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Adapting to Evolving Business Environments Is...
Nothing Beats Immunoassays for Sensitivity, Specificity,...
Quadruple Helices Appear To Have Role...
Beware of Obstructions in the Upstream...
The bivalent ion Ca2+ is a critical second messenger involved in many physiological and signal transduction processes within a cell. The central role of Ca2+ in intracellular signalling, and its physical/chemical properties also makes it an attractive reporting molecule for drug discovery.
GPCRs, ion channels, and ion exchangers are among the most interesting target classes for the pharmaceutical industry. The majority of these target classes frequently trigger an intracellular Ca2+ mobilization upon activation with specific stimulating molecules. These reporting activities are commonly used in the search for agonists or antagonists of the target classes mentioned above.
The development of more sensitive and reliable technologies that measure transient changes in intracellular Ca2+ concentration continues to be an important research area. However, there are inherent challenges in developing precise Ca2+ mobilization assays for high-throughput screening (HTS) applications, since the Ca2+ release signal is rapid, short, transient, and sometimes weak.
The introduction of the Fluorometric Imaging Plate Reader (FLIPR, Molecular Devices), an image-based instrument capable of measuring 384 wells simultaneously, has allowed extensive use of fluorescent dye-based Ca2+ mobilization assays in the HTS process.
A valid alternative to the fluorescent-based Ca2+ mobilization assays is represented by the use of Ca2+-activated photoproteins with their inherent property of flash luminescence. The binding of Ca2+ ions to the active complex, consisting of the apo-photoprotein and coelenterazine, induces a conformational change, resulting in the oxidation of coelenterazine to coelenteramide with a subsequent emission of a blue light flash.
The use of photoproteins as indicators of Ca2+ activation in HTS offers many advantages: low background levels result in a large signal to noise ratio; Ca2+ concentrations can be measured at specific cellular sites; tested compounds only require short incubation periods; and reaction kinetics can be followed.
Aequorin, the first photoprotein to be isolated, has been validated for functional assays of many GPCRs, and the results obtained are comparable to those obtained with the use of fluorescent dyes. However, the adaptation of aequorin assays to HTS is not always easy due to the low quantum yield of aequorin and the fast kinetics of the reaction. Photoproteins capable of emitting a brighter signal and addressing targets other than GPCRs are therefore of importance for the HTS industry and could overcome some of the drawbacks of aequorin.
Axxam (www.axxam.com) has developed a Ca2+-activated photoprotein called Photina as a result of the development of reporter cell-based assays for HTS. Photina has the mechanism of action of a typical photoprotein, but the total light release is higher, and the reaction kinetic is slower.
Photina is a chimeric photoprotein created by replacing a portion of the obelin-coding sequence, located between EF-hand I and EF-hand II, with the corresponding part of the clytin sequence. To increase the expression for the chimeric protein in mammalian cells, a Kozak sequence was introduced, and codons were optimized for mamalian expression in regions with a very high (>80%) or with a very low (<30%) GC content.
The expression and functionality of Photina was tested in different cell lines frequently used in HTS processes, such as CHO and HEK293 cells. The results obtained showed that the expression of the protein is stable over time, does not affect cell growth and viability, and no toxicity is detected even after long periods of cell culture.
One of the most important differences between Ca2+-activated photoproteins and Ca2+ fluorescent dyes is that photoproteins can be transported to subcellular compartments of interest using the appropriate targeting sequences. As a result, Photina has been targeted to different cell compartments where the variation in Ca2+ concentrations has a particular physiological meaning, such as plasma membranes or mitochondria.
The localization of a Ca2+-activated photoprotein within the mitochondria has the advantage of amplifying the luminescent response triggered by the activation of GPCRs coupled to the Gaq/PLC pathway. Axxam has found that the transient flash luminescence is at least 10-fold higher than that obtained by the same stimulus applied on cells containing a cytoplasmic version of Photina (Figure 1).
Apart from monitoring GPCRs activity, Photina allows the signal detection for any cellular target that can increase the intracellular Ca2+ concentration. To assess this, several different targets like Ca2+ permeable ion channels or Na+/Ca2+ exchangers have been transfected in CHO cells that express either the mitochondrial or the cytoplasmic version of Photina. The results obtained clearly demonstrate that the functional activation of these targets can be detected easily and reliably by Photina.
The choice between cytoplasmic or mitochondrial localization of the photoprotein greatly expands the range of targets addressable by the use of flash luminescence. Generally, the cytoplasmic localization of Photina is more suited to the study of Ca2+ permeable ion channels and Na+/ Ca2+ exchangers, but there are cases in which the use of a mitochondrial localization is preferable (Figure 2).
For ion channels like the ionotropic purinegic receptors P2X1 or P2X3, instruments will generally miss the very fast activation kinetic, since the widespread cytoplasmic localization of Photina results in immediate detection of the Ca2+ wave of functional channel modulation. The same target could be more easily studied by transfecting it in a CHO cell line expressing the mitochondrial version of Photina. The spatially restricted localization of the photoprotein within the mitochondria allows a more accurate detection of the channel activation kinetic. This is due to the longer time needed for the Ca2+ wave to reach the mitochondria-localized Photina.
The different cell-based assays expressing Photina and receptors of interest, such as GPCRs, ion channels, and Na+/Ca2+ exchangers, have been validated using most leading types of flash luminescence plate readers and with different plate formats. The results obtained show robust and reproducible light signals that present new insights and applications for photoprotein-based cellular assays for HTS. In all tested conditions, the light intensity generated by the Ca2+-activated Photina is high and allows the use of few cells/well compared with the usual quantity required by most other HTS protocols.
Figure 3 demonstrates that the signal intensity obtained with 250 cells/well is already strong enough on some instruments to guarantee reliable signal detection, implying that Photina has a light emission much stronger than most other known photoproteins. Photina is, therefore, particularly attractive for those HTS campaigns involving large compound collections, as the required production quantity of the cellular assay material is significantly reduced. An overall average Z' factor value of 0.7 for most of the tested assays also provides the required robustness for application to HTS.
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Any street where some balla, goon or other thug stops his car in the middle of it while he hollas at his homies or a ho, usually impeding traffic.
If you drive through tha hood, be prepared to run into a ghetto parking lot.
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In this video, Matt Koppenheffer describes the one key opportunity for AIG (NYSE: AIG ) investors. Matt believes the company's valuation makes it an attractive investment. AIG currently trades at a 40% discount to its tangible book value, far less than what it traded for before the financial crisis. Matt suspects lingering memories of that financial crisis lead investors to avoid the stock. There are also concerns that AIG's core businesses aren't that good relative to the past. Matt believes AIG's property and life insurance businesses are solid and, especially if interest rates increase, will contribute to the financial success of the company.
At the end of last year, AIG was the favorite stock among hedge fund managers. Have they identified the next big multi-bagger, or are the risks facing the insurance giant still too great? In The Motley Fool's premium report on AIG, Financials Bureau Chief Matt Koppenheffer breaks down the key issues that you need to know about if you want to successfully invest in this stock. Simply click here now to claim your copy, and you'll also receive a full year of key updates and expert analysis as news continues to develop.


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This treatise provides health law practitioners and e-health professionals with a full exploration of the legal, regulatory, transactional, and ethical issues at the nexus of health and information technology, including e-health, privacy, security, social media, HIPAA, HITECH, and more. It also includes guidance on maximizing technology to cut costs and improve marketing, all while staying compliant and avoiding penalties.
To qualify for a 25% discount use WEB16 as Coupon Code at checkout.
CLEAR INFORMATION on the full range of today's e-health business and transactional law issues
E-health has rapidly emerged as one of the most dynamic and fastest-growing areas of the health care industry. As the industry becomes more dependent on information technology, health law practitioners are increasingly confronting unfamiliar legal issues. E-Health, Privacy, and Security Law, with CD-ROM, Second Edition offers clear guidance on the full range of today's e-health business and transactional law issues with a new focus on the liabilities and ethical issues associated with the increased use of health information technology, social media, and digitized patient records and discusses such important topics and trends as: personal health records and social media; FDA regulation of e-health technology; special issues regarding electronic health information and litigation; the latest regulations on privacy and security issues under the HITECH Act; and new enforcement techniques and practices.
The Second Edition contains a comprehensive discussion of new HIPAA enforcement actions, including the first State Attorney General enforcement action under the HITECH Act and the first impositions of civil money penalties and jail time for criminal actions under HIPAA.
This treatise also is useful for e-health professionals, who will value its indispensable analysis and advice to help them avoid penalties and jail time; maximize the use of technology to increase efficiency, cut costs, and improve marketing; and complete e-health strategic transactions successfully.
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CHAMPION - A fundraiser held at Kent State University at Trumbull to raise money for victims of the 2011 earthquake and nuclear accident in Japan was also an opportunity to say thank you for assistance given by American citizens and military personnel.
"I wanted to tell the American people how much the victims appreciated their help," said Kimi Itagaki-Lynch, KSU graduate student and staff member.
"Arigato. That's one of our sayings," she said, explaining the Japanese term translates to 'Thank you, America.'
Article Photos
Kent State University graduate student and staff member Kimi Itagaki-Lynch, left, assists Bob Fejko, 66, of Champion, with raffle tickets Thursday during a fundraiser at the Trumbull campus in Champion for victims of the 2011 Japan tsunami and nuclear accident. Itagaki-Lynch sold Japanese goods, delicacies and desserts during the fundraiser. Photo by Bonnie Hazen
Itagaki-Lynch held the second annual event on Thursday to raise money and awareness of mental and financial hardships suffered by people in the aftermath of the tragedy in which more than 19,000 died. Many of those who survived lost their homes, family members and friends.
"Those kids, even victims, are saying they want to be something, they want to help people because they got a lot of help," she said. "They need an education (to do that)."
Bob Fejko, 66, of Champion, came down to offer his support of the fundraiser with a friend.
"I wanted to help the kids. It's a good cause. They got devastated," he said.
Itagaki-Lynch moved to the United States 10 years ago, and although her family in Tokyo were unharmed, she still considers the many victims to be family and friends.
"I couldn't stop crying. I needed to do something," she said, explaining that a growing nostalgia for her former country motivated her to hold the first fundraiser last year.
Itagaki-Lynch and her husband, Michael Lynch, an American English professor who had been teaching in Japan for several years and currently teaches at Kent State at Trumbull, were in Japan last summer and were able to see the needs of the children. Last year, they matched the money raised by the event, providing $800 for the cause.
This year's total surpassed last year's, which the couple again will match for a total of $820.
"We feel like we're doing a very small part, but every cent counts to help them," said Joyce Amick, academic coordinator for Kent State University at Trumbull Learning Center, who assists Itagaki-Lynch with the event.
"It's been two years since the disaster, and I'm so happy that she's doing as well as she is. When two years go by, people start to lose interest sometimes," she said.
This year's event featured various Japanese goods, crafts and snacks as well as a basket raffle with assorted Japanese snacks and souvenirs and gift cards donated by area businesses.
Many Kent staff members assisted Itagaki-Lynch with coordinating the event, some providing baked goods.
"(The Kent community) love to help each other. They're great," Amick said.
Itagaki-Lynch said she will continue to hold the fundraiser each year for as long as she receives the support.
"I always appreciate however much is possible," she said.


