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Biomaterials (v.33, #14)
Editorial board (IFC).
Strategies to reduce dendritic cell activation through functional biomaterial design by Patrick S. Hume; Jing He; Kathryn Haskins; Kristi S. Anseth (3615-3625).
Dendritic cells play a key role in determining adaptive immunity, and there is growing interest in characterizing and manipulating the interactions between dendritic cells and biomaterial surfaces. Contact with several common biomaterials can induce the maturation of immature dendritic cells, but substrates that reduce dendritic cell maturation are of particular interest within the field of cell-based therapeutics where the goal is to reduce the immune response to cell-laden material carriers. In this study, we use a materials-based strategy to functionalize poly(ethylene glycol) hydrogels with immobilized immunosuppressive factors (TGF-β1 and IL-10) to reduce the maturation of immature dendritic cells. TGF-β1 and IL-10 are commonly employed as soluble factors to program dendritic cells in vitro, and we demonstrate that these proteins retain bioactivity towards dendritic cells when immobilized on hydrogel surfaces. Following stimulation with lipopolysaccharide (LPS) and/or cytokines, a dendritic cell line interacting with the surfaces of immunosuppressive hydrogels expressed reduced markers of maturation, including IL-12 and MHCII. The bioactivity of these immunomodulatory hydrogels was further confirmed with primary bone marrow-derived dendritic cells (BMDCs) isolated from non-obese diabetic (NOD) mice, as quantified by a decrease in activation markers and a significantly reduced capacity to activate T cells. Furthermore, by introducing a second signal to promote BMDC-material interactions combined with the presentation of tolerizing signals, the multifunctional PEG hydrogels were found to further increase signaling towards BMDCs, as evidenced by greater reductions in maturation markers.
Keywords: Immunomodulation; Hydrogel; Surface modification; Adhesion molecule; Photopolymerization;
Interactions of alginate-producing and -deficient Pseudomonas aeruginosa with zwitterionic polymers by Chun-Jen Huang; Luo Mi; Shaoyi Jiang (3626-3631).
In this work, we report a study of the interactions between bacteria and zwitterionic polymers using a long-range surface plasmon resonance (LR-SPR) sensor. The LR-SPR with an extended probing field allows one to perform in-situ monitoring of bacterial adhesion and to investigate bacteria–surface interactions under various conditions. Alginate-producing and -deficient Pseudomonas aeruginosa were used in order to study the role of capsular exopolysaccharide in bacterial adhesion onto a surface. Polycarboxybetaine polymers with one and two carbons in spaces between two oppositely charged moieties on polymer side chains (pCBAA-1 and pCBAA-2) were prepared in order to unveil the effects of material properties on surface resistance to bacterial adhesion. In addition, environmental factors (e.g., divalent cations) were investigated. This work demonstrates the role of polysaccharides beyond proteins in bacteria adhesion and the effective resistance of pCBAA-1 against bacterial adhesion.
Keywords: Bacterial adhesion; Long-range surface plasmon resonance; Zwitterionic polymers; Polysaccharide; Nonfouling properties;
Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss by Emmanuel Gibon; Zhenyu Yao; Allison J. Rao; Stefan Zwingenberger; Barbara Batke; Roberto Valladares; Robert L. Smith; Sandip Biswal; Sanjiv S. Gambhir; Stuart B. Goodman (3632-3638).
Particle-associated periprosthetic osteolysis remains a major issue in joint replacement. Ongoing bone loss resulting from wear particle-induced inflammation is accompanied by continued attempts at bone repair. Previously we showed that mesenchymal stem cells (MSCs) are recruited systemically to bone exposed to continuous infusion of ultra high molecular weight polyethylene (UHMWPE) particles. The chemokine–receptor axis that mediates this process is unknown. We tested two hypotheses: (1) the CCR1 receptor mediates the systemic recruitment of MSCs to UHMWPE particles and (2) recruited MSCs are able to differentiate into functional mature osteoblasts and decrease particle-associated bone loss. Nude mice were allocated randomly to four groups. UHMWPE particles were continuously infused into the femoral shaft using a micro-pump. Genetically modified murine wild type reporter MSCs were injected systemically via the left ventricle. Non-invasive imaging was used to assay MSC migration and bone mineral density. Bioluminescence and immunohistochemistry confirmed the chemotaxis of reporter cells and their differentiation into mature osteoblasts in the presence of infused particles. Injection of a CCR1 antagonist decreased reporter cell recruitment to the UHMWPE particle infusion site and increased osteolysis. CCR1 appears to be a critical receptor for chemotaxis of MSCs in the presence of UHMWPE particles. Interference with CCR1 exacerbates particle-induced bone loss.
Keywords: Arthroplasty; Wear debris; CCR1 receptor; Mesenchymal stem cells chemotaxis; Osteolysis;
Nanoparticle uptake and gene transfer efficiency for MSCs on chitosan and chitosan-hyaluronan substrates by Shan-hui Hsu; Tung-Tso Ho; Ting-Chen Tseng (3639-3650).
Nanoparticles (NPs) are usually surface modified to increase endocytosis for applications in cellular imaging and gene delivery. The influence of cell culture substrates on endocytosis remains relatively unexplored. This study investigated the substrate-mediated effects on the uptake of NPs by mesenchymal stem cells (MSCs). Two types of NPs were employed, negatively charged paramagnetic iron oxide (Fe3O4) NPs (∼5 nm) and bare plasmid DNA pTRE-Tight-DsRED2 (3.3 kb, ∼5 nm), each of which were poorly endocytosed by the adipose-derived MSCs grown on tissue culture polystyrene (TCPS). When cells were cultured on chitosan or hyaluronan-modified chitosan (chitosan-HA) membranes, significant increases (>5-fold) in the intracellular uptake of Fe3O4 NPs as well as transfectability of plasmid DNA were demonstrated. The enhancement in transgene expression was more pronounced than that using the transfection agent. The beneficial effects were not caused by elevated proliferation or a change in the differentiation state of interacting MSCs. On chitosan and chitosan-HA, cells moved fast and formed spheroids. The cytoskeletal arrangement associated with the up-regulated RhoA activity during spheroid formation may have accounted for the increased endocytosis. Using different inhibitors, the endocytosis pathways were further clarified. Both Fe3O4 NPs and plasmid DNA were taken up primarily by clathrin-mediated endocytosis on chitosan (∼50%). The caveolae-mediated endocytosis on chitosan-HA was more evident (∼30–40%) than that on chitosan (<25%). For plasmid DNA but not Fe3O4 NPs, macropinocytosis also occurred on both substrates. Chitosan and chitosan-HA as cell culture substrates may activate different endocytic pathways of MSCs to increase NP internalization or plasmid transfection. The substrate-mediated endocytosis described here may represent a new and potentially attractive approach to facilitate stem cell labeling or to improve gene delivery efficiency without altering cell viability and differentiation.
Keywords: Nanoparticles (NPs); Mesenchymal stem cells (MSCs); Endocytosis; Gene transfection; Chitosan;
The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation by Liliana S. Moreira Teixeira; Jeroen C.H. Leijten; Jos W.H. Wennink; Anindita G. Chatterjea; Jan Feijen; Clemens A. van Blitterswijk; Pieter J. Dijkstra; Marcel Karperien (3651-3661).
In situ gelating dextran-tyramine (Dex-TA) injectable hydrogels have previously shown promising features for cartilage repair. Yet, despite suitable mechanical properties, this system lacks intrinsic biological signals. In contrast, platelet lysate-derived hydrogels are rich in growth factors and anti-inflammatory cytokines, but mechanically unstable. We hypothesized that the advantages of these systems may be combined in one hydrogel, which can be easily translated into clinical settings. Platelet lysate was successfully incorporated into Dex-TA polymer solution prior to gelation. After enzymatic crosslinking, rheological and morphological evaluations were performed. Subsequently, the effect of platelet lysate on cell migration, adhesion, proliferation and multi-lineage differentiation was determined. Finally, we evaluated the integration potential of this gel onto osteoarthritis-affected cartilage. The mechanical properties and covalent attachment of Dex-TA to cartilage tissue during in situ gel formation were successfully combined with the advantages of platelet lysate, revealing the potential of this enhanced hydrogel as a cell-free approach. The addition of platelet lysate did not affect the mechanical properties and porosity of Dex-TA hydrogels. Furthermore, platelet lysate derived anabolic growth factors promoted proliferation and triggered chondrogenic differentiation of mesenchymal stromal cells.
Keywords: Hydrogel; Platelet lysate; In situ crosslinking; Chemotaxis; Cell proliferation; Cartilage tissue engineering;
Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues by Silvia Baiguera; Costantino Del Gaudio; Massimo O. Jaus; Leonardo Polizzi; Alessandro Gonfiotti; Camilla E. Comin; Alessandra Bianco; Domenico Ribatti; Doris A. Taylor; Paolo Macchiarini (3662-3672).
Bioengineered tissues created for transplant will be expected to survive and contribute to function over the lifetime of the individual. To evaluate potential intrinsic changes and degradation of the extracellular matrix of decellularized human tissue scaffolds, human decellularized tracheas were evaluated over a one year period in vitro. Human tracheas were decellularized and stored for one year in phosphate-buffered saline at 4 °C in the presence of antibiotics and anti-mycotics, and their structural, mechanical, and angiogenic properties compared to baseline values. Results showed that stored human decellularized tracheas were increasingly degraded resulting in a loss of extracellular matrix architecture – in particular of collagenous and elastic fiber structure –and decreased mechanical and angiogenic properties. The mechanical alterations of the extracellular matrix but not the deterioration and microstructure were not improved by using a natural cross-linking agent. These findings demonstrate that human decellularized tracheas, stored for one year in phosphate-buffered saline solution at 4 °C, would not meet the demands for a tissue engineering matrix and likely would not yield a suitable graft for lifelong implantation. The degradation phenomenon observed in vitro may be further enhanced in vivo, having clinical relevance for tissues that will be transplanted long-term and this should be carefully evaluated in pre-clinical settings.
Keywords: Angiogenesis; Cross-linking; Decellularized human trachea; Degradation; Long-term integrity; Mechanical properties;
The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney injury by Jiasheng Gao; Rongfu Liu; Jie Wu; Zhiqiang Liu; Junjie Li; Jin Zhou; Tong Hao; Yan Wang; Zhiyan Du; Cuimi Duan; Changyong Wang (3673-3681).
Transplantation of mesenchymal stem cells (MSCs) has been reported a great therapeutic potential for acute kidney injury (AKI). However, the therapeutic benefits are limited due to the low retention and survival of transplanted cells within target sites. In this study, thermosensitive chitosan chloride (CSCl) hydrogel was explored as injectable scaffold for adipose-derived MSCs (ADMSCs) delivery into ischemia/reperfusion (I/R) induced acute kidney injury (AKI). Thermosensitive CSCl hydrogels with/without ADMSCs were injected into the I/R site of rat AKI models. Dihydroethidium staining was used to detect the number of ROS in vivo. In order to track ADMSCs in vivo, ADMSCs were transfected with firefly luciferase and monomeric red fluorescent protein reporter genes (fluc-mrfp). The retention and survival of ADMSC were assessed using bioluminescence imaging, differentiation behaviors of ADMSCs were investigated using immunofluorescent and immunohistochemical staining. Proliferation and apoptosis of host renal cell in vivo were characterized by PCNA and TUNEL staining. Results suggested that CSCl hydrogels could improve the retention and survival of grafted ADMSCs, moreover, CSCl hydrogels could enhance the proliferation activity and reduce apoptosis of host renal cells. At 4 weeks, significant improvement of the renal function, microvessel density and tubular cell proliferation were observed in CSCl hydrogels with ADMSCs groups. Therefore, the application of thermosensitive CSCl hydrogel as scaffold for ADMSCs delivery into renal region could resolve the main obstacle of cell transplantation for acute kidney injury (AKI). Therefore, CSCl hydrogel is a potential cell carrier for treatment of AKI.
