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This week, the Sonoma Grapes will battle the Na Koa Ikaika Maui professional baseball team and big, beefy burgers will be sizzling.
Just head to Ichiro "Iron" Maehara Stadium in Wailuku to cheer on the home team and get your fill of some of the best and juiciest burgers on the island.
That's because Teddy's Bigger Burgers at the Lahaina Gateway is a concessionaire, and they know how to grill burgers right.
Article Photos
Teddy's Bigger Burger owner Henry Telles flips some burgers as the Na Koa Ikaika Maui mascot waves his arms in anticipation before last week's home team game in Wailuku.
The Maui News / CARLA TRACY photo
Avo-bacon burger is at the store only
The Maui News / CARLA TRACY photo
"Anytime there's a home game, we're here at the stadium," says Teddy's owner Henry Telles, who personally mans the grill himself. "We're here five to six days a week (on game days), Tuesdays to Saturdays."
Gates open at 4:45 p.m. and games begin at 5:35 p.m. Saturdays, it's often a double header. After this Sunday, the next home game will be July 10.
"The opening game was a couple of weeks ago, and we had a record crowd of 2,800 people," says Telles. "But it varies. Like today, it's 202."
Telles does brisk sales with hamburgers, cheeseburgers, crispy chicken and "even some veggie burgers I can throw on by special requests."
At the ballpark, Telles brings only five-ounce hamburger patties that are made by hand from 100-percent ground chuck. Cooked to a medium doneness, they are stacked with special sauce, lettuce, tomatoes, onions and pickles on fresh and fluffy buns. Prices start at $6 for a hamburger and go up to $9 for a cheeseburger with French fries combo platter. Other vendors sell hot dogs and such.
At Lahaina Gateway, you may sit down and dine in cool, air-conditioned comfort and order original and teri burgers in 5-, 7- and 9-ounce portions. You may double everything to indulge in two patties on one bun and you may ask the cooks to pile on toppings such as avocado, jalapenos, blue cheese, bacon and onion rings.
In addition, the Lahaina Gateway restaurant now offers grilled mahimahi sandwiches as a daily staple. Teddy's Bigger Burgers is also running with a 10 percent kamaaina discount on every menu item - all of the time - in Lahaina.
"We previously offered the discount on combos, but for a long time now locals can get 10 percent off just a burger, a shake and French fries at any time we're open," says Henry's wife and business partner, Lisa Telles, who runs the register and is chief financial officer and marketing director for their popular restaurant.
Do try the Bacado burger piled high with bacon, avocado and cheddar, and the extra-thick, made-on-Maui ice cream milk shakes.
"We're trying to be really community-oriented," says Lisa. "We're open to giving donations for fundraisers. We also try to keep it seasonal. This month's ice cream flavor is caramel cream. Maui's own Roselani ice cream is used to make the shakes."
Hours in Lahaina are from 10 a.m. to 9 p.m. on Sundays to Thursdays; and from 10 a.m. to 10 p.m. on Fridays and Saturdays.
For more details, call Teddy's at 661-9111.


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Emergency Procedures
Communication/Points of Contact
The purpose of the Emergency Response Plan is to establish policies and procedures and an organizational hierarchy for response to emergencies occurring on campus. This campus-level Emergency Response Plan guides the response of Charleston Southern University personnel and resources during an emergency. It is the official Emergency Response Plan for Charleston Southern University and supersedes previous plans and precludes employee actions not in accord with the intent of this plan, or the emergency organization created by it.
The mission of Charleston Southern University is promoting academic excellence in a Christian environment. The University is a learning and living environment comprised of faculty, staff and students, brought together for study and work in a setting designed to fulfill our mission. Part of accomplishing that mission requires a healthy and safe campus. However, crisis situations can and do occur. The mission of this plan defines and describes actions to be taken by the campus community to effectively mitigate, prepare for, respond to and recover from various crises, emergency or disasters that may affect lives, property and the institution.
The goals of this plan are:
- To protect the health and safety of the campus population
- To protect campus assets
- To preserve the University's ability to operate
- To establish clear lines of authority and coordination applicable to the crisis response
- To centralize and define the procedures to be implemented in response to a crisis event
- To ensure a timely recovery from a crisis event

subset: commoncrawl


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Investigators are seeking evidence contained in a 2003 Chevrolet Impala that McGill allegedly stole from his parents in Ontario.
McGill's parents reported their car, and their son, missing last Wednesday. The next day, the father of the Kansas girl reported that she was missing. The father told El Dorado, Kans., police that he noticed she was missing that morning.
The girl's father told police that he checked her cellular telephone records and then set up a tracking feature on his daughter's phone.
Police determined that McGill had earlier stayed in the Heritage Inn Motel in El Dorado, Kan., and had called her cell phone the morning she left.
Later in the day, the father showed police the screen on his cell phone which showed his daughter's phone to be in Missouri, east of Hannibal and north of Monroe City, court records show.
On Friday, the girl's father told police he tracked her telephone to a rural area in Michigan. An Amber Alert was issued.
That afternoon, a couple spotted the suspect's vehicle on the shoulder of Ash Road, a dirt road near M-50 in Eaton County. They had heard about the Amber Alert, and noted that the car and license plate was the same as that broadcast on the radio, court records show.
The couple saw a male and female in the car, and stayed in the area until Michigan State Police arrived.


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Shelley Vana
Steven L. Abrams
Priscilla A. Taylor
"An equal opportunity
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[Previous] | [Session 18] | [Next]
W. Smythe, M. Foote (JPL), E. Johnson, J. Daly, P. Loges, I. Puscasu (Ion Optics), S. Gorevan, P. Chu (HoneyBee Robotics), J. Granahan (SAIC)
The best clues to Mars past may be hidden below the surface of Mars. Long exposure to the sun, high winds and dust storms, large diurnal temperature excursions, and eons of space weathering combine to render a greatly modified surface, in many instances remarkable for its appearance of uniform composition. Drilling can provide access to the layers in the caps, to the permafrost and possibly, to pristine crustal material. The drilling process is complex with high demand on support resources. It is vital to make the drilling process as efficient as possible. A most promising approach is to instrument the drill string itself, thereby avoiding the complexity of sample handling, speeding and simplifying drill operations, and allowing examination of freshly exposed surfaces within the borehole.
A solid-state IR spectrometer is being integrated with a blackbody source into a package to fit within an existing Mars drill design. The borehole IR spectrometer is used to monitor facies encountered throughout the drilling process. The spectrometer/IR combination is used in reflectance spectrometer mode to monitor H2O and CO2 content, as well as iron and carbonate mineralogies.
Integration required adapting the existing spectrometer to fit within the drill -- including attaching the detectors directly to the spectrometer waveguide, developing the techniques required to seal the micro-thermopile detectors to the waveguide, implementing miniaturized digital conversion electronics, combining the spectrometer with the IR source and coupling them to a suitable window, implementing a suitable sealed package to fit within the drill, integrating and testing the package on a drill, and establishing the proper gain for both stimulus and spectrometer to permit reasonable range of Mars soil analogs. Tests have shown that both sapphire and diamond windows perform well in the drilling environment. Testing of the integrated spectrometer and drill will be completed in the coming year.
[Previous] | [Session 18] | [Next]
Bulletin of the American Astronomical Society, 37 #3
© 2004. The American Astronomical Soceity.


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Jurors in the trial of James "Whitey" Bulger Thursday saw several photos of one of the mobster's alleged victims and heard from his relatives.
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text: Get two separate memory cards. That's all you need. That way, you can save 3 of the profiles on one memory card and the other 3 on the 2nd. That way if one of your other 3 friends want to play, pop in the other one which has their profile on it. Easy fix.Originally Posted by brrtks


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After leaving Daniel at Southern and coming home, I did what I probably shouldn't have—I walked into his bedroom. There was the closet, mostly empty, except for a few hanging items that he didn't need or want at college. The desk, with stacks of graduation cards and left over thank you notes. A stuffed Winnie-the-Pooh sitting high on a shelf, wearing an academy graduation cap, surrounded by golden cords. Pooh, the well-loved, well-traveled bear, would not be going to college.
Walking down the hallway, I fought off the urge to call my son. Remembering how my mother had called me every day when I started college, I determined long ago I would never do that to my college-aged offspring.
I won't call him every day, I rationalized—I'll just call him today. And with one push of a cell phone button, we were connected.
"Hi Mom, what's up?"
"Hi Daniel, just wondering how you're doing. How's freshman orientation going? How's the food? See anyone you know?"
"Yes, Mom. They're keeping us really busy—lots of meetings. We had fun tonight—our team won the "Amazing Race" scavenger hunt.
"Wonderful. So what's the prize?"
"A free minor."
"What's that?"
"It basically extends my curfew by an hour," he replied. "Kind of like a 'Get Out of Jail Free' card."
"Great," I say with a sigh (trying to remember why 18-year-olds think it's fun to stay up late).
As the days (and now weeks) roll by, we're all getting into a comfortable routine. Life continues around work and home, and shuttling Heather, our busy seventh-grader, to school, music lessons, Pathfinders and other activities 13-year-olds enjoy. Often, my husband, Clinton, and I give Heather an extra goodnight kiss and hug, realizing that time flies by fast and one day she'll be away like her brother.
In the meantime, I know Daniel is busy with classes, homework, friends old and new, and is working hard but having a great time.
While I don't call Daniel every day now, we do keep in touch, and I especially enjoy our video Skype talks—often on a Friday or Sunday afternoon.
Sometimes I watch the live streaming of Southern's Friday evening vespers, enjoying the virtual fellowship as well as hoping to catch a glimpse of one extra-special young man in the middle of a happy sea of college students.


