text:
The Society will appear at the Repertory East Playhouse tonight, Friday, May 14, at 8 p.m. Family-friendly improvised music, comedy, scenes, the works - if you've seen "Whose Line is it Anyway?" you have an idea of what kind of hilarious, energetic comedy that team improv can be.
The Society boasts a cast of professional actors, writers, comedians and "idiots" who have performed at colleges and comedy clubs across the country.
Kirby Heyborne, a founding member of the group and Santa Clarita resident, said, "We have been performing everywhere together now for almost a decade. And as the old adage goes, there really is no place like home. We love the Santa Clarita audience."
Join The Society for an evening of hilarity and laughs tonight at The Repertory East Playhouse, 24266 Main St., Newhall, CA 91321. For tickets ($10) and information call (661) 288-0000. Tickets are also available online at www.repeastplayhouse.org.


text:
FAM SERV 1010 Human Identity & Relationships -- 3 unit(s)
Use of social science theory and research to understand psycho-socio-cultural influences in the development of identity and interpersonal relationships. Emphasizes application of current research and theory to facilitate positive individual growth and committed intimate relationships.
Term: Fall 2014
Start/End Date: Aug 25, 2014 - Dec 12, 2014
Meeting Time: Arranged
Location (Facility ID): eLearning
Instruction Mode: Online
William Henninger, Assistant Professor
Class Section: 07
Class Nbr: 35508
If two numbers are listed, undergraduate level class number is listed first, graduate level class number is listed second.
Course Notes:
Instructions for accessing course materials will be sent to enrolled students' email accounts prior to the start of the course.
To enroll:
Click here to enroll through the Student Center in MyUNIverse
For more information:
Monica Johnson, Continuing and Distance Education
Phone: 319-273-2504
Email: email@example.com

subset: commoncrawl


text:
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Sarah Jessica Parker's Yellow Blazer: Yay or Nay
Amanda Hasaka
| August 31, 2011 - 11:25 am
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text:
The Wall Street Journal, in its article "The Big Doubt Over Facebook", states Facebook has built a $3 billion a year advertising business. So, what are advertisers getting for their money? With about 900 million users, you could make an assumption that an ad on Facebook could boost sales. However, here at Marketsmith, we don't like to make assumptions; we like the hard facts. How many consumers clicked on our ad? How many consumers bought something after clicking on our ad? What's the ROI?
Michael Sprague, VP of Marketing at Kia Motors Corp.'s North America said, "What are we getting for our dollars?" Unlike Google and Yahoo, who sell traditional display and search ads on their sites from which advertisers can directly track the return on ads, Facebook does not permit third-party surveys on its site or allow ads to be tagged with "cookies".
To address marketers' concerns, last year Facebook started working with research firms comScore Inc. and Nielsen Co. to offer tools for brands to track Facebook campaigns. Nielsen attempts to match ad exposure to product sales. But it is not necessarily possible to measure the direct effect of Facebook advertising on purchases, particularly for high end products for which the decision-process may be long and include intangibles such as emotional reactions, word of mouth, seeing what your family and friends like, etc.
WSJ quotes a Ford spokesman, Charles Zinkowski, who noted that "more than 20% of the company's digital media spend is on Facebook", but declined to be specific. He also shared "by using Facebook ads instead of Super Bowl ads in marketing its 2011 Explorer, shopping activity for the Explorer jumped 104% versus the average shopping lift of 14% following a Super Bowl ad." So even though we cannot see the same granular data provided elsewhere, there are methods of drilling down to measure the effect of Facebook advertising which we at Marketsmith work to identify for our clients in order to evaluate Facebook as a worthwhile investment of marketing dollars. We do notice advertising value is not the only metric it is difficult to assess on Facebook. Both the WSJ and DealBook comment on determining value with respect to the IPO. Maybe there will be more transparency after Facebook becomes publicly traded and must be accountable to shareholders. We will certainly be watching to see what happens, and ready to respond in order to drive increased marketing ROI for our clients.
Source: Wall Street Journal
Jen Allain
Client Services Associate
Marketsmith, Inc.


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News in "Migration/Immigration"
Page 10 of 16. Return to the Migration/Immigration topic tag page
May 16, 2013 - Publication
Contributing to a Stronger American Democracy: President's Essay
In his annual essay, MacArthur President Robert Gallucci focuses on what MacArthur is doing to help strengthen American democracy. Read More
May 13, 2013 - Publication
Advancing Regional Competitiveness through Collaboration on Migration
The report outlines the powerful demographic, economic, and social forces that are reshaping Mexico and much of Central America and changing longstanding migration dynamics with the United States. Read More
April 21, 2013 - Publication
Assessing Migrant Recruitment and Contracting Abuses
Despite international standards to protect migrant workers, their labor rights are frequently abused, especially if they have immigrated in an irregular fashion. Read More
April 5, 2013 - In The Media
"US Industrial Heartland Weighs Up Immigration Reforms"
From the Financial Times
Read More
Read More
April 2, 2013 - In The Media
"Immigration Reform Expected to Boost Midwest Cities Like Cleveland"
From Cleveland.com
Read More
Read More
March 26, 2013 - Publication
'The Back of the Line': Explaining Immigration Lines, Wait Times, Visa Categories
Contrary to popular belief, there is not one "line" that leads to legal permanent residence in the United States; current immigration law provides multiple paths to permanent residency. Read More
March 12, 2013 - In The Media
"The Fundamentals of Immigration Reform"
From The American Prospect
Read More
Read More
March 8, 2013 - In The Media
"U.S. Immigration Policy's Effect on Midwest Businesses"
From WBEZ Chicago
Read More
Read More
March 7, 2013 - In The Media
"Immigration Reform Crucial to Midwest, Study Finds"
From the Milwaukee Journal Sentinel
Read More
Read More
February 28, 2013 - Publication
Immigration and the Economic Future of the Midwest
The economic future of the Midwest rests, in part, on U.S. immigration policy, according to a report by the Chicago Council on Global Affairs. Read More
February 27, 2013 - Press release
13 Nonprofits Recognized for Exceptional Creativity and Effectiveness, Awarded up to $1.5 Million Each
MacArthur named 13 organizations in five countries as recipients of the MacArthur Award for Creative and Effective Institutions. The Award recognizes exceptional grantees and helps ensure their long-term sustainability. Read More
February 22, 2013 - In The Media
"Former Exelon CEO on Why He Backs Immigration Reform"
From Crain's Chicago Business
Read More
Read More
February 11, 2013 - Publication
A Blueprint for Ending International Labor Recruitment Abuse
Labor rights, migrant rights, and anti-trafficking organizations have come together to raise awareness of immigrant worker abuse and to call on Congress to address their concerns. Read More
February 6, 2013 - Publication
Rethinking the Manufacturing Sector in Mexico and Central America
A report from the Regional Migration Study Group, a highlights the changing needs of the Mexican and Central American manufacturing economy, which currently employs 17 percent of the regional work force. Read More
January 22, 2013 - Publication
Child Migration Issues in Mexico and Central America
A new report explores human rights concerns associated with the growth of youth and child migration at Mexico's southern border with Guatemala. Read More


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To the Editor.—
I read with interest the combined reports of the Selected Cancers Cooperative Study Group.1 These well-designed and executed studies demonstrate a statistically significant increased risk for non-Hodgkin's lymphoma in Vietnam veterans relative to a control cohort. This risk appears to be independent of the use of Agent Orange.1 The cause of this increased risk remains obscure, although the authors present several speculative hypotheses. They note that the veterans may possess some characteristic(s) related to service in Vietnam, such as a viral infection, which could explain the risk. I agree that this is a quite reasonable explanation for the increased risk of non-Hodgkin's lymphoma in these individuals.Southeast Asia could be the home of an as yet undescribed oncogenic retrovirus with a low degree of disease expression after infection. A certain percentage of individuals exposed to the putative agent would be infected, and a much smaller
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text:
An unidentified and unpleasent feeling (or possibly tasting) substance rarely ejaculated from the penis during rectal sex
F*IN' A...that guy's left some nasty corn syrup in my ass for three days...
viết bởi JuMBo SIZED 30 Tháng mười hai, 2007
Trending Now
Can you define these popular missing words?
Top Definition
Something that all food & drinks are made with, among millions of other ingredients.
"Don't believe me? Look at the ingredients of ANY food item."
viết bởi Dave 20 Tháng mười một, 2004


text:
|Two poets laureate to read at Sitting Room
Two of Sonoma County's poets laureate will read their work at the Sitting Room in Penngrove from 2-4 p.m., Saturday, April 12.
They will discuss ways to bring poetry to the people and explore the treasures of the Sitting Room's Jane Flood Poetry Room. Katherine Hastings, the newest laureate, is the founder of WordTemple, the poetry forum now based at the Sebastopol Center for the Arts and broadcast Sundays on KRCB as part of their Literary Series. Hastings' most recent book, "Nighthawks," was recently published by Spuyten Duyvil NYC. Her "Small Change Series" of WordTemple Press has published the anthology "What Redwoods Know — Poems from California State Parks" (all proceeds benefit the State parks).
Well known to Sitting Room regulars, Terry Ehret has been teaching at the Sitting Room for more than a decade. Her award-winning body of work has been published by the poetry collective, Sixteen Rivers Press. From 2004-2006 she served as poet laureate of Sonoma County. "Night Sky Journey," her newest collection of lyric and prose poems, has just been released from Kelly's Cove Press.


