text:
Nancy and Christopher Latham's bitter divorce proceedings took another nasty turn this week with each seeking additional court-ordered protection from the other, alleging deceit, threats and fear for their lives.
Nancy Latham, a real estate agent and treasurer of the S.C. Education Lottery Commission, filed paperwork Monday in Charleston County Family Court accusing her estranged husband of plotting with his girlfriend to kill her in a murder-for-hire scheme. She wants a judge to keep him away from her and take away his guns.
Banker Chris Latham, who has not been charged with a crime, countered late Tuesday with allegations that he'd been targeted for harm by his wife and her half brother, a convicted triple-murderer who is out on parole. He said in an affidavit that his wife had threatened on numerous occasions to "do anything necessary to 'destroy me' and my career."
Both sides strongly dispute the other's contentions.
The couple is already subject to an October restraining order that bars them from having physical contact with each other or being at each other's homes, as well as from harassing, threatening, interfering with or bothering the other in any way.
Timothy Madden said his client, Nancy Latham, needs additional safeguards in the wake of the failed murder-for-hire plot, saying "she is very concerned for her safety." Madden declined to respond to the allegations in Chris Latham's filing because he had not yet seen its contents.
Chris Latham's divorce attorney, Robert Rosen, said his client is also fearful of his safety and would prefer to try the matter in court, rather in the media. But Rosen said he was compelled to answer the "unnecessary litigation" his wife had pursued of late.
Stephen Schmutz, a criminal defense attorney advising Chris Latham, was more blunt in his assessment.
"There are so many unfounded allegations being made by Miss Latham, all in an effort to publicly trash Chris Latham," he said. "It's shameful and it's wrong."
Deadly plot
The couple's already ugly divorce took a sinister turn on April 5, when Charleston police learned Nancy Latham was the intended target of a murder-for-hire plot. The information was volunteered by Russell Wilkinson, 39, of Louisville, Ky., after he and his wife, Bethany, were pulled over in downtown Charleston with a gun in their car.
Wilkinson told investigators he was hired to kill Nancy Latham and had been conspiring with Wendy Annette Moore, 37, and Moore's ex-husband Samuel Yenawine, 38, of Louisville. All three were arrested, charged in federal court and remain behind bars.
Nancy Latham's motion filed Monday alleges that Moore is her husband's live-in girlfriend and that they conspired to kill her. Nancy Latham made similar allegations in a civil lawsuit she recently filed against her husband and the three defendants behind bars.
Her filing on Monday alleges Chris Latham was involved in or "at a minimum had knowledge of the plot and plan to kill" Nancy Latham and "did nothing to stop it."
According to the protective order filing, Nancy Latham believes she was supposed to be killed before she and her husband's scheduled divorce hearing in April. Before that hearing, Chris Latham insisted on knowing her current address, the document states.
It also states that Chris Latham, who was living on Sullivan's Island, regularly communicated with town officials there in an effort to have Nancy Latham go to the island's police department on certain dates and times. That information was then communicated to the hired killers, the document stated.
Nancy Latham had been fighting a trespass notice filed against her by Chris Latham, who alleged she had sneaked into his Sullivan's Island home, according to an incident report.
The other side
Chris Latham has accused his wife of carrying on a long-term sexual relationship with a man she called 9,000 times over a five-year period, using blocked and cloaked phone numbers to conceal their affair, according to court documents.
He also filed an affidavit in October stating that he was in fear for his life because he was being stalked by his wife and "her paroled murderer brother."
Her half brother, John Hall Cannon, was 18 years old when he was charged in 1971 with killing his mother, stepfather and 4-year-old half brother at their Columbia home during an argument over money. All three were shot to death.
Cannon, now 59, was sentenced to life in prison for the murders, but he was paroled after 12 years behind bars after the state parole board determined he was a reformed man. He walked out of prison a rich man as well, as his grandmother had left him the sole beneficiary of her $1.6 million estate, according to published reports.
In an affidavit, Chris Latham stated his wife has threatened to have Cannon "take care of me." She has also caused a scene at the bank where he works and called employees to disparage him, his affidavit states.
During the divorce proceedings, Latham said, he has been followed, his car has been vandalized and his wife has come to his home after midnight, in violation of the restraining order.
Chris Latham also alleged that Cannon has visited an Atlanta hotel where Latham stays and asked about his whereabouts. He said his wife and Cannon also contacted Moore's ex-husband, Matt Robinson, to conspire to "bring me down" after the divorce, the affidavit states.
"I believe (Nancy Latham) and John Hall Cannon will go to great lengths to harm me," he stated in the document.
During a deposition in the Latham's divorce case, Robinson was questioned about recorded statements he made to Moore about a supposed extortion plot hatched by Cannon and Nancy Latham to hurt Chris Latham. Robinson insisted in the deposition that he made the whole thing up while trying to get his wife to come clean about an affair he suspected her of having with Chris Latham.
Madden, Nancy Latham's attorney, called the claims "a total fabrication" and said there "is not a shred of evidence" that anyone tried to harm Chris Latham. "There was never any evidence that happened," he said.
Nancy Latham's protective-order motion states her husband would have benefited from her death by avoiding nearly $8,000 a month in payments to her for housing, health insurance and other items. It would also have kept Bank of America, where he worked, from learning about his affair with his assistant, Moore — a strict violation of bank policy, the motion states.
The document also states that Nancy Latham fears her estranged husband because he owns handguns, rifles and possibly a shotgun, "none of which were found when law enforcement officials searched the Sullivan's Island residence."
The home on Brownwell Avenue was searched by federal agents on April 11. Latham had lived in the home, which he had leased, for at least a year.
Reach Natalie Caula at 937-5594 or Twitter.com/ncaula. Reach Glenn Smith at 937-5556 or Twitter.com/glennsmith5.