Keywords: Thermosensitive hydrogel; Chitosan; Adipose-derived mesenchymal stem cells; Acute kidney injury; Cell transplantation;
Augmented healing of critical-size calvarial defects by baculovirus-engineered MSCs that persistently express growth factors by Chin-Yu Lin; Yu-Han Chang; Chun-Yu Kao; Chia-Hsin Lu; Li-Yu Sung; Tzu-Chen Yen; Kun-Ju Lin; Yu-Chen Hu (3682-3692).
Repair of large calvarial bony defects remains clinically challenging because successful spontaneous calvarial re-ossification rarely occurs. Although bone marrow-derived mesenchymal stem cells (BMSCs) genetically engineered with baculovirus (BV) for transient expression of osteogenic/angiogenic factors hold promise for bone engineering, we hypothesized that calvarial bone healing necessitates prolonged growth factor expression. Therefore, we employed a hybrid BV vector system whereby one BV expressed FLP while the other harbored the BMP2 (or VEGF) cassette flanked by Frt sequences. Transduction of rabbit BMSCs with the FLP/Frt-based BV vector led to FLP-mediated episome formation, which not only extended the BMP2/VEGF expression beyond 28 days but augmented the BMSCs osteogenesis. After allotransplantation into rabbits, X-ray, PET/CT, μCT and histological analyses demonstrated that the sustained BMP2/VEGF expression remarkably ameliorated the angiogenesis and regeneration of critical-size (8 mm) calvarial defects, when compared with the group implanted with BMSCs transiently expressing BMP2/VEGF. The prolonged expression by BMSCs accelerated the bone remodeling and regenerated the bone through the natural intramembranous pathway, filling ≈83% of the area and ≈63% of the volume in 12 weeks. These data implicated the potential of the hybrid BV vector to engineer BMSCs for sustained BMP2/VEGF expression and the repair of critical-size calvarial defects.
Keywords: Baculovirus; Mesenchymal stem cells; Gene therapy; Calvarial bone defect; Tissue engineering; Sustained expression;
Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous Cell carcinoma-derived cancer stem cells by Wen-Liang Lo; Yueh Chien; Guang-Yuh Chiou; Ling-Ming Tseng; Han-Shui Hsu; Yuh-Lih Chang; Kai-Hsi Lu; Chian-Shiu Chien; Mong-Lien Wang; Yi-Wei Chen; Pin-I. Huang; Fang-Wei Hu; Cheng-Chia Yu; Pen-Yuan Chu; Shih-Hwa Chiou (3693-3709).
Metastasis is the major cause of high mortality in head and neck squamous cell carcinoma (HNSCC), in which HNSCC-derived cancer stem cells (CSCs) may be involved. Several reports have coupled non-viral gene delivery with RNA interference (RNAi) to target specific genes in cancer cells. However, the delivery efficiency of RNAi is limited and remained to be improved. Moreover, the therapeutic effect of non-viral gene delivery approaches on HNSCC-derived CSCs is still uncertain. In this study, we found that EZH2 and Oct4 are upregulated in HNSCC-derived ALDH1+/CD44+ CSC-like cells. Polyurethane-short branch PEI (PU-PEI)-based administration of double-stranded DNA (dsDNA) encoding small interfering RNA (siRNA) against EZH2 and Oct4 (siEZH2/siOct4) led to partial anti-cancer capacity and mild suppression of CSC-like properties. By pre-conjugation of nuclear localization signal (NLS) to siRNA-expressing dsDNA, the anti-cancer efficacy was enhanced due to elevated nuclear delivery. Notably, the NLS-preconjugated siEZH2/siOct4 constructs remarkably repressed epithelial-mesenchymal transdifferentiation (EMT) and radioresistance in ALDH1+/CD44+ CSC-like cells, in which Wnt5A and CyclinD1 may be involved respectively. We furthermore demonstrated that this improved method was capable of reducing tumor growth and metastasis in vivo. Our findings may provide a feasible non-viral gene delivery method to eradicate HNSCC-derived CSCs and improve HNSCC therapy.
Keywords: Small interfering RNA; Head and neck squamous cell carcinoma; EZH2; Oct4; Nuclear localization signal;
Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging by Wen Gao; Lifei Ji; Lu Li; Guanwei Cui; Kehua Xu; Ping Li; Bo Tang (3710-3718).
We demonstrate bifunctional combined Au-Fe2O3 nanoparticles (NPs) for selectively induction of apoptosis in cancer cells and real-time imaging. The as-prepared Au-Fe2O3 NPs combine the merits of both Au and γ-Fe2O3 NPs, maintaining excellent fluorescence quenching property and catalytic activity. Conjugated with αⅤβ3 integrin-targeting peptide (RGD) and fluorescein isothiocyanate (FITC)-labeled capsase-3 recognition sequence (DEVD) on the Au surface, the resulting RGD/FITC–DEVD–Au-Fe2O3 NPs bind preferentially to integrin αⅤβ3-rich human liver cancer cells (HepG2), sequentially initiate catalytic formation of hydroxyl radicals (•OH) and enable the real-time monitoring of•OH-induced caspase-3-dependent apoptosis in these cancer cells. Furthermore, the catalytic activity of RGD/FITC–DEVD–Au-Fe2O3 NPs is much higher than that of individual γ-Fe2O3 NPs due to the polarization effect at the Au-Fe2O3 interface. Such bifunctional Au-Fe2O3 NPs exhibit simultaneous targeting, therapeutic and imaging functions and are therefore promising for future therapeutic applications in cancer.
Keywords: Au-Fe2O3; Combined nanoparticles; Catalytic activity; Hydroxyl radical; Apoptosis; Real-time imaging;
Cancer stem cell labeling using poly(l-lysine)-modified iron oxide nanoparticles by Xueqin Wang; Fang Wei; Ajing Liu; Lei Wang; Jian-Chun Wang; Li Ren; Wenming Liu; Qin Tu; Li Li; Jinyi Wang (3719-3732).
Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, proliferation, multi-differentiation, cell cycle, and apoptosis, remains elusive. The present study sought to explore the potential effects on biological behavior when CSCs are labeled with superparamagnetic iron oxide (SPIO) nanoparticles in vitro. The glioblastoma CSCs derived from U251 glioblastoma multiforme were labeled with poly(l-lysine) (PLL)-modified γ-Fe2O3 nanoparticles. The iron uptake of glioblastoma CSCs was confirmed through prussian blue staining, and was further quantified using atomic absorption spectrometry. The cellular viability of the SPIO-labeled glioblastoma CSCs was assessed using a fluorescein diacetate and propidium iodide double-staining protocol. The expressed specific markers and multi-differentiation of SPIO-labeled glioblastoma CSCs were comparatively assessed by immunocytochemistry and semi-quantitative RT-PCR. The effects of magnetic labeling on cell cycle and apoptosis rate of glioblastoma CSCs and their differentiated progenies were assayed using a flow cytometer. The results demonstrated that the cell viability and proliferation capacity of glioblastoma CSCs and their differentiated progenies were not affected by SPIO labeling compared with their unlabeled counterparts. Moreover, the magnetically labeled CSCs displayed an intact multi-differentiation potential, and could be sub-cultured to form new tumor spheres, which indicates the CSCs capacity for self-renewal. In addition, cell cycle distribution, apoptosis rate of the magnetically labeled glioblastoma CSCs, and their differentiated progenies were not impaired. Therefore, the SPIO-labeled CSCs could be a feasible approach in conducting further functional analysis of targeted CSCs.
Keywords: Cancer stem cell; Cell labeling; Iron oxide nanoparticle; Multi-differentiation; Self-renewal;
Cubic sub-20 nm NaLuF4-based upconversion nanophosphors for high-contrast bioimaging in different animal species by Tianshe Yang; Yun Sun; Qian Liu; Wei Feng; Pengyuan Yang; Fuyou Li (3733-3742).
A new upconversion luminescence (UCL) nanophosphors based on host matrix of cubic NaLuF4 with bright luminescence have been synthesized by a solvothermal method, facilitate the nanocrystals potential candidates for imaging in vivo, especially large-animals. The sub-20 nm NaLuF4 co-doped Yb3+ and Er3+ (Tm3+) showed about 10-fold stronger UCL emission than that of corresponding hexagonal NaYF4-based nanocrystals with a 20 nm diameter. Near-infrared to near-infrared (NIR-to-NIR) UCL emission of PAA-coated NaLuF4:20%Yb,1%Tm (PAA-LuTm) can penetrate >1.5 cm tissue of pork with high contrast. Based on super-strong UCL emission and deep penetration, PAA-LuTm as optical bioprobe has been demonstrated by in vivo UCL imaging of a normal black mouse, even rabbit with excellent signal-to-noise ratio. Furthermore, such cubic NaLuF4-based nanophosphor was applied in lymph node imaging of live Kunming mouse with rich white fur.
Keywords: Upconversion nanophosphors; NaLuF4; Large-animal imaging; Upconversion luminescence imaging;
A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X by Hayato Matsui; Fuminori Sakurai; Kazufumi Katayama; Tomoko Yamaguchi; Sayuri Okamoto; Kohdai Takahira; Masashi Tachibana; Shinsaku Nakagawa; Hiroyuki Mizuguchi (3743-3755).
We previously developed a hexon-specific PEGylated adenovirus (Ad) vector by utilizing avidin-biotin interaction. However, the Ad vector was aggregated due to the multiple interactions between avidin and biotin, resulting in a reduction in the transduction efficiencies in the organs following systemic administration. In this study, we developed a new method for hexon-specific PEGylation by mixing Ad vectors with PEGylated blood coagulation factor X (FX) (PEG-FX). FX specifically binds to the hexon protein, suggesting that FX serves as an adaptor molecule for hexon-specific modification. Intravenous administration of the PEG-FX-associated Ad (PEG-FX-Ad) vector into conventional mice resulted in prolonged blood retention. However, the transduction efficiencies in the liver were not reduced by PEG-FX. On the other hand, in the warfarinized mice, the PEG-FX-Ad vectors exhibited a significant reduction in the liver transduction. In addition, incubation of the PEG-FX-Ad vector with unmodified FX resulted in dissociation of PEG-FX from the Ad vector, indicating that a substitution of PEG-FX with endogenous FX occurs in the blood following administration. This study demonstrates that FX can be used as an adaptor molecule for hexon-specific modification; however, modified FX might be substituted with endogenous FX in the blood.
Keywords: Adenovirus vector; Blood coagulation factor X; PEGylation; Hexon;
Stability of influenza vaccine coated onto microneedles by Hyo-Jick Choi; Dae-Goon Yoo; Brian J. Bondy; Fu-Shi Quan; Richard W. Compans; Sang-Moo Kang; Mark R. Prausnitz (3756-3769).
A microneedle patch coated with vaccine simplifies vaccination by using a patch-based delivery method and targets vaccination to the skin for superior immunogenicity compared to intramuscular injection. Previous studies of microneedles have demonstrated effective vaccination using freshly prepared microneedles, but the issue of long-term vaccine stability has received only limited attention. Here, we studied the long-term stability of microneedles coated with whole inactivated influenza vaccine guided by the hypothesis that crystallization and phase separation of the microneedle coating matrix damages influenza vaccine coated onto microneedles. In vitro studies showed that the vaccine lost stability as measured by hemagglutination activity in proportion to the degree of coating matrix crystallization and phase separation. Transmission electron microscopy similarly showed damaged morphology of the inactivated virus vaccine associated with crystallization. In vivo assessment of immune response and protective efficacy in mice further showed reduced vaccine immunogenicity after influenza vaccination using microneedles with crystallized or phase-separated coatings. This work shows that crystallization and phase separation of the dried coating matrix are important factors affecting long-term stability of influenza vaccine-coated microneedles.
Keywords: Coating formulation; Crystallization; Influenza vaccine; Microneedle patch; Phase separation; Vaccine stability;
Ruthenium-based complex nanocarriers for cancer therapy by Gaetano Mangiapia; Gerardino D'Errico; Luca Simeone; Carlo Irace; Aurel Radulescu; Antonio Di Pascale; Alfredo Colonna; Daniela Montesarchio; Luigi Paduano (3770-3782).
A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
Keywords: Ruthenium-based complexes; Antineoplastic agents; Nanoaggregates; Anti-proliferative activity;