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Khalid bin Mahfouz
Born Dec 26, 1949
Khalid bin Mahfouz was a wealthy Saudi Arabian businessman residing in Ireland. He was accused of supporting al-Qaeda. As of 2002, he was believed to be confined in a hospital in Taif by Saudi authorities. He died on August 16, 2009 of a heart attack.… Read More
Learn about the memorable moments in the evolution of Khalid bin Mahfouz.
1949 Birth Born on December 26, 1949.
1990 40 Years Old In 1990 Khalid bin Mahfouz acquired Irish citizenship through inward-investment procedures.
2002 52 Years Old There have been numerous allegations that Khalid bin Mahfouz has been named a terrorist financier by the United Nations. The controversy springs from a report prepared by French investigator Jean-Charles Brisard and his research agency, the JCB Consulting Group, for the President of the Security Council of the United Nations in December 2002. … Read More
2006 56 Years Old 1 More Event
Bin Mahfouz was married with three children. His personal net worth was $3.2 billion in 2006, making him one of the richest people in the world; his family fortune is worth over $4 billion. … Read More
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Khalid_bin_Mahfouz.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


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Top Definition
Ashton Irwin is in a band called 5 Seconds of Summer. He is the sex god of drumming. He is Austrailian. His smile makes you stop breathing. He is the sexiest man alive and is basically living sex.
Random: Have you heard of 5 Seconds of Summer?
Fan: Yeah, their drummer Ashton Irwin is walking sex
Fan: Yeah, their drummer Ashton Irwin is walking sex
โดย 5SecondsOfMashton 31 พฤษภาคม 2013
Trending Now
Can you define these popular missing words?
Photos & Videos
Ashton Irwin is a sexy drummer from a smokin hot band called 5 Seconds Of Summer. He always wears tops which reveal his muscular dummer arms and sometimes these tops make him have a nip slip but its okay because its Ashton. He also has these oh so cute dimples which make you wanna puke. He has sexy messy curls on his head what make me wanna puncture my heart.
All in all he is a sexy piece of ass whos mating call is jigglypuff.
All in all he is a sexy piece of ass whos mating call is jigglypuff.
"Do you know Ashton Irwin?"
"Oh yeah, he plays in that band right? I want him to bang me like he bangs them drums."
"Oh yeah, he plays in that band right? I want him to bang me like he bangs them drums."
โดย Ashtons Wife 16 มิถุนายน 2013
"Ashton Irwin is physical sunshine."
โดย not a word connoisseur 22 สิงหาคม 2014
Attractive drummer for 5 Seconds of Summer
OMG Ashton Irwin is walking sex!!!!
โดย hemmingsgirl96 01 กุมภาพันธ์ 2015
Ashton Irwin is the drummer and one of 4 vocalists in the Australian band 5 Seconds of Summer. Ashton is known for his signature giggle that makes him sounds like 4 year old girl. And he is often shipped with his 3 band mates and is known for having a daddy kink.
Ashton Irwin is hot af
โดย inevitabledeath 07 มิถุนายน 2016
He is so funny kind and caring. He used to self harm but stopped because of the Fans. He drew a butterfly on a fans self harm cuts to help her stop.
Ashton Irwin is an inspirational human bean
via giphy
โดย 5sosdaisiecalm 22 สิงหาคม 2016


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The rig is a YAESU FTDX 5000D. My dream rig, after 25 years of Hamming, and well worth the wait!
I have an AMERITRON ALS-600 solid state amp.
The antenna's are a NVIS 80 meter full wave loop at 10ft, -Dipoles for 160-10 meters, and a HUSTLER vertical
with 75 radials for long haul on 10-80 meters. I added the DX ENGINEERING kit to the HUSTLER FOR 17 meters.
I recently added a 2 element MOXON home brewed beam for 17 meters,built and erected by my buddy N0KM.
The MOXON is an interesting antenna, as it is very quiet with good front to back and useable gain,it works very well!
I am a regular in the morning on 3.868 MHz, with the "Over the hill" group;--- hams from all over Colorado.
The 80 meter NVIS loop works great ! I like working DX on 17meters with the MOXON. Sorry, I DO NOT QSL!
Below are pictures of my current shack and my MOXON antenna. Also, a view of the continetal divide from my QTH.
6288388 Last modified: 2015-07-16 00:28:41, 1439 bytes
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Book Totals: 185 qso's 166 confirmed Get a free logbook at QRZ.COM


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The Falcons went a bit off the board in the third round as they selected offensive tackle Lamar Holmes of Southern Miss. Earlier, the Falcons had traded down in the draft as they gave up their #83 overall pick to the Baltimore Ravens in exchange for the #91 and #164 picks.
He's a big boy
Clearly the Falcons are addressing their biggest need from last year, protecting Matt Ryan. The question is how well and how quickly Holmes and Konz will fit in with the offensive line. I don't know much about Holmes at this point so here are some scouting report notes:
Pro Football Weekly: Worked hard to shed weight as a senior, dropping 30 pounds and showed fairly well at the East-West Shrine Game, but has limited value as a right tackle only in the pros.
National Football Post: A big, tall well-proportioned offensive tackle with good girth through the base and a naturally thick frame. Showcases the ability to bend, stay balanced toward the edge and sit into his stance. Isn't real rangy, but understands angles and puts himself in good position to sustain the block. However, has a tendency to stop moving his feet when trying to punch and engage into contact, and routinely can be slipped on the edge. Possesses natural anchor strength, sits down into his base when trying to anchor and works his hands well to gain leverage.
Here's some feedback from the Twitter machine….
The Falcons take Lamar Holmes from Southern Miss. Huge guy that is great in pass protection. Another solid pick.
— Brian L Jones (@Brian_L_Jones) April 28, 2012
I don't love Bobbie Massie, but he isn't "clear" over Lamar Holmes as an OT. Falcons in solid force at Shrine Game, Holmes impressed there.
— Eric Galko (@OptimumScouting) April 28, 2012
The Falcons' scouting department does their home work. Lamar Holmes is a very good OL. Good stretch at USM
— Steve Robertson (@ScoutSteveR) April 28, 2012
And here is a youtube draft profile for your viewing pleasure….


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You think Paula Deen has it bad? Chris Brown knows it could be worse. The singer endured criminal charges for his role in a 2009 altercation with then-girlfriend Rihanna. Wrigley canceled Brown's endorsement deal soon after.
Deen has also suffered an exodus of sponsors in the wake of revelations that she'd used a racial slur in years past. Home Depot and Target, to name two. I'd love to tell you that Deen and Brown are exceptions to the rule. Unfortunately, that's not true.
Corporate America spends $50 billion on endorsement deals annually in hopes of converting shoppers into buyers. As the following slideshow demonstrates, they're usually quick to go elsewhere when a spokesperson's reputation takes a turn for the worse.
Usually, but not always. Nike's (NYSE: NKE ) long-term commitment to Tiger Woods has paid off nicely while two other stocks have used various spokespeople to gain worldwide appeal. Care to learn more? Our analysts have just released a special report detailing everything you need to know about investing in the biggest U.S. brands. Click here to claim your free copy now.


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Flat, open flowers may be accessible to just about any kind of visitor, but those with more complex shapes have co-evolved with their pollinators, and don't welcome others. This is the case of kudzu, that formidable Asiatic invader. In North America, it propagates mostly through runners and rhizomes because native pollinators can't handle its flowers, so seeds are seldom produced. In recent years, a large black bee from Asia, the giant resin bee (Megachile sculpturalis), arrived in North America by accident and started spreading across the landscape. Guess what: This bee is a very efficient pollinator of kudzu's flowers. So, now this invasive can also propagate by seed. Oh, joy!
|Scooped by David Rowing


