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Turtle Inn Resort
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TravelPod Member ReviewsTurtle Inn Resort Boracay
I stayed here about 5 days while visiting Boracay. It's a very nice with large rooms and friendly staff. It's quite a long walk to station 1 and 2, but the upside is that it's a quiet area. I bought a t-shirt from the inn and still wear it proudly (good quality t-shirt also, by the way :)).
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Historical Traveler Reviews Turtle Inn Resort Boracay
Best place to stay on Boracay
We stayed at Turtle Inn for 5 nights during our honeymoon in September. The owners of the guest house are extremley friendly and gave us a very warm welcome. During our stay there they made every effort to help us, including recommending an excellent contact on the island to take us on a boat trip. The rooms are very clean and spacious. With excellent air con, cable tv and a very reasonably priced mini-bar, what more do you need! The area in which the Inn is located is definitely the nicer end of the island and I would highly recommend staying at Turtle Inn.
My partner and I stayed in Turtle Inn for 9 nights in September. We were on an 8 month trip and stayed in many places over that time and Turtle was by far the best. The staff are all so kind and helpful and will do anything for you. It was like staying with family. The hotel is beautiful, and on Boracay which can feel a little overcrowded you really feel like you are away from it all, while still being only a 2 minute walk from the beach and amenities. There is a real sense on space around the resort. While we were there the restaraunt was still being completed but it did not affect our stay in the slightest, and will be fantastic when finished. The beds are huge and so comfortable, even the linen was luxurious. There is an excellant mini bar in the room with everything you could want - and Troy is on hand to share a drink with you if required!! We booked by email and were expected when we arrived with a lovely welcome drink. We even had complimentary breakfast on our balcony a few times. I could not recommed Turtle Inn highly enough - We only have one complaint and that is that we could not stay longer.
Perfect Vacation!
It's been almost a week now since i got back from a wonderful trip in boracay. i am just glad that i never hesitated to spend 4 days of my vacation to a place i call PARADISE! Sure there were a lot of good things happened with this trip and one was staying at Mr. T's TURTLE INN. My friends and I were so tired from the trip and first thing that we could think of was to get a good rest on the first day... and fortunately we did. I was so surprised to see our hotel room. It was huge! It reminded me of my stay in Marco Polo Hotel because it looked almost the same... big nice beds, clean bathroom and if i am not mistaken we were on the top most floor. Yes.. it was like staying in a 5 star hotel but it was freakingly cheap! The staff were just extremely accomodating especially the owner himself, TROY. He made our vacation so perfect! He had good recommendations. He brought us to cool party places the first night and even went sailing, island hopping and snorkelling (my favorite) with us on our third day. It was my 3rd trip to bora and that was the only time that i had so much fun. THANKS to TROY, Jenny and the rest of Turtle Inn staff. I would defenitely stay again with you next time!
So if you people out there planning a trip to Boracay.. Stay at Turtle Inn. SURE you'll have the best of everything!!!
Just loved Turtle Inn
Thanks to Korean Chu Suk (Oct 5-7). We were able to have a long vacation. My colleagues and I didn't waste time to book a flight all the way to Bora. We wanted to be refreshed and relaxed in this 3-day vacation. We wanted to have fun and just spend the time of our lives without thinking loads of work. We just wanted to get away from a city life even in just a couple of days. So we did. But the big question there is, HOW on earth can we satisfy our wants? Definitely, we have to start from the resort that we're going to stay in. Checking good resorts made us worried and exhausted.. what if we'll just get disappointed when we get there? How are we suppose to make the best out of that worst situation? Whatever be the thing is... we NEED to get a resort that would accomodate us well in a very reasonable price. AND thank God, we had it!!!...
We're damn glad! Our stay in Boracay would have not been that superb, worth spending and fun if not of our resort --- THE TURTLE INN ---
The accomodation was more than what we expected. All the staff there were friendly, sincere, service-oriented, courteous and more than willing to extend whatever help they may offer. Jenny ( the beautiful sister-in-law of the owner) welcomed us with a fresh orange juice and showed us all the room amenities. There was even a daily housekeeping. She was too kind to ask what more we need and would delightfully grant us. She's simply the best. Take note also guys that the towels and bedsheets are of high quality and super white you wouldn't even want to unclean them.
Daddy Troy (we call him daddy co'z he seems to be like a father to us, making us feel protected and being taken cared of whenever we're out to party @ night),THE RESORT OWNER, showed us around Boracay and introduced us to the best places where we can get groovin'. He even bought us some drinks and accompanied us to different bars where we can have a lot more fun! In fact, we kissed the loneliness goodbye in 3 straight nights ! We rocked peeps, I'm tellin ya that! Not only that, TURTLE INN always sees to it that we're more than comfortable in our 3-day stayed there. The room HAS it all.
Home away from home
We have just returned from a 4-day stay at Turtle Inn, and all I can say is that, it seems we actually never left home. The room was too comfortable, to the point that it was too dificult for us to get up in the morning, we practically wanted to sleep all day. Our room was furnished with a queen size orthopedic bed, so the frequent backpains we usually experience when booking in most hotels, was totally not an issue. To spice up more on the comfort of our room, first class Canadian linens where used, which were all immaculately white! Bath, hand and face towels were provided and changed daily, and like the pillowcases/sheets, they were all immaculately white. Our room had a brand new aircon, tv and ref. It also had a minibar, and items were all reasonably priced. The room was also provided with sachets of 3in1 nescafe, and an electric water boiler, should guests wish to have coffee at anytime of the day, and they were free of charge!
But, it wasn't just the comfort of the room that made me say that it was a HOME AWAY FROM HOME. The best thing about Turtle Inn was the personal touch that Troy, the owner, gave to his guests. My daughter and I arrived on a Wednesday, and next morning, I asked Manang Merlie, the chambermaid, where Troy was, as we wanted him to help us with our boating trip. Manang Merlie replied that Troy was still asleep as he waited for us all night, as no one in the resort ever noticed us come in at around 10 pm of Wednesday. He waited till almost past 1 am, and was worried howcome we weren't back yet when we said that we were just going out to have dinner. And when it seemed that it will take forever for us to return, did he ask Manang Merlie to go up and check us in our room. Even Toto, Troy's handyman and Manang Merlie waited all night with Troy.
Our stay at Turtle Inn wasn't a package, and the rate quoted to us just covered the accomodation. But on the morning we arrived, we were welcomed with 2 tall glasses of orange juice. Not just that, on our next morning, we were served with eggs, strips of bacon, slices of bread and coffee for breakfast. And on our last night, Troy invited us to have shakes at a nearby resort. And after having our shakes, he treated us for a few more drinks while chatting with a few of his foreigner friends. He introduced us to Jen and her boyfriend Joey, the owner of Red Pirates.
Saturday was our departure. As I have said, our trip wasn't on a package, but still upon checking out, Troy informed us that Toto, Troy's handyman, will be seeing us off at Cagban port. To my surprise, even Frankie, Troy's son, went along, infact he even helped Toto with our luggage! Where in the world will you ever see this kind of hospitality and care for their guests? I'm sure only at Turtle Inn!!!
Though the resort isn't along the beachfront, it is just a 2-minute walk away from the beach. The pathwalk is paved and well lighted, and the neighbors are very friendly and courteous. Infact there was no day that the neighbors won't greet us with a smile and a good morning/afternoon/evening.
It was our first time in Boracay, and there was never a time that we visited a vacation spot twice. But we will definitely be coming back sometime in March or April! And what's more definite is our 2nd stay at Turtle Inn! See you guys (Troy, Frankie and the rest) in 6 or 7 months!!!
Truly a wonderful place
So my friends and I were just finishing up a trip in South East Asia with our last week planned for the Phillipines. We planned on heading to Boracay first, and ended up finding this place on the internet. It had offered a great price (If I remember correctly it worked out to 10 dollars a person - ish) for what it was offering and so we initially booked it for about 3 nights (just in case it didn't meet our expectations).