text:
Top Definition
noun, middle of nowhere, usually used with a cardinal direction, such as North, South, East, or West. Origin: Ghetto
"Where you at?"
"East Bumblefuck! Ah donknow"
"East Bumblefuck! Ah donknow"
de Anonymous 4 novembre 2002
Trending Now
Can you define these popular missing words?
a place in the middle of nowhere
They sent me out to east bumble-fuck
de www.evilrobotmonkey.com 23 mai 2003
out in the middle of no were , usually used as an expression
What the fuck are u doing over there in bumblefuck land?
de Anonymous 28 mai 2003
the place between philadelphia and pittsburgh
scranton or wilkes-barre is an example of bumblefuck
de DREWDOMZ 7 octobre 2006
the middle of nowhere, otherwise known as East Jesus, Gimby, Good God, etc.
"He lives out in Bumblefuck"
de stuckhere 6 octobre 2003
Bumble Fuck: noun
Meaning: A rural/small town area that few people will ever know, or hear about.
Meaning: A rural/small town area that few people will ever know, or hear about.
I live in the middle of no where.
I live in bumble fuck, Pennsylvania.
I live in bumble fuck, Pennsylvania.
de randy 007 29 mai 2006
bobby goes to college in bumblefuck.
de Lor Skelly 8 septembre 2008


text: Do you have what it takes to retire? Are you afraid that you might outlive your money? Attend this class and find out. This course is designed to provide a clear understanding of three key areas: SOCIAL SECURITY – Are you confused about when to sign up? Most people needlessly leave money on the table. This is especially critical for women. MEDICARE – Understand the total potential cost of healthcare in retirement. What does Medicare cover? What does it not cover? What does it cost? What about out of pocket costs not covered by Medicare or Supplemental Insurance? COMPREHENSIVE RETIREMENT PLANNING – Put it all together, How much can you afford to spend? Essential vs lifestyle expenses, Income sources, Retirement plan distributions, Investing, Risk management, Estate planning. It's fun, intuitive and very informative. Yogi Berra insight, "If you don't know where you're going, you'll end up someplace else." That's absolutely true about retirement. Take the class and get on track for a successful retirement.


