text:
There's No Such Thing as a 'Boy Color' or 'Girl Color'
After the birth of the Royal Baby, our months of speculation over its sex—A boy? A girl?—will end. But depending William and Kate's use of family heirlooms, the baby might wear pink either way. Historically, before pink became considered a feminine color, it had masculine connotations, too.
Despite today's gender-reveal parties and hyper-girly and boyish baby clothes, it wasn't that long ago that parents dressed infants differently. Some friends recently mentioned that the family christening gown passed down over a few generations — and worn by more than one baby boy — featured pink ribbons. Their son had recently worn it for his baptism. Not only did many of our ancestors once deem pink acceptable for both sexes and even a "strong" color, blue was often seen as appropriate for girls and women, partly due to its association with the Virgin Mary.
As Jo Paoletti recounts in her fascinating history of children's clothing, Pink and Blue: Telling the Boys from the Girls in America, the word "pink" didn't even initially connote a hue and only joined the color vernacular in the mid-19th century. Until the early 20th century, most American babies wore long, white gowns favored for both their practicality (easy to bleach and starch) and lack of gender specificity. When pastels did decorate babies' clothing or nurseries, "pink and blue were suggested as interchangeable, gender-neutral 'nursery colors.'" If a parent did favor one or the other shade, it might depend on the child's coloring.
Though pink and blue began to acquire "gender coding" in the latter half of the 19th century, Paoletti reports that it took almost 100 years for people to uniformly interpret the colors the way we do today. During those days, adults were more concerned with distinguishing adults from children than they were little boys from little girls. Not until age four or five might boys begin to wear clothes that aped their fathers' fashions; before then they often wore dresses largely indistinguishable from those worn by their sisters.
But however much Americans gradually came to perceive pink and blue in such a fashion, this did not make our gender coding globally ubiquitous. "Baby clothes in other countries were still following a variety of rules," Paoletti writes, "meaning that imported items or gifts from overseas continued to observe their own traditional patterns…. Blue was still a 'girl' color in Switzerland, and pink was an acceptable color for baby boys in Korea in the 1980s." (Nor are cultural color differences limited to our baby pastels. The rainbows I see frequently in San Francisco have a very different meaning in Peru, where I saw similar flags in Cusco as a nod to the city's Inca heritage.)
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Created in this Craftsy class
Digitizing Machine Embroidery Designs taught by Cookie Gaynor
If you can dream it, you can embroider it! Cookie Gaynor shows you how to use your embroidery machine software to turn your original designs into a fully-stitched reality.
Other projects made as part of this class:
EmbroideryApplique Butterfly
EmbroideryFlower Sample
EmbroideryUsed 6D instead of my Premier Plus Extra
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
|Here are some details about my project:
|Classic, Casual
First stab at this
11/19/2013 Flag
Roni, It is a very nice first stab.One suggestion: have the body stitch after the candle wicking and wing embellishment which will eliminate the one dot on the body. You are on the right track, congrats! Tip: as soon as you have an element where you want it, group it so it can't be moved by accident. Love the colors, hot pink and purple are my favorites! Thanks for sharing.~ Cookie
11/26/2013 Flag

subset: commoncrawl


text: A frictionless rollercoaster is given an initial speed of voat height h, as in the figure. The radius of curvature of thetrack at point A is R. (a) Find the maximum value of vo so that theroller coaster stays on the track at A solely because of gravity.(b) Using the value of vo calculated in (a), determine the value ofh' that is necessary if the roller coaster just makes it to pointB.


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Spencer Perez beating Cedar Grove in a game that change the way Hoboken's future. And made him the best QB in the state of New Jersey that nobody knew about.
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CHI Auto Digital Ceramic Waver
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Works, But...
This thing definitely works, and works fast to deliver a "large crimped" look; would be great for structured waves around the face for a low bun type style. But I'm not going for that type of look; and with my waist length blond hair, I looked like the mermaid in "Splash"--it's not a natural effect, though it's great for a fun look. I returned it to where I had gotten it on sale--I'm sticking with my 1.5" curling iron.
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I tried several wavers, about 2-3 and found this one to satisfy me. i loved that it was ceramic because my hair is so damaged as it is. I've only tried it once so far, but seemed to work for me.
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Chi Ceramic Waver
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In reply
We respectfully disagree with Di Lernia's comment that patients with pilar MF, F-MF, or folliculotropic cutaneous T-cell lymphoma (CTCL) "should always be considered to have tumor-stage disease."
We are familiar with the 2002 article by van Doorn et al1 that describes 51 patients with F-MF who had disease-specific survival rates of 68% at 5 years and 26% at 10 years and posits that the prognosis for F-MF is similar to that for epidermotropic tumor-stage disease.1 However, Di Lernia did not cite 2 more recent reports that give much better survival rates for F-MF. In a 2005 report,2 the European Organization for Research on the Treatment of Cancer classifies F-MF as a distinct subgroup. The 5-year survival rate of 86 patients with F-MF is reported to be 80%, while that of 800 patients with classic MF is 88%.2 A 2008 report by Gerami et al3 comparing a United States group of 43 patients with F-MF to age- and stage-matched patients with epidermotropic MF found that those with early F-MF (up to and including stage IIA) had a 10-year survival of 82% and a 15-year survival rate of 41%. The 43 control patients who had epidermotropic MF had a 91% survival rate at both 10 and 15 years. However, patients with later-stage F-MF (stage IIB or higher) had outcomes similar to those with conventional epidermotropic MF of a similar stage. And the 10-year progression-free survival rate was 25% in the patients with stage IIB or higher F-MF compared with 8% in the epidermotropic MF group. While the authors conclude that F-MF is a more aggressive variant of CTCL, especially in the early stages, there was no evidence of worse prognosis in stage IIB or more advanced disease.
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More importantly, will a suspension deter Kronwall from going after monster hits again?
that's my concern as well.
however, i think it's well regarded that kronwall is not a dirty player (though some who have been embarrassed by him *cough* sellanne *cough* might say otherwise). although a suspension would give him a 'history,' i don't know if he could take that element out of his game. he's so good at hitting people and really does seem to enjoy it.
the game is so fast it's impossible to line up for those kinds of hits and pull out at the last second. it's two big bodies coming directly together, and if the dude is leading with his head well, DING. you're not targeting somebody's head if you go to hit his body and that's what is sticking out.
the chasing around and escorts off of the ice were embarrassing. our powerplay is horrendous; nobody can step in and say "you really want to fight? how about me?" janik?
if i were kronwall, I'd be a little concerned about getting cheap-shotted as a result from one of those hits. what do these other teams have to fear?


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#64 - ariscorp
Reply +21(05/09/2013) [-]
#121 to #64 - restfullwicked (05/09/2013) [-]
actually wales isnt one of the united kingdoms. its kingdom is the same kingdom as england.
#140 to #138 - restfullwicked (05/09/2013) [-]
yea but its not. its part of Britain, not the united kingdom.
#146 to #143 - restfullwicked (05/09/2013) [-]
no im not. Wales hasnt been a kingdom for almost a thousand years. that means that when the english monarch came to rule over every kingdom of britain, wales wasn't one of them because it is the same kingdom as England. So again. Wales is not part of the United Kingdoms because it is not a kingdom of itself.
the full title that we hardly use anymore is the United Kingdoms of Great Britain, Scotland, and Northern Ireland.
Wales has never been included in the title because it is not a kingdom.
the full title that we hardly use anymore is the United Kingdoms of Great Britain, Scotland, and Northern Ireland.
Wales has never been included in the title because it is not a kingdom.
#234 to #146 - theomegashade (05/13/2013) [-]
We've still got a king. he's just hibernating. In a cave. with Merlin. and Arthur
#235 to #234 - restfullwicked (05/13/2013) [-]
well since Arthur was welsh anyway chances are good.
#159 to #146 - mutzaki (05/09/2013) [-]
The official title is actually The United Kingdom of Great Britain and Northern Ireland. It's funny, because your misinformed title doesn't make sense to have "...of Great Britain, Scotland..." seeing as how Scotland is part of Great Britain. You see, that title would mean that Scotland isn't part of Great Britain, but still the UK, but that's only the case of N. Ireland.
Wales joined up with England in a union, which was the beginning of the UK.
Wales joined up with England in a union, which was the beginning of the UK.
#107 to #91 - AreyouSerious (05/09/2013) [-]
What about North Ireland? That's still under British Parliament's control isn't it?
#109 to #108 - AreyouSerious (05/09/2013) [-]
Brits should just sell it back to Ireland, I mean is there anything important there.
#113 to #112 - AreyouSerious (05/09/2013) [-]
#191 to #113 - windorigins (05/09/2013) [-]
Religion man, it's always about that
#118 to #103 - lordmoldywart
Reply +7(05/09/2013) [-]
Oh no, an Irish person with an ignorant prejudice about the British because of incidents that happened decades before he/she was even born


