn't have just tossed such valuable firearms away. He loooves his guns!
Also while the gameplay is very good, for us the essence of any Max Payne game should be Bullet Time. In the current offering the cover system ends up being the most regularly called upon gameplay dynamic and this feels odd.
During some stages Bullet Time is for the most part unnecessary. It isn't driving the gameplay forward as it did in the earlier incarnations of the series. It has gone from being the turbo, giving the game its extra impetus, to being a mere hood ornament. You will kill enemies more efficiently and with less risk to yourself by simply propping behind cover and popping up to take shots when foes show themselves.
Shoot Dodge issuesBullet Time, and in particular "shoot dodging" works, but it can be quite risky too. At its best shoot dodging is all about leaping into the air, spinning around and blasting a bunch of hapless enemies as they flounder about in slow motion. Bodies fall and you survive because of your incredible acrobatic skill. In Max Payne 3 your agility is annoyingly hamstrung. You can't draw a bead on foes fast enough. Worse than this, you often land with a thud that sees you recovering too slowly, leaving you horribly vulnerable. So while it looks really cool, you will use shoot dodging sparingly, as popping away at bad guys from cover is more effective ... it just doesn't look as exciting. Even with the aiming speed cranked up to maximum the game still lacks the dizzying speed and precision we'd expect.
Too much of a good thingAlso, and I know we are nitpicking here, many of the segues feature colorful motion blur visual effects that are totally unnecessary. The game looks stunning enough without this additional graphical garnishing. For us the developers were at times self indulgently showing off their luminescent toys merely for the sake of it. Sometimes more is less. On the other hand, the rag doll system and facial animation sets a new standard by which Xbox games should be judged. It is really incredible.
Fans of the ketchup will be far from disappointed as the game splashes it around with enjoyable abandon. You also get treated to an animated slow motion kill sequence when you have polished off the last foe from a group of bad guys and some of the finishing moves in melee combat are slicker than baby poo. If this wasn't enough the lighting effects and sun flares are also delightful to behold.
So, while there has been much discussion in this review of the things we didn't quite love about this game, Max Payne 3 is still well worth your time and spare shekels. Indeed, it is only because we love the game so much that we feel the need to be picky with our critique. Max Payne 3 is that close to being perfect that we'd love it to have those few remaining foibles sorted.
The verdictFans of the previous two outings will enjoy this and those of you who have never played a Max Payne game will love the acerbic wit, style, and narrative depth of the game. The game delivers old school ballistic bliss with aplomb. Gun toting gangsters and militia are everywhere and the action just keeps propelling you forward.
Thankfully videogame veteran Max hasn't succumbed to old age and "lost it" like a certain Mr Nukem we'd rather not mention.
Image source: Rockstar Games


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The main focus of the Becker lab has been on the mechanisms and consequences of post-ischemic myocardial inflammation.
We have found that the acute inflammation accompanying myocardial infarction begins shortly after reperfusion and enlarges the area of irreversible injury. Limiting inflammation by various means, such as with antibodies or drugs, can reduce infarct size and improve left ventricular function. Inflammation begins with conversion of endothelial cells in the ischemic myocardium to a pro-inflammatory phenotype, with increased expression of leukocyte adhesion proteins, such as intercellular adhesion molecule-1 (ICAM-1), and microvascular trapping of neutrophils with accumulation in the myocardium.
ICAM-1 gene upregulation in the post-ischemic myocardium is mediated by tumor necrosis factor [alpha] (TNF[alpha]) through the NFkB pathway, but also by activation (phosphorylation) of the transcription factor Stat3, bound to the transcriptional activator Sp1. Stat3 is phosphorylated in turn by interaction with Rac1, an essential subunit of the endothelial NADPH oxidase, through a novel multiprotein complex involving Stat3, Rac1, and protein kinase C (PKC).


