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CANTON - Bill Powell, a Minerva High School graduate who was the first African American to build, own and operate a golf course, died on Thursday. He was 93.
The PGA of America said the creator of Clearview Golf Club in East Canton died at Aultman Hospital in Canton following complications from a stroke.
''Bill Powell will forever be one of golf's most unforgettable American heroes,'' PGA of America president Jim Remy said. ''Bill made us appreciate the game and each other that much more by his gentle, yet firm example.
''He was born with a fire within his heart to build on his dream. In the process, he made golf a beacon for people of all color. The PGA of America is better today because of individuals like Bill Powell. We will miss him dearly. We extend our thoughts and prayers to his family as we remember a wonderful man.''
In August, Powell received the PGA Distinguished Service Award, the association's highest annual honor. In November, he was inducted into the Northern Ohio PGA Hall of Fame and honored as the Person of the Year by the Ohio Golf Course Owners Association.
The Canton Regional Chamber of Commerce also recently presented the Powell family with its Community Salute Award.
''My father made a mark,'' said daughter Renee Powell, the second black player to compete on the LPGA Tour. ''And, I believe that God wanted people to know the mark that he made on this nation.''
Born Nov. 22, 1916, in Butler County, Greenville, Ala., Powell was the third child of six children of Berry and Massaleaner Powell. As the post-World War I economy shifted, the Powell family moved in 1919 to Minerva where Berry Powell ended his business of owning a general store and found steady work in a pottery factory.
Bill Powell discovered a love for golf at age 9 by playing and caddying at Edgewater Golf Course. As his own game developed, Powell became a multi-sport athlete at Minerva High School.
Powell was one of the star football players at his high school and was a freshman member of the 1932 Minerva team that finished the season unbeaten and unscored upon in its run to the first Tri-County League football championship. He capped his football career as a senior fullback who also saw time on defense.
While also at Minerva High School, Powell and his friends formed a golf team and he was asked by the athletic director to serve as captain and coach. That meant Powell would schedule matches against all local schools.
A grandson of slaves, Powell became a fine amateur player and was the first black to compete in a junior event at Orchard Hills Country Club (now The Fairways Golf Club) in North Canton. For two days, the 16-year-old Powell hitchhiked 42 miles round trip to the course and after having led the tournament until the final few holes, he finished third.
He later attended Wilberforce University in Xenia where in 1937 the school's men's golf team traveled to play Ohio Northern University at Lost Creek Country Club in Lima in the first inter-racial collegiate golf match in American history. Wilberforce returned home triumphant and also captured the rematch.
Powell met Marcella Oliver and they were married Nov. 22, 1940, Powell's birthday. He went on to serve in the U.S. Army Air Corps through the end of World War II where he earned the rank of Technical Sergeant in the U.S. Eighth Air Force Truck Battalion. During his service he was able to golf throughout Great Britain.
After the war, he returned to Canton where he continued working at Timken as a roller bearing and steel manufacturer. He would be employed there for 23 years.
Powell worked 18-hour days to support his family and build Clearview Golf Club. Denied a GI Loan, he found funding from two African American physicians, and his brother took out a second mortgage on his home.
Powell went on to carve Clearview out of former dairy farmland in 1946, clearing the land himself. In the process, Powell broke down racial barriers without fanfare by developing female and youth golf leagues.
Clearview opened its initial nine holes in 1948. Powell eventually repaid his benefactors to gain full ownership, and nine more holes were completed in 1978. Clearview is on the National Register of Historic Places, and nicknamed ''America's Course.''
''I didn't build this course for any of the recognition,'' Powell said in his 2000 autobiography, Clearview: America's Course. ''It was a labor of love. Golf is a part of society and I wanted to be included. I want you to be included, too. I've always felt that each individual should leave something behind of meaning. It feels good to know that I have done that with Clearview, at long last.''
Powell was also the teacher-coach of his daughter, Renee, who competed from 1967 to 1980 on the LPGA Tour and later served as a head professional at a golf club in England. Renee, who earned PGA of America membership in 1996, followed in her father's footsteps as a promoter of the game and was the 2003 PGA First Lady of Golf.
In 1992, the Powells were honored by the National Golf Foundation as the Jack Nicklaus Golf Family of the Year. That year, Powell was awarded the ''Cornerstone of Freedom Award'' from the Dr. Martin Luther King Jr. Commission.
Powell was inducted into the National Black Golf Hall of Fame in 1996, and became a PGA Life Member in 1999. Powell also received honorary Doctor of Humane Letters degrees from his alma mater, Wilberforce University, and from Baldwin-Wallace College.
Powell also played a role in The First Tee, which has distributed more than 1,100 William J. Powell Scholarships that allow youngsters to attend The First Tee Life Skills and Leadership Academies conducted on college campuses.
Powell was preceded in death by wife Marcella and son William. In addition to daughter Renee, he's survived by son Larry, who has served for more than 30 years as superintendent at Clearview Golf Club, and twin sisters Mary Alice Walker and Rose Marie Mathews.
Calling hours are set for 2 to 4 p.m. and 7 to 9 p.m. on Tuesday at Minerva United Methodist Church. The funeral will be held at 11 a.m. on Wednesday at the same location. Arrangements are through Bartley Funeral Home in Minerva.
In lieu of flowers, donations can be made to the Clearview Legacy Foundation, P.O. Box 30196, East Canton, OH 44730.


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Custom Traffic Signs
Use your own words and logos on Custom Traffic Signs to direct both pedestrian and vehicle traffic
Custom Traffic Signs let you communicate your own specific traffic safety messages. These custom signs provide warnings, give directions, state policies and promote your company. Choose from a wide variety of signs from Stop Signs to Speed Limit Signs. Add your own logo to traffic signs for your own personal touch.

subset: commoncrawl


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For learning: Hindi
Base language: English
DescriptionThis is the fifth part of my video series on learning Hindi-focusing on writing and reading. This sub-part (b) has the consonants of Hindi getting combined with the other consonants, using rather complex special symbols in its writing system (devanagari script), and our first Hindi word!. It concludes in part 5 (a). Please watch the entire parts 4a to 4b on devanagari script before this part.


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Final Score
Colts: 17, Texans: 29
The Indianapolis Colts lost to the Houston Texans on Sunday as their comeback bid fell short. The Colts looked to be leading another comeback after a touchdown pass to Dwayne Allen got the Colts within six, but penalties and mistakes stalled the rest of their offensive possessions, and they would get no closer.
With the win, the Texans clinch the division, and the Colts drop to 9-5, needing one more win to clinch a playoff spot.
Let's take a look at some final grades for Indianapolis from this Week 15 matchup.


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Get organized
Now is the time to get organized! Start learning effective money management here by designing your first budget with our step-by-step tutorial. Use the tools below for helpful information on setting your priorities; selecting a bank; saving thousands of dollars by graduating in four years; and applying for scholarship aid that, unlike loans, does not need to be repaid.
Define your priorities
Inspiration to get your financial house in order
Keep debt levels manageable
Before signing the dotted line, determine how much debt is too much
Make a spending plan
Use this roadmap and these tools to track your spending and set up a realistic, flexible plan
Plan for graduation in 4 years
Why planning to graduate in 4 years can save you BIG money
Understand financial aid
Understanding the types of aid will help in making the right decisions
Search for scholarships
You may qualify for money that never needs to be repaid
Borrow wisely
Find out how interest impacts your loan when you choose low payments over a longer repayment period
Choose a bank
What to look for in a financial institution
Store your documents
Develop a filing system that works for you