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News and videos. 40,000 subscribers and growing
Autopsy report: High Point woman was beaten, strangled
Hearing for High Point man charged with killing wife set for May 10
HIGH POINT — The state medical examiner has released the autopsy for a 23-year-old woman who police said was beaten and strangled by her husband.
Arab Mohamed Ali, 33, was arrested on a first-degree murder charge in February in the death of his wife, Safaya Dadacha, according to the High Point City Clerk's office. He is being held without bond in the Guilford County jail in High Point.
The autopsy shows evidence of head trauma from a blunt instrument and bruising around Dadacha's neck indicating she was strangled.
Ali remains in custody at the High Point Jail and has a court appearance in High Point's District Court for a probable cause hearing on May 10.
"We are going to go full force with the prosecution of the case," said Walt Jones, head of the High Point District Attorney's office. "We are certainly committed to prosecuting the case and attaching all the seriousness to it that it demands."
Police responded to the a domestic disturbance call at the couple's home, 2113 Wingate Place, at 2 p.m. on Feb. 18. They found Dadacha unconscious inside the home, along with blood on the walls, according to police reports. Ali was the one that made the call to emergency personal.
Dadacha was taken to High Point Regional Hospital, where she died in the Intensive Care Unit from her injuries the next day. The couple's two children, ages 2 and 4, were home at the time and were taken into the custody of the Department of Social Services.
The Ethiopian woman's death was the city's first homicide this year.
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Thieves have hit a jewelry store in downtown Manchester for the second time in one week.
The alarm went off at Pearson's Jewelry just after 3:30 a.m. Monday.
The front glass was shattered, and several display cases were taken. Watches, rings and necklaces are now missing.
There was a similar break-in at the same business exactly one week earlier.


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Caribbean Dialogue Discusses HLP Report, Post-2015 Agenda
25 July 2013: The Secretariat of the UN High-level Panel on the Post-2015 Development Agenda (HLP) and the International Planned Parenthood Foundation (IPPF) hosted a Caribbean Dialogue on the HLP and the Post-2015 Agenda, via teleconference, on 25 July 2013. Speakers from Latin America and the Caribbean (LAC) shared their perspectives on the final report of the Panel, highlighting remaining issues to be addressed, and responded to questions.
Ambassador Patricia Espinosa, Government of Mexico and HLP member, welcomed the report's goal of eradicating extreme poverty and emphasized connections between the developed and the developing world, calling for "stronger responsibility across countries for the future development agenda."
Dona Da Costa Martinez, Family Planning Association of Trinidad and Tobago, stressed that some issues continue to be "taboo" in the region, and noted the inability to "situate sexual and reproductive rights in a development conversation," which she said could contribute to negative outcomes on gender equality, health and poverty in LAC. She pointed to limited implementation of agreed commitments in this regard and a need to increase the scope of policy and legal frameworks. She recommended supporting national networks of civil society organizations (CSOs) to contribute to such efforts, including by reestablishing the Caribbean Women's Desk and strengthening the National Women's Department. Diane Quarless, Economic Commission for LAC (ECLAC), highlighted gender-based violence and climate change as significant Caribbean issues.
In response to a question on the next steps in the Caribbean on the post-2015 consultations, Diego Antoni, UN Development Programme (UNDP) said efforts are underway to synthesize LAC consultations, including six that took place in small island developing States (SIDS), and he said dialogues and information sharing will continue. He noted that future efforts will also include a focus on stronger field-level engagement. [Dialogue Audio File and Report Summary]


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Projects throughout the United States showcase how construction materials are playing a supporting role in industries where new technology rollouts, tight timelines, and sustainable design are the new norm. Fast-setting, calcium sulfoaluminate (CSA) cement-based products are increasingly the key to achieving demands for both new and renovated construction.
Polished concrete flooring projects surge


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Edwards' annual directory to the inhabitants, institutions, incorporated companies, manufacturing establishments, business, business firms, etc., etc., in the city of St. Louis for ... /
Enrolled Missouri Militia.
Head Quarters—116 Market street.
H. r.residence Gamble, , Governor of the State and Com-
mander-in. Chief.
mander-in. Chief.
John b.between Gray, , Adjutant General .
Col. A. r.residence Easton., Inspector-General .
Anson e.east Moore., Quarter-Master General .
T. T.More, , Military Store Keeper , 29 and 31
Washington av.avenue
Washington av.avenue


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You will read many answers on how to treat a yeast infection in your research. There are a few things that you should keep in mind.
Many friends will try to give advice. Maybe a pill, or lotion that they tried and it worked. Maybe a home remedy that was handed down through the years. But the main question that you should be asking is "Did the treatment get rid of the yeast infection permanently?" Is this really how to treat a yeast infection?
Sure you can run down to your local Walmart and come home with some quick fix product that offers fast relief. But is it temporary? Is it healthy for you? Normally your yeast infection will come back. And not only will it come back, but it will probably be worse.
If you really want to know how to treat a yeast infection, look for the all natural holistic method that treats your yeast infection permanently.
Your yeast infection did not happen overnight, and neither will a permanent cure. A yeast infection is a sum of more than one thing going on in your body. And if you want to be yeast free forever, you must treat all of the problems.
There are many foods that you should be eating and some that you should avoid. You will have to make some lifestyle changes. It will not be an easy process, but most things worth having require effort.
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Visit Linda Allen's site at: Yeast Infection No More for more information on how to treat a yeast infection and to read some testimonials of many yeast free customers. Isn't it time that you learned the all natural way of how to treat a yeast infection today!


