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Phillips Tourmaline Monster Vent Brush
- Overview
- Features
- Tourmaline core promotes healthy shiny hair
- Minimizes electricity
- Reinforced bristle
- Fully vented to maximized airflow
- Raised rubber grips for greater control
- About the brand
Phillips Tourmaline Monster Vent Brush is a top professional brush that comes in 3 1/2", 4-1/2", and 5" diameter, reinforced bristles set in a hardwood handle with rubber grips.
Based in Ohio, the Phillips Brush company has been creating professional hair brushes for over 60 years. Phillips Brushes use the latest technologies and materials for extraordinary styling results.
Handle BrokeI have medium-thick curly hair and at first I was pretty excited about this brush. But halfway through my blow dry the rubber part of the handle came loose, so I couldn't rotate the brush properly. I realized after I switched back to my old brush that I had been pulling the Phillips rush really hard to get the brush through my hair, so maybe this type of brush is only for fine hair. The was very narrow and it was uncomfortable to grip.Apr 10, 2016KateHAIR TYPECurly Hair
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Great Brush!I loved my wood Phillips 5" Monster Brush (maroon version) but part of it broke when I dropped it so I replaced it with this one and I love this brush! The handle is much improved with a rubber grip that makes it much easier to handle. The natural bristles on this brush also grip the hair so I can get the straightening/smoothing I need. However this 5" round tourmaline brush is definitely larger than the previous 5" wood version. It's HUGE. My hair is wavy, somewhat curly and has gotten very frizzy. It's just a bit longer than shoulder length with some layers. This brush, along with some product definitely solves the frizz/curly issue - my hair is straight and smooth after using it (along with some product for straight hair and some hair oil). I mostly dry my hair with a paddle brush upside down, then section and use this brush for the finishing. Sectioning is the trick with this brush, rotating and blowing hot as the hair goes around the bristles until it's smooth. My length hair only gets a small amount of bend with this huge brush (think Jessica Alba bob) but I'm thinking of also getting the 4.5" version for some added bend on the ends of my long side bangs and the layers they blend into. I don't need to use a flat iron and if I want to, it's only a quick pass through to get that flat iron super straight glossy look.Dec 29, 2015Leslie
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Too Big To Handle,I have long curly hair. Trying to blow it out with this brush was very difficult for me. Maybe okay if someone else was blowing your hair dry, but hard to grab the hair and roll it under. Handle was comfortable. I will keep it and try ,try again.Jul 3, 2013Phyllis / DelawareHAIR TYPEMedium Brown / Curly Hair
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subset: commoncrawl


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SAVE THE DATE: The 2016 New Sheriffs Institute will be held December 4 – 9 at the FSA Training Center, 2617 Mahan Dr., Tallahassee.
FSA's New Sheriffs Institute, held every four years following elections, is a continuing resource for sheriffs and their employees to research different aspects of a Sheriff's Office operations.
The most recent New Sheriffs Institute was held December 2 – 7, 2012 in Tallahassee, Florida at the Doubletree Hotel downtown.
If you have questions about the NSI, please email us.


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Top Definition
You Fucking Didiot! Why Would You Do Such A Stupid Thing?
de Profe Tonta 21 Ianuarie 2005
Trending Now
Can you define these popular missing words?
a dumb idiot
I can't believe Sally fell for that line! She is such a didiot!
de Zillionaire Z 17 Octombrie 2008
Someone who exhibits two times the stupidity of a normal idiot
"Did you see her grade on the last test?"
"Yeah, she got a 4%, she's a didiot"
"Yeah, she got a 4%, she's a didiot"
de Moo00oo00oo00 15 Aprilie 2009
the crossover of being both dumb as fuck and being a complete idiot
bob-whats 10 plus 1
bob- you fucking didiot
bob- you fucking didiot
de TextileSmartass 15 Noiembrie 2014
Some who is dumber than an idiot. Also used for a shortened version of dumber than an idiot.
Those D'idiots! Only someone dumber than an idiot would horseplay while running on the edge of a cliff!
de chocolatejavgrl14 21 Iunie 2012
did the idiotic thing
the extreme of an idiot will be an didiot.
de r1verside 27 Septembrie 2009
its a person being a dick and a idiot at the same time. cheryls are the original didiot.
erin:"Your such a didiot!"
de hipopotamus fishy 03 Februarie 2011


text: Three charges are fixed to an x, y coordinate system. A charge of +18 μC is on the y axis at y=+3.0m. A charge of -12μC is at the origin. Las, a charge of +45 μC is on the x axis at x = +3.0m. Determine the magnitude and diretion of the net electrostatic force on teh charge at x = +3.0m. Specify the direction relative to the -x axis


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Topic: 2014 South by Southwest Interactive
PHD's Millennials Talk About Their Generation on Vine
Inside the media agency's smart program
By Christopher Heine on Mar. 25, 2014 - 6:00 AM EDT
The marketing world desperately wants to know how to reach millennials, so it seems ingeniously simple that media shop PHD partners with the University of Georgia's Grady College of Journalism…
GroupMe Joins Foursquare in Skipping SXSW
No more free grilled cheese, folks
By Christopher Heine on Feb. 28, 2014 - 4:48 PM EST
While South by Southwest Interactive is expected to be a marketing extravaganza next weekend, it's becoming clear that prominent members of tech's Who's Who have other plans. "We're not holding any…


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CookieCrazie's Week in Review
My college students are back to school.
Everyone else is back to work......
and I've gotten a chance to bake and decorate cookies this week.
I love winter......snow, being cold.....therefore needing to
snuggle in a soft blanket and drink something warm.
But for whatever reason......our winters are not much different than the rest of the year. :(
This week I tried to encourage the season with snowmen, snowflakes, a sled, etc..... to no avail. : /
It is in the 50s today. Sigh......
Oh well.....next week I'll move to Valentines Day cookies and see what happens. :)
Sure.....I decide to build a snowman inside when it's a balmy 57 degrees outside.
I had no idea it was crazie to celebrate winter in January! Sigh.....
Even though it is NOT wintry outside, this little guy skates
happily inside his own little winter wonderland. :)
Last CookieCrazie chatter....


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Smooth-rolling 700c wheels give Cypress a swift yet stable feel. A suspension seatpost takes the edge off bumpy streets. And a lightweight aluminum frame provides a comfortable, upright ride for maximum efficiency and control. It's everything you need to enjoy the ride.
For more information on the Gateway to Adventure line up click here.


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UNECE Project Explores Algae Biomass Production
14 July 2010: The UN Economic Commission for Europe (UNECE) is providing assistance in identifying opportunities to introduce algae biomass production in the Russian Federation through a project on the development of sustainable biomass trade and export opportunities.
The project, launched in September 2008, aims at the development of regional biomass action plans (RBAPs) in selected regions, to help the private sector and regional governments develop a coordinated approach to foster the integration of the regional biomass sector with the forestry, agricultural, electricity, municipal heating, waste and recycling sectors. The project has so far promoted a variety of initiatives in the use of biomass, including the conversion of boiler houses for municipal district heating to the use of biomass and the introduction of cofiring of biomass in coal-fired power plants.
The project is now to explore opportunities for the introduction of algae biomass production as part of its work to introduce RBAPs, which is expected to increase the number of regions that can be involved and give a new impetus for regional governments to work on capacity building, cooperate with the private sector and make further investments in the development of the biomass sector. [UNECE Press Release]


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The right corset creates cleavage. But be realistic! If you are an A cup, don't expect by tightening your waist that you will look like a C cup girl. No, it will not happen.
With the right corset however (corsets come in different shapes and styles) you can create the illusion of being a full A or B cup girl. Corsets are capable of creating cleavage and a very feminine and mysterious look, even from a boyish looking upper body.
This is funny and interesting! In the 1920's, when being flat was beautiful and in style, women with fuller breasts actually used corsets, called a pipe-shaped corset, to flatten their bosoms.
So, yes! Corsets can also make you flat like an ironing board and that is why it is important to figure out which style is best for you.
Why will a corset create cleavage?
It is pretty simple if you take a look at this picture. Corsets are made to cinch your waist. By doing that it simply pushes your hips down and pushes your upper body, including your breasts, upward.
The extra volume of weight is "molded" into a "funnel", so you will end up with a cleavage.
Nowadays corsets are comfortable compared to those that were worn in the 18th and 19th century.
A well made corset will make you slimmer by 2-4 inches (5-10 cm) but it is still nothing compared to the old days when 6 inches (15 cm) or above was normal.
Women suffered serious medical problems, such as fractured livers, lungs, and stomachs if they had laced their corsets to tight.
On the other hand, they had no other option. A loose corset was a sign of a "loose" woman. Who would want that title...?
Here are a couple of pictures of corsets starting with the Victorian style and followed by the S-shape Edwardian style. Hmm... none of them looks too comfortable.
Corsets were gone by the end of 1920s and it took 60 years when Madonna brought it back into style again.
The corsets made nowadays will make you feel tight, however they will not mold your body into an unnatural and unhealthy shape.
OK. They are not the most comfortable things on Earth but you will want to wear them on special occasions anyway.
A full corset (or also called an over the bust corset) will make you look fuller but it also depends on the style.
A corset can tighten you up so much that if you look at yourself from the side, you will look a little bit flat.
On the other hand, looking at your breasts from the top, you will see more cleavage.
Lots of women use a little extra padding to get even more cleavage and this helps so they don't look as flat from the side.
If you have a chance to get a custom made corset, they will sew the padding in. However make sure not to over do it because you will look fake and too much padding shows!
For everyday wear, choose a sexy bustier top instead.
From Full Corset to Under Bust Corset.
Small Breasts Home Page
I have this amazing bikini above.
It will TOTALLY boost your bust with 1 cup!! :)


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The Rangers have announced that both Wojtek Wolski and Mike Rupp participated in contact drills during practice in St. Louis this morning before the team boarded a flight for Phoenix.
…and Wolski is officially out of the tub.
…while I feel confident that we'll see Rupp tomorrow night, not sure if Wolski is ready for game action yet.
…if Wolski can return next week maybe Torts will go with the Wolski-Richards-Gaborik line I was begging for all preseason.
Marc Staal also skated with the team wearing a non-contact jersey.
Remember to follow me on Twitter & Facebook or e-mail me at email@example.com.


text:
I recently purchased an SGI and I want to upgrade the harddisk and do a
reinstall at the sametime. Problem being, i dont have the original disks
that came
with it. Does anybody know where i can get them from?
If not, is there a linux or bsd port that will easily work on this system?