However upon arrival there we soon extended our stay for the whole week. We ended up flying into Boracay a bit late and landed in a bit of rain, but ended up finding someone waiting for us at the airport. It was great to have that luxury especially with the route that we had to take to get from Caticalan Airport to Boracay Island. I'm sure that without him we would've ended up getting lost along the way. We ended up taking a 'motor-taxi' from the airport to the dock, where we caught a boat to the island. That was an experience in itself, with us having to change boats, in the middle of the night, in the middle of the sea. But we made it safely to shore and with the help of the guy from the hotel we managed to manuveour our way in a 'motor-taxi' to the hotel. The road in was a bit funny, especially with us having to guide ourselves in past residential routes to get to the hotel, but the site that we came across was amazing. I can only describe it as a 'diamond in the rocks', with its white exterior, complemented by a huge sign at the top, saying 'Turtle Inn'. (One thing to add, is that just cause a place is placed in a residential area it doesn't mean its lacks quality - we found a similar place in Bali when we were there). But yeah, it was quite an amazing place to come to after a long trip from Singapore to Caticalan.
Mhalen and Troy, the owners of the hotel, were just amazing as well, and they even upgraded our room to a place with two queen beds for just a fraction of the price more. The rest of week we were treated like family, with Mhalen lending us her cell-phone in case we got lost, to them taking us out for drinks and such, to even having a bbq thrown for us the night before we headed back home. You know some people might say that this is a three-four star hotel, but the people make it five-star all the way. I would definately head back there again to see how progress on the hotel is going, and to enjoy that kind of hospitality again.
Not for Families
We stayed there last month. The hotel is not kid friendly. You can not let child out on verenda either in top rooms as they can fall or bottom rooms as no place for them, no railings. Construction at hotel and next door makes for noise. Pathway is paved but thru area that is not comfortable to walk at night. From other comments, it is good hotel to go to if you want to drink but not for family. We were not happy there.
Boracay Blast 2006
I have been looking for affordable accomodation a month before our trip to boracay and came across turtle inn..after asking my boyfriend, Allan, if the place was OK with him, on agreeing, i immediately booked a room for us.
Our flight to Kalibo was 8.55 am but got delayed for a few minutes, i was worried that nobody will pick us up since i told them that we would be arriving at 9 am, surprizingly, when we landed and was about to go to the baggage claim, there it was! my name on a card, the guy said our "companion" is outside the shed waiting for us.and that was about 10.30 am already..i was soo relieved.So turned out his name is June..He was very helpful all the way, carrying our luggages and making sure we are ok..So sweet!
Upon arrival we were welcomed by Jenny (June's wife) and led us to our beautiful room (room 10)..And there came our welcome drinks (ponkana juice, if im not mistaken...my fave!)
We had a little patio but couldn't stay out cuz its raining or showering..
After taking a rest we were off to see the island and the owner, Troy, was very helpful..giving us advices and tips on where to go and what to do.He even said he'll send someone to pick us up if ever we got lost and all we need to do is call them. Fortunately we didnt get lost nor got wasted ;)
The place is very easy to find, even if it's a little inside, since they have a road constructed uniquely so we could find our way.
We stayed for 4D/3N, and our 2nd day after island hopping we were given a basket of fruit, very sweet indeed. We met troy's wife mhalen on the 3rd day and the couple suggested us to go to pukka beach and was kind enough to lend us 2 towels in case we go there. We didn't cuz we did our water sports that day (last day) but we were grateful for the kindness really..
Before leaving we asked jenny to get us someone to pick us up on checking out, and that morning, there was a tricycle then waiting for us, Jenny sent us and asked her hubby to help out (which btw was mixing cement) and he did stop immediately and help us out , apologizing for the dirty hands..
The entire staff are soo accommodating you will definitely feel at home..Except, it was mentioned that they're new and true indeed, the room we had are lacking some stuff still but im sure they are working on it..Didnt bother me much since i came to boracay for fun and i soo much enjoyed staying there that i might stay with them the next time i go there. Cant wait til u have they have the swimming pool ready..
Thanks everyone for making our stay Superb!
Amazing people, beautiful hotel!!
My friends and I came across turtle inn on a website and we booked it immediately. The price was far better than most other hotels and yet the hotel seemed to offer everything that the others one did. We arrived a few hours late in Caticlan and were very suprised that someone was waiting for us! We dont know what we would have done without him. It was late at night and raining. We took a tuk tuk ride to the pier, a little boat and crossed over to a bigger boat while in the water in the darkness. I must say it was a scary experience for us being in the Philippines for the first time but having someone with us made it comforting and he helped so much with getting our luggage there in one piece. Expecting the worst we arrived at a beautiful hotel in Boracay. We were greeted by the staff and given umbrellas right away. Troy the hotel manager upgraded our room for us for a few extra dollars. A very spacious room with two queen size beds, amazing mattress, pillows and sheets, A/C, T.V that had almost 100 channels, refrigerator and shower and not to forget a 20ft balcony with tables and chairs where you could hang out. As the restaurant was not yet finished at the hotel they ordered in pizza for us and gave us tips and advice for the island and diving.
As the days went on we became really close with the hotel staff. Troy would tell us where to go and would arrange for everything for us. Mhalen his wife was an absolutely amazing women. She would come shopping with us and even threw us a wonderful BBQ one day. They would take us out for dinner and even show us the good nightspots. As they were just in the process of adding phones in the room it was hard for my boyfriend to call me. Mhalen would offer me her cell phone everyday where he could call me and talk to me for hours. The first day she even gave it to me just in case we got lost on our way back! We had originally booked three days just to make sure we liked the hotel but we ended up staying for 10! And not just that, we got an additional discount for staying that long. It really made no sense to go anywhere else and we were very happy there.
The people here really went out of their way to make you feel at home. After travelling through Indonesia, Singapore, Malaysia and all of Thailand I would have to say that the Philippines really touched my heart. It was the first place where I felt at home and not like a tourist and I have Mhalen and Jennys family to thank for that. I felt like I was staying with a relative that would take care of me no matter what happened. As beautiful as the hotel was at the end of the day its the people that make your trip memorable. The plans for the hotel sound great and Im eager to get back soon to see it. The restaurant sounds like it will be ready soon and the plans for the swimming pool and waterfall sound amazing. Best of luck with everything Troy and Mhalen and hope to see you soon!!!
With love Vicky
More than expected, from the Turtle Inn!
I was planning a scuba diving trip to the Philippines, and after finding a diving shop to dive with, I had asked them for hotel / resort reccomendations that are close to the dive shop. I was then given the name of Turtle Inn Boracay.
When I went to the website, still in progess, I did not find an easy way to book and pay for the hotel, so I made a call to the Philippines and spoke with the manager. She directed me to a way to do so from antoher web site, however, since I was making last minute accomodations, I was not able to pre pay for the room. Still, it was reserved for me.
When I landed in Manila, I again called the manager and indicated what flight I would be arriving in Caticlan with. She said she would have someone there to pick us up.
The flight to Caticlan was late, yet, on arrival there indeed was two persons with my name on a sign awaiting to carry our bags to the trike. A short ride, and short boat ride later we were at Turtle Inn.
We got the deluxe room, which offered a top floor and larger balcony. A nice view, and very private. It was clear that the resort was new and still being constructed in some areas. The rooms were clean, with comfortable beds, cable TV and a mini bar with very affordable prices.
When I was there in early July, 06, construction of the resort's bar and restoraunt was not yet finished however, the resort had a deal with a local restorant to be able to bring food to order as room service. A nice touch while still in construction. The customer service did not stop there. From laundry, to fresh bananas in the morning the resort staff took care of every need. The owner, Troy, introduced himself and also went out of his way to ensure all of our requests were met, from dining ideas to drinking holes.
The apparent partnership between Turtle Inn and Dive Gurus was great. Perhaps it was a friendship that had forged it first. Whatever the case, the two entities worked hand in hand to accomodate our needs. Troy had joined us for a drink at the bar located in the dive shop after a day of diving. Inexepsive drinks, good company, a wonderful tropical breeze and view of the sunset, with dinner provided by the Indian quisine located above the dive shop, the experience was absolutely spectactular!
I can not say enough good things about Turtle Inn Boracay and will surely stay there again in the future!
TripAdvisor Reviews Turtle Inn Resort Boracay
Travel Blogs from Boracay
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The Most Beautiful Beach - Agree to Disagree
... I wanted to deal with was "the itch" in the Philippines! So after walking up the beach for a bit and passing by the never-ending line of restaurants, bars, and hotels, I decided to head to the other side of the island (it is a 10-15 minute walk...this island is tiny!) and check out Bulabog Beach. I was happy to see it was not crawling with people and although the sand wasn't as nice, it was far more breezy (a great location for kitesurfing) so there was no ...