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One person was hurt in a crash in Butler County on Friday morning.
Butler County 911 dispatchers said a car crashed into a pole on Bonniebrook Road in Jefferson Township shortly after 1:00 in the morning.
The person who was injured was taken to the hospital.
As of Friday morning there was no word on what caused the crash.
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Hello from California
Hi There!! I'm from CA, too! So happy you are here, welcome to Gingerscraps!!
Proud CTM for Gingerscraps and JB Studio
another hello from sunny CA, welcome to GS
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Hello and welcome!
Hi and Welcome, I can say...I've been to California, LOL. I've visited a couple towns. Welcome to Ginger Scraps and the wonderful world of digi. Jump in and have fun with us.
Welcome to GingerScraps from another Cali girl!
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Current Immunology Reviews (v.7, #4)
Editorial [Hot Topic: Clinical Trials in ANCA Associated Vasculitis (Guest Editor: Chetan Mukhtyar)] by Chetan Mukhtyar (385-387).
Wegener's granulomatosis (WG) was described in 1936 [1], Churg-Strauss syndrome (CSS) in 1951 [2], and microscopicpolyangiitis (MPA) was formally recognized in 1994 [3]. These three conditions have been linked under the umbrella term ofANCA associated vasculitis (AAV) due to their association with antibodies directed against antigens in the neutrophilcytoplasm (ANCA). All three conditions produce necrotising vasculitis of medium and small vessels with differingpredilections to various organs. Although these conditions have been recognized since the 1930's, the first clinical trial was notpublished till 1983. Fauci et al. shared their experience of using open label, uncontrolled oral cyclophosphamide andglucocorticoid combination therapy in patients with WG [4]. That paper described 85 patients recruited in one centre over 21years. 27 years later, two randomised clinical trials were published in the same week [5-6]. Between the two, the papersdescribed 245 patients with WG or MPA recruited over 4 years and followed up for predefined durations in 17 centres acrossthe world. Compared to the first 60 years of WG, our understanding and thus our methodology of investigating potentialtherapies for these conditions has changed dramatically. In the last decade there have been 12 randomised controlled trials inpatients with AAV (Table 1).It has taken a huge amount of co-ordinated effort to overcome the challenges of studying these relatively rare conditions. Tillthe Chapel Hill Consensus conference (CHCC), MPA had not been formally defined, although its existence distinct frompolyarteritis nodosa (PAN) had been recognised [3]. Prior to the CHCC definitions it was common to club together MPA andeven CSS under the umbrella of 'PAN'. Although these definitions are not diagnostic, they have been of value in identifyinghomogenous populations for clinical trials. This in turn led to the recognition that the different AAV may have different clinicaloutcomes [7].The first clinical trials in AAV were single centre studies. This often meant that the studies were either underpowered, took along time to recruit adequate numbers of patients, or mixed the differing vasculitis syndromes. All of these problems oftenmade the data difficult to interpret. This problem brought together vasculitis researchers to form research groups. The FrenchVasculitis Group (FVSG), the European Vasculitis Study Group (EUVAS) and the American Vasculitis Clinical ResearchConsortium (VCRC) were born out of efforts to conduct meaningful vasculitis research. Of the 12 RCT's conducted in the lastdecade (Table 1), 10 have been from these three groups.After the discovery of ANCA, there was hope that this could perhaps serve as a biomarker for activity in patients with AAV.Initial studies suggested that treating patients according to ANCA levels prevented relapse [8], but the present generalconsensus does not support treatment changes based on serial ANCA monitoring alone [9]. In the absence of valid biomarkers,the invention of structured clinical examination and monitoring has become the accepted surrogate for disease activity. Variousclinical tools have been used to measure disease activity, but the one that has been accepted as consensus has been theBirmingham Vasculitis Activity Score (BVAS) [10]. Of the 12 RCT's in the past decade, 9 have used different versions of theBVAS as the outcome measure, and the other 3 applied the BVAS retrospectively as they had started recruiting patients prior tothe validation of the first version of BVAS. The use of a single validated clinical tool to measure disease activity in all theclinical trials has made it possible to compare outcomes from different clinical trials...............
Systemic Vasculitis: An Epidemiological Perspective by Richard A. Watts (388-393).
The aetiology of the systemic vasculitides is unknown, clues to the causation may be revealed by theirepidemiology. The epidemiology of vasculitis poses considerable challenges to epidemiologists. These challengesinclude the difficulty of defining a case with a lack of clear distinction between the different disorders, case capture andcase ascertainment. The vasculitides are generally rare and therefore a large population is required to accurately determineincidence and prevalence, and this poses questions of feasibility. Nonetheless, despite these difficulties a considerablebody of data on the epidemiology of the vasculitides has developed over the past 30 years with interesting age, geographicand ethnic tropisms gradually being revealed. Most of the data comes from Caucasian populations of European descent. Inthis article we describe the epidemiology of systemic vasculitis focusing on possible risk factors such as age, ethnicity,infection, drugs and other possible environmental agents.
The Need for Diagnostic Criteria in Systemic Vasculitis by Ravi Suppiah, Joanna Robson, Neil Basu, Raashid Luqmani (394-401).
There are currently no diagnostic criteria for the systemic vasculitides. Due to the heterogeneous and nonspecific manner that vasculitis can present there is often a delay in diagnosis which translates to increase morbidity andmortality. The current disease definitions and classification criteria are often misapplied as diagnostic criteria, butevaluation of this has shown that they do not perform satisfactorily for this purpose. We discuss the CHCC definitions, theACR classification criteria and the EMEA algorithm which is needed to bridge the inconsistency between the two. Wealso evaluate the FVSG proposal for polyarteritis nodosa, and attempts of the Behcet's disease community to developdiagnostic criteria. We provide a brief summary of how a diagnosis of vasculitis is currently made, describe howincreased understanding of disease mechanisms has identified biomarkers which aid diagnosis, and describe howclinically applicable diagnostic criteria could be developed.
FDG-PET Imaging in Large Vessel Vasculitis and Polymyalgia Rheumatica: A Personal View by Daniel Blockmans (402-406).
Positron emission tomography is a valuable aid in the diagnosis of atypical cases of giant cell arteritis,Takayasu arteritis and polymyalgia rheumatica. It has broadened our knowledge on the vascular involvement in thesedisorders and has thrown new light on the relationship of giant cell arteritis and polymyalgia rheumatica.
Autoantibodies as Biomarkers for ANCA-Associated Vasculitides by Cees G.M. Kallenberg (407-414).
Both PR3-ANCA and MPO-ANCA are highly sensitive and specific markers for the ANCA-associatedvasculitides (AAV), in particular granulomatosis with polyangiitis and microscopic polyangiitis. This close associationsuggests a pathogenic role of the autoantibodies. In vitro and in vivo experimental data strongly support such a role,particularly for MPO-ANCA. As pathogenic autoantibodies ANCA could serve as biomarkers for AAV. Longitudinalobservations indeed prove that MPO-ANCA could serve as a biomarker for AAV although being not perfect. For PR3-ANCA, data are less convincing as some studies found a fair correlation between changes in levels of PR3-ANCA anddisease activity of the AAV, but others found not. This could be due to methodological shortcomings but also to inherentdifferences in pathogenicity between MPO-ANCA and PR3-ANCA. More studies are needed to solve this question.
B Cell Depletion in Systemic Vasculitis by Rona M. Smith, David R.W. Jayne (415-422).
The important role of B cells in the pathogenesis of systemic vasculitis has become increasingly clear overrecent years. B cell directed therapies offer an exciting new approach to the treatment of these conditions, in which therehas been little change in the options available to managing clinicians since the advent of traditional immunosuppressivetherapy. The introduction of conventional immunosuppression has transformed survival in systemic vasculitis, particularlyANCA-associated vasculitis, but at the expense of significant toxicity, and with suboptimal efficacy. B cell therapies offerthe possibility of targeted, individually tailored immunotherapy, which by improving efficacy, and reducing toxicity willimprove clinical outcomes in systemic vasculitis. However, the heterogeneity of vasculitic syndromes suggests that oneagent is unlikely to be effective in all situations. The precise indications and optimal combination of B cell directed withother therapies will need to be determined.
Anti-Tumor Necrosis Factor Blocking Agents in the Treatment of Systemic Vasculitis by Marzouq Qubti, Philip Seo (423-428).
The primary systemic vasculitides are idiopathic disorders characterized by the inflammatory destruction ofblood vessel walls. Many of these disorders are treated with high-dose glucocorticoids and cytotoxic agents which, whileeffective, are associated with substantial morbidity, particularly for patients who experience recurrent flares requiringchronic therapy. Therefore, attention has turned towards biologic therapies that abrogate specific elements in theinflammatory cascade. Tumor necrosis factor-.. is a cytokine that is central to systemic inflammation in many diseases.This article will review the role played by tumor necrosis factor-.. in the pathogenesis of systemic vasculitis, and attemptto define a role for blockade of tumor necrosis factor-.. in the treatment of patients with these diseases.
Management of Antineutrophil Cytoplasmic Antibody Associated Vasculitis by Elena Nikiphorou, Chetan Mukhtyar (429-434).
Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CSS) aregrouped together under the term 'Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis' (AAV). Recently,the British Society for Rheumatology and the European League Against Rheumatism have individually publishedrecommendations on the management of AAV. This paper reviews the two recommendations, and the recent advances inthe management of AAV. Pattern recognition and clinical suspicion remains the cornerstone for an early diagnosis. Thecombination of cyclophosphamide and glucocorticoid is the standard of therapy for remission induction. Patients with lesssevere disease can be treated effectively with less toxic therapies. There is almost no reason to routinely continue usingcyclophosphamide beyond 6 months. Long-term remission maintenance is possible with a variety of immunomodulatingagents. With increasing survival, the recognition and management of complications like cardiovascular disease, renalfailure, malignancy requires long-term follow up and regular screening.
Treatment of Large Vessel Vasculitis by Marco A. Alba, Georgina Espigol-Frigole, Montserrat Butjosa, Sergio Prieto-Gonzalez, Ana Garcia-Martinez, Jose Hernandez-Rodriguez, Maria C. Cid (435-442).
Giant-cell arteritis (GCA) and Takayasu's arteritis (TAK) are chronic and relapsing inflammatory diseasesinvolving large and medium sized arteries. While symptoms derived from large-vessel involvement characterize TAKclinical presentation, cranial symptoms and complications usually dominate the clinical picture of GCA. However,delayed consequences of large-artery involvement are being increasingly recognized. Glucocorticoids are the mainstay oftreatment for both conditions but flares and relapses are common when glucocorticoids are tapered or discontinued andadverse effects are frequent. Methotrexate has shown modest efficacy as glucocorticoid-sparing agent in GCA whereasinfliximab did not demonstrate benefit in a randomized clinical trial. Adjuvant treatment for TAK is only supported byopen-label trials and observational studies and small series, and methotrexate is the most widely used immunosuppressiveagent. Infliximab shows promise for refractory/relapsing TAK as supported by an open label study with long-term followup. Abatacept is currently being tested for both diseases in a randomized controlled trial. Other investigational agents inthe horizon such as rituximab and tocilizumab have been anecdotally used but their efficacy needs to be confirmed.Revascularization procedures, mainly angioplasty, play a crucial role in the management of patients with TAK.
Virus-Associated Vasculitides by Christian Pagnoux, David Saadoun (443-451).
Several viruses have been suspected of causing or triggering vasculitis, with hepatitis B virus-relatedpolyarteritis nodosa (HBV-PAN) and hepatitis C virus-related mixed cryoglobulinemic vasculitis (HCV-MCV) having thebest demonstrated and confident proof for a causal link with viruses. Human immunodeficiency virus, erythrovirus B19,cytomegalovirus, varicella-zoster virus or human T-cell lymphotropic virus-1 can also induce mainly localized vasculitis.Conversely, no strong evidence indicates that viruses are implicated in the pathogenesis of other primary systemicvasculitides, like Kawasaki or Behcet's diseases, or granulomatosis with polyangiitis (Wegener's). Treatment for all thesevirus-associated vasculitides should be two-pronged: one to control and clear the viral infection, using antiviral drugs; theother to rapidly control the clinical manifestations of vasculitis. Management of this second concomitant therapy is moredelicate. It can rely on plasma exchange to clear immune complexes in HBV-PAN or rituximab in HCV-MCV, butsometimes it must include short durations of corticosteroids, and cytotoxic agents for most severe cases, both of which arepotentially deleterious because they can hamper virus clearance and delay seroconversion.
Recent Advances in Understanding and Management of Chronic Granulomatous Disease by Theresa S. Cole, Andrew J. Cant, Andrew R. Gennery (452-459).
Chronic Granulomatous Disease (CGD) is a rare inherited primary immunodeficiency, characterized byrecurrent bacterial and fungal infection. The outlook for patients with CGD has improved since it was first recognized inthe 1950s but individuals still suffer significant morbidity and reduced life expectancy.Recent developments clarifying the role of neutrophil granule proteases and neutrophil extracellular traps in microorganismkilling have contributed to our understanding of the susceptibility of CGD patients to infection. There have beendevelopments in our understanding of the inflammatory component of CGD, in particular the similarities between CGDbowel disease and Crohn's disease. There have been advances in treatment, in particular new antifungal agents. Largeepidemiological studies have highlighted the many problems CGD patients suffer. With improved survival inflammatorycomplications of CGD have become more problematic, particularly gastro-intestinal disease. Poor growth is common.There have also been concerns about cognitive deficits in those with CGD.Hematopoeitic stem cell transplant provides complete cure and gene therapy holds hope for the future despite its currentlimitations. However, these curative measures are not without risk and families are often left with a dilemma regardingwhether to opt for curative measures or remain on conservative management.


