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There are two types of colorectal cancer:
Consider the following statistics related to colorectal cancer:
When colorectal cancer is diagnosed, tests will be performed to determine how much cancer is present, and if the cancer has spread from the colon or rectum to other parts of the body. This is called staging, and it is an important step toward planning a treatment program. The stages for colorectal cancer are as follows:
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Dr. Alex Johnson to Become Fourth President of Cuyahoga Community College
5/15/2013, 8:38 a.m.
CLEVELAND – Dr. Alex Johnson, who led Cuyahoga Community College's Metropolitan Campus from 1993 to 2003, will return to the College in July as its fourth permanent president, the Board of Trustees announced today.
"Since leaving his position as Metropolitan Campus president a decade ago, Dr. Johnson has gained vital experience in two very diverse community college environments," said Jerry L. Kelsheimer, chairman of the Board of Trustees. "He brings a unique perspective that is both internal and external, and we are extremely pleased that Cuyahoga Community College's continued growth will be carried out under his strong leadership."
Johnson is currently president of the Community College of Allegheny County (CCAC), where he focuses on strengthening the college's core mission of providing affordable access to quality education for nearly 60,000 students annually at nine campuses and centers in greater Pittsburgh. After leaving Tri-C in 2003, he became chancellor of Delgado Community College in New Orleans, serving in that capacity during Hurricane Katrina and its aftermath.
In returning to Tri-C, Johnson will succeed Dr. Jerry Sue Thornton, who has guided unprecedented institutional development during 21 years as president. Thornton announced in January that she would retire, effective June 30.
"As Metropolitan Campus president I had the great privilege to serve under and work closely with Dr. Thornton for 10 years," said Johnson. "It is indeed both an honor and very humbling that the Board has the confidence in my ability to build upon her tremendous legacy.
"During its 50-year history, Tri-C has become noted for innovations in the use of technology for instructional design and delivery, cultural advancements like JazzFest, and other achievements including the Corporate College. I look forward to continuing to foster such achievements befitting a League for Innovation institution, but more importantly continuing to advance its 'learning-centered' philosophy to improve access, learning and attainment."
Finalists participated in College forums last week at the Metropolitan Campus. Kelsheimer said additional meetings with faculty, staff and students will be scheduled over the next four to six weeks after Johnson winds down the responsibilities of his current position.
"Thanks to Tri-C's reputation and record of success, there was tremendous interest in this opportunity," said Kelsheimer. "Ultimately, Dr. Johnson was the clear choice among a very strong group of candidates.
"In Dr. Johnson, we have found a strong leader with the ability to extend his influence beyond the College itself. He has an absolute commitment to student success and to supporting our faculty and staff and has demonstrated his ability to manage fiscal affairs responsibly. Moreover, he will be aligned and engaged with the community's needs and interests, and willing and able to evolve our organization in response to a changing environment."
The 20-member Presidential Search Advisory Committee, chaired by Trustee David W. Whitehead and including faculty, staff and community representation, narrowed the field to three finalists after interviewing eight candidates; one of the three subsequently withdrew from consideration for family reasons.
An executive-search firm had previously identified 15 "top candidates" after reviewing more than 40 applications. In addition to Johnson the committee interviewed Dr. Terrence J. Burgess, president of San Diego City College; Dr. Stephen M. Curtis, president of Community College of Philadelphia; Dr. Craig Foltin, executive vice president/treasurer, Administration & Finance, at Tri-C; Dr. Lars A. Hafner, former president of the State College of Manatee-Sarastota (Florida);

subset: commoncrawl


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And so it goes: Boring dialogue scene / Teenage Daughter wanders through a hallway / boring dialogue scene / Teenage Daughter pokes around the cellar... You get the gist of it. Now imagine reading this paragraph for 84 minutes straight and you've got half an idea of what The Messengers is all about. Ah, and the "fake jolts." Oh how I hate these things -- and yet they're freakin' everywhere in my very favorite movie genre. Here's how a "fake jolt" works: Some clueless character is wandering down a hallway / through a cellar / inside an attic, and since the director has no good idea where the scene is actually headed, he'll just throw a screeching cat! or a slamming door! into the sequence, usually accompanied by a harsh SKREEK! from the film's music composer. There's no actual build-up of tension, mood or atmosphere; just a pretty girl, a shadowy hallway and a loud random noise! that arrives cheaply and apropos of nothing. Phooey.
Today we read from the Horror Movie Bible, chapter 13, verse 666: "When there are no Asian horror movies left to remake, Asian filmmakers will alight to Hollywood and create Americanized versions of The Ring, The Grudge and Dark Water and lo the PG-13 rating will be applied -- and it will be not good." But since The Messengers was written by a really cool horror geek named Mark Wheaton, I walked into an opening day matinee screening of the flick with some high hopes. Despite everything the TV spots, the trailers and the pre-release buzz had been telling me, I was actively intent on trying to enjoy The Messengers. Sorry to say that my pilot light of enthusiasm was snuffed out after less than twelve minutes of on-screen activity. This is a stunningly inert, painfully derivative, shamelessly cheap and aggressively dull ghost story that delivers nothing you haven't seen before. About 43 times.
Clocking in at a scant 84 minutes (and that's including a tiresome prologue and a lengthy opening credits sequence), The Messengers is The Grudge on a farm (The Grarm!) -- and it's about as thrilling as that description implies. It's about a family of four (Mom, Dad, Teenage Daughter, Mute Boy Toddler) who bail on Chicago in favor of Nowheresville, North Dakota. (Dad's got a bee in his bonnet about becoming a sunflower farmer, darnit, and nothing's gonna get in the way of that dream!) While Mom, Dad and Mute Toddler go about settling into their new home, teenage daughter has a problem; basically, she sees shadows, visions, apparitions, etc. -- and of course nobody believes her. (There's a ridiculously prolonged backstory about why Mom and Dad don't completely trust Teenage Daughter, but it's much too silly to get into at this point.)
To be completely honest, I think the "fake jolt" is the worst thing to happen to horror movies since the invention of the PG-13 rating, but I'm digressing here. We're talking about a horror movie made for people who don't really want to be scared. The target audience member for The Messengers is a bored 14-year-old girl who wants to squeal with her girlfriends in obvious and simplistic (perhaps even Pavlovian) fashion. But considering that the flick is being dumped into theaters during Super Bowl weekend (and without a chance for the press to check it out, natch) after sitting on a shelf for several months, I'm guessing that even the teeny-boppers will be skipping this one.
The screenplay is a morass of tired exchanges and blatant ADR blather; the story has more whiskers than a mall full of cat shops; the editing is clumsy and clunky; and the PangBrothers' directorial style could be best described as "deadly dull, with many crane shots." And the actors certainly don't help a whole lot. As Dad, Dylan McDermott manages to escape with his reputation intact, and the young Kristen Stewart will certainly survive to star in much better films, but Penelope Ann Miller (as Mom) is really quite floridly awful, and just you wait till John Corbett (with a mullet) shows up as a sweaty farmhand. Miscast and misused, the guy's one of the only bright spots in the whole movie, although not for the reasons he was probably shooting for.
Not nearly bad enough to be "so bad it's good," The Messengers is just plain old bad; dry, dull and drab across the board, with only a few stray moments of unintentional levity. It's the laziest and most inanimate "psychological thriller" since last year's When a Stranger Calls. (As a double feature, these flicks would be more powerful than a Nyquil Thorazine cocktail.) Basically, if you can find one unique or exciting component in this movie, you simply need to see more movies. Better ones, too.


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Question about a small problem with my Sig
Tools and Technologies
Handguns: Autoloaders
> Question about a small problem with my Sig
Safety First
January 7, 2003, 08:54 PM
The rear sight and hammer have some sharp edges..Now my question may seem a little dumb to you long time gunaholics..But can anyone tell me how to take the sharp edge off and if so how??
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January 7, 2003, 09:08 PM
Do you mean edges that look sharp, or edges that have cut you?
January 8, 2003, 01:22 AM
You'll hve to refinish whatever parts you doctor on, but assuming I understand the question correctly, I would use a peice of fine emory cloth to round off sharp edges and burrs on the exterior of your piece. I'm guessing you have something poking you or cutting your shirts from the holster?????
Safety First
January 8, 2003, 07:19 PM
Sharp edges are around the outside of the hammer and top of the rear sight,sometimes when either presenting or just by accident my hand or finger will hit the sharp edges. Never drawn blood but if there is an easy fix, I would like to smooth them down. I am not sure if that will harm the finish...if it would not then I could use the emory cloth...what do you think ??