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Latest News
RSS feed
July 5, 2009
Air Force Scrum brings Lions home
Posted on 07/05/2009
As with the end of any tour, be it mini rugby or the international stage, this one ended with players and coaches embracing and offering thanks in one final, emotionally charged act of what has been a rollercoaster of a tour. Those fans lucky enough to share their flight did their best to catch one more memento on their cameras and mobile phones and the Lions were just as obliging as ever.
And so the curtain falls on the 2009 British & Irish Lions' tour to South Africa - a truly memorable experience. I've been lucky enough to travel the world writing about this sport for the last ten years but this was my first Lions tour. Tour veteran Brian O'Driscoll recently remarked that playing for the Lions is "like a drug" in the fact that you can't get enough and I have to say that having witnessed this latest tour at close quarters I can understand his sentiments.
There remains something special about the Lions and I wouldn't mind betting that those who question their place in the modern game have not had the pleasure of following their fortunes at first hand. The spirit of the Lions is infectious and now wonder head coach Ian McGeechan urged the doubters to embrace the Lions just once.
"I just wish more of those people who don't want to make time for the Lions would come out and actually experience a Lions tour," said McGeechan.
But it is not as if the Lions as a brand are dying. Estimates have varied but it is safe to say at least 30,000 fans made the trip to South Africa and with that kind of commercial clout the Lions will be back bigger and even better in four years time. Let us not underestimate the role played by the Lions' fans in keeping the brand alive. The Lions' shirt is often cited as the greatest prize for British and Irish players and it is that same famous red jersey that appeals to the fans. They admire the players that go into battle wearing it but they come and go through the years - it is the shirt itself, and what it stands for - the history, the tradition - that has the masses hooked.
The 2005 tour of New Zealand was a failure in many ways and although this year's quest also ended in a series defeat the latest batch of Lions managed to repair much of the damage done to their reputation on their last outing. For that, huge credit must go to McGeechan and his tour manager Gerald Davies. They promised to return the Lions to their traditional roots and they did just that - and in doing so made new friends and repaired strained relationships.
I hope you have enjoyed the insight I have been able to offer and that you too have been bitten by the Lions bug. The Lions are back and I for one can't wait for Australia in 2013.
Lions Tour 2009 Awards:
Player of the Tour: Brian O'Driscoll
Moment of the Tour: Ronan O'Gara's second Test cameo
Rising Star: Heinrich Brussow
Try of the Tour: Shane Williams, Lions v South Africa
Tackle of the Tour: Jean de Villiers, South Africa v Lions
Quote of the Tour: "I don't think it should have been a card at all."
July 4, 2009
Lions left to rue what could have been
Posted on 07/04/2009
OK - this was a second string South Africa side but it contained many of the form players from this year's Super 14 with a point to ahead of the Tri-Nations. This game was also being played at Ellis Park where only one side has claimed victory against the Boks in the last 12 years - a record they are rightly proud of. And the brawl that broke out in the closing stages of the game may well have been a sign of the home side's frustration at that record being tarnished.
What we saw today was the result of some McGeechan magic. The Lions veteran has once again shown his exemplary man-management skills to get this whole squad pulling together towards the same goal. They failed in their quest for a series victory but they dug deep and despite the many changes the hunger was still there. McGeechan indicated that this may well be his last Lions tour (including this year he has played on two tours and coached on five others) but don't be surprised if his name is amongst those linked with the 2013 tour to Australia.
But let us not forget that the Springboks already had the series in the bag thanks to their victories in the first two Tests. In those two games they showed just as much, and perhaps more character than the Lions showed today. Sport is a results business and the hosts produced the goods when it mattered most and should be heartily congratulated for that achievement.
South Africa chose to use today's game to protest at Bakkies Botha's two-week suspension for a dangerous charge in the second Test in Pretoria. They were incensed at what they see as the inconsistency of the judicial system that sees similar incidents go unpunished most weeks. They are right, and have received support on the matter from the Lions, but an occasion as today's match was not the place to air their grievances.
The match gave way to another contest of sorts involving the opposing fans. The aim was to make your way from one end of the pitch to the other to score an imaginary try. The problem was that fans were not allowed on the pitch and an army of stewards were there to stop them. But I'm glad to report that some did manage to escape the clutches of their would-be tacklers who at times looked as half-hearted as the Golden Lions did a few weeks ago. The score appeared to be in the Lions' favour until the stewards got their collective game-heads on but they had to rely on some reckless challenge that may have caught the citing commissioner's eye.
For the final game of the tour I had the honour of sitting next to the Daily Mail's Peter Jackson who was presiding over his last Test match before retirement. The Lions' impressive victory was a fitting tribute to his career that has spanned five decades - many of them at the frontline of the sport - and his contribution to the sport was acknowledged by head coach Ian McGeechan after the game. Enjoy retirement Peter - and thanks for keeping us both informed and entertained.
July 3, 2009
Posted on 07/03/2009
Lions prop Phil Vickery is an incredibly popular player. One look into today's press conference at the soul-less Sandton Convention Centre here in Johannesburg would have told you that. The journalists flock to his side whenever he is offered up to the media machine mainly because they know he is good value.
The 33-year-old, a veteran of 77 caps for England and four - soon to be five - Test appearances for the Lions, has seen most things in the game and has experienced both triumph and disaster. And in the words of Kipling he has managed to, "treat those two imposters just the same." Vickery, who led the Lions in their tour clash against Western Province, is honest, rarely ducks the issue and often raises a laugh or two. He knows the power of a good sound bite but is also experienced enough to know not to go too far.
This weekend sees him lock horns with South Africa's Tendai 'The Beast' Mtawarira once again after coming out very much second best in the first Test clash in Durban. When asked how he had coped with the disappointment of their encounter we got one of the quotes of the tour.
"You know you've had a **** game when you get text messages from your mum, your sister and your Mrs saying that they still love you," said Vickery.
He also offered an amusing behind-the-scenes insight into the battle that was last weekend's second Test at Loftus Versfeld and the humour within the exclusive front row club.
As 23rd man for the match, Vickery found himself in the treatment room doing his best to help fellow props Adam Jones (dislocated shoulder - thanks to a dangerous charge from Boks lock Bakkies Botha) and Gethin Jenkins (clash of heads with Boks winger Bryan Habana). Fearing he was neglecting Jenkins in favour of Jones, he crossed to speak to the Welshman whose "face was caved in" and was covered in blood and stitches. Struggling to speak, Jenkins joked, "Is Nugget [Martyn Williams] playing tight-head?"
Vickery was also confident of a stronger showing against The Beast this weekend where he hopes to exorcise some demones and settle some scores. The weight of hooker Matthew Rees alongside him and lock Simon Shaw behind him should be a huge help this time around.
Lions assistant coach Warren Gatland was also up in front of the media today and revealed that he and head coach Ian McGeechan had engaged in a positive meeting with their South African counterparts - Peter de Villiers and Gary Gold - and Saturday's referee, Stuart Dickinson, the previous night. Interestingly, Gatland had sympathy for the Springboks on the issue of Bakkies Botha's two-week suspension for his dangerous charge on Adam Jones that ended his tour. Gatland and co did not see anything wrong with that specific incident. His actions may well have been questionable but apparently no different to what is usually allowed according to the Kiwi.
Some mixed feedback regarding Naas Botha's comments on Ronan O'Gara that we ran with earlier this week. Whether you agree with him or not, the former Springboks fly-half is a charismatic figure who is not short of an opinion or two. I was lucky enough to spend some time with him after an invite from my Total Rugby colleague Martin Cross. At his home on the outskirts of Pretoria he entertained us with many stories including how he would regularly play for Northern Transvaal on a Saturday afternoon before jumping on a plane to Italy where he would turn out for Rovigo the following day - he would sometimes be forced to get changed in the taxi from the airport but more often than not would play a starring role in both games.
So here we are on the eve of the final game of the tour. Many predicted that we would reach this point with the Springboks already victorious but not one of those expected it to be so close. A total of eight points have separated the team in the last fortnight. Can the Lions rescue something from the series at Ellis Park? I hope so because they deserve something. The Springboks have been the better side but not by much and even they would find it hard to begrudge the visitors a consolation win. Time will tell how focused or generous the hosts are feeling.
July 2, 2009
Posted on 07/02/2009
He admitted he had been 'stupid' over the past few days - not for sharing his outspoken views but for reacting to some of the perceived negative reports from the British & Irish media.
"What a stupid bugger I am," he told reporters. "I've learnt that if they can't win on the field then they will try to win anywhere else they can."
De Villiers is also refusing to change his ways and did nothing to dispel the belief that he is obsessed with his own persona by referring to himself in the third person. "I won't change my style," he said. "If I change my style I change Peter de Villiers and I go back to God and say: 'You made a bad job.'"
Fascinating, amusing and sometimes troubling - but nearly always good copy. He is very much an individual which is a notable character trait but sometimes you think he is a loose cannon. The pressure of being the first black Springboks coach and to a certain extent a political appointment must weigh heavy at times.
He is blessed with an immensely talented team and his record of 11 wins in 15 internationals since taking over from Rugby World Cup winner Jake White is also impressive. But you sense that De Villiers feels he is untouchable and not even a atrocious on-field record could hasten his demise. SA Rugby chiefs are obliged to give their man time for fear of further political repercussions. His controversial comments must cause concern but at the end of the day sport is a results business and as long as his side keeps winning - and they are many people's favourites for the Tri-Nations - he will continue to have the support of his union, his team and most importantly the fans.
In a related point, SA Rugby issued a statement today clarifying the judicial ruling on Schalk Burger's eight-week ban. They were keen to stress that the flanker was cleared of eye-gouging Lions winger Luke Fitzgerald in the opening minute of the second Test but found guilty of 'making contact with the eye area' of the Irishman. The statement also included an apology from Burger to his team and their fans but not to the Lions or Fitzgerald.
De Villiers has predictably made several changes to his side for Saturday's final clash in Johannesburg with the series already in the bag. It is obvious his mind is now focused on the forthcoming Tri-Nations and his selection - and his desire to give all his players the chance to play against the Lions - does de-value the fixture to a certain extent. Perhaps they should have been allowed to play for their provinces then, apart from the Bulls' players, there would not be such an issue. However, it remains a formidable line-up - such is their strength in depth.
The Lions, ravaged by injury, will limp into the Ellis Park clash with a new-look team. Of note is Phil Vickery's return to the front row for the first time since his mauling at the hands of South Africa's Tendai 'The Beast' Mtawarira in the first Test. As a result of McGeechan's final tour selection winger Tommy Bowe (at centre for Saturday's clash), fly-half Stephen Jones, No.8 Jamie Heaslip, scrum-half Mike Phillips and captain Paul O'Connell will be the only players to have started all three Tests. How the Lions must wish that number was higher.
June 30, 2009
Posted on 06/30/2009
That incident continues to take the shine off their achievement - South Africa showed great character and mental strength in both of the opening two Tests to see off a brave Lions team and exact revenge for their series defeat 12 years ago. But instead of glowing in that success they find themselves fighting fires due to their outspoken coach Peter de Villiers.
De Villiers sparked the controversy by insisting that the Burger incident did not warrant a yellow card and that such incidents were a part of sport - "It's sport, man. This is what it's all about," he said. SA Rugby have since issued a statement apologising for any suggestion that, "acts of foul play are in any way condoned by South African rugby." But the same day that apology was issued, De Villiers was again defending the actions of his player and denying the incident took place.
It seems no one has the power to silence De Villiers or at least get him to tone down his opinions. There is an argument that he is bringing the game into disrepute and the suggestion that eye-gouging is part of the game is simply horrifying. That one statement could do irreparable damage to a sport that is trying to boost participation levels at grassroots level and also make a bid for Olympic re-inclusion.
Lions centre Brian O'Driscoll made a very telling point - "Kids or parents watching an interview like that, questioning whether they should have their kid play rugby or soccer, that's their decision made right there."
SA Rugby are going to be under increasing pressure from the International Rugby Board is they are unable to silence their coach.
I was sent some interesting facts on the back of Burger's latest indiscretion courtesy of my Scrum.com colleague Huw Richards.