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Sydney, Australia
The first morning's session was opened by Professor Douglas Joshua, chairman of the organizing committee. Professor Joshua remarked that this meeting was the largest gathering of the myeloma community, with over 1100 delegates in attendance. The new initiatives of this meeting include concurrent plenary and focus sessions due to the vast amount of material to be covered. Additionally, this meeting is planned to include a chairman's symposia, oral presentations for abstracts, poster sessions, industry exhibitions, and industry-sponsored symposia. Professor Joshua briefly discussed the history of the meeting as a series of workshops held globally beginning in 1987. The 10th International Workshop included a representation from 64 countries, with the largest representation from the USA, Australia, UK, Italy, and France . Professor Joshua credited the development of the intense and comprehensive scientific program to Dr. Joy Ho. The workshop's plenary and focus sessions were formatted as 15-minute presentations from renowned experts in the field, followed by questions and discussions from the participants.
Dr. Ian MacLennan opened the session on unconventional switched bone marrow plasma cells With Ig V-region mutations and provided a summary on multiple myeloma (MM), where tumor cells are found in the bone marrow. These tumor plasma cells produce antibodies via what may be classified as traditional or non-traditional (alternative) pathways. The presence of alternative antibody production pathways is supported by responses seen following rituximab treatment of patients with various autoimmune diseases. In these patients, rituximab sensitive and rituximab non-sensitive plasma cells are seen. Then the question arises as to which of these cells (rituximab sensitive or rituximab insensitive) may be involved in the origin of MM. Dr. MacLennan reviewed studies addressing traditional and alternative pathways for antibody production. Some studies show that cells producing antibodies (B-cell memory clones) respond to various triggers and that these cells can undergo mutations. Other studies show that there are alternate sources of tumor plasma cells and suggest that both traditional and non-traditional pathways for producing antibodies exist.
Dr. Selina Chen-Kiang followed with a discussion on cell cycle control in MM. Dr. Chen-Kiang identified MM as a disease of cell cycle dysregulation and loss of apoptotic control. Positive cell cycle regulators [cyclins and cyclin-dependent kinases (CDK)] and negative cell cycle regulators (CDK inhibitors) control cell cycle progression and myeloma pathogenesis. Chen-Kiang and colleagues proposed that an imbalance in positive and negative cell cycle regulators occurs as an early event in MM pathogenesis. They developed functional cell assays to examine cell cycle regulation and identified specific cyclins, CDKs, and CDKIs that are associated with tumor stages. Specifically, cyclin D is correlated with a more favorable clinical course of MM. The use of the functional cell assay along with other prognostic indicators may improve the ability to characterize the likelihood of disease progression and the aggressiveness of the disease. Use of the assay may also assist with the development of therapies targeted at cell cycle regulation.
Dr. Federico Caligaris-Cappio reviewed the role of hypoxia in the bone marrow microenvironment in his discussion of cross-talk between plasma cells and the microenvironment. Plasma cells from patients with MM express statistically significantly more hypoxic factor 1-alpha (HF1a) than do plasma cells from MGUS patients. Hypoxia also turns on an angiogenic switch; plasma cells in MM are hypoxic and so are producing angiogenic factors. Notably, hypoxia causes a large number of cells to proliferate. Strong interactions between MM cells and the bone marrow icroenvironment results in signals being delivered to developing tumor cells. These interactions may serve as a new target for developing therapies. Similarly, the potential for T cells to act in the bone marrow microenvironment of MM may lead to the potential to develop an immunotherapeutic therapy based on T-cells recognizing naïve tumor cells.
Dr. Jesus San Miguel reviewed the use of immunophenotypingusually restricted to research or to the diagnosis of unusual cases of MM and the potential this technique has in daily practice. Immunophenotyping identifies the abnormalities in plasma cells and thus distinguishes between normal and malignant plasma cells. Identification of such differences in antigen profiles provides a means to distinguish between monoclonal gammopathy of undetermined significance (MGUS) and MM; MGUS patients routinely have greater than 5% normal plasma cells while MM patients routinely have less than 5% normal plasma cells. When assessing minimal residual disease (MRD), immunophenotyping applies to the vast majority of patients and is highly predictive or the risk of relapse. Dr. San Miguel discussed the results of more than 700 of his patients who were treated using the GEM2000 protocol. Antigen panels were obtained before chemotherapy was initiated; more than 90% of cases of malignant plasma cells had abnormalities in antigen expression. All MM patients were positive for CD38 and CD138 antigens; B-cell antigens were present in 5% to 20% of cases. They observed a down regulation of CD56 and CD117 correlated with a poor prognosis and shorter survival. Similarly, CD19 and CD28 were correlated with poor prognosis while CD20 and CD 35 had no influence on prognosis. These results support the clinical benefits of immunophenotyping MM patients.
Dr. Michael Kuehl opened session 2 with his discussion on th integration of genetics in a comprehensive pathogenesis model for MM. He stated that MGUS and MM may be considered as a cluster of different diseases that have distinct characteristics through progression of the diseases. MM can be organized into 7 groups based on expression of at least 1 cyclin D gene. The 7 groups are quite distinct with variable degrees of bone disease, frequency of relapse, and progression of tumors. Kuehl and colleagues suggest that dysregulation of the cyclin D gene may be an early or initiating event in the development of MGUS and MM. The investigators suggest that characterizing tumor cells may assist with the selection of therapies most likely to be effective against a specific tumor cell for patients.
Dr. Leif Bergsagel and colleagues suggested that early pathogenic events determine MM biology and clinical course. Specific IgH gene translocations, while infrequent at diagnosis, increase in frequency with relapse and correlate with poor prognosis. By analyzing 6 specific genes, clinical features of individual's disease, prognosis, and response to therapy can be identified. Patients with a 4p16 immunoglobulin translocation have a poor survival regardless of the treatment regimen they receive and so new treatment options need to be developed. Bergsagel and associates are evaluating novel agents that would specifically influence pathways affected 4p16 translocation.
Dr. Rafael Fonseca provided an overview of the integration of genetics in a comprehensive pathogenesis model for MM. Different pathways of pathogenesis follow from MGUS to MM and the progression from MGUS to MM likely follow specific pathways dependent on the genetic composition of the MGUS cells. In rapidly progressing cases, long term bone destruction does not have time to develop. The susceptibility for individuals to develop MGUS and MM is not clear but may be related in part to racial differences linked to the ability to repair double stranded DNA. Fonseca and colleagues suggest that genetics must be incorporated into the development of targeted therapies. Such an approach would identify the treatment regimen most likely to succeed for individual patients.
Dr. Johannes Drach reviewed the epigenetic changes in the molecular pathology of MM. Methylation of specific regions of genes blocks tumor suppression genes in some cancers. By comparing the methylation profile of MGUS and MM genes, Drach and colleagues were able to identify genes that were associated with MM. They report that the development of MM is stimulated by multiple genetic abnormalities and that methylation may be a signal of an early event or of disease progression.
Dr. Linda Pilarski presented findings on alternative gene splicing in myeloma hyaloronan synthetase 1 (HAS1) synthesizes hyaluronan (HA), an extracellular matrix protein that is involved in cell signaling and in malignant progression. HAS1 is the first blood born prognostic marker for malignant cells and predicts poor outcomes in MM patients. Various forms of HAS1 may be produced in cells and these various forms have strong impact on clinical outcomes. Pilarski and associates report that abnormal forms of HAS1 may predispose patients to disease or to the development of progressive MM and short survival.
This focus session presented exciting new findings on standard and supportive therapies in MM. Dr. Donna Weber posed the question, "Is Thalidomide First-line Therapy?". She presented an overview of several trials utilizing combination therapy of thalidomide in untreated MM. The results of these trials, at this time, showed a clear superiority for using thalidomide, but also the increased risk of thrombosis and neuropathy. Several more trials have ensued using combination thalidomide, but with the use of prophylactic anticoagulants. Dr. Weber indicated that further research will evaluate the use of newer agents and lower doses of thalidomide to provide a greater response with fewer effects.
Dr. Maurizio Zangari followed Dr. Weber and provided an overview of the early uses of thalidomide and its teratogenic effects. Dr. Zangari pointed out that the success of thalidomide with leprosy led to the initiation of clinical trials in oncology. Research in these areas demonstrated a possible association of thalidomide with thromboembolism. Because incidence was low, several trials with thalidomide in combination with existing agents have been investigated for the newly-diagnosed patient with MM. Incidence of thrombosis with thalidomide has been observed to occur in early treatment with thalidomide and there is a higher incidence with newly diagnosed patients compared with relapsing patients. Dr. Zangari reviewed studies that compared prophylactic low- weight-molecular heparin, warfarin, and aspirin with thalidomide-based therapies suggesting that there may be a reduction of thrombosis with prophylactic therapy. Another complication seen in trials with thalidomide is the observation of sinus bradycardia. Similar to the management of thromboembolism, prophylactic use of anticoagulants is recommended for cardiovascular complications.
Dr. James Berenson presented new advances in the management of myeloma bone disease. A clinical consequence of MM is bone disease in non-vertebral bones and vertebral bodies, ultimately leading to spinal compression and impacting the patient's quality of life and survival. A review of a 21-month period showed that more than half of patients with MM develop bone fracture requiring radiotherapy. Vertebral compression is the most common complication leading to bone pain. Kyphoplasty, a minimally invasive and simple procedure, expands the collapsed vertebral body thereby reducing pain and improving patient function. An important therapy in managing patients with MM includes the use of bisphosphonates. Most of the trials of the last decade have shown a marked reduction of bone fractures with the use of IV bisphosphonate (pamidronate). More recently, the introduction of zoledronic acid, a more potent treatment, has shown to be effective in managing patients with MM and breast cancer. Dr. Berenson reviewed a trial comparing this newer agent to the pamidronate. The results from this trial showed that zoledronic acid was as effective as pamidronate; however, the infusion rate of zoledronic acid was modified to reduce the risk of renal impairment. Dr. Berenson advised the supplemental use of oral vitamin D and calcium with the administration of bisphosphonates to optimize the patient's bone health. A possible risk of bisphosphonate use is osteonecrosis of the jaw. Several treatment options for osteonecrosis include good oral hygiene as prophylaxis and throughout the duration of treatment, as well as intermittent antibiotic use. He cautioned against surgical intervention. Dr. Berenson closed by comparing the benefit to risk ratio of bisphosphonate use. Benefits include reduced bone fractures, less radiotherapy, and decreased bone pain.
Dr. Graham Jackson discussed the common complication of renal impairment in patients with MM; 20-30% of patients suffer from renal impairment at diagnosis, 50% at some time during the course of their disease, while 2% require dialysis. Dr. Jackson reviewed major factors contributing to renal impairment such as dehydration and hypercalcemia with the major cause of renal impairment due to tubular damage. There has been conflicting evidence in the literature about the use of plasma exchange to improve renal function. Dr. Jackson presented a new study taking place in the UK (the MERIT study), which is currently enrolling patients to determine whether plasmapheresis affects overall survival and quality of life. Dr. Jackson encouraged collaborators from different countries to participate in this trial.
Dr. Heinz Ludwig closed the session with a discussion on the prevalence, pathogenesis, and treatment of anemia with erythropoietic agents. Anemia is a common complication with MM and has a higher prevalence in MM than in patients with solid tumors. He stated the main goal of the European Cancer Anemia Survey (EACS) is to analyze the prevalence of anemia, the incidence of anemia, the impact of age, identify predictors of anemia, and treatment options. Dr. Ludwig indicated that age is an important factor to consider with anemia and in a recent study with elderly patients, whose median age was 68 years, the prevalence of anemia was 72%. Dr. Ludwig recommended that treatment options should be based on the patient's individual symptoms and less on hemoglobin levels and symptomatology. Erythropoietic agents, transfusion, and iron supplements may be considered as treatment options. The benefits of erythropoietic treatment agents include an increased appetite, improved cognitive function, and improved quality of life, while reducing dependency on transfusions.
