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Associate Controller
Princeton University in New Jersey
|Date Posted
|August 8, 2014
|Not specified
|Employment Type
The Finance & Treasury division of Princeton University seeks an experienced professional to direct financial and accounting activities and be a part of a leadership team helping to guide the University through a major systems transformation.
The Associate Controller reports to and assists the Controller in establishing and implementing the accounting policies of the University. S/he oversees the preparation of the University's audited financial statements, manages the requirements of the annual external audit, and has responsibilities for property and plant accounting, debt program accounting and administration, reconciliation and analysis of various accounts, and certain tax compliance duties. The Associate Controller is also responsible for meeting numerous financial reporting demands for internal management, budgeting, regulatory, fiduciary, industry, and tax reporting purposes.
The Associate Controller directs a managerial staff of three (and total staff of seven). The person in this position collaborates with internal and external parties to complete various audits, compliance reports, etc. S/he position manages numerous deadlines (general ledger closings, board materials, financial statement filings, survey filings) throughout the year.
Primary duties include:
- Prepare the annual financial statements of the University and various affiliated entities in accordance with generally accepted accounting principles. Evaluate new authoritative accounting pronouncements, assess their impact on the University's financial statements, and coordinate their implementation. Develop and implement accounting policies and procedures. Support the Finance & Treasury division with expertise on technical accounting matters. Manage the year end closing process.
- Coordinate and manage the annual external audit of the University's financial statements and ancillary audits including the retirement plan, the athletics department, and government sponsored programs, among others. Assess and manage the impact of new generally accepted auditing standards, AICPA guidance, and government audit standards applicable to federal and state sponsored programs. Coordinate the documentation and assessment of internal controls over financial reporting.
- Prepare financial and operational reports, surveys, reconciliations and analyses for various governmental agencies, industry publications, continuing disclosure repositories for debt securities, tax reporting, and various internal financial management and budgeting purposes.
- Design, implement, maintain and operate accounting and reporting systems including the University's PeopleSoft Financials general ledger, certain feeder systems, interfaces, and journals, as well as the chart of account structure and information warehouse reporting tool. Ensure that such systems meet various management and regulatory reporting requirements imposed by GAAP, tax, sponsored programs and donor restrictions.
- Direct various financial and accounting activities with a managerial staff of three (and total staff of seven) in the Controller's Office including: property and plant accounting; debt program accounting, administration and bond issuance; bank account administration and reconciliations; inventory, agency and suspense account reconciliations; and certain tax compliance responsibilities such as Form 990 reporting and escheat, among others.
Position Requires:
- Bachelor's degree
- 7 to 10 years of public accounting and/or industry work experience.
- Demonstrated ability to handle multiple assignments and respond quickly to changing business needs and priorities
- Strong organizational skills, attention to detail, and the ability to manage multiple projects and deadlines effectively
- Effective supervisory experience
- Leadership skills
- Accounting experience with complex not-for-profit organizations and government sponsored programs
- Master's degree in business
The final candidate will be required to successfully pass a background check.
To apply, go to: http://jobs.princeton.edu, and submit cover letter and resume to Requisition #1400537.
Princeton University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status or any other characteristic protected by law.


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Florist: Designer duped me out of moneyUPDATED 7:29 AM EST Feb 14, 2013
A Baltimore florist claims she was scammed out of thousands of dollars by someone she hired, and 11 News I-Team reporter Barry Simms discovered she may not be the alleged thief's first victim.
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subset: commoncrawl


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Sequel to Guillermo Del Toro's 'Pacific Rim' already in the works
Guillermo Del Toro's "Pacific Rim" may not be hitting theaters until July, but the studio behind the film is already gearing up for a sequel.
Legendary Pictures has drafted original writer Travis Beacham ("Clash of the Titans") and Del Toro to co-write the script for a follow-up to the forthcoming tentpole, which centers on a group of "robot pilots" who must use their skills to save humanity from an invasion by giant otherworldly monsters (via The Hollywood Reporter).
So will Del Toro return to direct? That all depends on Legendary's timetable for the potential sequel, as he's already on board to helm their Gothic haunted house movie "Crimson Peak," which is currently being eyed for a January 2014 start date.
Of course, whether a follow-up gets the greenlight all depends on how "Pacific Rim" fares at the box-office next summer. It's slated for release on July 12.
Will you be seeing "Pacific Rim"? Let us know in the comments.


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The Legacy Giving Society is a group of like-minded individuals who want to ensure that the mission of Special Olympics Kentucky continues to change lives for generations to come.
Legacy Giving Society members know what a difference Special Olympics Kentucky makes in the lives of the over 6,600 athletes that participate throughout the state every year. They are committed to making better lives for these athletes by supporting the year-round sports training and competition that Special Olympics Kentucky provides. They know the importance of promoting healthy lifestyles and they financially support the Healthy Athletes initiative. They have made a commitment to promote
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Please contact us with any questions, comments or problems at firstname.lastname@example.com


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OPPENHEIM, N.Y. (AP) — A national rescue group is helping relocate nearly 100 dogs from a small house in rural upstate New York to shelters across the state.
The American Society for the Prevention of Cruelty to Animals is coordinating the effort to remove dogs from Help A Hound, an animal shelter operating in a 1,050-square-foot house in the Montgomery County town of Oppenheim, about 50 miles northwest of Albany. Breeds include pit bulls, basset hounds, bulldogs, Chihuahuas and shepherd-lab mixes.
Jeff Eyre, an ASPCA investigator, says Thursday some of the dogs are underweight and have various medical problems.
The ASPCA says Help A Hound's owner, Veronica Thompson of Fitchburg, Mass., gave up the dogs but the local SPCA lacked the resources to care for them. Other shelters from around the state stepped in to take dogs and find homes for them.


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Reptational dynamics in dissipative particle dynamics simulations of polymer melts
Nikunen, Petri; Vattulainen, Ilpo; Karttunen, Mikko
Publication type: Artikkeli - Article
Issue date: 2007
Citation: Nikunen, P., Vattulainen, I. & Karttunen, M. 2007. Reptational dynamics in dissipative particle dynamics simulations of polymer melts. Physical Review E 75 pp. 036713-1 - 7.
Belongs to: Physical Review E
University: Tampereen teknillinen yliopisto - Tampere University of Technology
Faculty: Teknis-luonnontieteellinen osasto - Department of Science and Engineering
Department: Fysiikan laitos - Institute of Physics
Understanding the fundamental properties of polymeric liquids remains a challenge in materials science and soft matter physics. Here, we present a simple and computationally efficient criterion for topological constraints, i.e., uncrossability of chains, in polymeric liquids using the dissipative particle dynamics (DPD) method. No new length scales or forces are added. To demonstrate that this approach really prevents chain crossings, we study a melt of linear homopolymers. We show that for short chains the model correctly reproduces Rouse-like dynamics whereas for longer chains the dynamics becomes reptational as the chain length is increased—something that is not attainable using standard DPD or other coarse-grained soft potential methods.
Copyright: This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Copyright (2007) The American Physical Society
Copyright (2007) The American Physical Society