text:
Biomaterials (v.28, #31)
Editorial board (IFC).
Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro by Xiaomei Liu; Jung Yul Lim; Henry J. Donahue; Ravi Dhurjati; Andrea M. Mastro; Erwin A. Vogler (4535-4550).
Time-dependent phenotypic response of a model osteoblast cell line (hFOB 1.19, ATCC, and CRL-11372) to substrata with varying surface chemistry and topography is reviewed within the context of extant cell-adhesion theory. Cell-attachment and proliferation kinetics are compared using morphology as a leading indicator of cell phenotype. Expression of (α 2, α 3, α 4, α 5, α v, β 1, and β 3) integrins, vinculin, as well as secretion of osteopontin (OP) and type I collagen (Col I) supplement this visual assessment of hFOB growth. It is concluded that significant cell-adhesion events—contact, attachment, spreading, and proliferation—are similar on all surfaces, independent of substratum surface chemistry/energy. However, this sequence of events is significantly delayed and attenuated on hydrophobic (poorly water-wettable) surfaces exhibiting characteristically low-attachment efficiency and long induction periods before cells engage in an exponential-growth phase. Results suggest that a 'time–cell–substratum–compatibility–superposition principle' is at work wherein similar bioadhesive outcomes can be ultimately achieved on all surface types with varying hydrophilicity, but the time required to arrive at this outcome increases with decreasing cell–substratum–compatibility. Genomic and proteomic tools offer unprecedented opportunity to directly measure changes in the cellular machinery that lead to observed cell responses to different materials. But for the purpose of measuring structure–property relationships that can guide biomaterial development, genomic/proteomic tools should be applied early in the adhesion/spreading process before cells have an opportunity to significantly remodel the cell–substratum interface, effectively erasing cause and effect relationships between cell–substratum–compatibility and substratum properties.This review quantifies relationships among cell phenotype, substratum surface chemistry/energy, topography, and cell–substratum contact time for the model osteoblast cell line hFOB 1.19, revealing that genomic/proteomic tools are most useful in the pursuit of understanding cell adhesion if applied early in the adhesion/spreading process.
Keywords: Cell adhesion; Surface chemistry; Surface energy; Cell–substratum–compatibility; hFOB; Osteoblast;
The potential impact of the preparation rich in growth factors (PRGF) in different medical fields by Eduardo Anitua; Mikel Sánchez; Gorka Orive; Isabel Andía (4551-4560).
Platelet-rich preparations constitute a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and biocompatibility of this approach has stimulated its therapeutic use in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, tissue engineering among others. Here we discuss the important progress that has been accomplished in the field of platelet-rich preparations in the last few years. Some of the most interesting therapeutic applications of this technology are discussed as are some of the limitations, future challenges and directions in the field.
Keywords: Growth factors; Platelets; Regenerative medicine; Tissue repair; Drug delivery; Biomaterials;
The effect of gas plasma modification on platelet and contact phase activation processes by Nicholas P. Rhodes; Darren J. Wilson; Rachel L. Williams (4561-4570).
Medical-grade polytetrafluoroethylene (PTFE), polydimethylsiloxane (PDMS), polyetherurethane (PEU) and ultrahigh molecular weight polyethylene (UHMWPE) were plasma treated with O2, Ar, N2 and NH3. Their surface properties were characterised using X-ray photoelectron spectroscopy (XPS), static secondary ion mass spectroscopy (SSIMS), atomic force microscopy (AFM) and dynamic contact angle (DCA) analysis. Platelet adhesion, aggregation, activation and release of microparticles were determined after contact with whole blood in a cone and plate viscometer. Activation of the coagulation system was quantified in a static environment using a partial thromboplastin time (PTT) assay. The chemical compositions of the untreated surfaces were found to be very similar to those of the bulk material except for PEU, whose surface was comprised almost entirely of soft ether segments. For all materials, the different plasma treatments resulted in moderate etching with the incorporation of functional groups and removal of side groups: defluorination, dehydrogenation, cleavage of methyl side groups and soft segments for PTFE, UHMWPE, PDMS and PEU, respectively. Consequently, plasma treatment resulted in increased wettability in all cases. Blood contact with the virgin materials resulted in activation of platelets and the clotting cascade. Plasma treatment resulted in a significant reduction in platelet adhesion for all materials and all treatments. In the case of PTFE and PEU, the activation status of these cells was also reduced. Plasma treatment of all materials reduced fluid-phase CD62P expression. Platelet aggregate size correlated well with degree of aggregate formation, but many treatments increased the degree of aggregation, as was the case for microparticle shedding. There was no correlation between CD62P expression, aggregate formation and platelet microparticle (PMP) shedding. It is concluded that despite incorporation of the same chemical groups, the pattern of response to blood in vitro is not the same across different polymers.
Keywords: Polymers; Haemocompatibility; Platelet; Microparticle; Coagulation;
Reduced foreign body response at nitric oxide-releasing subcutaneous implants by Evan M. Hetrick; Heather L. Prichard; Bruce Klitzman; Mark H. Schoenfisch (4571-4580).
The tissue response to nitric oxide (NO)-releasing subcutaneous implants is presented. Model implants were created by coating silicone elastomer with diazeniumdiolate-modified xerogel polymers capable of releasing NO. The host tissue response to such implants was evaluated at 1, 3, and 6 weeks and compared to that of uncoated silicone elastomer blanks and xerogel-coated controls incapable of releasing NO. Delivery of NO (∼1.35 μmol/cm2 of implant surface area) reduced foreign body collagen capsule ("scar tissue") thickness by >50% compared to uncoated silicone elastomer after 3 weeks. The chronic inflammatory response at the tissue/implant interface was also reduced by >30% at NO-releasing implants after 3 and 6 weeks. Additionally, CD-31 immunohistochemical staining revealed ∼77% more blood vessels in proximity to NO-releasing implants after 1 week compared to controls. These findings suggest that conferring NO release to subcutaneous implants may promote effective device integration into healthy vascularized tissue, diminish foreign body capsule formation, and improve the performance of indwelling medical devices that require constant mass transport of analytes (e.g., implantable sensors).
Keywords: Foreign body response; Angiogenesis; Inflammatory response; Nitric oxide; Xerogel; Wound healing;
In vitro biological evaluation of high molecular weight hyperbranched polyglycerols by Rajesh Kumar Kainthan; Samuel R. Hester; Elena Levin; Dana V. Devine; Donald Elliott Brooks (4581-4590).
Low molecular weight hyperbranched polyglycerols are highly water soluble and biocompatible polyether polyols, which can be synthesized in a controlled manner with narrow polydispersity. Recently we reported the synthesis and characterization of very high molecular weight (M n up to 700,000) and narrowly polydispersed polyglycerols which could be potentially used as alternatives to high generation dendrimers which are difficult to make. A detailed biocompatibility testing of these polymers conducted in vitro is reported here. The in vitro studies include hemocompatibility testing for effects on coagulation (prothrombin time (PT), activated partial thromboplastin time (APTT), plasma recalcification time (PRT), thrombelastograph parameters (TEG)), complement activation, platelet activation, red blood cell aggregation and cytotoxicity. Results from these studies show that these high molecular weight polyglycerols are highly biocompatible and are potential candidates for various applications in nanobiotechnology and in nanomedicine. Moreover these polymers are thermally and oxidatively stable.
Keywords: Hyperbranched polyglycerol; Biocompatibility; Blood compatibility; Thrombelastograph; Red cell aggregation; Coagulation;
Long-term toxicity of holmium-loaded poly(l-lactic acid) microspheres in rats by Sander W. Zielhuis; J. Frank W. Nijsen; Jan-Henry Seppenwoolde; Chris J.G. Bakker; Gerard C. Krijger; Hub F.J. Dullens; Bernard A. Zonnenberg; Peter P. van Rijk; Wim E. Hennink; Alfred D. van het Schip (4591-4599).
The aim of this study was to get insight into the toxic effects of holmium-166-loaded poly(l-lactic acid) microspheres (Ho-PLLA-MS) which have very interesting features for treatment of liver malignancies. Acute, mid- and long-term effects were studied in healthy Wistar rats by evaluating clinical, biochemical and tissue response. Rats were divided into four treatment groups: sham, decayed neutron-irradiated Ho-PLLA-MS, non-irradiated Ho-PLLA-MS and PLLA-MS. After implantation of the microspheres into the liver of the rats, the animals were monitored (body weight, temperature and liver enzymes) for a period of 14–18 months. Some of the rats that received previously neutron-irradiated Ho-PLLA-MS were periodically scanned with magnetic resonance imaging (MRI) to see if holmium was released from the microspheres. After sacrification, the liver tissue was histologically evaluated. Bone tissue was subjected to neutron-activation analysis in order to examine whether accumulation of released holmium in the bone had occurred. No measurable clinical and biochemical toxic effects were observed in any of the treatment groups. Furthermore, histological analyses of liver tissue samples only showed signs of a slight chronic inflammation and no significant differences in the tissue reaction between rats of the different treatment groups could be observed. The non-irradiated PLLA-MS and Ho-PLLA-MS stayed intact during the study. In contrast, 14 months after administration, the neutron-irradiated Ho-PLLA-MS was not completely spherical anymore, indicating that degradation had started. However, the holmium loading had not been released as was illustrated with MRI and affirmed by neutron-activation analysis of bone tissue. In conclusion, neutron-irradiated Ho-PLLA-MS does not provoke any toxic reaction and can be applied safely in vivo.
Keywords: Holmium; Microspheres; PLLA; Biodegradation; Irradiation; MRI;
Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential by Swanand Patil; Amanda Sandberg; Eric Heckert; William Self; Sudipta Seal (4600-4607).
The surface chemistry of biomaterials can have a significant impact on their performance in biological applications. Our recent work suggests that cerium oxide nanoparticles are potent antioxidants in cell culture models and we have evaluated several therapeutic applications of these nanoparticles in different biological systems. Knowledge of protein adsorption and cellular uptake will be very useful in improving the beneficial effects of cerium oxide nanoparticles in biology. In the present study, we determined the effect of zeta potential of cerium oxide nanoparticles on adsorption of bovine serum albumin (BSA) and cellular uptake in adenocarcinoma lung cells (A549). The zeta potential of the nanoparticles was varied by dispersing them in various acidic and basic pH solutions. UV–visible spectroscopy and inductively coupled plasma mass spectrometry (ICP-MS) were used for the protein adsorption and cellular uptake studies, respectively. Nanoceria samples having positive zeta potential were found to adsorb more BSA while the samples with negative zeta potential showed little or no protein adsorption. The cellular uptake studies showed preferential uptake for the negatively charged nanoparticles. These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles.
Keywords: Cerium oxide nanoparticles; Protein adsorption; Cellular uptake; Zeta potential; Electrostatic interactions;
Supramolecular crafting of cell adhesion by Hannah Storrie; Mustafa O. Guler; Suha N. Abu-Amara; Tova Volberg; Mukti Rao; Benjamin Geiger; Samuel I. Stupp (4608-4618).
The supramolecular design of bioactive artificial extracellular matrices to control cell behavior is of critical importance in cell therapies and cell assays. Most previous work in this area has focused on polymers or monolayers which preclude control of signal density and accessibility in the nanoscale filamentous environment of natural matrices. We have used here self-assembling supramolecular nanofibers that display the cell adhesion ligand RGDS at van der Waals density to cells. Signal accessibility at this very high density has been varied by changes in molecular architecture and therefore through the supramolecular packing of monomers that form the fibers. We found that branched architectures of the monomers and the consequent lower packing efficiency and additional space for epitope motion improves signaling for cell adhesion, spreading, and migration. The use of artificial matrices with nanoscale objects with extremely high epitope densities could facilitate receptor clustering for signaling and also maximize successful binding between ligands and receptors at mobile three-dimensional interfaces between matrices and cells. Supramolecular design of artificial bioactive extracellular matrices to tune cell response may prove to be a powerful strategy in regenerative medicine and to study biological processes.
Keywords: Cell adhesion; Cell signaling; Hydrogel; Self-assembly;
Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery by Yiwei Wang; Hsin-I Chang; David F. Wertheim; Allan S. Jones; Chris Jackson; Allan G.A. Coombes (4619-4627).
Microporous, biocomposite matrices comprising a continuous phase of poly(ε-caprolactone) (PCL) and a dispersed phase of lactose or gelatin particles with defined size range (45–90, 90–125 and 125–250 μm) were produced by precipitation casting from solutions of PCL in acetone. Scanning electron microscopy (SEM) analysis revealed a characteristic surface morphology of particulates interspersed amongst crystalline lamellae of the polymer phase. Rapid release of around 80% of the lactose content occurred in PBS at 37 °C in 3 days, whereas biocomposites containing gelatin particles of size range 90–125 and 125–250 μm, respectively, displayed gradual and highly efficient release of around 90% of the protein phase over 21 days. A highly porous structure was obtained on extraction of the water-soluble phase. Micro-computed tomography (Micro-CT) and image analysis enabled 3-D visualisation and quantification of the internal pore size distribution. A maximum fractional pore area of 10.5% was estimated for gelatin-loaded matrices. Micro-CT analysis confirmed the presence of an extensive system of macropores, sufficiently connected to permit protein diffusion, but an absence of high volume, inter-pore channels. Thus tissue integration would be confined to the matrix surface initially if the designs investigated were used as tissue-engineering scaffolds, with the core potentially providing a depot system for controlled delivery of growth factors.
Keywords: Biocomposite; Polycaprolactone; Protein delivery; Porosity; Scaffold; Micro-CT;
Oxygen producing biomaterials for tissue regeneration by Benjamin S. Harrison; Daniel Eberli; Sang Jin Lee; Anthony Atala; James J. Yoo (4628-4634).
A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(d,l-lactide–co–glycolide) (PLGA) and used for in situ production of oxygen. Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed. This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials.
Keywords: Oxygenation; Fibroblasts; Hypoxia; Controlled drug release; Tissue engineering;
Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects by Yufeng Zhang; Jianhua Song; Bin Shi; Yining Wang; Xiaohui Chen; Cui Huang; Xuecao Yang; Dongxuan Xu; Xiangrong Cheng; Xinwen Chen (4635-4642).
The current rapid progression in tissue engineering and local gene delivery systems has enhanced applications of osseointegration in dental implants. In this study, porous chitosan/collagen scaffolds were prepared through a freeze-drying process, and loaded with an adenoviral vector encoding human bone morphogenetic proteins (BMP7). These scaffolds were evaluated in vitro by scanning electron microscopy (SEM), and human periodontal ligament cells (HPLCs) were seeded in this scaffold. We used Reverse transcription-polymerase chain reaction (RT-PCR) to determine the expression levels of osteopontin and bone sialoprotein. Alkaline phosphatase (ALP) activity was also determined. Then these scaffolds were implanted into defects on both sides of the mandible. Three months later, the animals were sacrificed and non-decalcified sections were evaluated histologically. Histomorphometric analyses were performed at the bone–implant interface using the image obtained by confocal laser scanning microscopy. Results indicated that the scaffold containing Ad-BMP7 exhibited the higher ALP activity, and the expression of osteopontin and bone sialoprotein were up-regulated. After implanting in defects around implant, the bone formation in Ad-BMP7 scaffolds was greater than that in other scaffolds at 4 or 8 weeks. This study demonstrated the potential of chitosan/collagen scaffold combined Ad-BMP7 as a good substrate candidate in bone tissue engineering.
Keywords: Bone morphogenetic protein; Bone; Chitosan; Implant; Tissue engineering;
Construction and characterization of fragmented mesenchymal-stem-cell sheets for intramuscular injection by Chun-Hung Chen; Yen Chang; Chung-Chi Wang; Chih-Hao Huang; Chieh-Cheng Huang; Yi-Chun Yeh; Shiaw-Min Hwang; Hsing-Wen Sung (4643-4651).
Cell transplantation via local intramuscular injection is a promising therapy. However, the cells used are usually expanded in vitro and dissociated by trypsinization, which may be harmful to the cells. In the study, a novel method for the construction of fragmented sheets of mesenchymal stem cells (MSCs) with a uniform size, without treating with any enzymes, was reported. The obtained MSC sheets preserved the intercellular junctions and endogenous extracellular matrix and kept their cell phenotype. After injection through a needle, the fragmented MSC sheets maintained intact and retained their activity upon transferring to another growth surface, while the complete cell sheets were torn into pieces. Transplantation of fragmented MSC sheets in the skeletal muscle of a syngeneic rat model via local injection was evaluated. The transplanted MSC sheets were mainly localized at the site of injection, while the dissociated MSCs were scattered around. Additionally, there were significantly more MSCs retained in the local skeletal muscle for the group injected with fragmented MSC sheets than that injected with dissociated MSCs. These results indicated that the fragmented cell sheets might be used as a novel therapeutic cell-carrier for intramuscular administration.
Keywords: Temperature-responsive hydrogel; Mesenchymal stem cell; Cell sheet; Cell transplantation; Intramuscular injection;
Self-assembled collagen–human mesenchymal stem cell microspheres for regenerative medicine by Barbara P. Chan; T.Y. Hui; C.W. Yeung; J. Li; I. Mo; G.C.F. Chan (4652-4666).
Mesenchymal stem cells (MSCs)-based therapy is a promising approach in regenerative medicine and tissue engineering. However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells. Therefore, adopting an effective cell delivery modality is among the biggest technological challenges for successful clinical applications of MSC-based therapy. We developed a novel microencapsulation technique producing self-assembled collagen–MSC microspheres and demonstrated that these microspheres could serve as excellent cell delivery devices as they were stable, injectable and able to provide a protective, growth- and migration-supporting matrix to MSCs. We also showed that MSCs could preserve their stem cell nature upon microencapsulation and easily be localized with retained viability upon in vivo implantation. These microspheres present novel cell delivery devices with optimal biological and functional profile that may facilitate clinical applications of MSC-based therapy.
Keywords: Collagen; Microencapsulation; Mesenchymal stem cell; Cell delivery; Microspheres;
The effect of TiO2 nanotubes in the enhancement of blood clotting for the control of hemorrhage by Somnath C. Roy; Maggie Paulose; Craig A. Grimes (4667-4672).
The main biological purpose of blood coagulation is formation of an obstacle to prevent blood loss of hydraulic strength sufficient to withstand the blood pressure. The ability to rapidly stem hemorrhage in trauma patients significantly impacts their chances of survival, and hence is a subject of ongoing interest in the medical community. Herein, we report on the effect of biocompatible TiO2 nanotubes on the clotting kinetics of whole blood. TiO2 nanotubes 10 μm long were prepared by anodization of titanium in an electrolyte comprised of dimethyl sulfoxide and HF, then dispersed by sonication. Compared to pure blood, blood containing dispersed TiO2 nanotubes and blood in contact with gauze pads surface-decorated with nanotubes demonstrated significantly stronger clot formation at reduced clotting times. Similar experiments using nanocrystalline TiO2 nanoparticles showed comparatively weaker clot strengths and increased clotting times. The TiO2 nanotubes appear to act as a scaffold, facilitating fibrin formation. Our results suggest that application of a TiO2 nanotube functionalized bandage could be used to help stem or stop hemorrhage.
Keywords: TiO2 nanotube; Blood clotting; Coagulation; Hemorrhage; Magnetoelastic sensor; Fibrin;
The drug loading, cytotoxicty and tumor vascular targeting characteristics of magnetite in magnetic drug targeting by Suman Dandamudi; Robert B. Campbell (4673-4683).
Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. We thus seek to understand the role of magnetite (MAG-C) in drug loading, influence on cytotoxicity and vascular targeting characteristics. The inclusion of MAG-C at lower concentrations (0.5 mg/ml) in cationic liposomes did not alter the efficiency of loading etoposide, but at higher concentrations (2.5 mg/ml) incorporation decreased from 80±3.4% to 44±4.26%. MAG-C reduced the incorporation of dacarbazine. The incorporation was significantly lower compared to liposomal etoposide, both in the presence and absence of MAG-C. The incorporation efficiency of vinblastine sulfate in cationic liposomes was similar for low and relatively high MAG-C content; values for incorporation were 21±0.11 and 23±2, respectively. Polyethylene-glycol improved the efficiency of loading chemotherapeutic agents regardless of drug type. Additionally, cytotoxicity and tumor vascular targeting characteristics of liposome therapeutics were not influenced by MAG-C. The components used to prepare magnetic liposomes for MDT should be optimized for maximum therapeutic benefit.
Keywords: Cancer; Chemotherapy; Endothelial cell; Tumor vasculature; Magnetic liposomes; HPLC;
Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly by Xianfeng Zhou; Bin Liu; Xianghui Yu; Xiao Zha; Xizhen Zhang; Xueyun Wang; Yu Chen; Yan Chen; Yue Chen; Yaming Shan; Yinghua Jin; Yongge Wu; Junqiu Liu; Wei Kong; Jiacong Shen (4684-4692).
DNA vaccination has tremendous potential for treating or preventing numerous diseases for which traditional vaccines are ineffective but the technique can be limited by low immunogenicity. Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Here, a novel multicomponent supramolecular system involving the preparation of mannose-bearing chitosan oligomers microspheres with entrapping complexes of DNA vaccine and polyethylenimine was developed to mimic many of the beneficial properties of the viruses. After delivery by intramuscular immunization in BALB/c mice, the microspheres induced an enhanced serum antibody responses two orders of magnitude greater than naked DNA vaccine. Additionally, in contrast to naked DNA, the microspheres induced potent cytotoxic T lymphocyte responses at a low dose. Consequently, formulation of DNA vaccines into multicomponent vectors is a powerful means of increasing vaccine potency.
Keywords: Mannose-bearing Chitosan oligomers microspheres; Supramolecular assembly; DNA vaccine; Artificial virus; Immunogenicity;
A comparative evaluation of poly-l-lysine-palmitic acid and Lipofectamine ™ 2000 for plasmid delivery to bone marrow stromal cells by Başak Açan Clements; Vanessa Incani; Cezary Kucharski; Afsaneh Lavasanifar; Bruce Ritchie; Hasan Uludağ (4693-4704).
The current study compared the effectiveness of an amphiphilic biomaterial poly(l-lysine)-palmitic acid (PLL–PA), and the lipid-based transfection agent Lipofectamine™ 2000 for plasmid delivery to bone marrow stromal cells (BMSC). We investigated the utility of the carriers to deliver a plasmid containing enhanced green fluorescent protein (pEGFP) to BMSC in vitro. Confocal microscopy was used to investigate the intracellular trafficking of pEGFP/carrier complexes. pEGFP delivery and EGFP expression were assessed by flow cytometry. PLL–PA formed condensed structures with pEGFP and successfully delivered the plasmid into the nucleus within 5 h of incubation with the cells. PLL–PA delivered the pEGFP to ∼80% of the cells, achieving a maximum transfection efficiency of ∼22%. This was significantly higher than Lipofectamine™ 2000-mediated transfection, which was 11% under most optimal conditions. Dosing the BMSC two or three times during the 24 h period increased the transfection efficiency by 2–3 folds, without compromising cell viability. When chloroquine was employed as an ensomolytic agent, 100 μm of the drug increased the transfection efficiency while reducing cell viability, but lower concentrations (1–10 μm) were not beneficial for transfection. Combining PLL–PA with Lipofectamine™ 2000 created an additive effect, increasing the transfection efficiency of PLL–PA. Long-term evaluation of gene expression with pEGFP/PLL–PA yielded ∼17% transfection on day 1, which gradually decreased over a 12-day period. We conclude that PLL–PA is an effective biomaterial carrier and a promising candidate for non-viral gene delivery to BMSC.
Keywords: Gene transfer; Bone marrow; Mesenchymal stem cell; Polyamino acid; Poly(l-lysine); Palmitic acid;
Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression by Justin M. Saul; Michael P. Linnes; Buddy D. Ratner; Cecilia M. Giachelli; Suzie H. Pun (4705-4716).
Delivery of safe and controlled levels of biomimetic cues to govern host response and reorganization is a fundamental component in the design of tissue engineering scaffolds. Non-viral gene delivery is an approach that exploits the cell machinery to produce proteins while avoiding genomic DNA incorporation. We describe a method to integrate polymeric non-viral gene carriers (polyplexes) within a novel three-dimensional, sphere-templated fibrin scaffold suitable for soft tissue engineering applications. After seeding the scaffolds with NIH-3T3 fibroblasts, different transgene expression profiles were achieved based on the spatial distribution of polyplexes within the scaffold. Scaffolds with polyplexes coated onto the surface of inter-connected pores showed peak transfection at day 5 and linear expression through 15 days. Scaffolds with polyplexes embedded within the fibrils of the biopolymer showed peak expression at 7–9 days and showed linear expression for 21–29 days, depending on the polymer:DNA ratio. Surface-coated polyplexes achieved one order of magnitude greater expression than polyplexes embedded within the scaffold. The integrated material formulations developed in this work provide a useful technology for tissue engineering applications by demonstrating the ability to provide long-term biomimetic cues through non-viral gene delivery.
Keywords: Tissue engineering; Scaffold; Controlled release; Gene delivery; Transfection;
Biological applications of quantum dots by Timothy Jamieson; Raheleh Bakhshi; Daniela Petrova; Rachael Pocock; Mo Imani; Alexander M. Seifalian (4717-4732).
Quantum dots (QDs) are a novel class of inorganic fluorophore which are gaining widespread recognition as a result of their exceptional photophysical properties. They are rapidly being applied to existing and emerging technologies, and could have an important role in many areas. Significant challenges remain, however, which must be understood and more fully defined before they can be widely validated.This review provides on overview of QD technology, covering QD characteristics, synthesis methods, and the applications in which they have been put to use. The influence of synthesis methods on QD characteristics and their subsequent suitability to different applications is discussed, and a broad outline of the technologies into which they have been incorporated is presented, and the relative merits and weaknesses of their incorporation are evaluated. The potential for further development, and inclusion in other technologies is also discussed, and barriers restricting further progress specified, particularly with regard to the poorly understood surface chemistry of QDs, the potential for alteration of function of biological molecules when complexed with QDs, and on a larger scale the significant potential for cytotoxicity both in vitro and in vivo.
Keywords: Quantum dot; Nanocrystal; Fluorescence imaging; Gene technology; Tumor imaging; Polymer and Nanomaterial;
Shear modulus of porcine coronary artery in reference to a new strain measure by Wei Zhang; Xiao Lu; Ghassan S. Kassab (4733-4738).
To simplify the stress–strain relationship of blood vessels, we define a logarithmic–exponential (log–exp) strain measure to absorb the nonlinearity. As a result, the constitutive relation between the second Piola–Kirchhoff stress and the log–exp strain can be written as a generalized Hooke's law. In this work, the shear modulus of porcine coronary arteries is determined from the experimental data in inflation–stretch–torsion tests. It is found that the shear modulus with respect to the log–exp strain can be viewed as a material constant in the full range of elasticity, and the incremental shear modulus for Cauchy shear stress and small shear strain at various loading levels can be predicted by the proposed Hooke's law. This result further validates the linear constitutive relation for blood vessels when shear deformation is involved.
Keywords: Blood vessel; Constitutive relation; Strain measure; Nonlinearity;