The third plenary session opened with Dr. Dalsu Baris, of the NCI, discussing the epidemiology of MM. The highest risk of MM in the United States is among Blacks, with the lowest risk, in both Asia and the United States, among Asians. Mortality is higher in Blacks versus Whites, and higher in males versus females. Dr. Baris presented SEER data showing an increased risk MM with increased age. Risk factors are unclear but are related to exposure to ionizing radiation, solvents, and agricultural and farming occupations. Studies also suggest an association of MM with low socioeconomic status (SES) and obesity. A recent study conducted among women in Connecticut ( United States ) examined the impact of environmental, lifestyle, and genetic factors with the risk of MM. This study showed the risk was higher for subjects with less than a high school education and those in the lowest economic bracket. There was no evidence of increased risk with smoking or use of alcohol; however, this study did find that risk was increased with an increased body mass index (BMI). Although it appears that environmental factors may have a part in the pathogenesis of MM, further, larger studies will need to be conducted to identify exact environmental agents and genetic factors.
Dr. Robert Kyle followed, presenting an update on smoldering MM (SMM). Dr. Kyle characterized SMM with a serum M-protein level of 3 g/dL or higher, or 10% or more plasma cells in the bone marrow. He stated that the definition of SMM is not standardized and it is not known whether both M-protein and bone marrow plasma cells are necessary for diagnosis. Dr. Kyle provided an update from his study at the Mayo Clinic ( Rochester, Minnesota, United States ). In this study, patients were categorized in three groups of SMM; patients had a median age of 65 years. At the 15-year follow up, 53% of patients had progressed to MM, 2% of the patients had progressed to primary amylodosis ( AL ). Dr. Kyle concluded that most patients with SMM have a much greater risk of progressing to symptomatic MM or AL .
Dr. Joan Blade supported Dr. Kyle's presentation with his discussion on the evolving versus non-evolving nature of asymptomatic monoclonal gammopathies. Monoclonal gammopathy of undetermined significance (MGUS) indicates a serum M-protein of less than 30 g/dL and less than 10% bone marrow plasma cells (BMPC). Dr. Blade commented that evolving SMM showed a progressive increase in M-protein size until symptomatic MM developed. Whereas, non-evolving SMM characterized a stable M-protein until symptomatic disease developed. In studies, the median time to progression to symptomatic MM was 3 years. However, the evolving SMM had a shorter median time to progression of 1.5 years. Studies also showed that evolving SMM has a pattern of genetic abnormalities and chromosomal losses, whereas chromosomal losses were less common in non-evolving SMM. Dr. Blade's preliminary analysis suggests that MGUS is a predictor of malignant transformation probability.
Dr. Philip Greipp provided an update on the International Staging System (ISS) for MM and indicated that an article on ISS is to be published in the May 20 issue of the Journal of Clinical Onoclogy. The staging system was developed after analyzing the data from 3 groups: Asia, Europe, and North America . The goal was to develop a validated and confirmed staging system for MM. Results from the study formed 3 stages based on ß2 microglobulin and albumin levels. A summary of survival outcomes based on these stages was presented: Stage 1 = 62 months, Stage 2 = 44 months, Stage 3 = 29 months. The ISS staging system may prove to be superior to the Durie Salmon staging system with more equal distribution across the 3 stages. Dr. Greipp suggested that the ISS system should be the only system used until another easily usable, validated, and confirmed system is developed.
Dr. Brian Durie next presented advances in diagnosis and imaging in MM. He focused on the importance of a precise diagnosis especially with the new understanding of disease biology made available from imaging. Dr. Durie discussed the critical role of new molecular pattern classifications such as circulating nucleotides RNA and DNA. In 2005, approximately 25% of patients are diagnosed with MM during their routine physical exam. In addition to standard methods, new techniques should be added to the patient work up, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) scans. The use of these imaging agents provides a full spectrum view of the disease through a full body scan including extramedullary area. The prognostic and predictive value of circulating nucleic acids (RNA and DNA) provides a new understanding of MM and allow for better tracking and monitoring of the disease.
Dr. Surinder S Sahota reviewed normal plasma cell development and pathology of MGUS and MM. In order to understand MM, one must understand the origin of the plasma cells causing MM. Sahota and colleagues focused on analyzing the regions of immunoglobulin molecules present in MM and MGUS to answer some of these questions. Their research showed that normal plasma cells produce different forms of immunoglobulins G and A in response to signals from the bone marrow. In smoldering MM plasma cells, some immunoglobulins are produced consistently. In MGUS, these same immunoglobulins are produced in a variable manner and Sahota suggests that these variable immunoglobulins are linked to the development of MM.
Dr. Regis Bataille and colleagues suggest that an understanding of the different classes of plasma cells identified by the protein CD45 may lead to a better understanding of the development and progression of MM. Abnormally growing plasma cells are maintained by a very small fraction of plasma cells and these cells have a specific CD45 molecule on their surface. Identifying which CD45 molecule is on the surface of the plasma cells may help to distinguish different types of MM. For example, some CD45 molecules are associated with more proliferation of plasma cells, some are increased when MM progresses, and some are associated with poor prognosis. An understanding the correlations between the types of CD45 present on plasma cells and MM may assist with the development of therapies.
Dr. Bernard Klein presented on the identification of intracellular communication involved in MM with microarrays. MM cells must interact with the bone marrow to continue to grow and proliferate. Growth factors in the bone marrow influence the ability of plasma cells to grow and thus influence the progression of MM. Klein and associates suggest that identifying molecules that may inhibit these growth factors may impact myeloma cell growth. By identifying patients with specific genes, Klein and associates suggest that specific therapies may be able to be developed to meet the needs of those individual patients.
Dr. Michio Kawano discussed the function and movement of CD45 molecule in interleukin-6-induced myeloma cell proliferation. Myeloma cells vary in morphology and genetic composition. Normal myeloma cells have a variety of CD45 molecules on their surfaces. The stage of development of the plasma cell (immature, mature) and the presence or absence of CD45 on the cell surface determines whether the cell can respond to stimulants, such as interleukin-6 (IL-6). IL-6 is a growth promoting factor which causes CD45+ immature myeloma cells to proliferate in the bone marrow. The amount of IL-6 is limited so that CD45+ cells are converted to CD45- cells which are then more stable to environmental stress. Kawano and colleagues suggest that therapeutic strategies should focus on CD45.
Dr. Thomas Rasmussen presented on MM14q32 translocations. Researchers have not yet identified which cells are involved in the genetic events necessary for the development of MM. Rasmussen and colleagues looked at memory B cells to find out whether those cells contain the same genetic memory that is seen in MM plasma cells. Although B cells have some of the characteristics on MM plasma cells, B cells do not have the key characteristics of plasma cells that develop into malignant MM plasma clone cells.
Dr. Michel Attal opened the fourth plenary session with an update on the Intergroup Francophone Du Myelome (IFM) study on maintenance treatment with thalidomide and pamidronate after autologous transplantation. Dr. Attal reviewed the IFM's previous findings that high-dose therapy (HDT) significantly increased survival over use of conventional chemotherapy. More recently, studies have shown that double transplant significantly improves overall survival versus single transplant. This outcome has been seen in patients who do not achieve a very good partial response (VGPR) after first transplant. Today MM is the first indication for transplantation. The IFM designed a trial to evaluate the impact of maintenance treatment with thalidomide and pamidronate after HDT. Patients were treated with 3-4 cycles of vincristine, adriamycin, and dexamethasone (VAD), followed by a first autologous transplant with melphalan 140 mg/m2 and a second transplant of melphalan 200 mg/m2. Patients were then randomized to receive no maintenance, maintenance with pamidronate, or maintenance with pamidronate and thalidomide. Based on interim analysis, thalidomide was found to significantly decrease incidence of progression, improve progression-free survival (PFS), and significantly improve 3-year PFS. This benefit was mainly observed in patients with 1 adverse prognostic factor. Pamidronate was found to significantly decrease the 3-year risk of bone events. Dr. Attal indicated that a longer follow up is required to further assess patient outcomes.
Dr. Bo Bjorkstrand's presentation focused on the value of transplant registries. He provided an overview of the European Group for Blood and Marrow Transplantation (EBMT) and the history of data collected on allogeneic and autologous transplants since 1983. Recent studies are being conducted to determine the impact of donor gender and transplant, stem cell transplant (SCT) in plasma cell (PC) leukemia, SCT in rare MM type, and SCT in amyloidosis. From 1986 to 2005, a total of 19,562 patients have been registered. The data from this registry show that the majority of patients are male and younger than 60 years of age. Time from diagnosis to first transplant is less than 1 year. Overall survival (OS) at 10 years post-transplant is 40%; with PFS at 20% and complete response (CR) at 50%. An analysis of prognostic factors showed a slight significance of survival with females, and patients less than 60 years of age performed better with transplant. Dr. Bjorkstrand summarized retrospective study results of autologous SCT in PC leukemia and autologous SCT in rare MM. He lastly highlighted the registry's key benefit: continuous monitoring of transplant activity shows information on trends and changes in treatment methodology.
In the next presentation, Dr. Mario Boccadoro reviewed findings from the Italian study, which, by using intermediate-dose melphalan, showed superior to standard treatment in elderly patients with myeloma. Specifically, intermediate-dose melphalan (100 mg/m2) followed by ASCT constitutes a more effective first-line regimen than standard treatment of melphalan/prednisone in those aged >65 years, improving response rate, EFS, and overall survival (OS). Currently, a study is being conducted to evaluate intermediate-dose melphalan (100 mg/m2) with high-dose melphalan (200 mg/m2); results from this study are pending.
Dr. Bart Barlogie's presentation was an update on total therapy 2 (TT 2) versus total therapy 1 (TT 1). Dr. Barlogie reviewed data supporting the superiority of TT 2 over TT 1 with improved CR duration and doubled EFS. TT 3, a successor protocol including bortezomib with DT PACE, shortens the induction phase to 2 cycles to allow for completion of tandem transplants. Dr. Barlogie cautioned that the study is ongoing and that results will be discussed at future meetings in 2005.
Dr. Jean-Luc Harousseau's presentation was a focus on the benefits of double autologous stem cell transplantation (ASCT) versus single. He reviewed results from several studies that are showing a trend towards significant benefits in EFS and OS with double ASCT. He commented that longer follow up is needed before drawing conclusions; however, preliminary results are in favor of double ASCT. He stated that patients with adverse prognostic factors have a poorer outcome and the only factor that can predict the impact of a second transplant is the result of the first transplant. Preliminary results using fluorescent in-situ hybridization (FISH) analysis in the IFM 99 trial show that double ASCT improves results and poorer results could be related to cytogenetic abnormalities. Dr. Harrousseau discussed potential future trials with the use of novel agents instead of double ASCT, or in combination with double ASCT (before transplant to increase overall CR/VGPR or to decrease number of patients who will need a second transplant; or after transplant), or the use of novel agents as part of induction treatment regimen.
Dr. G. David Roodman presented on the pathogenesis of bone disease in MM. Bone lesions occur in up to 80% of MM patients; bone fractures occur in 60% of MM patients. MM patients also experience bone pain related to destruction of their bone tissue. Roodman and associates show that myeloma cells are involved in both the destruction of bone tissue and in the prevention of the repair of bone tissue. Patients with MM produce molecules that stimulate osteoclasts (cells that break down bone tissue) and inhibit osteoblasts (cells that build bone tissue). Combined, these effects result in the severe bone disease that MM patients experience.
Dr. Greg Mundy discussed osteoblast function in MM. Myeloma cells are found in bone marrow and through the course of MM myeloma cells influence bone destruction by inhibiting formation of bone and increasing resorption of bone. Velcade is successful in the treatment of myeloma, causing the myeloma cells to behave in a more normal manner. Mundy and associates suggest that Velcade may also be helpful in stimulating bone formation, thus possibly acting as a treatment for bone disease associated with myeloma. They are conducting experiments to clarify if Velcade can both limit tumor burden and repair bone destruction.
Dr. Peter Croucher outlined bisphosphonates and the bone marrow microenvironment. Managing bone disease is necessary for MM patients. To date, only bisphosphonates are used to treat bone disease in MM patients. Research in animal models of bone disease shows differences between the various bisphosphonate agents. Pamidronate and zoledronate improve survival in a myeloma model; ibandronate has no effect on survival in the same model. Croucher and colleagues suggest that treatment with bisphosphonates may have an anti-myeloma effect that may be mediated in part by inhibiting bone resorption.
For more information regarding these sessions, look for the complete proceedings to be published after the conclusion of this workshop.