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By From staff reports
Published in Sports on May 18, 2011 1:47 PM
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Reason for Wii shortageFor everyone who complains about Wii shortage, here is my two cents. Take a look at this chart.http://vgchartz.com/hwlaunch.php?cons1=Wii®1=All&cons2=DS®2=All&cons3=PS2®3=All&weeks=156This chart shows accumulated sales number from launch for three of most popular game devices of all time: Wii, DS and PS2. If you were planning production for Wii, what would you have done? You look at PS2 which still is the best selling console of all time and make more than PS2 or make few million and see how sale goes and increase the production. If you remember when Wii launched, everyone expected it to end up last place after PS3 and Xbox 360. About stock splits, why would you be happy to get 4 quarters for a dollar bill? Warren Buffet never split his stock and he seems to be doing well. Nintendo is a conservative company. They plan to be around for next 100 years and not blow themselves up like all the banks or dot com companies few years back. If you want to invest your money on companies that spends 18 million dollars for 3 weeks of work, you can, but don't bash Nintendo for trying to save money for shareholders.
Sony made enough PS2 that they were on the shelf when a customer wanted to buy one, except maybe the week before December 25th. Nintendo is not making enough Wii to keep them on the shelf in September. Since the product is not on the shelf customers are not able to buy it. Last holiday season Reggie estimated that Nintendo missed a billion dollars in sales. Reggie is a VP of Nintendo. If a company fails to meet demand for their products year after year then their sales are lowered. Investors use sales as a metric of stock valuation. If sales are lower then earnings are lower. Investors use earnings as a metric of stock valuation. Lower sales and earnings mean lower share price. Investors typically prefer higher share prices.Right now an investor in Japan wanting to purchase 7974 must put up the equivalent of about $45,000. Most small investors just don't have $45K to plow into one stock. In all other stock markets an investor must purchase shares on the equivalent of the pink sheets. These shares are backed by banks. Have you noticed any news regarding banks lately? Many small investors are not sophisticated enough to read thru quarterly statements and balance sheet. Yet to make an investment decision regarding a stock on the pink sheets the only source of information is quarterly statements and balance sheets. This limits the number of investors holding Nintendo shares. If there are fewer investors, the share price will be lower and more volatile.
If I remember correctly, Sony dropped price of PS2 from $299 to $199 after about two years and Wii is still at $249. Nintendo is making more Wii now than Sony ever did with PS2 and you are complaining about 1 billion in sales Nintendo may or may not have made last year? Of course it would've been great to get that extra 1 billion in sales, but that would've meant capital spending to increase production and lower margins. With economy slowing down, Nintendo may have too much inventory by now and forced to cut prices on Wii or even worse lose money on Wii. Currently, only US is experiencing shortages and even that may disappear after this holiday season with current production number. What if Wii is just a fad and nobody wants to buy them next year would you prefer explosive growth for two years and crash and burn or steady growth for years to come? Take a look at all the banks now. They were making big bucks few years ago betting housing prices will go up forever, but the party ended and now nobody is around to clean it up.Yes, I agree $45,000 is a lot of money to invest into just one stock for us mortals, but that's about price of a nice car and I see a lot of people driving car that costs more than that. If you want to invest $45,000 on a stock, you are not going to just jump in and out for quick profit. Nintendo wants that stability. They don't want to chase some hot trend and burn money. They want long term growth. If they split their stock it will likely attract those kinds of investor who wants quick growth and even quicker profit. There are a lot of stocks that trade below $5 and then there is Berkshire Hathaway (brk-a) which trades $135,000 a share. Berkshire used to trade $45,000, but that didn't stop people from buying them. If company is doing well and shares are reasonably priced, no matter what the stock price is people will buy it.I am not going to pretend I know what will happen to NTDOY or stock market because I don't know and nobody does. All I know is that conservative company like Nintendo won't be likely to get into trouble like all the banks are in now and will likely be around for a long time. They employ some of the most creative people in Japan and have been successful by being different. I think they will be successful for number of years to come. Just try to buy it when it's cheap and collect the dividends. In few years, who know what they will come up with next?


