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5 Reasons 'The Walking Dead' Has to Get Better
The lanes on the left represent the show's fanbase about halfway through the second season.
But it doesn't have to be that way! A serious, ongoing series about the zombie apocalypse could be so amazing, and after the last two episodes, I'm almost positive that The Walking Dead is finally going to have to start being the show I'm waiting for. For reals this time. Any day now.
P ... please?
This should go without saying, but I'll say it anyway: I'm going to spoil everything, in every sense of the term, for everybody. I'm going to spoil the TV show, I'm going to spoil the books and I'm probably going to spoil your overall sunny outlook on life. So really, don't read any of this if you haven't finished the comics, or if you're not caught up on the show, or just ... at all. Don't read this. It's the only safe thing to do.
#5. No More Red Shirts
"OH GOD! NOT JIMMY!" -- Nobody, ever. Not even Jimmy.
It's taken two full seasons, but they've finally done it: The Walking Dead has run out of Red Shirts. The aftermath of the farm scene left both Patricia and Jimmy dead -- two characters I had to actually look up to see if they had names, because I kept referring to them as "the guy that doesn't matter" and "the blonde girl that's not the other blonde girl." Seriously, when that kid stoically died in the RV without uttering a single line, I was convinced that the writers had just sighed a collective "fuck it" and threw some poor intern in there to up the body count. But IMDB insists that Jimmy was a real thing in several real episodes, so I suppose we should all care that he heroically died from not locking the fucking door. I lock the door when guys with a bitchin' tan walk too close to my Subaru; I'm pretty sure that's like the first thing any thinking human being would do before willingly driving into the Million Zombie March.
But I digress: Yes, it's a stupid and petty cop-out on the part of the screenwriters to keep throwing out chum instead of messing with the "real" characters. But you guys: This is almost it! With Jimmy and Patricia dead, that's almost all of the zombie kibble gone! The only two disposable characters left now are Beth and Carol. And Carol, as obnoxious and pointless as she is, has at least shown up for most of the episodes: There will be some sort of emotional consequences if the zombie apocalypse's Miss Punctuality gets herself killed.
"You guys having an apocalypse? Can I come? I promise I'll be quiet; you won't even notice I'm there."
It's like this: Have you ever come home after a hard day at work, and the first thing you do is to gather up everything you could possibly need -- phone, laptop, remote, beer, Hot Pockets, Kleenex, bail cash -- and put it all by the couch, just so you won't have to get up for the next few hours? Well, that's what the writers of The Walking Dead did, right at the start of both seasons. They carefully collected and arranged their Red Shirts within easy reach, so that they could lazily punctuate a scene with a meaningless death whenever they needed it. Have to build some tension in a hurry? Throw a handful of nameless campsite folks to the zombie hordes. Just realized the fishing episode was mind-numbingly boring? Hurl one of the racist caricatures to the undead. Not sure how to write a compelling chase scene? Start whipping Hershel's anonymous family members at the undead like batteries at a riot cop. But now that's it: There's only one more disposable character left to burn before the writers have to get up and walk all the way to the fridge to get another.
And they do have a track record of laziness, so maybe they just won't bother.
#4. Shane Is Dead
"Hey, if y'all need to externalize every negative attribute of your personalities, I'll be in the shitter. Hit me up."
One of the most compelling aspects of The Walking Dead comic was watching Generic Good Guy Rick being slowly but completely ruined by a lawless world. He started off as a cliche small town sheriff, sure, but only because it was fun to explore exactly what it takes to break Andy Griffith's mind and make him eat the rest of Mayberry. The character had to begin as a featureless paragon of virtue so we could watch anarchy tear him down to a baser level, but it's not that way in the show: TV's The Walking Dead had Shane survive two full seasons, and that was a mistake. He was cast as the reckless bad boy antihero from the start, and as much as that archetype might ravenously devour the panties of zombie apocalypse fangirls everywhere, watching his descent from amoral to evil just wasn't compelling TV.
In adapting the comic, The Walking Dead writers decided to split the Rick character up into Good Guy Rick and Bad Guy Shane, and had them bounce off of each other, rather than having one single character wrestle with opposing moral concepts. But now Shane is dead. Do you see what they've done? They've accidentally written themselves into a corner, and now they have no choice but to make Rick actually grow as a character! They're going to be forced to continue Shane's antagonist role within Rick himself, rather than having him sit on Rick's shoulder in a little devil costume and whisper cartoonishly evil suggestions in his ear, like he has been.
"Rape 'em, Rick!" "Well I don't see how that gets us a new air filter for the Bron-" "YOU'RE WEAK, RICK! YOU CAN'T PROTECT US!"
#3. Dale Is Dead
"If we don't leave a note on that car we just scratched, we're no better than the walkers!"
Dale is dead, and that sucks: I love the character. I love his goofy hat, his presence and even the gross implied old man three-way with Andrea and Amy, if only because it confirms everything I've always secretly suspected about people who live in RVs. But that was Comic Dale. TV Dale, I'm sad to say, was just boring. He brought the show grinding to a halt every time he opened his mouth, and even if he made sense at the time, or served some higher moral purpose, the end result was always the same: poorly written lectures about vague morality. TV Dale was the perfect excuse for the writers to tell instead of show. But now he's gone, and hopefully with him went the pro-bandit sermons and voting sessions, making room for more actual fucking zombies in your show about zombies.
And if Shane was Rick's cartoon devil, then Dale was the fisherman's-hat-clad angel on Rick's opposite shoulder. He only ever espoused one-note, oblivious goodness and morality, in diametric opposition to Shane's flat amorality. Dale and Shane were Magic Markers coloring in the blank cardboard cutout that was Rick. With not one, but both of them gone, the entirety of Rick's conscience has to be internalized -- you know, like a normal human being and not a man-shaped glob of Protagonist Brand Mayonnaise. So while I know that it looks like they killed off two of the more interesting characters on the show, take heart in that it was all in the purpose of giving us one really great one later.
Besides, if the show still needs a moral center (it doesn't), Hershel's going to make a way better Dale anyway.
Pictured: The last scion of human morality, about to shoot you in the dang face.
He has that whole sexily-shaken-religious-background thing going for him, he loves bourbon almost as much as he loves quaint farm-folk anecdotes and he even comes prepackaged with an Infinite Shotgun.
Shit, I'd buy that action figure.


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A tattoo which is located on a womans lower back. The size of said tattoo is in direct correlation to the degree of sluttiness or looseness of the woman.
Yo, I thought I did not have chance to get in 'dem jeans 'till I saw that large tramp stamp on her back.
de alsdad-gb 20 décembre 2006
Tattoo an a woman's lower back.. is indicitive of slutty tendancies.
Also: Tramp tag
Also: Tramp tag
"Hit up the chick with the tramp stamp"
de Aquap 11 août 2005
lower back tattoo currently trendy with girls who do not realise it stems from porn stars wanting to show up a money shot.also called slut or slag stamps
jenna jamesons got a tramp stamp
de djofarrell 21 mai 2007
One sure way of pointing out a woman you don't want to date. The tramp stamp's sole purpose is to provide a type of ID or banner for everyone to see that indeed this woman is trashy and not the kind to bring home to meet the family. It's a term used to describe the tattoo on the lower back of a woman....usually just above the butt crack.
"Man, I really liked that girl until I saw she had a tramp stamp! Everyone knows what kind of a woman puts something like that on her back."
de Three B 27 janvier 2009
A tattoo on the lower back of a female. Presence and size is directly proportional to 1) her sluttiness 2) whether or not she will swallow on the first date 3) whether she will give a male cock-rot and 4) whether or she has appeared in a gonzo-porn film will or will appear in gonzo-porn film.
Look at the size of that tramp stamp! I bet she swallows on the first date! I wouldn't go near her, though! I'd get cock-rot! With a tramp stamp like that, she must be a fluffer on a porn set!
de EmDubyaDee 16 décembre 2007
A tattoo strategically placed on a promiscuous woman's lower back, just above the buttocks. Usually a tribal design, a butterfly, or her name, just in case you forget when you are banging her doggy-style.
"Half the girls nowadays have tramp stamps. That must tell you something..."
de maryjanecartel 29 mars 2006
The tattoo a girl gets on her lower back, Indication that she is a dirty tramp. She wouldn't get it there if she didn't want people to check her out.
She bent over showing off her tramp stamp
de Yuly 11 août 2005

