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There are 142 companies tagged `tech`; raised $1.8B from 384 investors
Abound Solar raised $510M from Invus, Bohemian Companies, BP Alternative Energy, DCM, and U.S. Department of Energy in 2 rounds.
Videology raised $134.2M from Catalyst Investors, New Enterprise Associates, Valhalla Partners, Comcast Ventures, Pinnacle Ventures, New Enterprise Associates, Comcast Ventures, New Enterprise Associates, and Valhalla Partners in 5 rounds.
Virident Systems raised $129.7M from Seagate, Mitsui Global Investment, Globespan Capital Partners, Sequoia Capital, Artiman Ventures, Artiman Ventures, Globespan Capital Partners, Hercules Technology Growth Capital, Mitsui Global Investment, Sequoia Capital, Globespan Capital Partners, Globespan Capital Partners, Intel Capital, Sequoia Capital, Artiman Ventures, Cisco, Artiman Ventures, and Spansion in 7 rounds.
Ice Energy raised $92M from Energy Capital Partners, Good Energies, Sail Capital Partners, Second Avenue Partners, Energy Capital Partners, Second Avenue Partners, Goldman Sachs, Good Energies, and Second Avenue Partners in 4 rounds.
SolarEdge raised $85M from Norwest Venture Partners, Opus Capital, Walden International, Genesis Partners, Vertex Venture Capital, Lightspeed Venture Partners, Lightspeed Venture Partners, Opus Capital, Genesis Partners, Walden International, ORR Partners, Vertex Venture Capital, JP Asia Capital Partners, Vertex Venture Capital, Opus Capital, Genesis Partners, ORR Partners, Walden International, and GE Capital in 3 rounds.
HouseTrip raised $59.7M from Accel Partners, Index Ventures, Balderton Capital, Balderton Capital, Index Ventures, and Index Ventures in 3 rounds.
AvantCredit raised $59M from August Capital, Victory Park Capital, QED Investors, August Capital, Victory Park Capital, and Victory Park Capital in 3 rounds.
iYogi raised $57.6M from Sequoia Capital, Canaan Partners, SVB Capital, SAP Ventures, Draper Fisher Jurvetson (DFJ), Draper Fisher Jurvetson (DFJ), Canaan Partners, SAP Ventures, SVB India Capital Partners, SAP Ventures, SVB Financial Group, Canaan Partners, Canaan Partners, and SVB India Capital Partners in 4 rounds.
Lehigh Technologies raised $55.5M from Leaf Clean Energy, Kleiner Perkins Caufield & Byers, Index Ventures, NGP Energy Technology Partners, Index Ventures, and Kleiner Perkins Caufield & Byers in 3 rounds.
Brammo raised $53.5M from Polaris Industries, Polaris Industries, Alpine Energy, and NorthPort Investments in 3 rounds.
DoubleVerify raised $46.5M from JMI Equity, Institutional Venture Partners, Blumberg Capital, First Round Capital, Institutional Venture Partners, Blumberg Capital, First Round Capital, and Genacast Ventures in 3 rounds.
Pie Digital raised $44.3M from T-Venture, Foundry Group Pty Ltd, Individual Investors, T-Venture, T-Venture, Foundry Group, Individual Investors, Foundry Group Pty Ltd, Individual Investors, and T-Venture in 6 rounds.
Bestofmedia Group raised $38.9M from Avenir Entreprises Gestion and Index Ventures in 2 rounds.
SecondMarket raised $34.2M from The Social+Capital Partnership, Li Ka-shing, Temasek, and FirstMark Capital in 4 rounds.
Travora Networks raised $30.5M from Village Ventures and Rho Capital Partners in 3 rounds.
Viridity Energy raised $29M from Mitsui & Co, Intel Capital, and Braemar Energy Ventures in 2 rounds.
Medialets raised $28.4M from Greenspring Associates, Foundry Group, 500 Startups, DFJ Gotham Ventures, DFJ Gotham Ventures, Bobby Yazdani, and Foundry Group in 4 rounds.
NetShelter - Data Powered Media raised $26.1M from Rho Capital Partners, Rho Canada, Relay Ventures, GrowthWorks Capital, Rho Canada, and Relay Ventures in 2 rounds.
BandPage raised $18.3M from GGV Capital, Northgate Capital, Mohr Davidow Ventures, and Mohr Davidow Ventures in 2 rounds.
TuneUp raised $15.6M from IDG Ventures, KPG Ventures, IDG Ventures, KPG Ventures, and KPG Ventures in 4 rounds.
Recurve raised $14M from RockPort Capital Partners and Shasta Ventures in 2 rounds.
IdeaPaint raised $13.3M from Breakaway Ventures, Fireman Capital Partners, and Breakaway Ventures in 3 rounds.
nlyte Software raised $12M from NGEN Partners, Balderton Capital, and Ruffer .
Retrevo raised $11.9M from Alloy Ventures, Norwest Venture Partners, Alloy Ventures, Norwest Venture Partners, and Alloy Ventures in 3 rounds.
Work4 raised $11M from Matrix Partners .
InvestLab raised $10M from VantagePoint Capital Partners and Citi Ventures .
Wrightspeed raised $10M in 2 rounds.
Prism Skylabs raised $10M from Triangle Peak Partners, Pacific Partners, Andreessen Horowitz, IDG Ventures, Anthem Venture Partners, MkII Ventures, SeriesG, Data Collective, Promus Ventures, CrunchFund, Yuri Milner, Aaron Patzer, Brad Garlinghouse, David Ulevitch, SV Angel, TomorrowVentures, Garrett Camp, and Founder Collective in 2 rounds.
Rally.org raised $7.9M from Relay Ventures, FLOODGATE, Greylock Partners, Google Ventures, Collaborative Fund, Michael Birch, Eric Ries, Josh Spear, Scott Belsky, Naval Ravikant, Transmedia Capital, Ariel Poler, Habib Haddad, Farallon Capital Management, Ephraim Luft, Ross Garber, Aaron Dignan, Seth Berman, Tom Brown, Vianovo Ventures, and Mark Kingdon .
Misfit Wearables raised $7.8M in 2 rounds.
AdMobius raised $7M from Opus Capital and Storm Ventures .
Bowman Power raised $6.7M from Octopus .
CodaMation raised $6.5M from Grupo Roggio .
Playdek raised $6.2M from IDG Ventures, ff Venture Capital, Deep Fork Capital, Greycroft Partners, Jarl Mohn, Qualcomm Ventures, Rho West, Greycroft Partners, Deep Fork Capital, Jarl Mohn, Richard Wolpert, Jeff Solomon, Kevin Donahue, Deep Fork Capital, Jarl Mohn, Paul Bricault, Charles Yim, Josh Resnick, and Yoshi Maruyama in 4 rounds.
Solar Power Technologies raised $6.1M from Austin Ventures and Oxantium Ventures .
Genesis Media raised $6M from SamStella and Ocean Group in 2 rounds.
Metabolix raised $6M from U.S. Department of Energy and U.S. Department of Agriculture .
UrbanBound raised $6M from Grotech Ventures and StarVest Partners in 2 rounds.
LUMOback raised $5M from Madrona Venture Group and Innovation Endeavors .
StitcherAds raised $4.3M from Ulster Bank Diageo Venture Fund, Delta Partners, Delta Partners, and Enterprise Ireland in 2 rounds.
That's Solar raised $4.2M .
Closely raised $4.1M in 2 rounds.
Club W raised $3.6M from Crosscut Ventures, 500 Startups, Guild Capital, and Siemer Ventures in 2 rounds.
LightSail Education raised $3.5M from Viceroy Ventures and Gotham Capital .
Introhive raised $3.3M from GrowthWorks Atlantic Venture Fund and New Brunswick Innovation Foundation in 2 rounds.
Hireology raised $2.7M from FireStarter Fund in 3 rounds.
Tech Cocktail raised $2.5M from Tony Hsieh .
NewsCrafted raised $2.4M from Broadmark Capital in 2 rounds.
Planet Metrics raised $2.3M from Angel Investors LP and Draper Fisher Jurvetson (DFJ) .
Murfie raised $2.3M from DaneVest Tech Fund Advisors and Barry Silbert in 2 rounds.
NetCom raised $2.3M from Confrapar .
Tricycle raised $2.2M from SunTrust Bank, The Southern Appalachian Fund, and Northwest Georgia Bank in 4 rounds.
Newtopia raised $2.1M from Angel Syndicate and BDC Venture Capital in 2 rounds.
ReformTech Sweden AB raised $2M from BioArt AB .
KloudNation raised $2M from Ian Bonner, Catapult Partners, and Globe Capital LLC .
Stackify raised $2M from Watson Technology Group .
Zesty raised $2M from TA Venture and ABRT Venture Fund .
WHILL raised $1.9M from Itochu Technology Ventures, 500 Startups, SunBridge Global Ventures, Eric Kwan, VegasTechFund, KAMIA, and MUFJ Capital in 2 rounds.
Sensegon raised $1.9M from JANVEST Technologies LP and Capital Point in 4 rounds.
AgSquared raised $1.7M in 3 rounds.
LawPivot raised $1.6M from Venture51, Quotidian Ventures, Vaizra Seed Fund, Vaizra Seed Fund, Sand Hill Angels, David Austin, Allen Morgan, Deep Nishar, Nishith Desai, Chris Yeh, David Tisch, and Google Ventures in 2 rounds.
Trellie raised $1.6M in 3 rounds.
CromoUp raised $1.6M from Confrapar .
GreenBiz Group raised $1.4M from K Group .
Ovelin raised $1.4M from True Ventures .
RockThePost raised $1.3M .
Glow Digital Media raised $1.3M from Avonmore Developments, Daytona Ventures GmbH, and Project A Ventures .
Slingjot raised $1.2M in 2 rounds.
Simpa Networks raised $1.1M .
Skynet Labs raised $1.1M from SURGEAccelerator, SOSventures, Enterprise Ireland, Mercury Boy ltd, and Startupbootcamp in 4 rounds.
Budge raised $1M from Tony Faure, Hillan Klein, Marc Lipsitz, Bluehawk Capital, Matt Rockman, and Square Peg Capital .
Tawkers raised $1M in 2 rounds.
Tripping raised $1M from Quest Venture Partners, Draper Associates, Erik Blachford, and LaunchCapital .
Starline raised $1M from Confrapar .
FetchBack raised $1M from Metamorphic Ventures, Geoff Judge, and Erik Matlick .
Playmatics raised $1M .
Make It Work raised $1M from Tech Coast Angels and Siemer Ventures .
CAPPTURE raised $1M .
Desmos raised $900K from Mitch Kapor, Kindler Capital, and Learn Capital in 2 rounds.
Admittedly raised $890K from Quotidian Ventures, Joanne Wilson, and Entrepreneurs Roundtable Accelerator in 2 rounds.
Wetradetogether raised $850K from First Atlantic Investment Ltd in 2 rounds.
Loci Controls raised $765K from LaunchCapital, CommonAngels, and landfills .
Carré Technologies raised $750K .
ePrimeCare raised $750K from Confrapar .
"Canal do Credito" raised $750K from Confrapar .
Colored Solar raised $707.9K in 5 rounds.
gogamingo raised $700K .
StudyTube raised $675K from HENQ Invest .
One4All raised $625K from Todd Warren and Brian Arbogast .
247 Techies raised $600K from 500 Startups and Shailesh Rao .
Flooved raised $600K .
CourseWeaver raised $600K from Spartan Innovations .
Marblar raised $600K .
InquisitHealth raised $597K .
OriginOil raised $558.1K in 2 rounds.
EMUZE raised $535K .
Angle raised $500K from Shane Johnson and Hal Brown .
Lover.ly raised $500K from Joanne Wilson, Michael Edwards, Michael Yavonditte, Charles Smith, Anu Duggal, and Rick Webb .
Ingenium Golf raised $452.3K from Global Business Plan and Østjysk Innovation in 2 rounds.
GeekStatus raised $436K from Yahoo! in 4 rounds.
LFS (Local Food Systems Inc) raised $435K .
Sian's Plan raised $400K from E-Synergy .
Pelliano raised $351K in 2 rounds.
Designer Pages Online raised $350K from George Leventis .
Ben Jen Online, LLC raised $350K from S. Ryan West and S. Ryan West in 2 rounds.
Vinny raised $350K .
takokat raised $350K from Chuck Murray, I Jardiolin, and J Mora .
SIVI raised $340K from StartOK Accelerator Fund and Angel Sidecar Fund .
TheBankCloud raised $300K from Alfy Louis .
Planwise raised $285K in 2 rounds.
Callision raised $250K from Jane Basina and Alex Kleyner in 2 rounds.
AttorneyFee raised $250K .
The Innovation Factory raised $250K .
Munchkin Fun raised $230K .
Mapache Studios raised $200K from Innpulsa Colombia and Wayra in 2 rounds.
LawKick raised $200K from Austin Hairfield and Joseph Lifschutz in 3 rounds.
StartupDigest raised $200K from The Kauffman Foundation .
Techfoo raised $200K .
EverCharge raised $200K in 2 rounds.
AddressReport raised $200K .
wiseri raised $162K .
Cyclone Power Technologies raised $150K .
Citizinvestor raised $150K .
GradFly raised $150K .
IDverge raised $125K .
CodeMonkey Studios raised $120K .
StARTinitiative raised $100K .
eRALOS3 raised $100K .
Christophe & Co raised $75K from Andres Moron, Philip Johns, Alex Merino, Airworthy Capital, Dr. Barry Potter, Damian Greco, Josh Petras, Tania Salarvand, Peter Double, Conor O'keiff, Andrew Kalmar, Dr. Sam Yoselevitz, Linda B Potter, and Ralph Mentzer .
DyMynd raised $75K .
inEarth raised $50K from Shervin Pishevar .
Epunchit raised $40K .
Vitryn raised $40K .
Easy Pairings raised $40K from Entrepreneurs Roundtable Accelerator .
Mibio raised $32K .
Upstart Labs raised $30K .
Melon #usemelon raised $25K from HAXLR8R .
SeamBLiSS raised $20K from TechLaunch .
Appfrica raised $15K from KuvCapital .
Flashstarts raised $14K from FlashStarts .
IndyGeek raised $7.1K from John Fox, John Fox, and John Fox in 3 rounds.
Asesorias Digitales (Digital Advisors) raised $6K .