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Author Affiliations: National Center for Children in Poverty, Mailman School of Public Health, Columbia University, New York, NY (Dr McLearn and Ms Marks); and Department of Population and Family Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md (Drs Minkovitz and Strobino and Mr Hou). Dr McLearn is currently with Center for Children's Healthcare Improvement, Department of Pediatrics, University of North Carolina, Chapel Hill. Ms Marks is currently with Population Health Division, Research Centre of the University of Montreal Hospital Centre, Montreal, Quebec.
To determine whether maternal depressive symptoms, reported when infants are 2 to 4 months old, are associated with mothers' early parenting practices.
Secondary data analyses collected from the National Evaluation of Healthy Steps for Young Children. Data sources included newborn enrollment questionnaires and parent interviews when infants were 2 to 4 months old. Maternal depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale.
Twenty-four pediatric practices across the United States.
A total of 5565 families enrolled in Healthy Steps; 4874 mothers (88%) completed 2- to 4-month interviews and provided Center for Epidemiologic Studies Depression Scale data; 17.8% of mothers reported having depressive symptoms.
Main Outcome Measures
Ten parenting practices assessed in 3 domains: safety (sleep position and lowering water temperature), feeding (cereal, water, or juice; continuing breastfeeding), and practices to promote child development (showing books, playing with infant, talking to infant, and following 2 or more routines).
Mothers with and without depressive symptoms reported similar uses of safety and feeding practices. Mothers with depressive symptoms had reduced odds of continuing breastfeeding (adjusted odds ratio [AOR], 0.73; 95% confidence interval [CI], 0.61-0.88), showing books (AOR, 0.81; 95% CI, 0.68-0.97), playing with the infant (AOR, 0.70; 95% CI, 0.54-0.90), talking to the infant (AOR, 0.74; 95% CI, 0.63-0.86), and following routines (AOR, 0.61; 95% CI, 0.52-0.72).
Maternal depressive symptoms are common in early infancy and contribute to unfavorable parenting practices.
Depression is a prevalent health problem among women of childbearing age, with mothers of infants and young children being at particular risk in part because of the routine demands of parenting.1 Prevalence rates vary depending on the population being studied. The prevalence of depressive symptoms among mothers of children younger than 3 years ranged from 19% to 24% in 2 nationally representative US samples.1,2 For low-income mothers with young children, depressive symptoms are more prevalent,3- 5 whereas longitudinal studies of pregnant and postpartum women consistently find that 9% to 12% of mothers have depressive symptoms.6- 8
Many investigators, using both observational and interview methods, have demonstrated that maternal depressive symptoms are related to adverse caregiving and health-related behaviors, which in turn influence children's health and development.9- 12 A meta-analysis13 of small direct-observation studies found associations between maternal depression and impaired parenting, especially among mothers of infants. Depressed mothers were less likely to engage in positive behaviors during play and feeding opportunities and were more likely to be disengaged and display higher levels of hostile behaviors.
In large national samples, investigators reported that mothers with depressive symptoms engaged in poorer preventive health practices with their toddlers, such as decreased use of car seats and electrical outlet covers.2,14 Maternal depressive symptoms have been associated with lower levels of positive parent-child interactive behaviors, such as playing, reading, following routines, and cuddling, and higher levels of negative behaviors, such as being irritable, yelling or spanking in the first 3 years of life, and decreased use of health care seeking for their young children.1,2,5,15
Only a few large studies have focused on maternal depressive symptoms in the postpartum period and their association with early parenting behaviors. Using a community sample of low-income women, the presence of postpartum depressive symptoms was associated with decreased odds of having a smoke detector or placing the infant on his or her back to sleep and increased odds of using corporal punishment during the first year of life.5 Smaller direct-observation studies have found that depressed mothers were less likely to engage in positive developmental behaviors during early interactions, such as talking, playing, or being affectionate with their newborns, and were more likely to display anger and disengagement.16- 18
The science of early development is clear about the importance of parenting and early caregiving relationships, especially during infancy, when there is total dependency for safety, health, protection, nurturing, and stability.9,11 Infants' early development also depends on the health and well-being of their parents. When a mother is coping with postpartum depressive symptoms, it places a burden on the caregiving relationship at a time when early patterns of parenting are established.9,11,19 Despite this fact, we are unaware of any studies that have used a diverse, large nationwide sample to determine whether the presence of depressive symptoms in mothers is associated with a broad array of caregiving practices related to health and development in the postpartum period.
In this study, we examined whether maternal depressive symptoms at 2 to 4 months post partum are associated with parenting practices in a large nationwide sample of mothers and infants. We posited that depressive symptoms exhibited in the early months of caring for an infant were associated with lower levels of engagement in positive parenting behaviors to promote child health and development. The diversity and size of our sample allowed us to address limitations of smaller studies and adjust for possible confounders of the relationship between maternal depressive symptoms and parenting practices. We examined 10 parenting practices that fall into 3 domains: safety practices, feeding practices, and behaviors that promote early development. Extensive evidence, professional guidelines, and the American Academy of Pediatrics (AAP) policy statements highlight the importance of these practices.11,20- 27
Data for this study were obtained from a sample of intervention and control group families at 15 sites across the United States that participated in the National Evaluation of Healthy Steps for Young Children.28 Healthy Steps is a new model of pediatric care that incorporates child development specialists and enhanced developmental services into pediatric practices that serve families with young children. The design was a randomization trial at 6 sites (up to 400 enrolled) and quasi-experimental at 9 sites (up to 200 enrolled at the intervention site and 200 at the comparison site). Sites began staggered enrollment in September 1996 with completion at the last site in November 1998.
Newborns whose families intended to use the Healthy Steps sites for their care were enrolled consecutively in the hospital at birth or at the first office visit within the first 4 weeks of life. Newborns were ineligible if they did not complete an office visit within the first 4 weeks, they were to be adopted or placed in foster care, their mother did not speak English or Spanish, or their parents expected to move within 6 months. The eligible sample for the analyses reported in this article included mothers who completed forms at enrollment and a telephone interview at 2 to 4 months and who provided self-reported data of depressive symptoms using a 14-item modified Center for Epidemiologic Studies Depression Scale (CES-D) at 2 to 4 months.
Two data sources, available in English and Spanish, were used. The first was a short questionnaire completed by parents at the time of entry into Healthy Steps; this questionnaire provided maternal and family demographic characteristics. The second was a computer-assisted Healthy Steps telephone interview conducted with the mother (virtually all respondents) when the child was 2 to 4 months of age. The structured interview included questions about the presence of depressive symptoms, early parenting practices, and additional demographic characteristics.29
The 10 early parenting practices included in this study were selected from 17 parenting practices included in the Healthy Steps interview. They were selected based on evidence of their importance for child health and development, near complete data, and variability at 2 to 4 months. Two dichotomous variables were chosen to assess infant safety practices: using the prone sleep position at both naptime and bedtime and lowering the temperature of the hot water heater in the home. Placing an infant to sleep in the supine or stomach position is associated with sudden infant death syndrome, the leading cause of postneonatal mortality in the United States.30 Since 1992, the AAP has recommended that newborns be placed on their backs to sleep.21 Lowering the hot water temperature is an important preventive safety measure to decrease tap water scald burns, especially among infants and young children.25,31,32
The 4 infant feeding practices included continuation of breastfeeding at 2 to 4 months among mothers who had ever put the infant to the breast and whether or not the infant had been given water, juice, or cereal during the last week. The AAP advises that breast milk or infant formula provides sufficient nutrients in the first 4 to 6 months. Breastfeeding is associated with decreased infectious and chronic diseases and has shown a modest positive influence on infant cognitive development.24,33 The early use of juice in the diet can result in insufficient nutrition, dental caries, and short stature34; early water use is associated with electrolyte imbalance and can lead to water intoxication and even death35; and there is no nutritional indication to introduce cereal before the age of 4 months.36 Four practices to foster healthy development included showing books daily to the infant, playing daily with the infant, talking daily to the infant while working in the home, and following 2 or more routines at meals, naptime, and bedtime. To promote development, showing books from infancy onward has been positively associated with subsequent language acquisition and school achievement.37,38 The 3 other parenting practices—talking to, playing with, and establishing predictable routines for infants—provide important opportunities to stimulate cognitive, social, physical, and emotional development.37,39
The presence of maternal depressive symptoms was measured in the 2- to 4-month interview using a modified version of the CES-D. The CES-D is a 20-item self-report scale designed to measure the frequency of depressive symptoms experienced in the previous week.40 Using the modified 14-item CES-D, scores of 11 or higher indicated the presence of maternal depressive symptoms; this value was calibrated against the cutoff of 16 used for the 20-item scale. Correlation of the reduced-item version with the full 20-item scale exceeded 0.95 in a sample of high-risk pregnant women.41 The α coefficient for the 14-item CES-D for Healthy Steps mothers was .85, similar to that for the total scale for the general population.40
We used χ2 statistics to compare parenting practices among mothers with and without depressive symptoms at 2 to 4 months post partum. Multiple logistic regression models were used to estimate the overall unadjusted and adjusted relations of the presence of maternal depressive symptoms with parenting practices. These models assessed whether differences by depressive symptoms were due to covariates that may potentially be associated with both depressive symptoms and parenting practices. These covariates were mother's age, race, ethnicity, marital or partner status, level of education, and employment status; whether she was a first-time mother; father's employment status; household income; whether the family owned their home; and child's age (Table 1).
In addition, because of a possible correlation of observations among families receiving pediatric care at the same site, multiple logistic regression analyses were also adjusted for the site of health care and enrollment in the Healthy Steps intervention group. Analyses were conducted using SAS statistical software, version 8.2 (SAS Institute Inc, Cary, NC).
The Committee on Human Subjects Research of the Johns Hopkins Bloomberg School of Public Health and the institutional review board of Columbia University College of Physicians and Surgeons granted study approval. For participants in this study, written informed consent was obtained at the time of enrollment, and oral consent was obtained before the 2- to 4-month interview.
A total of 5565 families completed enrollment forms; 4891 mothers (87.9%) completed the 2- to 4-month survey, and 4874 (87.6%) also provided depressive symptom data. When compared with nonresponders, mothers in the sample were more likely to be older than 20 years, white, non-Hispanic, married, and high school graduates and to report that the infant's father was employed.
Table 1 shows the percentage of women with depressive symptoms by demographic characteristics and the distribution of the demographic characteristics for the total sample. At 2 to 4 months post partum, 17.8% of mothers reported depressive symptoms. Mothers who were younger than 20 years, from a minority background, Hispanic, and not living with the biological father of the child, who had low incomes, and who had less than a high school education were more likely to report depressive symptoms than mothers without these characteristics (Table 1). Depressive symptoms were not associated with mothers being employed or parity.
Significantly fewer mothers with depressive symptoms than mothers without depressive symptoms lowered the temperature on water heaters (24.3% vs 31.0%) (Table 2). Comparable percentages used the wrong sleep position (14.3% vs 11.9%). The unadjusted odds ratios for lowering temperature on the water heater indicated decreased odds for mothers with depressive symptoms; however, it was not significant when adjusted for covariates (Table 3).
The frequencies of less-than-optimal newborn feeding practices at 2 to 4 months (giving cereal, water, or juice) differed between mothers with and without depressive symptoms, ranging from 11.9% to 40.0% in mothers without depressive symptoms and 16.8% to 50.5% in mothers with depressive symptoms (Table 2). Although the unadjusted regression model indicated that mothers with depressive symptoms had increased odds of engaging in these practices, the adjusted odds ratios for these variables were not significant (Table 3). Among mothers who had ever breastfed (76% for women without depressive symptoms and 71% for women with depressive symptoms), mothers with depressive symptoms had more than one-quarter reduced odds of continuing to breastfeed at 2 to 4 months compared with mothers without depressive symptoms (Tables 2 and 3).
Smaller percentages of mothers with depressive symptoms reported positive developmental parenting practices than mothers without symptoms; the odds of each practice also differed significantly in both the unadjusted and adjusted logistic regression models. Playing with the infant was the most frequent developmental practice, with 87.4% of mothers with depressive symptoms and 91.9% of mothers without depressive symptoms reporting they played with their infant at least once a day (Table 2). Frequencies of the 3 other developmental practices ranged from 28.2% to 66.9% in mothers without depressive symptoms and from 22.4% to 59.6% in mothers with depressive symptoms (Table 2). After adjusting for covariates, mothers with depressive symptoms had 19% reduced odds of showing a book to their infants at least once a day, one-quarter reduced odds of playing with their infant at least once a day and talking to their infants while working in the home, and one-third reduced odds of following 2 or more daily routines (Table 3).
The findings from this study provide a snapshot of early parenting practices among mothers with depressive symptoms in the critical first months post partum. Although we posited that there would be a significant relation between each of the parenting practices and the presence of maternal depressive symptoms, we found that the safety and feeding practices did not vary by depressive symptoms, after adjustment for covariates, with 1 exception. After controlling for covariates, we found that mothers with depressive symptoms had decreased odds of continuing breastfeeding. Our breastfeeding findings are different from those reported by Chung et al,5 who found no difference in breastfeeding duration for longer than 1 month. Their study used a smaller, community-based low-income sample, whereas this study used a larger, diverse national sample.
After adjusting for covariates, we also found that mothers with depressive symptoms had decreased odds of showing picture books, playing and talking with their infants, and following daily routines. These findings suggest that parenting practices that require more active interaction with infants, such as continuing breastfeeding and playing or talking with the infant, were reduced. Similar results have been found in direct-observation studies of mothers.13,16 As other experts have noted, the presence of elevated maternal depressive symptoms often results in the increased feelings of hopelessness and helplessness that can discourage mothers from engaging in parenting practices that have less concrete tangible outcomes.42
In this study, although depressive symptoms did not appear to influence several preventive parenting practices for mothers with newborns after adjustment for covariates, other studies2 with mothers of toddlers found differences in practices such as car seat use and covering electrical outlets. This may be due to the more demanding nature of parenting toddlers. In both studies, however, the presence of depressive symptoms resulted in reduced odds of mothers showing books or reading to their children on a daily basis, a parenting behavior that requires more sustained interaction from the mother.
Several limitations to this study should be noted. First, self-report measures of parenting may lead to overreporting of behaviors that are socially desirable among mothers who do not have depressive symptoms. In this study, which used a broad array of parenting practices, we have no evidence of overstating for mothers with or without depressive symptoms. Among mothers with depressive symptoms, the bias may be in the opposite direction, with the depressive symptoms leading to underestimates of actual parenting practices as a result of feelings of decreased self-efficacy about parenting ability.2 However, the review by Richters43 of 22 studies suggests that depressed mothers do not have distorted perceptions of their children. In addition, D'Souza-Vazirani et al44 found no difference in the validity of maternal report for children's short-term health care use based on the presence of maternal depressive symptoms. Our study findings suggest that it is possible to identify reduced positive parenting practices among mothers with depressive symptoms without having to use expensive direct-observation measures. Although a recent study45 suggests variability in the validity of self-reported home safety practices, lowering water temperature was among the more reliable measures and sleep position was not assessed.
Second, we used a self-report measure for depressive symptoms as opposed to a structured diagnostic instrument. Nevertheless, prior studies2 have found significant relationships between diminished parenting and self-reported depressive symptoms and suggest that the nondiagnostic CES-D may be more appropriate and preferable for pediatric practice and policy.
The findings from this study offer important implications for pediatric health care professionals and practice. The first is the need to screen for maternal depressive symptoms among all mothers during the postpartum period, when parenting practices are being established and when pediatric practices have frequent contact with families to provide guidance. Experts have stated that the scope of professional responsibility for pediatric physicians includes universal screening, guidance, and referrals for maternal depression.2,20,46,47 The US Preventive Services Task Force has recommended 2-item screeners by primary care professionals to detect depressive symptoms.48 A recent study49 in a busy urban pediatric practice found a significant increase in the detection of depressive symptoms among mothers during the first postpartum year following implementation of a universal postpartum depression screening during well-child care visits. Second, the challenge and opportunity for pediatricians when providing anticipatory guidance to mothers with depressive symptoms are to discuss the mother's engagement in parenting practices that require more ongoing interactions, such as continuing breastfeeding, playing, talking, providing routines, and showing books.
The results of this study add to the burgeoning evidence that highlights the importance of screening for maternal depressive symptoms in the postpartum period. Once depressive symptoms are identified, pediatric health care professionals have an important role in providing ongoing counseling and anticipatory guidance to enhance parental efficacy, as well as in referring mothers to appropriate health care professionals to assist with their depressive symptoms.4,50 To maximize pediatric physician interactions with mothers with depressive symptoms, further efforts are needed to ensure that linkages exist between adult and pediatric systems of care and that communities have adequate mental health resources. Such an approach has the potential to foster positive parenting, child health and development, and family well-being.
Correspondence: Cynthia S. Minkovitz, MD, MPP, Department of Population and Family Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, E4636, Baltimore, MD 21205 (email@example.com).
Accepted for Publication: October 21, 2005.
Author Contributions: Dr McLearn had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Funding/Support: This study received funding from The Commonwealth Fund, New York, NY.
Disclaimer: The views presented herein are those of the authors and not necessarily those of the funders, their directors, officers, or staff.
Previous Presentation: Presented at the Pediatric Academic Society Meeting; San Francisco, Calif; May 3, 2004.
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text:
Wright chases 2nd points title of season
Chad Wright captured his first career points championship last Friday night at Raceway 7. Now, he has a chance at a second title.
Wright, a Springboro native, heads into Eriez Speedway's final points event of the season Sunday night with a 29-point lead in the Bonnell's Collision Center Fastrak Late Models over Centerville's Max Blair, the division's defending champion. Their race to the finish headlines five championships that will be decided at the Greene Township dirt track. Wattsburg's John Phelps Jr. holds a 172-point lead in the Eric Walter Tree & Stump Removal Street Stocks over North East's Pat McGuire, who's vying for his third straight crown in the division.
Waterford's Steve Kania needs to erase Garland native Ryan Scott's 132-point lead to capture his second straight title in the Conway & O'Malley Limited Late Models.
Rich Michael Jr., of Ischua, N.Y., can continue an impressive 23-win season at regional dirt tracks with a title in the Plyler Overhead Door E-Mods. He enters the event with a 176-point lead over defending champion Joel Watson, of Conneaut, Ohio.
Kasey Hammond, of Stockton, N.Y., needs to simply start the feature to win back-to-back titles in the Kandy's Gentlemans Club Challengers. Hammond leads Erie's Joe Beach by 202 points.
Titusville's Robbie Blair clinched the Jay's Auto Wrecking Super Late Models title last weekend.
Meanwhile, at Lake Erie Speedway, Mill Village's Brandon DeBrakeleer has sliced Bliss, N.Y., native Jeremy Haudricourt's lead in Legends to 10 points. They have combined to win the past three championships in the class, with DeBrakeleer winning the past two seasons.
Erie's Matt Mead took a two-point lead over Corry's Donald Buell in Bandoleros with a feature win last Saturday.
North East's Randy Culver has a 13-point lead over Scott Wylie, of Blasdell, N.Y., in the Plyler Overhead Door Modifieds.
Dan Bittinger's quest for an undefeated season in Street Stocks ended last weekend with a runner-up finish. Yet he still has a 56-point lead over Jeff Breads, of Westfield, N.Y. Dave Krawczyk, of West Seneca, N.Y., leads Russ Conti, of Falconer, N.Y., by 98 points in Street Stocks.
Championship chase
Division leaders at area race tracks:
Eriez Speedway (Greene Township) -- 1 scheduled event left
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Division No. Name (hometown) Points Lead (runner-up)
Super Late Models WON11 Robbie Blair- (Titusville) 2,674 233 (Mike Knight, Ripley, N.Y.)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Fastrak Late Models 6 Chad Wright (Springboro) 2,320 29 (Max Blair, Centerville)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Limited Late Models 0 Ryan Scott (Garland) 2,819 131 (Steve Kania, Waterford)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173E-Mods 17x Rich Michael Jr. (Ischua, N.Y.) 2,524 176 (Joel Watson, Conneaut, Ohio)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Street Stocks 17P John Phelps Jr. (Wattsburg) 2,387 172 (Pat McGuire, North East)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Super Challengers 1 Kasey Hammond (Stockton, N.Y.) 2,546 202 (Joe Beach, Erie)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Lake Erie Speedway (Greenfield Township) -- 2 scheduled events left
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Division No. Name (hometown) Points Lead (runner-up)
Modifieds 24 Randy Culver (North East) 511 13 (Scott Wylie, Blasdell, N.Y.)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Street Stocks 11KDave Krawczyk (West Seneca, N.Y.)552 98 (Russ Conti, Falconer, N.Y.)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Legends 39 Jeremy Haudricourt (Bliss, N.Y.) 518 10 (Brandon DeBrakeleer, Mill Village)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Compacts 88 Dan Bittinger (Forestville, N.Y.) 563 56 (Jeff Breads, Westfield, N.Y.)
LeftAlign.53LeftAlign.76LeftAlign.153LeftAlign.173Bandoleros 24 Matt Mead (Erie) 508 2 (Donald Buell, Corry)
- Have clinched division championships
Note: Check out standings from all regional tracks at GoErie.com/racing.
Lernerville Speedway (Sarver) -- 1 scheduled event left
Division No. Name (hometown) Points Lead (runner-up)
Sprints 22 Brandon Spithaler (Evans City) 370 6 (Brandon Matus, Wampum)
Late Models 10 Alex Ferree, Saxonburg 401 51 (John Garvin Jr., Sarver
Modifieds 6w Matt Williamson (St. Catharines, Ontario) 442 50 (Brian Swartzlander, Leechburg)
Sportsman C33 Corey McPherson (Tarentum) 484 5 (A.J. Flick, Pittsburgh)
Little Valley Speedway (Little Valley, N.Y.) -- 1 scheduled events left
Division No. Name (hometown) Points Lead (runner-up)
Super Late Models No 7 Jason Dupont (Cyclone) 97 8 (Dutch Davies, Warren)
BRP 360 Late Models 3J Jeremy Wonderling (Scio, N.Y.) 114 10 (Bruce Miller, XXX)
E-Mods 68 Steve Dixon- (Smethport) 150 35 (Kyle Bedell, XXX)
Street Stocks 17X Andy Michael (Ischua, N.Y.) 1143 1 (Adam Aschcroft, Arcade, N.Y.)
# Doesn't include Thursday night's event
McKean County Raceway (Smethport) -- 1 scheduled event left
Division No. Name (hometown) Points Lead (runner-up)
Super Late Models WON11 Robbie Blair (Titusville) 405 20 (Jason Dupont, Cyclone)
RUSH Late Models 111Max Blair (Centerville) 466 89 (Adam Sixt, Sardinia, N.Y.)
E-Mods 1 Steve Dixon (Smethport) 387 32 (Vic Vena, Shinglehouse)
Street Stocks 6R Adam Ashcroft (Arcade, N.Y.) 509 61 (Brad Ullman, Allegany, N.Y.)
Mini Stocks 2b Joe Boylan (Lantz Corners) 407 33 (Mitch Boylan, Mt. Jewett)
Pure Stocks 21x Joe Layfield (Bolivar, N.Y.) 140 12 Roger Schweikart, N/A)
Mercer Raceway Park (Mercer) -- 1 scheduled event left
Division No. Name (hometown) Points Lead (runner-up)
410 Sprints 7 Eric Williams (Greenville) 1,116 2 (Jack Sodeman Jr., North Jackson, Ohio)
358 Modifieds 1G Frank Guidace (Mercer) 1,298 100 (Kyle Fink, Strattanville)
Outlaw Sprint Warriors 46 Michael Bauer (Clarion) 1,533 3 (Jim Morris, Fowler, Ohio)
Stock Cars 17M Rusty Moore (New Castle) 1,577 218 (Andy Thompson, Mercer)
Mini Stocks 44J Jamey Lee (Fairmont City) 1,571 269 (Pete Blazczak, Gibsonia)
Mod Lites 1 Shane Pfeuffer (Rochester, Pa.) 1,318 101 (Cody Bova, Struthers, Ohio)
Motordrome Speedway (Smithton) -- 1 scheduled event left
Division No. Name (hometown) Points Lead (runner-up)
Late Models 98 Neil Brown (Acme) 844 15 (Barry Awtey, Jenners)
Modifieds 97 George Nicola (Pittsburgh) 807 14 (Billy Hribar, Smithton)
Street Stocks 83 Matt Sever (West Newton) 842 4 (Shawn Phillips, Jefferson)
Chargers 15 Jonathan Hileman (Dawson) 764 11 (Zane Ferrell, Ruffs Dale)
Super Compacts 12 Greg Staggers (Waynesburg) 792 39 (Christopher Knight, Pittsburgh)
Raceway 7 (Conneaut, Ohio) -- 1 scheduled event left
Division No. Name (hometown) Points Lead (runner-up)
Fastrak Late Models 6 Chad Wright- (Springboro) 748 178 (Kyle Zimmerman, Albion)
E-Mods 92 Joel Watson- (Conneaut, Ohio) 711 96 (Mike Potosky, Guys Mills)
Street Stocks 21W Chris Withers- (Waterford)# 810 177 (Ed Bolyard, Geneva, Ohio)
Econo Mods 93 Brian Hathaway (Bristolville, Ohio) 593 81 (Chuck Steinle Jr., N/A)
Mini Stocks 9 Brad Cole (Erie) 730 45 (Bud Sergeff, Ashtabula, Ohio)
Sharon Speedway (Hartford, Ohio) -- 3 scheduled events left
Division No. Name (hometown) Points Lead (runner-up)
Big-Block Modifieds 31 Jim Weller Jr. (Hubbard, Ohio) 533 44 (Rex King Sr., Bristolville, Ohio)
RUSH Late Models 71L Dennis Lunger Jr. (Albion) 518 29 (Will Thomas III, Sharpsville)
Modifieds 3 Michael Kinney (Ashtabula, Ohio) 516 44 (Joe Gabrielson, Bristolville, Ohio)
Stock Cars 7 Michael Clark (Bristolville, Ohio) 516 60 (Tim Burns, Greenville)
Econo Mods 83 Jeremy Double (Bristolville, Ohio) 632 21 (Ryan Fraley, Wheatland)
Mini Stocks 27 Scott Gilliland (Warren, Ohio) 668 7 (Travis Creech, Niles, Ohio)
Stateline Speedway (Busti, N.Y.) -- Final
Division No. Name (hometown) Points Lead (runner-up)
Super Late Models 14B Dick Barton- (Ashville, N.Y.) 1,863 180 (Darrell Bossard, Centerville)
Crate Late Models 17 Damian Bidwell- (Eldred) 2,308 118 (Ryan Scott, Garland)
Limited Late Models 0 Ryan Scott- (Garland) 2,658 15 (Steve Kania, Waterford)
E-Mods 18 John Woodward Jr.- (Franklinville, N.Y.) 2,338 450 (Leonard Enos, Russell)
Street Stocks 24C Brian Crandall- (Stockton, N.Y.) 2,175 257 (Richard Wojtowicz, Limestone, N.Y.)
Super Sportsman 18 Jim Kibbe- (Clymer, N.Y.) 2,259 40 (Dan Nocero Jr., Jamestown, N.Y.)
Super Challengers 55K Casey Burch- (Kennedy, N.Y.) 2,464 390 (Travis Darling, Jamestown, N.Y.)
- Have clinched division championship


