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Quadruple Helices Appear To Have Role...
As Immunotherapy Revolutionizes the Cancer Treatment...
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
Biotechnology stocks were up about 12% over the past 12 months through February 2011, underperforming the Nasdaq, which was up 29%. The NYSE Arca Biotech ETF did better, up 23%. Since the recent market bottom in August, the Nasdaq composite outperformed biotech by more than 12%.
Biotech stocks can catch up in 2011 as many new products are expected to launch. Moreover, the clinical pipeline is robust with more than 2,000 products in Phase II or later and almost 5,000 in Phase I and later. In addition, M&A activity should continue as larger cap companies with strong balance sheets acquire technology and pipeline. One major issue is whether new technologies can address therapeutic needs in a cost-effective manner and obtain HHS and CMS reimbursement.
Over the past 20 years, breakthrough technologies in the life sciences have resulted in over $50 billion in new product sales. Monoclonal antibody technology still accounts for most of the multibillion dollar biological products such as Avastin for cancer and Remicade and Humira for rheumatoid arthritis. Data provided by Kalorama Information for 2009 shows that revenue for the top biotechnology products was $51.3 billion (Table).
Of these top biotechnology products, most are indicated for cancer and autoimmune diseases. Over 60 late-stage biotech products have revenue potential of $13 billion in 2015. Recombinant engineered (rDNA) cell lines offer a vast portfolio of products for new vaccines, gene therapy, and monoclonal antibodies with 25 major products expected in the 2011 launch cycle such as Human Genome Sciences' belimumab for lupus and Amgen's denosumab for oncology.
Scientific themes and clinical milestones drive investors' interest in addition to top-line revenue growth. Many emerging technologies are coming on the market in 2011 and will have a major market impact in the intermediate term.
Two very promising technologies that have excited both Wall Street and scientists are antisense and RNA interference (RNAi). After more than ten years and billions of dollars in development, these technologies have had a number of clinical and business setbacks but are still being aggressively funded at about $250 million per year. Two companies that are highly focused in these areas are Isis Pharmaceuticals for antisense and Alnylam for RNAi.
A major breakthrough in the treatment of prostate cancer was FDA approval of Dendreon's Provenge after more than 10 years of R&D and $1 billion in funding. The product is on the market with forecasts in the $375 million range for 2011, with potential peak revenues at $4 billion.
Provenge is an active cellular immunotherapy utilizing the patient's own cells to elicit an immune response to destroy cancer cells. Additional products are in the Phase I pipeline to treat breast, ovarian, and colon cancers targeting the Her2/neu receptor.
The company recently completed $500 million in funding through a convertible debt offering and is expanding its manufacturing in the U.S and Europe. The cost for Provenge treatment in the U.S. is $93,000/year but reimbursement in Europe may be lower. EU approval is expected in early 2012.
One big cost advantage of Provenge over other cancer treatments such as chemotherapy is that it requires less supportive care to treat side effects. As the drug gains acceptance the focus will shift to cost effectiveness and life extension now pegged as much as 10 months longer than patients not treated.
A September 2010 Kalorama Information report estimates the cancer vaccine market for 2011 at $2.2 billion, it is forecasted to grow to $7.7 billion in 2015 driven by the approval of Provenge.
The major indications for cancer vaccines will be prostate and cervical cancer, with Dendreon expected to dominate the prostate market with 93% share or $5.9 billion in 2015. Cervical cancer vaccines to prevent HPV infection currently on the market—Cervarix (GlaxoSmithKline) and Gardasil (Merck)—are preventive not therapeutic, and are forecasted at $1.8 billion in 2015. This forecast may be low as a higher incidence of HPV is now being reported in males.
OncoThyreon's Stimuvax therapeutic vaccine utilizes a cancer-associated marker called MUC-1 in a liposomal formulation (BLP25) to create an immune response. Two Phase III trials are under way initially for non-small-cell lung cancer. The product is being funded and developed by Merck KGaA under a license from OncoThyreon.
Geron is in a Phase II trial with an autologous dendritic cell vaccine targeting telomerase in patients with acute myelogenous leukemia.
Vaccinogen has four fast-tracked products in clinical trials using its OncoVAX platform for indications in colon cancer, melanoma, and renal carcinoma. A Phase IIIa trial in the Netherlands demonstrated efficacy with stage 2 colon cancer patients. OncoVAX utilizes the patients own tumor cells patient to create an immune T-cell response capable of destroying cancer cells.
Oxford BioMedica has technologies in gene delivery and immunotherapy. The 5T4 tumor antigen, a unique protein found in many cancers, is utilized in the company's TroVax therapeutic vaccine currently in a Phase II trial for prostate cancer. An antibody program is also under development.
Rod Raynovich ([email protected]) is a principal at Raygent Associates.
Rod Raynovich ([email protected]) is a principal at Raygent Associates.
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|Pseudo-Single-Bunch Expands Experimental Scope
Initial tests of a new pseudo-single-bunch (PSB) operational mode at the ALS have shown promising results—PSB would vastly expand the facility's capacity to carry out dynamics and time-of-flight experiments with a major reduction in sample damage. In PSB operation, a single electron bunch is displaced transversely from the other electron bunches circulating in the storage ring. Experiments that require light emitted only from a single bunch can stop the light emitted from the other bunches using a collimator. Other beamlines would only see a small reduction in flux due to the displaced bunch. As a result, PSB complements the scheduling of multibunch and timing experiments—currently, the ALS only offers these capabilities for four weeks out of its yearly operating schedule. With PSB operation, the ability to conduct time-of-flight experiments could be available year-round.
Watch a video on this topic.
The ALS has been successful in serving multiple users with a diverse set of requirements such as high-photon flux and brightness, a large range of wavelengths, variable polarization, and relatively short pulses. However, a major limitation of the ALS and other synchrotron light sources is the inability to serve two other classes of experiments simultaneously—brightness or flux-limited experiments and timing experiments. Typically, storage ring light sources operate with the maximum number of bunches possible, with a gap for ion clearing. By evenly distributing the beam current, the overall beam lifetime is maximized. The ALS normally operates with a train of 276 bunches out of a possible 328, with a single "camshaft" bunch in the middle of a 100-nanosecond gap.
The concept of using a camshaft bunch in multibunch operations started many years ago and originated out of the desire for some timing experimenters to operate during multibunch mode. However, most timing users cannot use the camshaft due to the short 100-ns gap. The ones that do must use gated detectors or expensive mechanical choppers to reduce the background from unwanted bunches. These choppers are challenging to fabricate and operate, and for beamlines that operate without a monochromator, they have to absorb about a kWof power while rotating at high speeds. Furthermore, the rotating frequencies of choppers constrain the repetition rate of the external laser.
The idea behind PSB operation is to use a high-repetition-rate (MHz), short-pulse (<100 ns) magnet to vertically kick the camshaft bunch relative to the bunch train. Then, by blocking the light from the multibunch train in the beamline, only light from the camshaft bunch reaches the experiment. Putting this bunch in the middle of the ion-clearing gap reduces the required bandwidth of the kicker magnets.
PSB operation has been tested at the ALS in various forms. For example, using one kicker magnet running at the ring repetition rate (1.5 MHz), PSB can be operated in a fixed high-repition-rate mode by permanently putting the camshaft bunch on a different orbit. It can also operate in an adjustable repetition-rate mode from milliseconds to microsecond with a novel ''kick-and-cancel'' (KAC) scheme. By adjusting the ring tune and the PSB kick pattern, the camshaft bunch can be first displaced to a different orbit and then kicked back to its original one within a few turns. This kick-and-cancel process can be repeated on demand, thus creating single-bunch pulses with adjustable repetition rates. This KAC scheme can significantly alleviate complications of using high-power choppers and substantially reduce the rate of sample damage. It allows the use of non-gated detectors, greatly increasing the variety and quality of experiments that can be done.
Research conducted by: C. Sun (ALS), G. Portmann (ALS), M. Hertlein (ALS), J. Kirz (ALS), and D. S. Robin (ALS)
Research funding: This work is supported by the Director Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. Operation of the ALS is supported by the U.S. Department of Energy, Office of Basic Energy Sciences.
Publication about this research: C. Sun (ALS), G. Portmann, M. Hertlein, J. Kirz, and D. S. Robin (ALS), "Pseudo-Single-Bunch with Adjustable Frequency: A New Operation Mode for Synchrotron Light Sources," Physical Review Letters. 109, 264801 (2012).
ALS Science Highlight # 274

subset: commoncrawl


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08 May 2011 44 Comments
A Love Letter to Maui
Get ready for a love fest. Maui means so much to me. Not just because it's incredibly beautiful, which it is, but because it holds a lot of really precious memories for me. I lived there for the first few years of my life on a small mom-and-pop style resort managed by my grandparents, known(…)


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Those years, months, and days don't seem like a lot in the grand scheme of things considering I've been alive for almost 24 years now. But knowing that we have not only loved one another, but worked hard to grow together as a couple from a distance makes me feel incredibly grateful.
My parents dated long distance when they first started out, and it wasn't until 3 years later when they were married that they lived together in the same city. I admire them. They've been happily married for more than 25 years, and I know that M and I were meant to start out this way. Because we love each other and want to be together, it forced us to grow up and helped me change.
I never thought that one person could have a big enough place in my heart to make me want to be better, not just for him, but for myself. So here are some of the many things that I learned about me, continue to work on, and try to improve.
1. I dropped my passive aggressive habits. For a long time, I was (and still can be) extremely passive aggressive. But acting that way does not solve problems, and it's even harder to deal with someone acting this way from a distance. So instead of pretending like something's fine, even when it's not, I forced myself to communicate.
2. Communication is probably the biggest thing I learned about what a healthy relationship needs to thrive. If something bothered me, I would tell him. If something I liked happened, I would tell him. If something upset me or hurt my feelings, I would tell him. If I needed something different or more, I would tell him. This was not easy, and I still struggle with it, but I continue to communicate.
3. Along with communication came the promise of never lying to him. No matter how big or small, I promised I would not lie. And so, I haven't lied. I haven't said "I'm fine," if I'm not. And I haven't told him that I wanted to do something, if I didn't. Honesty is a major key.
4. I get disappointed far too easily, especially when it came to seeing (or not seeing) M. And it would always send me into lots of tears. This isn't something I'm proud of, but it's something that makes me who I am. The amount that I feel heightened And being in a long distance relationship helped me embrace those feelings instead of trying to stuff them away.
There are many other things that I've learned along the way, and I will continue to learn, but these were the front runners. Compromise, honesty, communication, trust, and love are those major things in life that can make many miles not seem so far away. Fortunately, I get to see my M every day now, but I'm grateful that we had this learning process too.


