text:
Nicchi Scans
Tuesday, July 28, 2015
Nicchi Scans is back!
I've realized now is a good time to get back into scanlating for a number of reasons. The main one being that obtaining raws is insanely cheap and easy now that you can get Kindle versions of volumes and magazines. I also need to keep myself sharp since I'm translating articles for a otaku news site now. Releases for this will be erratic since Necro and I will be chipping away at it whenever we have time. If we finish this first volume before the second is released then we'll just wait because it's probably not far off now.
All in all, I'm excited to get back into this and have a pile of stuff I want to translate. Keep an eye on this blog for all sorts of releases.
Posted by Raiken at 3:54 AM 4 comments:
Labels: manga
Thursday, March 27, 2014
My drive to return to scanlating is definitely coming back. I just need to ride out the last four months of my ALT job and then I can start devoting more time to it.
Posted by Raiken at 11:00 PM 2 comments:
Monday, November 11, 2013
Oh hey...
It hadn't occurred to me until I discussed it with a friend, but I realized that I'm burned out on Japan. Nowadays I watch American TV shows and spend a lot of my free time watching crap online that usually has nothing to do with Japan. I still like anime and manga, but I've realized that I hardly ever look at it these days. I did see the new Madoka film in theaters recently and loved it. When I do finally go home, I'll probably become obsessed with it all again, but right now it just doesn't seem to interest me.
This is my second time living in Japan(my first being a a study abroad for a year). With an awesome salary I've managed to see pretty much the entire country over the course of these past two years. I improved my Japanese a lot, and I've done pretty much everything else I wanted to do here. Most importantly, starting my career as a professional translator. I've gotten all kinds of cool shit and had some awesome cultural experiences, but ultimately being around Japanese people and even some of the non-Japanese is exhausting. I'm counting the days, but I'll still enjoy my final year here as best as I can.
Posted by Raiken at 8:32 AM No comments:
Wednesday, February 6, 2013
Posted by Raiken at 7:54 AM 1 comment:
Sunday, October 28, 2012
No I'm not dead. Although I wouldn't blame you guys if you thought that. I got distracted by various things and then got sick which delayed things even further. I did manage to finish Yellow Pop finally. You can get the final chapter at Conan's website.
I've decided to not do Stu-Hiro's new series Bakamatsu Alien. Quite frankly, after having read a few chapters of it, I've come to the conclusion that it's not very good :/ Nicchi-scans did well when it first started out by focusing on only one project anyway. NTT will be the only series I will work on. I will still occasionally do some other stuff like doujinshi or chapters out of a compilation I like. Any of the other stuff I talked about doing earlier has been put on the back burner for now. Tomorrow the site will be getting a cleanup of the links section. Hopefully I'll get around to actually doing the first chapter of NTT soon since it's been a year almost since I first announced the project.
Posted by Raiken at 8:14 AM 1 comment:
Wednesday, July 18, 2012
Still not dead Part 3
Posted by Raiken at 11:29 AM 3 comments:
Labels: manga
Friday, June 8, 2012
Still not dead Part 2
My how time flies. I was checking Stu-hiro's blog today, only to discover that's he's just started his latest work! It's a samurai manga called Bakamatsu Alien. I've got a copy of the raw coming in the mail soon but I haven't discussed doing the series with Conan yet. The first chapter is a whopping 60 pages.
Here's a breakdown of our current status:
Yellow Pop: Only one chapter left, but I keep getting distracted by random crap. I have some free time this weekend, so I'm considering finally finishing it. Obviously though, I say a lot of things that don't always happen :P
Negative Twin Towers: I have all of the latest raws including some very nice tank scans thanks to Conan. It's basically been put on hold this whole time because we were planning on finishing Yellow Pop first but obviously that's taken much longer than we wanted.
Otaku no Musume-san: I have everything I need save for the omake pages from the final volume(I can't seem to find a raw of it anywhere). This is pretty low on my priority list though since we still haven't even started NTT yet, and the arrival of Stu-Hiro's newest series is pretty big news.
Other: There are 4 more random dojin I translated a long time ago but haven't had them edited yet. Conan and I are planning on releasing them some time after Yellow Pop is finished. Otaku no Triangle is probably next on my list in regards to doujinshi I want to translate. I have many others I want to do, but right now doujinshi in general is probably a ways off since I really need to start working on our regular projects.
Posted by Raiken at 9:33 AM 2 comments:
Subscribe to: Posts (Atom)


text:
Under CELCP legislation "the state lead agency will be responsible for: soliciting projects that are consistent with priorities outlined in the state's plan, reviewing them for completeness, prioritizing them according to state criteria, and nominating projects to the national selection process." Eligible proposals have to be either located in the coastal zone, which includes the 17 New Hampshire towns nearest to the coast, or the coastal watershed, which encompasses 42 New Hampshire towns.
The CELCP competition only takes place if federal funding is allocated to the program. When the competition runs, NHCP solicits and ranks proposals using the CELCP criteria and ranking system, taking into careful consideration the projects' ability to compete nationally. The CELCP goals and project criteria can be found in detail at the NOAA CELCP Web site. Then, NHCP staff hosts a public meeting to discuss the ranking and reach final consensus before sending proposals to the National Oceanic Atmospheric Administration (NOAA).
Under the program, each of the 34 states with coastal management programs can participate. In addition, the CELCP process requires states to develop a CELCP plan in order to be eligible to nominate projects. The Land Conservation Plan for New Hampshire's Coastal Watersheds was initiated by the Coastal Program and Piscataqua Region Estuaries Partnership to help fulfill that requirement, and has since served as the foundation of the state's CELCP plan. The Society for the Protection of N.H. Forests, The Nature Conservancy, and the Strafford and Rockingham regional planning commissions were all major players in the development of that plan. The New Hampshire CELCP Plan identified priority areas for CELCP funding within the coastal watershed and has been approved by NOAA.
CELCP History
In 2002, Senator Judd Gregg, in coordination with state and federal land conservation experts, established CELCP "for the purpose of protecting important coastal and estuarine areas that have significant conservation, recreation, ecological, historical, or aesthetic values, or that are threatened by conversion from their natural or recreational state to other uses," giving priority to lands that can be effectively managed and protected and that have significant ecological value.
Prior to 2006, CELCP funds were exclusively allocated through the congressional appropriations process. However, the 2006 appropriations bill called for NOAA to create a national priority list for CELCP appropriations. The last CELCP competition was for the FY2012 funding cycle.
A New Hampshire proposal ranked Number 1 nationally in the 2006 competition. A partnership of organizations, including the Trust for Public Land, Bear-Paw Regional Greenways, and the town of Strafford worked together to conserve five properties in Strafford. The focal point of the initiative, a 287-acre parcel containing approximately 1.5 miles of frontage on the Isinglass River, was purchased with the help of a $1.3 million grant from the CELCP.

subset: commoncrawl


text:
Utah Jazz (14-13, 3-8 road) vs. OKC Thunder (21-6, 9-1 home)
TV: FS OK (Cox 37, HD 722, Tulsa Cox 27, DirectTV 679, UVerse 754)
Stream: Click here
Radio: WWLS The Sports Animal (98.1 FM, 640 AM, 97.1 FM Tulsa)
Time: 7:00 CT
Offensive Rating: Thunder – 107.8 (4th), Jazz– 104.4 (10th)
Defensive Rating: Thunder – 102.8 (15th), Jazz – 105.0 (20th)
Pace: Thunder – 93.5 (4th), Jazz – 90.9 (18th)
View from the enemy: Salt City Hoops
Is it just me or does it feel like the Thunder just played this team? The thing about that win in Utah on Friday was that the Thunder seemed to sort of cruise to a win. It wasn't really easy necessarily, but it didn't look like OKC had to work for it. The Thunder caught a break as Paul Millsap didn't play that well and the Jazz couldn't get to the free throw line.
Utah is finishing up its back-to-back-to-back though tonight and coming off an ugly loss to the Hornets. They've dropped five of seven and desperately need a good win tonight to get back in the conversation of being taken seriously. So I'd expect a good shot from the Jazz in this one.
Utah coming in: The Jazz lost last night to New Orleans and have dropped five of seven.
Three Big Things
1. Defending the paint. I don't know if it was Serge Ibaka's work on him or if it was just a bad night, but beating the Jazz starts with limiting Millsap. Both on the glass and in the paint. Between Al Jefferson and Millsap, the Jazz want to beat you with easy baskets inside. The more they get, the worse it gets.
2. Turnovers. It's still an issue, and still something the Thunder have to do better with.
3. KD against Gordon Hayward. It's the biggest edge OKC has. Hayward just has no chance of guarding Durant. Whether in the post, off the dribble or in transition, the ball needs to find KD's hands as much as possible. Durant didn't have to do much in Friday's game because Russell Westbrook took care of it, but if things get tight, Durant should take over.
Tip at 7:00 CT. Go Team OKC.


text:
Al Aqsa Center says that Israel will create a Jewish section of Al Aqsa, similar to Hevron's Cave of Patriarchs.
Arutz Sheva:
By Gil Ronen
The Al Aqsa Center has released a statement saying that it has received information that Israel plans to divide up the Temple Mount into separate Jewish and Muslim sections, in the same way that the Cave of the Patriarchs in Hevron is divided.
According to the statement, as reported by the Elder of Zion blog, Jews would then be able to perform "Talmudic rituals" (i.e., pray) in the sacred site.
The Al Aqsa report goes on to say that Israeli police plan to use the new arrangement to cleanse the Temple Mount of Muslims under flimsy pretexts.
According to another plan "revealed" by the Al Aqsa Center, Jews will freely enter the mosque between 8 a.m. and 11 a.m., between Muslim prayer times. These alleged plans will be implemented this year.
Dozens of Arab stoned Christian tourists and police on the Temple Mount Sunday morning, a day after a former Muslim Mufti warned of a possible "break-in" by Jews. Read more
Categories: Asia, Israel, Middle East, Muslim Heritage


text:
New Products
Ksenia Kimono£120.00
Hollyhood Dawn£115.00Out of stock
Hollyhood Kitty Candy£95.00
Hollyhood Alex
Our best-selling hooded scarf! This luxurious and ultra warm hood is the perfect style ally for him and her. Crafted in a distinctive Black Stuart Tartan and fully lined in our latest love a new and extra thick black faux fur this hood keeps you protected and warm when it's chilly outside. Wrap the scarf around your neck and snuggle in or take it up a notch and style with a belt over your coat to create that coveted hourglass silhouette. This oversized hood is exactly what you need to give your favourite coat that extra kick.
Shop This Hollyhood on the online shop →
Testimonials view all →
Never in my life, have I fallen so in love with one piece, of course I love my bags and shoes - but this hood, is somewhat special. These pieces are made with love and positivity, made to make you feel good when you're wearing them. Lucy, blogger floralsandcorals.com


text:
The reason GOMAD works so well is that the carb to protein ratio combined with the workout is very anabolic. The reason GOMAD gets you fat is because the carb to fat ratiio is very fattening in the context of so many calories. I think with the cream idea you will really only be getting fat from all the extra calories.
I will second Leangains as the best way to put on LBM while keeping the fat off or maybe even losing BF.