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In keeping with the tradition of the late Alfred Hitchcock, Psycho II director Richard Franklin makes a cameo appearance in his sequel to the Hitchcock original. But you'll have to be quick. Franklin (see photo) is seen briefly playing a video game by the door of the diner as Norman Bates (Tony Perkins) arrives for his first day of work. You'll have to be even quicker to catch a glimpse of Hitchcock, who stood on a street corner, sporting a white cowboy hat, in the original Psycho. Here he appears as a silhouette on the wall in Mrs. Bates' bedroom when Norman and Mary (Meg Tilly) enter the room for the first time. (Ironically, Mary assures Norman, "There are no ghosts here.") By the way, it's not giving too much of Psycho II's plot away to reveal that Universal is planning to take a stab at Psycho Ill.
Some wondered if Jackie Bisset had changed dance partners when she showed up on the arm of Argentinian clothier Roberto Devorik at the opening of a new L.A. restaurant, called Ryan's Place. (Devorik owns Regine's apparel shops in London and West Hollywood.) It seems that Bisset's live-in beau, ballet star Alexander Godunov, was off in Buenos Aires rehearsing for an upcoming tour with the Teatro Colon corps. Though Jackie may play while Godunov's away, word is she still prefers blonds.
They say a picture is worth 1,000 words. At least that many have been used by various sources to describe what happened to the photograph of Barbara Walters that was part of Sotheby's New York exhibit by British photographer Norman Parkinson. According to an eyewitness who attended the gala black-tie dinner on opening night, Walters made a brief appearance shortly before midnight and was stopped by two security guards as she was leaving—with the photograph in hand. Barbara had a spirited exchange with the guards. She finally left the photo behind, and it was returned to the exhibit. It's not known whether Walters loathed the picture, and therefore wanted it removed from the exhibit, or loved it, thereby wanting it for herself. Whatever her motives, she wouldn't say cheese about the incident, nor would she allow us to print the photo.
Dynasty's Joan Collins is sporting a new look for her lead role in ABC's Male Model, now in production. Collins, who plays an Eileen Ford-type modeling maven, has shorn her brunet mane and shed seven pounds. Says Joan, "I want to lose five more so that I look like a New Yorker."
Forget Valspeak. The newest lingo comes from London's post-punk party scene of the affluent WYT (Wild Young Things). According to WWD (Women's Wear Daily), known for its PYT (Pretty Young Things), WYT are known for their lavishly eccentric ballroom attire and their Evelyn Waugh style of hedonism—not to mention their fondness for initials. WYT differentiate between the PLU (People Like Us), the PLT (People Like Them) and the TTFW (Too Tacky for Words). All WYT are just "out for a giggle." But the high life can push even a hard-core WYT, er, OTT (Over the Top). And that, darling, is simply OUTRAGEOUS.
Take One
updated 06/20/1983 AT 01:00 AM EDT
•originally published 06/20/1983 AT 01:00 AM EDT

subset: commoncrawl


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Garden Grove by Lenox
Garden Grove evokes the beauty of the toile style - painting on fabric that was popular during America's Colonial era. In keeping with this artistic theme, Garden Grove features floral clusters in shades of a single color, in this case rich blue. The motif features tiny leaves sparkling with gold, as if touched by dew glistening in sunlight. The white bone china pattern, edged with 24 karat gold, is dishwasher safe. Made in America.See Garden Grove Individual Pieces
Garden Grove 10.75" Dinner Plate
$52.00 $35.95
Garden Grove 6" Bread & Butter Plate
$24.00 $15.95
Garden Grove 8" Salad Plate
$35.00 $23.95
Garden Grove 9" Accent Plate
$50.00 $34.95
Garden Grove Rim Soup Bowl
$80.00 $55.95
Serving Pieces
Garden Grove 13" Oval Platter
$286.00 $199.95
Garden Grove Serving Bowl
$258.00 $179.95
Coffee & Tea Accessories
Garden Grove Cup
$51.00 $34.95
Garden Grove Saucer
$24.00 $15.95
Garden Grove Cup & Saucer
$86.00 $59.95
*Offer valid on Lenox Exclusive items only. Offer excludes all Donna Karan, Marchesa, Reed & Barton, and kate spade new york merchandise.