Saturday's yellow card was Burger's first on the international stage for four years and 32 matches. He also holds the record for the most yellow cards in international rugby with his latest being his sixth - coming in his 50th match. His latest yellow card saw him edge past Italy's Marco Bortolami on that particular unwanted rugby record.
He collected his previous yellow card against Ireland on June 12, 2004, then on consecutive weekends against Wales and Ireland that November, against France on June 25, 2005 and Australia on July 23, 2005 - in other words in the space of 15 matches and little over a year.
The Lions' communications team (and their South African counterparts) have been incredibly helpful throughout the tour but their attempt to keep the media machine well fed during two days of media inactivity had us giggling.
The release in question offered the following hold-the-front-page sound bites:
"On Monday we went on an early game drive, jumped in the truck, grabbed a blanket and were driven round. We saw all sorts of animals, the hippos in the water, elephants, warthogs, zebras, a hell of lot of impala and deer and the backside of the elusive Lion!" - Tom Croft
"The safari was amazing, to actually see the elephants and the Lions up close and then right at the end to actually get in the cage with the Lion was one of the best moments of the tour." - Ugo Monye
"The safari was brilliant fun." - Ross Ford
Thankfully the void was filled by Brian O'Driscoll who decided to give De Villiers both barrels for his controversial comments.
June 28, 2009
Posted on 06/28/2009
The Lions' fans were again magnificent. The estimated 25,000 in the stadium more than held their own – and a special mention for the Zulu War uniform-clad group who greeted the Springboks off the team bus with a stirring version of Men of Harlech. Psychological warfare - great stuff.
The game itself was such a brutal encounter one journalist asked whether the modern game was too physical – an interesting question for the Lions to consider as they pick through the remains of their squad ahead of the final clash in Johannesburg.
There were some crunching tackles – none more so than that of Lions centre Brian O'Driscoll on Springboks replacement Danie Rossouw. The two staggered away like punch-drunk heavyweights with the towering Rossouw coming over all Bambi-like before hitting the deck. The warrior that O'Driscoll is, he refused to acknowledge the pain or the fact that he had been concussed and tried to carry on – but it was not long before he had to make way.
The Burger alleged gouging incident did not make for pretty viewing. It occurred under the noses of the media ranks and was greeted with widespread shock by journalists on both sides of the divide – partly because the Stormers flanker is not a dirty player. He walks a fine line like all good back row forwards but this was out of character. The citing commissioner has called him to explain his actions and it is likely he will be handed a heavy ban.
As I have said elsewhere on the site, it was a shame for such a thrilling game had to include such an unsavoury incident. With the first capacity crowd of the tour and a worldwide audience of millions it was perhaps even more of a shame to see the scrums reduced to uncontested with the game not even an hour old. When such a pivotal part of the game is reduced to a farce it must send alarm bells ringing at the International Rugby Board. Law changes allowing for extra front row replacements cannot be too quick in coming.
Springboks coach Peter de Villiers all but denied the alleged eye-gouging incident took place in his post-match press conference with his attitude drawing gasps and even laughter from some quarters. And he appeared to be getting himself into a corner before his skipper John Smit intervened and asked everyone to move on and leave it to the citing commissioner. Smit could perhaps see his coach hitting the headlines for all the wrong reasons again.
The Lions management face a huge task to lift their players now as they bid to avoid the whitewash. It is all very well saying that the famous red jersey will be all the inspiration they will need but I fear it will need something extra.
June 26, 2009
Posted on 06/26/2009
That bizarre experience was the prelude to a fantastic day touring the sprawling township on the outskirts of Johannesburg - an experience I highly recommend. Our trip took in the Hector Pieterson and Apartheid Museums, the soon-to-be-completed Soccer City stadium being built for the 2010 Fifa World Cup and into the heart Orlando East - one of township's suburbs. It was an intense history lesson and you'll be able to read more about my visit soon.
The previous evening I was lucky enough to catch some of Confederations Cup semi-final clash between Brazil and South Africa at Ellis Park. I've never known an atmosphere like it and Bafana Bafana did their passionate supporters proud with a brave display. Daniel Alves' late strike broke the hearts of the majority of the 50,000 crowd but did not silence the vuvuzela horns. This Saturday's second Test between the Lions and the Springboks at a capacity Loftus Versfeld in Pretoria should provide an interesting contrast and I'll be sure to let you know all about it.
Following my social study at Ellis Park I can now offer the following guidelines for supporting Bafana Bafana:
Vuvuzela - You either love them or hate them but if you are serious about supporting Bafana Bafana you have to have one of these plastic horns.
Makarapa - Pimped-up hard hats. A homage to the country's mining roots and the more elaborate they are the better.
Over-sized sunglasses - The bigger the better and preferably yellow.
South African flag - Another must-have. Can also be painted onto your person.
Ability to dance - Not only when you score but on the spot continuously for a full two hours.
Bafana Bafana shirt - Worn back-to-front to show your player allegiance to the TV cameras.
Mobile phone - To ensure you waste time getting a blurry and muffled souvenir from the game rather than just soaking up the atmosphere.
Optional extra:
Nelson Mandela mask - Bring your own bit of 'Madiba magic' to boost your team.
June 25, 2009
Posted on 06/25/2009
The sun will also be welcomed by the Lions when they eventually return to the Highveld but with that joy will be tempered by the prospect of playing the most important game of their lives at 1400m above sea-level.
Put simply, playing at altitude makes breathing harder as the thin air means there is less oxygen available.
The issue has troubled most touring teams in South Africa and the Lions are no different. Lions fly-half Ronan O'Gara memorably summed up the debilitating effects of playing at altitude following the opening clash with the Royal XV in Rustenburg.
"I felt like an imbecile in that first match," he said. "I certainly underestimated the effects of altitude. The mind was telling me one thing but the body wouldn't get me into the position to do it."
As with every other aspect of this tour, the Lions management and medical teams have put months of preparation into this part of the tour. And reports suggest that England football coach Fabio Capello has already sought their advice ahead of next year's Fifa World Cup.
The Lions' preparations were to include a training camp in Spain where conditions would be similar to those they would face here in South Africa but that was subsequently scrapped. Instead the players were encouraged to use altitude simulators - adding a sci-fi element to their pre-tour build-up at their leafy Surrey base.
"The Lions will discover the difference when their chests start burning," warned Springboks skipper John Smit earlier this week but perhaps he as unaware that the Lions have continued their altitude training whilst at sea-level thanks to the high-tech equipment available to the fitness team. One such training method requires players to wear a mask connected to a machine that limits oxygen intake.
The Lions have played their last five games at sea-level in Cape Town, Port Elizabeth and Durban and have chosen to prepare for the must-win second Test in Cape Town before flying up to Johannesburg on Friday - the day before the game.
Experts say that ideally you need eight days preparation at altitude to combat the effects but the Lions' schedule did not allow for that. The alternative is to travel up at the last possible moment - as the Lions are doing. The science behind this approach says that the somewhat crippling effects do not then have a chance to kick in.
Only time will tell if the Lions have got their preparation just right. But of course, the altitude issue is just one factor - albeit a major one.
The teams for the Pretoria showdown have both been announced with South Africa opting for only one change. Schalk Burger returns to the Springboks' line-up for the unlucky Heinrich Brussow who drops to the bench. However the Lions, who must win the game to keep their feint hopes of a series victory alive, have opted for a little more surgery with five changes including a first Test cap for veteran lock Simon Shaw.
South Africa have only lost three of their last ten clashes at Loftus Versfeld - all to New Zealand - and England were the last northern hemisphere side to upset the odds back in 1994.
The odds are really against the Lions and the first sell-out of the tour suggests that the home fans are confident of seeing their side complete the job.
June 24, 2009
Posted on 06/24/2009
The rain, cold temperatures and gale-force winds has me longing for the sun and the balmy temperatures of Durban - and the blanket coverage of a sun-drenched SW19 on the various sports channels available here is not helping matters.
Denied the chance to return to Robben Island or climb Table Mountain due to the inconsiderate weather, I accepted an invite to South Africa College Schools (SACS) to catch some junior action ahead of the Newlands clash. SACS, the oldest school in South Africa, was playing host to Kings Hospital School from Dublin and both sides did their best in what were atrocious conditions. A 5-5 draw was a fair result by all accounts but I must admit I was driven under cover long before the final whistle.
It was heartening to see another bumper crowd at Newlands, bolstered by the thousands of Lions fans who remain committed to the tour. They braved the elements with the kind of enthusiasm we have come to expect from the Lions' loyal following. I guess when you have paid several thousand pounds for the chance to be here you are not going to let the small matter of the end of he world spoil your fun.
But the Lions' fans were unable to inspire great things from their team. Despite the demoralising draw at the hands of the second string Boks, the Lions did their best to remain positive after the game but a citing for lock Nathan Hines will not have helped the mood in the camp.
Luckily, I am escaping the gloom here in Cape Town ahead of the Lions who are due to remain here until Friday. The bad news for them is that the weather shows no signs of breaking up before the weekend which is sure to hamper their preparations for the second Test.
Meanwhile, the Springboks are basking under the sun in Jo'burg where conditions will not be a million miles away from those at Loftus Versfeld in Pretoria - that will stage the pivotal Test clash on Saturday.
June 22, 2009
Posted on 06/22/2009
His medical updates, peppered with his favourite phrase 'in good fettle', are quite a draw due to the entertaining insight they offer into the foibles of the players - e.g. Lee Byrne likes his troublesome foot strapped a certain way - and his assessment of players under his care - "I'd like to stick a needle in his backside sometimes...He's a complex individual who is a bit like Austin Healey, is phenomenally talented and sometimes a bit irritating but I love him to bits." - The player in question? Byrne again.
When pressed on his admiration of Healey, Robson continued, "I think Austin was one of the most talented players I have ever worked with" - Cue sigh and rolling of the eyes from Healey's ex-Leicester and England team mate Rowntree and much laughter.
His latest epic briefing included the longest answer we have seen on tour. One of my colleagues from the BBC asked for some clarification on the rulings on concussions, as that recently suffered by James Hook. A full FOUR AND A HALF MINUTES of detailed explanation later he was only stopped by a round of applause!
"And if you want a more detailed answer see me after," he joked.
Robson's contribution was more than a fitting introduction to Rowntree's honest remarks about the Lions' showing against the Springboks the day before. He acknowledged that they had been second best and the players, in particular the forwards, would be 'very disappointed' when they reviewed the tapes themselves.
Before I left Durban I squeezed in a visit to Paul Flanagan in nearby Port Shepstone. The well-travelled former hooker, who had a spell at Ballymena, now runs a rugby academy. It was an all-too-brief trip but I got a great insight into some great work he is doing - stay tuned for more details.
While tour fatigue maybe setting in for some, it obviously isn't for others. I over-heard this conversation on my flight from Durban.
Lions Fan #1: "Do you find you're having to pace yourself drinking-wise?"
Reports in Monday's papers backed up the assumption that the Lions' travelling support have a mighty thirst.
Under the headline, "Lions fans drink pubs dry" Barbara Cole of the Cape Argus wrote:
"Emergency beer supplies had to be trucked in to pubs in Durban and Umhlanga to cope with the demand from Lions fans.
The report continued: "It was absolutely unbelievable. We were just not prepared for the onslaught," said a delighted Eleanor Gilles, manager of The George Tapas and Wine Bar. "The Lions drank us dry twice on Friday and I had to close the doors at midnight as we had run out after getting a re-supply at lunchtime."
Good old Brits abroad.
Another story I stumbled upon over the weekend centred on the subject of empty seats. There was a bumper crowd in at Kings Park for the opening Test but there were still plenty of unsold tickets.
It appears that such was SA Rugby's concern about the possible embarrassment that would accompany swathes of empty seats at the game that they were out amongst the local clubs on Friday night handing out free tickets. One source told me that at their game - all the matches were switched to Friday to enable fans to watch the Test - someone was handing out tickets by the handful.
The potential public relations disaster obviously triggered some desperate moves from officials but they are not the only ones under pressure. Fifa continues to press South African officials over the empty seats at Confederations Cup matches while the crime issue is looming as an even bigger problem with Brazil the latest to suffer at the hands of thieves.
I was greeted by rain on my return to Cape Town and the morning gave way to a grey, damp and miserable picture from my hotel. The forecast is for more of the same which my hinder any plans for an expansive game from either side on Tuesday night.