January 8, 2003, 08:17 PM
You could do a buff job with a Dremel...but refinishing may be a hassle.
Which model do you own? If it's for CCW, and the edges really bother you, consider a meltdown, or have someone like ROBAR do the edge removal for you. Personally, if it doesn't draw blood or tear up my clothes, then I leave it as is.
Ala Dan
January 8, 2003, 11:01 PM
Greeting's All,
First off, what model SIG are we talking about?
SIG does have "short throw" combat trigger's available
for some models.
Best Wishes,
Ala Dan, N.R.A. Life Member
January 8, 2003, 11:04 PM
Get a dealer, 'smith, or good pal with the SIG sight tool to remove the rear sight. Use some emery and round off those sharp edges.
As for the hammer, I suggest you remove the slide and use some emery on the hammer. With the slide off you can get 360-degree access to the hammer and an errant stroke of the emery won't inadvertently damage the slide.
Just my two cents,
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|HomeAvian Influenza and EINetVirtual SymposiumHuman Avian Influenza CasesAbout APEC-EINetNewsbriefs> Browse• SearchAPEC EconomiesPeople DirectoryTeaching & LearningResearch ResourcesContact Us
Vol. VIII, No. 25 ~ EINet News Briefs ~ Dec 02, 2005
*****A free service of the APEC Emerging Infections Network*****
APEC EINet News Briefs offers the latest news, journal articles, and notifications for emerging infections affecting the APEC member economies. It was created to foster transparency, communication, and collaboration in emerging infectious diseases among health professionals, international business and commerce leaders, and policy makers in the Asia-Pacific region.
In this edition:
- Romania: Avian influenza threat returns
- East Asia: Cumulative number of human cases of avian influenza A/(H5N1)
- Viet Nam: Culling of birds for avian influenza control
- China: Additional avian influenza outbreak; WHO to help investigations
- China: Fake avian influenza vaccines; development of new vaccine for birds
- Indonesia: Additional confirmed case and suspected cases of human bird flu
- Indonesia (West Java; Sulawesi): Anthrax outbreaks
- Indonesia (West Nusa Tenggara): Outbreak of malaria
- Russia (Nizhniy Novgorod): Viral hepatitis A outbreak continuing
- Russia (Orenburg): Hemorrhagic fever with renal syndrome outbreak
- USA: CDC updating disease-control rules affecting travelers
- USA: FDA approves West Nile test to screen blood
- Canada: Sprouts blamed in big Ontario Salmonella outbreak
- USA/Canada: USA to ease restriction on Canadian poultry
1. Updates
- Influenza
- Dengue
- West Nile Virus
2. Articles
- CDC EID Journal, Volume 11, Number 12-December 2005
- Severe Clostridium difficile--Associated Disease in Populations Previously at Low Risk--4 States, 2005
- Early-Onset and Late-Onset Neonatal Group B Streptococcal Disease--United States, 1996-2004
- Screening HIV-Infected Persons for Tuberculosis--Cambodia, January 2004--February 2005
- East Asia: Many H5N1 cases clustered in families
- Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature
- Effects of local variation, specialty, and beliefs on antiviral prescribing for influenza
- Annual universal influenza vaccination: ready or not?
- New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China
- USA: Produce linked to more disease cases than poultry
3. Notifications
- World AIDS Day --- December 1, 2005
- Conclusions and Recommendations of the Advisory Committee on Poliomyelitis Eradication--Geneva, Switzerland, October 2005
- Licensure of a Combined Live Attenuated Measles, Mumps, Rubella, and Varicella Vaccine
4. APEC EINet activities
- APEC e-Health seminar; Pandemic influenza videoconference
5. To Receive EINet Newsbriefs
- APEC EINet email list
Romania: Avian influenza threat returns
Virus H5, responsible for the development of avian influenza, was found following tests run on samples from a turkey in the village of Scarlatesti, the commune of Ciresu, Braila County. This focus of avian flu adds to those already found at Ceamurlia de Jos, Maliuc and Caraorman, Tulcea County in Oct 2005. The infected samples at Scarlatesti will be sent for further testing at a UK laboratory. Braila Prefect Nicolae Mitroi ordered that grade one quarantine be immediately enforced in the village of Scarlatesti. Manned road blocks consisting of gendarme and police crews prevent humans, animals and poultry from leaving the village of Scarlatesti until the avian flu focus has been completely eradicated, and entry into the focus area is only allowed after the individuals concerned have been briefed accordingly. The population is also instructed on the danger posed by avian influenza. Authorities at Ciresu take measures aimed at ensuring a steady supply of foodstuffs and other bare essentials, the supplies being ferried without allowing any access to the isolated area. Local measures have been taken to isolate the virus. Experts with the Braila Sanitary Veterinarian and Food Safety Department are attempting to eliminate the focus of the viral infection at Scarlatesti. The vaccination of the local populace began 27 Nov 2005, and so did the killing of the fowl in the village, with compensation. Given that the closest populated location is 3 km away from the village of Scarlatesti, bird killings only apply within the radius of the village. Scarlatesti has nearly 400 homesteads, with an estimated 15 000 fowl.
The European Union maintains the restrictions on imports of poultry from 6 counties in eastern Romania: Tulcea, Constanta, Galati, Braila, Ialomita and Calarasi, but will lift the ban for the other regions starting 1 Dec 2005, the National Sanitary Veterinarian and Food Safety Authority says. However, the ban on imports of live fowl from Romania is still in force. According to the official notifications to the OIE, the vaccination of poultry against avian influenza is not prohibited in Romania. However, no avian vaccination has been reported. Romania has not reported any cases of bird flu in humans so far.
OIE avian influenza H5 report
East Asia: Cumulative number of human cases of avian influenza A/(H5N1)
Cumulative number of confirmed human cases of avian influenza A/(H5N1), 16 Dec 2004 to present:
Economy / Cases (Deaths)
Indonesia / 12 (7)
Cambodia / 4 (4)
Thailand / 4 (1)
Viet Nam / 66 (22)
China / 3 (2)
Total / 89 (36)
Total number of confirmed human cases of avian influenza A/(H5N1), 26 Dec 2003 to present: 133 (68)
Viet Nam: Culling of birds for avian influenza control
Ho Chi Minh City has begun poisoning pigeons and other wild birds as it moves to prevent avian flu from spreading into the city, an official said 25 Nov 2005. The virus has this week also surfaced in the south where Ho Chi Minh City is located. "We will make sure that no birds are left in the city to minimize the risk of bird flu," Huynh Huu Loi, Director of Ho Chi Minh City's Animal Health Department, said. Loi said beside the poisoning campaign, authorities would also move pet birds outside the city until Vietnam is free of bird flu. Ho Chi Minh has banned poultry farming even though it has had no human cases since Dec 2004. Most of the outbreaks in recent weeks have been in the north. But the virus has spread to the south with the province of Long An reporting its first flu outbreak in poultry.