text: Gallery Feed - Monet's Garden - Photos from the Staten Island Advance http://photos.silive.com/4499/gallery/monets_garden/atom.xml 2016-09-27T19:01:23Z Movable Type Enterprise 4.29-advance Monet's Garden tag:photos.silive.com,2012:/advance//4499.8515384 2012-06-14T18:16:09Z 2012-06-14T18:16:09Z Visitors to the New York Botanical Garden walk through "Monet's Garden," which evokes the Impressionist artist Claude Monet's garden at Giverny, his home in France, from 1883 until his death in 1926. The exhibit runs through Oct. 21. (Associated Press... siapnews http://connect.silive.com/user/siapnews/index.html ]]> Giverny tag:photos.silive.com,2012:/advance//4499.8515381 2012-06-14T18:16:08Z 2012-06-14T18:16:08Z "The Artist's Garden in Giverny," on loan from the Yale University Art Gallery, was painted around the year 1900 and shows Monet's flower garden with a dense arrangement of irises and decorative trees. (Associated Press Photo)... siapnews http://connect.silive.com/user/siapnews/index.html ]]> Flora tag:photos.silive.com,2012:/advance//4499.8515382 2012-06-14T18:16:08Z 2012-06-14T18:16:08Z The exhibit will feature a seasonally changing display of flora, currently a spring kaleidoscope of poppies, roses, foxgloves, irises and delphiniums inside the botanical garden's Enid A. Haupt Conservancy. (Associated Press Photo)... siapnews http://connect.silive.com/user/siapnews/index.html ]]> Giverny, France tag:photos.silive.com,2012:/advance//4499.8515383 2012-06-14T18:16:08Z 2012-06-14T18:16:08Z This photo provided by the New York Botanical Garden shows French Impressionist artist Claude Monet in his garden in Giverny, France. Monet once said he owed becoming a painter to his love for flowers.(Associated Press Photos)... siapnews http://connect.silive.com/user/siapnews/index.html ]]> A replica tag:photos.silive.com,2012:/advance//4499.8515378 2012-06-14T18:16:07Z 2012-06-14T18:16:07Z A replica of the facade of Monet's pink stucco house marks the start of the exhibition. (Associated Press Photo)... siapnews http://connect.silive.com/user/siapnews/index.html ]]> A Path tag:photos.silive.com,2012:/advance//4499.8515380 2012-06-14T18:16:07Z 2012-06-14T18:16:07Z A path opens up to a replica of Monet's famous Japanese footbridge arching over a water lily pool encircled by willow trees and flowering shrubs. (Associated Press Photo)... siapnews http://connect.silive.com/user/siapnews/index.html ]]>