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Gypsy Rosalie
Gypsy Rosalie is an online retailer of vintage linens and textiles for
collectors and home decor. She has been featured in Collector's News
magazine, and from time to time, her items have appeared in Country Home
magazine. Most of her linens and textiles are one-of-a-kind treasures,
usually found on the East Coast.


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on October 9, 2012 - 8:52 PM
LITTLE VALLEY – An Olean was ordered to serve two to four years in prison Tuesday as a repeat felony offender.
Cattaraugus County Judge Larry M. Himelein imposed the sentence on Sandra L. Sherlock, 32, after her guilty plea to attempted burglary and petit larceny.
She was accused of illegally entering the Town of Allegany Walmart store after having previously been ordered to never enter the store again.
Sherlock served about two years in prison for a forged check conviction in 2005 while living in Salamanca.


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Welly Goes A-Ballin' at Riverview Park
Welington Castillo homered, doubled, and singled, Jesse Hodges doubled twice and walked, and Duane Underwood tossed four innings of no run/no hit ball, as the Kane County Cougars rallied for two runs in the bottom of the 9th to edge the Burlingtom Bees (Los Angeles Angels Lo-A affiliate) 7-6 on Field #3, while the Inland Empire 66ers (the LAA Hi-A affiliate) drubbed the Daytona Cubs 12-3 on Field #6, in Cactus League Minor League Camp action this afternoon at the Under Armour Performance Center at Riverview Park in Mesa, AZ.
Castillo was "visiting" from MLB Camp, getting six Plate Appearances total between the two games. He moved back & forth between the two adjacent fields, serving as an extra DH and getting a PA whenever the opportunity presented itself. The HR was a line drive-blast over the LF fence in the Hi-A game on Field #6, the double one-hopped the CF fence (also on Field #6), and the single was drilled through the 5.5 hole on Field #3. After bouncing out 3-1 and going down on strikes (swinging), Castillo flied out to the warning track in RF in his last AB of the day.
Dillon Maples got the start for the D-Cubs in Field #6, and immediately threw 10 consecutive balls to start the game. Before he was relieved with one out in the top of the 3rd inning, Maples had allowed five runs on two hits (a triple and a single), six walks, an HBP, and two WP.
Duane Underwood on the other hand was absolutely masterful on Field #3, setting down the Bees with minimum difficulty. He mixed his fastball, change-up, and curve very effectively, and never was in trouble in any of his four frames.
The defensive gems of the day were turned-in on Field #3, as CF Rashad Crawford made a spectacular diving catch in left-center after a long run, and then 2B David Bote made a two-out run-saving leaping catch to snare a screaming line-drive seemingly headed for CF (as he jumped higher than he knew how). Both Crawford (who was an outstanding HS basketball player with the nickname "Baby Jordan") and Bote are super-athlectic, and so it's not surprising that they were today's Dynamic Duo of Defense.
Here are the abridged box scores from today's Minor League games at Riverview Park (Cubs player only)
X. Welington Castillo, DH #1: 1-2 (1B, F-9)
NOTE: W. Castillo hit 2nd in the bottom of the 1st & 5th
1a. Gleyber Torres, SS: 0-1 (BB, F-9, R)
1b. Alex Sanchez, SS: 1-2 (BB, L-3, 1B. R)
2a. Kevin Brown, RF: 1-2 (6-3 DP, 1B, PO)
2b. Trevor Gretzky, RF: 1-3 (1B, P-3, 6-4 FC, R, RBI)
3. Jesse Hodges, 3B: 2-4 (2B, BB, 2B, P-4, F-7, R, RBI, PO)
4. Eloy Jimenez, DH #2: 0-4 (3-U, P-4, K, K)
5. Jacob Rogers, 1B: 1-4 (F-8, L-6, 1B, K, 2 RBI)
6. David Bote, 2B: 1-2 (BB, 1B, HBP, E-6)
7a. Alberto Mineo, C: 0-2 (1-4 FC, 1-6-3 DP, R)
7b. Rony Rodriguez, C: 0-2 (P-4, 1-4 FC, R)
8. Charcer Burks, LF: 1-3 (BB, F-8, F-9, 1B, R)
9. Rashad Crawford, CF: 2-4 (1B, 3-1, P-4, 1B, 2 RBI)
1. Duane Underwood: 4.0 IP, 0 H, 0 R, 2 BB, 2 K, 5/5 GO/FO, 53 pitches (34 strikes)
2. Erick Leal: 1.0 IP, 3 H, 5 R (5 ER), 3 BB, 1 K, 1 WP, 2/0 GO/FO, 47 pitches (23 strikes)
3. James Pugliese: 2.0 IP, 1 H, 1 R (1 ER), 1 BB, 2 K, 0/4 GO/FO, 29 pitches (20 strikes)
4. Orbandy Rodriguez: 1.0 IP, 0 H, 0 R, 1 BB, 0 K, 1 WP, 1/2 GO/FO, 17 pitches (7 strikes)
5. Tyler Bremer: 1.0 IP, 0 H, 0 R, 0 BB, 0 K, 0/3 GO/FO, 8 pitches (4 strikes)
3B Jesse Hodges - E-5 (fielding error allowed batter to reach base safely)
X. Welington Castillo, DH #1: 2-4 (2B, 3-1, HR, K, 2 R, RBI)
NOTE: W. Castillo hit 2nd in the bottom of the 1st, 2nd, 3rd, and 5th
1. Shawon Dunston Jr, CF-LF: 1-4 (K, K, 1B, 1-3, RBI)
2. Carlos Penalver, SS: 1-4 (1B, 4-3, K, 5-3, RBI, CS)
3a. Rock Shoulders, 1B: 2-3 (1B, K, 1B)
3b. Ben Carhart, PH: 0-1 (K)
4a. Yasiel Balaguert, RF: 0-2 (5-3, P-4)
4b. Reggie Golden, RF: 0-2 (2-5-3 DP, E-6)
5a. Danny Canela, DH #2: 0-1 (F-8, BB)
5b. Zak Blair, PH: 0-1 (K)
6a. Cael Brockmeyer, C: 0-2 (K, 6-4 FC)
6b. Justin Marra, C: (0-1 (F-8)
7. Jordan Hankins, 3B: 1-3 (F-8, F-8, 1B)
8. Danny Lockhart, 2B: 1-3 (5-3, F-8, 1B)
9. Trey Martin, LF-CF: 0-2 (P-3, BB, K, R)
1. Dillon Maples: 2.1 IP, 2 H, 5 R (5 ER), 6 BB, 2 K, 1 HBP, 2 WP, 3/2 GO/FO, 66 pitches (29 strikes)
2. Jose Arias: 2.0 IP, 3 H, 1 R (1 ER), 1 BB, 4 K, 1 HR, 1/1 GO/FO, 38 pitches (24 strikes)
3. Justin Amlung: 1.2 IP, 0 H, 0 R, 1 BB, 0 K, 1/3 GO/FO, 23 pitches (11 strikes)
4. Jasvir Rakkar: 1.0 IP, 6 H, 5 R (5 ER), 0 BB, 1 K, 1 WP, 1/1 GO/FO, 35 pitches (23 strikes)
NOTE: Rakkar's first inning was stopped with no outs and runner at 2nd base (after five runs had scored)
5. Hector Perez: 0.2 IP, 1 H, 1 R (1 ER), 1 BB, 1 K, 2 HBP, 0/1 GO/FO, 21 pitches (11 strikes)
NOTE: H. Perez's inning was stopped with two outs and bases loaded after second HBP of inning
SS Carlos Penalver - E-6 (fielding error allowed batter to reach base safely)
Cael Brockmeyer: 0-2 CS
Justin Marra: 1-2 CS
WEATHER: Sunny & cloudless with temperatures in the 80's
I wonder what a breakout
I wonder what a breakout season from Castillo would look like.
30 doubles and 18 HRs? Any
30 doubles and 18 HRs? Any increase in offensive value probably has to come in slugging percentage. It's hard for me to imagine him beating the .274 batting average this time around.
I can live with that
I can live with that
olt and baez with back to
olt and baez with back to back opposite field HRs.
This makes me happy.
This makes me happy.
Olt 2 run HR in top 3rd. A
Olt 2 run HR in top 3rd. A blast. Followed by another blast by the Cubs 2nd baseman tonight. Who is that masked man?
Even Brett Jackson looks a
Even Brett Jackson looks a bit better, triple after an rbi double by McDonald. 5 run 3rd inning. 5-0.
he's got a controlled
he's got a controlled/powerful swing...too bad he doesn't have the batting eye to go with it.
even when he fouls stuff off, it comes off the bat 100000mph. if he squared up on the barrel more stuff that he makes contact with, things could get ugly for opposing pitchers.
It's amazing how bad his
It's amazing how bad his results are for a guy who looks like such a good baseball player.
If he's built well and keeps
If he's built well and keeps doing things right, his numbers will come around.
Whenever I see Jackson I
Whenever I see Jackson I think of Corey Patterson. Patterson never looked like he had baseball-type skills. He was a good raw athlete, but didn't look like a baseball player to me. Jackson has a classic "pretty" swing, which may be a way of a guy like me who maybe doesn't know every nuance of baseball of saying he looks good trying, but he just up till now hasn't had it click for him. I assume it's routine for baseball teams to give eye checkups, but sometimes it just seems like he doesn't see the ball. I had bad vision as a kid and had trouble hitting a softball.
Nice AB by Jackson on his
Nice AB by Jackson on his triple.
Cabrera has a 1-2-3 inning in
Cabrera has a 1-2-3 inning in 6th including striking out Profar.
scoreless 2nd inning of work
scoreless 2nd inning of work by Cabrera, gets Choice, Fielder and Rios out. 2 hard hit balls out of the 6 outs, but has to give him an edge considering he's out of options.
and Baez with a double..
and Baez with a double...BEAST MODE
and steals 3b, altough should
and steals 3b (with 2 outs for some reason), altough should have been out. Kouzmanoff (still alive) missed the tag. Looked like a delayed steal of some sort.
followed by a steal of 3rd
followed by a steal of 3rd
former Cub Jim Adduci
former Cub Jim Adduci destroyed a Rivero fastball to tie game in 8th, 6-6.
Rivero does look to have some late-inning potential, big, tall kid...hit 97.
haven't seen b.schlitter in a
haven't seen b.schlitter in a few years...he's working on a hell of a head of hair.
sweet, extra innings means
sweet, extra innings means bonus Javier Baez AB
rips a liner straight to shortstop
on a Baez note, doesn't look like he has a body that is going to keep him at shorstop or 2b his entire career.
I was watching him last night
I was watching him last night, thinking that he reminds me of a RF in a lot of ways. I wouldn't be surprised to get him work there eventually, especially if Soler doesn't pan out.
this one ended in spectacular
this one ended in spectacular cubs-like failure with 2 outs in the bottom 10th...up at one point 6-0, lose 6-7 after 10.
at least the damage in the 10th (and 7th) came from guys who doesn't have a chance of making the MLB club.
spring don't mean a thing..
spring don't mean a thing...and all that...but...
j.lake is 4/28 with 1 walk (.143/.167)...no x-base hits...and 13Ks.
r.sweeney is 2/26 with 1 walk (.077/.111)...no x-base hits...and 6Ks.
these are supposedly the cubs 1+2 options for CF (with lake being the majority player) unless they plan on shuffling ruggs (who's having an awesome spring) up to majority CF duty and leaving lake/sweeney to scramble for playing time.
at least there's options and all 3 are expected to make the team...and r.kalish is waiting around as a capable backup...boni can play CF, but offers little else outside of speed and hitting singles as a starter...i don't wanna talk about b.jacKson.
fwiw, lake had a rather good winter ball...could be a small sample size or whatever...not like he's expected to be a superstar anyway. the Ks more than the avg/ob% slash line bothers me, though.
If (when) Lake scuffles I
If (when) Lake scuffles I expect Jackson will get another shot.
Hoping for a breakout year
Hoping for a breakout year for Underwood!
Levine says Tigers "top
Levine says Tigers "top executive" watching Barney and Schierholtz.
pretty much expected..
pretty much expected...especially since they seem to not be in on the ARZ SS surplus that the mets are heavily scouting.
and on the j.rollins front
and on the j.rollins front from his happy home in PHI...
"I don't care which way it is tried to be twisted or said, or if it is exactly how it was said, or even if it was said, I can't be traded," he said. "It doesn't matter. If I was tradable it may have weight because that means I could be moving soon. But I am not tradable and so it doesn't matter."
Dude is a motherfucking poet.
Dude is a motherfucking poet.
still searching for a few
still searching for a few more owners for a Fangraphs Ottoneu League, We have 3-6 spots open (a few folks I'm waiting on). Need to fill league by this Friday. It's a $9.99 fangraphs points league, but we'll be doing another $40 or so buy-in using leaguesafe.com. Current draft day is Sat, April 5th at 10am CST, but that is subject to change if that's your hold-up.
Pains in the asses need not apply...
drop your email here or use contact form in upper right (send to Rob G. of course)
I can vouch that this is THE
I can vouch that this is THE league of the season. It's a virtual who's
who that? of internet baseball. If you've ever wanted to rub digital elbows with the type (get it?) of people who moniker themselves with a direct article (and thrive in the realm of wordification and transpartofspeachification), this is the place.
Hoo boy! This comment is a
Hoo boy! This comment is a little wordplay gem all in itself!
chc/col live tonight on MLB
chc/col live tonight on MLB Network, 9:40pm (ET)
fwiw, it will most likely be the ROOT Network (COL) providing the feed.
No Olt today, was suppose to
No Olt today, was suppose to play 3b...shoulder still bugging him a little.
-edit- apparently gonna start tomorrow at 3b instead
I could literally just watch
I could literally just watch replays of Javier Baez homers all day long.
I kinda want to see him play
I kinda want to see him play Iowa down here in Round Rock - but I more wanna see him push Theo into a too early call up.
I see this service-time issue
I see this service-time issue becoming HUGE in future negotiations with the players' union. And frankly I agree that holding back players so you have longer club control is bad for the game. Not sure what can be done about it? But it really does suck for the fans and the players . . . especially great players who might be missing an opportunity to log lifetime stats towards HOF careers etc. It'll be interesting to watch in coming years . . . you can already sense the frustration bubbling.
players union doesn't care
players union doesn't care about kids. the number of them losing 50+ games to suspensions over smoking some weed is absolutely asinine. they're not even held to that standard in the bigs.
but yeah, it does suck to see the service time issue held over players...TB has been "abusing" it for years...though "abusing" might be a bit harsh for a team that's operating on their kind of revenue.
either way, situations where kids could/should be up don't materialize too often because of the service clock issue.
"We have always believed that
"We have always believed that the game suffers when teams make roster decisions based on factors other than player performance," union chief Tony Clark told FOX Sports. "The 25 players who give each team the best chance to win should be on the Opening Day roster."
Kind of a FOX Sports puff piece on the subject:
I really like the system they
I really like the system they have in place where guys have to meet certain goals before being promoted. It takes the mystery out of what's going to happen for these younger players. Instead of thinking about whether or not they will get the call up, they can focus on improving their game. Their future is in their hands and based on their performance.
That said, I agree Baez should be in AA/AAA this year. There's no rush. He's not going to put the Chicago Cubs over the top. And I don't think it's going to hurt the game or hurt Baez's career, they just want to protect his value as a prospect and keep him under club control as long as they can.
Recent comments
j.buchanan with a nice start...5ip 2h 1bb 3k, 0r/er
zobrist with 2HR and a double through 8
heyward 0-4 :(
Mark Gonzales @MDGonzales
Soler likely to return Sunday, Maddon says
Right now, I'd like to see the Mets first, Giants 2nd.
I believe that since most of the team from last years' NLCS is on the squad this year, they will really amp their game up even more to kick their ass in payback for 2015.
The Giants just do not have the depth in years past, and I think all things equal - and at Wrigley - they could handle them.
I do not want to see the Cards, period. Or their fans, media, or Joe Buck.
I don't want to play Braves in the first round. Any friggin team in the league can win 3 of 5..I hate the first round. Furthermore, I wanted to play the Marlins in 2003 and the Mets over Dodgers last year.
With that said in reverse order:
3. Cardinals: It will be devastating to lose in the first round, but even worse to their main rival. It is increased incentive for the Cardinals, especially after last year. Cards would have nothing to lose, Cubs have everything to lose.
2. Giants: Rotation in the playoffs scare me a bit, but what a lousy team.
1. Mets--because of the losses in the rotation
2. Giants--because they're not the team they were BUT they maybe have bullshit even-year magic?
3. Cardinals--because rivalry and not making the playoffs hurts them more than losing in the NLDS plus getting eliminated by them in the playoffs would make for horrible sports commentary next throughout next season.
Who's asking?
CLE/DET rained out last night already, possible rain-outs in New York (vs. Baltimore), Boston(vs. Toronto) and Philly(vs. Mets) this weekend too.
Not only games involving playoff spots that would need to be played, but any that involve home field advantage.
I got the first one! Second one I'm not even sure what even/odd betting is.
any opponent preference for NLDS?
Mets are down to 1 great pitcher instead of 4. Syndegaard may pitch Sunday which means if Mets win the WC game, he'd be set up for Game 1. There's a chance they clinch a spot by Sunday so he'd pitch the WC and then we'd probably get Colon for Game 1. They've certainly had the hottest bats over the last week and month out of the WC options.
A couple of Cub related puzzles.
Can't teach height and thinness
Hopefully Pirates don't call up A. Lincoln.
j.buchanan going friday...should be...baseball...or something like it.
Wow. I didn't know they could do that.
Nice for Willson, not so much for Addy.
Game is officially called...also officially a tie.
Stats count, no make-up date of course.
Yeah -- seeing the weather -- I hope KB and Rizz are inside, wrapped in blankets and drinking hot chocolate.