text:
© 2002 International Business Machines Corporation. All rights reserved.
Dan Wolfson's previous articles for the DB2® Developer Domain, Using MQSeries® from DB2 Applications, and DB2 MQ XML Functions: Using MQSeries and XML Extender from DB2 Applications, have generated a lot of response from our readers. Here are some of the questions Dan has received:
DB2DD Reader: Is there any message size limitation when messages are sent to MQSeries (WebSphere® MQ) via the DB2 interface? Currently, when messages are sent via the CICS® interface, one is limited to the 32K ceiling of the COMMAREA. This gives us a segmentation problem - and this may solve it.
Dan Wolfson: The first set of functions we delivered supported a 4000-byte maximum message size. However there is an additional, newer set of functions that support 1MB CLOBs. Information about these functions can be found in the release notes for DB2 UDB V7 Fixpack 4. The XML MQSeries functions have also been extended to support CLOB values. For details, see the release notes for DB2 XML Extender Fixpack 4.
DB2DD Reader: Do the MQ Series extensions that enable WebSphere MQ (MQSeries) messaging to integrate with database applications apply to DB2 for OS/390® and z/OSTM?
Dan Wolfson: When I initially wrote that article, the functions (like MQSEND, MQRECEIVE, MQPUBLISH, MQSUBSCRIBE, and so on) were available only on DB2 Version 7.2 of Windows®, AIX®, Solaris®, and HP/UX®. They are of course also available on those platforms in V8. I'm happy to report that several of the functions have been ported to DB2 on z/OS and OS/390 Version 7, including MQREAD, MQREADCLOB, MQRECEIVE, MQRECEIVECLOB, MQSEND, MQREADALL, MQREADALLCOB, MQRECEIVEALL, MQRECEIVEALLCLOB. Notice that the CLOB functions, which provide the capability to have message sizes larger than 4000 bytes, are also available on this platform. These functions are available with PTF UQ71197 and the DB2 for OS/390 manuals are updated, specifically the V7 Application Programming and SQL Guide, SQL Reference, and Installation Guide.
The 390 implementation also supports transactional integration (because of the RRS support on that platform). The first release for 390 will not include all of the XML integration features since we are trying to get the base functions out as quickly as we can. We plan to follow the first shipment with a second delivery covering the functions related to XML Extender, and the other pub/sub functions as quickly as we can.
DB2DD Reader: When would I use one-phase commit as opposed to two-phase commit?
Dan Wolfson: Currently, MQSeries functions support two-phase commit only on DB2 Universal Database for OS/390 and z/OS. For DB2 for OS/390 or x/OS, there are UDF versions that support one-phase commit and two-phase commit. Here are some issues you might want to consider when choosing one or the other:
MQSeries functions that support single-phase commit: When your application uses single-phase commit, DB2 COMMIT or ROLLBACK operations are independent of MQSeries operations. If a DB2 transaction is rolled back, the messages that have been sent to a queue within the current unit of work are not discarded. This scenario is useful in the case of application error. You might want to use MQSeries messaging to notify a system programmer that an application error has occurred. The application issues a ROLLBACK after the error occurs to roll back the DB2 work, but the message is still delivered to the queue that contains the error messages.
MQSeries function that support two-phase commit: If your application uses two-phase commit, RRS controls the commit process. If a DB2 transaction is rolled back, the messages that have been sent to a queue within the current unit of work are discarded. For example, assume that a sales transaction that is recorded in a DB2 database causes an MQSeries message to be sent to a queue. The message in turn causes your inventory system to order replacement merchandise. That message should be discarded if the transaction representing the sale is rolled back. In the two-phase commit environment, if you want to force MQSeries messages to be added to or deleted from the message queue, you need to issue a COMMIT in your DB2 application program.
DB2DD Reader: Why would I use these functions as opposed to writing my own MQ application?
Dan Wolfson: I think the primary reason is that you can easily combine queueing and database operations in the same SQL statement. So you can use a single simple SQL statement to publish the contents of a column or table as a message
(select mqsend(lastname) from employee) or insert the contents of a queue into a table
(insert into t values (select * from table (mqreceiveall()) t) ). You can embed messaging statements in triggers..etc. In addition, client applications can utilize this functionality without needing MQ on their machines; MQ only needs to be installed at the DB2 server.
Also, obviously, there's the ease of system integration effort and the performance enhancement you can achieve when MQ UDFs are used vs. writing your own MQ applications. The interface to MQ UDFs is simple to understand and configure, and the use of available UDFs whenever possible is a common practice.
DB2DD Reader: What is involved in setting up the AMI configuations?
Dan Wolfson: This generally includes setting up the enviornment variable AMT_DATA_PATH, the AMI host file
amthost.xml, as well as the repository file
amt.xml. The MQ UDF's enable utility program shipped with DB2 UDB (enable_MQFunctions) will perform a default configuration for you once you have the AMT_DATA_PATH set up to indicate where you want the host file and repository file kept in your AMI configurations. You can also customize your own configuration once you have a better understanding of how AMI works.
For DB2 z/OS or OS/390, you need to copy and customize the
DSNAMT and
DSNAMTHT files which are located in
DB2DD Reader: What is available to help with parsing the message?
Dan Wolfson: For DB2 on distributed platforms, we have a set of MQ UDFs and UDB Stored Procedures (SPs) shipped as part of the DB2 XML Extender that handles XML type messages. These SPs provide support to parse XML messages in the queue and store the elements' values to a set of predefined DB2 tables. (The reverse operation that constructs XML messages from tables is also availble.) The mapping is based on the DAD file that is provided as input parameter to the SPs. Please refer to the the XML extender documentation for more detailed information.
There is also support in the Development Center to generate table functions that automatically parse positionally defined or delimited messages.
DB2DD Reader: Can we use the basic DB2 and Websphere MQ Integration to pass an SQL update statement to DB2 from MQ, or do we need MQSI to do this?
Dan Wolfson: You need MQSI to do this. There is some additional functionality planned that will simplify this interaction, but for the moment you would either have to use MQSI or write your own application.
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text:
This pizza made everything worse, and then it made everything better. It was kind of a roller coaster that went something like this:
I have a busy week at work and though I have all the ingredients for this amazing-sounding peach pizza, I haven't gotten around to making the pizza dough I had intended to make (worse). No worries, I will just put the baby to bed and stop by Sendik's to buy some fresh dough (better).
I circle the store, searching high and low, but cannot locate their fresh pizza dough (worse). Nice manager walks me over to where the pizza dough is, telling me it is so. freaking. good. (better!) My mouth starts to water. We arrive at the dough location (doughcation?) and they're all out (worse. much worse). Nice manager says they have more in the bakery (better). We walk back to the bakery and no, they do not have any more dough in the bakery (worse).
I give up and buy refrigerated Pillsbury dough in a can (wah wah).
Back at home, I preheat the oven, roll out the dough on the counter and arrange balls of fresh mozzarella and thinly sliced peaches in perfect spacing on the pie. It is exquisite (better). Only one problem: there is no way I can get this pizza onto the oven rack without it completely falling apart (worse). What was I thinking rolling it out on the counter?! I briefly contemplate eating it raw because I am supremely hungry at this point and don't see how the situation can end well (worse).
(10 minutes of prep time, that is – there's no quick way to let it rise.)
Most experienced homemakers have at least a few recipe staples that are in the dinner rotation regularly. I would hesitate to say I'm at that point yet, though.
I like to try new recipes. This is what happens when you constantly bookmark blog posts, pin recipes and browse cookbooks. There is so much good stuff out there (or at least pretty food pictures) that I don't regularly find myself turning back to old recipes – until recently, that is.
Now that I've started meal planning and cooking dinner more regularly and intentionally, I've found myself bringing a tried and true recipe into the weekly meal plan every week. And more often than not, that recipe is homemade pizza.
I hope my son doesn't turn out to be one of those kids who you have to trick into eating vegetables.
Being married to a supertaster, I realize that picky eaters aren't always picky because they're not adventurous – if they have sensitive taste buds then they just can't help being turned off by certain strong flavors. But natural taste tolerances aside, I plan on giving vegetables a very good reputation in our house, so my son will hopefully have nothing to fear about spinach or zucchini.
This is one of those recipes that give zucchini a good name.
I call them zucchini pizza sticks, and I would have devoured the whole pan if I weren't so intent on saving some for lunch the next day so I could enjoy them once again.
Phew. If you're like me you feel like you just made it to a resting point after a marathon of holiday eating, baking, eating, eating and eating.
Turkey, ham, COOKIES, super-sweet potato casserole, sweet rolls, pie, chocolate, did I mention COOKIES?
I haven't quite finished the race yet, because there's still another weekend of indulgence ahead, but here I am with a few days of normal routine to give me a break.
Thank goodness.
I'm in the mood to keep it simple this week. That could mean frozen pizza and a salad. Or it could mean this pizza and a salad.
Here are some of my favorite recipes that I've blogged about.
Soups & Chili
Slow Cooker
Main meals
"I officially challenge myself, and all who wish to join me, to try a new fruit or veggie from a farmers market at least twice a month from now until the end of the summer."
Farmers Market Reviews:
Here's a list of some local food blogs. Wisconsin food bloggers, send me an e-mail if you'd like to be included on this list.
Wisconsin Food Blogs:
Other Wisconsin Blogs I Read:
Other Food Blogs I Read:
For your convenience, the same email address and password can now be used to:


text:
We showed you five cool-season crops to grow in your garden in the November 2007 issue of BIRD TALK magazine. Here are four warm-season crops to consider for your garden.
Before You PlantWarm season crops are best planted in late spring. They require temperatures above 60 degrees Fahrenheit to thrive in. Wait until the last frost in your area has passed before you begin planting or transplanting these crops. These crops do not tolerate extreme cold and they may be damaged if exposed to cold temperatures. Check the USDA Plant Hardiness Map to find out your region's hardiness zone and average annual minimal temperature range.
Sweet Pepper (Bell Pepper)Capsicum annuum
Nutritional Value: Vitamin A, Vitamin C, Vitamin K, Potassium
Planting Tips: Plant seeds mid-April through early June. Sweet peppers are best started indoors and then transplanted outside after the last frost date for your area. Place seedlings 18 to 24 inches apart. Sweet peppers require a lot of direct sunlight to grow healthy.
Basic Care: Sweet pepper plants prefer moist soil. Add mulch around the peppers to help retain moisture. Sweet peppers can be harvested as soon as they reach a size that is edible. Continuous harvesting will encourage your plant to produce more peppers, and you may get a fall crop from your sweet pepper plants.
Serve To Your Bird: Wash and chop the sweet pepper. Place it on a kabob for a fun treat for your bird.
Hot Pepper (Chili Pepper)Capsicum baccatum
Planting Tips: Plant seeds mid-April through early June. Hot peppers can be started from seeds or started indoors and transplanted outdoors. However, don't plant in your outside garden until after the last frost date for your area. Place seeds 1 ½ to 2 feet apart.
Basic Care: Hot pepper plants require good air circulation, sunlight and moist soil. As your plant begins to grow, support it with garden twine tied horizontally around slender wooden stakes situated around the plant. As they begin to mature, harvest your hot peppers by cutting them off with hand clippers or scissors. Depending on the type of pepper you have planted, you can begin to harvest them while they are green. Hot peppers turn red when fully ripe.
Serve To Your Bird: Wash and dice your hot peppers, and add them to your bird's favorite birdie bread recipe.
PumpkinCucurbita pepo
Nutritional Value: Vitamin A, Vitamin C, Vitamin E, Iron
Planting Tips: Plant pumpkin seeds in late May to early June. You'll need about 50 to 100 square feet to grow pumpkins in your yard. Plant four to five seeds per a planting hill, in rows that are 10 to 15 feet apart. Basic Care: As seedlings mature, thin to two or three strong plants per planting hill. Pull weeds from around the plants and use a hoe between rows. Pumpkins can be harvested when they are a deep, solid orange color and the rind is hard. Cut pumpkins from the vines using pruning shears or a sharp knife. Leave around 3 to 4 inches of the stem attached.
Serve To Your Bird: Peel off the hard skin and chop up into cubes. Boil pumpkin cubes and let cool. Serve the soft, warm cubes to your bird. Lightly sprinkle cinnamon or nutmeg on top for a different taste.
Winter Squash (Butternut Squash)Cucurbita moschata
Nutritional Value: Vitamin A, Vitamin C, Vitamin E, Potassium
Planting Tips: Plant winter squash seeds in April through July. Plant one to two seeds in rows that are 10 feet apart. There should be about 8 inches between planting hills.
Basic Care: As seedlings mature, thin to a single plant per planting hill. Pull weeds from around the plants and use a hoe between rows. Winter squash can be harvested when the squash has turned a deep solid color and the rind is hard. Harvest your main crop in September or October, before the first frost hits your area. Cut squash from the vines and leave about 2 inches of stem attached.
Serve To Your Bird: Wash and slice squash into strips. Bake in your oven and let strips cool before serving them to your bird.
*Content generated by our loyal visitors, which includes comments and club postings, is free of constraints from our editors' red pens, and therefore not governed by I-5 Publishing, LLC's Gold Standard Quality Content, but instead allowed to follow the free form expression necessary for quick, inspired and spontaneous communication.
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As Immunotherapy Revolutionizes the Cancer Treatment...
Quadruple Helices Appear To Have Role...
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Wall Street Decline Takes Its Toll...
Just as important, though, is that Luminex can do that not just with proteins like cytokines—one of the platform's original target markets—but can query samples at the genetic and gene expression levels as well. For cytochrome P450, for example, "we have some larger assays that look at a lot of different alleles and then narrow down the key markers that are important for predicting response to different drugs like Warfarin," Dr. Dunbar said. These kinds of studies allow the small contributions of individual or clusters of biomarkers to be teased out from otherwise impenetrable background noise.
More than 8,000 systems have been placed over the last 12 years, with over 50 Luminex assays having been approved for in vitro diagnosis by the FDA—including one for HLA matching that has "kind of become the gold standard," Dr. Dunbar noted. Such a track record reduces the risk associated with regulatory clearance.
Due to duration of a study, kit shelf life, and other factors, it is not unusual for samples for quantification of a biomarker study to be run on different lots of immunoassay kits in support of both preclinical and clinical studies. Yet for a variety of reasons—going up and down the supply chain of critical reagents that go into them—"there is quite a bit of variability in terms of the quality of these commercial kits," laments Afshin Safavi, Ph.D., senior vp of BioAgilytix Labs.
Even home-brewed assays rely heavily on the critical reagents, he pointed out. "We don't call it a kit, but in essence we are developing a kit in our shop internally."
Like it or not, the researcher needs to shoulder some of the burden of making sure the kits perform the same way lot-to-lot, year-to-year—and if not, to come up with systems to bridge the data that are generated by different lots.
To do this, Dr. Safavi recommended at a minimum running a series of quality controls and samples in both old and new lots. For larger studies "our practice is actually to repeat the lot-bridging process over three consecutive days, and that way you generate a larger number of data points that are more statistically significant," he said. "And then we come up with a correction factor…to normalize that data to the previous lot."
With the trend to multiplex assays, the bridging process becomes more critical than ever because the panel of proteins included in different biomarker kits comprising a multiplex assay do not always vary in the same way as each other from lot to lot, Dr. Safavi observed.
When applying a correction factor, it is important also to know what kind of tolerance there is for differences, and this can depend upon the intended use of the kit, the disease area being supported, as well as the changes you may predict, he says. If a 500% change is expected due to drug treatment, 40% variability is not going to have much effect on the decisions likely to be made based on the test, but if a 20% change is expected due to drug treatment even a 5% change may affect the quality of the data generated and impact the decision process.
Dr. Safavi was quick to emphasize that his comments applied only to research kits used in biomarker studies. "When it comes to pharmacokinetics or immunogenicity assays, they have their own sets of processes for qualifying and bridging reagents and assays and lots."
Tests developed in a regulated environment generally adhere to much tighter tolerances, with far more involved in their validation. When Roche developed the cobas 4800 BRAF V600 mutation test as a companion diagnostic to the metastatic melanoma therapeutic Zelboraf, for example, "no less than 25 analytic performance verification studies were required by the PMA [FDA premarket approval] process as well as for European and other regulatory agencies," recalled Walter Koch, Ph.D., vp and head of global research for Roche Molecular Diagnostics. "Multiple labs, multiple operators, multiple reagent lots over different days, with over 1,400 samples, all showed that the test was highly reproducible."
Development of the diagnostic and the drug proceeded together apace, taking a mere five years from the IND to their approval last year—"those are pretty much record times, I think," Dr. Koch said. "It shows the power of patient selection if you've got a good hypothesis of the biomarker, a good drug target, and a good drug that hits that target."
The assay, based on extracting DNA from FFPE samples for PCR, had its challenges to overcome, he pointed out. Formalin reacts with nucleic acids and causes them to degrade ("in the worst case only as much as 10% of the DNA is amplifiable"). Melanin in these highly pigmented cells is an inhibitor of PCR ("we had to devise sample-preparation strategies that eliminated the melanin from carrying into the PCR reactions"). And tumor tissue is heterogeneous and may contain different percentages of tumor content (and "not necessarily all the tumor cells have mutant copies—you can have mixed populations").
After all that, Roche had a conundrum. The FDA required it to compare the test results with Sanger sequencing, which can miss mutations found in less than about 25% of cells. The cobas test, on the other hand, was able to detect down to about 5% of cells carrying the mutated BRAF gene. Dr. Koch explained: "Our clinical trials had shown that those patients benefited from the drug. Yet the gold standard said, 'Oh, you've got a false negative or a false positive'." The issue was ultimately resolved by validating the procedure against 454 next-gen sequencing. "That was a challenge, because the agency had not looked at such data before."
Dr. Koch believes that targeted therapies and companion diagnostics are becoming inextricably linked. He urges coordinating and aligning their development from the beginning, and making sure that the diagnostic is in place and ready to go for the start of pivotal trials.
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Police: Man uses heroin in bathroom, then arrested
Auburn officerS respond to medical office
A 20-year-old man was arrested after he used heroin inside an Auburn office bathroom, then again outside a nearby home, police said.
Connor Morris, of Auburn, walked into a building on Grass Valley Highway. Officers with the Auburn Police Department got reports on Wednesday of some suspicious activity at the office.
Police said Morris walked into the medical office and injected heroin. He left behind paraphernalia outside the bathroom when he left.
He then trespassed outside a nearby home and used the drug again on the patio, police said.
When officers contacted Morris on Grass Valley Highway, they arrested him on suspicion of being under the influence of a controlled substance and drug possession.
Copyright 2013 by KCRA.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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The Mount Washington Cog Railway is a national historic engineering landmark, and it could be coming to your house, thanks to LEGOS.
Someone has designed the Cog and submitted it through the LEGO Ideas project.
The design features the Peppersass engine and boiler, and decals are in the works.
If the idea gets enough support on the LEGO Ideas website, it could become a reality, and the designer hopes to make that happen in time for the 150th anniversary in 2016.