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Joni Mitchell, River (1971)
A jolly festive ditty this is not. But Mitchell's River manages to sum up the feeling of escapism which can descend along with the annual Christmas paraphernalia – especially when there is nobody waiting under the mistletoe. It's worth listening to for the interpretation of Jingle Bells alone. Alice Vincent

subset: commoncrawl


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Slow Cooker Chicken Tortilla Soup
The perfect chicken tortilla soup recipe. An easy and flavorful chicken soup made in the slow cooker, topped off with shredded cheese and seasoned tortilla strips.
Fall is an exciting time. For starters it's my favorite season, not just for the juicy fresh locally grown apples and all of the amazing seasonal recipes but also for all of the changes. The leaves start to turn and the weather gets cooler. It means bundling up in cozy clothes, snuggling under a blanket and sipping on a hot drink.
Have you ever noticed all of the delightful smells that come with Fall? There's a fresh crispness to the air. And let's not forget it's nearly fire season… the good and cozy kind.
But Fall brings many other kinds of changes. It kicks off the busy season. Class is back in session, for many…after school sports and activities are in full swing. Vacations and days of lounging around are but a memory now. And to make matters worse, the days are getting shorter. Less time and less light to get everything done.
To make life easier, it's time to pull out the slow cooker. I happily use mine year round, but it's especially handy and well loved in the busier and cooler months. From stews to chowders and soups, even to slow cooked meet, slow cookers are super handy to have. Toss your ingredients in before you head off to work, running errands or just hanging out at home. Hours later you'll have a delicious meal with minimal effort. It's an incredibly easy way to make a large batch of food to enjoy for dinner, a weeks worth of meals or to stock up your freezer!
I've been wanting to make a tortilla soup since last year, I just never got around to making it. I truly wish I hadn't waited so long. It was incredible. Full of flavor, just the right ratio of liquid to solids and the perfect hint of spice. I honestly wanted to use homemade tortilla strips and I tried to make some but didn't love the results so store bought strips won out. I love the handiness of this prepackaged item as you can snack on them and have them ready for whenever you heat up a bowl of this soup. No slaving over the stove to crisp up fresh tortilla strips, just open the bag and grab a bunch!
If you're looking for other slow cooker ideas, be sure to check out this slow cooker roundup from last year and a few new recipes, like slow cooker mini meatball minestrone soup and slow cooker lobster chowder!
Homemade seasoned tortilla strips are a perfect addition to this recipe!
Yield: Serves 8-10
Cook Time: 4 hours
Slow Cooker Chicken Tortilla Soup
An easy and flavorful chicken soup made in the slow cooker, topped off with shredded cheese and seasoned tortilla strips.
- 1lb chicken breast, trimmed
- 15oz can sweet whole corn kernels, drained
- 15oz can diced tomatoes, drained
- 5C chicken stock
- 3/4C onion, chopped
- 3/4C green bell pepper, chopped
- 1 serrano pepper, minced
- 2 cloves garlic, minced
- 1/4 tsp chili powder
- 1 1/2 tsp salt, divided
- 1 tsp ground pepper, divided
- Monterey Jack cheese, shredded
- Seasoned tortilla strips
- To your slow cooker add first 9 ingredients plus 1 tsp salt and 3/4 tsp ground pepper. Cook on high for 4 hours or low for 8 hours.
- Prior to serving, remove chicken breasts. Transfer chicken to the bowl of a stand mixer fitted with a paddle attachment for easy shredding. Alternately you may shred chicken by hand. Season chicken with 1/2 tsp salt and 1/4 tsp pepper. Return shredded seasoned chicken to slow cooker bowl. Stir gently.
- If serving immediately, divide among bowls. Top off with a generous helping of shredded cheese and seasoned tortilla strips. Soup may be stored in the fridge for up to several days. If freezing, label containers well with soup name and date.
Baked by Rachel original
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276 Responses to "Slow Cooker Chicken Tortilla Soup"
Best crock pot recipe ever! Have shared with many. Thanks!
This soup was so good! I made it last week and plan to make it this week for our company.
I made this on Sunday for lunches this week at work! Great recipe I loved it!
This might seem like a silly comment, but I love how you put your website address on the rim of the bowl in your picture, pure genius! And, of course, the recipe looks delicious. ;)
Does the chicken need to be cooked before putting in the crock pot? I'm new to this and don't want to get my family sick . Thanks!
I've been making this a couple of years since I found it on Pinterest and I LOVE this soup! It's amazing just like the recipe but I love adding things in and substituting ingredients to fit my family's tastes. My favorite thing to do is add a can of black beans and/or diced black olives, then about 5 minutes before serving I cut up a block of cream cheese and stir it a few times until it's all melted. My kids like things very mild so I usually substitute the tomatoes and peppers for a can of mild rotel. I just love how endless the possibilities are when making it and it still turns out fantastic every time. This is our absolute favorite soup recipe! Thank you so much for posting it!
Can I combine all ingredients and freeze before cooking? Want to make this for a friend but want her to make it when she wants it… Not because it's going bad in her refrigerator… Thanks!
What size crock-pot did you use for this? Mine tends to be smaller than most recipes call for, I don't want to overflow. Thanks!
Wondered if I could use ground chicken breast?
Amazing, yet SO SIMPLE! I made this in my crock pot while on hold with a phone call! I have 2 teenage boys and a husband that all LOVED this. I substituted the green peppers for chopped green chilies and added cumin and cilantro to the 'first 9 ingredients'. I also used organic chicken thighs with very very little fat on them and it added some great flavor to the broth. I garnished with lime squeezed in the bowl as it is served (really adds a punch to the flavor)- do not add lime before you serve or it will get bitter in the soup as it cooks. My oldest son wants me to keep this recipe for him when he moves out so he can make it on his own. Huge compliment to say the least…..
Recipe sounds delicious! I can't eat corn. Can you suggest something to substitute?
This looks great and I love that there's no 'cream of' soups involved. Pinned!
Made this yesterday. Will be making often. Use Rotisserie chicken for quick dinner. Also, because it is in season, I used fresh corn.
Amazing flavor. One of the best recipes on Pinterest. A must try.
Delicious and easy soup. I served with tortilla chips and cheese. Yummy!
Silly question, when you say green pepper.. do you mean green bell pepper?