text:
Cubs Potential Offseason Targets: Kelly Johnson
I'm in the midst of one of my hell projects at work, this one just happens to be a little more hellish and is gonna last until December. In order to keep the fun going around here, I thought I'd present some reasonable trade and free agent targets over the next weeks - some of the low-hanging fruit that will probably be more in line with Hendry's budget for 2010. I'm not really going to make a case one way or another, rather just try and open up the discussion. Today's guest is Atlanta Braves second basemen Kelly Johnson....
Braves GM Frank Wren came out today and said Martin Prado will pretty much go into 2010 as the their starting second basemen which leaves Kelly Johnson as prime trade bait. It doesn't mean the Braves have to move him, but he's certainly going to be available for the right price, which can't be a whole lot for a guy with a .692 OPS last year. He's also arbitration eligible and coming off a 2.85M payday in 2009, so it's very possible - let's go ahead and call it likely - that he'll just end up being non-tendered if he's not traded before December 12th.
|4 Seasons
Generated 10/22/2009.
A tough year for Johnson in 2009 and honestly in 2008 he didn't look to great either until he just went nuts in September with a 1.071 OPS to bring his season OPS to a respectable .795 for a second basemen. And he did battle through a knee injury for most of 2008 as well. Defensively, BP has his Rate2 numbers as above average at 108 for his career while UZR over at Fangraphs doesn't think highly of him at all. The Fan's Scouting Report compiled by TangoTiger seems to think of him as average to below average at second base.
On the upside, 2010 will be his age 28 season compared to it being Mike Fontenot's age 30 season and the Cubs could definitely use an infusion of talent under the age of 30. His minor league numbers cumulated to a .832 OPS, but he broke out in 2005 with an OPS of 1.018 in Triple A at age 23 and looked well on his way in 2006 before an elbow injury and Tommy John surgery prematurely ended his season. Actually, Johnson started out as
a left fielder(make that shortstop, then 3b, then left field) in the Braves system and that injury forced him to second
base, but enough time has passed that there's the very small possibility that he could fill a
utility role of some kind. If there's one thing that really makes me think it would be a good idea to go after Johnson, is that he had a BABIP of .249 last year, compared to his .313 career mark. He's either forgotten how to hit a baseball or last year was more about bad luck than anything else. He has a career walk rate of 10.9% which is on the high end and sees 3.94 pitches per plate appearance although both numbers have taken a hit over the last two seasons. Either he's losing his patient approach at the plate or pitchers have been more willing to go after him as his power numbers have dropped off.
There's no way the Cubs would pull off a trade for Johnson and just hand him a job, the only reasonable scenarios are make a trade or sign him after he's non-tendered and then let him compete with Jeff Baker...that is unless the Cubs end up signing Chone Figgins to play second base which I have my doubts will happen. Also any reasonable scenario of bringing Johnson in would mean the end of the Godenot era, but I personally have no problems with that as Johnson is younger, higher upside and has had major league success as a regular.
So how say you TCR readers, should the Cubs make a run at Johnson?
*UPDATE* I should note that Mike Fontenot does have one option year left and at 2 year and 139 service days (according to Arizona Phil) it appears he's going to miss Super Two status by two days
meaning the Cubs could bring him back on an auto-renew and send him to
the minors if there's no spot for him after spring training.
Photo courtesy of PicApp (AiWire Photo via Newscom Photo via Newscom Content © 2009 Newscom All rights reserved.)
Re: Cubs Potential Offseason Targets : Kelly Johnson
"would mean the end of the Godenot era, but I personally have no problems "
Until an unemployed Esther moves into your house.
Re: Cubs Potential Offseason Targets : Kelly Johnson
Trade low level prospect for him and non-tender Fontenot
Trade Aaron Miles for him???????????
Re: Cubs Potential Offseason Targets : Kelly Johnson
Maybe we can add Milton Bradley to sweeten the deal?
Re: Cubs Potential Offseason Targets : Kelly Johnson
Its' funny you say that, that is one of the trades Steve Phillips said he would make if he were Cubs' GM.
Re: Cubs Potential Offseason Targets: Kelly Johnson
This may or may not have something to do with my lifelong man-crush on Sandberg, but I've always liked the idea of, well, a starting 2B, something this team hasn't had in a long time (although we had 2 in 2003, go figure).
I did the same math you did, Rob, when I saw the Prado comments this morning. Didn't realize how far Johnson's bat had fallen, but this guy could be a perfect new project for..... JARAMILLO-MAN!!! (along with everything else he's got to fix)
And one more thing just occurred to me, LF, 2B, Braves..... this guy could be the next DeRosa!! And Jaramillo changed DeRo's life, ergo....
Re: Cubs Potential Offseason Targets: Kelly Johnson
"That whole situation couldn't have been handled better by Kelly. He handled it so gracefully, and it gave all of us who are his best friends permission to root for Prado."
When the Braves removed Johnson from his regular role and then asked him to regain his swing during this Minor League rehab assignment, they were impressed with the dignity he displayed. He never publicly criticized the organization or the decision, which was based on the fact that he'd hit .191 with a .257 on-base percentage in his previous 39 games.
"Kelly has handled all of this like a true professional," Wren said.
I love the guy already...
Re: This is Going to be Awesome
Will there be subtitles?
Re: This is Going to be Awesome
If they want real fireworks they should pair Ozzie with Hunter Wendlestat in studio.
Re: This is Going to be Awesome
"Dat cull by dat umpire was buwshit."
Re: This is Going to be Awesome
HAAAAAAA. Yeah. Always a fan of second language phonetic comedy. Which second language is it you've nailed to perfection?
Re: This is Going to be Awesome
Give me 20 years to learn it..I'll nail Spaniish. Thanks.
Re: This is Going to be Awesome
Laugh if you want, but you know Ozzie won't be able to do this without dropping an f bomb. Or at least "buwshit".
Re: Cubs Potential Offseason Targets: Kelly Johnson
Another Braves 2B worth considering is their utility guy, Omar Infante. He's an enigmatic player who's shown signs of breaking out in the past, has hit well in limited exposure the last couple years and gets to balls up the middle pretty well. At 27, he's right on the verge of that magic year Hendry likes to cash in on. He's got a reasonable contract @ 2.5 million.
Re: Cubs Potential Offseason Targets: Kelly Johnson
I wouldn't condemn him just cuz the braintrust decided to trade him. He put up a 101 OPS+ at age 22 in full time play while Johnson's 3-year stat line reads like a guy falling down a stairway. I think he's got potential to take a step forward into a full-time role. Johnson's intriguing but I'm hard pressed to think of a 2B who has successfully reversed a multi-year decline as marked as his.
Re: Cubs Potential Offseason Targets: Kelly Johnson
I also would prefer Infante over Kelly Johnson because Infante gives you plus defense and can play legit SS and, imo, legit 3B. If you're going to put a dud in the lineup, at least put one in who can play good defense.
But, the problem with Omar Infante is they already have Omar Infante... they just call him Andres Blanco. And it's true and well documented I like Andres Blanco, but I don't like him so much I think they need two of him.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Shit, at one point we had three of him, and the last was acquired by trading Greg Maddux.
Re: Cubs Potential Offseason Targets: Kelly Johnson
I don't see the point, in all honesty, unless it's a free agent pickup. Even then, I'm still not sure I see a point. Btw, I think Kelly started his career as a shortstop, or was drafted as one, was shifted to the OF, then moved back to 2nd when they started developing some guys.
Short of it is ... why spend assets, money and/or talent to add a guy who, while I agree he is better than Fontenot and more of a regular possibility than Fontenot, would be, in all likelihood, a platoon option here, and Fontenot is passable as a platoon option if the team wanted. If he's free and comes really cheap, sure, I'd take a look.
I do expect Kelly Johnson to bounce back, but right now, with the payroll as such, I'd rather focus on more significant upgrades, is possible.
Re: Cubs Potential Offseason Targets: Kelly Johnson
I probably wasn't clear in the original post, but I was suggesting that I think Fontenot would be passable as a platoon option, not as a regular. I think Fontenot is a better hitter than he was this year, although not as good as folks thought he was last year.
I'm also not sure why Jeff Baker is going to fade back into oblivion. I'm not expecting Jeff to be as good as he was down the stretch for us, but I think it's certainly possible that Jeff is finally starting to show some of the immense potential that people expected when he was drafted.
I'm not expecting major changes either, although I expect the Cubs to make a push for one FA acquisition. Heck, I've made the case before that, while Sam Fuld isn't a long term starter, that he fits the Cubs needs enough that I'm not so sure that a Fuld/Baker combination wouldn't be better than what we could likely do at CF/2nd (along with upgrading CF defense) when all factors are considered. Not that I am expecting Fuld to get that chance (and have heard it several times that he's only a backburner option). Short of it is, for all the talk about a middle of the order bat addition, I think the Cubs best chances to help the middle of the order will come from Jaramillo helping Soto/Soriano get back to form.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Best case solution:
Let Tony Thomas start the year in Iowa
Let Fonty and Baker platoon 2nd base in 2010
If Thomas shows he is ready, then you can trade/non tender Fonty and Baker next offseason.
Trade for JJ Hardy
Re: Cubs Potential Offseason Targets: Kelly Johnson
Best case solution: trade Bradley for Utley, Philly also gives us some cash.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Well now the deal is just getting ridiculous.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Fontenot has had his chance and failed. Not only with the bat, but idiotic baseball sense last season. He just needs to go, period. And as Rob says, Fontenot will be 30 next season. How much more improvement can one expect? I would non-tender him.
Unless they're thinking Miles is going to actually do something here, I would think they have to bring in more competition at 2b for Baker. I see Baker as more of the utility guy who starts 1/3rd of the games at 2b unless he proves he's better than that. He has the upside to hit 15-20 hr's, but despite his nice run so far as a Cub, he's still very unproven as a big league starter in my book.
Miles' shot with the Cubs might hinge in part on how much of Bradley's contract they have to eat. We just heard Ricketts has laid down the law with Hendry on how much of a contract we can eat, so maybe the best shot we have to dump Miles is to trade him for another contract.
Re: Cubs Potential Offseason Targets: Kelly Johnson
And these people who expected Baker's immense potential to come to the forefront were his mom and who else?
Re: Cubs Potential Offseason Targets: Kelly Johnson
They got Ascanio in the Infante plus Ohman deal on 11-12-07. Ascanio (plus Kevin Hart and milb 3B Josh Harrison) was flipped to the Pirates in the Grabow/Gorz deal
Infante will get $1.85 million this year and $2,225,000 in 2010, and the Braves hold a $2.5 million option for 2011 with a $250,000 buyout. He can earn additional performance bonuses each year based on plate appearances from 180-580: $300,000 this year, $775,000 in 2010 and $1 million in 2011.
Re: interest in chapman?
Can we trade Bradley to Cuba for him? Oh that doesn't work...can we give Bradley to Chapman in exchange for Chapman? No? Oh, ok, then we're not getting Chapman.
Re: interest in chapman?
Can we have Chapman wait outside Bradley's apartment building and ask for his autograph and then...nevermind.
Re: Cubs Potential Offseason Targets: Kelly Johnson
why get kelly johnson when you already have fontenot/baker? ugg.
fontenot/baker makes more sense to me than kelly johnson. johnson's upside is matched by the 2 guys he'd be replacing at a similar price to the 2 combined. the word "upgrade" doesn't come into the equation with johnson involved, imo.