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Words of the Huron
Paper 282 pp.
Release Date:
Online discount: 25%
$42.99 $32.24
Words of the Huron is an investigation into seventeenth-century Huron culture through a kind of linguistic archaeology of a language that died midway through the twentieth century.
John L. Steckley explores a range of topics, including: the construction of longhouses and wooden armour; the use of words for trees in village names; the social anthropological standards of kinship terms and clans; Huron conceptualizing of European-borne disease; the spirit realm of orenda; Huron nations and kinship groups; relationship to the environment; material culture; and the relationship between the French missionaries and settlers and the Huron people.
Steckley's source material includes the first dictionary of any Aboriginal language, Recollect Brother Gabriel Sagard's Huron phrasebook, published in 1632, and the sophisticated Jesuit missionary study of the language from the 1620s to the 1740s, beginning with the work of Father Jean de Brébeuf. The only book of its kind, Words of the Huron will spark discussion among scholars, students, and anyone interested in North American archaeology, Native studies, cultural anthropology, and seventeenth-century North American history.
John L. Steckley has taught at Humber College since 1983 in the areas of Aboriginal languages, culture, and history. His books include: Beyond Their Years: Five Native Women's Stories; Full Circle: Canada's First Nations; Aboriginal Voices and the Politics of Representation in Canadian Introductory Sociology Textbooks and De Religione: Telling the 17th Century Jesuit Story in Huron to the Iroquois. In 1999, he was adopted into the Wyandot tribe of Kansas.
"The book contains a wealth of both data and speculation. It illustrates some of the limits of even the best linguistic records from the past, as well as the potential results of supplementing linguistic materials with other kinds of evidence. It goes a long way toward meeting its aim of giving a voice to the Huron people."
— Clifford Abbott, University of Wisconsin—Green Bay, Anthropological Linguistics
"Steckley's work adds ethnolinguistics to the methods of research in Huron studies.... A fine example of original, intensive research.... Highly recommended."
— R. Berleant-Schiller, emerita, University of Connecticut, CHOICE
Related interest
By the same author
The Eighteenth-Century Wyandot: A Clan-Based Study, John L. Steckley


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Hearing aids in Adrian, MI
We found 12 hearing clinics with 54 reviews within 48.7 miles of Adrian, MI.
Featured hearing professionals near you
Erica Oswald, HIS, BC-HIS
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Petra has been an active Audiologist in the Detroit area for many years. She has recently (read more)
Thomas O'Connor, M.A., CCC-A, FAAA
Thomas O'Connor offers over 25 years of experience in audiometric testing and fitting hearing (read more)
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Joel earned his Doctorate in Audiology at the University of Florida after attending Central Michigan (read more)
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Larry Hand has been helping people hear better for over two decades. He is the owner and Licensed (read more)
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Karissa L. Jagacki, Au.D., earned her doctorate of Audiology degree from Central Michigan University (read more)
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Product Information
Home Marketplace Home Styles Americana Corner Nook Set
Find your own little corner of the world. When the sun is high in the sky or disappears below the horizon, you'll enjoy the natural beauty of this dining table. With diamond-shaped carvings and detail on the table apron, as well as shaped, sculpted ends on the tabletop and raised, carved detail on the pedestal base, its look is about as American as the apple pie you'll serve. What You Get Long bench Short bench Corner bench
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The European auto market continues at 20-year lows, with sales down 4% in January – September. Whilst September's sales appeared stronger, up 5% versus 2012, this was only due to Spain and the UK. Spain boosted volume by 10k due to a €2.7k ($3.7k) government hand-out for people trading in an older vehicle. Whilst UK volumes were up 40k due to a credit […]
Tag Archives | Tata
European auto markets head in a new direction
By Paul Hodges on 23 October, 2013 in Consumer demand
Paul Hodges is Chairman of International eChem, trusted commercial advisers to the global chemical industry.
The aim of this blog is to share ideas about the influences that may shape the chemical industry over the next 12 – 18 months. It will try to look behind today's headlines, to understand what may happen next in important issues such as oil prices, economic growth and the environment. We may also have some fun, investigating a few of the more offbeat events that take place from time to time. Please do join me and share your thoughts.
Between us, we will hopefully develop useful insights into the key factors that will drive the industry's future performance.
auto sales Bank of England BASF benzene Brent Brent oil prices central banks China Chrysler consumer spending credit bubble credit crunch crude oil prices deflation Dow Chemical ethylene European Central Bank Eurozone Federal Reserve Ford global downturn GM housing IMF India inflation interest rates Japan liquidity naphtha new normal oil prices OPEC Petrochemicals Polyethylene polymers PTA recession Russia S&P 500 stimulus Toyota unemployment USA US Federal Reserve


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Arts & Life
The HOT list: See 18 things that have FD Luxe's editors palpitating and perplexed
Photo: FD Luxe
And you think the temperatures are sizzling? Presenting 18 things that have FD Luxe's editors and contributors palpitating and salivating, perplexed and peeved.
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It's official: Jay Paterno will not be retained as Penn State's quarterbacks coach
The Associated Press By
on January 10, 2012 at 5:27 PM, updated January 12, 2012 at 2:36 PM
on January 10, 2012 at 5:27 PM, updated January 12, 2012 at 2:36 PM
The younger Paterno worked the last 12 seasons as the quarterbacks coach. His departure was expected after the school last week named New England Patriots offensive coordinator Bill OBrien to succeed JoePa as head coach. Paterno was fired Nov. 9.
In a statement, Jay Paterno said he spoke with OBrien and that the two reached the conclusion he would not be part of the new staff. He said he would spend the next few weeks consulting his wife and family about options both inside and outside of football.
Jay Paterno thanked fans for their support and wished good luck to the program.