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Genes crucial for cancer development can be mutated via various mechanisms, which may reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding for effectors along the MAPK pathway are central for transformation. BRAF point mutation is most common in sporadic tumors. By contrast, radiation-induced tumors are associated with paracentric inversions activating the receptor tyrosine kinases RET and NTRK1. We report here a rearrangement of BRAF via paracentric inversion of chromosome 7q resulting in an in-frame fusion between exons 1–8 of the AKAP9 gene and exons 9–18 of BRAF. The fusion protein contains the protein kinase domain and lacks the autoinhibitory N-terminal portion of BRAF. It has elevated kinase activity and transforms NIH3T3 cells, which provides evidence, for the first time to our knowledge, of in vivo activation of an intracellular effector along the MAPK pathway by recombination. The AKAP9-BRAF fusion was preferentially found in radiation-induced papillary carcinomas developing after a short latency, whereas BRAF point mutations were absent in this group. These data indicate that in thyroid cancer, radiation activates components of the MAPK pathway primarily through chromosomal paracentric inversions, whereas in sporadic forms of the disease, effectors along the same pathway are activated predominantly by point mutations.
Thyroid papillary carcinoma is the most common type of endocrine malignancy. In this tumor, mutations of genes coding for effectors along the MAPK pathway are central for transformation. Indeed, activating mutations of BRAF, RET, or RAS are found in 70% of all cases and rarely overlap in the same tumor (1–3).
The RET gene codes for a cell membrane receptor tyrosine kinase (4, 5). In papillary carcinomas, it is activated via chromosomal rearrangement, which results in fusion of the 3′ portion of the gene coding for the tyrosine kinase domain to the 5′ portion of various genes, creating chimeric oncogenes named RET/PTC (6, 7). The 2 most common rearrangement types, RET/PTC1 and RET/PTC3, are paracentric inversions, since both RET and its respective fusion partner, H4 or NCOA4 (ELE1), reside on the long arm of chromosome 10 (8, 9). The fusion leads to ligand-independent activation of the truncated RET receptor. Binding of activated RET to SHC via Y1062 has been shown to be critical to RET-mediated transformation and dedifferentiation, primarily through the RAS-RAF-MAPK pathway (10, 11). RAS, in turn, can be independently activated by point mutations, primarily in the follicular variant of papillary thyroid cancer (12).
Most recently, point mutations activating the BRAF serine/threonine kinase have surfaced as the most common genetic event in sporadic thyroid papillary carcinomas (1, 13). RAF proteins, including ARAF, BRAF, and CRAF or RAF-1, phosphorylate MAPK/ERK kinase (MEK) within the MAPK cascade upon stimulation by RAS. BRAF somatic mutations were first discovered in malignant melanomas and in a smaller subset of colorectal and ovarian cancers (14). The majority of mutations in those tumors and virtually all mutations in thyroid carcinomas result in a valine-to-glutamate substitution at residue 600 (V600E), formerly designated as V599E. This mutation is believed to produce a constitutively active kinase by disrupting hydrophobic interactions between residues in the activation loop and residues in the ATP binding site that maintain the inactive conformation, allowing development of new interactions that fold the kinase into a catalytically competent structure (15). Correspondingly, BRAFV600E exhibits elevated basal kinase activity and transforms NIH3T3 cells with high efficiency (14).
Conceivably, other alterations that would release the inhibitory constrains of the catalytic domain of BRAF could also result in kinase activation. Indeed, loss of the N-terminal regulatory domains as a result of fusion to different genes during in vitro transfection has been shown to activate BRAF kinase and transform NIH3T3 cells (16, 17). Despite those reports, which appeared more than a decade ago, this mechanism of BRAF activation has not been identified in human tumors. Here, we report the activation of BRAF by chromosomal rearrangement that results in its N-terminal truncation in several papillary thyroid carcinomas. We show that the fusion gene exhibits elevated basal kinase activity, stimulates ERK phosphorylation, and induces transformation of NIH3T3 cells, which is consistent with its functioning as an oncogene. This observation also provides insights into distinct mechanisms of activation of components of the MAPK pathway in radiation-induced cancers, which involve chromosomal inversions, in contrast to sporadic cancers, where it happens predominantly by point mutations.
The possibility of BRAF involvement in chromosomal rearrangement was studied by fluorescence in situ hybridization (FISH). A contig of 3 P1 artificial chromosome (PAC) clones of approximately 330 kb, spanning the entire BRAF gene, was assembled to use as a probe (Figure (Figure1A).1A). Benign thyroid cells showed, as expected, 2 signals. Analysis of 32 papillary thyroid carcinomas revealed 1 tumor containing 3 signals, whereas subsequent hybridization with a chromosome 7 centromeric probe demonstrated the presence of 2 copies of the chromosome (Figure (Figure1B).1B). Since the split of one BRAF signal resulted in a pair of signals located at a relatively constant distance from each other, the likely mechanism for this event was intrachromosomal inversion.
The identification of the fusion partner was achieved by 5′ rapid amplification of cDNA ends (RACE) using tumor poly(A)+ RNA and a pool of primers designed along the 3′ end of the BRAF gene. RACE products were sequenced, and several of them revealed a fusion between exon 9 of BRAF and exon 8 of the A-kinase anchor protein 9 (AKAP9) gene (Figure (Figure2A).2A). Confirmation of the fusion was obtained by RT-PCR with primers located in exon 8 of AKAP9 and exon 10 of BRAF, which yielded the expected product of 181 bp. Genomic DNA was used for PCR to identify the fusion at the genomic level, which was found to reside between nucleotide 364 of AKAP9 intron 8 and nucleotide 4,930 of BRAF intron 8. The reciprocal fusion gene product was subsequently identified by RT-PCR using tumor cDNA, indicating the reciprocal nature of the rearrangement. Further confirmation was obtained by double-color FISH with probes corresponding to the BRAF and AKAP9 genes (Figure (Figure2B).2B). Since the BRAF gene is located on chromosome 7q34 (18) and AKAP9 on 7q21–q22 (19–21), the AKAP9-BRAF fusion results from inv(7)(q21–22q34) (Figure (Figure2C).2C). Using primers located within the 5′ and 3′ untranslated region of AKAP9 and BRAF, respectively, the AKAP9-BRAF coding cDNA sequence was amplified from the tumor, cloned into the pCR-XL-TOPO vector, and sequenced (GenBank accession number AY803272). Analysis of the sequence (4,567 bp total size) revealed a 4,476-bp open reading frame (ORF) containing exons 1–8 of AKAP9 fused in-frame with exons 9–18 of BRAF (Figure (Figure2D).2D). Based on the known sequences of the untranslated regions of both genes, the predicted length of the complete AKAP9-BRAF cDNA is 4,849 bp. Four transcript variants of human AKAP9 have been previously identified based on several coding region differences. The AKAP9 sequence of the chimeric cDNA lacked 36 nucleotides at position 269–304 of transcript version 1 (GenBank accession number NM_147171), which indicates that it corresponded to either transcript version 2 or 3 of the gene. Multiple RT-PCR reactions revealed no splice variants of the fusion transcript in the tumor cDNA. Western blot analysis of the tumor using an antibody to the C-terminus of BRAF showed a band of approximately 170 kDa, corresponding to the predicted molecular weight of 172 kDa for the fusion protein (Figure (Figure2E).2E). The same band was detected with an antibody against the N-terminus of AKAP9.
The wild-type AKAP9 gene encodes a 453-kDa protein capable of binding the type II regulatory subunit (RII) of protein kinase A (PKA) as well as other signaling proteins, anchoring them to the centrosome and Golgi apparatus (19–21). Several isoforms arising through alternative splicing are selectively expressed in most human tissues at low abundance (19, 20). The AKAP9 protein localizes by immunofluorescence as a single perinuclear dot and some surrounding dispersed fluorescence, corresponding to the centrosome and Golgi compartments, respectively, in interphase HeLa and SaOS2 osteosarcoma cells (19, 20). Based on the sequence of the chimeric cDNA, the fusion protein is predicted to lack 2 putative RII binding regions and the centrosome localization domain of AKAP9 (20, 22, 23).
In papillary thyroid carcinomas negative for the fusion and in non-neoplastic thyroid tissue, AKAP9 expression was readily detectable by RT-PCR (data not shown), and the protein was seen as a single perinuclear dot with faint diffuse cytoplasmic staining (Figure (Figure3A).3A). In the tumor expressing the AKAP9-BRAF protein, the perinuclear dot was no longer identifiable, whereas diffuse staining was observed in the cytoplasm (Figure (Figure3B).3B). However, the presence of intact centrosomes in the tumor cells was confirmed by immunohistochemistry with an antibody against the centrosomal protein γ–tubulin (data not shown). This is consistent with the absence of the centrosomal localization domain of AKAP9 in the fusion protein, which prevents its preferential targeting to the centrosomal compartment.
The wild-type human BRAF gene codes for an 84-kDa serine/threonine kinase in the MAPK pathway (16, 24). Structurally, BRAF, similar to other RAF kinases, contains 2 highly conserved N-terminal regulatory domains, CR1 and CR2, that mediate autoinhibition of BRAF and a C-terminal protein kinase domain (CR3). CR1 includes the RAS-GTP binding domain (RBD), which mediates RAS binding, triggering the recruitment of the protein to the cell membrane and kinase activation (25). Based on the cDNA sequence, the AKAP9-BRAF fusion protein is predicted to lack the BRAF N-terminal regulatory domains, including RBD, and to retain an intact kinase domain. Loss of the regulatory domains would be expected to lead to constitutive activation of BRAF kinase in a RAS-independent manner.
We characterized the kinase activity of the AKAP9-BRAF fusion protein by transient transfection of myc epitope–tagged versions of cDNAs for AKAP9-BRAF, BRAFV600E, or wild-type BRAF into COS7 cells, using bacterially purified MEK1 as a substrate for phosphorylation (Figure (Figure4A).4A). Basal BRAF kinase activity of the fusion protein was 6-fold greater than BRAFWT activity and not further increased by coexpression of activated RAS. Basal activity of BRAFV600E was also increased, but to a lesser extent, and was modestly increased by H-RASG12V. By contrast, H-RASG12V increased BRAFWT kinase activity by about 2.5-fold. The fusion protein stimulated endogenous ERK1/2 phosphorylation to a similar extent as BRAFV600E in pooled stably transfected NIH3T3 cells, whereas overexpression of BRAFWT had no discernible effect (Figure (Figure44B).
The ability of AKAP9-BRAF fusion protein to induce transformation was studied in an NIH3T3 cell focus assay (Figure (Figure4C).4C). Vector and BRAFWT transformed cells at very low efficiency. AKAP9-BRAF showed the highest transformation activity in this assay, followed by H-RASG12V and BRAFV600E. In addition, NIH3T3 cells stably transfected with empty vector, BRAFWT, AKAP9-BRAF, BRAFV600E, and H-RASG12V were assayed for tumorigenicity in nude mice. Two weeks after injection of 106 cells, tumors of at least 5 mm in diameter were formed with complete penetrance (6 out of 6 animals, repeated in 2 independent experiments) for AKAP9-BRAF, BRAFV600E, and H-RASG12V constructs, whereas vector and BRAFWT did not lead to the development of tumors (0 our of 6 animals). These results demonstrate that AKAP9-BRAF fusion leads to activation of BRAF kinase and transformation of NIH3T3 cells.
To determine the prevalence of AKAP9-BRAF fusion in various populations, we used RT-PCR with primers flanking the fusion point to study a large series of papillary thyroid carcinomas (Table (Table1).1). In a group of 102 sporadic papillary tumors, no additional case of the fusion was found. We also examined papillary carcinomas from 2 cohorts of Belarussian children and adolescents exposed to radiation after the Chernobyl nuclear accident in 1986. Among 28 tumors that developed 5–6 years after exposure, 3 (11%) were positive for the fusion, whereas 64 tumors developing 9–12 years after the accident were all negative (Figure (Figure5A).5A). Paraffin blocks were available for immunohistochemical analysis with AKAP9 antibody in 2 out of 3 positive cases. Both cases showed a shift in subcellular localization of AKAP9 from the centrosomal pattern seen in adjacent non-neoplastic thyroid tissue to diffuse cytoplasmic distribution in tumor cells (Figure (Figure55B).
We also tested these tumors for BRAF point mutation leading to the V600E substitution. The mutation was identified in 38 (37%) sporadic tumors, in 10 (16%) tumors developing 9–12 years after exposure, but in none of the tumors that developed 5–6 years after exposure (Figure (Figure6).6). The differences in prevalence of the 2 types of BRAF activation were statistically significant between the early radiation group and both late radiation and sporadic groups (Table (Table11).
The MAPK signaling pathway is a ubiquitously present regulator of cell growth, proliferation, apoptosis, and differentiation. Recently, BRAF, an essential component of the kinase cascade, has received renewed attention since mutations in the gene were identified in several types of human cancer. Indeed, activating point mutations of BRAF have been found in more than 60% of malignant melanomas, 10–14% of colorectal and ovarian cancer, and in very few cases of lung cancer, soft tissue sarcomas, and other cancer cell lines (14, 26, 27). Thyroid cancer was promptly added to the list with 36–69% prevalence of BRAF mutation (1, 2, 13, 28). However, neither BRAF nor other intracellular effectors along the MAPK pathway have been previously implicated in human carcinogenesis through mechanisms other than point mutation. In the present study, we demonstrate BRAF activation by chromosomal rearrangement that results in BRAF fusion to the AKAP9 gene in thyroid papillary carcinomas. The fusion protein lacks the regulatory domains of BRAF, which results in constitutive kinase activation in a RAS-independent manner, and exhibits transforming activity similar to that of the most common BRAFV600E.