... that modern technology will arrive fast enough to be used before old technology destroys it all !!!!! In the afternoon we went for a shake at Jonah's and a walk and stayed on the beach to swim and chill. In the evening we went for a Mongolian buffet at Sun Villas and than Andrea talk to her father to congratulate him with his 70's birthday. 17th Our last day on the beach and we enjoyed it as much as possible. We had our usual shake at Jonah's and in the evening we had dinner at ...
Mindoro and Boracay
... is very big here and throughout the Philippines. The natural underwater beauty and shipwrecks (mainly from WW2) are what draws divers from all over the world. I have dived before but doing it now wouldn't be a good idea.
"A Ferry bad idea"
The one hour ferry trip back to Batangas is uneventful. Though a young South Korean woman opposite me nearly loses her lunch a couple of times. I keep muttering to myself, "bombs away!" when I think she is close. But she uses smelling ...
Thrill seeker
... view point. Quickly the massive group of animated people dispersed throughout the place some slipping on the wet floor in their haste but getting up without a fuss not wanting to miss out. We claimed what I think to be the best seats in the house, right at the front overlooking the bay and all the jumps. We had half shade half sun so we could switch in and out during the day to stay at the optimum temperature. It didn't take long for the bar to open and swarms ...


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Author Affiliations: Departments of Radiation Medicine and Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY (Drs Khan, Nair, and Kariapper); Departments of Radiation Oncology (Mss Mamou, May, Kwitny, Warnat, and Miller and Drs Bolton and Normolle), Statistics (Dr Schipper), Human Genetics (Dr Brewer), Internal Medicine (Dr Merajver), and Otolaryngology–Head and Neck Surgery (Dr Teknos), University of Michigan, Ann Arbor.
To assess the effect of combining tetrathiomolybdate therapy and radiation treatment (RT) on tumor growth in the mouse head and neck squamous cell carcinoma (HNSCC) model.
One million HNSCC cells were injected subcutaneously into the flanks of C3H/HeJ mice and the tumors grown to an average of 301 mm3 (day 0). Mice were randomized into 4 groups: (a) no therapy, (b) tetrathiomolybdate alone, (c) RT alone, or (d) tetrathiomolybdate + RT. Data from 3 experiments with these 4 groups were analyzed. A gaussian mixed model was fit to the initialized logarithm of the tumor size counts between days 7 and 16 (linear component), and growth rates were compared. Assays using 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyltetrazolium bromide (MTT) were conducted on HNSCC cells in culture with varying doses of tetrathiomolybdate.
Treated mice were given tetrathiomolybdate in their water and observed for clinical evidence of toxic effects associated with copper depletion as measured by ceruloplasmin assay. When tumor sizes reached an average of 535 mm3, mice receiving RT were given a single fraction of 750 rad (7.5 Gy), a dose determined in previous experiments to slow but not cure tumor growth, permitting an examination of interaction of radiation with tetrathiomolybdate.
Data from 3 separate experiments were analyzed. There were a total of 37 mice in the untreated group, 32 mice in the tetrathiomolybdate alone group, 38 mice in the RT alone group, and 46 mice in the tetrathiomolybdate + RT group. Ceruloplasmin assays showed that we had obtained adequate copper reduction throughout the experiments to inhibit angiogenesis with minimal toxic effects. The tetrathiomolybdate + RT combined therapy group of mice showed a statistically significant decrease in tumor growth compared with both the tetrathiomolybdate alone (P = .001) and RT alone groups (P<.001).
The combination of the anti-angiogenic copper chelating agent tetrathiomolybdate with RT improved local control of HNSCC in an isogenic mouse model compared with either therapy alone.
The effectiveness of radiation therapy (RT) to combat primary tumors is improved in animal models by the addition of anti-angiogenic agents.1- 5 Tetrathiomolybdate is a copper level–reducing drug developed for Wilson disease6 that has anti-angiogenic properties resulting from lowering copper availability.7- 9 Tetrathiomolybdate inhibits angiogenesis in multiple pathways without significant toxic or adverse effects. Previous research has shown that tetrathiomolybdate can be combined with RT to improve the efficacy of the RT in a Lewis lung high metastatic carcinoma mouse tumor model.10
Numerous studies have demonstrated that angiogenesis (formation of new blood vessels from preexisting microvasculature) is a critical step in the growth of primary and metastatic tumors.11- 13 This has important implications for the treatment of head and neck squamous cell carcinomas (HNSCC), where angiogenesis has been demonstrated to play an important role,14- 23 particularly in tumor response and local control after RT.22- 28 If angiogenesis is inhibited, tumors remain microscopic. The balance of numerous stimulators and inhibitors of angiogenesis determines whether angiogenesis is turned on or off.29 Inhibition of angiogenesis will require manipulation of multiple steps in this process. Tetrathiomolybdate inhibits angiogenesis by affecting several molecules involved in angiogenesis, including vascular endothelial growth factor, basic fibroblast growth factor, nuclear factor κB, and other well-known proangiogenic molecules.30- 35
To test the validity of the conclusions drawn in previous research on a lung cancer mouse model,10 we conducted experiments using tetrathiomolybdate and RT in a mouse model of human HNSCC. We postulated that it was reasonable to apply similar methods to these 2 different types of cancers because anti-angiogenic therapy targets the reasonably homogeneous microvasculature and not the tumor directly. It is also critical to understand the effects of the combination of tetrathiomolybdate and RT on human endothelial cells, as RT is a key component of primary and postoperative treatment of head and neck carcinomas, and there will likely be a patient group where the addition of tetrathiomolybdate will be tested.
The SCC cells used are head and neck cancer cells isogenic to C3H/HeJ mice. The SCC cell line was maintained in serial passage in vitro. Male, 6- to 9-week-old C3H/HeJ mice (Jackson Laboratories, Bar Harbor, Me) were used for experiments. The mice were acclimated and caged in groups of 5 or fewer and then were shaved 1 day prior to receiving radiation. All mice were fed a diet of animal chow ad libitum. They were anesthetized using isoflurane delivered through a ventilation chamber prior to all procedures and were observed until fully recovered.
The SCC cells were grown in cell culture and maintained with Dulbecco Modified Eagle medium with 4.5-g/L glucose and L-glutamine, 10% fetal bovine serum, and 1% penicillin/streptomycin. Cells were harvested from the culture using a trypsin-EDTA solution in Hanks balanced salt solution. After harvesting, these cells were counted on a hemocytometer and spun down in a refrigerated centrifuge at 4°C at 200g. The tumor cells were suspended in phosphate-buffered saline at a concentration of 107 cells/mL, and the suspension was placed on ice. The upper dorsal surface of the leg of each mouse was injected with 106 cells in 0.1 mL of phosphate-buffered saline after cleaning the injection site with ethanol.
Using the same technique as previously determined,10 initial experiments with 10 mice were carried out to determine the average volume of water consumed per mouse per day. The volume of water imbibed in each 24-hour period was measured for each cage, with each cage holding 5 mice, and the volume per mouse determined. The concentration of tetrathiomolybdate in the water bottles was then calculated to deliver the appropriate dose of tetrathiomolybdate. Freshly mixed tetrathiomolybdate was placed into the water bottles each day.
Mice receiving RT were irradiated with a gamma-cell 40 cesium irradiator (100 rad/min [1 Gy/min]). A specially designed lead jig and shield apparatus was used to immobilize and shield the mice while exposing the leg to be irradiated. No anesthesia was necessary.
Blood was collected from mice treated with tetrathiomolybdate by anesthetizing the mice with isoflurane and performing cardiac puncture. Blood samples were centrifuged at 3000g at 4°C, and serum samples were collected and frozen at –20°C until the assays were run.
The ceruloplasmin levels were measured per a standard assay.36 Aliquots of 25 μL of serum from each mouse were placed into 2 tubes, and 375 μL of 0.1M sodium acetate buffer (stored at 4°C; pH, 5.0) was immediately added. Tubes were placed in a 30°C water bath. After 5 minutes, 100 μL of o-dianisidine dihydrochloride (7.88 mM; Sigma-Aldrich, St Louis, Mo) reagent (preincubated at 30°C) was placed into each tube using a pipette. After 30 minutes (A30), 1 of the 2 tubes for each group was removed from the water bath, and 1 mL of 9M sulfuric acid was added to quench the reaction. After 45 minutes (A45), the second tube was quenched, and the absorbance of both tubes at 540 nm (A30 and A45, respectively) was analyzed using a 1-cm path length cuvette in a spectrophotometer. The ceruloplasmin concentration in international units was calculated by the formula ceruloplasmin oxidase activity = (A45 − A30) × 0.625 IU/mL.
