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Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
Developers of DTC Genetic Testing Are...
Study will evaluate oligodendrocyte progenitor cell therapy in spinal cord injury. [© juggle33]
Geron will be able to start what it claims is the world's first human trial with a human embryonic stem cell (hESC)-based therapy now that FDA has lifted a nearly year-long clinical hold on the firm's IND application for its acute spinal cord injury therapy, GRNOPC1. The Phase I trial will evaluate the hESC-derived oligodendrocyte progenitor cell therapy in patients with complete American Spinal Injury Association (ASIA) Impairment Scale grade A subacute thoracic spinal cord injuries. The primary study endpoint is safety, but additional secondary endpoints will assess efficacy of the treatment in terms of improved neuromuscular control or sensation in the trunk or lower extremities, Geron points out.
Looking forward, Geron says once the safety of GRNOPC1 has been confirmed in this first patient population it will look to increase the treatment dose, enroll additional subjects with complete cervical injuries, and expand the trial to include patients with severe incomplete injuries classified as ASIA Impairment Scale grade B or C.
"Our goals for the application of GRNOPC1 in subacute spinal cord injury are unchanged; to achieve restoration of spinal cord function by the injection of hESC-derived oligodendrocyte progenitor cells directly into the lesion site of the patient's injured spinal cord," states Thomas B. Okarma, M.D., Geron's president and CEO. "Additionally, we are now formally exploring the utility of GRNOPC1 in other degenerative CNS disorders including Alzheimer's, multiple sclerosis, and Canavan disease."
GRNOPC1 comprises hESC-derived oligodendrocyte progenitor cells that published studies have shown demonstrate remyelinating and nerve growth stimulating properties that lead to restoration of function in animal models of acute spinal cord injury, Geron explains.
FDA placed a clinical hold on the IND for GRNOPC1 during August 2009 when it was found that in one preclinical study animals treated using GRNOPC1 developed a higher frequency of small cysts at the injury site than animals treated in previous studies. Geron subsequently developed new markers and assays as additional release specifications for the treatment and has completed a separate confirmatory preclinical animal study to test the markers and assays.
The firm's regenerative pipeline includes GRNCM1, an hESC-derived cardiomyocyte treatment in development for the potential treatment of heart disease. The product is currently undergoing large-scale animal testing. Geron is separately developing an hESC-based islet cell therapy GRNIC1 for the treatment of diabetes and is working with collaborators on a degenerative joint disease program based on the development of hESC-derived chondrocytes. The firm says its collaborators aim to start large-scale animal studies with the treatment during 2010.
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The Counseling Center's primary purpose is to provide psychological support to students as they pursue their academic and personal goals, and to enhance the quality of each student's experience at Oberlin. The Counseling Center is primarily intended for assessment and short-term counseling, with referrals to private counselors in the Oberlin area if necessary. The center itself is funded through tuition and services are free of charge, although students are responsible for the cost of any external services. The number of sessions varies and is discussed as part of the initial intake process.
At the Counseling Center you may discuss and explore freely, in confidence, any problems, feelings, or fears that are important to you. The ultimate goal is to help you grow in self-understanding, so that you can better cope with your immediate situation and with future decisions.
You will find our offices a short walk from the center of campus in the Professional Services Building at 247 West Lorain St., Suite D.
Same day walk-in crisis consultation hours:
Mon. & Tues. 11 a.m. - Noon
Weds., Thurs., & Fri. 1:30 - 2:30 p.m.
EXTENDED WALK-IN HOURS: Monday (4/4) and Tues (4/5) from 11:00am until 1:30pm and on Wednesdays (3/30, 4/6) Thursdays (3/31, 4/7) and Fridays (4/1, 4/8) from 12noon until 2:30pm.
If you feel you're in crisis, the Counseling Center will see you the same day during regular office hours (Monday through Friday from 8:30am to 4:30pm).
Please call 440-775-8470 to make an appointment or walk over.
The after-hours and weekends professional counseling phone line is another important resource. That service is also accessed through the Counseling Center's phone number, (440-775-8470) by selecting option 2.

subset: commoncrawl


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Top Definition
poor work, half-assed effort.
The plumber's slipshod repair fell apart within a day.
dari Laura Sabtu, 25 Desember 2004
Trending Now
Can you define these popular missing words?
lacking quality, cheap, sloppy, flimsy, created with very little thought or planning
The slip shod computer program not only didn't work, in some cases, it di the exact opposite of what was intended.
dari David R.W. Wadsworth Jumat, 28 Oktober 2005
1)Boring, tedious, crap.
2)Exciting, fun, awesome.
2)Exciting, fun, awesome.
That movie was so slipshod.
dari BackToNormal Kamis, 01 Juli 2004


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Top Definition
When a bunch of high-school seniors are on their senior trip and some guy gets paid fifty bucks to get crapped on in the face. Usually followed by the people watching having to serve a detention the day after they graduate, where they then get their diploma. deuce
This is the most disgusting, inhumane act of God I have ever witnessed, I wouldn't do this to a dog. - our superintendant after he found out
додав Adam 05 Грудня 2004
Trending Now
Can you define these popular missing words?
Annual party in Waterford Connecticut held by Roger "Deuce" Templeton, the most critically acclaimed lifeguard in the State Lifeguarding System. This party cannot be missed.
when is Roger's DEUCE FEST? July 3, this year!
додав Templeton Deuce 12 Квітня 2007


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Major in Theatre
As one of the top programs of its kind in the nation, our Conservatory of Performing Arts combines hands-on experience and rigorous training with internationally recognized master teachers, directors and choreographers. You will develop your craft working with these professional artists and leave with a resume full of experience in performance, stage-management, or technical theatre and design.
You will learn and perform at Point Park University's Pittsburgh Playhouse, a professional-caliber venue that is home to four companies: The REP (professional theatre company), Conservatory Theatre Company, Conservatory Dance Company, and Playhouse Jr. Not only will you become a part of the productions, but you will observe professional actors at work, on stage and behind the scenes.
Theatre Degrees Offered
Bachelor of Arts Degree
The B.A. in Theatre Arts: Performance and Practices is a self-designed program that:
- Provides a strong foundation in performance;
- Immerses students in theatre-making; and
- Creates opportunities for collaborations with other Conservatory of Performing Arts and University programs.
B.A. students have the option to pursue a minor, double major, study abroad and/or complete their degree in three years.
Bachelor of Fine Arts Degrees
Point Park offers rigorous B.F.A. degrees in Acting, Musical Theatre and Theatre Production that:
- Offer intensive training in stage performance;
- Prepare graduates for potential career options with professional acting companies, productions and associations; and
- Create collaborations with visiting artists in the classroom and production.


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AICPA News Update
A Weekly Email Newsletter on Issues & Events Surrounding the CPA Profession
November 11, 2011 - Volume 14 No. 48
The AICPA is urging CPAs to immediately send a comment letter to the Financial Accounting Foundation (FAF) to help make financial reporting more relevant and less complex for millions of the nation's businesses. CPAs are asked to respond to FAF's Plan to Establish the Private Company Standards Reporting Council, released on October 4 for public comment, and express support for the Blue Ribbon Panel on Standard Setting for Private Companies' recommendation that FAF create an independent board to set exceptions and modifications in U.S. GAAP for private companies. According to FAF's proposal, decisions of the new council would have to be reviewed and approved by the Financial Accounting Standards Board (FASB), which FAF oversees.
The AICPA believes the FAF proposal does not go far enough and that true differential standards for private companies would be better achieved through the Blue Ribbon Panel's recommendation – namely, that a board consisting of members with private company constituent experience and able to act on its own is necessary to make effective and efficient private company financial reporting a reality. A two-step, easy-to-use AICPA online tool enables you to send a letter in just 30 seconds. The public comment period closes January 14, 2012.
A high volume of comment letters is needed to change the course of FAF's proposal. Thank you in advance for your time and effort to finally bring true and lasting change to private company reporting after more than 30 years of discussion.
You can find extensive information on private company financial reporting on the AICPA's special web page. The site offers:
Our dedicated web page at aicpa.org/privateGAAP provides additional information and resources, including a video from AICPA President and CEO Barry Melancon, CPA, on the FAF proposal.
Now that the AICPA has announced the 10 semi-final teams for the 2011 AICPA Accounting Competition, you can tune in November 14 and help decide which semi-finalists make it to the finals. Ten very smart and creative accounting teams, made up of accounting undergrads from across the U.S., are competing in the competition, investigating a potential financial fraud case and are searching for clues that build skills for their future in accounting. Weigh in on which of the teams has presented the best video report and help them get noticed by the competition judges. First, second and third place awards will be announced on December 17.
This week the AICPA and the Society for Human Resource Management (SHRM) announced the nine winners of the inaugural year of the Workplace Leaders in Financial Education Award. This first-of-its-kind award recognizes organizations with exemplary workplace financial literacy efforts to enhance employee financial well-being. More than 300 applications from employers of all sizes located in 43 states were evaluated by CPAs, HR professionals and members of the President's Advisory Council for Financial Literacy. The winning companies stood out because their financial education programs showed results, innovation, effective tactics, and a significant scope in increasing employee financial wellness. This program builds on the success of the profession's award-winning 360 Degrees of Financial Literacy, the volunteer effort of the CPA profession to improve the financial well-being of all Americans. For a complete list of winners and more information about the awards program, visit wlife.org and read the press release.
Local business is affected by events outside U.S. borders and well-informed CPAs must stay up-to-date to provide their clients the best guidance. Staying up to date just got a little easier with the re-launch of the International Interest Area on AICPA.org. The updated interest area provides CPAs with compendiums of organized guides and links, including a growing National Fact Sheet library of nation-specific links to foreign governments, central banks, securities and professional regulators and a guide to Mutual Recognition Agreements. Students and aspiring CPAs will find up-to-date information about international administration of the U.S. CPA Exam and AICPA members can access compiled links to U.S. income treaties and an extensive list of international accounting communities. Read this blog post on AICPA Insights for more information.