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Product Information
BasAcc Cable/ Charger Adapter/ Silicone Case for Apple® iPod shuffle 4
This is a BasAcc 4-piece set for Apple® iPod Shuffle 4. Keep your iPod shuffle safe and protected in style with this accessory set. Compatibility: Apple® iPod Shuffle 4 Includes: Cable Silicone skin case Car charger adapter Travel charger adapter Cable Portable and tangle free Connector: 3.5-mm diameter stereo plug Color: White Length: 5-inches (can be extended up to 32.5-inches) Silicone skin case Delivers instant all around protection from scratches Allows easy access to all functions Resists dirt and stains Material: Silicone Color: Black Size: Perfect fit Car charger adapter Note: Needs to pair with a USB charging cable Compact and lightweight Patented circuit board protects against short circuits White high-impact plastic LED power indicator Fits into any 12V accessory outlet or car lighter jack Travel charger adapter Note: Needs to pair with a USB charging cable World traveler (100-240V). Automatically adjusts to all voltages and frequencies in the U.S., Europe, and Asia LED charging indicator shows charging status Patented circuit board protects against short circuits Color: White All rights reserved. All trade names are registered trademarks of respective manufacturers listed. Apple®, iPhone®, iPad®, iPod® are registered trademarks of Apple®, Inc. Apple® does not endorse use of these products. California PROPOSITION 65 WARNING: This product may contain one or more chemicals known to the State of California to cause cancer, birth defects, and/or other reproductive harm.
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The Weller Pottery of Zanesville was one of the most prolific of the Ohio Potteries, creating lines ranging from high-end art ware to functional commercial ware.
Lavonia, a middle period line easily recognized by its pastel matte glaze of pink and turquoise, was produced from the early 1920's until 1928, and can be rather hard to come by today. This lovely Weller Lavonia tapered, hexagonal vase circa 1925 features a gently flared rim and base, with a gorgeous glaze effect of palest pink blending to turquoise.
Condition is excellent, free from chipping, cracking, or restoration, with minor surface marks and production mold flaws present.
Marked at the base with die-impressed "WELLER".
H 8.25", rim 3.25", base 2.75".
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Funny name, serious pottery!


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Reviewed here:
My Best Buy had it today. Austin TX
Can someone give their own review?
I want to rent this game before I buy it but it seems like nobody has it in.
I'm just about to give it a try, and I'll report back my first impressions.
Ok, I went throught the tutorial, and played an 18 hole tournament (to which I won ) but here's my first impression.
The swing controls are a little bit different than wii sports golf. First off, when you take a swing in wii sports golf you hold down A, then take your full swing. In SSG you take a back swing, then basically you have to hold your position to hit A, then follow through. At first I thought it was a bit weird (and not as 'realistic' as wii sports) but you do get to fine tune the power in your backswing before following through. The follow through is important, as it has to be brisk and high in order to get your best shot. Putting, well putting is a bit unrealistic. The swing is somewhat jittery and unresponsive at first, but you do get used to the movements. I guess if you compared the putting stroke to real life golf, it's nothing close, but this is a video game.
After getting used to the controls (about 10 minutes of practice) it was starting to get fun. There are some cool features. The overhead camera view takes advantage of the wiimote with zoom controls that are managed by moving closer and further from the TV. Also, on the putting green, the use of dots on the putting grid to determine the slopes is unique and rather neat.
Of course, as I play more and unlock all the fun stuff the game could get to be even more fun, but at this point I've enjoyed my first 18 holes. I know some of the courses are very fantasy-like and far from realistic, but I've played enough Tiger Woods that this could be a welcome change.
Last edited by pianodood; 12-15-2006 at 01:24 PM.
"Ball in a Cup!"
Please PM me if you add me to your wii address book, thanks!


text:
This content has been marked as final. Show 3 replies
Re: Netflix on the Nook TabletTnTexas Nov 22, 2011 11:05 AM (in response to NookTabUser)
I'm assuming you're talking about the app supplied by the Tablet. In that case, you got 31/2 lines of movies showing on the screen. The third one is titled "Instant Queue". That's the line you're looking for. It appears you'll have to make any changes to it via the actual webpage, but the instant-view movies you've already chosen are listed there.
Re: Netflix on the Nook Tabletrobotecture Nov 22, 2011 10:55 PM (in response to TnTexas)Same goes for the Netflix apps on any Mobile device... On the iPhone etc... It is a Netflix player rather than a queue editor... For the Nook Color there was a third party app called "Netflix Queue Manager" which was like what you are looking for... But that doesn't work on the Nook Tablet for some reason... But you cN of course on the nook tablet search for any movie and play it...
Re: Netflix on the Nook TabletSpaceCoyoteSyas Dec 29, 2011 1:32 PM (in response to robotecture)
I am picking up my NT tonight, but I believe you should be able to edit the queue through the web browser, then use the app for optimal playback!


text:
Hey Penguins! :)
Recently I have been looking for some Free Club Penguin icons and haven't been able to find any! So I thought I would make a few myself for anyone to use! :) These would make great avatars for twitter, Message boards or even a Fun thing to place on your Sidebar! Here are some I have came up with! I hope you enjoy them....
I love this one. Show your puffle sprit with this cute icon!
Take an adventure Icon.(With a Boy penguin) :D
Take an Adventure Icon.(With a Girl Penguin) :)
Show you're Blue Team Spirt with this Icon! :)
Show your Red team Sprit with this icon! :D
Show your Green Team Sprit with this icon! :)
Show your Yellow Team Sprit with this icon! :)
Tell everyone Happy thanksgiving with this Silly Icon! (With Boy penguin)
Tell everyone Happy thanksgiving with this Silly Icon! (With Girl penguin)
Rock on Music Note Icon. :)
I hope you enjoy all of the Icons! :) Please feel free to take any of these Icons! You can Right Click on your mouse and click Save Picture As. Save it in your folder and then your ready to go! Paste it anywhere you want! I mainly use these Icons for my Twitter page but if you want to put them anywhere else....Please do so! :) I will be putting New Icons every-once in awhile so make sure to come back. So you can check those out. Also if you have an idea for an icon that I can make. Make sure to comment below. I am always excited to try new things!
Enjoy! :D
~Hope Aka Clubpenguinfan~


text:
First Assistant Harris County Attorney Terry O'Rourke will step down from his post at year's end, to be replaced by Robert Soard, who has worked as the office's chief of staff for the last three years, according to an email County Attorney Vince Ryan sent Wednesday to his employees.
"I very much appreciate the passion and vision Terry has shown during his tenure as First Assistant and I thank him for his service," Ryan wrote, adding his right-hand man will "spend more time on academic and personal interests."O'Rourke still will work 32 hours per week as Special Counsel, focusing on "major projects." He will make $74.72 an hour, his current rate (the equivalent of $124,334 a year).
"I am writing a book about pollution prosecution and my experience in politics, and it goes backwards in time to when I was an assistant attorney general for the state of Texas, and tracking the progress that we've made in environmental litigation," O'Rourke said. "And I'll be able to spend more time on the prosecution of big cases."
O'Rourke said these include pending cases against the owners of leaking underground fuel storage tanks, against Treasures strip club, against companies who own properties that contributed to the contamination of the San Jacinto River and human trafficking cases.
The 58-year-old Soard, who has worked in the County Attorney's office for about 10 years, prior to Ryan's 2009 inauguration, "will help us build on our successes as we continue to become the best public law office in the United States," Ryan wrote.
O'Rourke, who turned 66 Tuesday, joined the office after Ryan's election in 2008, having previously served as an assistant county attorney from 1986 to 1996. O'Rourke also spent time as a page and a staff member in the U.S. Congress, as a staffer in the Texas Legislature, in the state Attorney General's office, and in the administration of President Jimmy Carter.
O'Rourke, a Democrat, had several unsuccessful runs for public office, including Texas Railroad Commission, a District Court judgeship, Harris County Attorney, and Harris County Judge.
The eccentric, verbose O'Rourke often wears green ties to honor his Irish heritage, is known to Ryan and others as "El Tigre," and prefers pacing about the County Attorney's office in his socks.
"If you had to say one thing about Terry O'Rourke, it's that I love public service, the fun, the joy of it, too, not just the hard work," he said.