text:
Top Definition
A male characterised by an almost compulsive desire to quote Arnold Schwarzenegger lines or make groaning noises in the style of the Austrian bodybuilder. Clapinsons are also known to quote lines from the popular British comedy 'Extras' such as "is he having a laff?"
That guy is a total Clapinson.
by MC91342 December 27, 2009
Trending Now
Can you define these popular missing words?


text:
Thank you for visiting our past auction result archives. If you have an item identical (or similar) to this auction lot, please call, write or contact us to discuss. We will be able to help you.
Lot # 801 (of 1525) < Previous Lot | Next Lot >
Hank Aaron Signed 20th Home Run Game Ball From 1957 Season
Starting Bid - $1,000.00, Sold For - $2,900.00
PLEASE NOTE: Robert Edward Auctions has determined that the authenticity of this lot is extremely questionable. We believe this item is a fraud and we have cancelled the sale of this lot. The Aaron signature is authentic, but we do not believe that this is a genuine Hank Aaron home run ball. We also believe that the accompanying letter from Donald Davidson's step-daughter is a fabrication. Many similar balls have been sold in many other auctions over the past several years. The widespread acceptance of these "Hank Aaron home run baseballs" in the marketplace caused us to let our guard down on this item when preparing this catalog. We apologize for any inconvenience.
Presented is the actual baseball that Hank Aaron hit for the 20th home run of his M.V.P. 1957 season off of Dodgers' pitcher Don Newcombe. This was only the 86th home run of career. Of course, 1957 was also the year in which Aaron led the Braves to the world's championship. This is one of the few documented Hank Aaron home run baseballs in existence, originating directly from Milwaukee Braves director of public relations and traveling secretary Donald Davidson. The "home run baseball" is the most coveted of all baseball game souvenirs. Most home run baseballs disappear into obscurity the moment they are taken home after a game. The fate of most remains a mystery, and those actually saved almost always inevitably lose their identity over time. Here is, without question, an actual home run ball hit by the all-time Home Run King. It was retrieved and kept by Braves longtime traveling secretary Don Davidson, who has written on the ball on a side panel in his hand the following identification: "Henry Aaron's 20th Home Run vs. Dodgers June 26, 1957 Pitcher Don Newcombe." The ink notations are bold ("10"). The ball exhibits general wear from game-use. The ball remained with Davidson until his death in 1990. It is accompanied by a letter on Braves' stationery signed by Davidson's step-daughter attesting to the ball's origin and chain of custody, which reads in part, "My step-father, Donald Davidson, was the director of public relations and traveling secretary for the Milwaukee Braves. He secured this baseball that Hank Aaron hit for his 86th career homerun. He then wrote the information regarding the homerun on the ball. It has been in his collection until his death in 1990 and in my possession until now. This ball is a 100% authentic game used baseball hit by Hank Aaron for his 86th career homerun." The ball was recently signed by Aaron ("9") on the sweet spot, and is also accompanied by a copy of the box score of the game which shows that Newcombe's catcher was Roy Campanella, who therefore would have also had to have handled this ball. "Hammerin' Hank" hit 755 homers in his career, but few well documented home run balls from his career exist. This is one of the very few. LOAs from Mike Gutierrez/GAI and James Spence & Steve Grad/PSA DNA. Reserve $1,000. Estimate $2,000/$3,000. SOLD FOR $2,900.00
(Click the smaller thumbnails to the left and right (if any) to cycle through each photo in the gallery of images for this lot.)


text:
The Athlete Machine - Red Bull Kluge
You could describe Red Bull Kluge very simply as a machine. But there is nothing simple about Red Bull Kluge. Among its parts are 11 world-class athletes, a crew of 100 people, three half-pipes, a skateboard, an off-road truck, a dirt bike and a helicopter. Courtesy of Red Bull


text:
Francais »
S.T. Specialty Foods manufactures and markets private label and store branded dry dinners, which include macaroni and cheese dinners, add-meat skillet dinners, rice dinners, and meatless side dishes. S.T. sells products to leading food retailers and wholesalers, and has leveraged its leadership in private label macaroni and cheese into a rapidly growing position in the dry-dinner category.


text:
Heading Home
Trip Start Apr 27, 2012
11Trip End May 06, 2012
Map your own trip!
Loading Map
Loading Map
Map Options
Show trip route
Hide lines
After a very scenic round about route through Manhattan, many roads were blocked due to a charity bike race, we arrived at JFK 15 minutes before our departure! We had been driving around for 2 hours! We tried to check in for the flight but it had already boarded and the door was closed to the plane. We had missed it by several minutes!!! So frustrating.
We sat down to wait for the next flight which would be in 3 1/2 hours. We checked our email, made some calls, had some lunch and watched the next flight board and fly away. It was oversold and had no room for us. We went back to our computers and waited for the next flight. Finally, at 7pm we boarded the last flight of the day and headed home. The flight touched down in Salt Lake City and we arrived home just before midnight. What a long day! So glad to be home.


text:
Broncos beat reporter Mike Klis previewed questions surrounding the Denver Broncos, Sanchez versus Lynch and Von Miller's big contract.
Mike Klis previewed Broncos training camp & a new era at QB
Darren Smith - Interviews
Recently in Darren Smith - Interviews
Mike Pereira on unsportsmanlike conduct penalties & backstory of Hochuli's Chargers gaffe
Fox NFL rules analyst Mike Pereira on how referees are calling unsportsmanlike conduct penalties, his book "After Further Review" and the backstory of Ed Hochuli's infamous Chargers Broncos call from 2008. Download Subscribe: iTunes | Stitcher |
Herm Edwards "They don't know how to finish"
NFL analyst Herm Edwards on another Chargers loss, if offensive coaches make better head coaches than defensive coaches & why the Saints are as injury plagued as the Chargers. Download Subscribe: iTunes | Stitcher | Google PlayComments
Rocky Long on if it's a "revenge game" vs South Alabama & feeding Pumphrey the football
Aztecs head coach Rocky Long on preparing for South Alabama after a bye week, if there's pressure to feed Donnel Pumphrey the football Download Subscribe: iTunes | Stitcher | Google PlayComments comments
Dave Roberts on winning West & overcoming obstacles
Dodgers manager Dave Roberts on winning the NL West, overcoming a myriad of injuries throughout the year, setting up his postseason pitching & a special Vin Scully celebration. Download Subscribe: iTunes | Stitcher | Google PlayComments comments
Major Garrett on Chargers culture of losing & historic presidential debate
CBS Chief White House Correspondent Major Garrett on why the Chargers have created a culture of losing, why it's a disconnected fan base and getting ready to cover an unprecedented presidential debate. Download Subscribe: iTunes | Stitcher


text:
161 cameras are up all over Lancaster, but the city doesn't pay for them. They belong to the Lancaster Community Safety Coalition, a non-profit organization. News 8's Katelyn Smith explains how one of them could belong to you. Click here to find out more.
How can you adopt-a-camera in Lancaster city?
Published On: May 07 2013 07:52:04 PM EDT
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


text:
Single Article Purchase:
Computed Tomography in the Diagnosis of Osteoid Osteoma in Infancy
BUSUTTIL A, FLETA J, SARRÍA A, et al.
Am J Dis Child. 1989;143(9):1000-1000.
Published online September 1, 1989
Choose criteria for pricing info
Want online access for an institution? Learn More/Request Quote >
Obtain AMA PRA Category 1 Credit™ by reading an article and completing an online quiz. Quizzes are available to AMA Members, subscribers, and those who have purchased tokens.


text:
The experimental work involved in this report is the result of an attempt to determine the comparative nutritive efficiency of milk heated to different temperatures. There is considerable evidence in the literature to the effect that scurvy among infants may be caused by feeding cooked milk exclusively; in fact, this notion is so prevalent that many pediatrists still insist on giving raw cow's milk, notwithstanding that the hygienic conditions of this may be far from desirable. It is only in our larger cities that certified milk may be obtained, and even here the price makes it prohibitive for the great majority of homes.
In order to meet present conditions and to make milk more nearly safe for infant feeding, the practice of pasteurizing or boiling has been resorted to. Pediatrists differ as to the relative value of these two processes. The European pediatrists1 report excellent results with boiled milk—the
Thank you for submitting a comment on this article. It will be reviewed by JAMA Pediatrics editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers' bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Need assistance?
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.


text:
If you missed part one, here's an infographic showing every England kit from 1872 to 1982, as designed by our friends at Printsome.
Part two is now with us, taking the story from there to modern day and England's attire for the forthcoming 2014 World Cup.
All of these shirts have a story. Who could forget the Italia 90 design, or the Euro 96 shirt?