A "stamping out" policy might, at times, become a controversial issue, especially when protected species or rare animal breeds may be affected. The U.N. FAO says controlling avian influenza in poultry is the most effective public health measure. Juan Lubroth, an FAO officer in charge of infectious animal diseases, said culling wild birds is likely to be ineffective. "Wild bird species found in and around cities are different from the wetland waterfowl that have been identified as carriers of the avian influenza virus," Lubroth said. FAO recommends improved veterinary services, emergency response and the culling of domesticated fowl exposed to the disease as the most effective means of controlling bird flu. (Promed 11/25/05, 11/30/05)
China: Additional avian influenza outbreak; WHO to help investigations
At the invitation of the Chinese Ministry of Health, WHO is participating in a joint mission to Anhui Province to investigate circumstances surrounding the recent detection of 2 human cases of H5N1 infection in that province. Both fatal cases, which were confirmed by laboratory tests, occurred in female farmers aged 24 and 35 years. The team will be gathering information about the sources of exposure in these 2 cases and will also assess the effectiveness of public health measures introduced in the areas. The 2 cases lived some distance apart; no link between the 2 cases is thought to exist. China has recently experienced a recurrence of outbreaks of highly pathogenic H5N1 avian influenza in poultry. Beginning in mid-October 2005, officials have reported 25 fresh outbreaks in poultry in 9 provinces. To date, the country has reported 3 laboratory-confirmed cases of human infection, of which 2 were fatal. (Promed 11/25/05, 11/26/05, 11/29/05)
China: Fake avian influenza vaccines; development of new vaccine for birds
The UN said 23 Nov 2005 that it supports China's massive animal vaccination programme to combat bird flu, but cautioned that quality control on vaccines must be assured. Joseph Domenech, chief veterinary officer of the UN FAO, said agency officials would be among those visiting Chinese laboratories. China�s State Council asked local governments to support and supervise designated vaccine producers, and strike hard at those manufacturing fakes. Separately, China has developed a new vaccine for use on birds against the avian influenza strain, media reports said. The vaccine reportedly has the advantage of fighting another common bird disease, as well as the H5N1 influenza strain. It identified this as avulavirus APMV-1, also known as Newcastle disease. "What's more, the new vaccine is safer, more convenient to use and cannot kill newborn chicks," it said. The new vaccine can apparently be applied by spraying. "In addition, the cost of the new vaccine in mass production is only 1/5 that of the previous vaccine." The country was preparing to put the vaccine into mass production. (Promed 11/26/05, 12/1/05)
Indonesia: Additional confirmed case and suspected cases of human bird flu
A 25-year-old Indonesian woman who died has tested positive for avian influenza, a senior researcher at the Health Ministry said 30 Nov 2005. Endang Mamahit said the woman had been treated at the Sulianto Saroso Hospital, Jakarta's hospital for treating avian influenza patients. She died 29 Nov 2005. "We have conducted [a] test and the [result is] positive," Mamahit said, adding that the result had to be confirmed by a WHO laboratory. The woman had reportedly been in contact with dead chickens before being admitted to the hospital 24 Nov 2005. In addition, health officials are waiting for WHO confirmation of local tests which showed that a 35-year-old man who died 19 Nov 2005 was the country's eighth fatality. Indonesia has had 7 deaths from avian influenza confirmed by the WHO laboratory. Another 5 people have been confirmed to have contracted the virus but have survived. Most human bird flu cases in Asia have been blamed on direct or indirect contact with infected poultry.
Meanwhile, health minister Siti Fadilah Supari said that the mass production of Tamiflu in the country would start in 3-5 months. The minister said the government would appoint state-owned pharmaceutical companies to make Tamiflu under the generic name oseltamivir phosphate. Siti said Indonesia had obtained permission from the distributor of Tamiflu, Roche AG, to produce the drug only for the domestic market. The government will produce about 20 million Tamiflu tablets. "The drug will only be produced according to our needs or a minimum of 10 percent of the country's population (of around 220 million people). At present, we have 800 000 tablets provided by donor countries such as Australia, Japan and Singapore," Siti said. Siti said her office had discussed with India, China and South Korea the possible provision of raw materials for Tamiflu production here. (Promed 11/29/05; 11/30/05)
Indonesia (West Java; Sulawesi): Anthrax outbreaks
Separately, health officials in the South Sulawesi city of Makassar carried out house-to-house checks for signs of anthrax infections in humans. Makassar's health office head Naisah said that after the first case of animal anthrax infection was confirmed 11 Nov 2005, authorities set up a centre to deal with the outbreak at Tamangapa village, with more than 200 people appearing for checks. She said health officials had taken blood samples from 11 people. 4 of them showed superficial symptoms of anthrax and the rest were people with a high susceptibility to the disease because of their work. More than 20 cows and water buffalos were believed to have died of anthrax although only 4 cases were confirmed. A ban on the movement of livestock in and out of the area was being enforced, while officials were gearing up for a massive vaccination campaign, with 65 000 doses being prepared for distribution. Sick animals were being treated with antibiotics. (Promed 11/18/05, 11/27/05)
Indonesia (West Nusa Tenggara): Outbreak of malaria
Russia (Nizhniy Novgorod): Viral hepatitis A outbreak continuing
Russia (Orenburg): Hemorrhagic fever with renal syndrome outbreak
USA: CDC updating disease-control rules affecting travelers
Federal officials proposed rule changes to make it easier for public health authorities to keep travelers from bringing infectious diseases into the US or spreading them between states. The changes would require airlines and ship operators to report passengers who have certain signs of illness and to keep lists of passengers for at least 60 days after arrival, CDC announced. The proposed rules also expand the definition of ill travelers to include those with influenza-like illness, and they provide more specific legal protections for people placed in quarantine. The Department of Health and Human Services has authority to use isolation and quarantine to keep people with any of 9 infectious diseases out of the country. Pandemic influenza was added to the list this year; the others are cholera, diphtheria, tuberculosis, plague, SARS, smallpox, yellow fever, and viral hemorrhagic fevers. The proposed rule changes are largely a result of the SARS experience in 2003, when the CDC had a lot of trouble tracking down and alerting passengers who had been on flights with suspected SARS case-patients, officials said.
In the past, passenger lists often have been purged within 48 hours, and if a disease threat emerged after the fact, it became very difficult to recover passenger names and contact information and seating charts, Dr. Marty Cetron, director of the CDC Division of Global Migration and Quarantine, explained. The proposal also calls for airlines to ask passengers to provide post-arrival contact information for potential use by public health officials, though this would be voluntary. CDC is "hopeful and optimistic" that most people would accept assurances that the information would not be used for other than public health purposes, Cetron added. The updated regulations also require the pilot or ship captain to report to the CDC any passenger who has certain signs and symptoms suggesting 1 of the 9 diseases of concern, Cetron said. As things stand now, he explained, sick travelers are not usually reported until well after their trip and generally are identified through traditional public health surveillance. The new regulations also include more detailed due-process rules for people placed in quarantine because of exposure to a disease, Cetron said. The proposed rules empower authorities to hold a person for 3 days, after which a formal decision must be made whether to quarantine or not. In addition, there must be an opportunity for a hearing before an independent arbiter. Also included in the proposed changes is "explicit authority to offer vaccination, prophylaxis, and other appropriate medical interventions on a voluntary basis" to people in quarantine. The CDC will accept comments on the proposed rules for 60 days. (CIDRAP 11/22/05)
USA: FDA approves West Nile test to screen blood
Canada: Sprouts blamed in big Ontario Salmonella outbreak
Salmonella bacteria are found in the intestines of animals and can contaminate raw produce that have been in contact with impure water, animal manure, or an infected food handler. Symptoms of infection usually begin from 12 to 36 hours after a person consumes a contaminated food. The recommended safety step of soaking seeds in a calcium hypochlorite solution is not completely effective, the agency said. To reduce the risk of illness, the US Food and Drug Administration advises consumers to cook all sprouts thoroughly before eating them and to ask that raw sprouts not be added to restaurant sandwiches and salads. Most cases of Salmonella infection resolve without medical treatment, but the pathogen can cause serious and sometimes fatal illness in children, elderly people, and those with weak immune systems. (CIDRAP 12/1/05 http://www.cidrap.umn.edu/cidrap/ )
USA/Canada: USA to ease restriction on Canadian poultry
1. Updates
During week 47 (Nov 20 � Nov 26, 2005), influenza activity occurred at a low level in the US. 22 (1.8%) specimens tested by U.S. WHO and National Respiratory and Enteric Virus Surveillance System (NREVSS) collaborating laboratories were positive for influenza. The proportion of patient visits to sentinel providers for influenza-like illness (ILI) and the proportion of deaths attributed to pneumonia and influenza were below baseline levels. 23 states, New York City, the District of Columbia, and Puerto Rico reported sporadic influenza activity, and 27 states reported no influenza activity. (CDC 12/2/05 http://www.cdc.gov/flu/weekly/ )
Avian/Pandemic influenza updates
- WHO �Influenza pandemic threat: current situation�: http://www.who.int/csr/disease/avian_influenza/pandemic/en/index.html. Comprehensive information on the avian influenza 7-9 Nov 2005 meeting, including presentations, are available at: http://www.who.int/mediacentre/events/2005/avian_influenza/en/index.html WHO recommendations relating to travelers coming from and going to countries experiencing outbreaks of highly pathogenic H5N1 avian influenza: http://www.who.int/csr/disease/avian_influenza/travel2005_11_3/en/index.html. WHO does not recommend any restrictions on travel to any areas affected by H5N1 avian influenza; WHO does not recommend screening of travelers coming from H5N1 affected areas; WHO advises travelers to avoid contact with high-risk environments in affected countries
- WHO/WPRO (Regional office for the Western Pacific) website on avian influenza: http://www.wpro.who.int/health_topics/avian_influenza/overview.htm
- Latest FAO updates on avian influenza: http://www.fao.org/ag/againfo/subjects/en/health/diseases-cards/special_avian.html. Includes maps documenting the latest avian flu outbreaks and an interactive map displaying the timeline of the outbreaks. Documents from the avian influenza meeting (7-9 Nov 2005) are now available.
