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|Rescooped by Kenzibit from Virology News
A large and complex outbreak of hepatitis C virus in Valencia, Spain that began 25 years ago led to the prosecution and conviction of an anesthetist who was accused of infecting hundreds of his patients. Evolutionary analyses of viral gene sequences were presented as evidence in the trial, and these are now described in detail by González-Candelas and colleagues in a paper published in BMC Biology. Their study illustrates the challenges and opportunities that arise from the use of phylogenetic inference in criminal trials concerning virus transmission.
>>Terms like 'basal', 'early-diverging', and 'first-branching' reflect persistent misconceptions about evolution and phylogenies
In 2006 the World Health Organisation coined a new term: "the Glasgow Effect". It resulted from an analysis of life expectancy data in two neighbourhoods in Glasgow, Scotland. One, a prosperous upper-middle-class village outside the central city, Lenzie, had a life expectancy for a male child at birth of 82, up there with the highest... Continue Reading
For those of us involved in curriculum redesign, the University of Leicester Learning Institute has put together a useful page o
Sidney Perkowitz scans the impacts of Star Trek on science, technology and society.
The gut microbiome has an important role in human health, but the role of phages in maintaining the structure and function of the gut microbial community is unclear. Manrique et al. analysed phages that are associated with the gut microbiome of healthy individuals and identified 23 phages that were common in more than half of the individuals. This set of gut microbiome phages was less prevalent in individuals with gastrointestinal disease, which suggests that they have a role in human health. Next, the authors investigated the structure of the phage community using a network analysis tool. They identified 44 phage groups, of which nine were shared across more than 50% of healthy individuals. On the basis of their results, the authors propose the existence of a healthy gut phageome (HGP) that comprises a core, a common and a low overlap group. Future studies are required to elucidate the role of the phageome in health and disease.
HIV hides its genome inside a proteinaceous shell formed by capsid hexamers to evade detection and degradation in the cytosol of host cells; however, the capsid also hinders access of substrates that are essential for reverse transcription, such as deoxynucleoside triphosphates (dNTPs). Thus far, it was unclear how HIV imported dNTPs into the capsid. Jacques et al. now show that a dynamic pore exists in the centre of each capsid hexamer that enables the entry of dNTPs and thereby supports reverse transcription inside the capsid.
The HIV capsid is a conical structure that is formed by a single protein, the capsid protein. Capsid monomers are arranged into a symmetrical hexamer around a central axis and the authors hypothesized that a pore might exist along this axis. However, there was no evidence for such a pore from previous hexamer structures. In fact, previous structures showed that the amino-terminal β-hairpins of each capsid monomer blocked the opening of such a potential pore. When the authors examined this region more closely, including in structures of capsid monomers, they noticed that the β-hairpin is flexible and can assume different conformations by tilting up to 15 Å away from the axis of symmetry. Indeed, when reconstructing a capsid hexamer based on monomer structures with this 'open' β-hairpin conformation, a central pore is formed. The conformational change is likely to depend on the protonation status of a histidine residue at the base of the β-hairpin. This is supported by the observation that structures that were obtained at a high crystallisation pH adopted a closed conformation, whereas structures that were obtained at a low pH adopted an open conformation. Interestingly, at physiological pH, the β-hairpin assumes an intermediate position, indicating high flexibility. Thus, the β-hairpin functions as a 'molecular iris' that controls entry to a central pore in the capsid.
Python Resources for Bioinformatics
Deer hunting season doesn't start for a couple more weeks, but a virus has already taken out dozens of deer.
Diabetes and its concurrent complications impact a significant proportion of the population of the US and create a large financial burden on the American health care system. FDA-approved maggot debridement therapy (MDT), the application of sterile laboratory-reared Lucilia sericata (green bottle fly) larvae to wounds, is a cost-effective and successful treatment for diabetic foot ulcers and other medical conditions. Human platelet derived growth factor-BB (PDGF-BB) is a secreted dimeric peptide growth factor that binds the PDGF receptor. PDGF-BB stimulates cell proliferation and survival, promotes wound healing, and has been investigated as a possible topical treatment for non-healing wounds. Genetic engineering has allowed for expression and secretion of human growth factors and other proteins in transgenic insects. Here, we present a novel concept in MDT technology that combines the established benefits of MDT with the power of genetic engineering to promote healing. The focus of this study is to create and characterize strains of transgenic L. sericata that express and secrete PDGF-BB at detectable levels in adult hemolymph, whole larval lysate, and maggot excretions/ secretions (ES), with potential for clinical utility in wound healing. We have engineered and confirmed transgene insertion in several strains of L. sericata that express human PDGF-BB. Using a heat-inducible promoter to control the pdgf-b gene, pdgf-b mRNA was detected via semi-quantitative PCR upon heat shock. PDGF-BB protein was also detectable in larval lysates and adult hemolymph but not larval ES. An alternative, tetracycline-repressible pdgf-b system mediated expression of pdgf-b mRNA when maggots were raised on diet that lacked tetracycline. Further, PDGF-BB protein was readily detected in whole larval lysate as well as larval ES. Here we show robust, inducible expression and production of human PDGF-BB protein from two conditional expression systems in transgenic L. sericata larvae. The tetracycline-repressible system appears to be the most promising as PDGF-BB protein was detectable in larval ES following induction. Our system could potentially be used to deliver a variety of growth factors and anti-microbial peptides to the wound environment with the aim of enhancing wound healing, thereby improving patient outcome in a cost-effective manner.
The recent outbreak of Ebola virus disease (EVD) resulted in a large number of human deaths. Due to this devastation, the Ebola virus has attracted renewed interest as model for virus evolution. Recent literature on Ebola virus (EBOV) has contributed substantially to our understanding of the underlying genetics and its scope with reference to the 2014 outbreak. But no study yet, has focused on the conservation patterns of EBOV proteins.
We analyzed the evolution of functional regions of EBOV and highlight the function of conserved residues in protein activities. We apply an array of computational tools to dissect the functions of EBOV proteins in detail, i) protein sequence conservation ii) protein-protein interactome analysis iii) structural modeling iv) kinase prediction. Our results suggest the presence of novel post-translational modifications in EBOV proteins and their role in the modulation of protein functions and protein interactions. Moreover, on the basis of the presence of ATM recognition motifs in all EBOV proteins we postulate a role of DNA damage response pathways and ATM kinase in EVD. The ATM kinase is put forward, for further evaluation, as novel potential therapeutic target.
|Scooped by Chad Smithson
This post discusses whether you can skip the adapter removal step in NGS data analysis
|Scooped by burkesquires
Software is a critical part of modern research and yet there is little support across the scholarly ecosystem for its acknowledgement and citation. Inspired by the activities of the FORCE11 working group focused on data citation, this document summarizes the recommendations of the FORCE11 Software Citation Working Group and its activities between June 2015 and April 2016. Based on a review of existing community practices, the goal of the working group was to produce a consolidated set of citation principles that may encourage broad adoption of a consistent policy for software citation across disciplines and venues. Our work is presented here as a set of software citation principles, a discussion of the motivations for developing the principles, reviews of existing community practice, and a discussion of the requirements these principles would place upon different stakeholders. Working examples and possible technical solutions for how these principles can be implemented will be discussed in a separate paper.
|Scooped by Vern Paetkau
(Microscopic image of C. elegans with Nomarski DIC optics: by permission, Prof. Sander van den Heuvel, Developmental Biology, Universiteit Utrecht. About 200x lifesize.) How long can we expect to live in the future? The longest recorded human life is that of a French woman, Jeanne Calment, who died aged 122 and a half, in 1997.... Continue Reading
Here, we introduce a new family of eukaryote-infecting single-stranded (ss) DNA viruses that was created recently by the International Committee on Taxonomy of Viruses (ICTV). The family, named Genomoviridae, contains a single genus, Gemycircularvirus, which currently has one recognized virus species, Sclerotinia gemycircularvirus 1. Sclerotinia sclerotiorum hypovirulence-associated DNA virus 1 (SsHADV-1) is currently the sole representative isolate of the family; however, a great number of SsHADV-1-like ssDNA virus genomes has been sequenced from various environmental, plant- and animal-associated samples, indicating that members of family Genomoviridae are widespread and abundant in the environment.