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About Us
Welcome to Housing and Residential Life at Radford University!
Living on campus is one of the best ways to become connected to the Radford University community. Our residence halls provide close physical proximity to classrooms, labs, the library, student services, and student life facilities. Living on campus also provides opportunities to make instant connections with other students and to become a part of our campus community. In addition to all the benefits of on-campus living listed above, students who live on campus consistently demonstrate higher grade point averages, greater retention, and are more likely to graduate on time than their off-campus counterparts.
Our residential community consists of 15 residence halls and additional apartment spaces for upper-class students. Our residence halls range in size from 120 to nearly 900 students. We are fortunate to have been able to renovate existing halls and are striving to continually improve our residential experience through our residential facilities and programs.
We take very seriously our commitment to provide an environment conducive to living and learning in the residence halls. We sum up our goals for the residential experience through the acronym PRIDE: Passion, Responsibility to Self and Others, Integrity, Development, and Engaged.
Again, welcome from the Office of Housing and Residential Life.
Amber Mullen
Director of Residential Life


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Coyotes in Mountain Brook.
Wild hogs in Gardendale.
An overabundance of deer in Shelby County.
Gaggles of geese in Hueytown.
Armadillos, possums, snakes, raccoons, bats.
The metro area is not immune to the growing problem of wild animals rooting, pet-snatching, garden-eating and over-fertilizing suburbs.
Time magazine this month described the problem as national. In "America's Pest Problem: It's Time to Cull the Herd," David Von Drehle wrote that after nearly wiping out species 50 years ago, we're all living once again "uncomfortably close" to all kinds of creatures.
Tell that to those near Mountain Brook High School, where members of one Facebook group warned of night-prowling coyotes, urging others to lock down their pets.
"The coyotes come out of their den and make their way down to the river, hunt, then return before sunrise," said one member.
Do you have a story of wild animals in your neighborhood? Do you have a suggestion or solution to control wild animals or pests? If so, we'd love to hear from you.
Share your anecdote or photo in the comments below, or via email at email@example.com. And watch for updates in the coming days and weeks.
Earlier: Inverness community hires trapper to catch wild coyotes that are killing pets
North Jefferson County feral pig problem: Large pig killed in Pinson hit-and-run


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The Oklahoma City area held several Veterans Day celebrations on Monday.
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text: Free Red Strike Energy Drink @ MurphyUSA Facebook freebie! Flag this deal What's the matter? Choose a reason Dead deal Duplicate Bad link Spam Inaccurate No value Alive again Edit deal harningt Oct 28, 2010 Got the coupon link... waiting on access to a Windows PC to print... Reply Load More Comments


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Funding, new regulations top 2002 infrastructure policy agenda
Jim Fahey
Director of Government Relations
APWA Washington Office
Diminishing federal resources, budget deficits likely to exceed $100 billion, and significant funding increases to meet homeland defense needs are expected to dominate the Washington policy agenda in 2002. Public works issues also will assume a prominent place as both the Congress and the Bush Administration move forward on a number of pressing issues concerning infrastructure needs, infrastructure security, and the environment.
Drinking Water
In the wake of the attacks of September 11, 2001, shoring up infrastructure security will continue to be a priority for Washington policy makers this year. The U.S. Environmental Protection Agency (EPA) will be distributing vulnerability assessment grants authorized as part of a $20 billion comprehensive anti-terrorism bill approved by Congress in December of 2001. Pending legislation in the Congress includes a bio-terrorism bill to provide $120 million for assessments of water systems. A second bill, Water Infrastructure Security and Research Development Act, passed late last year in the House but awaits Senate action this year. This bill would authorize $60 million over five years for research, development, and demonstration activities to achieve improvements to technologies and related processes for the security of water supply systems.
Drinking water regulatory-related actions expected from EPA in 2002 include the promulgation of a final radon standard for drinking water, work on a secondary standard for MTBE, and development of the Long-Term 2 Enhanced Surface Water Treatment Rule and the Stage 2 Disinfectants and Disinfection Byproducts rule.
Clean Water
This year marks the 30th anniversary of passage of the 1972 Clean Water Act, and several clean water issues are expected to be addressed during the year. EPA is expected to re-propose a Total Maximum Daily Load (TMDL) rule, originally issued July 2000 but pulled by the agency in October 2001. The agency is working to develop a pollutant trading program to incorporate into the rule. Also anticipated during spring of 2002 is a proposed sanitary sewer overflow (SSO) regulation, which was originally signed in January 2000 but never published. In addition, EPA has been working on guidance on wet-weather wastewater bypass and may issue a draft of it soon. In accordance with a court order, EPA will be issuing an effluent limitation guideline (ELG) each month through June 2002, including the construction ELG to establish a national standard for runoff from construction sites, expected by the end of March.
Water Infrastructure Funding
Legislation to provide federal funds for the repair and improvement of aging and deteriorating wastewater and drinking water infrastructure will be considered by the Congress in 2002. Sen. James Jeffords (I-VT), chair of the Senate Environment and Public Works Committee (EPW), and EPW Committee members, Sens. Robert Smith (R-NH), Robert Graham (D-FL) and Michael Crapo (R-ID) will introduce a bill addressing funding of state revolving loan funds (SRF) and ways to make them more flexible. Federal funds are distributed to states to capitalize Clean Water and Drinking Water SRFs, which are used to provide loans to local communities for water infrastructure improvements. The Water Infrastructure Network (WIN)—a coalition including APWA formed to advocate increased investment in water infrastructure—has identified a $23 billion annual investment gap for wastewater and drinking water infrastructure needs over the next 20 years. Last year, Congress appropriated $850 million for the drinking water SRF and $1.35 billion for the clean water SRF.
In 2002, the security needs of the transportation system will remain a priority for the U.S. Department of Transportation (DOT) and the Congress, with efforts to include border security, improved system monitoring, and continued implementation of aviation security measures. In addition, a reported cut of more than $9 billion in TEA-21 (Transportation Equity Act for the 21st Century) funding for 2003 will also dominate the highway transportation agenda this year. TEA-21, a six-year, $218 billion law, provides federal funding to state and local highway and mass transit programs.
In late January, DOT announced that a drop in tax receipts to the Federal Highway Trust Fund will result in a 2003 funding level of $22.7 billion for the highway program, a decrease of nearly one-third from $31.8 billion in 2002. Factors contributing to the revenue decline to the Trust Fund include a fall in the estimated amount of commercial truck travel, which generates diesel fuel tax revenue; higher use of gasohol than estimated (gasohol is taxed at a lower rate than gasoline); and slower growth in the purchases of trucks and trailers (taxes from such purchases go to the Trust Fund).
The funding reduction is required by a budgetary mechanism established in TEA-21 known as Revenue Aligned Budget Authority (RABA), which was created to ensure that highway funding tracks trust fund revenues. As tax receipts rise or fall, funding levels increase or decrease accordingly. Prior to this year, RABA has generated significant increases to levels originally set by TEA-21. This year's policy debate over RABA will likely focus on ways to prevent wide swings in highway program funding.
TEA-21 is due to expire on September 30, 2003. In preparation for its reauthorization, increased oversight activity will occur in 2002 in the House and the Senate. A number of issues are expected to be addressed during this oversight period, including ways to: finance the unmet needs; improve the timeliness of project delivery (also referred to as environmental streamlining); mitigate congestion; enhance program flexibility; meet intermodal needs; and increase local official involvement in planning decisions. In January, the APWA Board of Directors approved APWA's TEA-21 reauthorization policy statement, which appears below in this issue of the APWA Reporter.
To reach Jim Fahey, call (202) 408-9541 or send e-mail to firstname.lastname@example.com.
APWA Board adopts TEA-21 Reauthorization Policy
Andrea J. Fisher
Manager of Government Relations
APWA Washington Office
In September 2003 the Transportation Equity Act for the 21st Century (TEA-21) will expire. In order to identify priorities and advocate successfully on behalf of the APWA membership, an internal 12-member TEA-21 Reauthorization Task Force was appointed by past APWA President Judith M. Mueller.
During the APWA Board of Directors meeting held on January 25-26, 2002, the policy drafted by the APWA TEA-21 Reauthorization Task Force was approved and adopted. The Task Force is led by Chairman, Don LaBelle—Public Works Director for Alameda County, California. The task force has been working diligently on the policy throughout the past year. In December 2001 the Government Affairs Committee approved the policy and forwarded it to the Board of Directors for their review. The adopted policy is provided below.
The next step in the process will be to promote APWA's policy to key lawmakers in Congress, potential allies and other organizations representing transportation interests. Please contact Andrea Fisher in APWA's Washington office at (202) 408-9541 or email@example.com with any questions you may have about the policy or the work of the Task Force.
APWA Policy Statement on the Reauthorization of the Transportation Equity Act for the 21st Century (TEA-21)
The American Public Works Association (APWA), representing public works officials across the nation, strongly supports the goals and programs established by Congress in the Transportation Equity Act for the 21st Century of 1998 (TEA-21) and endorses reauthorization of the legislation retaining its core structure. TEA-21's enhanced role of local decision making and its emphasis on flexibility and intermodal goals have contributed to increased consideration of local concerns. It has also provided for the preservation of existing facilities in transportation spending decisions and greater exploration of alternative solutions to transportation problems. APWA believes that a strong transportation system provides the foundation for a healthy economy.
To build upon the successes, APWA believes that reauthorization of TEA-21 must:
To meet the documented needs, reauthorization must provide increased federal investment for all modes of transportation, including highways, bridges and public transportation. APWA supports full funding of TEA-21 transportation programs at levels consistent with revenues from transportation user fees including earned interest. Further, APWA believes streamlining and reducing the number of regulatory requirements on states and local governments and allowing state and local governments greater flexibility in implementing transportation programs would enhance the goals of TEA-21 and its successor.
The successor to TEA-21 should reflect a reduced federal oversight role on states and local governments while ensuring the effective functioning of a limited National Highway System that supports intercity, interstate and commercial corridors and national defense, as well as both national interests and international mobility.
Roles and Responsibilities
APWA believes the federal government must maintain a leadership role in:
TEA-21 significantly defined and expanded the role of local governments to help shape the transportation outlook for their communities. Through direct suballocation of Surface Transportation Program (STP) funds to urbanized and rural areas and requirements that local governments have a say in spending decisions, TEA-21 brought transportation decision making closer to the citizens that fund the programs. System preservation and review of alternative solutions to transportation problems should be retained in reauthorization. APWA urges Congress to continue support for state-local transportation partnership and provide incentives to encourage all states to work cooperatively with their local government partners.
APWA endorses full funding of TEA-21 and supports increased federal investment by its successor at authorized levels consistent with all revenues received and earned from transportation user fees. APWA supports continued direct suballocation to local governments acting through their designated Metropolitan Planning Organization (MPO) with a greater emphasis on directing expenditures to reconstruction and system preservation, including a direct pass-through and suballocation of maintenance funds allocated to the states and local agencies.
To maintain the integrity and intent of the Federal Highway Trust Fund, as well as to address unmet needs, reauthorization must include guaranteed funding and a funding firewall mechanism which ensures that all funds authorized by Congress and all earned revenues from gas taxes and user fees are appropriated for transportation (highways and transit) purposes and not held in reserve or transferred to other non-transportation programs. TEA-21 reauthorization should limit highway demonstration projects to state Transportation Improvement Program (TIP) projects that meet strictly applied state and local criteria, including approval by local and state transportation authorities. Further, all roadway users should pay motor fuel taxes or some other user fee in proportion to their use of the roadway system.
APWA recommends that direct suballocations be made to all designated MPOs and the two largest cities and counties in each state. Suballocation provisions should also include continuation of funding to areas of less than 5,000 population.
FHWA should ensure that affected local governmental entities are included in the highway and transportation planning process and that 100 percent of all funding from federal gas taxes suballocated for local governmental streets and roads is distributed to local governments or as a pass-through of funds from state DOTs.
APWA supports efforts to promote innovative financing of transportation projects. Many communities have pursued innovative financing and found success in leveraging funds for projects. Even more innovative financing methods need to be considered and available to states and localities to accomplish projects in a shorter timeframe. This includes allowing the local government match to be paid over time through use of state infrastructure bank long-term loans, addition of toll facilities, and/or the sale of bonds to be reimbursed from local operating fees and taxes. Reauthorization of TEA-21 should authorize and encourage state and local governments to apply innovative solutions including privatization, public-private partnerships, joint development projects and public agency toll pricing as ways to address the growing transportation financing gap. It should also encourage the rapid deployment of transportation technology when appropriate for the community.
APWA recommends that Congress establish a special task force consisting of appropriate stakeholders and direct them to address the problem of project delays associated with regulatory requirements from the numerous federal regulations and agencies. APWA also proposes that the task force be given a specific deadline or schedule for providing recommendations to Congress and additionally, consider pilot projects that could explore alternative methods of project delivery.
Programs enacted under TEA-21 are designed and structured to address the multiple, varied and intermodal transportation needs of the states, regions and localities, and as result of this, much progress has been made in meeting identified needs. APWA endorses retention of the surface transportation programs established under TEA-21. Communities have worked hard to carry out the TEA-21 planning process and it should be retained in reauthorization. The process helps communities weigh alternatives to transportation problems and allows more innovative solutions. APWA encourages USDOT to continue its efforts to ensure that the cooperative process between state DOTs, MPOs, and local transportation officials in all areas works effectively and plays a constructive role in furthering the goals of TEA-21.
TEA-21 reauthorization and all federal legislation should restrict or minimize federal sanctions, while emphasizing incentives, and fully fund transportation mandates imposed by Congress through legislation or administrative regulation. Federal mandates and regulations should be required to demonstrate their cost-effectiveness. Full funding should not be at the expense of other transportation programs.
While TEA-21 promised greater flexibility for state and local governments, communities have found much of promised flexibility replaced with new restrictive regulations on the planning process. APWA urges USDOT to carefully evaluate the appropriate level of detailed federal review of projects at the regional level to determine whether a reduction in direct federal involvement might allow greater flexibility in meeting TEA-21 goals, including a reduction in direct federal involvement in the projects. Also, state agencies and MPOs should be encouraged to review their regulatory and technical assistance programs in order to assure a timely distribution of funds. In many cases the larger cities and counties have the capability to carry out the projects without the direct oversight of both the federal and state governments. APWA also supports more flexibility in allowing for contingencies in the planning and funding processes. Without latitude for local flexibility in determining funding sources and amending plans, communities lose the ability to move to the next project in line if an unforeseeable problem develops with a project.
APWA also supports continuation of the Highway Bridge Replacement and Rehabilitation Program, including provisions funding off-system bridge needs, to aid communities to meet the enormous need for bridge maintenance and repair. APWA supports continuation of the Congestion Mitigation and Air Quality Improvement Program (CMAQ), including maintenance areas, and the Transportation Enhancements program set-aside of STP. However, the Enhancement Program should be strictly limited to only those projects that are related to surface transportation. Both of these programs have allowed communities to consider a diversity of projects eligible for federal funding. TEA-21's emphasis on multimodal approaches to transportation programs is critical to improved mobility and responsible transportation decision-making. APWA urges continuation of TEA-21's flexibility to use federal funds on a range of transportation alternatives and the ability to use funds based on local needs.
While APWA supports the use of performance goals as an alternative to direct federal oversight, we encourage USDOT to work with the stakeholders involved in establishing clear broad objectives and mutual criteria for performance goals before USDOT seeks to use them as measures for evaluating performance and making funding decisions.
APWA endorses expanded and continued federal leadership in pursuing technological advances and promoting its role in improving transportation. The federal government should continue to take a leadership role in research, operation, and model deployment of Intelligent Transportation Systems. APWA encourages further deployment of innovative technologies at the local level in rural areas and in urban areas serving local needs. A greater effort should be made to educate local officials on the use of technology innovation through the Local Technical Assistance Program (LTAP) and the Rural Transit Assistance Program (RTAP).