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2000 Chateau Beychevelle Saint-Julien
Producer: Chateau Beychevelle
Style: Red Wine
Grape Type: Bordeaux Blend
Origin: France
Region: Bordeaux
Appellation: Saint Julien
88 Points | Stephen Tanzer's IWC - May/June 2003
($40-$52) Good ruby-red. Exotic, highly aromatic nose features leather, cedar, roast coffee, minerals and chocolate. Smooth on entry, then a bit pinched in the mid-palate, with a faint peppery herbaceousness. Not overly tannic but seems a bit dry for a 2000.
91 Points | Robert Parker's The Wine Advocate
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Controversialist, born at Bergamo, 26 May, 1746; died near Milan, 24 June, 1813. He entered the Society of Jesus in 1763, and on its suppression was received into the Diocese of Bergamo, where he was shortly made a canon, and appointed archpriest and examiner of candidates for the priesthood. The zeal and ability with which he opposed the progress of Jansenism in Italy gained him a well-merited reputation, and Pius VI called him to Rome, where he became an Apostolic missionary. He was elected a member of the Accademia degli Arcadi (see ACADEMIES, ROMAN). In 1804 he hastened to rejoin the Society, which had been restored in Naples. Worn out at length by his charitable labours and penitential practices, he retired to the residence of Marquis Scotti near Milan, where he died. Among his important writings are: "Vera idea del Giansenismo" (1781); "Storia compendiosa della scisma della nuova chiesa d'Utrecht" (Ferrara, 1785); "Storia delle revoluzioni della Chiesa d'Utrecht" (Venice, 1787); "Compendio storico-cronologico...sopra il Baianismo, Giansenismo e Quesnellismo" (Foligno, 1792), all against Jansenism ; "Il falso discepolo di S. Agostino e di S. Tommaso" (Venice, 1779), a defence of Molinism. He translated from the English the Duke of Brunswick's "Fifty Reasons for preferring the Roman Catholic Religion" (Bassano, 1789); and from the French, "Les projets des incredules pour la ruine de la religion, dévoil;és dans les oeuvres de Frédéric, roi de Prusse" (Assisi, 1791).
The Catholic Encyclopedia is the most comprehensive resource on Catholic teaching, history, and information ever gathered in all of human history. This easy-to-search online version was originally printed between 1907 and 1912 in fifteen hard copy volumes.
Designed to present its readers with the full body of Catholic teaching, the Encyclopedia contains not only precise statements of what the Church has defined, but also an impartial record of different views of acknowledged authority on all disputed questions, national, political or factional. In the determination of the truth the most recent and acknowledged scientific methods are employed, and the results of the latest research in theology, philosophy, history, apologetics, archaeology, and other sciences are given careful consideration.
No one who is interested in human history, past and present, can ignore the Catholic Church, either as an institution which has been the central figure in the civilized world for nearly two thousand years, decisively affecting its destinies, religious, literary, scientific, social and political, or as an existing power whose influence and activity extend to every part of the globe. In the past century the Church has grown both extensively and intensively among English-speaking peoples. Their living interests demand that they should have the means of informing themselves about this vast institution, which, whether they are Catholics or not, affects their fortunes and their destiny.
Copyright © Catholic Encyclopedia. Robert Appleton Company New York, NY. Volume 1: 1907; Volume 2: 1907; Volume 3: 1908; Volume 4: 1908; Volume 5: 1909; Volume 6: 1909; Volume 7: 1910; Volume 8: 1910; Volume 9: 1910; Volume 10: 1911; Volume 11: - 1911; Volume 12: - 1911; Volume 13: - 1912; Volume 14: 1912; Volume 15: 1912
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*From Eli Lilly and Company (Drs. Yan, Helterbrand, and Wright), Lilly Research Laboratories, Indianapolis, IN; Pfizer Global Research & Development (Dr. Hartman), Ann Arbor, MI; and the Department of Pathology (Dr. Bernard), Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Correspondence to: S. Betty Yan, PhD, Eli Lilly and Company, Drop Code 0522, 307 E McCarty St, Indianapolis, IN 46285; e-mail: yan sau chi email@example.com
Study objective: To investigate whether protein C
levels predict 30-day mortality rate, shock status, duration of ICU
stay, and ventilator dependence in patients with sepsis.
Design: Retrospective analysis of a subset of a previously
published, prospective, randomized, double-blind, placebo-controlled
trial ("Effects of Ibuprofen on the Physiology and Survival of
Patients With Sepsis" [ISS]).
Setting: A
multicenter study performed in the United States and Canada (seven
Patients: Seventy hospitalized patients with
acute severe sepsis and failure in one or more organs at entry into the
ISS trial.
Measurements and Main Results: Blood
samples were obtained from all patients at baseline and at 20, 44, 72,
and 120 h after the initiation of study drug (ibuprofen or
placebo) infusion. Data obtained at these times included platelet
count, prothrombin time, and partial thromboplastin time. The results
described in this article are based on a subset of the total ISS
population for whom additional coagulation assays were performed on the
blood samples obtained at baseline and 44 h. These assays included
protein C antigen, D-dimer, and fibrinogen levels. A total of 63 of the
70 patients (90%) studied in this report had acquired protein C
deficiency at entry to the ISS trial (baseline). The presence and
severity of acquired protein C deficiency were associated with poor
clinical outcome, including lower survival rate, higher incidence of
shock, and fewer ICU-free and ventilator-free days.
Conclusions: Acquired protein C deficiency may be useful in
predicting clinical outcome in patients with sepsis. Clinical studies
are warranted to determine whether the replacement of protein C in
sepsis patients may improve outcome.
is associated with endothelial cell activation, a hemostatic profile
characterized by activation of the coagulation pathway, and subsequent
activation of the fibrinolytic system, which then is followed by the
inhibition of the fibrinolytic system.1–6 The resulting
procoagulant state may manifest clinically as a coagulation-dominant
disseminated intravascular coagulation (DIC) producing multiple organ
system failure.5–8
in the levels of various mediators of coagulation and fibrinolysis have
been reported to be associated with negative outcome in patients with
sepsis.9–10 Given its pivotal role in the coagulation and
fibrinolytic systems, protein C has been of particular interest as a
factor in the hemostatic abnormalities of patients with sepsis. Protein
C levels have been reported to be predictive of sepsis
outcome.4–5,7,11–13 The possible role of the protein C
pathway in sepsis has been reviewed extensively.14–15
The Ibuprofen in Sepsis Study (ISS) provided an opportunity to
assess data on hemostatic variables in severe sepsis in a large patient
population.16 We evaluated the association of protein C
levels and other hemostatic variables with clinical outcomes, including
mortality, in a subset of patients from the ISS.
The ISS was a randomized, double-blind, placebo-controlled
multicenter study of IV ibuprofen in 455 patients with severe sepsis.
The study was approved by the institutional review board at each of the
seven centers in the United States and Canada, and consent was obtained
from each patient or their next of kin. Patient characteristics and the
main study results have been reported elsewhere.16
Patients were enrolled into the study from October 1989 to March 1995.
Patients with a known or suspected site of serious infection had to
meet all of the following criteria: core temperature, ≥ 38.3°C or< 35.5°C; heart rate, ≥ 90 beats/min in the absence ofβ
-blocker treatment; and respiratory rate, ≥ 20 breaths/min (or
minute ventilation, > 10 L/min if the patient requires mechanical
ventilation). In addition, patients had to exhibit dysfunction of at
least one of the following organ systems: cardiovascular, renal,
ARDS/pulmonary, or CNS.
Investigational treatment consisted of IV ibuprofen (10 mg/kg q6h for
eight doses) or placebo given in a similar fashion. Patients were
observed for clinical outcomes, with 30-day all-cause mortality as the
primary outcome measure. Secondary measures included duration of ICU
stay, the presence or absence of mechanical ventilation, and the
presence or absence of septic shock. Secondary measures were described
in terms of ICU-free days, ventilator-free days, and shock-free days.
This methodology has been described previously.17 Organ
failure-free days were calculated over the 30-day study period. For
each patient, the number of organ failure-free days was calculated as
the number of days a patient was both alive and free of a particular
organ failure. Definitions of organ failure are shown in Table 1
.,17 The study did not demonstrate a statistically
significant effect of ibuprofen on ICU-free days, ventilator-free days,
shock-free days, or survival.16
All patients enrolled in the parent study had an APACHE (acute
physiology and chronic health evaluation) II score calculated at study
entry (average, 11 h from sepsis onset). Blood samples were
obtained from all patients at baseline and at 20, 44, 72, and 120
h after study entry. Data obtained at these times included platelet
count, prothrombin time (PT), and partial thromboplastin time (PTT).
The results described in this article are based on a subset of the
total ISS population for whom additional coagulation assays were
performed on the blood samples obtained at baseline and at 44 h.
The samples were taken as a subset of the database without regard to
the types of pathogen or any other etiology and included patients
treated with both placebo and ibuprofen. For the purpose of selecting
patients to be included in the coagulation analyses, patients were
categorized into one of the following eight groups based on these
measures: (1) abnormal PTT only; (2) abnormal PT only; (3) abnormal
platelets only; (4) abnormal PT and platelets; (5) abnormal PTT and
platelets; (6) abnormal PT and PTT; (7) PT, PTT, and platelets normal
("all normal"); and (8) PT, PTT, and platelets abnormal ("all
abnormal"). Abnormal values were defined as a platelet count of< 140,000/mL, PT ≥ 13.8 s, and PTT ≥ 39 s, which are values that
are generally consistent with normal range boundaries in local hospital
clinical laboratories. Ten patients from each of the groups except for
the all-abnormal group were selected randomly for inclusion in the
coagulation variable analysis. Only six patients in the parent study
exhibited abnormal values for all three measures; therefore, no patient
sample from this group (group 8) was included in this study. The
additional coagulation assays were for protein C antigen, D-dimer, and
fibrinogen levels. For the purpose of this analysis, normal ranges for
these coagulation variables were defined as follows: protein C antigen,
1.79 to 3.87 μg/mL18; D-dimer, 94 to 260 ng/mL; and
fibrinogen, 190 to 400 mg/dL.
Baseline and 44-h summary statistics are presented for each
coagulation measure (ie, levels of protein C antigen,
D-dimer, fibrinogen, and platelets) by 30-day all-cause mortality
status, which was the primary outcome measure for the ISS. To assess
the relationship between baseline and 44-h protein C levels and
mortality, threshold plots were constructed displaying mortality
incidence rates in subpopulations defined by baseline and 44-h protein
C antigen level thresholds. Logistic regression models were used to
assess the relationship of each coagulation measure with 30-day
all-cause mortality. A logistic regression model also was used to
assess the relationship of each coagulation measure to the presence or
absence of shock at baseline and at 44 h.
To assess the relationship between each coagulation measure and
ventilator-free days and ICU-free days, nonparametric Spearman rank
correlations were calculated and statistical tests for nonzero
correlation were performed. To assess correlations among coagulation
measures, nonparametric Spearman rank analyses also were conducted.
For all analyses, a two-sided p value of < 0.05 was considered to be
evidence of an association. Protein C levels measured at 44 h
after study entry were not available for three patients; their baseline
measurements were imputed for the logistic regressions, threshold
plots, and correlation analyses with ventilator-free days and ICU-free
days. Shock assessments measured at 44 h after study entry were
unavailable for nine patients. Because each of these patients was in
shock at baseline, and because shock status values after baseline were
available, it was assumed that all were in shock at 44 h after
study entry, and the last observed shock status value was used in the
last-observation-carried-forward imputation method for shock
status-related analyses.
Similar weighted analyses were performed with patient weighting based
on the proportion of patients in the ISS who fell into the same
subgroup as the analyzed patient. In general, the conclusions drawn
from the unweighted analyses and weighted analyses were consistent. The
conclusions from the unweighted analyses are presented below.
Table 2
displays baseline characteristics and results of the coagulation marker
levels (ie, D-dimer, fibrinogen, protein C antigen, and
platelets) of the seven subgroups of patients selected from the ISS
trial as defined in the "Material and Methods" section. A total of
58 of the 70 patients (83%) included in this study received placebo,
and the other 12 patients received ibuprofen in the ISS study. There
were no statistically significant (ie, p≤ 0.05)
differences between the two treatment groups with respect to platelet
levels, protein C levels, and fibrinogen levels at baseline and at
44 h after entry into the study. In addition, there were no
statistically significant differences between the two treatment groups
in ranked D-dimer levels at baseline and at 44 h.
Baseline protein C levels were below the lower limit of normal in
63 of the 70 patients (90%). A trend toward an increase in 30-day
mortality with lower baseline protein C levels was observed
(p = 0.19), and this same relationship was statistically significant
when 30-day mortality was compared with 44-h protein C levels
(p = 0.04) (Table 3
). Threshold plots describing the relationship between protein C antigen
levels at baseline and after 44 h and 30-day all-cause mortality
are displayed in Figure 1
. The thresholds were selected at 50%, 60%, 70%, 80%, 90%, and
100% of the lower limit of normal (ie, 1.79 μg/mL) of
protein C.
At both baseline (p = 0.01) and 44 h (p < 0.001), the
presence of shock was correlated with lower baseline protein C levels
(Table 4
). The threshold plots describing the relationship between protein C
antigen levels at baseline and 44 h and the presence or absence of
shock are displayed in Figure 2
A reduction in the number of ventilator-free days was associated with
lower protein C levels at both baseline (p = 0.02) and 44 h
(p = 0.03) (Table 5
). Fewer ICU-free days were associated with lower protein C levels at
both baseline (p = 0.04) and 44 h (p = 0.02) (Table 5).
Baseline D-dimer levels were above the upper limit of normal in
all patients. Thirty-six of the 70 patients (51%) had baseline
fibrinogen levels below the lower limit of normal. Forty-one of the 70
patients (59%) had baseline platelet levels below the lower limit of
normal. Based on a logistic regression model, lower baseline platelet
levels (p = 0.04) and 44-h fibrinogen levels (p = 0.02) were
associated with increased mortality (Table 3). Elevated levels of
D-dimer at 44 h were associated with increased mortality
(p = 0.02). Although baseline D-dimer levels were not significantly
associated with mortality based on the logistic regression model, this
finding was most likely due to the severe skewness in baseline D-dimer
measurements. When baseline D-dimer levels were replaced by their ranks
in the logistic model, the positive association between increased
D-dimer levels and increased mortality did reach statistical
significance (p = 0.02) (Table 3).
Increased baseline D-dimer levels (p = 0.02) and decreased baseline
fibrinogen levels (p = 0.03) were associated with the presence of
shock at baseline (Table 4). Lower platelet levels at baseline were