The fusion partner of BRAF, the AKAP9 gene, belongs to the group of A-kinase anchor proteins that have the common function of binding to the regulatory subunit of PKA and targeting it to discrete locations within the cell (29). AKAP9, in particular, has predominantly centrosomal and Golgi compartmentalization (19–21). The fusion protein lacks the C-terminal centrosomal domain and, as expected, loses its centrosomal localization in cancer cells. Moreover, immunohistochemical analysis with AKAP9 antibody revealed no evidence of wild-type AKAP9 within centrosomes of cancer cells in all cases positive for the fusion by RT-PCR. This may suggest the competitive inhibition of wild-type AKAP9 by AKAP9-BRAF, although further studies are required to confirm this. AKAP9 is an important regulator of c-AMP–dependent PKA and interacts with many other signaling proteins, including serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2A, and PKC-ε (20, 30). Thus, deregulation of its function in cells harboring AKAP9-BRAF fusion may affect a variety of physiological functions. On the other hand, neither AKAP9 nor other AKAP genes have been implicated in carcinogenesis so far. Therefore, it remains unclear whether or not the AKAP9 portion of the fusion gene contributes independently to its transforming potential, besides providing an active promoter driving the expression of truncated BRAF.
Over the last decade, it has become apparent that activation of components of the MAPK pathway in thyroid cancer can be achieved through several distinct genetic events, i.e., RET/PTC (or, less frequently, TRK) rearrangements, RAS point mutations, or BRAF point mutations. However, the relative frequency of each event varies significantly in different populations. BRAF point mutation is the most common change in sporadic adult papillary carcinomas. In contrast, tumors associated with accidental or therapeutic irradiation have exceedingly high frequency of RET/PTC rearrangements and absence or low prevalence of BRAF point mutations (31–38). The 2 most common RET/PTC types found in up to 80% of radiation-associated tumors, RET/PTC1 and RET/PTC3, are both paracentric inversions of chromosome 10q (39, 40). Another rearrangement, which contributes to about 7% of radiation-induced papillary carcinomas, involves the nerve growth factor gene NTRK1 and results from paracentric inversion of chromosome 1q (41, 42). Here, we report the identification of another paracentric inversion, involving 7q, which is also more common in radiation-associated tumors, especially those appearing with a short latency. These tumors, however, revealed no BRAF point mutations. The sharp contrast in mechanisms of activation of the same gene in radiation-induced and sporadic tumors points to the association between environmental factors and distinct genetic mechanisms of activation of MAPK pathway components: through chromosomal rearrangement in patients exposed to radiation or through point mutations in patients with no radiation history (Figure (Figure77).
The vast majority of RET/PTC and all TRK and AKAP9-BRAF chromosomal rearrangements in radiation-induced tumors are paracentric inversions. In epithelial cancers as a whole, point mutations are more prevalent than chromosomal rearrangements, and the latter are usually translocations or interchromosomal exchanges. The reason for the striking predisposition of radiation-induced thyroid cancers to paracentric inversions is not entirely clear, although some evidence suggests that this may be related to the organization of chromosomal domains and arm domains and spatial interaction between pairs of various chromosomal regions. Indeed, there is a general consensus that free DNA ends produced in the nuclear volume after passage of radiation tracks have to be within a certain distance of each other in order to recombine (43, 44). Residing within the same chromosomal arm domain would limit their maximum separation and help to fulfill this requirement. Indeed, the yields of intra-arm chromosomal exchanges after both low– and high–linear energy transfer radiation has been shown to exceed the expected levels, calculated based on spatial randomness, by up to 10-fold (45). The conditions would be even more favorable if potentially recombinogenic foci within the arm domain were frequently juxtaposed to each other, as was demonstrated in human thyroid cells for RET and H4, the RET/PTC1 partners (46).
In this study, we observed significant difference in mechanisms of BRAF activation not only between early radiation–associated tumors and sporadic cancers, but also between early and late post-radiation tumors. Such a difference is not without precedent. Similar variation has been previously observed with respect to RET/PTC rearrangements between post-Chernobyl tumors developing 10 years or less after exposure and those manifesting after a longer latency (34, 35). Indeed, the overall prevalence of RET/PTC was significantly higher in the former group, and RET/PTC3 was the most common type. By contrast, tumors arising after a longer latency had lower prevalence of RET/PTC, and the predominant type was RET/PTC1, both of which are features more typical of sporadic tumors. The present study demonstrates that late post-radiation tumors also occupy an intermediate position with respect to the predominant mechanism of BRAF activation. This suggests that tumors arising early after exposure are likely to be initiated through direct radiation damage–related genetic events, such as chromosomal rearrangements occurring after double-stranded DNA breaks. As for the tumors developing after a longer latency, their pathogenesis may involve a combination of radiation-related and -unrelated mechanisms and rely on molecular alterations which develop after repair of radiation-induced DNA damage that are stimulated by genomic instability that persists in the progeny of the exposed cells (47, 48).
In summary, we report here a novel mechanism of in vivo BRAF activation via inversion of chromosome 7q, resulting in BRAF fusion to the AKAP9 gene. AKAP9-BRAF functions as an oncogene and is more prevalent in thyroid carcinomas with recent history of radiation exposure. The significance of this study is 2-fold. It demonstrates a novel mechanism of BRAF activation in human tumors, showing for the first time that intracellular effectors along the MAPK pathway can be activated by recombination. In addition, it shows correlation between the nature of the mutagen and the mechanism of mutation and suggests that paracentric chromosomal inversions represent a common genetic mechanism of radiation-associated thyroid carcinogenesis.
Frozen tissues from sporadic thyroid carcinomas were obtained from the Department of Pathology, University of Cincinnati, following an institutionally approved tissue procurement protocol and through the Cooperative Human Tissue Network. Post-Chernobyl tumors from Belarussian patients who underwent surgery in 1991–92 were available as archival paraffin-embedded tissue. Samples from Belarussian patients who underwent surgery in 1995–1998 were from the Experimental Division of the Institute of Pathology, University of Munich, and available as RNA extracted from frozen tissue; they were negative for RET/PTC and TRK rearrangements (35). The study was approved by the University of Cincinnati Institutional Review Board.
Tumor touch preparations were made from snap-frozen tissues. PAC clones for BRAF (RP4-726N20, RP5-839B19, RP4-813F11) were obtained from BAC/PAC Resources, Children's Hospital Oakland, and bacterial artificial chromosome (BAC) clones for AKAP9 (CTB-104F4, CTB-161K23) from Open Biosystems. The probes were labeled by nick translation using SpectrumOrange-dUTP and SpectrumGreen-dUTP (Vysis Inc.), respectively. An α-satellite DNA centromeric probe for chromosome 7 was obtained from Vysis Inc. Nuclei were counterstained with DAPI. Microscopy was performed with a Leica Microsystems TCS 4D confocal laser scanning fluorescence microscope with digital image capture. One hundred nuclei were scored for each preparation.
Fifty micrograms of poly(A)+ RNA from the index case were used for 5′ RACE using the 5′ RACE System for Rapid Amplification of cDNA Ends (Invitrogen Corp.). The BRAF gene–specific primers were designed for cDNA synthesis (5′-GATGACTTCTGGTGCCATCC-3′, 5′-AACTGCTGAGGTGTAGGTGCTGTC-3′, and 5′-GTCTCGTTGCCCAAATTGAT-3′) and for subsequent PCR reactions (5′-TTTCACTGCCACATCACCAT-3′ for first PCR and 5′-TCACTCGAGTCCCGTCTACC-3′ for nested PCR). The 5′ RACE products were excised from the gel, purified, and sequenced using an automated ABI 377 sequencer (PerkinElmer).
Total RNA was used to amplify the ORF of the chimeric cDNA using primers located in the 5′-untranslated region of AKAP9 (5′-ACCACCCCTCAACCCCTGTTTT-3′) and 3′-untranslated region of BRAF (5′-TTCCTTTTGTTGCTACTCTCCTGA-3′). The PCR product was electrophoresed in an agarose gel, purified from the gel, and cloned into the pCR-XL-TOPO vector (Invitrogen Corp.). Several clones were fully sequenced. The genomic AKAP9-BRAF fusion was amplified with primers 5′-GCAACTCAACCAAGTGAAAATG-3′ and 5′-GGTTGATCCTCCATCACCAC-3′, yielding a product of approximately 2.4 kb, and the reciprocal fusion product cDNA was amplified with primers 5′-ACCCGCCTCGGACTCTATT-3′ and 5′-GTTGGGCTTCCATCTGTAGC-3′, yielding a product of 242 bp.
Frozen tissues from papillary carcinomas were used for Western blotting, which was performed as previously described (49). We loaded 50 μg of protein on a 5% polyacrylamide gel. After transfer, the membranes were incubated with anti–C-terminus BRAF polyclonal (Raf-B, C-19; Santa Cruz Biotechnology Inc.) or anti–N-terminus AKAP9 monoclonal (AKAP450; BD Biosciences) antibodies. The same AKAP9 antibody in 1:50 dilution was used for immunohistochemical analysis, which was performed on paraffin sections after overnight pretreatment in borate buffer using avidin-streptavidin immunoperoxidase detection. Rabbit anti–γ-tubulin polyclonal antibody was provided by K. Fukasawa (University of Cincinnati College of Medicine, Cincinnati, Ohio, USA) (50) and was used in 1:800 dilution on paraffin sections after pretreatment in borate buffer.
COS7 cells were transiently cotransfected with either pEFP vector or pEFP-containing myc-tagged BRAFWT, AKAP9-BRAF, or BRAFV600E and either pBabe puro or pBabe puro–HRASG12V using Lipofectamine 2000 (Invitrogen Corp.). After 48 hours, cell extracts were prepared, immunoprecipitated with mouse anti–myc-IgG (Upstate Cell Signaling Solutions), and kinase activity determined as directed by the manufacturer using bacterially purified MEK1 as substrate, and Western blotting with pMEK1 antibody as a read-out (B-RAF Kinase Assay Kit; Upstate Cell Signaling Solutions). To determine the effects of the BRAF mutants on endogenous ERK1/2 phosphorylation, we incubated pools of stably transfected cells for 12 hours without serum prior to lysate preparation. Lysates were centrifuged, the supernatant collected, and 100 μg of extract subjected to SDS-PAGE. Proteins were transferred to a nitrocellulose membrane and subject to Western blot analysis with anti–phospho-ERK1/2, anti–total ERK1/2, or anti-BRAF (Santa Cruz Biotechnology Inc.) antibodies.
For focus assays, NIH3T3 cells were transfected with empty vector or the indicated BRAF and H-RAS expression plasmids using lipofectamine. After 2 days, cells were split into six 100-mm3 dishes and incubated with DMEM containing 5% calf serum for 21 days. Cells were stained with 0.4% crystal violet and foci counted. For the mouse xenograft experiments, NIH3T3 cells were cotransfected with pBabe puro and pEFP vector, pEFP–myc BRAFWT, pEFP–AKAP9-BRAF, pEFP–myc BRAFV600E, or pBabe puro–H-RASG12V and mass selected by incubation with DMEM containing 5% calf serum and 1 μg/ml puromycin for 3 weeks. A total of 106 pooled cells was injected into nude mice. Animals were killed after 2 weeks, and nodules larger than 5 mm in diameter were scored as positive.
For the detection of AKAP9-BRAF fusion, cDNA amplification was achieved by PCR using primers located in exon 8 of AKAP9 (Ex8A, 5′-AGCAAGAACAGTTGATTTTGGA-3′) and exon 10 of BRAF (Ex10B, 5′-GCAGACAAACCTGTGGTTGA-3′), with the expected product of 181 bp. The PCR products were electrophoresed on agarose gels and bands visualized by staining with ethidium bromide (frozen tissues) or by transfer to a nylon filter and hybridization with an internal oligonucleotide probe (PR, 5′-AAACTTCAGAAAGAACTCAATGTACTT-3′) labeled with 50 μCi of [γ-32P]-ATP (paraffin-embedded tissue). Detection of V600E BRAF mutation was performed from DNA using real-time PCR and fluorescence melting curve analysis, as previously reported (51), or from cDNA using real-time RT-PCR with primers 5′-CGACAGACTGCACAGG-3′ and 5′-TGACTTCTGGTGCCAT-3′ and the same probes.
The comparison between groups was performed using a 2-tailed Fisher exact test. Differences were considered significant when P was less than 0.05.
This study was supported by NIH grant R01 CA88041 and American Cancer Society grant RSG-03-027-01-CCE (to Y.E. Nikiforov), NIH grant R01 CA50706 (to J.A. Fagin), a grant from the American Cancer Society Ohio Chapter #06001011 (to J.A. Knauf), and a grant from Deutsche Krebshilfe, Bonn, Germany (to H.M. Rabes). Collection of tissue samples was supported in part by a grant from the NIH (PHS M01 RR08084) and through the Cooperative Human Tissue Network funded by the National Cancer Institute. We thank Kenji Fukasawa for γ-tubulin antibody, Mickey Croyle for technical assistance, and Richard Marais for the BRAFWT and BRAFV600E expression vectors.
See the related Commentary beginning on page 20.
Nonstandard abbreviations used: BAC, bacterial artificial chromosome; FISH, fluorescence in situ hybridization; MEK, MAPK/ERK kinase; ORF, open reading frame; PAC, P1 artificial chromosome; PKA, protein kinase A; RACE, rapid amplification of cDNA ends; RBD, RAS-GTP binding domain; RII, type II regulatory subunit.Conflict of interest: The authors have declared that no conflict of interest exists.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Can you take your Wii to a friends house that has wi-fi?
There's really no other way.
hey guys, i have a serious problem, i got a wii n i dnt have the internet, is there any way i can get downloadable games (ie. zelda etc.) on my wii without having the internet? Cracked SD card maybe? plz help!
Can you take your Wii to a friends house that has wi-fi?
There's really no other way.
Yeah, true.. But then you would always have your Wii at your friends house.
I think you should just get a wireless router, or you could get those awesome
Nintendo Wi-Fi USB Connectors. I have one, and it works perfectly. (:
Other than that, I don't think you could get any downloadable games w/o
the internet.
♥_December 19th, o8`_♥
My amazing Games
CounterStrike || Left 4 Dead || World of Warcraft: Lich King.
Steam ID: APPLExCHiCk
Wanna play CounterStrike/Left4Dead? Hit me up (:
WoW - Realm/Vashj || Character/Zaduka || Horde, ftw!
Status - O_o Just got back guys. Nice to see you all again!