- Latest OIE updates on avian influenza: http://www.oie.int/eng/en_index.htm. Includes documents from the avian influenza 7-9 Nov 2005 meeting. A press release on the 24th Conference of the OIE Regional Commission for Asia, the Far East and Oceania - Seoul (Republic of Korea) 15-18 November 2005 is also available.
- The CDC website on pandemic influenza: http://www.cdc.gov/flu/pandemic.htm has been updated; for avian influenza (available in Chinese, Korea, Vietnamese, and Japanese): http://www.cdc.gov/flu/avian/ (Key Facts and Q&A updated 25 Nov 2005).
- The US government�s official Web site for pandemic flu: http://www.pandemicflu.gov/.
- Influenza information from the US Food and Drug Administration: http://www.fda.gov/oc/opacom/hottopics/flu.html. Q & A on Using PPE During Influenza Outbreaks, Including Bird Flu: http://www.fda.gov/cdrh/emergency/flu_qa.html.
- PAHO�s latest updates on avian influenza: http://www.paho.org/ Includes press release on the Summit of the Americas.
- American Public Health Association (APHA) information on Influenza (http://www.apha.org/preparedness/influenza.htm) and Avian Influenza (http://www.apha.org/preparedness/avian.htm).
- The American Veterinary Medical Association information on avian influenza: http://www.avma.org/public_health/influenza/default.asp
Meanwhile, the hospitals Pasar Rebo and Budi Asih, both in East Jakarta, have added more beds along their corridors, after dozens of new dengue patients were admitted to the hospitals 24 Nov 2005. At Pasar Rebo hospital, 21 of 72 dengue patients were treated on additional beds along the corridors, while in Budi Asih, 22 of 55 patients were treated along its corridors. Despite the increasing number of people treated for dengue, the city administration has refused to declare the dengue outbreak as an extraordinary occurrence, which would require the city administration to pool its resources to fight the outbreak. Jakarta Health Agency spokesman Evy Zelvino said the number of dengue cases had continued to increase over the last few months as the rainy season approached. Dengue fever is transmitted by the Aedes aegypti mosquito, which is most active during daylight hours. She said that the only way to stop the spread of the disease was to drain receptacles, cover bathing tanks and bury used cans, as there is no vaccine for dengue. According to the Jakarta Health Agency, the capital has recorded 16 840 cases of dengue from January to October 2005, with 74 deaths [a CFR of 439 per 100 000]. Over the last few years, the agency's figures show that the number of cases of dengue fever in greater Jakarta stood at 15 360 in 1998, 3998 in 1999, 8729 in 2000, 8820 in 2001, 5750 in 2002, and 14 071 in 2003. (Promed 11/20/05; 11/30/05)
Hong Kong
Philippines (Pangasinan)
Malaysia (Kuala Lumpur)
West Nile Virus
2. Articles
CDC EID Journal, Volume 11, Number 12-December 2005
CDC Emerging Infectious Diseases Journal, Volume 11, Number 12-December 2005 issue is now available at: http://www.cdc.gov/ncidod/EID/index.htm. The following expedited articles on influenza are available online: Making Better Influenza Virus Vaccines, P. Palese; Nonpharmaceutical Interventions for Pandemic Influenza, International Measures, World Health Organization (WHO) Writing Group and; Nonpharmaceutical Interventions for Pandemic Influenza, National and Community Measures, World Health Organization (WHO) Writing Group.
Severe Clostridium difficile--Associated Disease in Populations Previously at Low Risk--4 States, 2005
Early-Onset and Late-Onset Neonatal Group B Streptococcal Disease--United States, 1996-2004
Screening HIV-Infected Persons for Tuberculosis--Cambodia, January 2004--February 2005
East Asia: Many H5N1 cases clustered in families
Most human cases of avian flu are believed to have stemmed from exposure to sick poultry. The virus has not yet shown an ability to spread easily between people. Researchers previously identified 1 cluster, involving a young Thai girl and her mother and aunt in Sep 2004, as the probable result of person-to-person transmission. Too little information is available to conclude whether the virus spread from person to person in any of the other families, the report says. Family clusters don't necessarily mean the virus is spreading from person to person. They may simply mean that relatives were exposed to H5N1-infected poultry at the same time. However, in 3 family clusters, all in Viet Nam, the first and second patients fell ill more than a week apart, which suggests that they probably didn't acquire the virus from the same source at the same time, the report says. The authors also found that family clusters were slightly more common in the period from Dec 2004 through Jul 2005 than they were in the preceding year: 9 clusters in 243 days, or 3.7 per 100 days, versus 6 clusters in 365 days, or 1.6 per 100 days (relative risk, 2.3; 95 percent confidence interval, 0.8 to 6.3). The difference was similar when the researchers compared the period from Dec 2004 through Jul 2005 with the same 8-month period a year earlier.
Although this increase was not significant, the authors write, "We believe any cluster of cases is of great concern and should be promptly and thoroughly investigated because it might be the first indication of viral mutations resulting in more efficient person-to-person transmission." The researchers defined a family cluster as 2 or more family members with lab-confirmed H5N1 avian flu or 2 or more family members with severe pneumonia or respiratory death, when at least 1 member had confirmed H5N1. Of the 41 patients in the 15 family clusters, 25 (61 %) died. Another 4 patients recovered, while 3 were never sick even though they tested positive for the virus. The outcomes for the other 9 patients were unknown. The article says that family clusters are still occurring, but they "do not appear to be increasing as a proportion of total cases." In line with previous reports, the authors also note a decline in the overall death rate for human cases: 32 of 44 cases (73 %) from Dec 2003 through Nov 2004, versus 23 of 65 cases (35 %) from Dec 2004 through Jul 2005. (Promed 11/29/05)
Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature
Effects of local variation, specialty, and beliefs on antiviral prescribing for influenza
Annual universal influenza vaccination: ready or not?
New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China
USA: Produce linked to more disease cases than poultry
To limit produce contamination, Caroline Smith DeWaal of CSPI commented, "FDA should require growers to limit the use of manure to times and products where it poses no risk. And packers and shippers should mark packaging to ensure easy traceback when fruits and vegetables are implicated in an outbreak." Seafood was implicated in the largest number of outbreaks, 899, but the outbreaks were relatively small at about 10 cases each, for a total of 9,312 cases. The other leading illness-causing food categories were beef and beef dishes, 438 outbreaks with 12,702 cases, and eggs and egg dishes, 329 outbreaks with 10,847 cases. Another 812 outbreaks totaling 23,126 cases were traced to multiple-ingredient foods, such as pizza and salads. Dairy products were blamed for 153 outbreaks totaling 5,156 cases. Almost a third of the outbreaks (32%) were linked to unpasteurized items. The report says CDC has made several improvements in its foodborne disease surveillance and reporting programs in recent years but needs to do more. The agency "should mandate reporting by states, provide real-time reporting of outbreaks, and organize outbreaks by food hazard [rather than by pathogen] to increase the utility of its information," CSPI asserts. (CIDRAP 12/1/05 http://www.cidrap.umn.edu/cidrap )
3. Notifications
World AIDS Day --- December 1, 2005
Dec 1 will mark the 18th observance of World AIDS Day. Begun in 1988, this annual worldwide event was established to increase awareness and education regarding HIV infection and AIDS. The 2005 World AIDS Day theme in the US, "Action Makes a Difference," addresses the importance of prevention, testing, treatment, and care programs for persons at risk for or living with HIV/AIDS. At the end of 2003, more than 1 million persons were estimated to be living in the US with HIV infection. Approximately one fourth of these persons were believed to be unaware of their infections underscoring the need for increased efforts to reach populations at-risk with HIV testing and prevention services. Recent data from 33 states indicate that HIV/AIDS diagnoses continue to disproportionately impact non-Hispanic blacks and men who have sex with men regardless of race. For more information about World AIDS Day: http://www.worldaidscampaign.info ; for more regarding other U.S. HIV/AIDS observances: http://www.omhrc.gov/hivaidsobservances/index.html. Information on AIDS is available from the Joint UN Program on AIDS at http://www.unaids.org. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5446a1.htm (MMWR November 25, 2005 / 54(46);1177)
Conclusions and Recommendations of the Advisory Committee on Poliomyelitis Eradication--Geneva, Switzerland, October 2005
Licensure of a Combined Live Attenuated Measles, Mumps, Rubella, and Varicella Vaccine
4. APEC EINet activities
APEC e-Health seminar; Pandemic influenza videoconference
EINet presented an update of their work and next steps at the e-Health Seminar in Seoul, Korea, 14 Nov 2005, part of the APEC meetings in Korea. EINet is preparing for a major video conference on pandemic influenza preparedness 19 Jan 2006. The goal of this �virtual symposium� is to promote regional information sharing and collaboration to enhance biopreparedness against pandemic influenza. In order to improve preparedness regionally, it is vital to understand how each economy is undertaking preparedness and response planning. South Korea has generously offered EINet their video of their preparedness exercise drill. The video can be found in our �About EINet� section, under Library: http://depts.washington.edu/einet/about.html?a=about&sub=docs.