associated with fewer ICU-free days (p = 0.047) (Table 5). Higher
D-dimer levels were associated with fewer ICU-free and ventilator-free
days; however, significance was achieved only when 44-h levels were
compared with ventilator-free days (p = 0.03) (Table 5). No
association was demonstrated between fibrinogen levels and ICU-free or
ventilator-free days.
The correlation between the coagulation markers and protein C
levels was weak or nonexistent (Table 6
). The sole significant positive correlation observed was between the
44-h platelet levels and protein C antigen levels (p = 0.03). A trend
toward a positive association between 44-h fibrinogen levels and
protein C antigen levels also was observed (p = 0.07). At baseline,
there was also little correlation among PT, PTT, and platelet levels,
and protein C levels, especially in the subgroup of patients that had
normal baseline PT, PTT, and platelet levels (Table 2). The mean
protein C levels in this subgroup was 1.26 μg/mL. A total of 9 of the
10 patients in this subgroup had baseline protein C levels below the
lower limit of normal.
Activated protein C is a serine protease that inhibits coagulation
factors Va and VIIIa, subsequently blocking the generation of thrombin.
Both plasminogen activator inhibitor (PAI)-1 and activated
thrombin-activatable fibrinolysis inhibitor (TAFI) are inhibitors of
the endogenous fibrinolytic system. TAFI is activated by thrombin.
Activated protein C also exhibits profibrinolytic activity by
neutralizing PAI-1 or by limiting the activation of TAFI by limiting
thrombin generation.19–20 Protein C circulates largely in
the zymogen form in plasma and is activated via the complexing of
thrombin with the endothelial cell surface protein
thrombomodulin.21 In large blood vessels, the activation
of protein C to activated protein C is facilitated by the endothelial
protein C receptor in complex with
thrombin-thrombomodulin.14,22In this study, we measured
and analyzed four hemostatic markers (protein C, D-dimer, fibrinogen,
and platelets) in a randomly selected subset of patients (n = 70)
from the ISS trial. All ISS patients met the currently accepted
definitions of severe sepsis at study baseline.23 A total
of 63 of the 70 patients (90%) studied in this report had protein C
levels at baseline below the lower limit of normal. Thus, our study
data suggest that almost all patients with severe sepsis, as selected
using standard criteria,23 had acquired protein C
deficiency. The threshold plots (Fig 1, 2) indicate that the lower the
protein C levels, the higher the mortality and the higher the
occurrence of shock. Protein C levels are lower in patients with
sepsis, presumably as a result of associated consumptive
coagulopathy,,4–5,7,12–13,24–25 although decreased
production also may play a role. Diagnostic kits are readily available
to measure plasma protein C levels, and only citrated plasma samples
are required. Thus, studies of protein C levels in many pathologic
states, including sepsis, have been published in the literature.
However, in order to measure plasma activated protein C levels, a
special blood collection tube containing benzamidine, in addition to
citrate, is required.26 So, samples for measuring levels
of activated protein C levels have to be prospectively collected. In
addition, to our knowledge, no diagnostic kit for measuring activated
protein C is commercially available, and the methodology is
complex.26As such, the authors are only aware of a single
published article with data on the levels of activated protein C in
patients with sepsis.27 The data in that article indicated
that only about 20% of patients with sepsis have elevated activated
protein C levels beyond the normal range of 1 to 2 ng/mL to about 5 to
20 ng/mL. The increase in activated protein C in those 20% of patients
appeared to be sporadic with no discernible pattern. The relationship
between the protein C levels and the activated protein C levels in
patients with sepsis is complex and not well understood, and it
requires many more studies.
Findings from this study of the association of protein C levels with
mortality and the presence of shock in severe sepsis patients are
consistent with those reported by others. Hesselvik et
al12 reported that patients with septic shock had lower
protein C levels than those without shock on the day following initial
hospitalization. Fourrier et al7 found that initial
protein C levels were significantly lower in nonsurviving sepsis
patients with DIC and documented a significant correlation between
protein C levels in nonsurvivors. In a subgroup with sequential
measurements, nonsurvivors exhibited a persistent deficiency in protein
C activity. Lorente et al5 measured coagulation and
fibrinolysis variables in sepsis patients on days 1, 4, and 7 after
hospital admission. Their analysis showed that the median protein C
level in nonsurvivors was below the lower limit of normal on day 1
after hospital admission. There was no significant difference between
survivors and nonsurvivors in protein C measurements at the time of
hospital admission. However, serial protein C measurements on
subsequent days after hospital admission showed a significant
difference between survivors and nonsurvivors. Only survivors exhibited
a progressive normalization of protein C levels. The data from our
study further support the suggestion from Lorente et al5
and others28 that serial protein C measurements provide
better prognostic value than a single measurement in monitoring
patients with sepsis. Recent data from Boldt et al25 also
suggest that serial protein C measurements may be a helpful molecular
marker to differentiate severe sepsis from other causes of critical
Among the four hemostatic markers studied in this report, protein
C levels correlated best with the major outcome measures of severe
sepsis (ie, mortality, presence of shock, ICU stay, and
ventilator dependence). Fibrinogen level was not as consistently
associated with the outcome measures, probably because it is known to
be an acute-phase reactant.29 The fibrinogen level goes up
in the early phase of severe infection, and fibrinogen subsequently is
consumed during the severe coagulopathy phase of severe sepsis. In
patients with sepsis, fibrinogen has been reported to be higher in
nonsurvivors than survivors,5 lower in nonsurvivors than
in survivors,13,30–32 or not significantly different
between survivors and nonsurvivors.2,33 Perhaps the
seemingly contradictory data on fibrinogen levels in patients with
sepsis are due to differences in sampling time and the acute-phase
reactant nature of fibrinogen. Protein C level also was reported by
others5,34to be better associated with sepsis outcome
than D-dimer levels or platelet levels. Thrombocytosis rather than
thrombocytopenia has been observed in some sepsis
patients.35 It is also interesting to point out that in
this study, 9 of the 10 patients in the subgroup who had normal
baseline values for PT, PTT, and platelets had baseline protein C
levels below the lower limit of normal. These data suggest that protein
C may be an earlier and more sensitive marker than the more global
coagulation markers of PT, PTT, and platelets that are currently more
widely used in hospitals. The data from this and other
studies5,7,24–25,35 suggest that protein C measurement, in
addition to the DIC panel of markers, may offer a better prognostic
value in sepsis.
The importance of the protein C pathway in sepsis has been highlighted
by findings in animal models. In Escherichia coli-induced
septicemia in baboons, antibody blockade of the protein C pathway
markedly increased the severity of endotoxin doses at concentrations
for both the lethal dose in all exposed subjects and at 10% of the
lethal dose.36 Our data reinforce the findings of other
clinical and animal investigations that have indicated that endogenous
protein C plays an important role in sepsis-associated coagulopathy.
Other than the well-known antithrombotic activity of the protein C
pathway, there is also evidence that protein C exerts direct
anti-inflammatory effects apart from those mediated by thrombin
inhibition. These may include the reduction of endotoxin-induced
cytokine production by monocytes and activated protein C-endothelial
protein C receptor interaction with activated
neutrophils.15,37–39 PAI-1, an inhibitor for
fibrinolysis, also is found to be elevated in sepsis and is positively
correlated to mortality in most reported studies.20
Because activated protein C has profibrinolytic activity by
neutralizing PAI-1, other investigators5,7,40–41 have
suggested the need for randomized, controlled trials of activated
protein C in patients with sepsis. Our finding that 90% of patients
with severe sepsis have protein C levels less than the lower limit of
normal gives further support to this notion. As such, a recombinant
form of human activated protein C has been developed and is undergoing
clinical study.
In patients with severe sepsis, the mechanism for activating protein C
in vivo (protein C converting to activated protein C by
thrombin in a complex with thrombomodulin) may be operating
suboptimally.42Indeed, the most recent data from patients
with sepsis support this hypothesis.43Thus
activated protein C would be expected to exert a more potent
and predictable effect than protein C, the zymogen form. Activated
protein C also may be more resistant to neutrophil elastase than is the
zymogen form.44
In summary, we have found that lower protein C levels are common in
patients with sepsis and are associated with several severely negative
clinical outcomes, including increased mortality and occurrence of
shock, as well as increased duration of mechanical ventilation and ICU
stay. These findings suggest that protein C levels can be used
prognostically and that such agents as protein C, or preferably,
activated protein C, may reverse the acquired protein C deficiency in
patients with sepsis and improve outcome. A large, placebo-controlled,
phase III trial using recombinant human activated protein C in patients
with severe sepsis has been undertaken to test whether this
experimental drug can improve the 28-day all-cause mortality rate of
this disease.
Abbreviations: APACHE = acute physiology
and chronic health evaluation; DIC = disseminated intravascular
coagulation; ISS = Ibuprofen in Sepsis Study; PAI = plasminogen
activator inhibitor; PT = prothrombin time; PTT = partial
thromboplastin time; TAFI = thrombin-activatable fibrinolysis
Drs. Yan, Helterbrand, and Wright are employees of Eli Lilly and
Company. Dr. Hartman was an employee of Lilly during the collaboration
of this study. This study is a scientific collaboration between Lilly
and Dr. Bernard.
Funds needed for conducting the coagulation assays at the
University of Vermont were provided by Eli Lilly and Co. The ibuprofen
clinical trial was supported by grant HL43167 from National Heart,
Lung, and Blood Institute of the National Institutes of Health.
Adapted from Bernard et al.16
Fio2 = fraction of inspired oxygen
Thousands of platelets per cubic microliter.
Values given as mean (SD).
IQR = interquartile range (25th percentile
to 75th percentile of distribution).
Includes imputation of baseline protein C antigen
levels for three patients.
See Table 3 for abbreviations not used in the
Includes imputation of baseline protein C
antigen levels for three patients.
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Saturday, June 30, 2007
Review: Ratatouille
Here's a question for the mini-masses that might come through: is there anyone in the world making better family movies--animated or otherwise--than Pixar? I honestly don't think so.
Pixar has found a magic formula for family films, and Ratatouille continues their tradition of excellence. Pixar has figured out that movies for kids don't need to be so dumbed down that adults don't enjoy the show. They understand that "for kids" doesn't mean automatic potty humor. Most important, they understand that there has to be a sense of wonder and magic that is only brought out with exquisite art direction, superb storytelling, and characters that, while perhaps not quite complex, have enough depth to be compelling.
The most natural comparisons for Ratatouille are to other Pixar movies, so here is the quick rundown before talking specifics. Ratatouille isn't as funny as Finding Nemo or as action packed as The Incredibles, but it is as heartwarming as Toy Story and more satisfying than Monsters, Inc. Last year's Cars was a solid entry in the catalog, but Ratatouille is something closer to to a classic.
The story, about a rat who wants to be a cook, is far better developed and more involving than I had expected. Forgive me for doubting directory Brad Bird or The Incredibles and The Iron Giant--the man has a wonderful touch with light drama and sense of comedy that most Hollywood directors could only wish for. His consistency is astonishing.
Another thing that Pixar does is cast great voice talent. From Ellen DeGeneres hilariously loopy turn as an absent minded fish in Finding Nemo to Dave Foley's ant with grand plans in A Bug's Life, Pixar chooses the right voices to fill their casts. Patton Oswalt, as our hero Remy, strikes the right tone of an eager young man (ahem, "rat") without ever becoming irritatingly earnest. The casting coup, though, is putting Peter O'Toole's voice to the character of critic Anton Ego. Not only is Ego rendered perfectly, but O'Toole's voice gives him a brooding presence and flavor that makes him one of the more memorable characters in any recent animated feature.
The artwork on the movie is breathtaking. The views of Paris--at times misty and dark or gorgeously lit at night--raise the art of animation another notch. While I hadn't thought that an animated could be better than the underwater scenes of Finding Nemo, but there were moments in Ratatouille that the scenery looked as real and as solid as any photograph. Little touches and details abound (take a look at Anton Ego's typewriter) that keep the scenery not only lovely but constantly interesting. The animators employed by Pixar are, like the rest of the crew, simply brilliant. These men and women are artists.
Ratatouile is a wonder--it's family friendly entertainment that hasn't been watered down for the kids, that's safe for most families (I noticed one--arguable--profanity and there are a few tense moments early on when Remy and the rest of the rats are chased from an old woman's country home), and that has a great message for anyone who pays a little attention. While it drags just a bit in the third act, and isn't quite as funny as some of Pixar's other films, it's message, acting, and astonishing beauty make it well worth the price of a ticket.
And Peter O'Toole's big moment, with a commentary about critics, is simply perfect.
Page 1 of 1 pages
© 2005 by the authors of ResurrectionSong. All rights reserved.
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Search by Company
Use the list below to find a company that you would like to work for. What you're going to find when you click on the letter is a set of companies in alphabetical order. These companies won't be in particular industries, but rather in an order from top to bottom.
When you click on the page, you'll be able to find the following information about each and every company that is listed below:
History of the company: Find out what the company is all about. Find out when the company was founded, who the founder is and what they stand for. This will give you a rather good vibe on what the company is all about, as well as the atmosphere when working here.
The positions available: Each and every company is going to have different positions, as well as wages available. It's always best to know about what you're going to get paid, as well as what kind of job openings that are available. Larger companies are going to have hundreds of job descriptions, while smaller companies may only have a handful.
The benefits: Benefits are what draw good employees into a company. Without many benefits, employees may not work with the company. Most of the larger employers offer perks such as discounts, health insurance, vision, 401k, retirement packages and many more.
How to apply to the company: Each and every company is going to be different when it comes down to the application process. Some companies are going to require that you fill out a paper application, while some companies may allow you to apply online only. This section will be able to tell you exactly how to apply for the job, as well as a link that you can use to apply directly.