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Average Ratings
4 out of 4 people recommended this car.
Consumer Reviews
very nice vehicle
by truckmanbear from | August 19, 2011
Ive had the truck for about a few years. great truck nice perks. Ive installed a custom sunroof and a custom hood scoop. in all the truck preforms great. ice cold a/c. The only thing about the a/c is that it sometime switches from front vents to the window vents. which is weird. but all in all its a great truck.
Purchased a new car
Uses car for N/A
Does recommend this car
1995 Dodge Ram -213K still going
by Love My Truck from Arkansas | July 29, 2010
I bought this truck used to move from Georgia, to Arkansas. By the time I got to Arkansas , three day and two overnights at rest stops due to weather,later I was sold on the truck. This truck was a trooper, hauling a 17 foot Uhaul, three cats in the back, through , heavy rain, snow,and ice gave me no trouble. I am commuting 250 mile a day , still running fine, used 14 gallons, so about 18 MPG with the A/C full blast. The only down side I have is , one the front chrome grill is actual a piece of metal foil, and is bubbling up, two the worst cup holder, so shallow most cup jump out the frist time you hit a bump.
Purchased a new car
Uses car for Just getting around
Does recommend this car
very dependable truck!
by truckboy from | September 14, 2009
I've had a 1500 for quite some time & it just keeps on going like the energizer bunny! If you keep them well-maintained, they will run forever.
Purchased a new car
Uses car for N/A
Does recommend this car
will not quit !!
by hunter from Los Angeles | October 24, 2007
The 95 Dodge diesel dually I have has 312,000 REAL miles, city and major higway driving. It has done a 4000 mile, nonstop road trip every year since new, without any problems or breakdowns. Great fuel economy, and plenty of room for me ( 265 lbs) 6'-8".
Purchased a new car
Uses car for N/A
Does recommend this car
Featured Services for this Dodge BR1500
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Hi! My name is Flurry
I am Domestic Shorthair from Collinsville, VA
Nicknames: Flurry Girl
Age: 9 years old
Gender: F
Coat: short haired
Education: The bottom of her brain did not develop right so she has had to adapt to a wide walk and problems judging depth. She does wonderful now!
My favorite tricks and treats are: she walks on a leash outside and she loves greens as well
Where I hang out: in her box
My favorite grubs: she loves cheese
My pet peeves: she hates anything loud
What I love about my owners: affection
My cat hobbies: play sock
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EDITORIAL: Stop new reality show!
The Republican presidential candidates are now vying with each other to see who can bash immigrants the hardest. Those who in the past have appeared more pro-immigrant are now jumping on the bashing bandwagon.
EDITORIAL: American coup anniversary
The following is excerpted from a People's Weekly World editorial on the Dec. 12, 2000, Supreme Court decision re: Bush v. Gore, which started on page one of that edition. As we head into the 2008 presidential elections, we reprint it here to commemorate the seventh anniversary of a "very American coup."
Report: Step up fight vs. AIDS among Latinos
CHICAGO — Last October the Greater Humboldt Park Community of Wellness, a coalition of health-related groups here, released a report titled "A Call To Action: Regarding HIV/AIDS Among Illinois' Latino Communities" that investigated the community's current response to the disease.
Striking screenwriters refuse to surrender
Those who think it is only a matter of time before striking screenwriters cave in to the Hollywood producers are not getting what this strike, now supported by two-thirds of the public, is all about. This point was made clear Dec. 7 when talks between the writers and producers broke down.
Civil rights leaders demand foreclosure halt
NEW YORK — Outside the New York Stock Exchange Dec. 10, holiday music competed with the chants of "Save our homes!" A few yards away from the Wall Street Christmas tree display, hundreds of protesters gathered to demand a swift and decisive response by government and big business to the growing subprime loan crisis sweeping the nation.