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Mammal of the Month
Mammals Curator Bob Timm will share information about one mammal species each month at a special drop-in event for children and families. Watch for information on the museum's Facebook page to learn what the featured mammal of the month will be.
November 02, 2013
11:00 am - 12:00 pm
Dyche Hall, 6th floor gallery


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Prison Slang for forcing a perfectly heterosexual male into an involuntary homosexual relationship and identity role through coersion, violence, or threat of violence.
"Big Tony will 'Flip A Bitch' later tonight during showers. I think his name is Al."
von Jem'Hadar 21. Juni 2009
to get Angry, Loose, or Exited.
If i tell him hes ganna flip an bitch.
Im so heated, im about to flip a bitch.
Im so heated, im about to flip a bitch.
von JoeBeFresh 16. Februar 2008
To kill a prostitute.
* Note: This term became very popular after the release of the Grand Theft Auto video games.
* Note: This term became very popular after the release of the Grand Theft Auto video games.
Did you just flip a bitch? You better clean that hooker's blood off your hands.
von Rob and Big Black 11. April 2008
to have a fit, freak out, flip out, or otherwise become quickly and unreasonably angry.
If she cuts in front of me in line again, I'm gonna flip a bitch.
von apaigeb 10. Dezember 2005
When a man is making love with a woman, front-to-front, and suddenly (and often unexpectantly) flips her around for doggy-style copulation. The woman will respond negatively or positively depending on her kinky factor (KF); but it is always good to know a woman more intimately before trying this stunt. If the man is really jumpy, he will only be facing her, anterior-to-anterior with his erection between them before attempting this quick maneuver.
"Dave's such a wimp; he won't flip a bitch the first time they 'make love'."
von beep beep bitch! 28. Januar 2007
When a cop pulls a U-turn to pull you over.
von Twon 9. Februar 2005


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The California State University (CSU) Chancellor's Doctoral Incentive Program (CDIP) aims to increase the number of promising doctoral students applying for future CSU instructional faculty positions by offering financial assistance in the form of a loan and mentorship by CSU faculty.
Established in 1987, the CSU CDIP is the largest program of its kind in the United States. As of June 2015 the program has loaned $47 million to 2,050 doctoral students enrolled in universities throughout the nation. 1,245 participants have successfully earned doctoral degrees, and over half (705 participants) have subsequently obtained employment in CSU instructional faculty positions.