Ebola is 40 today! The discovery of filoviruses: Marburg and Ebola Marburg virus In 1967, the world was introduced to a new virus: thirty-one people in Marburg and Frankfurt in Germany, and Belgrade in the then Yugoslavia, became infected in a linked outbreak with a novel haemorrhagic fever agent. Twenty-five of them were laboratory workers associated…
The host factors that noroviruses rely on for invasion, replication and pathogenesis, and that consequently determine the species tropism of the virus, are largely unidentified. Virgin and colleagues used CRISPR–Cas9 to perform a genome-wide screen for host factors that are required for the infection of mouse cells by murine norovirus (MNoV). Four loss-of-function mutations in a single gene (Cd300lf) were identified that enabled mouse cells to survive infection by MNoV. Additional experiments in cell lines, primary cells and in vivo confirmed that Cd300lf is specifically required for the binding and replication of MNoV, and that Cd300lf is the primary receptor for MNoV infection. Expressing murine Cd300lf in HeLa cells made these human cells permissive for infection by MNoV, thus removing the species tropism barrier of MNoV infection. Finally, structural analysis of Cd300lf, which is a cell-surface immunoglobulin domain-containing protein, revealed a putative ligand binding site in its ectodomain.
We estimated the speed of Zika virus introduction in Brazil by using confirmed cases at the municipal level. Our models indicate a southward pattern of introduction starting from the northeastern coast and a pattern of movement toward the western border with an average speed of spread of 42 km/day or 15,367 km/year.
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For companies that use time clock, timesheet, or pay employees by salary or commission, Auto Payroll can complete your payroll task in minutes. This tool is very simple to use. No accounting or tax knowledge is required. The tool can be learned in minutes by just following the Instruction Diagram on the Main Window. You only need to use the built-in time clock or timesheet to record employees' work hours, or you can enter employees' gross pay amounts directly. On payday, all you have to do is to click on the Process Paycheck button to generate the paychecks for all employees at once. This tool calculates federal tax withholding, Social Security tax, Medicare tax, and withholding tax for all states. It prepares the State Employer's Contribution and Wage reports, Forms 941, 944, 940, W-2, W-3, 1099-Misc, and 1096. Auto Payroll generates up-to-the minute payroll tax liabilities and labor expenses reports. It also handles non-employee workers, user-defined deduction and income categories.
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ezPaycheck 2010 Payroll Software is More Flexible than Ever Before
Newly released 2010 edition of ezPaycheck payroll software from Halfpricesoft.com gives small and mid-size businesses more options and flexibility in doing payroll and printing checks than ever before. This year's updates include not only updated federal and state tax tables, but also additional printing formats, additional reports, and ability to print Forms 940 and 941. Best of all,...
Mechsoft Announces Online Payroll Software Release
Pune- October 05, 2009 Today Mechsoft announced its launch of Online Payroll Solution for Small and Mid Size Enterprises. In the time of hard hitting economy managing Human Talent has gained importance. Business Houses and Enterprises have strongly started looking for key Human talent management solutions for Right sizing the organization. With Key Objective to make the Business Owner...
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Newly released 2010 edition of ezPaycheck payroll software version 3.0.8 from Halfpricesoft.com gives small and mid-size businesses more options and flexibility in doing payroll and printing checks than ever before. The latest version includes more features on payroll check format, which allows user to disply whole SSN number or mask partial SSN. Best of all, this easy-to-use payroll and...
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HR2Payroll helps automate Small and Medium Enterprises (SME) their Employee s HR, Payroll Benefits and Statutory Compliances functions, easily without any IT overheads. Signup for an HR2Payroll account. Then begin using it 24x7x365 days basis, from office, home or any place in the world that has Internet connectivity It is latest technology and one of the very first in India based on the...
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Inductive Automation announces the release of FactorySQL 3.0 and FactoryPMI 2.0, paving the way for a redundant web based SCADA system Released on = March 7, 2007, 8:13 pm Press Release Author = Inductive Automation Industry = Software Press Release Summary = FactoryPMI Version 2.0 and FactorySQL...
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AXMEDIS 2008: 4rd International Conference on Automated solutions for Cross Media Content and Multi-channel Distribution
Integration of software engineering and content technologies supporting the content production and multichannel distribution, interoperability, knowledge, protection and semantics aspects. AXMEDIS2008 aims to explore all subjects, latest developments, future trends, of technologies and their applications. With a particularly attention to new concepts, requirements, prototypes, research ideas,...
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InterContinental Almaty
If you are visiting Almaty, you shouldn't miss out on the opportunity to visit our beautiful mountains. At a distance of 25 km from the city and at 2 260 m above the sea level you will find Shymbulak ski resort. Heavy snowfall and majestic mountains make Shymbulak the perfect place for skiers and snowboarders of all abilities. Sky season noramlly begins in December and can run into April. You can check the visibility through their webcam on www.shymbulak.com. Shymbulak is a place to relax, not only in winter, but also in summer. Shymbulak Ski Resort and Medeu ice skating rink are great prospects and favorite places for recreation and entertainment for Almaty residents and tourists.
The afternoon is the best time to visit Panfilov Park. The memorial in the park is in memory of the 28 soldiers of an Almaty infantry unit, who died fighting the Nazis outside Moscow. In front of the giant black monument you can watch an eternal flame, honouring the fallen of 1917–20 (the Civil War) and 1941–45 (WWII). At its heart stands candy coloured Zenkov Cathedral, an orthodox wooden church, where divine worships are conducted every day at 16:00. After pleasant walk in the park, make sure you get to the Green Bazaar, which is a great place to feel the real atmosphere of central Asia and to get involved with a bit of "haggling" and sampling of local produce. This large, two-level market has a wide choice of goods to buy: souvenirs, nuts, vegetables, fresh and dried fruits.
Koktobe is the mountain right in the centre of the Almaty and from its summit you get the best panoramic views of the city. In the evening ride the cable car up from Satpaeva and Dotstyk. It takes just five minutes to ascend to the observation point and back-to-back costs 2000 Kazakh Tenge. There are three restaurants up here and one of them, Grill Bar, is situated just on the edge of the mountain so you can enjoy spectacular views while you eat. In addition there are several small boutiques and an art gallery to browse through, with souvenirs to buy.
Almaty's name
The name Almaty comes from Alma-Ata, and literally means father apple.
Ancient shopping
The Green Bazaar is one of the most famous and oldest bazaars in the city. The experience of buying fragrant fresh fruit and vegetables, spices and dried fruit has hardly changed over the centuries.
Medeo is an area of outstanding natural beauty and home to the world's highest mountain speed skating rink. Only 30 minutes away from the hotel.
The city
Almaty is the former capital city of Kazakhstan and is the country's largest city. It is also the cultural and financial centre of the country. The variety of entertainment available here attracts people from throughout Kazakhstan and reinforces the city's multi-cultural population.


text:
Add Coconut Water to your Life... and Prosper
Coco Cafe coconut water is the newest addition to my post-workout shakes. The company had a booth at the NorthCentral CrossFit Regionals, were kind enough to share a few containers with me, and I was hooked. I'm finding Coco Cafe in my local grocery stores, so haven't had to order it through any specialty retailers or Amazon.
Of course I'm continuing to use Progenex Recovery and Vitargo immediately, in the gym, right after I stop shaking and get my ass off the floor. But at home, when the mighty Blendtec is out, this delicious Coco Cafe coconut water goes right into the blender. Eleven ounces of gluten-free goodness; the flavor is nice, and the nutritional benefits of coconut water are on record.
For the recipe hounds out there; each blender-full creates two meal shakes. When I use coconut water I leave out the coconut milk! Add some almond butter or a handful of almonds, flaxseed meal, Fiberlyze, BCAAs of your choice, a handful of berries, and protein. Currently I'm using two scoops of Gaspari MyoFusion and two or three scoops of Onnit HempForce. I love HempForce!
The mocha flavor, my favorite so far, contains 140 calories. Fat is 3.5 grams, 22 grams carbs, 19 of which are sugar. Happily, coconut water is the first ingredient on the listing. Oh, and I shouldn't forget one of my favorite things about Coco Cafe; each container has one shot of espresso!
On some hot and humid late summer days, an hour or two after working out and still feeling wrecked, I would drink a Coco Cafe by itself. I felt it helped with the eternal dehydration of summer training. Now that winter is settling upon us here in Wisconsin, not a problem.
Add Coco Cafe to your shakes! Experiment with recipes and see which flavors work best for you.