text:
Why is nitrogen essential to the growth of a fungus, but not to the spread of rust?
A fungus is a living organism, while rust is not
What can you infer from the fact that nitrogen gas is useless to animals?
Animal cells can only use nitrogen when its combined with other elements
What conclusion can you draw from the fact that sewage adds compounds to the environment?
Animals get rid of nitrogen compounds in their waste
What describes the path of a nitrogen molecule through the environment?
It moves through the environment repeatedly, but not in the same order


text:
10 vehicles matched;
Now showing page 1 of 1. 25 results per page.
Listed by Private Seller
350 4bll with air, new duel exhaust with flow master mufflers, new tires, comple new brake system, new alternator and
Listed by Dusty Old Cars
Call our sales team for more information about this car at (603) 818-8511 We take over 300+ pictures of each car
Listed by North Shore Classics
1972 Buick GS Stage 1 CloneFresh 455 V-8 Engine400 Automatic TransmissionNew Posi Rear End 373 gear ratioPower Steering Power Brakes
Listed by Fast Lane Classic Cars Inc.
This 1972 Buick Skylark Suncoupe has a 350 C.I. V8 w/ 4BBL Carb, TH350 Automatic Transmission (Numbers Matching), Very Rare
Listed by Gateway Classic Cars
For sale in our Houston showroom is a built and bad to the bone 1972 Buick Skylark GS. 0-100 REAL
Listed by Arizona Classic Car Specialties
Listed by Gateway Classic Cars
For sale in our St. Louis showroom is a very well built, Pro-Touring 1972 Buick Skylark. The odometer reads 36,450,
Listed by Cruisers Specialty Autos
Beautiful 1972 Buick Skylark convertible ready for your top-down enjoyment. This Skylark appears to be all original except for
Listed by Okoboji Classic Cars LLC .
This Buick GS survives as an excellent example of the breed. The 455 runs as good as the rest
Listed by Midwest Muscle Cars
1972 buick sun coupe nice clean driver quality car paint is good, interior is good rare sun coupe option motor is heathy runs and


text:
Registration is now open for free youth day programs taking place this summer at the Owl Brook Hunter Education Center in Holderness. These programs give youth (boys and girls) age 10-15 the chance to learn about the shooting sports, bowhunting and other outdoor skills. Sessions will be offered in July and August at Owl Brook, which is operated by the New Hampshire Fish and Game Department.
Pre-registration is required and will be conducted on a first-come, first-served basis. Space is limited -- enrollment is limited to 20 youth per day -- so please register early. To register, call 603-536-3954. There is no charge for the sessions. Each program is hands-on, and all participants will be encouraged to be involved.
Day programs will be held on Tuesdays and Thursdays, unless otherwise noted, beginning July 10 and ending August 9. Tuesdays will be for youth age 10-12 and Thursdays will be for youth age 13-15. In addition, a girls-only shooting sports day will be offered on Wednesday, August 8, for girls age 10-15.
Another popular offering is a dual Hunter Education Certification week that will take place on August 14, 15, 16 and 17, during which students have the opportunity to earn both their Hunter Education and Bowhunter Education certifications. Youth ages 12-15 who attend and meet all requirements will receive their Hunter Education and Bowhunter Education Certification card.
Check out the action by viewing a three-minute video about the youth day programs at Owl Brook at www.huntnh.com/Hunting/hunter_ed_center.htm [2].
Participants may register for one or more sessions, which are held from 9:00 a.m. to 3:00 p.m. on the dates listed below. Bring your own bag lunch.
Week 1:
Bowhunting/Archery skills
Tuesday, July 10 - (10-12 year olds)
Thursday, July 12 - (13-15 year olds)
Week 2:
Outdoor Skills
Tuesday, July 17 - (10-12 year olds)
Thursday, July 19 - (13-15 year olds)
Week 3:
NH Furbearers
Tuesday, July 31 - (10-12 year olds)
Wednesday, August 1 - (13-15 year olds)
Week 4:
Shooting Sports
Tuesday, August 7 - (ages 10-12)
Wednesday, August 8 - Girls only (ages 10-15)
Thursday, August 9 - (ages 13-15)
Week 5:
Hunter and Bowhunter Education Week
(Certifications issued upon successful completion of week)
August 14, 15, 16, 17 (4-day program -- ages 12-15)
"New Hampshire is still a relatively rural state, but fewer youth are taking advantage of outdoor opportunities," said Tom Flynn, Program manager at Owl Brook. "The Owl Brook Hunter Education Center is here to inspire young people to become involved in the outdoors. These free, skill-based summer workshops are a fun way to help them discover what it's all about."
The mission of the Owl Brook Hunter Education Center is to educate individuals in the knowledge, skills, and behaviors needed to become safe and responsible hunters, trappers and stewards of the state's natural resources. Its facilities include shooting ranges, classroom space and interpretive trails. To learn more about Owl Brook, please visit www.wildnh.com/Hunting/hunter_ed_center.htm [3]. [4]
Activities at the Owl Brook Hunter Education Center are made possible by Federal Aid in Wildlife Restoration [4]funds.
The New Hampshire Fish and Game Department is the guardian of the state's fish, wildlife and marine resources and their habitats. Visit www.huntnh.com [5].
[1] http://www.addtoany.com/share_save?linkurl=http%3A%2F%2Fwww.biggamehunt.net%2Fnews%2Fsign-now-summer-youth-programs-owl-brook-hunter-education-center-new-hampshire&linkname=Sign%20Up%20Now%20for%20Summer%20Youth%20Programs%20at%20Owl%20Brook%20Hunter%20Education%20Center%2C%20New%20Hampshire%20%7C%20Big%20Game%20Hunt
[2] http://www.huntnh.com/Hunting/hunter_ed_center.htm
[3] http://www.wildnh.com/Hunting/hunter_ed_center.htm
[4] http://www.wildlife.state.nh.us/SFWR_program/sfwr_program.htm
[5] http://www.huntnh.com/
[6] http://www.biggamehunt.net/sections/New_Hampshire
[7] http://www.biggamehunt.net/sections/Youth_Hunting


text:
- 2 total posts
- 2 reviews
Reviews by VGHouston
I love the results - Botox - Houston, TX
I will never go to anyone else but Dr. Siegel! he is gentle, and accurate! He knows what he's doing. I am a regular at his office every six months when i have to get the botox touched up. I love the results, and its very natural looking! There is NO wait time either! The botox procedure is... READ MORE
I Will Only Let Dr. Siegel Do my Injections - Houston, TX
You go into the office and there is NO wait! If there is its about 5 min. I get botox and fillers from Dr. Siegel. He makes sure that you are numb and there is little to no pain! I don't ever swell up to much. You can go during lunch its that fast! I also love thats his goal is to look natural !... READ MORE


