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President Barack Obama said the U.S.-led forces must "focus on finishing the job" in Afghanistan after what he said appeared to have been a successful election in the country, Reuters reported.
Millions of Afghans went to the polls on Thursday, defying Taliban threats of violence and sporadic attacks to choose a president in the midst of a worsening war.
"We had what appears to be a successful election in Afghanistan, despite the Taliban's efforts to disrupt it," Obama said from the White House. "We have to focus on finishing the job in Afghanistan but it is going to take some time."
The election was a test for Obama's new strategy aimed at reversing Taliban gains. U.S. combat casualties have risen amid a U.S. troop buildup and opinion polls have shown weakening American backing for the war.
Support for the Afghan campaign among some NATO allies is also on the wane and the German government scrambled to quash a public debate about pulling German troops out of Afghanistan that has grown louder amid the surge in violence.
The White House said Afghans had turned out to vote in large numbers despite threats of violence and U.S. policy in the eight-year-old war would not change.
Preliminary results are not due for two weeks, although polling stations could begin to report sooner.
The Afghan government said nine civilians and 14 members of the security forces were killed in 135 incidents countrywide on polling day.
Pre-election polls showed Karzai, in power since 2001, was likely to win but not by enough to avoid a run-off against his main challenger, his former foreign minister Abdullah Abdullah, who ran a surprisingly energetic campaign.
If Karzai fails to win more than 50 percent of the vote he will face a run-off in October, most likely against Abdullah.
The election is in large measure a referendum on Karzai, a master coalition builder who is personally liked by most Afghans but also widely blamed for running a government that is corrupt, ineffective and entirely dependent on international aid.
The president relied for votes on the endorsements of many of the country's notorious former militia chiefs, raising alarm among his Western backers that the cost of a victory in the election could be a return of warlords to power.
President Barack Obama said the U.S.-led forces must "focus on finishing the job" in Afghanistan after what he said appeared to have been a successful election in the country, Reuters reported.
- TURKEYCHP leader urges gov't not to turn post-coup probe into 'witch hunt'
- TURKEYUS offered to help on Gülen's extradition, Turkish FM confirms
- EUROPENo isolationist path for Britain, Johnson insists
- TURKEYSyrian fighters seize half of Manbij from Islamic State
- TURKEYFlights as usual after failed coup attempt, Turkish Airlines chairman says


text:
Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy
The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2007 by NeurogesX.
Recruitment status was Active, not recruiting
Recruitment status was Active, not recruiting
Information provided by:
ClinicalTrials.gov Identifier:
First received: May 21, 2003
Last updated: September 12, 2007
Last verified: September 2007
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is ongoing, but not recruiting participants.
|Estimated Study Completion Date:
|No date given
|Estimated Primary Completion Date:
|No date given

subset: commoncrawl


text:
This Nokia Developer Wiki article explains how the Namedays application is made for the Windows Phone 7. It shows how to load XML data from the server side and bind data to UI. It also illustrates how to localize the application for different languages and how to use Scheduled Task Agent to update application.
You can read the whole story and load the source codes Nokia Developer Wiki.


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Superfeet GREEN Insoles
Product Information:
Maximum support and shock absorption make the Superfeet® GREEN insoles your go-to pair of inserts for your shoes. A high-profile insole, the Superfeet® GREEN comes with a deep heel cup for unrivaled support and shock absorption. The BIOMECHANICAL SHAPE adds stability while improving power and control. To keep your feet fresh, the Superfeet® GREEN insoles come with ODOR CONTORL COATING while HIGH-DENSITY FOAM LAYER ensures comfort.
Click here to learn more about Superfeet Insoles Fit Profiles and Volume
- High-profile insole with a shapes that boosts a wide, deep heel cup for unbeatable support
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- Vegan, free of latex, nickel sulfate, formaldehyde and preservatives
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- Shoe Size: B = Kids' 2.5-4, Women's 4.5-6
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- Shoe Size: G = Men's 13.5-15
- Shoe Size: H = Men's 15.5-17
Country of Origin: South KoreaWeb ID: 4240700
Customer Reviews:
Rated 4.5 out of 5�by 290 reviewers.
Rated 5 out of 5�by Lynn25 Great product worth the price My son said these are the best insoles he has had! Very supportive and comfortable. He has an issue playing sports due having an issue with flat feet, the Superfeet Green Insoles have relieved his discomfort. September 20, 2016
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Rated 4 out of 5�by Davey Superfeet green insoles These insoles have made some difference on my feet . They are not as sore at the end of the day but its not a cure all for sore feet. August 23, 2016
Rated 4 out of 5�by MargeSimpson2016 relief at last these have truly helped my plantar fascitis from getting extreme. August 19, 2016
Rated 5 out of 5�by Sheri47 very good support just what i needed I just had foot surgery and the sales people recommended these for the shoes I bought and they were right worked perfectly. July 26, 2016
Rated 5 out of 5�by EliXC great for shin split treatment and prevention. This is my sons 4th pair. He runs 20mi/wk wouldn't buy XC shoes without these. Shin splits went away within a week during 1st year of XC. Buy new shoes with new Superfeet every season. July 19, 2016
Rated 5 out of 5�by NoneoftheAbove Works as good as a prescription orthotic It turns out our son has reached the age where his pronation has started causing him pain. Believe it or not his pediatrician recommended these rather than going to a podiatrist and getting a prescription orthotic. I have a prescription orthotic which, like glasses, cost hundred dollars after insurance. For $41 this was worth it. June 28, 2016
Rated 5 out of 5�by MamaMia Super Feet are Super Comfy! Very comfortable. I need custom orthotics in my shoes. Since custom orthotics are very expensive, my orthopedic surgeon recommended SuperFeet. Greatest purchase I have made! June 22, 2016
Rated 5 out of 5�by MovinSusan Great arch support! This was my first Superfeet purchase. It took 2 days to get used to them. At first, my feet were more sore and fatigued. Luckily, I was on vacation and made sure to rest my feet the next day. After 1 day of rest, I began wearing them again. They worked perfectly! Before Superfeet my arch was being stretched because it was not supported. Now, I no longer have any problems with my feet. I use these inserts in my running shoes and casual sneakers. May 5, 2016


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Shade Netting with Hoops
This item is currently not available.
Additional Information
All-in-One Shade Netting Tunnel is Easy to Set Up
- Fast and easy way to shade plants from harsh sun
- Durable fabric shade net provides 50% shade
- Wire hoops are sewn into netting; sets up in minutes
With sewn-in, galvanized steel hoops that make installation a breeze, this tunnel is an easy way to provide shade for new transplants and cool-season crops. Just position the tunnel over a row of vulnerable plants for nearly instant protection from intense sunlight. Polyethylene fabric provides 50% shade. Slide fabric up the hoops to tend and harvest. Hemmed edges with drawstring closures at ends. Reusable; folds flat for easy off-season storage.
Product Details
- Polyethylene netting, galvanized steel hoops
- Approx. 9' 8" L x 25" W x 20" H installed
- Imported fabric
There are no special shipping restrictions or charges associated with this item. For detailed information about our delivery methods and charges, click here.
We're proud of the fact that this item is shipped to you directly from our warehouse in Vermont, by one of our 250 employee-owners. In-stock items are packed with care and shipped within the next business day to ensure prompt delivery to your home and garden!