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Our four-year-old colt Strings and Arrows will be entered for a NY-bred maiden special weight at Aqueduct for Saturday, March 13th, going one  ile and 70 yards.  The racing office put the race up as an extra after a couple of two-turn races for Strings and Arrows failed to draw enough entries, and so we had to run him at six furlongs, a lot shorter than his best distance.  If the race goes, this will be his third start suince returning from an injury, and we'll be looking for a strong performance.
Castle Village Farm trainer Bill Turner is being honored this weekend by the Barbados Turf Club, as the only living trainer of a US Triple Crown winner (Seattle Slew in 1977). Bill's visit is in conjunction with Barbados' biggest racing day of the year, the 29th running of the Sandy Lane Gold Cup, on Saturday, March 6th.
Bill will be back at Palm Meadows in Florida, training our colt Iguazu, by the end of the weekend.
Castle Village Farm racing manager Steve Zorn writes regularly on the business of thoroughbred racing. It's an iconoclastic view of the game we all love, definitely not the same-old, same-old view that's usually repeated by industry insiders. You can check it out here: http://businessofracing.blogspot.com or by clicking on the Blog tab on our home page.
Our four-year-old colt Strings and Arrows, making his second start off a seven-month layoff, ran a solid 4th in Aqueduct's 7th race today, gaining ground through the stretch. The race was at six furlongs, which is shorter than we wanted, but NYRA hasn't been using any two-turn maiden races for older horses. So we entered here and got a solid performance that reinforces our belief that Strings and Arrows will do better as the distances lengthen out. In any event, Aqueduct had a huge speed bias today, so our colt's closing effort was even more impressive.
Castle Village Farm's four-year-old colt Strings and Arrows, by Bowman's Band, makes his second start following a seven month layoff when he goes to the post on Saturday, Deb. 20th, in Aqueduct's 7th race. It's a New York-bred $50,000 maiden claiming race, at six furlongs on Aqueduct's inner track. Jockey Mike Luzzi will ride for trainer and co-owner Leah Gyarmati.
Our four-year-olds based at Belmont, Talking Blues (trained by Bruce Brown) and Strings and Arrows (trained and co-owned by Leah Gyarmati) are both ready to race again. All they need now is for the NYRA racing office to cooperate. Both were targeting races in the condition book for this week, but neither race was used. So we're watching the overnights and looking for the next available spots.
Our three-year-old colt Iguazu is back at work at the Palm Meadows training center in Boynton Beach, Florida. This past Saturday Iguazu breezed a half-mile in 48.50 seconds, the 6th fastest of 24 works at the distance that day.
Iguazu came out of the breeze in excellent shape and is back galloping on the track. He'll have a few more breezes and then we'll be looking for a race for him.
Both Talking Blues and Strings and Arrows have bounced back from their last starts, and we're looking for them to be racing again in the next week or two.
There's a race in the condition book for Talking Blues on February 7th, and one for Strings and Arrows on February 11th. Â In each case, it'll be at the same level as their last outings, non-winners-of-two for Talking Blues, and NY-bred maiden special for Strings and Arrows. Entries for both races will be taken later this week.
The new Castle Village Farm 2010 claiming partnership is actively looking for a horse, with hot New York trainer Bruce Brown. Â There's still time for new partners to get involved, and to become part of the search for our horse. All claiming partners get regular updates on each day's card at Aqueduct, evaluating possible horses to claim. Just check our New Partnership Opportunities.
Talking Blues wheels right back from his convincing 5 1/2 length maiden win on New Year's day and is entered in the 5th race at Aqueduct on Sunday, January 17th. It's a field of nine going a mile and 70 yards in a non-winners-of-two-lifetime claimer. Once again, Rosie Napravnik will ride for trainer Bruce Brown and Castle Village Farm.


