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Citizen Surveillance Helps Officials Put Pieces Together
BOSTON—Living with Big Brother may have at least one benefit.
As surveillance technology has spread from security cameras to smartphones in every pocket, it has sparked privacy concerns. At the same time, the technology has proved helpful to criminal investigations—including the one focused on this week's Boston Marathon explosions.
On Wednesday, a government official said the Federal Bureau of Investigation used surveillance video from a Lord & Taylor department store and restaurants near the bomb site, as well as photographs from average citizens, news organizations and others to help identify a suspicious person at the marathon.
That followed officials earlier in the week asking the public to share digital video and photos, which the FBI processed along with surveillance-camera footage from businesses near the finish line. Investigators planned to go through "every frame of every video," Boston Police Commissioner Ed Davis said.
The use of such technology in the Boston investigations highlights how, since the Sept. 11, 2001, attacks, the adoption of surveillance technology and the amount of data gathered has grown considerably. Still, video and photo facial-recognition technologies remain in their infancy.
From 2011 to 2016, the global market for video-surveillance technology is expected to nearly double to $20.5 billion, according to IHS IMS Research. According to Forrester Research, 68% of public-sector and 59% of private-sector companies have adopted video-surveillance technologies—and 9% plan to adopt it in the next two years. Moreover, more than a billion people now carry a basic tool of surveillance in their pockets: camera-equipped smartphones that connect to the Internet.
Combining forensic image data from professional and personal sources has worked in previous cases. After the 2011 riots in Vancouver, British Columbia, authorities used nearly 1 million digital images and 1,600 hours of video gathered from the public and closed-circuit cameras to identify criminal acts and eventually bring charges against more than 200 people.
Challenges remain to making use of all the new data. Facial recognition is often difficult to use in large-scale investigations because surveillance footage rarely has full-frontal images, which are needed for computers to identify enough key points on a face.
Terror in the U.S.
Review other major plots of terrorism on American soil.
Site of the Blasts
"It's not the way it is in the movies," said Aki Peritz, a former counterterrorism analyst at the Central Intelligence Agency, now senior policy adviser for national security at Third Way, a Washington think tank. "In real life you don't have someone looking directly into the camera, and the ability to make a match can be very much degraded if you don't have a full frontal."
Then there is the challenge of collecting and sorting through the data. Boston has one of 77 nationwide intelligence "fusion centers" that is involved in helping investigators in this week's bombings to pool data and conduct analysis, said Mike Sena, director of the Northern California Regional Intelligence Center. The state-run centers were funded by the Department of Homeland Security after the Sept. 11 attacks to address the lack of interagency information sharing.
The centers allow authorities to tap thousands of law-enforcement data sources, along with public data such as information from credit agencies, said Mr. Sena. But the system is still hampered by having data stored in separate systems that can't easily communicate. For example, classified reports from different federal agencies can't be accessed on the same machines, he said.
Last year, the Senate subcommittee on investigations released a report questioning the effectiveness of the centers in fighting terrorism and protecting privacy.
Citizens also play a role in investigations, with the growing culture of crowdsourcing. Users of online discussion board 4chan sifted through photos and spotted a man seen at the marathon finish line wearing black pants, a black shirt and a white hat. That man appeared to bring a backpack to the race, but it seemed to be gone later.
Researchers at Northeastern University in Boston formed a 10-person social-media research team to run a similar project, scheduled to launch Thursday, which would allow people to upload photos from the attack and tag clues. They said they plan to continue their project even if a suspect is found.
Write to Geoffrey A. Fowler at firstname.lastname@example.com


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Irene E. Frost, 91, of Bloomville, passed away at 12:08 p.m. Thursday, Sept. 13, 2012, at Ruffing Family Care Center, Bloomville.
She was born April 11, 1921, in St. Stephens, Bloom Township, Seneca County, to John and Rose (Dannemiller) Ball. She married Louis C. Frost June 5, 1945, and he preceded her in death April 2, 1989.
She is survived by a son, Harold (Lorie) Frost of Sycamore; two daughters, Catherine Stinchcomb and Louise Frost, both of Bloomville; four grandchildren, Rhonda (Benjamin) Foos, Annette (Nathan) Balduf, and Gregory and Nevada Frost; four great-grandchildren, Dalton, Brittany, Taylor and Taryn; and two sisters, Rita Bentz of Tiffin and Gertrude (Gene) Durnwald of New Washington.
Article Photos
She also was preceded in death by her parents; a brother, Herbert Ball; and two sisters, Victoria Schoen and Alma Weisenauer.
Irene was a 1939 graduate of Bloomville High School. She was a member of Our Lady of Hope Catholic Church, Attica, and Caulfield American Legion Post No. 434 Ladies Auxiliary. She enjoyed playing bingo and cards and worked for many years at Oakview Locker, Lykens.
Her Mass of Christian burial will be 10:30 a.m. Monday, Sept. 17, 2012, at St. Stephen Chapel (Our Lady of Hope Parish), CR 6, Attica, with the Rev. Paul A. Fahrbach and the Rev. Joseph Szybka officiating. Burial will follow at St. Stephens Cemetery, Attica. The rosary will be prayed 20 minutes prior to Mass.
Visitation will be 2-4 p.m. and 6-8 p.m. Sunday, Sept. 16, at Lindsey-Olds Funeral Home, 3085 S. SR 19, Bloomville, OH 44818, (419) 983-2111. The rosary will be prayed Sunday at 1:30 p.m. at the funeral home.
Memorial contributions may be made to the church or to Alzheimer Association.
Online condolences may be made to the family at www.lindseyoldsfh.com.

subset: commoncrawl


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Be involved, be active and be a leader.
The student clubs and organizations at Cal Lutheran represent a range of interests and welcome both graduate and undergraduate students. Browse the directory to find a club or start one of your own.
News & Announcements
- 2015-2016 Clubs Approved for Recognition
Mon July 6, 2015
ASCLU Senate has approved clubs for recognition for the 2015-2016 academic year.
Clubs Directory
A wide range of interests, passions and communities are represented by student clubs. Browse by name or category.
Join a Club
Want to get involved on campus? Student clubs and organizations are a great way to get connected to life at Cal Lutheran.
Start a Club
Interested starting you own club? Find out everything you need to know, and submit your application to get started.


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Watters Creek in Allen has been recapitalized, signing new tenants, adding more signage visible on N. Central Expressway
A joint venture group led by Fort Worth-based Trademark Property Co. has acquired the debt of Watters Creek at Montgomery Farm in Allen.
The mixed used development that includes office, residential lofts and 356,000 square feet of retail is being recapitalized by the group that includes Trademark, Coventry Real Estate Advisors, Southern Land Co. and PCCP.
The joint venture acquired the debt from a group of banks led by PNC Bank. Los Angeles-based real estate, finance and investment management firm PCCP provided the capital for the transaction. PCCP targets high quality real estate with distressed capital structures that need the workout expertise combined with fresh equity capital.
"The recapitalization allowed ownership to take advantage of the opportunity to purchase the existing loan at a discount and to provide additional capital for future improvements," said Coventry principal Brian Moss.
Watters Creek is located on the southwest corner of Bethany Dr. and North Central Expressway. The restructuring provides ownership the time and flexibility to allow for "Watters Creek to reach its full potential over the next few years," the owners said in a statement.
"The project has stable ownership that will enable us to complete the original vision by adding additional density at the southern end of the project, an LED billboard sign on U.S. 75 and other new amenities," said Trademark CEO Terry Montesi.
New leases have been signed with Z Gallerie for an 8,500 square foot store. Texas Health Resources has leased 6,000 square feet. Another 10,000 square feet of additional tenants will be announced soon, Montesi said.
The center has a two-level Borders store that's been vacant for a year. It's not clear if any of the new tenants are filling that space.
Additional improvements under consideration include "build to suit" office space, a children's play area, new shade structures and other property enhancements. Management is also discussing possibilities with a hotel group, townhouse developers and additional retail anchors. The group said it may build additional multi-family units on the southern end of the property.