he's got a very unpolished/ordinary swing (constantly changing last season, very long through the zone for a chunk of it...ever-changing foot work at the plate). i dunno where/how he can squeeze much more out of it. hell, him and jeff baker are very similar players, imo.
Re: Jim Callis chat
No way Bryce Harper falls out of the 1st round.
The new rules takes away most of the leverage for guys like Harper. Washington can draft him #1. Then get the #2 pick if they cannot sign him.
I really wish Baseball would go with a worldwide draft, that players would have to sign up for. Just like every other professional sports league in America.
Re: Jim Callis chat
see Harrington, Matt
Re: Jim Callis chat
Doubt he is "toolsy" enough or looks impressive enough in a uniform for the Cubs to reach on.
If Golden Tate is still there though. He should probably get over slot for his athleticism.
Re: Jim Callis chat
Keith Law also noted that he thought Castro, in a few years, could post a slugging percentage above .440, which would be awfully sweet. That said, that's a few year's down the road. Compared Castro's bat to Soriano's, but with much better contact ability.
Re: Jim Callis chat
I'm glad to see Vitters move down on somebody's list.
Vitters is fine long-term (maybe his hand will heal some day) but there are at least four position players who seem to be on a very fast track right now--Castro, LeMahieu, Lee and B. Jackson--and they can all use their gloves, which Vitters hasn't shown.
Speaking of guys who are still dining out on their reputation as of the day they were drafted: Cashner had another so-so outing today.
Re: Jim Callis chat
vitters is doing everything people expect him to do so far, but his obvious lack of being able to play 3rd is killing his "prospect value."
i'd like to know if he's RF-capable, myself. when he was drafted his arm was just raved over...which is pretty much why it was assumed he could just have his glove-work corrected to match up to the arm. his range has always been suspect, but his arm was rubber-stamped as a no-doubter.
i doubt the cubs will move him any time soon, but he's doing nothing to let people think he's going to play 3rd for a living. everyone likes his bat, but a lot of people are working on the assumption his next (and eventual) stop is 1st.
Re: Jim Callis chat
The fact that he walks at Colvin-esque rates lead me to believe he will bust.
Best case is probably Shea Hillenbrand 2.0
Maybe we can trade him while his value is high? How about Vitters for Weiters?
Re: Jim Callis chat
yeah, he's a hell of a free swinger to a fault. he's got a lot of pop, though. one of the few kids in the system with a legit shot at 30-40HR season upside.
Re: Jim Callis chat
Reading around in BA, I find this October 1 item in which Callis suggests that Castro may not be the only position player ahead of Vitters:
Navin (NorthSideBaseBall): So if I read your Brett Jackson response correctly ("no lower than 3"), you'd rate Jackson as a better prospect in the MWL than Josh Vitters? I'm surprised by that.
Jim Callis: I would have been to before I started working on the list. But everyone loved Jackson, and he's going to have more value if they both develop as hoped and he's playing center field while Vitters is playing first base. Not sure which way I'll go after delving into this further for our eventual Cubs Top 30.
Re: Jim Callis chat
That's funny, I did read #19, that's what got me going on the whole subject, but I assumed he was talking about Jay Jackson.
Re: Jim Callis chat
Jim Callis: "I would have been to before I started working on the list"
Nice to see English is not Callis' native language.
Re: Jim Callis chat
It's his second language...give him a break.
Re: Jim Callis chat
Oh, I probably shouldn't take the bait, but what the hell--it's a Friday. Of course it's okay to mock Jim Callis or any other English-speaking journalist/publisher for English gaffes. They're professional, public communicators in America. I'm gonna go out on a limb and guess that 90% have college degrees. Clearly they should know better.
Mocking foreign baseball players for not speaking English well, however, is just lame. Communicating to the media in a second, and sometimes third language can be no easy feat. And while I'm not saying most ballplayers are dumb, I am saying that many are uneducated. I don't think it's cool to make fun of someone's language skills because they make a lot of money.
Someone intimated earlier with the "give me 20 years and I'll nail Spanish" that Ozzie should speak better English. And yes, it's fine to expect a manger to communicate clearly with the media. But he does speak English, however goofy it may sound to you. That doesn't make it cool to make fun of his accent.
Mocking foreign speech on a blog isn't exactly the same, but it's the little sister to the nonsense that went on when Clemente was in Pittsburgh in the 60s and the papers quoted him phonetically to call out his accent. Just bad form.
Re: Jim Callis chat
Of course things today are just like the 1960's.
Re: Jim Callis chat
Should read "I would have been, too, before I started working on the list"
So I'm an english nazi, so sue me........
Re: Cubs Potential Offseason Targets: Kelly Johnson
Great idea. Why would we want good players when we can get Kelly Johnson?
I know, I know, this is just an idea being batted around on TCR, but why not Orlando Hudson?
Re: Cubs Potential Offseason Targets: Kelly Johnson
With economics being what they are, I imagine we will see quite a few unexpected Non-Tenders.
Hopefully none of them end up with 5/55 and NTC's from us.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Wait...wait...you guys are brushing aside that Johnson does not have 1.000 OPS potential with OUR NEW DAVE DUNCAN OF HITTING????!!!
C'mon men!
This is a new era!!!
Re: Cubs Potential Offseason Targets: Kelly Johnson
Re: Cubs Potential Offseason Targets: Kelly Johnson
Beautiful... just beautiful.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Dave Kaplan is having Jaramillo and Hendry on WGN Radio Sportscentral tonight, his show just started at 7pm Chicago time.
Jaramillo is going to be on from 7:15 to about 7:30, Hendry from 7:35 'til 8PM.
You can listen in on the Interwebs:
Re: Cubs Potential Offseason Targets: Kelly Johnson
strasburg spent an hour today taking himself out of the running for AFL mvp...
2.2 ip, 7 h, 8 r, 7 er, 1 bb, 4 k, 3 hr, 60 pitches, 36 strikes...
Re: Cubs Potential Offseason Targets: Kelly Johnson
You're not allowed to correct your spelling errors until after I've made a snide comment.
Re: Cubs Potential Offseason Targets: Kelly Johnson
and mr stasburg agrees.
Re: Cubs Potential Offseason Targets: Kelly Johnson
Hey Crunch, I finally got around to watching Sugar last night. Good flick.
Re: Cubs Potential Offseason Targets: Kelly Johnson
yeah...it's one of my favorites now. it's not a mega-classic, but it's a fresh story told well.
Re: Cubs Potential Offseason Targets: Kelly Johnson
ROB G: If the "Super Two" cut-off is indeed 2+141, here are the "Super Twos"...
Joey Devine, RHP - A's 2.+171
Brian Wilson, RHP - Giants 2+169
Rajai Davis, OF - A's 2+167
Alex Gordon, 3B - Royals 2+162
Mike Adams, RHP - Padres 2+161
Tom Gorzelanny, LHP - Cubs 2+161
Omar Quintanilla, INF - Rockies 2+159
Jesus Flores, C - Nationals 2+158
Hunter Pence, OF - Astros 2+156
Jason Hammel, RHP - Rockies 2+153
Matt Garza, RHP - Rays 2+149
Tim Lincecum, RHP - Giants 2+148
Nick Masset, RHP - Reds 2+146
Jeff Karstens, RHP - Pirates 2+144
Matt Albers, RHP - Orioles 2+141
Carlos Gomez, OF - Twins 2+141
Dustin Nippert, RHP - Rangers 2+140
Adam Jones, OF - Orioles 2+139
Mike Fontenot, 2B - Cubs 2+139
Brandon Morrow, RHP - Mariners 2+139
Micah Owings, RHP - Reds 2+139
Mark Reynolds, 3B - Diamondbacks 2+138
Jarrod Saltalamacchia, C - Rangers 2+137
Allberto Callaspo, INF - Royals 2+135
Glen Perkins, RHP - Twins 2+133 - see NOTE
Anibal Sanchez, RHP - Marlins 2+133
Ben Zobrist, INF - Rays 2+133
Joe Smith, RHP - Indians 2+132
Fred Lewis, OF - Giants 2+129
Jeremy Sowers, P - Indians 2+128
Mike Pelfrey, RHP - Mets 2+122
NOTE: The Twins optioned Glen Perkins to AAA after he was reactivated from the DL in September, thus keeping Perkins from being a "Super Two" post-2009. So Perkins will likely file a grievance and he could win, but that won't change the cut-off once it's set. That's because a "Super Two" can be a FA if outrighted to the minors prior to signing a contract for the following season, and it could cause a problem if a player is designated "Super Two" and then has it removed, because a club could claim it would have outrighted the player if the player had not been a "Super Two."
Also, while it appears that Gorzelanny easily qualified as a "Super Two" by virtue of MLB ST, he actually just barely qualified because he accrued only 87 days of MLB ST in 2009, and a "Super Two" must accrue at least 86 days of MLB ST in that season in order to qualify as a "Super Two."
One other thing. Note that Rajai Davis is a "Super Two," and so he might be available in a trade in case the Cubs choose not to bring Reed Johnson back but are looking for a speedy OF who can platoon with Fukudome and hit lead-off. .
Re: Cubs Potential Offseason Targets: Kelly Johnson
Submitted by Rob G. on Fri, 10/23/2009 - 11:17am.
not that I care, but shouldn't that read 2+171 and so on down the line? I only ask because I was about to put it the TCR Friday notes.
ROB G: Thanks for catching that. I'll fix it.
Re: Cubs Potential Offseason Targets: Kelly Johnson
There are a few things to point out about Johnson's season that rarely gets mentioned. In June when he lost his job to Prado he was playing through a wrist injury. He spent almost a month on the DL and rehabbing in AAA. He returned after the break to post a .851 OPS (although in decreasing playing time once Infante returned even though he was pretty bad), but he looked really good and his patience at the plate returned. I would guess that he will return to being a slightly above average second baseman next season. Beware of his streakiness, but at the end of the day you will look up and he will post solid numbers. Defensively, he can either be average or below average. He is really atheletic and can make great plays. His errors come in bunches and since he is not a natural, long layoffs in playing time and rust will show. He is a smart player though; never seen a bad relay throw and probably one of the best baserunners in baseball.
Recent comments
Meh, I messed that up. Mets are in.
Cards and Giants can still tie though.
Kershaw gets hurt by his defense and gave up 2 more runs. Blach has 8 shutout innings.
Mets already won as did Cards.
tomorrow is gonna be helluva fun if Giants hold on. We're all rooting for a 3-way tie I presume.
good news is now 5 K's for Lester through 4 (in a quest for 200 for season). Bad news is he's already at 86 pitches.
be curious how long Maddon sticks with Lester to try and let offense get back into it and get him the win (4-2 as I type, was 4-0)
Fwiw, he needed 2.1 IP to cross 200 for season so he got that at least. He also needs 9 K's for 200K's on season and he has 4 through 3.
cubs score 2 runs thanks to predictable reds pitching and horrible CIN defense...cubs only down by 1 now. heyward even got a gift 2rbi double out of an easy popout. neat.
something named Ty Blach has outpitched Clayton Kershaw through 6 innings (1-0 Giants).
not that finishing 2nd place will matter much nor did this game, but have to think if Hendricks pitches well tomorrow, he could leapfrog Lester in Cy Young voting. Don't see anyway Scherzer doesn't win it regardless and it doesnt' look like Lester has any incentive clauses that matter. Also might give Cueto some votes.
Rather remarkable how many teams have really good 1-2 options this year.
Nats: Scherzer and Roark (and Strasburg was great before injuries)
Cubs: Lester and Hendricks (and Arrietta is still damn good just not as consistently lately)
pretty much what I'm gathering from this thread is that it doesn't matter who you play in 5-game series, but no one wants to have to deal with Cardinal fans if we end up losing.
I can respect that.
first game for lester giving up more than 2 runs since july 24th. hell of a run.
doh, yes...dunno what happened there. jake arrieta is all "bro wut?"
lester going for #20...cubs haven't had a LH (thanks jpep for the correction) 20 game winner since d.ellsworth in 1963.
fwiw, all the games are free on mlb.tv
Short rest for MadBum would be 2 days. WC game is Wed., Games 1 & 2 are Friday/Saturday.
A left-handed one...
J-Hey not finishing with an offensive onslaught.
If Geoff Blum could be a Playoff hero, there is hope still...
Giants scare me. I think you're wrong about Bumgarner, he would pitch on short rest for Game 2 and then full rest for Game 5. Cueto would go Game 1, then short rest in game 4. Add in some really tough outs in that lineup and I want nothing to do with them. With that rotation they can easily steal a series.
Cards are a tough matchup. The rivalry evens out their comparable lack of talent. And like someone said, they love HRs, which is how to beat the Cubs. The upside is that I would feel really good about Lester twice against STL.