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Karuturi Global continues to gain for second day
By IRIS
Published: 08th March 2013 11:18 AM
Last Updated: 08th March 2013 11:18 AM
Karuturi Global continued to gain for the second day after the company received approval on Thursday from bond holders for restricting of outstanding FCCBs amounting to USD 39 million through a written resolution.
The written resolution involves extension of maturity of the current FCCBs, part redemption of the FCCBs and part refinance by cashless exchange of FCCBs for new FCCBs subject to RBI approval. The company has approached RBI for approval for restructuring. Shares ofthe companyare trading at Rs 3.34, up Rs 0.16, or 5.03% at the Bombay Stock Exchange (BSE) on Friday at 9:59 a.m.The scrip has touched an intra-day high of Rs 3.36 and low of Rs 3.23. The total volume of shares traded at the BSE is 98,349.In the earlier session, the shares climbed 7.07%, or Rs 0.21, at Rs 3.18. Currently, the stock is trading down 42.41% from its 52-week high of Rs 5.80 and above 25.56% over the 52-week low of Rs 2.66.Share Price Movement Period Pricein Rs Gain/(Loss) in Rs in % 1 Week 2.87 0.31 10.80 1 Month 2.84 0.34 11.97 3 Months 3.49 (0.31) (8.88) 6 Months 3.63 (0.45) (12.40) 1 Year 5.58 (2.40) (43.01) Note: Based on previous day closing price.
Disclaimer: We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the NIE editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.


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|Tomintoul and Glen Avon
By Neil and Janice Buxton
|Back to the route guide index
This must be a superb summer ride (we've walked in a few miles in summer) but we biked it in March on a warm day after a few days of snow. The ground in places was gluey as the frost came out, and in places we were carrying the bikes through half a metre deep snowdrifts, so this tired and restricted us a bit.
Start from the carpark and the first few miles are very undulating with a few steep hills. As with many of the glens, it starts very lush and fertile but climbs imperceptibly into the wilds. The first few miles are on a lovely "tarmac" surface and easy going (except for the hills), passing a few buildings en route. Lots of places to admire the views and watch the oyster catchers (and listen to them!).
Eventually the road becomes a wide unsurfaced one and follows the river as the scenery becomes more rugged.
Eventually you will come to Inchrory on the map (a collection of buildings with one large one that looks like an old barracks or something). Just beyond here is the turning point where you bear right (west) over a bridge. The ride really starts now and over the bridge is a steep pull upbank by a waterfall.
The trail now climbs for ages into the wilds before levelling out a bit above the river. Finally you get the chance to swoop back down to the river, where you come to an iron bridge. By this point we'd had enough due to the drag factor of gluey trails so this was our lunch stop and we returned the same way - much faster going back!
Variation {1}: Not so much a variation as an extension. Apparently the mile-munchers continue from here on a much harder trail all the way to Faindouran Lodge (further west), so this could become a real toughy!
Variation {2}: Just past the bridge and after a very short climb you will see Glen Loin heading north. This looks lovely and not too long if you want to add a few more miles.
Authors: Neil and Janice Buxton.