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I try to keep in touch with my friends pretty regularly- so much due in part to social media or email, of course, but in the busy-ness of life I've definitely sent off what I meant as a sincere note to a friend and then realized that I didn't even take my time, so it sounded quite short... and did my tone come across the right way? I can "like" a Facebook status but can go another few months (or more) without really connecting.
With a hand-written note, I'm making myself sit and take a moment, and savor an uninterrupted thought. I can write it all out- and I can't usually edit or backspace gracefully with my pen y'know
and that is how it should be sometimes.
Honestly, I'm more likely to send a card on a regular ol' day for no reason at all, and less likely to send a card on a birthday or anniversary. I'm more than loving that Hallmark has asked me to partner with them to start a new conversation...
Let's talk about celebrating everyday moments in addition to special milestones. The real and not just the ideal. The unexpected. You anticipate cards on your birthday. What about how it feels to get one on a regular Tuesday, just because?
Get Carded. For seven days I wrote a card to someone in my life. Hallmark provided me with the cards, and I sifted through them excited to discover to whom I would send each one. Of course it was difficult to choose just seven someones- but I tried to think of people that I don't get to see everyday or who might really appreciate the gesture. The card selection definitely helped me narrow that down (which also made it kind of fun.) I love shopping for cards in general, without someone specific in mind; one pops out at me and I know just who it's for.
Some of these cards are still on their way to unsuspecting mail boxes all over this country. But I thought I'd briefly share with you who I picked, and why:
The first card I sent was to Heather. She is a new friend of mine (a la Listen To Your Mother)- we are still in the getting-to-know-you stage and it's pretty fun. We tend to have these rapid-fire phone conversations or text messages and keep meaning to get together in person but it has yet to happen this summer. I'm thankful for Heather's boldness and I admire her gumption. I look up to her, really. And so I am flattered when she comes to me about a subject I might have some knowledge or experience; it's my pleasure to help. I love when friendship works this way. Heather sent me a text after she received my card this week. We had a little "lovefest" as we call it. Hearing her response made my day. Oh the gifts keep on giving!
The second card was to my bestie Ashlee- sort of the opposite of Heather. Ashlee and I go way back, deeper than even the five years we've known each other (soul sister territory) and one of the cards in my batch instantly made me think of her. I was overdue in sending her a handwritten message- it's one of those things where I need to send a card to say 'not it! Your turn!' She just got engaged! I'm going to be in her wedding! I can't wait to catch up! Also, I MISS HER!
The third card is for my sister-in-law Lisa. She lives far up in Michigan and I just really felt like I needed to send her a note. You know those little nudges? But, I didn't find the time until it was kind of laid out right for me here and by gawly I did it. I finally sent the card I'd been meaning to send! (And I think that is exactly how I started my message.)
I chose the fifth card as a congratulations to my friend Erin. She has been quietly accomplishing a whole lot lately- her latest challenge was completing the Couch to 5K program like it was no big deal (even though it is a very big deal and I just had to let her know I thought so.) This is one of those milestone-y times when I am not the best at commemorating. But these days especially, accomplishments are deserving of a real-live card in the mail. Pats on the back are so the new black. (Um, hey, Hallmark? You can so put that on a card.) Erin emailed me the sweetest message thanking me for being in her corner. I love how she put it. Exactly. Let someone know you're in their corner. Means the world.
The sixth card is to Carter, my middle son. This was a card that I didn't even have to mail. I mean, I guess I could have- and he'd love to get a letter in the mailbox- but I chose to leave it as a surprise on his pillow. Hand-delivered or left on a porch with an iced latte from Starbucks... those are just as good as mail. I wrote to him some things that I've been meaning to say (it's like the To Kids With Love line was designed just for me), but in the excitement of a family of six, the in person moment hasn't come as easy lately.
The seventh card was meant for the other Heather in my life, Heather of the EO. She just had a baby but this card wasn't a congrats on your new baby card. Not that there's anything wrong with that. This was more of a I know we don't ever have time to email so maybe try this crazy thing of calling me on the phone sometime but I know even that's hard and that's OK and also I have been meaning to send you a congrats on your new baby that isn't even so new anymore type of thing. Heather's special and deserves more than that card (like something knitted that I promised to make and still will! promise!), but it's a start. I'm thankful when a card can deliver my intentions much better than a direct message via Twitter.
You can follow the other Get Carded challenges by liking Hallmark on Facebook and let us know if you're inspired to play along. You can also sign up for the e-newsletter down at the bottom of this page. I recommend liking & signing up because there are always good things to come in the future- you don't want to miss out!
WIN $5000! "Like" and fill in the blank at Hallmark on Facebook "______ is a special occasion"
OR WIN HERE! My hope is that even if you don't win, you'll still play along. Maybe even for one day. I'm offering one more chance to win if you leave a comment telling a story about a time a card really made your day, or maybe mention if you have someone in mind you really have been meaning to reach out to. Tomorrow morning I'll randomly choose from all of the other comments (past the first 10) to win a little something something from yours truly- no matter where in the world you live, I'll send it myself.
It'll be awesome.
Hallmark provided all cards, postage, and prizes for this Get Carded challenge, and is compensating me for this sponsored post. I am partnering with Hallmark to shine a light to the Life Is A Special Occasion blogger campaign for the rest of this year. As always, all content and opinions expressed are my own.


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Police search for downtown bank robber
Man took money from downtown Milwaukee Chase Bank branch
Milwaukee Police are looking for a man who robbed a downtown bank on Monday.
Police said that the man pictured above entered Chase Bank, 111 E. Wisconsin Ave., around 2:30 p.m. and demanded money.
Bank employees said the man implied he had a weapon, but one was not seen.
He left the bank with an undetermined amount of money.
Police believe the man is between 25 to 30 years of age. He is described as 5 feet 8 inches tall and weighing around 180 lbs. He had a beard that appeared to be a few days old and was wearing a gray T-shirt, blue jeans and black Army boots.
Anyone who can identify the man shown in the photo is asked to call MPD investigators at 414-935-7411.
Copyright 2013 by WISN.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Source: Slashdot
quote: The correlation with Cosmic Radiation and cloud formation, the sun spot correlations
quote: They will ignore any evidence because they want the money .
quote: But all of that is not needed. Al Gore, et al, all say we are 0.4 degrees hotter than we should be.


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The Annual Report is a "snapshot" of the year for the International Myeloma Foundation. NOTE: In 2008, the IMF changed its fiscal year to begin October 1st and end September 30th. This resulted in a shorter year snapshot for the 2008 Annual Report. Subsequent reports reflect the entire year from October 1st to September 30th.
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RCS Libri Opens a New Chapter in Book Distribution
RCS Libri is a company owned by RCS MediaGroup S.p.A and a major European book publisher. To make its sales team more efficient, it equipped agents with the latest generation of 2 in 1 mobile devices, powered by the Intel® Core™ i5 processor and running Windows* 8. In addition to saving on the production of printed materials, RCS has minimized errors in the order process and laid the foundation for more effective collaboration between agents and headquarters.
• Enhance the efficiency of the sales force. Provide the sales network with a modern tool that can quickly and interactively display the books in the catalog (canvas), so as to allow more time for the relationship with the customer and strategic activities.
• Integrate customer relationship management (CRM) software with SAP*. Adopt mobile hardware platforms that allow the use of CRM and cloud computing, which will then be connected with the management software to automate most of the tasks.
• Simplify the help desk. Reduce the various types of devices and operating system versions to lighten the workload on the IT department.
• Digitization. Replace all the old personal computers of the sales force, characterized by inadequate performance and poor multimedia capabilities, with 65 convertible devices of the latest generation, equipped with Intel Core i5 processors and the Microsoft Windows 8 Enterprise operating system.
• Integration of the sales process. The book catalog (canvas) is now browsable in digital form from the devices' touchscreens. Agents can interact with the customer and place orders directly from the catalog. Sales are recorded automatically by the system and entered into both the CRM and management platforms.
• Reduction of operating costs. The new fleet of computers will be homogeneous in terms of hardware and operating systems. This will free up resources in the IT department and decrease maintenance costs. The use of multimedia and interactive functionality will also create significant savings in terms of paper and other materials used for printing.
Read the full RCS Libri Opens a New Chapter in Book Distribution Case Study.