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The Jakarta Post
The critically-endangered Sumatran tiger (Panthera tigris sumatrae) population in Way Kambas National Park (TNWK) has declined past recent estimates as a result of poaching and the destruction of wildlife habitats.
The latest data issued by the TNWK in Lampung this month showed that the number of Sumatran tigers in the park has dwindled to the brink of extinction.
Coordinator of the Sumatran Tiger Rescue and Conservation Foundation (PKHS) Sumianto said the current number of tigers found in the 125,000-hectare national park was estimated at less than 30.
He added that in 2000 the population was estimated at 36 to 40 tigers.
"We monitored their number through camera traps in 2010 and estimated that there were around 30 tigers, a decrease compared to 2000," Sumianto said on Monday.
According to Sumianto, the biggest threats against Sumatran tigers in TNWK are poaching and deforestation.
"The population of the Sumatran tiger has continued to decline, as their reproduction rate is very slow.
They may become extinct in TNWK if there are no serious efforts made by the government to preserve the forest and stop poachers," he said.
"The gestation period of a Sumatran tiger is 20 months, but that's still no guarantee, because tigers are regarded as less prolific in terms of breeding," he added.
In 2007, the Lampung Forestry Office, TNWK and Bukit Barisan National Park (TNBBS) expressed high hopes of increasing the number of Sumatran tigers, thanks to the drop in poaching between 2004
and 2007. However, they could not show the latest valid data on the Sumatran tiger populations at TNWK and TNBBS.
In 2003, TNBBS rangers discovered 13 cases of tiger poaching. The number of cases dropped to nine in 2004 and only one case was recorded in 2005. Prior to 2002, tiger poaching was alarmingly prevalent.
TNWK and TNBBS attributed the drop in the number of poaching cases to hard work by those protecting the forest.
No cases of Sumatran tiger poaching in Lampung were reported between 2004 and 2011. However, that doesn't mean that animal poaching has stopped, as Sumatran tigers still exist in the parks.
Poachers and animal traders are still present near TNBBS as well. Besides that, Lampung is known as a source in the illegal wildlife trade among Java, Bali and South Sumatra. Many poachers' traps can still be found in TNWK.


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Longtime Pirates color commentator Bob Walk generally brings a just-me-being-me, low-key approach to his work.
And two decades into his radio and TV career that approach makes Walk good. In a world of endless sabermetrics, Walk just talks baseball. He's not worried about the latest statistics or on-paper measurables.
Instead he connects with fans by talking about the game, watching what happens and then drawing on his 13-year playing career and offering some sort of explanation or opinion.
"It seems like all the stadiums these days have stats up on the scoreboard right in front of us," Walk said. "Or, I might have a computer with the Gamecast. There's no reason for me to write things down."
So Walk just talks - and it works.
At 4:40 p.m. June 11, he walked into the PNC Park press box, wearing a shirt and tie and carrying his suit coat. With the first pitch by No. 1 draft pick Gerrit Cole fast approaching, Walk was ready. He'd been talking about Cole most of the day anyway.
"I needed a new faucet handle, went to Home Depot, and the guy there was asking me what I thought about Cole, how he'd do," Walk said. "I told him we'd wait and see, and even if he did great it was only one game. Or, if it did poorly, it was only one game."
Walk watches for things fans cannot see or might not know to make broadcasts better. In the case of another Pirates pitcher, Jeff Locke, Walk said body language tells the story. He sees much more confidence in Locke's demeanor than when he made his debut in 2011.
Walk knows his job as an analyst is not a place for measurables, either. As a result, he's comfortable talking about what he hears and sees - without concern about what others think of his work.
"It's not like you can point to a 2.80 ERA and know you're doing a good job. If you listen to what people have to say and worry about it, it can be paralyzing," Walk said. "So you just do your job and not worry about it."
'Scrap' sounds
Longtime Penn State assistant football coach Tom "Scrap" Bradley, who led the Nittany Lions on an interim basis for four games after the Sandusky scandal first broke in 2011, visited with hosts Jack Arute and Gino Torretta on "College Football Playbook" earlier this month.
Arute, formerly a longtime sideline reporter for ABC Sports, and Torretta, a Heisman Trophy-winning QB for Miami, made the segment - which focused on on-field issues as opposed to anything related to the scandal - enjoyable and engaging, although the familiarity of all three with each other let it become more of a backslapping yuk-fest than anything productive at times.
Tuner tidbits
n Bradley, who did analysis on Pittsburgh Steelers radio last season, lost a possible TV college football analysis job last year because of the scandal - or at least because of its timing. He was set to work Conference USA games for CBS Sports Network, but media day for the conference fell the day after the NCAA announced its sanctions against Penn State in July 2012, and Bradley then did not attend media days and the job never materialized.
n Nik Wallenda's walk across the Grand Canyon last week drew more than 10 million viewers to Discovery Channel. For some stick-and-ball purists, it might not be sport, but those type of 1970s-style daredevil things always draw my attention.
n Tennis fans probably like it, but ESPN's abundant Wimbledon coverage just messes with my morning by bouncing "Mike & Mike" of ESPN2.
Steve Sampsell covers the broadcast side of sports. He's on Twitter @talkingtvsports, writes at www.talkingtvsports.com online, and may be contacted at firstname.lastname@example.com with comments.