text:
Best Original Score
Jonny Greenwood — "The Master"
Dan Romer & Benh Zeitlin — "Beasts of the Southern Wild"
John Williams — "Lincoln"
Mychael Danna — "Life of Pi"
Nick Cave — "Lawless" and "West of Memphis"
Follow our news and updates on Twitter and our relationship status on Facebook. Or send us a telegram.
Reverb Managing Editor Matt Miller has a Twitter account that he uses fairly often, but not often enough to be annoying.
Pages: 1 2


text:
Welcome to WebmasterWorld Guest from 18.104.22.168
Forum Moderators: martinibuster
Generally, there's nothing wrong with different links with different text anchors as and when you can control them - but obviously there are advantages with trying to get links across more domains and IP ranges, rather than getting more links on a single page.
joined:May 30, 2005
votes: 0
I do not know the right answer but let's build an example.
1. On page1 there are only link1 pointing to site1
I think that (almost) all page1 influence goes to site1
2. On page1 there are 2 links, link1 pointing to site1 and link2 pointing to site2. In that case the page1 influence should go to site1 and site2 divided in equal parts (almost half for each site)
3. On page1 there are 3 links, link1 and link2 pointing to site1 and link3 pointing to site2. In that case, in my opinion, almost 2/3 from page1 potential goes to site1 and almost 1/3 to site2.
Is it true? Does anybody know?
Although I do not have a direct experience with this scenario, I would never provide 2 links to the same URL (not site) from the same page; BUT I would surely provide 2 links with different anchor texts on the same page to 2 different URLs of another website.
I think it's much safer to proceed like this and may give you even better SE performance.
Best luck with your case and please keep us informed how it's going.
But, multiple links on the same page to a common page using different anchor text can work very well in my experience.
It's a great way to attract the attention of folks who might visit the page for different reasons, or who might get a better idea of what they'll find on the page.
I would't overdo it, but 2 - 3 links can work well for directing traffic.


text:
Night Paintings by Paul Benney
4 October – 9 December 2012
Daily 10.00-18.00, Until 21.00 on Thu 29 Nov & 6 Dec
Free admission
Celebrated British artist Paul Benney, a resident artist at Somerset House, brings his Night Paintings to the hidden passageways underneath its fountain courtyard for the first exhibition of its kind in this unique space. Curated by Flora Fairbairn, the exhibition includes more than 25 paintings, comprised of past and new works created over the duration of the artist's tenure as a resident artist. The exhibition is the first exhibition of paintings to be held in our Deadhouse, a series of hidden, atmospheric chambers which contain the gravestones of 17th century palace retainers beneath The Edmond J. Safra Fountain Court.
Night Paintings reveals Benney's deep interest in the intangible world we see beyond the mirror. His allegorical paintings are inspired by a long tradition of artists including Goya, Rembrandt and Velázquez, whose art, whether allegorical, religious or historical, flourished alongside their works of portraiture, the one informing, shaping and redefining the other. The exhibition sees Benney return to painting the shamanistic presences which have long preoccupied him, introducing us to people who dwell in mysterious hinterlands, who belong in places that lie somewhere between the earthbound and the transcendent. He paints figures which, while their meanings can never quite be fixed, embody some sense of our spiritual quest.
Paul Benney Spotlight Tour
Tuesday 4 December at 13.15
Artist Paul Benney offers an insight into the ideas and inspirations behind his new exhibition Night Paintings at Somerset House. Limited spaces on the tours are bookable at the Seamen's Hall Info Desk from 12.45. Visit Paul Benney's website here


text:
[email]email@example.com[/email] wrote:[color=blue]
> On Oct 2, 1:34 pm, Jean-David Beyer <jeandav...@verizon.net> wrote:[color=green]
>> I do not understand the distinction you are making between a "called" child
>> process and a "forked" process, since they all get started by one of the
>> fork(2) functions.[/color]
> I gather what he describes as called is "exec"ed, where a new process
> replaced the currently running one (after a fork in the case of
> xinetd).
> Steve[/color]
Probably thats how the code looks at source, yes.


text:
Concerned residents speak out at a planning board meeting, asking that a developer not be granted a zoning change for a new development.
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Local roundup: Montgomery boys soccer wins
September 20, 2013
Marcus Bartlett and Jacob Umpstead scored as Montgomery beat St. John Neumann, 2-0, on Thursday in boys soccer. Shikellamy's Seth Burke scored in the 47th minute in a 1-0 win over Williamsport....
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text: Jig-N-Coat™ is a powder coating for jig heads, spoons and metal parts. Applied by heating the metal part and dipping it into the powder, Jig-N-Coat™ results in a colorful, glossy coating that is very durable. If you're looking for a powder coat, then look no further. The Spike-It™ brand is simply the best! When it comes to quality, choose a name you can trust...SPIKE-IT™! | 2 oz.


text:
Free Algebra
Systems of Linear Equations and Problem Solving
Solving Quadratic Equations
Solve Absolute Value Inequalities
Solving Quadratic Equations
Solving Quadratic Inequalities
Solving Systems of Equations Row Reduction
Solving Systems of Linear Equations by Graphing
Solving Quadratic Equations
Solving Systems of Linear Equations
Solving Linear Equations - Part II
Solving Equations I
Summative Assessment of Problem-solving and Skills Outcomes
Math-Problem Solving:Long Division Face
Solving Linear Equations
Systems of Linear Equations in Two Variables
Solving a System of Linear Equations by Graphing
Ti-89 Solving Simultaneous Equations
Systems of Linear Equations in Three Variables and Matrix Operations
Solving Rational Equations
Solving Quadratic Equations by Factoring
Solving Quadratic Equations
Solving Systems of Linear Equations
Systems of Equations in Two Variables
Solving Quadratic Equations
Solving Exponential and Logarithmic Equations
Solving Systems of Linear Equations
Solving Quadratic Equations
Math Logic & Problem Solving Honors
Solving Quadratic Equations by Factoring
Solving Literal Equations and Formulas
Solving Quadratic Equations by Completing the Square
Solving Exponential and Logarithmic Equations
Solving Equations with Fractions
Solving Equations
Solving Linear Equations
Solving Linear Equations in One Variable
Solving Linear Equations
casio calculators for solving equations
Related topics:
how to transform standard form into vertex form
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prime factorization worksheets
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Registered: 05.09.2007
From: Singapore
Posted: Friday 29th of Dec 13:38
Hey, A couple of days back I started working on my mathematics assignment on the topic College Algebra. I am currently not able to finish the same since I am not familiar with the fundamentals of inverse matrices, percentages and factoring expressions. Would it be possible for anyone to help me with this?
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Registered: 17.03.2002
From: Norway
Posted: Saturday 30th of Dec 18:51
Algebrator is one of the most powerful resources that can render help to people like you. When I was a novice , I took help from Algebrator. Algebrator offers all the principles of Algebra 2. Rather than using the Algebrator as a step-by-step guide to work out all your math assignments, you can use it as a coach that can offer the basics of radical equations, y-intercept and graphing function. Once you understand the principles, you can go ahead and solve any tough problem on Algebra 1 in no time .
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Registered: 08.07.2001
Posted: Sunday 31st of Dec 17:26
It is good to know that you wish to improve your math and are taking efforts to do so. I think you should try Algebrator. This is not exactly a tutoring software but it offers solutions to math problems in a very descriptive manner. And the best thing about this software product is that it is very user friendly. There are a lot of examples given under various topics which are quite useful to learn the subject. Try it and wish you good luck with math.
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Registered: 19.03.2007
From: Canada
Posted: Tuesday 02nd of Jan 10:08
Friends , Thanks a lot for the guidance that you have given . I just had a look at the Algebrator available at:
. The interesting part that I liked was the money back guarantee that they are extending there. I went ahead and purchased Algebrator. It is really user friendly and turns up to be a remarkable tool for Remedial Algebra.
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Registered: 25.09.2001
From: Kµlt °ƒ Ø, working on my time machine
Posted: Thursday 04th of Jan 09:38
Algebrator is a very remarkable product and is surely worth a try. You will find quite a few exciting stuff there. I use it as reference software for my math problems and can say that it has made learning math much more enjoyable.
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Registered: 27.09.2001
From: Germany
Posted: Thursday 04th of Jan 10:58
The software is a piece of cake. Just give it 15 minutes and you will be a professional at it. You can find the software here,
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All Right Reserved. Copyright 2005-2016


text:
Nick Grant was 3-for-3 with two runs and two RBI and threw six strong innings as Newton defeated Elmwood Park, 11-1, in the first round of the North Jersey, Section 1, Group 2 tournament in Newton.
Grant (5-0) struck out five, allowing one run, four hits and three walks for Newton. Ben Cramer and Anthony Morro were each 2-for-4 with three runs and an RBI. Jon Bernotas, Brady Castle and Joe Maker each added two RBI. Elmwood Park's Sean Volk was 3-for-4.


text:
The Added Value of Fulfillment Services
- Sponsored by EFI
During this one-hour event, a panel of experts will provide graphic arts executives with insight, advice and guidance relative to implementing Fulfillment Services for the commercial and in-plant printing industry. In an interactive round table format, facilitated by Sherburne, panelists will answer prepared questions and questions submitted by the audience about the lessons they have learned in implementing fulfillment services and what they plan for the future.
Webinar Details
When: Anytime - webinar archive playback is available on demand
Where: Anywhere - all that is required is an Internet connection and a Web browser that supports Flash.
What: The Added Value of Fulfillment Services Webinar
Log in or Become a member to Attend this Free Webinar
Our webinars are provided to members free of charge thanks to support from our sponsors. Basic Membership is free. Log In or Become a Member, doing so is simple and free
If you have any questions about attending or viewing live and archived webinars, please contact us.
For details on Webinar sponsorship opportunities, please contact our sales team.