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Here's how you can get SMS alert for free, each time you receive a new email on your Gmail account. This method works with Gmail account only. If you don't have a Gmail account, you can easily create one and then forward the mails from your other accounts to your Gmail account. The SMS works for notification purpose only, you cannot use it to read the whole e-mail. I've explained why, later on at the end of this post. Since the SMS comes directly from Google, you can be quite certain that this will work worldwide. Google Calendar provides an option to send reminders on a particular date/time to your mobile phone as an SMS. We are going to use an application which will create a reminder on Google calendar each time we receive a new email on Gmail. Hence, each time you receive a email, you'll receive an SMS too.
Let's start.
1. Configuring the Google Calendar
As mentioned before, we are going to use Google Calendar to send the SMS, therefore we need to configure it at first.
Go to Google Calendar and in the upper right hand corner, click on Settings.
After that, select Calendar Settings and go to Mobile Setup tab.
Select your country from the Country drop down list and enter your mobile phone number on Phone number field. Then, click on Send Verification Code. You should immediately receive an SMS from Google. Enter the code you just received on the Verification code field and press on Finish setup. You should now see a green sign saying your phone number has been successfully validated. Click on Save.
2. Register on Google App Engine
Open the Google App Engine and login by entering your Google account email and password.
Click on Create Application.
If it is the first time you are visiting the App Engine, you would be ask to verify your mobile number just like before.
Enter your mobile number in international format (for ex. +977XXXXXXXXXX for Nepal) and click on Send. Just because your carrier or country is not listed on the drop down list does not mean you won't be able to receive the verification SMS. If your carrier or country is not listed, select Other and enter your mobile number.
Now, you need to enter a name for your application. The name has to be unique; enter anything you like. Leave the other fields on the page as it is, do not make changes or enter anything other than the Application identifier. I've entered thelacunablog as the application name (or identifier.)
Click on Create Application button. You should see a message saying Application Registered Successfully. If you don't see a similar message, try coming up with a unique application identifier name.
From now on, whenever you see thelacunablog on this post, you should replace it with your application name (or identifier.)
3. Download the application code
Download the application code from here.
Extract the files, for ex. to D:/mail2sms. Then, rename the folder to represent your application name, for ex, in my case, D:/thelacunablog
Now, go inside the folder (i.e thelacunablog) and find the file app.yaml. Open this file in any text editor.
In the first line of the file, replace mail2sms with your application's name. As you can see, I have replaced it with thelacunablog.
Save the file.
4. Download and install Python and SDK
The next part, you just need to download and install two programs.
Download Python from here and install it.
Then, download the SDK Google App Engine from here and install it.
After downloading and installing both the programs, run the Google App Engine Launcher. You should see the program's icon on your desktop or look for it in the Start menu.
5. Deploy the application
Start Google App Engine Launcher from your desktop. Click on File > Add Existing Application
Click on Browse and select the folder that you just renamed (i.e. the folder that contains the application)
Click on OK and then click on Add.
Now we are ready to deploy the application. Click on the Deploy button.
In the next window, enter your email and password. Then press OK.
You'll see a new window and a bunch of texts on it. Wait till you see Process exited with code O on the window (See Below.)
If you see Process exited with code O then the application has been successfully deployed. You can now close Google App Engine Launcher.
6. Configuring the application.
Open your web browser (Mozilla, Chrome, Internet Explorer, Safari etc) and go to your applications page.
In my case, it is thelacunablog.appspot.com
Click on Settings once you get there.
You might be asked to login to your Gmail account. Just login to your account.
Now, the final part is here.
Enter your Email and Password as shown below. Don't forget to mark the check box on Email 1 and Enable SMS. Then Click on Save.
Try sending a new mail to the email address you mentioned above and you'll get an SMS within a minute.
You can enable the night mode if you don't want to receive SMS during night (or any specific time), but you have to specify the time zone properly. We are using Google Calendar in order to send the SMS. So, you'll only receive SMS of length 116 or around, you won't be able to receive all the texts on the e-mail. That's why this method is meant for an SMS alert and not for checking your emails. If you want to see some excerpt of the e-mail anyway, you can click on The Contents check box. You may also mention the Twitter Profile Name or RSS feed link if you want to be updated when someone makes a post on Twitter or on their website.
If you use other mail providers than Gmail, you can always forward those mails to your new Gmail account and hence, receive SMS alert whenever a new email comes to your inbox, be it in Gmail or any other mail providers. One more thing you could do with it is, you could use the gmail address as your primary address on Facebook and receive SMS alert for any new notifications on Facebook.
Source : gmail2sms.blogspot.com