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IACP South American Executive Public Safety Seminar: Fortaleza, Brazil
By Paul Santiago, Director, International Activities and Support Services, IACP
n June 18, the governor of the Brazilian state of Ceara, Lucio Gonçalo de Alcantara, opened the IACP's sixth major South American event hosted in Brazil in the past six years. The IACP South American Executive Public Safety Seminar was organized by the secretary of public safety for the state of Ceara, headed by General Theo Espindola Basto. IACP President Mary Ann Viverette was represented by one of the IACP's executive board members, Mark Whitman, chairman of the IACP Division of State Associations of Chiefs of Police and commissioner of the police department in York, Pennsylvania. Joining Governor Lucio Alcantara on the dais was the Brazilian national secretary of public safety from the Ministry of Justice, Luiz Fernando Correa, the most senior federal government representative, whose support was instrumental to the success of the seminar.
Under the auspices of the IACP, the seminar featured simultaneous meetings by major Brazilian law enforcement councils, such as the Council of State Secretaries of Public Safety, the Council of State Military Police and Fire Brigade Commanders, the Council of Civil Police Chiefs, the Federal Highway Police Regional Commanders, and the Council of State Forensic Investigators, State Intelligence Coordinators and State Public Safety IT Coordinators. The public safety seminar is perhaps the only event in Brazil that draws together so many Brazilian law enforcement executives under one roof. This concept began three years ago in Belo Horizonte under the leadership or the IACP's world regional chair for South America, General Athos Costa de Faria, secretary of public safety for the Federal District of Brazil. He has been the IACP's lead contact in the South America for four years.
At the seminar, National Secretary for Public Safety Luis Fernando Correa talked about the security plan for the Pan American Games, to be held in Rio de Janeiro next year, a plan that, according to Correa, demonstrates solidarity among the various police agencies involved. Detective Superintendent Thomas Ekman from Sweden gave a superb presentation on the current state of trafficking in women and children in Sweden and in Europe in general. Ekman returns to Sweden in a prominent new position on the Swedish Police Board, where his expertise will be put to use on a national basis.
Mr. Meir Gershuni, director of the Foreign Service Security Bureau in the Israeli Ministry of Foreign Affairs, provided a presentation called "Main Threats and Security Principles: The Israeli Perspective." Mr. Gershuni's presentation included an interesting analysis of terrorist methods of attack and countermeasures developed by the Israeli Security Agency and the Ministry of Foreign Affairs Security Bureau, through research and development. Dr. Peter Collins, forensic psychiatrist in the Behavioral Science Section of the Ontario Provincial Police, presented on behavioral sciences in policing, concentrating on criminal profiling, threat assessment, computerized linkage analysis, geographic profiling, and forensic psychiatry. Mr. Darci Escobar Rodriguez, with the counter drug unit of the Peruvian National Police, spoke about drug-related kidnappings and police countermeasures.
The exhibition at the seminar featured 67 exhibitors, including platinum-level sponsors Engesig, Motorola, Rontan, and Volkswagen, and gold-level sponsors Agora, EADS, Helibras, and Tyco Electronics M/A-COM. The exhibition took place at the Ceara Convention Center and was an integral part of the IACP South American Executive Public Safety Seminar. Assisting the host with organization and promotion was longtime IACP partner FAGGA EVENTOS, an events planning firm whose president, Arthur Repsold, was recently named GL events president for Brazil. The firm will oversee of the largest convention center in South America, Riocentro, in Rio de Janeiro, among others.
It seems that delegates, exhibitors, the seminar hosts, and all involved were exceptionally pleased with the outcome of the seminar. Attendees came from as far away as Canada, Colombia, Israel, Peru, Portugal, Sweden, and the United States, to mention a few. The exhibition was visited by more than 5,000, of which approximately 2,000 were registered seminar attendees.
This was the first IACP regional event that was almost completely self-sustained without IACP funding. Therefore, special tribute must be paid to the government of Ceara. Governor Lucio Alcantara, who played an exceptional role with his personal engagement and support, helped make the event possible in Ceara. With General Theo Espindola Basto's great leadership, the organizing committee, along with the public safety organizations under his command, performed exceptionally well while at the same time demonstrating great hospitality. To IACP World Regional Office Chair Athos Costa de Faria, our great thanks for his oversight and leadership. Congratulations to all who helped achieve the great success of this seminar. ■
From The Police Chief, vol. 73, no. 10, October 2006. Copyright held by the International Association of Chiefs of Police, 515 North Washington Street, Alexandria, VA 22314 USA.


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I interrupt my series of posts on black conservative voices to bring you the latest on our awesome new Senator from Texas, Ted Cruz. Not only has he introduced a bill to repeal Obamacare, but he sent this letter to gun manufacturers and the banks who deal with them in Chicago encouraging them to move to Texas where we aren't trying to suppress our 2nd Amendment rights. Best part? "We do not accept the notion that government officials should behave as bullies, trying to harass or pressure private companies into enlisting in a political lobbying campaign." Isn't it about time someone called out Democrats for doing this? But maybe the best part is where he calls Rahm Emanuel, "The Godfather." Cruz has hit the ground running in D.C., and I could not be happier about it.
Letter from Senator Ted Cruz to Chicago Mayor Rahm Emanuel, Bank of America, TD Bank Group, Smith & Wes… by


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The ABC's of sun protectionUPDATED 10:11 AM PDT May 05, 2013
Dr. Timothy Rosio gives you some tips on sunscreen protection and other ways to minimize exposure to the sun.
More Video
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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In the October issue of Esquire, Brad Pitt laments of his infant daughter, "Shiloh's got horrible diaper rash, poor thing. Same with Zahara when we picked her up in Ethiopa. … We've tried everything – every cream, every salve, every natural product. We haven't found the magic ointment. Yet."
So on Monday PEOPLE.com asked readers for advice for Pitt and Angelina Jolie – and they came through.
In less than five hours nearly 900 people had responded with remedies ranging from cornstarch to letting Shiloh spend more time au naturel ("good old fresh air works the best"). But the one product they overwhelmingly recommended was Boudreaux's Butt Paste.
"I swear by that stuff!!" Jamie C wrote. Seconded Vita Migues, "When my little boy had diaper rash the pharmacist told me about this, and so did several other mothers. They were right. It's the best out there. I buy it for baby shower gifts now."
So what is Boudreaux's Butt Paste? It's a mixture of zinc oxide, castor oil, mineral oil and Peruvian balsam invented by Covington, La., pharmacist George Boudreaux in the late '70s – and now sold nationwide at stores including Wal-Mart and Walgreen's.
Boudreaux is delighted that his product has been so highly recommended to Pitt and Jolie. "Give me their address and we'll take care of it!" he says. "If they use our product, I guarantee you it'll work."
This isn't Butt Paste's first rub with celebrity – according to Boudreaux, the ointment, which also helps athletes keep chafing at bay, has been used by Lance Armstrong, Shaquille O'Neal and Peyton Manning. And Boudreaux says he even sent a case to Donald Trump when little Barron was born.
Brad's Diaper Drama: Readers to the Rash-cue
Cheryl Gerber/Splash News