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It's a college movie. No, it's a boot-camp movie. Wait, it's both. Annapolis takes place at the U.S. Naval Academy (commonly called Annapolis) in Maryland, one of the five American institutions of higher education for kids who just can't seem to make up their mind whether to join the armed forces or attend university following high school. Well, that is putting it rather simply. Like the U.S. Military Academy (West Point), the U.S. Air Force Academy, the U.S. Merchant Marine Academy and the U.S. Coast Guard Academy, Annapolis preps its students to become officers in its respective branch of the military in addition to awarding them bachelor degrees. It doesn't charge tuition — in fact it pays those enrolled a weekly salary — but the Naval Academy is one or the toughest schools to get into, and it is even tougher to remain in.
This doesn't stop Jake Huard (James Franco), one of the incoming freshman, or plebes, in Annapolis' class of 2008.
He manages to be admitted despite his lack of good grades. I assume he also falls short in the areas of SAT and ACT
scores, leadership experience and any number of other expectations the school is likely to have of its applicants. What
he does have is a dream, which he's had since he first laid eyes on the campus from his home across the river, as
well as a nomination from a congressman — a requirement, not a guarantee, for acceptance. Oh, and he likes
to box.
Well, as it turns out, nothing in Annapolis really elevates the challenges of Jake's goal to win the year-end Brigade championship match, and it fails any prospects for mixing the genres. Huard's transition form amateur boxer to underdog favorite looks like a piece of cake, and getting through the first year of the Naval Academy's intense program seems a mere bother along the way. It will be interesting to see if the Naval Academy sees an increase in applicants this year based on its portrayal in the film, which never does justice to the school's magnitude.
By focusing almost completely on Jake's athletic endeavor, the film gets its conflict confused. Jake's main desire is constantly addressed as the ability to make it through Annapolis. From photographs of him as a boy in a sailor outfit to his continued acknowledgement of a promise made to his late mother, all signs point to a narrative intention that isn't actually followed. Everything in the picture hangs on Jake's boxing. The higher-ranking cadet he likes (Jordana Brewster) winds up being an expert coach. The proud upperclassman (Tyrese Gibson) who poses a threat to the progression of Jake's enrollment is more importantly his adversary in the ring. In fact, nearly every cadet seems involved in intramural boxing. You'd think there aren't any other sports going on at Annapolis, let alone any other activities, at all.
Adding to the false sense of easily attainment into Annapolis is an assortment of ragtag students that I find hard to believe would even desire enrollment, let alone achieve it. Huard's roommates alone include a sleazy, puerile smart-ass (Wilmer Calderon) and a very overweight, small town softy (Vicellous Shannon). While not impossible, there is a certain unlikelihood of the latter passing the school's fitness requirements. Then, there is Loo (Roger Fan), the fourth in their room and the only convincing plebe in the whole cast. Disciplined, honor system obedient, and overachieving, he represents the best of the best you'd expect to find in the academy, and should expect to see filling out the supporting roles. Unfortunately, that wouldn't make for a colorful palette of characters. Besides, every boot camp movie needs that fat body that can't make it up the wall in the obstacle course.
It is this strict discipline to maintain genre traditions that keeps Annapolis from being completely unacceptable. Such conformity of genre basics makes the story correlative to the themes of the military. With any straying from the conventions, the movie may well have taken place anywhere. It could have been about a Boston kid looking across the Charles at MIT or Harvard. But it is orderly, and therefore best suited to the atmosphere of a military academy. Of course, I would rather see it take place in West Point, where at least the Hudson Valley provides for beautiful scenery to look at. Sure, it would make less sense for Huart to grow up across the river from that academy, but I'm biased, having been raised on the athletic rivalry of Army vs. Navy, always rooting for the West Point's Black Knights over Annapolis' Midshipmen.
Anyway, the traditions (or clichés) maintained in Annapolis actually resemble those of the Police Academy series — sans comedy — more than any boot camp army films. At times, there appears an improbable mission within the school's ranks to see the plebes fail. I could be wrong, but I imagine the school's aim is to lead its students to greatness, not drive them to defeat. Plus, one weasily, over demanding underling (McCaleb Burnett) is so reminiscent of Scott Thomson's servile troublemaker character from Police Academy that someone must have intentionally cast a look-alike for the part.
For all the things that Annapolis is and isn't, the most disappointing thing it isn't, is an action movie. Aside from the fact that any sort of action sequence, well-done or not, would make it a more commercial sell to a mainstream audience, and aside from the fact that most critics, myself included, could have done with a bit of excitement to distract from the mundane script, the marketing for the movie all but promises that there is action to be seen. The trailers and commercials include footage of ships at sea and jets in the air, possibly borrowed from a Navy recruitment video, mysteriously absent from the actual movie. And, I'm pretty sure that I saw an explosion of some kind in the trailer that didn't make it in either. So, by this misleading campaign, one might expect the film to follow Jake through his four years and onward, into some kind of combat finale in which he displays the skills learned at the Academy. I sure did.


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Hi Katlyn Durocher,
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Then, Lucuma powder is also rich in antioxidants and has many beneficial properties including, high levels of carotene, fibre, vitamins, minerals vitamin B3, and other B vitamins. It is well known for its sweet maple flavour and low sugar content.
To sum up, I use these both fruits in many dishes and foods such as cakes, ice creams, drinks, shakes, baked goods and many others.
As for me, I buy all my products there: Maretai Organics
They offer high-quality products at the best price!
I hope to have answered you question!


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Carroll College's Strategic Plan, Vision 2018, includes a group of distinct, complementary initiatives that will advance the college's mission and vision. Organized into eight key areas critical to Carroll's continuing achievement, these initiatives focus on the college's Vision and Enduring Commitments. These elements are listed below, as well as the process used to created the strategic plan. Detailed outcomes for each initiative can be found on the Strategic Action Plan page.
Carroll College will enhance its nationally recognized status for excellence by preparing students for vocation and enlightenment in an increasingly GLOBAL and DIGITAL age with dynamic and distinguishing academic and co-curricular programs. As a diocesan Catholic college inspired by FAITH, Carroll will further integrate liberal arts, professional studies and service to others. Carroll will nurture leaders to live fully in the present and prepare for the future while engaged in their LOCAL community.
To realize its Vision, Carroll College must rise to the occasion of these four Enduring Commitments:
Carroll will develop programs that encourage all community members to participate in the formation of the whole person – mind, body and spirit. Carroll will faithfully engage the intellectual tradition and the teachings of the Catholic Church, which are the source of its identity and mission. Carroll will therefore provide the following:
I. Campus-wide awareness of and understanding of Carroll College's history, its Catholic mission and its relationship with the Diocese of Helena
II. A community of faith and reason that engages with the Catholic intellectual tradition and explores its contemporary relevance
III. Opportunities for growth in faith and formation in Gospel values through programs that contribute to the full realization of a dual goal of vocation and enlightenment
IV. A culture of service that integrates the principles of Catholic social teaching and promotes civic engagement
V. A culture of authentic interfaith dialogue, civil discourse and cooperation that recognizes what is true, good and beautiful in all traditions
VI. Spaces and opportunities for worship, reflection, inquiry and leadership that foster a sacramental vision of community and its responsibility for God's creation
Carroll will engage with the people and environments of Helena and Montana to both enhance students' wellbeing through a deep connection to their environment and also to enable faculty, staff, students and alumni to contribute their intellectual capital and skills to the identified needs of the larger community. The college will therefore support the following:
I. Students, faculty and staff engaged in service activities
II. Programs that provide experiential learning through Montana's unique landscape and Helena's location as state capital
III. Relationships with business, government, organizations, educational institutions and communities that further student career opportunities and college relations
IV. Efforts to enhance its reputation as a regional resource for scholarly thought
Carroll will prepare students to navigate in an increasingly complex and interdependent world with agency and confidence. The college will create the following:
I. Distinctive programs on at least three other continents
II. A campus with an international community of students, faculty and staff
III. Relationships with global peers using technology to further opportunities in language study, teaching, research and other subject areas
IV. Enhanced academic and co-curricular programs that reflect global perspectives
Carroll will provide technology to enhance teaching and learning opportunities. It will therefore develop the following:
I. Technology-enabled classrooms to increase interaction and encourage collaborative learning
II. Multimedia capabilities to connect the world's teachers and learners
III. Digital workflows to improve efficiencies
Carroll will develop new academic and co-curricular programs that blend service learning, technology and ethics in response to the changing world. Carroll will strengthen its excellent academic and co-curricular programs by creating the following:
I. An environment that is conducive to an interdisciplinary approach to academic programs, fully integrating liberal arts, professional and pre-professional programs that will include
II. Masters, 3 2, and 4 1 degree programs that are mission-focused and market-driven
III. Online/hybrid courses and programs that meet the learning needs of current students and broaden the opportunity to attract new students outside the campus
IV. Additional opportunities for undergraduate research
V. Professional accreditation status for Business, Engineering, Education and Nursing Programs
VI. New and enhanced teaching and learning facilities
Carroll will enhance the residential character of the student learning experience through an investment in programs, facilities, furnishings and technology to strengthen its sense of community. The college will provide conditions and practices that support an optimal learning and work environment for students, faculty, staff and extended community. This will be made possible by the following:
I. An enhanced residential and community space that will include
II. Integrated academic and co-curricular programs that will consist of
III. A curricular experiential component, which includes study abroad, internship, practicum, clinical, student teaching, leadership or service
IV. Technology to achieve academic, personal and organizational excellence that will establish
V. A healthy, safe, and secure work and learning environment for faculty, staff, students and visitors on campus reinforced by a comprehensive Enterprise Risk Management Program to include policies, tools, resources, training and educational opportunities
VI. The recruitment and retention of qualified faculty and staff committed to Carroll's mission and values by establishing
Carroll will have a greater impact across its region, its nation and throughout the world by educating more students. It will recruit, enroll, retain and graduate a greater number of students by creating the following:
I. Enhanced strategies that support market penetration and development, such as
II. Increased funding for endowed scholarships
III. Increased retention and graduation rates that will be achieved by
Carroll will build and strengthen its financial foundation to increase its ability to invest in academic and co-curricular programs, as well as human, technical and physical resources. It will improve financial vitality and sustainability by establishing the following:
I. Both annual and five-year capital and operating budget plans based on realistic and achievable goals that will incorporate and advance the priorities of the strategic vision.
II. Increased revenue sources and new revenue streams by creating
1. Marketing and sales strategies for ticket and event income
2. Defined policies and procedures relating to Corporate Sponsorships
III. Increased funding from individuals, foundations, and both corporate and federal sources achieved through
1. Expanded outreach to alumni, friends and parents
2. Yearly assessment of annual giving campaign
3. New strategies to increase major and planned gifts
4. Increased proposals to foundations of national prominence
5. Incentive programs that encourage faculty to develop grant proposals (funding requests > $25,000) for submission to foundations and federal agencies
IV. Institutional priorities identified for a MIND-BODY-SPIRIT campaign such as
1. A feasibility and readiness report for a MIND-BODY-SPIRIT campaign in the next five years
2. Identified endowment priorities based on feasibility and assessment of the last campaign
3. Developed MIND initiatives of the campaign
4. Developed BODY initiatives of the campaign
5. Developed SPIRIT initiatives of the campaign
V. Updated and prioritized campus master plan
At his first Board of Trustees Meeting, President Evans announced that Carroll would "embark upon a vigorous strategic planning process ... involving Cabinet, faculty, staff and trustees over the course of the next 12 months … requiring deep thinking and lots of work." The Carroll community embraced this invitation with enthusiasm, excitement, and creativity, participating in several strategic planning activities. The resulting product was a dynamic plan, Vision 2018, which charts the college's course for the next 5 years. The plan was assembled from the ideas and information collected at the following activities:


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Fundraising and Support Staff
Wes Witemeyer • Program Analyst
firstname.lastname@example.com • (325) 674-2031
Wes Witemeyer ('92) is program analyst for the Advancement Division. He manages all reporting and data extraction, analyzes data processes and serves as a liaison and technician for all Banner Database system issues related to Advancement and Alumni Relations. Wes began his service to ACU in 1995 and began his work in Advancement in 2003.
Wes received his B.A. in youth and family ministry from ACU and his M.S. in Christian education in 1995. He is a Microsoft Certified Professional for NT 4.
He and his wife, Karen (Gaskin '93), have three children. He enjoys working with his church, playing golf and running his computer consulting business.
Give Online
Help educate students for Christian service and leadership.
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Recommend a prospective student that would ba good fit for ACU.
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DETROIT -- Jason Williams and Johan Franzen are gradually working their way back onto the ice.
Williams, out since Nov. 7 with a fractured fibula, skated for 10-15 minutes recently. Franzen, out since Oct. 8 with a torn knee ligament, has been skating lightly on his own.
"Can't push 100 percent and can't do quick turns and stops,'' Franzen said. "Taking it nice and slow, don't want to rush anything.''
Franzen still is a long away from returning (early March).
Williams hopes to be back mid-to-late January. But, before he can start skating regularly, he needs to alleviate the pain he feels when putting on his skate.
"Once I can get something in my boot where it can take the pressure off that fractured area, hopefully on this (upcoming) road trip, I can start skating, and towards the end (of the trip) start practicing with the team,'' Williams said.
"If I skate for a good week, week-and-a-half with the team and feel good and confident, I should be OK. I'm definitely going to have to skate by myself after practice, maybe even before practice, try to get my legs and my wind back. It's been a while since I used my leg in any kind of skating motion. I'm going to have to build my leg up, stamina-wise.''


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Normally, a team coming off a state championships would be the obvious pick to at least win its league the following year.
As deep as the Foothill League is in boys cross country, Golden Valley is hardly a shoe-in.
It's not as much a knock on the Grizzlies as much as it's a testament of how talented the rest of the league is, top-to-bottom.
Saugus and Hart both bring back a talented and deep group of runners and Canyon returns one of the top names in the league.
Valencia and West Ranch have added mileage and intensity to their offseason training, making the competition that much more difficult in a league with an ever-growing reputation.
Golden Valley
It took Golden Valley years to build up to its current level of prominence.
After coming so close three times in a row, it all finally culminated in a Foothill League title and a CIF Southern Section Division II and a CIF State Division II title last season for the Grizzlies.
Now, this program has a question to answer: Can it keep it going?
There are plenty of doubts, though Golden Valley has already climbed to No. 6 in the latest CIF State Division II poll, which is still below the Saugus boys at No. 5.
The fact that the Grizzlies return just two out of seven runners who competed at the state meet last year could explain the soft response for the defending state champions in the polls.
First-year head coach Marc Minasian sees it as a positive.
"When you lose five out of seven, you can easily come back and say, 'Oh man,' but these (returning) guys have been busting their tails since May and the rest of the guys have come with them," Minasian said.
Minasian inherits Golden Valley team that returns seniors Nolan Del Valle and Brendan Tinoco, who were both scoring members of last year's state championship team.
After those two, the team has a secure No. 3 runner in junior Arnold Bautista, but beyond that, it's a big group of about eight runners trying to seize the lower spots.
Seniors Rafael Estrada and Siddu Kamarsu and juniors Nicholas Devantier and Luke Contreras are among those contending to replace the froup of five stellar graduates last spring.
Though it's been a bit of a rocky start for the Indians, who have a few athletes recovering from injuries, they still have a lot of firepower remaining from last year's team which took seventh the state Division II final.
Though Hart graduated last year's strong one-two punch of Sam Peckham and Austin O'Neil, head coach Larry David is confident in another group of top-notch runners who can anchor the team this season.
Senior Billy Walker is recovering from a muscle injury in his leg, but is expected to be a key piece of the team later in the season.
Walker and fellow senior Josh Sherfey, who both ran in the state meet last year, provide a stable foundation of experience at the top for Hart.
"We look to those guys to lead this team second half of the season, then there's just a good spread of sophomore and junior support."
Two sophomore returners, Mac Kaufman and Ruben Rubira, had impressive showings at the Seaside Invitational with Rubira winning the 10th-grade race and Kaufman taking eighth.
David said he also expected contributions from two juniors who are new to varsity, Andrew Orona and Bailey James, who likely would have ran varsity last year if it weren't for an injury.
When A.J. Yarnall was a sophomore, he was part of the best Saugus boys team in school history. It was a team that won a CIF-Southern Section Division II championship and finished second in state.
Yarnall is now a senior and he's the clear top dog on another very deep, very talented team which could try to match the level of the team from two years ago.
"This team is trying to be as good as that team, CIF champions and competing for a state championship," said head coach Rene Paragas, who has given most of the coaching responsibilities for the boys varsity team to assistants Jose Flores and George Serrano.
After Yarnall, who just returned from a knee injury last week, the Centurions have senior and varsity newcomer Rodrigo Ornelas, who has rocketed to the No. 2 spot after strong performances at the Seaside Invitational and Woodbridge XC Classic earlier this month.
Paragas said both Yarnall and Ornelas are potential all-state runners.
They'll be helped out by senior Austin Fisher, junior Alex Pearson and sophomore Brian Zabilski, who provide a steady core for a Saugus team which will see contributions from a number of other talented runners.
For the second straight year, Valencia is going to have to fill in for a host of graduated seniors from the previous year.
On the bright side, the team's best two runners this season are two juniors, Alex Allevato and Nick Lentz, who both ran sub-16 minute times at the Seaside Invitational.
Allevato is a returner this year, but Lentz is new to varsity.
The Vikings are seeing a lot of new guys quickly rising in the ranks.
Another is senior Calvin Olbes, who ran the 800-meter in track for Valencia exclusively until this season.
He's catching on to the cross country game quickly.
"We knew he was going to be good," said head coach Jeff Gilkey of Olbes. "I just didn't think he was going to be that good that fast. It was one of those wonderful surprises."
Between Olbes, sophomore Ryan Davis and freshman Austin Fischer, there are no shortage of strong runners fighting for the top varsity spots.
For the last few years, Canyon has been building up depth to give support to its clear No. 1, senior Zach Wims.
Head coach Paul Broneer thinks he may finally have enough behind Wims to give the Cowboys a serious chance at contending.
"Here it is," Broneer said. "I think this is the year we have three seniors on our top seven and we have eight guys who are right there."
Senior Joel Estrada is the next runner on the totem poll behind Wims, and the Cowboys have sophomore Caleb McClain and juniors Adam Driedger and Jason Hillquist following closely behind.
Senior Dylan Haerle is also expected to be in the pack for Canyon, which has a cast of runners hoping to return the team to past prominence.
The Cowboys haven't been to a state championship meet since 2009.
"Every year, that's the goal, go to the state meet and hopefully perform well," Broneer said. "We haven't been there in a while for the boys, so they're motivated."
West Ranch
The Wildcats are hoping the past two years have been building blocks to this season.
Finally, the team has a solid senior class of runners with varsity experience.
Jeffrey Black, Pierce Miller, Ramon Gutierrez and Eugene Generoso are all returning seniors who have a chance to help the Wildcats climb out of the bottom of the league.
"We're hoping (the experience is) going to help us out," said head coach Rick Larimore. "We're tired of being in last place. We want to move up."
The Wildcats will mix in their senior-heavy lineup with a few junior newcomers in Ashton Garcia and Billy Wegeng, as well as freshmen Tucker Welker and Ryan Painter.
Together, this is a group that looks much better than the West Ranch team that finished sixth in league a year ago.