text:
Connecticut Technical Schools
Welcome to one of the smallest states in the union but one of the richest. Per capita, Connecticut is ranked number one when it comes to income for residents. Students can gain the skills they need to succeed in Connecticut through technical schools and colleges.
One career that is seeing an increase in demand is government positions. Students can get the skills that are required to find entry-level employment in the government sector. With so many different departments, your options could be limitless with the right training from a Connecticut technical college.
Another great area of growth in Connecticut is their industrial output, which includes the making of helicopters, transportation equipment and parts for nuclear submarines. Connecticut technical schools can give you essential skills for any one of these in-demand careers.
Most Popular Connecticut Technical Schools and Colleges
Additional Connecticut Technical Schools and Colleges
Technical Schools Guide makes finding the right Connecticut Technical Schools simple. We list both large and small Technical Colleges throughout the United States. Whether you are planning on attending a 2-year college, 4-year college, vocational college, purely technical college, or just single college courses, the listings above should contain each type of trade school, college, or university. Financial aid is available for many of these colleges but visitors will need to contact each school directly to get assistance. Technical Schools Guide does not maintain specific course, tuition, application, accredation or records of information on specific schools. All inquiries should be made directly with such schools. All information contained above is believed to be accurate and reputable. If a discrepancy is found, please contact the Technical Schools Guide staff by clicking on the "contact us" link below. We are also able to update college information and locations through this contact address. Featured listings on Technical Schools Guide are generally for-profit school listings. These listings help pay for bandwidth and maintenance of the Technical Schools Guide site. Thanks for visiting Technical Schools Guide and good luck in your Connecticut Technical school experience!
-The Technical Schools Guide staff. To contact us, click here.
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If anyone is interested in running DLR languages on WP7, the latest MSDN Magazine has an article on IronRuby.
If anyone is interested in running DLR languages on WP7, the latest MSDN Magazine has an article on IronRuby.
vesuvius said:elmer said:*snip*
Surely that where Google Android comes in, litigation via Oracle withstanding?
There is absolutely nothing that WP7 offers that Android does not at present, and it is aesthetically pleasing. I like the metro design, but the droids aren't exactly an eyesore. The multi-touch is fantastic, and the text rendering is gorgeous (something I'm still yet to be conviced about on Silverlight)
Yes there is a greater developer-base for WP7, but what tools do hobbyists have to create WP7 applications?
I think an expression blend express is long overdue, the longer a key component like that is unavailable for the bulk of developers and hobbyists, then the harder it will be to play catchup
The developer tools for Windows Phone (which include Visual Studio Express 2010 for Windows Phone, XNA Games Studio 4, Expression Blend 4 for Windows Phone, and the emulator) are free. You'll be able to download the final release of the tools this Thursday.
Hobbyists may download and use those tools to develop apps for Windows Phone 7.
For pros that already have the commercial SKUs of VS or Blend installed, app templates, documentation, etc. from that same download will be added to their existing installs.
64-bit device drivers have been a Windows Logo Program requirement since it was revised for Vista.
I've been using this Encore adapter since Windows 7 was in Beta or RC:
It was around $17+shipping when I got it. It doesn't appear to be available for less than $40 now.
I use the chipset manufacturer's drivers (Ralink RT2870) - driver-only install, and have never had a problem on Windows 7 x64.
This AZIO adapter also uses a Ralink chipset and is currently $20.
@Beatbuster - The wg111v1 uses an Intersil PrismGT chipset. I could not find a Windows x64 driver for this chipset. The one on Netgear's site is 32-bit. The other versions of the wg111 use Realtek chipsets, (RTL8187L for v2, RTL8187B for v3) so their drivers won't work with your v1.
littleguru said:
One thing that I don't like about the search in 7 is that you need to know all these words, like for example "kind". I would have never guessed that "kind:picture" works after all. It's hard to discover, in my eyes. It's powerful, that's for sure, but still hard to discover.
It would be nice to have a UI that gives me all these keywords so that I could build (by clicking on checkboxes, or something similar) the queries. And I mean all keywords and not just some of them, like the current drop down does...
Other than that I'm really happy with the search that's included in 7. It's fast, seems to use less resources and I quite never use dir /s again
The properties you may filter on are right in Explorer.
Any of the metadata names can be used as search filters. You can use the column dropdown controls to filter without having to remember the term to type. You can also right-click on the column header, then click More... to see all properties supported by that version of Explorer (or check the file properties dialog for metadata specific to that type of file). If a property name is composed of multiple words like Date Taken, remove the space, so you would type datetaken: in the search box.
PaoloM said:AndyC said:*snip*
Well, i was looking for something more automated
You might check www.pdfsharp.com for XPS->PDF conversion. The latest build includes a converter preview.
For going the other way, I haven't seen any free tools. You may be able to use PDFSharp to open the PDF and XpsDocumentWriter or System.Printing to convert to XPS.
Samsung Licenses Microsoft Technology for Wireless Digital Photo Frame
Samsung SPF-83V (8" Frame, wireless, a bit over $200)
It appears they simply didn't add .PNG to the list of filters for the Browse dialog in Personalize. You can type *.* or *.png in that dialog so that PNGs show up. However, you can also just right-click on any PNG in Explorer and choose Set as Desktop Background.
blowdart wrote:
mawcc wrote:
Is that insider information or just guessing?
People are blogging at teched already
It's also confirmed in a PR released today:
Microsoft Commits to November Release Date for Visual Studio 2008 and the .NET Framework 3.5
These latest releases are part of the broader Microsoft Application Platform, a portfolio of technology capabilities and core products that help organizations develop, deploy and manage applications and IT infrastructure. They also mark another major milestone leading up to the global launch of Windows Server 2008, Visual Studio 2008 and SQL Server 2008 on Feb. 27, 2008, in Los Angeles.
Product Information and Availability
Visual Studio 2008 and the .NET Framework 3.5 will be available by the end of November 2007. The .NET Framework 3.5 will also be available to end users via a free, optional download from Microsoft Update. A CTP of Microsoft Sync Framework is available today at http://msdn.microsoft.com/sync. Popfly Explorer is a hosted development environment available today at http://www.popfly.com/">http://www.popfly.com. More information about all of these releases is available at http://www.msdn.microsoft.com/vstudio.
mikexkearney wrote:Sorry to butt in...is anyone using MS Virtual PC 2007?
I was just watching the demo and it said it was part of Vista, (a reason to migrate, apps wise) but I didnt even know it was included in the new of OS...was this pulled from Vista?
It's not part of Vista, but it is a free download:
Linux VM Additions:
As for running Linux (and other OSes) on VPC, check out The Sean Blog. Here's a guide for Ubuntu Gusty:
And here's posts about other OSes:
Sven Groot wrote:That looks really bad. Are you sure you don't have faulty RAM or something?
Or are overclocking?


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on May 24, 2013 - 12:01 AM
, updated May 24, 2013 at 7:36 AM
Gearing up for some garden tours? Grab your calendars because they're coming up fast and continuing all summer long. You'll find more than 20 of them listed here from around the region, and many are still accepting garden entries. They're self-guided, so you can proceed at your own pace.
Most are part of the fourth annual National Garden Festival, which runs June 21 to Aug. 4. In addition to these local garden walk and tours, the festival features all things gardening – bus tours, weekday Open Gardens, speakers and workshops. Visit www.nationalgardenfestival.com for the schedule and lots of additional information, including on the new GObike Buffalo City Garden Tour on June 23 and the Beyond the Flowers tour Aug. 3.
And then pick a few walks or tours you won't want to miss. Take a look:
Coming in June
• The Shaw Garden Tour: The Secret Gardens of Niagara-on-the-Lake will take place from 10 a.m. to 4 p.m. June 8 in Niagara-on-the-Lake, Ont. This year's walkable tour showcases gardens surrounding historic homes. Master gardeners will be on hand to answer questions. Tickets are $20; call the Shaw Festival box office, (800) 511-7429. For more information, visit www.shawfest.com/gardentour.
• The fourth annual display of Bikes in Bloom in Clarence Center kicks off June 5 and runs through mid-August. The free event features an estimated 30 bicycles decorated with flowers, plants and other materials – some unique – by local residents and businesses throughout the Clarence Center community. Maps will be available from merchants at the Four Corners, Goodrich and Clarence Center roads.