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Enroll Now!
I enjoyed this course IMMENSELY! I found the instructor's writing style extremely easy to follow and full of ideas to use in my classroom! I would definitely recommend this course to my fellow teachers! GREAT Course!!!!
Great class jammed with useful ideas that I could implement in my classroom, almost immediately!!! Loved it.
I really enjoyed this class! It gave me tons of ideas for centers to implement in the classroom. I loved all the tips and hints on how to plan centers, set them up, introduce them to the class, etc. I would definitely recommend this class to others!
The instructor provided a wealth of information and resources. Thank you!
This was a great class!!!! I learned so much. I can't wait to implement the ideas I have learned from this class. I would recommend this to teachers especially first year teachers. Thank you for offering this great class.
I am very glad that I took this course. I believe the things that I learned will be especially helpful to me this school year because I have a large class with wide differences in abilities. This is a great course and I would recommend it to others who are interested in using centers and differentiation in instruction. The instructor was wonderful... very knowledgeable in her subject area and she uses humor very effectively!


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Tumbleweed's Tiny Gingerbread House Contest!
Hey Tumbleweed Lovers!
Our Facebook friend Christina Rodriguez had a fantastic idea for this holiday season: making a Tumbleweed gingerbread dream house. We liked it so much we're raising the stakes.
Are you ready to get your holiday tiny house cheer on?
Grab your kids! Grab your grandparents! Grab some tubes of frosting!
It's our first annual Tumbleweed Tiny Gingerbread House Contest!
Tumbleweed's own Wendy working on her gingerbread masterpiece
First place winner will get a copy of both the Small House book AND the DIY Book of Backyard Sheds and Tiny Houses. One runner-up will win a copy of either book, their choice. Both winners will have their gingerbread house photo featured on the website and our Facebook page.
Anything goes: creativity is key!
Contest Rules:
Please submit a high-resolution photo via the Contact page on our website with a short description. Make the subject line "Tumbleweed
Gingerbread House Contest." We'll
accept entries up until December 22
and make our decision by December 23- just in
time for the holidays!
Extra points if you draw up plans for your gingerbread tiny house. Extra extra points if you attach it to a tiny trailer.
Enjoy, and good luck!
I got so excited about this contest I built my own tiny gingerbread house this weekend.
Can you top this beauty?
Thank you to all those of who have submitted their Tiny Gingerrbread Houses so far! We have seen some amazing houses. We decided that we're going to let you, the fans pick the winner for this contest. We will post the top 3 Tiny Gingerbread Houses this Saturday, December 22nd on Facebook. You will have until 2 pm PST on Monday, December 24th to vote. The picture with the most "likes" will win. Good luck!!!


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make your own silhouette picture.
48 comments:
Oh my goodness Em', that turned out awesome! Can't wait to make some of my two soon.ReplyDelete
Ooohhh...LOVE this idea! Thanks for sharing :)ReplyDelete
O.M.G. I love that! I'm totally doing it!ReplyDelete
this is such a great idea! thanks for sharing!ReplyDelete
hey sweet girl! love this project :)ReplyDelete
PS. i always get excited when you have a new blog post up.
This is DARLING! You are so talented, I hope you know that! I am definitely going to tweet this...people need to see how easy this is!ReplyDelete
What a super cute family you are! Enjoyed looking through some of your posts...you got some mad photo skills!ReplyDelete
Very cute! You are so stinkin' creative! Thanks for sharing!ReplyDelete
we had ours done at Disney!
but this is so much better!
Awesome!! can't wait to do it!ReplyDelete
um, brilliant. i am doing this craft ASAP and then posting in on my blog as if i made up the idea all by myself. ha.ReplyDelete
um, absolutely brilliant, Midas of all things crafty. you are amazing. so let me tell you how much i love reading jami's hilarious comments on your blog, and then picturing you reading them and laughing. this makes me laugh, and i love it. keep em coming, jamie.ReplyDelete
You could also then scan your black picture... and then print out multiple copies (grandparents) - so you only have to do all of the fiddly cutting once!ReplyDelete
This is absolutely genius, and I can't believe I've never seen anyone do it before! I might even do it tonight. My printer doesn't do photos very well, but the beauty of this is that it doesn't matter! Oh, you have no clue how excited I am...ReplyDelete
Sounds so quick and easy! I've been dying to make my own for years. You've provided some great inspiration. Thanks!ReplyDelete
What a great project! Makes me wish I either had a girl with nice hair, or had done this when my son was a baby and had hair that stuck straight up!ReplyDelete
This is my first time visiting your blog (found it through ohdeedoh) and I love this so much! I already have the absolute perfect picture to use and it was just waiting for this project to come along. Thanks for the idea... and thanks to whoever suggested making copies for grandparents, brilliant!ReplyDelete
genie, that is a fabulous idea!!ReplyDelete
Hi Emily, I have just found your blog today, and I love the silhouette ideas. Will visit your blog regularly. I have just started my blog this year and so far blogging is funReplyDelete
The silhouette idea is fab. I like your site. It is minimalist and stylish!ReplyDelete
Love this!! Did you use a flat or satin black paint?ReplyDelete
I wanted to let you know that I featured this tutorial with a link to it and your main blog page on my new blog for my fledgling paper goods company:ReplyDelete
I love how simple you made it with the photos of each step! Great tutorial, so glad Odeedoh directed me to your blog! lovely photos!
i don't know how i stumbled across your blog but i am so grateful i did. i am looking forward to trying this little craft...i'll let you know how it goes. oh and this possibility song rocks.!ReplyDelete
That is AWESOME!!!! Thanks so much for sharing,i will try that.ReplyDelete
I finally got my silhouettes done! http://heathanddena.blogspot.com/2010/02/make-your-own-silhouette.htmlReplyDelete
Thanks for the great tutorial!
This comment has been removed by the author.ReplyDelete
This is such a great idea! So creative :)ReplyDelete
Got mine done! Thank you! http://www.southshorekidsblog.com/2010/02/silhouette-picture-craft.htmlReplyDelete
Wow. That is so awesome... I never thought it would be so easy. I will definitely try this out! :)ReplyDelete
I am not a crafty person by nature but I do oh so love pretty crafty things so I am working on it. I did this project and it turned out wonderful! Thanks so much for sharing such an easy way to do this! Love it!ReplyDelete
P.S. Just found your blog from TVP and really enjoy it! You're great! Best of luck with getting your newest addition home soon!
i've been swooning over these on etsy for the longest time. just finished making them using your method and it was super easy. thanks so much, emily! you rock!ReplyDelete
I've been drooling over all of the silhouettes as well but they're so pricey! Yours turned out fantastically! When our next arrives I'll definitely be doing this to go above our mantel!ReplyDelete
Very creative!! I love it and might attempt this over the weekend :)ReplyDelete
this is SOO awesome! must do this once my baby is born!ReplyDelete
I've been making these for years, and my favorite thing to do is to make them on the first of every year, (or once a year, whatever you choose) and then put up the new ones every year, save the old for when my kids get bigger I can give some to them but I will still be able to keep some for my selfish self :) win/win! Love yours!!ReplyDelete
This looks so easy!!! I am going to do this soon. Better than paying to have it done!ReplyDelete
Lovely, Never thought it could be so easy!ReplyDelete
Thanks for sharing.
Easy and so beautiful! Love it :)ReplyDelete
LOVE LOVE LOVE this!!! I've been wanting to have this done, but now I'm definitely going to do it myself! Wahoo! :)ReplyDelete
Just made my own and it is so stinkin' cute, I know it'll be the hit of the holidays! Thank you SO much!ReplyDelete
cute! love it so much!ReplyDelete
Such a simplified way to go about making sihouttes!!! Thank you so much…I'm planning to make large canvas versions as artwork for our basement playroom. I'll be sure to link back to this tutorial when I blog about the room.ReplyDelete
Have a great weekend!
Oh my!!!! FINALLY somebody figures out a way to get the job done without 1.spending a zillion years working on it and 2.a computer program which I cannot operate! I can finally attain my precious 4's silhouettes! I just found you from over at Jones Design Company, and I'm so glad I hopped over! You have a beautiful family! You and I are kindred spirits. My family makes fun of me for taking pics of pretty much EVERYTHING in our lives...I know one day they will thank me, and yours will of course thank you:D It also beings me so much joy to see another mother raising her young family with Christ at the center. You. Are. Awesome.ReplyDelete
This is awesome! I'll be doing my own version for Pintober!ReplyDelete
This is awesome! I will be doing my own version in a video on youtube!ReplyDelete
What a fun project!! I shared on my blog, in a handmade for the holidays list. Feel free to stop by and say hi!! http://theprettypickle.com/blog/handmade-for-the-holidaysReplyDelete
I love this!! What a great idea! I'm putting together a round up of DIY crafts on my blog and wondered if you'd be willing to let me use a picture with your link. Thanks!!ReplyDelete


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USU announces Nike executive will speak at commencement
By Kevin Opsahl | Posted: Tuesday, April 2, 2013 12:45 am
The man in charge of all branding for Nike Inc. will be the commencement speaker for Utah State University's 126th graduation ceremony, the university announced Tuesday.
Charlie Denson, a 1978 USU alumnus, will speak May 4 at the Dee Glen Smith Spectrum in Logan, where he will also receive an honorary degree.
"We are honored that Charlie Denson, a USU alum, has accepted our invitation to address our graduating students this year," said USU President Stan Albrecht said in a prepared statement issued Monday. "Commencement is a time for celebration and inspiration. His message will resonate with our students and inspire them at this turning point in their lives."
To read the rest of this Herald Journal story about Charlie Denson click here.