In vitro experiments were carried out on the SCC cell line using a 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyltetrazolium bromide (MTT; Sigma-Aldrich) proliferation assay. The MTT reagent stains live cells, and the 595-nm absorbance correlates with cell number. Cell proliferation MTT assays were carried out for 4 days (days 0, 1, 2, and 3) with daily measurements of absorbance. A flat-bottomed, 96-well Falcon microtest tissue culture plate was used for each time point, with 6 replicate wells used for each tetrathiomolybdate concentration. One thousand cells were added to each well. On the following day (day 0), tetrathiomolybdate was added to bring the concentrations to 0, 0.001, 0.02, 0.01, 0.1, and 1.0, and 10 nM/well. On days 0 to 3, 50-μL aliquots of MTT were added to each well using a pipette again, and the plate was incubated for 2 hours at 37°C. Aliquots of 100 μL of dimethyl sulfoxide were added to each well using a pipette, and the plates were agitated for 5 to 10 minutes. The absorbance at 595 nm was read by a Dynatek MR 5000 plate reader (Dynatek, Chantilly, Va). An absorbance titration curve at 595 nm was generated using data from the MTT assay carried out with a 10-fold increase in cells from 0 to 1 million cells.
Data from the 3 experiments each containing 4 treatment groups were analyzed separately. A gaussian mixed model (SAS PROC MIXED; SAS Institute, Cary, NC) was fit to the initialized logarithm of the tumor volumes. The logarithm of the tumor volumes were initialized by subtracting the day 0 log tumor volume for each mouse. Although the experiments were run out to day 21, the growth curves for the log tumor volumes were approximately linear only between days 7 and 16. After initial analysis of mean plots, it appeared that the growth curves leveled off for the tetrathiomolybdate group after day 16, and thus a linear model was inappropriate after day 16. The model was fit to the initialized log tumor volumes between days 7 and 16, and the growth rates were compared. Separate intercepts and slopes for each of the 4 treatment groups were used as predictors in the model. At the experiment level, a random intercept for each experiment was included to account for variation between experiments, and at the mouse level, a random slope and intercept were included for each mouse.
Three experiments were carried out in succession using 80 mice per experiment. One million SCC cells were injected into the flanks of C3H/HeJ mice and tumor volumes allowed to reach an average of 301 mm3 (mean ± SD values of 304 ± 82, 314 ± 71, and 286 ± 52 mm3 in experiments 1, 2 and 3, respectively). On this day (day 0), the mice were randomly separated into 4 treatment groups: (a) untreated, (b) tetrathiomolybdate only, (c) RT only, and (d) tetrathiomolybdate + RT. The number of mice for each treatment group for experiments 1, 2, and 3 were, respectively, (a) 10, 11, and 16; (b) 10, 10, and 12; (c) 11, 16, and 11; and (d) 11, 17, and 18.
Radiation was delivered to tumors in groups (c) and (d) on the same day that the tumor volumes averaged 535 mm3 (mean ± SD values, 546 ± 172, 557 ± 201, and 502 ± 110 mm3 in experiments 1, 2 and 3, respectively). A dose of 7500 rad (7.5 Gy) was selected for RT because this dose was shown in previous experiments10 to inhibit tumor growth but not produce cures, permitting analysis of the interaction of RT and tetrathiomolybdate.
Tetrathiomolybdate therapy was continued for the duration of the experiment in groups (b) and (d). As mice exhibited clinical signs of illness due to copper depletion, the doses of tetrathiomolybdate were adjusted as needed throughout the experiment. In experiment 1, groups (b) and (d) began treatment on day 0 with an initial dose of 0.9 mg per mouse per day of tetrathiomolybdate and on day 2 were switched to 0.45 mg per mouse per day for the duration of the experiment. In experiments 2 and 3, mice in groups (b) and (d) received an initial dose of 1.1 mg per mouse per day of tetrathiomolybdate on day 0 and were switched to 0.6 mg per mouse per day on day 2 for the duration of the experiment. The effectiveness of the tetrathiomolybdate doses was assessed by measuring the copper level (reflected in the ceruloplasmin levels). Between days 16 and 21, the remaining mice were killed by carbon dioxide overdose.
Our experimental data show that tetrathiomolybdate and RT in combination can slow tumor growth more effectively than either treatment alone compared with untreated SCC tumors (Figure 1). The results were the same whether we analyzed all mice or excluded mice with severe ulcerations. The data for the full analysis (all mice included) are summarized in Table 1. The log tumor volumes were approximately linear from day 7 through day 16, which is when the statistical model was applied. All 3 treatments—tetrathiomolybdate, RT, and tetrathiomolybdate + RT—caused significant reduction in tumor growth compared with untreated tumors (P<.001, P = .002, and P<.001, respectively) (Table 2). The tetrathiomolybdate + RT groups of mice showed statistically significant decrease in tumor growth compared with both the tetrathiomolybdate alone (P = .001) and RT alone groups (P<.001) (Table 2).
The logarithm of the initialized tumor volumes vs days of treatment. A total of 106 squamous cell carcinoma cells were injected into the flanks of mice and grown to an average volume of 301 mm3. Mice were sorted into respective groups, and tetrathiomolybdate (TM) regimens were started if appropriate. Radiation therapy (RT) in RT and RT + TM groups was started when tumor volumes averaged 535 mm3. For each experiment, the logarithm of tumor volumes initialized for the starting tumor volume on day 0 (A) and corresponding surviving mice (B) were plotted against time. The doses of TM given to the mice are detailed in the "Results" section.
The tetrathiomolybdate alone group appeared to have a more marked slope decrease after day 16, making that curve nonlinear after day 16 (Figure 1). Growth curves for the other groups remained approximately linear after day 16. There were so few data points after day 16 that no statistical significance could be obtained for this late decrease in this part of the tetrathiomolybdate alone curve. For this reason, the statistical analysis included only days 7 through 16 (Table 1 and Table 2) because this was the region where a linear effects model would apply most accurately.
We conducted further experiments to examine the effect of tetrathiomolybdate on the growth of SCC cells in vitro, including MTT assays to examine the growth of tumor in vitro (without a microvasculature). The SCC tumor cells were grown in untreated microtiter wells or in wells containing media treated with various concentrations of tetrathiomolybdate. The MTT assay absorbance data show that the levels of SCC cells on days 0, 1, 2, and 3 showed no statistical difference between all tetrathiomolybdate concentrations tested (0nM-10nM) and untreated SCC cells (Figure 2).
Analysis of tumor cell number by the 3-(4,5-dimethylthiazol-2yl)-2,5 diphenyltetrazolium bromide (MTT) assay. Absorbance levels corresponding to number of squamous cell carcinoma cells on days 0, 1, 2, and 3 showed no statistical difference between all tetrathiomolybdate (TM) concentrations tested (0nM-10nM). Error bars represent standard deviations.
Ceruloplasmin assays were also carried out on serum samples collected from representative SCC tumor-bearing mice treated with tetrathiomolybdate run from the same batch of mice used during each experiment, and we were able to show that the ceruloplasmin levels (and therefore copper levels) were decreased appropriately in the tetrathiomolybdate-treated mice (Figure 3).
Ceruloplasmin assay curves. Serum ceruloplasmin levels (as represented by the average absorbance at 540 nm) were measured at various time points in at least 2 tetrathiomolybdate-treated tumor-bearing mice in each group. As a comparison, the top curve (untreated) represents the baseline measurement of ceruloplasmin from 5 tumor-bearing untreated mice.
We show herein that the combination of RT with the multiple-target, anti-angiogenic, copper depletion therapy, tetrathiomolybdate, decreases the growth of tumors in an HNSCC mouse model. This combination therapy is superior to monotherapies of tetrathiomolybdate or RT. Tetrathiomolybdate is the most potent copper level reducing agent known and has been used for over a decade in the treatment of the copper storage disorder called Wilson disease,37 for which there is now an extensive clinical experience with tetrathiomolybdate as a copper-lowering drug.37 Tetrathiomolybdate forms a stable tripartite complex with copper and protein, creating in patients a negative copper balance immediately. The safety and antitumor effects of tetrathiomolybdate therapy alone in patients with solid tumors have been evaluated in a phase 1 clinical trial,38 in which tetrathiomolybdate was shown to impair angiogenesis but leave other copper-dependent cellular processes largely intact, so that no significant clinical toxic effects occur.
