text:
Don't let it get away!
Keep track of the stocks that matter to you.
Help yourself with the Fool's FREE and easy new watchlist service today.
Just as markets breathed a sigh of relief over the Fed's reluctance to wind down its bond-buying program, taper talk has started up again. St. Louis Fed President James Bullard appeared earlier today on Bloomberg Television, calling the Fed's decision not to taper "borderline," and saying that data supporting a taper in October could very well occur. By late morning, the Dow Jones Industrial Average (DJINDICES: ^DJI ) and the S&P 500 were both in the red.
On the Dow, there are some surprise movers today, starting with some upside for a downtrodden JPMorgan Chase (NYSE: JPM ) .
Despite more news concerning the Securities and Exchange Commission's probing into the London Whale fiasco, JPMorgan is up more than 0.80% today. Even though the bank admitted to wrongdoing and paid a hefty fine, the bank is still being harangued by the SEC. The Wall Street Journal reports today that the agency is pursuing civil charges against individual employees at the bank. The only good news is that CEO Jamie Dimon is apparently not a focus of these inquiries.
At the other end of the spectrum is Caterpillar (NYSE: CAT ) , down more than 1.5% today after releasing some dismal retail equipment sales numbers. The 10% decrease in sales from one year ago follow sales declines in July and June, also compared to sales in the same months in 2012. The 30% drop in Asia-Pacific sales is the highest so far this year.
Also falling fast is Microsoft (NASDAQ: MSFT ) , so far the biggest loser with a drop of nearly 2.5% by late morning. After acknowledging that his short-sightedness failed to see that Apple's (NASDAQ: AAPL ) iPhone was leaving Microsoft in the dust, lame-duck CEO Steve Ballmer beseeched investors at yesterday's annual meeting to keep the faith and stand by the company. No doubt, all the brouhaha surrounding the opening day for sales of Apple's new iPhone 5S and 5C models isn't helping Mr. Softy this morning, as news outlets such as Bloomberg report long lines of consumers all over the world waiting for Apple stores to open.
The battle begins
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text:
Stephen Vincent Benet (1898-1943) was once the most popular writer of poetry and fiction in the United States, particularly from 1928 to his untimely death. When the Saturday Evening Post was the premier weekly in America, Benet was its premier writer. Benet was a viscerally emotive writer who wore his heart – and pen – on his sleeve. He achieved both critical esteem and popular acclaim. His 1937 classic, "The Devil and Daniel Webster", may be the most well known short story in American literature, in which the great lawyer and orator defends a farmer, Jabez Stone, who had sold his soul to the devil. In 1928 his epic long poem of the American Civil War, John Brown's Body, was a bestseller and took the Pulitzer …
Please log in to consult the article in its entirety. If you are a member (student of staff) of a subscribing institution (see List), you should be able to access the LE on campus directly (without the need to log in), and off-campus either via the institutional log in we offer, or via your institution's remote access facilities, or by creating a personal user account with your institutional email address. If you are not a member of a subscribing institution, you will need to purchase a personal subscription. For more information on how to subscribe as an individual user, please see under Individual Subcriptions.
Garrett Izzo, David. "Stephen Vincent Benet". The Literary Encyclopedia. First published 17 February 2005
[http://www.litencyc.com/php/speople.php?rec=true&UID=354, accessed 30 September 2016.]


text:
on June 13, 2013 - 12:01 AM
The proud new owners had been told that Grover Cleveland was a frequent guest at their property. I helped them find the building permit for their address – dated 1915. Grover Cleveland died in 1908.
In my own family, we learned of a half-sibling whose existence was secret for 50 years. It was a shock to discover that I was the fourth of four daughters instead of the third of three. We found our new sister and it has been a joy.
Not everyone is so fortunate. I know of genealogists being shunned by relatives after discovering inconvenient facts that toppled beloved family legends. For decades, the descendents of Thomas Jefferson indignantly rejected the story that he had fathered children with his slave Sally Hemings, until DNA evidence proved the Hemings descendents right.
Today, our city faces a similar conflict over history. The professional historians who compiled the new Historic Structures Report on the Michigan Street Baptist Church were unable to find any period evidence that the church served as a hiding place during Underground Railroad days, though it furthered the cause in many other ways. The report rightly documents and emphasizes the church's local and national significance, which dwarf this one claim.
I assisted with research for this report and my peer-reviewed article on the Underground Railroad in Buffalo is cited in it. Over 10 years ago, I started looking for eyewitness accounts confirming the church's story, which first appeared in print in 1936, 70-plus years after the fact. Wouldn't that be one of the greatest discoveries in Buffalo history? I also came up empty-handed.