5. To Receive EINet Newsbriefs
APEC EINet email list
The APEC EINet email list was established to enhance collaboration among health, commerce, and policy professionals concerned with emerging infections in APEC member economies. Subscribers are encouraged to share their material with colleagues in the Asia-Pacific Rim. To subscribe, go to: http://depts.washington.edu/einet/?a=subscribe or contact email@example.com. Further information about APEC EINet is available at http://depts.washington.edu/einet/.


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March 2005 - Then Chancellor Carnesale commits $20 million over five years to deepen UCLA's impact on the field of stem cell and regenerative medicine.
August 9, 2001 - President Bush limits federal funding for stem cell research to the existing 21 human embryonic stem cell lines and prohibits funding for research on stem cell lines created after August 9, 2001.
October 2006 - The Stem Cell Institute faculty members are Amander Clark formerly of UCSF; William Lowry formerly of Rockefeller University; Hanna Mikkola formerly of Harvard; Kathrin Plath, formerly of the Whitehead Institute at MIT; April Pyle formerly of Johns Hopkins University.
June 2007 - The multi-user laboratory space equipped with four tissue culture areas makes possible human embryonic stem cell research that is either not allowed due to current federal funding restrictions or not technically feasible in individual research laboratories.
November 2004 - Proposition 71, establishes the California Institute for Regenerative Medicine (CIRM) and authorizes the issuance of $3 billion in state general obligation bonds to provide funding for stem cell research and facilities in California.
February 2008 - Led by Kathrin Plath and William Lowry researchers use genetic alteration to turn back the clock on human skin cells and create cells that are nearly identical to human embryonic stem cells, which have the ability to become every cell type found in the human body. Previously, only two teams of scientists from Kyoto University and the University of Wisconsin-Madison had reported the creation of iPS cells from human cells.
May 2008 - UCLA officials create space that includes research labs and core facilities to accommodate both senior and junior faculty members interested in a wide range of stem cell research areas.
March 9, 2009 - President Obama signs an executive order to lift the restriction imposed by President Bush wherein funding is prohibited for human embryonic stem cell research on cell lines created after August 9, 2001.
May 2009 - Initial funding for the JCTM comes from a two year, $5 million gift from The Eli and Edythe Broad Foundation to CalTech. The JCTM advances experimental research into clinical applications, including the diagnosis and therapy of diseases such as cancer.
July 2009 - The STM Program awards young clinician scientists the extraordinary opportunity to pursue translational endeavors that will drive their basic scientific discoveries to clinical application and ultimately impact patient care.
October 2009 - Three BSCRC scientists, Drs. Donald Kohn, Irvin Chen, and Dennis Slamon, are awarded CIRM grants totaling $49.2 million to take leading-edge stem cell science from the laboratory and translate it into new therapies.
May 2010 - hESC lines, UCLA 1, 2, and 3, derived by Drs. Amander Clark and Rachel Kim are available for use in federally funded research projects, increasing the diversity of cell lines available for study. UCLA is one of only nine institutions in the world with stem cell lines admitted to the NIH registry.
photo credit: Human Embryonic Stem Cells PLoS Biology via Wikimedia Commons
October 2010 - The state stem cell agency today awarded four grants totaling $12 million to researchers with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA to translate basic science into new and more effective therapies to regenerate bone and treat deadly brain cancers, spinal cord injuries and cornea disorders that result in blindness.
June 2010 - Using stem cells to replace or restore tissues lost to injury or disease represents an area of great promise in regenerative medicine. However, immune rejection of stem cell transplants remains a challenge to translating science from the lab into the clinic. Gay Crooks will use her grant funding to develop "tolerant" T cells, cells that have been engineered to not react against, or reject, transplanted cells.
November 1998 - James Thomson (University of Wisconsin) successfully removes cells from the inner cell mass of embryos and develops the first human embryonic stem cell lines; scientists still utilize these lines to further their research.
September 2007 - The Institute is renamed Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. This generous gift enables UCLA to purchase specialized, high-tech laboratory equipment, support faculty recruitment through research grants and continue its leadership in cutting-edge, multidisciplinary scientific and medical research.
October 2010- The CIRM - BSCRC Laboratory is a state-of-the-art stem cell research facility that fosters scientific collaboration across disciplines in the pursuit of advancing stem cell and regenerative medicine. The CIRM-BSCRC Laboratory is housed in the Terasaki Life Sciences Building. In May 2010, UCLA professor emeritus of surgery and pioneer in organ transplant medicine, Dr. Paul Terasaki, donated $50 million to UCLA Life Sciences; the building was named in recognition of his visionary philanthropy.
January 2011 - Three BSCRC researchers, Dr. Richard Gatti, a professor of pathology and laboratory medicine, Dr. Thomas Carmichael, an associate professor of neurology, and Dr. Martin Martin a professor of pediatrics and gastroenterology, were awarded more than $5.3 million in state grants to develop innovative tools and technologies that will help overcome the technical hurdles in advancing basic, translational and clinical stem cell research.
May 2011 - Six BSCRC researchers, Drs. Gay Crooks, Shuo Lin, William Lowry, W. Robb MacLellan, Kathrin Plath, and Yi Sun were awarded more than $8 million in grants from the state stem cell agency on May 3 to investigate basic mechanisms underlying stem cell biology and differentiation. The studies supported by these awards will form the foundation for future translational and clinical advances, enabling the realization of the full potential of human stem cells and reprogrammed induced pluripotent stem cells for therapies and as tools for biomedical innovation.
September 2011 - Two BSCRC scientists have received prestigious awards from the National Institutes of Health (NIH) recognizing their leading-edge, innovative research. Researchers Utpal Banerjee, the Irving and Jean Stone Professor and chairman of the Molecular, Cell and Developmental Biology Department and Heather Christofk, an assistant professor of molecular and medical pharmacology, received the NIH Pioneer Award and New Innovator Award, respectively. Banerjee was awarded $2.5 million over five years, Christofk will receive $1.5 million over five years
June 2007 - Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body. The implications for disease treatment could be staggering. Reprogramming adult stem cells into embryonic stem cells could generate a potentially limitless source of immune-compatible cells for tissue engineering and transplantation medicine.
November 29, 2011 - Dr. Owen Witte, founding director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and a renowned cancer researcher, was selected today by President Barack Obama to serve on the President's Cancer Panel, which monitors the development and execution of the National Cancer Program. The members of the panel are selected based on their training, experience and background as exceptionally qualified to appraise the National Cancer Program.
February 10, 2012 - The Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA received a $1 million gift today for its annual stem cell symposium that draws top scientists from around the world. The Bloomfield Family Foundation, headed by Margaret "Peggy" Bloomfield of Pacific Palisades, made the gift. Bloomfield is a long-time supporter of the Broad Stem Cell Research Center. The gift was announced by Witte Friday morning at the start of the eighth annual stem cell symposium, "Stem Cells and Cancer: Shared Paths, Different Destinations"
July 26, 2012 - A team of scientists led by Dr. Antoni Ribas, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and a professor of medicine, were awarded a $20 million grant today to take leading-edge stem cell science from the laboratory and translate it into a new treatment for metastatic melanoma, a deadly form of skin cancer.
December 14, 2012 - Two cardiology investigators from the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Drs. Reza Ardehali and Ali Nsair, received grants totaling over $6 million from CIRM, the state stem cell agency. They will use their clinical and scientific training to conduct leading-edge research on the developmental and molecular biology of stem cells to advance regenerative medicine for heart disease. The studies supported by these awards will help form the foundation for translational and clinical advances, enabling realization of the potential of human stem cells for therapies and as tools for biomedical innovation.