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awkward guy, pretty chill, defenitly aint no damn snitch, this mothas hard
ay i heard the cops got him, dont worry its strait hes milad
door anonlikeme 12 augustus 2012
Trending Now
Can you define these popular missing words?
Top Definition
The coolest person of all time.
Girl 1: Milad is sooo cool!
Girl 2: I want him to blow his load on my face!
Girl 1: Me first!
Girl 2: I want him to blow his load on my face!
Girl 1: Me first!
door Bailey the Blind Watchdog 10 november 2004
Milad means tight he isnt a wangsta fo sho he is a real gangsta n who eva thinks athawise can see me
person1: milad is so cool
person2:hell ya
person2:hell ya
door allaa 27 april 2005
the action of sleeping with everything that walks OR breathes. can also be used as a noun for someone who sleeps with anything that walks or breathes.
he just pulled a milad by sleeping with that fugly girl.
door pouijoerg 16 december 2005
a gay kid who thinks he got swag but really don't
Person 1 : hey did you see that milad kid yesterday?
Person 2 : dude no way!! did you see his fake nikes??? WOW WHAT SWAG!
Person 2 : dude no way!! did you see his fake nikes??? WOW WHAT SWAG!
door thedefinitionator 16 september 2014
A wankster who tries to change his absolute appearance to be "cool". Usually found after the outburst of G-Unit. The milad is usually found with his slutty girlfriend, Who has a Cabbage Patch Snatch. He will be pumping your gas in a few years so remember the name.
That wankster is such a Milad.
door Alex 15 april 2005


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Systemwide Events Calendar
|Thursday, May 2
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Career Matchmaking OPEN HOUSE
Windward Campus, Kuhina 106
|Mathematics Final Oral
Manoa Campus, Keller 301
|Business Night 2013
Sheraton Waikiki, 2255 Kalakaua Ave, Honolulu, HI 96815
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- Lineage : A Family Tree of Printmakers
- Arts Exhibition: Ainu Treasures: A Living Tradition in Northern Japan
- Revit Architecture 2013 Essentials
- Shift: Bachelor of Fine Arts Exhibition 2013
- Introduction to Bentley MicroStation (Using MicroStation PowerDraft)
- Course Reserves Deadlines and Information
- ECE Club Meeting


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Nitrogen-Filled Tires & Better Gas Mileage?
|Email Print
When I bought my tires from Costco, I noticed the caps for the valve stems were a flourescent green and asked about them – it means the tires are filled with Nitrogen. After reading a friend's blog claiming that nitrogen-filled tires get 0.5 mi/gal better gas mileage and have a longer tire lifespan, I wanted to find some "proof" to these claims. The belief, also pushed by Costco in their tire brochures, is that the larger nitrogen molecules don't react to temperature changes (better tread life and mileage) and lack moisture (won't corrode the tire from the inside). It doesn't affect my decision if these claims can't be proven because there is a miniscule increased cost for using nitrogen (I can only "fill" my tires at a Costco, most gas stations only have air, but the service is free).
The theory is that the oxygen in the air inside the tire, when heated as a result of driving, can oxidize and rot the inside of the tire over time. A nitrogen filled tire won't oxidize for obvious reasons, no oxygen. This is all anecdotal though and for most people, I think the tread of the tire wears out before the tire does from internal rot.
As for the nitrogen not reacting to temperature as much as compressed air, it's probably a bit of snake oil magic going on there. At such low pressures, the nitrogen behaves like an ideal gas (just as oxygen and water vapor) so that means pure nitrogen will act just like regular air. A 0.5 mi/gal improvement in gas mileage is 1.6% improvement (on my car, which gets a little more than 30 mpg) which seems way too much.
It sounds like the "nitrogen is better than air" theory is not entirely true but since it costs me very little (if at all really) I won't be complaining much about it. As long as you don't pay for nitrogen, fill it with nitrogen; but if it costs you money, ask for regular air.{ 167 comments, please add your thoughts now! }