Instead, I found a revealing counter-narrative. The Frederick Douglass Paper of Jan. 4, 1855, carried an extraordinary letter mentioning the Underground Railroad by name, signed by George Weir Jr., of Buffalo. Weir described eight "passengers" from Kentucky appearing at his doorstep at "an early hour." He "conducted them to a public house kept by one of our people." He and Phoenix Lansing then had a sleigh take them to the Black Rock Ferry, whereupon they were delivered to Canada.
We learn four important things from this letter:
1) George Weir, who was African-American, could read and write. Recent suggestions that oral legend is the only possible evidence of the church's history underestimate the level of literacy in this community. Buffalo's African-Americans first established literary societies in the 1830s.
2) George Weir felt safe advertising his and Lansing's names and efforts.
3) George Weir took his guests to highly public places, making no effort to conceal them.
4) Most importantly, George Weir's father was Pastor George Weir Sr., of the Vine Street AME Church. Why didn't Weir use his father's church? I believe that it was simply because the church lacked what his guests needed: food, drink and, in the middle of a Buffalo winter: heat.
Nothing in Weir's letter disproves the Michigan Street Baptist Church's hiding place story, but it does challenge almost everything we think we know about the Underground Railroad in Buffalo. History sometimes behaves in unpredictable ways.


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THE Chamber of Mines is keeping a close watch on developments at Harmony Gold's troubled Kusasalethu mine, near Carletonville, fearing that contagious worker unrest there could spread throughout the industry if not nipped in the bud.
The industry, which returns to work on Monday, is on tenterhooks, not knowing whether the wildcat strikes that plagued gold and platinum mines last year will continue into this year. Last week, National Union of Mineworkers (NUM) general secretary Frans Baleni was already picking up rumours of further strikes in the offing by workers who felt their wage expectations had not been met.
Members of the Chamber of Mines will meet early this week to share information and decide on a way forward, the chamber's senior executive for employment relations, Elize Strydom, said on Friday. A meeting with unions might be considered to establish a modus operandi, especially in the light of coming wage negotiations.
A repetition of last year's disturbances, which shaved 0.5 percentage points off South Africa's projected growth in gross domestic product, knocked export earnings and caused severe jitters among foreign investors, would be very harmful for the country.
Another reason for likely turbulence in relations in the mining sector this year is the fact that the two-year wage agreement for gold and coal mines comes up for negotiation in June. This is likely to fuel the bitter inter-union rivalry between the NUM and the relatively new Association of Mineworkers and Construction Union (Amcu), which was a feature of last year's Marikana tragedy, in which 46 miners died.
Amcu has made strong membership gains and has undermined the long-held NUM monopoly over the industry's workers and there are concerns the turf war between the unions will continue to destabilise production this year. Labour expert Andrew Levy said there was no doubt this would be a "difficult, troubled" year for the mining industry.
A London-based emerging markets economist at Nomura International, Peter Attard Montalto, agreed. "We see quite a high chance of further unrest, given our view that the issues during 2012 were structural rather than one-off. We think the underlying tensions between Amcu and NUM will remain and both will be pushing strongly for higher wage settlements, particularly after Amcu's success on this front in 2012 versus NUM's relative failure.
"The possible likely scenarios include NUM going aggressive and possibly violent to begin with, or else — more likely still — we see NUM attempt a 'normal' wage round, workers are dissatisfied, and Amcu and others whip up a second, violent wage round once again. Overall, the lesson of 2012 was that violence does beget further large wage increases as well as return-to-work bonuses to cover the cost of time striking — a very bad incentive for 2013."
However, Cadiz Corporate Solutions mining analyst Peter Major believed post-Mangaung labour conflict will be more contained and less chaotic than last year and would be more firmly managed by the government and the unions now that leadership positions in both had been consolidated. Amcu was definitely a "wild card", however, and was likely to be a source of instability in the sector.
Ms Strydom said the chamber was waiting to hear from Harmony today about developments at Kusasalethu. She stressed that something would have to be done to address union rivalry, "as we cannot have this level of violence, intimidation, total disregard for the law and collective agreements, and lack of respect for property and the safety of co-workers. It cannot be tolerated and we will need to do what has to be done."
Harmony Gold, South Africa's third-largest gold producer, decided to delay the post-festive-season reopening of Kusasalethu mine last week despite the daily loss of production amounting to millions of rand. Spokeswoman Marian van der Walt said this was so that Harmony could "review its financial and operational status" after the strikes last month and devise a strategy to deal with the inter-union conflict.
The first priority, she said, was to ensure the safety of employees, something that could not be guaranteed at that stage. Ms van der Walt expected clarity on the situation this week.