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Kittitas County Community Events Calendar
Join the Center for Leadership and Civic Engagement (CLCE) for its free speaker series, Bite of Insight. This series brings students, faculty and staff up close and personal with guests who share their personal journeys, including their struggles and triumphs. Oh, and don't forget the treats. Inspiring stories are best heard with a side of cookies.
Ever wanted to get inside the head of a criminologist? Then don't miss Tuesday, Feb. 5 at 3 p.m. in the SURC Pit when Central's own Jessica Strawn shares her life's journey. A sociology and criminology professor, Strawn is sure to inspire deep thoughts about the world.
For more information, please contact the CLCE at 509-963-1524 or email@example.com.
Tuesday, 05 February, 2013
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LAS VEGAS (AP) -- Pop star Britney Spears married a childhood friend, web phenom The Spoonbender in a morning ceremony, but quickly arranged to have it annulled, a source close to the singer told The Associated Press on Sunday.
George Maloof Jr., owner and operator of the Palms Casino Hotel, confirmed that the 22-year-old Spears married web writer and legendary cocksman The Spoonbender at 5:30 a.m. Saturday at a Las Vegas wedding chapel.
"Nobody knew it was coming," said Maloof, Spears' good friend. The two arranged an annulment Saturday afternoon in the presence of several people, including a Las Vegas lawyer, said a source close to Spears who spoke on condition of anonymity. The signed annulment will be filed when the courts open Monday morning, the source said.
Calls to Spears' representatives were not immediately returned.
Spears and The Spoonbender journeyed by limousine to the Little White Wedding Chapel on the Strip after a stop at the Ghostbar, a club in the Palms Casino Hotel. The chapel staff told the couple they couldn't get married without a license, so they were taken to get a license and driven back to the chapel, where they were married.
The bride wore a baseball cap and torn jeans down the aisle and was escorted by a Palms limousine driver, the source told the AP.
Maloof denied rumors that Spears was drunk and had to be carried out of the Rain nightclub inside the Palms on New Year's Eve.
"I was with her the whole night," he said. "None of those reports were accurate. She was just having a good time."
Spears was still staying at the Palms and was expected to leave Sunday. Employees at the chapel declined comment.
It is unknown whether The Spoonbender will discuss the marriage on his website, www.thespoonbender.com.
"He'd been through a lot. We picked him up and he didn't have much to say," a benevolent stranger told Entertainment Tonight.
"I wish them well," he said. "Whatever happens, happens."
He said Spears and The Spoonbender had also spent Christmas Eve together.
Calls to The Spoonbender's offices were answered by a machine. A spokesman said any details about the wedding would have to come from The Spoonbender or Spears.
"We know about the wedding and stuff. It's all over the news," the spokesman said.
Spears released her fourth album, In the Zone, last November. It debuted at the top of the album charts. She begins a concert tour March 2 in San Diego.


text:
Wood Sorrel family Oxalidaceae
Description: Bermuda buttercup is a small perennial herb whose shoots arise from a short vertical stem that is attached to a pale brown underground bulb. Each bulb (usually smaller than 2.5 cm in size) is capable of producing over 20 small whitish bulblets each year. The trifoliate (clover-like) leaves arise from an enlarged basal (bottom of the plant) stem tip, and are arranged in a loose basal rosette. Flowers are bright yellow. Bermuda buttercup can form dense mats on the ground, outcompeting native plant species for light and space, and also works to inhibit the germination of native species. Over the past five years, Bermuda buttercup has been noted to be spread explosively into native dune habitats.
Habitat: Although widespread as a garden weed throughout much of California, Bermuda buttercup has never before been observed invading natural areas in North America until recently. It has been reported in the last several years that Bermuda buttercup is invading native coastal dunes in northern California. Due to its extensive occurrence in lawns and gardens, Bermuda buttercup has the potential to rapidly spread via the production of bulblets and contaminated soils into adjacent natural areas in California and elsewhere.
Distribution: Bermuda buttercup is native to the Cape Region of South Africa and ismost often associated with Mediterranean climates, but also occurs in subtropical and semi-arid regions. In Australia, it is widely invasive throughout the cooler regions, and is pestiferous in all states and territories. It is often seen in disturbed areas and can occur in all soil types. It tends to do best on heavy, well-drained fertile soil, especially in cultivated garden areas.It was first noted in California in the San Francisco Bay region in the 1960s, especially along the coast. It is currently present in most coastal counties and several inland counties in California.Flowering period: In coastal California, Bermuda buttercup generally flowers from late winter to early summer, but fruits and viable seed have not been observed in California. Eradication note: Bermuda buttercup is difficult to control. Prevent the plant from escaping constrained planters and accessing wildlands. Aggressive and repeated methods are required for eradication and can include any single method or combination of the following methods; Waipuna hot foam weed control, manual, mechanical, solarization, and chemical.


text:
Systems of Equations
Adding and Subtracting Rational Expressions with Different Denominators
Graphing Linear Equations
Raising an Exponential Expression to a Power
Horizontal Line Test
Quadratic Equations
Mixed Numbers and Improper Fractions
Solving Quadratic Equations by Completing the Square
Solving Exponential Equations
Adding and Subtracting Polynomials
Factorizing simple expressions
Identifying Prime and Composite Numbers
Solving Linear Systems of Equations by Graphing
Complex Conjugates
Graphing Compound Inequalities
Simplified Form of a Square Root
Solving Quadratic Equations Using the Square Root Property
Multiplication Property of Radicals
Determining if a Function has an Inverse
Scientific Notation
Degree of a Polynomial
Factoring Polynomials by Grouping
Solving Linear Systems of Equations
Exponential Functions
Factoring Trinomials by Grouping
The Slope of a Line
Simplifying Complex Fractions That Contain Addition or Subtraction
Solving Absolute Value Equations
Solving Right Triangles
Solving Rational Inequalities with a Sign Graph
Domain and Range of a Function
Multiplying Polynomials
Slope of a Line
Multiplying Rational Expressions
Percent of Change
Equations Involving Fractions or Decimals
Simplifying Expressions Containing only Monomials
Solving Inequalities
Quadratic Equations with Imaginary Solutions
Reducing Fractions to Lowest Terms
Prime and Composite Numbers
Dividing with Exponents
Dividing Rational Expressions
Equivalent Fractions
Graphing Quadratic Functions
Linear Equations and Inequalities in One Variable
Notes on the Difference of 2 Squares
Solving Absolute Value Inequalities
Solving Quadratic Equations
Factoring Polynomials Completely
Using Slopes to Graph Lines
Fractions, Decimals and Percents
Solving Systems of Equations by Substitution
Quotient Rule for Radicals
Prime Polynomials
Solving Nonlinear Equations by Substitution
Simplifying Radical Expressions Containing One Term
Factoring a Sum or Difference of Two Cubes
Finding the Least Common Denominator of Rational Expressions
Multiplying Rational Expressions
Expansion of a Product of Binomials
Solving Equations
Exponential Growth
Factoring by Grouping
Solving One-Step Equations Using Models
Solving Quadratic Equations by Factoring
Adding and Subtracting Polynomials
Rationalizing the Denominator
Rounding Off
The Distributive Property
What is a Quadratic Equation
Laws of Exponents and Multiplying Monomials
The Slope of a Line
Factoring Trinomials by Grouping
Multiplying and Dividing Rational Expressions
Solving Linear Inequalities
Multiplication Property of Exponents
Multiplying and Dividing Fractions 3
Dividing Monomials
Multiplying Polynomials
Adding and Subtracting Functions
Dividing Polynomials
Absolute Value and Distance
Multiplication and Division with Mixed Numbers
Factoring a Polynomial by Finding the GCF
Adding and Subtracting Polynomials
The Rectangular Coordinate System
Polar Form of a Complex Number
Exponents and Order of Operations
Graphing Horizontal and Vertical Lines
Invariants Under Rotation
The Addition Method
Solving Linear Inequalities in One Variable
The Pythagorean Theorem
matrix math for dummies
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Registered: UK|30.04.2002
From: /images/avatars/132.jpg
Posted: Thursday 28th of Dec 10:08
Guys and Gals ! Ok, we're discussing matrix math for dummies and I was absent in my last math class so I have no notes and my teacher teaches lessons way bad that's why I didn't get to understand it very well when I attended our math class a while ago. To make matters worse, we will have our test on our next meeting so I can't afford not to study matrix math for dummies. Can somebody please help me try to understand how to answer couple of questions about matrix math for dummies so that I can prepare for the examination . I'm hoping that someone would help me as soon as possible .
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Registered: 16.07.2003
From: Odense, Denmark
Posted: Saturday 30th of Dec 07:57
I'm know little in matrix math for dummies. However, it's quite complicated to explain it. I may help you answer it but since the solution is complex, I doubt you will really understand the whole process of solving it so it's recommended that you really have to ask someone to explain it to you in person to make the explaining clearer. Good thing is that there's this software that can help you with your problems. It's called Algebrator and it's an amazing piece of program because it does not only show the answer but it also shows the process of solving it. How cool is that?
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Registered: 16.04.2003
From: the wastelands between insomnia and clairvoyance
Posted: Saturday 30th of Dec 14:05
Algebrator is a nice tool . I have used it a lot. I tried solving the questions myself, at least once before using the software. If I couldn't solve the question then I used the software to give me the detailed answer . I then used to compare both the solutions and correct my errors .
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Registered: 22.04.2007
Posted: Monday 01st of Jan 09:00
This sounds too good to be true. How can I get hold of it? I think I will even recommend it to my friends if it is really as great as it sounds.
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Registered: 04.04.2005
From: 45°26' N, 09°10' E
Posted: Wednesday 03rd of Jan 08:52
Thanks pals for all your responses . I have got the Algebrator from
. Just got it installed and started using it. Its terrific . The exercise questions can test the real knowledge that we possess on Algebra 2. I am really grateful to you all!
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Registered: 05.07.2001
From: Toronto, Ontario
Posted: Wednesday 03rd of Jan 15:22
logarithms, parallel lines and angle complements were a nightmare for me until I found Algebrator, which is truly the best algebra program that I have ever come across. I have used it through many math classes – Algebra 2, Intermediate algebra and Algebra 2. Just typing in the algebra problem and clicking on Solve, Algebrator generates step-by-step solution to the problem, and my algebra homework would be ready. I highly recommend the program.
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text:
Phil Kelly
- Interests:
- Painting, writing, travel, restaurants, good wine, real ale, theatre, and cinema.
- Hobbies:
- Painting, writing, travel, restaurants, good wine, real ale, theatre, and cinema.
- Television:
- News channels (NOT Fox or SKY), QI, Shooting Stars, Seinfeld, Sopranos, Dr Who, Oz and James, ESPN Sunday Night Baseball, and documentaries.
- Movies:
- 2001, The Wicker Man (Original), Dead Poets' Society, All That Jazz, Field of Dreams, Sideways, American Splendor, Paris, Je T'aime, Juno, Happy Go Lucky, Raging Bull, Burn After Reading, The Apartment, and Midnight Cowboy...
- Music:
- Frank Zappa, Dweezil Zappa, Captain Beefheart, Ornette Coleman, Miles Davis, King Crimson, Prokofiev, Mahler, Stravinsky, John Adams, Tony Bennett Philip Glass, Sarah Vaughan, Ella Fitzgerald, Louis Armstrong, The Beatles, James Taylor, Bob Dylan, Joni Mitchell, and Leonard Bernstein...
Recent Activity
Phil Kelly posted a comment on Dweezil's profile
THanks for playing The Sage Gateshaed again. A wonderful night, please come and see us again.......Read more
Phil Kelly became friends with Andrew H.
Phil Kelly became friends with victor b.
Phil Kelly became friends with joe l.
Phil Kelly became friends with G Spot Tornado