text:
Hi how thicken border 1-pixel wide with 2 pixels with matlab? thanks
I=imread('image.jpg'); edg = edge(I,'log',0);
doc imdilate
thank you, I tried it but I haven't got a good result. There is another solution please
That's the way to do it. Why was your result not good? Can you upload some example images illustrating why it's no good? What will you end up doing with this thickened image anyway?
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text:
Microsoft as a company has done a huge amount for the IT industry. As a teenager, my 2nd generation entry into the computer world (the first was a BBC Micro) was an Elonex 386 running Windows 3.1, and 23 years later I'm typing this on a laptop with Windows 7. However, this continuity has in part been due to the company's dominance within the desktop PC operating system marketing, a dominance achieved – allegedly [Ed-nicely vague!] – by anticompetitive and monopolistic behaviour. Without raking up past legal battles between Microsoft and others my main irritation with the company is how this style of behaviour affects its web browser, Internet Explorer (IE).
Standards, what standards?
Go back a few years and Internet Explorer was the browser used by over 50% of internet users. Corporate IT departments put Windows on the desktops and with the upgrade cycle traditionally slower in these environments, a B2B website had to be tested back to Internet Explorer 6, a browser first released in 2001 with Windows XP. Now, our testing just goes back to IE7 which is only six years old.
- Inconsistent support for the latest versions of cascading style sheets (CSS)
- Different handling of padding and margin CSS elements to the standards
- Inconsistent behaviour when "floating" elements as part of styling
- Poor support for transparent images in earlier versions of IE
- Deviation between versions of IE – i.e. a layout that works in IE6, will cease to look the same in IE7
One of the main things holding back IE and its support of features is the dogmatic view that browser release should be a version defined iterative process, IE6, IE7, IE8, IE9, IE10. These new releases often take years to be released and are often tied into an operating system release: for example Windows XP does not support IE9+; IE10 will be unsupported in anything but Windows 7+; and this goes directly in opposition to the fast pace at which new web technologies are introduced and adopted. This often leaves users lagging behind other browsers which take a more flexible and proactive stance on feature support and updates, updating their browsers automatically with new features without packaging them into a definitive product release. In contrast, Firefox has moved away from this philosophy and a recent series of releases went from version 4 to 10 in under a year.
What does this mean for web developers?
The code below will be no stranger to web developers everywhere.
Essentially, it is a series of if/then statements to display different stylesheets for different versions of Internet Explorer – either an attempt to get the same look and feel working across the browser versions, or a pattern of graceful degradation where the developer has perhaps accepted that those lovely rounded corners using CSS3 are never going to work in IE7 alongside the gradient background, so the older version will see a slightly different look and feel. For example, square corners and the gradient or vice-versa.
What does this mean for our clients?
As we progress along our web projects – with beautiful standards-compliant code, we apply browser compatibility testing. As our handcrafted site is displayed on Internet Explorer, even with an IE vs non-IE approach from the outset, we can guarantee there will be at least some "fixes" to do. A good analogy is going from looking in a mirror in your bathroom to a hall of mirrors in a circus tent – some have minor distortions but others do horribly nasty things to your appearance. The added time and therefore cost of IE compatibility has even made one Australian retailer, Kogan, attempt to charge more for web visitors using IE based on the amount of development centre around "just getting it to work in IE".
As an agency, Marketecture accept this as part of our development process and don't charge additional fees like Kogan, but we raise the IE issues today [Ed-we're not just ranting then?!] for the following reasons:
- To help raise awareness of why, in the final testing stages, layout bugs crop up
- To further introduce the concept of graceful degradation – the design you have approved as a client will be built but how it is displayed in different browsers will differ due to their individual constraints
What does the future hold?
Even Microsoft are trying to kill off IE6, but realistically, this issue will continue to act as a bugbear in the development team. We eagerly await IE10 and all the "surprises" that will bring although when we're all using tablets based on Google Android or Apple iOS, that might be better as Google are good with standards and Apple only hate Flash animation!