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on October 23, 2012 - 4:03 PM
A man caught on surveillance video fatally shooting his victim was sentenced to 25 years in prison Tuesday.
Taire M. Chaney, 21, was sentenced by State Supreme Court Justice Christopher J. Burns after he earlier pleaded guilty to first-degree manslaughter.
Chaney admitted shooting Anthony L. Pitts, 20, in the head on March 2 following an altercation inside Pandora's Sports Bar at Fillmore and Victoria avenues.
It was later revealed that a city surveillance camera, located on a utility pole more than two blocks away, helped lead Buffalo police detectives to Chaney.


text:
By JOHN PAUL CULOTTA,
This summer, all of us are worried about the state of our nation's economic situation. Many of us foresee deficits as a threat to our future.
At the same time, we and most of globe suffer from a sluggish economy and poor employment prospects for many. Millions are finding it a burden to meet primary economic obligations. Cities and states in this nation cannot reconcile the needs of their citizens with budget restraints. The list of economic problems appears endless.
This nation has faced worse economic times in the past, but this economic depression is unique because the nation is still fighting major wars overseas and military expenditure is the root of our deficits — not social spending or entitlement programs.
We need to examine our entire budgetary expenditures including the military, the reckless reliance of financial institutions to master our fates, and the disregard of the human suffering social spending cuts inflicts. Our economy should work for us not for the wall street titans.


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Captain Paul Collingwood is missing for Durham Dynamos' Friends Life t20 game with Leicestershire Foxes at Grace Road this evening due to a thumb laceration.
The former England all-rounder suffered the injury in Sunday's FLt20 victory over Yorkshire Vikings and is also set to miss tomorrow's match at home to Notts Outlaws. He is hoping to play in the LV= County Championship meeting with Derbyshire, which starts on Monday. Yorkshire Bank 40 skipper Mark Stoneman will make his debut as Twenty20 captain in Collingwood's absence.
Seamer Graham Onions is unavailable to Durham in one of eight FLt20 fixtures today, like the other members of the England squad that faced Essex this week in the LV= Challenge.
Leicestershire, who are bottom of the North Group, are missing Ireland's Niall O'Brien to international duty today and for their next two FLt20 contests, in which Ned Eckersley is therefore due to keep wicket. Seamer Robbie Williams, who bowled well in defeat to Derbyshire Falcons on Saturday, is injured but Rob Taylor returns from Scotland duty.
One 100 per cent record will go when leaders Derbyshire meet second-placed Notts at the County Ground in one of four sell-outs today along with the games at Headingley, the Kia Oval and Taunton. The Falcons have won thrice and their visitors twice.
Yorkshire have former Australia batsman Phil Jaques available after an abdominal strain for the Roses clash with Lancashire Lightning. Arron Lilley comes into the Lancashire squad in place of fellow spinner Simon Kerrigan, who is attending a family member's funeral.
South Group front-runners Surrey are without Gary Wilson for the visit of nearest challengers Middlesex Panthers, for whom fellow Ireland internationals Paul Stirling and Tim Murtagh are also absent. John Simpson takes the squad place of Stirling, who unlike Murtagh played in yesterday's victory against Essex Eagles.
Essex must again make do without Tom Westley (broken finger), David Masters (Achilles) and Tymal Mills (hamstring) as they take on Kent Spitfires at Canterbury where both sides will be seeking their first FLt20 triumphs on 2013.
Holders Hampshire Royals have named an unchanged squad for their trip to Sussex Sharks at the BrightonandHoveJobs.com County Ground. Sussex are without Ireland's Ed Joyce, although he rarely represents the Sharks in the shortest format.
In the Midlands, Wales & West Group Northants Steelbacks hope to welcome back Steven Crook from injury, although he will not be risked if still a doubt, while Kyle Coetzer and David Murphy return from Scotland duty. Northants host Warwickshire Bears, who are missing Ireland captain Will Porterfield.
Somerset, without Ireland's George Dockrell and Nick Compton who is guesting for Worcestershire versus Australia, start their FLt20 campaign with the visit of Gloucestershire Gladiators. Alviro Petersen is set to play in Somerset's first three games before joining South Africa's squad to tour Sri Lanka.


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Mabz's complete guide to ownage for Knight Davion
Knight Davion is a powerful warrior who calls upon his draconic heritage to augment his already fearsome combat abilities. He has two powerful offensive skills: Dragon Tail and Breathe Fire. Dragon Tail allows him to stun a single enemy target for several seconds, and Breathe Fire taps into his inner dragon to unleash a powerful area of effect attack. This potent offense is supported by Davion's Dragon Blood passive skill, which makes him extremely difficult to kill by boosting his armor and hit point regeneration significantly. Combined together, these abilities make the Dragon Knight a tough, versatile fighter. At higher levels, the Dragon Knight gains the ability to transform completely into dragon form. The abilities and strength of the dragon form increase with levels. At maximum level, Davion transforms into a mighty blue dragon with an area of effect cold attack, which drastically slows all enemies caught in the freezing blasts. Along with his natural combat skills and toughness, this makes him an extremely dangerous foe.
Alt+tab mini guide
1.Breathe of fire
2.Dragon blood
3.Breathe of fire
4.Dragon tail
5.Breathe of fire
6.Elder dragon form
7.Breathe of fire
8.Dragon blood
9.Dragon blood
10.Dragon blood
11.Elder dragon form
12.Dragon tail
13.Dragon tail
14.Dragon tail
16.Elder dragon form
Startup with
Role of DK
DK is a very flexible hero who can be a carry,tanker hell even a roamer but he mostly shines on the 1st one because has good armor and when farmer real well can be a huge pain in the ass
Pros (+)
-GOod lane control with breathe of fire
-Tanky coz of dragon blood
-Lane control again and pushing capabilities cuz of lvl 1 dragon form
-Flexibility in roles
Cons (-)
-Needs decent farm to look good mid-early game
-Mana but can be solved with bottle
-Lack of mobility
Breathe Fire
Breathes fire at enemy units, dealing damage.
This is your main farming and harassing and maybe for fun kill stealing
Dragon Tail
Davion bashes a melee-range enemy target with the fury of a dragon's tail swipe. Stuns the target and deals minor damage.
Your primary disable which is very helpful even at level 1
Dragon Blood
Grants Dragon Knight blood from his ancient ancestral dragon heritage, which increases health regeneration and armor
Your ability which makes you tanky with armor and hp regen
Elder Dragon Form
Transforms the Dragon Knight into a powerful elder dragon.
This skill makes DK very strong turning into a range dragon with different passive orbs
note:Even with these orbs you can still stack an orb with it because it isn't consideren an orb
Skil build
1.Dragon Tail
2.Breathe of Fire
3.Breathe of Fire
4.Dragon Blood
5.Breathe of fire
6.Elder dragon form
7.Breathe of fire
8.Dragon blood
9.Dragon blood
10.Dragon blood
11.Elder dragon form/Dragon Tail
12.Dragon tail/Elder Dragon Form
13.Dragon tail
14.Dragon tail
16.Elder dragon form
Startup with
With this items it give you solid start because of the balance stats it gives after these rush bottle and a bracer and if needed a wand.
Empty bottle
When playing DK solo mid having a bottle is a must because you need to spam breathe of fire in order to be effective in lane and it is better to go bottle+crow rather than taking runes because it makes you lose exp and gold
It gives you what every carry needs stats,ASPD and MS and if you need more mana you could always change it into int treads
They make look cheap but they do good it gives you nice stats specially str and instead of getting a vanguard just get 2 bracers.
Lothars Edge
If you are able to get this early then this would make you a beast.Whoever said that "You aren't supposed to be a ninja. You are supposed to tell your opponents 'ATTACK ME DAMMIT' and draw the fire away from your teammates" should die right now.It is used for bonus DPS and escape not to forget bonus crit which splashes in dragon form
Black King Bar
It provides hp and some bonus damage and being immune to magic makes DK a great tank/carry and living longer in clashes means more damage output.
Special Mention
This item can be good on DK especially if he has Bottle And treads because you can use breathe fire more times without consuming too much of your bottle if you can master the trick even I haven't mastered it yet only player I've seen it done was KuroKy with SF.
Because of the high damage you get from lothars and bkb then getting buriza would be your best bet because you can get a high crit damage with DK eating paper heroes alive.
It's the perfect orb for DK considering his high damage life leech would prove very useful in teamfights plus the bonus str is nice for extra tankiness.
Divine Rapier
Once you already get your core build up getting a DR can be a good choice considering you're already tanky enough to surive with BKB and can escape with your lothars edge
Heart of Tarrasque
If things aren't going your way too much and the enemies are well farmed then getting heart will prove useful so you can tank more damage from the enemies.
Assault Cuirass
The ASPD and Armor aura from Assault will be very helpful for your teammates in pushing and the armor degen for enemies will really suck for them.
Hood of Defiance
IMO this item is very situational since part of your core is a BKB but if in early game those nukers really manage to shut you down then getting hood is a valid choice.
Blade Mail
Sick of that troll/void permabashing you?Or those 1k crits from mort annoying you?Then BM is your item.
Mask of Madness
I highly disrecommend this item because you get softer when you activate rage but the burst DPS you get from the bonus ASPD you get is not to be taken for granted coupled with armlet it is great.
Armlet of Mordiggan
This is a very good item for DK considering he is str plus he benefits mainly from the bonus damage+str.IMO you should only buy Armlet when you already have a lifesteal like MoM which synergizes very well with armlet.
Rejected Stuff
Battle Fury
This is the most common noobish thing I see on garena.Sure its good for farming DPS and hp/mana regen but it really sucks.You can get hp/mana and farming capabilities from your bottle.And the cleave you want?Then why bother using elder dragon form
Arcane ring
I once had a teammate who used arcane for DK isn't that very stupid?He said it's used for fire breathe spamming well cd isn't that short for spamming and bottle is sufficient for that case.
It really isn't a good choice for the price and bonuses id rather get 2 bracers which is cheaper and has good results
Sange and Yasha
Really this is dumb is level 3 dragon frost not enough for you?
After getting some items (never start with a bottle without a courier its for noob pubbers only)You'll pretty much need the solo mid lane even if there is a sf or tinker because DK will lose effectiveness early game if not solo.Just follow these easy steps to own yourlane
1.Use fire breathe as much as possible when a creeps is red use it just make sure you hit the hero too.
2.I suggets use bottle+crow rather than runewhore because it saves you exp+gold its simple place your bottle in the crow then E+SHIFT+T+SHIFT+R
3.Spam your ulti because it really gives you an advantage inlane.
4.Farm up your core items and go killing
5.Pick up some luxury items and go own the game
Mentionable Allies And Foes
They really help you in a big way early game killing your enemy in lane will provide you a few seconds of free farm which is very nice for you.
Mid game they are your best friends because of their nice disables and DPS you can easily dispatch heroes.
Clashers/AoE disablers
Because of DK's AoE splash attacks having him in a clash makes cleaning up faster
Special Mention
Vacuum will make your enemies cluster in an area thus making them food for DK so DK splash attacks+Dark seer+ any AoE disable like ravage or blackhole will mean trouble for enemies
Orb Walkers
They make Early Game hell for you
Because of your tanky nature owning you is a walk in the park for these guys
Armor Debuffers
WIth their armor debuffs they can still own you even if you're tanky
This game shows how DK owns in lane with bottle+crow strat
This what I meant when i Said DK is flexible in this game DK is played as a roamer wherein he still manages to farm a bit mid game.
Final words
I hope everyone who's reading this guide had fun and learned a bit from it and to all haters no problem I'm not perfect I would like to thank ArtiQ for his raijin guide because I copied the layout of the guide thanks and sorry man.
And of course Icefrog for bringing us a very wonderful game
5/19/2010 added Armlet and Mask of Madness to situationals/optionals
5/20/2010 Due to populer demand lvl 1 changed to dragon tail
Knight Davion the Dragon Knight
Author: MAbZ
Map Vers.: 6.67c
Mabz's guide to Dragon Knight
DK ownage
Last Comment:13/06/2014
Total Votes: 112
Current Rating: 2.89
Views: 109519