text:
27 February 2012 to 04 March 2012
Showing 3 events
Free Guided Tour: Hidden Spaces and History
03 March 2012
Somerset House
Discover evidence of Tudor intrigue and Georgian Enlightenment, of scientific curiosity, naval power and extravagant entertainments.
Free Family Workshop: Marbling Marvels
03 March 2012
Learning Centre
Discover the craft of paper marbling, and create luxurious decorative papers for your books or gifts.
Mini Make Believe: Mad March Hares!
04 March 2012
Learning Centre
Spring is here, and everyone is hopping skipping and jumping, especially as it's a leap year. Join us for songs, stories and bouncy hats.


text:
About Us
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eWicca Full Description
All-in-one pagan and wicca software to learn and perform magic rituals
Full Description
1, August 2010
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$97.77 -
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Product Info
All in one pagan and wicca software to learn and perform magick rituals and cast wicca spells, to develop own wicca rituals: candle magick, knot magic, ritual magic, voodoo, charms, etc. Audio and visual stimulations (subliminal messages, binaural beats) to increase effectiveness of magic ritual and utilize maximum of your supernatural power. Comprehensive wicca guide and free utilities to select the best time for ritual depending on moon phase and biorhythm cycle, to calculate word or date numeric values, to plan rituals and record own development;I include words of power and customer name into eWicca source code to personalize program and ensure maximum effectiveness for your rituals.Specially selected wicca (witchcraft, magick) rituals, spells for love, health, prosperity, relationships, etc.; All required ceremonies to prepare for magick rituals: mind preparation, energy, space consecration, goal visualization, salt cleansing, empowering potion, etc;
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if you have questions or issues regarding this product.
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license key or activation code online from ShareIt! using one of these payment methods: Credit Card, PayPal, Bank/Wire Transfer, Check/Money Order, Open Invoice (European). The order process is protected via secure connection using VeriSign Secure Socket Layer (SSL) technology.
Using a crack or a pirated serial or key generator to activate eWicca full version without buying a license key is against the law.
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Potsdam, NY - 14th February 2007 [Valentines Day]Leading ASP spellchecking component ASPSpellCheck has not been ported to the .NetFramework. This advanced Intranet and Website spellchecking software is not used bygovernments and corporations the world over.The result is ASPNetSpell - a web control for Asp.Net 1.x and 2.0. It can beinstalled and integrated into most applications in a few...
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Harbinger Knowledge Products today announced a significantmajor release 4.5 of Raptivity. The significant highlights of this release are theease and flexibility of deployment in a multi-user corporate environment and moreconvenient integration with other tools. This release also comes with a Spellchecker add-on. Raptivity has bagged Platinum and Gold awards for highest user satisfaction....
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Script Spell Check - At Last, after 10 yearshttp://www.javascriptspel lcheck.com finally offers the "missing " JavaScript SpellCheck Functions fo developers - including:The Software Extends your Website with : - Spell Check Website Forms and Variables - Ajax Spell Checking - Real-Time Spelling Valdiation. JavaScriptSpellCheck is a comprehensive spell checking component for...
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text:
Appel Farm, which oversees a converted 176-acre farm in Salem County as a music and arts education camp, as well as a 200-seat theater in Elmer, could sign a deal next week with the nonprofit Landis Theater Foundation, which would retain ownership.
"Appel would begin presenting the next season starting in October, but the work for us would begin almost immediately — booking shows and getting more exposure for the theater," said Appel Executive Director Mark Packer on Monday. "(If the deal goes through), Appel will act as manager, and do booking, the front, the back — everything."
That means Appel would assume control and responsibility of all of the Landis Theater incomes and expenses, including an expected operating budget of between $850,000 and $1 million.
The Landis Theater reopened in May 2010 after having shuttered its doors for more than two decades.
The Landis foundation spent close to $10 million to renovate the performance center.
However, the theater, originally built during the Great Depression, has been hit hard during this latest recession.
According to reports last year, Vineland City Council gave the theater a $500,000 line of credit, of which only $100,000 remains.
Despite the Landis Theater's recent economic troubles, Packer said Appel has the experience and staff to turn the landmark around.
"As it stands, there are only two people in charge of running the theater," said Packer. "At Appel, we have 21 employees, a significant portion of which will be focused on the Landis Theater — doing marketing, fund-raising and operations.
"Our staff is also highly experienced — together they make up more than 100 years in the performing arts."
Packer also stated Appel will begin efforts to promote the 650-seat theater not only within the county, but throughout the entire Delaware Valley region.
"You've got to get people in the theater, so we're going to have a broad array of programs, with different genres of music and theater," added Packer. "So you reach different audiences.
"The Landis Theater Foundation is full of great people who care very much about the theater — I feel it's going to be a happy marriage working with them."
Appel currently has an annual budget of approximately $3.5 million, according to Packer.
The nonprofit's most recent work within Cumberland County includes murals in Vineland, on Landis Avenue, and Bridgeton, near the intersection of Commerce and Laurel streets.
Contact Jason Laday at (856) 451-1000, ext. 416 or firstname.lastname@example.com.


text:
New Crane Safety Regulations Effective Today
BALTIMORE (April 6, 2009) Department of Labor, Licensing and Regulation Secretary Thomas E. Perez and Labor and Industry Commissioner Ronald DeJuliis announced that new regulations designed to better protect workers and ensure the safety of crane operations take effect today.
The new regulations are among the strictest in the nation, and are the result of recommendations made by a crane safety task force convened by Commissioner DeJuliis last year. The task force was comprised of a cross section of industry, labor and regulatory representatives and was charged with developing a strategy to increase training levels for crane operators, operator trainees, riggers and signal people.
Maryland workers deserve to have the confidence of knowing that their worksites are safe, and that the state is doing everything in its power to ensure their well being, Governor Martin OMalley said. I applaud Commissioner DeJuliis for convening the stakeholders and helping to gain approval for safety regulations that can serve as a model for other states.
Recent accidents across the country have demonstrated the risks involved with crane operation, and show the need for stringent requirements to protect the safety of all workers, Commissioner DeJuliis said. Marylands new regulations will ensure only those with the proper training and qualifications will be involved in crane operations.
The new regulations do not require certification, but do require specified training levels for those involved in crane operations, and require employers to keep training records. They also require daily inspections of crane equipment.
We have an obligation to ensure the safety and health of all workers across Maryland and to continue to strive for better protections for working men and women. These new regulations will help us fulfill that obligation, Secretary Perez said.
While the new regulations are effective beginning today, contractors and employers to whom the regulations apply will have a transition period through the end of the calendar year, during which Maryland Occupational Safety and Health will inspect for compliance, but will not issue citations or sanction civil penalties for any violations of the new requirements. Notices of violations will be issued to help assist contractors with compliance. For more information about the new requirements, visit our website.


text:
24 Polymer Clay Tutorials: Polymer Clay Jewelry, Home Decor, and More
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Petite Kids Cushion
By: Samelia's Mum
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Kids love it when adults find creative ways to show they care. This Petite Kids Cushion by Samelia's Mum is the perfect way to do just that. It is a simple DIY cushion tutorial for busy moms like you. You can use stuffing or seeds for the inside, but if you are using it as an idea for the tooth fairy, keep in mind that stuffing might be easier in the long run. Your children will wake up to this cool homemade craft and happily celebrate one of life's milestones: losing their first tooth.
- 2 x 5" squares of fabric
- 2" x 4" piece of fabric (pocket)
- Ribbon (optional)
Polyester filling or something to stuff the little cushion
Fold 1/8" along the long side of the pocket and press.
Fold in half and place on the corner of the print square. Top stitch it down to the print fabric.
Pin ribbon in place.
Place the backing fabric on top – right sides together and stitch along the top using a 1/4" seam.
Sew along the bottom next, making sure you move the ribbon out of the way.
Stitch along one side and finally sew the remaining side, ensuring you leave a small gap to turn out the cushion.
Clip the corners and turn it out. Use a pencil or knitting needle to poke out the corners so you have lovely points.
- Stuff with the polyester filling.
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text:
Dennis Claridge Q&A
Quarterback-Punter (1961-62-63)
Robbinsdale, Minn.
HV: Is there any funny incident that comes to mind when you think back to your playing days?
Oh jeepers. The one that comes to mind was after beating Miami in the Gotham Bowl, and some sportswriter said: "Coach Devaney, why don't you kiss Claridge?" And Devaney said: "Back in Nebraska, we kiss girls." There were others, but that was probably as good as any. I wish I could relate just half of Bob's talks because he always had people in stitches. I'd pay money to have some of those moments recorded.
HV: Who were your closest friends among Husker teammates?
I roomed with Kent McCloughan and Dennis Stuewe most of the time on road trips. Lloyd Voss and John Kirby were very, very good friends. (The late) Bill Thornton was a guy I always admired. He was one of the two best football players I was ever around, pro or college. The other was Ray Nitschke with the Packers.
HV: What did you think when Bill Jennings was fired and Bob Devaney was hired?
At that time of your life, you like continuity and don't like abrupt change. It disrupts the way things are. I was scared. I was nervous. I didn't know if this guy (Devaney) would do something different that I didn't do. You don't know what someone's like until you work with them. It turned out great because when Bob came, he said, "I don't know any of you. You're all starting on page one, and those of you who are on the fourth team will be given an opportunity to be on the first team, and those of you on first are going to move down and work your way up." With Bob, everyone gets an even shot. When he and Jim Ross came in, they pretty much told us in a meeting what was going to happen. Bob couldn't have done it without Jim. The personalities of all those guys really mixed well. They were all so different. Mike Corgan. Carl Selmer. They were good people, good coaches, solid individuals.
HV: What was the fan support like in the early 1960s?
The stadium held about 35 or 36,000. The first year for a major game we probably sold seats between the 40-yard lines. I think the fan support was there. They were just waiting for something to get excited about. We sold out the Missouri game for Homecoming in '62 and the sellout streak started. We didn't win that game, but they were seeing enough positive things to keep it going and here we are 50 years later, and it's still going.
HV: How many Husker games do you see now?
We go to most of them. My wife and son are major fans just like I am.
HV: Are you in favor of a playoff system for college football?
I like the bowl system, and I don't believe in a playoff. We've already diluted the bowl system. Remember when we were co-champs with Michigan one year (1997)? What's the matter with two teams with 100 players on each team getting national championship rings? They were all No. 1, and they will all be remembered by their fans forever.
HV: What's your opinion of Nebraska's decision to move to the Big Ten?
I think it was the best of all worlds, and I think Nebraska will thrive. I think it will take us another two or three years in most of the sports to acclimate and figure out our place and I think we'll do well. The Big Ten is a great place for us academically and everyplace else. It couldn't be better. There is no down side that I can see … period. I think Tom (Osborne) knew, and I think Harvey (Perlman) knew that the other culture was not working for us, and it wasn't going to. I think we will be thankful for a long time that both of them helped us make this move.
HV: What was it like playing both offense and defense?
First of all, I was a better offensive player than I was a defensive guy. But if you like to play football, there is nothing like playing and not coming off the field. If that's your love, then it is awesome. I think for a couple of years I mostly came out when it was a punt return or kick return. As a senior, they changed the rules and you could sub two people in and I think Ron Michka, the center, came out and I came out. Defensive guys came in and took our place. As a sophomore and a junior, I loved every minute of it. There are some guys that thrive on contact. Guys like Jerry Murtaugh relish it. I could do it and did it and enjoyed it, but I didn't relish it. There is a big difference between guys that want to put a helmet into somebody whether they have the ball or not. That's just part of their physical make-up.
HV: Did you pick your jersey number at Nebraska or was it assigned?
My number was assigned. Bill Jennings had three backs and he wanted the running backs in the teens. He wanted his quarterbacks in the 20s and I was No. 24. When Devaney came in, it changed. The backs were in the 20s, 30s and 40s and the quarterbacks were in the teens. I was No. 14.
To read the entire interview, check out Hail Varsity Magazine – 50 Years of Sellouts
Subscribe to Hail Varsity Magazine today!