The data collected have demonstrated that tetrathiomolybdate treatment can slow the growth of SCC tumors in vivo. We conducted further experiments to support the case that this slowing of tumor growth is owing to the anti-angiogenic action of the drug (via depletion of copper) and not due to direct effects of the drug on the tumor. The MTT (tumor cell proliferation) assays showed that the numbers of SCC cells on all days tested were not significantly different. In other words, SCC cells exposed to all tetrathiomolybdate concentrations tested (0nM-10 nM) were not significantly different from each other over time, and none was significantly different from the untreated SCC cells. Previous estimates (calculations) from patients treated with tetrathiomolybdate showed that the 0.01nM to 0.1nM tetrathiomolybdate concentrations are similar to those seen in cancer cells in vivo (unpublished data, 2004). In the MTT assays reported herein, tetrathiomolybdate had no effect even at 1000 times those levels in vitro. This finding supports the concept that it is the copper depletion action of tetrathiomolybdate that slows tumor growth in vivo, accounting for its known anti-angiogenic effects on endothelial cells and not direct action on tumor cells.
Several studies support the use of anti-angiogenic agents with RT.1- 5 A problem with several of the agents under study today (for example, anti–vascular endothelial growth factor antibody therapy) is that they attack only 1 anti-angiogenic target at a time. Over time, tumor cells have been known to evolve the ability to secrete several pro-angiogenic molecules, therefore possibly rendering a therapy directed against only 1 target useless. One envisioned way around this is to use a "combination" therapy with multiple anti-angiogenic agents at the same time, as has been done somewhat successfully with some chemotherapeutic agents. Therapy with tetrathiomolybdate presents exactly this scenario but within a single agent. Depletion of copper by tetrathiomolybdate interferes with multiple angiogenic factors at once, making it an ideal multiple-target anti-angiogenic agent.30 This multiple-target anti-angiogenic mechanism for tetrathiomolybdate has also been recently demonstrated in angiogenic in vitro systems relevant to HNSCC.39 The fact that copper depletion therapy facilitated by tetrathiomolybdate has been apparently safely combined with RT in 2 different tumor mouse models (lung cancer10 and the present HNSCC model) supports the notion that tetrathiomolybdate targets the tumor microvasculature, not the tumor itself, and therefore should be applicable to multiple tumor types. The fact that tetrathiomolybdate can be successfully combined with RT to increase the suppression of tumor growth in a HNSCC mouse model has significant implications for the treatment of head and neck cancers, where radiation is a mainstay of therapy for many stages of this cancer, including definitive and postoperative treatment.
Correspondence: Mohamed K. Khan, MD, PhD, Department of Radiation Medicine, Roswell Park Cancer Institute, MRC Room 224, Elm and Carlton Streets, Buffalo, NY 14263 (firstname.lastname@example.com).
Submitted for Publication: May 12, 2005; final revision received July 20, 2005; accepted August 1, 2005.
Financial Disclosure: Drs Brewer and Merajver have an equity interest in Attenuon LLC, San Diego, Calif, and are paid consultants for this company. Attenuon has licensed the anti-angiogenic uses of tetrathiomolybdate from the University of Michigan, Ann Arbor.
Funding/Support: Research for this article was supported in whole or in part by a Specialized Programs of Research Excellence (SPORE) Grant in Head and Neck Cancer–National Institutes of Health/National Cancer Institute/National Institute of Dental and Craniofacial Research (NIH/NCI/NIDCR), grant 1P50 CA/DE97248-01 (Drs Teknos and Merajver), and NIH R21 grant 7R21CA096314-02 (Drs Khan, Nair, and Kariapper). In addition, Dr Merajver was supported in part by grant CA 77612 from the Burroughs Wellcome Fund and the Breast Cancer Research Foundation; Mss May, Kwitny, and Warnat were supported in part by University of Michigan Summer Research Opportunities grants.
Acknowledgment: We thank Robert Dick, BS, for the supply of tetrathiomolybdate for the studies.
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What is in this article?:
- 6 Practices to Get Your Corn Crop Off to a Good Start
- Seeding rate, depth
- Hybrids
More About:
Seeding rate, depth
3. Adjust seeding depth according to soil conditions. Plant between 1½ and 2 in. deep to provide for frost protection and adequate root development. Seeding depth should be monitored regularly during the planting operation and adjusted for varying weather and soil conditions. Irregular, especially shallow, planting depths contribute to uneven plant emergence, which can reduce yields. See last week's newsletter article for more on the importance of avoiding shallow planting depths.
4. Adjust seeding rates on a field-by-field basis. Adjust planting rates by using the yield potential of a site as a major criterion for determining the appropriate plant population. Higher seeding rates are recommended for sites with high-yield potential with high soil fertility levels and water holding capacity. OSU plant population studies conducted from 2006 to the present suggest that on highly productive soils, with long-term average yields of 190 bu./acre or more, final stands of 33,000 plants/acre or more may be required to maximize yields.
Lower seeding rates are usually preferable when droughty soils or late planting (after June 1) limit yield potential. On soils that average 120 bu./acre or less, final stands of 20,000-22,000 plants/acre are adequate for optimal yields. On soils that average about 150 bu./acre, a final stand of 30,000 plants/acre may be needed to optimize yields.
Seeding rate can be cut to lower seed costs but this approach typically costs more than it saves. Most research suggests that planting a hybrid at suboptimal seeding rates is more likely to cause yield loss than planting above recommended rates (unless lodging becomes more severe at higher population levels) and harvest delays occur. When early planting is likely to create stressful conditions for corn during emergence, e.g. no-till in corn residues in early to mid April, consider seeding rates 10-15% higher than the desired harvest population. Follow seed company recommendations to adjust plant population for specific hybrids.


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I am very interested in hearing everyone's story about how they became Muslim! How did you start learning about Islam? How long did it take you to decide to revert? I want to hear all the details!
For people who were raised Muslim, was there a time when you didn't really practice? If so, what made you start practicing? How did your parents influence you?
I usually like to put more personal posts like this on the private board, but I thought some of our non-Muslim friends, as well as those who are considering reversion might find this post interesting and useful.
One of the first things I learned after I took my shahadah is that every Muslim - and I mean every single Muslim I have ever met - loves a good reversion story!!
We'll start with mine...
The first time I ever heard of Islam was on September 11, 2001, or the 12th or whenever is was the Al Qaeda ended up claiming responsibility. I didn't really get it, you know? I thought the Taliban was a person. Anyway, it was not a very good introduction.
Something has always drawn me to Islam, though. I read the books that were made from journals of a Saudi princess. She spoke about sex slavery and the culture of misogyny that is so prevalent in Saudi, but she also spoke about abaaya, hijab and niqab. She hated them and felt that they were oppressive. When she traveled abroad, she would not wear them and her husband was okay with this. Very interesting books, but it was not a good introduction to the concept of hijab, so I completely bought into the whole oppression of hijab thing.
I met my husband while I was on exchange in France when I was 17 years old. This was not too long after the ban of the hijab in French schools, etc, and there was this one Muslim girl at my school who I would always see putting on her scarf on the bus as we left school. I remember wondering to myself if her father would beat her or something if he knew that she was so casual and careless about putting it on in front of all those strangers and I secretly applauded her "rebellion."
When I returned to the States I only had one semester left to do and I took a psychology class with a teacher I really liked and respected. He also taught two courses about the Middle East. One day I walked into his classroom and I saw some notes written on the board, one of which said:
Hijab, or headscarf, is rarely forced and is not a form of oppression.
And I was just kind of like, "Oh... well, okay then!" and that was that!
After that I became what I like to describe as a "militant agnostic." I was strongly attracted to Islam and I began to see the beauty of the headscarf and tried falteringly to explain to a French woman how it isn't oppressive (this was when I was with my aunt and uncle for a few months in NYC and she - the French woman - said "I get so angry every time I see someone wearing that! How could you force someone to cover up like that?"). But I wasn't anything - I prayed to saints and God and Jesus, I crossed myself, I found out how to pray Islamically, I researched Buddhism - everything.