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Financial Services
Financial Services
Early Stage:
Moreton Financial Solutions
Majority Owners:
Jason Williams
Andy Robbins
Jordan Hansen
Westminster Alumni:
Jordan Hansen ('12)
Launched in 2012
Approximate Yearly Revenue: $100,001-$500,000
Industry: Financial Services
Company Overview: Based in Salt Lake City, UT, Moreton Financial Solutions (MFS) provides investment advisory services for corporations, municipalities, non-profits, credit unions, hospitals, and insurance companies. Although we serve all institutional clients, our primary focus of business and largest potential growth area is currently in the municipal and credit union market. MFS helps institutional customers that carry large cash balances to protect, keep liquid, and earn interest on their cash. Our firm specializes in structuring fixed income portfolios that are tailored to meet the specific liquidity and diversification needs of our clients. By leveraging technology and employing portfolio managers with unique expertise, MFS has built a fixed income portfolio management operation that addresses the specific investment and regulatory requirements of municipalities and credit unions. These industries are currently under served by local financial institutions and investment options are limited. By combining specialized fixed-income regulatory reporting with sophisticated fixed income management expertise, our firm is positioned to grab market share in this special niche market.
Future Growth Plans: A key strength our firm is its ability to handle large increases in Assets Under Management (AUM) without having to increase the underlying number of employees. The three employees should be able to handle an increase of AUM up to around $500 Million. At that point, the firm will likely add a fourth portfolio manager that should be sufficient up to $1 Billion. Our firm's goal is to reach $250 million in AUM within 3 years and $500 million in 5 years.
Major Accomplishments: Our firm began producing revenue within the second month of operations. We have had consistent positive month over month growth since inception.


text:
Experience MIT
MIT's more than just academics. Find out about student activities, volunteer and paid opportunities, and how you can help student government and committees shape your experience here. »
Living at MIT
Everything you need to know about housing; dining options; athletics; and how to get around, to and from campus. »
About DSL
DSL encompasses departments that touch every part of student life. Find out more about who we are and what we do. »


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Winston-Salem, N.C.--For the first time in school history, Winston-Salem State will have the chance to play for the NCAA DII Football National Championship.
Head Coach Connell Maynor and the Rams knocked off West Texas A&M 41-18 to move on to next Saturday's championship game in Florence, Alabama.
Quarterback Kameron Smith completed 15 of 23 passes for 233 yards and two touchdowns.
Maurice Lewis carried the ball 21 times for 118 yards and two touchdowns for the Rams.
WSSU, 14-0 on the season, will take on Valdosta State at 1pm.
The Rams saw their season end in the National Semifinals last year at the hands of Wayne State.
WFMY News 2 Sports


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on February 17, 2013 - 1:00 AM
The Common Council will hold a public hearing at 2 p.m. Tuesday on the sale of approximately two acres of land and easement rights near the Inner Harbor to Harborcenter Development LLC.
The Council also is expected to vote on the land sale, which calls for the Buffalo Sabres' development arm to pay $2.2 million for the land, north of First Niagara Center. The Sabres are planning a $170 million complex that will include two indoor ice rinks, a hotel, parking ramp, restaurant and hockey training center.
Also this week:
• The Common Council will hold its pre-meeting caucus at 11 a.m. Tuesday in Room 1417 of City Hall.
• Public meetings to discuss the Michigan Street African American Heritage Corridor Management Plan will be held at noon and 6 p.m. Tuesday in Council Chambers.
The meetings are hosted by Ellicott Council Member Darius G. Pridgen, and the management plan will be presented by Karen Stanley Fleming, chair of the corridor commission.
• The Zoning Board will meet at 2 p.m. Wednesday in Room 901 of City Hall. The board will address a height variance for a new medical office building on the Buffalo Niagara Medical Campus and an application for a live music license at Acropolis restaurant, 708 Elmwood Ave.
• The Preservation Board will meet at 3 p.m. Thursday in Room 901 of City Hall.


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Killzone 2 for PS3On: PS3
Sony's FPS is coming to the PlayStation 3. Despite a lukewarm reception on PlayStation 2, this is one of the most hyped games for the system.
Stuck on Killzone 2? We've got you covered!
Don't panic! Our cheats will see you through.
Killzone 2 was originally meant to be Killzone 3
Did Guerrilla have a secret PS2 Killzone in the works?
The Week in Review: Don't expect to play that second-hand game next-gen edition
The Week In Review is a weekend feature which takes a fine-toothed comb over the week that was, hoping to point your eyes in the direction of news, features, videos and reviews which I deem to be worthy of your precious time.
Killzone 4 launching on PlayStation 4, releasing in 2013
Next-gen Killzone is a PS4 launch window title, VideoGamer.com source's comments suggest.
Killzone 1 heading to PlayStation Network
Guerrilla Games' Killzone, the first entry in the now established FPS franchise, is coming to PlayStation Network, Sony has confirmed.
EDGE says Guerrilla is working on next Killzone
The next instalment in the PlayStation exclusive Killzone franchise is currently underway at Dutch studio Guerrilla Games, reports the Christmas issue of EDGE magazine.
View AllScreenshots
Game of the Year 2009
Game of the Year 2009
Flash and Thunder Pack Trailer
Flash and Thunder Pack Trailer
Making of Part 2
Making of Part 2
Making of Part 1
Making of Part 1
Video Review
Video Review
Cinematic Intro
Cinematic Intro
Salamun Bridge Gameplay
Salamun Bridge Gameplay
Visari Square Gameplay
Visari Square Gameplay
VC1 Flamethrower Gameplay
VC1 Flamethrower Gameplay


text:
Excel 2
- When:
- http://www.ubalt.edu/alc
- Description:
registration fee: $10/UB students, $20/UB staff and alumni, $30/general public; payment is required to reserve a seat
Perform more complex calculations in several tables. Create multistep formulas and replicate patterns of numbers, dates, etc. without typing. Use pivot tables and functions to summarize your data (count, find average and locate maximum and minimum values) and display your results in charts and graphs.
required: skills covered in Excel 1; see www.ubalt.edu/computerskillsworkshops for details
- Contact Name:
- Achievement and Learning Center
- Contact Email:
- email@example.com
- Contact Phone:
- 410.837.5383


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So, after discussing it, my husband and I decided that we were going to ask that we do not have visitors at the hospital and for a week after we get home. We want that time to bond as a family. Truthfully, my husband is agreeable to whatever I would like to do, but we are presenting a united front when we tell our parents.
Now, I'm beginning to rethink this. I'm sticking to my guns as far as not wanting visitors at home for the first week, but I'm wondering if we should allow family MIL, FIL, and my parents only to visit at the hospital AFTER the baby is born. I know that I won't be able to handle a bunch of other relatives, but my MIL is about 45 minutes away, my FIL is about an hour away, and my parents are about 3 hours away.
I have issues with MIL, DH has issues with his father, and my mother can be very overbearing.
There is no way I want them in the delivery room, or even in the waiting room as I'm giving birth, but maybe it's unreasonable to ask them not to come to the hospital at all. BTDT moms, what do you think?