Kusasalethu has been plagued by violent clashes between the NUM and Amcu, which has applied for recognition by Harmony Gold. Ms van der Walt said a process of membership verification was under way. The mine's 5,000 workers were sent home a day earlier than expected on December 21 after an underground sit-in by 1,700 workers, who demanded the reinstatement of about 580 workers suspended because of their participation in an illegal strike on October 25.


text:
Victor Jeffrey Serote
posted this on October 27, 2010, 1:46 AM
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Posted at 1:41 PM on July 19, 2011
by Paul Tosto
(1 Comments)
The special session to pass all the bills needed to end the shutdown starts at 3 p.m. But as we await the official end to the 19 day shutdown, this special session will not end the drama that is the Minnesota Vikings stadium debate.
Public financing for a Vikings stadium is not on the agenda for the special session.
Gov. Mark Dayton told reporters he's not sure if he'll call a special session later in the year.
The Vikings, meanwhile, haven't said anything official and told reporters briefly that the team was assessing its options.
It's no surprise that the stadium isn't in this special session plan.
GOP House Speaker Kurt Zellers, Senate DFL leader Tom Bakk and Gov. Mark Dayton all said at some point in the past week that the subject of a Vikings football stadium bill hadn't surfaced for weeks and made it clear that it was unlikely to come up during a special session meant to finalize a budget and end the state shutdown.
Expect the "Vikings leaving" rhetoric to heat up, of course. But I'd also pay attention to the comments Senate DFL Leader Tom Bakk offered Friday on MPR's Midmorning program. He said then he didn't expect the stadium to come up in the shutdown session.
But then he added:
I"m going to suggest to the governor that he put together a task force to work on the stadium proposal and that some time next fall -- because the lease expires in December -- we see if we can find an agreement that we can find bipartisan support for and try to have a special session maybe sometime in the fall on that subject.Politically, that's not a bad path. Will it work for the Vikings? Stay tuned.Click on the play button below to listen to Bakk's comments on the Vikings, starting at the 37:15 mark.
go vikes


text: The Relativistic Heavy Ion Collider at Brookhaven is colliding fully ionized gold (Au) nuclei accelerated to an energy of 200 GeV per nucleon. Each Au nucleus contains 197 nucleons. (a). What is the speed of each Au nucleus just before collision? (b) What is the momentum of each at that instant? (c) What energy and momentum would be measured for one of the Au nuclei by an observer in the rest system of the other Au nucleus?


text:
I will follow as many websites as I can. Feel free to add me as a friend on Facebook, but let me know in a message that you are a fellow blogger. http://www.facebook.com/dfgcdg521.
I'm looking for new blogs to follow as well as new followers for my own site :) www.ambermaybe.com
Gorgeous blog! I love it :)
Victoria Stiehl said:
Hi I have a new blog and would love some followers, or any advice or tips. Xx


text:
On 2008-07-14, Rockinghorse Winner <firstname.lastname@example.com> wrote:[color=blue]
> There are really two classes of computer users, those who know what they're
> doing (for the most part), and those that don't (for the most part). The
> one needs the CLI if they're going to make full use of the OS and speed work
> and maintenance. The other have a limited number of demands, that can be
> counted on one hand -- mainly internet applications, multimedia, printing.
> There is liable to be very little maintenance performed manually, other than
> what is built into the system.
> For this reason, I believe Linux is the better OS for Mom & Dad, not to
> mention grandpa and grandma, because the whole circle of hell know as
> malware is entirely sidestepped. Their computers will not slow to a halt every
> 3 weeks from spyware nececitating the kid to come over and *fix Dad's
> computer.*
> If you're going to give a computer to your folks, you'd have to be cruel to
> give them a Windows machine, IMO.[/color]
I would whole-heartedly agree.
When giving a system to someone of limited knowledge, it just makes
sense to give them a machine with everything installed that they need,
and not giving them access to any admin functions. Install ssh
(securely) and open a firewall port so that you can log in remotely if
they need some minor problem fixed, or if they need an additional app
They can get their e-mail, use the web, write their documents and
print them, and so on. What they WON'T get is the viruses and
spyware. They won't have to fear web sites that might be considered
"dangerous". They won't have to be afraid of opening e-mails. They
won't be able to install that great screensaver-virus that their
friend gave them.
Be kind to your parents, give them Linux...
Joe - Linux User #449481/Ubuntu User #19733
joe at hits - buffalo dot com
"Hate is baggage, life is too short to go around pissed off all the
time..." - Danny, American History X


text:
Think back to your time at Bradley. Your best friends were probably people that had common interests. That's why the BUAA created the affinity groups program. Affinity groups unite alumni who share a common bond or experience.