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Blookie delights
Fiona McCann
Kudos to David Maybury , Sinéad Keogh and all at the Irish Blog Awards for a fascinating evening of all things blog to bookish and back again. The panel of bloggers, writers, publishers – generally, people that know a thing or two about books – engaged with a lively audience of all of the above (plus some infiltrating hacks), with plenty of debate over the merits of writing blogs whether as writing practice or to get noticed, as well as some interesting debate about the future of books in an electronic age. Speaking of which, has anyone switched their reading medium yet from old-school page turners to new-fangled e-bookery? Do such formats spell The End for our beloved books?


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Britain's Roz Savage is a heavy hitter in the male-dominated realm of global adventure.
She left an 11-year career as a management consultant and a marriage of the same duration in 2002 to become the first female rower to complete solo passages across the Atlantic, Pacific and Indian oceans.
During her most recent journey, which she will detail in a multimedia production in Mesa on Wednesday, Feb 8, Savage was alone on the Indian Ocean for five months, braving 20-foot waves and capsizing in her 23-foot rowboat.
She was named Adventurer of the Year in 2010 by National Geographic magazine and joined the ranks of United Nations Climate Heroes in 2009 for her environmental work.
We talked with Savage, who uses her travels and public appearances to spotlight environmental issues, about the challenges she has faced and her motivation to continue at age 44.
Question: What type of program do you have planned for Mesa?
Answer: I've got a cool, new presentation that I developed with the Google Earth people. We've got some fun animations that hopefully give an idea of the scope of these voyages. As the audience is taken on a swooping tour around the world, along the routes of my voyages, I hope that will bring things to life.
Q: Will you also be touching on some environmental issues?
A: I generally can't help myself. The whole reason I got into the ocean (voyages) was because I had an environmental epiphany and need a platform to get the message out there, to raise awareness, to say to people, "We need to wake up to what we're doing." But I'm cautious about not preaching; I try to weave it in subtly.
Q: Did you encounter some challenges on the Indian Ocean last year that you had not experienced before?
A: I was surprised how scary I found the Indian Ocean. It was very rough, and about a month before the end, I capsized a couple times. ... Once you get gun-shy about being capsized, every time you hear a big wave coming, you wonder if this one is going to take you over again. The other challenge was just how long it took me.... Five months is a long time to be on your own.
Q: Have you ever felt like you were being pushed to your limit or beyond on these voyages?
A: Yes, absolutely. I don't think it has ever gotten any easier out there. There's always some challenge, whether it's the duration or a technical challenge with equipment failing. A couple of times on the Indian Ocean, my whole electrical system was in danger of ceasing to function. It doesn't just mean that I don't have an iPod, it means I might not have a functioning GPS or water maker (for making saltwater potable).
Q: You posted a blog by adventurer Erin McKittrick on your website (rozsavage.com) in which she writes that you and she are "definitely in the minority" as women in the world of adventure. Do you have a theory about that?
A: I wish that I did. I would love to see a lot more women getting involved in adventure because I think we are quite good at it. We tend to go slow and steady, and we have a very strong sense of self-preservation. ... If there are young women reading your article, I would say to them, "It's not a prerequisite to be 6 feet tall and have a bushy beard to go and have an adventure. We can all do it. You just have believe that you can do it."
Q: Has being out on the ocean solo for months at a time strained any relationships you might have?
A: At the moment, I (exist) as a homeless nomad, just traveling and rowing the world, always going where the next challenge takes me. I don't have a relationship at the moment, but I have good male friends.... I had that stage in my life when I was into the more conventional things.... But I reached a transition point, and I suppose I get my kicks out of adventure and out of having a sense of purpose.
Q: How do you view the United States' efforts regarding environmental concerns?
A: When I come back to Europe, I am so impressed with what is going on with the recycling, the plastic-bag bans, the subsidies available to people who install solar panels. There's lots of good stuff going on in America as well, but I would love to see America step up and take a more forceful role of leadership.
Q: How do respond to people who say they yearn for adventure but are too tied down by finances and other responsibilities?
A: We choose our own story. I absolutely relate to what they are saying because, for so many years, I was there.... I just reached a point where I made a big choice and I decided to let go of all those things that were stopping me.
It's like stepping through a mirror. It's difficult before you do it. But once you've stepped through the mirror into that magical world on the other side, you look back and you go, "Oh, that wasn't very difficult. And if I've done that, what else can I do?"
Roz Savage passing Diamond Head just before arriving in Honolulu Hawaii after rowing across the Pacific Ocean from San Francisco.
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Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2011 by Universitaire Ziekenhuizen Leuven.
Recruitment status was Active, not recruiting
Recruitment status was Active, not recruiting
Universitaire Ziekenhuizen Leuven
Information provided by:
Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
First received: April 26, 2011
Last updated: April 29, 2011
Last verified: April 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is ongoing, but not recruiting participants.
|Estimated Study Completion Date:
|No date given
|Estimated Primary Completion Date:
|No date given


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France says au revoir to non-biodegradable plasticware
September 15, 2016, 12:03 p.m. by Robin Shreeves
By 2020, plastic plates and utensils must be made to break down in an industrial compost system.
Mysterious garbage tsunami repels Hong Kong beachgoers
July 7, 2016, 3:51 p.m. by Matt Hickman
While the exact source of the ghastly 'plastic tide' is unknown, officials believe it originated in mainland China.
Weird things that have been banned (and why)
May 20, 2016, 12:55 p.m. by Starre Vartan
Looking at what's disallowed in other places gives a peek inside other cultures — and our own.
Brewery's edible 6-pack rings protect marine animals
May 18, 2016, 3:11 p.m. by Robin Shreeves
Why didn't someone think of this before?
New York City passes 5-cent bag fee
May 6, 2016, 12:22 p.m. by Robin Shreeves
Want paper or plastic? Plan on sharing a nickel for the convenience.
In Virginia, a Stonehenge built from foam seeks a new home
May 3, 2016, 7:13 p.m. by Matt Hickman
The uncannily realistic replica is being displaced by a new state park.
10 creative ways to upcycle your plastic bottles
May 2, 2016, 3:45 p.m. by Kelly Ladd
These DIY projects will have you see plastic bottles in completely new ways.
Rotterdam is on a plastic bridge-building spree
March 31, 2016, 1:42 p.m. by Matt Hickman
While unconventional, plastic has advantages over concrete and steel.
How do you rescue a tangled porcupinefish? Very carefully.
March 25, 2016, 3:14 p.m. by Russell McLendon
Dodging sharp spines, a clever snorkeler uses a broken bottle to save a porcupinefish from a fishing net.
Bacteria that devours plastic discovered near Japanese recycling facility
March 11, 2016, 4:02 p.m. by Michael Graham Richard
300 million tons of plastics are made yearly, but we only recycle about 14%.
These psychedelic beach huts are made from plastic waste plucked from the ocean
February 26, 2016, 3:34 p.m. by Matt Hickman
Hunker down in a recycled plastic pineapple next to the sea.
This nifty backpack is made from a whole bunch of recycled plastic bags
January 15, 2016, 6:30 p.m. by Matt Hickman
Onward Bag is landfill-skirting design at its most ingenious.


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|Thread Tools
|This thread is privately moderated by Mr Kamikaze, who may elect to delete unwanted replies.
My 2nd Chevron wing and the best news is this one is made in Australia (www.offtheedge.com.au). Heavily into combat now and this one is fast and hits hard. You need to be patient after a hit and let it go nose down and get some speed for the recovery, but when you get the knack it's easy. It will fly all around Bees and my old Fatboy. Also good for DS'ing if you have a spot for it. Build it smooth and you will be surprised at it's speed.
Update: Rebuilt it with the New Stuff and Monokote and damn it's even faster now!!!


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BARREL RUN WINERY, 3272 Industry Road, Rootstown: Take II Band, 7 to 10 p.m. Saturday. 330-325-1075.
GREENE EAGLE WINERY, 2576 Davis Peck Road, Greene: Wasted Youth, 7 to 10 p.m. Saturday. 330-583-9463.
HIGHLAND NAUS CLUB, 2350 Highland S.W., Warren: Karaoke with Tori on Friday and After Midnight on Saturday. 330-392-5861.
HOLIDAY SPORTS BAR AND GRILL, 2124 Elm Road N.E., Warren: DJ Joe 10 p.m. to 2 a.m. Friday; and Jeff Welsh, 9:30 p.m. to 1:30 a.m. Saturday. 330-372-6479.
LITTLE WING CAFE, 2750 Mahoning Ave. N.W., Warren: Dennis Drummond Group, 9 p.m. to midnight Saturday. 330-399-5896.
THE LODGE AT GENEVA ON THE LAKE, 4888 N. Broadway, Geneva-on-the-Lake: Take II Band, 3 to 7 p.m. Sunday. 440-466-7100.
McMENAMY'S, 325 Youngstown Warren Road, Niles: Bike Night, 6 to 10 p.m. today; Rudy and the Professionals, 7 to 11 p.m. Friday; DJ Jeff Burke, 11 p.m. to 2 a.m. Friday; Retro DJ Carl Severino, 7 to 10 p.m. Saturday; and Haymaker, 10 p.m. to 2 a.m. Saturday. 330-544-1732.
WARREN COMEDY CLUB AT THE SUNRISE INN, 510 E. Market St., Warren: Jeff Blanchard and Kathie Dice, 9 p.m. Saturday, $15. 330-506-0114.
BACKYARD BAR & GRILLE, 8942 Youngstown-Pittsburgh Road, Poland: Jam night on Tuesday.
BELMONT STAKES, 3136 Belmont Ave., Liberty: Karaoke on Saturday and Wednesday. 330-759-3939.
CLUB AMAURI, Monteen's Southern Cuisine, 3807 Belmont Ave., Liberty: Live entertainment on Friday and Saturday.
DONNA'S DINER, 10 W. State St., Sharon, Pa.: Live music on Friday. 724-346-7373.
GLOBE RESTAURANT, 6565 Truck World Blvd., Hubbard: Live music on Saturday. 330-534-9725.
JW'S OTHER CLUB, Park Inn at The Radison, 3377 New Castle Road, West Middlesex, Pa.: DJ today and Friday and live music on Saturday. 724-981-2879.
KUZMAN'S, 1025 S. State St., Girard: Live music on Friday and Saturday, ballroom dance on Monday and DJ on Wednesday. 330-545-8521.
QUAKER STEAK & LUBE, Sharon, Pa.: Live music on Sunday.
SHOTZ BAR & GRILLE, 3713 Oakwood Ave., Austintown: Live music on Friday and Saturday.
THE TAP HOUSE, 23 Chestnut St., Sharon, Pa.: Acoustic open stage on Friday. 724-342-9300.
TULLY'S, 101 Chestnut Ave., Sharon, Pa.: Live music on Monday. 724-981-3123.
VINTAGE ESTATE, 7317 South Ave., Boardman: Acoustic open stage tonight. 330-629-8080.