Then I moved in with my husband (boyfriend at the time) in Alberta. One day we went to Superstore to pick up some things and - as always - we stopped to look at the books. There was this one called "A Year of Living Biblically" by AJ Jacobs. It is a memoir of the author during his year of attempting to adhere to the rules of the Bible completely literally. Now, we looked at the books at Superstore all the time and never bought them, but for some reason we bought that book that day and it changed our lives.
We read it aloud together and it was quite hilarious. My husb/oyfriend asked what I would think if he did the same thing with the Qur'an. I said I would do it with him!
So we started researching. We each had a copy of the Qur'an, so we tried to go through the translation and pick out all the rules so we could follow them for a year. Somewhere along the way, we realized that it wouldn't be hilarious like AJ Jacobs's book had been. It would actually make a lot of sense. We met with a few people from the local community and before we knew it we were in the masjid taking our shahadah and then a week later we were married!
We picked up the book in September or October or 2008. We came up with the plan in November. We reverted and married in February 2009. Alhamdulillah, I never would have thought that I would be led down this path, but here I am!
You may notice, I could not explain why we became Muslim. Honestly, this is a superficial story. Like, it wasn't because of the book that we became Muslim. The actual reason is too hard to explain. Something just felt right, you know? It made sense.


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DETROIT -- Justin Verlander takes the mound for the Detroit Tigers tonight at Comerica Park as the Tigers open a three-game series against the Minnesota Twins.
Verlander is 1-1 with a 6.95 ERA. Francisco Liriano (2-0, 1.29 ERA) will start for the Twins.
Here are the starting lineups:
Minnesota Twins
1. Denard Span, CF
2. Orlando Hudson, 2B
3. Joe Mauer, C
4. Justin Morneau, 1B
5. Michael Cuddyer, RF
6. Jason Kubel, LF
7. Jim Thome, DH
8. J.J. Hardy, SS
9. Brendan Harris, 3B
Detroit Tigers
1. Austin Jackson, CF
2. Johnny Damon, DH
3. Magglio Ordonez, RF
4. Miguel Cabrera, 1B
5. Brandon Inge, 3B
6. Ryan Raburn, LF
7. Gerald Laird, C
8. Scott Sizemore, 2B
9. Ramon Santiago, SS


text:
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- eCatalog
STERIPOD® TOOTHBRUSH SANITIZERs KILL BACTERIA so your toothbrush remains hygienic at all times. Each sanitizer contains a germ-killing tablet that provides continuous protection for up to 3 months. Just clip pod over your regular or electric toothbrush to avoid the spread of harmful germs. Great year-round, but especially useful during cold and flu season. Ideal for home, travel, office or gym. Made of BPA-free plastic. Set of 2.
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text:
CHOICES: 1. T Bill Bubble. 2. Crafty Cal. 3. Nachoordinaryguy.
FORTUS FORECAST: T Bill Bubble was edged at this level and claimed in his second start. Crafty Cal, cutting back in distance, might rally into the picture. Nachoordinaryguy, who had a wide trip and was outrun at this level in his debut, worked well since then.
CHOICES: 1. Thunder Perfect. 2. Romp In Home. 3. Buggs.
FORTUS FORECAST: Thunder Perfect, who might not have appreciated a sloppy track when outrun against higher-priced restricted claimers in his last start, drops to his lowest level. Romp In Home worked twice since finishing third against similar horses in his fourth start. Buggs, who is 1-for-12, was second in that race.
CHOICES: 1. Oh Whata Holiday. 2. Rock 'n' Roll Gal. 3. Implicate.
FORTUS FORECAST: Oh What Holiday, a Louisiana-bred who has won in open company, appears well placed in this restricted claiming group. Rock 'n' Roll Gal might be sharper in her third start since April. Implicate, who lacked stretch punch against similar runners 20 days ago, worked well since then.
CHOICES: 1. Eli's Deelite. 2. Very Possebull. 3. Thunder Affair.
FORTUS FORECAST: Eli's Deelite, who finished second at this level after having trouble at the break in her debut, likely will improve. Very Possebull finished in the money against similar horses in both of his races. Thunder Affair, a rare Louisiana-bred sired by a Kentucky Derby winner, has worked steadily for his debut.
CHOICES: 1. Noah's Humor. 2. Zeb. 3. Forest Run.
FORTUS FORECAST: Noah's Humor, a first-timer with a solid workout pattern, is bred to handle turf. Zeb, who showed little against tougher horses on dirt in his debut, has a pedigree for turf. Forest Run moves to claiming company in his second start after a long layoff.
CHOICES: 1. Cajun Prize. 2. Maltese Dog. 3. Rector.
FORTUS FORECAST: Cajun Prize, who hasn't raced in more than months, drops to his lowest level. Maltese Dog is well placed against $12,500 claimers. Rector takes a sharp drop in class in his third start after a layoff.
CHOICES: 1. Jazzy Jessy. 2. Albany Indian. 3. Miss Rufus.
FORTUS FORECAST: Jazzy Jessy, who had a wide trip against tougher runners in her return from a layoff, is well placed against restricted $25,000 claimers. Albany Indian has worked steadily since finishing sixth against similar runners at Gulfstream Park more than seven weeks ago. Miss Rufus finished second against similar runners in her last two races.
CHOICES: 1. Destiny's Gold. 2. Bayou Road. 3. Letem Run.
FORTUS FORECAST: Destiny's Gold, who finished a close third in a two-turn race against similar fillies in her second start, worked sharply since then. Bayou Road, who broke slowly in her debut and finished far back, worked well since then. Letem Run is a first-timer to consider.
CHOICES: 1. Ouragans Icon. 2. Gate Zapper. 3. Dixie Missile.
FORTUS FORECAST: Ouragans Icon, who finished in the money against similar runners in her last three races, might improve with blinkers. Gate Zapper edged the top pick for second last time. Dixie Missile will be running late.
CHOICES: 1. Indian Eddie. 2. Ontario Storm. 3. Malibu Rhythm.
FORTUS FORECAST: Indian Eddie, moving to claiming company after chasing tougher horses in his first two races, has a pedigree that suggests he'll handle turf. Ontario Storm, who showed little against tougher horses in his debut, is another who might appreciate a move to turf. Malibu Rhythm finished second at this level in a race switched from turf to dirt in his last start.
Today's best play: Indian Eddie (10th race).
Today's long shot special: Bayou Road (eighth race).


text:
Gala Drive-In
2215 E. Waterloo Road,
1 person favorited this theater
The Gala Drive-In opened in 1937 as a single screen and later was twinned. Car capacity was listed at 475. The Gala Drive-In closed in 1997 has since been demolished and is now a housing development.
Recent comments (view all 10 comments)
This is the site today:
It did park 475 cars and it was owned in the late 50's by OHIO THEATRE SERVICE.
Interesting that the housing development kept the Gala Name.
It's not a housing development but a commercial strip center. Several units for sale:
Thanks SiliconSam,but I think I will pass on buying a unit.Thanks for the info.
My Dad was the projectionist there for years. I miss going with him on Saturdays to fix speakers
Hey sher2112..do you have any pictures to share?
I have many fond memories of this Drive-In theater. It was a real gem. Sorely missed. Wish I had a decent photo of the place. Would even purchase one.
April 1st, 1949 grand opening ad as Gala Drive-In in photo section. It opened in 1948 as Sawyerwood Drive-In.
Just login to your account and subscribe to this theater


text:
The Cuyahoga Falls Parks and Recreation Department will offer adult tennis lessons beginning Wednesday, June 11 at the tennis courts at Falls High. Beginner classes meet from 6:15 -7:30 p.m. and Intermediate classes meet from 7:30 - 8:45 p.m. Beginner classes will teach you forehand, backhand, serve, net play, overhead, scorekeeping, doubles and singles play. Intermediates will focus on topspin, slice, singles and doubles strategy, drills and play. Cost of the three-week session is $40 Cuyahoga Falls Resident and $45 for nonresidents. Players should bring a new can of balls to the first lesson. Registration is being taken at the Parks and Recreation Office, Quirk Cultural Center or online at www.cityofcf.com\parksandrec. Pre-registration is required, no sign ups at the courts. For more information please contact the Parks and Recreation Office at 330-971-8225.