text:
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
Wall Street Decline Takes Its Toll...
Between 2005 and 2010, 200 of the 487 products receiving FDA approval involved a contract manufacturer, according to PharmSource. [© Andrei Merkulov - Fotolia.com]
CMOs may be short for "contract manufacturing organizations," but increasingly such businesses are partnering with biotechnology customers in ways that go beyond simply mass producing their pills or vaccines.
"Most of our partnerships are manufacturing. However, we do have a few collaborations with companies that can help extend our capabilities," Dave Cunningham, Goodwin Biotechnology's (GBI) director of business development, told GEN. GBI announced one such partnership last month. The CMO will work with Rafagen to carry out cell-line engineering.
Biotechs of all sizes have long farmed out their manufacturing operations to CMOs. Demand for CMO services has swelled even more over the past decade. Between January 1, 2005, and June 30, 2010, 200 of the 487 products receiving FDA approval involved a contract manufacturer, according to PharmSource. Big pharma, desperate to cut costs as blockbuster drugs come to the end of patent protection, has increasingly shut down manufacturing plants or sold them off to CMOs.
Contract service providers (CSPs) "should continue to grow as the pharmaceutical industry disaggregates and moves towards a more flexible business model," concluded a 2010 report by BioCrossroads, a nonprofit organization that promotes growth of the life science industry across Indiana. The report is titled "Industry Developments in U.S. Biopharmaceutical Contract Services."
"Biomarker services and the need for larger clinical trials will provide opportunities for additional growth moving forward. However, with the consolidation of the pharmaceutical industry and the continued trend of strategic partnerships between CSPs and their clients, many companies in the sector will be faced with finding new revenue sources or merging with other providers in the sector," the report noted.
Indiana, for example, has grown its segment of CMOs and other third-party service providers to more than 8,000 workers and 40 companies as of last year. Those numbers are expected to increase in coming years, according to the BioCrossroads report.
Since 2008, Eli Lilly has shed about 1,000 jobs by selling off three Indiana plants. Lilly did sign long-term service contracts with their buyers to ensure that it still has access to the expertise and skill of plant employees. Covance bought Lilly's Greenfield, IN, site for $50 million in 2008 and signed a 10-year deal to assume responsibility for Lilly's toxicology testing and other R&D support activities there. The Greenfield facility has doubled employment to 500 jobs since the Eli Lilly sell-off.
Lilly's Tippecanoe Laboratories plant in West Lafayette, IN, is now run by Evonik Industries and refocused on making APIs and specialty chemical and animal health products. Finally, an Indianapolis plant was sold off last year and is now used by Fisher Clinical Services for outsourced clinical trial material management. Fisher Clinical, which expanded into Indiana with the deal, now handles the distribution of clinical trial materials for Lilly throughout North America.
"A lot of the infrastructure was built up around Lilly, and then it has continued to grow a little bit faster," Brian A. Stemme, project director for BioCrossroads, explained to GEN.
Besides Lilly divesting production plants, another reason why CMOs have grown in Indiana, according to Stemme, is the presence of strong academic research institutions like Purdue University, which has an industrial pharmaceutical program.
The potential for growth has made CMOs attractive to professionals looking to build up biotech clusters without the advantages the nation's largest bioclusters enjoy, such as a big community of venture capitalists or dozens of universities and independent research institutions.
Stemme added that the recession and the sluggish recovery that has followed have continued to pose numerous challenges for CMOs and other providers of outsourced services for biotechs. "One of those challenges includes a smaller set of customers who are now bigger and needing more services globally. So, smaller companies will need to have specific niches, expertise, and excellent client service," added Stemme. Other challenges include uncertainty over healthcare reform and tighter spending controls.
In disclosing financial results on June 10, publicly traded CMO Patheon cited another challenge. The firm said that the 2011 fiscal year saw "an unusual level of contract cancellations and delays in the PDS (pharmaceutical development services) business during the first half of 2011." Patheon, however, said that it expects its second-half underlying operating performance to improve "significantly" from second quarter levels.
"Our PDS business experienced an unusual level of contract cancellations and delays during the first half related to customer regulatory approval and clinical trial outcome issues as well as industry M&A activity. This created short-term weakness in demand at some of our PDS sites, which had staff for a higher level of activity," Patheon CEO James C. Mullen remarked. "Contract cancellations are not typically a major PDS issue, and we have not seen further material issues over the last few months."
It is believed that CMOs can achieve success by focusing on niche manufacturing strengths. No matter what, there will be production contracts to be had, since biopharma is expected to continue cost-cutting over the next few years. More manufacturing operations across the country will likely get dropped while adding some capacity in lower-wage Asian countries.
That growth should spur opportunities for CMOs to differentiate themselves short-term. Longer-term, it's still early to say whether smaller biopharma companies will generate enough new therapies to make up for the contraction in the pipelines of corporate giants, and thus whether CMOs can expect the same level of growth that the last few years have brought.
Alex Philippidis is senior news editor at Genetic Engineering & Biotechnology News.
Alex Philippidis is senior news editor at Genetic Engineering & Biotechnology News.
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In 2009, Charleston County decided to close its garbage-burning incinerator, revamp its solid waste program and set a goal to recycle 40 percent of its trash. It has made significant strides toward that goal over the past four years, but much remains to be done.
Q: How much has the county's recycling rate increased?
A: The county was recycling about 10 percent of its garbage in 2009 when it set its ambitious goal. It's now recycling 25 percent.
Q: Are county taxpayers paying less for the solid waste program?
A: Yes. In the 2010 fiscal year, the last year in which the county burned most of its garbage in an incinerator in North Charleston, the county spent about $43 million on its solid waste program. In fiscal year 2012, which ended June 30, it spent about $29 million.
The county continues to charge a $99-per-home fee for solid waste, but two years ago, it gave homeowners a $25 rebate.
Q: When will the popular All-in-One recycling program be rolled out countywide?
A: Soon, but county leaders can't give a specific date. About 50,000, or 45 percent, of the 110,000 homes from which the county collects recyclables now are in the program, which allows residents to mix all of their material in one large roll cart. Another 25,000 homes from neighborhoods throughout the county will be added in June. The county regularly adds new neighborhoods to the program. The single-stream program dramatically increases the number of homes that recycle and the amount people bring to the curb every other week.
Q: With all of this expansion, have any controversies come up?
A: Yes. There's controversy over who should run the program, and its use of consulting services. County Council voted 5-4 this week to continue allowing county attorney Joe Dawson to run the program until several specific tasks are completed, including renegotiating landfill and transfer station contracts; finding a site and designing a new recycling facility; and rolling out the All-in-One recycling program countywide. The majority of council members think Dawson has been successful running the program. They want him to reach a logical stopping point before handing over the reins to county administrator Kurt Taylor. But several council members think Taylor should run the program now. Dawson is paid $7,500 per month for his work with solid waste.
The county also pays Kessler Consulting about $30,000 per month for its work to revamp the program. The county always has relied on solid waste consultants. It paid two solid waste consulting firms more than $4.6 million between 2000 and 2008.
Q: What about Dorchester and Berkeley counties?
A: Berkeley County started offering curbside pick-up on a subscription basis ($7.50/quarter) in unincorporated areas of the county and in the municipalities of Hanahan, Daniel Island, Goose Creek and Moncks Corner in July. Residents can mix all of their recyclables in 18-gallon bins, but the county hopes to transition to roll carts within the next year. The county also offers recycling drop-off sites .
Dorchester County doesn't offer curbside recycling but has recycling drop-off sites. Private haulers offer curbside service, mostly in the lower county and Summerville.
Q: What does the future hold?
A: If Charleston County is going to reach its 40 percent goal, it has to increase commercial recycling. The county will begin to push that after it has built a new recycling facility. Its existing recycling center couldn't handle a huge increase in commercial recycling now.
The county is trying to acquire its preferred site, a CARTA facility on West Montague Avenue in North Charleston, but that plan hit a snag a few weeks ago. County leaders say they still are working to land the facility. If it doesn't work out, they would have to choose another site.
Reach Diane Knich at 937-5491 or on Twitter @dianeknich.
De Angelo Jackson picks up a recycling can in a Charleston County single stream recycling truck Wednesday.×


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STYLE: Belgian Dark Strong Ale
Aroma: Complex, with a rich malty sweetness, significant esters and alcohol, and an optional light to moderate spiciness. The malt is rich and strong, and can have a Munich-type quality with an occasional caramel, toast and/or bready aroma. The fruity esters are strong to 25 moderately low, and can contain raisin, plum, dried cherry, fig or prune notes. Spicy phenols may be present, but usually have a peppery quality not clove-like. Alcohols are soft, spicy, perfumy and/or roselike, and are low to moderate in intensity. Hops are not usually present (but a very low noble hop aroma is acceptable). No diacetyl. No dark/roast malt aroma. No hot alcohols or solventy aromas. No recognizable spice additions.
Appearance: Deep amber to deep coppery-brown in color ("dark" in this context implies "more deeply colored than golden"). Huge, dense, moussy, persistent cream- to light tan-colored head. Can be clear to somewhat hazy.
Flavor: Similar to aroma (same malt, ester, phenol, alcohol, hop and spice comments apply to flavor as well). Moderately malty or sweet on palate. Finish is variable depending on interpretation (authentic Trappist versions are moderately dry to dry, Abbey versions can be medium-dry to sweet). Low bitterness for a beer of this strength; alcohol provides some of the balance to the malt. Sweeter and more full-bodied beers will have a higher bitterness level to balance. Almost all versions are malty in the balance, although a few are lightly bitter. The complex and varied flavors should blend smoothly and harmoniously.
Mouthfeel: High carbonation but no carbonic acid "bite." Smooth but noticeable alcohol warmth. Body can be variable depending on interpretation (authentic Trappist versions tend to be medium-light to medium, while Abbey-style beers can be quite full and creamy). Overall Impression: A dark, very rich, complex, very strong Belgian ale. Complex, rich, smooth and dangerous. History: Most versions are unique in character reflecting characteristics of individual breweries.
Comments: Authentic Trappist versions tend to be drier than Abbey versions, which can be rather sweet and full-bodied. Higher bitterness is allowable in Abbey-style beers with a higher FG. Barleywine-type beers (e.g., Scaldis/Bush, La Trappe Quadrupel, Weyerbacher QUAD) and Spiced/Christmas-type beers (e.g., N'ice Chouffe, Affligem Nöel) should be entered in the Belgian Specialty category, not this category.
Ingredients: Belgian yeast strains prone to production of higher alcohols, esters, and sometimes phenolics are commonly used. Soft water. Complex grain bill: Belgian pils or pale base malt, Munich-type malts for maltiness, other Belgian specialty grains for character. Candi sugar to lighten body and to add color and flavor (if dark candi is used). Noble-type, English-type or Styrian Goldings hops commonly used. Spices generally not used; if used, keep subtle and in the background. Avoid US/UK crystal type malts (these provide the wrong type of sweetness).
Vital Statistics:
IBUs: 15 - 25+
Commercial Examples: Rochefort 10 (blue cap), Westvleteren 12 (yellow cap), Chimay Grande Reserve (Blue), Rochefort 8 (green cap), St. Bernardus Abt 12, Gouden Carolus Grand Cru of the Emperor, Abbaye des Rocs Grand Cru, Gulden Draak, Kasteelbier Bière du Chateau Donker
Wyeast Strains:
1214 - Belgian Abbey™
1762 - Belgian Abbey II™
3522 - Belgian Ardennes™
3711 - French Saison