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Hello again race fans. It appears the weather is going to cooperate this weekend and we can get back to racing. It seems like forever since we have raced at Port Royal and Selinsgrove speedways. That should happen tonight.
Port Royal Speedway has the premier sprint car show of the weekend. Guy Webb's All Star Circuit of Champions invades the Juniata County oval tonight for the Bob Weikert Memorial race. Webb's group is led by Knoxville Nationals winner Tim Shaffer of Aliquippa. The steel city outlaw should be joined by Dale Blaney, Greg Wilson and others.
Local drivers that signed up for the All Star eastern championship also should be in the field. The eastern title pays the winner $20,000. There's plenty of money and contingency awards available to racers. The 30-lap A main pays $7,100 to win. With bonus money for heat races, fast time, lap money, etc., a clean sweep could earn the winner $10,150.
I've been told that Richard Childress chose car No. 29 to replace car No. 3 after Dale Earnhardt's death in part because of his relationship with the Weikert family. Childress also has agricultural interests, which include cattle and a winery. The Weikerts and Childresses have done business with each other and RCR Racing is one of many sponsors of tonight's race.
Money has been added through the week so who knows where it will stop. Tyler Walker will pilot a Weikert's Livestock-painted Keen racing car in the event. Walker's driving style would have suited Bob Weikert just fine. Fans have a chance to go home with some goodies as well. Bicycles will be given away to kids and packages of meat will be handed out. Weikert did that many years ago and that promotion was a huge success. I'm sure it will be well received tonight. Action gets under way at 7.
The sidewinder sprints and pro stocks also are part of the show.
Bob Weikert was one of a kind and fans either loved or hated him as a car owner. There was no middle road. Weikert's best years came during the Doug Wolfgang era with Davey Brown and Fred Grenoble turning the wrenches.
Weikert would wind up the crowd with his boastful comments. But it wasn't really bragging because Weikert's teams could back it up. Grenoble went on to be featured with Weikert on the now-defunct Nashville Network's "Hidden Heroes" series, which brought more national attention to our area's racing. Weikert and Al Hamilton, along with other local car owners, did as much to put local racing on the map as anyone. Both hired the best drivers. Notable drivers that ran well for Weikert included Kenny Weld, Paul Pitzer, Keith Kauffman, Bobby Davis Jr. and Randy Wolfe. Tonight we honor one of the all time greats.
At Selinsgrove Speedway the pro stocks take center stage with a 20-lap feature. The 358 sprint cars, late models and roadrunners are also in action starting at 7.
Lincoln Speedway is racing 410 and 358 sprint cars plus thundercars tonight at 7.
Williams Grove Speedway hosts another Saturday night special $5 general admission show this evening. Susquehanna Speedway will be in action tonight with a regular program as well.
Clinton County Speedway is now open for Friday night action.
Hagerstown Speedway hosts the steel block bandits late model series tonight. Rick Singleton was looking forward to competing with that series with car owner Sam Barley. I spoke to both during each of Port Royal Speedway's 2011 late model events.
Barley was proud of Singleton's driving ability and the pair meshed well. Singleton was up beat after two top 10 finishes at the Juniata County oval despite his car weighing 400 pounds more than the super late models he ran against. I'm sure Singleton's plans are under review.
Barley unexpectedly passed away this past Sunday at his Bellwood home. He was 73. Some of you will remember him as Johnny Grum's brother-in-law, who accompanied him to the races when Grum drove the Harry Fletcher-owned No. 66 sprint car. Barley passed from apparent heart problems, for which he was to have undergone some type of procedure this past week. Barley never made it that far.
He was a good guy who will be missed by many in the racing community, especially those of us that have been around the sport most of our lives. He will not be forgotten.
Craig Rutherford writes about motorsports for The Sentinel.