There are currently six affinity groups:
If you would like more information about joining or starting a new affinity group contact Alumni Relations at firstname.lastname@example.com or complete our Affinity Group Form.
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text:
I like it....
New Videos
Subscribe to the Sneaker News Youtube Channel
February 8, 2012 BY Brendan Dunne / 10
The great equalizer that is eBay has proven time and time again that even the most exclusive of sneakers will be up for grabs at some point or another. We recently showed off the Air Jordan IV from the History of Flight series that was up for grabs, with the surrounding excitement being dimmed a bit by the fact that a somewhat similar Air Jordan IV found its way to retail already in the form of the all-white 'Silver Anniversary' edition a few years back. Such is not the case with the Air Jordan VII 'History of Flight', as this particular model never made it into the Silver Anniversary collection, making the pure white uppers that much more sought after. Of course there's also the premium woven lining, or the fact that you could probably count off the number of these that are out there in the wild on your two hands. Whichever way you slice it, it's quite a treat to have a shot at owning the Air Jordan VII 'History of Flight' so peep the pics as well as the auction from btn_16 on eBay.
Filed under: Air Jordan eBay Sample
Tags: Air Jordan VII
I like it....
why coudnt they make Bordeauxs with this quality ? -.- Still love my pair but damn
@ Homie your right about that.. they are dope... But I would keep as one of the ds's
Good shoe to keep dead.......thats it. Nothing special
One of my favorite pairs from the collection. This colorway doesn't fit most of the shoes but it looks nice on the 7's
I'm guessing this guy has all of them at this point. He must have some really good connections. Kinda pricey though, not for everyone.
I dont care how rare they are i dont like any of this series (history of flight) too damn plain
Im so jelly
GrAiLz.. ~*FrEe LiL WiLLiE*~
Subscribe to the Sneaker News Youtube Channel


text:
Wherever you think the edge of the world is. We are four hours past that point.
The idea of Taktse International School was conceived in the winter of 2004 when a group of concerned Sikkimese gathered to discuss the problems confronting our society: the erosion of traditional values, the increasing number of alienated youth with little or no marketable skills, the growth of mass consumerism, the growing disparity in wealth, the degradation of environmental resources, and the impoverishment of ethical standards in public offices. Rapid development and the failure of the greater society to wisely manage the inevitable forces of change have exacerbated these problems over the years.
These challenges are particularly common in developing countries that are experiencing rapid modernization. Therefore, we wanted to create model school and community capable of producing the compassionate and ethical leaders that developing societies so desperately need.
We have built an amazing school and community in just seven years, but we need help. Our Taktse students, primarily from the hills (Indian's North East), face the larger Indian stigma of being bad at science and math. Of course this isn't true, but there is an aspect of self-fulfilling prophesy (and stereotype bias) at play.
We want students who love reading, math, science and life to come and help us design curriculum, help us make hands-on science joyful. MIT students will learn valuable cross-cultural skills, be immersed in a joyful learning community and be able to give back in a very substantive way. There are qualities that MIT students have, that our children will learn through osmosis.
We ask for a nominal fee of $100 per week to cover room and board. Sponsorships or scholarships may be available on a case by case basis.
We are looking for students who can aid us in:
1. Design and implement curriculum for teaching computer programming languages as the second language (like French or Hindi in other schools) starting from first or second grade (why wait for high school or college?)
2. Design and implement a hands-on science museum integrated with the school (something like the Children's Discovery Museum in Acton), along with a mobile component (where our children can take the hands on science into the villages)
3. Implement the Elementary Engineering Curriculum developed by the Museum of Science
4. Design and implement a medical curriculum for elementary school (not unlike the Museum of Science curriculum, but focused on health monitoring, prevention and first aid)
5. Implement Khan Academy's "flipped classrooms" in our school.
6. Help us start a culture of Origami in Sikkim, first at the school and then in the larger community
7. Propose how you could best help us!
The projects need English, humility and a strong work ethic.
We invite students from MIT at all times of year.
Sherry Dickstein, MD
US-based Resource Fellow Coordinator
MIT students who develop projects around these ideas may apply for support from the Priscilla King Gray Public Service Center's Fellowships and Internships programs. Please check the program descriptions and deadlines and talk to program staff to determine which is most appropriate for your needs and project.
If you want to volunteer or you have funding from outside the PKG Center that enables you to work on this project, that's great! However, please do let us know if you work on a project you saw advertised here, even if you don't use our funds. And remember, the PKG Center staff are happy to advise on service projects even if we are not funding them ourselves.