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An eye for nature
Local artist shares passion for feathered friends, barns
April 13, 2013
A local photographer's passion for feathered friends and freshly cut hay has turned into an eye-catching display....
Great article. BTW, the phone # at the bottom should have been 4239 and the picture on the web of the prison cell is not Debbie's. Kirk
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Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
NSCLC is "Major Battlefield" as Merck,...
In small molecule drug development, it is often said that the low-hanging fruit has already been harvested. Most structures that are chemically accessible, manufacturable, and druggable have already been considered.
Somewhat analogously, the leading edge in biologics development are proteins that for one reason or other present development or manufacturing challenges. Reasons vary, from difficult transfection or poor expression, to low yields or high losses on purification.
Among the speakers at CHI's recent "PEGS" conference was Anne London, Ph.D., investigator II and lab head at the Novartis Institutes for BioMedical Research, who spoke on evaluating and streamlining platform approaches to preclinical protein production.
Preclinical protein production is a broad discipline, with expectations and goals differing from project to project. Rapid, efficient production are common goals, but challenges arise with differing maturity of programs (e.g., initial antigen production to late-stage in vivo material) and quality specifications. Dr. London presented case studies reflecting her group's approach to arriving at a platform capable of adapting to fit production requests, with emphasis on cell-line evaluation and impurity clearance.
"The goals for each production vary based on the protein's intended use," she said. Live rabbit studies require a large amount of "clean" protein with very low endotoxin levels. By contrast, endotoxins will not affect proteins used in affinity binding assays, where buffer choice and concentration may be more relevant. "Fully understanding the product's intended use is critical to guide production to the defined endpoint."
Preclinical production platforms are "much simpler" than a GMP biologics manufacturing platform because they entail fewer polishing steps and less validation. For example, viral clearance is not required at the preclinical stage, so virus removal and inactivation are not explored. "With the goal of simply making enough protein for the intended use, only steps needed to grow, capture, purify, and deliver the protein are considered at the preclinical stage," Dr. London explained.
A recurring production theme is low endotoxin material. In one case with the production of a His-tagged protein, endotoxin levels were too high (>1.0 EU/mg) for the intended use after standard purification.
"Guaranteeing product quality below 1.0 EU/mg is difficult, if next to impossible, in a non-GMP setting." The situation resulted in the evaluation of multiple endotoxin-removing membranes and filters, with the final solution being a detergent extraction. Dr. London reports spending "many hours" troubleshooting this process, but eventually the product met quality specifications.
Project scaleup is another issue facing early-stage protein production. Dr. London's group encountered an antibody that was evaluated at small scale in multiple transient cell lines before scaling into a Wave bioreactor.
"After picking the highest expressing cell line at the small scale, the culture was scaled up in the Wave with poor results; the expression levels in the flask did not scale linearly into the Wave." This production required further process development at Wave reactor scale to meet the expression levels seen in shake flasks. "Not every project will scale up well, so time must be budgeted to allow for cell culture process development in these rare cases," Dr. London warned.
Haruki Hasegawa, Ph.D., senior scientist at Amgen, presented an investigation on the role of secretory cargo in shaping maximum protein secretory capacity. He began by questioning the nature of a cell's maximum secretory capacity: Is it simply due to the collective contributions of intrinsic cellular machinery?
Dr. Hasegawa studied an unusual CHO phenotype that, under optimized growth conditions, produced a model human IgG clone as rod-shaped crystals within the endoplasmic reticulum (ER) lumen. Crystal growth was accompanied by cell enlargement and multinucleation, and continued until crystals outgrew cell size and breached the cell membrane.
In this phenotype the efficiency of IgG protein synthesis and oxidative folding exceeded the capacity of ER export machinery. As a result, export-ready IgG accumulated in the ER lumen until a threshold concentration was reached to nucleate crystals. "Using an in vivo system that reports accumulation of correctly folded IgG, we showed that the ER-to-Golgi transport steps became rate-limiting in cells with high secretory activity," Dr. Hasegawa said.
Do techniques exist for altering physicochemical properties of secretory cargo generally, for expression systems other than this phenotype? "There are two major ways to alter the physicochemical properties of secretory proteins," Dr. Hasegawa explained. The first is to alter post-translational modifications, the second is changing the protein's primary sequence through mutagenesis. "These two approaches are widely employed by protein engineers using various model organisms and any type of protein."
Commenting on this work on the Faculty of 1000 website, Dr. Jesse Hay at the University of Montana wrote, "What this story tells us is that a CHO cell's secretory capacity is not inherently limited by its ability to synthesize, oxidatively fold, and assemble functional product—it is limited by its ER export machinery."
Morten Nørholm, Ph.D., senior scientist at the Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark, presented a talk on improved expression of a poorly expressed membrane protein by fusing its gene with that of an N-terminal peptide.
Dr. Nørholm could mimic this effect by re-engineering the 5´ end of the membrane protein with "favorable synonymous mutations." This effect is surprisingly large compared to substitutions at other locations within the gene.
Gene fusion was conducted in high-throughput fashion using a versatile molecular cloning technology, "uracil-excision". This PCR-based cloning technology was invented 20 years ago but has been neglected due to incompatibilities with modern PCR techniques.
In 2006, Dr. Nørholm's group published a paper in Nucleic Acids Research identifying a compatible proof-reading DNA polymerase. "Today the technology is heavily used, open-source, simple, and inexpensive," Dr. Nørholm explained. "We hypothesize that the peptide simply replaces a suboptimal 5´-end and/or N-terminal peptide sequence of the native construct. It is not rocket science, but a very simple and useful tool indeed."
How generally applicable is this approach to nonmembrane proteins? "We work almost exclusively with membrane proteins, so it is hard for me to say. But the effect was similar for the few soluble proteins we tested," Dr. Nørholm explained. "The expressing organisms—bacteria—may be part of the magic due to the strict architectural constraints of the ribosome binding site in relation to the 5´ end of the coding sequence." However, as Dr. Nørholm pointed out, there have been reports describing optimized species-independent translational leaders for cell-free expression.
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UNIVERSITY PARK - Backup quarterback Paul Jones said he briefly considered transferring when the NCAA sanctions came down, and now that he's staying, he will "definitely see time this year" on the field, according to coach Bill O'Brien.
"Maybe for the first, like, hour when they said we could go anywhere," Jones said of his transfer thoughts. "I started daydreaming, picturing myself in different uniforms and playing for other teams.
"But when it came down to it, the bond I have with my teammates here outweighed everything, and I knew I wanted to stay here."
Article Video
Senior Matt McGloin was anointed Penn State's starting quarterback in June, but O'Brien does plan to give the redshirt sophomore Jones opportunities to play. The coach gave no specifics about how Jones would be used.
"Paul will play this year. Paul will play," O'Brien said. "Paul is a good player, an instinctive guy, a playmaker. He's progressed."
Jones, who sat out last year because of academic issues, said he and McGloin "have different styles."
"I'm a little bigger and a little faster ... but at the same time there's a lot of things that are similar," he added.
Jones said his parents and his high school coach heard from about 20 schools looking to recruit him. Nine PSU players did transfer, including third-string quarterback Rob Bolden, who was beaten out by Jones.
"We don't have any hard feelings towards anybody that left," Jones said.
Hairy issue: McGloin sported a full beard during media day, something that wouldn't have been allowed under Joe Paterno. O'Brien, though, has a much looser hair policy, and several players are taking advantage of it.
Third-string quarterback Shane McGregor, whose nickname is "Sunshine," has let his blond hair grow out, something he was never able to do before.
"Oh no, that's for sure," he said with a laugh. "You see me, you see some of the guys around here, that would never be happening."
Linebacker Gerald Hodges said the facial hair on some of the guys makes them look "nasty," but he meant it in a good way as he was referring to how fierce they look.
Linebacker Michael Mauti and running back Michael Zordich were having a discussion about which one of them has the best hair on the team. Neither of them, however, have locks as distinctive as McGregor or receiver Alex Kenney, who has a big, wavy head of hair.
Then there's McGloin's beard, which he said, "might be here to stay, at least for the first game."
"It just allows us to have more fun," McGloin said of the hair freedom. "A lot of guys are trying to grow mustaches all through camp. It's just another way to have fun, kind of take your mind off the playbook and practice as well."
Three tight ends?: It's no secret that O'Brien will utilize the tight ends more - there are two starters in the basic offensive package - but the Lions have formations with three and on occasion even four tight ends on the field at the same time.
It may not be unusual, then, to see at least three tight ends take field for some plays this season.
"It's nuts, but it's great," starter Kyle Carter said. "I love it. I'm excited."
Kicking jobs: With Anthony Fera gone to Texas, O'Brien said sophomore Sam Ficken is in line to take over the place-kicking duties. The punting job is a close battle between junior Alex Butterworth and redshirt freshman Matt Marcincin from Blair Academy in Malvern.
Road awareness: It's been suggested by some that Penn State could face extra hostility from fans on the road in light of the scandal and NCAA sanctions.
"I don't really get into that too much," O'Brien said when asked about that possibility. "I talk about focus. We have crowd noise and blast music and things to use our silent cadence.
"If you've got rabbit ears on the road, you're in the wrong line of work. It's time to play football, and you have to focus on the game and the task at hand, not the crowd around you."
Royer update: O'Brien would not disclose the circumstances that led to redshirt sophomore tight end Dakota Royer leaving the football team. Royer announced his decision Wednesday but will remain in school, and as part of the NCAA ruling, he can remain on scholarship for his education even though he's no longer on the team.
"You'd have to ask him about circumstances," O'Brien said. "You'd have to ask him. I respect Dakota, think he's a great kid. He's just decided not to play football anymore. I'll keep the conversation between him and me."
Uniform changes: The Lions' uniforms will features players' names on the back this season, plus a blue ribbon to show support for victims of child abuse.
"They both mean a lot," Jones said when asked which change is most important. "Coach O'Brien said the last name is so everybody can know who the guys [are] who stuck with it."
As for the blue ribbon, Jones added, "It's important ... to make sure that everybody knows that we didn't just forget about what happened."


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Sanrio Hello Kitty Stamp Seal Signet 1PC Frog. Your little princess and her friends enjoy many hours of delightful creative play with this exciting stamp. Everyone joins in on the fun adding decorative touches to favorite accessories or letters to friends or personalizing greeting cards and artwork! NON-TOXIC. CONFORMS TO ASTM D4236. Recommended for Ages 5 and up Features:●Brand New Item●Sanrio Licensed product. The listing is for 1 PC ONLY. ●Dimensions: 2.3" x 1" x 1" / 6 x 2.6 x 2.6 cm●Material: Plastic●Practical & Cute item
- Price: $7.79 - In stock
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on May 19, 2013 - 12:24 AM
The stronger Doug Whaley turns out to be as a leader, the better for the Buffalo Bills.
Will Whaley prove to be a forceful, "full-service" general manager? We don't know. You never know what you're getting when a man steps into the GM post for the first time.
But the more Whaley asserts himself — even though we don't know about his ability to push the right buttons — the better the Bills' football results stand to get.
Why? Whaley's resume is as good as you're going to get for a first-time general manager. He's now the man with the best eye for talent in the organization. His resume and title say that's the case. In reality, sometimes that might mean he's judging which of his scouts is sending the best evaluation across his desk. So be it. He needs to parlay his judgment into getting what he wants.
It's encouraging that he brought in two of his own top lieutenants right away. The Bills hired Jim Monos from New Orleans and another Pittsburgh guy, Kelvin Fisher, from the Steelers. Monos, formerly Southeastern scout for the Saints, becomes the new right-hand man. The Saints picked five Pro Bowlers in the third round or later over that span; no other team has more than two. Fisher, a scout in the West for the Steelers, becomes the new overseer of college scouting.
A skeptic might wonder: Does this give the Bills three guys new to their positions, all of whom are in over their heads? We'll see. But the hirings are an example of Whaley putting his stamp on the football department. He wanted his guys in place.
Good GMs have to get their start somewhere. Baltimore's Ozzie Newsome, the New York Giants' Jerry Reese and Atlanta's Thomas Dimitroff all were unproven young GMs at one time. Now they're three of the five or six best in the business.
Talent evaluation is the most important part of the job. Whaley needs to keep talent coming through the pipeline of the draft, especially in Buffalo, where it's harder (no matter what anybody says) to woo free agents than it is in Miami.
However, the best general managers are more than just glorified scouts. The general manager also needs to have a forceful personality. The GM is operating in a world of forceful personalities, both inside and outside the organization. Administrators, coaches and scouts in the NFL all tend to be passionate and convinced their judgment is correct. Job security is tenuous in the NFL. Those realities breed a "protect-my-turf" mentality. All of that works against a cohesive, smooth-running football department.
It's up to both team president Russ Brandon and Whaley to breed organizational trust. The coaches aren't complaining: "We're teaching them but the scouts aren't getting us the right guys." The scouts aren't complaining, "We're finding talent but the coaches don't know what to do with it." Communication among a player, his agent, his coach and the general manager flows freely. People aren't talking behind each others' backs.
A lot of that is eliminated if the general manager is setting a commanding tone. The Bills' organization was in lock-step with Bill Polian when he was running it, and that was a good thing. It wasn't just because he ruled with an iron fist. Tom Donahoe ruled with an iron fist in Buffalo, too, but the team didn't have organizational trust.
At least when it came to his football staff — his coaches and scouts — Polian was listening to and empowering his people enough that a good consensus was reached over and over. (It helped Polian that his personality was balanced by Marv Levy in Buffalo and Tony Dungy in Indianapolis, both of whom enhanced organizational trust.)
So a good GM is a great communicator within the organization. A good GM has relationships with agents to enhance the credibility of the organization. A good GM also has a good handle on the salary cap and the true market value of players.
This is an area where Whaley potentially could be an improvement over Buddy Nix. Nix was more involved in the cap and negotiations than Levy, who took a Sgt. Schultz approach to that sphere. But the perception here is Nix wasn't as influential in those areas as Dimitroff, Newsome and Reese. Not that Whaley should be lording over Jim Overdorf, the chief cap analyst and negotiator. But he has to be an important part of the decision-making, and he must have a good handle on planning three and four years down the road.
Whaley seemed very comfortable letting Nix be the front man and in letting Nix deliver the organization's message to the fans. Nix was good at it. Is it a sign Whaley is too low-key? Ex-Bills executive Tom Modrak said he never saw Whaley back down from a tough spot. Hopefully that holds true. It would be good if Whaley communicated clearly and well in public, because that's part of setting the tone inside the organization.
Nix set a good tone within the organization. People trusted him, from the players to the owner. The Bills spent money, in part, because there was faith that Nix's evaluations were on the mark. To that end, Whaley is starting out on good footing with Brandon.
Make no mistake, Brandon holds the ultimate power in the Bills' organization. He's the president. He's a forceful personality. Brandon says he takes pride in delegating power to his top lieutenants. There's plenty of evidence that happens in regard to other Bills executives.
It's in Brandon's interest to see Whaley succeed. Brandon executed the transition of power from Nix to Whaley. Whaley is going to have to be very good at selling his views to Brandon, especially when times get tough. In that regard, his job is similar to that of his predecessors in the GM seat. They dealt with Ralph Wilson, who was hands-on. So is Brandon.
Is Whaley up to all that? Is he the total package as a leader?
We're going to find out.
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A photo, taken with your celphone, of your own junk. Like a selfie, but far more special.
Also known as a dick pic
Instead of sending it to Jeannie, I accidentally sent my junkie to my Grandma.
от The AndyChrist 04 декември 2013
Joined. Under. Necessity to. Kill. Internal. Ego
A Mary Magdalan Fan!!!
A Mary Magdalan Fan!!!
Much J.U.N.K.I.E. Love to my Mafia family!
от Mizz Maggot 20 май 2008
A person who asks for their next fix anywhere. I mean over the internet on the streets fuck they are so desperate they'll even ask their imaginary friend.
Junkie- hey got any heroin
Me- fuck no
Junkie- hey got any heroin
Me- NO DAMMIT GET OFF MY LAWN
Junkie- hey got any ............
Me- fuck no
Junkie- hey got any heroin
Me- NO DAMMIT GET OFF MY LAWN
Junkie- hey got any ............
от Stephen Bier Jr 09 май 2010
Often referred to as a crackhead, or a bum on the street. Slang word highly used in the ATL.
"That junkie over there just asked me for spare change!"
от A-Town Boi 11 юли 2009
A junkie is someone that injects their drug of choice by a needle. Dirty or clean needles. They shoot up in their arms, under their fingernails, in their foot, in their neck, basically anywhere they can find a vein. A junkie is an addict who can't get high any other way than to shoot it.
A junkie is a person with scars on their arms,known as track marks.A junkie is Someone who will do whatever it takes lie, steal, cheat, do sexual favors, belittle themselves if thats possible for that next fix.A junkie might have bruises and knots from missing their vein.
от flippyfemale 02 ноември 2007
"Did you see that jacket he was wearing? What a junkie."
"Don't talk to her."
"She's too much of a junkie!"
"Don't talk to her."
"She's too much of a junkie!"
от pootart 19 май 2009
A Glaswegian Who Sits And Gets Money From The Council To Sit And Inject Themselves!
An Easterhouse Punter!
от A.J 20 май 2003