Researchers at UCLA's Jules Stein Eye Institute and colleagues who successfully transplanted specialized retinal cells derived from human embryonic stem cells into the eyes of two legally blind patients report that the transplants appear safe and that both patients have experienced modest improvement in their vision. The patients are part of two separate clinical trials, each of which will eventually include 12 patients. The trials will aim to determine the safety of this particular use of stem cell therapy, as well as the patients' ability to tolerate the treatment. UCLA Newsroom Full Story
More Information on the Clinical Trial at UCLA
Photo: UCLA's Dr. Steven Schwartz performs stem cell transplant. (Source: UCLA Newsroom)
February 20, 2013 - Five outstanding young professors from UCLA are among 126 scientists and scholars to receive Sloan Research Fellowships from the Alfred P. Sloan Foundation. Two of the five UCLA recipients, Drs. Jason Ernst and Yi Xing, are members of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Center. Ernst conducts research in computational biology and bioinformatics, developing and applying computational methods to better analyze and model high-throughput experimental data, while Xing's laboratory studies gene regulation at the RNA level using computational and experimental approaches and develop novel methods for the analysis of massive genomic data. The fellowships are awarded to exceptional young researchers who "represent the very best that science has to offer" and are "the next generation of leaders in the natural sciences, economics, and mathematics," according to the New York–based foundation.
March 28, 2013 - Dr. Brigitte Gomperts,, a member of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and associate professor of pediatric hematology/oncology, received a Tissue Collection for Disease Modeling grant of over $900,000 from the California Institute of Regenerative Medicine (CIRM). The award will support the collection of blood from patients with a progressive and potentially fatal lung disease, idiopathic pulmonary fibrosis (IPF), and the blood will be used to create induced pluripotent stem cells (iPSC). iPSC can become any cell in the body, similar to embryonic stem cells, but instead of coming from human embryos, scientists induce skin or blood cells back to a pluripotent state in the laboratory. To date, UCLA and its stem cell scientists have received 60 grants from CIRM totaling more than $189 million.
August 28, 2013 - Four prominent UCLA stem cell researchers have received Early Translational research awards totaling approximately $13 million from the California Institute for Regenerative Medicine (CIRM) the state stem cell agency. The UCLA researchers received four of the 12 total awards; no other applicant institution received more than one award. The awardees are Dr. Jerome Zack professor of medicine and microbiology, immunology and molecular genetics; Dr. Robert Reiter, Bing professor of urologic research; Dr. Donald Kohn professor of pediatrics and microbiology, immunology and molecular genetics in the life sciences; and Dr. Gerald Lipshutz, associate professor-in-residence of surgery, urology and medicine. The grants are part of CIRM's Early Translational Research Initiative, which aims to fund and advance promising, innovative discoveries using stem cells. In this "early translation" phase, scientists are expected to do research that will result in the development of drugs or cellular therapies to be used in FDA-approved clinical trials; translating discoveries from the laboratory to the clinic as quickly as possible.
January 29, 2014 - Recipients of the four Basic Biology V awards from the state stem cell agency, CIRM, included Dr. Lili Yang,who received $614,400 for her project to develop a novel system for studying how stem cells become rare immune cells; Dr. Denis Evseenko,who received $1,146,468 for his project to identify the elements of the biological niche in which stem cells grow most efficiently into articular cartilage cells; Dr. Thomas Otis and Dr. Ben Novitch, who received $1,148,758 for their project using new light-based optigenetic techniques to study the communication between nerve and muscle cells in spinal muscular atrophy, an inherited degenerative neuromuscular disease in children; and Dr. Samantha Butler who received $598,367 for her project on discovering which molecular elements drive stem cells to become the neurons, or nerve cells in charge of our sense of touch.
December 12, 2013 - Scientists from UCLA's Broad Stem Cell Research Center are bringing stem cell science funded by the California Institute of Regenerative Medicine (CIRM), the state stem cell agency, directly to patients in two exciting new clinical trials scheduled to begin in early 2014. The recipients of the Disease Team Therapy Development III awards were Dr. Dennis Slamon and Dr. Zev Wainberg, whose phase I clinical trial will test a new drug that targets cancer stem cells and has been approved to begin enrolling patients in the US and Canada, and Dr. Donald Kohn, whose first-in-human trial is on stem cell gene therapy for sickle cell disease(SCD).This will be the first-in-human testing of stem cell gene therapy for sickle cell disease that allows patients to be their
own bone marrow donors.
May 16, 2014 - UCLA has kicked off its $4.2 billion Centennial Campaign, the largest fundraising effort ever undertaken by a public university. Launched as UCLA counts down to 2019, the 100th anniversary of its founding, the campaign celebrates a century of growth and achievement as a top-tier university and seeks to secure the institution's future as a center for higher education where innovative teaching, groundbreaking research and dedicated service advance the public good. Learn more about giving opportunities for UCLA Broad Stem Cell Research Center's Centennial Campaign and pledge your support today.
May 8, 2014 - The Broad Foundation's $2 million gift to the UCLA Broad Stem Cell Research Center (BSCRC) adds to the 2007 gift of $20 million for which the Center is named. The 2007 gift has supported faculty and research and launched the Innovation Award program, which furthers cutting-edge research at the Center by giving UCLA stem cell scientists "seed funding" for their research projects. The new gift will enable the continuation of the Innovation Award program, which has yielded a 10-to-1 return on investment with grantees securing additional funding from other agencies, including the National Institutes of Health and more than $200 million in total grants from the California Institute for Regenerative Medicine, the state's stem cell agency.
April 14, 2014 - Dr. Owen Witte, director of UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is a 2014 inductee into the American Association for Cancer Research (AACR) Academy. The Academy was created to recognize and honor distinguished scientists whose important research has significantly advanced the fight against cancer. Dr. Witte's research laid the foundation for the development of the drug Imatinib (Gleevec®), the first targeted therapy for chronic myeloid leukemia.
May 29, 2014 Dr. John Chute has been awarded a Research Leadership Award of $5.1 million from CIRM, the state's stem cell agency. This is intended to bolster California's efforts in stem cell research and further its mission to advance novel treatments and cures into medical practice. Dr. Chute's groundbreaking research focuses on the study of hematopoietic stem cells (HSC, the cells that become blood cells) and how they grow. Specifically, he and his colleagues are defining the mechanisms through which the bone marrow microenvironment cells regulate HSC self-renewal, repair and regeneration. Among his multiple discoveries are two novel proteins that are essential to the growth of blood cells. With this knowledge, Dr. Chute and his team can also understand how leukemia stem cells use the same mechanisms in their growth, and target those growth factors with cellular therapies. Dr. Chute is the only clinician scientist to receive a CIRM Leadership Award.
March 2, 2015 - Dr. Donald Kohn and colleagues show that a novel stem cell gene therapy method could one day provide a one-time, lasting treatment for the most common inherited blood disorder in the United States – sickle cell disease. The stem cell research published today in the journal Blood, outlines a method that corrects the mutated gene that causes sickle cell disease and shows, for the first time, the gene correction method leads to the production of normal red blood cells that do not sickle. The fascinating gene correction technique used specially engineered enzymes, called zinc-finger nucleases, to 'cut' out the mutated genetic code and replace it with a corrected version that repairs the beta-globin mutation.
Read Full News Story and Access Related Links
April 7, 2015 -The American Association for Cancer Research (AACR) announced today that Dr. Owen Witte, the founding director of the Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research at UCLA, will receive the prestigious G.H.A. Clowes Memorial Award. Witte is being recognized for his many contributions to the understanding of human leukemias, immune disorders and the stem cells involved in the formation of epithelial cancers (cancers of the lining of glands or organs such as the prostate or ovaries). His pioneering work laid the foundation for several approved targeted cancer therapies, transforming the lives of patients with Philadelphia chromosome-positive leukemias and B-Cell malignancies. Witte's research was key to the development of the drug Imatinib (Gleevec®), the first targeted therapy for chronic myeloid leukemia.
July 23, 2015 - The California Institute for Regenerative Medicine voted unanimously to award UCLA with $7.4 million to lead a phase I/II clinical trial for X-linked chronic granulomatous disease, an immunodeficiency disorder commonly referred to as X-linked CGD. The trial, which will use stem cell gene therapy to correct the genetic defect associated with the disorder, is led by renowned stem cell researcher and UCLA Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research member, Dr. Donald Kohn.
Read Full News Story and Access Related Links
October 23, 2014 In a first-of-its-kind collaboration, the University of California, Los Angeles, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and University of California, Irvine Sue & Bill Gross Stem Cell Research Center received a five year $8M grant from the California Institute of Regenerative Medicine (CIRM), the state's stem cell agency, to establish a CIRM Alpha Stem Cell Clinic "center of excellence" to conduct clinical trials for investigational stem cell therapies and provide critical resources and expertise in clinical research.