text:
From the Division of Skull Base Surgery (Drs Jarrahy and Shahinian) and Department of Surgery (Dr Berci), Cedars-Sinai Medical Center, Los Angeles, Calif; and Department of Surgery, New York University Medical Center, New York (Dr Jarrahy).
To obtain objective evidence that the use of endoscopy in the surgical management of pituitary tumors improves intraoperative visualization and significantly impacts operative outcomes.
Case series of pituitary adenomas treated surgically by endoscope-assisted microscopic resection.
University-affiliated tertiary care medical center.
Consecutive sample of 9 patients referred for surgical management of pituitary adenoma.
Each patient underwent transseptal transsphenoidal microscopic tumor resection. The procedure was modified by the use of intrasellar endoscopy as an adjunctive imaging modality. Following complete microscopic resection of tumor, rigid 0° and 30° 4.0-mm endoscopes were used to conduct a final survey of the sellar and parasellar spaces. Residual tumor fragments identified during this endoscopic examination were removed.
Outcome Measures
Endoscopes were thought to have a significant impact on surgical therapy in cases where residual tumor that was not detected microscopically was identified and removed during endoscopic examination. Analysis of each case included correlation between intraoperative findings and retrospective review of dictated operative reports and intraoperative videotape.
Three of the patients with macroadenoma (33% of total, 43% of macroadenoma cases) had tumor fragments that were only identified and removed endoscopically.
Endoscopy provides distinct advantages over microscopy in imaging intrasellar and parasellar structures during pituitary tumor resection. These data support the numerous anecdotal accounts of the usefulness of pituitary endoscopy and are consistent with the small amount of objective evidence offered on the subject.
THE EMPHASIS placed on minimally invasive surgery has guided the evolution of surgical practice over the past century in all surgical subspecialties. Progress in the field of pituitary surgery in particular exemplifies this. Harvey Cushing, widely credited as the innovative force behind many modern neurosurgical techniques, had extensive experience with both transcranial and transsphenoidal approaches to the pituitary gland over the first half of this century.1- 4 Based on these experiences, he ultimately concluded that the transcranial subfrontal approach, despite its invasive nature, was the procedure of choice for surgical management of pituitary tumors, especially those with suprasellar extension. His opinions were contested by his contemporaries, who argued that the less invasive transsphenoidal approach not only resulted in less morbidity but also that that the procedure was equally effective in providing access to suprasellar tumors.5- 8
This debate was not truly settled until the second half of the century. Following Hardy and Wisger's9 introduction of fluoroscopy and microscopy to the operating room, the transsphenoidal technique emerged as the first choice in surgical therapy of the vast majority of pituitary tumors.10- 15 With the operating microscope and intraoperative fluoroscopy available, the surgical field could be magnified and radiographically defined. These capabilities definitively answered Cushing's original lamentations regarding the obscurity of the pituitary gland when viewed from a transsphenoidal perspective.
Advances in medical technology are once again playing a central role in the evolution of pituitary surgery. Recent experience in endoscopic sinus surgery and improvements in endoscopic instrumentation have provided the basis for the implementation of endoscopy in the resection of pituitary tumors. Experience with endoscope-assisted transseptal microscopic procedures has been reported.16- 22 The fully endoscopic transnasal transsphenoidal technique in the surgical management of pituitary tumors has been described by Jho et al,23 who present comprehensive results inclusive of preoperative and postoperative hormonal status and complication rates associated with surgery.
Although the sizes of patient populations and duration of follow-up periods in these studies are generally limited, these contributions do facilitate comparison with outcomes of transsphenoidal surgery. Nevertheless, definitive objective evidence of the efficacy of pituitary endoscopy is currently lacking. With greater and more prolonged experience in clinical series of endoscopic pituitary surgery, more data will be generated, but supportive information must be available before a change in the standard method of performing pituitary surgery can be widely accepted.
With this in mind, we studied a series of 9 patients who received endoscope-assisted microscopic resection of pituitary tumors via a sublabial transseptal approach. In our analysis, we have attempted to objectively define the benefits of endoscopy in pituitary surgery.
The following procedure was performed on 9 patients referred for surgical management of their pituitary tumors. Fully informed consent, including detailed explanations of the use of adjunctive endoscopy, was obtained from each patient by the senior surgeon (H.K.S.). The surgical protocol was reviewed and approved by our local institutional review board.