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Scott Cullen at TSN says because the Rangers look like a contender in the Eastern Conference they would have to get roster players in return for any trade involving Ryan Callahan and/or Dan Girardi since a playoff team can't justify dealing prominent players for no immediate help.
Glen Sather is reportedly still committed to trading the two home grown Rangers if they can't agree on an extension by the March 5th trade deadline.
…i'm not sure I agree with Cullen. The return package for either Cally or Girardi will depend on the direction Sather wants to take this team. If he's not confident in the team's chance this season then he'll attempt to get as many first round picks and top prospects as possible. However, if Sather thinks the Rangers have legit Stanley Cup aspirations, then yes, I can see him trying to replace the two for a playoff run if he can't get them re-signed.
…despite the crazy numbers flying around and the trade threats, I still can't envision Sather trading these two guys. I think they'll both ultimately re-sign. Having said that, don't underestimate Sather at the trade deadline.
Remember to follow me on Twitter & Facebook or e-mail me at email@example.com.


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this week the big time gamblers are on
Pit -1.5
sd -8
was +6
What it is... the people get 5 picks a week each person pays 1,500 to get in and end of the season the person with the best record wins.. Lots of good gamblers on this.. I have been watching it for a few weeks they are doing pretty good.. worth a look if you are between picks.
Does anyone else kep track of this?
Copyright © 1995-


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Road work planned in Gasoline Alley
Roadway improvements will begin this summer to eliminate traffic snarls at a busy T-intersection near Staples and Costco on the west side of Gasoline Alley.
On Tuesday, Red Deer County council approved Central City Asphalt Ltd.'s bid to do work along Leva Avenue from McKenzie Road to Waskasoo Avenue.
The work will involve building an additional southbound lane along north-south Leva Avenue. It now has three lanes, two of which are northbound.
A roundabout, a modernized traffic circle where drivers must always yield to traffic already in the circle, will be built at Lantern Street and Leva Avenue.
It will be constructed on the corner leading to Staples and Costco, so the majority of road construction won't affect traffic.
"We don't want to disrupt traffic anymore than we have to," said County Mayor Jim Wood. "People will be somewhat inconvenienced, but they're going to like to be able to drive on the road when it's done."
Wood said the current T-intersection has become a real problem for traffic because drivers are coming off of Hwy 2 and into the area.
Plus, drivers are trying to come off or onto Leva Avenue. It's been a real inconvenience for businesspeople.
Wood said this plan has been well received from employers in the area.
"It's recognized that any construction will have some slowdown in the area," said Wood.
"It will be minimized to the best we can. We want to see Gasoline Alley continue to prosper and not have traffic stopped all the time."
He added that a service road running along Hwy 2 will be open so traffic would be able to access that during construction.
"We will be doing lane widening on Leva, which already has three lanes, so we should have traffic flowing there most of the time."
Wood said the roundabout was the best solution for the area because in that way, drivers coming from Hwy 2 wouldn't have to stop.
Central City Asphalt Ltd.'s bid of $6.4 million came under budget. Part of the construction, where work needs to tie in Leva Avenue north of Lime Street, will be funded by the provincial government. Red Deer County's portion of the cost ends up being $5.3 million as a result.


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On last week's episode of Tori and Dean: Home Sweet Hollywood, we saw Tori Spelling fight back the tears. This week, the drama was all her husband Dean's.
After a busy day of looking for preschools for 1-year-old son Liam, Dean got emotional thinking about Jack, his 9-year-old son currently living in Canada with ex-wife Mary Jo Eustace. "Liam's not going to suffer my stumbles and my faults as a dad the first time out," Dean said, holding back tears. "I feel like a really bad dad with Jack."
"But that's one of the reasons I chose you," said Tori. "You're a really great dad to Jack."
Besides Dean's guilt pangs, we saw the ups and downs of parenting in Hollywood. Tori learns from her OB/GYN that Liam's pre-school applications were months overdue. We also learn that Tori will definitely reprise her role as Donna Martin on the CW's 90210 spin-off.
"Donna Martin's back," cried Tori, "and she's very fertile!" -- Jessica Gold HaralsonOxygen
Tori & Dean Deal with Parenting Dilemmas


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|Parliamentary Evening 2009
|Film Award in Cannes
|Moving images are worth as many explanations
|2nd International Conference on HIPIMS 2011
|3rd International Conference on HIPIMS 2012
4th International Conference on HIPIMS 2013
|INPLAS Talks 2011
|INPLAS Talks 2012
|Wind power workshop 2012
|INPLAS Talks 2013
|Wind power workshop 2013
|INPLAS is 10!
|6th International Conference on HIPIMS 2015
The Bosch Group is a leading global supplier of technology and services. In the areas of automotive and industrial technology, consumer goods, and building technology, more than 300,000 associates generated sales of 51.5 billion euros in fiscal 2011. Bosch spent some 4.2 billion euros for research and development in 2011, and applied for over 4,100 patents worldwide.
For many years the Bosch group concentrates on thin, in vacuum applied wear resistant films. These, e.g. diamond like carbon films, were particularly developed for components of high pressured injections of fuel, applying various plasma processes and thin-film technology.


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Tuesday, March 17, 2009
Selling a Lie
No, this isn't a post about the economic "crisis/non-crisis/worst-ever-crisis" acrobatics coming from the White House. Nope, it's about a woman who wants to get her son laid. Unfortunately for the boy, he has Downs Syndrome and can't quite close the deal on his own--which, if we were to be completely honest, isn't a surprise since he's running with a serious handicap in this particular horse race.
I'm not going to debate the wrong or right of pleading and potentially paying for someone to do naughty things to her boy (although I'm curious if she would go to the same lengths if the kid were on the other side of the gender fence). What I am going to quibble with is this:
"I strongly believe, and have always said, that society has a learning disability when it comes to Down syndrome," she continued. "If he doesn't get a girlfriend, I will feel really bad, because I have sold him this thing that he is like everybody else. That's why I'm working overtime to get this sorted for him."
If you have to break out the checkbook to get your twenty-one year old adopted son a shot with a woman, then he isn't like everyone else. This isn't a value judgment about the kid, nor is it saying that he has to live the life of a social recluse, shuttered away from polite society because he isn't good enough to be around the rest of us. I'm not saying that his life is a useless thing.
But the idea that he is "just like the rest of us" is clearly a social nicety that folks play along without out of a sense of decency. 'Cause he isn't like everyone else-- which all rational people would probably agree with even while many try to keep up the "treat them just like everyone else" face because no one wants to be seen as the heartless bastard. But his mental faculties aren't the same, the way he processes information isn't the same, the kind of opportunities that he will have in life because of that simply are not the same as for an average person without Downs Syndrome.
I'm not a heartless bastard, but I don't think that self-deception is a great place to start when deciding what kind of help you want to render to a horny, socially limited, young adult with Downs Syndrome.
Read the story. The comments on the original story (here) are an interesting read as well.
Comments & Trackbacks
The main thing that strikes me about this is it's just a microcosm of the larger issue. This goes on in public schools, e.g., a lot. There's this whole errant notion about not damaging fragile egos, keeping up self-esteem, etc., that keeps teachers and administrators from passing judgement on poor performance. And I'm not saying that having Down's Syndrome is a failure. But just as there's a problem with "selling" him on the notion that he's just like everybody else, there's also a problem with treating poor students just like exceptional students.
This sort of fuzzy thinking is responsible for so many problems we face today ... I'll just stop now.
You know how, as soon as the Waterboy stopped talking about Momma all the time, he got a piece?
Way to overparent your child, mom.
As was so eloquently stated in The Incredibles: "If everyone is special then no one is." Same logic here…
One of my favorite movies. The last one, actually, that caused me to say at the end of the showing, "The day that comes out on DVD, I'm buying it!"
That said, the problem here is not merely what the mother's doing, and Jed's description of the problem; it's also the probably double standard behind it. She wants her son to be just like anyone else, but I sincerely doubt that she's doing without assistance in paying for him. People with Down's are often, perhaps even usually, incapable of taking care of themselves. He'll likely need support (which translates into governmental support) his entire life, which is not like "everybody else."
Unfortunately, that seems that "everybody else" is getting more dependent as time goes on.
The problem is the Happy Meal Generation. The idea that we're all SO entitled to shit. If we eat a meal, we deserve a toy. Couple that with some good Helicopter Parenting, and you've got problems.
I bet that kid wouldn't know the difference is mom wasn't trying to get him laid. Which isn't the issue, for me, but the fact that his mother is trying to get him laid is. Um, EWW? That has got to be the most inappropriate invasion into a child's life a mother could make. I'm surprised it's LEGAL.
These over-involved, don't yell at/correct/scold/point out any weakness in my child parents are RUINING THE WORLD. Ann Coulter thinks it's the single mothers, I think it's the suburban housewives.
The "most inappropriate invasion" into a child's life? I'm not sure I agree. Before my time (or maybe just in different strata of society) it was not uncommon for a man to provide his son with such an introduction to women as a rite of passage. Overall, society was different then, though - "good girls" didn't until married, shame was a tool enforcing societal mores, and all the other concomitant changes from society today. You (or I, at least) can understand the justifications they used.
That said, it's still creepy.
As for the rest of your comment, I blame Dr. Spock.
I blame people's inability to look beyond their own uteruses.
Or, at least, to realize at some point in their lives that IT'S NOT ALL ABOUT YOU. Not you, specifically, Wheels. We both know it is, really.
Seems to me that the real reason why this kid can't get laid isn't because he's retarded, but because he's likely gay. He is involved in the theater after all…
Rather surprised the possibility wasn't floated in any of the articles linked or in the comments here, actually.