text:
I saw there were a couple requests for AMAs with me, so thought Valentines Day would be appropriate. For those who didn't' request, I am a formerly forever-alone Rolling Stone (and former New York Times) journalist who went undercover in the seduction community, and somehow ended up as the international spokesperson for pickup artists after writing The Game. I also have written a lot of books with rock stars, porn stars, and other characters, and interviewed thousands of musicians, most recently Suge Knight, Mick Jagger, and Skrillex. AMA about A.
Proof that this is me is posted on: www.facebook.com/neilstrauss and www.neilstrauss.com
I assume there are going to be a lot of questions, especially about pickup, so I've asked a couple friends to help answer a few so I can keep up. Their usernames are: earcaraxe, rico81, and aaronfrankel.
UPDATE (2/15/12, 9:30 a.m.): This ended at 2 p.m. yesterday. For all the questions that came in afterward that I didn't get to answer, I will do another AMA in the future, so please repost them. If your question was NOT answered below and is URGENT, feel free to email me through the website (url above), identify yourself as a Redditor, and I will get you your answer. Otherwise, thanks for an incredible array of questions, comments, opinions, insights, honesty, and humor. Talk again soon....


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What is the purpose behind the ADEA?
Solutions for Chapter 13.3
What is the purpose behind the ADEA?
We are given information from the case Morelli v. Cedel 141 F. 3d 39 (2nd Cir. 1998) for consideration and asked to answer the following question:
We are asked to state the rationale behind the Age Discrimination and Employment Act of 1967 (ADEA).
Under the ADEA, discrimination against a person based on age became illegal. The ADEA was designed to protect to ability of a person of any age to obtain employment, services and access to public facilities.


text:
Upcoming Board Meetings:
September 28 at 8am – Community Room at KCPT
October 11 at 4pm (Annual Board Meeting) – Three Points
November 29 at 8am – Community Room at KCPT
Upcoming Committee/Task Force Meetings:
Futures Committee Meeting, October 21, 2016 at 8:00am – The Reed Room at KCPT
Facilities Due Diligence Task Force Meeting, October 25, 2016 at 8:30am – The Lehrer Room at KCPT
All KCPT board and committee meetings are open to the public.
Contact Judith Ferguson for meeting details at 816-398-4269.
Chairman: Becky Tilden
Vice Chair, Futures: Ethan Whitehill
Vice Chair, Operations: Thomas Dowling
Treasurer: William Coughlin
Secretary : Stuart Shaw
Dr. Charles Ambrose
Julie Amor
Kirsten Byrd
David Chavez
Jamie Cummings
Raymond L. Daniels, Ed.D.
Mark Eagleton
Mike Gross
Doranne Hudson
Kiran Huggins
Scott Hughes
Nancy Lee Kemper
John Learned
Willetta Willis-McGhee
Juergen Massey
Doug Michelman
Mark Opara
Charles Romero
Bradley Scott
Mark Thompson
Erin Turley
Christopher Underwood
Kimberly Wilkerson
Daryl Williams
Erik Wullschleger


text:
The role of chronic pyelonephritis in the causality of contracted kidney and uremia and its association with hypertension became widely appreciated with the appearance of the papers of Longcope1 and Weiss and Parker2 20 years ago. It has been assumed usually that the hypertension was secondary to the pyelonephritis rather than that the reverse relationship might be true. However, common as pyelonephritis is, hypertensive vascular disease is even commoner. The postulate that the hypertensive kidney might be more susceptible to pyelonephritis finds support in a number of experimental observations,3-5 but most strongly in that of De Navasquez6 who demonstrated that scarred kidneys were much more apt to become infected when exposed to a challenging bacteremia. As one of many possible approaches to the problem of comparing susceptibilities of hypertensive and nonhypertensive persons to pyelonephritis, a group of hypertensives was compared with a group of carefully matched controls for incidence of
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Andy Reid roamed the Eagles sideline just after the national anthem and it was hard not to look at the coach and think: "This might be the last time Cap'n Andy steers this ship."
If the Eagles had delivered another dud and the ship had sunk to 3-8, calling to mind Jeffrey Lurie's preseason declaration that another 8-8 record would not be enough, there was the smidgen of a chance that Reid would not open Monday's day-after news conference with "Injuries . . . "