Event date:
Wed, 06/11/2014 - 6:15pm - Wed, 06/25/2014 - 6:15pm
Falls High Tennis Courts
Last changed 02/03/2014 - 2:49pm by richardson@cityofcf


text:
Make Money with Affiliate Marketing – Get the Traffic
I've recently delved into the world of affiliate marketing. I've seen the stuff for years, but never really gotten into it. The idea is simple enough, you get paid a "commission" for selling someone else's "product." These products can be anything from ring tones to dating sites to tuna fish. The key to all of this is getting traffic to the offer for less of a cost than what you are being paid – easier said than done.
I've studied this for some time now, but am far from educated on it. You could say I'm very low on the affiliate-marketing-street-smarts scale. However, here's a few of my very simple observations on the methods people use to get the traffic and make the moolah.
The Brute Force Method
Send as many people to your landing page as possible (even if it sucks) and a few are bound to complete the offer and earn you some coin. This is by far the easiest method. You don't have to have a good offer. You don't have to have a good sales/landing page. You don't have to have a good domain. You just have to have traffic.
This problem is, how do you get that traffic? One of the primary ways of generating traffic in affiliate marketing is through PPC advertising. Well, if your offer or your landing page stinks, you're going to be paying out the you-know-what for junk traffic. Operating at a loss isn't the most profitable position is it?
The only way this works is if you can drive hoards of traffic without paying for it – usually not an easy task. I read the blogs of many who have run this route. Their final conclusion is usually that affiliate marketing is a scam, no one makes money in it and Santa Clause is a lie.
The Look-At-Me-I'm-a-Fricken-Genious Method
Sending a few interested people to a targeted offer with a well done landing page is a much better way to go. This keeps your costs much lower as you're not paying for hundreds or thousands of clicks and your conversion rate higher as the people comming to your sales page are actually interested in what you have to offer. Lower advertising costs plus higher conversions equal higher profits.
But, if it were only so easy. This method requires two very important things (and two of the closest guarded secrets of affiliate marketers) – great keywords and a great landing page. Both of which take a lot of research and experimenting to get. That's more work than most people are willing to put into it and come to many of the same conclusions that the 'Brute Force' people come to.
Are you and idiot?
Obviously one of the two methods above isn't going to win American Idol (or County Star Idol or Canadian Mountie Idol.) The thing is, most people try to succeed in affiliate marketing by using Method A. Sure, they'll tell you that their keywords are targeted and they've spent hours stealing other people's landing pages. But, their stats say otherwise.
Which category do you fit into? Honestly, most of us are fooling ourselves. We have to look at this stuff objectively. Affiliate marketing is a tough business, but if you're really willing to put the work into it, it can pay off in big ways.
I'm spreadin' some link lovin' to my twitter followers. Props to Kate Brodock and Internet Marketing – Best Web Ezy. Want some linkage for yourself? Follow me on twitter!
June 19, 2008 1 Comment
I'm a Tweeting Twitter-er! (And Other Social Networker of Sorts)
I've given in. I've jumped on the tweeting bandwagon. Twitter, the not quite so new internet fad, has drawn me into its fold. My joining was prompted by the musings of blog giants Darren Rowse and John Chow, both of which are active twitter-ers. These guys use twitter as a social networking/marketing tool. They tweet regular updates through the day highlighting new posts and other random happenings (The other day Problogger let his 6,600 followers know that his son poked him in the eye.)
Stealing Their Ideas
Well if twitter works for my favorite full-time bloggers, then it works for me too. I know that social networking is a big key to driving traffic to your blog. This is an area that I need to work on some more. So here's my secret plan (shhh! Don't tell anyone!) <secret plan>…I'm investigating the social networkings of all my favorite blogging heavyweights. I'm looking to see what works for them, what sites are driving traffic to their blogs and what is generating the most reader interaction. Twitter is my first attempt at this. </secret plan>
Are you Following Me?
Become one of my faithful followers on twitter – WallerBlogDotCm. When you become of followers, comment below and I'll give you a shameless plug in a future post (free link love baby!)
June 4, 2008 4 Comments
Blog Income Report – May 2008
This is the first real monthly earnings report since this blog was resurrected at the beginning of this month from an 8 month hiatus. Year to date income for WallerBlog dot Com has averaged $47.03/month. Blog income for May was down from the YTD average, but has increased from April's $34.13.
Total Blog Income for May 2008: $37.32
Here is the breakdown:
- PayPerPost: $20.00
- Private Ad Sales: $7.00
- Google AdSense: $5.40
- TNX.net: $4.92
- Grand Total: $37.72
Blog income has decreased since the beginning of the year. This is primarily due to Google's PageRank update. My blog went from a PR 3 to a PR 0. This has effectively killed all income from Text-Link-Ads and LinkWorth. Before this month LinkWorth was my biggest money maker. That loss has been mitigated by the addition of PayPerPost.
Traffic Stats
Traffic this month is up to 1,294 page views from 608 visitors. The top traffic sources were:
- Google: 138
- Direct: 119
- StumbleUpon: 125
- Entrecard: 95
As usual the big G was the top referrer. The biggest surprise though was the 125 visitors from StumbleUpon. The Blogging Tips Carnival was Stumbled and received more traffic than any other post this month.
Determination is the key
Determination is the only thing that will make your small blog a success. Determination to write good content, determination to research monetization opportunities and determination to network to drive traffic to your blog. This month I am determined to work to gain quality backlinks in order to gain more green on my PagerRank. This will give me many more opportunities to increase this blog's income and get me closer to my goal of earning a full-time living via the internet.
June 1, 2008 No Comments


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The death of a 42-year-old woman found inside her car near DeLand has been ruled a homicide, according to the sheriff's office.
Bonnie Sue Burns, 42, was found dead inside her 2001 Ford Escort along the side of Magnolia Road in the Daytona Park Estates subdivision just northeast of DeLand.
According to deputies, a friend had been expecting Burns at her home and went out looking for her after she didn't show up.
"She's just laid over in the seat. She's blue. Oh my god," the friend told the 911 dispatcher.
The friend found Burns dead inside her vehicle and called authorities at 7:30 a.m.
The cause of death was not released.


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Who Feels Sorry For Bradley?
I think he had tunnel vision wanting the Pac fight..... He got it got a W (I don't think he won) and a nice payday but his options seem limited..... GB has everybody around his weight who means anything..... Do you feel for him and his predicament???
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The fights he is wiling to accept are without a doubt fan-friendly fights against the best competition available.....he is being his own man when others are simply "yes men".
I wish him well in securing a great fight but I don't feel sorry for him, I don't think he feels sorry for himself either - he is just telling it like it is.
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I would have if he didn't go around trashtalking like he won the fight like he did for a while even though the boxing world was roaring!
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I don't feel sorry for him but him begging for a Rios fight seems kinda sad or desperate.
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nobody does, fuck him
it would be fine if he didn't act like he actually won
accept the gift, call for a rematch, and leave it at that
but everytime he mentions his "win" he earns more hatred
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Im not a big fan but I definitely feel sorry for dude.
His claim to fame is a fight most people thought he shoulda lost. The commentators all also have some strange animosity towards dude and made the Pacman fight look like it wasn't close at all. Promoters also seem to not like him either lol dude is world champion right now and can barely get a single fight in. And now mosta the boxing world doesn't really like him either just because he stood up for himself and said what 90% of us woulda most likely said in that situation lol.
Soon as he gets another fight he should start running his mouth more and **** cause with all the people that TRULY don't like him and wanna see him get the loss they think he deserves, it would generate a lotta publicity and this guy could honestly be 100x the heel that Mayweather tries to be
la mala vida
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why would I feel sorry for someone who got the highest payday of their career AND a gift decision?.. No, I don't feel sorry.
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i don't really feel sorry for him..don't really care if he retires tomorrow or whatever he does with the rest of his boxing career. there are much better fighters out there to care about...shouldn't waste it on someone like bradley.
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Before Bill Goldberg was a famous wrestler, he was an All-SEC defensive lineman at UGA who played briefly in the NFL.
Goldberg, 47, is from Tulsa, Oklahoma, and was heavily recruited by the local colleges, including Oklahoma coach Barry Switzer, who would drink a "Crown on the rocks within five minutes" after coming over to Goldberg's house on visits.
How did Goldberg end up all the way at UGA? It had to do with an uncle who lived in Jacksonville, Goldberg told The Ross Report:
"(My uncle) was best friends with Bear Bryant, and Bear Bryant passed way," Goldberg said. "My uncle asked me if I had any interest in going to Georgia because he thought very highly of a guy named Vince Dooley. Since they were the Junkyard Dogs (and) known for defense, it sort of played into my mentality. It was red and black. It was kind of a violent style of football.