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Exhibit celebrates 75 years of Klussendorf Award
Exhibit celebrates 75 years of Klussendorf Award
Stop by the National Dairy Shrine Museum in Fort Atkinson to view an exhibit honoring past winners of the Klussendorf award.
by Chelsey Johnson, Hoard's Dairyman Editorial Intern
As you visit Madison for World Dairy Expo, consider making a stop at the National Dairy Shrine and Hoard Historical Museum in Fort Atkinson, Wis. An exhibit in honor of the 75th Anniversary of the Klussendorf Trophy is on display with photos and memorabilia of past winners. In addition, the Klussendorf Trophy, made by Tiffany and Company is showcased at the museum.
Since the idea was developed in 1936, the Klussendorf award has been considered the highest showmanship honor in the dairy show ring. The trophy is awarded to an individual who exemplifies the qualities that made Arthur Klussendorf so popular amongst his peers, sportsmanship, ability and endeavor. In 1937, Mrs. Klussendorf presented the trophy to the first winner, Olaf Kjome of Minnesota.
See the introductory panels of the display to learn more about how the award began.
Since Arthur Klussendorf, was one of the most popular and talented cowman of his time, three of his closest friends, Harry Strohmeyer, Earl Hopper, D.V.M. and Gordon Hall met after his funeral to discuss an award in his namesake. Through their efforts, they raised funds for the signature trophy created by Tiffany and Company of New York, N.Y.
Today, several other awards recognize past Klussendorf Honorees. The Klussendorf-MacKenzie Award, Al Hay Award, A.C. "Whitie" Thomson Award, McKown Award and the Merle Howard Award were all created to recognize outstanding individuals that enjoy showing cattle.
If you are unable to make it to the museum to see the display, you can look at our online version of the display.
The Klussendorf exhibit follows other successful one-time exhibits, including 2010's 125th Anniversary display of Hoard's Dairyman magazine and last year's Brown Swiss exhibit. A decision has been made to continue with special exhibits in the Historical Museum's Mary Hoard Gallery each year during the time of World Dairy Expo to showcase the dairy industry.
The National Dairy Shrine Museum and the Hoard Historical Museum are located at 401 Whitewater Avenue in Fort Atkinson. The museum is normally open Tuesday through Saturday between 9:30 a.m. and 4:30 p.m. However, during World Dairy Expo week, the museum will also be open Sunday, September 30th and Monday, October 1st. There is no admission fee; cash donations are gratefully accepted. For more information, call 920-563-7769 or email firstname.lastname@example.com.
at www.facebook.com/DairyWellness.
Click the icon to subscribe to Hoard's at Expo blog and get the blog sent to you.


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3050 North IH 35
Directions Round Rock, TX 78681
"Rock Bottom Pricing"
Here at Round Rock Nissan, we only speak one language: cars. Of course, we're fluent in its many dialects, including commercial vehicles, parts, service and finance. If you're interested in learning the lingo yourself, stop by and see us at our Round Rock, Texas showroom today. Whether you hail from Georgetown, Austin or Killeen, we'll be happy to bring you up to speed.
How will a new Nissan such as the Altima, Rogue, Sentra, Versa and Frontier elevate your daily commute?
Well, for one: the peace of mind that comes with an impressive list of cutting-edge safety features. Additionally, there are a host of creature comforts. These come in the form of supportive seating, temperature control, a killer sound system and other A-list entertainment options - You catch our drift. Everything about the new Altima, Rogue, Sentra, Versa and Frontier - from their time-tested endurance to their fun-inspired performance - is designed to give you something to look forward to.
In addition to having a wide selection of new Nissan cars, trucks and SUVs - we also carry a large inventory of commercial vehicles including passenger and cargo vans. No matter what you're needs are we can help you find the perfect vehicle to elevate your business.
Want or need less of a commitment? Round Rock Nissan has a dynamic collection of hand-picked used cars as well. Also perfect for taking to the roads of Round Rock, Georgetown, Austin and Killeen, they look like new. They even drive like new. Really, the only non-new thing about them is their highly-approachable pricing.
Once you find your perfect new Nissan, or used car, match, Round Rock Nissan will custom-craft a car loan or lease designed not only to help you comfortably meet immediate financial goals but long-term plans as well. Whoever said financing is the hard part is wrong.
Looking for Nissan auto service done right? Then bring your vehicle to the Round Rock Nissan service center. Our experts do more than perform oil changes and tire rotations. They can diagnose any problems that your vehicle may have and implement a fix sure to take years off of aesthetics or performance. What's more, they do it all using time-tested, genuine Nissan parts.
Round Rock Nissan encourages you to browse our site to learn more about our new and used Nissan vehicles, parts and service. If you're ready to take a test drive, simply stop in and see us in person at 3050 North IH 35 Round Rock, Texas during regular business hours. We're happy to get you behind the wheel.


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LEWISTOWN - C. Larry Stewart, 72, of Lewistown, died at 2:50 a.m. Thursday, Oct. 18, 2012, at Geisinger Medical Center, in Danville.
Born Feb. 23, 1940, in Burnham, he was the son of the late Carl H. and M. Evelyn (Van Art) Stewart.
In addition to his parents, he was preceded in death by three brothers.
Article Photos
C. Larry Stewart
Surviving are: his wife, Margaret M. (Dunn) Stewart, whom he married on Aug. 25, 1962; children, Eric K. Stewart and Michelle R. Knepp and her husband, John, of Lewistown; five grandchildren, Andrew, Cullen, McKenna, Abbey and Allix; brothers, David Stewart and his wife, Donna, Kurt Stewart and his wife, Judy, and Scott Stewart and his wife, Cynde, all of Lewistown.
Larry was a 1959 graduate of Chief Logan High School, served in the U.S. Army from 1963 to 1965, worked at Standard Steel until 1986 and was a Christian by faith.
He loved spending time with his grandchildren, hunting, camping and target shooting.
Larry was a member of the Lewistown Pistol Club, Mifflin County Sports Club and Yeagertown Fire Co.
A funeral service will be held at 11 a.m. Wednesday, Oct. 24, at Heller-Hoenstine Funeral Homes Inc., 108 First Ave., Burnham, with the Rev. Robert Davidson officiating.
A viewing will be held from 7 to 9 p.m. Tuesday, Oct. 23, at the funeral home.
Interment, with VFW Post 7011 honors will take place in Juniata Memorial Cemetery.
Memorial contributions may be made to: Lewistown Pistol Club, 25 Ridge Runner Lane, Lewistown, PA 17044.