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This material must not be used for commercial purposes, or in any hospital or medical facility. Failure to comply may result in legal action.
Arm Fracture In Children
What is an arm fracture?
An arm fracture is a crack or break in one or more of the bones in your child's arm.
What causes an arm fracture?
The following are the most common causes of arm fractures:
- Trauma: A direct hit to your child's arm may cause a fracture. Car and sports accidents are some examples of trauma that can cause an arm fracture.
- Fall: The pressure when your child lands on his hands after a fall may cause his arm bone to break.
- Stress fracture: This is a tiny fracture that happens when your child's arm muscles become tired from overuse. Stress fractures happen most often during sports when the same motion happens over and over.
What are the different types of arm fractures?
- Nondisplaced: The bone breaks but the pieces stay in place.
- Displaced: The bone breaks, and the pieces move out of place.
- Open fracture: The broken bone breaks through your child's skin.
- Salter-Harris fracture: The bone breaks through your child's growth plate.
What are the signs and symptoms of an arm fracture?
- Arm and shoulder pain
- Swollen and bruised arm
- Abnormal arm position
- Severe pain when your child moves his arm
- Weakness or numbness in your child's arm, hand, or fingers
How is an arm fracture diagnosed?
Your child's healthcare provider will ask about his injury and examine him. Your child may need the following tests:
- X-ray: An x-ray will show the type of fracture your child has.
- CT scan: This test is also called a CAT scan. An x-ray and computer are used to take pictures of your child's arm. He may be given dye before the test. Tell healthcare providers if your child is allergic to iodine or seafood. He may also be allergic to the contrast dye.
- MRI: This scan uses a powerful magnet and a computer to take pictures of your child's arm. Your child may be given dye before the test. Tell healthcare providers if your child is allergic to iodine or seafood. He may also be allergic to the contrast dye. Your child will need to lie still during his test. Never enter the MRI room with any metal objects. This can cause serious injury.
- Bone scan: This is a test to look at your child's arm bones. He is given a small, safe amount of dye in an IV. Pictures are taken of his injured arm. The pictures will help healthcare providers see your child's arm fracture better.
How is an arm fracture treated?
Treatment will depend on what kind of fracture your child has, and how bad it is. He may need any of the following:
- Brace, cast, or splint: A brace, cast, or splint will decrease your child's arm movement and hold the broken bones in place. This will help decrease pain, and prevent further damage to his broken bones.
- Medicines:
- Pain medicine: Your child may be given medicine to take away or decrease pain. Do not wait until the pain is severe before you give your child his medicine.
- Antibiotics: This medicine is given to help prevent or treat an infection caused by bacteria.
- Physical therapy: A physical therapist can teach your child exercises to help improve movement and decrease pain. Physical therapy can also help improve strength and decrease your child's risk for loss of function.
- Surgery: Your child may need debridement before his surgery if he has an open fracture. Debridement is when damaged tissue is removed and the wound is cleaned. Debridement helps prevent infection and improve healing. Your child's healthcare provider will use pins, screws, wires, or other materials to hold the bones straight so they can heal. Your child may have pins coming out of his skin.
What are the risks of an arm fracture?
Your child's arm may not be straight, even after treatment. The nerves in his arm may be damaged, which can make his arm numb or weak. His arm may not heal properly or work as well as it did before your injury. He may have a scar if he has surgery.
When should I contact my child's healthcare provider?
Contact your child's healthcare provider if:
- Your child has a fever.
- Your child has new or worse trouble moving his arm.
- You have questions or concerns about your child's injury, treatment, or care.
When should I seek immediate help for my child?
Seek help immediately or call 911 if:
- The pain in your child's injured arm does not get better or gets worse, even after rest and medicine.
- Your child's arm, hand, or fingers feel numb.
- Your child's arm is swollen, red, and feels warm.
- You see blood on your child's splint or cast.
Care AgreementYou have the right to help plan your child's care. Learn about your child's health condition and how it may be treated. Discuss treatment options with your child's caregivers to decide what care you want for your child. The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.
© 2015 Truven Health Analytics Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. All illustrations and images included in CareNotes® are the copyrighted property of A.D.A.M., Inc. or Truven Health Analytics.
Learn more about Arm Fracture In Children
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More Independent Contractors Are Organizing. Meet Teamster Taxi Cabs
Washington D.C.'s taxi drivers are getting a union, kind of. Capitol city cabbies who belong to Washington D.C. Taxi Operators Association this week affiliated the group with Teamsters Local 922. Under the arrangement, the drivers' new association will transfer $23 per driver in monthly dues to the Teamsters, which will help it negotiate with city regulators. More than 1,000 of the city's 8,000 licensed hacks reportedly have joined the association, which uses the tagline "Teamster Taxi Cabs" at the top of its website.
The drivers, who own their cars, or lease them as independent contractors, are aligning themselves with the 1.4 million-member Teamsters at a time when independent contractors across industries are in the middle of regulatory maelstroms. As Jim Efstathiou Jr. reported earlier this month, states from California to New York are cracking down on companies that mislabel employees as contractors in a bid to save on payroll taxes and worker benefits. Employers often see it differently, arguing that contractor arrangements appeal to workers who prefer to set their own hours. While federal and state officials spar with businesses, it makes sense that independent workers would seek greater influence.
Teamsters spokesman Galen Munroe says the union doesn't see the situation with the D.C. drivers as a case of worker misclassification. Then there's the rise of startups like Uber, which has raised more than $300 million in venture capital, though Munroe doesn't credit the newcomers for prompting drivers to affiliate with his group.
While Munroe prefers to focus on relatively small regulatory headaches such as credit card transaction costs, the affiliation would also help with bigger ticket issues. "There's more power in numbers," he says. "Any time you have folks who are independent contractors, it's hard to speak with one voice."
Taxi drivers aren't new to labor unions. Before the industry structure shifted to the independent contractor model, drivers who worked as employees for cab companies were organized in many U.S. cities, says Catherine Ruckelshau, general counsel for the National Employment Law Project. Nor are hacks the only independent workers to organize to improve their bargaining positions. Some freelance writers and physicians are also moving in the direction of unionization.
Last year, Seattle cab drivers also affiliated with a Teamsters. Tracey Thompson, an executive at Teamsters Local 117, which represents more than 500 cabbies through an industry association, posits a grander regulatory battle than Munroe does. "Taxi operators are classified as independent contractors, but they are often treated like second-class employees," Thompson wrote in a June op-ed that cited Uber and Lyft as threats to her members. That stance makes sense. In the last year, tech companies have waged high-pitched battles over how the taxi business gets regulated. As industry incumbents and richly-funded startups flex their muscles, it makes sense for contractors to seek out more powerful friends.


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Judgment Against Wicked Kings
Judgment Against Wicked Kings
1 This is what the Lord says: �Go down to the palace of the king of Judah and proclaim this message there:
2 �Hear the word of the Lord to you, king of Judah, you who sit on David�s throne�you, your officials and your people who come through these gates.
3 This is what the Lord says: Do what is just and right. Rescue from the hand of the oppressor the one who has been robbed. Do no wrong or violence to the foreigner, the fatherless or the widow, and do not shed innocent blood in this place.
4 For if you are careful to carry out these commands, then kings who sit on David�s throne will come through the gates of this palace, riding in chariots and on horses, accompanied by their officials and their people.
5 But if you do not obey these commands, declares the Lord, I swear by myself that this palace will become a ruin.��
For this is what the Lord says about the palace of the king of Judah:
�Though you are like Gilead to me,
like the summit of Lebanon,
I will surely make you like a wasteland,
like towns not inhabited.
I will send destroyers against you,
each man with his weapons,
and they will cut up your fine cedar beams
and throw them into the fire.
8 �People from many nations will pass by this city and will ask one another, �Why has the Lord done such a thing to this great city?�
9 And the answer will be: �Because they have forsaken the covenant of the Lord their God and have worshiped and served other gods.��
Do not weep for the dead king or mourn his loss;
rather, weep bitterly for him who is exiled,
because he will never return
nor see his native land again.
11 For this is what the Lord says about Shallum[a] son of Josiah, who succeeded his father as king of Judah but has gone from this place: �He will never return.
12 He will die in the place where they have led him captive; he will not see this land again.�
�Woe to him who builds his palace by unrighteousness,
his upper rooms by injustice,
making his own people work for nothing,
not paying them for their labor.
He says, �I will build myself a great palace
with spacious upper rooms.�
So he makes large windows in it,
panels it with cedar
and decorates it in red.
�Does it make you a king
to have more and more cedar?
Did not your father have food and drink?
He did what was right and just,
so all went well with him.
He defended the cause of the poor and needy,
and so all went well.
Is that not what it means to know me?�
declares the Lord.
�But your eyes and your heart
are set only on dishonest gain,
on shedding innocent blood
and on oppression and extortion.�
Therefore this is what the Lord says about Jehoiakim son of Josiah king of Judah:
�They will not mourn for him:
�Alas, my brother! Alas, my sister!�
They will not mourn for him:
�Alas, my master! Alas, his splendor!�
He will have the burial of a donkey�
dragged away and thrown
outside the gates of Jerusalem.�
�Go up to Lebanon and cry out,
let your voice be heard in Bashan,
cry out from Abarim,
for all your allies are crushed.
I warned you when you felt secure,
but you said, �I will not listen!�
This has been your way from your youth;
you have not obeyed me.
The wind will drive all your shepherds away,
and your allies will go into exile.
Then you will be ashamed and disgraced
because of all your wickedness.
You who live in �Lebanon,[b] �
who are nestled in cedar buildings,
how you will groan when pangs come upon you,
pain like that of a woman in labor!
24 �As surely as I live,� declares the Lord, �even if you, Jehoiachin[c] son of Jehoiakim king of Judah, were a signet ring on my right hand, I would still pull you off.
25 I will deliver you into the hands of those who want to kill you, those you fear�Nebuchadnezzar king of Babylon and the Babylonians.[d]
26 I will hurl you and the mother who gave you birth into another country, where neither of you was born, and there you both will die.
27 You will never come back to the land you long to return�to.�
Is this man Jehoiachin a despised, broken pot,
an object no one wants?
Why will he and his children be hurled out,
cast into a land they do not know?
O land, land, land,
hear the word of the Lord!
This is what the Lord says:
�Record this man as if childless,
a man who will not prosper in his lifetime,
for none of his offspring will prosper,
none will sit on the throne of David
or rule anymore in Judah.�
Top 10 sermons on Jeremiah 22
- You Missed the Point
- You Missed the Point
- The Late, Great, Planet Earth.
Copyright � 1973, 1978, 1984, 2011 by Biblica, Inc.�
Used by Permission of Biblica, Inc.� All rights reserved worldwide.