EDITORIAL: Shopping & dropping
"Black Friday" has become a peculiar American institution. Retailers have promoted the day after Thanksgiving as the opening of the holiday shopping season, counting on this day to roll in a good percentage of their yearly sales — to get them out of the "red" of loss and put them in the "black" of profit.
GOP recruits millionaires to replace those who fly the coop
NEW YORK — Republicans are hoping to retake control of Congress by recruiting right-wing millionaires to run for office in districts now represented by pro-labor and antiwar representatives elected in 2006.
Home foreclosures are now at 2 million per year: What you can do to save homes
Home foreclosures will remain at the rate of 2 million per year well into 2008. Before the crisis is over, 3 million families — homeowners and renters — may have been kicked out of their homes, often losing everything in the process.
Grabbing food from mouths of babies
WASHINGTON — This is the season for feasting and good cheer. But President Bush, like Ebenezer Scrooge, is waging a mean crusade to force more than half a million poor women, infants and children off the WIC nutrition program.
Fortresses of working-class power
A nightmare for progressives leading up to the Nov. 7 elections was that Maryland voters would go against the grain and elect Republican Michael Steele, an African American, to the U.S. Senate seat held by retiring Democrat Paul Sarbanes.


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Rebecca Minkoff Guest Blogs for Saks on her obsession — Nail ArtCome See Rebecca at Saks on Fashion's Night Out in New York on September 6!
Minkettes, SaksPOV readers, fashion lovers, I'm here guest blogging for Saks to talk about the perfect way to transition to fall fashion — even if it's not quite sweater weather yet. It's all about nail art! Nail art is an easy, cheerful way to play into a just about any trend on the runways — and it's totally accessible too.
I'll be making an appearance at Saks' flagship Fashion's Night Out (be sure to stop by it you're in the neighborhood and see the entire FNO schedule at Saks here!). We'll be there with the fashion girls' favorite, Valley Nails, doing manicures inspired by our prints for fall.
Check out my favorite nail art manicures of all time, courtesy of Valley Nails:
Solar powered: (Left) This mani gives you the sun, moon and stars. Totally outrageous!
40 Licks: (Right) This dusty blue base color lends itself perfectly to the surprise of the iconic Rolling Stones logo.
Blue period: (Left) Shades of blue are so elegant and chic — especially when popped with spots of gold.
Have fun with nail art! (Right) Don't be afraid of color and show your wild side. Love this tie-dye look!
Also, here are some of my favorite polish colors for fall:
From left: Nars in Purple Rain, Le Métier de Beauté in Hope Diamond Blue, Estée Lauder Pure Color Nail Lacquer in Chaos and Dolce & Gabbana Intense Nail Lacquer in #121 Passione
See the entire FNO schedule at Saks here.
Check out Rebecca Minkoff's fall collection on Saks.com.
Read about Fashion Indie's collaborations with SaksPOV and Valley Nails here!
Show us YOUR nails! Tweet a picture of your manicure to @Saks. Need inspiration? Visit our 'Nails' board on Pinterest!


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Risks multiply as Afghan poll run-off nears
22 May 2014 - 0:13
KABUL: Both candidates vying to be the next president of Afghanistan are convinced they will win and that only cheating can stop them -- setting the stage for a fraught election when campaigning starts Thursday.
Abdullah Abdullah and Ashraf Ghani are locked in a head-to-head battle that could test Afghan stability as the country chooses its first new leader since the tumultuous days after the Taliban regime fell in 2001.
As the drawn-out election process builds to a climax, US-led combat troops are closing bases and withdrawing rapidly, with all remaining 51,000 Nato soldiers due to exit this year after more than a decade fighting the Taliban.
The first-round election on April 5 was hailed a success by Afghan officials and foreign allies after the insurgents failed to launch a major attack, and fraud though widespread was deemed not to have affected the outcome.
Abdullah and Ghani, the two top vote-winners, progressed through to a run-off vote on June 14, with some observers fearful that the campaign could be antagonistic and that the final result may be disputed.