subset: commoncrawl


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Digital can no longer be a "carbuncle on the side of a company" says Content Strategist and Information Architect Karen McGrane. In the past 20 years she has been instrumental in transitioning major U.S. publishers' content from print to digital. She has worked with Hearst, The Atlantic, Fast Company and Time Inc., referring to publishers as canaries in the content coal mine. MSP-C Content King Juliet Stott interviewed McGrane about the importance of adaptive content and what big business can learn from the publishers who've been forced to go digital.
Companies embarking on content marketing have to have goals and objectives first and foremost, according to Rebecca Lieb, Altimeter Group's digital advertising and media analyst. Lieb, who also serves as a strategic adviser on digital marketing innovation to organizations ranging from start-ups to non-profits to Fortune 100 brands and regulated industries, believes asking questions and knowing your audience are the keys to setting these goals. MSP-C caught up with Lieb to learn more and to find out which companies she thinks are getting it right.
If we want to treat our content as a business asset, we must be able to measure its business value. Just as we evaluate any business asset against a set of standards for quality and effectiveness, we can apply a similar process to content.
Content is a business asset. And like any other business asset, whether it be real estate, equipment, intellectual property or personnel, it has value. That value can depreciate over time if care is not taken to regularly inventory and audit content against current and future business objectives.
Tweets, Facebook postings, and other social media channels can put brands into a cycle of knee-jerk reactions that do not necessarily reflect their company values. So much of what passes for great social media is pointless and off-brand.
Social is so prevalent in our world today. We see it being used everywhere and in everything we do, from service appointments, to coupon offers, to brand purchases, to a blog or Facebook posting.
Recent studies from the Content Marketing Institute and Contently give us some insight into whether content marketing is an effective tool for engaging with consumers.
After my wife returned from a retreat, she recounted a workshop on identifying truth, and it got me thinking about the difference between fundamentals and truths. I further began to consider whether, as content creators, any truths can be found in what we do.
Why ad agencies, PR firms, digital content and social media providers can't do everything well
Despite recent predictions that print media is a dying industry, there's plenty of evidence that Chicken Little might be ringing that particular death knell. In fact, print remains a thriving tool in today's multifaceted marketing and communication landscape. Content King Juliet Stott recently sat down with MSP-C creative director and Delta Sky editor-in-chief Jayne Haugen Olson to discuss the thriving role of print magazines, the secret to Sky's success and why this channel remains a vital source of readership and engagement.
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Top Definition
A devastating medical condition specific to men that once it strikes leaves the victim incapacitated and incapable of doing anything.
No known cure but time.
No known cure but time.
You know, when you're like on the couch and it's like "Damn, I've got tingly dick. Well I'm not going anywhere now."
door MKH - Don't playa hate 3 oktober 2006
Trending Now
Can you define these popular missing words?


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Sources: Bradley "Chelsea" Manning, NBC TODAY Show
quote: Personally, hell will freeze before I pay for anyone's sex change operation.
quote: Treason against the United States shall consist only in levying war against them, or in adhering to their enemies, giving them aid and comfort.
quote: The real question is, why are the pilots of the AH64 in the video Manning leaked not being charged with murder of innocent journalists and children?


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on February 26, 2013 - 1:37 AM
May 30, 1931 – Feb. 24, 2013
Eugene G. Miller of Sanborn, an author and longtime professor of English and German, died Sunday in Our Lady of Peace Nursing Care Residence in Lewiston. He was 81.
Known as Gene, Mr. Miller was born in Madera, Pa. He attended high school and college classes taught by the Societas Verbi Divini, or Society of the Divine Word, a Catholic missionary order.
Mr. Miller served two years with the Army, stationed in Germany.
He earned a bachelor's degree from Niagara University in 1956 and a master's degree in education from the University at Buffalo in 1972. He began his career as a substitute teacher in the Niagara Wheatfield Central School District, before teaching German at Hobart College in Geneva and at UB.
He was a professor of English and German at Niagara County Community College for 24 years, retiring in 1993 as a professor emeritus.
He was fluent in German and Latin, and also spoke some Spanish, Italian and French.
Mr. Miller received two grants from the National Endowment for the Humanities to study German at Tufts University in Boston, Mass., and rhetoric at the University of California at Davis. He also wrote two books: "Writers and Philosophers: A Sourcebook of Philosophical Influence in Literature," which he co-authored with Edmund J. Thomas, and "Essays on German, American and English Literature."
In retirement, he kept up with daily reading and writing, and his love of the arts.
Music was another interest; he told a Buffalo News reporter in a 2008 interview that if there had been a program in music when he attended Niagara University, that would have been his major. A fan of jazz, he had played the harmonica since high school. He also played the saxophone. In his later years, he took up the guitar.
Survivors include his wife of 52 years, the former Roseanne Beningo; three sons, Scott E., Brett E. and Curt E.; a brother, Joseph; and a sister, Suzanne Treichler.
A Mass of Christian Burial will be offered at 10 a.m. Thursday in Immaculate Conception Catholic Church, 4671 Townline Road, Ransomville.


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on November 3, 2012 - 2:29 PM
, updated November 3, 2012 at 8:18 PM
An unidentified man drove up to the crest of the Buffalo Skyway shortly before 2 p.m. Saturday, got out of his car and jumped into the water below in an apparent suicide.
Buffalo Police and Coast Guard officers scrambled to find he victim, described only as a white male in his 20s, whose body was recovered from the City Ship Canal near RCR Yacht Club. Homicide detectives, who were summoned to the Coast Guard Station, said a suicide note was found in the car.