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New Music Documentary Project, Greatest Hits, Crowdfunding on Seed&Spark
If you are receiving this message multiple times today, thank you for your repeated support of my projects and my career. Your support truly means a lot to me. If... Read more
Abel and Cain Gets a Little Bit of Academic Attention
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Abel and Cain Online December 2nd
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A New Project
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Another New York Screening 7/17!
Tomorrow night Abel and Cainwill be screening in New York at the IndieWorks Screening Series from CongestedCat Productions. Part of the screening includes a Q&A with the panel of... Read more
Abel and Cain Screening June 13th at Brooklyn Short Film Festival
I just received word that Abel and Cain has been accepted to the Brooklyn Short Film Festival. The screening is June 13th at the Galapagos Art Space in DUMBO. Doors... Read more
June 12 6:30PM Anthology Film Archives
Just a reminder for any of you in and around New York. Come and see the film with me. You made it possible. Come and let me give you an... Read more
Happy Anniversary
A year ago today I posted this Kickstarter project. 11 months ago you awesome folks funded it. Happy Anniversary!
Today I put the DVDs and Producer Packages + DVDs in... Read more
First Rewards Sent!
If you selected one of the backer rewards, a few moments ago you should have received a message from me via Kickstarter with a link to download the final... Read more
Shooting Wrapped!
Last night we wrapped shooting for Abel and Cain. I've been looking through our last day of footage this morning and I'm really excited to get to work on putting... Read more
Thanks to our awesome backers, our friends who didn't disown us for constantly talking up the project, and all our supporters across the electric world of the internet we made... Read more
47 Hours to Go, Let's Keep it Going!
We're closing in on the last hours of the campaign here and I'm really pleased to say that we're still going strong. As I write this we're at $3700 and... Read more
100% and Building!
Yesterday we hit 100% on our campaign. That means we can make Abel and Cain and all of us on the team can't emphasize enough how much we appreciate the... Read more
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Snakes in Trees: Mythology in Abel and Cain
Ever since I was a kid, I've loved mythology. The stories we tell to make sense of the world around us, I've always been a big fan of them. Who... Read more
10 Days and less than $1300 to go! Enjoy this backers only peek at a first cut of the film's mysterious video
The Halfway Mark! New Reward Levels! More Stuff Coming!
Today is the halfway mark for our campaign and we're at 55% funded as of my writing this. We've been keeping a good pace, but we still have a ways... Read more
Video Update from Tara and Alex
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Have you considered working on a large ship and to get training for a job at sea? If so, you have the opportunity of trying out whether life at sea is in your taste.
We take interns from business schools on board our beautiful passenger ships for the following positions: Ship's Officer Student and apprentice chef.
Apply here


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Sheldon's Adventure: Cornered!
By Intense Media, LLC
Open iTunes to buy and download apps.
"Sticks and stones will break my bones but names will never hurt me!" Sadly, being called names DOES hurt, and being bullied makes kids feel sad and lonely. Sometimes it helps to have someone remind us that we are all special in our own way, and sometimes, we just have to find out for ourselves.
Cornered! Is the story of a little green turtle named Sheldon; a curious turtle who likes music, sports, and eating flies. In fact, he's pretty normal except for one little thing; his shell is square and not round. And all Sheldon wants more than anything is to fit in and look like every other turtle. But because he looks different, all the kids tease him and call him names. Sheldon's mom tries to tell him his four cornered shell is a gift but he's not buying it. One day he has to do one of the bravest things he's ever done and he realizes that who he is on the inside is what really matters. Sheldon's brave deed saves the day and he learns quickly that being a little bit different can be a very good thing!
• This is the second book in a series of books about self-esteem and bullying
• Filled with animations and interactive buttons for your child to discover
• Includes "real" swings that act and sound like swings
• The one time your child will be allowed to draw on the school's walls
• A shell-changer with an endless selection of shells to try on
• Real sound FX
• A fireworks show
• And a loveable and adorable character that you'll just want to hug!
Customer Reviews
Sheldon is a touching character who kids could relate to when they are bullied. Please give him a helmet instead of a cap when he rides his skateboard. Many of the interactive features are clever; some appear to be random. We enjoyed the musical soundtrack.
Current and relevant
Side note: Sheldon looks so much like..... (I think his name was) ....Sheldon! Via "Sherman's Lagoon!"
Customers Also Bought
- $1.99
- Category: Books
- Released: Dec 10, 2012
- Version: 1.0.0
- Size: 77.9 MB
- Language: English
- Seller: Nick Nebelsky
- © 2012 Intense Media, LLC
Compatibility: Requires iOS 4.3 or later. Compatible with iPhone, iPad, and iPod touch.