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Editor's note: The Sentinel offers nonprofit and other community organizations an opportunity to promote upcoming events for free in this community calendar for three days before the event. Events needing reservations also may be promoted for up to two weeks prior to the reservation date.
Submit items at least one business week before publication via email, firstname.lastname@example.com; voice mail, 248-6741 or (800) 827-6397 (voice mail ext. 118); online, Virtual Newsroom at www.lewistownsentinel.com; or mail or drop off, The Sentinel, P.O. Box 588 Lewistown, PA 17044.
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Reserve now
Zumbathon - 1-3 p.m., April 26, TAZ Fitness, Burnham. Benefits Big Brothers Big Sisters of Juniata Valley. Tickets are $15 in advance and $20 at the door and can be purchased at Big Brothers Big Sisters 107 E. Main St., Lewistown, 248-4034, or firstname.lastname@example.com or at TAZ Fitness.
Congestive heart failure support group - 6-7 p.m., April 29, surgical center lobby, Geisinger-Lewistown Hospital. Register by contacting Julie Maidens at 242-7486 or firstname.lastname@example.com, by April 21.
Bus trip - Sept. 21-25, Wildwood, N.J. Includes lodging, four breakfasts, three dinners, trip to Atlantic City, Cape May and Smithville, dolphin-watching cruise and daily activities. Cost: $365. Organized by members of St. Stephen's Lutheran Church. For more information or to reserve call 436-2327 by April 29.
Free chili, corn bread and salad luncheon - Noon, April 30, First United Methodist Church Lewistown. For transportation call 258-1011 by noon Tuesday, April 29.
Lunch & Learn Series - Noon-1 p.m., April 30, PA CareerLink Mifflin County, Lewistown. Learn about cloud technology and how it can impact work. $10 fee includes lunch. Make checks payable to TIU 11. RSVP to Cher Harpster, 6395 state Route 103 North, Building 58, Lewistown, PA 17044.
Salad bar - 11 a.m.-1:30 p.m., May 2, St. Mark's Episcopal Church, 21 S. Main St., Lewistown. For tickets call 248-9903.
Wild game dinner - 5 p.m., May 3, Bannerville Church of the Brethren. For men and boys. For more information or for reservations, call (570) 765-3955 or 543-5520.
Lewistown Country Club Ladies Golf Association Spring dinner - 5:30 p.m., May 6, Lewistown Country Club. All females who are interested in gold are invited to attend (age 18 or older). To register or for questions, call 436-8068 or 248-8831.
Women's Wellness Workshop - 7:30-11 a.m., Lewistown Country Club, May 10. Doors open for registration at 7:30 a.m., The event is free and for woman older than 13. Preregistration is required by May 5, and can be done by going online to go.geisinger.org/thinkpink or by calling 242-7703. The event is sponsored by Geisinger-Lewistown Hospital.
Annual Lewistown Office State Workers reunion - Noon-2 p.m., May 10, Hoss's, Lewistown. Registration is mandatory and can be done by contacting Margaret Winters at 248-9849 or email@example.com.
Wednesday, April 23
ACTWU-retirees luncheon and meeting - Noon, Moose Family Center. Nominations of officers will take place.
Book sale - 9 a.m.-7:45 p.m., Mifflin County Library community room, Lewistown.
Job fair - 10 a.m.-2 p.m., special veterans time from 9:30-10 a.m., PA CareerLink Mifflin County. Call 248-4942 for more information.
Book sale - 10 a.m.-7 p.m., community room, Historic Mifflin County Courthouse, 1 W. Market St., Lewistown. For more information call 252-1022. Sponsored by the Mifflin County Historical Society.
Growing own herbs workshop - 2 p.m., St. Mark's Episcopal Church, 21 S. Main St., Lewistown. For more information, call 248-8327 or 953-6158.
Mother Goose on the Loose - 10 a.m., Rudy Gelnett Memorial Library, Selinsgrove. Circle time for children ages 3 and younger.
Clothing bank - 10 a.m.-1 p.m., First United Methodist Church, 200 E. Third St., Lewistown.
Knitting group - 10 a.m., Rothrock Branch Library, McVeytown. Call 899-6851 for more information.
Open coffee time - 8:30-11:20 a.m., McVeytown United Methodist Church, Queen Street, McVeytown.
Dollar bag sale - 9 a.m.-1 p.m., The Salvation Army, Lewistown.
Thursday, April 24
Book sale - 9 a.m.-3:45 p.m., Mifflin County Library community room.
Benefit spaghetti supper - 4 p.m., Beavertown fire hall. Cost is: adults, $8; children 5-12, $4; and children younger than 5, free. Sponsored by Middle Creek Valley Council of Churches. The dinner will benefit Malcom Wells and Sandy Digiovanni.
Low Vision Life Skills meeting and support group - 1 p.m., Kish Apartments community room, 196 S. Main St., Lewistown. Dr. Hutton will speak about eye disease. Sponsored by NuVisions Center of Lewistown.
Recycling collection - 3-7 p.m., Beavertown Carnival Grounds.
Spring festival - 6 p.m., New Life Church, Burnham. Sponsored by Panda Preschool and Daycare.
Spaghetti dinner - 4-7 p.m., Milroy White Memorial Church, Main Street, Milroy. Donations benefit Juniata Terrace fire vic-
tims. Sponsored by Milroy Lions Club.
Book sale - 10 a.m.-3 p.m., community room, Historic Mifflin County Courthouse, 1 W. Market St., Lewistown. For more information call 252-1022. Sponsored by the Mifflin County Historical Society.
Breaking Bread Together dinner - 5:30 p.m., St. Mark's Episcopal Church, 21 S. Main St., Lewistown. Dinner is free.
Standard Steel melt shop retirees breakfast - 8:30 a.m., Yetter's, McVeytown.
Aqua Zumba - 9 a.m., YMCA, Burnham. Call 248-5019 for more information.
Knights of the 21st Century meeting - 7:30-9 p.m., Hope Center, Lewistown. Program for men who want to build their moral character. Refreshments provided. Call Tom Stalnaker at 242-8511 for more information.
Griefshare Bible study/support group meeting - 6:30 p.m., Pine Glen Alliance Church. For more information, call Faith Weidman at 899-6972.
KeyStone Gamers - 6-9:30 p.m., Moose Family Center, 80 Brady Lane, Lewistown. Do not have to be a Moose member to join. For more information email firstname.lastname@example.com.
Juniata Area Detachment of the Marine Corps League meeting - 7:30 p.m., American Legion, Mifflintown.
Kish High School Class of 1966 ladies breakfast - 10 a.m., Bread of Life Restaurant, McAlisterville.
Dollar bag sale - 9 a.m.-1 p.m., The Salvation Army, Lewistown.
Friday, April 25
Square and line dancing 6-9 p.m., Messiah Lutheran Church fellowship hall, Mifflintown. Caller is Larry Snook.
Book sale - 9 a.m.-3:45 p.m., Mifflin County Library community room, Lewistown.
Spaghetti dinner - 4-7 p.m., Burnham Lions Club, First Avenue, Burnham. Cost by donation only. Meal is all you can eat. Takeout is available. The dinner benefits Boy Scout Troop 6 of Burnham. Sponsored by the Burnham Lions Club.
Free lunch - 11 a.m.-1 p.m., Family Ministry Center, First Baptist Church of Juniata County, Mifflintown.
Epilepsy Foundation/Central PA Support Group - 6:30-7:30 p.m., classroom four, Geisinger-Lewistown Hospital.
Recycling collection 9 a.m.-1 p.m., Beavertown Carnival Grounds.
Indoor yard sale - 8:30 a.m.-1 p.m., The Salvation Army, 9 S. Dorcas St., Lewistown.
Dollar bag sale - 1-3 p.m., The Salvation Army, 9 S. Dorcas St., Lewistown.
Young adult pizza fellowship - 7-8 p.m., Ritchey's Family Restaurant and Pizza Parlor, Belleville. Sponsored by Big Valley BIC Church. The event is free and open to all young adults 18 and over. For more information, call 436-8010.
Dollar bag sale - 9 a.m.-1 p.m., The Salvation Army, Lewistown.


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|Home | Finance | Grants | Payroll | Auxiliary | Facilities | Information Technology | Procurement
The Taxpayer Relief Act of 1997 provides new tax benefits for persons who are paying higher education costs for themselves and members of their family. Most of these benefits can be claimed when you file your federal income tax return. You may qualify for the Hope Scholarship Credit or the Lifetime Learning Credit.
Your eligibility for the tax credit will depend on your individual circumstances. You may need to contact your tax consultant or the Internal Revenue Service to determine if you are eligible for the tax credits. Shepherd University cannot make this determination for you.
A 1098-T will be mailed in late January to the permanent address of all students for tuition and fee payments. You may also view your 1098-T on RAIL under "Tax Notification." The 1098-T will inform the student or taxpayer of the possibility of a tax credit for payment of eligible tuition and fees under the guidelines of the Taxpayer Relief Act.
It is the responsibility of the taxpayer to determine eligibility for the credit. For more information concerning the Tax Relief Act, call the Internal Revenue Service at 800-829-1040 or visit their website.


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Here's the forecast for Grand Rapids. Check the latest update.
Today: Scattered showers and thunderstorms. Mostly cloudy, with a high near 70. West southwest wind between 6 and 9 mph. Chance of precipitation is 30 percent.
Tonight: Mostly cloudy, with a low around 54. West northwest wind between 3 and 7 mph.
Friday: Partly sunny, with a high near 77. Northeast wind around 5 mph becoming south southeast.
Friday Night: A slight chance of showers, then showers likely and possibly a thunderstorm after 2 a.m. Mostly cloudy, with a low around 62. East northeast wind around 7 mph. Chance of precipitation is 60 percent. New rainfall amounts of less than a tenth of an inch, except higher amounts possible in thunderstorms.
Here's the forecast map from Accuweather.com:


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We're down to the Final Four in the 2013 NCAA tournament, leading us to recall some of the great games that took place in the national semifinals.
Although the national championship game gets most of the attention in history books, we focus here on the Final Four, which has given us just as many riveting contests, if not more.
Games in six different decades are included in our countdown of the top 10 NCAA tournament semifinal games of all time.
We hedged a bit in our rankings. Special mention is given at the outset to one game that is not included in our top-10 countdown, and the No. 10 spot is shared by two games that deserved inclusion.


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Harrisburg police said John Lumpkins, 53, died Saturday after being shot near Dewberry and Blackberry streets.
Lumpkins walked into The Pub bar about 11:30 p.m. Saturday and saw his estranged with with 40-year-old Theodore Meriweather Jr., police said.
The couple left, Lumpkins followed and argued with Meriweather, who shot him, police said.
Meriweather is in Dauphin County Prison charged with criminal homicide.
This is the 11th homicide in Harrisburg this year.


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UH Manoa Campus Events Calendar
A Workshop on Local Ecological KnowledgeFebruary 28, 2:30pm - 5:30pm
Manoa Campus, Moore Hall, Room 575
The bodies of knowledge, skills, practices, and beliefs that communities around the world develop in connection to their local environments---collectively known as "local ecological knowledge" (LEK)---are often the object of study of physical sciences like botany and zoology, but they do not usually enter into the discourses of fields such as the social sciences, the arts (visual, performing, and literary), the humanities, and education, among others. This interdisciplinary workshop will allow participants not only to engage in discussions about LEK, but also to collaborate in hands-on, data-oriented, and solutions-based activities.
The workshop will take place on February 28 and March 1, 2014 at the University of Hawai'i at Mānoa. Featured guest presenters from Aotearoa (New Zealand) and the Mortlock Islands in Chuuk State will discuss topics such as the emergence of LEK in performance and the experiential learning of LEK by children. The workshop is free, but seats are limited due to seating restrictions of the venue. Please contact Emerson Odango (firstname.lastname@example.com) before registration closes on January 31, 2014 for RSVPs.
Event Sponsor
Linguistics, Botany, and the Lyon Arboretum, Manoa Campus
More Information
Emerson Odango, 757-419-6030, firstname.lastname@example.com
|Friday, February 28
|A Workshop on Local Ecological Knowledge
Manoa Campus, Moore Hall, Room 575
|Ka Papa Loʻi ʻO Kānewai Mālama Hāloa Kalo Festival
Manoa Campus, Kamakakuokalani Bldg (KAMA) 110
|Employing Pacific Studies: PhD Pathways
Manoa Campus, Tokioka Room, Moore 319
Manoa Campus, Various buildings, see website
|Aloha Friday with SPAM!
Manoa Campus, QLCSS #208
|Education Final Oral
Manoa Campus, Wist 129
|German Club - Stammtisch
Manoa Campus, Manoa Gardens
|A Workshop on Local Ecological Knowledge
Manoa Campus, Moore Hall, Room 575
|Building Aboriginal Territories in Cyberspace
Manoa Campus, Saunders 624
|EALL Talk Series 3 - Dr. Jeong-Seok Kim
Manoa Campus, Center for Korean Studies
|Improving Intercultural Service Encounters in Restaurants
Manoa Campus, Queen Lili'uokalani Center for Student Services 412
|It's not about libraries! It's about learning!
Manoa Campus, Hamilton Library room 3F
|Movie Night: Hunger Games Catching Fire
Manoa Campus, Campus Center Ballroom
|Jeremy Wong, baritone
Manoa Campus, Orvis Auditorium
|Lady Mu and the Yang Family Generals
Manoa Campus, Kennedy Theatre Mainstage
|Movie Night: Hunger Games Catching Fire
Manoa Campus, Campus Center Ballroom
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.