subset: commoncrawl


text:
Poverty is not an issue that lawmakers have been eager to discuss in a political environment dominated by budget cuts and deficit reduction. However, in his State of the Union address Tuesday night, President Obama not only addressed the rising poverty rate, he offered a partial solution.
"Tonight," Obama said, "let's declare that in the wealthiest nation on Earth, no one who works full time should have to live in poverty, and raise the federal minimum wage to $9 an hour."
Putting a little more money in the pockets of low-skilled workers will not end poverty in America, but it will help get some people off of government-funded food assistance and other programs for the working poor.
However, there was more behind the suggestion of raising the minimum wage. In asking Congress to raise the standards of the working poor, Obama sent a message to CEOs across America that corporations should not be enjoying record profits by paying people so little that the government has to help buy them food.
Obama added, "This single step would raise the incomes of millions of working families. It could mean the difference between groceries or the food bank, rent or eviction, scraping by or finally getting ahead. For businesses across the country, it would mean customers with more money in their pockets."
Obama's call for raising the minimum wage was not as comprehensive as President Lyndon Johnson's War on Poverty as laid out in his 1964 State of the Union address. Yet it highlighted the fact that there are things government can do to improve living standards for the poor.
Conservatives have put the focus of America's problems on the federal deficit, which exploded when the George W. Bush administration started two unfunded wars and gave away the Clinton-era surplus in the form of tax cuts, mostly for the wealthiest Americans. Combined with policies that propagated deregulation, a new attitude overtook the country. Making money was all that mattered.
Lost in the excesses of Wall Street that flourished in the 1980s was generation of workers whose shrinking wages created an ever-widening gap between America's rich and poor.
Low-paying jobs are a symptom of a bigger problem in America. Raising the minimum wage would not be an issue if employers in the 21st century had not forgotten the business plan of automaker Henry Ford, who knew the best way to succeed was to pay his employees enough money to be able to buy the products they were making.
Workers making $9 an hour today are still earning less than middle-class wages. But a pay raise will ease some of the financial struggles of the working poor.
Sources and more info:
US government poverty guidelines
Full transcript of President Obama's 2013 State of the Union address


text:
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Developing films the open source way | Opensource.com
Developing films the open source way
In a world where movies are produced on budgets of hundreds of millions of dollars, at a time when studios expect a huge return on their investment, in an industry where the opening weekend can make or break a film--one man refuses to live by society's (or the movie industry's) rules. One man is willing to put it all on the line and do something different. Something daring. Something... free.
That man is Mike Schneider.
That film is Night Of The Living Dead: Reanimated.
As a horror and zombie film buff, I'm familiar with George Romero's classic 1968 film, Night Of The Living Dead. And also aware of the mistake made by Romero and his colleagues when they released the film without a copyright notice, accidentally making their hard work into a public domain property.
In 2008, Mike Schneider took that work and, in collaboration with other artists and animators, derived a new work based on Romero's film. They replaced the entire visual experience with a series of still drawings, cartoon animations, stop-motion animations, and other visual interpretations of the original work. And in a manner very similar to open source development, Mike collaborated with his team--vetting their submissions, putting them together, and producing a new work. I had the chance to email Mike about this project, and also to interview two of his associates, Rob Hauschild and Peter Gutierrez, on A Little Dead Podcast, where I review genre films, games, books, and more. We talked about the motivations, the goals, and the path to get from the concept phase to a successful project.
But a project is not very successful without an audience. And in the case of a movie, that audience has to be willing to either purchase a ticket to see the film, or else buy or rent the DVD or Bluray disc, or stream it from a pay service like Netflix. A willingness to pay the price to watch the film is the barrier that the producers have to overcome.
But what if that price were free?
Another group with whom I've had the chance to talk is Fewdio, a production group made up of film industry professionals with a shared interest in horror and short films. They produce short horror films and release them on YouTube and on their own website. On my podcast, I had the pleasure of interviewing one member of Fewdio, writer and director Paul Hungerford. He spoke about how their goal was to make films available to their audience freely, while still being able to sustain a business by providing a production DVD that the audience would buy.
With Night Of The Living Dead: Reanimated you can legally download the film, burn a copy of it and share it with your friends--all without having to pay a single cent. Similarly, with Fewdio you can go online and watch all of their works for free. So how does either team plan to make money, or at least cover the costs of producing the works in the first place?
By producing a quality film, combined with enough extras to make the customer want to pay for a copy. The idea is simple: let the audience see the work and, if they like it enough, allow them to buy a production DVD or Bluray that contains not only the film(s) but also extras, things that the viewer would like or which enhance the film. Such things as commentary tracks, foreign language audio, behind-the-scenes films, and more.
And while a fairly radical idea, this is not necessarily a new one. Back in 2006, the band Harvey Danger released the first CD of their CD set Little By Little... as a free download on both P2P networks and as a direct download from their website. Their business plan was simple: if you like the first CD, then purchase the set to get the rest.
The key idea to take away here is freedom: freedom of the consumer to see what they're paying for before they spend their money. This empowers the viewer, letting them control where they spend their money. Rather than spending their money up front before watching a film, they can see the work for free. As a result, more people are likely to watch the film, or listen to the music.
And this leads to a benefit for the producers: greater market penetration for their work. With legal and financial barriers lowered or removed, a greater number of potential customers will be aware of the work at a lower cost to the producers. As audiences share the works with their friends, word-of-mouth marketing can easily and quickly make more people aware of the work and increase the potential base of paying customers.
Another derived benefit from this sort of arrangement is that the quality of the work should tend to go up as a result. By opening up their work for free review by their audience, producers will have to invest more into the quality of their product--and not their marketing--to get their audience's money. Everybody benefits when the quality goes up, and the market itself grows.
You can listen to the interview with Paul Hungerford and the one with Peter Gutierrez and Rob Hauschild on the podcast website. The podcast is freely available; Each episode is released under Creative Commons share and share alike (By-NC-SA) licensing. Listeners can freely download, copy, and share it as well. And my hope is to spread the word about projects like Night Of The Living Dead: Reanimated and Fewdio to as many people as possible.
Starting with you.
4 Comments
This is a great idea and another film I have come across that uses this method of legal free download is Samuli Torssonen's film Star Wreck, which is a feature length parody of Star Trek and Babylon 5 with suprisingly good special effects! As was mentioned in this article, I also first downloaded the film, liked it so bought the DVD (with extras) from Amazon.
I just came across an article that mentions a similar idea, only it puts it in the context of a classroom, among other things, in addition to movies.
There are several real good animation films out there made with the open source software of blender.org. A real must-see is the last demonstration of the power of the software in the hands of skilled artists: http://www.sintel.org/wp-content/content/download.html
I too feel that this strategy can actually work in the current time where all want to have some great things like that. But at the end I just prefer to download movies from secure movie hubs.


text:
Adrian Lamo on the line there. Lamo also told me he submitted those chat logs between him and Manning to wikileaks and it's their decision whether or not they want to publish them ...
The allegations are false. If you continue to print false material, there will be repercussions. Mr. Lamo is by no means a credible source. It is disturbing that you entertain him.
I don't have time to deal with CNN, and you want me to play 20questions with a Lamo puppet from 'daily tech'?
Adrian, it was interesting having you in the world. Sorry that things worked out this way. You have made it pretty clear that you are not to be leaned upon; it's sad that someone so very desperate tried. He did not understand it, and now he's locked up.
If god gives me the opportunity to bump into you one day, I'll be presented with many different ways to taking your worthless life. The bright side for you is that you get to choose which way I take. Any suggestions?
quote: And Wikileaks cannot be blamed for outing Lamo as a source, because he had already outed himself.
quote: It's sad but in this day and age these types of leaks are the only way to hold those with absolute power accountable.
quote: With the potential of at the same time compromising Americas security costing lives? Thats an ignorant stance. I myself and many other Americans pay everyday for this type of stupidity in these matters. Get a clue!
quote: Give me a break it's diplomatic transmissions not battle movements. I like how people are all concerned about this costing American lives but they have no problems supporting two wars that are in fact with out a doubt costing American lives for nothing more then what is now Nation Building/Private Security for corporations.