The approach to the pituitary gland closely resembles the transseptal transsphenoidal technique originally described by Cushing.4
Once the gland is exposed, microscopic resection of tumor proceeds until all identifiable parts of the lesion are removed. Following this, a 0° 4.0-mm endoscope (Karl Storz of America, Culver City, Calif) is advanced to the sella and used to conduct a survey of the surgical field. Any tumor fragments not originally identified using the microscope are removed under direct endoscopic visualization. Next, a 30° endoscope is introduced and used to provide additional exposure of the suprasellar and parasellar areas. Any residual tumor therein is also endoscopically removed.
Closure is obtained with reconstruction of the floor of the sella and placement of an abdominal fat graft into the space of the sphenoid sinus.
Operative summaries and videotape were retrospectively analyzed. Comment on the efficacy of endoscopy in finding residual tumor was sought in the former and correlated with visual evidence in the latter.
Among the 9 patients, 3 were male (33%) and 6 were female (67%). Average age of the patient population was 41.9 years. Presenting symptoms included headache, visual disturbances, and physical manifestations of various endocrinopathies. Diagnostic magnetic resonance imaging revealed microadenoma in 2 patients; all others had a preoperative diagnosis of macroadenoma. There were no complications related to surgery, including stroke, neurological deficit, permanent diabetes insipidus, or cerebrospinal fluid fistula. Table 1 presents the baseline clinical data of the patients.
In the 2 cases of microadenoma, resection was guided by gross identification of the normal pituitary gland and exploration of the intrasellar quadrant where tumor was identified on preoperative magnetic resonance images.
The 0° endoscope provided excellent visualization of the pituitary gland in its native position. By maneuvering the endoscope within the sella, a greater area was viewed compared with the static anteroposterior perspective under the microscope. When the 30° endoscope was used, structures in the suprasellar and parasellar spaces came clearly into view, including the medial walls of the cavernous sinuses and the optic chiasm.
Endoscopic survey revealed residual tumor in 3 patients with macroadenoma. This represents 33% of the total sample and 43% of macroadenoma cases. In all of these instances, tumor was abutting the medial walls of the cavernous sinuses, hidden from microscopic view (Figure 1). The tumor remnants were successfully removed under endoscopic visualization, resulting in complete gross tumor resection.
Endoscopic image of the parasellar recess viewed with 30° rigid endoscope. Dural retraction reveals residual tumor (black arrow) against the medial wall of the cavernous sinus. This tumor was not visualized microscopically. The suprasellar space is also appreciated (white arrow).
The use of endoscopy in the resection of pituitary adenomas, used to varying degrees by different authors, has been well described in recent years.16- 20,22 Some have described their experience with endoscopy as the sole imaging modality for the entire procedure.21,23- 26 Despite these numerous published reports, however, overall experience with fully endoscopic transnasal pituitary surgery remains limited. More widespread experience with this technique is required before it gains acceptance as an equivalent or preferable alternative to transseptal transsphenoidal microscopic surgery in the management of pituitary adenomas.
In general, before such a shift in surgical practice can occur, several fundamental considerations must be made. First, there should be some objective evidence that the proposed technique represents an improvement over the old method. Second, the proposed innovation should involve no undue burden or risk to the patient. Third, there must be a means by which a new surgical technique can be reasonably approximated in a controlled setting for training purposes.
In the case of fully endoscopic pituitary surgery, the second and third criteria have been met,18,24,27- 29 but the first has yet to be satisfied. Surprisingly, the few published reports describing experience with fully endoscopic resection of pituitary adenomas have been preceded by a paucity of objective data in support of the merits of this technique. Some authors have criticized endoscopic equipment as being cumbersome and the endoscopic perspective as being limited in this setting.20,21 Before sweeping changes in the standard of pituitary surgical practice are proposed or accepted, more impartial information should be available.
Spencer et al30 have contributed to the limited body of evidence that exists on this subject by quantifying and comparing the "volumes of view" of the endoscope and microscope in the setting of pituitary surgery. In their anatomical study of surgical approaches to the pituitary gland, they were able to objectively demonstrate with statistical significance that the 0° endoscope afforded more comprehensive views of the sella turcica than the microscope.
Even more compelling evidence is provided by Helal.17 In 15 (41%) of the 37 patients in his series, residual tumor fragments were discovered and successfully resected during endoscopic surveys of the sella turcica. These surveys were conducted only after tumor resection under microscopic exposure was thought to be complete, thereby highlighting the differences between the optical capabilities of the endoscope and the microscope.