"The worst-case scenario would be if the election is both polarising and the results are not accepted by one of the candidates -- that has the potential to lead to conflict," Nicholas Haysom, deputy Unied Nations mission chief, said this week.
"The remedy to that is to make the election as transparent as possible."
Many Afghans fear polling day will be targeted by the Taliban as the date falls at the height of the traditional "fighting season", presenting the insurgents with a timely moment to grab back the headlines.
"A second round gives an opportunity for a much more effective and complete democratic exercise to choose a leader," Haysom said. "But it comes at a risk."
He added that the United Nations had appealed to both candidates not to campaign "in a manner which promotes the risk of ethnic tensions and violence".
Ethnic divisions have blurred in Afghanistan to some extent since 2001, but tribal affiliation remains a key factor in voting preferences.
Abdullah attracts much of his support from the Tajik ethnic minority and other Dari-speaking groups in the north, while Ghani is a Pashtun, the largest ethnic group, which is strongest in the south and east.
President Hamid Karzai, who must step down after serving the maximum two terms, retained power in 2009 in a fraud-riddled election that nearly derailed the multinational effort to develop Afghanistan.
A close election next month could revive the tensions and bitterness of 2009, when Abdullah dramatically pulled out of the run-off after massive cheating by Karzai's supporters.
"If the second-round is tainted by fraud, it would be extremely dangerous for a country like Afghanistan," said European Union election observer Thijs Berman, who described fraud in the first round as "substantial".
"Any fraud is a threat to the security of Afghanistan and its future. It is essential that there is a peaceful transition of power." Berman criticised Afghan election authorities for releasing "late and incomplete" data after the first round, and he said better transparency was essential in the run-off.
Since the second-round timetable was declared last week, Ghani has been tweeting about new allies joining his team while Abdullah has spoken of his priorities when he moves into the presidential palace.
With neither contender likely to concede without a fight, the election process that began in early February could hold more surprises before final results of the run-off are declared on July 22. AFP


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How to find FFL to transfer firearm
Social Situations
General Gun Discussions
> How to find FFL to transfer firearm
March 4, 2006, 12:36 AM
Any THR FFLs to transfer firearm into Tulsa?
If you enjoyed reading about "How to find FFL to transfer firearm" here in TheHighRoad.org archive, you'll LOVE our community. Come join
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March 4, 2006, 02:45 AM
Go to www.gunbroker.com and click on the "for buyer" tab then scan down to find a link "find a transefer dealer." Hope this works for you.
March 4, 2006, 06:36 AM
March 4, 2006, 10:26 AM
that will work!
Jim K
March 4, 2006, 11:43 AM
I suggest using the phone book. But before that, why not make friends with some local dealers? Buy things from them. Get to know them and vice versa. Learn how they feel about accepting shipments and what they charge for the service.
A dealer doesn't appreciate some guy he has never seen before swaggering in and demanding that the dealer handle a transfer for him, then ranting about the charge (it happens more often than you might think). Some dealers tell people they don't know or have never seen that they don't do transfers, or they jack the charge way up. Good customers, on the other hand sometimes will not be charged a fee at all for a simple transfer.
Also, by learning to know local dealers you can meet people who are, by and large, good folks. You can sometimes get in on some good deals and see what you are buying, something you can't do on the internet.
If you enjoyed reading about "How to find FFL to transfer firearm" here in TheHighRoad.org archive, you'll LOVE our community. Come join
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Take a look at some of the best in photographs sent to the Suburban News during the week of Nov. 11-15, 2013.
Things to do in Union County on Monday, Nov. 18
• Interview preparation is much like preparing to be on the stage — the more you practice, the greater your comfort level and performance. Interview expert Alex Freund invites job seekers on Nov. 18, at 6:30 p.m., to do mock interviews and experience the four elements the interviewer is targeting. Freund founded Landing Expert Career Coaching in 2005. This program is presented by the Scotch Plains-Mountainside Public Libraries' Career Networking Group. It is free and open to all interested participants. Register online at scotlib.org., call 908-322-5007, ext. 204 or email email@example.com.