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Whether you've got a large garden or only space for pots, you can still grow strawberries! Many of our varieties can be grown in containers or Stackapots and Flower Pouches™ and are well-suited to hanging baskets and Patio Planters. Read our 'How to grow strawberries' guide for more information on the best types of strawberry for you.
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Strawberry 'Mount Everest' (Everbearer/ All Season)
Fragaria x ananassa
A unique climbing strawberry! This fast, strong growing variety will produce runners up to 1m (39") in length that make a real talking point when trained up a trellis or obelisk climbing frame, or cascading from window boxes and hanging baskets. Better still, Strawberry 'Mount Everest' is an ever-bearering variety that produces a delicious crop of medium sized, sweet, juicy fruits from June right through to September! Height: 1m (39"). Spread: 30cm (12").
Estimated time to cropping once planted: 4-8 months.
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Culinary note: Some parts of these flowers are edible. For more details about edible flowers click here.More info
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The Dillingham Ticket Office is open noon-5pm, M-Th and noon-4pm on Friday. Please call 607-274-3224.
THROUGH OCTOBER 1st ONLY! Ithaca College Theatre Offers Ticket Packages for Its 2016-17 Season!
Ithaca College Theatre offers great savings through a variety of season subscription packages. In addition to discounted ticket prices, subscribers have the benefits of guaranteed seats for each of the six main-stage shows, the ability to pick their desired dates, and complimentary ticket exchanges throughout the season.
Ithaca College Theatre will kick off the 2016-2017 season with one of Federico Garcia Lorca's best-known tragedies, "Blood Wedding": a tale of deception, yearning, and vengeance. Full of song and chant, this poetic play is an exploration of the tension between individual desires and societal expectations in 20th-century Spain.
The fall musical will be "Company" by Stephen Sondheim and George Furth. It's Robert's 35th birthday and he's still single, much to the dismay of his supportive, married friends. This Tony award–winning musical marries an exciting score with an in-depth look at the complicated choices people face.
The season of the winter solstice inspires IC faculty choreographers to put bodies in motion as the world turns toward long nights and inner light. The December dance concert, "Winter Bodies," will be choreographed by Lindsay Gilmour, Amy Walker O'Brien, and Courtney Young.
Mozart created "La Clemenza di Tito" when commissioned to write an opera to celebrate the 1791 coronation of the Holy Roman emperor Leopold II. This opera seria will be offered in February/March and features a magnificent score portraying a generous ruler caught in a web of jealousy and revenge.
The spring musical, Mark Blitzstein's "The Cradle Will Rock," premiered in 1937 amid controversy. Society continues to play and replay its story today: the clash between the business mogul and those seeking equitable treatment for workers.
Playwright Aphra Behn, the first Englishwoman to make her living as a professional writer, uses "The Rover" to reveal the hopes and hypocrisies of love, sex, and marriage. Though written in 1677, IC Theatre's production of "The Rover" will be set during Mardi Gras in modern New Orleans. Masquerades, mishaps, and love triangles abound when lustful men woo cunning women.
Ithaca College Theatre student/youth subscription packages start at $30 and include all six shows of the season. Regular admission packages start at $42, and discount packages for senior citizens, alumni, Ithaca College faculty and staff, and Friends of Ithaca College start at $36.
Single tickets for all performances are currently on sale. Purchase tickets at Ithaca.ticketforce.com.
Stay up to date with IC Theatre! Please "like" us on Facebook, follow us on Twitter and join our e. newsletter mailing list by going to firstname.lastname@example.com.
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Other projects/programs
The Trust for Public Land is using a $10 million grant from the Helen Diller Family Foundation to completely re-design two existing playgrounds at Civic Center Plaza that are heavily used by children in surrounding neighborhoods where parks and open space are limited.
The community is working with the City of Richmond and The Trust for Public Land to revitalize John F. Kennedy Park as a safe and vibrant gathering place.
Residents of San Francisco's Western Addition neighborhood are rallying to reclaim and rejuvenate Buchanan Mall with creative elements that honor the rich history of the neighborhood and provide inspiration for a brighter future for Buchanan Mall.
Rocky Graham Park is the only outdoor recreational space in Marin City, the most diverse city in the county. The Trust for Public Land worked with the community to re-design the park, which re-opened in July 2015 with modern amenities.
For years, locals have asked for the Red Car property in Silver Lake-Elysian Valley to be converted into a real park, an invaluable resource in a crowded area of the city where green space is scarce.
For decades, this vibrant San Francisco park was celebrated for its spectacular views of the bay, its eye-catching, 70-foot-high steel sundial, and the city's first skatepark.
The Trust for Public Land is working with City of El Cerrito to purchase the Madera Hillside property and unite the Hillside Natural Area forever.
The people of Ventura's Westside neighborhood needed a park. But with little open space and a very limited budget, they waited years for the right opportunity.
El Sereno in East Los Angeles has one of the greatest concentrations of children under five in the county—but not nearly enough parks or playgrounds to serve them.
We're working to build a new park on Madison Avenue in East Hollywood. If funding is secured, part of this half-acre lot will be transformed into recreation play spaces and the remainder will become a community garden.