text:
You are here Biopharmaceutical
Glossary homepage/Search
> Informatics > Pharmaceutical Cheminformatics
Cheminformatics/ Chemoinformatics
Glossary & taxonomy
Evolving terminologies for emerging
Comments? Questions? Revisions? Mary Chitty email@example.com
Last revised
December 12, 2014
View a Printer-Friendly
Version of this Web Page!
Informatics Term index: Finding guide to terms in these glossaries
Related glossaries include
Applications Drug
Discovery & Development
Chemistry: Assays
& screening Chemistry
libraries & synthesis
Algorithms & data
analysis, Bioinformatics,
& Software, Drug
discovery informatics Information management &
3D-QSAR Three-Dimensional Quantitative Structure-Activity Relationships:
Involves the analysis of the quantitative relationship between the
biological activity of a set of compounds and their three- dimensional properties
using statistical correlation methods. IUPAC Computational Broader terms: QSAR;
SAR Structure Activity
Relationship Cheminformatics
Narrower term: CoMFA
Comparative Molecular Field Analysis Related term: drug design
ab initio:
From the Latin: from the beginning. In modeling seems
to refer to models devised without experimental data.
ab initio
Quantum chemical calculations
using exact equations with no approximations which involve the whole
electronic population of the molecule. [IUPAC Computational]
ab initio
molecular dynamics:
The Parrinello group has applied ab initio Molecular Dynamics
(MD) in which all forces were computed quantum- chemically to chemical reactions
in general and to biological systems in particular, with results that compared
favorably with experiment and older force field methods. The ab initio
method was found to be of ``useful accuracy'' for simulations of biomolecules
... With a 1000 times faster computer (relative
to 32 processors on a Cray T3E) the dynamics of a quantum- chemical system
consisting of up to 10 atoms could be simulated for 10 s. [Opportunities in Molecular Biomedicine in the Era of Teraflop
Computing: Report on a Meeting Held March 3 & 4, 1999 in Rockville,
MD, Organized by the NIH Resource for Macromolecular Modeling and Bioinformatics
Beckman Institute for Advanced Science and Technology, University of Illinois
at Urbana- Champaign
artificial neural nets: Algorithms simulating the functioning
of human neurons and may be used for pattern recognition problems,
e.g., to establish quantitative structure- activity relationships. IUPAC
Computational Broader term neural nets; Related
terms: drug design
chemical informatics:
Chemical informatics is the application of computer technology
to chemistry in all of its manifestations. Much of the current use of
cheminformatics techniques is in the drug industry, but chemical informatics is
now being applied to problems across the full range of chemistry. Chemical
informaticians often work with massive amounts of data. They construct
information systems that help chemists make sense of the data, attempting to
predict the properties of chemical substances from a sample of data, much as
Mendeleev did many years ago when he accurately predicted the existence and
properties of unknown elements in the periodic table. Thus, through the
application of information technology, chemical informatics helps chemists
organize and analyze known scientific data and extract new information from
that data to assist in the development of novel compounds, materials, and
processes. Chemical Informatics at Indiana University, 2007 http://www.chembiogrid.org/related/resources/ciatiu.html
informatics and cyberinfrastructure collaboratory at Indiana University
chemical information:
Many people view chemoinformatics as an
extension of chemical information, which is a well established concept covering
many areas that employ chemical structures, data storage and computational
methods, such as compound registration databases, on- line chemical literature, SAR
analysis and molecule- property calculation. Timothy Ritchie
"Chemoinformatics; manipulating chemical information to facilitate
decision- making in drug discovery" Drug Discovery Today 6(16): 813-814,
Aug. 2001
chemical information system:
include registration, computed and measured properties, chemical descriptors
and inventory. The primary purpose is to be able to identify a chemical
substance, find compounds similar to the target compound and determine
the location of the compound. To effectively build it, an object definition
of the chemical sample is paramount…The hub [central database] of the chemical
information system is the inventory system. Frank Brown "Chemoinformatics:
What is it and How does it Impact Drug Discovery" Annual Reports in Medicinal
Chemistry 33: 375-384, 1998
See definition in IUPAC
Biomolecular Screening
Partnerships and
collaborations to further drug discovery, open source chemistry, recent advances
in cheminformatics, modeling for safety, using biological and chemical
information to guide hit-to-lead phase and lead optimization, and repurposing
drugs by applying 21st century tools to find new targets. BioIT
World Track 5 Cheminformatics April 2010 Boston MA
order CD
The practice of finding the
"best- fitting" compounds to address particular targets. The field
encompasses diversity analysis and library design, virtual screening,
drug design, and tools and approaches for predicting activity and other
properties from structure.
by the numbers in Google.com cheminformatics seems to
be the currently most used form of this word, overtaking chemoinformatics. See the Glossary
FAQ question #3 for details and methodology. Related terms:
discovery & development, Drug
discovery informatics
What is cheminformatics? eMolecules http://www.emolecules.com/doc/cheminformatics-101.php
See also chemoinformatics
Hawkins DM, Basak SC, Kraker J, Geiss KT, Witzmann FA, Combining
Chemodescriptors and Biodescriptors in Quantitative Structure-Activity
Relationship Modeling, J Chem Inf Model. 46(1): 9-16, Jan 23, 2006
The focus [of chemoinformatics] is placed on four traditional
research areas: chemical database systems, computer-assisted structure
elucidation systems, computer-assisted synthesis design systems, and 3D
structure builders. WL Chen, Chemoinformatics:
past, present, and future. Journal of Chemical Information Model, 46(6):
2230-2255, Nov 2006
Chemoinformatics is an integral part of the discipline of knowledge
management. Nicholas J. Hrib, Norton P. Peet "Chemoinformatics: are we
exploiting these new science?" Drug Discovery Today 5 (11): 483- 485, Nov.
Increasingly incorporates "compound registration
into databases, including library enumeration; access to primary and secondary
scientific literature; QSAR Quantitative Structure Activity Relationships)
and similar tools for relating activity to structure; physical and chemical
property calculations; chemical structure and property databases, chemical
library design and analysis; structure- based design and statistical methods.
Because these techniques have traditionally been considered the realms
of scientists from different disciplines, differences in computer systems
and terminology provide a barrier to effective communication. This is probably
the single most challenging problem that chemoinformatics must solve. M
Hann and R Green "Chemoinformatics – a new name for an old problem?" Current
Opinion in Chemical Biology 3:379- 383, 1999
An emerging area, which annotates small
molecules and also libraries with structure – function, synthesis, and all
other relevant data used to design and develop better drugs. "Combinatorial
Chemistry" Nature Biotechnology 18: Supplement Oct. 2000, from Nature
Biotechnology 16, 691– 693, 1998
Mixing of information technology and management
to transform data into information and information into knowledge for the
intended purpose of making better decisions faster in the arena of drug
lead identification and optimization. ..In Chemoinformatics there are really
only two [primary] questions: 1.) what to test next and 2.) what to make
next. The main processes within drug discovery are lead identification,
where a lead is something that has activity in the low micromolar range,
and lead optimization, which is the process of transforming
a lead into a drug candidate. Frank Brown "Chemoinformatics: What
is it and How does it Impact Drug Discovery" Annual Reports in Medicinal
Chemistry 33: 375-384, 1998 Related terms:
chemi-informatics, chemometrics, computational chemistry.
The application of
statistics to the analysis of chemical data (from organic, analytical or
medicinal chemistry) and design of chemical experiments and simulations. IUPAC
The science of relating measurements made on a chemical system
or process to the state of the system via application of mathematical or
statistical methods. International Society of Chemometrics "ISC symbol and
definition of chemometrics" 1997 Wikipedia chemometrics http://en.wikipedia.org/wiki/Chemometrics
Related terms:
discovery informatics 3D-QSAR, comparative molecular field analysis
ClogP values
ClogP values:
Calculated 1-octanol/ water partition coefficients,
frequently used in Structure-Property Correlation (SPC)
quantitative structure-activity relationship (QSAR) studies
(Leo, 1993). IUPAC Computational
Logarithm of the partition coefficient.
CML Chemical Markup Language:
Wikipedia http://en.wikipedia.org/wiki/Chemical_Markup_Language
Comparative Molecular Field Analysis CoMFA:
method that uses statistical correlation techniques for the analysis of the
quantitative relationship between the biological activity of a set of compounds
with a specified alignment, and their three-dimensional electronic and steric
properties. Other properties such as hydrophobicity and hydrogen bonding can
also be incorporated into the analysis. (See also Three-dimensional
Quantitative Structure-Activity Relationship [3D-QSAR]). IUPAC
Medicinal Chemistry
Uses statistical correlation techniques for the analysis of the quantitative
relationship between the biological activity of a set of compounds with
a specified alignment, and their three- dimensional electronic and steric
properties. Other properties, such as hydrophobicity and H-bonding
can also be incorporated into the analysis (Cramer et al., 1988; Kubinyi,
1993b). IUPAC Computational Narrower term: topomeric CoMFA
computational drug
design: It is 13 years since the publication of Glossary of Terms Used in
Computational Drug Design. In this period the subject has undergone considerable
change particularly because the new high throughput technologies and the
genomics revolution have fuelled a need for novel computational methods to
handle the resulting data deluge. In addition, simple computational tools are
now available for use by medicinal chemists. The glossary will provide
intellectual support for conversations between laboratory and computational
chemists and for the interpretation of calculations that a bench chemist or
student might perform.... it will add hundreds of new terms that describe
methods used in virtual screening, data mining, and cheminformatics. For example,
there will be an entry for the IUPAC InChI textual definition of a molecular
structure, for ROC curves that describe the simulated ability of a virtual
screening method to retrieve actives from a database that includes many
inactives, and for recursive partitioning that attempts to define the
combination of molecular properties that distinguish active from inactive
molecules. IUPAC Computation Drug Design
Glossary update, 2011 http://www.iupac.org/web/ins/2010-057-3-700
Computer-Assisted Molecular Design CAMD:
Involves all computer-assisted
techniques used to discover, design and optimize compounds with desired
structure and properties. IUPAC Computational
Computer-Assisted molecular modeling
CAMM: The investigation
of molecular structures and properties using computational chemistry and
graphical visualization techniques. IUPAC Computational
computational chemistry: A discipline
using mathematical methods for the calculation of molecular properties
or for the simulation of molecular behavior. It also includes, e.g.,
synthesis planning, database searching, combinatorial library manipulation
(Hopfinger, 1981; Ugi et al., 1990). IUPAC Computational
chemistry seeks to predict quantitatively molecular and biomolecular
structures, properties, and reactivity by computational methods alone. It uses
modern chemical theory to predict the speed of unknown reactions and the
synthetic sequences by which complex new molecules can be made most
efficiently. Computational chemistry allows chemists to explore how things
work at the atomic and molecular levels and to draw conclusions that are
impossible to reach by experimentation alone. Thus, computational chemistry
supplements experimentally derived data. Gary D. Wiggins, "What is Chemical
Informatics?" Indiana Univ., US, 2006
Related terms:
discovery informatics Computer Aided Molecular Design CAMD, molecular graphics
computational modeling: See ab initio modeling, homology
modeling, molecular modeling.
computational quantum chemistry:
is primarily concerned with the numerical computation of molecular
electronic structures by ab initio and semi-empirical techniques.
Overview of computational chemistry Shodor Educational Foundation 2999-2000 http://www.shodor.org/chemviz/overview/ccbasics.html
Computer Aided Molecular Design (CAMD): Involves all computer-assisted
techniques used to discover, design and optimize compounds with desired
structure and properties. IUPAC Combinatorial
Also known as molecular modeling or computational chemistry,
uses computers to analyze and model the physicochemical properties of a
molecule. CAMD programs allow integrated molecular design to take drug
discovery to a new level by using a more cross-functional team approach
to drug research and development. [Oxford Molecular]
conformational analysis:
Consists of the exploration of energetically
favorable spatial arrangements (shapes) of a molecule (conformations) using
molecular mechanics, molecular dynamics, quantum chemical
calculations or analysis of experimentally- determined structural
data, e.g., NMR or crystal structures.
Molecular mechanics and quantum chemical methods are employed to compute
conformational energies, whereas systematic and random searches,
Carlo, molecular dynamics, and distance geometry are methods
(often combined with energy minimization procedures) used to explore the
conformational space. IUPAC Computational
design: Drug
discovery informatics
factorial design FD:
An experimental design technique in which each
variable (factor or descriptor) is investigated at fixed levels.
In a two- level FD, each variable can take two values, e.g., high and low
lipophilicity. IUPAC Computational
force field:
A set of functions and parametrization used in molecular
mechanics calculations. IUPAC Computational
Long-time simulations will pose a challenging benchmark for the force
fields employed in molecular modeling. One question is, how will proteins
and DNA that were described by the available force fields (and remained
stable over nanosecond periods) behave in microsecond simulations? The
high cost of long- time simulations will require that the issue is addressed
in a systematic way by providing standard cases against which simulations
can be tested Opportunities in Molecular Biomedicine in the Era of Teraflop
Computing: March 3 & 4, 1999, Rockville, MD, NIH Resource for Macromolecular
Modeling and Bioinformatics Beckman Institute for Advanced Science
and Technology, University of Illinois at Urbana- Champaign Related term: van der
Immersive Virtual Reality
IVR: New futuristic technique [which]
enables the user to literally become a part of his or her data and to use
additional senses. Although IVR has not yet enjoyed widespread use in scientific
disciplines, it has been cost- effective in architectural design. Nicholas J.
Hrib, Norton P. Peet "Chemoinformatics: are we exploiting these new
science?" Drug Discovery Today 5 (11): 483-485, Nov. 2000
discovery informatics
IUPAC International
Chemical Identifier http://www.iupac.org/publications/ci/2006/2806/4_tools.html
Lipinski's rules of five: See rules
of five
Represents the affinity
of a molecule or a moiety for a lipophilic environment. It is commonly measured
by its distribution behaviour in a biphasic system, either liquid- liquid (e.g.,
partition coefficient in octan-1-ol/water) or solid/liquid (retention on
reversed- phase high performance liquid chromatography (RP-HPLC) or thin- layer
chromatography (TLC) system). (See also Hydrophobicity).
IUPAC Medicinal Chem
molecular design:
The application of all techniques leading to
the discovery of new chemical entities with specific
properties required for the intended application. IUPAC Compendium Related terms:
drug design, ligand design, rational drug design.
molecular dynamics: A simulation procedure consisting of the
computation of the motion of atoms in a molecule or of individual
atoms or molecules in solids, liquids and gases, according to Newton's
laws of motion. The forces acting on the atoms, required to simulate their
motions, are generally calculated using molecular mechanics force
fields. IUPAC Computational Narrower term: ab initio molecular dynamics
molecular dynamics
A computer simulation developed to study the motion of molecules
over a period of time. MeSH 2010
molecular geometry:
molecular graphics:
A technique for the visualization
and manipulation of molecules on a graphical display device. IUPAC Computational
molecular mechanics:
The calculation of molecular conformational
geometries and energies using a combination of empirical force fields (Burkert
and Allinger, 1982).
Method of calculation of geometrical and energy characteristics
of molecular entities on the basis of empirical potential functions
(see force field) the form of which is taken from classical
mechanics. The method implies transferability of the potential functions
within a network of similar molecules. An assumption is made on "natural"
bond lengths and angles, deviations from which result in bond and angle
strain respectively. Repulsive or attractive van der Waals and electrostatic
forces between nonbonded atoms are also taken into account. Synonymous
with force field method. IUPAC Computational Related terms: energy function, force fields
molecular modeling, molecular modelling:
A technique for the investigation of molecular
structures and properties using computational chemistry and graphical
visualization techniques in order to provide a plausible three- dimensional
representation under a given set of circumstances. IUPAC Medicinal
Chemistry, IUPAC Computational
Journal of Molecular Modeling focuses on 'hardcore' modeling, publishing
high-quality research and reports. Founded in 1995 as a purely electronic
journal, it has adapted its format to include a full-color print edition, and
adjusted its aims and scope fit the fast-changing field of molecular modeling,
with a particular focus on three-dimensional modeling.Today, the journal covers
all aspects of molecular modeling including life science modeling; materials
modeling; new methods; and computational chemistry.Topics include computer-aided
molecular design; rational drug design, de novo ligand design, receptor modeling
and docking; cheminformatics, data analysis, visualization and mining;
computational medicinal chemistry; homology modeling; simulation of peptides,
DNA and other biopolymers; quantitative structure-activity relationships (QSAR)
and ADME-modeling; modeling of biological reaction mechanisms; and combined
experimental and computational studies in which calculations play a major role.
Scope note Journal of Molecular Modeling http://link.springer.com/journal/894
Molecular modeling applications use falls into two broad categories:
interactive visualization and computational analyses. ... Three of the most prominent uses of modern molecular
modeling applications are structure analysis, homology modeling,
and docking ... in essence, objective modeling revolves around three
different approaches (each based on different underlying physical and chemical
theories): molecular dynamics, molecular mechanics, and quantum
mechanics . All of these are concerned with developing a
unique solution to what is referred to as the "protein folding" problem
- designing and testing algorithms and applications that will reliably
predict 3-D structure from primary sequence. Christopher Smith "Molecular
Modeling - Seeing the Whole Picture with Modeling Software Packages" Scientist
12[17]:0, Aug. 31, 1998 http://www.the-scientist.com/yr1998/august/profile2_980831.html
Molecular modeling software includes AMBER, DOCK, MODELER, RasMol and
many other programs. Related terms: computational chemistry,
Computer Assisted Drug Design;
molecular graphics, molecular dynamics, molecular mechanics.
molecular models:
Models used experimentally or theoretically
to study molecular shape, electronic properties, or interactions; includes
analogous molecules, computer generated graphics, and mechanical structures.
MeSH, 1984
molecular recognition:
The ability
of biological macromolecules such as proteins and DNA to recognize selectively
and to bind to other species to form larger supramolecular complexes is
a key element in the extraordinarily diverse and controlled chemistry exhibited
by nature. Chemists today are increasingly interested in mimicking these
processes which involve 'molecular recognition' of one molecule by another
via formation of specific nonequivalent bonds between them and spontaneous
binding together of two to many thousands of molecules into well defined
supramolecular systems with new chemical properties. Industrially important
applications already include drug design, synthesis of stereo regular polymers,
affinity chromatography, crystallization, epitaxial growth and liquid crystal
displays. BD More and M.J. Dustin Molecular Recognition course, University
of Strathclyde, Glasgow, Scotland, 2000 http://www.strath.ac.uk/Departments/Chemistry/courseinfo/4thyear/13944.html
Related terms: molecular mimicry,
peptidomimetic, recognition site
Partial Least Squares PLS:
Projection to latent structures
(PLS) is a robust multivariate generalized regression method using projections
to summarize multitudes of potentially collinear variables (Wold et al.,
1993). IUPAC Computational
pattern recognition PR:
The identification of patterns in large
data sets using appropriate mathematical methodologies. Examples
are principal component analysis (PCA), SIMCA, partial least squares
(PLS) and artificial neural networks (ANN) (Rouvray, 1990;
Van de Waterbeemd, 1995ab) IUPAC Computational Narrower terms: artificial neural networks,
pattern recognition, principal component analysis (PCA), SIMCA, partial least squares
"plug and play" systems:
for effective chemoinformatics systems. Must be designed backward from
the answer to the data to be captured and systems should be in components
where each component has one simple task…modular systems that can "plug
and play" into other systems. Frank Brown "Chemoinformatics: What is it
and How does it Impact Drug Discovery" Annual Reports in Medicinal Chemistry
33: 375- 384, 1998
predictive data mining: Algorithms
& data analysis Used in structure- function correlations.
Principal Components Analysis PCA:
Computational approach to
reducing the complexity of, for example, a set of descriptors, by identifying
those features which provide the major contributions to observed properties,
and thus reducing the dimensionality of the relevant property space. IUPAC
Combinatorial Chemistry
A data reduction method using mathematical techniques to identify patterns
in a data matrix. The main element of this approach consists of the construction
of a small set of new orthogonal, i.e., non- correlated, variables derived
from a linear combination of the original variables. IUPAC Computational
Often confused with common factor analysis.
Neural Network FAQ Part 1 ftp://ftp.sas.com/pub/neural/FAQ.html
Quantitative Structure-Activity Relationships QSAR:: Mathematical relationships linking chemical structure and pharmacological
activity in a quantitative manner for a series of compounds. Methods which
can be used in QSAR include various regression and
pattern recognition
techniques. QSAR is often taken to be equivalent to chemometrics or multivariate
statistical data analysis. It is sometimes used in a more limited
sense as equivalent to Hansch analysis. QSAR is a subset of the more general
term SPC. IUPAC Computational
The building of structure – biological activity
models by using regression analysis with physicochemical constants,
indicator variables or theoretical calculations. The term has been extended
by some authors to include chemical reactivity, i.e. activity is regarded
as synonymous with reactivity. This extension is, however, discouraged. Related
term: correlation analysis. IUPAC Compendium
A quantitative prediction of the biological, ecotoxicological or
pharmaceutical activity of a molecule. It is based upon structure and activity
information gathered from a series of similar compounds. MeSH, 2001
attempt to correlate chemical structure with activity using statistical
approaches. The QSAR models are useful for various purposes including the
prediction of activities of untested chemicals. Quantitative structure- activity
relationships and other related approaches have attracted broad scientific
interest, particularly in the pharmaceutical industry for drug discovery and in
toxicology and environmental science for risk assessment. An assortment of new
QSAR methods have been developed during the past decade, most of them focused on
drug discovery. Besides advancing our fundamental knowledge of QSARs, these
scientific efforts have stimulated their application in a wider range of
disciplines, such as toxicology, where QSARs have not yet gained full
appreciation. Synonomymous? term: QSPR: Quantitative Structure Property
Relationship Related terms: Algorithms glossary SAR Structure Activity Relationship; Hansch
analysis; Drug discovery &
development drug design; Pharmacogenomics
quantum chemical calculations:
Molecular property calculations
based on the Schrödinger equation, which take into account the interactions
between electrons in the molecule. IUPAC Computational
quantum mechanics:
The laws of physics that apply on very small scales. The essential feature is that energy, momentum and angular momentum as well as charge come in discrete amounts called quanta.
More... SLAC Glossary, Stanford Linear Accelerator Center, Stanford Univ. US http://www2.slac.stanford.edu/vvc/glossary.html#sectQ
Narrower terms: ab initio quantum mechanical methods, ab initio quantum mechanical
modeling, semi- empirical quantum mechanical methods
recursive partitioning:
Process for identifying complex structure-
activity relationships in large sets by dividing compounds into
a hierarchy of smaller and more homogeneous sub- groups on the basis of
the statistically most significant descriptors. Related terms: clustering,
principal components analysis.
IUPAC Combinatorial Chemistry
regression analysis:
The use of statistical methods for
modeling a set of dependent variables, Y, in terms of combinations of
predictors, X. It includes methods such as multiple linear
regression (MLR) and partial least squares (PLS). IUPAC Computational
rules of five: Lipinski's rules.
Set of criteria for predicting the oral bioavailability of a compound on
the basis of simple molecular features (molecular weight, CLogP,
numbers of hydrogen- bond donors and acceptors). Often used to profile
a library or virtual library with respect to the proportion of drug- like
members which it contains. IUPAC Combinatorial
An algorithm,
developed by Christopher A. Lipinski (of Pfizer) and colleagues, in which
many of the cutoff numbers are five or multiples of five. There are actually
four rules, and Pfizer has developed a additional number of criteria for
adoption of lead candidates. Advanced Drug Delivery Research 23: 3- 25, 1997.
Reducing the
investment made in likely drug development failure. CHI's Genome Link 15.1
Christopher Lipinski on the rules of five (see section 8.4) There are
actually 50+ rules now.
semi-empirical methods:
Molecular orbital calculations using
various degrees of approximation and
using only valence electrons. IUPAC Computational
semi-empirical quantum mechanical methods:
Use parameters derived
from experimental data to simplify computations.
The simplification may occur at various levels: simplification of the Hamiltonian
(e.g. as in the Extended Hückel method), approximate evaluation of
certain molecular integrals (see, for example, zero differential
overlap), simplification of the wave function (for example, use of p electron
approximation as in Pariser-Parr-Pople). IUPAC Computational
SIMCA (SIMple Classification Analysis or Soft Independent Modeling
of Class Analogy):
This method is a pattern recognition and
classification technique (Dunn and Wold, 1995). IUPAC Computational
"silo systems":
Legacy method for
many information systems, a system built to collect, store and report one
laboratory's data. Each "silo system" holds the data differently and may
be in a different technology … the results of the systems cannot easily
be interchanged … This is as much a corporate structure and resource problem
as it is a technical problem. Contrast with "plug and play". Frank
Brown "Chemoinformatics: What is it and How does it Impact Drug Discovery"
Annual Reports in Medicinal Chemistry 33: 375- 384,1998 Related
term: information silos
simulated annealing SA:
A procedure used in molecular dynamics
simulations, in which the system is allowed to equilibrate at high temperatures,
and then cooled down slowly to remove kinetic energy and to permit trajectories
to settle into local minimum energy conformations. IUPAC Computational
stereochemical formula
A three- dimensional view of a molecule either as such or in a projection.
IUPAC Compendium
stereochemistry: See stereochemical formula
Structure Activity Relationship
The relationship between chemical structure and pharmacological activity
for a series of compounds IUPAC Medicinal Chemistry
Compounds are often classed together because
they have structural characteristics in common including shape, size, stereochemical
arrangement, and distribution of functional groups. Other factors contributing
to structure- activity relationship include chemical reactivity, electronic
effects, resonance, and inductive effects. MeSH, 1972 Narrower terms:
3D-QSAR, QSAR; Related terms: NMR SAR by NMR ;
& data management cluster analysis, Principal Components Analysis PCA, recursive
based design, structure based drug design: Protein
Correlation SPC:
All statistical mathematical
methods used to correlate any molecular property (intrinsic, chemical or
biological) to any other property, using statistical regression or pattern
recognition techniques (Van de Waterbeemd, 1992). QSAR is a
subset of the more general term SPC. IUPAC Computational Narrower terms: 3D QSAR, QSAR
van der Waals forces: The attractive or repulsive forces
between molecular entities (or between groups within the same molecular
entity) other than those due to bond formation or to the electrostatic
interaction of ions or of ionic groups with one another or with neutral
molecules. ... The term is sometimes used loosely for the totality of nonspecific
attractive or repulsive forces. IUPAC Compendium
virtual database assembly:
A crucial activity as it enables access to
the large number of drug- like molecules that could theoretically be made... can
serve several purposes: for example, to generate a maximally diverse virtual
library for lead generation, a biased library aimed at a specific
target or
target family, or a lead optimization library. Nicholas J. Hrib, Norton P. Peet
"Chemoinformatics: are we exploiting these new science?" Drug
Discovery Today 5 (11): 483- 485, Nov. 2000
virtual library:
A library which has no physical existence, being
constructed solely in electronic form or on paper. The building blocks required for such
a library may not exist, and the chemical steps for such a library may not have been
tested. These libraries are used in the design and evaluation of possible
libraries. IUPAC Combinatorial Chemistry Related terms:
libraries & synthesis
virtual molecules:
It has also become clear that even the most
efficient combinatorial chemistry approaches can generate only a minute fraction
of the 1 x 1040 virtual drug molecules that could be prepared.
Timothy Ritchie "Chemoinformatics; manipulating chemical information to
facilitate decision- making in drug discovery" Drug Discovery Today 6(16):
813- 814, 16 Aug. 2001
virtual screening:
Assays &
ChemBioGrid related sites, Chemical Informatics
and Cyberinfrastructure Collaboratory, Indiana Univ., US, 2007 http://www.chembiogrid.org/related/index.html
Chemical Informatics Letters glossary, Jonathan Goodman, 2005, 100 +
definitions http://www-jmg.ch.cam.ac.uk/CIL/gloss.html
International Union of Pure and Applied Chemistry, Glossary of Terms used in
Computational Drug Design, H. van de Waterbeemd, R.E. Carter, G. Grassy, H.
Kubinyi, Y. C.. Martin, M.S. Tute, P.
Willett, 1997. 125+ definitions
Union of Pure and Applied Chemistry Glossary
of terms used in Biomolecular Screening 2011 http://iupac.org/publications/pac/83/5/1129/IUPAC
International Union of Pure and Applied Chemistry, Glossary of Terms used in
Computational Drug Design Part II Provisional
Recommendations, 2013 http://www.iupac.org/
International Union of Pure and Applied Chemistry, Glossary of Terms used in
Computational Drug Design, H. van de Waterbeemd, R.E. Carter, G. Grassy, H.
Kubinyi, Y. C.. Martin,M.S. Tute, P. Willett, 1997. 125+ definitions. http://www.iupac.org/reports/1997/6905vandewaterbeemd/glossary.html
International Union of Pure and Applied Chemistry Computation
Drug Design Glossary update, 2011 http://www.iupac.org/web/ins/2010-057-3-700
IUPAC International Union of
Pure and Applied Chemistry, Standard XML data dictionaries for chemistry,
current project http://www.iupac.org/projects/2002/2002-022-1-024.html
Open Babel, Avogadro & Molecular Modelling blog http://timvdm.blogspot.com/2009/09/symmetry-classes-how-to-get-them-and.html
Computational Chemistry Laboratory http://www.vcclab.org
glossary index
to look for other unfamiliar terms
IUPAC definitions are reprinted with the
permission of the International Union of Pure and Applied Chemistry.
| Privacy Statement |
Glossary List | Tips & glossary
FAQs | Site Map