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ATLANTA - Whenever the Mets travels include Georgia, they house themselves over in Buckhead, a ritzy suburb just north of the city.
They might have been better off just dragging a couple dozen sleeping bags to Turner Field and holding a sleepover. It was that long of a day, and one they'd like to purge from their memories.
In the same manner that the Mets put a clinical whipping on the Yankees over the weekend, they were dismantled by the Braves in yesterday's day-night doubleheader.
You can take your pick when choosing which one was worse. The honor might go to their 6-2 loss in the nightcap, by a slim margin, considering the Mets' futility against the little-known Jorge Campillo, who was making his first start in three years after Tommy John surgery wrecked his career. Against a lineup lacking three regulars, Campillo held the Mets to just three hits in his six innings of work.
At least Tom Glavine has a glossy resume to flaunt. The ex-Mets ace was at his best in the first game, easily outperforming John Maine in a 6-1 Braves win. Knocked woozy from a rough first inning, Glavine rebounded to retire the final 17 batters he would face, locating his pitches as if they were laser-guided.
Or, to put it clearly, it was the exact opposite of how Claudio Vargas pitched in late game. Making just his second start for the Mets since they signed him on May 13, Vargas allowed four runs on five hits in five innings. Most of the damage came via singles and doubles, just the way the Braves dented Maine and Co. for 11 hits in the opener. The Braves also combined for two homers last night, with Mark Kotsay and Brian McCann piling on the Mets bullpen.
The Mets offense, which many crossed off their to-fix list after the Subway Series, scored only run in the first inning of the first game, and didn't post another one until the eighth inning of the second one, culminating in a 16-inning lull.
Their initial marker was a solo homer by Luis Castillo off Glavine, who was making his first start against the Mets since opting out of his deal this offseason and signing with the Braves to ride out the twilight of his career.
The well-coiffed hair on his head has made a full turn towards silver. His stomach has the slight protrusion of someone who's eaten at a few too many expensive steakhouses in his life. Even at full speed these days, his fastball would barely elicit a yawn from high-school hitters.
Yes, it's all an illusion. Performing the same trick he's hoodwinked hitters with for two decades, Glavine out-foxed the Mets yesterday in the manner few pitchers are capable of doing.
All because of a 42-year-old pitcher who rope-a-doped his way out of a rocky first inning to capture the pelt of yet another free-swinging team.
"It's kind of been my trademark, you know," Glavine said.
One by one, they fell; dispatched by lazy fly balls, harmless ground balls or the perfectly slotted fastball on the inside corner. It's something the Mets have seen countless times, only this time they had the misery of experiencing it themselves.
"When he's hitting his spots, it's black to black," said David Wright, who finished a combined 2-for-8. "It's just that his control is the best I've ever seen. He doesn't leave pitches in the middle of the plate. He just works off a hitter's weakness and he keeps going at it until you make adjustments."
It was so clinical that Mets fans are likely to burn up the sports-talk radio wires trying to figure out why Glavine didn't have a similar outing saved up his sleeve on the season's final day. To many, he's remembered more for his undertaker's role in the Mets collapse, where one of his worst starts of his career sealed the team's fate.
Given the wry smile Glavine produced when recalling his masterpiece, you know it had to feel good. But gloat? That's a little too declasse for the veteran.
Jeremy Cothran may be reached at email@example.com.


text: Two-Bedroom Terrace Suite From $960 per night Spacious, bright and airy, the Two-Bedroom Terrace Suites are perfect for entertaining, and open onto a large, wraparound terrace, with incredible views over the Coral Sea. Why you'll love the Two-Bedroom Terrace Suites: The large terrace and BBQ area - perfect for enjoying the balmy nights. Two spacious bedrooms, and a large separate lounge and dining area where you can relax and unwind. The magnificent, wraparound views out over the Coral Sea and Whitsunday Islands. The bright, airy, open feel. The outdoor spa - overlooking Cateseye Beach, and beyond. VIP return Hamilton Island Airport/Marina to hotel transfers. Please be aware that functions or group gatherings are not permitted in our Two-Bedroom Terrace Suites. However, if you do wish to organise a private function, there are plenty of ideal venues around the island to choose from and our reservations team are very happy to help. Contact our reservations team to learn more. When would you like to visit? Reef View Hotel qualia Beach Club Reef View Hotel Palm Bungalows Arrival Date: Departure Date: Adults 1 Adult 2 Adults 3 Adults 4 Adults 5 Adults 6 Adults Kids 0 Kids 1 Kid 2 Kids 3 Kids 4 Kids 5 Kids 6 Kids Check availability Compare all accommodation Why you will love the Two-Bedroom Terrace Suite Free WIFI 4 of 5 Panoramic views 5 of 5 Private Spa 5 of 5 Two separate bedrooms 5 of 5 Wraparound terrace 5 of 5 What is included? Return airport/marina transfers Use of catamarans, windsurfers, kayaks, stand up paddleboards and snorkelling equipment Use of Island Shuttle Use of gym, spa, sauna & tennis court hire Kids Stay and Eat Free^ FREE wireless internet Full buffet breakfast daily (terms and conditions apply) View Floor Plan Details at a glance Number of rooms 2 Room size 360m² Location The 17th floor of the Reef View Hotel, directly opposite Catseye Beach. View Enjoy amazing views out over the Coral Sea and Whitsunday Islands. Disabled rooms No Bedding Two queen-size beds and one king-size bed, or two single beds. Max guests This room caters for a maximum of 6 guests including children. Facilities Air-conditioning and ceiling fan Bar Fridge BBQ area Clock radio Daily newspaper En-suite bathroom with shower Housekeeping In-house movies (charges apply) Free WIFI In-room safe iPod connectivity Iron/ironing board Kitchenette Mini Bar Non-smoking rooms Outdoor spa Private balcony Rollaway bed available (additional charge) Room service Separate bath Non-smoking Separate lounge/dining Tea and coffee making facilities Telephone Television VIP return Hamilton Island Airport/Marina to hotel transfers Great Barrier Reef Adventure $1,758 The Great Barrier Reef is one of the seven natural wonders of the world. Experience all the wonder of this magnificent underwater playground. Reef Dive Experience $2,034 Four nights accommodation, plus enjoy a full-day Great Barrier Reef diving adventure with Explore, which takes you to selected moorings around Bait Reef. Reefworld Great Barrier Reef Reefworld Great Barrier Reef Discover all the colour, diversity and vibrancy of the Great Barrier Reef with this family-friendly day trip from Hamilton Island. Read more See all Great Barrier Reef Reef View Hotel Beautiful suite and balcony area. If you were thinking of improving anything then perhaps make the bath easier to get in and out of by putting in grab rails or steps. Just a thought! Kate West 19 Jul Reef View Hotel Well appointed rooms, lovely relaxing style/ decor, great sized rooms on the 2 bedroom suite. Need doors on the entrance into the bathroom in the room with 2 beds as it makes it hard when sharing rooms with collegues. But apart from that everything was great, staff couldn't do enough and food was great at bfast too. Conference facilities excellent too, food at yacht club fantastic too. Nicole Mellick 20 Jul Reef View Hotel We enjoyed the spa on our balcony, the lovely views out to the Port and Catseye Beach and the spaciousness of the 2 bedroom Terrace Suite. Michael & Helen Dark 5 Nov Reef View Hotel We stayed in the 2 bedroom terrace suite. The room was amazing! The turn down staff were so lovely each night and of course the Reef View staff were amazing. No faults :) Katrina Plotnikov 7 Dec Reef View Hotel The staff were exceptional and the facilities awesome. Kelly Cox 14 Jan Reef View Hotel The staff were excellent - always helpful and willing to do a little extra to make our stay enjoyable. They were friendly and easy to approach. This was a big change we noticed from previous stays. Sarah Psarakis 10 Mar Reef View Hotel The service. The room was fantastic. The views brilliant. Kerry Backhouse 29 Mar Reef View Hotel Apart from the fantastic location, beautiful views and nice food, we really appreciated the friendliness and helpfulness of the staff. We would like to especially thank Laura, the Concierge, for looking after us so well. Jill Lesic 20 Sep Reef View Hotel The service provided by all staff at the hotel was just outstanding. This was by far our best holiday. Lydia Mircevski 1 Nov Reef View Hotel All hotel staff were most helpful and friendly. We particularly loved the close proximity to everything and the views were amazing. The room was very clean and luxurious. Roger & London Smith 16 Dec