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Easy 30-Minute Recipes
Easy recipes, doable beauty tips, a 30-day fitness guide, and so much more in the September issue of Good Housekeeping Philippines, out now.
Like any girl who gets a kick out of seeing dreamy dresses parade down the red carpet, I spent a major part of Monday morning checking out what the stars wore at the 2014 Golden Globe Awards. In my fashion-obsessed mind, getting to wear gorgeous designer creations straight out of the catwalk is the best thing about being a celebrity (rubbing elbows with Tom Hiddleston and Benedict Cumberbatch comes a close second).Continue Reading >>
Alexa Chung: the fringed beauty with legs for days, whose ensembles never fail to make it to the "looks to copy" folder in my head. The English-Chinese charmer whose sense of humor and outspoken personality are just as famed as her boy-girl stance on dressing; who pretty much stole the hearts of everyone in the fashion and beauty industry, what with a namesake designer bag, numerous magazine covers, and countless endorsements under her belt.Continue Reading >>


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Pregnant Women To Be Tested For Smoking In UKSierra Black
The United Kingdom's National Institute for Health and Clinical Excellence wants to test all pregnant women to see if they've been smoking. Any woman who tests positive for smoking will be offered help and counseling on how to stop.
Woah. That's a sticky wicket. Midwives in Britain are protesting the move, saying it will make pregnant smokers feel guilty. Which on the one hand is true, and on the other hand, maybe they should?
There are real, lasting health issues for mother and child when a woman smokes during pregnancy. Shouldn't women be advised about these risks and supported in stopping?
Obviously, yes. But mandatory drug testing is a pretty disrespectful way to "help" expectant moms give up their cigs. As Feministing puts it:
This doesn't just make women feel guilty, the assumption is that that she is guilty – and that pregnant women can't be trusted to tell the truth about their health and habits to their doctors.
Yes, smoking is bad for women and for babies, and in some ways particularly bad for pregnant women and unborn babies. I can't even argue that women who smoke are exercising their freedom of choice to do so. Tobacco companies spend big money coercing people to make terrible choices for themselves and their families, creating addictions that left unchecked will kill their users. There's a strong argument to be made for intervening and helping someone who's been sucked into that system, whether they want the help or not.
However, I've been a pregnant woman. I'll never forget the liquor store clerk who busted me buying non-alcoholic beer for a holiday party and asked me to pray to God for the strength to resist my depraved impulse to drink the stuff. I mean, yes, non-alcoholic beer is repulsive, and my craving for it was depraved. But not because it contains a tiny residual amount of alcohol.
There's a kind of public hysteria about what women do with their bodies during pregnancy that I simply can't endorse. Yes, we're creating the future in our wombs. But you'll just have to trust us to do it in an ethical, healthy way. My body doesn't become public property just because I'm growing a child in it.
The problem with that approach is the same as with so many legistlative impulses: where do you stop? I want no pregnant women to smoke. But start down that road and you quickly end up in murky territory about what women can do when they're pregnant.
I'm a vegetarian, and I'd hate to have my diet legislated. I wouldn't want to be barred from playing sports because they might pose a risk to my fetus, or required to take prenatal vitamins.
What do you think? Does the state have a vested interest in protecting the unborn from secondhand smoke, or is this stomping on pregnant women's rights?
Photo: Malias


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Shoyoroll Batch 12
Just got another awesome e-mail from Shoyoroll about their Shoyoroll Batch 12 gis!
Here's a Sneak Peek at Shoyoroll Batch 12!
One of our artist series release by homegrown NYC based artist John Smalls. The designs and color ways are influenced by the birth place of BJJ (Rio De Janiero, BRAZIL) and design pattern blend of a Japanese inspired Koi with a Water Dragon (2012). We will also be featuring pattern
art hits in different parts of the kimono.
Rio Koi Specs:
- Lightweight Standard Pearl Weave Jacket
- 10 oz Drill Cotton Pants with Gold Weave Gusset
- Color ways of White with Green and Yellow Trims
This is our first athlete series release of 2012. We are introducing our Brand New PRO Pearl Weave Fabric along with our new lightweight Poly/Cotton Blend pants that are both light and durable offer amazing blend for guard players and competitors.
The Ring Specs:
- Lightweight PRO Pearl Weave Jacket
- Lightweight Poly/Cotton Pants
- Color ways of Black with Purple and Grey Trims
Anybody thinking of picking up one of the Shoyoroll Batch 12 gis? Really interested to hear more about The Ring and how it's good for guard players.


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Home > Business Management > Human Resources > Human Resource Management > White Paper case studies
Company: GoToAssist
| Category: Human Resource Management
| Published: April 2012
There are no shortcuts to good hiring. But with the right process in place, you can have an all-star support team in due time.
"The skills people need to be successful support agents are not always evident from a resume."
This article shows you how to build a sustainable process for hiring the very best people for your support team
Download the article to learn:
• How to shift your focus from pedigree to aptitude
• Three goals for screening candidates over the phone
• Why your team should participate in the interview
• And more...
Rating: + 2
Call Centre Services | January 2013 | White Paper
Help Desk Management | January 2013 | White Paper
Employee Performance Management | October 2012 | White Paper
Customer Relationship Management (CRM) | July 2012 | White Paper
Help Desk Management | January 2012 | White Paper
© Incisive Business Media (IP) Limited 2016, Published by Incisive Business Media Limited, Haymarket House, 28-29 Haymarket, London SW1Y 4RX, are companies registered in England and Wales with company registration numbers 9177174 & 9178013.
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Created in this Craftsy class
Get piecing in no time with Anita Grossman Solomon's innovative techniques for cutting and assembling four classic quilt blocks.
Other projects made as part of this class:
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
|Here are some details about my project:
|Classic, Whimsical, Traditional, Casual
What materials did you use? Scrap material from old clothes, Niagara starch, thread from the my mom's ancient thread rack, templates cut from cardboard (until I buy the real ones)
What are you most proud of? This may seem strange, but I'm usually not one to follow directions very closely. I am one to just create in whatever way I think might work. This is how I make jewelry, paint and create other art. Quilting was one of those skills that I planned to just figure out. I am SO glad that I recognized that creating special quilts that I hope to be passed on for generations required that I learn from an expert.
What advice would you give someone starting this project? I would just encourage anyone who even thinks they might like to learn to quilt to give this course a try. Even if you have quilted before, you may learn some new ways of accomplishing tasks that you already know how to do. I think you will find her suggestions to be very informative and fun.
Amazing! I love the colors!
Thank you for sharing your block. I too just love this class...I watched it all yesterday, and am already anxious to start a quilt using this amazing technique. Using This technique is not the "usual" way one makes a quilt!