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Developers of DTC Genetic Testing Are...
Quadruple Helices Appear To Have Role...
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
The gold standard for gene-expression analysis, qPCR, has been extensively studied. Standard protocols have been published and multiple instruments for cycling with real-time detection are commercially available. So, how can there be anything new to talk about?Well, some laboratories have designed new methods for signal generation that offer additional benefits, while the focus on infectious disease has forced other researchers to concern themselves with PCR primer design in the development of validated assays.All these scientists, whose work will be presented at CHI's upcoming "Quantitative PCR—Getting the Basics Right" conference in San Diego, have novel tips, tricks, and techniques to offer that can help solve specific issues in qPCR applications. At Johnson & Johnson, Elisa Mokany, Ph.D., a scientist in nucleic acid analytic technology, and her colleagues developed a novel detection methodology based on multicomponent nucleic acid enzymes (MNAzymes). MNAzymes, which form in response to accumulating target amplicon, use a nonprotein-based enzymatic reaction to cleave a generic reporter probe, thereby separating the fluorophore from the quencher moiety. The ability to accomplish this is found in the elegant design of the MNAzyme. They are composed of two oligonucleotide components, referred to as partzymes A and B. Each partzyme consists of a target-specific sensor arm, a partial catalytic-core sequence, and a generic probe-specific reporter arm. The sensor arms of the two partzymes are designed to bind to adjacent sequences in the target amplicon (DNA or RNA). This allows the catalytic core to form and provides a binding site for the generic reporter probe on the reporter arms of the MNAzyme. Self assembly of the MNAzyme is facilitated by binding to a specific target sequence in the amplicon. Subsequent cleavage of the bound generic reporter probe results in fluorescent signal generation. The ability of MNAzymes to discriminate between closely related sequence variants is based on the design of the target-specific sensor arms. With strategic design of the sensor arms, MNAzymes have been shown to discriminate between single base polymorphisms without bias."MNAzymes provide an extremely flexible detection method that is compatible with most pre-existing PCR primer sets under qPCR cycling conditions," says Dr. Mokany. "We have demonstrated their effectiveness in seven different real-time PCR machines. The fluorescent signal is only generated in the presence of the specific target amplicon. This signal is linear over a broad range without background."The most important contribution of MNAzymes, however, is in their application for multiplex analysis. The catalytic core and reporter arms are generic. A typical multiplex analysis is set up with a series of generic reporter probes with different fluorophores that bind to the respective reporter arms. In closed-tube reactions, Dr. Mokany reports that she has been able to demonstrate detection of different signals in a multiplexed reaction for simultaneous quantification of up to five target transcripts without cross talk.Daniel Adlerstein, Ph.D., head, molecular diagnostics, at Diasorin, and his colleagues developed an efficient signal-generation alternative by incorporating a quenched fluorophore on the 5´ tail of the PCR primer. The key to FLAG (fluorescent-amplicon generation) is the use of a thermostable endonuclease PspGI that is stable throughout the cycling process. The signal evolves when PspGI cleaves off the quencher moiety using the restriction site that separates the quencher and fluorophore on the accumulating amplicon. The story doesn't stop there, however. The group at Diasorin also uses PspGI to selectively amplify mutated codon 12 KRAS sequences in the presence of the wild-type sequence. Preferential amplification of mutant KRAS sequences (codon 12) is enabled, because the recognition site for PspGI overlaps the wild-type sequence in codon 12 of the KRAS oncogene. Cleavage at this site prevents the accumulation of wild-type amplicons, resulting in preferential amplification of the low-abundance mutant variants.
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100Funkadelic - 'One Nation Under a Groove'
"Here's a way to dance my way out of my constriction," croons the most famous song from George Clinton's sci-fi funk collective. Quite literally, the act of dance used as a means of social change, a populace implored to boogie its way to freedom. A hell of a lot more fun than a worthy protest folk song, frankly.
99The Pretenders - 'Brass In Pocket'
Chrissie Hynde's ultimate calling card, as she sidles up, leather jacket on, lips in a snarl - possibly with a tambourine in her hand to kill the mood, but still super cool. Rarely has a song so basic sounded so alluring, although the less said about the waitressy video, the better.
98James Brown - 'Get Up (I Feel Like Being A) Sex Machine'
Songs about sex are very rarely that sexy themselves, falling down either on the side of awkward or icky. But 'Sex Machine' positively throbs and thrusts, keeping you in the moment and in the mood, building to an eventual happy finish.
97Bob Marley & The Wailers - 'No Woman, No Cry'
Bob at his lilting best, looking back at his impoverished past in the ghettos of Trench Town in Jamaica. Imploring his girlfriend not to cry with the promise that things were going to get better, its hypnotic charm make it one of the best-loved of Bob's catalogue.
96Kate Bush - 'Wuthering Heights'
Serene, pristine and deranged, nobody should underestimate quite how shocking it was when the teenaged Bush emerged to the world with this haunting piano melodrama of her own creation. Casting herself as tragic heroine Cathy from Emily Bronte's gothic romance, perhaps the reason so few pop songs are based on classic novels is that they'd have to live up to this.
95Siouxsie And The Banshees – 'Hong Kong Garden'
Siouxsie Sioux proved herself as far more than a scenester from punk's notorious 'Bromley Contingent'. This oriental-flavoured day-glo riot proved she had the personality and musical muscle to forge a career that would outlast and outgrow the scene that she came from. It was very quickly acknowledged as a classic.
94The Slits - 'Typical Girls'
The zippy and infectious signature tune from the definitive female force of the punk rock scene. Ari Up makes a simple, direct, but biting attack on the perceived attitudes to femininity, at once offering up a delicious and mischievous alternative.
93Can - 'Oh Yeah'
As the 70s hit their stride, Cologne's krautrock pioneers evolved into more expressive and extreme forms of jazz-inflected sound. Their third record 'Tago Mago' is described as their most extreme, but this has stood the test of time as one their most beloved. Although rather less catchy than the Ash track of the same name.
92Public Image Ltd - 'Public Image'
In which the former Johnny Rotten did the unthinkable at the time and reinvented himself in an outfit just as compelling as the Sex Pistols. Musically a more mature strain of post-punk, but not lacking in his signature bile, here was a lacerating attack on what he saw as his exploitation at the hands of Malcolm McLaren.
91The Beatles - 'The Long And Winding Road'
The Beatles nudge into the '70s by the skin of their career, and we find McCartney at his most McCartneyish for the band's swansong. Looking back on one the most thrilling journeys in music history, Macca sounds sentimental and weatherbeaten, a man finding peace, and the song is one of the warmest and fuzziest of the decade.


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August 29, 2007
Wordless Wednesday: Oh Snap
38 comments:
That shirt is SO CUTE!ReplyDelete
I am starting to see the p-cheeks and nose. Is it just me?ReplyDelete
What an adorable shirt! Looks like he's enjoying his sucker. happy ww.ReplyDelete
That is a cute shirt. And that face in the second picture...SO funny!!ReplyDelete
Cute shirt! I second that....love the face in the second pic!ReplyDelete
Love that smileReplyDelete
Very sweet!!! He a a beautiful smile.ReplyDelete
Love the smiles!! Cute shirt!ReplyDelete
Totally cute shirt. And shots!ReplyDelete
Super cute! LOVE the shirt! (your kids are "stylin"! lol)ReplyDelete
What a cutie. Love his shirt!ReplyDelete
Ok, Grayson has THE COOLEST tshirt collection ever!ReplyDelete
Dig that shirt! The kid is pretty darn cute, too!ReplyDelete
Happy WW!
Mom, I want some lollipops too. Hehhe. Happy WW.ReplyDelete
Cute shirt - and the model is a cutie too! :)ReplyDelete
The shirt looks so adorable on him!ReplyDelete
can I have a bite? very adorable.ReplyDelete
What a priceless face in the 2nd picture. Cute!!! Happy WW!!!ReplyDelete
love that smile!ReplyDelete
love the shirt, the smile, and the sucker! heheReplyDelete
Love the shirt- and that face! In that second pic he him looks soooo much like Mimi!ReplyDelete
He is such a handsome boy! And the shirt - very cool!ReplyDelete
Love it! He looks so proper in the second photo! Like he's British!ReplyDelete
Jane, P&B Girls
How cute! Him and the shirt. :)ReplyDelete
OMG! My boys say that ALL. THE. TIME.ReplyDelete
In fact, they have gotten me to saying it.
Someone is sure enjoying his lollipop. lol
so sweet! I had a laugh the other day when my mom said "oh. snap." without even noticing, or realizing why I was laughing. :)ReplyDelete
I think we have those suckers too, the organic ones from that health food store by us?
Cute babe!ReplyDelete
Cute shirt!
Delicious looking pop!
- Audrey
That is too cute! (the shirt *and* the kid). My son said Oh Snap! the other day for the first time and it cracked me up.ReplyDelete
That shirt is adorable...I love it!ReplyDelete
What a cute shirt that is, happy WW Mama!ReplyDelete
What a sweeeeet face! Happy WW :)ReplyDelete
awe love the saying ;-) Ohhh snap!ReplyDelete
So cute...Gray's face in the second pic looks like the frog on his T...ReplyDelete
too cute...both baby and shirt!ReplyDelete
love the shirt and the little man.ReplyDelete
btw, we got our ab/cd shirt from trendy tadpole this weekend. so cute!
What can I say, he's adorable! Oh yeah, the shirt's cute, too. :)ReplyDelete