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Lawmakers disappointed at VAWA's limbo status
January 13, 2013
WASHINGTON, D.C. — Federal lawmakers expressed their disappointment that the 112th Congress was unable to pass the Violence Against Women Reauthorization Act of 2012....
Thank GOD she votes against it. Someone's gotta stop the "open checkbook" spending. Just... STOP!!! Since I'm on a soapbox, hey libs, stop running to the federal gov't to make a new law every time you get a burr up your butt! Solve it on your own first.
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Why should it be refunded? Someone ought to make the case rather than just assume that a well intentioned and sympatheticall named program actually works to reduce violence. Often, these programs are run by manhaters who are the primary beneficiaries of funding. PROVE that such programs work!
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Despite what she says, if and when the time comes for a vote,Capito would find some reason to vote against it.
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Wednesday, July 17, 2013
July is a wicked month when it comes to sports.
Sure it's mid-July and we're in the midst of the baseball All-Star break, the Mid-Summer Classic as it were, but beyond that nothing much is going on.
I watched the Atlanta Braves lose to the Cincinnati Reds on All-Star Break Sunday. The Braves lost their entire starting outfield to injury within a 24-hour span. An abductor strain, a slight hamstring pull and an oblique injury.
I know there's more to the human body than connecting the ankle bone to the shin bone, but what are an oblique injury and an abductor strain? I never knew I had these.
Imagine my surprise when I did a little bit of reading and found out not only do I have four of these oblique muscles, but there has been a puzzling rise of oblique injuries lately in baseball.
The obliques are broad flat muscles that attach the rib cage and the pelvis on each side of the body. I'm looking there now, where my rib cage is connected to my pelvis and all I see is a lot of belly. I've played baseball since I was six years old and I have never hurt my oblique muscle. I guess you hurt your oblique when you swing and miss – which explains why I never hurt mine. I didn't miss … much.
It's a slow sports week so cut me some slack here. I know I wasn't the best hitter in the world. I didn't earn my money hitting, but I never hurt my oblique swinging and missing a pitch, much less getting a cramp there.
Those types of things usually kept me out of the swimming pool after lunch for 30 minutes or so.
So I did a little more reading to find out what an abductor is, and I didn't know I had one of those either.
The abductor muscles are located in the upper rear hip, which leaves me to wonder why B.J. Upton grabbed his shoulder after diving for the line drive. Or maybe he hurt his oblique and Justin hurt his abductor.
I just know one of the first lessons I learned after signing my contract with the Cubs was conduct of play on the field included what you grabbed or didn't grab in the event of an injury. I've been hit just about everywhere imaginable over the years and was fortunate enough that when I got hit in spots I wasn't supposed to grab I wasn't in front of a stadium full of baseball fans.
They told us to grab our feet in the event we were ever hit in that spot.
I figure if I'm hurting somewhere on my person and that area is located halfway between my brain and my feet, I'm not going to bypass that hurt area to continue on to the ankle and below.
That's when I learned how to duck.
Football practice starts in three weeks. I can't wait.
I'm sure given the sports doldrums we're mired in this week, you can't wait, either.
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Help Improve the Michigan Supreme Court - Attend the Mille Jeffrey Annual Dinner July 29, 2012Submitted by Steering.Jim on Mon, 07/09/2012 - 02:28
You can help improve the balance, integrity and fairness on the Michigan Supreme Court by attending the annual Justice Caucus Millie Jeffrey Dinner. The night will feature Tom Mann from the Brookings Institute. Mr Mann just published a great new book called, "It's Even Worse than it Looks....:
Read more : http://www.justice4michigan.org/2012_millie_jeffrey_dinner_keynote_honorees_announced
Buy tickets to the dinner at http://justice4michigan.org
A limited supply of 40 books will be available at the event if you wish to get an autograph from the speaker. Be sure to buy tickets to the VIP reception in order to have the best chance at meeting the author upclose and personal.
The evening promises to be a lot of grassroots fun with several local organizers from Michigan being honored with Spirit of Millie awards.
Get your tickets right away so you don't miss you place at the table!
Steering Jim
Each of Us has a Responsibility to Protect our Michigan Interests by Working hard to Improve our Insurance Company CourtSubmitted by Steering.Jim on Mon, 07/09/2012 - 02:18
Tell Markman and Zahra they are wrong for Michigan!
Help Restore Fairness and Integrity to our Michigan Supreme Court this November 6, 2012!
The time to take action is now. Sign up for the Supreme Challenge at :
Steering Jim
Keith Oberman - Terrific Monologue on LoveSubmitted by Steering.Jim on Sat, 06/16/2012 - 13:53
A must watch monologue for anyone who doesn't understand the importance and the power of love
Steering Jim
Sign the Petition Asking Bank of America to Stop the Debit Card Useage TaxSubmitted by Steering.Jim on Mon, 10/03/2011 - 02:15
Dear Reader,
Bank of America just can't help itself. The nation's largest bank just announced that it will force customers to start paying a new fee of $5 every month -- just to use a debit card.
This is the same bank that nearly tanked our economy with their reckless behavior, took $45 billion in taxpayer money, has kicked tens of thousands of families out of their homes, and has been repeatedly criticized for gouging consumers.
It's just one fee too many for Bank of America customer and Change.org member Molly Katchpole. "I can barely afford to make ends meet," said Molly, who works two part-time jobs in Washington, DC. "Now I'm expected to hand over money to Bank of America each month just for using my own debit card?"
Molly started a petition on Change.org demanding that Bank of America CEO Brian Moynihan cancel the bank's new $5 monthly debit card fee. Sign her petition now to stop Bank of America's new fees.
Even if you're not a Bank of America customer, this should matter to you. This campaign will show other banks who are planning to follow suit that the public won't stand for Wall Street's newest way to take money from its customers -- and that they will take their money somewhere else.
Hey Michigan! It's time to take some action! Occupy Wall Street! Protest Bank of AmericaSubmitted by Steering.Jim on Mon, 10/03/2011 - 02:07
Ladies and Gentlemen,
It's time to stand up and make a statement! While the world is taking action to put Wall Street on notice through the Occupy Wall Street Movements, Bank of America has put it's customers on notice that they will be paying debit card transaction fees. Allegely they claim it's due to the new regulations placed on them.
I think it's time to tell Bank of America we're moving our money to local Michigan banks and credit unions. Make a sign and stand on the public sidewalk in front of your local Bank of America branch. Take a picture or video and post it on Youtube. Show your solidarity with the folks who are Occupying Wall St. Get with the program Michiganders. Put Bank of America on notice. We are the customers! We like our regulations and we will not pay more money to you because you want revenge on the Democrats/politicians who stood up for the American people. Together we can put Bank of America on notice. It's time they downsize and cut their CEO pensions and benefits and start treating us like the customers we are.
Watch the inspirational video here: http://www.occupytogether.org/
We can make a difference.
Steering Jim
Ask Senators Levin and Stabenow to encourage a Senate Judiciary Committee investigation Justice Clarence ThomasSubmitted by Steering.Jim on Mon, 10/03/2011 - 01:46
I would like to encourage all readers of our site to write your Senators and encourage an investigation by the Senate Judiciary Committee into the actions of Clarence Thomas. Please see the letter that I have sent below. Adapt the message to your own needs.
Dear Senator Levin,
I know that you must be aware of all the impropriety that has been uncovered about Supreme Court Justice Clarence Thomas. He is a national disaster. He has debased the Supreme Court with his utter disregard for common standards of ethics and integrity.
While I don't think you serve on the Senate Judiciary Committee I thought you might encourage Senator Patrick Leahy for me to conduct a full investigation into Clarence Thomas' misconduct.
In case you have not had time to follow the news, Thomas attended a retreat for rich conservatives organized by the Koch brothers, then supported a Supreme Court decision that benefitted the Kochs. For five years he failed to report, as required, the $687,000 his wife was paid by the conservative Heritage Foundation. A Georgia museum that's a pet project of Clarence Thomas took a multimillion dollar gift from the conservative funder Harlan Crow. The list goes on...
Happy Halloween! The Theatre Bizarre, DetroitSubmitted by Steering.Jim on Mon, 09/19/2011 - 01:51
Hello all,
I thought I'd take a few minutes to wish you a Happy Halloween season. For those of us living locally we all know Detroit has some awesome things to offer. One of the most liberal and awesome spectacles in all the world can be found right here in Detroit for just one Saturday night each year! While previously an awesome outdoor spectacle, this year it will be held in the Masonic Temple and its related properties.... it's HUGE.
Be sure to attend! You will not regret it! A don't forget it's Costume Mandatory!
Let the show begin!
Steering Jim
How the GOP Stole the Ohio Election in 2004Submitted by Steering.Jim on Wed, 08/24/2011 - 03:00
Ever since Bush/Cheney's re-election in 2004, there's been an ever-growing body of strong evidence that their "victory" was stolen. Before that year was out, there was the Conyers Report—a powerful study that the US press, both corporate and left/liberal, all but totally ignored.
Those early findings were confirmed and amplified in many works appearing through the next few years, including Robert Kennedy's landmark article in Rolling Stone, "Was the 2004 Election Stolen?"; Richard Hayes Phillips' WITNESS TO A CRIME, his massive "audit" of the vote in 18 Ohio counties; the several works, all indispensable, of Bob Fitrakis and Harvey Wasserman; Steve Freeman's WAS THE 2004 PRESIDENTIAL ELECTION STOLEN?(co-authored with Joel Bleifuss), a thorough vindication of the exit polls that told of Kerry's VICTORY in Ohio (and ten other states); and my own book FOOLED AGAIN. And there's been further evidence in documentaries like Dorothy Fadiman's STEALING AMERICA: VOTE BY VOTE and Tom O'Brien's COMMANDER 'N THIEF, among others.
The Republican Values: Welfare for the WealthySubmitted by Steering.Jim on Wed, 07/20/2011 - 00:19
For all the mouthpieces in the Republican party who denounce welfare, "government handouts", "entitlement programs", and socialism which help to keep the poor, working poor, elderly, and disabled alive, they have no problems with raiding taxpayers of billions of dollars as soon as they are in office with corporate welfare programs. Everything from the farm subsidy programs to tax breaks for the wealthy, caps on social security taxes, subsidies for Big Oil, Wall Street Bailouts, Banking bailouts, and on and on and on... the cycle just keeps happening as long as Americans keep voting Republican. Wake up America is not even strong enough a statement these days!
Stop the Republican Raid on Democracy! Protect your tax dollars and your country! Vote Democratic every single time!
Steering Jim
Voter Suppression - The Name of the Republican Game for Defeating Obama in 2012. It's at work in Michigan and everywhere!Submitted by Steering.Jim on Wed, 07/20/2011 - 00:13
From McClatchy news, an excellent source for facts. The opening statement in te quoted article is blunt:
It should be clear to all but the most steadfast of reality deniers that the strategy of the Republican Party for the presidential election next year is to cause another recession and hope the voters blame President Obama.
Read more: http://www.mcclatchydc.com/2011/07/18/117704/commentary-keeping-some-vot...
"...In the case of African Americans, it would be hard even for Rove to argue that Obama is a racist. So another tactic is employed. Republican state legislatures around the country are as busy passing voter identification laws as they are dismantling the rights of labor unions. Democratic legislators are trying to block such measures.
Do Republicans feel passionately about voter fraud while Democrats don't care? No, but the fact that cases of voter fraud are harder to find than Rockefeller Republicans these days explains why there is such a partisan divide on the issue. The real purpose of such laws is to discourage poor and/or black voters from going to the polls and voting for Democrats.