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Banana Republic Anna Karenina Lookbook & Coupons for Nov. 1 Shopping
|Pictured: Sheath Dresses from the BR collection
Banana Republic has now released the full lookbook for the upcoming Anna Karenina holiday collection. The collection is inspired by the new film version starring Kiera Knightley which is now set to launch on Nov. 16th in the United States. The lookbook from this collection, designed by the film's costume designer, Jacqueline Durran, looks a bit like Madmen meets Anna Karenina. There are many sheath dresses accented with lace and sequins. More befitting the styles worn by Tolstoy's Anna are the wool cape ($198 US), a faux fur tote($79.50 US) and the faux fur Russian hat ($59.50). One piece that seems to have nothing to do with the styles of Imperial Russian (either in title or look) is the Gatsby Fringe Clutch for $198.00. As far as I know the 1920s Gatsby style had nothing to do with Anna's Imperial Russia style, but somehow Scott Fitzgerald's Gatsby got thrown into this mix.
|Pictured: Jewelry and looks from the new Banana Republic collection
For me, the most interesting and accessible pieces in the collection are the accessories like the Ice Queen Necklace (79.50) and the Glimmer Bracelet (39.50). I agree with designer Jacqueline Durran that " A splash of sparkle is the key to creating looks that dazzle." With a sparkling necklace, you can make just about any dress in your closet holiday ready. If you like this collection, here's a little savings tip. There will be savings of 35% off on Nov. 1st in-store and online at Banana Republic's After 5 Event. If you're not a card member, you can still save 25% on Nov. 1st if you shop the collection. If you visit in-store in select New York (Rockefeller Center) and California (The Grove & Santa Monica Promenade) stores, costumes from the film will be on display as of Oct. 30th.
|Pictured: Banana Republic card members are eligible for discounts on the collection.
From Nov. 2-11th, card members can save 30% off the collection in-store and online. Now, I'm not here to advocate getting the BR charge card. If you want the savings, and you sign up for the card, make sure to pay it off right away. If you don't pay your charges on time, the BR charge card carries a $25.00 penalty fee for each missed payment. Just a little tip from The Recessionista. You don't want to eat up all your savings by paying steep finance fees later. What do you think readers? Are you lusting for Banana's interpretation of Imperial Russia style? To see more looks from the collection, visit my Pinterest board.


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Malone University – Summer classes begin May 6
May 3, 2013 | Release # 6626
Malone University will kick off the first of four summer sessions on Monday, May 6. All courses are open to all undergraduate Malone University students as well as students attending other universities.
Registration takes place in the Office of the Registrar Mondays through Fridays between 9 a.m. and 4:30 p.m., or call 330-471-8128 during office hours.
Summer Term Dates
Full Summer: May 6-August 9 (Internships, Advanced Topics, etc.)Summer I: May 6 - June 7Summer II: June 11- July 13Summer III: July 16 - August 10
Malone University, a Christian university for the arts, sciences, and professions in the liberal arts tradition, affiliated with the Evangelical Friends Church, awards both undergraduate and graduate degrees in more than 100 academic programs. Malone has been recognized by the prestigious Templeton Foundation as a leader in character development, as one of Northeast Ohio's Top Workplaces by the Cleveland Plain Dealer, and is ranked among the top colleges and universities in the Midwest under the category Regional Universities according to U.S. News & World Report's America's Best Colleges 2015
Suzanne Thomas, APR
Director of University Relations
Malone University
2600 Cleveland Avenue N.W., Canton, OH, 44709
Phone: 330-471-8239
Cell: 330-324-2424
Categories: academics


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Groktimus Primal's - What's for dinner?
I've been reading the Vegetarian Myth and The Omnivore's Dilemma and it sure is depressing to think about the food we eat. I believe it's healthier to eat as an omnivore since that's what nature definitely intended. I don't think a reasonably argument could be made to the contrary.
When one stops and thinks about it obviously eating meat is a waste of energy because the grains that fed the cattle could feed many more people than the eventually slaughtered cow could. Unfortunately living off of grains is unhealthy and also quite unsustainable. After all, growing massive fields of GMO mono crops destroys the land and the ecosystem that was on and around it. The massive crops are also powered by fossil fuels and we know that will create problems down the road.
Life cannot continue without death and the only real answer long term would be to vastly cut our population and go back to our hunter gatherer ways or at least sustainable farming practices. The truth is we have way overshot what the planet can support long term so we are damned no matter what in the long run. Plants need animals and animals need plants. Nature can be beautiful but at times it is quite ugly and necessarily so.
I guess the best we can hope for is that a few humans will be left alive to start over after world war 3 or some other apocalypse. We are probably too far down the rabbit hole to turn around even if there was enough consensus. I guess I will just maintain the selfish hope that I will be long dead before the major shit hits the fan.
Maybe like the Lost in Space movie we can colonize another planet before this one withers and dies!


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WAILEA — Francine Nicole Jenkins and Jonathon Edward Walraven, both of Kihei, are engaged to be married May 19, 2009, at Keawakapu Beach.
The couple selected that date because the groom's maternal grandparents were married May 19, 1956, and will celebrate their 53rd anniversary at the couple's wedding.
The bride-to-be is the daughter of Angela Jenkins of Ventura, Calif., and is an artist and homemaker to the couple's son, Lionel.
The groom to be is the son of Jim and Sherry Poppe of Kihei. He is employed in the mental health field.


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The 25 Best Renditions of Zelda's Overworld Theme
Zelda's iconic theme has inspired countless cover artists. Is your favorite on our list?
1UP Celebrates The Legend of Zelda's 25th Anniversary
Table of Contents | Gameography | Coolest Videos | Embarrassing Moments | Things You Didn't Know | Top 25 Theme Song Covers | Merchandise You Didn't Know Existed | Useless Items | Commercials | Why LTTP is Still Best | Retronauts Podcast
Second maybe only to Mario's theme song, which game composer Koji Kondo also wrote, Zelda's overworld theme is perhaps one of gaming's most recognizable melodies even amongst anyone who's never held a controller. And just as it's been said that the true measure of a great song is how well it lends itself to reinterpretation across any number of genres, the sheer number of tributes to the song perpetually stuck in Link's head floating around the Internet proves this immeasurably. Since it's opening phrase is no doubt already bubbling up in your ears, we'll spare no time before showing you what we deem the top 25 renditions of this famous tune.
25: For the mightiest job, this guy has armed himself with the smallest of musical tools: the recorder. More than just an instrument to blare "Hot Cross Buns," this guy lets his formidable lungs loose on the woodwind to deliver a performance of Zelda's theme in its original key, something he notes "is not easy on the recorder." We'll take his word for it.
24: Ever wonder what the Zelda theme would sound like with lyrics? Well, now you aren't alone, and you also don't have to wonder anymore. Brentalfloss channels the spirit of a toned-down Jack Black to sing forcefully about the game's loosest plot points, while also working in an ad for the strategy guide and Trojan condoms. It's goofy as hell, sure, but Zelda's a game worthy of such a gleeful homage.
23: Pop that pacifier in your gaping maw and ignite those glow sticks: this version is best enjoyed while on club drugs. (Not that we're suggesting you use drugs.) The song's main melody props up a couple of other new musical phrases, though it gets leeway on that by working in so many Link-grunting sounds and a plinky little piano to hint at the Hyrulian's inner sadness.
1UP Celebrates The Legend of Zelda's 25th Anniversary
Table of Contents | Gameography | Coolest Videos | Embarrassing Moments | Things You Didn't Know | Top 25 Theme Song Covers | Merchandise You Didn't Know Existed | Useless Items | Commercials | Why LTTP is Still Best | Retronauts Podcast
See Also
Comments (23)
golf clapPosted: Feb 25, 2011 12:00AM PST by HoLyWooD444
watching all those made me happy in the pants
5-3 FederationPosted: Feb 22, 2011 12:00AM PST by darrenHollywood
How can you leave out the greatest Zelda rap of all time...
Where the Hell is Rabbit Joint?Posted: Feb 22, 2011 12:00AM PST by bambamthepyro
When this came out, EVERYONE thought is was System of a Down.
This is an amazing orchestaPosted: Feb 21, 2011 12:00AM PST by Oscartaker
This guys are from Peru, my country, and their shows are just amazing. It can rival Video Games Live whenever, wherever, Please, give em a shot
they should have included this guy:Posted: Feb 21, 2011 12:00AM PST by chinpokoman
boba fett on an accordion playing the theme song.... so awesome
NicePosted: Feb 21, 2011 12:00AM PST by sepewrath
feature, definitely one of the most iconic themes in general; but I would have preferred just a top 25 songs of the series.
I'm glad Zack Kim was on here.Posted: Feb 21, 2011 12:00AM PST by Gold_Ultima
Guy needs more credit for how awesome he is. Still could use some Duane and Brando though.
them sumPosted: Feb 21, 2011 12:00AM PST by smile_kill
good themes in the zelda series
Zelda theme cover in one take, including Tenori-On and pixel art!Posted: Feb 21, 2011 12:00AM PST by krapo
How about a cover made in one take by one guy alone? I used a looper to record different layers of the music, and also don't miss the end of the video for some pixel love!
The Tesla CoilPosted: Feb 20, 2011 12:00AM PST by UnsungHero007
That is amazing. Simply amazing.
Granted, it's a medley...Posted: Feb 20, 2011 12:00AM PST by SecretMoblin
But this French duo playing LoZ music on piano/violin is amazing: http://www.youtube.com/watch?v=hkWcUtga1lw
what aboutPosted: Feb 20, 2011 12:00AM PST by halo2master
LINK by a very early system of down?
It's by The Rabbit JointPosted: Feb 20, 2011 12:00AM PST by ThomNoland
and it's awesome. Though, there is an even more epic version entitled: "Zelda: The Music of My Groin"


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While most Android users are waiting on updaters that might patch some of the recently reported security holes, CyanogenMod is already getting a bug fix update out the door. CyanogenMod 10.1.1 is now hitting the stable channel for all supported devices.
The Master Key exploit will be presented by Jeff Forristal at Black Hat 2013 as "One Root To Own Them All." It's essentially a bug in signature verification which can be used to insert malicious code into an APK.Read More


text: The Facebook page Transformers Asia has posted a series of new photos showing Masterpiece Shattered Glass Optimus Prime. The recolor can be seen in various poses and using its accessories, including the combat deck and repair bay functions of the trailer. A few shots give a chance to see it alongside other iterations of the MP-10 body - and notably the Nemesis version pulling the trailer, suffering only from mismatched insignias. We've mirrored the photos, click through to see them now!