In our series, we demonstrate a 33% detection of residual tumor not originally visualized under the microscope. When our analysis is restricted to only patients with macroadenomas, this rate increases to 43%. Naturally, the limited size of our patient population prevents these data from possessing a significant degree of statistical power. Considering the dearth of objective data in support of replacing the microscope with the endoscope in pituitary surgery, however, even these observations do provide evidence that endoscopic imaging of the intrasellar, parasellar, and suprasellar spaces is more comprehensive than that provided by the operative microscope. We can preliminarily conclude that the potential impact on the efficacy of tumor resection and subsequent rates of tumor recurrence is significant when endoscopy is implemented as an imaging modality in the surgical management of pituitary tumors. Experience with greater numbers of patients in multiple centers is necessary before definitive conclusions can be drawn on this subject and before a new standard in the surgical therapy for pituitary adenomas is set.
Accepted for publication March 23, 2000.
Corresponding author: Hrayr K. Shahinian, MD, Division of Skull Base Surgery, Cedars-Sinai Medical Center, 8653 W Third St, Suite 490W, Los Angeles, CA 90048 (e-mail: email@example.com).
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There will be 2 "Anything Goes" Challenges per month for you to try, each challenge will run for two weeks!
During these Birthday Challenges...we may throw in a " Toppings" Option! This will be an Option for both the Design Team and our participants. You still have a chance to win even if you don't use a topping!
We will announce a winner every 2nd week!
Any product is welcome and you are welcome to create a birthday card, invitations, tags, gift bags or anything else you may need for an upcoming birthday!
Challenge Rules (to keep things fair):
1. You must make something with a BIRTHDAY theme.
2. Please add a direct link to your blog or to an online gallery.
3. Feel free to use other challenges or for a stamp release, it doesn't matter, as long as you add this challenge link to your post.
4. Any offensive posts or cards that do not follow the guidelines will be removed out of courtesy to fellow bloggers and the design team.
5. As always, please have fun and make the sketch your own!
This linky will close at Noon on the Tuesday before the next Seize the Birthday Challenge.


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Richard Chesher
Kuto Beach Ile Des Pins
Richard Chesher
Gadji anchorage Ile des Pins New Caledonia
Kyu-Yong Choi
Oro Bay ㅣ 오로 천연풀장
Richard Chesher
Peak Nga Iles Des Pins2
Kyu-Yong Choi
Fantastic Nokanhui Island in New Caledonia - 뉴칼레도니아 노깡위섬
Gregory Panayotou
Isle of Pines : Kaa Nuë Mera Bay
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How to Break In New Shoes
Folks, … I just don't know what to say besides thank you, and that I'm still the luckiest guy any of you know. The Basic Instructions Subscription Service has only existed for 48 hours (as of this writing) and we're well over 10% of the way to our goal of 800 subscribers.
Even more amazing has been the number of you who have just donated money. Sometimes it's easy to forget that there are real people out there who actually read this thing. Thank you all for reminding me in such a great way.
So anyway, thanks for the subscriptions, the donations and for using my Amazon Affiliate links (US, UK, and Canada) and please keep it up!
Reader Comments (29)
Wow, I must say, this is one of your most sophisticated ones, at least in the fourth panel. I love how, despite you being the target of laughs, you score over Missy and she doesn't even notice. It was an elegant win-win situation... or more like lose-lose?
I signed up for the subscription service, because I love the strip and it's a small easy way to give a little back. I normally read the strip via rss, but the email you sent was nicely formatted on my phone. I would suggest that you consider using a password protected blog with an RSS feed, though. It would provide a slightly higher bar toward prevent early redistribution of the content. I would also consider gifting a subscription if that were an option.
Love your comics love the point you're making here i will be donating
Scott, I have really enjoyed your comic strips and I have just subscribed.
I hope you get to the 800 subscribers soon, I'm sure you'll get more than that!
Really great stuff, original and very funny!
Bet you can't wait to give up that day job!
All the best,
Subscribed. You do great work; I hope you can keep at it, with our subscriptions! Thank you for "facilitating laughter"!
I subscribed to the strip on Monday. Congratulations Scott on getting so many subscribers! Also I think you guys might like this, which the first subscription strip reminded me of. http://www.youtube.com/watch?v=GeSMxA-E944
Signed up, it's well worth the $2.50 for these strips.
The human body is highly efficient and incredibly adaptable.
Your feet will mould to the shape of the shoe MUCH faster than the shoe will mould to your feet, depending on the construction of the shoe. Assuming your "ugly and uncomfortable" shoes are Office shoes (or Business shoes), this is particularly true.
Buy comfortable shoes first time round!
Any plans to expand to into the European market .. ?
So glad I subscribed, the first email I got put a smile on my face at the end of a long day. Worth it already!
Nice. I feel your pain, only when I'm truely comfortable wearing a pair of shoes, the time they fall apart isn't too far away.
Also, you are now the third form of entertainment on the internet I've ever paid for (Yargh!)