text:
Do You Know What A Brony Is?Beth Anne Ballance
Yesterday I wrote about my 3.5 year old son's new obsession with My Little Pony and there were two immediate responses:
2 . Have you heard of Bronies?
I had not heard of "Bronies," so I immediately hit up Google and stumbled across this gem from Urban Dictionary:
Typically refers to 13-30 year old male fans of the 2010 reboot of the show My Little Pony: Friendship is Magic, but may also include females (see fillies).
Brony = Bro + Pony
While generally associated with a negative stereotype by outsiders, due to it's former 80's frilly girly-girl twinkle-toed tea-parties and all-female main casting, bronies are attracted to the new show by it's good animation, acting, writing, and humor.
Wait. So there's an entire culture of grown men that love My Little Pony?
Turns out there is, complete with conventions and tattooed "cutie marks" and websites/forums dedicated to the brotherly love of all things My Little Pony. It may seem a little odd at first, but there's nothing wrong or devious about it. Even Hasbro, the creators of My Little Pony: Friendship is Magic, have embraced the cult of bronies that now follow the show. They give vocal support to the Bronies and even released Brony convention-exclusive collector toys, which immediately sold out. There's even a study being held about Bronies as a way to explore the human fan phenomenon.
Even better, the group "Bronies for Good" raised over $60,000 in 2012 for the Children's Cancer Association.
Pony on, Bronies. I'll be proud if my son joins your ranks.
What are your thoughts on the Brony movement? Creepy or innocent imaginary fun?
More by BA:
Toddler Ear Infections: Causes and Solutions
Toddler Snoring: Causes and Solutions
How to make a cheap and custom toddler chore board
An interview with a toddler dad
Hilarious shirts to mock & shame the T-Rex.
How to be an awesome employer to parents
Beth Anne writes words & takes pictures at Okay, BA! You can also find her on the Twitters & Facebook