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Past and upcoming scientific meetings sponsored or hosted by NIDDK
Enlaces a nuestra información en español
Diabetes, digestive, kidney diseases, obesity, weight and more
Health tips from Dr. Griffin Rodgers, Director of the NIDDK
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Overview of NIDDK activities in each major research area, including research advances, research coordination, and health information
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Sep 21, 2016
NIH awards more than $150 million for research on environmental influences on child health
The National Institutes of Health today announced $157 million in awards in fiscal year 2016 to launch a seven-year initiative called Environmental influences on Child Health Outcomes (ECHO).
Sep 19, 2016
Depression in early pregnancy linked to gestational diabetes, NIH study finds
Researchers at the National Institutes of Health have discovered a two-way link between depression and gestational diabetes.
Sep 16, 2016
HHS takes steps to provide more information about clinical trials to the public
In an effort to make information about clinical trials widely available to the public, the U.S. Department of Health and Human Services today issued a final rule that specifies requirements for registering certain clinical trials and submitting summary results information to ClinicalTrials.gov.
NIDDK's Health Information News
NIDDK's Health Information News is an e-newsletter that provides subscribers with information from all of the NIDDK's health communications programs, including the National Diabetes Education Program; the National Kidney Disease Education Program; the Weight-control Information Network; the clearinghouses for diabetes, digestive diseases, and kidney and urologic diseases; and the information services for blood diseases and endocrine and metabolic diseases.
Jul 27, 2016
New medication shows promise against liver fibrosis in animal studies
A new drug developed by scientists at the National Institutes of Health limits the progression of liver fibrosis in mice, a hopeful advance against a condition for which there is no current treatment and that often leads to serious liver disease in people with chronic alcoholism and other common diseases.
Jul 11, 2016
Genetics of type 2 diabetes revealed in unprecedented detail
A comprehensive investigation of the underlying genetic architecture of type 2 diabetes has unveiled the most detailed look at the genetic differences that heighten a person's risk for disease development.
Jun 10, 2016
Revving up human red blood cell production
Tracking both the what and the when of the human diet
Understanding how Crohn's Disease treatments affect children's gut microbiome
Custom-made fat tissue that burns calories
Identification of exercise molecule that promotes physical endurance
Improved outcomes and survival following acute liver failure in recent years
Mining the genome for insights into kidney function and development
Moving stones with sound—new ultrasound technology repositions kidney stones in people
Pain expectations: altered brain responses in people with irritable bowel syndrome
Diabetes portal adds data, more powerful search tools
The AMP Type 2 Diabetes Knowledge Portal online library and discovery engine has greatly expanded data and search capabilities to accelerate the pace of scientific advancement.
Jun 9, 2016
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network: Yielding new insights into challenging urologic pain syndromes
Story of Discovery: Erythroferrone–new regulator of iron balance
Story of Discovery: Hepatitis C: from non-A, non-B hepatitis to a cure
Story of Discovery: SGLT2 inhibitors: harnessing the kidneys to help treat diabetes
NIDDK Central Repository News
Features information about newly available datasets and materials from NIDDK-funded studies.
Apr 18, 2016
Islet transplantation restores blood sugar awareness and control in type 1 diabetes
New clinical trial results show that transplantation of pancreatic islets — cell clusters that contain insulin-producing cells—prevents severe, potentially life-threatening drops in blood sugar in people with type 1 diabetes. Researchers found that the treatment was effective for people who experienced episodes of severe hypoglycemia — low blood sugar levels that can lead to seizures, loss of consciousness and death — despite receiving expert care.
Healthy diet may reduce high blood pressure risk after gestational diabetes, NIH study suggests
Sticking to a healthy diet in the years after pregnancy may reduce the risk of high blood pressure among women who had pregnancy-related (gestational) diabetes, according to a study by researchers at the National Institutes of Health and other institutions. The study was published in Hypertension.
Apr 5, 2016
Outcomes in adults with acute liver failure between 1998 and 2013: An observational cohort study.
[University of Texas; Medical University of South Carolina] Acute liver failure (ALF) is a rare syndrome of severe, rapid-onset hepatic dysfunction without prior advanced liver disease that is associated with high morbidity and mortality. Intensive care and liver transplantation provide support and rescue, respectively.
Apr 1, 2016
First in human clinical trial of ultrasonic propulsion of kidney stones.
[University of Washington; Indiana University] Ultrasonic propulsion is a new technology using focused ultrasound energy applied transcutaneously to reposition kidney stones. We report what are to our knowledge the findings from the first human investigational trial of ultrasonic propulsion toward the applications of expelling small stones and dislodging large obstructing stones.
Delving deep into the kidney with a novel imaging technique
Mar 29, 2016
Children with Cushing syndrome may have higher suicide risk
Children with Cushing syndrome may be at higher risk for suicide as well as for depression, anxiety and other mental health conditions long after their disease has been successfully treated, according to a study by researchers at the National Institutes of Health.
NIDDK Director's Update
Features updates on NIH and NIDDK activities, events, NIDDK-specific plans, and trans-NIH issues.
Mar 10, 2016
This National Kidney Month, help your children adopt healthy habits
During National Kidney Month — and World Kidney Day — the National Institutes of Health encourages you to think about how to protect your children's kidneys, for today and for a lifetime. While most children with kidney disease were born with urinary tract problems or inherited diseases that put them at risk, some develop kidney disease as they age due to growing problems of young people, such as type 2 diabetes and high blood pressure.
Mar 4, 2016
Nutrition Roadmap Aims to Advance Research to Provide More Individualized Advice
WASHINGTON, March 4, 2016 – Today, the Interagency Committee on Human Nutrition Research (ICHNR) released the first Nutrition Research Roadmap designed to guide federal nutrition research. The 2016-2021 National Nutrition Research Roadmap encourages an increased focus on research that can lead to more individualized advice for promoting health and preventing disease.
Mar 3, 2016
Special Diabetes Program meeting summary highlights type 1 diabetes research NIDDK could support
Mar 1, 2016
Christopher J. Lynch to direct Office of Nutrition Research
Christopher J. Lynch, Ph.D., has been named the new director of the Office of Nutrition Research (ONR) and chief of the Nutrition Research Branch within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial.
[Harvard Medical School] The safety and efficacy of continuous, multiday, automated glycaemic management has not been tested in outpatient studies of preadolescent children with type 1 diabetes. We aimed to compare the safety and efficacy of a bihormonal bionic pancreas versus conventional insulin pump therapy in this population of patients in an outpatient setting.
Feb 29, 2016
Eylea outperforms Avastin for diabetic macular edema with moderate or worse vision loss
A two-year clinical trial that compared three drugs for diabetic macular edema (DME) found that gains in vision were greater for participants receiving the drug Eylea (aflibercept) than for those receiving Avastin (bevacizumab), but only among participants starting treatment with 20/50 or worse vision.
Feb 25, 2016
Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition.
[Washington University] Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants.
Feb 19, 2016
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.
[Washington University] As we come to appreciate how our microbial communities (microbiota) assemble following birth, there is an opportunity to determine how this facet of our developmental biology relates to the healthy or impaired growth of infants and children. Childhood undernutrition is a devastating global health problem whose long-term sequelae, including stunting, neurodevelopmental abnormalities, and immune dysfunction, remain largely refractory to current therapeutic interventions.
Genetic mismatches linked to kidney transplant failure
Feb 17, 2016
Diabetes drug may prevent recurring strokes
Pioglitazone, a drug used for type 2 diabetes, may prevent recurrent stroke and heart attacks in people with insulin resistance but without diabetes.
Feb 15, 2016
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.
Nephron endowment is determined by the self-renewal and induction of a nephron progenitor pool established at the onset of kidney development. In the mouse, the related transcriptional regulators Six1 and Six2 play non-overlapping roles in nephron progenitors. Transient Six1 activity prefigures, and is essential for, active nephrogenesis.
Feb 12, 2016
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.
[University of Colorado] T cell–mediated destruction of insulin-producing β cells in the pancreas causes type 1 diabetes (T1D). CD4 T cell responses play a central role in β cell destruction, but the identity of the epitopes recognized by pathogenic CD4 T cells remains unknown.
Feb 9, 2016
Nonaqueous, mini-dose glucagon for treatment of mild hypoglycemia in adults with type 1 diabetes: a dose-seeking study.
[Baylor College of Medicine] To evaluate mini-dose glucagon in adults with type 1 diabetes using a stable, liquid, ready-to-use preparation. Research Design and Methods Twelve adults with type 1 diabetes receiving treatment with insulin pumps received subcutaneous doses of 75, 150, and 300 μg of nonaqueous glucagon.
Feb 1, 2016
Proton pump inhibitor use and the risk of chronic kidney disease.
[Johns Hopkins University; Yale University] Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD).
Jan 29, 2016
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
[University of Iowa] Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three species, CFTR secreted bicarbonate into airway surface liquid.
Jan 25, 2016
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice.
[Massachusetts Institute of Technology; Harvard University] The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in individuals with diabetes. Pancreas transplantation and the infusion of cadaveric islets are currently implemented clinically, but these approaches are limited by the adverse effects of immunosuppressive therapy over the lifetime of the recipient and the limited supply of donor tissue.
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
[Massachusetts Institute of Technology] The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate.
Jan 21, 2016
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
[International Consortium of a large number of universities] Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals.
Jan 15, 2016
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
[Harvard Medical School] Genes encoding human β-type globin undergo a developmental switch from embryonic to fetal to adult-type expression. Mutations in the adult form cause inherited hemoglobinopathies or globin disorders, including sickle cell disease and thalassemia.
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.
[Columbia University; California Institute of Technology] Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly understood.
Jan 14, 2016
Weight loss and health status 3 years after bariatric surgery in adolescents.
[University of Cincinnati; University of Pittsburgh; Baylor College of Medicine; University of Buffalo; University of Alabama] Severe obesity affects 4.4 million children and adolescents in the United States, and few effective treatments are available. Particular concern has centered on health problems among severely obese adolescents and possible treatment with bariatric surgery.
Jan 13, 2016
Diet-induced extinctions in the gut microbiota compound over generations.
[Stanford University; Harvard University] The gut is home to trillions of microorganisms that have fundamental roles in many aspects of human biology, including immune function and metabolism. The reduced diversity of the gut microbiota in Western populations compared to that in populations living traditional lifestyles presents the question of which factors have driven microbiota change during modernization.
Phone: 1-800-860-8747 | TTY: 1-866-569-1162 | Email: firstname.lastname@example.com | Hours: 8:30 a.m. to 5 p.m. Eastern time, M-F