text:
walk it and throw in some sprints every once in a while!
I have the keratosis too. I think it's partly hormonal so you have to get that in order with stress management and sleep too. I want to start body brushing too as a helpful habit. Also congrats on bypassing dessert.
Starting weight: 225
Current weight: 195
Goal: One pull-up by December 31, 2012
Method: Schwarzbein Principle II, program for insulin sensitive/burned-out adrenals
My Primal Journey
Created by MyFitnessPal.com - Nutrition Facts For Foods
walk it and throw in some sprints every once in a while!
Someone offered to buy my entry, so if I can transfer it to her, I probably will. I haven't decided yet. I have a friend who is injured (this would be her first half but she got hurt running a 10 miler last weekend) who is also interested in selling her bib... as luck would have it, I have two people interested in buying bibs as the registration is now closed. So, I might just sell it and call it good.
Now, for the confession:
Holy sugar binge!!! OMGee... I was a monster last night! I'm not sure what came over me, but I ended up binging on sweet stuff last night. After dinner of 8 oz baked cod, 3 or 4 slices of fried zuccini, and half a bag of frozen pea pods, I decided (somewhere in my brain, I decided this) that 3 mini marshmallows was a good idea... not so much. Because then I ate 8 Girl Scouts Thin Mints before handing the last 5 of them to DH so I wouldn't also eat them. Then, I had a bowl with some sweetened coconut, dark chocolate chips and heavy whipping cream poured over top. I knew it was coming too b/c I had the urges to grab a cookie at my MIL's house.
I'm not sure what happened. I wasn't feeling emotional or stressed. I felt quite relaxed actually until the binge started. I guess maybe hormones??? I don't know.
I don't know what to do... I think maybe the leptin reset is triggering things in my brain - especially after Kalli told me berries were off limits. I think that might be part of the problem. I'm so used to having a berry snack in the evening and not being able to per the leptin protocol I think might be driving my stress center bonkers. Then again, maybe it's the carb counting and the thought that once I reach 50 carbs, no more carbs are allowed, not even primal ones... Maybe I should stop counting carbs for a bit... or at least, stop restricting them.
I want to do the leptin reset. i really do. I'm annoyed by hitting snooze in the morning. I'm annoyed by feeling tired midmorning and midafternoon. I want to feel energetic and charged. I am starting to feel a bit better each morning and seem to function more quickly, but the mid-morning thing is bothersome - especially when I'm at work. And I'm sure things will only get worse once winter gets here and it's dark in the mornings again.
I also didn't sleep worth a damn last night. My daughter woke up at 11:30 and wanted me to find her bink for her, then I came back to bed to discover DS had joined us in bed. I was tired so I didn't care one hoot, but he was spread out like a sheet, so I had to keep moving him over. Then I had two coughing spells that required me to find DD's inhaler before I ended up puking (which I suppose would have been ok given the binge) and something to drink. And then my bed felt off. It's a memory foam bed and it was like it was taking too long to bounce back from one position to the next so I'd have dips and stuff where I'm not used to having dips. Might be time for a new mattress... Sadly, we've only had this one for 4 years at the most. (Good thing for the 20 year warranty - maybe it's not meant for two fat asses to sleep on b/c it's got dips where DH and I sleep and DH says he feels like his side is broken down to the point that he feels like he's sleeping on plywood).
Today I'm donating blood - if my iron levels are in check. Twice now in the last 6 months my iron levels have been too low to donate. And I can't blame TOM for it b/c I don't get my period anymore thanks to the birth control I use. I'm hoping I can avoid the cookies. I may just leave straight out of the chair after my donation. I don't have anything to snack on, but there is a HyVee grocery store right there by the blood bank so I can go in and get something primal for lunch instead of eating cookies and drinking the Dew.
Tonight we're racing... another obstacle. Food sucks at the race track. Which makes me feel like a big lunch after donating might be in order so I can avoid the concession stand.
Only working a half day today so I better get with the tasks I have to complete for Friday. I hope everyone's having a great day. Good luck to PC with her MIL today. Good luck to Candy in finding a school for DS1. And I hope Pam and Lex had fun yesterday - can't wait to read the stories.
I don't know if anyone has posted about this already (just started reading yr blog), but opening a capsule of L-Glutamine and taking it under your tongue can help with carb cravings. It's a weird texture, but hey, as long as we're getting used to new things...
My Leptin Reset Journey
Current BF%: 35
Goal BF%: 20-23
I'm taking L-Glutamine to heal my gut, it helps with the sugar-backlash (read: yeast infection) I get when I go crazy on ice cream, but it hasn't killed my cravings.
Who knows, maybe the leptin reset won't be your answer. Or maybe it will. But I think you have to promise yourself at least 30 days of compliance before you rule anything out. It may be that you need to start at a more moderate carb approach, but still continue with the large protein breakfast. I don't recall the carb limits for the leptin reset, but maybe something like 50-75 grams to start off with, and then the next month, lower?
Depression Lies
I think you have the right idea, nameless. I'm going to work on sugar binges this weekend and see how things go next week.
Kalli, I'll read up on the l-glutamine to make sure it doesn't interact with anything else I'm taking. Thanks for the suggestion. I hadn't heard that on yet.
Busy girl! You know that's one of those less well-known binges - the straight up self-destructive one. I find I do it when actually everything is going okay: I'm not stressed, I've behaved and everything can continue going right. But then it's like I subconsciously decide that isn't exciting enough and I fill the silence of no problems with the most easily accessible problem - overeating! My problems with that used to be a lot worse and I find the best solution is just pure distraction. If I find myself thinking ... well, the girl scout cookies are right there ... I just kind of go - oh look over there! Find new music, something to organize, a friend to call, something you've needed to read. It's funny how easily the moral dilemma of whether or not you should eat something melts away when you get distracted.
Other reasons that might lead to a heavy binge that you could have to think more carefully about is:
a) Were you low on energy?
b) Maybe you aren't eating enough (or enough of a certain something)
Either way, don't feel bad for a binge - it's not productive! Just try to figure out what triggered it and try to solve that problem.
Ooo - extra problem that I sometimes have: Just the rebellion instinct - mmm, delicious rebellion. It might be better not to count for a while. You probably have a pretty good idea of what good ranges of calories, fat, protein and carbs are by looking at the portions. But when you add numbers to the picture they can feel like prison bars you want to fight your way past just because they're there.
Starting weight: 225
Current weight: 195
Goal: One pull-up by December 31, 2012
Method: Schwarzbein Principle II, program for insulin sensitive/burned-out adrenals
My Primal Journey
Created by MyFitnessPal.com - Nutrition Facts For Foods
For your feet, keep a pumice stone in the shower and give them a quick scrub every time you're in there. And put hand lotion on them when you get out. Keep some lotion on your night table, and put some on when you go to bed too. It won't be long before you see a huge difference.
I used to think taking care of your feet was such a disgustingly precious thing to do, until the summer my callouses started cracking and bleeding on me. Then it went from being, in my mind, a self-absorbed girly-girl thing to a health issue.
The disadvantage is if my leg itches now, I have to bend over and scratch it with my fingernails... LOL! I used to use the bottom of my feet.
If you end up doing the half-marathon, you could probably work your sprints in there too.
5'2", 55 years, Primal since April. Pre-Primal weight loss, from 216.6 to 157.8
Primal low: 140.2 (Dec. 3) Goal weight: 135?
Main Primal goal: beating back my CFS enough to function more normally and start writing again
More and more, our life has been governed by specialists, who know too little of what lies outside their province to be able to know enough about what takes place within it.
- Lewis Mumford
Those funny little foot scrapers with the circular divots in them work really well, too. I got mine at the dollar store. They can be used on wet or dry skin.
Judg you make me laugh!
Lex, I think you nailed it with the rebellion thing. Today has also been a bad decision day, but I'm vowing no more wheat. I had some wheat at lunch. Not too surprisingly, a couple hours later I was feeling crampy.
Sabine, I went to Walgreens and got a 4 in 1 deal that has a brush like I'd use on my daughter's hair, a stone, some sandpaper like schtuff, and what looks like what you described. I look forward to trying it out!