text:
on February 2, 2013 - 1:00 AM
Theater Station closing is a giant step backward
We have reached a sad milestone for Buffalo transit, the closing of the Theater Station. The station has served theater patrons, area residents and workers for more than 25 years, but will close permanently on Feb. 18. Many will be surprised to hear this because there has been very little public outreach about this decision. The short notice being given now will be the first time many Theater Station users will hear about the closing.
The station is being eliminated to make room for cars that will share the right of way with Metro Rail along Main Street. This is being done on the 600 block this year, with near-term plans to extend the arrangement to the 500 block and eventually farther south. The change will allow Shea's patrons who arrive by car or livery to enjoy curbside convenience, but everyone arriving by train, including the elderly, disabled and families with small children, will now have to make their way from Fountain Plaza.
We are saddened that the 1,200 patrons who use Theater Station every day will from now on have to use Fountain Plaza or the Allen/Medical Campus Station if they want to use the light rail.
Douglas Funke
President, Citizens for
Regional Transit, Buffalo


text:
Lexington, NC -- A Lexington restaurant chain is taking its biscuit business to Whole Foods Market.
The Business Journal reports, the owner of "Biscuit King" restaurants said she wanted her products sold at Whole Foods Market, and she got it!
Cathy Dunn said she created a healthier version of her biscuits, using unbleached flour and hormone free buttermilk.
Dunn says she signed a vendor agreement to deliver dozens of "Cathy's Homemade Biscuits" to eight Whole Foods stores across North Carolina.
In the coming months, she say's she'll be ready to launch the product through the chain's South region.
The Business Journal


text:
No, Robert Pattinson says the hardest part of his breakup with Kristen Stewart was the aftermath, when he was asked to talk about his Twilight costar's cheating scandal in public.
"S––– happens, you know?" Pattinson tells British Esquire in its September issue about Stewart's fling with director Rupert Sanders. "It's just young people … it's normal! And honestly, who gives a s–––?"
Well, lots of people did. And that, says Pattinson, was indeed difficult.
Steve Granitz / WireImage
It's been two years since that scandal, and more than a year since the couple split for good after a brief reconciliation. And Pattinson continues to move beyond his Twilight days – personally and professionally.
For one thing, though still "a relatively solitary person," he's learned to deal with fame better, and isn't as bothered by the paparazzi.
"There was a time, three years ago, when I didn't know where to live where I wouldn't be trapped in my home, you know?" he says. "But I worked it out. It's not that big a deal in the end. Half of it is in your head."
He's also been taking challenging roles in movies from auteurs David Cronenberg, Werner Herzog and Anton Corbijn. That's been fulfilling, though not without its moments of anxiety – like when he had to film a sex scene with Julianne Moore for Cronenberg's Maps to the Stars and things got … strange.
"I noticed I was sweating. Like really heavy sweat," Pattinson says. "I remember trying to catch the drops as they fell onto her back. It was weird. Huge splashing drops. At one point she turned around and said, 'Are you all right?' "
Pattinson is indeed all right. "I know what makes me happy, if I'm feeling down: doing things that make your friends jealous," he says of life these days. "It really works! I just say, 'I'm working with David Cronenberg,' and they go, 'Oh really?' I love that."


text:
Managing IIS 7 with Windows PowerShell
- Posted: Nov 14, 2006 at 11:17AM
- 6 comments
Loading user information from Channel 9
Something went wrong getting user information from Channel 9
Loading user information from MSDN
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Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
Oops, something didn't work.
I really love the C# feeling of it with the support for hashtables, switch statements that can case on regular expressions, array slicing and the script blocks that can be stored as data and then later executed.
sc00ter wrote:Now i'll have to check out IIS. I never really used IIS because it didn't support PHP.
<Did you noticed that Bill mentioned that we could get greater throughput but that the network was throttled?>
When I did the demo in the keynote we thought we had a problem because after I turned on IIS7 output caching - the CPU stayed at 100%.
Now doing a keynote demo - you can't have any glitches and having things break the day before the event - is a VERY VERY bad thing. So there I am looking at my keynote demo not working before my very eyes.
I ran off and was examining the code looking for flaws. I couldn't find any so I tried to enable caching a few more times and nothing worked. I was starting to feel a little ill when I looked up at the gauges and noticed that they were ALSO BROKEN. Things were getting WORSE.
Instead of showing 400+ Requests per second, the gauges were showing about 3000. Arrrgggg! I started trolling the system to see what was broken when it suddenly dawned on me that maybe the data was correct. At the show, I had an isolated network so what was happening was that the stress machine just zoomed and the servers had REALLY gone from 24 to 3000 RPS - over 100x improvement. Awesome - truly awesome. It is incredible to have an improvement soooo dramatic that you think your instrumenation is broken!
BTW - that is why the demo is different in the keynote address - it wasn't interesting to show CPUs stay at 100%.
Jeffrey Snover [MSFT]
Windows PowerShell/MMC Architect
Visit the Windows PowerShell Team blog at: http://blogs.msdn.com/PowerShell
Visit the Windows PowerShell ScriptCenter at: http://www.microsoft.com/technet/scriptcenter/hubs/msh.mspx
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


text:
Top Definition
A rigid dressing, usually made of gauze and plaster of Paris, used to immobilize an injured body part, as in a fracture or dislocation. Also called plaster cast.
Gonnae let me right a menshie oan yer stookie?
автор: Jazzy Spazzi 10 декабря 2004
Trending Now
Can you define these popular missing words?
The word Stookie is used to refer to a Headbutt in Glasgow, Scotland and its satellite towns.
During the fight i layed a stookie on him.
автор: TrekChick 2 октября 2009
originated from the latin word stükié
adj; stupid,idiot
v; get trashed;intoxicated
adj; stupid,idiot
v; get trashed;intoxicated
adj; You're a stookie for cheating on that test.
v; I got so stookied last night, i don't even remember what happened.
v; I got so stookied last night, i don't even remember what happened.
автор: dee89 8 февраля 2009
POOP; a shit; crap; a non wet dookie.
"Don't go in there! I just made a stookie."
автор: number1shitter 16 августа 2009
Similar to wordstook, this is a term for a Honda S2000. While stook is the spoken form of s2k (s too k), stookie is another form.
check out the awesome stookie over there!
автор: stookmaster 22 июля 2003
Mandy's dookie that she catches and leaves in the trash can...face up, with peanuts and vegies in it. Looks like splatter painted vegetable soup. Sometimes there may be hay in it too.
Mandy got drunk and put her stookie in the bed and you licked it up off the pillow.
автор: BeatRice Holetapp 17 марта 2005


text:
Film Studies
Westminster's Film Studies Program
Why Study Film at Westminster?
The Film Studies program at Westminster offers an interdisciplinary perspective on the multifaceted and complex medium of film. Film blends the arts of words, pictures, theatre and music; studying these elements builds awareness of how film uses narrative and rhetoric to tell stories and influence beliefs. The ability to think critically about film helps us develop a critical awareness of our world and how it is represented.
The program includes core courses in both film literacy and scholarship. Students will explore the interdisciplinary potential of film, investigating both the elements that comprise film as well as film's relation to cultures. Ultimately students will be prepared to:
The Westminster Difference:


text:
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
Teva spinoff CleveXel Pharma is partnering with small molecule-focused Israeli firm Dynamix Pharmaceuticals to develop a dual-mechanism SYK/JAK molecule, DNX-04042, in rheumatoid arthritis (RA). The product, which is orally active, is Dynamix' lead development program.
Through this collaboration, the companies hope to bring the RA project to a clinical proof-of-concept stage. Preclinical development is currently planned for early 2014, and the first clinical trial is expected to start in 2015.
According to the firms, DNX-04042 is a oral, small molecule inhibitor of both SYK and JAK3 with significant selectivity within the JAK-family and across the kinome. The investigational treatment exhibits over 1,500-fold selectivity in cells for JAK3 over JAK2 inhibition. DNX-04042 reportedly has demonstrated excellent safety in a preclinical MTD study and a very strong anticancer effect in a mouse xenograft study of B-cell lymphoma.
"For CleveXel, the partnership will innovate in inflammatory disease, potentially also in oncology," said the firm's CEO Christian Bloy in a statement. "JAK3 and SYK represent new targets that are extremely interesting in order to develop an orally administered product."
CleveXel, which was formed after the management/buyout of the Teva Development Center located in Maisons-Alfort (Val de Marne), France, says this is the fourth molecule in its product portfolio since the beginning of 2013.
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text:
October 17-21, 2016
Oct. 17, 2016
Find the Sun!
Welcome to today's game. Today we have learned a lot about the star we call the Sun but did you learn enough to able to pick out the Sun when we hide it amongst a bunch of other stars?
Based on your knowledge of where the Sun lies in our galaxy move your cursor around the image below until you locate the most likely spot where the Sun could be. Check the bottom bar of your browser for the clues. When you think you have the correct answer click the button on your mouse.
Move on to the next clue
Meet the Scientists | Solar Glossary | Contact Us