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Why not shave Eddy Curry's head, put an orange head band and a really tight girdle on him,send him to Houston and trick the Rockets into thinking that he is Al Harrington?
The Knicks are going nowhere without some help. I'd make him the PG or a point forward and let him run the offense. Jeffries has to be the other player in this scenario and maybe a draft pick to the Wiz. Cap space has to be the top priority for Walsh to pull the trigger on this trade.
[Only registered and activated users can see links. ]
The Houston Rockets are in the discussion stages of a complicated, three-team trade that would send Tracy McGrady(notes) to the New York Knicks, sources told Yahoo! Sports.
The centerpieces of the trade would include the Washington Wizards shipping forward Caron Butler(notes) and center Brendan Haywood(notes) to the Rockets. The Knicks would send Al Harrington to the Wizards. For the Wizards part, they would still need another player, as well as a draft pick and cash to make this a workable scenario, sources said.
Other players and contracts would still need to be agreed upon for a deal to come together, but there is a framework to the discussions.
The Rockets have been peddling McGradys expiring contract of $23 million since exiling him in late December.
Why not shave Eddy Curry's head, put an orange head band and a really tight girdle on him,send him to Houston and trick the Rockets into thinking that he is Al Harrington?
New York Knicks = An organization more useless than a bag of rocks painted in orange and blue. The most over-paid collection of talent ever assembled on an NBA floor. They could only be coached worse by a dead Rich Kotite.
I do not get what this deal would do for us now! We are 5 1/2 games out of the playoffs, unless we trade Jefferies in this deal, what is the point?
Tracy McGrady will give us the same exact thing as Al Harrington, while bumping either Danillo or Wilson out of the starting 5 -unless T-Mac comes of the bench-.
Its not like we want his bird rights, because frankly we cant afford them! T Mac will come to NY trying to earn himself a Max Contract this summer and the Knicks will suffer as a result
If The Knicks really want him, let him sit out the rest of this season and snag him for a one year 4-6 million deal this summer......I dont think he will get a better offer having only played like 10 games in the past year!
"I'd Rather Melo shoot with 3 men on him than Jefferies shotting wide open"
-Jeff Van Gundy
David Lee + Eddy Curry -> McGrady
David Lee + Harrington + Jeffries -> McGrady
Lee, Harrington, Mcgrady are free agents at the end of this year so all of them have equal value to us. If this is the best way to get rid of Curry or Jeffries without giving up anything of value in 2010/2011 season, we have to jump on it.
This trade would work and Dallas would probably go for it. They are desperate to make a change right now.
Let's face it. Lee is not going to be here next year. We might as well get something in return.
am i the only one on this board who still thinks curry will come back and be dominant next year???
I am pretty sure you are good sir!
Look Jermaine O'neal was a much better player than Curry and has a much stronger work ethic and he has not returned to form and he has 1. missed fewer games than Curry over the past two seasons and 2. he is playing with a Mega Star who would push him to be his best.....point being if he cant do it, no way Curry can!
Sorry to burst your bubble
Last edited by New New York; Feb 10, 2010 at 10:19.
"I'd Rather Melo shoot with 3 men on him than Jefferies shotting wide open"
-Jeff Van Gundy
people said the same type of thing about Z-Bo... now he's an all star.
Harrington makes 10 million and Mcgrady makes 23 mil so hows that going to work??
"The Knicks are back" - Amare
NO other TEAM in NBA right now is not in a horrible position as the NY Knicks. We are in a bad shape not just roster wise and cap space problems, but also as an institution we are in bad shape.
JAMES ****IN Dolan needs to sell this team before he ****s it up. James Dolan is the owner of NY KNICKS and MSG, while he doesnt even care about the team, only the money. I bet you Dolan doesnt even know the rules of basketball. We need an owner that loves this game and will love our team and who loves NYC. Like Mark Cuban?? U know someone like that.
U know Dolan is gotta be strict for the team to be better. the players and the coaching staff gotta be scared of losing their jobs if they dont do their jobs. Here in NY they are not scared they just have fun.
T-Mac gives us a little more than Harrington since he can play PG, SG or SF. Gallo needs to come off the bench right now until he gets his game together and Chandler will benefit from being inserted into his natural SF spot.
T-Mac has a lot to prove and I see him opening a lot of eyes PLUS if he's back to form then we can re-sign him to a smaller contract and pair him with a max FA. We're not getting 2 max FAs so this is a potentially good scenerio. If healthy (which I believe he now is) he has a few good years left.
Real Talk


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on October 7, 2012 - 12:01 AM
President isn't fit to lead our country
President Obama shows passion on the golf course, basketball and beach. We see him on late night talk shows, we see his constant campaigning. He delivered a flat, obligatory tribute to the murdered Americans. What probably was on his mind was a rush to take our Air Force One to Las Vegas for a fund-raiser. If only he would show as much outrage at the terrorists that he shows against the tea party and Fox News. What makes a growing number of Americans angry is the lack of anger this president exhibits toward the threats we face abroad. We want a leader, not a celebrity who puts our self-preservation second to his.
The president can't bring himself to say that the protesters hate us and our freedom. Why? Under principles of international law, attacks on diplomats can be considered an act of war.
Obama came to office believing that America has a lot to apologize for. And he continues to apologize to radical terrorists. Does anyone remember Hillary Clinton's words when she was running against Obama? She described him as "inexperienced" and not ready to be president.
John Orlowski


text:
Thank you for taking the time to report this. We've audited this
sender; they are a social network, where users can communicate within a
network or users inviting friends to join a forum. The sender also
implemented Captcha as part of the registration. We are working to find
out more of the how they've acquired a spamtrap address. We will provide
an update as we conclude this investigation.
Kind regards,
Eloise Carlton
On Fri, May 2, 2008 at 7:29 AM, Matus UHLAR - fantomas
> On 02.05.08 19:11, ram wrote:
>> I am getting spams on my spamtraps which are coming with
>> Where do I report these
> try searching the habeas website...
> --
> Matus UHLAR - fantomas, email@example.com ; http://www.fantomas.sk/
> Warning: I wish NOT to receive e-mail advertising to this address.
> Varovanie: na tuto adresu chcem NEDOSTAVAT akukolvek reklamnu postu.
> Fighting for peace is like ****ing for virginity...


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Hey everyone, I'm currently living it up in China and will be for another week or so, poking my head in from time to time to make sure things are okay when I have some free time. The trip has been great so far, we've been able to see a lot of the sights in the Shanghai, Huangshan and neighboring regions and now we're in the midst of buying a lot of goodies to bring back to the states, many of which are wedding related. (yikes) There's a tremendous amount of construction and growth in the city of Shanghai, much more so than one could picture without actually seeing pictures or coming here. The disparity in wealth is staggering, even within the city itself, you have people driving million dollars cars able to get out and eat dinner for 8 for under $25 USD (and it's phenomenal food too). Want a tailored suit? $75. Tailored shirts? $12. Silk ties? $1.50. It's stunning.
The city itself is amazing to look at as well, it's like they took pictures out of what Asimov would've envisioned for the future and built it, lots of glass buildings with unique and quite imaginative designs. Perhaps pictures will be up in the future, until then, feast on these domestic treats:
- JLP discusses his disdain for both payday loans [3] and the implication that borrowers are victims and not willing participants. I totally agree.
- MBH shares his local weekend yard sale loot haul [4].
- FMF writes about eight work perks [5] you probably wished you had. A break on the mortgage sounds pretty darned good!
- Nickel has a great tip on how Vanguard will waive account minimum fees [6] if you agree to accept electronic documents, a win for you, a win for Vanguard, and a win for planet Earth!
- Flexo writes about the fifth couple living on $47k [7].
- Did you know that if you have more than $25,000 saved for retirement [8] you're ahead of the curve? It's seems remarkably low to me, remarkable and very disconcerting.
- Someone bought a Wii [9]! Consume consume consume!
- Golbguru has a post about how much it costs to repair damage from low speed hits to the bumper [10] (and the lights, etc. that the bumper is meant to protect), something that I think I've heard on NPR before but never saw in writing before. Low speed meant 3 mph for corner hits and 6 mph for head on… max damage was to the Maxima at over 9 grand. A good read.
- I've been trying to keep up on Jeremy's series on 24 signs you could be in financial trouble and the second to last one, numero 23, is a good one – lack of a well-defined goal and a plan to reach them [11]. Incidentally, you should read the other 22 he's put up already because more than a few of those are gems as well.
- Do you have a Bank of America account and ATM card? You can get free admission into 85 museums during the month of May! Details [12].


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Last night, the Dubois County Council approved an appropriation of $30,000 for the Highway Department to begin the process of designing a second access road to the county park.
The idea of a second access road for the park is something that has been thrown around for months amid concerns of emergency vehicles having difficulty entering the park in the event of an emergency during events such as the 4-H fair with just one access road, which currently enters the park off of State Road 162.
The proposed road would cost the county $375,000 including the design cost and it would branch off of an unnamed gravel road west of the park to the east of County Road 50 East and just to the north of County Road 450 South.
Dubois County Park Board President Jason Schmitt says the appropriation for design is a good first step:
Much of the debate on the new road amongst council members during last night's meeting surrounded whether to make the new road a fully paved road or to make it more of a chip and seal type road, a solution that the council as a whole seemed to have no problem with.
County Council President Greg Kendall says the road will certainly be important in the event of an emergency:
The road would mostly be used in emergency situations. A gate would be installed towards the end of the road near the park and would likely be locked if there are no events going on at the fairgrounds. County Engineer Jason Heinle told the council that residents would have to sign a right-of-way petition before the county could begin any construction of a new road.
Also last night, the county council approved a total appropriation of $75,200 for the Sheriff's Department for roof work on the county jail. That figure takes into account the cost of a brand new rhino-liner to put over the current roof, which Kendall says would save the county a significant amount of money versus replacing the roof, as well as the cost of repairing recent tornado damage.


text: Lange XT 120 100mm - Men's: The new Lange XT 120 boot delivers the performance of a competition boot with the functionalities needed to enjoy All Mountain/Freeride skiing. Thanks to the Ski/Hike function, the Arch Pad and the extra light liner, the Lange XT 120 is the perfect boot for adventure skiing. Available in 100 mm last.