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2. "The Talented Mr. Ripley," $9.8 million.
3. "The Green Mile," $9.7 million.
4. "Any Given Sunday," $9 million.
5. "Galaxy Quest," $8.3 million.
6. "Toy Story 2," $7.5 million.
7. "Magnolia," $6.6 million.
8. "Bicentennial Man," $5.2 million.
9. "Deuce Bigalow: Male Gigolo," $5 million.
10. "Snow Falling on Cedars," $4 million.
Mice at the Movies
"Stuart Little," starring E.B. White's charming white rodent, grossed $11.5 million since Friday and remained the top weekend movie for the second week running, and "Fantasia/2000," featuring Mickey Mouse, posted elephantine numbers in limited release, according to industry estimates. "Fantasia," playing in only 54 IMAX theaters in North America, boasted a phenomenal per-theater average of $50,000 (that's compared with $3,860 for "Stuart Little," playing on 2,979 screens). Elsewhere in the weekend rat race:


text:
item(s) in cart
My Account X
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Product DescriptionThe Gander Mountain Waterfowl Equipment Line is forged from years of diverse hunting experience. Our advanced materials, construction, and technology combine to create superior gear that won't let you down. These versatile and generously sized bags are great for carrying your gear to all your adventures. Bags offer large capacity main compartments, multiple additional pockets and organizer options, a super-duty padded shoulder strap, and a non-slip bottom. All bags are made of durable, waterproof material with a heavy-duty oxford poly shell and sport Advantage Max-4 camouflage.
Front flap pocket with interior organization and quick magnetic closure. End zippered pockets. Molded bottom compartment with zippered access provides protection and stability. Multiple interior accessory pockets and zippered vinyl pockets. Front D-rings to easily attach game carriers. 18" x 13" x 12".