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Downtown residents will join Charleston County's "All-in-One" recycling in March, when 8,000 more homes are added to the program.
To learn more, visit recycle.charlestoncounty.org or call Carolyn Carusos at 720-7111.
"All-in-One," or single-stream, recycling allows residents to mix all of their recyclables in one 95-gallon covered roll cart, instead of separating them into separate bins.
Downtown business recyclingWhat: Cardboard recycling for some downtown businesses. County officials will notify businesses if they can be part of the program.When: The services begins Monday. Charleston County and the city of Charleston will collect cardboard for recycling from some downtown business five days a week. Businesses can put cardboard on the curb by 5:30 a.m. Monday through Friday for collection. King Street merchants should put out their cardboard by 9:30 a.m. All boxes must be flattened. For more information: call 724-7365.
The collection schedule also will change. Now, downtown residents' recycling is picked up on Thursdays. But starting March 18, the peninsula will be divided into six routes, and collection will done on different days.
In addition to homes on the peninsula, about 1,000 homes in I'On in Mount Pleasant will begin the single-stream program next month.
The county will begin delivering the roll carts March 11. People who are being added to the program will be notified by mail.
Recycling program manager Carolyn Carusos said the county recently purchased a smaller truck that will make picking up recyclables on narrow downtown and I'On streets easier.
The additional homes bring the number in the single-stream program to about 50,000, she said. The county collects recycling from about 110,000 residents. It regularly adds new neighborhoods, she said. "We're doing this inch-by-inch."
Data previously collected by the county showed that when new neighborhoods were added, the number of homes that participated increased by 67 percent, and the amount of material people brought to the curb every other week grew by 106 percent.
County Council Chairman Teddie Pryor said the county is looking for a site for a new facility to process the material because the current center on Romney Street simply isn't big enough for the increased volume. He expects county staffers and its solid waste consultant to make a recommendation by the end of March on where to build the new facility.
More new neighborhoods likely will be added to the program in early summer, Carusos said.