• The eighth annual Lewiston GardenFest, a free event sponsored by the Lewiston Garden Club, features a garden walk and other garden-theme activities from 10 a.m. to 5 p.m. June 22 and 23. In addition to approximately seven open gardens in the village, there will be daily speakers, master gardeners, soil testing, vendors and a potted container contest along Center Street. Pick up maps at the hospitality booths. Visit www.lewistongardenfest.com for more information on the tour, the garden club or to register your garden. Or visit Lewiston Gardenfest on Facebook.
• The North Tonawanda History Museum will hold its Historic Treasures Tour of historic homes in North Tonawanda from noon to 6 p.m. June 8. Gardens will also be on view. Tickets may be purchased in advance for $18 through the museum. Phone: 213-0554. Website: www.nthistorymuseum.org.
• The 10th annual Jamestown Audubon Center & Sanctuary's Secret Gardens Tour of six gardens in Lakewood, Busti and Jamestown will take place from 10:30 a.m. to 4 p.m. June 29. Tickets are $10 and available at the Jamestown Audubon Center and nurseries in that area. Tickets can also be purchased at participating gardens on tour day. Call 569-2345 or visit www.jamestownaudubon.org.
• The Parkside Community Association will present the 16th annual Parkside Garden Tour from 10 a.m. to 4 p.m. June 30. Suggested donation is $8. An optional guided architecture/history walk is $10. All proceeds support the PCA. As usual, the tour begins at Church of the Good Shepherd, 96 Jewett Parkway, where bike rentals will be available for $15. Bring your own helmet. Residents can register their gardens until June 21. Visit www.parksidebuffalo.org/gardentour for application and additional information on the tour and other events happening that day, including a plant and garden tool sale at the Darwin Martin House complex and the Buffalo-style Garden Art Sale in nearby Delaware Park at the Lodge on Parkside Avenue.
Coming in July
• A Grand Island Garden Tour of private and public gardens is being planned for 10 a.m. to 6 p.m. July 6 and 7. This is the first tour organized by Serene Gardens as part of the National Garden Festival. Visit www.serene-gardens.com. Headquarters is Serene Gardens, 2800 Grand Island Blvd. For information, email: firstname.lastname@example.com or call 773-LEAF.
• The City of Tonawanda Garden Walk, now in its third year, will take place from 10 a.m. to 4 p.m. July 13. An expected 35 or more gardens will be featured in this free event presented by the City of Tonawanda Board for the Visual and Performing Arts and the Garden Club of the Tonawandas. Applications are available on the city's website, www.ci.tonawanda.ny.us. and on the City of Tonawanda Garden Walk Facebook page. They're also available in the mayor's office, the Recreation Department, the senior center on Main Street, the public library and at local businesses. Deadline is June 1; maps for the walk will be available beginning July 1 at the previously mentioned locations.
• The ninth annual Village of Hamburg Garden Walk will be held from 10 a.m. to 4 p.m. July 13 and 14. Map guides for this free event will be available at Memorial Park, corner of Lake and Union streets, Hamburg. Garden vendors will be in the park both days. For more information, visit hamburggardenwalk.com or call Marg Rust at 648-7544. Applications for village residents are available on the website; deadline is June 15.
• The 12th annual Samuel P. Capen Garden Walk of more than 60 private gardens and public spaces will take place from 10 a.m. to 4 p.m. July 13 in the neighborhoods surrounding the University at Buffalo's South Campus. Maps will be available walk day at University Community Farmers' Market on Main Street and Kenmore Avenue; University Heights Tool Library, 5 W. Northrup Place; and UB's Anderson Gallery, 1 Martha Jackson Place. Visit www.ourheights.org to enter your garden; the deadline is June 15. To view a photo gallery, visit Capen Garden Walk on Facebook.
• The Historic Niagara Falls Garden Walk is scheduled from 10 a.m. to 2 p.m. July 13. Gardens in the Orchard Parkway and Park Place historic districts will be featured. Headquarters will be at the Niagara Hub at Park Place and Main Street, Niagara Falls, where you will find free maps. For details on entering, call 285-1318.
• The ninth annual Lockport in Bloom will take place from 10 a.m. to 4 p.m. July 13 and 14. Headquarters for the free tour is at the Kenan Center, 433 Locust St., Lockport. A Twilight in the Garden evening tour will run 6:30 to 9 p.m. July 13. Learn more at www.lockportinbloom.com.
• St. James Church and Landmark Society of Genesee County Home and Garden Tour will take place from noon to 5 p.m. July 14. Ten gardens will be featured, with three homeowners opening their first floors to visitors. A dessert reception and garden talk by landscape designer Tim Richley is planned from 4:15 to 5 p.m. at St. James Church, 405 E. Main St., Batavia. Tickets, $20, will be available a month ahead of time at the church office and Harrington's Produce in Batavia. For more information, call Marcia Gann at (585) 343-8218.
• The Orleans County Cornell Cooperative Extension's master gardeners will hold their fifth annual garden tour from 9 a.m. to 3 p.m. July 13. Six gardens will be featured. Tickets are $10. For information, call (585) 798-4265 or email: email@example.com. Website: cceorleans.shutterfly.com.
• The 11th annual Snyder-CleveHill Garden View of about 25 residential gardens and public spaces will run from 10 a.m. to 4 p.m. July 14. Headquarters is in front of Trillium's Courtyard Florist, 2195 Kensington Ave., Snyder. A $3 donation is suggested. For questions, email: firstname.lastname@example.com. Snyder-Clevehill Garden View is on Facebook.
• Now also in its 11th year, the free Ken-Ton Garden Tour will take place from 10 a.m. to 4 p.m. July 20 and 21, with the Saturday Nite Lights tour of select illuminated gardens from 8:30 to 10:30 p.m. July 20. The registration deadline is June 7. All interested gardeners in the Town of Tonawanda and Village of Kenmore are welcome to register online or by mail. Visit www.kentongardentour.com for tour information and to register online or download and print a paper application. Paper applications are also available in the town supervisor's office in the Municipal Building, 2919 Delaware Ave., Kenmore.
• The 10th annual Village of Williamsville Garden Walk will take place from 10 a.m. to 4 p.m. July 20. More than 25 gardens within a square mile are expected to participate in this free walkable/bikeable event. "Garden Passport" and map will be found at the welcome tent in front of Village Hall, 5565 Main St., Williamsville. This is a village-wide event with a farmers' market, garden-themed menus at restaurants and cafes, free garden talk and more. To register your garden, email: firstname.lastname@example.com or call Village Hall at 632-4120, Ext. 3009. Deadline is July 8.
• The fourth annual Amherst Garden Walk is scheduled for 10 a.m. to 4 p.m. July 20. Free maps will be available a day or two ahead on the town website, www.amherst.ny.us, and on tour day at the Amherst Municipal Building, 5583 Main St., Amherst. Visit the town website and enter the keyword "Garden Walk" to apply online or download the application. The deadline is June 30. For more information, send an email to: email@example.com. Or call the Town Supervisor's Office at 631-7033. Amherst Garden Walk also is on Facebook.
• The free Lancaster Garden Walk will run from 10 a.m. to 4:30 p.m. July 20 and 21 and will feature residents' gardens throughout the Village of Lancaster and Town of Lancaster. Programs will be available July 18 at Two Chicks & a Rooster, 732 Aurora St., and Petals to Please, 63 Central Ave. For a garden walk entry form, visit www.lancastervillage.org/gardenpage.htm. Deadline is June 1.
• West Seneca's Tour of Home Gardens is planned for 10 a.m. to 4 p.m. July 20. Those interested in entering their garden can contact Dave or Sharon Pulinski at 824-3995 or by email: firstname.lastname@example.com.
• The 13th annual South Buffalo Alive's Tour of Gardens will take place from 9 a.m. to 3 p.m. July 21. On tour day, you can pick up a map from 9 a.m. to 1 p.m. at tour headquarters – Tim Russert Children's Garden next to the Dudley Library, 2010 South Park Ave. Suggested donation is $2. See www.southbuffaloalive.com for updates. Gardens can be registered until July 7 by calling Marge Ryan, 826-3158. South Buffalo Alive is on Facebook.
• Garden Walk Buffalo gets under way from 10 a.m. to 4 p.m. July 27 and 28. Called the largest garden tour in America, it's free and includes more than 380 city gardens in clusters within a 3-mile radius. The three headquarters for maps, information, merchandise are: Richmond-Summer Senior Center, Richmond Avenue and Summer Street; Buffalo Seminary, 205 Bidwell Parkway; and Evergreen Health Services (formerly AIDS Community Services), 206 S. Elmwood Ave., corner of Chippewa Street.