text:
1st Annual John Henry Memorial Authentic Blues & Gospel Festival. August 31 - September 2, 1973
Charleston, WV: John Henry Memorial Committee, 1973. First Edition. Memorial booklet for the first annual John Henry Memorial Blues Festival, held Fitzpatrick's Park in Beckley, WV in 1973. The three-day festival included performances by more than 20 traditional musicians from the Appalachian region, including Johnny Shines, Nimrod Workman, Uncle Homer Walker, C.C. Richardson, and many others. Rare; not located via OCLC; none others in commerce. Octavo (21.5cm). Staple-bound, pictorial wrappers; [32pp]; illus. Fine.
Price: $60.00


text:
New subscription
Renew my subscription
Give a gift
Pay my bill
Change my address
Active within 1639 Days
Hi! My name is Charlie
I am a Bombay from Fayettville, NC
Nicknames: Charles,or, Charlie The Unicorn
Age: 6 years old
Gender: M
Coat: short haired
My favorite tricks and treats are: No.
Where I hang out: On the bed or outside
My favorite grubs: cat food, mice, rats, birds, ect.
My pet peeves:
What I love about my owners: I like to be petted, and rubbed under my chin.
My cat hobbies: Hunt.
Pet motto: Charlie the unicorn MEOW MEOW MEOW
See all awards »
It was Just soo cute!!!
I've had 687 friends visit me.
I'm the 51,818th member on CatChannel.com.
10 friends have voted for me since I joined Club Cat!
Come visit me, Team RAGDOLL PAWesome PURRsonality #235194, :¦:Chloe:•:(¯`v´¯):•- :208036:¦: & Team CHLOE, a PAWSitively PURRfect NAME #234964.
Come visit me, Angel My Valentine is Eddie, Smokey, Angel Sassy Welcoming new Angels, Q Angel Spunky 5/2013 & Q.Angel Callie 4/ 2010. Going to miss my CC family.
Come visit me, Shadow <3 Button, Yoda- <3 Strudel-she said yes!!!, manchester &,snuggles,elivs & kali house, Sir Manchester <3 Queen Snuggles & SIR M's & ANA'S ANNIVERSARY #247289.
Tell a Friend |
Report inappropriate content on this page.
Hi, my name is
Angel Bailey (9/7/02 - 12/20/14).
Visit the photo gallery to cast your vote »
Get quick tips for happy cats, food recall info, news alerts and best behavior advice.
Sign up to get updates delivered straight to your inbox.
CatChannel takes your privacy seriously. To learn more, please read our privacy policy.