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Author Affiliations:University of California, San Diego, La Jolla (Drs Fleisher, Raman, Sherzai, and Thal and Mss Becerra and Sowell); Eli Lilly & Co, Indianapolis, Indiana (Drs Siemers and Dean); Departments of Neurology, University of Pennsylvania, Philadelphia (Dr Clark), Indiana University School of Medicine, Indianapolis (Dr Farlow), and Oregon Health Science University, Portland (Dr Quinn); Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri (Dr Galvin); University of Washington, Seattle (Dr Peskind); and Georgetown University, Washington, DC (Dr Aisen). Dr Aisen is now with the University of California, San Diego.†Deceased.
To evaluate the safety, tolerability, and amyloid β (Aβ) response to the γ-secretase inhibitor LY450139 in Alzheimer disease.
Multicenter, randomized, double-blind, dose-escalation, placebo-controlled trial.
Community-based clinical research centers.
Fifty-one individuals with mild to moderate Alzheimer disease were randomized to receive placebo (n=15) or LY450139 (100 mg [n=22] or 140 mg [n=14]), with 43 completing the treatment phase.
The LY450139 groups received 60 mg/d for 2 weeks, then 100 mg/d for 6 weeks, and then either 100 or 140 mg/d for 6 additional weeks.
Main Outcome Measures
Primary outcome measures were adverse events, plasma and cerebrospinal fluid Aβ levels, vital signs, electrocardiographic data, and laboratory safety test results. Secondary outcome measures included the Alzheimer's Disease Assessment Scale cognitive subscale and the Alzheimer's Disease Cooperative Study Activities of Daily Living Scale.
Group differences were seen in skin and subcutaneous tissue concerns (P=.05), including 3 possible drug rashes and 3 reports of hair color change in the treatment groups. There were 3 adverse event‐related discontinuations, including 1 transient bowel obstruction. The plasma Aβ40concentration was reduced by 58.2% for the 100-mg group and 64.6% for the 140-mg group (P<.001). No significant reduction was seen in cerebrospinal fluid Aβ levels. No group differences were seen in cognitive or functional measures.
LY450139 was generally well tolerated at doses of up to 140 mg/d for 14 weeks, with several findings indicating the need for close clinical monitoring in future studies. Decreases in plasma Aβ concentrations were consistent with inhibition of γ-secretase.
Trial Registration
clinicaltrials.gov Identifier: NCT00244322
LY450139 is a functional γ-secretase inhibitor that is currently under development as a disease-modifying therapy for Alzheimer disease (AD). As reported previously, LY450139 rapidly reduces amyloid β (Aβ) concentrations in the brain, cerebrospinal fluid (CSF), and plasma of transgenic V717F human amyloid precursor protein mice (PDAPP mice)1,2and in the plasma of humans.3In addition, the administration of LY450139 at doses of 30 mg/kg once daily for 5 months to PDAPP mice results in reduced accumulation of Aβ in the hippocampus and cortex, as measured by means of enzyme-linked immunosorbent assay.4Previous clinical studies using LY450139 with either healthy volunteers5or patients with AD6have shown short-term reductions in plasma Aβ40levels up to approximately 40% using single daily doses up to 50 mg. A single-dose escalation study3using 60, 100, or 140 mg in healthy volunteers demonstrated a dose-proportional increase in drug levels in plasma and CSF and a dose-dependent reduction in plasma Aβ levels.
The tolerability of LY450139 treatment in clinical studies of up to 50 mg for 2 weeks5or 40 mg for 6 weeks6was generally good. However, concern exists about cumulative toxic effects that may not be revealed in short low-dose trials or higher single-dose biomarker studies. A potential cause of clinical toxic effects for γ-secretase inhibitors is the inhibition of Notch cleavage by these compounds.7Notch cleavage is integral to cell differentiation pathways in many organ systems, including the gastrointestinal tract and lymphoid cell lines. To our knowledge, the effect of multiple-dose administration of 100 and 140 mg of LY450139 in patients with AD has not been reported previously.
In this study, we aim to demonstrate the safety and tolerability of LY450139 over 14 weeks using single daily doses of 100 and 140 mg. We sought to determine whether extended exposure to these higher doses of LY450139 would be tolerated and would result in expected changes in plasma and CSF Aβ levels.
Fifty-one patients were enrolled at 6 academic research centers between October 1, 2005, and December 31, 2006. The protocol was reviewed and approved by the institutional review board at each participating site. All research participants and caregivers gave written informed consent. The Alzheimer's Disease Cooperative Study's Data Safety Monitoring Board, which is advisory to the National Institute of Aging, provided oversight on an ongoing basis.
Participants were 50 years or older and diagnosed as having probable AD, as defined by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer Disease and Related Disorders Association criteria.8Individuals receiving stable doses of cholinesterase inhibitor drugs or memantine were included. Patients were excluded if they had a history of irritable bowel syndrome, chronic diarrhea, peptic ulcer, or gastroesophageal reflux disease; a history of cardiac disease; significant electrocardiographic (ECG) abnormalities; hematologic disorders; hepatic or renal disease; active malignancy within 5 years; or clinically important depressive, neuropsychiatric, cerebrovascular, or respiratory disease.
This is a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial (Figure 1). Participants were randomized to receive LY450139 or placebo using a 2:1 randomization scheme via a telephone-based interactive voice-response system. Patients randomized to the LY450139 groups received 60 mg/d for 2 weeks, then 100 mg/d for the next 6 weeks. At 8 weeks, the treatment arm was randomized again to receive 6 additional weeks of treatment at either 100 or 140 mg/d. Dose reductions were allowed for dose-limiting adverse events (AEs) during the treatment phase.
Protocol schema.
All AEs occurring during the study were characterized. Safety data, such as vital signs, ECG data, and laboratory test results, were collected throughout the trial. Vital signs were recorded at each study visit, with ECGs performed at baseline and at weeks 2, 4, 8, 10, 14, and 16.
Routine hematology and clinical chemistry laboratory tests were performed at screening; at weeks 2, 4, 8, 10, and 14 (treatment); and at a 26-week follow-up visit. Measurements of CD4, CD8, CD19, IgG, IgA, and IgM cells were obtained at baseline, treatment end, and the 26-week follow-up visit. T-cell function was assessed by means of flow cytometry.3Urinalysis was tested at screening and at weeks 8 and 14. Stool samples were tested for occult blood at each study visit after baseline. Optional DNA testing for apolipoprotein E subtype was performed.
Plasma samples for measurement of biomarkers and drug levels were collected at baseline and at weeks 14 and 16. At week 14, multiple samples were collected in 6 hours for pharmacodynamic modeling (30 minutes before and 0.5, 1, 2, 4, and 6 hours after receiving the drug). The CSF samples were collected into polypropylene tubes by means of a lumbar puncture at baseline and approximately 6 hours after the administration of the last dose of LY450139 at week 14.3Plasma and CSF concentrations of Aβ were measured from all the samples,3and concentrations of LY450139 were measured from all the samples after baseline.5
At baseline and at weeks 8 and 14, assessments were made of cognition and daily functioning using the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog 11)9and the Alzheimer's Disease Cooperative Study Activities of Daily Living Scale (ADCS-ADL).10
Adverse event data are reported using intention-to-treat analyses (n=51) across 26 weeks, with a completers analysis for all comparisons of laboratory and clinical measures through week 14 (n=43). To maximize the sensitivity of the safety measures, no adjustments were made for multiple comparisons. All statistical tests were 2-sided. P<.05 was considered statistically significant for biomarker and clinical measures, and P<.10 was used for safety variables to indicate potential clinical significance. All analyses were performed using the R statistical package, version 22.214.171.124
Data from all randomized participants for 26 weeks were included in the safety analyses. The Fisher exact test was performed to assess group differences in proportions of participants reporting specific types of AEs and serious AEs.
Analysis of covariance (ANCOVA) was used to assess 14-week change scores in all efficacy and biomarker outcomes of interest, with treatment group as a factor. Significance was based on the overall Fstatistic for interactions among all 3 treatment arms. Baseline values of outcome measures were entered as covariates into each model to account for any baseline group differences. In addition, any variable found to have significant between-group differences at baseline and to correlate with the outcome measure being tested was entered as a confounder into a post hoc ANCOVA model. Outcome variables included vital signs, laboratory measures, Fridericia-corrected QT intervals, log mean CSF Aβ40and Aβ42measures, and ADAS-Cog 11 and ADCS-ADL scores. A 2-way ANCOVA was used to investigate whether the treatment effect on the change in ADAS-Cog 11 scores was modified by donepezil hydrochloride therapy. Post hoc Bayesian estimates were used to determine pharmacokinetic variables.5At week 14, mean change in LY450139 and absolute mean plasma Aβ levels were compared for each time point over 6 hours using Kruskal-Wallis nonparametric tests of means.
Of 71 participants who were screened for the trial, 51 were eligible and randomized. Forty-three participants completed the treatment phase of the trial (Figure 2). No differences existed in dropout rates (84%) or medication compliance (96%-99%) among the 3 groups.
Data flowchart for the 26-week trial. The intention-to-treat analyses included all 51 patients originally randomized, including all subsequent dropouts. The completers analyses included the 43 patients who completed the week 14 visit.
The 3 groups were balanced at baseline regarding all demographics, clinical measures (except Mini-Mental State Examination [MMSE] scores), apolipoprotein E ε4 distribution, and acetylcholine esterase inhibitor and memantine use (Table 1). Differences in baseline laboratory values are given in Table 1.
All AEs that occurred in 2 or more participants are given in Table 2. Only the category of skin and subcutaneous tissue disorders reached significance for differences between groups (P=.05). In this category, there were 3 possible "drug-related" rashes and 3 reports of hair color change (lightening) in the treatment groups, with none in the placebo group. Although not reaching statistical significance, the percentage of patients reporting nausea, vomiting, or diarrhea was 27% in the treatment groups and only 13% in the placebo group (P=.41). In addition, when combining reports of somnolence, fatigue, lethargy, and asthenia from different organ classes, we found that 40% of treatment subjects noted 1 or more of these symptoms, whereas only 13% in the placebo group had these symptoms (P=.18). There were 4 serious AEs (Table 3). A small-bowel obstruction was considered to be possibly related to the study drug; no medical intervention was required, the study drug was discontinued, and the obstruction resolved spontaneously.
Eight participants dropped out of the trial during the treatment phase because of AEs (n=3), personal conflict (n=3), physician decision due to difficulty in managing increasing agitation and paranoia (n=1), and a protocol violation consisting of a patient reporting a history of gastroesophageal reflux disease after randomization (n=1). The AEs included diarrhea, heme-positive stool (required dropout per protocol), and the previously described bowel obstruction. There were 3 site-initiated dose reductions for rash, abdominal discomfort, and nausea.
Between-group differences were seen in some safety laboratory value changes during the therapy phase (Table 4). None of these changes were considered clinically important based on the degree of change and the lack of associated adverse events. No statistically significant group differences existed in mean change in the ECG Fridericia-corrected QT interval over 14 weeks. The 140-mg group showed the greatest numeric change, with a prolongation of 19.3 milliseconds (4.80%) compared with an increase of 2.8 milliseconds (0.69%) in the placebo group (P=.18).
At week 14, a rapid increase in plasma drug levels was seen after drug administration (Figure 3). Peak plasma levels occurred at 1.26 hours (t½=2.23 hours) for the 100-mg group and at 1.68 hours (t½=2.59 hours) for the 140-mg group. A CSF sample could not be obtained for 1 participant in the 140-mg group. Six hours after drug administration at week 14, the 100- and 140-mg groups had mean (SD) CSF drug concentrations of 77.4 (34.3) ng/mL and 102.1 (30.3) ng/mL, respectively (Wilcoxon rank sum P=.02).
Changes in arithmetic mean plasma LY450139 concentrations over 6 hours at week 14. Error bars represent SD.
At week 14, just before drug administration, absolute mean plasma Aβ40levels were increased by a mean (SD) of 32.0% (34.6%) in the 100-mg group and 35.2% (60.6%) in the 140-mg group compared with study baseline (Kruskal-Wallis P=.009) (Figure 4). No statistically significant elevations were seen in Aβ42levels.
Change in absolute mean plasma amyloid β 40 (Aβ40) concentrations after administration of LY450139 at week 14. Error bars represent SD.
After drug administration at week 14, mean plasma Aβ40levels declined rapidly in both treatment groups (Figure 4). Concentrations decreased significantly below baseline by hour 2 for both treatment groups (P=.02), and they continued to decline up to 6 hours after administration (P<.001). The maximum reduction in Aβ40concentration was 58.2% for the 100-mg group and 64.6% for the 140-mg group (Figure 4). No statistically significant difference in Aβ40reduction existed between the 100- and 140-mg groups. During this 6-hour period, 14 of 36 treated participants had 1 or more plasma Aβ42measures decline below the lower limit of quantification measured by means of enzyme-linked immunosorbent assay (28.0 pg/mL), making these data statistically noninterpretable.
No significant reductions were seen in mean log CSF Aβ40(F=2.025, P=.15) or Aβ42(F=0.73, P=.49) levels in the full ANCOVA model. Percentage changes from baseline in absolute means are presented in Figure 5. Spearman rank correlations showed a trend association between CSF drug levels and percentage change in CSF Aβ concentration in the 140-mg group (Aβ40: r=–0.51, P=.09; Aβ42: r=–0.51, P=.09) but not in the 100-mg group (Aβ40: r=–0.35, P=.17; Aβ42: r=–0.20, P=.44). Change in absolute CSF Aβ levels showed trend associations with drug levels for the 140-mg group (Aβ40: r=–0.43, P=.17; Aβ42: r=–0.55, P=.07) and the 100-mg group (Aβ40: r=–0.47, P=.06; Aβ42: r=–0.21, P=.42).
Change in absolute mean cerebrospinal fluid (CSF) amyloid β 40 (Aβ40) and Aβ42levels between baseline and week 14. MMSE indicates Mini-Mental State Examination.
No significant differences were seen in ADAS-Cog 11 (P=.36) and ADCS-ADL (P=.63) scores after 14 weeks of treatment among any of the 3 groups (Table 5). This lack of treatment effect was not modified by the inclusion of donepezil use in the ANCOVA model.
The MMSE score was the only variable found to be a confounding measure. The 3 treatment groups differed at baseline on MMSE scores, with a possible relationship found between baseline MMSE scores and change in CSF Aβ40concentrations (Spearman ρ=0.30, P=.06). An ANCOVA model including MMSE score as a covariate revealed a trend toward significant reductions in CSF Aβ40levels at week 14 compared with study baseline in the treatment groups compared with the placebo group (F=2.90, P=.07) (Figure 5).
This longitudinal study in elderly patients with AD was necessary for assessing safety and possible Notch-related toxic effects, which would not likely be revealed by single-dose studies.12Notch toxicity encompasses many of the drug-related tolerability concerns for γ-secretase inhibitors.13Notch is a transmembrane protein that plays a role in nuclear signaling, and, similar to the amyloid precursor protein, it seems to be cleaved by a presenilin-dependent γ-secretase complex.7It plays an important role in programmed cellular death. Organ systems with rapid cellular turnover have, therefore, been the primary concern for Notch-related toxic effects. Both gastrointestinal and immune cell functions have been altered in preclinical studies with LY450139 (data on file, Eli Lilly & Co). To our knowledge, no previous human study of LY450139 has demonstrated clinically significant toxic effects on the immune system.3,5,6Diffuse macular rash on the extremities and torso and hair color changes in some participants were likely the result of treatment with LY450139. However, no evidence existed of other toxic effects associated with these. The rash and the hypopigmentation were reversible. Gastrointestinal symptoms, somnolence and asthenia, and ECG changes were not statistically significantly different between groups, yet they should still be considered potentially important drug-related AEs given the known mechanism of action of this drug and the limited statistical power of this study.
As shown in Figure 4, the plasma level of Aβ40is higher than the study baseline level before drug administration at visit 14. In a previous single-dose study,3a biphasic response of plasma Aβ to LY450139 was observed at 60, 100, and 140 mg, with an initial reduction in plasma Aβ concentration followed by an elevation higher than baseline levels 8 to 10 hours after administration. Doses of 100 mg or greater prolonged plasma reductions and reduced plasma elevations over 24 hours compared with 60 mg.3Similar patterns of peripheral changes in Aβ levels have been seen in preclinical studies14of guinea pigs with LY450139 and in studies of other γ-secretase inhibitors.15However, similar increases in CSF and brain Aβ levels have not been demonstrated in previous preclinical studies of LY450139 at multiple intervals after drug administration up to 24 hours (data on file). In addition, studies using very low doses of LY450139 showed increased plasma Aβ levels without a period of reduction.5,14Thus, 1 possible explanation for a transient increase in plasma Aβ concentration is that in peripheral, but not in central, tissue(s) γ-secretase inhibitors have a stimulatory effect on the enzyme at low concentrations that is overcome by the inhibitory effects at higher concentrations. Although steady-state Aβ reductions would be desirable, twice-daily dosing is not possible owing to observed Notch-related toxic effects in multiple organ systems in preclinical studies of Fischer 344 rats and dogs (data on file, Eli Lilly & Co). The clinical implications of this are unclear.
The expected clear changes in CSF Aβ levels were not demonstrated in this study despite robust reductions in plasma Aβ40and dose-related LY450139 concentrations in the CSF. Correlation analyses between CSF drug levels and Aβ levels suggest a pharmacodynamic response but perhaps lack statistical power. In preclinical studies, CSF Aβ-lowering effects have been seen in PDAPP mice1and dogs (data on file, Eli Lilly & Co). Lack of CSF changes in the setting of clear serum changes may reflect rapid transport of Aβ from CSF into plasma and a lengthened period for Aβ to reach equilibrium in the CSF. In a trial15of a similar γ-secretase inhibitor, changes in CSF Aβ concentration lagged behind changes in plasma Aβ concentration, with significant decreases seen at 12 hours. One study16demonstrated that carbon 13‐labeled Aβ levels did not reach equilibrium in lumbar CSF until approximately 13 hours after the beginning of the infusion. In the present study, Aβ levels were measured approximately 6 hours after morning drug administration. Longer periods may be required to identify CSF changes. Furthermore, transgenic PDAPP mice,1wild-type mice,1and guinea pigs14show a clear association between the reduction in plasma and brain Aβ levels after the administration of LY450139. Whether CSF changes in Aβ concentration can be detected in people with AD after oral administration of LY450139 requires additional studies.
The long-term efficacy of this drug is not known. Given the slow rate of clinical progression in AD, we did not expect to see drug effects on measures of cognition or ADLs in this 14-week trial. Without this, a full risk-benefit assessment cannot be made. This trial sufficiently demonstrates that LY450139 can be tolerated, although not without risk. Given the potential for disease-modifying effects of this Aβ-lowering agent, and the arguably acceptable tolerance and safety profile of LY450139 demonstrated in this study, further large-scale efficacy trials are justified. Based, in part, on the results of this phase 2 study, Eli Lilly & Co launched a multinational phase 3 trial in the second quarter of 2008, with an enrollment goal of 1500 patients with AD.
Correspondence:Adam S. Fleisher, MD, University of California, San Diego, 8950 Villa La Jolla Dr, Ste C227, La Jolla, CA 92037 (email@example.com).
Accepted for Publication: April 11, 2008.
Author Contributions:All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Fleisher, Siemers, Dean, and Thal. Acquisition of data: Fleisher, Siemers, Clark, Dean, Farlow, Galvin, Peskind, Quinn, Sherzai, and Thal. Analysis and interpretation of data: Fleisher, Raman, Siemers, Becerra, Dean, Farlow, Sowell, Aisen, and Thal. Drafting of the manuscript: Fleisher, Raman, Siemers, Dean, Sowell, and Thal. Critical revision of the manuscript for important intellectual content: Fleisher, Raman, Siemers, Becerra, Clark, Dean, Farlow, Galvin, Peskind, Quinn, Sherzai, Sowell, and Aisen. Statistical analysis: Raman, Siemers, Becerra, and Sowell. Obtained funding: Thal. Administrative, technical, and material support: Fleisher, Siemers, Dean, Farlow, Sherzai, Aisen, and Thal. Study supervision: Fleisher, Raman, Siemers, Clark, Farlow, P eskind, Aisen, and Thal.
Financial Disclosure:Drs Siemers and Dean are employees of Eli Lilly & Co, the manufacturer of the study drug. All the study sites were subcontracted through the ADCS at the University of California, San Diego, which held the primary contract with Eli Lilly & Co. Dr Farlow has received research grant funding support from Eli Lilly & Co that was independent of and unrelated to this trial.
Funding/Support:This study was fully funded by Eli Lilly & Co. The ADCS infrastructure is supported by cooperative grant UO1AG10483 from the National Institute on Aging.
Role of the Sponsor:The study design was developed by Eli Lilly & Co in consultation with the ADCS. The study was conducted by the ADCS, with data collection, management, analysis, and interpretation by the ADCS. Manuscript preparation was completed by the ADCS in consultation with Eli Lilly & Co.
Additional Information:The ADCS had access to all the data, with full, unrestricted publication rights.
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Deborah DeWaay, M.D.
Assistant Professor
Dr. Deborah DeWaay was awarded her M.D. from the University of Iowa Carver College of Medicine in 2005 with a distinction in research. At that time, she was inducted into the Arnold Gold Foundation Humanism in Medicine Society. She completed residency training in Internal Medicine at the Medical University of South Carolina and then was Chief Resident in Internal Medicine. She has decided to continue at MUSC in General Internal Medicine as a hospitalist. In addition, she will be the Clerkship Director for students. Her interests include: medical education, curriculum development and facilitating the integration of information technology at MUSC.
Dr. DeWaay's Curriculum Vitae (PDF Format)*