New this year: "An Evening of Wine and Roses," 5 to 9 p.m. July 26, which features wine, hors d'oeuvres, desserts, a luxury coach tour of three gardens, master gardeners and musicians. Tickets are $100 each and limited. You'll find more information on this and Garden Walk Buffalo on the website, www.gardenwalkbuffalo.com.
Coming in August
• The ninth annual Black Rock & Riverside Tour of Gardens is scheduled from 10 a.m. to 4 p.m. Aug. 3 with a Starry Night Garden Tour of select gardens from 8 to 10 that evening. Headquarters for this free tour: St. Mark's Church, 311 Ontario St., and Buffalo Religious Arts Center, 157 East St. Residents can enter their gardens at www.brrgardenwalk.com; deadline is June 3. Maps will be available for downloading and mailing in July.
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Home > Parties > Shut | Eyes Wide Shut Gallery
Shut and Dave Ortiz got their Halloween on early last night with their Berentzen-fueled "Eyes Wide Shut" party at 200 Orchard. There were some of the biggest names in NYC skate in the house – see if you can figure out who they were. All the heads after the jump.
Ha, damn you guys. Look at Corporan and Ortiz, that shit is pretty damn funny!
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WAILUKU - A man who said he thought it was OK to sell marijuana because he was only selling the drug to tourists in Lahaina was sentenced to a one-year jail term.
Daniel Tapaoan, 50, of Kahului also was placed on five years' probation Sept. 27.
He was arrested May 29 for selling marijuana near Banyan Tree Park, police said.
Second Circuit Judge Rhonda Loo took issue with Tapaoan's comments to a probation officer that he thought what he was doing was OK because it was only marijuana, because he was selling to tourists, not locals, and because he was selling in Lahaina.
"I don't care if you're selling marijuana or meth. I don't care if you're selling to tourists or locals," Loo told Tapaoan. "A 50-year-old engaging in this kind of behavior is completely out of the picture."
Tapaoan had pleaded no contest to promoting a controlled substance in or near a public school or park.
The felony charge applies to drug distribution within 750 feet of a school, school vehicle or public park.
In addition to being arrested near the park, Tapaoan was near King Kamehameha III Elementary School, police said.
"He was caught selling overpriced marijuana under the Banyan Tree, which made it a felony," said Deputy Public Defender William "Pili" McGrath. "He seems to be a harmless enough guy. The punishment is quite severe for what the activity is."
Tapaoan needs to find another way to make a living, he said.
Deputy Prosecutor Timothy Tate said Tapaoan has a long history of drug use and contacts with the court system.
Under terms of a plea agreement, Tapaoan could be released from jail after six months to enter drug treatment.
"You probably should be going to prison right now," Loo told Tapaoan. "But it's been quite a while since your last conviction. This is your last chance."


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If image really is everything, then Richard Edelman is a useful person to have on side. Mr Edelman, 54, is the president and chief executive of Edelman - the world's largest independent public-relations firm. The company helped turnaround around ailing Wal-Mart - the world's largest retailer - which reported a surge in quarterly profit in August, topping Wall Street's expectations, and conducts work for heavyweights such as Microsoft, General Motors and Starbucks. It was recently drafted in by the Abu Dhabi United Group to provide support for their take-over of Manchester City football club.
"We are well ahead of anybody else who is not part of a Sorrell-like advertising holding," he tells JC Business, referring to WPP boss Sir Martin Sorrell (one of our Expert View columnists).
"It's an exciting business because it's no longer communications dominated by advertising. People recognise that PR has a unique and growing role in policy, as well as to communicate."
How would he market Israel? While acknowledging that focusing on the holiday opportunities is great as a consumer model, he says: "Israel has done a very good job with technology and bio-science. It would be good to have a few more hero faces, like technology entrepreneur Shai Agassi. Make the Israel story less about politics and more much more about all the people who are making real breakthroughs in technology - a business-focused image as opposed to consumer."
Edelman was founded in Chicago in 1952 by Mr Edelman's father Dan Edelman, now 88. He remains an active chairman. Mr Edelman junior, who lives in the United States, joined in 1978, and the company has grown from a $6 million to $450 million business. It has offices in 52 cities and employs more than 2,700 people. Last year, the firm grew 26 per cent globally to a $376 million revenue.
He says the firm has not been too affected by the economic downturn. "We are performing much better than in earlier times of economic stress. First of all, the dispersion of media and the acceptance that there is a multiple-stakeholder model: it used to be that you could just talk to consumers. It doesn't work that way any more.
"I don't think it's going to be a buoyant year, but I think it's going to be OK.
"There's cyclical and then there's secular. The secular trend is away from advertising and towards things like PR."
He acknowledges that businesses are cutting their advertising budgets, but not necessarily their PR budgets.
"PR also has the effect of being an incredible multiplier. If you get it right, it can have a ten-times kind of influence, whereas advertising might have a three- of four-times influence.
"I think the order has changed. You have to have some buy-in to a proposition before the advertising can really work and there is such cynicism and distrust of institutions right now."
According to Mr Edelman - who cites research carried out by the company - the number-one trusted source of information is peer group, not the government or establishment media.
"That's a huge change. Whether it's Northern Rock or dodgy dossiers in politics, people just don't trust institutions to tell them the truth." He says trust in chief executives is around 25 per cent in the UK.
The firm has crafted many key campaigns, such as the Dove Campaign for Real Beauty, which Mr Edelman cites as one of the company's top five. Other memorable ones are Persil's Dirt is Good and working with Heinz on dolphin-safe tuna in the early 1990s.
Why are these so successful? "Because at their core they have a purpose and they are not just trivial." The firm also alerts consumers to products or problems and successfully promoted landing rights for the Concorde supersonic jet in the early 1970s.
Still, it has not always been easy. In 2006, Edelman was at the centre of controversy in 2006, when the firm was exposed for creating fake blogs on behalf of Wal-Mart.
On a personal level, Mr Edelman, was recently diagnosed with prostate cancer. Last month, he successfully underwent surgery at Memorial Sloan Kettering Hospital in New York, where he lives. He is keen to return to work. An active blogger - 16,000 people read his blog every month - he has been chronicling his experiences online at www.edelman.com/speak_up/blog.
As for the main challenges facing PR today, he notes: "We still have to get beyond the stereotype that PR means media relations, PR as spin-meister creating reality, and that PR is about attractive young girls holding parties. So, either we are the genius manipulators of the world, or idiots who send out press releases. And I reject both of those."
Edelman makes much of its claim to be committed to ethical behaviour. In 1999, the company dropped ties with any tobacco-related business.
"I felt very good about that, because it was the right thing to do.
"We have really tried hard to have good relations with civil society, and by and large we have succeeded with that. We are a family business and we take our responsibility to ethical behaviour further than the written rules of the law. Our family has been at this for 55 years. Nothing is worth reputational damage."
A Harvard graduate, Mr Edelman is proud of his Jewish roots and those of the company. Prior to establishing the business, his father had been in service in World War Two in psychological warfare. He was trained to analyse Nazi radio broadcasts.
Following the war, he went to work for CBS News, before moving into PR and starting his own agency.
Many of their initial clients Jewish entrepreneur, including Charles Lubin, the founder of the Sara Lee cakes range.


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About Martinelli Winery
Martinelli Winery is truly a creation born out of love. Founders Giuseppe and Luisa Martinelli eloped from their native Tuscany in 1895, with little more than their knowledge of winemaking, and set out to make a life in the new world. Over a century later, we can safely say that they succeeded.
1999 Martinelli Winery Chardonnay Gold Ridge Russian River Valley
Producer: Martinelli Winery
Style: White Wine
Grape Type: Chardonnay
Origin: California
Region: Sonoma
89 Points | Connoisseurs' Guide to California Wine
91 Points | Stephen Tanzer's IWC - May/June 2001
Slightly hazy appearance. Deep, spicy aromas of orange peel and butterscotch. Round, velvety and impressively glyceral in the mouth, with spicy, vanillin oak serving to frame the fat flavors. Already quite accessible.