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on January 19, 2013 - 12:01 AM
Angels in America" is a play about everything that somehow feels like a play specifically about you.
Under the right circumstances, the six hours that make up its two parts will go by in a flash. Audiences lucky enough to have witnessed a keen interpretation of Tony Kushner's two-part masterpiece, which debuted on Broadway in 1993, have been known to stagger out of the theater in a state not unlike withdrawal, their eyes red from crying and their heads swimming with unanswerable questions.
The play's two parts, "Millennium Approaches" and "Perestroika," are now on stage in the Subversive Theatre Collective's Manny Fried Playhouse, in rotation through Feb. 16.
The play is an immensity, overstuffed with ideas and full of as much suffering, as much love – and as many well-placed jokes – as any American play. But it's also a deeply personal tale about a group of individuals seemingly as different from one another as it is possible for Americans to be, each one scraping and clawing his or her way toward a true identity.
In the first scenes, Kushner introduces us in stunning fashion to a character based on the motor-mouthed and much-hated conservative lawyer and eventual AIDS victim Roy Cohn, along with his entirely fictional young prot�g�, the buttoned-up Mormon law clerk Joe Pitt. In a scene that sets the strange magical tone of the play, we meet Pitt's emotionally unstable wife, Harper, in the midst of a Valium-induced hallucination.
And finally we meet two young men, longtime boyfriends Prior Walter and Louis Ironson (who through years of repeated readings, performances and viewings of Mike Nichols' extraordinary HBO film of the play, have come to seem more real to me than any other characters in literature).
As they sit at a bus stop in Manhattan, Prior, in his snarky way, reveals to his boyfriend the first of what will become many Kaposi's sarcoma lesions – a precursor to full-blown AIDS, which at the time was considered a death sentence. "I'm a lesionnaire. The Foreign Lesion. The American Lesion. Lesionanaire's disease," Prior says, not so subtly masking his pain in intentionally terrible puns.
That first crack in the foundation signals the coming seismic shift for the characters, who will be driven apart by Prior's illness and into the orbits of Joe Pitt, Roy Cohn, Harper and others. It also signals the trouble in their country, divided in the 1980s as it is today between equally powerful conservative and progressive urges.
After that terrible revelation, Kushner's play is off and running, surprising us at every turn as its characters discover what it means to be Mormon, what it means to be conservative or liberal, what it means to be gay and what it means to be American in the twilight of the 20th century. In the course of the play, which takes place largely in New York City, angels appear, heaven shakes and the dead speak.
The circumstances under which the Subversive Theatre Collective has mounted the play on the company's small stage in the cavernous Great Arrow Building on Elmwood Avenue are not ideal. In order to pull off the most ambitious theatrical gambit in its decadelong history, the company enlisted two directors, who in turn recruited two separate casts with the promise of adding even more dimensions to Kushner's already multidimensional characters.
The result is compelling in at least a dozen ways, largely because of actors like Jonathan Shuey and Greg Howze, whose work rises to the stratospheric challenges of the text. Those performances make it good enough for dedicated theater fans, and those who already know and love "Angels in America," to see at least once.
But in the ways that really count – the ways that rivet the eyes of new audience members to the stage, that crack open young minds and mint new theater lovers the way only great plays can, it falls short.
Great performances
First the good, of which there is plenty:
Both parts feature compelling performances of Roy Cohn, to whom Kushner has given the best speeches and many of the best jokes. In "Millennium Approaches," directed by Christopher Standart, Tim Joyce has all the frenetic energy you could hope to see in the character, and Jerrold Brown, in "Perestroika," directed by Christian Brandjes, has all the strange vulnerability of a man fighting to preserve his reputation even as he wastes away from AIDS.
Jonathan Shuey, in part one, brings the naivete of Joe Pitt – the confused Mormon, Republican lawyer – to stunning life in what is probably the finest performance in the show. Brian Zybala, his counterpart in "Perestroika," sustains the momentum ably. And Greg Howze, as Prior's friend and Cohn's nurse Belize, is the epitome of compassionate sass, ticking off one-liners with the skill of a great comedian. Likewise, Xavier Harris, the star of Road Less Traveled's popular "Insidious," keeps the ball rolling in "Perestroika."
In "Perestroika," Geoff Pictor brings Prior much closer to earth than his "Millennium Approaches" counterpart in a performance that is sure to become even better as the run progresses. Adam Yellen paints a three-dimensional picture of Louis, a wounded soul who continually dooms himself to unhappiness.
Much of the rest of the cast is capable if not transcendent, with inspired attempts from Kirstin Bentley and Megan Callahan as Harper, Gail Golden and Virginia Brannon as Hannah Pitt (Joe's mother) and, especially, Joy Scime and Darleen Pickering Hummert as the ghost of Ethel Rosenberg.
Setting the bar
Now, the bad:
In "Millennium Approaches," Prior (Brian Riggs) and Louis (Mike Votta) are deeply miscast. Riggs' supremely affected performance reminds audiences at every turn that he is acting. It therefore does not overcome, as a more naturalistic performance could, the fact that Riggs' age significantly exceeds that of his character.
Votta, who has been impressive in past appearances at Torn Space Theater and elsewhere, plays Louis as a strange variant on a Brooklyn mobster and misses the emotional fragility of the character almost entirely.
In both productions, the projection design by Seth Tyler Black constantly asserts itself at inappropriate times and places, as a stand-in for the audience's own imagination. This problem is most evident in "Millennium Approaches," when the beautiful writing of Harper's Act One hallucination must compete for the audience's attention with a theaterwide screen-saver.
The magical elements in both productions don't measure up to Kushner's vision for them, which he spelled out in the first pages of "Millennium Approaches." They should be, as Kushner wrote, "bits of wonderful theatrical illusion – which means it's OK if the wires show, and maybe it's good that they do, but the magic should at the same time be thoroughly amazing." The clip-art animated angel wings in this production don't do the trick.
Subversive's flawed "Angels," like too much theater in Buffalo, hamstrings itself by setting the bar inordinately high and then not allowing itself enough training to jump over it. This would be a moot point if we didn't know that Subversive and these two casts and directors were capable of better. But they are.
Even so, this major effort is worthy of sustained applause. It gives us a long-delayed look at a play that asks at least as many questions as it answers and confronts audiences with a dozen challenging moral propositions.
That same play also reaches so deeply into the flawed humanity of its characters that we feel like we have met them personally. For lifelong, incurable fans of "Angels in America" like myself, that will be much more than enough.
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LEETONIA- Photographs and stories about the village's history are being sought for a history booklet that will be used to help secure grants and raise funds for the Cherry Valley Beehive Coke Ovens restoration project.
Justin Hite, an Americorps VISTA volunteer interning with the village for a year, is developing a comprehensive and accurate history of the village and the Coke Ovens as part of the continuous project to improve the Coke Oven site. He said he is currently working on research and verifying stories, and is encouraging community members to share any stories or photographs.
Hite said he does not need to keep the original photos, explaining that they will be copied and then the owner will fill out a form granting permission for its use in publishing. Anyone with something to share can stop by Village Hall from 8 a.m. to 4 p.m. Monday through Friday or e-mail firstname.lastname@example.com.
According to Hite, the early history of the village was written in the early 20th century and is big and dense and not reader friendly. He said he hopes to make a more contemporary book that is easily accessible, a good resource for the majority of people in the community.
"We want a nice product, something people will want to read or might want to spend money on to help raise funds for the Coke Ovens," he said.
In addition to raising funds for the restoration project, the book will ultimately be used to assist in securing grant money, Hite explained.
"It should show the rich cultural history of the area," he said. "[Organizations] like to see a little bit about the area that would be getting the money."
The book is likely to be self-published by the village, depending on the final product, Hite said, noting that he hopes to have it completed before the end of February.
Hite arrived in Leetonia last month and is scheduled to remain until Nov. 18, 2013. His main objective is to secure grants to support the master plan presented in May by last year's intern, Marin Braco, which includes full and partial restoration of ovens, multiple ecological habitats and a variety of minerals for walking trails.
For information about the Coke Ovens project visit "Leetonia Beehive Coke Ovens" on Facebook or follow @LeetoniaOvens on Twitter.
Kevin Howell can be reached at firstname.lastname@example.com


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CIF State Football Championship Division IV Bowl Game- Solana Beach (Calif.) Santa Fe Christian vs. Modesto
(Calif.) Central Catholic at Home Depot Center at 4:00 p.m.
The state bowl games kickoff with a matchup of teams from the SacJoaquin Section and the San Diego Section. Santa Fe Christian is led by their quarterback-running back combo of Hunter Vacarro behind center and Tony Miro at running back. Meanwhile, Central Catholic is led by one of the top tight ends in the West, John Mundt, a commit to Oregon, who also plays on defense, and has been a huge part of the Raiders' success this season, on both sides of the ball.
CIF State Football Championship Division I Bowl Game- Long Beach (Calif.) Poly vs. Granite Bay (Calif.) at
Home Depot Center at 8:00 p.m.
Long Beach Poly, regarded as arguably the top talent producer in all of high school football over the past twenty years, is once again loaded with college level talent at several positions. The top overall prospect for the Jackrabbits is sophomore cornerback Iman Marshall. The elite 2015 corner has been stellar all season. Junior safety John Smith has great size, physicality and ball skills and has a handful of offers. UCLA linebacker commit Jayon Brown is another big-time prospect that plays with a lot of passion and attitude. On the offensive side of the ball, Washington State tailback commit Gerard Wicks is a tremendous power backs and is a great get for Mike Leach. Manusamoa Lu'uga also carries the ball for the Jackrabbits. Junior quarterback Eban Jackson took control of the Poly offense last week in their win over Clovis North. Granite Bay has rebounded from a 1-3 start and is playing in the state bowl game for the first time. They're led by Beau Hershberger, the linebacker who's been the anchor of their defense this season. Grant Caraway runs the Grizzlies offense and the two-headed running back duo of John Cooley and Tony Ellison has been a key to their streak, combining for over 2,700 yards.
Saturday: CIF State Football Championship Division III Bowl Game- San Diego (Calif.) Madison vs. Kentfield (Calif.) Marin Catholic at
Home Depot Center at 12:00 p.m.
Madison has a pair of Arizona commitments leading the way. Running back Pierre Cormier is one of the most explosive backs in the region and rushed for 1,976 yards and 26 touchdowns. Cormier committed to the Cats over Washington, UCLA and several others. Fellow UA commit Lee Walker is an explosive receiver and return man and caught 11 touchdowns this past season. Junior defensive back/receiver Michael Garner has already been offered by Arizona and could play on either side of the ball in college. Marin Catholic has one of the nation's top quarterbacks in Jared Goff. Goff had a strong showing at the Elite 11 QB Camp in the summer and had a big season throwing for 3,430 yards and 36 touchdowns.Offensive lineman Gunnar Graham is a Colorado commit and was the league lineman of the year. Junior receiver Andrew Celis is Goff's favorite target and is a talented cornerback as well. He caught 66 balls for 1,179 yards and nine touchdowns this past season.
Saturday: CIF State Football Championship Division II Bowl Game- Gardena (Calif.) Serra vs. Oakdale
(Calif.) at Home Depot Center at 4:00 p.m.
Serra is loaded with underclassmen including potentially the top prospect in the state next fall. Defensive back Adoree Jackson is an elite corner with huge upside. He could be the state's top corner right now and is one of the nation's top long jumpers as well. Junior linebacker Dwight Williams is an athlete who can run and hit and will have double digit scholarship offers by the end of the spring. Junior quarterback Jalen Greene is a dual threat quarterback who can hurt you with his arm or legs. Senior receiver Darrell Fuery caught 11 touchdowns and has good size and body control. Oakdale doesn't have a BCS prospect on their roster but has a pair of 1,000 yard rushers in Marcus Northcutt and Nikk Ryan. Quarterback Spencer Thomas has thrown for 1,671 yards and 25 touchdowns and Austin Jones is a deep threat who caught 48 balls for over 1,000 yards and 13 touchdowns.
Saturday: CIF State Football Championship Open Division Bowl Game- Corona (Calif.) Centennial vs. Concord (Calif.) De La Salle at
Home Depot Center at 8:00 p.m.
Centennial is known for their line play and they have one of the best tackles in the state in California commit Cameron Hunt. Hunt could play tackle or guard in college and has landed offers in the last week from Oregon, Michigan and Nebraska. On the other side of the line, DE Garrett Hughes has also committed to Cal and has had a very solid season. Junior QB Robert Webber may not have the size to play at the next level but he has dominated the competition this year. Webber has led the Huskies charge, but has gotten a lot of help from receivers Ryan Pascarella and Chase Krivashei, who both have come up with clutch catches in the last two weeks in game-sealing drives, against pretty vaunted secondaries. De La Salle is still the only school to appear in every state bowl game, making their seventh straight trip to Carson, and they're aiming for their fourth consecutive CIF State Open Division title. The state's top program features a loaded roster, headlined by U.S. Army All-American Michael Hutchings, a four-star outside linebacker who's committed to USC. He leads the Spartans' vaunted linebacker corps, that includes three-stars Victor Egu (Cal) and D.J. Moffitt. The Spartans were without Austin Hooper for part of the year, but the three star linebacker is back and healthy, and last week he had three sacks in their shellacking of Folsom. Also on the defensive line, Sumner Houston, a 2014 prospect, who's the younger brother of Wisconsin freshman quarterback Bart Houston, reminds many of former Spartan four-star and current Oregon State defensive lineman Dylan Wynn. Another 2014 prospect to remember is offensive lineman Larry Allen Jr., the son of former NFL All-Pro lineman Larry Allen.