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The 2012 District 6 girls singles tennis championships featured a pair of first-time winners. For one, it was her last chance at district gold. For the other, it may be the first of more to come.
Altoona senior Ashli Livermore defeated Hollidaysburg's Marissa Lanzel, 6-3, 6-1, to capture the AAA title, and Central Cambria freshman Hannah Swope knocked off Tyrone's Ana Hollen, 6-2, 6-1, for the AA crown Saturday at the ProCare Health and Fitness Center.
For Livermore, it was a sense of "relief" to break through and win the district championship after finishing runner-up to Hollidaysburg's Mariah Turiano a year ago. She also finished runner-up in the doubles championships last year and three years ago as a freshman.
"I worked really hard to get back to this match and finish it off this time," Livermore said. "I wasn't as aggressive as I could have been last year. I didn't want to walk away this year regretting that I didn't do something I should have done."
Despite not playing quite as aggressively early on in the match, Livermore jumped out to a 3-0 lead in the first set, but Lanzel won three of the next four games to fight her way back into the set.
Livermore won the next two games to close out the first set and went on to take the second set for the title.
"I got a little more aggressive mid-first set, and kept my foot on the gas pedal in the second set," she said. "I didn't want to let up because when I do that's when I start to struggle."
Lanzel had some success hitting to Livermore's backhand and getting her on the run, but it wasn't enough to overcome Livermore's consistent shot placement.
"Marissa played about as well as she could have played," Hollidaysburg coach Brian Denis said. "The final score didn't indicate how tight the match was. Almost every single game went to deuce."
Livermore is Altoona's first district singles champ since Olivia Walton won back-to-back titles in 2006-07.
"Ashli got the big points when she needed them. It was a highly-contested match. There were a ton of deuces," Altoona coach Eric Hovan said. "I don't think I've ever been happier for one of my players. She's worked so hard. It wouldn't have seemed right if she graduated without winning."
As Livermore's high school career winds down, Swope's is just getting started.
A good mix of shots served the Central Cambria freshman well in the championship match. A strong forehand combined with lob shots and varying spin on the ball kept Hollen on the baseline and off the net.
"I like playing at the net, but she kept me deep a lot," Hollen said.
Up 3-2 in the first set, Swope swept the final three games to take the opening set and dropped just one game in middle of the second set to wrap up the title.
"I was nervous at first, but once I shook that off, I played my game and started mixing the pace of my shots," Swope said.
Like in AAA, the match was closer than the final score would indicate with many games going to deuce and a number of long volleys.
"The one point must have gone back and forth 40 or 50 times," Tyrone coach Mike Hample said. "Ana played very well. There were a lot of deuce and ad points that could have gone either way."
Hollen is already looking ahead to next year, thinking about a possible rematch.
"I didn't put a whole lot of time in before the season, and I paid for it now," she said. "It's a hard lesson to learn. I'll focus on it more and come back again next year."
The finals matchup was a bit of an odd pairing in that neither school the two attend has a girls tennis team.
Hollen, who is a sophomore at Bellwood-Antis, plays on the Tyrone team as part of a co-op between the two schools. Swope hones her game through clinics, lessons, and various tournaments. She also runs cross country for Central Cambria.
As district champions, Livermore and Swope qualify for the state championships starting Nov. 2 in Hershey. Livermore is slated to play the District 1 fourth-place finisher in her opening round match. The AA bracket has Swope facing the District 11 champion in her opening match.


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Top Definition
Short for "women's soccer." Often written as "WoSo" but sometimes just as "woso." Pronounced woe-soe.
The U.S. women's national team has a game on Saturday night, UNC is playing Notre Dame Sunday afternoon and then I am going to see the Portland Thorns play the Boston Breakers. This is going to be a serious WoSo weekend!
av adsdasadsaasd 27. september 2013
Trending Now
Can you define these popular missing words?
When located in an area where there is no service and all of the sudden you gain service
WoSo a combination of Wooo Hoo and Woo Service
av Catia 2. mai 2004


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Color guard teams from Summerville and Ashley Ridge high schools begin competing today for world titles in the 2013 Winter Guard International World Championships in Dayton, Ohio. The event continues through Saturday.
Winter Guard is a color guard competition held indoors without the marching band, said Ben Hipp, director of the 18-member state champion Summerville Winter Guard team that is representing the school in the worlds for the 10th straight year. They compete in the Scholastic Open division.
Ashley Ridge's 10-member team, competing in Scholastic A class, is going for the first time. The two teams traveled together to Dayton. Both teams qualified through performances in regional competitions held in Raleigh and Richmond, Va.
Hipp said he is excited to be joined by Ashley Ridge's color guard, which is directed by his childhood friend, Jessica Hinkel.
As many as 500 teams compete in the Winter Guard World Championships. Summerville has finished as high as 10th place (15 teams make the finals), and finished 17th several times, missing the finals by two-tenths to four-tenths of a point.
"Winter Guard is just the color guard ... the flags, the rifles, the sabers, the props. We use pre-recorded music," said Hipp, who has been with the Summerville program for the past seven years. "You will hear everything from Bach and Beethoven to Top 40 music, depending on the group's program and concept. It's supposed to be the artsy side of marching band."
Hipp said the marching band and color guards work together through football season, performing at games and in competitions. When marching band ends, the squad takes a few weeks off before planning its Winter Guard show.
Hipp said the Summerville show is titled "My Love" and is based on the music by Sia from the "Twilight" soundtracks. He said it was inspired by a faculty member whose grandmother had been sick and passed along a box of old letters from her husband.
"We all felt this was a story we had to tell. We had (color guard members) go out and talk to their grandmothers, great-grandmothers and aunts and get them to share a letter so they would have their own emotional attachment to this project," Hipp said.
"It's a sepia photo that comes to life throughout the show. Our hope is that we leave you with a warm, comfortable feeling when the show is over, that you've been through an emotional journey."
Hinkel said Ashley Ridge's show, "Both Sides Now," comes from the Joni Mitchell song and plays on the idea of both sides, the beginning and end. There are two shades of costumes, and it is a pretty show, she said.
"It's kind of a coming out party for us. It's exciting to go for the first time, and we're really looking forward to it. It will be a wonderful experience for our team," said Hinkel, who has been to the event herself but not with Ashley Ridge.
"Seeing their reaction to being there for the first time. It's such a huge event, and to get to watch and see all those groups. I would like for us to have a great performance in preliminaries and see if we are able to get into the semifinals."
Ashley Ridge's color guard team competes in the Scholastic A class in the Winter Guard International World Championships in Dayton.×


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Top Definition
Thats totally Blon
de PattsyB 28 juillet 2011
Trending Now
Can you define these popular missing words?
This word was created in Bristol (UK) and is used to mean Blaze On! it can be used many ways but ultimately as a way of asking a person if they are interested in smoking a large reef or many large reefs
yo man Blon?
hell ye man Blon Blon Blon!!
hell ye man Blon Blon Blon!!
de bristols finest kush 7 novembre 2011
the scottish word for shorty
faz ur blon noo then?
de Super F.L.I. 8 juin 2006