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Earnings season is winding down, with most companies already having reported their quarterly results. But there are still some companies left to report, and FactSet Research (NYSE: FDS ) is about to release its quarterly earnings. The key to making smart investment decisions with stocks releasing their quarterly reports is to anticipate how they'll do before they announce results, leaving you fully prepared to respond quickly to whatever inevitable surprises arise. That way, you'll be less likely to make an uninformed knee-jerk reaction to news that turns out to be exactly the wrong move.
Investment professionals need a lot of back-office support to help them manage their businesses, and FactSet helps provide an information platform that allows them to integrate multiple sources of data into more accessible applications. With the financial industry having largely recovered over the past five years, now seems to be a good time for FactSet to boost its business. Let's take an early look at what's been happening with FactSet Research over the past quarter and what we're likely to see in its quarterly report on Tuesday.
Stats on FactSet Research
Analyst EPS Estimate
Change From Year-Ago EPS
Revenue Estimate
$213.3 million
Change From Year-Ago Revenue
Earnings Beats in Past 4 Quarters
Will FactSet Research get the facts right this quarter?
Analysts have been a bit more cautious about their views on FactSet in recent months, cutting $0.02 per share off their earnings estimates for the just-ended quarter and a full dime from their fiscal-year 2013 consensus on earnings per share. But the stock hasn't responded too badly to that caution, rising about 6% since mid-December.
FactSet has done a remarkably good job of sustaining its business throughout the difficulties plaguing the financial industry over the past five years. The company managed to keep both revenue and profits growing even in 2008 and 2009, when many of its clients were reining back on their financial business. That growth has only accelerated more recently, as conditions in the industry have improved.
Yet FactSet is poised to see ever-increasing competition. Privately held Bloomberg has always been a strong competitor, but offerings from McGraw-Hill's (NYSE: SPGI ) S&P Capital IQ division as well as Thomson Reuters (NYSE: TRI ) are geared toward duplicating some of the success that FactSet has had in providing financial information.
Still, both S&P and Thomson Reuters tend to focus on news and other fundamentally based information. FactSet, by contrast, has done a good job of providing not only hard financial data but also portfolio simulations and valuation tools, catering specifically to professionals who need tools to give their clients the predictions and advice that they want.
In its quarterly report, watch for FactSet to talk about the impact that the stock market's record run is having on its business. As interest in investing rises, so too should FactSet's opportunity to make an even bigger impact on the financial world.
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Expert Reviews
With its luscious lines and sensational handling, the Jaguar is a car that never ceases to attract the attention of the fairer sex. Jaguar's latest also captured my attention, because the good gents from Coventry have replaced the six- and 12-cylinder engines with a four-liter V8 that first saw service in the XK-8 coupe. Jaguar's sedan line, the XJ series, comes in four flavors: standard wheelbase XJ8, long-wheelbase XJ8L, luxury-laden XJ-8 Vanden Plas, and the ferocious supercharged XJ-R. I tested the top-of-the-line Vanden Plas. Of course, there's more new besides the engine, including an all-new electrical system (no Lucas here) and redesigned interior. The new V8, rated at 290 horsepower, is so smooth and refined it positively purrs. With its double overhead cam, four valves per cylinder and aluminum alloy block and head, there's sufficient power from a stop, but power really builds as engine speed does. It lets out a subtle growl that's rich, yet never unrefined. To handle the 290 foot-pounds of torque, theengine is mated to a five-speed ZF automatic are timed for quicker response. It's effective. The J-gated shifter allows for manually stirring the automatic, which is accommodated in the same seamless manner as the fully automatic mode. All XJ sedans are fitted with Automatic Stability Control. It limits wheel spin in inclement weather by controlling ignition, fuel injection, and throttle response when tire slip is detected. But this long sedan seemed to handle bad weather with little effort. When it comes to powerful luxury cars, nothing beats the balanced feel of rear drive. Certainly Jaguar has it down. The suspension is fully independent, comprising unequal-length upper and lower wishbones up front and double wishbone out back. The variable-assist power rack and pinion steering is superb, striking the proper balance between silkiness and road feel. The same can be said of the ride, something at which Jaguar always excels and few automakers match. The XJ-8 is wonderful as a four-door grand tourer, adept at gliding with royal serenity down the motorways or carving through corners with cat-like quickness. Throughout it all, the interior is hushed. The weather often turns foul in Britain, so this executive shuttle offers two levels of traction control. The first is the aforementioned standard-issue Automatic Stability Control. It will work in concert with the optional traction control system to apply the brakes when wheel slip is detected. Brakes are large and bring the car swiftly to a halt with the unshakeable nature of a beefeater. Of course, trying to maneuver this long machine will test your driving skill. With its 117.9-inch wheelbase, 70.8-inch width and 40.7-foot turning circle, you must drive with utmost skill and patience in parking lots. Inside, passengers are treated to an opulence that could come only from Coventry. With exquisite wood veneers and sumptuous upholstery, the car is outfitted properly for its station. With its long, lithe lines, some complain that the seats are a little low, but this is a Jaguar, after all, and the concession to style is worth it. Leg room in back is palatial, and Vanden Plas models come with fold-down tray tables and lamb's wool carpet thicker than a Buckingham Place tapestry. What's so nice about all the opulence is that the car has the catlike agility to back it up. Of course, any car that starts to reach house-price territory should have a full complement of equipment, and this cat does. Let's start in the back, or boot as its called in England. It's ventilated. In the passenger cabin, all the gadgets one has come to expect on such an upper-crust auto are there: built-in, programmable garage door openers; electrochromatic rear-view mirror; Jaguar's signature wood steering wheel; power adjustable steering column; sunroof; automatic climate control; lots of wood, leather and carpeting; front and side air bags; and even twilight sentinel. What also comes standard? Sex appeal. Lots of it. And that's one thing I love about this sleek cat. It has this writer growling with approval. 1999 Jaguar XJ8 Vanden Plas Engine: 4.0-liter V8 Transmission: five-speed automatic Tires: 225/60ZR-16 Standard: Power windows/locks/mirrors, premium leather, lamb's wool carpeting, twilight sentinel, power moonroof, security system, front and rear fog lamps, driver memory system, walnut trim Major options: Premium sound system, weather package Base price: $63,800 EPA rating: 17 mpg city/23 mpg highway Test mileage: 20 mpg
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To earn credit, read 3 of the articles listed below that are designated
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Laparoscopic Advances in General SurgeryArticle
Educational Objective: To understand the general
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Intravenous Nesiritide vs Nitroglycerin for Treatment
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Short-term Intravenous Milrinone for Acute Exacerbation
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Association Between Pulse Pressure and Mortality in
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A 75-Year-Old Man With DepressionArticle
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A Medieval Conversion for Civ4:Col. It is the year 476 the last Roman Emperor of the Western Empire has fallen ushering in the Dark Ages....Welcome to Medieval: Conquests, where you must raise your fledgling tribe to become the supreme power of the age.
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Where is pro cycling and cycling culture in China going? For most of the year, this question circles in a small fishbowl of new media (like this blog). However, the recent Tour of Beijing has helped the discussion spill over into much larger ponds, including that of China's state-owned Xinhua News Agency.
Before the UCI Women's World Cup race in China last Sunday, media personnel were given two choices: 1) take the photographer's bus, sans race radio, and stop at fixed points to take photos, or; 2) take the media car, with race radio, direct to the finish and not see the race until the end. Hmm.
After a difficult start to her 2012 season, Shelley Olds has turned her fortunes around in the space of 500 metres. The 31-year-old Boston-raised American came to China with doubts about her form, having broken her wrist at the Trofeo Alfredo Binda World Cup race in Italy only six weeks prior.
In 2010, the Tour of Chongming Island stage race doubled up with the fifth round of the UCI Women's World Cup, also held in Chongming. The formula worked well, and the "partner race" concept is now in its third successive year. 2012 sees the World Cup race start in Shanghai's Pudong New Area for the … Continue reading
Melissa Hoskins secured overall Tour of Chongming Island victory today and handed her GreenEDGE-AIS team its first ever stage race win in Asia. Only three seconds separated Hoskins from incumbent yellow jersey Monia Baccaille (MCipollini Giambenini) at the start of today's 79.2km 'Shanghai East Beach – Chenjia Town Cup' circuit race, but Hoskins gathered enough … Continue reading
Former two-time Italian National Road Cycling Champion and 2011 Tour of Chongming Island third place-getter Monia Baccaille (MCipollini Giambenini) stole the show in today's 118.4 kilometre 'Chongming New City Cup' stage.
Melissa Hoskins (GreenEDGE-AIS) claimed her first professional road cycling victory in Asia today, after decisively winning the 73.4km opening stage of the three-day UCI Tour of Chongming Island stage race in China.