text:
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
As Immunotherapy Revolutionizes the Cancer Treatment...
Protein therapeutics is still a relatively new class of drugs. Even after several highly successful market launches (e.g., Herceptin), our knowledge of protein drug distribution remains limited. Historically, development of protein therapeutics was geared toward candidates with the highest affinity to the target antigen or ligand. This, however, may not always be the best strategy to achieve the desired efficacy and toxicity profile.
As an increasing number of protein therapeutics moves through development, pharmacokinetic evaluation of these therapeutic agents becomes more important. For chemical entities, such evaluation typically involves the determination of four critical parameters: clearance, volume of distribution, half-life, and bioavailability.
For proteins, especially those targeting solid tumors, such mechanistic studies may be particularly complicated. There are a number of issues unique to the pharmacokinetic evaluation of protein therapeutic agents. The distribution of biomolecules depends not only on the properties of the molecule itself (e.g., charge, size, binding affinity, and dose), but also on target tissue characteristics (e.g., vascular and interstitial volumes, vascular permeability, target expression level, and pressure differences between vascular and interstitial spaces).
Endogenous production of antibodies and dynamic changes in surface receptors can also affect protein drug distribution. Further complications arise from our limited ability to assay protein drugs and to distinguish between active and inactive forms in vivo. Consequently, the potential of pharmacokinetic investigations of protein therapeutics is still unclear to many scientists. On the other hand, a lack of knowledge and insight about drug disposition may result in lost opportunities to develop more efficacious clinical candidates.
At the AAPS meeting in October, several scientists talked about their novel models for early and accurate prediction of metabolism and toxicity of investigational compounds. According to Gregory P. Adams, Ph.D., co-leader, developmental therapeutics program at Fox Chase Cancer Center, "Our study was the first systematic evaluation of the effects of affinity on in vivo tumor targeting.
"We utilized a series of intact IgG molecules with varying affinities against Her2. High-affinity antibodies such as Herceptin remained close to the blood vessels, whereas lower-affinity antibodies were able to diffuse deeper into the interior of the tumor. To compare the tumor pharmacokinetics of the antibodies, the team utilized two radiolabels, I and In.
"The first isotope gives a snapshot of intact antibody in the tumor cells," continued Dr. Adams. "The second gives a historical record of how much antibody was taken up over time. It was evident that high-affinity antibodies were internalized and degraded by tumor cells at a higher rate than low-affinity antibodies." Inverse correlation of efficient tumor penetration with the antibody binding affinity has a tangible impact on the exposure of the tumor to the drug. Utilization of these principles allows for rational design of antibody therapeutics.
"Treatment of small tumors or delivery of cytotoxic payload may be more effective with high-affinity therapeutics. Low-affinity drugs may be used for large tumors or when it is critical to bypass the same target present on the normal tissues," added Dr. Adams. "We utilized these principles to create a Her3/Her2 bispecific antibody. One low-affinity arm blocks the ligand-binding activity of Her3, the other arm has moderate affinity to Her2 and facilitates effective tumor targeting. The dual approach ensures deeper penetration combined with increased targeting selectivity."
Merrimack Pharmaceuticals licensed the work and further improved on Dr. Adams' prototype antibody, creating MM-111, a highly optimized bispecific antibody fusion protein. The two arms of the antibody are linked by a modified serum albumin.
The company initiated a Phase I of MM-111 in breast cancer patients overexpressing the Her2 receptor. The study is enrolling patients whose cancer progressed on Herceptin or other standard therapy. The efficacy goal of the study is to evaluate progression-free survival in the enrolled patients.
The ability to predict the metabolism of new drugs in humans at early stages is critical for drug development, especially in light of FDA guidance issued at the end of 2008. The Guidance for Industry: For Safety Testing of Metabolites (or MIST) requires that metabolites present in greater than 10% of total drug-related systemic exposure require additional safety testing, in case they are present disproportionately in humans as compared to study animals.
"Cultures of human hepatocytes and liver preparations are two common systems for evaluation of drug metabolites," commented Gerhard Gross, Ph.D., head of drug metabolism at Lundbeck. "However, these systems are stationary. By using these systems we cannot adequately predict the extent of systemic exposure of drug metabolites."
Unfortunately, because of considerable differences in metabolic pathways between laboratory animals and humans, experiments with animals do not always correctly predict what happens in humans. Therefore, the recent development of a mouse with a human liver presents the best approach for studying human pharmacotoxicity.
One such model is a uPA+/+/SCID transgenic mouse. Livers of immunodeficient (SCID) mice are damaged by targeted expression of transgene (uPA, or urokinase-type plasminogen activator). When human liver cells are injected in these animals, the human cells colonize the mouse liver. The higher the replacement rates, the more predictable this model becomes for metabolism and toxicity studies. Careful examination of histology and pharmacokinetic parameters for chimeric mice supports their use as a model for evaluation of drug AME and also drug-induced hepatotoxicity.
Lundbeck's new investigational compound is primarily metabolized by the cytosolic enzyme aldehyde oxidase, which is preferably expressed in humans and monkeys, with significant species differences in metabolism across other species. Therefore, obtaining an accurate human PK prediction was a challenge. Testing this compound in the chimeric mouse demonstrated a significantly higher clearance rate, indicating that the model may indeed be useful for accurate human PK predictions.
Lundbeck is continuing investigations with additional compounds that showed disproportionate metabolites in humans. "The logical application of this model is in studies of human pharmacokinetics/metabolism and also human-specific toxicities. However, the model can also potentially be used for ranking compounds, specifically oncology drugs, regarding maximum tolerated doses," according to Dr. Gross.
"Chimeric mice carrying human livers have wide applications in both preclinical and clinical areas," commented Elizabeth Wilson, senior scientist at Yecuris. "With tremendous shortages of healthy livers, human organs grown in laboratory animals may become a viable source for transplantation. Liver cells from a patient can be used to repopulate a scaffold of animal livers, resulting in an autologous organ."
At present, Yecuris strategically focuses on preclinical applications, developing hepatocytes for drug discovery, toxicology, and metabolism studies. Yecuris technology uniquely enables controlled replacement of mouse hepatocytes. The mice lack fumarylacetoacetate hydrolase (Fah), a critical enzyme that in normal animals breaks down the byproduct of tyrosine catabolism. In the absence of the enzyme, fumarylacetoacetate accumulates in hepatocytes, causing cell death.
Yecuris mice survive when the production of fumarylacetoacetate is blocked upstream by Nitisinone, an approved clinical drug. Once the protective drug is withdrawn, the toxic buildup slowly and selectively damages mouse liver cells. The mice lack T, B, and NK cells, facilitating engraftment of human cells. Mouse cells undergo gradual injury over several induction cycles, which provides time for even slowly dividing human adult hepatocytes to expand sufficiently to sustain liver function. Therefore, cells from any donor of any age can be used for repopulation. Moreover, the ratio between human and mouse cells can be fine-tuned to support a variety of applications.
Recently, Yecuris improved upon the initial model to include simultaneous engraftment of liver and immune systems, which represents a significantly improved tool for toxicological studies. "While high replacement levels are required for drug metabolism studies, comparative toxicology studies may need a 50/50 ratio between mouse and human cells," continued Wilson.
A Pfizer PPARa agonist Wy-14,16443 was tested in the Yecuris model, comparing its effect on mouse and human hepatocytes in the same treated animal. Consistent with the conventional assessments, the treatment resulted in different histological profiles, gene-expression, and proliferation rates between mouse and human cells. A marked increase in hypertrophy and increased proliferation was observed in mouse cells but not in the nearby human cells.
"For such studies, it is desirable to have a mixed ratio of mouse to human cells to provide elucidation and controls of species-specific toxicity. Also, in certain infectious disease applications, it is also beneficial to have fine control over a mixed cell population to avoid death in the host species," said John Bial, CEO. Recently Yecuris engineered FAH knockout mutations into rats and pigs and has future plans to address new organ systems.
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Source: The Verge
quote: I always considered having Google Maps, Google Search and YouTube built into iOS a major advantage that Apple had over their competitors
quote: It is a HUGE advantage over Windows Mobile/Phone 7, Blackberry, Symbian, et al. Android has those apps built in of course, but Apple wants to compete with Android, not Blackberry and Windows.
quote: You may be able to re-add some of these things, but how anti-competitive can you be when removing a competitors product that all your customers want from a shipping product?
quote: If Apple users knew how to install 3rd-party applications, they wouldn't be Apple users.


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First-Sunday-of-the-Month Brunch: March
Join us for what is sure to become a family tradition: Brunch at the Museum Café on the first Sunday of every month!
Eggs any style, omelets, French toast, and waffles cooked to order; fine pastries, fruit, juices, coffees, and tea. View the brunch menu.
Reservations recommended, call 202-628-1068. $25 per person.
Receive a 10% discount in the museum shop by presenting your receipt from brunch. Discount only available the day of your brunch. Cannot be combined with any other discounts.
The first Sunday of the month is also Community Day—enjoy free admission to the museum all day!


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HOME NFL New York Giants Gear New York Giants Kids New York Giants Kids Preschool & Toddler (74 items) Product ID: 1778130
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Systemwide Events Calendar
The Wellness Center - Fitness Class ScheduleNovember 27, 7:30am - 7:30pm
Maui Campus, Pilina Bldg., Wellness Center
7:30am-8:30am – R.I.P.P.E.D. w/Kelly W.
11:00am-12:00pm – Core Training w/Brian
1:30pm-2:30pm – Yoga w/Rachael
3:30pm-4:30pm – Muay Thai w/Brian*
4:30pm-5:30pm – Boot Camp w/Brian
5:30pm-6:30pm – Zumba w/Jacky
6:30pm-7:30pm – Aerobics Fit w/Brian
*Shin guards, mouth piece, hand wraps and gloves are required.
____________________________________________________________ How Much Does Membership Cost?
* Students: $35
* Faculty / Staff: $55
* Seniors (55 +): $55
* Community: $70
Take all the classes you want for one low price!
Membership is good for one whole semester!
Event Sponsor
Student Life, Maui Campus
More Information
808-984-3434, http://uhmcwellness.wordpress.com/, Wellness Center Application PDF (PDF)
|Wednesday, November 27
|Wednesdayʻs with WenDee at the Womenʻs Center
Manoa Campus, QLC #412
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Strategies for Taking Notes
Maui Campus, The Learning Center
|German Film Series - Fall 2013
Manoa Campus, Moore Hall 258
|Meteorology Seminar
Manoa Campus, Marine Sciences Building, MSB 100
|Gift of Poetry Workshop
Manoa Campus, Kuykendall 410
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- The Wonder of Learning: the Hundred Languages of Children Exhibit
- Red Hat System Administration I
- EWC Arts Exhibition: Bollywood & Beyond: Costume in Indian Film
- Kalaupapa -- A Source of Light, Constant and Never-Fading
- Trip Around the Island
- Convergence: Glitch_Click_Thunk, Featuring Mark Amerika
- Trip Around the Island exhibit
- Waikiki Parc Features Ashley Huang
- Holding On, Letting Go
- Mark Amerika's image-Exchange for Convergence
- UHWO Bookstore Xmas Sale