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10% Cashback on Home Improvement & Furnishing Store Purchases
|Email Print
I logged into my AT&T Universal card account today and saw a special offer of 10% statement credit (basically cashback, but it won't count against your yearly limit) on all purchases at a home improvement or home furnishing store by May 31st, 2006.
As a valued AT&T Universal cardmember, you can earn a 10% statement credit on home improvement & home furnishing store purchases* made with your AT&T Universal Card by 5/31/06.
It's a huge orange button to the right of your account information, you can't miss it.
AT&T Universal Platinum Card might have it too (it's a cashback AT&T branded card as well).{ 7 comments, please add your thoughts now! }


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Pups dumped by roadside all find homes
Published 12/11/2012 | 05:00
IT WAS puppy love for families who queued to give homes to 15 pups that had been left to perish in a cardboard box less than 24 hours earlier.
After an appeal went out from the dog shelter for people to adopt the five-week-old puppies, there was no shortage of people who wanted to give them a loving home.
Siobhan McCabe was one of those who travelled from Navan, Co Meath, to be at the shelter in Carrickmacross, Co Monaghan, when it opened.
Her four children and partner went with her to pick their "new addition to the family".
"She is our first family dog and has been unanimously named Mow. She is gorgeous.
"It is awful that people can be so cruel and knowing that the pups could face being put to sleep if they didn't get homes; we wouldn't have been able to sleep at night if we didn't at least try to help one," she added.
Others came from as far afield as Belfast, Sligo and Kildare to ensure the pups -- which appear to be a cross between a labrador and a collie -- got homes.
Ciara Plant (23) and boyfriend Brian Connaughton (23) left their Naas home at 7.30am "to get in early. We saw the appeal on Facebook and fell in love with them.
"We were seventh in the queue. We got a girl and have called her Harper after Victoria Beckham's daughter, Harper Seven," said Ciara.
Helen Hewett, who set up Carrick Dog Shelter 14 years ago, said: "We have never before had so many pups in one go given to us. They are about five weeks old, too young to be weaned and should have been kept with their mother for another three weeks."
A motorist spotted the abandoned box on the verge of a busy road near Carrickmacross on Saturday and brought it to the pound.
His quick thinking ensured none of the pups wandered out of the box and onto the road.
Now Helen's concern is for the litter's mother. "She will be full of milk for the pups and without medical attention she could get an infection. I would fear that a person who would dump puppies like this would not bother to bring her to a vet. They can leave her with us at the shelter and we will care for her."
Irish Independent


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About us...
The Friends of
Recent accomplishments...
In recent years the Friends of
Holland School has played a major role in providing resources
to ensure that
Goals for the coming year...
The Foundation has now turned its attention to the playground, an area where periodic replacements and improvements need to be made. The current playground up-grade will require $35 000.00 to complete of which half has already been secured.
As you can see, your membership in this innovative foundation is of enormous importance to the leaders and good citizens of tomorrow, our children. Please complete the enclosed membership form below and return it to the school. Donations of $35.00 or more constitute membership and entitle the donor to a tax deduction. This year donors of $100.00 or more will have the opportunity to have their name placed on the playground donor board to be displayed in the school?s main entry.
How can you become a member of the Foundation?
Simply complete this form and return to the school with your donation to the address indicated or donate on line by following the Donate
We look forward to working with you to help teach the children of today to become the responsible, caring adults of tomorrowtomorrow.


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Bergen Catholic at Don Bosco Prep - Non-public, Group 4 semifinals 11-30-12
Saturday, December 01, 2012 1:13 AM
Inappropriate photo? Alert us.
Welsey McCoy (81) of Don Bosco Prep is tackled by Blu Fox (18) of Bergen Catholic during Non-public, Group 4 semifinal.Bergen Catholic defeated Don Bosco 21-14. Ramsey, NJ 11/30/12 (Noah K. Murray /The Star Ledger) HSSPORTS


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About GSKForYou
GSKForYou is a Web site designed to help people who need help paying for their GlaxoSmithKline prescription medicines. When you answer a few basic questions on the site, GSKForYou will guide you to a patient assistance program that may help to save you money on your out-of-pocket costs for your medicine. Eligibility criteria apply. GSK's coupons and vouchers are subject to change or discontinuation without notice.
GSKForYou also contains helpful information about resources both within GSK and from other trusted sources that provide information on how to manage various aspects of your health.
There is no cost associated with using GSKForYou. And patients who qualify for one of our patient assistance programs will go on to receive their medicine at no cost. NOTE: Some medicines are only available at a retail pharmacy and are not distributed through mail order.
How Does GSKForYou Work?
Those with no prescription medicine coverage, and are eligible, can enroll in one of our patient assistance programs in 3 easy steps. There are also savings offers available for specific GSK medicines for those who are eligible. GSKForYou can help show you the way to out-of-pocket cost savings.
You are about to leave a GlaxoSmithKline website. By clicking this link, you will be taken to a website that is independent from GlaxoSmithKline. The site you are linking to is not controlled or endorsed by GlaxoSmithKline and GlaxoSmithKline is not responsible for the content provided on that site.


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About Power PLAY
Created by the Vancouver Canucks fitness and nutrition experts in conjunction with local educators, the Vancouver Canucks and Canucks for Kids Fund are proud to offer: Power PLAY – Fitness. Nutrition. Fun. to intermediate classrooms across the province.
Created for students in grades 4-7 throughout British Columbia, Power PLAY is a great way for teachers to help fulfill required learning outcomes by teaching students about health and fitness with fun, engaging topics and activities.
Students will learn healthy eating and active living strategies through a series of class discussions and related activities. With the goal of being an inspiration to young students around these important topics, this free curriculum also looks at how your favourite Vancouver Canucks players eat right and stay in shape.
What's Included:
- All registrants will receive exclusive access to the password protected Power PLAY curriculum available online.
If you are a Grade 4-7 teacher who is interested in registering for this program for the 2016.17 school year, please complete the registration form.


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Thanks for helping us sort this video!
Thanks for helping us associate the correct Pornstars to this video!
Help Us: Do these Pornstars appear in this video?
Pornstar Name:
nothing hotter than a girl on all fours giving her pussy a good rub
so watching this makes me want my pussy licked hmmm
Omg! Best movie I have ever seen. I am serous.
Ohh damn so hot...
Die Dame mal so richtig durchziehen - nicht der schlechteste Gedanke...
The sheets aren't wet...therefore, no orgasim.
thats more fake than a blowup doll from walmart
she's dryer than the sahara desert...lol
Thats a REAL milf
not great,not my type of girl...how much is she being paid for this.....
fake as they come , looks dryer than me nans cakes


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The single sculls were back on the water in the Dad Vail Regatta this year after quite an absence, and the most solitary event in rowing made a very impressive return.
The awarding of the Philadelphia Challenge Cup for international-level rowers for the first time since 1966 was a highlight, but no one was more excited to see the discipline back in the spotlight than the college rowers who competed for the Open Singles Sculling Collegiate Championship.
After two days of racing - in the heats on Friday and the finals on Saturday - it was no surprise that Oklahoma City University, which has been at the forefront of sculling's resurgence, swept both the men's and women's championship.