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Conference Menu
Overview Pre-Conference EventsRegister PDF DownloadConference-at-a GlanceDistinguished FacultyPosters Hotel & Travel Sponsor / ExhibitPress Pass Request Brochure
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3:00-4:00 Conference Registration
4:00-4:10 Welcoming Remarks from Conference DirectorJulia Boguslavsky, Cambridge Healthtech Institute
4:10-4:15 Chairperson's Opening Remarks
4:15-4:40 Five Characteristics of a Biomarker to be Useful for Personalizing MedicineFelix Frueh, Ph.D., Vice President, Research & Development, Personalized Medicine, Medco Health Solutions, Inc.
4:40-5:05 Biomarkers for What? Diagnostic, Prognostic or Predictive?Sudhir Srivastava, Ph.D., Chief, Cancer Biomarkers Research Group, NIH National Cancer InstituteBiomarkers have been touted as a next frontier in the realm of personalized medicine. However, one has to be specific and clear about its intended use: Diagnostic, Prognostic, or Predictive? Each type has a different purpose. Each has to meet certain criteria to be fit for the purpose. Therefore, when discussing biomarkers, one must clearly state its targeted goal and population.
5:05-5:30 Building a Biomarker Information Pipeline and Enabling Translational and Personalized Medicine: Leveraging Industry Standards to Bring Omics Closer to MedicineMartin D. Leach, Ph.D., Executive Director, Basic Research & Biomarker IT, Merck & Co., Inc.
5:30-6:30 Opening Reception in the Exhibit Hall
Genomic Biomarkers | Protein Biomarkers | Metabolic Biomarkers | Biomarker Data Analysis
7:00 Registration Open
7:30-8:15 Morning Coffee or Technology Workshops(Sponsorship Available. Contact Ilana Schwartz at 781-972-5457 or firstname.lastname@example.com.)
7:30 Breakfast Workshop
Biological Variation Based Data Interpretation. Why Can This be of Value?Gordon F. Kapke, Ph.D., Senior Director of Biomarker Services, Covance Central Laboratory ServicesWith the emphasis on biomarkers to improve drug development the question arises as how to interpret the data. The traditional clinical laboratory methodology for interpreting data involves the identification of the expected values (the normal range) and from this range defining the probably of disease or no disease (sensitivity and specificity). The challenge in drug development is in monitoring the patient overtime while identifying if important changes have occurred in the biomarker values that indicate inappropriate toxicity or demonstrate appropriate efficacy. The use of the reference interval as a means of identifying toxicity or efficacy will be challenged and an alternative approached based embracing biological variation will be proposed.
(Shared session between Genomic Biomarkers and Biomarker Data Analysis)
8:30-8:35 Chairperson's Opening Remarks
8:35-9:00 Biomarkers: Understanding the Disease ProcessMichael N. Liebman, Ph.D., Senior Institute Fellow, Windber Research Institute; and Managing Director, Strategic Medicine, Inc.Measurement of gene expression data presents an opportunity to further classify patients and their disease using biological specimens, robust experimental methods and statistical analysis to enhance clinical decision making. It is critical, however, to appropriately evaluate this perspective on patient and/or disease stratification in terms of the complexity of the disease process and clinical need, rather than solely on the concept of a disease state. This presentation will describe both the conceptual framework for understanding the relationship between biomarkers and the disease process and results from its application in breast cancer.
9:00-9:25 NextBio - Searching Large Scale Biological Data for Metabolic Syndrome X BiomarkersJames Flynn, Ph.D., Field Application Scientist, NextBioNextBio presents a powerful research tool to analyze Metabolic Syndrome X, one of the most complex and pervasive medical conditions that combines several disorders into one. Patients with Metabolic Syndrome X exhibit clinical signs of diabetes, obesity, dyslipidemia, hypertension and heart disease. This fact underscores the complexity involved in the study of this disorder and highlights the value of NextBio, which enables researchers to look at the interplay of various disease pathways. In this talk, we will demonstrate diverse search strategies for the discovery and validation of Metabolic Syndrome X biomarkers and drug toxicities through NextBio. NextBio's collection of public experimental data will be used to explore mechanisms of potentially applicable compounds, discover tissue specific expression profiles associated with the disease and drill into the interplay of relevant pathways (such as lipid metabolism, glucose metabolism and inflammation).
9:25-9:50 Ingenuity Pathways Analysis: Prioritization of Biomarker Candidates from Omics Data Based on Phenotypic Association Deborah Riley, Ph.D., Senior Application Scientist, Ingenuity SystemsAs gene expression profiling has matured to become a common component of biomarker discovery programs, the challenge has shifted to translating large scale datasets into biomarkers that can be used to diagnose disease and predict patient response to treatment. Prioritization of biomarker candidates requires – at a very practical level - an understanding of candidates' expression patterns in bodily fluids and target tissues and - at the mechanistic level – identification of biologically plausible paths between candidate markers and the physiological responses, cellular phenotypes, or disease processes of interest. In this session we will present a case study in which the biomarker discovery tool IPA was used to prioritize biomarker candidates and elucidate the molecular mechanisms connecting those markers to disease phenotypes and pathways.
9:50-10:15 Defining Health at the Molecular LevelMartin Grigorov, Ph.D., Head of Bioinformatics, Nestlé Research Center
The challenge for the Life Sciences in the new century resides in promoting health and in preventing disease. In order to meet this challenge, knowledge should be built to define and better understand the function of the molecular markers which define the healthy status of a biological system. The aim of the present study was to generate a map of gene expression patterns along the human healthy adult gastrointestinal tract in order to use such sets of biomarkers as references when screening for pathological deviations. Nearly 150 marker genes were found to perfectly discriminate the five major GI regions considered. Fourteen had never been described in the GI tract, and six were novel genes. This work offers a perspective on nutrition-specific biomarkers discovery programs. It shows such studies to be complementary to typical drug development programs focusing on disease-specific biomarkers, rather than on the molecular signatures of health.
10:15-11:10 Networking Coffee Break with Poster and Exhibit Viewing
11:10-11:35 Lost in Translation: Factors Affecting the Clinical Uptake of Molecular DiagnosticsJudd Staples, Director, Translational Initiatives, Corporate and Venture Development, Institute for Genome Sciences & Policy, Duke UniversityThis presentation will explore the barriers to translating new molecular diagnostic discoveries into clinical practice. We will provide a framework to assist researchers in critically evaluating the potential applications of their discoveries and suggest an approach to maximizing the chances that their invention ultimately has an effect in the management of patient care. Topics that will be covered will include assessment of the value of the technology from the perspective of the patient, the healthcare provider, the investor/strategic partner, regulators, and payers.
11:35-12:00 Title to be AnnouncedAlberto Gutierrez, Ph.D., Deputy Director, New Product Evaluation, Office of In Vitro Diagnostic Device Evaluation and Safety, Center for Devices and Radiological Health, U.S. Food and Drug Administration
12:00-1:40 Luncheon Technology Showcases
An Automated and Streamlined Solution to Increase Productivity and Confidence in Microarray StudiesJean-Francois Olivier, Ph.D., Affymetrix
This case study highlights the increase in productivity and confidence in microarray results for whole genome expression analysis using a microplate-based high throughput platform. The platform includes automated target preparation, an array processing instrument and complementary reagents that minimize hands-on time. Applications in drug discovery and development will be discussed.
Cancer DSA™ - Disease Focused Microarrays: A Platform for Biomarker Discovery and Validation, Optimised for Use with FFPE TissueAustin Tanney, Ph.D., Scientific Liaison Manager, Almac Diagnostics
WideScreen™ Assays for the Multiplex Detection and Quantitation of Cell Signaling Proteins and Serum BiomarkersLaura Juckem, Ph.D., R&D Senior Scientist, Multiplex Assays, EMD Chemicals, NovagenBead-based immunoassays allow multiplex analysis of 5-20 protein analytes from a single sample. This session will discuss select WideScreen™ Assays and their use in the characterization of cell signaling events and in the analysis of serum biomarkers. These assays include:
·Multiplex assays to analyze the expression and tyrosine phosphorylation status of several key receptor tyrosine kinases, enabling the profiling of protein kinase inhibitors in a cellular context.
·An assay that uses EpiTag™ Technology (Epitome Biosystems) for the simultaneous, multiplex quantitation of total and phosphorylated ERK pathway proteins in a single well.
·Highly validated and functionally defined serum biomarker panels developed in partnership with Rules Based Medicine.
1:40-1:45 Chairperson's Opening Remarks
1:45-2:10 Personalized Healthcare – Where Are We Now?Ruth E. March, Ph.D., Director, Personalized Healthcare Science and Technology; Lead, Personalized Healthcare Team, AstraZenecaThis talk will examine what Personalized Healthcare (PHC) is, its current state and its main beneficiaries. We will then examine what makes for successful PHC development and what are the main challenges. This will be illustrated by case studies including Iressa®, Exanta™ and products from AstraZeneca's early development pipeline. The talk will demonstrate that PHC is at an exciting time and depends on all those involved working together to realise the benefits.
2:10-2:35 Novel Computational Tools for Translating Genomic Biomarkers into Clinical Practice: Case for WarfarinSaeed A. Jortani, Ph.D., Director, Toxicology, University of Louisville Hospital Laboratory; Associate Professor, Pathology and Laboratory Medicine, University of Louisville School of Medicine
There is a combination of clinical, scientific, and regulatory evidence supporting the adoption of pharmacogenetic-guided dosing for warfarin (Coumadin). This drug is the most commonly used oral anticoagulant medication, currently taken by four million people in the US who are at risk for blood clots and strokes. Because the proper warfarin dose per patient is difficult to assess, most physicians take an educated, ballpark guess, and follow up with a blood test to ensure the medicine is working properly. Confounding this is the fact that therapeutic warfarin doses vary significantly from patient to patient, so that even a "standard dose" can cause life-threatening hemorrhaging. Despite the evidence supporting adoption of pharmacogenetic testing for warfarin dosing, it is not yet clear how clinicians will incorporate this new discipline into their clinical decision making. We have developed a computational decision support module for translating pharmacogenetics laboratory test results into clinical action.
2:35-3:00 Genomic Biomarkers: Examples for Discovery, Utility, and ImplementationAndrew Grupe, Ph.D., Senior Director, Pharmacogenomics and Director, CNS Research, CeleraResults from studies across several disease indications suggest that prognostic genetic markers represent excellent candidates for predictive biomarkers. A specific example for a genetic risk factor of cardiovascular disease that also predicts the reduction of cardiac events after statin treatment will be presented. Furthermore, the impact of genomic biomarkers on clinical trial design and the timeframe for developing and implementing a molecular diagnostic test will be discussed.
3:00-4:00 Networking Refreshment Break with Poster and Exhibit Viewing
4:00-4:25 Pharmacogenomics Data: Transmission and SubmissionJoyce Hernandez, Ph.D., Manager, Global Data and Information Standards, Merck Research Labs; and Philip M. Pochon, Ph.D., Enterprise Information Architect, Covance Inc.The emerging use of pharmacogenomic drug metabolism and disease markers in drug development research has sparked considerable interest in the transmission and reporting of pharmacogenomic data. The FDA has recently issued a final guidance on the voluntary submission of pharmacogenomic data, and CDISC and HL7 teams have been actively developing models and vocabularies for this data. This presentation provides an overview of the proposed CDISC/HL7 pharmacogenomic data standards, which include a pharmacogenomic extension to the CDISC/HL7 LAB message, and three new domains within the CDISC SDTM. Example data sets are used to show how the detailed data of the CDISC/HL7LAB operational standard populates the SDTM biospecimen, pharmacogenomic specimen and pharmacogenomic result domains. Example of sequence based and gene expression based analyses are shown. A final section discusses proposed pilot projects using the models to submit data under the FDA Voluntary Genomics Data Submission program.