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Audie Award Nominee, Original Work, 2013
Six months ago, the world ended. The Baugh Contagion swept across the planet. Its victims were left twitching, adrenalized cannibals that quickly became know as Junkies. Civilization crumbled as people created isolated safe havens to hide from the infected... and the possibly infected. Now, as society nears a tipping point, lives will intersect and intertwine across two days in a desolate city.
The Junkie Quatrain is four tales of survival, and four types of post-apocalypse story, because the end of the world means different things for different people. Loss. Opportunity. Hope. Or maybe just another day on the job.
©2012 Peter Clines (P)2012 Audible, Inc.
Two great passions - dogs and books! Sci-fi/fantasy novels are my go-to favorites, but I love good writing across all genres.
"An awesome set of vignettes"
Just finished The Junkie Quatrain - didn't finish the laundry (thanks Peter!) because I was so engaged by these stories - and I am sitting here a bit awe struck. I'm not a huge monster fan especially the zombie type monsters with no individuality. But I picked up The Junkie Quatrain on sale because I enjoyed 14 so much and I am so glad I did. Nothing special about these monsters but there is something pretty special about 4 tightly written monster stories that could each stand alone but each connects to the others in such clever ways. In quick strokes, Peter Clines defines each of the central characters so that you invest in them immediately and each of these shorts then delivers a lot of punch. Mr. Clines can certainly write and Christian Rummel and Therese Plummer each do nice narrator turns with the material. It's not that the stories themselves are too short - each is a perfect length and locks in with the others almost with a "snap". It's just that the "snap" each time is such a "AHA" payoff in the brain you want it to go on and on. It's like watching a great dancer do a few quick amazing moves on the dance floor and then walk away before you can quite grasp what you saw. I totally loved this set of interlocking vignettes!
Favorite author: Alexander McCall Smith Favorite narrator: Gerard Doyle Favorite listen : Burton and Swinburne Trilogy
"Get down in junkie town"
It is four stories about post apocalyptic California. At some point each story intersects.I love the way the story unfolds. You get information from different points of view so you learn more in each story Very entertaining. It was short so I listened to it twice so I could pick up on more things. I enjoy Peter. Clines. The narration was very good too.I bought it on sale I thought it was fabulous.
Avid Zombie fan who's starting to listen to more and more Fantasy and Sci-Fi stories. So, my description is apt to change. Dog lover who's known to have cats. LOL C# coder, part-time prepper, B movie fan, AMC watcher, recovering but successful day trader, perpetual student, overjoyed uncle, former adrenaline junkie with a flare for cooking, and lots more. LOL
"a sneeze that never comes"
wish there was more! the 4 short stories are great. they weave together seamlessly. my disappoint is the clines could've made a full-blown book out of this material. the stories are great, but they just end. there's no resolution. the stories end just as the characters begin to reveal themselves. i was left frustrated, wondering what happens next. it's like clines wrote 1/3 of a book then just quit. i really hope clines publishes more, continuing the stories he started. i kind of feel cheated that it just ended! however, i sure did enjoy the ride while it lasted! it's like a rollercoaster- i was thrilled listening to the audiobook, but when it was over, i wanted to keep riding.
Each story has an interesting character. Each story reveals part of the overall plot- what has happened, how it has affected the world, and how different types of people have survived. Clines builds an interesting world that longs to be explored. We get just enough to start salivating, but he leaves us wanting more. Lots of potential.
so if you've got a few hours to burn, listen to these short stories. they're better than everything in the movie theaters and on the tube right now.
The Junkie Quatrain by Peter Clines narrated by Christian Rummel and Therese Plummer. I just listened to this one last night in one sitting. I have really enjoyed branching out into the post apocalyptic zombie books lately. That being said there are good ones and bad ones. This book was really good. I would love to see it turned into a series or at least a full length novel. The narration is great and the stories flow and intertwine easily. This is one of the books that leaves you wanting more. I would recommend it to anyone looking for an entertaining quick read.
DOOP Philadelphia Union DOOP
"Dear Peter Clines,"
Write faster!!! I've listened to all your books so far. This one might be my favorite. So please, WRITE FASTER!!!
"I'm okay. The rest of the world? Not so much."
I love Clines Ex-Heroes and Ex-Patriot novels (both awesome reads/listens), and decided to give the Junkie Quatrain a listen.
I'm glad I did! This is an apocalypse novel that has all the right elements to keep me listening. Good concept and delivery. Characters in whom I want to invest. Descriptive settings and direction. Good action sequences. Solid writing. And my favorite - engaging. Once you've engaged a listener, and KEEP them engaged, you've won.
Most apocalypse novels far short on all these, but Clines did this in the Quatrain superbly. One of the simple but brilliant concepts was to have these stories connect, so we see difference perspectives on the shared event. That's thinking out of the box as a novelist. Simply put, this is good writing for the genre' and I highly recommend it.
This apocalypse is based on a virus that reduces the infected carrier to a muttering, sometimes screaming, violent and animalistic maniac. Scientifically more believable than reanimated flesh, I'd say. So, it adequately suspends dis-belief. Only the sane survive, but barely, as the world becomes one large sanitarium for the utterly mad and canniballistic. Hey, it could happen!
This is escapism at its purest level. No big lessons here. Just gold old-fashioned adventuring. At times we NEED an adventure, and Clines definitely delivers in the Junkie Quatrain, as well as his other works, to which I've re-listened, catching nuances I missed in earlier listens.
I have only one complaint - Why, oh why, can't this be a full length novel?
Clines, get busy, and give us more!
1*=I didn't like it..... 2*=It was OK...... 3*=It was good but I will never read it again.......... 4*=Maybe I will read it again in the future.............. 5*=I will definitely read it again(maybe more than once)
"Great story !!!"
Great story.
I just want to point out 1 fact.
How can russia report 300 million dead, while it's population as of 2011 is 141.5 million.
Everything else is great.
"Classic Peter Clines"
If you enjoyed his other books, you will definitely enjoy these four short interconnected stories by Peter Clines. I definitely recommend for any Peter Clines fan looking for some solid and engaging entertainment.
"Leaves you wanting more"
This book is short and sweet, but leaves you wanting more. I didn't read the description before I started listening so when the first vignette ended, I was confused, but quickly found my bearings again. There are four stories which all overlap somewhere.
The world ended 6 months ago, disease spread across the earth, creating "adrenalized cannibals" called Junkies, and our story follows four groups as they travel to find safety without becoming infected.
"It's been agony, but I couldn't have done it any other way." - Quentin Crisp
"Pleasantly Surprised"
I bought this sort of spontaneously as a deal of the day or something like that. I assumed it would be sort of rubbish, but ultimately it was a pleasant enough way to spend a few hours. This isn't the type of book I typically read, but I have to say I wouldn't mind reading similar books more often...
"Not a bad zombie story."
A great set of stories that build up and link together. I would have like the stories to have a little more depth, there is definitely scope for longer stories or a second book.
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If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


text:
on December 2, 2012 - 3:15 PM
Ferry-Fillmore District police said a convenience store at 155 Jefferson Ave. was robbed by a gunman between 8:20 and 8:40 a.m. today.
The clerk told police that the robber provided a bookbag and ordered him to open the cash register and place cash and coins into the bag. He also forced the clerk to place some cigarettes into the bag.
While the robbery was going on, the gunman kept pushing his pistol against various parts of the clerk's body, including his head, police said. He also stole the clerk's cellphone before leaving.


text:
on February 5, 2013 - 1:40 AM
Aug. 1, 1930 – Feb 3, 2013
Alice M. Pytak, a Lackawanna freelance writer and part-time secretary, died Sunday in Fox Run Nursing Home, Orchard Park. She was 82.
Born in Buffalo, she was a local freelance writer and was published in regional and national publications, including Reader's Digest. She specialized in local and regional historical pieces, and her writing appeared in the Sunday magazines of The Buffalo News and the Courier-Express, and the Catholic Digest. She also wrote a history of Our Lady of Victory Basilica, which was popular with tourists. She was a member of the National League of American Pen Women.
The former Alice Pientka was a graduate of Villa Maria Academy and Empire State College. She was a longtime member of Our Lady of Victory Parish, where she sang in the choir for more than 30 years. She also was a tour guide at the basilica for many years.
Her husband of 51 years, Richard, died in 2011.
Survivors include two sons, Richard and David, and two daughters, Mary Hageman and Linda Mendola.
A Mass of Christian Burial will be offered at 9:15 a.m. Wednesday in Our Lady of Bistrica Croatian Catholic Church, 1619 Abbott Road, Lackawanna.


text:
Mac Apps: iAntivirus, TextWrangler, Chrome, Freeway
Here we are at the end of the week facing down a "short" weekend. Well, at least we can count on Mac app updates. So, let's get hot people and then dig into feature, tweak and fix rich updates for iAntivirus, TextWrangler, Chrome and Freeway.
• iAntivirus 1.1.3 (free, Mac App Store)
— More compact delivery of virus definitions
— Improved quarantine interface
— Faster compressed file scanning
— Updated virus definitions
For what it's worth, iAntivirus ranked near the bottom of the Fairer Platform's look at the Best Mac Antivirus apps, scoring near the bottom of the table at detecting known Mac malware.
• TextWrangler 4.5 (release notes)
— A significant feature update which includes support for Macs with the high-resolution "Retina" displays, assorted new features, and fixes for reported issues.
TextWrangler is the love child of Bare Bones Software, which also makes BBEdit. Good apps, good peeps.
• Chrome 25 (blog)
— Updated Flash to 11.6.602.169
— HTML5 Content Decryption Module (CDM) with WebM support
— Fix to Samsung Chromebook device freezes or crashes on some systems when trying to resume after suspend
— Extended Desktop Mode (multi-monitors) now supported
— App Launcher now supports re-ordering
— More
Version 25, really? Haven't used Chrome in over a year (too janky), but keep a copy around just 'cause. How about you?
Lastly, the good folks at SoftPress have released Freeway Pro 6.0.3 and Freeway Express 6.0.3 updates, which deliver bug fixes.
Related posts:
— Mac Apps: Flip4Mac, Tweetbot, Acrobat, Java SDK
— Java for Mac OS X Updated for Snow Leopard, Lion, Mountain Lion
— What's New in iTunes 11.0.2
— Songbird 2.2 'Integrates' AmazonMP3 Store
— Firefox 19 Integrates PDF Viewer, Boosts HTML 5


text:
1:08 minutes
Are you in extreme danger? Need special security? Is there a bullet out there with your name on it? Leave it to Chance. Mark Valley is protector-for-hire Christopher Chance in the thrill-packed 12-Episode Season 1 based on the DC Comics series and graphic novel. From piloting a distressed, upside-down jumbo jet to bodyguarding a D.A. targeted by a gang, Chance puts his life on the line, and each new adventure reveals a little about the mysterious past that drew him to this line of work. Chi McBride as ops manager Winston and Jackie Earle Haley as techno genius/fixer Guerrero are Chance\'s ace support crew in a series bursting with \"brilliantly off-kilter characters and high production values\" (Mary McNamara, Los Angeles Times).


text: Evaporative coolers offer a few environmental benefits. Mainly, evaporative coolers use a relatively low amount of energy to cool your home. In fact, they use between one-tenth and one-third of the energy that air conditioners use. As a replacement for AC, coolers can help to curb your home's overall greenhouse gas emissions. In addition, evaporative coolers don't use ozone-depleting chemicals. Evaporative coolers are also a fairly quiet method of cooling. Nevertheless, some evaporative coolers use a large volume of water to operate, especially if they have a bleed line. You can reduce the amount of water used and lessen the environmental impact of your evaporative cooler by looking at the Best Ways to Save & Drought Tips page.


text:
The two stars, whose brief relationship fizzled in December, arrived quietly together on Wednesday at Bound'ry, a restaurant near Swift's Nashville condo, and were led back to a table for two, according to another patron.
"They did eat," the patron tells PEOPLE. "They were cordial to one another, but not affectionate."
And another source tells PEOPLE that they seemed friendly. "There was no holding hands, but they seemed happy together," the source says. "They sat next to the fireplace just chatting away."
The two were last spotted publicly together on Dec. 9.
Swift has been lying low in Nashville in recent days, rehearsing with her band for a concert on a Royal Caribbean cruise ship, where she will perform on Friday, and for the Asian leg of her Speak Now tour, which begins in Singapore on Feb. 9.
See what other readers have to say about this story – or leave a comment of your own


text:
robot's name is Spike. It has many different options and can get
around easily.
Space Pet Involving Kinetic Energy (acronym for Spike)
1) Made out of billet aluminum reinforced with Kevlar and heat resistant
rubber. Also, Heli-Arc welded
2) Has top propeller with two side propellers for steering
3) Rubber bottom tripod for standing position, and swivel ability and
wheels attachments
4) Solar panels for energy
5) "Food" box for recycled energy to charge battery pack.
6) Speaker to receive voice commands and to relay information
7) Satellite dish to transmit information back to receivers at NASA
or other places
8) Two camera lenses to take still and motion pictures
9) Infrared sensors and motion sensors
10) Monitor billboard of world news headlines happening on Earth
11) Right "hand" has finger attachments: knife, drill, plug-in
wire to access computer mainframes, and screwdriver (Philips and flathead).
"Hand" can also pick up objects, for finger attachments
are retractable
12) Left "hand" is a powerful vacuum to also pick up and
identify objects
13) Compartment to hold vacuumed objects
14) A freezer to hold cold objects
15) Heater to hold objects that need to stay warm
16) Laptop to control robot programming and to view what is in the compartments
17) A built-in outlet for robot to be plugged in
Spike looks like a three-foot tall half oval solid figure, and it could
be any color. They can talk to it by typing in the laptop and giving
voice commands through the speaker. This robot uses propellers to help
steer itself through the floating, low gravity atmosphere of the ISS.
This robot can also help fix things; it can hold and help identify objects.
On the ISS Spike could make stuff easier for the astronauts by telling
them information, being a portable transmitter, and helping with their
daily needs of maintenance and storage. We can tell this robot from
others, because of its shape and many attachments.