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If you repeatedly ignore your credit company's inquiries about delinquent funds, your case may be turned over to a debt collector. This Act prohibits unfair, deceptive and abusive debt-collection practices. Out of respect for your privacy and to protect you from harassment, debt collectors:
- May only contact your lawyer, spouse, guardian, executor, and administrator or parent (if you are a minor) about your debt.
- May inquire of others about how to find you, however, any aggressive behavior or harassment is not allowed.
- May contact you only between 8 a.m. and 9 p.m.
- Must contact your lawyer instead of you if the debt collector knows you have retained a lawyer.
- Must identify himself or herself and the name of the debt collection company while collecting debts.
- May not contact you at work if he or she knows your employer disapproves.
- May not lie when collecting debts, for example, falsely implying that you'll be arrested.
- Must stop contacting you if you so request in writing. After that, the collector may contact you only once more, for example, to tell you what will happen next.
Additional Resources
Contact the United States Federal Trade Commission (FTC), Office of Consumer Protection at 202-326-3650, or online at www.ftc.gov for more information about consumer credit issues.
The Consumer Credit Counseling Service (CCCS) is a non-profit service that can also answer questions about credit. Contact them at 1-800-640-CCCS or online at www.cccs-inc.org.


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Wondering why you should apply to be a TED Fellow? Get an insider's view with MyFellowsStory. Today, tomorrow, and Wednesday we'll feature Fellows that will tell you what the program has done for them, the lasting relationships they've formed and those serendipitous moments that make all the difference.
MyFellowsStory :: Taghi Amirani
Iranian physicist turned filmmaker
TED2010 Senior Fellow
Amirani Media
Learn more about Taghi's work here.
Describe your work in 6 words (or less):
East meeting west through political cinema.
Describe one relationship you've made because of the Fellows program:
Too many amazing connections to pick one; the most precious is with some of the Fellows from my class of 2009 and the TED Fellowship team itself.
How is your life different today because of the program?:
Access to people and places that have made a huge difference to my work.
Describe the program in three words:
Connections connections connections
Most surreal TED conference moment?:
The whole TED thing is surreal. You step into a bubble. Winning the TED Fellows Hero Award tops the surreal moment list.
Why would you recommend the program?:
If TED enters your life at the right moment in your career, and you are prepared and willing to work at it, then it can have a significant impact on your work and life. As long as you remember it is just a conference, and as such, a microcosm of the real world.
Application tip?:
Be yourself and be true to yourself.
MyFellowsStory :: Anita Doron
Avalanche Films + Mashina Arts
Learn more about Anita's work here.
The Lesser Blessed Official Trailer from Gen One Films on Vimeo.
Describe your work in 6 words (or less):
I make people feel through stories.
Describe one relationship you've made because of the Fellows program:
J. Adam Huggins, a fellow Fellow and I were connected by the Fellowship team for having similar creative sensibilities in our work. Well, we discovered that those sensibilities spilled into every aspect of our lives and we became inseparable, living a semi-nomadic, joyfully uncertain life while creating, writing and co-organizing a TEDx conference in Brazil. Our greatest collaboration is Tian Huggins, a small human being of two years.
How is your life different today because of the program?:
No longer an armchair warrior, I've unlearned, absolved cynicism and came to see an absolute possibility and need to instigate massive shift.
Describe the program in three words:
Surpass your potential.
Most surreal TED conference moment?:
Spontaneously drawing a two-headed monster with architect Mitchell Joachim and musician Susie Ibarra while our hands were intertwined and then dancing with the incredible Saeed Taji Farouky and Daniel Zoughbie, forming three degrees of Shleparation, as Saeed coined it, a full Jewish / Palestinian spectrum.
Why would you recommend the program?:
If you have a deep desire to change the world and you no longer want to be inhibited by your own, misperceived limitations, become a TED Fellow.
Application tip?:
It is better to show your passionate, lunatic side than keeping it sensible.


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Devils forward Michael Cammalleri said Friday he has no problems with his right hand, which was injured and limited him to 42 games last season.
Training Camp: Day 2by Julie Robenhymer / NewJerseyDevils.com
With a split squad exhibition game just three days away, most of the players jumped right into training camp with both feet this morning for a 40 minute scrimmage. The 54 players presently in camp were divided into three teams as listed below with Team A facing Team B today, Teams B and C squaring off tomorrow, and Teams A and C going on Sunday for two scrimmages apiece.
Dynamic trio could be Taylor madeby Mike Morreale / NHL.com
NEWARK, N.J. -- Left wing Taylor Hall wants to bring speed and pace in order to be the player who can "tilt the ice" in favor of the New Jersey Devils this season.
Team USA loses finale to Czech Republicby Arpon Basu / NHL.com
TORONTO -- Team USA is leaving the World Cup of Hockey 2016 without a victory after losing to Team Czech Republic 4-3 in the final preliminary-round game at Air Canada Centre on Thursday.
Welcome to the 2016/17 NHL Season… Media Day Blogby Julie Robenhymer / NewJerseyDevils.com
If you ever wanted to be a fly on the wall in the locker room, I hope you tuned into our Facebook Live sessions from this morning with a birds eye view of the Devils All-Access Players Lounge during Media Day. The players kicked off training camp by running through a gauntlet of media outlets like NHL Network and MSG and, while waiting their turn for stops along the way, they hit up the players lounge to relax a bit or get their competitive juices firing on all cylinders with games of ping pong, NHL 17, mini air hockey and cornhole.
Devils announce Training Camp rosterby New Jersey Devils / newjerseydevils.com
The Devils have released the numerical roster for 2016 Training Camp set to begin on Thursday, September 22 at Prudential Center and Barnabas Hockey House at Prudential Center.
MSG Networks releases '16-17 Devils telecast schedule
81 regular-season games, two preseason games to be telecast on MSG Networksby New Jersey Devils / newjerseydevils.com
The Devils begin their 2016-17 campaign on October 13 when they visit the Florida Panthers for their first regular season matchup at 7:30 p.m. on MSG+
Devils sign prospects Blake Speers, Colton Whiteby New Jersey Devils / newjerseydevils.com
The Devils have signed forward Blake Speers and defenseman Colton White to three-year entry-level contracts. The announcement was made by Devils' Executive Vice President/General Manager Ray Shero.
Team USA downed by Canada
U.S. eliminated from contention as Canada reaches semisby Tom Gulitti / NHL.com
TORONTO -- Two games into the World Cup of Hockey 2016, Team Canada has clinched a spot in the semifinals and the competitive portion of Team USA's tournament is over.