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Dementor Flashbacks
Forum page
13,885pages on
this wiki
this wiki
Throughout the book, Prisoner of Azkaban, Harry gets small 'flashbacks' from the night of his parent's death when he is near dementors. In which book, and preferably which chapter, does he have a full flashback of their death which begins with Voldemort outside their house in Godric's Hollow on Halloween? —The preceding unsigned comment was added by 184.108.40.206 (talk • contribs).


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Colt Model 1877 Thunderer Handgun
Item # UF100381149
Key Features
Action - Revolver
Action Type - Double Action
Caliber - .41 LC
Barrel Length - 4-1/2"
Weight - 1.4 Lbs.
Our Price $1,399.99
Availability: Sold Out
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Product DescriptionThe Model 1877 was Colt's first attempt at manufacturing a double-action revolver and its early double-action mechanism proved to be both intricate and delicate. Originally called the New Double Action Self-Cocking Central Fire Six Shot Revolver, the Model 1877 was designed by Colt's well-known employee, William Mason, who also designed the famed Single Action Army Model of 1873. The 1877 has a three-position hammer with safety, half-cock, and full cock notches. Other attributes include a cylinder pin mounted through the center of the frame, a loading gate mounted on the frame, and a rod ejector mounted on the barrel. Its signal rear-offset "birds head" grip which gives the revolver a very distinctive look. This 1881-manufactured revolver features a nickel-finished frame, rubber grips, an etched barrel, and fixed sights. Its grips, its metal, and its bore are in good condition.


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Handing off the reins? Or, reigns?
While Prince Charles is set to take a more central role in the life of the British monarchy – stepping in to help his 87-year-old mother, Queen Elizabeth – palace sources strongly deny this means the Queen is preparing to step aside for her son.
She is still planning a full year of engagements, and a visit to Normandy for the anniversary of D-Day landings is not "out of the question," one says.
Still, a key step underway is to merge the press teams of the two households, under the command of Sally Osman, who is Charles's communications secretary.
The step will mean better coordination of schedules and ensure that the message is clearer, insiders believe.
"A number of members of the Royal Family support the Queen in her work, and it's better to coordinate the communications around that to have everyone here working on the same team," a royal source tells PEOPLE.
Still, with Monday's news reports, longtime royal chroniclers find themselves adjusting to what changes may lie ahead.
"It is not a 'job share.' Prince Charles already has a packed diary and can't take on the Queen's role unless he gives up some of his work. This is where William and Harry come in. It is about them taking on some of the work too," says royals author Judy Wade.
Ingrid Seward, editor-in-chief of Majesty magazine points out the red boxes of government papers the Queen has to read each day "take up a massive amount of her day," and Charles can step in and help.
She adds, "It was always the plan to wait until Prince William was settled before making any major changes. Prince Charles has always been insistent his son should have as much family life as possible before taking too many royal duties.
"Combining the two major royal offices makes perfect sense. It is time Prince Charles eased the burden on his 87-year-old mother and she has finally agreed he can do so. Therefore, William and Harry have to do the same for their father."
Charles and Queen's Office Merger Seen as a Royal Hand-Off
Indigo/Getty; Abaca


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Acer Aspire 8942G-434G64BN
Average of 4 scores (from 4 reviews)
Reviews for the Acer Aspire 8942G-434G64BN
Source: T3
The Aspire 8942G proves just how far Acer has come in the last few years, and just how much you can now get for your money.
Single Review, online available, Short, Date: 06/09/2010
Rating: Total score: 80%
Foreign Reviews
Source: PC Games Hardware - 5/10
Comparison, , Length Unknown, Date: 04/01/2010
Rating: Total score: 91% price: 70%
Source: PC Action - 4/10
Comparison, , Length Unknown, Date: 03/01/2010
Rating: Total score: 90% price: 60% performance: 89% features: 91%
Source: TV Movie Multimedia - 4/10
Comparison, , Length Unknown, Date: 03/01/2010
Rating: Total score: 91% price: 80%
ATI Mobility Radeon HD 5650: Middle class DirectX 11 capable graphics card with a power consumption of about 15-20 Watt. Supports Eyevision (up to 6 monitors)
Non demanding games should be playable with these graphics cards.
» Further information can be found in our Comparison of Mobile Graphics Cards and the corresponding Benchmark List.
The Core i5-430M is a middle class dual core CPU that features only 3 MB L3 Cache (compared to the I7-640M) and clocks between 2.26-2.53 GHz (Turbo Mode). Furthermore, VT-d, trusted Execution and AES features are missing in the 430M. Thanks to Hyperthreading, 4 threads can be processed simultaneously. An integrated graphics card (Intel HD Graphics with 500-733 MHz) and a DDR3 memory controller are also included in the package.
» Further information can be found in our Comparison of Mobile Processsors.
This is a very large display size for laptops on a desk without mobile use.» To find out how fine a display is, see our DPI List.
4.6 kg:
This weight is representative for typical laptops with a 14-16 inch display-diagonal.
Acer: Acer Incorporated is a Taiwanese multinational electronics manufacturer. Its product lineup includes desktops and laptops, as well as personal digital assistants (PDAs), servers and storage, displays, peripherals, and e-business services for business, government, education, and home users. Acer is the third largest computer manufacturer in the world (by sales) after HP and Dell Inc (2007). The company owns the largest franchised computer retail chain in Taipei, Taiwan. Originally named Multitech, it was founded in 1976. Gateway and Packard Bell are economically connected with Acer. Market share regarding sales of personal computers in 2007 (market research IDC): HP 18.9 %, Dell 16.4 %, Acer 9.9 %, Lenovo 7.5 %, Apple 5.7 %
88%: This is a good rating above average. Nevertheless you should not forget, that 10-15% of all notebook-models get a better rating.
» Further information can be found in our Notebook Purchase Guide.


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Top Definition
Stemming from the greek word for cock "kavli", a kavlilier is a gentleman trained in penis and mansmanship.
A classy homosexual.
A classy homosexual.
Tim Gunn is such a kavlilier, he's so classy and homosexual!
Beküldő: lewddinosaur 2011. június 10.
Trending Now
Can you define these popular missing words?


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2nd Amendment
December 25, 2002, 02:42 PM
96.97 posts per day, #5 on the top 10 list, over 100 posts total and you registered the same time I did! Did you have a lot of pent up verbiage you didn't want to waste on TFL in its' declining days or is the conversation here just that stimulating?! :D ;) :p