text:
Today is no ordinary Thursday. The date, June 23, marks two years since six companions and I returned from a road trip along South Africa's southern coast, stretching from Mossel Bay to Storms River Village—a span of roads and towns along South Africa's N2 known as the "Garden Route." To where we returned was South Africa's Mother City, Cape Town, which is now hosting First Lady Michelle Obama, an event of no particular significance to, well, probably anyone reading this.
For me however—thanks to a timely tweet from @BigIssueSA—this means a great deal, as Michelle Obama apparently stopped at The Kitchen for lunch. The Kitchen, the home of the finest chicken sandwich in Woodstock, a suburb of Cape Town. And, of course, the greatest lunch stop in Woodstock, since it is just up the block from the offices of The Big Issue: South Africa magazine, where I worked from May to August 2009.
I would remiss to not point out that, whatever your opinion of President Obama and his policies—and therefore, whatever opinion you hold of his wife—the image of the United States' first black First Lady walking around a nation just 17 years removed from apartheid and its first democratic elections is one simultaneously striking and poignant. (Now, if we could just convince Julius Malema that arbitrarily seizing and redistributing farmers' lands is one of many factors that led to Zimbabwe's ruin…)
As from here on out, I'll dedicate this post to Alex, Kuba, Whitney, Riley, Robert, and Dave.


text:
EDITOR'S NOTE: The Post and Courier plans to profile all 18 Republican and Democratic 1st Congressional District candidates by the March 19 primaries. This is the 11th installment.
Elizabeth Moffly
Birth date: March 10, 1961Education: Attended Queens College and the College of Charleston.Occupation: President, Moffly Construction and Real Estate.Previous offices held: Charleston County School Board (2010-present)Family: Married, David; four children.Why I'm running: "I'm running as an advocate for District 1. For me, it's about constituent service and learning who I work for. I do understand large, centralized government bureaucracies are eroding our freedoms and bankrupting our country."Proudest accomplishment: "I love my family and am proud they're supportive of my advocacy for the general population."Contact information: mofflyforcongress.com; firstname.lastname@example.com; 843-296-6937.
Key dates
March 19: Republican and Democratic primariesApril 2: Primary runoff (if needed)May 7: Special election
Elizabeth Moffly's entrance into politics took root after a lively conversation following a PTA meeting — one that led her husband to get out of their car and slam the door.
Moments before, the mother of four had been voicing her displeasure with mandates at her 10th grader's school.
As her husband left her alone in the car, she recalled, "He asked me, 'What are you going to do about it?'"
Her answer ultimately would lead to her waging two unsuccessful campaigns for S.C. Superintendent of Education and a successful bid in 2010 for a Charleston County School Board seat.
Today, Moffly is one of 16 Republicans setting her sights on the 1st Congressional District seat vacated when Tim Scott was appointed to the U.S. Senate.
"It's random, but you do things because you're upset," Moffly said of her political involvement, "and you've got something today and nobody is doing anything about it."
If Moffly began her political career because of frustration with schools, she has fed it with frustration with Congress. "I just see a lot of things going wrong with
If Moffly began her political career because of frustration with schools, she has fed it with frustration with Congress. "I just see a lot of things going wrong with what is going on in Congress," she said.
If elected, she said she would push to audit each federal agency and focus on core functions like national defense and infrastructure. She also would push to bring more free enterprise and competition into the nation's health care system.
She also said her approach would be less, not more. "Laws are made for honest people," she said. "More laws only make it harder for honest people to get something done."
She said she believes in term limits.
Moffly said her knowledge of education sets her apart from the GOP field, though she has not advocated abolishing the U.S. Department of Education, like some of her primary opponents have.
She said she dislikes RINOs (Republicans in Name Only), but she broke ranks in 2006 to endorse Democratic superintendent candidate Jim Rex, who ultimately beat Republican Karen Floyd.
Moffly noted she has Scotch-Irish roots that make her independent, and she was upset that then Gov. Mark Sanford (who is now one of her 15 primary opponents) endorsed Floyd. She called the move "a punch in the nose."
Henry Copeland, an outspoken critic of the Charleston County School Board, said he supports Moffly, in part because she has done her homework in her current school board role and partly because she's female — like the Democratic frontrunner, Elizabeth Colbert Busch.
"I think we need a woman in Congress," Copeland said. "I can't think of anything better than seeing two Elizabeths in the final election."
Moffly said being a woman does give her a different perspective. "If it wasn't for the women of this party, there wouldn't be a party," she said.
Reach Robert Behre at 937-5771.


text:
LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
Developers of DTC Genetic Testing Are...
A potential avenue for therapeutic intervention is kinases linked to abnormal phosphorylation of tau, which is implicated in Alzheimer disease. [Andrea Danti - Fotolia.com]
Protein kinases (PK) have provided drug targets that have yielded innovative and highly effective therapeutics for cancer treatment. These include small molecule PK inhibitors such as Novartis' Gleevec, Pfizer's Sutent, GlaxoSmithKline's Tykerb, and Bristol-Myers Squibb's Sprycel. PK inhibitors now comprise over 30% of most major pharmaceutical companies' pipelines. By 2020, small molecule kinase inhibitors are expected to collectively generate annual revenues of over $25 billion.
The success of kinase inhibitors in cancer has spurred research to develop similar compounds for other diseases including neurodegenerative disorders. But how close to the clinic are kinase inhibitors for central nervous system (CNS) diseases? Noscira has one drug candidate that is in Phase II for supranuclear palsy and is also ready to enter mid-stage trials in Alzheimer disease (AD).
Plenty of basic research, however, is being conducted. As the significance of kinases in the molecular pathway of neuronal survival becomes more apparent, multiple different key pathways are being described, leading to a plethora of potential targets.
Pathways of interest for CNS diseases "include apoptotic and necrosis pathways as well as pathways involving inflammation since this is also a factor that exacerbates cell loss in neurodegenerative diseases," Marcie Glicksman, Ph.D., co-director of the lab for drug discovery in neurodegeneration, Harvard NeuroDiscovery Center, told GEN.
Dr. Glicksman further noted that other kinase-regulated dysfunctional pathways including mitochondrial dysfunction, protein misfolding and aggregation, as well as abnormal RNA processing may all be fair game as viable drug targets for neurodegenerative disorders.
Another potential avenue would be kinases involved in abnormal phosphorylation of tau, which is linked to AD. Additionally, mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) that are known to lead to Parkinson disease (PD) are also viable target candidates, Dr. Glicksman reported.
Aggregation of hyperphosphorylated tau characterizes neuropathological lesions in diseases like AD. Recent studies support that disease-associated changes in soluble tau, including phosphorylation, occur relatively early and are involved in the induction of neuronal death.
Scientists caution, though, that while numerous reports have produced a huge amount of information about the activities of specific kinases on tau, the "identities of the true physiological and pathological kinases in vivo remain unknown." Several strategies to mitigate tau phosphorylation, including disaggregation of tau inclusions and tau immunotherapy, can be pursued investigators have remarked.
Phosphorylation reduction through inhibition of specific protein kinases, however, remains of interest to many scientists as a viable strategy. Inhibition of proline-directed protein kinases such as glycogen synthase kinase-3 (GSK-3) and cyclin dependent kinase-5 (CDK-5) have been studied in transgenic animal studies. Other candidate kinases impacting tau hyperphosphorylation that may serve as potential drug targets include the extracellular signal-regulated kinase ERK2, casein kinase 1.
GSK-3beta has been implicated in multiple cellular processes and linked with pathogenesis of and neuronal loss in several neurodegenerative diseases including Parkinson and Huntington diseases. Studies have shown that the enzyme's overexpression in transgenic mouse models results in increased tau phosphorylation and deficits in spatial learning. Inhibition of GSK-3beta activity leads to neuroprotective effects, decreased amyloid-beta production, and a reduction in tau hyperphosphorylation.
CDK-5, on the other hand, is required for the development of the central nervous system through regulation of neuronal migration. One of its activators, p25, is increased in AD brains where p25 and CDK-5 are co-localized with neurofibrillary tangles.
Several animal models have shown a correlation of p25/CDK-5 activities with tau phosphorylation. Overexpression of p25/CDK-5 in neuronal cultures not only leads to tau phosphorylation but also cytoskeletal abnormalities and neurodegeneration.
Noscira is the only company with a clinical-stage kinase inhibitor for a neurodegenerative disease, however. Its candidate, a small molecule GSK-3beta inhibitor called tideglusib, has orphan drug designation in the EU and fast-track status in the U.S. Last October Noscira said it had completed recruitment for its Phase II trial in supranuclear palsy.
In Alzheimer disease Noscira received approval in April to begin a Phase IIb trial. The company says that the compound has proven active against all of the histopathological lesions associated with the disease in experimental models: It reduces phosphorylation of the tau protein and hippocampal and entorhinal cortex neuron loss, improves spatial memory deficits, and reduces the accumulation of amyloid plaques in the brain. It also provides neuroprotection in vivo and has an anti-inflammatory effect in a range of animal models, the firm adds.
A Phase IIa trial in Germany was completed in early 2010. It was designed with the primary goal of assessing the safety and tolerability of the molecule. The company reported that the drug was well tolerated and had "a positive effect on patients' cognitive performance", although the results were not statistically significant "due to the small sample size and short treatment period."
Besides tau another approach for kinase inhibitor development for neurodegenerative diseases is targeting LRRK2. As of February 2010, The Michael J. Fox Foundation for Parkinson's Research had invested nearly $17 million to drive related initiatives at every stage of drug development. First linked to PD in 2004, mutations in the gene LRRK2 have recently been associated with autosomal dominant, late-onset PD that is clinically indistinguishable from typical, idiopathic disease.
LRRK2 is a multidomain protein containing several protein interaction motifs as well as dual enzymatic domains of GTPase and protein kinase activities. Disease-associated mutations are found throughout the multidomain structure of the protein. Researchers say that LRRK2 is unique among PD-causing genes because a missense mutation known as G2019S is a frequent determinant of not only familial but also sporadic PD.
The recent development of a compound that can selectively inhibit the kinase function of LRRK2 may enable scientists to more directly investigate the role of this protein in cellular systems, including which other proteins it may modify. Although unlikely to provide a therapeutic option for PD because it doesn't cross the blood brain barrier, the molecule will help provide information about cellular pathways triggered in nonfamilial forms of PD pathogenesis as well.
While only one kinase inhibitor targeting neurodegenerative disorders has reached the clinic to date, vast efforts to sift through relevant pathways and identify inhibitors of kinases thought to be involved in these diseases are under way. It is hoped that this basic research will give way to preclinical development and eventually testing in humans, but that's a fairly long way off.
Patricia F. Dimond, Ph.D. ([email protected]), is a principal at BioInsight Consulting.
Patricia F. Dimond, Ph.D. ([email protected]), is a principal at BioInsight Consulting.
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text:
(based on 3 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Reviewed by 3 customers
Displaying reviews 1-3
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Beautiful folio and excellent customer service!
By Newton
from Undisclosed
This is a beautiful folio and very functional. The leather is of the quality I expect from Levengers, and the magnetic hold is quite strong. I'm thrilled with my purchase.There was an issue after shipping - the package was stolen from my front porch - and when I called Levengers to re-order, the customer service agent was incredibly helpful and kind. She quickly reordered the item and sent it overnight so I could receive it without delay. I was overwhelmed by the level of customer service. I have been a Levengers customer for years, and this had made me that much more loyal.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Good hybrid product
By jessy
from Atlanta, GA
I try to be a purse content minimalist, but there are still some instances where I need to carry both my iPad and my Circa notebook. This folio does the trick in a professional and stylish way.I have an iPad original, so other Circa iPad products didn't really work for me, but I don't know that I would've chosen them if they had. I wanted something that looked sleeker than the foldover version and other versions held only non-letter and non-Circa notebooks.Yes, this is a little on the large side, which makes it a little surprising that it only holds 3/4" discs. I would've preferred it hold 1" discs, but then again I think that's an ideal size and it likely would've increased the folio's footprint. I actually think some minor modifications to it might decrease the size of the folio while maintaining functionality. Additional pockets might even increase functionality.The leather is smooth but not delicate and the suede on the inside is indeed skid-resistant. The magnets are nice and strong. I am confident I'll get many happy miles out of this folio.
Too BIG
By Bridgeville
This product is great for the iPad.However it's Too Big for the Kindle Nook and ipad mini...One of the reason we love these products is because of their compact size....this Levenger product defeats this purpose.We love if you create a similar product with a smaller footprint
Bottom Line No, I would not recommend this to a friend
Merchant response: Thank you for your review. The Notabilia Leather iPad Folio may be a great fit. It's a couple of inches shorter in width and length. It does still hold your standard iPad as well. It's item AL1086, which you can type in the search bar on Levenger above. Let us know what you think. 1-800-545-0242.
© Copyright Levenger Company
2016. All Rights Reserved.