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- Flat Rate Shipping. Any Size Order! -
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HOME Baltimore Ravens Gear Baltimore Ravens Ladies Baltimore Ravens Ladies Sweatshirts & Fleece over $60 (30 items) Product ID: 1717512
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Celebrate your fandom with this Baltimore Ravens Stella full zip hoodie. This stylish hoodie features Baltimore Ravens graphics along with two front pockets. It also features a drawstring hood and soft fleece lining to keep you warm on those chilly game days.
- Rib-knit cuffs and waist
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- 57% Cotton/43% Polyester hood lining
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- Hood with drawstring
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- Brand: G-III 4Her by Carl Banks
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on May 2, 2013 - 12:01 AM
On Friday and Saturday, the Buffalo Philharmonic Orchestra and Music Director JoAnn Falletta are presenting a preview of their Carnegie Hall concert taking place May 8. If you can't make it to Manhattan, here's your chance to join in the festivities.
The Spring for Music festival encourages unusual repertoire, and BPO Music Director Falletta has pretty much promised the moon. The concert begins with the ethereal "Morning Prayers" from "Life Without Christmas" by Giya Kancheli, a composer born in 1935 in Georgia, which was then a part of the Soviet Union. The soulful piece looks back on a soulless era – the oppressive Stalinist regime, when religion was outlawed. It is unusually scored to include strings, electric bass and the recorded voice of a boy soprano.
After intermission, the orchestra grows in size to perform the sprawling, atmospheric Symphony No. 3, "Ilya Muromets," of the Russian Romantic composer Reinhold Glière. The symphony was inspired by a Russian myth of a warrior who won victory after victory over monsters and foes until he defied God – and was defeated by the rapidly multiplying heavenly hosts.
"It's very, very moving," Falletta says. "The more I know of the piece, the more I am completely astounded by it."
Celebrate "Destination: Carnegie Hall" at Kleinhans Music Hall at 10:30 a.m. Friday and 8 p.m. Saturday. Admission is $27-$74.
Friday's concert is part of the BPO's "Coffee Concerts" series. Arrive early for doughnuts and coffee in the Mary Seaton Room. Saturday concertgoers are invited to arrive at 7:30 p.m. and gather in the Mary Seaton Room for a champagne toast.
For more information, call 885-5000. – Mary Kunz Goldman