text:
-- NLB Poster at the International Myeloma Workshop Represents a Major Advance in Nursing Care --
North Hollywood, CA, and Kos, Greece, July 2, 2007 -- The Nurse Leadership Board (NLB), of the International Myeloma Foundation (IMF) presented a poster entitled "Nurse Guidelines for Enhanced Patient Care," at the 11th International Myeloma Workshop, a meeting involving more than 1600 people this past week in Greece. The guidelines represent specific protocols and procedures nurses can use to help myeloma patients optimize their treatments, manage side effects and receive the support they need. The Nurse Leadership Board is a unique partnership between the IMF and 20 oncology nurses from leading centers treating myeloma in the United States. It provides an opportunity for nurses from these cancer centers to share their expertise with colleagues in community based settings who may see few myeloma cases each year.
"We believe this presentation represents a groundbreaking opportunity for these nurses at a major medical meeting, validating the valuable services the NLB provides," said Susie Novis, president and co-founder of the IMF. "Myeloma patients and their families face unique challenges during the course of their treatment. The NLB guidelines provide nurses with the specific information they need to support their patients during these critical periods in their care."
Myeloma, also called multiple myeloma, the second most common of the blood cancers, is a cancer in the bone marrow affecting production of red cells, white cells and stem cells. In their presentation, the nurses addressed complications that may be associated with the "novel" myeloma treatments - newer regimens that help extend the lives of patients, but which may be accompanied by their own unique set of side effects including the risk of blood clots, gastrointestinal problems, and peripheral nerve damage (neuropathy).
The presentation notes that when they occur, these adverse effects may decrease patients' willingness to continue with the treatment as prescribed. The guidelines are intended to provide strategies to help increase patient compliance that in turn may help patients realize the full benefits of their therapies and improve their quality of life.
"Healthcare is a team effort," said Kena Miller, R.N. "Physicians make the decisions, but nurses implement the treatment and help manage the patients' response to their care."
"We get to know these patients well, and understand what they may be facing, even when they may not know what to ask on their own," said Deborah Doss, R.N. "That means when patients say 'oh, my feet are cold,' I know they could have peripheral neuropathy, nerve damage, a concept that may not be familiar to most patients."
The poster presentation details each area covered by the NLB guidelines. The guidelines themselves are being prepared for journal publications.
ABOUT THE INTERNATIONAL MYELOMA FOUNDATION The International Myeloma Foundation is the oldest and largest myeloma organization, reaching more than 135,000 members in 113 countries worldwide. A 501 (c) 3 non-profit organization dedicated to improving the quality of life of myeloma patients and their families, the IMF focuses in four key areas: research, education, support and advocacy. To date, the IMF has conducted more than 120 educational seminars worldwide, maintains world-renowned hotline, and operates Bank On A Cure®, a unique gene bank to advance myeloma research. The IMF can be reached at (800) 452-CURE or www.myeloma.org, and in Spanish at www.myelomala.org.