text:
Wooden Sheds
Shop by construction style
Current Promotions
Best sellers
6x4 Apex Overlap Wooden Shed
Features & benefits
- This classic type of construction is great value
- Square cut overlap construction helps water run off the building
- Dip treated and guaranteed against rot for 10 years
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Features & benefits
- High quality cladding construction
- Greater protection from wind and rain penetration
- Ideal for securely protecting and storing garden essentials
- Dip treated timber to protect the wood against rot and decay
Help & advice
Sheds buying guide
Dont know your Apex from you Pent? have no fear, our handy sheds buying guide has everything you need to know when buying your first shed.
How to build a wooden shed
You've finally got your shed, now lets help you build it.
How to build a shed base
A firm, level base should be the starting point for any shed or garden building. Read our helpful how to guide to show you how.


text:
Chicagoland Family Pet Expo
Next video starts in : 7 Play
Chicagoland Family Pet Expo
San Diego Police Release Video of Alfred Olango Shooting
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Chicagoland Family Pet Expo
Whether you own a pet or not, you can have a good time at the Chicagoland Family Pet Expo at the Arlington Park Racecourse in Arlington Heights.
2:42Now watching Up next
San Diego Police Release Video of Alfred Olango Shooting
Police fired on him after they say he assumed a shooting stance, they have now admitted that Olango was unarmed.
2:44Now watching Up next
Trump Goes on Early Morning Twitter Attack
The GOP presidential candidate took to Twitter early this morning to attack Hillary Clinton and former Miss Universe Alicia Machado.
1:26Now watching Up next
Calif. Police Release Videos of Fatal Shooting
Police have released two videos showing the fatal shooting of an unarmed black man by an officer in a San Diego suburb. Warning: This video contains graphic content. (Sept. 30)
0:53Now watching Up next
John Legend is loving life as a new dad
John Legend opens up about his baby daughter Luna's 'firsts'. (Sept. 30)
2:35Now watching Up next
East Coast Braces for Severe Weather
Heavy rains in the Carolinas have led to flooding as Hurricane Matthew, now in the Caribbean may affect the Atlantic Coast.
1:49Now watching Up next
Trump Gives Deposition in Celebrity Chef Lawsuit
The presidential candidate was sworn in to give testimony in a lawsuit he brought against Geoffrey Zakarian, who allegedly backed out of a deal after Trump's comments on Mexican immigrants.
2:02Now watching Up next
More Details Emerge in Hoboken Train Accident
Authorities have recovered on data recorder, but are not able to retrieve the front-facing camera due to structural concerns at the station.
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Sisters Annie and Robin Korkkie, who were found dead at a luxury resort in the Seychelles last week, died from acute pulmonary edema.
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Rosetta Spacecraft Ends 12-Year Mission
ABC News' David Muir reports the stories people are buzzing about.


text:
Top Definition
Locally "Famous" New Orleans Rapper known for his arrogant ways and controversal Gestures & Appearance. Hated on by many but still has a lot of strong supporters. Hate him or love him he doesn't care & the ppl who support him love that about him. He also throws poppin ass parties around the city.
"Yo that's Sk David"
- "Yea he's LivingtheSwagglife"
- "Yea he's LivingtheSwagglife"
od uživatele 504-Nθ 18. únor 2012
Trending Now
Can you define these popular missing words?
A teenage rapper from New Orleans. Commonly discriminated against because of his arrogant remarks and cocky demeanor. Even though his raps aren't bad his attitude is what makes people not like him, you'll either love or hate him. He has a blog where he posts everything on skdavid.com
whose Sk David?
check him out at skdavid.com
check him out at skdavid.com
od uživatele brownsnake01 27. červenec 2012


text:
20 things: Middle East conflict
POSTED: 12:49 PM PDT May 11, 2011 UPDATED: 9:32 AM PDT May 31, 2011
The conflict between the Israelis and the Palestinians is one of the world's most long-lived. Here are 20 things to know about these troubled lands.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms.


text:
Homeclick Coupons and Promo Codes
HomeClick is a one-stop shopping resource for all of your home improvement needs. A wide variety of inventory is available including all the products you need for home renovation and design. This includes, but is not limited to: kitchen cabinets, bathroom vanities, chandeliers, mirrors, sinks, and more. Whether you are updating your kitchen or bathroom, or looking to update any part your living space, look to Homeclick. Take a percentage off of your purchase with a Homeclick promo code.


text:
ASCLA Committees
ASCLA COMMITTEES: Serving on the Association for Specialized and Cooperative Library Agencies (ASCLA) committees is a wonderful way to develop, enhance or practice your leadership skills, and add your voice to shaping ASCLA's future. To see the full list of committees, please use the following link to access the page containing the committee rosters: Go to Rosters.
VOLUNTEER FOR ASCLA COMMITTEES: To volunteer for an ASCLA committee, go to the ASCLA Online Volunteer Form and fill out the appropriate form from the choices provided by the interactive form. Your data is accessed by the appointing officer via the membership database. Appointments are made in the spring for terms that begin after Annual Conference.
You must log in with your ALA membership ID number (or e-mail address) and password to access the complete roster information and the volunteer form.


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Lunch12noon - 3pm
Dinner6.30pm - 11pm
Dinner6pm - 11pm
CL3 Architects Ltd.
Kanko Kikaku Sekkeisha Consultants & Designers Ltd., Tokyo
3.30pm – 1am (Mondays - Fridays)
12noon - 1am (Saturdays, Sundays and Public Holidays)
688 rooms consisting of:
Rooms (LRF Designers Limited)
11am - 10pm
Fitness Centre
24 hours
Indoor Swimming Pool
5.30am - 10pm
11am - 11.30pm
11am - 11.30pm
5.30am - 10pm
5.30am - 10pm
Steam Bath
5.30am - 10pm
5.30am - 10pm
Babies (below 2 years) will receive:
Children (2 to 8 years) who are staying in-house, will receive:
Children (4 to 8 years) will receive:
The following items are
available on request:
Over the years, in addition to doing the community good through such initiatives as environmental protection, Kowloon Shangri-La, Hong Kong has been working closely with a number of local charitable organisations, providing financial assistance through guest donation programmes, arranging a series of charity visits to those in need, sponsoring venues for charity events and more. One of the hotel's long-standing beneficiaries is Christian Action.
The two-storey lobby has been home to the Shangri-La Valley murals since the hotel opened in 1981. Created and painted by British artist Malcolm Golding, the large murals illustrate a mythical kingdom amidst the scenic Tibetan mountains, with beautiful bird and flower features at the foreground. The concept of nine "dragon" hills that Kowloon is named after is incorporated into both of the murals through the "dragon clouds." (In Cantonese, Kowloon or Gao Lung literally translates to nine dragons).
64 Mody Road, Tsim Sha Tsui East, Kowloon, Hong Kong
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