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Now used as a nickname for Atlanta. Origianlly used as a nickname for the Federal Penitentiary in Atlanta which used to be the maximum security penitentiary in the country and is where famous mafia gangsters such as Al Capone were locked up. Located at the end of Boulevard in Atalanta in one of the more dangerous neighborhoods. Also called simply "the pen" by locals.
What happened to Mike?
He got locked up in the A
Big Boi: If you want me you can find me in the A - Atlanta reference
He got locked up in the A
Big Boi: If you want me you can find me in the A - Atlanta reference
por G-Loe 01 de Novembro de 2006
Trending Now
Can you define these popular missing words?
Top Definition
The coolest most sexy funny smart badass dudette in the universe
Oh man, that girl is such a Thea, way outta my league.
por Ishkabibble 20 de Agosto de 2003
the worlds most sexy and lovable person. she has all the qualities you want from a girl, the first is she is gorgeous, and the others i don't recall...yes and she's all mine.
-pule? jeg kan være kamelen denne gangen...
por towanda 03 de Janeiro de 2004
Thea is the sweetest girl on the planet - amazing, nice, friendly, transfer student from Norway, a good friend, and gorgeous too! Her name means adorable.
person 1: "Did you see Thea today? She looked adorable, as usual!"
person 2: "Yeah, and everyone's gonna really miss her when she goes back to Norway"
person 1: "Yep, I wish she could stay!"
person 2: "Yeah, and everyone's gonna really miss her when she goes back to Norway"
person 1: "Yep, I wish she could stay!"
por ds2runner 25 de Maio de 2010
pritty; friendly; awsome; cool;bestest frind i know
Thea Amundson is The coolest most awsomest girl ever
por Rachel Davison 17 de Dezembro de 2003
shares the same root as thealogy the study of goddessess. This is because thea is synonymous with grace, beauty, intelligence and being downright sexy, all of which are traits of goddesses.
Hey Thea, your so fine you blow my mind
por the admirer 27 de Setembro de 2006
I talkative, cute, creative chick. Really good at drawing painting or what ever creative is happening. Hangs out with awesome and different people and likes acting out different personalities. An Italian type of person.
Thea is a cute person who reads a lot of manga like Hetalia.
por Emo Kitty 26 de Maio de 2010
Thea is a name. A girl named Thea is amazing sexy hot everybody loves her for example because of her great body. A Thea has amazing tits and ass has a great sense of humour. She can be very shy when you meet her but if u get to know her just a little shes one of the most amazing person you'll ever meet. Thea is a great friend ho always supports her friends and if a Thea loves you you should never let her go, it's a lot of guys ho would want her so look after her but don't be to overprotective but Thea will love u unconditionally if u deserve it
Omg she's such a Thea!
por Ilikekorv 29 de Abril de 2015


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Discover Your Passions and Make a Difference in the World at USD!
In fewer than 60 years, the University of San Diego has grown from a local college with 50 students and a handful of professors to a nationally ranked university. This achievement is the direct result of a single, unwavering expectation: academic excellence.
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To hear the mothers of the sect tell it, life on the Yearning for Zion Ranch was close to idyllic. On a typical day at the polygamist compound in Eldorado, Texas, the kids couldn't wait to hop out of bed at 4 a.m. – "or at 3:30 if I let them," chuckles Rebecca, one of the mothers gathered out on the front porch of a dorm, who, like the others, declined to give her last name. Another mother, Sarah, says there was almost a daily competition among the kids to see who could get going earliest in the morning. "They don't like to be the last ones up," she says. Older girls were charged with getting two or three younger ones ready for the day, getting them dressed and making sure their hair was combed.
Just as the making of their Little House on the Prairie clothing – the high-neck dresses and sturdy blue shirts – was a labor of love, so too was meal preparation. Forget convenience foods. "It's not just 'Open this can,' it's 'Get out the wheat to grind,'" says Esther, who appeared to be in her 40s. "It's as precious as can be to make a meal that's nutritious and healthy for them." After the morning meal, the day was filled with school (the kids attend a sect school, but moms boast that first-graders can read on the fourth grade level), singing, piano lessons, gardening and chores. And virtually no one is exempt from chores. Little ones would help dry dishes from the morning meal and boys would cart the "bit bucket" of leftover food out to the compost pile or begin working the garden. Esther couldn't be more proud of the children. "They love to work," she says. "This is a regular, everyday thing: We love to learn." And by 7:30 p.m. the children are ready for bed. "I love it here," sums up Gloria. "And so do the children."
It is an unabashedly rosy view of life on the FLDS compound – and, according to the state of Texas, a grotesque distortion. Two weeks after authorities staged a massive raid on the YFZ Ranch that netted 416 children and 138 women, a far more disturbing image of what cult members don't reveal is coming into view. Combing through vaults, safes and computers at the Eldorado compound, a headquarters of the Mormon-offshoot Fundamentalist Church of Jesus Christ of Latter Day Saints, investigators apparently found evidence of abuse, including young teenage girls who had been sexually abused and were pregnant or had given birth. According to one report, authorities discovered a bed in the limestone temple of the cultlike organization where underage brides are believed to have been forced to consummate their marriages. So compelling is the evidence that state officials have said they will recommend to a judge scheduled to preside over a hearing April 17 that all 416 children be put into foster care to "prevent further abuse."
Life in the Cult
Matthew Mahon


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AmeriCorps VISTAs of Weld County is encouraging community members to donate to its Share the Warmth Clothing Drive to benefit the Greeley Transitional House and the Guadalupe Shelter.
The group asks for coats, scarves, gloves, hats, socks, underwear, and winter boots.
Research conducted by United Way of Weld County indicates that 2,500 Greeley residents struggle with housing instability. According to a news release, 188 items have been collected as of Wednesday.
"The recession has definitely made things more difficult," Rose Kinane, an AmeriCorps VISTA working with the Homeless Coalition, said in the release.
"Waiting lists for housing have grown a lot," Kinane said.
Donations are being collected at United Way, the Boy Scouts of America office, the School District 6 administration building and around the UNC and AIMs campuses through Jan. 21.
For more information, contact Lisa Monsen at (970) 353-4300 or email@example.com.


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Top Definition
door freakshow1414 31 augustus 2010
Trending Now
Can you define these popular missing words?
Shirley Q. Liquor's ignunt pronunciation of the word "homosexual".
"Where all these homosexicals is started comin' from? You know what I'm sayin'?"
"Hell, they got so many names fuh it, and then bulldygles, I'm sorry, lebeezuhns!..."
"Hell, they got so many names fuh it, and then bulldygles, I'm sorry, lebeezuhns!..."
door mindtch0101 27 mei 2009
refering to the reproductive gonads of a homosexual male
Matt: Hey randy was that ur homosexical
Randy: among other things
Randy: among other things
door *&% 24 april 2008
act of being homosexual
to act in a gay manner
to act in a gay manner
that homosexical was checking you out
Sick means im attractive
Sick means im attractive
door credious 19 november 2007
A syper gay, queer little boy
Wow Matt and Trevor are the biggest homosexicals.
door Funky Fred 25 juli 2008


text:
LEWISTOWN - Ethel M. Barger, 87, of 3533 Route 103 N., Lewistown, died at 4:05 p.m. Saturday, Dec. 8, 2012, at her residence.
Born Aug. 4, 1925, in Selinsgrove, she was a daughter of the late Rodger Bingaman and Elsie (Meiser) Bingaman.
She is survived by her husband, William (Gordon) Barger, whom she married on May 14, 1959.
She also is survived by: children, Dean B. Bigelow and wife, Diane, of Huntingdon, Peggy A. Hoffman and husband, William, of Huntingdon, Mark W. Barger and wife, Susan, of Petersburg, David L. Barger and wife, Mary, of Granville, and Elanie M. Beam and husband, Norman, of Petersburg; step-children, Jesse Barger and wife, Sharon, of Lewistown, Larry Barger and wife, Bunni, of Duncannon, and Beverly Bishop and husband, Michael, of Landisburg; brother, Stanley Bingaman and wife, Ruth, of Lewistown; sister, Elsie Black of Mission, Texas; and numerous grandchildren and great-grandchildren.
Ethel helped her husband as a photographer's assistant in Huntingdon.
She was Lutheran by faith.
Services will be private and at the convenience of the family with Pastor Fred E. Hickok officiating.
Interment will be in the Church Hill Cemetery, in Reedsville.
Memorial contributions can be made to the family to go toward funeral expenses.


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Wal-Mart's to hire 50,000 for holiday season
Wal-Mart Stores Inc. says it expects to hire more than 50,000 temporary employees this holiday season and will be offering more hours to its existing workers.
The world's largest retailer, based in Bentonville, Ark., says that this year's holiday hiring will be up slightly from last year, although it declined to give a precise figure for the increase. The discounter operates more than 4,000 stores in the U.S. and employs about 1.4 million people nationwide.
Wal-Mart's announcement Friday follows one by Kohl's earlier this week indicating its stores will be hiring more than 52,700 people, up more than 10 percent from last year.
Copyright 2012 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Professional's Choice® Sports Medicine Boots™ II
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Smith Brothers is proud to offer a 100% satisfaction guarantee on all of our products. We stand behind the quality of our products, and should you not be satisfied with your purchase, simply return it and we will refund, replace or exchange it for you.