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Just wondering...have any medical students found they are able to manage a part time job or a holiday job during their preclinical years?
Also, what types of jobs? As a med student are there any opportunities out there to gain some work experience for later?
(n.b. I've worked in a clothes shop, care home and now HCA in hospital so trying tp think of other possible part time or holiday jobs)
Possible to have a part-time job during your degree?
|Posted on
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Yep, no dramas.
Gaining 'work experience' is called clinical years.
Sure My sis is a medic and works for a catering company who basically ask her to do hospitality work whenever it comes up, and she chooses whether she's too busy to take it or not
I worked term time and holidays for the first 2 and a bit years. just pub work but is nice to get out the medic-ness for some time each week. No way would I want to be a phleb/nurse etc as part time job while at uni!
i work. i worked in a shop a lot of last year. this year i have much more flexible stuff on to do with mentoring, widening participation that sort of thing with the university and aim higher. that pays much better
i also worked over the summer. if you get a job you can come back to at home keep hold of it and you can work other holidays, otherwise i guess after first year if you wanted you could stay in your uni house and work from there.
I DJ and the TA Brings me a fair amount of money in!
(Original post by digitalis)
Brings me a fair amount of money in!
Sorry for lack of my CDs the other night mate.
Hmm I actually get expelled if I get a term time job... I couldnt manage one anyway because my time is so flexible. One day I might have loads of free time, the next Ill have none and this changes weekly. I do some paid work in the holidays and the like to make sure Ive got enough money to live for the next year but thats about it!
Aye - I've partaken in paid work since year 1... Often ya gotta...
I've done mainly medical secretarial work in the summer holidays for the first 3 years but now I don't really have time. I earn a few quid here and there doing things like research experiments and the student transplant rota, but don't have a proper job. I guess I'd have time for a weekend thing if I didn't have a boyfriend in London...
Why can't you carry on the HCA work? I hear a lot of hospitals are gagging for them.
Assuming you're not talking about DJing.
Sorry for lack of my CDs the other night mate.
No worries mate, punters didn't seem to mind...except one bloke who got extremely angry when I didn't have "we are the champions"
(Original post by digitalis)
DJing=beer money at best, tube fare at worst
No worries mate, punters didn't seem to mind...except one bloke who got extremely angry when I didn't have "we are the champions"
(Original post by Tyraell)
Why can't you carry on the HCA work? I hear a lot of hospitals are gagging for them.
You can do HCA work, over the holidays and bank weekends during term.
My recommendation would be to do something non-clinical, there's lots to see and do in the real world before getting stuck in medicine.
^^^Agreed. You do need to seperate your academic and professional life as a student I've always found...
Medicine as a course is demanding from what I can gather.........
At the same time 5 years and wanting to have some fun...especially if u are in london means that perhaps a weekend job is a good idea...
wouldit be possible or is there too much work
I have spoken to my sis about it b4, she has some med students living with her. She says that they dont have part time jobs but jobs during the holidays and use that money during the term. Maybe med students can have part time jobs but I would think only one day per week so either a sat or sun. I think that should be ok if u can balance work time and school time. Hopefully thats a bit of help.
Weekend or evening jobs are no drama, you just have to balance it with the loss of opportunities - you might not be able to commit all the time you want to clubs, socs or ents.


text:
On Wed, 18 Jun 2008 23:27:02 +0100, Cork Soaker wrote:
> Has anyone managed to get Cinerella installed on an Ubuntu system? It's a
> bloody nightmare trying to find a working respository, and trying to build
> it fails immediately!
> n:/tmp/cinelerra-2.1# ./configure
> ./configure: 11: arch: not found
> ./configure: 24: arch: not found
> [: 24: i686: unexpected operator
> [: 31: ==: unexpected operator
> ./configure: 47: Syntax error: Bad fd number
> Help! :-(
Try Open Movie Editor, I always had problems with Cinelerra. But if you
must find the 2.1CV source. It built ok for me however i don't know what
you are lacking. Also if you get it built you need to run it as SU. If I
don't run it that way it freezes immediately.


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Fashion Lighting 1, 2, 3
Lesson 1: Introductionwith Lindsay Adler
No course objectives yet
No materials available for this course
Lindsay Adler
Lindsay Adler is a professional portrait and fashion photographer based in New York. For the past 10 years she has owned and operated a portrait, fashion, and wedding studio distinguished by its 'fashion flair' approach to imagery. As a New York fashion photographer, she has written editorials that have appeared in dozens of publications internationally. She regularly contributes to a variety of major photo publications, including "Professional Photographer," "Rangefinder Magazine," "Popular Photography," and more.In May 2010 Adler published her first book, "The Linked Photographers' Guide to Online Marketing and Social Media." In February 2011 she published her second book, "Fashion Flair for Portrait and Wedding Photography."Adler, a Sigma Pro, is sponsored by a variety of major photography companies and spends a lot of her time traveling to teach workshops and at major conferences. You can find her as a platform speaker at events like WPPI, PhotoPlus, NECCC, PSA, and many more. She teaches thousands of photographers annually on topics ranging from retouching to fashion techniques to studio lighting.Though only in her mid-twenties, her career and photography have received much acclaim and she has already become a respected name in the business.


text:
by: iRobot
Product Code: S390020
Condition: Brand New
Availability: In Stock
$ 499.99 $ 599.99
Scooba 390 Core Technologies:
Thorough Cleaning:
Package Dimensions: 21.3 x 17 x 5.2 inches
Package Weight: 13 lbs.
Robot Dimensions: 14.8 inches in diameter, 3.6 inches in height
Robot Weight: 8.6 lbs.
*When used as directed, laboratory testing results indicate removal of Escherichia coli and Staphylococcus aureus bacteria after two passes of the Scooba floor washing robot. Individual results may vary.
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AimToFind.com is an Authorized Dealer. This means when you shop at AimToFind.com, you get:


text:
WAYNE, N.J. -- Grand Union Co. here said it will not make a $36 million interest payment that is due next Monday. The chain said it will instead use its 30-day grace period to negotiate a capital restructuring with its bondholders and try to obtain a waiver that will keep the chain from defaulting on its bank loans. If no restructuring is agreed upon by the end of the 30-day grace period, Grand Union said it will be in default under the indenture governing its 12% senior notes due Sept. 1, ...
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Tixdaq is the UK's leading ticket search engine Liga Perdana Malaysia tickets. We search all the major ticket vendors in the UK to bring you the widest choice of Liga Perdana Malaysia tickets from both the primary and secondary ticket markets. Simply search for the artist, theatrical performance, stand-up comic or sports event or browse the full listings on any category page to find the right ticket for you.
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All Blacks star Dan Carter expects to face England in Twickenham Autumn International
All Blacks fly half Dan Carter expects to face England at Twickenham.
Gavin Henson to remain at Toulon
Gavin Henson is set to remain at Toulon after the French club lifted his suspension following a disciplinary process.
Newport Gwent Dragons interested in Gavin Henson
Newport Gwent Dragons have admitted they would be interested in bringing Gavin Henson to their club, should he be released by Toulon.
Gavin Henson faces anxious wait after suspension
Gavin Henson will discover the outcome of Toulon's disciplinary process on Friday after meeting with club officials today.
Sebastian Chabal apologises after criticising referee
Sebastian Chabal has apologised after being banned for his comments criticising referees.
Brian O'Driscoll turns down royal wedding invite
Brian O'Driscoll is set to dodge his invitation to the royal wedding in order to prepare for Saturday's European Cup semi-final.
England need to improve for World Cup, says Simon Shaw
England's Simon Shaw has stated that England must build on their Six Nations campaign if they are to taste success as the Rugby World Cup in New Zealand this year.
Ross Young appointed boss for 2015 Rugby World Cup
England Rugby Football Union have hired Ross Young to deliver the World Cup in 2015.
Saracens vs London Wasps tickets available for Boxing Day clash
Saracens will take on London Wasps at Wembley Stadium on Boxing Day.
Wales have opportunity to prove doubters wrong with victory over Springboks
Wales have an excellent chance to reverse an eleven year losing record against South Africa. Compare and buy Wales Rugby tickets online.
Rugby World Cup Ticket Prices Revealed
Adult ticket prices will range from NZ$30 for first round matches, up to between NZ$390 and NZ$1250 for a ticket for the final. The organisers of the 2011 Rugby World Cup have...
England receive IRB rankings boost
England and Ireland climb up the IRB rankings while Wales are the big losers. Compare and buy rugby union tickets online now.
Springboks and All Blacks headline Autumn Internationals final weekend
With France playing New Zealand and Ireland taking on South Africa the last weekend of Autumn internationals promises to be full of drama. Compare and buy rugby union tickets...
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The Barbarians have announced the squad that will take on the All Blacks at Twickenham on Dcember 5th. Compare and buy Barbarians tickets online now.
Wales Relishing Chance to Thump Aussies
After Scotland held out to pull off a shocking defeat of the Australian Rugby team over the weekend, Wales are in no doubt that they have to follow in the footsteps of their...
Saracens stun subdued Springboks
South Africa slumped to another shock defeat when they were beaten 24-23 by Saracens thanks to a last minute drop goal from one of their fellow countrymen.
Saracens Wembley date with the World Champions
Sarries host a prestige friendly against South Africa and give their loyal fans a chance to see the best team in the world.
Autumn International rugby tickets selling like hot cakes
The arrival of the southern hemisphere giants in Europe has caused a stampede for tickets. International rugby tickets are available to compare and buy online.
England Seek Revenge
Rugby fans are in for another treat as we look ahead to an action packed weekend. England, Wales, Scotland and Ireland all play this coming Saturday in what will no doubt be...
Six Nations Tickets For All 2013 Matches Now On Sale
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Intraocular Lens Implants (IOLs)
Premium intraocular lenses (IOLs) are permanent implants designed to function just like the eye's natural crystalline lens, which is extracted during cataract surgery. By implanting IOLs, our Ophthalmic Consultants of Connecticut surgeons help cataract patients regain clear vision after surgery. One of many advantages associated with premium IOLs is that postoperative cataract surgery patients are able to see better at multiple distances, often greatly reducing their need for corrective eyewear.
OCC offers cataract surgery patients a wide range of premium IOLs, including:
The type of IOL your OCC cataract surgeon will recommend for you will greatly depend on your unique circumstances, vision correction needs and lifestyle. Please read the paragraphs below to learn more about your IOL options.
About AcrySof ReSTOR IOL
The AcrySof ReSTOR is a multifocal IOL designed to give postoperative cataract surgery patients a full range of vision after surgery. This means many patients are able to see near, far and everything in between without eyeglasses. In addition, the unique, patented optic design of the ReSTOR lens, which combines the strengths of apodized diffractive and refractive technologies, similar to a telescope, also corrects presbyopia, the age-related loss of reading vision.
In an independent clinical study on AcrySof ReSTOR, four out of five patients who received this IOL reported never having to wear eyeglasses. Nearly 94 percent were so thrilled with the quality of their near vision that they would have the ReSTOR IOL implanted again.
If your goal after cataract surgery is to see clearly at most distances without spectacles, the ReSTOR lens may be an excellent option for you.
About AcrySof Toric IOL
The AcrySof Toric IOL, which is manufactured by Alcon, also the maker of the ReSTOR IOL, is an astigmatism-correcting lens. AcrySof Toric provides clear postoperative vision by correcting astigmatism, distorted vision due to an irregular shape of the cornea. With AcrySof Toric, our cataract surgery patients with pre-existing astigmatism are able to achieve excellent distance vision without the need for glasses.
However, it is important to note that AcrySof Toric patients who also suffer from farsightedness or presbyopia may have to wear spectacles for improved near vision.
About Tecnis Multifocal IOL
The Tecnis Multifocal IOL is similar to the ReSTOR lens in that is provides multifocal correction, meaning patients with this IOL are able to achieve clear vision at most distances. However, the Tecnis IOL uses a different refractive system to focus light into the retina, thereby providing improved vision at any distance and in any light condition, including extremely low light environments. Tecnis Multifocal can also be used to correct presbyopia.
Clinical trials that led to FDA approval of the Tecnis Multifocal lens in 2009 demonstrated that 93 percent of patients who received this IOL in each eye were able to achieve 20/25 or better distance vision and 20/32 or better near vision.
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The Crystalens accommodating IOL is a monofocal lens that is designed to correct presbyopia as well as nearsightedness and farsightedness, allowing our cataract surgery patients to treat a range of vision errors with just one lens implant. Unlike any other type of IOL approved by the FDA, the Crystalens has a uniquely designed hinge that allows it to move back and forth to accommodate the eye's focusing efforts. In other words, this IOL uses the eye's natural focusing ability to provide sharp vision at multiple distances. Crystalens is an excellent IOL for our cataract surgery patients.
In clinical studies, more than 80 percent of Crystalens patients were able to obtain 20/20 or better near vision within six months after surgery.
For more information on premium IOLs and cataract surgery, please contact us today to schedule your consultation appointment.