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The premier of Newfoundland and Labrador, Canada is defending his decision to come to the U.S. for heart surgery.
The Canadian press reports Danny Williams' decision raised eyebrows for shunning the Canadian health care system.
Still, Williams has defended his decision saying, "This is my heart, it's my health, it's my choice."
"I did not sign away my right to get the best possible health care for myself when I entered politics," he added.
Williams says he had the procedure at a hospital in Miami so he didn't have to "jump the line" waiting for the procedure in Canada.
"I have the utmost confidence in our health-care system, I certainly do," the 60-year-old told Canada's The Globe and Mail. "It's a bum rap for someone to turn around and say, 'Oh, Williams does not have confidence in his own health-care system because he has to leave the province.' "
Dems Hope to Revive Healthcare Bill
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Memphis avoids 0-3 run at Battle 4 Atlantis
PARADISE ISLAND, Bahamas -- There isn't much more pressure a team could face this early in the season.
No. 19 Memphis arrived in the Bahamas as one of four ranked teams playing in the eight-team Battle 4 Atlantis.
Losses to VCU and Minnesota by a combined 22 points left the Tigers in the seventh-place game on Saturday, against a Northern Iowa team that had taken No. 2 Louisville down to the wire in the opening round.
But the Tigers bounced back. Chris Crawford and Joe Jackson, two of Memphis' better players who had been struggling, scored 18 and 15 points, respectively, in a 52-47 victory.
"If we were 0-3, nobody would want to be around me," Memphis coach Josh Pastner said. "Rocks would have been thrown and maybe it would hit the players. We'd have to look out for snipers after we got off the plane. What's important is we won. We needed some momentum."
Memphis (3-2) was the only ranked team not to reach the semifinals, and things didn't look so great late in the first half against the Panthers, who led 26-12 with 4 minutes, 34 seconds to play.
"We just didn't get some rhythm (in the tournament overall)," Pastner said. "It's a long season. There are going to be some peaks and valleys. This is a good team we played. They'll beat a lot of teams going forward. It's not easy getting back-to-back losses come into a morning game then get down 14 in the first half and come out with a win. I'm really proud of my guys. That's why we play these tournaments. That win is going to help down the line in March."
- Minnesota 66, Stanford 63: At Paradise Island, Bahamas, Andre Hollins, a day after scoring 41 points, made three free throws with 0.4 seconds to play to give Minnesota a victory over Stanford in the fifth-place game of the Battle 4 Atlantis.
The game was tied at 63 and Minnesota was inbounding the ball from under its own basket. After an inbounds pass, the ball was tipped away by Stanford's Dwight Powell, who saved it as he was falling out of bounds near midcourt. Hollins calmly corralled the loose ball and dribbled to midcourt, where he launched a shot and was hit on the right arm by Stanford's Chasson Randle.
As Randle crouched in front of his bench holding his head as teammates patted him, the officials went to the monitor to see if the foul happened after time expired. They put 0.4 seconds back on the clock and Hollins made all three free throws.
A long pass by Stanford was knocked away by Minnesota and the buzzer sounded.
- Notre Dame 69, St. Francis 52: At South Bend, Ind., Jack Cooley had 13 points and 13 rebounds Saturday to lead Notre Dame to a win over St. Francis of Pennsylvania.
Eric Atkins and Cameron Biedscheid each scored 13 points as well for the Irish, and Garrick Sherman had 11 points in his first start of the season.
Umar Shannon scored 14 points and Ollie Jackson had 12 points on four 3-pointers for St. Francis (0-5), which lost its ninth straight road game dating to last season. The Irish (5-1) have won 39 of their past 40 home games and improved to 44-0 all-time in November under coach Mike Brey.
Cooley recorded double figures in points and rebounds in the same game for the 17th time in his career.
- St. Bonaventure 80, Niagara 75: At Rochester, N.Y., Chris Johnson tied his career high with 19 points and Demitrius Conger added 18 points and 10 rebounds to lead St. Bonaventure to a victory over Niagara.
Conger made two free throws with 31 seconds remaining to break a 75-75 tie, then was 3-of-4 from the line with 1 second left after a Michael Davenport steal and a technical foul on the Purple Eagles' bench.
-- from wire reports


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Top Definition
1.The type of girl who is lame enough to have zero friends, so she acts as a friend to random people until she finds the perfect girl who is finally lamer than her. 2. A user and abuser of "friends." Appears to have the perfect life, but she is really nothing special once her true colors show.
The girl who pretended to be my friend is really nothing but a caddy bitch.
by sickofem01 November 24, 2010
Trending Now
Can you define these popular missing words?


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Today a third-grade teacher in a Philadelphia School District classroom, next month a teacher-training specialist with direct access to Superintendent William R. Hite Jr.?
District officials hope so.
They are recruiting a small group of people at every level of the organization, from teachers on up, to be part of a unique "Transformation Corps" - 15 or so employees who will work to solve the school system's most critical problems.
The members of the corps will answer to folks at the top reaches of the district and work with high-level mentors - successful superintendents and experts from around the country.


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The Ellen DeGeneres Show (3 p.m., NBC10) - Taylor Swift performs.
One Tree Hill (8 p.m., CW57) - Brooke and Julian get a surprise visitor.
NCIS: Los Angeles (9 p.m., CBS3) - A classified Pentagon document is uploaded to a blog site.
Frontline (9 p.m., WHYY TV12) - A N.J. doctor seeks out tough cases in an effort to bring medical costs down.
Hellcats (9 p.m., CW57) - The Hellcats and the girls volleyball team compete in an intense game of flag football.


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QUOTE (wingslogo19 @ July 8, 2009 - 03:51PM) <{POST_SNAPBACK}>
Really great story about joe
Yep, great story.
Joe Sakic was really the one Av I couldn't dislike. Maybe because by the time I should have disliked him, I'd seen him play enough (on really s***ty Quebec teams) that I'd really respected his game. He was awesome, he was classy, and he really seemed like an all-around good guy. He had that god damned wrist shot and, like Stevie Y, he lead by example. He was the total package -- absolutely a guy you'd want on your team.
Thanks for the memories Joe.


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- Selling the Promise of Youth -- BusinessWeek's March 20th cover story provides a great summary for baby boomers heading into their second life -- and the message is, you better have money if you want the quality of that second life to be the same as the first. Money, and the willingness to take some risks on unproven anti-aging treatments being sold. If you've got money, there's lotions, potions and promises galore awaiting you. The problem is, most are not recognized by mainstream medicine, and are not necessarily approved by government regulators. As one of the new age salesmen puts it however -- they promise a better quality life, followed by a rapid decline in health leading to death -- rather than the slow aches and pains to the grave. Thus far, there is no fountain of youth -- and trying some unproven drugs just might hasten your trek to the afterworld. Me, I'm waiting for the day my brain can be digitized!
- Is the MBA Overrated? -- Does an MBA really give an advantage? It has become a requirement for those looking to climb the corporate ladder, but I'm not so sure about it myself. I don't have an MBA, although it is one of those things I hoping to accomplish eventually -- but I'm in no hurry. I've had the pleasure of meeting quite a few MBA grads, and not one has left a lasting, overwhelmingly positive impression. Their MBA didn't seem to make a difference. Especially in those that went straight from an undergrad to their MBA. As BusinessWeek points out in this article, their research is anything but conclusive when looking at the top ranks. Those who reach the pinnacle most often do not have MBAs. Goes to show you that there's only so much that book-learning can give -- the rest needs experience.
- A New Spark Plug for Cadillac -- Cadillac is looking to fix its brand image, so they've brought on board Liz Vanzura -- the ad executive that gave new life to VW and the Hummer.
- Making It Work By Not Doing It All -- BusinessWeek profiles Xerox R&D chief, Sophie Vandebroek, a woman who seems to have achieved the perfect balance in work and life. Read her story ... it's inspiring.
- It's Hard Out Here For a Lobbyist -- Governments don't respond to people, they respond to lobbyists. Check out this profile of the people who pull the strings and are the masters of spin.
- Here Comes Lunar Power -- Forget wind and solar power, both of which depend strongly on the weather. Check out instead, lunar power. Predictable, stable, and always there, the tides and turning turbines to create electricity.
- Spreading the Gospel -- BusinessWeek has an excellent article on the power players of outsourcing. There is an inner circle, and most are former employees of GE and McKinsey.
- Renovating Home Depot -- BusinessWeek's March 6th cover article profiles Home Depot's chief, Bob Nardelli -- a CEO who is going against the grain of management trends, and embracing a hardnosed military style. Out are small teams and collaboration, and in is a military organization. Hierarchical, with decision making coming from the top. It's an organization ruled by fear, with a focus on the details of operations. In the short term, Home Depot has achieved great financial results, but how long will they be able to keep up the pressure on staff? Especially with a strong competitor like Lowes, who's also building out.
Sunday, April 09, 2006
Posted by Andy Dabydeen at 4/09/2006 11:47:00 PM
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Maui Economic Opportunity Youth Services staff and peer leaders partnered with Hawaii Commercial & Sugar, Co. to paint a mural on a wall at the former Paia Sugar Mill.
The mural promotes alternatives to using drugs and alcohol.
The wall at the mill was selected because it was constantly vandalized and plagued by weeds, shrubs and trash.
Article Photos
A mural covers a wall at the former Paia Sugar Mill that was once plagued by weeds, shrubs and trash.
"Our hopes were that if we used the youth to paint a mural of positive activities and a positive message, then it would prevent future vandalism attempts and promote positive healthy activities while reminding the community about the history of Paia and of Maui," said MEO Program Specialist Cassi Yamashita. "When requesting permission to paint the wall, HC&S said they were excited by this opportunity and offered to pay for all the supplies needed, but they needed permission from the county. After speaking with Jan Shishido, deputy director of the county Department of Housing and Human Concerns, permission was granted and the project became a reality. The pictures of activities that were selected for the mural are cultural or island activities that most locals can relate to. Through this mural we hope to gain a stronger sense of local pride from the community."
MEO Youth Services is funded through the county Department of Housing and the state Department of Health Alcohol & Abuse Division.
For more information, call Youth Services Director Rose Duey at 249-2990.


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As I was telling ya a few days ago, the domain name you choose for your site is uber-important.
Pick a really good domain name and folks will remember you for it.
Pick a really bad one and folks will remember you for it too, but for all the wrong reasons .
These poor, unfortunate companies who in real life offer completely innocent products are being remembered for the latter reason. They picked a domain name that made sense to them, but they obviously didn't consider hard enough what the URL would look like to your average stopper-by.
Entrepreneurs, let us learn from their mistakes, shall we?
This list comes from Independent Sources:
1. A site called 'Who Represents' where you can find the name of the agent that represents a celebrity. Their domain name… wait for it… is
2. Experts Exchange, a knowledge base where programmers can exchange advice and views at
3. Looking for a pen? Look no further than Pen Island at
4. Need a therapist? Try Therapist Finder at
5. Then of course, there's the Italian Power Generator company…
6. And now, we have the Mole Station Native Nursery, based in New South Wales:
7. If you're looking for computer software, there's always
8. Welcome to the First Cumming Methodist Church. Their website is
9. Then, of course, there's these brainless art designers, and their whacky website:
10. Want to holiday in Lake Tahoe? Try their brochure website at
I must say that my faves are "speedofart" and "powergenitalia". It took me a while to get the Therapist Finder one as well as the Mole Station Nursery (I get it now! ).
I have to admit that I still don't get the "cummingfirst" one. Someone please explain that to me.
Questions for ya:
Which ones are your faves?
And do you have any to add to the list?
Painfully funny photo via (Rest easy, y'all. The puppy was not hurt.)