text:
A driver was charged after a woman was fatally struck by a car at Northwoods Mall Tuesday morning.
The woman, who has not been identified by authorities, was leaving the Belk department store when she was hit by a car in the crosswalk around 11 a.m., according to North Charleston police.
Raymond R. Clement, 32, of Aiken Street in Charleston, was charged with reckless homicide, according to police spokesman Spencer Pryor. He is being held in the Charleston County jail.
Send us your news tips, photos and videos by email to email@example.com or call (843) 937-5581.


text:
Anyone like to suggest untranslated works of spiritual value to modern Christians?
Someone has written to me, mentioning a translator who has done a couple of English translations of "spiritual classic"-type patristic works, and is open to translating more. The results will be sold, unfortunately.
What should I suggest to them? That has not been translated before?


text:
Nayeli is such a fagsauce.... I cant even stand it!
by Thee Princess Amy October 10, 2011
Trending Now
Can you define these popular missing words?
Top Definition
A slang term for the spooge of a homosexual man.
adam spooged his fag sauce all over steve
by jacob mitsubishi January 06, 2009
Fagsauce is a word to descibe someone who is very, very gay. People like Zeffie and Ksharp, and Zeffie and Ksharp together. Also describes semen from a gay mans penis. Sick.
Ksharp: Yeah me and Zeffie were having teh buttsecks with each other all night.
Zeffie: He got fagsauce all over me.
Zeffie: He got fagsauce all over me.
by Better then Zeffie November 19, 2004


text:
My husband and I are moving in three weeks... Should I list our new address for shipping and billing?
Printable View
My husband and I are moving in three weeks... Should I list our new address for shipping and billing?
Hmmm. That's tough. I don't have a solid ship date, but it's looking like we'll be shipping 2 weeks from now. You can always call my office - 888-774-6259 - to change your address or to find out more as we approach the ship date and your move.
Thanks for purchasing my new book!
Hmm, it says I will get free shipping if I am one of the first 1000 pre-orders, which I assume, I will be if I order it within the next few minutes.
But I don't live in the US and when it comes to chosing a shipping option I can only go with priority mail, which is an additional 12,95$.
So, do I have to pay that extra money or not?
I'm curious about that as well as I live in Canada and while it isn't the normally the same rate to ship to Canada, there is normally international shipping... Actually... I'll just get it shipped to our US post office box! Thanks
The new site looks great! And - I just pre-ordered 4 copies of the book (will give out to friends and relatives to introduce them to the Primal lifestyle).
Did encounter a wee bit of head-scratching on the order form... I'm in Calgary, Canada and I ticked the box to ship to same address as the billing address - but - when I looked at my email copy of my receipt, it indicates country "US" (for shipping), while my billing info was country "Canada". (I assume it will make sense that shipping is, in fact, to Canada, not US.)
Congratulations on the publishing of the book - looking forward to reading it.
I pre-ordered the book and I'm really keen to get started on reading it. I've had a huge lifestyle change this last year with P90X....I'm now hoping to take that to another level by going Primal!
- Jude
Stupid stuff!
I don't have a credit card (credit cards are not something usual in most parts of Europe anyways) and my brothers credit card somehow didn't get accepted.
I'm not gonna order the book now. There are no alternative paying options and if I really had to pay shipping as well, almost 40$ for one single book is just ridiculous, tell me what you want.
I know that it's probably a very good book and I would LOVE reading it, but right now, there's now way I'm gonna pay that much and get into all that credit card trouble.
Hey Mark,
I am very excited about the book. One note though the website does a goofy thing where you don't know that you ordered the book because the page just resets. I ended up ordering two books, which is fine I guess. (The extra one will make a good gift.) You may want to have you people check into it though.
Best of luck.
I was pleasantly surprised at the price especially after seeing what some folks want for an e-book. Jumped right on it!
Matthias...sure hope something can be worked out for you. There has to be a cheaper method of getting the book to you.
Hi Mark,
Ordered the book yesterday. As I am in Edinburgh Scotland I assume that's why I had to pay the shipping. Anyway, good luck with the book, I know it will be excellent.