4:25-4:50 DNA-Guided Medicine in the Management of Cardiovascular and Psychotropic DrugsRichard L. Seip, Ph.D., Senior Physiologist, Genomas, Inc.Genomas is a biomedical company advancing DNA-Guided medicine with PhyzioType™ systems for personalized healthcare. A PhyzioType System has 3 components: an ensemble of inherited, stable genetic markers (single nucleotide polymorphisms, SNPs) from various genes, a biostatistical algorithm validated in clinical studies for ascertaining the clinical significance of a patient's SNPs, and a portal for doctors to select drugs based on an individual's risk of developing side effects. By comparing side effect risks of drugs in a therapeutic class for each patient and by forewarning doctors of adverse responses that will complicate treatment, PhyzioType systems substantially enhance patient safety. PhyzioType systems in development for statins, atypical antipsychotics, and glitazones will be described.
5:15 Close of Day
7:30-8:15 Breakfast Presentation An Integrated Quantitiative Mass Spectrometric Workflow for the Discovery and Validation of Protein Biomarkers Using Tandem Mass Tags (TMT®)Dr. Rainer Voegeli, Commercial Director, Proteome Sciences plc.The establishment of highly specific and sensitive validation assays is a key task to transfer candidate biomarkers from discovery into validation studies. In response to the limited availability of ELISA's, single and multiple reaction monitoring (SRM, MRM) is emerging as a highly selective and sensitive approach for the quantitation of proteins. Here we present an integrated workflow for discovery, assay development and validation studies which utilises chemical labelling by Tandem Mass Tags (TMT). In discovery mode up to six samples are labelled with different colours of TMT, mixed and subsequently analysed by Tandem Mass Spectrometry in a single assay run. From individual samples generally >1,000 peptides and proteins are analysed. Peptides and proteins are selected as candidates for validation if they appear differentially regulated, and meet appropriate biostatistical properties across an adequately powered discovery study. Assay development is then performed using peptides unique to the candidate biomarkers. By combining MRM with peptide labelling by Tandem Mass Tags TMTzero (label mass: 224 Da) and sample labelling by TMTsixplex (label mass: 229 Da), peptide pairs are generated which exhibit perfect co-elution and show a mass difference of 5 Da per added Tag. Quantitation against a reference labelled with TMTzero is so made possible whilst maintaining the selectivity/specificity of MRM combined with the superior sensitivity of Triple Quadrupole instrumentation. This approach allows the very fast transfer of discovery candidates into high quality assays and alleviates the need for immunoassay development or the synthesis of heavy-isotope labelled peptides (as routinely used in MRM's).
8:35-9:00 Discovery of Gene Expression-Based Pharmacodynamic Biomarkers in Tumor ImmunotherapiesZenta Tsuchihashi, Ph.D., Group Leader, Oncology Clinical Biomarker, Discovery Medicine and Clinical Pharmacology, Bristol-Myers Squibb Co.
Gene expression profile analysis in 'clinically available' tissue samples such as tumor biopsy and peripheral blood provides a powerful tool in discovering novel pharmacodynamic biomarkers. This approach is especially useful in the immunology area, as these tissues samples do contain immune cells that are the targets of the drug action. These biomarkers are useful in both understanding the key mechanism of action, as well as optimizing the use of these drugs. A gene expression based 'hypothesis-free' approach complements the more traditional 'hypothesis-driven' biomarker analyses in immunology including flow cytometry and immunohistochemistry, and is especially useful when the detail of the drug action is not well understood.
9:00-9:25 Noninvasive Safety Biomarkers of Germinal Center Atrophy and InfectionEric R. Fedyk, Ph.D., Head, Inflammation Biology & Immunotoxicology, Non-Clinical Development Sciences, Millennium Pharmaceuticals, Inc.
The pathology of autoimmune disease is characterized by recurrent chronic inflammation. Successful therapeutic intervention requires immunosuppression, however not of a magnitude that predisposes subjects to infection, a current safety risk, particularly in outpatient settings (ex. rheumatoid arthritis). Dosing patients for "efficacy without infection" is an elusive endeavor with contemporary therapeutics, largely due to inherent heterogeneity among subjects. Recent development of noninvasive, antecedent biomarkers of immunosuppression and infection, in genetically heterogeneous primate models, has the potential to improve dosing of subjects in clinical trials and patients in clinical practice.
9:25-9:50 Genomic Biomarkers for Early Screens for Non-Genotoxic CarcinogenicityNandini Raghavan, Ph.D., Principal Biostatistician, Non-Clinical Biostatistics, Johnson & Johnson Pharmaceutical Research & DevelopmentGenomic drug safety screens will accelerate the process for developing safer drugs and limit the failure of drugs in late stage development due to toxicity issues, by identifying potential toxicity issues early in the development process. As a result, there is now heightened interest in developing biomarkers for predictive toxicology and risk assessment using toxicogenomic technologies from pharmaceutical companies as well as from governmental agencies worldwide. In this talk we describe the development of a gene-expression based signature to predict non-genotoxic carcinogenicity with high accuracy, using 24 hour microarray experiments on rats. This is especially critical, since short-term assays for non-genotoxic carcinogenicity, which is commonly observed in long-term rodent studies, have proven difficult to develop. We also discuss the need for validating and standardizing gene signatures, to make them portable across platforms, technologies and experimental protocols and eventually applicable for regulatory use.
10:50-11:15 Optimal Biomarker Approach: Data Analysis Considerations of Individual, Panel or ProfileStephen Naylor, Ph.D., Chief Executive Officer & Chairman, PPM, Inc.
The advent of relatively high throughput and broad analyte coverage analysis in "omic" measurements has reignited a debate about what constitutes the optimal biomarker solution. Is it a single analyte per biological event, or a panel (3-10 analytes) or even a profile (>20 analytes)? This will be discussed in the context of statistical and data analysis as well as data mining characteristics.
11:15-11:40 Panel Discussion
11:40-1:10 Luncheon Technology WorkshopEnabling Drug Development Through Multiplexed AssaysMonica Erico, Ph.D., Scientific Services, Meso Scale Discovery
Meso Scale Discovery (MSD) has an electrochemiluminescence platform that is fast (1-3 minutes per plate independent of plate density), robust (non-fluidics instrument), radioactive free, sensitive (detection limits near 10 attomoles) and has a wide dynamic range (5 logs) with multiplexing capabilities. The performance (sensitivity, reproducibility, and ease of use) of multiplexing cytokines, cell signaling pathways, and multiplexed toxicology biomarkers assays will be presented. Development of multiplex panels for complex matrices is challenging because of varying levels of biomarkers, interfering substances in the sample, and interactions between proteins measured. The platform allows for simple assay development that can greatly reduce the amount of time to develop novel assays. The combined properties of the system provide both a cost and time savings with a highly quantitative assay format while improving productivity.
11:40-1:10 Luncheon Technology WorkshopMultiplexed Biomarker Assay DevelopmentMichael Pisano, Ph.D., President and CEO, NextGen SciencesBiomarkerexpress™ is a suite of mass spectrometry-based biomarker services that utilize proprietary methods to significantly decrease timelines and increase the success rates traditionally associated with biomarker development. The services include discovery of protein biomarkers, development of protein biomarker assays, testing biological samples utilizing the assays to determine levels of protein biomarkers.
Case Study 1: Discovery and Assay Development for Putative Biomarkers of Lung Cancer Progression
Case Study 2: Assay Development for a Panel of 30 Biomarkers for Alzheimer's Disease
(Shared Session)
1:10-1:15 Chairperson's Opening Remarks
1:15-1:40 Integration of Metabolic and Transcriptomic Profiling for Understanding of Diabetes and Obesity MechanismsChristopher B. Newgard, Ph.D., Director, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center
Type 2 diabetes is a disease that occurs as a result of metabolic dysfunction in multiple tissues, including most prominently liver, skeletal muscle, and the pancreatic islets of Langerhans. An understanding of the transcriptional and metabolic networks that control normal functions in these tissues, and identification of the network elements that are perturbed during development of type 2 diabetes, are essential steps in the development of new therapies for the disease. The value of targeted mass spectrometry-based profiling of key clusters of intermediary metabolites for identifying specific network perturbations will be highlighted, as will recent examples of integration of metabolomic and transcriptomic profiling for identifying heretofore unrecognized regulatory pathways.
1:40-2:05 Integrating Gene and Protein Expression Biomarkers in a Systems Biology Approach to Colon CancerMark R. Chance, Ph.D., Director, Case Center for Proteomics; Director, Center for Synchrotron Biosciences; Professor, Department of Physiology & Biophysics, Case Western Reserve University
Protein interaction networks are at the heart of functional control of human disease. Network and pathway modeling driven by Omics based approaches are increasingly important to our understanding of disease progression and drug responses. However, deriving and validating network models are complex research problems requiring integra tion of multiple types of high-throughput data. We have recently employed a systems biology approach to find small networks of proteins discriminative of late stage human colorectal cancer (CRC). Expression proteomics studies were initially used to identify proteins differentially regulated when comparing normal and late stage tumor tissues obtained from adequately sized cohorts of human patients. Proteins identified by these experiments were used to seed a search for protein-protein interaction networks selective for biological relevance to the human colon. We chose four significant networks returned by this search and illustrated using measures of mutual information, calculated using gene expression data, that certain protein "signatures" within each network are highly discriminative of late stage cancer versus control. These signatures would not have been discovered using only proteomic data, or by merely clustering the gene expression data. Expanding these signatures by a single hop generated four sub-networks, which were analyzed for biological relevance to human CRC. A number of the proteins in these sub-networks have been shown to be critically involved in the progression of CRC. Others have been recently identified as potential markers of CRC, and still others merit follow-on experimental validation for biological significance in this disease. This general approach can be applied to network modeling for a number of diseases.
2:05-2:30 A Systems Biology Approach to Biomarker DiscoveryKarin Rodland, Ph.D., Science Lead for NIH Programs, Pacific Northwest National Laboratory
Efforts to identify biomarkers for early diagnosis or prognosis of cancer and other disease have often focused on a singular molecular species, with preference given to mRNA, microRNA, proteins, autoantibodies or metabolites based on available technologies and model systems. Each one of these measurements provides a snapshot of cell function, but a dynamic understanding of disease processes really requires the integration of all these modalities to the extent possible. Particularly in the context of using biomarkers to guide therapeutic interventions, it is necessary to understand the relationship between changes in expression, and changes in function. One aspect of systems biology is the integration of heterogeneous datasets to define relationships that predict function. This talk will describe the application of this approach to models of chronic obstructive pulmonary disease.
2:30-2:55 Connecting the Biomarker Dots in Cancer and Neurodegenerative DiseasesIra L. Goldknopf, Ph.D., Director, Proteomics, Power3 Medical Products, Inc.
The application of fundamental principles to Omic integration to address unmet clinical needs will be illustrated with examples from cancer and neurodegenerative diseases. The integrations relate analytical with clinical validation across different analytical processes and platforms; clinical diagnostics with assessment of severity, disease progression, and efficacy; and data analysis integrating proteomic and genomic biomarkers, post-translational modifications, and protein isoforms. The clinical applications cover testing of blood serum for early detection of breast cancer as well as for early differential diagnosis and monitoring of the neurodegenerative diseases. The attainment of biological significance in terms of monitoring mechanisms of disease through blood testing as well as practical clinical diagnostic applications of such testing will also be discussed.
3:00 Close of Conference