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The Palliative Medicine and Supportive Care Program
The issues surrounding an acute or complex illness can be difficult to manage.
Palliative Medicine helps you manage the physical, emotional and spiritual challenges of a serious illness. We tailor our services to your needs and provide support to loved ones who have a critical role in your health and well-being -- at any stage of illness.
What is Palliative Medicine?
Palliative Medicine is about improving quality of life, providing an extra layer of support, and having a team focus on patient care when you are facing a serious illness.
Palliative Medicine aims to improve your quality of life by relieving the symptoms associated with serious illness. It can begin at any stage of a life-altering illness to help you:
Palliative Medicine can help shift the medical approach from crisis intervention to crisis prevention; for example, good symptom management may help avoid an unwanted hospitalization.
Palliative Medicine also aims to provide support for you and your loved ones as you face the uncertainty that comes with serious illness. Whether it's questions about your treatment choices or advance care planning, we partner with you and your family to navigate your care.
Palliative care is appropriate for anyone and their loved ones facing serious illness, including:
Meet Our Team
Who Provides Palliative Medicine Care?
Palliative Medicine offers an interdisciplinary, team-based approach to alleviate physical, emotional and spiritual suffering for both patients and their loved ones at any stage of their disease. Our team includes:
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How have your personal, academic and professional experiences led you to pursue the MSF degree at this time? Please discuss both your short- and long-term career goals, including your vision of your post-graduation employment, and describe how the Texas MSF will help you meet those goals.
Complete one or both of these only if you feel your application does not give the admissions committee a complete and accurate picture of your qualifications.
If your standardized test scores are low or if you have not had coursework that demonstrates quantitative and analytic proficiency, please tell us how you plan to prepare yourself for the quantitative rigor of the MSF curriculum.
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photo 1 of 109
Gegard Mousasi
TRAINING: I'm training every morning and every night – it's a lot of MMA and complete training.
When and why did you start training for fighting? I began training in judo at 8 years old. I turned pro in MMA 2003.
What ranks and titles have you held? Dream middleweight and light heavyweight champion and former Strikeforce light heavyweight champion.
Do you have any heroes? No
Did you go to college and if so what degree did you earn? No
What was your job before you started fighting? Security
Specific accomplishments in pro competition? Dream middleweight Grand Prix champion
Favorite grappling technique: Triangle choke
Favorite striking technique: Right overhand
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Player Programs
See how the players, staff, and wives utilize their time for the benefit of others.
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The Red Sox Foundation is committed to using the power of Red Sox Nation to create new and strengthened community partnerships. More »
Find out how we can help to support your New England charitable organization.
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Check out these community-related videos of Sox players and activities.
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Look inside The Red Sox Community Relations Newsletter.
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A shortage of volunteers means thousands of kids are currently on waiting lists for mentors across Massachusetts.
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Introduction to Arduino
Arduino is an open-source electronics prototyping platform based on flexible, easy-to-use hardware and software. It's intended for artists, designers, hobbyists, and anyone interested in creating interactive objects or environments.
With an Arduino you can control LED lights, direct the motors in a robot, trigger sounds, make any object a game controller--the possibilities are endless.
This three-part workshop gets you up and running with Arduino. No programming knowledge required. Everything you need for this workshop is provided, but feel free to bring your own Arduino and/or laptop.
Participants work in pairs, so bring a friend or be ready to make a new one.
Please register for all three sessions. Completed grade 7 and up*
* under grade 7 OK, with an adult. This workshop made possible by our friends at BloomingLabs.
Chris Hosler
- Location:
Program Room 2B
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Featuring hazelnut (cobnut), almond and walnut trees, our range of quality nut trees make attractive additions to the garden, giving colour in winter months and heavy crops of nuts from late summer/early autumn.
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Almond 'Robijn'
Prunus dulcis, Prunus amygdalus, Almond Oil Plant, Sweet Almond
Estimated time to cropping once planted: 2 years.
Useful links:Fruit rootstock guide More info
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Shadow Catcher
Active within 1277 Days
Hi! My name is Shadow Catcher
I am a Korat from Cedar Park, TX
Nicknames: Goofball, Fuzz, Fuzzer, Fuzzball, Furball, Fussbucket, Stinker
Age: 10 years old
Gender: M
Coat: short haired
Education: Look mom! I got the spider!
My favorite tricks and treats are: Tricks? Trriiicckkssss. .. I'm awesome, does that count? and Catnip papers are the best! 'Specially if you crumple it into a ball so I can hit it around on the kitchen floor.
Where I hang out: Top of the bookshelf, Baby! Woo!
My favorite grubs: If it's mine, it's mine. If it's yours, it's mine. It's all mine.
My pet peeves: Baths! I mean, really, what are you thinking?
What I love about my owners: She makes the best pillow! And I guess she's pretty cool too, you know, for a human.
My cat hobbies: Sleep. Is there anything else? Also, stalking mom around the house, that's pretty fun too.
Pet motto: You better be paying attention to me, even if I don't want you to be paying attention to me.
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My dog passed and my mom was asking if I wanted to get another (we've always had animals around and NOT having one was pretty much unthinkable). I asked (half-joking, because my mom has hated cats for years) if we could get a cat. She said maybe. I freaked out with excitement. When she pointed out that she had only said MAYBE, I informed her that it had taken 15 years for her to say something other than a flat out (rather impolite, if you know what I mean) no, and that I was going to be excited, thank you. Less than a week later (probably because of the sheer joy brought on by that simple MAYBE, ...and possibly the fact that I immediately started looking up cat breeds) I was given a list of requirements and a go-ahead. I settled on a Russian Blue as my top pick. Around two months later, while getting cat supplies at Petsmart we came across the weekly rescue animal visit. And I saw the most amazing little kitten ever. And he even had a Blue coat! It was a sign! Needless to say, we got him. He's been my irritant/ baby /best-friend/ cuddle-buddy/ alarm-clock/ heat-blanket/ photo-model ever since.
I've had 1070 friends visit me.
I'm the 54,423rd member on CatChannel.com.
3 friends have voted for me since I joined Club Cat!
Come visit me, Jozie Behr II, Penny & Sweetie.
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Vocal Juries and Midterms
Vocal Juries and Midterms
All vocal performance majors and minors are required to perform a vocal jury at the end of each semester for which they are registered for required private lessons. Juried singers prepare three pieces based on the required repertoire list. Each singer will choose his or her first piece, and the voice faculty will choose a second and/or third piece. The voice faculty then gives written feedback and a grade for each selection based on the criteria below.
Jury Grading Criteria
Any voice student can participate in the vocal midterm performance day, which usually falls about one month prior to juries. Voice majors and minors are required to attend midterms during any semester they are registered for required credit. The midterm at Westminster is designed to give students the opportunity to perform their jury pieces from memory in front of their colleagues and to get constructive feedback on their work from the voice faculty before the graded jury performance. Students who perform on midterm day will offer a list of three pieces they have prepared, and the voice faculty will choose one of the songs from that list. Following each student's performance, the voice faculty will give immediate, verbal feedback on the performance, both positive and constructive, on things the singer did well and what he or she can improve upon during the final month of the semester.
2013-14 Jury and Midterm Schedule
Fall Semester 2013
Spring Semester 2014


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I don't know how old the company is but I think I remember that the letter "I" was often changed over to "J" (or vice versa) in the Victorian times and earlier. Or am I dreaming again. :roll:
Dansk is the company name, Quistgaard (two 'a's, my mistake) was a designer there. Or possibly artistic director, as he does seem to have his stamp on an awful lot of Dansk designs. Anyway, as far as I can tell, his tenure ran from possibly the late 50s until the 70s. But that's just guesswork from the styles of the pieces I've seen.After a quick Google, there are some indications that he owned Dansk.
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June 2011 Developer Dinner Part 2: Building Cloud-based Apps with Windows Azure
- Posted: Aug 16, 2011 at 6:14AM
Right click "Save as…"
Part 2 of 2: Ready to get started building cloud-based apps, but not sure how to get started? David Makogonwill demonstrate how to jump into Azure quickly. He'll also talk about what you can do with the Windows Azure platform today, including non-.NET technologies such as C++ and Java, as well as 3rd-party applications.
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Top Definition
You suffer from padd when you open your phone to text someone and find yourself watching a video or playing a game. Forgetting simple tasks between flipping through screens. Phone attention deficit disorder.
Wow I was suffering from a bad case of padd. I opened my phone and forgot what I was looking up.
po Shovexxx Фабруар 12, 2015
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Usually "PADD designation," it stands for "person authorized to direct disposition." Basically, this means the person who checks the remains of a military personnel should they become a casualty.
Mr. John Smith was the PADD designate for Cpl. Smith, his son. Cpl. Smith was a casualty of war.
po rangerbourne Мај 26, 2009
To have sexual intercourse with a chick, where she takes it in both holes. With 2 dicks.
Pussy Ass Double Dick.
Pussy Ass Double Dick.
Leona: i hate you
Rei: Bitch, shut your fuckin' mouth, or i'll tape you to the bed and give you a mighty paddin'
Rei: Bitch, shut your fuckin' mouth, or i'll tape you to the bed and give you a mighty paddin'
po Rei10 Март 12, 2008


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Top Definition
A 15-pack of Vancouver island's own Lucky Lager beer. Thus named for the conspicuous fisherman wielding a large salmon on the side of the 15-pack box. Phrase first originated in Duncan BC.
Just caught me a salmon pack from the liquor store, lets go fishin
gearhead12가 작성 2009년 07월 23일 (목)
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Rick Warren says it doesn't matter what society thinks about marriage these days. Here's why only one opinion is relevant. read more
Page 46 of 127
10 Characteristics of a Man of Integrity
What do you do when nobody is looking? Are you the same person when someone is? read more
How to Lead A Man (or Woman) to Christ
It may sound simplistic, but here are some steps to witnessing to the unchurched. read more
Why You Need to Man Up and Show Her Some Affection
Doesn't your wife deserve it? What are some simple ways that you show affection to her? read more
Could You Be a Modern-Day Job?
Do you have enough fortitude to come back from setbacks like Job did? Or would you simply curse God? read more
Dads, Ask the Holy Spirit to Guard Your Tongue
Are you listening, Christian fathers? None of us is perfect, but prayer can help you watch your language, especially around your kids. read more
9 Things Wives Should Never Say to Their Husbands
This time, it's the husbands' turn. What other phrases have you discovered that cause more hurt than help in your marriage? read more
You May Be Married, but Are You Engaged?
Are you fully engaged in your marriage, or are you simply going through the motions and being comfortable with the status quo? read more
5 Things I Would Do Differently If Raising My Family Again
Like most parents with grown children, Pastor Ron Edmondson would want to change some things about how he and his wife reared their kids. read more
5 Financial Red Flags That Can Sink Your Family
Are you barely keeping your head above water financially? Is it because of one, some or all of these things? read more