Thanks for bringing a smile to my face on a regular basis, I will donate but not subscribe 'cos I don't have much disposable income and my church leader needs a new Porsche so that he can help the starving in Africa all the quicker before they die, I hope you understand.
Hilarious comic, but I'm a podiatrist and I have to say this every day so I can't help saying now, that your shoes should not need to be broken in. If they're uncomfortable when you buy them they don't fit you correctly. How this applies to people I leave up to you.
I wasn't sure I liked the last line in panel 2 until I read the last line in panel 4. Well played sir, well played.
I second James Litton's suggestion, about an RSS feed.
I prefer RSS to email for stuff like comments and news, and I'd gladly pay for an ad-free RSS feed.
I guess there are more admin issues with RSS than with email. You could look at Ars Technica's premium RSS service for some ideas, they give their premium subscribers a custom RSS URL. There's always the danger that somebody will share the URL, but they monitor where content is going and block a URL if it seems that many PCs are being served by it.
Anyway, I think I will donate for now, but would gladly pay monthly for an ad-free RSS feed.
Scott, well played sir. I am like many others that unfortunately are not in position to subscribe- though I would, if I could. Funny thing is, I'm right on the cusp of it now, so if these kind people can carry the load for a few more months I'll gladly join their ranks and hold the line in short order.
Keep up the good work, people!
Great comic. Love the progress bar! It should be a header for the website until all is said and done!
Can you provide some details on sponsorship? Sounds interesting.
Note from Scott: Be happy to. Please just drop me an e-mail!
HA! Love the progress bar!
I commend you're approach; very Louis C.K.; Make a product that's worth while, find a way to get it to your audience in a way that makes sense. Also, like Louis' $5 'please don't steal this special' available for download in relatively unprotected format, I think your fan-base is a loyal one that would be unlikley to share a custom RSS URL, but as boz alluded to, protect yourself.
I'm not a subsciber yet, but I'll gladly donate to something that provides me this much enjoyment as a way of saying Thanks!
I vote no on proposition RSS feed, to the "will unsubscribe" level. Loved being the advanced comic directly in my email.
i like the idea of gift subscriptions. i hate buying giftcards (what if they're not redeemed? i didn't buy it for amazon.com's birthday!) and really, there's nothing else i know they'll like.
Note from Scott: In theory, all you'd have to do is subscribe and put their e-mail address in there in place of your own, then warn them it's coming. Heck, e-mail me and tell me to watch out for the order and I'll even send a little e-mail introducing myself.
Scott - I'd be happy to subscribe, and in fact tried to do so but backed out, if there was as way for me to do so without having to have/sign up for an active PayPal account. I'm STILL in dispute with PayPal over them reversing something that wasn't my fault from 4 1/2 years ago. I will absolutely never, ever deal with PayPal again if I can possibly avoid it. If you can offer something like Google Checkout/Wallet, Amazon Payments, something like that, I'll subscribe in a heartbeat. Heck, I'd set up an automated payment thingy via my credit union to send you a monthly check if something could be worked out.
Just a minor suggestion - would be awesome if we could purchase the $30/annual as an option over /month. I have a strong suspicion that in 6 or 7 months the regular payment to Missy will be a "WTF?" from our Household CFO and I, being a short-sighted creature, will have no idea. Of course that would require a reminder email setup for 12 months... so might be extra work... Hmmm....
If we subscribe, can we get high-res versions of the old comics, too? I have several that I use as cover slides on powerpoint lectures, and having a slightly less-fuzzy version at that scale would be great.
Note from Scott: What comics do you use? I'd be happy to send high rez copies with or without a subscription.
I donated but didn't subscribe, because I prefer to read comics/blog posts in rss rather than my inbox. I would potentially be interested in a private RSS feed for a fee.
Also, in ~one year you should put out a new notice about donations. I treated my donation as a subscription, and will do it again in a year's time, if I remember. I'm probably not the only one who wanted to "subscribe" but who didn't want more email.
So excited about the subscription service! I have felt guilty for reading your comics online and through my iPhone for years without paying, so I'm thrilled to support you. Can't wait to get some BI books for Christmas gifts this year!
Oh, and wait till/if you have kids. Buying shoes takes on 4 more levels of frustration because kids go from "these shoes feel awesome" to "these shoes are stabbing my feet from across the room" in the same day.
Just subscribed, as you are one of my very favorite comics on the web (and arguably the funniest)! Can't wait to start getting the emails!
I've gotten caught in the "break them in" trap too many times. Now if it's not comfortable in the store, then I don't bother. (Haven't quite figured out what to do when they're comfortable in the store and then pinch my feet the first time I put them on at home though)