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The last month of the 1988 Major League Baseball season was dominated by Orel Hershiser's record-setting scoreless-innings streak. But while Hershiser closed the season with 59 consecutive scoreless innings, the Los Angeles Dodgers entered the postseason as distinct underdogs. First they needed to overcome the mighty New York Mets: the winners of 100 games featured deep pitching, balanced power and a battle-tested roster. Then awaiting in the Fall Classic would be the powerful Oakland Athletics. Led by the Bash Brothers, Jose Canseco and Mark McGwire, this stacked squad had won 104 games and then swept the Boston Red Sox in the American League Championship Series. But as the seven games in this remarkable DVD collection prove, "that's why they play the games." The Dodgers had the ever-optimistic motivation of Manager Tommy Lasorda. The Dodgers had the ferocity and bulldog determination of Hershiser. The Dodgers had the singular cast of players who far exceeded the sum of the parts and became an unstoppable team. Finally, the Dodgers had the inspirational lion-hearted leadership of the 1988 National League MVP Kirk Gibson, who with one dramatic swing crushed the spirit of the Athletics and carved out a special place in the World Series pantheon. This 7-disc DVD collectible is the perfect gift for the Dodgers enthusiast in your life! Running time is approximately 17 hours, 50 minutes total plus extras.
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Look what Daddy did.
Matteo Joel Nash was only a few hours old when his father gave him a birthday present that was the family's second biggest delivery of the day.
Nash's wife, Alejandra, gave birth to their third child and first son Friday morning. Nash missed the team shootaround but shot all around and over Sacramento for 28 points, 14 assists and seven rebounds in the Suns' 103-89 victory at US Airways Center.
Nash nearly had his fourth career regular-season triple-double but still recorded a season high in scoring on 13-of-18 shooting. Nash only had two previous games of at least 28 points, 14 assists and seven rebounds in 2006 and 2007.
Nash was unavailable for comment after the game to return to his family, leaving co-captain Grant Hill with a request to be his spokesman.
"I played great, eh," Hill offered before relating to Nash's emotions, saying, "Anytime with the birth of a child, you get fired up. When he hit his first couple shots, you knew he was going to be aggressive.
"He was really aggressive, attacking from the start. He put pressure on the defense. He got Robin (Lopez) some easy looks early and really set the tone for us."
Nash made 11 of his first 12 shots until he tried his first 3-point shot late in the third quarter. And the Suns (4-4) needed his points too, for how the Kings were defending to surrender jump shots to Nash and how the rest of the Suns offense was quiet.
"We were the victim of a Hall of Fame player having a Hall of Fame night," Sacramento coach Paul Westphal said. "Steve Nash was unspeakably sensational with his decision-making and his execution. We tried double-teaming him. We tried making him score and taking away his other options. We tried zoning. Everything we tried, he had the answer for. If I wasn't sitting on the visitors bench, I would've been applauding him."
Jason Richardson was the only other Sun in double figures until the fourth quarter, when Phoenix needed Nash most.
The Suns reserves fared well in the first half to extend a lead but the all-reserve lineup started the fourth quarter by missing its first six shots and making two turnovers. The Kings, 3-5 after losing four in a row, cut the lead to 77-75 as Nash returned.
From there, the Suns scored on 11 of the next 12 possessions to hand Sacramento its 10th consecutive defeat in Phoenix and sixth in a row in the series.
Again, Hakim Warrick finished the game in place of Hedo Turkoglu because Warrick's pick-and-roll ability with Nash caused the separation. Warrick scored 11 in the fourth, mostly on Nash dishes.
Sacramento had 21 offensive rebounds but only went 6 for 19 on its second chances. The Kings shot 40.9 percent but also nearly got a triple-double from Tyreke Evans, who made seven of 18 shots.
The Suns went from 23 turnovers Monday at Memphis to 11 on Friday.
Key player
Steve Nash made 13 of 18 shots and scored 28 points. He added 14 assists and seven rebounds.
Key moment
Nash returned to the game after Sacramento had cut the deficit to two, and the Suns scored 11 points on the next four possessions.
Key number
13: Shots Sacramento missed on 19 second-chance attempts.
The Suns needed nearly three quarters Friday night to grab as many rebounds (31) as the Timberwolves' Kevin Love had Friday. The peculiar thing about the Suns' rebounding problems is that it happens only on the defensive end. There, Phoenix is the NBA's worst. On the offensive boards, the Suns entered Friday ranked sixth.
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Nov. 12, 2010: Phoenix Suns' Steve Nash dives to the basket against Sacramento Kings' Omri Casspi (right) during the Suns win.
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Changing the Narrative for Early Childhood Investment
Shonkoff JP.
JAMA Pediatr. 2014;168(2):105-106.
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Arizona Cardinals
Arizona Cardinals QB Kevin Kolb on injured ribs: 'They feel good'
Arizona Cardinals quarterback Kevin Kolb has not played in a game since getting hurt against the Buffalo Bills on October 14.
Kolb suffered rib and shoulder injuries, and has only recently returned to the practice field in a limited capacity.
With his health improving, though, people are starting to wonder when he'll be ready take the field again.
"They feel good," he said of his ribs. "I think the biggest thing is what level can I actually go and play at right now.
"That's what I'm trying to work through, is getting all the way back to, I can't say 100 percent, but trying to get back to where velocity is there and all that kind of stuff."
Kolb passed for 1,169 yards and eight touchdowns with just three interceptions this season, guiding the Cardinals to a 3-2 record as a starter.
The Cardinals have not won since he went down, though, and with the team's continued struggles at the quarterback position, the hope is he'll be able to return in the very near future.
That will not happen until he — or at least, his ribs — can handle the beating that comes with being an NFL quarterback.
"There's a number of certain things that bother it," Kolb said of the injury. "And it's not just bothering it, but it's affecting my performance."
When that is not the case you can expect to see Kolb back on the field. However, there is no set date or time frame for when that will happen, and it's worth noting he would not rule out being able to go Sunday against the Jets.
"We're not sure yet, it's open-ended," he said, adding that was about to talk with the training staff to get their thoughts on his progression.
"It obviously hurts where the injury happened, but I wouldn't say it's necessarily a pain thing that you can't play through," he added. "Is it healed enough to take that shot without re-breaking it or whatever.
"And like I said, going out there and being able to play at a high level."
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News release - 2/5/2014
Published 2/5/2014 (all press releases for this day)
DETAILS: At approximately 12:22 PM on Wednesday, 2/5/14, the Oxnard Police Department's Emergency Communications Center received a call from Ventura County Behavioral Health. The staff member reported that a 42 year-old woman called Behavioral Health and said that she was going to commit suicide. The female said that she was at Del Sol Park with a loaded handgun, and that she was going to kill herself.
Oxnard police officers were dispatched to respond to this call. The primary officers who responded had previously attended Crisis Intervention Training (CIT). CIT training is designed to assist officers in de-escalating potentially dangerous situations with persons suffering from mental illness.
Officers made contact with the woman in the park, and attempted to gain her cooperation. The officers indicated over the police radio that the woman had a handgun, and was non-compliant.
Preliminary information indicates that shortly after the officers contacted her, the woman raised the handgun and pointed it at the officers. Two officers fired their service weapons.
The woman was struck by gunfire. No officers were injured. Officers immediately requested that emergency medical services respond. The woman was transported to a local hospital for treatment of her injuries.
The involved officers have been placed on administrative leave, which is standard procedure.
At the time of this release, the investigation is underway, and investigators are still on scene. An update news release will be issued tomorrow (Thursday 2/6/2014).
Persons who have information about this incident are encouraged to call Detective Jeff Kay at (805) 385-8174.