text:
The Penguins did everything they needed to do in this game. They didn't get great goaltending from Tomas Vokoun, but they got timely goaltending with Vokoun making two huge saves late in the second period.
Crosby scored three goals, Brenden Morrow gets credit with the game winner. The Pens are now up 2-0 in the series as it shifts to Ottawa on Sunday night at 7:30.
Recap later. If you missed them here are the gifs of Crosby's first and third goals.


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Idiotic youtube commenter.
Youtube comment:"DEATH to all Emos, get a life or get laid attention seeking fucks". See this guy is a gink.
dodane przez little emo marzec 19, 2008
Trending Now
Can you define these popular missing words?
Top Definition
a racial slur used to describe someone of Indian descent
All the damn ginks are making this place smell like fucking curry.
dodane przez couldbeacrackhead kwiecień 16, 2009
An undefined word that people on the urban dictionary aimlessly define and that Saints Row IV used for some unforeseen reason. No one actually knows the definition of gink so people come up with random definitions that are suitable to urban dictionary and the wide variety of definitions leave anyone who looks this word up wondering what on earth a gink is :/
Tod: Wtf is a gink
Billy: Wtf, idk go look it up on urban dictionary
*2 min later*
Tod: Wtf is a gink?
Billy: Wtf, idk go look it up on urban dictionary
*2 min later*
Tod: Wtf is a gink?
dodane przez pastapastacannon styczeń 08, 2015
A person who is extremely lame.
"I don't hang out with fuckboy ginks like you"
dodane przez thvrstein czerwiec 03, 2015
A crabby, bitter and unattractive old person. Ginks tend to be impoverished, indignant urban dwellers with the same political and social leanings that they had in their 20s, who blame everyone but themselves for their myriad problems, and accost total strangers to air complaints.
Political demonstrations always seem to include at least one wrinkly, unsmiling, badly-dressed septuagenarian gink sporting a homemade sign and haranguing passersby.
dodane przez SteelEagle grudzień 16, 2008
female genitalia/
(plural) a group of strange friends (the ginks)
(plural) a group of strange friends (the ginks)
dodane przez saz ginka styczeń 14, 2010
derogatory term for a human being
that guy is such a f*cking gink man.
dodane przez Andrew październik 07, 2003
the elusive ginger chinese person, hence G(inger) (ch)INK = GINK
Person A "wow look at that! A gink!"
Person B " woah yeah! you know they're an endangered species?"
Person B " woah yeah! you know they're an endangered species?"
dodane przez obobobobo listopad 03, 2011


text:
SECAUCUS, N.J. - Carlos Correa was all smiles when he heard his name announced, knowing he had made hometown history at the baseball draft.
The Houston Astros selected the 17-year-old slugging shortstop with the No. 1 pick Monday night, making him the first player from Puerto Rico to lead off the draft.
"This means a lot," Correa said from the draft site at MLB Network studios. "We've got a lot of good players there."
It was the first time Houston had the top pick in the draft since 1992, when the Astros selected Phil Nevin - passing on a young shortstop named Derek Jeter, who went five spots later to the Yankees.
"I have read about that," Correa said, calling Jeter his idol as much for the New York captain's character off the field as on. "I want to be like him. He's awesome."
First-year Astros general manager Jeff Luhnow said Correa "has a chance to be a star" who could hit 20-30 home runs in the pros, whether it's as a shortstop or "ultimately maybe third base."
Fact Box
Appel statement
Mark Appel chose not to have a conference call with the Pittsburgh media Monday night, and instead, he issued the following statement: "I'm currently concentrating on winning a national championship and finishing my academic endeavors at Stanford. I will address the possibility of a professional career in due time."
Correa was one of five players in attendance at the draft, but his introduction was far from the most entertaining. Texas high school outfielder Courtney Hawkins did a backflip - after being prodded by a television reporter when a video was shown of him landing one - a few moments after going No. 13 to the Chicago White Sox.
The 6-foot-3, 220-pound Hawkins, wearing a White Sox cap and jersey, spoke to general manager Kenny Williams right after he stuck his landing.
"They said, 'Go do it,' so I went and did it," a smiling Hawkins said. "But Mr. Williams said: 'No more.'"
Joining Correa and Hawkins were Oklahoma State lefty Andrew Heaney (No. 9, Marlins), Louisiana high school shortstop Gavin Cecchini (No. 12, Mets) and Washington high school catcher Clint Coulter, who went 27th to the Brewers.
Heaney, a draft-eligible sophomore, had tears in his eyes after Miami selected him. Sitting with the other prospects in a makeshift dugout, Heaney headed over to shake Selig's hand and soon was wearing a Marlins cap and jersey.
"That's about all that went through my mind is, don't trip," a beaming Heaney said.
While recent drafts lacked first-pick intrigue, Luhnow said the Astros didn't settle on Correa until about an hour before they went on the clock. Several mock draft lists predicted the Astros would select Stanford right-hander Mark Appel, but instead Houston made a somewhat surprising selection - although Correa was considered one of the top five players available.
Appel, who many predicted would be the first overall pick, slid a few spots lower, going to Pittsburgh at No. 8.
The Pirates, who selected UCLA righty Gerrit Cole with the top pick last year, went after pitching again in Appel. The ace of Stanford's staff has a mid-90s (mph) fastball and is 10-1 with a 2.27 ERA and 127 strikeouts in 119 innings for the Cardinal.
In his last start before the draft, he avenged his only loss of the season by beating Fresno State in the NCAA tournament, fanning 11 in a dominant four-hitter.
With the second pick, Minnesota took speedy Georgia high school outfielder Byron Buxton, considered a five-tool player with a bat considered the best among all draft prospects.
"It's an exciting feeling," Buxton told MLB Network. "I'm just ready to go out and play ball."
University of Florida catcher Mike Zunino, who has drawn comparisons to Jason Varitek for his leadership and ability to handle a pitching staff, was taken No. 3 overall by Seattle.
Baltimore went with LSU right-hander Kevin Gausman with the fourth pick, adding a potential ace to its system. The draft-eligible sophomore has had a terrific season for the Tigers, going 11-1 with a 2.72 ERA and 128 strikeouts in 115 2-3 innings.
Kansas City went with University of San Francisco right-hander Kyle Zimmer, a converted third baseman, with the No. 5 overall pick.
The Dons' ace went just 5-3, but had a 2.85 ERA with 104 Ks and only 17 walks in 88 1-3 innings. He threw consecutive shutouts during one stretch.
"He was the No. 1 pitcher on our board," said Lonnie Goldberg, the Royals' director of scouting. "I think everyone should know that. He's the guy we wanted."