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STATEN ISLAND, N.Y. -- Are you ready to snort, giggle and play with the most loveable little piggy on the block?
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The Peppa Pig collection of plush dolls, play figures, playsets, books and DVDs ranges from $6.99 to $34.99 and is available exclusively at Toys "R" Us.


text: DATE=12/5/1999 TYPE=CORRESPONDENT REPORT TITLE=PAKISTAN POLITICS (L-ONLY) NUMBER=2-256855 BYLINE=AYAZ GUL DATELINE=ISLAMABAD CONTENT= VOICED AT: INTRO: Pakistan's military ruler Genral Pervez Musharraf has promised to restore elected local governments by the end of the year 2000. The military leader, who seized power in a bloodless coup in October, says he is committed to building genuine democracy in the country. From Islamabad, Ayaz Gul reports. TEXT: The move would be the first step toward fulfilling General Musharraf's promise of giving, as he puts it, genuine democracy to Pakistan. An official statement (issued late Saturday) quotes General Musharraf as saying district-level elected governments will be in place within a year. The military leader says his government is seeking to build democratic institutions through the "devolution", or transfer, of power. In order to achieve that objective, he says electoral reforms will be introduced to strengthen Pakistan's election commission. General Musharraf made no mention of restoring the national or provincial parliaments that were suspended when he seized power in a coup October 12th. Addressing a Pakistani-American organization in the capital last Friday, General Musharraf said democracy could flourish in the country only through this "devolution", or transfer, and passing down of power to the grass roots level. //Musharraf Act// We have to devolve power down to the grass root level. We mean to the district level. We have to give power, shed power from the center to the provinces and from the provinces to the districts. The people must be masters of their own destiny. //End Act// General Musharraf holds the "elite" responsible for failing the poor majority of the country's 135-million people. A Pakistani leader has rarely made such critical remarks in the past. //Musharraf Act Two// Pakistan has been let down by the elite's. It is we all, me included. It's the bureaucratic elite, it's the industrial elite, it's the military elite, it's the religious elite, and it's the political elite. There is a mental block in our minds because we cannot act against the powerful, against the rich. //End Act// Political analysts have long blamed Pakistan's tiny "elite" of running the country for their own vested interests since it's creation in 1947. A succession of governments have done little to improve the lot of ordinary people, with an average Pakistani earning less than 50-dollars a month.(Signed) NEB/AG/PLM 05-Dec-1999 08:34 AM EDT (05-Dec-1999 1334 UTC) NNNN Source: Voice of America .


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If there's one thing that 2009's remake of '80s Canadian slasher My Bloody Valentine isn't, it's scary.
Thank goodness for us, then, that it happens to make for cheesy, corny, gimmicky, gory fun -- if only in its 3-D theatrical presentation. Director Patrick Lussier may forsake genuine suspense and tension in his quest to create an overblown small-town soap opera with no shortage of nifty kills (though they may not be enough to save the film from itself in 2-D or on DVD), but the man knows how to use today's technology to create an amplified visceral horror experience. It's low-brow entertainment with high-tech execution, and while it's anything but scary, it's also pretty much everything but scary. The film gets off to a sharp start with a fifteen-minute prologue that's both refreshingly no-nonsense in getting the blood flowing while overdone as all get out when it comes to getting the blood flowing RIGHT AT YOU! It's a mine-set massacre set on the one-year anniversary of a town-rocking mining accident -- that indeed took place on Valentine's Day -- and as the story takes up ten years after that incident, when survivor Tom Hanniger (Jensen Ackles, boasting acting chops on a rough par with Lucas Black) returns home to sell his late father's mine and simultaneously become the prime suspect in a renewed string of murders, committed by a mysterious pick-axe wielding miner. Also caught up in the homecoming/slaughter are Tom's old flame, Sarah (Jaime King), and her new husband, town sheriff Axel (Kerr Smith), and yes, for a significant portion of the film, it's like this love triangle is twisting up all sorts of long dormant emotions RIGHT AT YOU!
Generally speaking, the plot follows that of the musty 1981 original, with a couple of loving nods thrown in here and there, as scribes Todd Farmer and Zane Smith keep themselves more importantly on task by crafting any number of excuses for eye-popping, jaw-dropping (well, -ripping) kill scenes that Lussier treats ever so lovingly. Sure, he relies on CGI much more than practical effects (those are best suited for the aftermath), but he uses his visual effects as well as he does his sound work, which is to say quite well for a film focused on startles above all else, and that's not to mention composer Michael Wandmacher's surprisingly robust work on the score.
There's one scene above all others that seems particularly shameless, though not entirely tasteless, in which a most unfortunate bimbo (played by Betsy Rue, who I'm sure is a perfectly nice girl in real life) finds herself running in and around a motel in nothing but her birthday suit -- a motel, it should be mentioned, which is run by a little person (Selene Luna, being a good sport). It's a film that doesn't just employ gratuitous frontal nudity and dwarf* sight gags, but makes the most of them, which is perhaps best applied to a film that is itself nothing if not gratuitous.
While the crew may give matters their all, though, it's hard to say the same of the cast. Torn between two love interests and a killer on the loose (who may or may not be one of said love interests), King does fare best as the only character not playing it up for the cheap seats, but Ackles and Smith are CW/WB alums for a reason and are part of the reason that the midsection drags on. At first, it seems like the petty melodrama is just another part of the fun, as proudly campy as anything else on display, but even that wears out its welcome just long enough to make one pine for a bit more of the red stuff, which does come in due time. So far as 2-D and DVD exhibition go, I suspect that the second act, with its repetitive exposition and would-be characterization, will make the money shots seem significantly less impressive in context, let alone in comparison to their 3-D counterparts.
That said, as far as remakes go, My Bloody Valentine earns a rightful R rating with pride, and it raises the bar for 3-D horror fare to come. Sure, someone might eventually see fit to make a project of this ilk that tries to make the most of atmosphere and whatnot, but for now, this is about as fun and creative and indeed bloody as these things get.
*God, I hope that's the right word.
categories Reviews, Cinematical


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With only hours left, we are only $595 away from reaching our goal! Here is a quick video update filmed in St. Augustine, Florida during some time on the road.... Read more
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Update: Southfield man arrested in hotel stabbing death of his father
SOUTHFIELD, MI -- Police are investigating a homicide that took place in a Quality Inn hotel Thursday.
A 27-year-old man is in custody after a 66-year-old man was killed in an apparent stabbing around 11:20 a.m. at the Telegraph Road hotel, according to Southfield police.
(Correction: The suspect is 27 and victim 66. Police initially described the suspect as 26 and the victim as around 50)
"The suspect is in custody and there is a known relationship between the suspect and the victim," police announced.
Both the suspect and victim live in Southfield, according to police.


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A prayer vigil was held Monday to honor a 21-year-old who was shot to death in her bedroom last week.
Family and friends joined the community to remember Adreanne Evans, 21. Evans was gunned down while she was inside the apartment.
Evans' ex-boyfriend, Lagenza Junious, has been charged in her murder and for shooting her 19-year-old male friend.
Monday's vigil was held by Heeding God's Call, a grassroots organization that focuses on ending the gun violence.
Also during the vigil, organizers lit candles to honor the 26 victims of the Sandy Hook Elementary School shooting in Connecticut.


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- When:
Add This Event To YourTuesday, October 8, 2013
at 11:10 AM
- Where:
- Boe Memorial Chapel,
- Web Link:
- http://www.stolaf.edu/multimedia
- Contact:
- Lisa Brown
Daily Chapel: Mary Hakes
Today's speaker is Mary Hakes, Music Admissions Coordinator.
Daily Chapel is a time of inspiration for body, mind, and spirit; a quiet harbor in a busy day; worship. Students, faculty, and staff witness to their faith and invite the community to join them. All are welcome!
If you are unable to join us in person, but would like to watch live or archived Chapel services, please click the web link above.
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A weather pattern that seems to afflict only the drunk, often confused for earthquake and/or tornado.
Dude 1: What the hell, man, can't you stand up straight!
Dude 2: *Slurring* Nope, I'm el trasho.
Dude 2: *Slurring* Nope, I'm el trasho.
de DrunkenLawyer 14 Iunie 2007
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