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East Bergholt
|East Bergholt
Church of St Mary the Virgin
East Bergholt shown within Suffolk
|2,765 (Including Flatford 2011 Census)[1]
|OS grid reference
|Shire county
|Sovereign state
|United Kingdom
|Post town
|Postcode district
|Dialling code
|East of England
|EU Parliament
|East of England
|UK Parliament
|South Suffolk
Coordinates: 51°58′33″N 1°01′00″E / 51.9759°N 1.01676°E
East Bergholt is a village in the Babergh District of Suffolk, England, just north of the Essex border.
East Bergholt and Hadleigh are the largest villages in the Stour Valley, a region historically known for its manufacture of linens[citation needed] The nearest town and railway station is Manningtree, Essex. East Bergholt is ten miles north of Colchester and 8 miles south of Ipswich. Schools include East Bergholt High School, a comprehensive for children aged 11-16, and a primary school.
During the 16th century, its inhabitants became well known for Protestant radicalism[citation needed] A few of its citizens were martyred during the reign of Queen Mary I, and the Protestant martyrologist John Foxe recorded their stories in his famous work Acts and Monuments (also known as Foxe's Book of Martyrs).
East Bergholt is the birthplace of painter John Constable whose father owned Flatford Mill. Flatford and Dedham, Essex, both made famous by John Constable, are within walking distance of East Bergholt.
Village Centre[edit]
The central area of the village includes a variety of businesses:
- Co-Operative Village Shop.
- Grier & Partners - a local estate agents.
- Fountain House Tea Rooms - a small tea room.
- The Red Lion - one of many pubs in East Bergholt.
- De'aths Bakery
- Dunthorne Cottage - a small independently run hardware store.
St. Mary's Church and bell cage[edit]
The Church of St Mary the Virgin was built in the 15th and 16th centuries, but is well known for the absence of a tower or spire to house the bells. Work began on a tower in 1525, but Cardinal Wolsey's fall from grace in 1530 brought construction to a halt and the following year a wooden bell cage was erected in the churchyard. This temporary structure still exists although not in its original position. It was moved from the south to the north side of the church in the 17th century because the occupant of Old Hall objected to the noise of the bells.
The bells are exceptional in that they are not rung from below by ropes attached to wheels, as is usual in change ringing, but the headstock is manipulated by hand by ringers standing beside the bells.[2]
The bells are believed to be the heaviest five (A, G, F#, E, and D) that are rung in England today, with a total weight of 4¼ tons.
Other important buildings[edit]
- Old Hall, with over 100 rooms and 355 windows has been in its time a manor house, nunnery, army barracks and friary. It now houses the Old Hall Community, a single household of about 60 people who live co-operatively and farm organically.[3]
- Stour House was once the home of Randolph Churchill.
- East Bergholt Place, home of the Eley family and "The Place for Plants" garden centre is noted for camellias.
- Lambe School
- Bridge Cottage is a 16th-century cottage used as a location by John Constable.
East Bergholt is in the Wards and electoral divisions of the United Kingdom called Dodnash. This ward stretches north-east to Bentley with a total population taken at the 2011 Census of 3,541.[4]
The village is "twinned" with the village of Barbizon in France.
East Bergholt has a weather station for which data is available. The village experiences a maritime climate with a narrow range of temperature and rainfall spread evenly throughout the year. See Ipswich Climate data.
Housing Development[edit]
In 2014 plans were drawn up for a new 144 housing estate in the north of the village. Local residents responded by erecting multiple signs around the village campaigning for a "No" decision by Babergh District Council. A decision about the planned development has yet to be published.
In March 2016, Babergh District Council approved the plans for a new housing development, despite strong opposition from Action East Bergholt Group and many concerned residents.
- ^ "Parish population 2011". Retrieved 12 September 2015.
- ^ "Bells | The Benefice of East Bergholt and Brantham". Eastbergholtchurch.co.uk. 2013-11-21. Retrieved 2014-03-15.
- ^ "Old Hall Community". Oldhall.org.uk. Retrieved 2014-03-15.
- ^ "Dodnash ward population 2011". Retrieved 12 September 2015.
External links[edit]
|Wikimedia Commons has media related to East Bergholt.
- "East Anglian Film Archive: "East Bergholt" search results - eafa.org.uk". Retrieved 2 May 2012.


text:
August 11, 2013, 12:24 PM
Has anyone ever tried AA1680 powder in either 357 Maximum or 500 S&W Magnum? I have heard it's the most accurate in 357 Max and I'm thinking maybe it might be a great performer in the 500 also. Going to get a pound and see for myself.


text:
- Home
- Accommodation
- See & Do
- What's On
- Dining Out
- Canterbury District
- eShop
- Plan My Visit
Whitstable Castle and Gardens
01227 281726
Tower Hill,
|Sun 9 Oct
|Autumn Food Festival with Classic Cars
|Sun 16 Oct
|Wedding Open Day
|Mon 24 - Sun 30 Oct
|Scarecrow Festival and Trail
|Fri 28 Oct
|Murder Mystery Evening
|Sun 4 Dec
|Christmas at the Castle
|Sun 11 Dec
|Christmas Food Festival
Whitstable Castle and Gardens offers guests a Cream or Afternoon Tea with Castle and Garden Tour from just £12.95 per person. Booking is essential, by phone or email.
Our Garden Tours are led by the Castle's Head Gardener.
Whitstable Castle and Gardens welcomes groups visits. Guided tours of the building are available, and may be pre-booked with the Castle office before arrival. We are able to arrange for refreshments on arrival, afternoon teas and light lunches if desired.
From £5.00 per person dependent on catering requirements.
9 miles from Canterbury via A290. The train station is 0.9 miles to the castle and bus stop on Tower Parade (under a minute walk to the castle).
: 1 miles from Whitstable station


text:
Dukes Shut Out At Dayton, 3-0
Oct. 15, 2004
Dayton, Ohio - Duquesne University's volleyball team was shut out by the Dayton Flyers, 3-0 (32-30, 30-26, 30-25) Friday night at the Frericks Center.
Sophomore Amanda Haeg (New Prague, Minn. / New Prague) paced the Dukes with 12 kills and four blocks. Junior Diana Wuebker (St. Henry, Ohio / St. Henry) had 12 digs and four blocks. Senior Erin Trageser (Pittsburgh, Pa. / Baldwin) contributed 11 digs. Freshman Kristin Garnett (Frankfort, Ill. / Lincoln-Way East) again averaged double-digit assists with 33 in the three matches.
Christy Utnage led UD (13-7, 5-1 A-10) with 24 kills and Adrieene Green saved 17 digs. Nichole Schott had 42 assists.
The Dukes (9-12, 2-4 A-10) head to Cincinnati for another Atlantic 10 road contest at Xavier (11-8, 5-1 A-10) on Sat. Oct. 16 at 4:00 p.m.


text:
For the Fall 2002 issue of CRITICAL SENSE, the University of California, Berkeley's graduate journal of political and cultural theory, we invite submissions from graduate students nationally and internationally on the turns, returns, or turn-offs of theology, religion, spirituality, or spirit (historical or contemporary) in cultural and political theory and practice. We are especially interested in papers that consider the nexus of religion or spirituality and gender, sexuality, or sexual culture; the role of "religious" discourse in local, regional, or global geopolitics, pre- or post-September 11; and recuperations of religious thought in the theory, philosophy, literature, art, and political praxis of the Americas, Africa, Europe, Asia, the Arab world, the Pacific world, and their diasporas.
We also welcome book reviews on any topic, whether related or unrelated to the issue's theme.
Papers should be no more than thirty pages; reviews, no more than ten.
All submissions must be delivered on or postmarked by FRIDAY, JUNE 28,
2002, to the following address:
Questions? Contact the editors at the email address below.
CRITICAL SENSE brings a high level of theoretical sophistication to
interdisciplinary and cross-cultural dialogue. It publishes innovative
and serious scholarship by graduate students and helps nurture a new
generation of scholars doing cutting-edge work in the humanities and
social sciences.
--Lydia H. Liu, Professor of Comparative Literature and Helmut F. Stern
Professor of Chinese Studies, University of Michigan


text:
Turnout across county pegged at 28 percent, less than expected
November 6, 2013
LISBON — Only 28 percent of Columbiana County's registered voters bothered to cast a ballot in Tuesday's election, including 1,273 people who chose to vote early....
I think more and more people are getting fed up with crooked politicians, a broken system and an increasing number of people who just stand with their hand out waiting on the next check. Once you believe there's no use trying to fix it and that it's just going down the drain, you quit voting, hunker down and just wait for the zombie apocalypse.
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