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Over the past few weeks author and journalist Paul Tough and his new book How Children Succeed: Grit, Curiosity, and the Hidden Power of Character have been making a splash in the world of education reform. The book has been highlighted in the New York Times, on NPR, and on various other news outlets.
And then there was Education Nation. Brian Williams seems to have a major crush on all things Tough. And as always, the charter school franchise KIPP is mentioned in nearly every segment as a school "beating the odds". This year, all the hype was about KIPP's character education program. Williams later went on the do a Rock Central segment called "True Grit: Teaching Character in the Classroom".
Tough's book centers on the idea that critical non-cognitive skills, which he calls "character", can be hindered due to poor parenting and the stresses of…
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Featured Golf News
Birthplace of Champions Tour is Still a Great Test
Back in the late 1970s, golf fans became familiar with the Onion Creek Club in the southeastern suburbs of Austin after it hosted the Liberty Mutual Legends of Golf Tournament, the precursor to, first, the Senior Tour and later the Champions Tour.
Onion Creek's 12th Hole
(photo courtesy of Carlton Wade)
For 11 years, beginning in 1978, Onion Creek conducted the celebrated Legends tournament, as the course designed by Jimmy Demaret and founded by Texas amateur golf legend Jimmie Connolly in 1974 more than held its own before the great golfers of the black-and-white television days. These same players eventually brought the sport into the modern world with a dash of charm and savoir-faire.
The Legends of Golf tournament left Onion Creek in 1990, first for Austin neighbor Barton Creek and then for California and elsewhere. But the history of the event and its legendary players are still on display in its clubhouse and rustle through the huge trees that stand sentinel over the fairways and greens of the original 18-hole layout, which plays at just 6,351 yards and a par of 70. The original 18 is rated at 70.7 and slopes out at 132.
In 1996, two-time Master's champion and Austin native Ben Crenshaw and Bill Coore blended nine new holes with Demaret's original design, in the process creating one of the most beautiful tracks in Texas. With its gently rolling fairways shaded by towering cypress, oak and pecan trees that line the banks of Onion Creek, the current 27-hole track - which can be played in its original configuration or as a combo of the Demaret-Crenshaw/Coore design - is still a thrill to play and a shotmakers' heaven.
By design, Onion Creek plays at both a championship level and a member level, providing an enjoyable challenge to golfers of any age or handicap. Demaret used nature as the "architect" of Onion Creek Club. "I simply followed the natural features of the land," he said.
The nine holes crafted by Crenshaw and Coore are meshed into the original to form the North Course. When playing a full 18 on the North Course Nos. 10 through 13 of Demaret's original back nine serve as Nos. 1 through 4. After finishing on No. 13 (Original), aka No. 4 (North), you can go straight and continue playing the newer North Course, or turn left and play the Original Nos. 14 through 18. The clubhouse determines which 18 you can play.
At times over its history Onion Creek has turned into a river as heavy rains have swollen water from the creek over its banks. Floods have left holes under water and caused severe damage to the course. But after each flood the holes have been repaired and returned to their original form and kept in top condition, just like Demaret, who died in 1983, would have wanted.
With the new holes included, 13 holes feature the course's namesake. Nowhere is this more prominently displayed than on second through the eighth holes on the Original Course.
At No. 2, a picturesque 131-yard par-3, Onion Creek sits just behind the green for anyone who misjudges the 60-foot drop and airmails the putting surface. Because you really have to misjudge a shot to reach the water, this is probably the kindest location of the creek during this stretch of holes.
1st Hole at Onion Creek Club's Original Course
On Nos. 3 through 8, the creek is much more of a concern. Any errant drive to the right can find the water or - perhaps even more punitive - get lost in the wall of trees and vines that attempt to keep your ball dry. In addition to the creek, ponds come into play on Nos. 5, 9, and 10. On the fifth, a pond in front of the green runs down the entire left side. Three large bunkers are waiting for errant shots to the right, away from the pond.
Although water can make for many tough decisions throughout the 27 holes, so can the bunkers, which are placed liberally throughout the course. The location of that sand, both in the fairway and near the greens, can inflate your score. On a handful of Onion Creek's greenside bunkers, the front walls are some four feet tall.
Length can also be a factor on the Original Course, especially on the tough, dogleg-left 601-yard, par-5 seventh. Water is in play the entire way with Onion Creek along the right. Tall oaks border the narrow fairway along the left and force you to execute three precise shots to have any chance at par.
The 342-yard and downhill, par-4 12th - Onion Creek's signature offering - looks out over a narrow fairway some 50-plus feet below as the stream beckons on the right. The creek reappears on No. 16 as it runs the length of the hole down the right side.
The 414-yard, par-4 15th on the Original Course is always a challenge as a drive of 260 yards leaves you a mid-length iron over a chasm - often filled with water - to an uphill, off-camber putting surface.
The final two holes on the Original are among the track's most demanding, thanks to their elevated greens. The 17th is a reasonable 144-yard par-3 with a severely elevated tee box - be exact on your yardage as anything not close to the pin will probably result in a three-putt, either uphill to the tri-level putting surface or quickly downhill to a place that is perhaps Onion Creek's toughest hole location.
The closer is a 558-yard par-5 on which the approach is all uphill to a narrow green ringed by sand on three sides. Take two more clubs tha, you think on the third, especially if the pin is in the back.
The Crenshaw/Coore North nine sports some great offerings as well, especially the eighth and ninth, dual par-4s that play at 450 and 461 yards, respectively. I also like the two par-5s: the 526-yard fifth, which is reachable, and the grip-it-and-rip-it, 577-yard 12th. North stretches 6,530 yards and a par of 70 and carries a rating of 71.2 and a slope of 130 from its back set of five tees.
On both the Original and North, the Tifdwarf greens are relatively fast and the 419 Fairways give you a nice roll on solidly struck tee shots. In U.S. Open-like fashion, balls that fall into the rough along the fairway or near the green have a tendency to sink down into the turf and disappear, so be accurate.
Onion Creek Club features a three-facet practice facility. It has 31,000 square feet of teeing ground and is equipped with six target greens that vary in length from 40 to 225 yards depending on the location of the hitting stations. In addition to the range, there is a bunker and chipping green with a 6,000-square-foot green that is mowed to the same height as the course's putting surfaces.
Since Demaret first sent a golf ball rocketing down the No. 1 fairway, Onion Creek has held a special place in golf history. It's not the hardest course, but you have to be on your toes. Thanks to the various configurations, its relative flatness and overall beauty, the club's members don't get tired of playing it.
Demaret never saw the tournament he co-founded with Fred Raphael turn into the tour that today awards millions of dollars each year to the players over 50. But you'd have to think he is looking down and smiling at the way Onion Creek has survived and thrived after four decades.
After playing Onion Creek Club, you'll understand why the great players of past generations enjoyed it so much. It's a track for the ages - all ages that is - with a kindly nod to the past.
For additional information about Onion Creek Club, visit www.onioncreekclub.com.
Steve Habel is one of Cybergolf's national correspondents, contributing news stories, features, equipment and book reviews and personality profiles from his base in Central Texas. He is also the managing editor for Business District magazine in Austin and works as a contributing editor for Horns Illustrated magazine, a publication focusing on University of Texas sports. He also writes a blog (www.shotoverthegreen.blogspot.com), which features news on golf and the Longhorns.
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Not just a thiz user ima thiz owner
by Lisa February 23, 2005
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Can you define these popular missing words?
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Niggas in da club thizzin' of dat E.
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1. High off of extacy
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Thizzin doesnt just mean high it means going hella dumb having and going going till were gone (lyrics from Mistah F.A.B)
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by Beans-n-Fixins August 02, 2007
whenever you're trippin off of drugs.
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by riko suave` June 27, 2005


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I think you can catch a glimpse of me (my blonde head bobbing, at least). More importantly, you can hear them talk about my desserts! Unfortunately, I do not make the chocolate parfait, but I do make the Twinkees! How they are described as "not too sweet" is beyond me.
This is my second appearance on Check, Please Bay Area. I was also caught at Patxi's, stuffing my face. I'm a brunette in this one -- a regular secret agent!