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Metal Shop - February 26th, 2011 - Hour 2
57:09 minutes Metal Shop - February 26th, 2011 - Hour 2
In tonight's segment From The Vault, we payed homage to Extreme Noise Terror's Phil Vane, who unfortunately passed away this week. You just joined the greatest band ever, IN HELL! \m/ We gave away tickets to see TNA wrestling, and Kevin told his backyard wrestling story, as well as White Chapel/Acacia Strain tickets! The end of this hour also features a debut track from the new Moonsorrow record.
| More


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on July 9, 2013 - 4:55 PM
Mr. and Mrs. William A. O'Sullivan of Buffalo celebrated their 50th wedding anniversary with a family gathering. Mr. O'Sullivan and Patricia Moran were married June 8, 1963, in Nativity of the Blessed Virgin Mary Catholic Church, Buffalo. He is a retired correctional officer for New York State with 21 years of service; she retired from Buffalo Psychiatric Center with 38 years of service. They have five children and nine grandchildren.


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Top Definition
The morning after leaving an abundance of videos on friends's facebook walls. You are usually embarrassed or exhausted from trying to entertain all of facebook's newsfeed.
"Oh my god, I have a video hangover. We left too many videos on Sally's wall last night."
بواسطة warislamepeaceistame17 أكتوبر/تشرين الأوّل 4, 2009
Trending Now
Can you define these popular missing words?


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Medicaid savings — in lives
After our governor announced that Texas would not expand Medicaid next year under the new health care law, several commentators pointed out that this decision could be very expensive. But the real cost of not expanding Medicaid is in human lives.
Just how much the human cost could be was shown by a recent study published in the New England Journal of Medicine. The researchers had looked at several states that had recently expanded their Medicaid programs in a manner similar to that called for in the new federal health care law. The result was that providing Medicaid coverage saved the life of one person out of every 176 people covered, annually.
That's a pretty high price tag, Governor Perry.
Larry Jordan, Corpus Christi


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If the SFD process as proposed becomes regulation, and the ELD mandate isn't struck down by the federal courts or otherwise derailed, on-site auditors may garner an extra-effective tool in their arsenal for declaring a carrier Unfit on the basis of hours, moving violations.Read More
"I've written several articles about things four-wheelers don't know about trucking and truckers, but there are some things I think they don't know about themselves that bear to be mentioned." ...Read More
Indiana, Delaware, Illinois top the rankings for violations that contribute CSA's Unsafe Driving measure. Often used by enforcement as a reason to inspect, without an attendant citation such violations can be notoriously difficult to challenge.Read More
Insurance.com's most recent consumer survey reveals some fairly common rude -- and unsafe -- practices among motorists; and: details on the Indianapolis South Split construction detour.Read More
State inspection intensity ratings range from Maryland, where 32 inspections per lane-mile of National Highway System were conducted during CSA's first two year, to Idaho, where only two inspections per lane-mile were done.Read More
In the two years since CSA's advent, the smallest carriers have had a much greater chance of getting inspected and put out of service than drivers and trucks of the largest carriers.Read More
It's important for those with carrier authority to keep tabs on their annual self-reported vehicle-miles-traveled and power-unit information for CSA scoring purposes.Read More
Run-down of the Wednesday, June 20, 2012 call hosted by the Trucking Solutions Group with FMCSA Administrator Anne Ferro on critical industry issues. Find a summation of some of the major points with a link to the entire recorded call.Read More
CSA rankings, a weight pilot program, use of heavier trucks and a new hours rule proposal are among the industry news items featured.Read More
We've brought it up from time to time here, no doubt -- no secret that the large majority of on-highway accidents involving large trucks follow an initial mistake made by the driver of a four-wheeled vehicle of one sort or another. By and large, truck drivers are justified in holding a desultory opinion of the piloting abilities of the motoring public writ large, and most keep it high in their minds navigating the nation's highways, ...Read More


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The Forest Hills Central girls basketball team needed a strong second half to win its fourth straight game with a 45-37 victory at Northview on Tuesday.
The Rangers trailed 23-14 at halftime before outscoring the Wildcats 31-14 in the second half.
"We didn't stick to our game plan in the first half, either offensively or defensively, which made it pretty difficult," FHC coach Roxanne Gallert said. "We knew that (Mackenzie) Crawford and (Maggie) Tisdale would be their power and points, and we knew how we were supposed to defend, but we were not doing that.
"We also were not finishing our shots. We knew that whey would play us in one of their zones, and we were getting good shots, but we were not making them, which I am sure was frustrating for the girls."
The Rangers trailed 30-27 after three quarters before outscoring the Wildcats 18-7 in the fourth to win the game.
"In the second half, we stuck more to our game plan," Gallert said. "We took care of the ball one possession at a time. We also played better defense and boxed out after one shot on each defensive possession.
"We gradually decreased their lead one basket at a time for the second half of the third quarter and into the fourth.
"Our second half play was some of the best basketball I have seen from this group, and I am excited about overcoming our issues from the first half the way we did this early in the season."
Mya Udell led the Rangers with 16 points while Marti Corby added 15.
"Mya Udell had a great second half with her strong penetration to the basket and getting the ball to the open players," Gallert said. "Also, freshman Jessica Fuller hit some big outside shots down the stretch which helped us gradually get the lead."