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Steve Lewis/Durango Herald
The seniors on the Durango High School girls soccer team are a literal bunch.
Thursday�s calendar, for example, said �Senior Day.�
Accordingly, the DHS seniors had a hand in every goal in a 7-0 Southwestern League-clinching victory over rival Montezuma-Cortez at the Riverview Sports Complex.
�We�ve been a really strong age group since we were really young,� said Durango senior Emily Barney, who scored the first goal of the match in the third minute.
�It�s so great to have all of us together on Senior Day,� said Barney, who was honored in a prematch ceremony along with her nine senior classmates. �It�s really emotional for us because we�ve played together for so long.�
Barney, daughter of Tom Barney and Anne Klein, said the Durango seniors have �supported each other from the beginning.�
Fellow senior Brooke Milliet scored two minutes after Barney, converting a picturesque finish to the upper right corner of the frame after taking a crossing pass from Steffie Wilson.
Milliet assisted on Durango�s next two goals � both of which earned a place in Class of 2012 history.
Milliet�s somersault throw-in deep in the Cortez end went right to a leaping Berkeley Davis, who headed the ball into the net. Her next assist came on an indirect kick that glanced into the goal off the backside of her sister, freshman Lauren Milliet.
�We definitely connected in the second half,� said senior Amanda McAliney, who launched a flurry of DHS attacks from the midfield.
�We wanted to finish ... with a decisive win,� said McAliney, daughter of Mike and Renee McAliney.
The Demons, who scored five goals in the second half, outshot the visiting Panthers 27-2.
�In the second half, we asked the girls to be a little more patient,� Durango head coach Aaron Eldridge said.
�We asked them to move the ball around, and they executed the game plan,� Eldridge said.
Senior Raquel Delgado drew a Cortez foul in the box to set up fellow senior Meghan O�Brien for a second-half penalty kick goal.
Delgado scored herself on a header.
And Delgado, a senior, blasted a shot that rebounded to Sarah Bates for Durango�s final goal in the conference-clinching victory.
Eldridge credited a solid, organized defensive effort by the Demons and seniors Erin Maxwell, Amanda Urban, Amanda Jones and goalkeeper Karlee Mulkey.
�What they did (on defense) was incredibly clean and smart,� Eldridge said. �They set up the attack that made us successful (Thursday).�
The DHS head coach said the Demons benefit from a �wealth of leadership� from the current seniors.
�The only thing is Savannah (Seiter) got hurt, and she couldn�t share this with us on the field,� Eldridge said.
�We would have loved to have seen her play (Thursday),� Eldridge said of the Fort Lewis College women�s soccer recruit.
Seiter, however, led the cheers from the DHS bench.
Parents Janet and Mark Seiter also were on hand to celebrate Senior Day with the rest of the seniors� parents, who turned out en masse.
Durango (10-4-1, 8-2-0 Southwestern League) will learn its postseason assignment Sunday afternoon. The SWL champion Demons likely will host a first-round Class 4A playoff match Tuesday at Riverview Sports Complex.


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Let's Make a Deal is kicking off 2014 in a big way: Big Money Week is back!Winter Preview: Returning shows scoop
Starting Monday through Friday next week, one lucky trader per episode could win up to $20,000 a day. In addition, more than $700,000 in cash and prizes will be up for grabs for other Traders, including the "Big Deal of the Day."
Watch a sneak peek below. airs weekdays on CBS. (Check local listings.)(Full disclosure: TVGuide.com is owned by CBS.)
View original Exclusive: Big Money Week Returns to Let's Make a Deal at TVGuide.com
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Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
Developers of DTC Genetic Testing Are...
The application of genomic technology and R&D strategies to the development of personalized medicine and the enhancement of global food production were among the topics discussed at "ICG Americas" held recently in Philadelphia.
The meeting was co-organized by Shenzhen, China-based BGI and The Children's Hospital of Philadelphia (CHOP).
Genomics offers the possibility of accelerating the identification and assessment of new therapeutic strategies, Huanming Yang, Ph.D., chairman and professor at BGI, explained. When genomic analysis reveals a mutation affecting a biochemical pathway or gene network, a safe drug able to intervene in that pathway may already exist, he added, providing a shortcut to later-stage clinical testing in a targeted patient population.
Jun Wang, Ph.D., executive director of BGI, gave the participants a sense of how quickly the field of genomics is advancing and a glimpse into the future. BGI has sequenced 639 different plant and animal reference genomes, with the oyster genome the most recent to be published. To annotate a genome "is now routine," Dr. Wang said. The company is currently focusing on completing sets of genomes, such as the 50 bird species included in its avian phylogenomic project.
In agriculture, BGI is utilizing genomics to select for desired traits in crop plants. Essentially, said Dr. Wang, the goal is to predict phenotype based on whole genome sequence data—to do "breeding in the computer, then the field." This "digital revolution of agriculture" will begin in maize.
BGI recently announced a collaboration with the Bill & Melinda Gates Foundation that will involve both global health and agricultural development.
The Cancer Genomics and Personalized Medicine project under way at BGI involves building a cancer mutation map and determining the frequency of recurrent mutations and identifying cancer driver genes. Much progress has been made to date in surveying the landscape of somatic mutations and genomic variation in cancer and how they relate to tumor biology. Presenters at the meeting described work under way to identify biomarkers to support oncology drug development and drive the discovery of personalized cancer therapies and methods for predicting tumor response to treatment.
James Watters, Ph.D., head of applied genomics at Sanofi Oncology, suggested that it can hopefully help improve the field's overall track record. About 1 in 20 oncology drugs in development succeed in becoming commercialized, with many failing in late-stage trails; approximately half of the compounds that make it to Phase III studies fail.
Describing next-generation sequencing (NGS) technology as "quite transformative" for translational medicine, Dr. Watters outlined four main approaches for how NGS is being applied to study human tumors: PCR amplicon sequencing, targeted gene panel hybrid capture, whole exome sequencing/hybrid capture, and RNA-Seq. Each strategy has advantages and disadvantages, and when a novel somatic mutation is identified, one of the main challenges is to determine whether it has functional consequences and to understand what the biological and phenotypic effects might be.
Assessing structural changes and complex rearrangements, detecting copy number variation (CNV) with high sensitivity, and performing NGS at the single-cell level represent additional ongoing challenges.
Funda Meric-Bernstam, M.D., medical director and professor, Institute for Personalized Cancer Therapy (IPCT), University of Texas, MD Anderson Cancer Center, described the evolution of genomic biomarker-selected clinical trials at her institution. When possible, patients are allocated to Phase II trials based on a molecular profile composed of somatic mutations linked to tumor types and predicted drug response.
Dr. Meric-Bernstam explained that nearly 600 patients are enrolled in the IPCT Clearinghouse Protocol, which is aimed at establishing a database of frequent somatic mutations in various patient populations and tumor types to assist in the delivery of personalized cancer therapy.
Mao Mao, Ph.D., research fellow at Pfizer and president of the Asian Cancer Research Group, jointly established by Eli Lilly, Merck, and Pfizer, emphasized the importance of identifying actionable mutations as the basis for developing targeted cancer therapeutics. To search for drivers of oncogenetic changes at the cellular and subcellular level, the group screens whole tumor genomes to identify potential drivers and their prevalence in well-annotated cohorts. The initial findings of NGS have shown that "30X whole genome sequencing is cost effective," said Dr. Mao.
Dr. Mao explained that about half of all hepatocellular carcinomas were related to hepatitis B virus (HBV) infection. HBV is a double-stranded virus capable of integrating into the human genome. Dr. Mao's group is taking a whole genome sequencing approach, using paired positive/negative tumor samples to study the hypothesis that HBV integration is associated with cancer.
The group has extracted the HBV integration breakpoints and found that tumor samples tend to have more HBV integrations than nontumor samples. Of 344 HBV integrations in tumor samples, 163 (47.4%) significantly affected the tumor, reported Dr. Mao. Integration breakpoints recurred in six particular genes in more than one sample, suggesting that HBV has preferred integration sites.
Merck Research Laboratories is using molecular profiling to evaluate disease subpopulation and cancer drivers, but one "cannot just rely on [the study of] tumors," said Andrey Loboda, Ph.D., director and head of data analysis, informatics & analysis, who described Merck's cell line biomarker discovery project.
Compound libraries are screened against large panels of cell lines. The cell lines are randomly divided into two sets, a test set and a training set, and this strategy is used to identify biomarkers that can be used to predict the response to a compound. The drug-response profiles developed from cell-line screening well represent treatment responses seen in the clinic, reported Dr. Loboda.
As work progresses to identify genomic biomarkers for molecular subtypes of tumors and to identify drivers of oncogenesis, and as the sample size and database of tumor profiles continue to grow, these efforts will have increasing implications for clinical trial design and for preselective biomarker-driven enrollment, Dr. Loboda predicted.
Noting the publication of five major papers on the breast cancer genome within the past few months, Joe Gray, Ph.D., director of the Spatial Systems Biomedicine Center and chair of biomedical engineering, Oregon Health & Science University, said, "I think we pretty much know chapter and verse the [genomic] landscape of untreated breast cancers." He described 45 regions of recurrent amplification or deletion and approximately 10 distinct subtypes associated with outcomes based on expression and copy number.
Furthermore, he said, "the spectrum of aberrations differs according to subtype." Dr. Gray reported a somatic mutation rate of about 1/Mb (3,000 per tumor) in breast cancer, composed of a few recurrent and many rare mutations.
From a clinical perspective, this information can be used to develop a genomic decision tree, mapping information on treatment response onto the arms of this tree. In this way it might be possible to develop a model of a tumor's intrinsic genomic diversity and to link the genomic aberrations to therapeutic response.
Ultimately, the goal is to discover predictive markers of therapeutic response, and Dr. Gray's group is pursuing a quantitative approach based on screening a range of doses of more than 140 therapeutic compounds in replicates of 54 cell lines. The researchers then use this data and machine-learning methods to develop a predictive algorithm that can select the best drug for an individual patient.
They have developed a methodology for studying pathways in tumors and cell lines aimed at identifying activity signatures and demonstrating subtype specificity for pathway activities. This involves the use of an siRNA interrogation platform for gene knockdown in cells spotted on a culture surface and stained for a specific phenotypic characteristic related to cancer.
Using this approach the group has been able to develop imaging assays for most of the phenotypic characteristics of tumors, reported Dr. Gray. They are now working to improve this model by controlling the microenvironment around the printed cell spots.
The Children's Hospital of Philadelphia (CHOP) and BGI formed the [email protected]
The Center's services will include exome sequencing for the diagnosis of specific diseases including heritable disorders and pediatric cancers. The JGC will also extend the research services it has been providing to support new drug development and clinical trials in compliance with CAP and CLIA standards.
The JGC has five high-throughput sequencers, with plans to scale up to 20 sequencers. It can perform human whole exome sequencing, targeted sequencing, whole genome re-sequencing, ChIP-Seq and RNA-Seq, and NGS data analysis. CHOP maintains a pediatric biobank, with many samples linked to clinical data using an electronic medical record system. The robot-controlled, -20°C DNA sample storage unit can accommodate two million bar-coded samples stored in 96-well microtiter plates or 2 mL tube racks.
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Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
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A deliberate misspelling of Chi-town. Originally given as a tattoo to a customer who was too dumb to check the stencil (2007), then expanded into a massive free tattoo giveaway.
Hey dumbass, you didn't check your tattoo, it says Chi-TONW not Chi-TOWN!
de woofiegrrl 19 décembre 2009
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Division of Diabetes Treatment and Prevention - Leading the effort to treat and prevent diabetes in American Indians and Alaska Natives
Division of Diabetes Sponsored Training
Live Training Sessions
Live Adobe Connect Question and Answer Sessions
Recorded Training Sessions
Recorded Adobe Connect training sessions for Audit 2015 are listed below. Click on a topic to view it. New sessions for Audit 2015 will be posted as they become available.
Resource and Patient Management System (RPMS) / Diabetes Management System (DMS)
IHS Office of Information Technology (OIT) Sponsored Training
IHS OIT offers extensive training on using the RPMS, including classes on the DMS which cover the Audit. These classes are mostly classroom-based, hands on training. For a complete list of classes available, see the OIT National Training Schedule.
Northwest Portland Area Indian Health Board (NPAIHB) Sponsored Training
In addition to hosting classes for IHS OIT, NPAIHB offers three-day classroom-based training on using RPMS/DMS. For more information and a schedule of classes, see the NPAIHB website.