Read Full News Story and Access Related Links


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Shinola Henry Ford Pocket Watch
We already love Shinola's amazing handcrafted timepieces. Their upcoming 49mm stainless steel pocket watch that pays tribute to automaker Henry Ford. Limited to 1,000 pieces, sign up now to be notified.
We already love Shinola's amazing handcrafted timepieces. Their upcoming 49mm stainless steel pocket watch that pays tribute to automaker Henry Ford. Limited to 1,000 pieces, sign up now to be notified.
Apple's smartwatch offers swappable faces, notifications, Siri, messaging, fitness tracking, maps, weather, calendar, photos, NFC payments, and 3rd party apps. Its UI leverages the crown so you don't block the screen. Out early 2015.
Mattew Humphries handcrafts military and diver's watches based on the legendary Seiko 5 series, which brought durable mechanical watches to an affordable price point. Matthew also accepts bespoke orders.
The racing-inspired watchmaker Autodromo taps into "Italian sports berlinettas of the late 1950s and early 1960s" for its latest line of watches. The Stradale has a multilayered dial and a quilted leather strap. Available in 3 colors.
Blending natural materials with modern design, this wooden analog watch tells time using dots which show through tiny round windows. Has a stainless steel back and a premium leather strap with either a maple or walnut face.
Brathwait uses the same materials and factories used by luxury watch makers. But because they have only an online shop and skip the middlemen – agents, resellers etc. – they can pass on their savings to you.
Has a Swiss movement, a sapphire glass, a stainless steel case and is waterproof up to 330ft. It has dual time zone, alarm, chronograph and programmable compass functions, and a video that will make your balls grow moustaches.
Mijlo's Everyday Watch has two watches and five straps – three leather, one rubber and one canvas strap – giving you 10 combinations to choose from. The straps can be swapped without using tools. It also comes with a rollable felt case.
Limited to just 59 pieces, Linde Werdelin's latest timepiece is truly stunning, crafted from a custom alloy with a titanium crown, it has a 23-jewel movement and a five-layer dial with a luminescent moon phase indicator.
German watchmaker NOMOS Glashütte lets us get up close and personal with the process behind the creation of their intricate and luxurious mechanical timepieces, which are still largely made by hand.
MeisterSinger's elegant timepieces offer a Swiss ETA movement which tell time using a jump hour disc and a single hand for minutes. Built from stainless steel with an open casing back, 5-bar water resistance, and a sapphire glass crystal.
With its dramatic 46mm square stainless steel case, the Uhr-Kraft HeliCop features an automatic movement, date and sweep-second functions and is water-resistant to 100 meters, and is sure to be a conversation starter.
Built in Detroit, the Runwell Contrast Chrono looks amazing with its 47mm PVD stainless case and black rubber strap. Offers stopwatch, sweep second and date functions. Each movement is hand-assembled from Swiss components.
An elegant watch and fitness tracker. It tracks calories burned and distance covered when you walk, run or swim. Made of stainless steel and sapphire glass and comes with a leather and a plastic strap. Available this Fall for $390.
This rugged analog watch is the ultimate adventurer's timepiece, concealing a compass, can opener, firestarter, whistle, signal mirror, magnifying glass, fishing line, hooks, and cutting tool inside. It's also got a built-in LED flashlight.
Nixon's groovy surf watch displays 48-hour tide forecast information for 270 beaches on a sharp hi-res display. Water resistant to 100 meters, and available in marbled camo, black smoke or marbled multi-color silicone bands.
Kairos mechanical watches also have smartwatch functionality. A transparent touchscreen on top of the watch face displays notifications and other features. They will run Android Wear or Kairos' own OS. More here.
TokyoFlash's handsome limited-edition watches combine wood cases and bands with retrofuturist LED displays. Despite looking cryptic, the digits are actually quite easy to read. Available in several LED colors and dark or light wood.
Modify applies their mix-and-match design aesthetic to Major League Baseball, offering team logo watches for all 30 teams. Since the faces and straps are interchangeable, you can easily switch teams if yours starts to suck.
A 44mm chronograph inspired by racing stopwatches – in fact it looks like a stopwatch that grew straps. The Corsa is water resistant up to 10atm. It's available in a variety of colorways, with a matching leather or NATO strap.
Should we go so far as to say second and minute hands are for plebes? Maybe not, but we must admit this unique single hand watch from Komono is pretty darn cool. And frankly, it doesn't get more minimal than this.
The Spacemaster X-33 sports a hybrid analog/digital face, with dual time-zone, alarm, calendar, and stopwatch and flight logging functions. Its case is made from titanium, with a black rubber, leather or titanium strap.
While its black on black face might not be the most legible we've ever seen, we're so taken by its contrasting red and black plaid fabric band that we're willing to give this one a win despite its form over function design approach.
To arrive at the design of its B-Rocket watches, B & R first designed a custom aviation-influenced Harley-Davidson motorcycle which served as inspiration for the watch faces. Seems like a roundabout route, but both look great.
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Interstate 35 southbound at Lamar Avenue was reduced to one lane Thursday evening after a small box truck rolled over.
The Kansas City Kansas Police Department and Kansas Highway Patrol responded to the crash.
No one was injured in the crash, according to KHP dispatch.
The crash happened shortly before 8 p.m.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Sister Act
The charm of commercial expansion has made media houses forget their editorial thrust.
This September has provided us with some moments for reflecting on the sister concerns (or you may call it allied activities) of media houses. To be precise, two such moments.
First, on September 20th, the fortnightly newsmagazine from The Hindu stable, the 28-year-old Frontline, was relaunched. The relaunched magazine has done a sisterly publication act which is vintage Hindu. It represents the elements of continuity and change that one has been noticing in the great media conglomerate run from the Kasturi Buildings. Even the relaunch event at Habitat Centre (Delhi), attended by Vice President Hamid Ansari and historian Romila Thapar (along with Hindu's top brass), reflected those elements, as did Hindu's other publications like the book-format issues of Annual Survey of Indian Agriculture, Industry and Environment and the weekly, Sportstar. The jarring note in this Hindu symphony is an editorial disaster (not necessarily a market failure) called NDTV-Hindu (Chennai's city-specific news and entertainment channel).
Second, this September also marks the five-year existence of NDTV's lifestyle channel, NDTV Good Times. As the catch phrase in the branding (Good Times) shows, the channel was launched in 2007 as a joint venture between NDTV and Vijay Mallya's UB group. In ways that the sister concerns of media houses can reveal, the concept and orientation of the channel tells you where NDTV's heart is. In times, when news channels have no air-time for addressing the livelihood issues in a country with one of the poorest HDI indicators, one of the biggest media companies in the country went ahead with a "lifestyle" channel. What came tumbling out was never a skeleton in the cupboard. You knew it all along – the channel targets a section of the population which has the purchasing power to keep advertisers interested (the urban rich and even the aspirational urban middle class). NDTV's news channel has the same core viewership.
The list of the shows aired on NDTV Good Times resembles a template of urban consumerism blended with the fetish for the "exotic". In such templates, people are prosperous enough to have fun trips to explore the "exotic" and patronising enough to have a slice of "Indian" life. When the Indian with purchasing power and consuming zeal meets the need for an exotic feel, you have these shows – Big Fat Indian Wedding, Gadget Guru, Gourmet Central, Highway On My Plate, I am Too Sexy for My Shoes, Kingfisher Calendar Model Hunt, Royal Reservation, Heavy Petting, Chakle India, etc. The names are suggestive enough, and the global templates for "consuming viewers" are not different either.
For instance, Fox Traveller (owned by News Corporation's – Fox International Channels) carries the stamp of the market as evidently as the empire's media "outlets" (that's the word that may please their branding managers). So is it surprising that one of its India-specific shows goes by the name – What's with Indian Men?
The allied channels, publications or even supplements tell you a thing or two about the editorial thrust (in many cases, lack of that thrust) of a media house. After reading The Times of India, if you glance at its city supplements, Delhi Times/ Bombay Times etc (for many it's the other way round), you can spot the umbilical cord quite easily. So is the case when you realise that Filmfare and Femina also come from the same stable. And isn't there something very The Times Of India about how Femina used its promotional catch phrase – "for the woman of substance"? So banking on the aspirational frenzy in a section, the magazine had thought that the essence of Indian feminity would be dictated by Dr DN Road in Mumbai, whose idea of the heat and dust of average Indian living doesn't go beyond that of a starry-eyed wannabe. But, does TOI end up doing anything else in its daily engagements with readers?