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The panic reached its peak on St Valentine's Day. René Meulensteen had only been in charge of Fulham for 75 days. It was not yet three months since he had replaced Martin Jol. No matter. Shahid Khan, the club's owner, had seen enough. To lose one Dutchman might be unfortunate; to lose two looked remarkably like carelessness. Khan felt he had no other choice. The only other way was down.
He admitted as much in the statement he released that evening to accompany the news of Meulensteen's departure. "Felix Magath," he wrote of his replacement, "has a reputation for coming


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Jepson Center for the Arts
Savannah, GA 31401
Covered with glistening white Portuguese stone and consisting of two separate structures connected by glass bridges over a protected lane that is part of Savannah's town plan originally conceived in 1733 by Georgia's founder General James Oglethorpe, the building has a soaring, light-filled atrium and sweeping, three-level staircase that provides access to its expansive galleries. The Jepson Center for the Arts has a total of 14,000 square feet of additional exhibition and studio space that permit the Telfair to mount temporary exhibitions that are considerably larger than has been possible in the landmark Telfair Academy. Education is a vital element of the Jepson Center for the Arts. In addition to expanded studio space, a teacher and docent resource center, a community gallery, and the auditorium, the Jepson Center features a unique, two-level hands-on gallery especially for children and their families entitled ArtZeum. Designed to answer questions such as "What is art, anyway?" "Why do we make art?" "Why do we care so much about art?" And "What does art mean to me?" the gallery uses works from the Telfair's permanent collection and examples of Savannah architecture to challenge novice viewers to question their assumptions and explore "big ideas" about art.
Info & Amenities
Hours of Operation
Sunday: 12:00PM - 5:00PM
Monday: 12:00PM - 5:00PM
Tuesday: 10:00AM - 5:00PM
Wednesday: 10:00AM - 8:00PM
Thursday: 10:00AM - 5:00PM
Friday: 10:00AM - 5:00PM
Saturday: 10:00AM - 5:00PM
Admission & Fees
Adult $20
Children (12 & Under) Free
Military $18
Senior (65+) $18
Student $15
Facility Amenities
Concessions, Gift Shop, Guided Tours / Guide Available, Public Restrooms, Restaurant on Site, Self-guided Tours
General Information
Group Amenities
Suitable for Ages
All Ages
Elvis at 21: Photographs by Alfred Wertheimer
04/22/2016 - 10/02/2016
Taken during the year Elvis Presley turned 21, Alfred Wertheimer's photographs are a remarkable visual record of rock 'n' roll's most enduring figure. When Elvis walked on stage in 1956, time stopped-and then exploded. The earth shook on its axis and the beat of everyday life was jolted. In an instant, mainstream America's veneer of cultural complacency evaporated. The year 1956 was the year Elvis released his first record, made his first television appearance, and started his movie caree...read more


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Nominee for Best Martial Arts
Check your ego at the door and open your mind to learn martial arts in a truely traditional Japanese manner.
Vote: BEST Martial Arts
The 2014 A-List awards are based on more than 92,000 votes from local Milwaukee-area experts.
Best Family Law ⋅ Best Wedding Caterer ⋅ Best Festival ⋅ Best Roofing ⋅ Best Window Cleaning


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On the Healthbeat, Doctor Barry Ramo tells us how to stay fit during Middle Age.
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On 18/07/07, Thomas Falkenberg <firstname.lastname@example.com> wrote:[color=blue]
> I can see the traps on the Linux client with tcpdump, but the
> snmptrapd-Daemon doesn't log it.[/color]
Is the 'snmptrapd' daemon receiving the notifications?
Try running it using the flag '-d', and see whether it displays
a raw packet dump of the incoming requests.
> I use NET-SNMP Version 5.1.2 .[/color]
Then you shouldn't have a problem with access control.
(More recent versions of the trapd require explicit authorisation
of acceptable community strings before displaying traps.
But this ancient version does not).
I'd be suspicious about firewall filtering (e.g. iptables) on the
receiving system - particularly if "snmptrapd -d ..." doesn't
show any incoming packets.
This SF.net email is sponsored by DB2 Express
Download DB2 Express C - the FREE version of DB2 express and take
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• The effects of behavior therapy with and without either pharmacotherapy or couples training were studied in 124 obese adults. In a 16-week behavioral weight-reduction program, patients were assigned to medication (fenfluramine hydrochloride) and no-medication conditions and to three spouse conditions in a 2 × 3 design. Two conditions consisted of patients with "cooperative" spouses; in one, patients were treated with their spouses, and in the other they were treated alone. In the third, patients with "uncooperative" spouses were treated alone. Fenfluramine produced significantly greater weight losses than no medication, but patients in the medication group regained weight much more rapidly during a 12-month maintenance period. The spouse conditions did not differ in weight change during treatment or follow-up. Obese spouses lost as much weight as the patients and were slightly more successful than the patients at maintaining their losses. Patients with obese spouses lost more weight than patients with nonobese spouses. Depression decreased in proportion to decreases in weight.
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text: Ahh... many are the memories of returning to work on Monday morning and finding that Mike spent the weekend cranking out some barely operational system which the customer already has it in production.... Mike's greatest strength is his ability to rapidly produce workable solutions to customer's problems. It's also his greatest weakness. -Eric -=--=---=----=----=---=--=-=--=---=----=---=--=-=- Eric B. Wolf 720-334-7734 On Thu, Jun 13, 2013 at 6:02 PM, Mike Harrison <cluon at geeklabs.com> wrote: > On Thu, 13 Jun 2013, Dan Lyke wrote: > > A "I have to convince my boss to write less code" thread on an IRC >> channel has devolved into discussing how to tie php-mode.el activity >> and "git commit" hooks to trigger playing sound files that'd agitate >> said boss's dog... >> > > I've been the subject of a few of those discussions.. Sigh. > > > > ______________________________**_________________ > Chugalug mailing list > Chugalug at chugalug.org > http://chugalug.org/cgi-bin/**mailman/listinfo/chugalug<http://chugalug.org/cgi-bin/mailman/listinfo/chugalug> > -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://chugalug.org/pipermail/chugalug/attachments/20130613/a4f2eee7/attachment.html>


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Jed the dog, Bart the bear, Ethan Hawke, Klaus Maria Brandauer
Boy meets wolf. Boy loses wolf. Boy gets wolf and sics him on villains. We're out of here.
In other words, if you think this movie follows in the admirable tradition of its Disney live-action animal-story predecessors, you're howling up the right tree.
Adapted from a Jack London novel, the film follows the converging fates of Hawke (Dead Poets Society), who arrives in 1890s Alaska looking for his father's gold claim, and of the part-wolf, part-dog White Fang, whose mother dies when he is a cub, leaving him in the wilderness. Brandauer is a prospector who helps Hawke. Jed, an Alaskan malamute-wolf mix, plays the grown-up White Fang, and Bart is a heavy's heavy—a 1,250-lb. grizzly who attacks Hawke.
The screenplay by Jeanne (The Journey of Natty Gann) Rosenberg, Nick (Fire Birds) Thiel and David (Streetwise) Fallon is on the slight side. "All he needs is a little bit of kindness," Hawke says of the pretamed White Fang. The point, though, is the relationship between Hawke and WF. The low-key Brandauer provides a pleasant foil.
Director Randal (Big Top Pee-wee) Kleiser mostly lets animal handler Clint Rowe make White Fang look like a canine for all seasons while cinematographer Tony (Mr. and Mrs. Bridge) Pierce-Roberts sweeps his cameras across the panoramic Alaska locations.
It's all too pat for adults, but they'll enjoy knowing this is a film their children can safely see. It's a movie where even vile bad guys don't get much more than a bonk on the noggin, where loyalty and determination are rewarded, where young hearts and spirits can be safely warmed. (PG)
Picks and Pans Review: White Fang
updated 01/28/1991 AT 01:00 AM EST
•originally published 01/28/1991 AT 01:00 AM EST


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Determining how much to spend on an engagement ring can be a hard thing. This is especially true due to there being many different engagement ring buying rules out there.
The most known engagement ring budget rule is probably the three month rule. This is where the engagement ring buyer determines how much to spend on an engagement ring based on what they make over a three month period.
So, if a person makes around $3,000 a month, that would mean that the engagement ring "should" cost around $9,000 according to the three month ring buying rule.
That is a ton of money for someone to spend on an engagement ring, especially when that's just a total income of around $36,000 a year!
I am going to say OUT with this old ring buying rule.
Spending 25% of your annual income on an engagement ring just seems crazy.
Insane even.
I know I'll probably get some flack for saying that, but I think busting your budget for an engagement ring is usually not a good idea…
Here are my tips to help you determine how much to spend on an engagement ring: [Read more…]


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|Ref #:
| 3680649
Added: > 6 Months Ago
|Capital Park (in Pretoria Central)
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Exquisite property, private and quiet. Breathtaking view from this magnificent property high up in the mountain.Modern 4 bedr house, stunning bathrooms, brand new kitchen with granite tops. Entertain with your heart´s delight under lapa equiped with kitchen, guest toilet, guest suite and bathroom, built in braai and boma.This property offes unique options for a guest house, offices and/or active family. Bachelor´s flat with seperate entrance from the house. Pool, double garage, fire place - too much to mention.This property is close to Maraba Shopping Centre, Rave Shopping Centre,Orthopaedic Hospital, Noordvaal Shopping Centre, Sammy Marks Square, Credo Primary School, Cripple Care School, Prinshof School and Cerebral Palsied School.BE A KING IN YOUR OWN PARADISE -DO NOT MISS THE OPPORTUNITY TO VIEW THIS VALUABLE, WELL KEPT PROPERTY!!
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