text:
European Commission Quantifies Cost of Climate Impacts
25 June 2014: Climate change-related damage could cost the EU €190 billion or more unless further climate action is taken, according to a study by the European Commission's Joint Research Centre (JRC). The study seeks to quantify the biophysical impacts of climate change on household welfare and economic activity by examining climate impacts on ten sectors in five EU regions through a broad set of climate model simulations.
The report, titled 'Climate Impacts in Europe,' is the result of the JRC's Projection of Economic impacts of climate change in Sectors of the EU based on bottom-up Analysis II (PESETA II) project, which examined sectoral and regional patterns of climate change impacts in Europe for the 2071-2100 time horizon. The project methodology is based on bottom-up biophysical impact models, and characterized by consistency in data use across all models and consideration of other horizontal issues. The study considers ten impact categories: agriculture; energy; river floods; droughts; forest fires; transport infrastructure; coasts; tourism; habitat suitability of forest tree species; and human health.
The study concludes that, if global temperature increases by 3.5°C, household welfare losses could amount to nearly 2% of the EU's current GDP. Doubled frequency of weather-related extremes could: lead to 200,000 heat-related deaths; result in 8,000 km2 of burned forests; cost €10 billion in river flood damages; and increase the number of people affected by droughts seven-fold. In addition, coastal damage could more than triple due to sea-level rise.
The study also finds an asymmetric geographical distribution of climate change-related damages, with the highest losses occurring in Southern Europe. It finds that over half of overall expected financial damages in the EU would be caused by additional premature mortality. In a 2°C world, however, climate damages, at €120 billion, would be reduced to 1.2% of the GDP.
Noting that "no action is clearly the most expensive solution of all," Connie Hedegaard, European Commissioner for Climate Action, underscored the need to "invest in reducing our climate impacts and becoming a competitive low-carbon economy," rather than pay for the damages. She emphasized the importance of a decision on the EU's 2030 climate and energy framework in October 2014 in this regard.
The JRC, a Directorate-General of the European Commission, is the Commission's in-house science service, tasked with providing independent, evidence-based scientific and technical support to EU policies. The JRC PESETA II project seeks to contribute to the EU Strategy on Adaptation to Climate Change, adopted by the European Commission in 2013, by providing background information on expected climate change impacts on a broad range of areas across the EU. [JRC Press Release] [PESETA II Project Website] [Publication Website] [Publication: Climate Impacts in Europe] [The JRC Science Hub] [EU Strategy on Adaptation to Climate Change]


text:
Thursday, April 18, 2013
Dear Editor:
Recent reports indicate that too many high school graduates have an elementary education level in math and science. Why is it that most foreign children coming to America seem to excel in all subjects? Could it be that in their country of origin, nothing is taken for granted nor is there any such thing as political correctness?
Today's teachers are stymied by the PC crowd. If one child in a class of 30 does well, he/she cannot be given a prize of any kind for the other 29 would be "offended" according to their parents. Those little sticky stars that teachers used to put on top of test papers for overachievers: no longer allowed.
I wonder why kids whose parents attend parent/teacher meetings do so well? Could it be they listen to the teacher and ask where their child needs help? Shouldn't students that excel be given recognition and encouragement?
There was a time when children that could not maintain average grade levels could be held back. Now, that is not politically correct. Should a teacher reprimand a student with anything but a very calm warning, a lawsuit could ensue.
Teachers are dedicated people and it takes the patience of Job to deal with some of the challenged children that all teachers see. They are not psychiatrists or nurses, and they need all the help they can get. Maybe our legislators can vote our teachers a raise instead of themselves.
With today's economy, both parents – if there are two parents – are working to make ends meet. Love, nurturing and encouragement are critical to our future generation. Time is of the essence.
Dave Jacobson
Goose Creek
© 2016 The Gazette an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
• We nonselectively interviewed 11 patients aged 3 through 16 years who had survived critical illnesses, including cardiac arrests and profound comas. Any memory of a time they were unconscious was considered to be a near-death experience (NDE) and was recorded. Seven of these children had memories that included (1) being out of the physical body (six patients), (2) entering darkness (five patients), (3) being in a tunnel (four patients), and (4) deciding to return to the body (three patients). We also interviewed 29 age-matched survivors of illnesses that required intubation, narcotics, benzodiazepines, and admission to an intensive care unit. None of them had any memories of the time they were unconscious. In our study population, NDEs were clearly associated with surviving a critical illness. The elements of NDEs reported are similar to those previously described in adults. No children described elements of depersonalization as part of their NDEs. A core NDE, triggered by the process of dying or resuscitation efforts, may be a natural developmental experience. We present a neurophysiologic hypothesis as to the cause of NDEs.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Pediatrics editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers' bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Need assistance?
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.


text:
News & Announcements
Watch this space for all your event news and announcements!
Hello Muscle Walkers!
Colorado Springs Muscle Walk is TWO days away! I hope you are excited to spend a morning walking for those fighting muscle disease, and a fun afternoon outside with your Colorado Springs community members!
IMPORTANT DAY OF FAQ - Please read the following in its entirety:
Location: America the Beautiful Park, 126 Cimino Dr,
Colorado Springs, CO
Parking: Lot directly across from registration;
signage will be posted.
Registration and Walk Times: 9:30 am Registration Start, 10:00 am Registration close .Walk Start 10:05am, Awards and Thank You presentation immediately following the finish of Walk
MDA Staff and Volunteers: MDA Staff will be in MDA Shirts with name tags available for any questions. Walgreens is generously volunteering their time prior to and during the event. Boy Scouts will be generously volunteering their time to help with the cleanup of the park after the conclusion of walk.
Unregistered Participants and Spectators: We encourage you to bring as many people as you would like to join your team or cheer you on at the finish line. EVERYONE must register and sign waivers to be allowed into the walk and/or
Registration/Check In: ALL persons, including those under 18, MUST register and have a waiver signed prior to participating in
walk or entering the park to be a spectator. Participants registered online prior
to Friday, June 3rd, at 5:00pm need to check in and receive a
wristband. Participants and spectators that have not registered online prior to Friday, June 3rd, at
5:00pm MUST fill out registration
paperwork and sign a waiver at registration. If a participant or spectator is
under the age of 18, their waiver must be signed by a parent or guardian.
Wristbands and Security: You will receive a green wristband
at check in, and MDA kindly requests that all persons present wear these
throughout the event. If you see a person that is not MDA staff or a
volunteer without a wristband, please alert MDA staff immediately. If you
notice any suspicious activity, please alert a member of MDA staff immediately.
Family Picnic and Community Time: We encourage all
participants to bring a picnic blanket, chairs, sunscreen, and a cooler with
additional drinks and lunch. There will be a community hour following the walk
with time to enjoy our sponsor row, music provided by The Underwood Family, community
activities, and each other's company! Feel free to bring any games or outdoor activities
you enjoy such as corn hole or ladder ball. Per Park rules, NO ITEMS MAY BE
STAKED INTO THE GROUND IN ANY WAY. Please make alternative arrangements for any
items requiring stakes. You will be asked to remove any staked items by MDA
Water and Snacks: Bottled Water and Fruit will be
provided by MDA and Walgreens.


text:
Media Contact:
Leslie Hoffman – Black Elk Energy Offshore Operations, LLC
Houston, TX – 1 July 2013 - Black Elk Energy Offshore Operations, LLC, an independent oil & gas company, has teamed up with Bright Light Foundation to host a second special tribute sporting clay shoot called the West Delta 32 Fall Fundraiser. The event will be held on September 26th at American Shooting Centers in Houston, TX and includes a sporting clay tournament, BBQ cook-off, live auction, music, games and more. Proceeds will assist the families affected by the incident that occurred in the Gulf of Mexico on November 16, 2012.
"We are excited to work with the Bright Light Foundation for our Fall event", says John Hoffman, President and CEO of Black Elk Energy. "We held our first West Delta 32 Fundraiser in March with Oilfield Helping Hands and had a tremendous response. I am confident with the help of Bright Light this event will be another success. Please join us on September 26th in Houston to honor the victims of this tragic incident. We deeply appreciate any and all support."
About Bright Light Foundation
Inspired by the faith and courage of Tammy Bright and her family, the mission of the Bright Light Foundation is to raise funds, in the spirit of compassion and fun, to assist with the medical needs of those within the oilfield community stricken by catastrophic illness.
Since 2003, the foundation has raised funds to help recipients manage the high costs associated with illnesses. The foundation has grown in participation each year and in 2011 provided approximately $400,000 in financial support to eight recipients. (www.brightlightfoundation.org)
About Black Elk Energy
Black Elk Energy Offshore Operations, LLC (www.blackelkenergy.com) is an independent oil and gas company headquartered in Houston, Texas. The Company's seasoned industry executives have extensive exploitation experience and knowledge with a unique demonstrated track record of increasing reserves and production while lowering costs. Our team of professionals is dedicated to performing to the highest industry standards, operating within and beyond the requirements of the regulations, and maintaining its stance as a good corporate citizen.