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Chuck Wagon at CHUCK-A-RAMA - Logan, Utah USA
in Covered Wagons
Chuck Wagon at CHUCK-A-RAMA - Logan, Utah
posted by: The_Simpsons
location: Utah
date approved: 8/4/2011
last visited: 8/4/2011
Pioneer Covered Wagon – Sioux Center, IA
This old wooden covered wagon is on display at Heritage Village historical grounds to show the main method of transporation when this part of our region was first being settled.
posted by: wildernessmama
location: Iowa
date approved: 7/17/2011
last visited: never
Pivovarský vuz / Brewery wagon - Plzen, Czech republic
Starý povoz v areálu plzenského pivovaru Pilsner Urquell / Old wagon in the area of Pilsner Urquell Brewery
posted by: Arne1
location: Plzensky kraj, Czech Republic
date approved: 7/7/2011
last visited: 4/20/2015
Covered Wagon - Laketown, UT
A covered wagon in a yard across the street from the Post Office in Laketown, Utah.
posted by: Chasing Blue Sky
date approved: 6/15/2011
last visited: 7/12/2011
The Carriage Hall Covered Wagon - Lagoon's Pioneer Village - Farmington, Utah
Located in the Carriage Hall Museum.
posted by: Lord Mot
last visited: 7/11/2011
Covered Wagon - Blountstown, FL
A covered wagon located along Highway 20 on the western edge of Blountstown, Florida, USA.
posted by: Marine Biologist
location: Florida
Covered Wagon @ Souties Bakery - North Salt Lake City, Utah
Located on Highway 89
date approved: 5/31/2011
last visited: 9/19/2011
Pioneer Casino Covered Wagon - Laughlin, NV
This covered wagon is one of many 'rustic' items on display around this casino.
posted by: ChapterhouseInc
location: Nevada
last visited: 4/7/2012
Conestoga Wagon - Naperville, IL
A reproduction of what a wagon looked like in 1830.
posted by: Go Boilers!
location: Illinois
date approved: 5/9/2011
last visited: 3/11/2012
Covered wagon in front of former coaching inn, Chrudim, Czech Republic
Old renovated covered wagon as in front of former "Blue Star (Modrá hvezda) coaching inn in Chrudim.
posted by: vraatja
location: Pardubicky kraj, Czech Republic
Pioneer Covered Wagon - Salt Lake City, Utah
Located in the Church History Museum The Church of Jesus Christ of Latter-Day Saints in Salt Lake City Utah.
posted by: Mom the Cook & cashnhubby
last visited: 4/14/2016
Kanesville Tabernacle Covered Wagon - Council Bluffs, IA
This beautifully preserved covered wagon is on display in the Kanesville Tabernacle Visitors Center.
posted by: beta59
date approved: 4/18/2011
last visited: 2/18/2012
Dickinson County covered wagon, Spirit Lake, IA
This incredibly well preserved covered wagon is showcased on the front lawn of the Dickinson County Museum for everyone to enjoy.
date approved: 3/3/2011
Gardner's Village Covered Wagon - West Jordan Utah
This covered wagon is Gardner's Village 1100 West 7800 South West Jordan Utah
date approved: 1/28/2011
last visited: 2/12/2016
Covered Wagon - Continental Divide, NM
One of many notations of the elevation, the wagon is at a gift shop.
location: New Mexico
date approved: 11/4/2010
last visited: 2/5/2014
Covered Wagon - Mountain Home, Idaho
A covered wagon along the walking path.
posted by: redheadsrule
location: Idaho
date approved: 10/20/2010
Covered Wagons - Virgin UT
Two covered wagons in Virgin UT
posted by: kJfishman
date approved: 9/17/2010
last visited: 8/10/2014
Hat Creek Ranch - Hwy. 97, BC
Covered wagon at entrance to historic site.
posted by: The 2 Newlyweds
location: British Columbia, Canada
date approved: 8/29/2010
last visited: 9/4/2016
Covered wagon, Benson, AZ
A covered wagon in Benson, AZ
posted by: TucsonThompsen
location: Arizona
date approved: 6/4/2010
last visited: 7/12/2013
"Greenhorn Creek" Covered Wagon - Farmington, CA
A covered wagon along Hway 4 in Farmington, CA.
posted by: saopaulo1
location: California
date approved: 5/13/2010
last visited: 5/14/2010
Covered Wagon - Great Basin Adventure Park - Reno, Nevada
This covered wagon is a sheep wagon. This is located in the Great Basin Adventure park. There is a fence around the covered wagon to prevent it from being damaged.
posted by: GT.US
date approved: 5/9/2010
Covered Wagon - Hampton Inn, Flagstaff, AZ
A small covered wagon outside a Hampton Inn & Suites on the west end of Flagstaff.
posted by: Rayman
date approved: 4/14/2010
Chuckwagon- Simi, CA
Cattle drive chuckwagon in front of great Old Santa Susana Cafe.
posted by: calgriz
date approved: 1/26/2010
last visited: 7/21/2014
Benson Museum Covered Wagon - Benson, AZ
Covered wagon behind the Benson, Arizona History and Arts Museum.
posted by: linkys
date approved: 12/25/2009
Pikes Peak or Bust Covered Wagon - Rock Ledge Ranch, Colorado
A classic covered wagon with the classic pioneers' slogan on it "PIKES PEAK or BUST"
posted by: Big B Bob
location: Colorado
date approved: 11/23/2009
last visited: 6/22/2014
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Our Large Corporate Tax group can help your company maximize the R&D credit.
Michael Hadjiloucas
Is Your Company Maximizing Its Tax Benefit from the Research Credit?
Corporations often view efforts to develop new products, improve legacy products, or enhance outdated and costly processes merely as a cost of doing business. As a result, these businesses may be overlooking a potential tax benefit.
What is the research tax credit?
The research tax credit was enacted as a provision of the Economic Recovery Tax Act of 1981 as a key component of a multi-faceted tax reduction package to ensure future economic growth. The credit is in addition to the tax deduction for research expenses and the benefit results in a dollar-for-dollar reduction of the business' income tax liability.
What is qualified research?
Qualified research must:
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Expenses included in the credit computation are in-house salaries and wages of employees engaged in qualified research, as well as costs of materials, supplies and certain time-sharing costs for computer use in qualified research. In addition, 65% of amounts paid to third-party contractors for conducting qualified research are eligible for the credit.
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ANAHEIM, CALIF. - John Smoltz might rejoin the Braves' rotation if Atlanta finds another closer.
"I think it depends on what we do here," manager Bobby Cox said Saturday. "But I'm not saying right now whether he's going to be in the bullpen or the rotation.''
Cox ruled out moving Smoltz unless a new closer is signed.
"We could piece it together, maybe, but I think that anybody that's going to be in contention would rather have an established closer who's been doing it," Cox said.
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Waltz from The Sleeping Beauty: 1st Violin
1st Violin
String Orchestra
1st Violin. Composed by Peter Ilyich Tchaikovsky (1840-1893). Arranged by Leland Forsblad. Classical. Part. 2 pages. Published by Alfred Music - Digital Sheet Music (AX.00-PC-0000202_VN1).
Item Number: AX.00-PC-0000202_VN1
This extremely tasteful arrangement of one of the world's most beloved waltzes will make an excellent addition to your orchestra library. Careful attention to detail makes this an unusually fine transcription. (Grade 3)
About Digital Downloads
Digital Downloads are downloadable sheet music files that can be viewed directly on your computer, tablet or mobile device. Once you download your digital sheet music, you can view and print it at home, school, or anywhere you want to make music, and you don't have to be connected to the internet. Just purchase, download and play!
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|News & Events
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Q2 2004 Ultra Clean Holdings Earnings Conference Call
|Copyright 2004 by Ultra Clean Technology. All Rights Reserved.
We specialize in meeting customers' needs through a combination of careful analysis and specialized design services. Our highly-skilled technical staff is one of the most experienced gas panel design teams in the industry. We provide a full range of services, from redesigning existing systems to the creation of completely new designs to meet customers' specifications.
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Schiano Is Back In Tampa After Emergency
Tampa Bay Buccaneers coach Greg Schiano stayed behind after yesterday?s loss to the New England Patriots, to attend to a family medical emergency.
Apparently, things have resolved themselves quickly.
According to Alex Marvez of FOX Sports, Schiano was back in the office in Tampa this morning.
Rephrased @TBBuccaneers update: HC Greg Schiano back in the office after missing team flight home from Pats game to stay w/ill family member— Alex Marvez (@alexmarvez) September 23, 2013
Source: Darin Gantt, Pro Football Talk


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Upstate News
Darryl Geddes 315 464-4828
Upstate named to research network to create database on healthcare reimbursement
SYRACUSE, N.Y.— Upstate Medical University is one of four upstate New York academic institutions named as part of a research network that will create and develop a new healthcare database for consumer reimbursement and a new Web site where consumers can compare prices before they choose doctors.
Leading the work of the research network will by FAIR Health Inc., a new not for profit company that will be headquartered at Syracuse University. In addition to Upstate, other members of the research network are SUNY Buffalo, Cornell University, University of Rochester.