Sometimes, the allied publications of some media houses carve a niche for themselves. In this context, you can't forget remembering Literary and Higher Education supplements of The Times, published from London. And there has been speculation that The Guardian is also coming up with new supplements on those lines. If that's true, you can look forward to some more stimulating stuff from the publishers of The Guardian. In the media cacophony, the need for such long form of reflections is being felt and some media houses are responding to it. At Frontline's relaunch function, Vice President Hamid Ansari perceptively remarked: "In today's age, the audio-visual media has emerged as a dominant medium for quenching the thirst of the target audience for real time news on current affairs, culture and entertainment. Despite this, there remains a real and popular demand for serious publications on topical issues which cannot be substituted by the "breaking news" culture and short-attention span snippets in the domain of the electronic media."
It's a sign of our times that diversification for media houses is echoing the tunes of corporate diversification. But, in the process, such sisterly avatars are exposing the faultlines that have become entrenched in media operations. High time for some introspective parenting in media houses. Such sisters need to be reined in. Or they need a different template.
All our articles are run through a software to avoid the possibility of unattributed work finding its way into Newslaundry.


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Tonight's Concert Picks: Trails and Ways at Kung Fu Necktie, John Mellencamp at Merriam Theater, Hemming at Milkboy
Pop group Trails and Ways have emerged with their first full-length, Pathology, this month, and tonight they headline Kung Fu Necktie. Their music resembles Beach Fossils by way of Passion Pit — certainly the type of sound to spend your summer evening enjoying. Watch video for "Mtn Tune" below, and get tickets to their 21+ show here. Continue reading →


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Throughout the years we have received positive comments on our cakes from many well-known persons.
Narcai David, Ann Landers, The Chicago Tribune, and Carmel Magazine have all published glowing reviews.
""When you forwarded that article describing how the monks of the New Camaldoli Hermitage are coping with their financial crisis, you claimed that their fruitcake is the best fruitcake in the world. I thought you were exaggerating. Not now! This stuff is preternaturally delectable! It's not just the best fruitcake in the world, it's the best fruitcake in the known universe. I love the way it sticks to everything, leaving brandy prints on breadboards, plates, fingers, clothing, you name it. And surprisingly, the list of ingredients shows that this celestial cake made by meditative Christians is better nutritionally too, compared to the vast majority of desserts."
" Vance Aandahl
"I shared it with my colleagues at a station meeting.
At first they were hesitant but after they got a whiff of brandy,
they were eating out of my hand :)" Becca
"I don't even like fruitcake, and avoid it at all costs. But I was given a free sample, and I'll probably stop only when the samples run out." E. B.
"Your gourmet fruitcake tastes just like my mother in England used to make - delicious!" L. H. UK
"Best I ever tasted." L.A.R. Port Huron, MI
"Delicious! A favorite! You are going to love it!" Narsai David, CBS food critic
"Last year I was given a fruitcake . . . most delicious our family ever tasted - far better than I've ever made (and I thought they were excellent)." Margaret H. , Palm Springs, CA
"Thank you for your product It's wonderful." Anatol B., CA
That old story about the same fruitcake getting passed around every holiday season just isn't true, at least not for our brandy-dipped fruitcakes and date-nut cakes. These cakes disappear quickly, which is why we still make the same, full sized fruitcakes and date-nut cakes we always have, from the same decades old recipe.
Our brandy-dipped fruitcakes and date-nut cakes have stood the test of time, standing out even among other monastic cakes. Moist, delicious, well reviewed by food experts, fruitcake lovers, and even fruitcake skeptics! Half the secret is the brandy dipping, but that's really no secret. Our carefully baked fruitcakes and date-nut cakes are aged at least 3 months in a temperature controlled environment.
Our Hermitage fruitcakes are made with cherries, pineapples, California raisins, walnuts, dates, and Georgia pecans. Our date-nut cakes are made with choice California dates and fresh walnuts, which are blended with a variety of spices. Cakes are dipped in grape brandy and aged for 3 to 6 months. For holidays -or any special occasion- send a cake to everyone on your gift list with one simple billing. A special message that you create is included with every gift order.
Dec. 19th - San Francisco Bay Area
Dec. 18th - California outside San Francisco Bay Area
Dec. 12th - Outside California
Dec. 10th - Eastern States
1 lb Fruitcakes coming back soon!
Your first gift order is empty.


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What materials did you use?
4 ply yarn, worst weight yarn, acrylic yarn
3.75 - 4.00 mm Hook
What are you most proud of?
It's functional !
What advice would you give someone starting this project?
Add puff color to the sole to make them non-slippery :-)
I love these I've got to make them for my G BBy she's 3!!
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Sam Worthington Goes Southern in the 'Texas Killing Fields' Trailer
The Texas Killing Fields trailer recreates the true story of the desert wasteland outside Texas City, wherein over sixty murder victims have been discovered over the past forty years. Sam Worthington and Chloe Moretz lead a cast in what seems to be a somewhat disjointed and flat adaptation of the real-life horror story.
The film, which will be playing at the 2011 Venice Film Festival and opens October 7. Ami Canaan Mann (Heat) directs a cast including Stephen Graham (who will be returning as Al Capone in the upcoming season of Boardwalk Empire), Jeffrey Dean Morgan (Watchmen), Jessica Chastain (The Help) and Jason Clarke (Public Enemies).
Source: Indiewire


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An associate of Mexico's infamous Sinaloa drug cartel who became an informant for city and federal authorities helped derail a New York-to-Philadelphia cocaine pipeline, the Philadelphia District Attorney's Office said Wednesday.
The 17 arrests announced Wednesday followed a three-month sting operation involving an alleged ring that was trafficking cocaine from New York City to Philadelphia, using secret compartments in vehicles.
On May 13 and 20, 10 kilograms (22 pounds) and 18 kilograms (40 pounds) of cocaine were seized from vehicles delivering the drugs to Philadelphia, officials said. Lisette E. Pichardo and Juan D. Rivera of San Juan, Puerto Rico, were arrested May 13.


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twitter feedback
Unfortunately, we are worse than Greece, as we are an uneducated society that is politically divided.
- princess bijous
I agree. I may not work directly with closing books, but the evidence is plain to see. Food is harder to buy or go to work.
- Rhythm Goddess
That's what you get for putting that horrible PNP government back into power. Since 1988, they have mashed up my lovely country.
- Steafan Russell
Distraction to make us spend time complaining and arguing instead of taking the necessary actions to improve OUR economy.
- D_Anne
That's so sad. So little goes to help the people and so much goes to rich banks.
- David Michael
Actually, Greece is the Jamaica of Europe.
- Sharifa Wright
But what to do? So depressing!
- milcar Tafawa Lewis
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Gregory Davis
TitleVice President, NFP Lincoln Benefits Group
Gregory Davis is vice president of NFP Lincoln Benefits Group, a provider of comprehensive financial planning and employee benefits administration located in Fort Washington, PA. His mission is to educate his clients about the fundamental concepts of finance and risk management so that they will be in position to not only live comfortably but also to take advantage of the wealth-building opportunities presently available in today's economic market. To that end, he dedicates hours of his free time conducting financial literacy seminars for community groups, schools and church groups.
Mr. Davis has a B.S. in commerce and engineering and an M.B.A. in finance, both from Drexel University. In addition, he has earned the most prestigious designations in the financial services industry. They include: Certified Financial Planner (CFP); Chartered Life Underwriter (CLU); Certified Employee Benefits Specialist (CEBS) and Chartered Financial Consultant (ChFC). He is a licensed insurance agent, a Registered Investment Advisor and a licensed Securities Series 6 and 7 representative in Pennsylvania, New Jersey and Delaware.
He serves on the Boards of the AIDS Law Project, Maternity Care Coalition, Allens Lane Art Center, CeaseFirePA and Wordsworth Academy. He is a member of the DNC National Finance Committee.
Mr. Davis resides in the Mount Airy section of Philadelphia and is the proud father of two children, Alisha and Gregory.


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Failed movie magic: Five films to avoid at theaters this week
Photo: Nicole Rivelli/Lionsgate Pictures
PEEPLES -- This broad comedy in the mold of "Meet the Parents" has scattered laughs and a pleasant supporting cast but overall isn't very memorable.
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