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In an earlier post we took note of the birthday of Nettie Maria Stevens, noted female geneticist whose research on chromosomes of the common fruit fly Drosophila melanogaster furthered understanding of chromosomal sex determination.
Reading about the discovery of the lost letters from DNA researcher Francis Crick to colleague Maurice Wilkins made me think about what kind of paper trail today's leading scientists are leaving. (Wilkins shared the 1962 Nobel Prize in Chemistry with Crick and James Watson for their work on the DNA model.)
When I called Jeremy Duvall and Damian Young, two of the Broad's organic chemists, to talk about the 2010 Nobel Prize in Chemistry winners, I was checking in with them to discuss the relevance of the work recognized. What was surprising to me was that the work from the winners represents not just some piece of obscure chemical synthesis minutia. This was chemistry that we use on a daily basis here at the Broad.
Today, Robert G. Edwards, a British physiologist who spent much of his career at Cambridge University, was awarded the Nobel Prize in Physiology or Medicine for developing in vitro fertilization (IVF), a technique used to help people conceive children. The procedure involves mixing eggs and sperm in a laboratory dish, and then returning the embryo to the womb to resume development.
Today, most people don't have to worry about developing a lethal infection from a tiny cut, but up until the early 20th century, infection was a severe health problem. It was not until a fateful observation in 1928 that scientists could begin a full-scale defensive campaign against bacteria. On Sept. 28 of that year, Alexander Fleming noticed that a mold growing on an old Petri dish appeared to stop the growth of bacterial colonies.
Since I work at a world-class institution where I encounter genetics and genomics research daily, it is only right to acknowledge the birthday of Gregor Johann Mendel (1852-1884), the Austrian friar whose puttering in the garden led to more than just the day's edibles.
Today is the birthday of Nettie Maria Stevens (1861-1912), whose discoveries helped researchers understand chromosomal sex determination. In the early part of the 20th century, many biologists believed that as an embryo develops, factors that a baby is exposed to during gestation (such as the mother's diet) influence whether the baby will be male or female. But Stevens and her colleagues helped demonstrate that the chromosomes we inherit determine sex, and that this happens at the moment of fertilization, not over the course of development.
As we begin the second half of 2010, a look back in the timeline of interesting – we hope – dates in science reveals that on July 1,1858 Charles Darwin first went public about his views on the evolution of species.
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Utagawa Kuniyoshi
- In this Japanese name, the family name is Utagawa.
Utagawa Kuniyoshi (歌川 国芳, January 1, 1797-April 14, 1862), also called Kuniyoshi, was a Japanese artist. He was a masters of the ukiyo-e style of woodblock prints and painting.[1]
Career[change | change source]
Kuniyoshi was part of the Utagawa school of artists.[2]
The range of Kuniyoshi's subjects included landscapes, beautiful women, Kabuki actors, cats, and mythical animals. He is known images of the battles of samurai and legendary heroes.[3] His work was affected by Western art and caricature.[1]
Tsukioka Yoshitoshi was one of his students.
His work influenced Toyohara Chikanobu.[4]
Takashi Murakami credits the influence of Kuniyoshi in his work.[3]
List of print series[change | change source]
- This list is not finished; you can help Wikipedia by adding to it.
- Illustrated Abridged Biography of the Founder (c. 1831)
- Famous Views of the Eastern Capital (c. 1834)
- Heroes of Our Country's Suikoden (c. 1836)
- Stories of Wise and Virtuous Women (c. 1841-1842)
- Fifty-Three Parallels for the Tōkaidō (1843–1845)
- Twenty-Four Paragons of Filial Piety (1843–1846)
- Mirror of the Twenty-Four Paragons of Filial Piety (1844–1846)
- Six Crystal Rivers (1847–1848)
- Fidelity in Revenge (c. 1848)
- Twenty-Four Chinese Paragons of Filial Piety (c. 1848)
- Sixty-Nine Stations along the Kisokaido (1852)
- Portraits of Samurai of True Loyalty (1852)
- 24 Generals of the Kai Provence (1853)
Gallery[change | change source]
Multi-panel impressions, tryptichs[change | change source]
Kajiwara Kagesue, Sasaki Takatsuna, and Hatakeyama Shigetada racing to cross the Uji River before the second battle of Uji during the Genpei War[5]
Yoko-e, a print in horizontal or "landscape" format[change | change source]
At the shore of the Sumida River
Single panel format[change | change source]
Miyamoto Musashi[6] killing a giant shark
Themes[change | change source]
Kuniyoshi made many images of cats.
Kuniyoshi made images which were caricatures.
References[change | change source]
- ↑ 1.0 1.1 Nussbaum, Louis Frédéric et al. (2005). "Kuniyoshi" in Japan Encyclopedia, p. 576.
- ↑ Nussbaum, "Utagawa-ryū" at p. 1018.
- ↑ 3.0 3.1 Lubow, Arthur. "Everything But the Robots: A Kuniyoshi Retrospective Reveals the Roots of Manga," New York Magazine. March 7, 2010; retrieved 2012-3-29.
- ↑ "Yōshū Chikanobu [obituary]," Miyako Shimbun, No. 8847, October 2, 1912. p. 195.
- ↑ Kitagawa, Hiroshi et al. (1975). The Tale of the Heike, pp. 511-513.
- ↑ Nussbaum, "Miyamoto Musashi" at p. 650.
- ↑ Nussbaum, "Kakinomoto no hitomaro" at p. 456.
Other websites[change | change source]
|Wikimedia Commons has media related to: Utagawa Kuniyoshi
- University of Vienna, Ukiyo-e Caricatures 1842-1905
- JapanSociety.org, Graphic Heroes, Magic Monsters
- Kuniyoshi Project
- Artencyclopedia.com, Utagawa Kuniyoshi
- Artelino.com, Utagawa Kuniyoshi