text:
As the area's Christians prepare for the most sacred time of year, the area's faithful bow their heads and send their prayers skyward.
So, what are the region's religious leaders praying for this Easter?
Peter Vial, pastor for Davis Memorial Presbyterian Church, is praying for a deep sense of serenity.
Article Photos
Above: The Very Rev. Donald X. Higgs uses a thurible with incense Thursday during Holy Thursday services at St. Brendan Catholic Church in Elkins. Use of the incense recognizes the holiness of the altar and oil of Catechumens, oil of the Sick and the Holy Chrism. Smoke rising from the thurible symbolizes parishioners' prayers rising to heaven.
At left: From left, Bruce Butcher as Jesus, Leon Brown as Peter and Paul Gowers as Simon partake in communion during practice of the Good Friday services re-enactment at Mt. Carmel Baptist Church near Beverly.
"Certainly, (I'm praying for) peace and Americans coming together and moving forward as a nation on some of the important things we need to figure out - violence and strengthening families," Vial said on Good Friday. "I suppose I'm praying for the the opposite of tragedy. Over the past year, we've had financial tragedy, we've had blood-spilling tragedy.
"There's tragedy every day right here in Randolph County," he continued. "We're constantly called to work on strengthening a sense of peace in our nation as well as our local area. If you pick up the paper, it seems there's a story about a drug bust everyday. That's symptomatic of something - that's symptomatic of an economic reality, that's symptomatic of family issues, all of which can be connected."
Fr. Ron Nikodem, priest at Holy Rosary Catholic Church in Buckhannon, says he will also be praying for peace - as well as for the three people, called catechumens, who plan to join the Catholic church on Easter Sunday.
"Of course, we'll be praying for the poor and the downhearted... for world peace, and certainly we would be praying for the victims of the shooting in Newton, Conn. as well."
Jamie Estep, pastor for the Elkins Family Worship Center and the head of Randolph County Ministerial Association, is praying for the Christian church itself.
"The big thing with me is just praying for the Church in America today," Estep said. "I am a pastor that 100 percent believes in the Church, and I am excited to be a voice that gets to speak on behalf of the church. I see the church as the body of Christ that will rise up and be a central value of a city and of a family and of a community in these days in which we live," he added.
"We always pray for all of our brothers and sisters in the Christian church and the Christian faith," said Jess Felici, a pastor for the Mountain Lutheran Parish, which is comprised of five churches in Pendleton and Pocahontas counties.
"But tonight, on Good Friday, we're going to pray the Bidding Prayer, and the Bidding Prayer sets us up for Easter because we pray for the Jewish people and people don't share our faith in Jesus Christ and the whole of creation, as well as all of the people in public office."
According to his Twitter account, the prayer of the newly anointed Catholic pontiff, Frances I, is that people all across the world "enter more and more into God's logic of love and self-giving" this Holy Week.
"Being with Jesus demands that we go out from ourselves, and from living a tired and habitual faith," the Pope wrote Wednesday.


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Brian Beckman: Project Quark - A New Beginning for Quantum Computing Rises from the Ashes of Theoret
- Posted: Apr 01, 2008 at 10:58AM
- 35 comments
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Software Architect and Astrophysicist Brian Beckman has a new job at Microsoft. No longer working with Erik Meijer on cutting edge developer tools and programming languages, Brian has joined a very small team of distinguished engineers and technical fellows
that seeks to create a new product for Microsoft, code named Quark.
Brian and his big brained colleagues have produced a prototype quantum computing device that takes the notion of parallel computation to a whole new level... The really interesting thing here is that Brian has determined that theoretical phyiscs has completed. What does that mean, you ask? Well, only Dr. Beckman can explain it in terms that everybody will be able to comprehend.
Tune in. This is very big news. Computing will never be the same thanks to Brian and his colleagues working in the newly formed (and apt-named!) Quantum Unreality Computation Group.
Low res file here.
Oops, something didn't work.
Oh, what a masterfully woven frock of deception -- you guys had this emperor wearing it all the way down town!
Lead through the sublime history of physics from Newton to Einstein to some guy named Garrett Lisi (who could be the next Einstein) -- even blending in Rubic's cube and the monoids for added texture -- then over the edge of absurdity. Before I could realise what was happening I was being told to look down -- while you switched the gravity back on!
I always suspected you guys at Microsoft were evil geniuses, but this proves it! I'm coming up with a plan to get you for this, just as soon as I stop laughing.
Happy April 1 to you too,
Yeah, the 30 minutes was an achievement, but I must admit this stretched my April Fool's good humour to the limit, 30 minutes of listening to the WMA and then it is an April Fool's. Funny, which is why I didn't do the first post warning others it was an April Fool's, but just a little too long and too much time wasted for comfort...
a very entertaining video, good job
Nice, funny and very interesting joke, even inspirational.
Other guy with less credibility than Brian wouldn't make the same effect.
KevinB wrote:
Yeah, the 30 minutes was an achievement, but I must admit this stretched my April Fool's good humour to the limit, 30 minutes of listening to the WMA and then it is an April Fool's. Funny, which is why I didn't do the first post warning others it was an April Fool's, but just a little too long and too much time wasted for comfort...
"Quantum UNREALITY Computing Group" is an eentzy clue too It's all Charles' fault /wink /wink /wink
Interesting a lot of what you said is actually not so crazy!
For example some string theorists think that E11 might be the Lie group which is the symmetry of M-Theory. Now E11 is an infinite dimensional Lie group which it has to be in order to express all the infinite number of modes that can occur on a string or membrane.
A Lie group is expressed by its generators which form a Lie algebra, an element of which can be written L(n). Now an infinite Lie group is expressed in terms of a Kac-Moody algebra in which the index n can be any integer from minus infinity to infinity.
Each state of a Turing machine can be encoded as an integer by a particular coding system. For example taking the commutor of L(0) with L(n) should give the next state of the Turing machine L(n'). So we can ask, is there a Kac-Moody algebra that encodes the Universal turing machine? If so this would mean that Kac-Moody algebras are unclassifiable which would be an important question in physics.
Thus combining the ideas of computability, physics and group theory is not so outlandish after all! You would probably even get it published in a respectable journal.
(But I would leave out the part about the computers made of gloop!)
I watched this just after it was posted but i didn't want to comment and spoil it for everyone else.
Very well done
Pon wrote:So it's all a joke? Great. Thanks for wasting 500mb.
littleguru wrote:
Pon wrote:
So it's all a joke? Great. Thanks for wasting 500mb.
They call it April the 1st
Pon wrote:
littleguru wrote:
Pon wrote:
So it's all a joke? Great. Thanks for wasting 500mb.
They call it April the 1st
April the 1st is 5mb, not 500.
paulcoder wrote:
Thus combining the ideas of computability, physics and group theory is not so outlandish after all! You would probably even get it published in a respectable journal.
"It therefore follows that either one of the following is true:
deltalmg911 wrote:I not sure if that is correct.
Incomputability does not equal non-existence. Example the concept of pi. We now it exists though we can't compute it.
deltalmg911 wrote:
Similarly we can know that a particle exists somewhere and has a certain probability of being on some region without knowing for sure if it is there or not: that is the definition of probabilistic not deterministic theories. We can claim that quantum mechanics is right because the resulting probablities match what experiment shows the distribution to be, without necessitating that we can but an exact velocity and position vector on each particle in the universe.
Commercial application areas of quantum computing sustain radical development focuses from long term business investment upon computer science. Followings got reportedly investor's research relations in subjects of quantum application development, and it's not all about modernized computing and Microsoft platforms.
Quantum computing would have to be new area unlike traditional computing category of software and hardware, since it means more business controls than today's electric devices. For example, flying birds may supply less moving energy and scale independent real-time characteristic communication with databases in broader satellite stations to analyze weather and warming conditions. For advancing medical computing areas, sensor equipments might be replaced by the smallest scale of quantum computing controls. Not all of mobility systems carry sets of human interfaces, but consumer segment may see what Windows Mobile enables as total solution. Do investors yet feel bid to future ICT centric economics in references to future mobility systems and more applications? Try to meet Microsoft quantum computing making differences, not tons of computer physics.
That was, without a doubt the most meanest and fantastic Aprils Fools EVER!
Interesting start to the video of course. Only someone with the credibility of Brian could have pulled that off, lol.
USB Quantum Goo Machine
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It's that time of year again! Do you decorate your house with hundreds of holiday lights? If so, we want to see photos of your festive decorations on u local!
Upload your photos and videos to the Calendar Holidays, Holiday, Holiday Decorations category to appear in the slideshow above. Please include a brief description, along with the location of where the photo or video was taken.
Celebrate the holidays and start sharing today! Not a member? Click here to join u local, it's quick and easy.
Also, if you know of a holiday lights display at a home around town that catches your eye? We want to know about it! Please email firstname.lastname@example.com.


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Defrag Tools: #25 - WinDbg - Events
- Posted: Jan 28, 2013 at 9:57AM
- 2 comments
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In this episode of Defrag Tools, Andrew Richards, Chad Beeder and Larry Larsen continue looking at the Debugging Tools for Windows (in particular WinDbg). WinDbg is a debugger that supports user mode debugging of a process, or kernel mode debugging of a computer.
This installment goes over the commands used to diagnose an Event hang in a user mode application. We talk about single and multiple event hangs, automatic and manual events, waitable object handles and common design patterns that you will encounter. We use these commands:
Make sure you watch Defrag Tools Episode #1 and Defrag Tools Episode #23 for instructions on how to get the Debugging Tools for Windows and how to set the required environment variables for symbol and source code resolution.
Synchronization Functions
Sysinternals WinObj
[00:00] - Event objects
[03:56] - Waitable objects and Design Patterns
[08:00] - Handles
[10:52] - x64/x86/ARM calling conventions and 32/64bit addressing
[14:10] - WaitForSingleObject with a single Auto-Reset Event
[14:55] - !handle
[16:02] - .dumpdebug -- MiniDumpWithHandleData
[16:36] - !handle <handle> <mask>
[19:48] - Sysinternals WinObj
[24:14] - WaitForMultipleObjects with multiple Thread Handles
[30:00] - Work and Quit Event Design Pattern
[33:45] - WaitForMultipleObjects with multiple Event Handles
[38:52] - Windows Explorer example
[44:50] - Process Explorer also shows Handles (Ctrl-H)
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Excellent video. The content really reiterates and compliment concepts in the new Windows internal books. Great stuff... what do I need 4 years of Univ for when I got you guys.
@dcrearer: LOL!
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