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LOS ANGELES (AP) — George Clooney, Will Smith and Gwyneth Paltrow will join an impressive list of stars taking part in September's "Stand Up to Cancer" telethon airing on major networks.
Other celebrities announced Wednesday include Denzel Washington, Renee Zellweger, Kathy Bates and Richard Branson. Kareem Abdul-Jabbar, Lance Armstrong and Elizabeth Edwards were previously announced as participants.
Performers will include Green Day's Billie Joe Armstrong, Neil Diamond, The Edge, Herbie Hancock, Lady Antebellum and Leona Lewis.


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VANCOUVER - The pivotal Game 5 of the Stanley Cup Finals will start in just a few short hours.
With the series tied 2-2, will the Boston Bruins continue to seize the momentum and take a third win in a row, putting the Vancouver Canucks on the verge of elimination?
Or will the Vancouver Canucks continue the trend of the home team winning and set the stage for an elimination game in Boston on Monday?
Whoever wins tonight will have control of the series and the inside track at hoisting the Stanley Cup.
There are several questions and interesting storylines heading into tonight's game.
Will Tim Thomas continue his dominant performance and shut down the NHL's best offence?
Will Roberto Luongo get some support from his skaters, or will he be hung out to dry again?
In an emotional and all important game, will the officials be able to keep it under control, or will we see multiple players ejected with misconducts for the third straight game?
Throughout the day, I'll keep you updated with the latest storylines, news and analysis from Game 5 at Rogers Arena in Vancouver.


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Luca Bruno/Associated Press file photo
Luca Bruno/Associated Press file photo
SCHLADMING, Austria
Ted Ligety is one victory away from matching skiing royalty.
He�s already grabbed gold in the super-G and super-combined at the World Championships in Austria. So if Ligety wins today�s giant slalom � the event he�s dominated all season � the American will become the first man to win three or more gold medals at a World Championships since French great Jean-Claude Killy took home four golds in 1968.
�I did not expect to have two gold medals,� Ligety said. �I was hoping to get medals in the super-G and the combined, but I didn�t think they would be gold. So that�s definitely a pleasant surprise. But maybe that puts a little added pressure for the GS. We�ll see.�
Killy�s feat came on home snow in Grenoble in a year when the Winter Olympics doubled as the World Championships. He swept gold in all three Olympic events � giant slalom, slalom and downhill � and was awarded another worlds gold for combined.
The only other three men to accomplish the feat were Emile Allais, the first great French skier, who won three events at the 1937 worlds in Chamonix, France; Norwegian pioneer Stein Eriksen, who took home three golds from the 1954 worlds in Are, Sweden; and Toni Sailer, one of the first great Austrian skiers who won four golds at the 1956 Olympics in Cortina d�Ampezzo, Italy, which also doubled as worlds, and three at the 1958 worlds in Bad Gastein, Austria.
Ligety has won four of the five World Cup giant slaloms this season and also is the defending world champion in GS.
�Ligety is the perfect GS skier,� said Marcel Hirscher, the Austrian who leads the overall World Cup standings and the only skier to win a GS this season. �He has been everyone�s benchmark for five years now. I have tried to copy a lot from his style to get as close as possible to him.�
A victory by Ligety also would restore the U.S. to first place in the medals table. France moved ahead of the Americans when Tessa Worley won the women�s GS on Thursday for her country�s second gold and fourth medal overall.
But it was a memorable day for the Americans, too, as teenager Mikaela Shiffrin finished sixth in her worlds� debut. Shiffrin charged to fifth in the opening run with the No. 16 bib, then had another error-free trip down in the second leg. The only time she looked like a rookie came when she stopped to take a photo of the 30,000 fans in the finish area with her iPhone.
Besides the crowd, it felt like any other race for the 17-year-old Shiffrin.
�In the end it was just me and my skis and red and blue gates,� she said.
Shiffrin has won three slaloms this season to lead the discipline standings, but she never had finished higher than eighth in a GS. Next up for the high school senior is her main event, Saturday�s slalom, and Shiffrin indicated she wouldn�t be happy with sixth.
�Every race, whether I do poorly or I do well, I always want more,� she said. �So I�m going to be looking for a lot.�
Sponsored by Italian pasta maker Barilla, Shiffrin�s diet lately has consisted mainly of pasta and pizza. She eats pasta two days before races and pizza the night before.
�A couple weeks ago I was training three days in a row, and I had pizza each lunch the day before the training, and I had a lot of energy for the training, so I was like, �Pizza!�� Shiffrin said with a laugh. �I�ve heard that carb-loading the night before the race doesn�t really work, but (the pasta) was more like two nights before, so it was perfect timing. I planned that out.�
While the super-G course suited him, Hirscher stuck with his plan to skip the opening week of the championships. His first event was Monday�s team event, when he led Austria to gold.
�I have got my medal,� Hirscher said. �That doesn�t mean that I can go home now, but I am a little bit more relaxed. The pressure is lower.�
Still, skiing is the top sport in Austria, Hirscher currently is the sport�s biggest local star, and he�s competing on some of the slopes he grew up skiing on. Fans are hoping that he�ll sweep the technical events, and that he � not Ligety � ends up with three golds.
�I could do it, and I hope for it, but there is no master plan,� said Hirscher, who missed the 2011 worlds with a broken ankle. �I�m not a machine, and I�m not a Swiss watch.�


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Howie-in-the-Hills, Fla. – Stetson University freshman Dustin Dingus went into Sunday's final round of the Mission Inn Intercollegiate with a share of the 36-hole lead, but he was unable to earn his first collegiate victory, finishing fourth.
Dingus (Palm Harbor, Fla.) closed with a three-over par round of 75 to finish two shots behind Colin Brennan of Johnson & Wales. Brennan shot the low round of the tournament on Sunday, a three-under par 69, to move past Dingus and Appalachian State's Josh Nichols for the title.
Johnson & Wales teammate Chris Anderson and Bethune-Cookman's Ryan Fricker also moved past Dingus and Nichols to finish tied for second.
After storming to the lead with consecutive rounds of 299 on Friday and Saturday, Johnson & Wales (884) cruised to the team title with the low round of the tournament, 286, on Sunday. Bethune-Cookman (899) also finished strong with a final round score of 296, but the Wildcats were 15 shots behind J&W at the finish.
Host St. John's (904) finished third with Appalachian State (906) and Tampa (914) rounding out the top five. Stetson finished eighth in the 10-team field with a final score of 922.
Behind Dingus, the Hatters had freshman Andrew Peterson (Andover, Minn.) Finish tied for 21st after shooting a final round score of 75 to finish at 230. Junior Tyler White (Palm Harbor, Fla.) tied for 41st after bouncing back with a 75 on Sunday to finish at 236.
Sophomore Jose Rosales Cruz (Queretaro, Mexico) finished 46th at 247 after a final round score of 81. Sophomore Matt Taylor (Naples, Fla.) withdrew from the tournament following the second round.
The Hatters will continue a stretch of four tournaments in four weeks when they travel to Charleston, SC, this weekend to compete in the Wendy's Kiawah Island Classic, hosted by the Charleston Southern, at Turtle Point Golf Club.
Stetson will close the fall season on November 5-6 when the Hatters host the Stetson Invitational at Victoria Hills Golf Club in DeLand.


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on November 11, 2012 - 10:14 PM
, updated November 11, 2012 at 10:25 PM
FOXBOROUGH, Mass. – The toughest part, the thing that reaches in and rips out the heart of a long-suffering Bills fan, is that you knew it was coming.
Of course, you knew. It always ends this way in New England. It doesn't matter who is playing quarterback, or who is coaching the Bills, or who occupies the White House. Some way, somehow, the Bills will find a way to lose a game to the Patriots at Gillette Stadium.
You've seen it before. You suffered through the Holcomb sack, the McKelvin fumble, the Bledsoe and Losman meltdowns. So even as Ryan Fitzpatrick marched the Bills toward a potential go-ahead score, and a season-altering victory, you braced yourself for the worst.
That's what it means to be a Bills fan, right? When you've had your heart broken so many times, you learn to coat it in fatalism. You might be crying inside, but you laugh at the sheer inevitability of it all.
So you pack this one away, with all other ghastly memories. File it under "The Fitz Pick." The Bills played a courageous game, and they came oh so close, but they lost their 12th straight road game to the Pats, 37-31, when Devin McCourty picked off Fitz in the end zone with 23 seconds to play.
You know what's sad? The Bills didn't feel that way. They live in the present, and they really believed they were going to win and break the losing streak at Gillette. Fitzpatrick felt the momentum of the game and the season – and maybe his own embattled Buffalo career – about to change.
Then T.J. Graham ran a bad pass route, cutting behind McCourty instead of in front of him. And Fitz threw the ball right into the defender's arms.
"I'm really disappointed," Fitzpatrick said. "If we were able to win that game, all of a sudden, you turn the season around. You forget about the five losses before it and all that. It's a tough one to swallow for us, especially the way that it ended."
It could have been a glorious win, one that would have sent the Bills' spirits soaring and lifted them back into the playoff chase. If Fitz had gotten them into the end zone, it would have given him another comeback win over the Pats to go with last year's 34-31 victory in Orchard Park.
We all knows Fitz's shortcomings, but two wins over the Pats in two seasons would have been good for the resume. He played his heart out Sunday, completing 27-of-40 passes for 337 yards and two touchdowns. It was the best game any Bills quarterback has played in 12 years at Gillette.
Fitzpatrick completed a lot of the intermediate throws that come so difficult for him. He averaged 8.4 yards a throw against a Pats pass defense that specializes in giving up yards in chunks. He provided an emotional spark, getting in the face of Brandon Spikes after a late hit.
"Fitz is a competitive guy," said Bills center Eric Wood. "He takes that early shot on the sideline out of bounds [a roughness call on Alfonzo Dennard] and pops right up. He drew two personal fouls today and didn't sit down for a second."
For 59 minutes, Fitz outplayed the best of all time, Tom Brady. He had exactly 100 more yards than Brady. Much is made of Fitzpatrick's inability to stretch the field, for good reason. But Brady does much of his work underneath, too. Neither QB had a completion over 25 yards Sunday.
Brady is Brady, though. On a sub-par day, he doesn't make the mistakes that kill a team. He didn't throw an interception (although the Bills dropped two gifts). Fitz fumbled the ball away after an early sack, helping the Pats to a 10-0 lead. Then he was terrific, until the fateful finish.
He had a chance to silence his critics, at least for this week. After an injury to Fred Jackson – which cost the Bills a critical third timeout – Fitzpatrick hit Scott Chandler and C.J. Spiller for consecutive first downs, setting a team record for first downs in the process.
Fitzpatrick missed Chandler in the back of the end zone on first down. Then, with the clock winding down below 25 seconds, he threw the pass for Graham. The rookie admitted later that he should have cut in front of McCourty. It was too late.
You can question the wisdom of calling a play to a rookie receiver in that situation. Or you can wonder why they didn't get the ball in the hands of Spiller, their most explosive player.
In the end, the game was in Fitzpatrick's hands and he threw the interception, which most seasoned and skeptical Bills fans were secretly fearing – and expecting. Once again, he lived down to his reputation. Good guy, good leader, but just good enough to get you beat.
"I hate it for him," Gailey said. "He played so good, and to have that happen. … I've got to help him. I've got to make a couple better calls there at the end. If I do a little bit better job there, maybe he doesn't have to do that by himself."
There's plenty of blame to go around. Knock Fitz all you want, but this makes two games out of the last three where the offense put up 30-plus points and it wasn't good enough. What does it say about the defense when it allows 37 points and it seems like one of their better days?
Graham's poor pass route was one of many stupid plays by the Bills. They had 14 penalties for 148 yards, their most penalty yards in a game since the merger. A few of the calls were dubious, but when you commit that many penalties, you've had a far worse afternoon than the officials.
Gailey is right to take some of the heat. When a team commits six penalties in the first 12 minutes, it reflects badly on the preparation. He still isn't giving Spiller enough chances. Spiller touched the ball 13 times and had 131 yards from scrimmage.
Every week, Spiller finishes with stats that remind me of Thurman Thomas in Super Bowl XXV (imagine what he might have done if they were smart enough to use him more.) Spiller averaged 7.8 on nine carries. How long will he get more than seven yards a pop before they figure out it's a trend?
But the losses always fall at the feet of the quarterback. The Bills are 3-6 this season, 5-14 since Fitzpatrick signed the contract extension. As he said last week, the NFL is a performance-based business for quarterbacks.
"The only thing you can ask for as a quarterback is a chance at the end to win the game," Fitzpatrick said, "and we had that today. We did. We held them to a field goal at the end, and we drove down and had a couple of shots at the end zone. But we didn't get it done."
No, and in the bitter chronicle of Bills losses, that's all that matters. They're one loss, and one bad interception, closer to the next franchise quarterback.
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Cheer on your Philadelphia Eagles in this Backup Henley long sleeve T-shirt from '47 Brand! Arrive to the Philadelphia Eagles game in this tee and everyone will know exactly which team you think is best. This cool tee features three buttons at the top and bold Philadelphia Eagles graphics. Be sure to add this tee to your collection so you'll be ready to show your team spirit!
- 80% Cotton/20% Polyester
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- Three buttons at top
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- Brand: '47
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spanish creativity.
July for the month born and the "N" for the Puerto Rican fathers first name. There forth you get Julyn. And it isnt pronounced the way its spelt either theres another Spanish kicker for you. It pronounced JOO- LEEN
de the name barrer 03 Februarie 2010
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text: SHARE THIS FLOOR: Maison Versailles (27) Like Versailles Maple is a beautiful Northern maple that offers smooth graining with subtle hand worked edges and accentuation of the natural character. This majestic hardwood floor is sure to enrich any space. COLOR: Verandah SIZES: 7" x Random Length: 12" - 84" Add to Favorites Order a Sample PRODUCT DETAILS Product Number: MSV07VR1 Colorway Name: Verandah Sizes: 7" x Random Length: 12" - 84" Thickness: 9/16" Wood Species: Maple Edge Style: Full Bevel Color Variation: High Warranty: 50 Year Installation Type: Glue, Staple, Nail or Float FloorScore Certified: Yes Made In: Guatemala A square edge means boards fit flush against each other for a smooth, traditional look. A micro bevel or full bevel edge creates an angled effect where boards meet, to create more depth and dimension. Kissed edge is the same benefit of the micro-bevel, but with the look of a square edge. Rectified edge mimics the look of real cut stone. Optic edge creates the most realistic grout and bevels available on a laminate plank Variable edge recreates the rustic, hand-planned edges found in hardwood. Contoured edge has rounded edges for a soft and attractive visual. Tumbled edge features the natural, irregular edge flund in many types of stone. Hardwood – Color varies with each plank creating a natural mosaic. Low: Color varies slightly from plank to plank. Medium: Color varies moderately from plank to plank. High: Color varies significantly from plank to plank while retaining some similarity. Porcelain -Any variation in color or texture from tile to tile. Slight: Color and texture vary slightly from tile to tile. Moderate: Color and texture vary vary moderately from tile to tile. Substantial: Color and texture vary significantly from tile to tile while retaining some similarity. A FloorScore certification verifies that flooring and adhesive products have been tested and approved by the Resilient Floor Covering Institute (RFCI) in conjunction with Scientific Certification Systems (SCS) for contributing to good indoor air quality.