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Letters to the editor: Beyonce flap overblown by media
Are our news media desperate for breaking news? What's up with the Beyonc� lip-sync fiasco? I can't believe how much news coverage was given to this subject. With everything else going on in the world, they selected something as trivial as this to make it top priority?
Seriously, Beyonc� is one of the top female performers in the world and she certainly knows how to perform in front of any venue. If she decided to prerecord her voice and use it under those conditions, so be it. If she performed live, even better. Either way, people got to hear and see Beyonc� perform for our president's inauguration celebration.
End of story.
Why would that create a media frenzy across our great nation? To me it was degrading to the entire media. Couldn't they have selected more important news, like what the first lady was wearing? That's really more important to our national security. Or how about rising gas prices? That's big news too.
They should take a step back and really reconsider what is breaking news. They missed the boat on this one.
W.L. Galleur|Erie
GOP's electoral college plan wrong
For anyone who hasn't watched "The Rachel Maddow Show" lately, I'd like to pass on some info. Democratic congressional candidates received more than 1 million more votes than Republicans, but Republicans kept the majority in the House of Representatives in part because of gerrymandering. We witnessed this with Mike Kelly's re-election in the 3rd District without the Democratic vote.
Now it seems some states could do the same with the Electoral College vote, splitting the vote by congressional districts and making it harder for a Democrat to win the presidency.
Five states, all with Republican majorities in the legislature, have considered it, though the effort in Virginia failed.
Republicans in Pennsylvania already have the bill in committee and yet there has been no local coverage on it.
Republicans in Pennsylvania already have the bill in committee and yet there has been no local coverage on it.
People have the right to know. Go to Rachel's Web page for more, rachel.msnbc.com.
S.J. Will|Erie
Pipeline issue misunderstood
Syndicated columnist Dale McFeatters was pushing President Barack Obama to approve the Keystone XL pipeline (Erie Times-News, Jan. 27).
Well, from what I have read, the oil is consigned to China. The Chinese are buying this oil field. The benefit to the Canadian people is nil. If it was important to Canada, it would pipe its oil west on its land to the West Coast — a shorter distance. They are afraid of polluting their harbor with an oil spill.
The big benefit is to the Koch brothers and their oil refineries. The Koch brothers are the sugar daddies for the Republican Party. They reportedly gave Republicans $100 million for the last election. They want a return on their money.
Currently, oil from the newly discovered oil fields in North Dakota and Montana (more oil than Saudi Arabia) is being transported by Union Pacific Railroad to the East, West and Gulf coasts. They hauled 200,000 rail tanker cars in 2012, faster than can be handled by pipelines ("Trains carrying more oil across U.S. amid boom," Erie Times-News, Dec. 30).
Cloyd J. Rose|Erie
Gun laws need strict enforcement
I have been reading the letters to the editor about the suggestion that state Rep. Greg Lucas, of Edinboro, R-5th Dist., made about arming teachers in school. Well, at least he took a stand and made a suggestion
Lucas has only been in office a few weeks and is concerned about this gun control issue. However, all the people who are bashing him have not made a suggestion about how to cope with the problem. I would like to call on all the politicians, the district attorney and Erie County judges to act. I would like to see some stiffer jail sentences for people committing a crime with a firearm.
Put these people away for a 25-year sentence, no provisions for being a juvenile. If you play the game, you pay. I am amazed at how many young people manage to get possession of a firearm. Of course, they are stolen or straw-purchased. The people who delve into this type of crime need long jail sentences.
The crime situation involving a firearm can only be solved with enforcement of strict laws with no bleeding hearts.
Fred Leonardi|Edinboro
Humane Society has tough job
Lisa Stiles and Merle Wolfgang, investigating officers with the Humane Society of Northwestern Pennsylvania, are doing their best to help the cats and dogs and people who have them.
They were out to my place and helping me with the barn cats. They were very helpful doing their job. I hope people will support the Humane Society. It is always in need of food and donations. Please help.
I have been giving cat food to them as well as rescuing stray cats. Please spay or neuter your cats. I do. Also, stop the abuse of cats and dropping them off everywhere and anywhere. You think you are getting away with it. I don't think so. God will judge you. I feel so sorry for the stray cats.
LaRue Whitney|North East
America becomes 'land of the freebies'
Thank you, letter writer Dave Fresch, for putting the national debt into an easy-to-understand format ("Debt lessons offered," Erie Times-News, Jan. 25).
Certainly, no one would run his or her family budget like the federal government has been run. Further, no family should be this far in debt.
Unfortunately, this also brings a greater understanding as to why Washington is so polarized. We elect officials and send them to D.C. in hopes of solving the debt crisis. These representatives go with great hopes and ideals only to resign themselves to the opinion that the debt problem is too big to handle.
It is no wonder that those representatives who are digging in their common-sense, debt-cutting heels for us are being criticized as being too inflexible. Ultimately, the political merry-go-round is perpetuated and the debt ceiling is extended.
It is time for these representatives to solve this once and for all and bring this country back to the land of the free instead of the land of the freebies.
Gregory L. Swanson|Erie


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Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
As part of this research, Dr. Morrison's lab decided to optimize the off-the-shelf assay to see whether changes could detect a broader range of cancer cells. "In addition to going longer and detecting a 10-fold increase in tumorigenic cells, if we use more highly immunocompromised mice we get almost a 200-fold increase in the detectable frequency of tumorigenic cells. Co-injection with Matrigel™ (which generally improved cell engraftment and thus increases cell survival without conferring tumorigenicity) yielded up to a 20-fold increase.
"Modifications in xenograft assays combine to dramatically increase the detectable frequency of tumorigenic cells, so that they were actually quite common," Dr. Morrison said. In a larger study, initial data indicated that one in one million cells has the potential to form a tumor but, by slightly modifying the assay, the ratio changed to one in four.
"Therefore, for the first time in cancer biology, we can study tumorigenesis from single human cancer cells in vivo." Rather than proving that metastatic melanoma doesn't follow the cancer stem cell model, it proves that the tumorigenic cells are frequent.
"A separate question is whether the 28 percent of cells in which we can detect tumorigenic capacity are intrinsically different from the nontumorigenic cells that we cannot detect," Dr. Morrison continued. In his experiments, involving 50 markers, in which 17 that are frequently heterogeneously expressed, the positive and negative fractions resulting in tumorigenesis. "We are unable to detect a hierarchical organization in melanoma, having looked very hard." If such a marker is eventually found, he suggests it will have a very shallow hierarchy.
The second portion of the workshop, led by Franziska Michor, Ph.D., computational biologist at Memorial Sloan-Kettering, addressed therapeutic resistance and the origin of cancer stem cells.
"If you have a drug that kills tumor stem cells, then over time, the tumor stem cell population will die out. If you have drugs that kill tumor cells but leave the cancer stem cells intact, then the tumor cell population will grow back," she hypothesized.
In investigating the molecular response to imatinib among 68 patients, Dr. Michor found two distinct response slopes—one at 20 days life span and another at 125 days life span during therapy—with two distinct decay rates. The main body of cancer cells was depleted at a rate of 5% per day, while the other cells were depleted by 0.8% per day. This dramatic difference indicates that there are distinct subpopulations of cancer cells.
The idea that distinct subpopulations of cancer cells exists is further supported by a German study of patients who discontinued imatinib therapy after three years. Within one week, the cancer cells rapidly rebounded in 60% of the patients, peaking at levels higher than baseline. Therefore, it appears that cancer stem cells were not depleted by the drug and are, in fact, driving the disease. "There's something going on that leads to resistance to imatinib," Dr. Michor said.
Because imatinib is so specific as to be useless if a single base changes, it may be possible to answer that question while exploring the origin of tumorigenic cells. To do so, she turned to a mathematical analysis of the evolution of cancer stem cells, focusing upon identifying the mutation that triggered their drug resistance and considered several theories: that tissue-specific stem cells accumulated all the mutations needed to transform into tumor cells, that progenitors also accumulated the necessary mutations, and that the mutation conferring self-renewal to progenitors first arises in the stem cells without changing their phenotype.
Based upon her work with JAK2V617F mutations, she determined that progenitor cells are the most likely cell of origin for those mutations, which lead to cancer. This finding also may be relevant to other tumor types in tissues organized with a differentiation hierarchy.
Her next step was to identify the predicted first mutation. Using primary glioblastomas, Dr. Michor investigated cells in the subventricular zone of the brain that targets for transfection. Using mathematical modeling of a small number of cell divisions, she found that, "self-renewing transit amplifying cells are the most likely cell of origin for gliomas."
In general discussions, Dr. Michor broached the idea that "some cancers really seem to follow the cancer stem cell model but are reversibly organized." The role of microenvironments also was touched upon and should be the subject of additional research. "Tumor microenvironments are very important, but we don't know how," Dr. Morrison said. Microenvironments appear to kick off morphogenetic processes, so the markers that often are used become moving targets that, ultimately, are of little value, Dr. Michor added.
There are a lot of fundamental questions that remain about cancer stem cells, Dr. Morrison emphasized. "The way we think about cancer stem cells will change dramatically during the next five years. Cancer is so endlessly resourceful."
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Keep veterinary patients warm with rice buddies
Jun 01, 2012
To keep patients warm after surgery, we place rice buddies with them in their kennels. To make a rice buddy, fill a tube sock with rice, tie off the end, and warm it in the microwave for two minutes, depending on the appliance. They stay warm for a while and they're an inexpensive way to keep all of your patients warm. You can even place one by the patient before the surgery begins. To keep them clean, we cover them with an OB sleeve for every new patient.
—Crystal Vollmer, CVT
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Lifestyles Photos
CrossFit Dallas Central pushes to be "Fittest on Earth"
Photo: Vernon Bryant/Staff Photographer
Trey Kubacak of the CrossFit Dallas Central team lays on the ground as teammate Meredith Ramsey playful attempts to roll a bar over him after a workout at CrossFit Gym.
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