text:
One of my old internet pals, Steven Burn, wrote me about finding malware in Kiwi Alpha, which is a peer to peer file sharing client. He found it at Download.com. He knows I've had bad experiences at Download.com in the past.
Steven sent me a link to a thread at SpywareWarrior's forums where he had posted his analysis of Kiwi Alpha. It looked bad, but naturally I had to try it for myself.
I created a clean Win98 virtual machine using Microsoft's free Virtual PC program. Then I googled for the page at Download.com. I found Kiwi Alpha and installed it in the virtual machine so that I could safely test it without infecting my PC.
Over the next few days, I scanned the program with four different anti-spyware tools and really didn't find much of anything. I wondered where Steven had gotten his copy of Kiwi Alpha because I noticed that the MD5 checksum was different from the one I had. It looked like we had scanned different files. Steven later confirmed that someone had replaced the infected Kiwi Alpha with a clean version. This apparently happened sometime between November 20th and November 23rd. Isn't that interesting?
In this case, Download.com is redirecting you to the KiwiAlpha website to download the file. This means that Download.com cannot truthfully guarantee the safety of anything you download from some of their pages. This is common at Download.com, so be aware of it when you go there.
I checked Google's cached copy of the Kiwi Alpha page at Download.com which was dated November 19th. At the time of this "snapshot", 800,000 people had downloaded copies of Kiwi Alpha. How many of these downloads had the WhenU/SaveNow and Relevant Knowledge adware in them? What does this tell you about Download.com's concern about the consumer who comes to their website?
Conclusion: Download.com claims to be "Safe, Trusted, & Spyware Free". How can they possibly say that? Three strikes and you're out. You can't keep us safe, I don't trust you, and you can't keep your third party downloads spyware free.
In my opinion, this isn't the worst practice there. They also provide "sponsored links" to websites that offer more downloads full of adware and other malware.
Example: (screen shot)
Make no mistake about it. Adware is big business and big money. Download.com is getting a piece of the action when they sponsor those websites that distribute adware or other malware.
I recommend that you stay away from Download.com. There are places I trust that offer almost everything I look for. You can find some of them here.
If you want details, I have a complete version of this article in my newsletter.
Drop on by sometime …


text:
Did somebody say April 21st was Shoe Lovers' Day? It may sound totally made up, but true-blue footwear...
La Moda Dubai is the authoritative online source for fashion, beauty and luxury catering specifically to the UAE and greater Middle East region. Established in 2010, the La Moda Dubai fashion blog was conceived to provide breaking fashion and lifestyle news as well as in-depth features that provoke the imagination of the fine living connoisseurs of the Arabian Gulf.
Jim Paolo Joquico
Sherry Tenorio
Copyright © 2014 La Moda Dubai.


text:
If you're like me and have actually checked the zoning regulations on having a cow in a residential neighborhood to keep up with your child's milk consumption then this contest…
read more...
Tagged as:
cookie recipes,
Gary Aggus,
Hiland Dairies,
Hiland Dairy,
Hiland Dairy Butter,
Hiland Dairy Milk,
Red Diamond Tea
Find more in :
CQ Contests
Edmond Road Food Pantry
Young Living Essential Oils
Back To School Shopping Guide
Consumer Queen Holiday Gift Guide
Like us on Facebook
I'm A Part Of
Follow Us On Pinterest
Our Supporters
Contact The Queen!
Copyright © Consumer Queen All Rights Reserved. Disclaimer|Disclosure Policy|Privacy Policy|Contact Me|CQ MediaSite Design by Mitra4Design


text:
It's bikini time without cleavage :)
So, how can you get a bikini cleavage?
This is a tough one! Getting almost naked in front of people when you are not a supermodel is not that easy.
For your sake you need to look around you. Nobody's body is perfect, but there is something about everybody that looks good!
Breast Enhancing - Confidence Boosting Bikinis!
Here are the Cute Gel Bikinis :)
They are all HAND MADE IN HOUSE!!!! Great reviews from REAL customers!!
So if you have tiny breasts ask yourself:
1. Am I going to just lay down at the pool, sunbath and do just very moderate swimming, no jumping into the pool or playing beach ball?
2. Am I an active vacationer? Playing beach ball, lots of jumping and goofing around?
Shop for your swimwear according to that.
If you are a laid back person, happy with sipping yummy cocktails: get a push up bikini top with gel inserts. Brazilian Bikinis have a good cut, since the Brazilian Girls are smaller on top.
Try to find a top with adjustable straps at the shoulders and around the back. Avoid those where you just need to tie a knot.
No matter how tight you do it, they will get loose after a while. Your top has to be perfectly tight so you don't show any gap. Go for busy colorful patterns, those will make you look bigger.
Gel inserts are another option. They are perfect for light swimming. I wouldn't jump around in them but just for nice and easy swimming and cooling off activity they work very well.
Careful! If you are totally flat chested, I wouldn't recommend a push up top. If there is nothing to push up, you are better without it. Even if your top is really tight, you could show a gap and you don't want that. Try triangle tops instead. Triangle tops look really good on small breasts. Try it with a light padding. You will not go wrong there.
If you are an active one: go for padded built in push up bra tankinis or a one piece! They are so perfect. They can flatter your torso so nicely and the built in push up bra or padding will give you cleavage. You can jump or swim freely in these.
Take this advice:
Invest in excellent swimwear. Even if it seems more expensive. You are going on a vacation, you want to feel good and not to worry about your looks and compare your breasts to everybody! At summer time on a beach you are in your swimwear most of the time. It is more important to have a couple of really nice swimming outfit than any other accessories.
Use a push up top only if you are at least an A cup (or bigger) to get an even bigger bikini cleavage. Be honest here! While it is OK and I bet lots of us do use padded pushup bras to make our small breasts look bigger, unfortunately you will not be able to hide that gap with a bikini top.
For flat-chested girls the triangle bikini tops are the best bet with a little bit of padding.
BREAST ENHANCEMENT FROM AA to A cup size.
On the beach we expose not just our breasts but of course our legs as well. Get Great Legs: A guide to great legs for women. Tips for dealing with cellulite, varicose veins and stretch marks. Also great leg exercises, pampering tips and fashion.
Return Small Breasts Help from Bikini Cleavage
I have this amazing bikini above.
It will TOTALLY boost your bust with 1 cup!! :)


text:
The Maguire LPD:
A revolution in resin drying
The Maguire Low Pressure Dryer (LPD) is a revolutionary device that uses vacuum to accelerate the resin drying process. The use of vacuum provides many process and cost benefits compared to conventional drying technology.
Maguire Products did not invent the science of low pressure (vacuum) drying. In fact vacuum drying has been used in the manufacturing process of plastic resins, chemicals, food and pharmaceuticals for many years. But, Maguire Products is the first to bring this technology to the plastics industry in a package that is affordable, reliable and simple to operate.
Why is the LPD Better?
Tel: 610-459-4300
Fax: 610-459-2700
Email: email@example.com
How the LPD Dryer Works:
The dryer operates with 3 Stainless Steel canisters that are mounted directly onto a carousel that indexes counterclockwise 360 degrees. Through this 3 step process each canister systematically goes through the following 3 stages to dry materials.
Stage 1:
Filling: In the first stage the canister is filled with material using a specially designed dispense valve to ensure the canister can never overfill. Mounted above the dryer is a surge hopper for material resin which ensures the canister can be filled in the minimum amount of time necessary.
Heating: As the canister is being filled the heating process also begins. Temperature settings are made easily by simply dialing in the required temperature on the thumbwheels of the controller.
Due to the relatively small volume of the canisters when compared to traditional large drying hoppers the material can come up to the required temperature rapidly. Once the canister has been heated for the time set it will then index automatically to the next stage.
Stage 2:
Vacuum: When the canister indexes from Stage 1, it is sealed and very strong vacuum is applied. As air pressure drops, water boils at lower temperatures. Once the material is under vacuum, the boiling point of water falls from 212ºF (100ºC) to 133ºF (56ºC). Moisture is rapidly driven from the material and evacuated to ambient air. The dryer controller continuously monitors vacuum level ensuring the vacuum remains high. If the proper level of vacuum is not maintained an alarm will sound.
Stage 3:
Material Removal: After the Vacuum cycle is completed the canister indexes again to the material take off position. Under automatic operation a valve in the bottom of the canister is opened and material then flows from the canister into a material take off pan. Dry material is then drawn by a vacuum loader to the process machine. Material level in the takeoff pan is monitored continuously by a proximity sensor. At the end of the cycle time the canister will index back to Stage 1.
Changing Materials on the LPD Dryer
The dryer comes with an innovative and time saving Clean Mode. When this is selected as soon as the proximity sensor detects that all material has been removed from the canister or the cycle time has expired, it will notify the operator by alarm. This allows for the canister to be quickly removed, cleaned and prepared for a new material.
Canister Removal and Cleaning:
Each canister is easily removed from the central carousel by releasing two latches.
Once the canister is removed and emptied all material contact surfaces can be readily accessed for quick and simple cleaning. By turning the canister upside down operators can access the screen by rotating the retaining plate and then both the plate and the screen are removed for complete cleaning.
Surge Hopper Removal and Cleaning:
The surge hopper above the dryer is also designed to be quick and easy to remove. The lightweight hopper includes a shut-off slide gate and can be easily lifted out. The frame can then be rotated out of the way, allowing access and removal of the fill valve.
Material Take-off Pan Cleaning:
The material take off pan slides out of position for complete access and easy cleaning.
Filter Cleaning:
The dryer includes a filter that protects the blower from any carry-over of dust or fine particles. The filter requires cleaning periodically and this can be achieved by removal of the quick access panel on the front of the dryer.
* US voltage: 480, Europe / Asia voltage: 400
Please note the following:
*Final moisture content as recommended by the raw material manufacturer.
**Recommended cycle time is based on average initial moisture content. For high initial moisture content cycle time should be extended 5 minutes. When in doubt please contact Maguire service.
***Drying temperature as recommended by the material manufacturer.


text:
*The follow prices listed are for Pink House members
Check us out on Facebook Follow @TheCherryCo
Open 7 Days a Week | 10am ~7pm | Phone # 303.399.6337 (MEDS)
Located at 111 S. Madison on the Southwest corner of Madison and Bayaud just two blocks East of the Cherry Creek Shopping Center, and two blocks North of Alameda.
Veiw In Google Maps for Directions
The Cherry Co. has been serving patients in a welcoming warm environment since early 2010.
We offer a wide selection of strains and extracts as well as accessories to compliment all of your medicating needs.
We also offer these select products:
Vector KGM: A tool needed in an arsenal to accelerate the smoking experience to the next level.
Bee Line: Fine organic Hemp wick fueled by beeswax for an all natural higher quality flame to enhance the smoking experience