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October 17-21, 2016
Tuesday's Scavenger Hunt
Read "
Tuesday - "Learn About Solar Close-Ups
" page.
How far away from Earth is the Sun? ____________________
Where does all of the information about the sun come from?
With the best telescopes, what is the smallest an object can be for scientists to observe the object? ______________________
Click on
Observing the Sun
at the bottom of the page.
Read "Observing the Sun" and answer the questions below.
Name the two types of high energy radiation that the Sun's atmosphere emits.
________________________ and ________________________________
The two types of radiation mentioned above are used to view the Sun's __________________.
What blocks the high energy radiation from harming us on Earth?
If scientists want to study the high energy radiation, what do they have to do?
Once a telescope gathers data in space, how is the data transmitted back to Earth? ______________________
Three satellites are mentioned in this reading. Learn more about one of these satellites and write down two facts below.
Name of satellite: _______________________
Return to "
Tuesday - "Learn About Solar Close-Ups
" page.
Click on "
Example of a Solar Telescope in Space
" at the bottom and read the page.
What does TRACE stand for? ________________________
How many small squares make up a typical TRACE image? ______________________
What are each of the small squares called? ______________________
Once the EUV and UV light goes through the telescope, what records it? _______________________
What does SXT stand for? ________________________________
What images the SXT special? ____________________________________
Both TRACE and SXT images are made of ______________________ pixels, but SXT looks at the ________________ Sun while TRACE just looks at part of it.
Return to "
Tuesday - "Learn About Solar Close-Ups
" page.
Using your new knowledge about pixels as well as your knowledge of celebrities, you are ready to play today's game. Click on
Play the Game
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Adriano Gatto
Artist in Residence, Stage Combat and Recruitment
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Adriano has returned to Niagara University as the current Artist-in-Residence/Recruiter for the Department of Theatre & Fine Arts. Certified with Distinction by Fight Directors Canada and Recommended by the Society of American Fight Directors, Adriano's work as a fight choreographer has been seen at various theatres across the country, most recently the Irish Classical Theatre Co., Torn Space Theatre, Kavinoky Theatre and Road Less Traveled Productions. Adriano has taught stage combat and also choreographed for the Shakespeare Theatre Co., Indiana Repertory Theatre, and Geva Theatre, among others. Currently, he is a senior assistant to Fight Master Daniel Levinson at Rapier Wit in Toronto. As a member of AEA, Adriano was awarded an Acting Fellowship to train with Michael Kahn at the Shakespeare Theatre Company in Washington, D.C., winner of the 2012 Regional Theatre Tony Award. Professional acting credits include productions with Folger Shakespeare Theatre, Round House Theatre, Indiana Repertory Theatre, Walnut Street Theatre, MusicalFare, and Irish Classical Theatre Co., among others. Adriano was honored with two Artvoice Artie Nominations: Outstanding Actor in a Play for the world premier adaptation of Henrik Ibsen's Emperor and Galilean and Outstanding Supporting Actor in a Play for 33 Variations.


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Curve broadcaster Mike Passanisi probably delivered one of the best play-by-play calls in franchise history.
It wasn't even of something that happened on the field.
In a game on Sunday, a routine foul ball was hit into a suite box right next to the Curve Radio Network booth.
The foul ball landed directly into a cup holder. It didn't bounce off of anything. It didn't have a magnet inside of the ball or in the cup holder.
It landed directly into a first-row cup holder over a concrete barrier, and Passanisi called it all.
"I happened to be sitting there, and there was a ball, a foul ball," Passanisi, who is in his fourth season calling games for the Curve, said. "It just went into the cup holder. It was more of a shock factor if anything else. "
Luckily for fans listening in and others doubtful of the ball landing in the cup holder, there was a video of it.
That video went viral, appearing on several websites including popular sports blogs Deadspin, Bleacher Report and both Minor League and Major League Baseball's websites. As of 7:30 on Monday night, the video had more than 16,000 views on YouTube.
"Either way it's a great feat, I don't know, I think it's funny," Passanisi said. "I think it's something people are liking. I have friends in California who are like 'dude, you made Deadspin.'"
Passanisi let out a loud "Whoa" when he realized what he had seen. He also called the ball, fouled off by Erie's Brandon Douglas, "tremendous." All of this was said live on radio.
Curve staffer Justin Rhodes was able to capture it all on film.
"You see some strange foul balls, but nothing near something like that," broadcast partner Nate Bowen said. "I'm not even sure how it got in there."
Passanisi wanted to get a picture of it, but a fan in a neighboring suite simply walked up and pulled the ball out of the cup holder.
"I couldn't really see it but Mike's reaction let me know that something amazing had happened by his tone of voice," Bowen said. "I didn't know at first what that noise was, but once he said the ball landed in the cup, I think he said cup holder quite a few times. That clarified what had happened. "
Bowen said he has seen a ball land into a cup holder before, but never over the concrete wall at the suite level.
Passanisi said he had never seen anything like it before. He has seen some people catch foul balls in cups and popcorn buckets.
"It's literally one of those one-in-10,000 chances - maybe more - to have it land directly in a cup holder and rattle around," Passanisi said.


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fiestada is a schools version of mexican pizza. consisting of dough, mexican pizza sauce, cheddar cheese(say cheese!),mexican flavored sausage. can we say somebody wants to run south of the border? o'le!
hey miguel martinez aren't you excited for the fiestada's at lunch today?
od uživatele andy sauce 30. červenec 2007
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