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Top Definition
A police officer who is considered a "bad ass" - usually due to strong street connection & credibility. May be corrupt or simply very influential in the community he serves.
Ref from the movie by the name Street Kings (starring Keanu Reeves) about influential, corrupt (some) LAPD officers.
додав alwayzknowin' 10 Липня 2009
Trending Now
Can you define these popular missing words?
One who stockpiles dirt on anyone that stands to get in their way, thus controlling them like a king controlling his peasants.
I have audio of my brothers and sister talking about doing drugs. I am the street king of my family.
додав Turtle Painted Blue 17 Лютого 2011
a group of serous gang mimbers that loves to fight, smoke, & they sell drougs but they al so shoot up blocks
them streetKing niggas are reall
додав chris powll 28 Лютого 2005
Notorious Gangster in Babbacombe, Other Urban areas may have similar names
Kris Hughes is a Street King (The Original King)
Other localisations include
Paington Street King (ReAd HeAd) or Brixham Street King (Frosty)
Other localisations include
Paington Street King (ReAd HeAd) or Brixham Street King (Frosty)
додав William Shakespear 21 Червня 2003


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Over the past few months in this monitoring series we have been looking at specific situations where B2B companies would benefit from using a social media monitoring solution, rather than relying on just Google alerts, Twitter search and other basic monitoring tools. One of the main reasons B2B companies need to consider using a more robust solution is the sheer number of keywords that you need to follow in many situations. For this last post in the series we will be looking at monitoring an industry, and as you can imagine, there are definitely lots of terms to follow in this example.
Discover Your Industry
You need to begin any monitoring program with a discovery phase and a project as large as following an industry is no exception. Start with general industry terms to find relevant sources, blogs and people talking about your industry. Using the dashboard features of many monitoring programs you will need to take the time to dig into each one of these possible sources to determine if they are keepers or not. There are always going to be new sources of industry information that crop up, as well as one-off posts or articles, but you really need to establish a base of credible information. Make sure you review trade publications, association web sites, blogs, news sites, forums in your sources and include the sites you already know.
Bonus Content Idea: If you publish a weekly blog post with industry news, posts or other industry relevant information, this is a great ongoing source.
Discover Your Competitors
One specific area to focus on in your industry is your competitors. Add their websites to your monitoring, as well as search for their company name, product names, executive names in all of your searches. You might even want to keep up with locations of their major plants, if they are large enough to have a dominant presence in a community. While these are the competitors that you know, there may be companies moving into the space with a single product or service, or even a whole product line that suddenly competes with your business. Use keywords that are both general and specific around your industry to make sure you don't miss any of these threats to your business. An early warning of this type may make your social media monitoring efforts all worth it.
Bonus Content Idea: An industry leader can openly blog about competitors on their own site. This makes management very nervous. With the depth of information from your monitoring, you can write about objective comparisons with your own products or services. Fight the marketing spin and be honest.
Discover Thought Leaders
One of the best ways to keep up with your industry is to keep up with the thought leaders. This is a totally different approach to keeping up with the news, products and events. This gives you an ongoing, higher level perspective of what is going on and where things might be headed in your industry. Or maybe where they should be headed. As with most of these suggestions regarding your industry, it is very likely you will know where to start on this. These would be the strategic thinkers at other companies, columnists at trade publications, event speakers, prominent bloggers. Once you have identified these individuals, make sure you monitor them by name. As you see who they interact with, those may be influential people worth monitoring.
Bonus Content Idea: By monitoring these thought leaders by name, you will learn where they are speaking, and you can easily arrange for a short video interview when they are speaking nearby.
I hope this post, and the series, has given you ideas and some necessary background for exploring social media monitoring solutions for your B2B company. If there are other situations that have benefited from social media monitoring, please leave comments below.
The B2B Social Media Monitoring 101 Series is sponsored by Jive Software | Jive on Facebook


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By Jessica Manuel
SHEPHERDSTOWN - To cap a strong year by Shepherd athletics, the baseball team is making a run for a conference title and more if the players have their way.
Article Photos
Shepherd's Matt Wilson (28) comes home on a wild pitch before West Virginia State's Tyler Thompson can apply the tag during the third inning of a doubleheader in Shepherdstown. The Rams won both games 7-5, 14-4.
The Rams currently sit in first place in the Mountain East Conference after a 13-game win streak with an overall record of 22-7 and a conference record of 20-4. No. 2 Urbana has a record of 13-7, 12-4.
Shepherd's been solid in at the plate and on the mound to push the Rams to where they are today, having not lost since March 16 to Concord.
"We're playing well. We haven't put all three phases together yet," Shepherd coach Matt McCarty said. "We're getting there."
The Rams place in the top 5 in plenty of categories in the MEC, but hitting is where the team really explodes. Shepherd has five players in the top 15 in the conference in average.
Michael Lott ranks fourth with an average of .435, while Matt Wilson (.417) is fifth. Spencer Wolfe (.407) follows in sixth, and Kyle Porter (.356) ranks 11th. Jacob Carney (.350) rounds things out at 13th. Overall, the team is tied for first in batting average with Concord at .326 and is first in slugging at .447. Wolfe and Matt Wilson both have a .617 slugging percent to be tied at third in the conference.
"Wolfe, he's a guy we knew when we got him in the fall, he was going to hit in the middle of our order," McCarty said. "He sticks to his approach."
While Wolfe's been a go-to guy for the Rams and a hitter other teams have kept an eye on, the batters around him have made it tough on opponent's pitching.
"Teams can't really pitch around him at this point," McCarty said, happy with how well and how consistent his lineup been. "Everyone's got a part in it. Early on, the bottom half of our lineup was doing really well."
Not only is Shepherd getting the hits, but the Rams are getting them in clutch situations. Three of the top five players in runs batted in come from the Shepherd lineup. Ryan Messina (26) and Wolfe (25) rank second and third, respectively, while Wilson (19) is fifth.
That production at the plate has Shepherd outscoring opponents 171-99 this season. The Rams work well early, outscoring or tying its opponents overall in every regular inning until extra innings in the eighth.
The Rams have picked up their share of extra-base hits this season with leaders in doubles and home runs. Wolfe, Messina and Porter are all tied at second with eight doubles, just two behind first-place Matt Paculan from Urbana. Wolfe ranks fourth in homers with three, tied with West Virginia State's Anthony Payne. The Rams are tied with Concord for first with 11 team homers.
When Shepherd's not hitting, it's shown some patience at the plate, adding to the second-place on-base percentage of .421.
Porter is first in the conference with 15 walks, while as a team, Shepherd is also first with 84. The Rams have been hit by pitches 84 times to lead the MEC as well.
McCarty said patience at the plate and taking those opportunities at free pass were some things the coaches have emphasized. He added that the team has more walks and hit by pitches than strikeouts.
"Which is almost unheard of," McCarty said, calling his lineup very mature. "I think a lot of it is sticking to their approach, not trying to be something they're not. They're not too anxious at the plate."
The Rams have also shown some speed on the base path with a conference-high 78 stolen bases. Porter leads the team and conference with 17, and Lott is tied for second with two other players with 13 stolen bases.
"It's big. That was one of the things we tried to implement last year. Just putting pressure on the defense," McCarty said.
Defensively, the Rams have used strong pitching to complement the hitting, not giving up the free passes the offense is taking from other teams.
"We're successful right now because we're not giving up free passes," McCarty said. "I like where we're at pitching."
Paul Hvozdovic has taken command of the starting rotation, leading the league with six wins as part of his perfect record. He's thrown four complete games and two shutouts and is 12th in the country in strikeout/walk ratio (9.25). Notching an ERA of 2.03, Hvozdovic ranks seventh in the conference and fifth in opponent's batting average (.221).
"Paul is a guy who's won 20 games the last two years," McCarty said. "He's matured. He's got a plan. He doesn't give away free bases and pounds the zone.
"He's one of those guys who knows what they're doing."
Hvozdovic has also struck out 37 to rank second in the conference, part of Shepherd's second-ranked overall strikeouts (133) and strikeouts looking (45).
Jamie Driver's been help to Hvozdovic, striking out a fifth-place 27 batter. Driver stepped up for the pitching staff when the team's No. 2 starter was injured earlier this season.
"Jamie was one of those guys who picked up the slack," McCarty said, adding he's done a nice job of getting ahead of hitters and keeping his walks low.
Tough relief pitching from Ryan Pansch, Bryan DiRosario and Tyler Thomas has helped keep the staff strong. Mac West is slowly being added to the bullpen, returning from a small injury.
"He's a guy that's going to help us out big," McCarty said.
Shepherd catchers pick off runners as well as any in the conference as the Rams are tied for first with Concord with six. McCarty said because the pitching's been doing well, the catchers are comfortable knowing where pitches will be and don't have to rush throws, helping them catch runners better.
The biggest problem for the Rams has been fielding. Shepherd's committed a conference-high 49 errors with a fielding percentage of .936.
Shepherd committed a team-high eight errors in a 8-5 win over Wheeling Jesuit in March but have been able to rely on the other strong aspects of the team to overcome the mistakes.
"Fielding needs to improve, but that comes with repetitions," McCarty said.
The team's been limited on its work outside because of the weather, and McCarty noted practicing inside and playing outside are very different. The team's also made a few moves around the field.
"I know our guys are working hard at it," the coach said, adding once they get outside more, he's confident in the defense.
After a four-game sweep of Glenville last weekend, the Rams moved to sixth in the National Collegiate Baseball Writers Association Division-II Atlantic-Region poll.
The Rams host back-to-back doubleheaders against Notre Dame this weekend as the regular season starts to wind down.
"We're slowly getting to where we want to be," McCarty said. "It's a slow process."


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Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.
What: Shares of Air Methods Corp. (NASDAQ: AIRM ) , a provider of air medical emergency transport services, rose as much as 17% after reporting its second-quarter earnings results.
So what: Last night's earnings report was certainly a mixed bag, so follow along and you'll find out exactly why shares are up so voraciously today. For the quarter, Air Methods reported just a 2% revenue increase to $226.2 million as net income declined by 39% (an adjusted profit of $0.52 per share). Patient transports also fell 9% this quarter from the year-ago period. Comparatively, the Street had forecast revenue of $229 million and EPS of $0.60. However -- and here's the big "however" of why Air Methods is up today -- poor weather accounted for a majority of the weakness in Air Methods' results, and the company anticipates a "meaningful improvement in future earnings" as weather improves and maintenance costs decline.
Now what: With the market being forward-looking, you can definitely say that today's move is purely based on guidance. Weather is sometimes a forgivable scapegoat, but it won't fly as an acceptable excuse more often than it will in the financial world. With patient revenue per transport once again on the rise and the company projection a return to meaningful earnings growth, I think that even after today's pop Air Methods could represent a solid bargain and would suggest interested investors dig deeper into this company.
Curious about another stock that could be ready for takeoff? Then I'd suggest reading up on The Motley Fool's chief investment officer's No. 1 stock for this year. You can find out which stock it is in the special free report: "The Motley Fool's Top Stock for 2013." Just click here to access the report and find out the name of this under-the-radar company.