Have an event or photo you would like to share with the paper and your community? Send it to us at email@example.com and we will run it in print and post it online.


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LISBON — A Salem man already charged in two other criminal cases, including arson for five vehicle fires, was served Wednesday with a secret indictment for another felony count for allegedly breaking into a convenience store.
Jacob Arkwright, 19, of 1020 Homewood Ave., was charged by the Columbiana County grand jury last week with breaking and entering, a fifth-degree felony.
Court documents alleged Arkwright trespassed in Sami Quick Stop on West Second Street in Salem on Jan. 20.
Arkwright was indicted by the last grand jury at the beginning of May for one count of burglary, a second-degree felony, and theft, a fourth-degree felony. Documents alleged that he and a co-defendant trespassed on the property of Jan Liston on North Union Avenue in Salem on March 28 and stole an all-terrain vehicle belonging to Liston.
He was indicted earlier this year for five counts of arson, a fourth-degree felony, for allegedly setting five vehicles on fire during the early morning hours of Dec. 20 on Woodland Avenue, Pershing Street and East State Street in Salem. His trial in that case remains set for Oct. 14, with a status hearing set for Sept. 26.
Also served with secret indictments were:
¯ Anthony Mehno, 42, of 1750 Merle St., Salem, illegal conveyance of a drug of abuse onto the grounds of a detention facility, a third-degree felony. Documents alleged Mehno brought marijuana onto the grounds of the Columbiana County Jail in Lisbon on Dec. 27, 2007.
¯ Alpino Raneri Jr., 29, of 264 N. Ellsworth Ave., Salem, using a weapon while intoxicated, a first-degree misdemeanor, and improperly handling a firearm in a motor vehicle, a fourth-degree felony. Documents alleged Raneri had a firearm in his vehicle during a traffic stop on April 14 while he was allegedly under the influence of alcohol or drugs.
¯ William Merritt, 40, of 2332 Dresden Ave., East Liverpool, two counts each of receiving stolen property and forgery, both fifth-degree felonies. Documents alleged Merritt forged two stolen checks on the account of Kenneth Johnson on May 19.
¯ Ronald Davie, 26, of 47496 Calcutta Smith-Ferry Road, East Liverpool, domestic violence, a first-degree misdemeanor. Documents alleged that Davie attempted to cause physical harm to a woman he knows on April 24.


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Easy to Make Pita Pizza Recipe
Pita Pizza is so simple to make. This video shows you how to serve up Pita Pizzas in just minutes. Load your pizza up with any toppings: tomatoes, peppers, onions, spinach, kale, roasted potatoes, goat cheese, feta, artichoke hearts, fresh mozzarella, or Parmesan cheese. Once you finish building up your pita pizza, bake at 350 degrees until cheese is melted, then serve hot.
Makes: 4 pizzas
4 whole wheat pita breads
1/2 red onion, diced
1 yellow or green pepper, diced
2 tomatoes, diced
1 cup freshly grated Parmesan cheese (you can use up to 1/4 cup per pizza, no more than that!)
Pizza sauce


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Walmart proposes supermarket, discount store for New Berlin
Walmart is proposing a combined supermarket and discount store for 16 acres in New Berlin, near the southeast corner of S. Moorland Road and W. Greenfield Ave.
The 150,000-square-foot store would be built at 15205-15375 W. Greenfield Ave., a mostly vacant site that now includes the Charcoal Grill restaurant, according to documents filed with the city's Department of Community Development. That building would be razed, according to the project's site plan. »Read Full Blog Post(35)
Low-quality stocks continue to provide strong returns
For more than three years, investors have loved nothing better than junk.
Stocks of companies with excessive debt, rotten balance sheets and unstable earnings have more often than not been the types Wall Street has loved. »Read Full Article