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Serves 6 |
Prep Time 5 minutes |
Cook Time 0 minutes
1/4 cup sunflower seeds, dry pan roasted, unsalted
1/4 cup Eden Extra Virgin Olive Oil
2 cup fresh basil, loosely packed, chopped
1 cup fresh parsley, chopped
3 cloves garlic, chopped
2 Tbsp Eden Shiro Miso
1/2 cup water
Place all ingredient in a food processor or blender and blend until smooth and creamy. Serve over any Eden Pasta.
Gluten-Free, Italian, Japanese Food, Macrobiotic, No Sweetener Added, Oils, Sauce & Gravy, Vegan, Wheat-Free


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Priscilla Gaskins
member for 15 years, 11 months
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I grew up in Clinton S.C. and currently live in Owosso, Mi. I work as a nurse. I love dogs- I have 3 who are my babies. I love to read and enjoy playing piano and flute.Am currently learning to play the violin-at 60 years of age! I love walking through cemetaries and since I found find a grave I spend hours browsing through this. I have found this gives me a chance to visit my parent's graves since i live so far away and can't visit like i should.
I collect books on ghosts and i am trying to get books of ghosts stories from different states and countries- real stories- not made up ones so if anyone has any books from your area on ghosts email me and i will be glad to pay you and send you my address!
New changes in my life- as of Dec 1,2008 I retired from work!!!!!And I really enyoy it!
Since i started this profile I have retired from work and love it.I lost one of my 3 dogs this past June- myBrittany who was my favorite,I am 63 -well 64 nov 28- now.Have been to South Carolina quite a few times since I have retierd.Still love my ghost stories and got to spend a night in a haunted bed and breakfast in Story Indianna!Did not see a ghost but did hear things and had items moved around during the night!!!
2016- new updates on my last update I had just lost my Brittany- well lost another this past June- one of my Cocker Spaniels, Casey- he was 11 yrs old and broke my heart- also broke his sisters heart really bad- they were raised together- same age but six weeks apart- same father but different mothers- she was grieving so that in August I adopted a four month old puppy from the humane society- a lab/Akita mix- beautiful dog and my Lacey acts like a puppy again! Even tho the new one is twice her size she is the boss! They get along great! I am also enjoying my music- still learning violin and play flute in two groups at the music institute plus private piano lessons- besides that volunteer with Red Cross. I have gone to a number of different states helping with national disasters so I stay busy
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Gary Bellile
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any idea how shared grave stone re Mary F Deal and
Willa D Galyardt came to be...
Added by
Gary Bellile
on Sep 08, 2016 2:47 PM
Les Horn
Ben Churlainn Burial Ground, Appin, Argyll, Scotland
I see you have left 'flowers' for all of the entries in this Burial Ground. Have you any connection with those buried there, or their families?
Added by
Les Horn
on Jun 27, 2016 1:09 PM
Les Horn
Ben Churlainn Burial Ground, Appin, Argyll, Scotland
I see you have left 'flowers' for all of the entries in this Burial Ground. Have you any connection with those buried there, or their families?
Added by
Les Horn
on Jun 27, 2016 1:08 PM
Mai Chang
African American cemetery
The African American cemetery is located at Charlestown landing. It's dates form the late 19 th century to the mid 20 th century. My great-great grandfather Moses English should be buried their. On his death record,his son Thomas spelled his name as Inglis. As ever, Joyce
Added by
Mai Chang
on Jun 14, 2016 11:24 AM
Miranda Jayne Hynan
I see you have left flowers on this grave are you a relative of the beltons?
Added by
Miranda Jayne Hynan
on May 12, 2016 2:47 AM
MaryAnn Dierolf
RE: Gaskins Cemetery
Gaskins Cemetery, Accomack County, Virginia... I have connected and added some info to each person
Added by
MaryAnn Dierolf
on Apr 04, 2016 9:06 PM
MaryAnn Dierolf
Gaskins Cemetery
Hi Priscilla I recently "adopted" the Gaskins Cemetery in Accomac County VA after going to do a photo request and seeing many more memorials. Many with the Gaskins name. I have updated what I have found if any are your family please let me know I can update any info or transfer to you. Mary Ann
Added by
MaryAnn Dierolf
on Mar 26, 2016 5:07 PM
Banks-Gregory Cemetery In Kershaw County
Hi Priscilla,
My name is Cindy McClain and I really do like what you have done here on this website. But I wanted to let you know the cemetery that you have named Banks-Gregory Cemetery is actually called Cook Cemetery. At the archives in Camden SC that is the historical name. I know it is out in the middle of no where but my dad,grandmother, and grandfather are buried there and other Gregory relatives. Thank you for your interested in this cemetery. My family and I often go there during the summer months to clean it up a bit. I would like to chat with you in the future because I also I a love for old cemeteries myself.
Thanks a bunch!
Added by
on Mar 13, 2016 1:59 AM
Steven Carroll
Thank You
Thank you, Priscilla for leaving flowers at my Grandfather's grave. It is very much appreciated here in Scotland. xx
Added by
Steven Carroll
on Jan 30, 2016 8:49 AM
Greg Olson
JOhn David
Do you have any connection to John David, who died in 1988 and is buried in the American Cemetery in Cairo, Egypt?
I saw that you had put up flowers on his memorial page.
I'm one of several volunteers helping with the renovation of the cemetery and we're seeking to contact family members of persons buried there.
I have a photo of his headstone and will upload it.
Best regards,
Added by
Greg Olson
on Dec 12, 2015 12:21 AM
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on February 18, 2013 - 8:20 AM
CHERRY CREEK – A Collins man who led a state trooper on a nine-mile chase through this Chautauqua County town said after his arrest that he had been seeking medical attention after injecting himself with heroin.
Donald J. Pfaffenbach, 31, of Quaker Road, was at the wheel of a Chevrolet Blazer that Trooper Keith Mulawka saw at about 8:15 p.m. Saturday parked outside a state Department of Transportation salt barn on County Road 68.
As the trooper approached the parking area, the sport utility vehicle started up abruptly. Mulawka tried to pull it over, but he chased the Blazer for 12 minutes at speeds that peaked at 90 mph.
The SUV stopped on Center Road in Cherry Creek, and the driver ran into a patch of brush, where Mulawka caught him. Pfaffenbach reportedly said he had injected himself with heroin at the salt barn and needed medical attention. He was treated in Brooks Memorial Hospital, Dunkirk, before being sent to the Chautauqua County Jail in lieu of $10,000 bail.
Pfaffenbach was charged with felony counts of driving while his ability was impaired by drugs and first-degree aggravated unlicensed operation, as well as speeding, reckless driving, third-degree fleeing a police officer, resisting arrest and assorted traffic violations.