"FAIR Health and the upstate research network headquartered at Syracuse University will bring much-needed transparency, accountability and fairness to a broken consumer reimbursement system we have called Code Blue," said Attorney General Andrew M. Cuomo. "By transforming this system for consumers nationwide, New York proves its reputation as a reform leader for the nation. By spending almost $100 million in settlement proceeds from health insurers, this initiative will also create new jobs and contribute to the development of the upstate economy that is vital to New York. Today is a win for consumers, New York and the nation."
Upstate Medical University President David R. Smith, M.D., said, "We are pleased to participate in this collaborative research project. The accurate processing and analysis of health claims data is extremely important within the healthcare industry."
The announcement, made Oct. 27, arises from a wide-ranging investigation by Cuomo's office into how the health insurance industry reimburses consumers for out-of-network health care charges. The investigation uncovered a fraudulent and conflict-of-interest ridden reimbursement system affecting millions of patients and their families and costing Americans hundreds of millions of dollars in unexpected and unjust medical costs.
In addition to creating and managing the new database, FAIR Health and the upstate research network will design a new consumer Web site where, for the first time, patients around the country can find out in advance how much they are likely to be reimbursed for out-of-network health care services in their area. Information in the new database will be made available for academic research, and the database itself, in non-industry hands for the first time, is expected to make FAIR Health a significant driver in health care reform efforts.
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Cabinet Expansion After Dasara
By Express News Service
Published: 28th August 2014 06:00 AM
Last Updated: 28th August 2014 04:24 AM
BANGALORE: KPCC President G Parameshwara's insistence on a deputy chief minister's post is likely to push Cabinet expansion till after Dasara.This means ministerial aspirants will have to wait till the first week of October.
Some aspirants, scheduled to fly to the US to attend a Kannada meet, met Chief Minister Siddaramaiah to ask whether they should cancel the trip in the wake of reports that he will expand the Cabinet after the Ganesha festival. Sources quoting the CM said he had advised them to go ahead as the expansion would happen only after the Dasara festivities were done on October 4. The reason for the delay is said to be Parameshwara's refusal to accept anything less than the Deputy CM's post. The CM is not conceding the position, wary of creating a second power centre.
The party will now ask AICC chief Sonia Gandhi to intervene since the two leaders aren't budging.
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Requests for Reprints: Marguerite A. Neill, MD, Division of Infectious Diseases, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860.
Current Author Addresses: Drs. Neill, Opal, Mayer, and Heelan, Ms. Cassidy, and Mr. White: Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860.
Dr. Giusti: Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20814.
© 1991 American College of PhysiciansAmerican College of Physicians
Objective: To determine the efficacy of ciprofloxacin therapy in eradicating convalescent fecal excretion of salmonellae after acute salmonellosis.
Design: Randomized, placebo-controlled, double-blind trial of ciprofloxacin, with prospective follow-up of nonparticipants.
Setting: An acute care community hospital experiencing an outbreak of salmonellosis.
Patients: Twenty-eight health care workers developed acute infection with Salmonella Java; 15 participated in a placebo-controlled trial of ciprofloxacin, beginning on day 9 after infection.
Interventions: Eight patients were randomly assigned to receive ciprofloxacin, 750 mg, and 7 patients to receive placebo; both were administered orally twice daily for 14 days. Nonparticipants who received therapy were placed on the same ciprofloxacin regimen.
Measurements and Main Results: Study participants had follow-up stool cultures every 3 days initially and then weekly for 3 weeks; nonparticipants were followed until three consecutive cultures were negative. All eight ciprofloxacin recipients showed eradication of S. Java from stool cultures within 7 days of beginning therapy (compared with 1 of 7 placebo recipients), and their stool cultures remained negative up to 14 days after discontinuing therapy (P < 0.01). However, 4 of 8 relapsed; their stool cultures became positive between 14 and 21 days after therapy. In addition, 3 of 3 hospitalized patients treated with ciprofloxacin who did not participate in the controlled trial also relapsed. Thus, the total relapse rate was 7 of 11 (64%; 95% CI, 31% to 89%). In 4 of these 7 patients, relapse was associated with a longer duration of fecal excretion of salmonellae than that of the placebo group. Relapse could not be explained on the basis of noncompliance, development of resistance, or presence of biliary disease.
Conclusions: Despite its excellent antimicrobial activity against salmonellae and its favorable pharmacokinetic profile, ciprofloxacin at a dosage of 750 mg orally twice daily had an unacceptably high failure rate in patients with acute salmonellosis and may have prolonged fecal excretion of salmonellae. The late occurrence of relapses indicates the need to obtain stool cultures up to 21 days after therapy to document fecal eradication in acute salmonellosis.
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Adapting to Evolving Business Environments Is...
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Fibroblast activation protein (FAP) expressed by some cells that surround cancerous tumors promotes tumor growth in mice, according to scientists at The Wistar Institute. Genetically deleting or therapeutically targeting FAP reduced the rate of tumor growth, they add.
Their findings were published online November 16 in The Journal of Clinical Investigation. The paper is titled "Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice." The Wistar team focused on fibroblasts and pericytes in stromal cells. Pericytes are important to the function of the new blood vessels that develop in tumors. Fibroblasts synthesize components of the extracellular matrix, and those associated with tumors also express FAP, a protease that cuts up other proteins. FAP is expressed in 90% of all human epithelial cancers and is recognized as a marker for cancer growth, according to the researchers. FAP's mechanism of action, however, had previously been unknown.
"Our data clearly demonstrates that FAP indeed promotes the growth of colon cancer as well as lung cancer in animal models and provides insight into how FAP works," says senior author, Ellen Pur, Ph.D., a professor in the molecular and cellular oncogenesis program at Wistar.
To explore how FAP promotes tumor growth, lead author, Anglica Santos, Ph.D., and colleagues took two approaches: genetic deletion and pharmacologic targeting of FAP to determine the effects of deactivating FAP in mouse models of lung and colon cancer.
First, they examined the genetic deletion of FAP. In collaboration with Wistar assistant professor and co-author Joseph Kissil, Ph.D., they mated mice engineered to spontaneously develop lung cancer when their K-Ras gene is activated with mice whose FAP gene had been deleted to develop a new strain of mice with a genetic deletion of FAP and expressing an activated K-Ras gene.
The Wistar team found that lung tumor growth was substantially inhibited in these mice. In another experiment the investigators transplanted colon cancer cells into FAP-deficient mice and saw a similarly marked inhibition of tumor growth.
"We found that FAP inactivation disrupts the organization of the collagen fibers, which are a key component of the matrix, and could be critical for many things including cell-to-cell communication, cell-matrix interactions, and development of new blood vessels to feed the tumors," Dr. Pur says. "The organization or architecture of the matrix is important to supporting both stromal and cancer cells within a tumor. If stromal cells depend on this matrix for structural support and to communicate with the cancer, they can't do that properly if it is drastically modified, as we observed in the absence of FAP activity. "
To explore the potential for a therapeutic approach, the investigators used a novel peptide agent PT630 to shut down FAP activation in the lung and colon cancer mouse models. Again, they found a significant reduction in tumor growth by inhibiting the enzymatic activity of FAP with this candidate drug agent.
"This proof of concept is the first step toward the clinic," Dr. Pur says. "We need more drugs that target the noncancer cells in tumors, which can then be combined with specific chemotherapies and biologic drugs to attack both the tumor and its supporting cells."
One of the benefits of such a strategy, Dr. Pur adds, is that a limited number of agents would likely be required to treat many different cancers because stromal cells tend to have common properties and share expression of the FAP protein in most tumor types.
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Janet McTeer on Her Oscar Nomination, Playing 'Bonkers' in The Woman in Black, and Channeling Liam Neeson for Albert Nobbs
He "has this barrel chest, and a real sense of confidence."By Jennifer Vineyard
He "has this barrel chest, and a real sense of confidence."By Jennifer Vineyard
No one ever said looking like an old-timey drag king came easy. Well, maybe they did, but Glenn Close would likely agree to disagree.By Eliot Glazer
And a few of his worsts, as well.By David Edelstein
Vulture's West Coast editor, Claude-Brodesser Akner, traces the lineage of Albert Nobbs.By Jillian Goodman
Who thinks they could pass for the opposite sex?By Adrienne Gaffney
It's her big Oscar contender.By Kyle Buchanan
Exactly ten years before, she was leaving the festival after trying to raise money for 'Nobbs'...on Sept. 11.By Jada Yuan