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Relearning How to Eat
My brownie points caught up with me. I was really dragging my feet in regards to the whole New Year's Resolution game, its soo… cliché. Yet, I've had that little voice nagging me inside my head since before Thanksgiving- yesh! I sure took my time to act didn't I? Reading Debbie's posts on Words to Eat By put another voice in my head… reading her insights about her struggle with weight is inspiring and familiar, and she's letting us all in on the inner workings of her plan.
Walking to Sushi Station last night, my Sweetie pulled my health desires out of me, making me verbalize what has been making me grumble inside. It was a good walk. We're going to do this together, none of this me making a separate meal for myself thing. Eating healthy will help bring my weight down and will help with Sweet's blood pressure problems.
As if the sushi gods had heard our promise, they rewarded us with new offerings on the sushi round-about… plates of fresh fruit! We started and ended with fruit and had some very nice tuna inbetween.
We decided we're going to follow the DASH eating guide, as outlined in the 2005 Government Dietary Guidelines. This cuts out eggs, which is going to be difficult at times. This adds more vegetables and fruit, and a more conscious consumption of water. We're keeping food diaries and using nifty grid charts to mark off what food groups we've eaten through out the day. I find this very helpful for when dinner time comes around… I look at the chart and see what I have to knock of for the day (usually vegetables).
I'm working on printing out one of my elevator signs for work… though I'm happy to say I haven't seen the inside of the elevator all week.


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Mikel Luster participates in the Costume Class as part of the Pat Flynn Memorial Horse Show at the Little Bit Therapeutic Riding Center in Woodinville.
Where can you see a giant carrot or a draft horse dressed as a fire engine with two Dalmatians aboard for the ride? This year's Pat Flynn Memorial Horse Show, June 8 and 9 at the Little Bit Therapeutic Riding Center in Woodinville, will feature these unusual sights and more.
The public is invited to share the smiles and pride on the faces of more than a hundred riders with disabilities, from Washington, Oregon, and British Columbia, as they take part in this inspiring event which focuses on achievement and good-natured fun.
Areas of competition include equitation, obstacle, dressage, jumping classes, the entertaining coaches' surprise class, and the imaginative costume class.
The show begins begins at 8 a.m. each day and usually ends before 5 p.m. on Sunday. Volunteers or class sponsors are still needed for the event. If you can help or if you need information, call Tracy McConnachie or Laurie Tatalick at 882-1554.