"I gave it a shot … Again, what solidified my trip was a bottle of Wild Turkey that was handed to me as I was standing on top of a bar during my recruiting trip. You know, I had a great time at Georgia, great memories. It will always be that one thing in my life that I'll want to re-enact again."
Did Goldberg just say that he signed with UGA because of a bottle of Wild Turkey? It sure sounded like it, but listen to podcast here to decide for yourself. (Personally, I don't believe it because I would've asked for at least a bottle of Crown Royal)


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Edited by Selby P., McElwain T.J.. . 416 pages. Black well Scientific Publications; , Oxford: , 1988.. $129.50.
This text is the first comprehensive work exclusively on Hodgkin disease to be published since the second edition of Henry Kaplan's monumental book in 1980. Hodgkin disease has acquired an importance to oncology out of proportion to its incidence. It was the first solid tumor that could be cured even when widely disseminated. Today, it serves as the model for multidisciplinary approaches to clinical and pathologic staging and treatment planning, as well as for the integrated use of radiotherapy and chemotherapy.
Major advances made over the past 30 years offer the expectation of cure to most patients with this previously
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The chairman of the Republican party has stepped into the debate between Sarah Palin and David Letterman.
Friday, Michael Steele suggested a boycott of Letterman's late night talk show, calling his jokes about Palin's daughter "crude, thoughtless and tacky."
Palin's family took a trip to New York recently, after which Letterman joked on his show that while there, Palin's daughter was "knocked up by Alex Rodriguez."
The joke outraged Gov. Palin and the daughter at that game-- 14-year-old Willow.
Click play for analysis from family therapist Linda Mintle, following this report.
Palin called Letterman's jokes "sexually-perverted comments" that "contributes to the atrociously high rate of sexual exploitation of minors by older men."
In an attempted apology, Letterman told his audience he was not talking about 14-year old Willow, but Palin's 18-year-old daughter Bristol.
Letterman has since said that he "probably" regrets saying the joke.
"There are thousands of jokes I regret telling on this program," he said. "Would I do anything to advocate or contribute to underage sexual abuse or misconduct? Absolutely not."
In an interview with The Today Show, Palin called on Americans to stand up to this kind of perverse humor.
She also said Letterman didn't need to apologize to her, but to all young girls.
"I would like to see him apologize to young women across the country for contributing to kind of that thread that is throughout our culture that makes it sound like it is okay to talk about young girls in that way," she said. "It's not cool. It's not funny."
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Dr. Phil is getting one special birthday present.
His TV producer son Jay McGraw and wife Erica are expecting their second child. The two are already parents to daughter Avery Elizabeth, 1.
Erica, who, along with her sisters Nicole and Jaclyn, is known as a "Dahm triplet," and Jay, 31, executive producer of The Doctors, made the announcement officially on television's Dr. Phil show.
"Robin and I are thrilled Jay and Erica are expecting again," Dr Phil tells PEOPLE, "and the due date is my birthday – Sep. 1. Avery has been getting us into tiptop babysitting shape."
At the time the couple announced their first pregnancy while on a family vacation in Italy, Dr. Phil said, "I think Jay and Erica were totally ready and will make the best parents a child could ever want. I plan to be the typical doting grandfather that gets to do all the fun stuff and none of the tough stuff."
The couple, who shared a memorable ultrasound of Avery with a national audience on Jay's show, wed in 2006 at the McGraw family home in Beverly Hills, with Dr. Phil serving as Jay's best man.
Reporting by JESSICA WEDEMEYER
Dr. Phil to Be a Grandfather – Again!
Jesse Grant/WireImage


text:
Cayin A-300B integrated amplifier Specifications
Description: Single-ended, tubed integrated amplifier with three line-level inputs and one "Preamp" input that bypasses the volume control. Tube complement (two each): 300B, 5AR4, 6SN7, 6SL7. Output power: 8Wpc into 8 ohms (9dBW). Frequency range: 15Hz–30kHz. Input impedance: 100k ohms. Input sensitivity: 280mV. Output impedances: 4, 8, 16 ohms.
Dimensions: 15" (385mm) W by 7.8" (200mm) H by 16.5" (425mm) D. Weight: 55 lbs (25kg).
Serial Number Of Unit Reviewed: 06030303.
Price: $3195. Approximate number of dealers: 42.
Manufacturer: Zhuhai Spark Electronic Equipment Co., 1195 East Jiuzhou Avenue, Zhuhai City, Guangdong Province, China. Tel: (86) 0756-382-8711. US distributor: VAS Industries, 1 Bethany Road, Building 1, Suite 16 (seriously), Hazlet, NJ 07730. Tel: (732) 888-3288. Fax: (732) 888-2988. Web: www.vasaudio.com.


text:
Chapters 24 27 29 30
According to the punctuated equilibria model..
Most new species accumulate their unique features relatively rapidly as they come into existence, then change little for the rest of their duration as a species.
When they talk about birds and yellow dumped warbler..
The two forms interbreed often in nature, and their offspring have good survival and reproduction.
Which of the following factors would not contribute to allopatric speciation?
gene flow between the two populations is extensive.
Suppose a group of male pied flycatchers migrated from a region..
the frequency of hybrid offspring would decrease.
Bacteria perform the following ecological roles. Which role typically does not involve symbiosis?
Which of the following is not evidence that charophytes are the closest algal relatives of plants?
the present of chloroplasts.
Which of the following characteristics of plants is absent in their closest relatives, the charophyte algae?
alternation of multicellular generations.
Which of the following is a land plant that has flagellated sperm and a sporophyte-dominated life cycle?
Where in an angiosperm would you find a megasporangium?
within an ovule contained within an ovary of a flower.
With respect to angiosperms, which of the following is incorrectly paired with its chromosome count?
Which of the following is not a characteristic that distinguishes gymnosperms and angiosperms from other plants?
alternation of generations.


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6 Comments
yellowbouncyball Artist from United States
Ca-razy legs! I like it +1
if the butterflies were hand-drawn i would buy this.
+1 anyways
running away from butterflies… I love it
SantoMuerto Artist
Nice flow and artwork+voted4ya
Here's mine if you got the time: http://www.designbyhumans.com/vote/detail/60165
I thought we were supposed to follow the butterflies…
Love it though :)
love it +1


text:
This week, VentureBeat compares the numbers of start-ups Zynga (which makes the super-popular Facebook games like Farmville) and Groupon (which we all know by now as the daily deals juggernaut), and the results are startling to say the least. Both are young companies headed for well-publicized IPOs — but while Groupon's is expected to be enormous, it's Zynga that's actually making a profit.
Is this one of profit's new faces? The numbers seem to say yes.
Here's the crazy part: while Zynga makes money by selling virtual (aka "nonexistent in the real world") goods to gamers, Groupon's profit model is based on taking a cut of the daily deals it offers to email subscribers — for actual products and services. One sells virtual products, the other real, but Zynga's profits were $90 million in 2010, while Groupon lost $456.3 million the same year. To compare their revenue, however, it would appear both companies are doing great – in 2010, Groupon's revenue totaled $713.4 million, while Zynga's was $598 million.
So what's really going on?
Groupon employs almost 3,000 people (globally) and Zynga has 2,268 employees (as of May). So no giant disparity there. Yet Groupon's administrative costs account for about 30% of its total operating costs, while Zynga's are only about 7%. And despite similar strategies enabling, and encouraging, users to tell one other about the companies' services, Groupon spent $208.2 million on marketing in the first quarter of this year, while Zynga spent just $40.2 million.
Both of these fairly young business models expect consumers to act as brand ambassadors. Addicted to Farmville? Facebook will let you near-constantly advertise that fact to your friends. Buying a good discount through Groupon? The site lets you share it via social networking, plus deals aren't valid, or "on," until they reach a critical mass of purchasers. Seems comparable — yet the huge discrepancy in their marketing budgets remains.
When it comes to revenue, the question isn't really about popularity — both Zynga and Groupon have huge customer bases. But these numbers demonstrate that there's a real market for goods that don't exist (or "exist," but only in Farmville or other games). The way these numbers look, when it comes to new ways for capturing consumer dollars online, it seems like Zynga, imaginary goods or no, may have more staying power than e-commerce giants that sell actual products.