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November 06, 2001
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Album Review
This multimedia box set celebrates the 17-year affiliation between Dead Can Dance and the alternative-friendly 4AD label. In addition to key album tracks, Dead Can Dance 1981-1998 contains a handful of previously unissued performances spread over three audio discs. Also included is a single-sided video DVD containing the Mark Magdison documentary Toward the Within, as well as six promotional music videos. Few pop music artists define themselves by virtue of reinvention. However, the mere existence of Dead Can Dance is firmly entrenched upon an evolutionary amalgam of the '80s noir industrial scene with sonic styles and patterns indelibly rooted in world music. Although augmented by various supporting musicians, at the creative and artistic center of Dead Can Dance has remained the team of Brendan Perry (guitar) and Lisa Gerrard (vocals). Possessing an uncanny combination of punk D.I.Y. mentality with an ethereal sense of instrumentation and delivery, the duo forged new boundaries ranging in style from European folk -- from the Middle Ages and Renaissance most specifically -- to very contemporary-sounding worldbeat. Their seven studio albums and Garden of the Arcane Delights EP are amply represented during the three-and-three-quarter-hour running time. These include tracks such as "The Song of the Seraphim," "The Carnival Is Over," "Sanvean," "American Dreaming," and "The Ubiquitous Mr. Lovegrove" -- an initial college radio hit that became the group's entrée into alternative rock. Among the rarities is a complete John Peel session recorded on November 19, 1983, for broadcast by Peel nine days later. Two of the performances -- "Labour of Love" and "Orion" -- are previously unissued tunes. Other radio rarities include "Sloth" and "The Wind That Shakes the Barley" from Perry and Gerrard's August 10, 1993, appearance on KCRW's Morning Becomes Eclectic. The DVD is a dual-layer disc containing the 70-minute Toward the Within performance documentary as well as the promo videos for "The Carnival Is Over," "The Host of the Seraphim," "Yulunga (Spirit Dance)," "Frontier," and "The Protagonist." For both the casual enthusiast -- not looking to invest in every album -- as well as the completist, the sonic and visual breadth covered on this compendium go far beyond A Passage in Time -- the only other compilation featuring the insightful works of this tragically underrated band.
Lindsay Planer, Rovi
Track Listing
Frontier [Demo Version]
Labour of Love [Radio Edit]
Ocean [Radio Edit]
Orion [Radio Edit]
Threshold [Radio Edit]
Carnival of Light [Radio Edit][#]
In Power We Entrust the Love Advocated
De Profundis (Out of the Depths of Sorrow)
Enigma of the Absolute
Summoning of the Muse
Anywhere Out of the World
In the Kingdom of the Blind, the One-Eyed Are Kings
The Protagonish
The Host of Seraphim
Song of Sophia
The Arrival and the Reunion
Black Sun
The Promised Womb
The Song of the Sibyl
The Ubiquitous Mr. Lovegrove
Sloth [Radio Edit][#]
The Carnival Is Over
The Spider's Stratagem
The Wind That Shakes the Barley [Radio Edit][#]
How Fortunate the Man With None
I Can See Now
American Dreaming
Don't Fade Away
Song of the Nile
The Snake and the Moon [Edit]
The Lotus Eaters [#]
Toward the Within (A Mark Magidson Film)
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It could seem as if you are stuck in a rut and this could leave you feeling bored with the way things are. Although it is natural to stick to a routine, it may feel like nothing is moving forward in your life and this might make you want to go out and try something new and different. Perhaps today you can consider the small ways in which you can change your usual patterns. Even something as simple as finding a new way to get to work, trying something new to eat, or adding a new form of exercise can help you feel more in control of your life and see that it is not so difficult to step out of your everyday activities and be different. The small changes may not seem significant, but they can lead you to much more far-reaching transformations.
The changes that truly affect our lives are usually the result of a gradual process of adjustments and modification. Although our lives will seem more intriguing if things happen dramatically, there is actually very little in life that tends to change so much from day to day. Once we realize this we can work toward altering our routine little by little so that each day will bring us new experiences. It is in this way that we are really able to add lasting and also positive changes to our lives. Making just a few small alterations to your routine will infuse your routine with a greater amount of interest and excitement today.
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But this weekend belonged to Tony Kanaan, who won Sunday afternoon's race at Iowa Speedway.
The victory enabled the 35-year old Brazilian to snap a winless drought that spanned 33 races, dating back to the Richmond race in 2008.
In fact, Kanaan's Andretti Autosport team became the first non Penske or Ganassi team to win on an oval since that Richmond race two years ago.
Kanaan passed eventual runner-up Helio Castroneves with 10 laps to go and eventually won by 4.2 seconds.
It has been so long since Kanaan has been in Victory Lane that I forgot how much fun his interviews are.
"Helio just brought me back so many memories," Kanaan said in the post-race news conference. "It has been 25 years that we have been racing against each other. I was trying not to hit him because we have to fly back home together. It would have been an awkward flight."
It is back to the road courses for IndyCar, which will return to action with the July 4 Camping World Grand Prix at The Glen. It's the beginning of five consecutive road course races for IndyCar. The final four events will be held on ovals.
Odds & ends
• Jimmie Johnson's victory at Sonoma, Calif., on Sunday was his first on a road course and the 51st of his career.
• Sunday's win at Bristol was the 130th for John Force, and it enabled him to take over first place in the National Hot Rod Association's Funny Car division.
• The NASCAR Nationwide Series ran its inaugural race at Road America Saturday, and Carl Edwards won his first race of the season after dominating action.
• Larry Dixon has been all the talk in Top fuel in recent weeks, but Tony Schumacher, the six-time defending champion, defeated Brandon Bernstein in the finals. It was Schumacher's fourth win of the season, and it enabled him to slice into Dixon's points lead. Schumacher trails Dixon by 123 points after being down by 199 heading into Bristol.
Quote of the week
"For some reason, he just turned me around. So, that's alright. What comes around, goes around. These guys don't have any respect for me, I'm going to have none for them. We will get them at Loudon." Martin Truex Jr., on his altercation with Jeff Gordon at Sonoma.
So much for all the love that was going around at Michigan last weekend.


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The PIAA website offers some interesting details about high school sports in Pennsylvania.
For instance, 735 PIAA schools play boys' basketball, 422 play girls' tennis, and 588 have football teams.
No numbers are listed for water polo, and the site's water polo page is practically blank.
That's because there are few PIAA water polo teams - 22 for boys, 21 for girls - so few that the organization doesn't sponsor championships in the sport.
The numbers don't seem significantly better among non-PIAA schools, either. Safe to say, Pennsylvania isn't ready to compete with California for water polo supremacy.


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Please click on the link below to download the latest version. Thanks!
Saudi Arabia detained a vulture tagged by Tel Aviv University and accused Israel's Mossad secret service of sending the bird to spy, according to a report in a Saudi newspaper.
The report in Al-Weeam said the vulture was wearing a leg bracelet and transmitter and was found in a rural area of the country. It appeared to be what it called "a Zionist plot," the paper added.
The report spawned a number of posts on Arabic websites claiming the "Zionists" had trained the birds for spying.
Last month, an Egyptian official accused Israel's Mossad of intentionally releasing a shark that killed a tourist in the waters of the Egyptian resort area of Sharm el-Sheikh to sabotage their tourism.
But internationally renowned ornithologist Dr. Yossi Leshem, from Tel Aviv University in Israel, said the vulture was part of a study tracking the movement of the birds because they are becoming extinct in Israel.
"It has nothing to do with the Mossad or the Shabach [Israel Security Agency]," Leshem told CBN News.
The Griffon Vulture now in Saudi Arabia was caught in 2008 at the Ramon Crater in the Negev Desert in southern Israel by a Hebrew University student Orr Speigel.
Six years old when it was caught, the bird was tagged with an R26 wing tag and metal ring marked TAU - [Tel Aviv University], Israel, and set free, a posting on a birding website in which the university participates.
Since then, the vulture has been sighted several times in Israel and in September 2010, a GPS device was mounted on its back enabling researchers to use satellite tracking to monitor the bird's behavior.
"The research examines the effectiveness of the feeding stations that are maintained throughout Israel, with the aim of improving the conservation efforts made to stabilize the status of this endangered species," the website said.
Saudi birders caught the vulture, and Leshem said they contacted Tel Aviv University researchers through a third party.
"They feared it had been sent deliberately by the Israeli Mossad and that the tracking device on its back is in fact a method of spying," the website said.
"The vulture is currently held captive by Saudi authorities, while Israel nature conservation authorities…are making great efforts to convince those involved to release it," it added.
Leshem told CBN News that it's not the first time one of the Israeli tagged birds has been accused of espionage.
In two separate incidents, a pelican and an Egyptian vulture tagged by Tel Aviv University have been found in Sudan. Both times the local media claimed Israel was using the birds for spying and appeals by the University to retrieve the transmitter on the vulture itself were refused by the Sudanese authorities, Leshem said.
Nevertheless, Leshem noted that birding had actually been used in the past as a tool for regional cooperation.
"Migrating birds know no boundaries," a booklet emailed to CBN News on a 15-year joint Israeli, Palestinian and Jordanian project stated. Leshem was involved in the project.
"Between 1998 to 2004: Palestinian, Israelis and Jordanian schools learned about bird migration by following 120 German White Storks that were carrying satellite transmitters," it said. "Palestinian, Israelis and Jordanians also developed joint activities such as bird banding stations and much more."
The Jerusalem Post contributed to this report.
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The Terrorists Funded by the WestBassam Tawil
The New Israel Fund and those who support it are helping terroristsRonn Torossian
Column one: Fighting fire with fireCaroline B. Glick
Op-Ed: There is no 'radical Islam' and there is no 'moderate Islam'Dr. Mordechai Kedar
'Narrow' escapesRuthie Blum
Why Palestinians Do Not Want Cameras on the Temple MountKhaled Abu Toameh
Social Media Killed My FatherYoni Kempinski and Ari Soffer
Iran's New Palestinian Terror Group: Al SabireenKhaled Abu Toameh


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$50 Tee Time Specials Credit
$50 $25 50% off
- $50 credit toward any Tee Time Specials on EZLinks.com
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What we love
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- EZ Links was created to provide golfers with access to tee times at golf courses all over the world.
- The company operates on your schedule, allowing users to book a tee time up to 12 days or just hours in advance.
What to know
- Redeem by: Thursday, October 3, 2013
- This offer is subject to Terms and Conditions
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S Doradus star
A massive, blue supergiant variable star, also known as a Hubble-Sandage variable or a luminous blue variable. S Doradus stars are the most luminous stars in the Galaxy and are easily identified in other nearby galaxies, including the Andromeda Galaxy and the Triangulum Galaxy. They are named after the prototype, S Doradus, in the Large Magellanic Cloud.
Related entry• variable stars
Related category• TYPES OF STAR
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Construction: Construction and civil engineering company operating through three divisions. The construction division carries out civil engineering and constructs engineering structures and buildings, including tunnels, bridges and commercial, industrial and residential buildings. The services and property development division provides land prospecting, legal and financial engineering and facility management services to the property sector as well as operating car parks. The prefabrication division manufactures concrete products for the construction sector, including framework, pre-stressed girders, tunnel linings, staircases, facades and noise barriers
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What is in this article?:
- Washington, D.C. rewards persistence of agriculture
- Honorary award well deserved for Harry Cline
- "Given the present legislative gridlock, I would not expect much change any time soon. However, Washington is a place that rewards persistence and repetition instead of new ideas, and NAFA's efforts may well bear fruit over time."
More About:
Members of the alfalfa and forage industry around the country traveled to Washington, D.C. in February to take part in a Fly-In hosted by the National Alfalfa and Forage Alliance. CAFA was represented by board member Philip Bowles of Bowles Farming in Los Banos, Calif., who summed up the event below.
"This year I represented CAFA at the National Alfalfa and Forage Alliance Board meeting and annual Fly-In in Washington, D.C., held Feb. 12-14. NAFA is a nationwide umbrella organization composed of genetic suppliers, equipment and chemical manufacturers, and hay and seed grower organizations, all with a common aim: to promote the well-being of the hay and forage industry, and to educate the public (including government) about the importance of forage crops. Because alfalfa is grown in so many states, under so many conditions, what might seem like good policy for one region may not be useful or welcome in another. This point was drawn out clearly in the board meeting, where the majority of grower groups politely said 'No thank you,' to tentative proposals seeking to be included in the Title I 'shallow loss' subsidy program.
"However, we approved of the organization working with the Federal RMA to craft a crop insurance program that could be of use to growers in certain areas. Following this, sub-groups spent two days calling on a variety of congressional and regulatory offices, 'consciousness-raising' and asking that the pitiful level of federal funding for alfalfa research be raised to something approaching that of the 'program crops' (corn and soybeans) each of which receives over 10 times the level of annual research funding that alfalfa does. (Not to mention the subsidies those producers receive!) Given the present legislative gridlock, I would not expect much change any time soon. However, Washington is a place that rewards persistence and repetition instead of new ideas, and NAFA's efforts may well bear fruit over time."