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- September 21: Hyundai Recalls Azera To Prevent Seats From Moving recalls | 10 days ago
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Top Definition
A slang used in corporate to share the dismay or feeling of loosing a situation. Initiated by group of friends in is a rahe now.
I went for a date and the girl was a guy. I was like what the Girish man...
por rishabh2541 03 de Agosto de 2013
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take a stand to end split ends
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Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
NSCLC is "Major Battlefield" as Merck,...
LC-MS Gains Favor Due To the...
Developments in stem cell culture, regenerative medicine, and drug discovery are creating demand for cell culture under true physiologic conditions mimicking the atmosphere within living beings.
While former goals were just to keep cells alive and genetically stable, avoid contamination, and grow cells quickly in large numbers, investigators now know the subtle effects of unnatural cellular environments.
Atmospheric oxygen concentrations of in vitro cultures are far higher than that experienced by in vivo cells, and this difference has far-reaching consequences. Room air oxygen levels in cultures increase oxidation, mitochondrial activity, and forced cell proliferation, which inhibit other cell functions, causing misleading data as to tumor cell sensitivity to drugs and radiation.
Traditional labware, that is, flasks, bottles, and plates, are ambient atmosphere dependent—they take on the gas characteristics in which they are incubated. Without complex active interventions, cells are exposed to room air.
Cells in flasks or plates grow as a monolayer below a shallow layer of media directly exposed to air containing 21% oxygen, rapidly and constantly dissolving in the media, while true cellular oxygen levels are much lower. Room air contains almost no carbon dioxide, so supplemental tanked CO2 is supplied, while low relative humidity in the lab requires a saturated water environment (water pans).
Excluding oxygen is particularly problematic, requiring sealed incubators, nitrogen flushing, and repeated attention to prevent the ingress of omnipresent atmospheric oxygen. A plethora of complex hypoxia chambers and glove boxes have been developed as active interventions to bring oxygen, carbon dioxide, and humidity levels in line with true physiologic conditions, but even so, wide fluctuations and failure of these active interventions is a constant danger.
Instead of trying to replicate natural conditions, a new strategy employs engineered devices, called Ducted Respiratory Chamber (DRC) bioreactors. Celartia's Petaka® G3, instead of attempting to impose "normal" gas conditions on the cells through active incubator controls, passively allows cells to maintain their own oxygen, carbon dioxide, and humidity levels.
These levels are maintained automatically and independently from the laboratory or incubator conditions. Because the DRC devices act passively, they are inherently far simpler, more reliable, and less expensive than traditional methods of active gas control.
While the passively controlled gas environments within the DRC are far simpler than the active interventions required by today's incubators, they are actually far more dependable, as they are driven exclusively by natural laws.
The Petaka G3 DRC design is shown in Figure 1. The cell culture chamber is isolated on the injection side from the atmosphere by a self-sealing silicone injection port that allows the closed introduction of media and cells, including most eukaryotic cells types, small early-stage embryos, tissue fragments, and even needle biopsies.
On the venting side, the culture chamber is partially isolated from the atmosphere by an engineered, semi-closed respiratory duct having two major portions. Closest to the reaction chamber, a series of small chambers act as water vapor condensers blocking evaporation, preventing alterations in media osmolarity, even at 37ºC for 10 to 20 days at 10% RH.
The chambers also act as a capillary breaker to prevent media flow into the second portion, the respiratory duct that controls internal gas levels. The length and cross-section of the respiratory duct is engineered to partially restrict the diffusion of oxygen from the high levels of ambient air to create lower, physiologic levels of dissolved oxygen in the reaction chamber.
Observing Fick's Law, as oxygen is consumed inside the culture chamber, decreasing the partial pressure of oxygen in the media, oxygen diffuses from the outside atmospheric (higher) partial pressure, through the respiratory duct, to the lower partial pressure inside.
Diffusion is proportional to the concentration gradient, as regulated by the engineered design of the respiratory duct, and occurs entirely spontaneously and without outside intervention.
At the same time, the respiratory duct partially retains carbon dioxide from cellular metabolism to maintain a physiologically normal mild acidosis to balance pH. All gas exchange with the outside environment occurs through a 0.2 micron filtered vent, preserving the internal sterility of the device but allowing in and out gas movements to prevent pressurization issues when filling and emptying the bioreactors. These physical features of the Petaka G3 are labeled in Figure 2.
Cell culture in DRCs does not need supplemental oxygen-nitrogen balancing or CO2 and humidity sources, eliminating the entire panoply of gas tanks, regulators, sensors, microprocessors, and water pans. This creates a doubled benefit: not only are cells cultured in more normal physiologic conditions, but the mechanics and costs of cell culture are greatly simplified and reduced.
Because the gas environment is automatically maintained, cultures can be incubated in virtually any kind of chamber providing warmth, and nothing else.
Many genes promoting cellular differentiation and expression are downregulated at atmospheric oxygen tensions. Naturally induced oxygen levels and cell growth in the DRC are depicted in Figure 3.
A series of DRC bioreactors were seeded with neonatally derived cardiomyocytes, 106 cells per DRC in RPNI 1640 media, and incubated in room air at 37.5ºC. At time zero (left, Figure 3) seed cells and media at room air O2 (~120 mm Hg) are injected into the DRC. Cells proliferate, consuming O2, causing the O2 level within the DRC to begin to fall, but restricted diffusion through the respiratory duct partially replaces O2.
At about 5 x 106 cell count, internal O2 levels enter the upper limits of physiologically normal tissues (~50 mm Hg). At about 8 x 106 cell count, O2 diffusion through the respiratory duct approaches compensatory levels for O2 consumption. Cells enter a differentiation phase, shown by a leveling of the doubling rate, expanding protein expression and normal gene expression, and are harvested while still within the band of normal tissue O2 levels (5−50 mm Hg).
Because the cells control their own gas environment, there is little effect from outside gas conditions, and the DRC is effective in atmospheres from 500 meters below sea level up to elevations of 4,000 meters, and in relative humidity levels between 10% and 100%.
The DRC changes the paradigm of cell culture, replacing nearly a century of active attempts to humanly intervene to manipulate gas exchange with a self-regulating design driven by natural laws of diffusion to create dependable, and truly physiologic, gas environments.
Emilio Barbera-Guillem, M.D., Ph.D., is CSO, and Michael Gallagher, M.D. ([email protected]), is associate science officer at Celartia.
Emilio Barbera-Guillem, M.D., Ph.D., is CSO, and Michael Gallagher, M.D. ([email protected]), is associate science officer at Celartia.
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Winter 1999, Vol. 31, No. 4
Choctow and Chickasaw Enrollment, Part 1
Kent Carter
The Pacific Coast Hooligans of World War II
Suzanne Dewberry
Race Relations in the United States and American Cultural and
Informational Programs in Ghana, 1957-1966
Kenneth W. Heger
A Soldier's Story: The Records of Hubbard Pryor, Forty-fourth United States Colored Troops
Robert Scott Davis, Jr.
Prologue in Perspective: In NARA's Records, the POW/MIA Search Goes On
John W. Carlin
Looking Back on the Twentieth Century: 1976-1999 in Photographs
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Genealogy Notes: U.S. Marines in the Boxer Rebellion
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As Immunotherapy Revolutionizes the Cancer Treatment...
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Researchers and patients have a common desire for safe and efficacious medicines. As a result, all of the tools that aid in the process of creating new drug products are highly valued. Software tools won't replace data-gathering pharmacokinetic and toxicology experiments; however, researchers can leverage the data mining and computer modeling capabilities using already amassed information to make predictions to facilitate drug discovery and development.
Understanding and modeling the basic absorption, distribution, metabolism, and elimination (ADME) processes for organisms exposed to drugs contributes to the safety assessment of a drug product, which requires not only the evaluation of a drug substance, but also safety profiles of its metabolites.
The ability to predict the potential risk associated with metabolite vulnerabilities can be used to help redesign and select more promising candidates for further and more rigorous testing throughout the phases of discovery and development. Obviously, simple and confident estimation of candidate risk is desired.
In vitro studies, however, still involve extrapolations, and conducting all experimental tests for candidates would require prohibitive investments of animals, time, and money. Overall costs should be alleviated by early rejection of compounds with problematic metabolites and reallocation of resources toward more promising candidates. These factors increasingly emphasize the value of reliable in silico property prediction as part of the process.
Each organization has its own preferred and dynamic battery of experiments and computational assessments for new chemical entities and derived metabolites, including objectives to:
Despite the complexity of biological systems in organisms, software enabling the prediction of ADME properties from molecular structure is available. While a variety of approaches to individual predictions have been expounded, it is possible to find an extensive set of prediction capabilities, including those addressing the objectives mentioned in this article. The use of logP, logD, solubility, and pKa for predicting ADME properties such as permeability, oral bioavailability, and distribution are well documented and will not be discussed further.
Hepatic metabolism by cytochrome P450 enzymes is the major clearance route for xenobiotics. These biotransformations can lead to either an increase or decrease in toxicity. Using in silico tools such as the cytochrome P450 predictive modules in the ACD/ADME Suite from Advanced Chemistry Development (ACD/Labs), researchers can identify whether compounds will be substrates and/or inhibitors of the five major drug metabolizing enzymes—CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2.
Furthermore, the regioselectivity module predicts the sites most likely susceptible to metabolism in human liver microsomes and proposes possible biotransformation reactions. These predictors also offer the ability to add experimental data to extend chemical space coverage and improve prediction accuracy.
Graham A. McGibbon, Ph.D. ([email protected]
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As strange as it sounds, a magazine article led to the resurrection of Tim Alderson's career.
The 23-year-old pitcher's bizarre story of seeing his 93 mph fastball inexplicably drop to 85 has been well-documented the past two years. Alderson spent all that time trying to figure out what happened, working on anything and everything he could to correct the problem and prevent himself from becoming a sad baseball footnote.
Luckily for Alderson, ESPN The Magazine helped him find the answer.
Article Photos
Mirror file photo by J.D. Cavrich
The Curve's Tim Alderson has his fastball hitting 93 mph, back to where it was a few years ago before it mysteriously dropped into the mid-80s.
Now the right-handed pitcher is getting ready to start Tuesday's game at Bowie, and in some ways, it will be like starting over in his career.
"Things are going really well," Alderson, who's back to throwing 93 mph, is now finally able to say after a very trying couple of years.
The first turning point for the pitcher occurred in February of 2011, when ESPN The Magazine profiled him in a lengthy story titled, "Terminal Velocity." The story detailed Alderson's past, which includes:
* Being a first-round draft pick (No. 22 overall) of the San Francisco Giants in 2007 and going 13-4 with a 2.79 ERA during his first full season;
* Getting traded straight up for former National League batting champ Freddy Sanchez in 2009; and
* Mysteriously seeing his fastball drop with the Curve in 2010, which led to him getting crushed in Altoona (5.62 ERA) and after getting demoted to Single-A Bradenton (6.98 ERA)
The heart wrenching part of the magazine story detailed how Alderson went back to throw in front of his high school coach, Eric Kibler, to see if he could figure out what was wrong.
"You were a better pitcher when you were a freshman in high school," Kibler said in the story.
That article also featured general comments about velocity from Alan Jaeger, who runs a pitching academy in Los Angeles. Jaeger specializes in building up arm strength through various exercises and then letting the pitcher take part in an individualized long-toss program.
Traditional theory says that pitchers shouldn't do a lot of long toss - about 300 feet, give or take, depending on the pitcher - for fear of hurting their arm. Instead, most pitching coaches prefer them throwing about 120 feet.
Neither Alderson nor Kibler had ever met Jaeger before that story appeared in ESPN The Magazine. But Jaeger's comments caught Kibler's attention because the high school pitching coach also is a proponent of the long-toss theory.
"We did a long-toss program similar to what [Jaeger] did, and Tim had a lot of success in high school and his arm was healthy," Kibler told the Mirror by phone from his home in Arizona.
The magazine story ran too late for Alderson to make major changes for the 2011 season, and the career starter did show some improvement with his fastball as he moved to the Curve bullpen and was in the 89 mph range.
When the 2011 season ended, Kibler helped arrange a phone conversation between Alderson and Jaeger, and Alderson decided to attend a four-day clinic at Jaeger's complex in Los Angeles in January.
Alderson, who had searched for answers for two years, finally found what he was looking for in those four days.
Jaeger introduced the pitcher to his long-toss program, and it just clicked.
"That's pretty much everything," Alderson said. "As far as the physical part of it, I feel like that's all it took."
The program designed by Jaeger, who did not return a phone message from the Mirror, is unorthodox by industry standards but also very simple. It begins with the pitcher doing a series of stretch band exercises.
"Throwing a baseball overhand is one of the most strenuous motions in sports," Kibler said. "[The stretching exercises] gradually warm up the muscles in your arm and warm up your body to throw a baseball."
It's onto the field from there, and the pitcher starts throwing from about 50 feet, then gradually moves back about 10 feet at a time. After a few minutes, the pitcher can wind up about 300 or more feet away, and the goal is to throw the ball that distance with a high arc to strengthen the entire arm.
Alderson, who does the long-toss program just about every day, said he makes about 10 throws at the maximum distance.
After that, he starts coming in a little at a time, throwing harder as the distance gets shorter. Ultimately, the pitcher gets back to 60 feet and is throwing just about as hard as he can.
"It just kind of freed me up and helped out mentally to not worry about mechanics or body parts doing what at what part in the delivery," Alderson said of the long-toss routine. "If you watch me throw out there, I'm not thinking about anything. I'm just trying to throw it as far as I can."
Somehow, some way, that routine has led to Alderson's velocity increase back up to as high as 93 mph this season.
Curve manager P.J. Forbes said the difference in Alderson as a pitcher from when he first saw him at Bradenton in 2010 is "night and day."
"For me the biggest thing is the attitude," Forbes said. "He was pretty defeated in '10. ... I'm happy for him because he seems to be in a good place mentally, and that's half the battle in this game."
The Pirates also deserve a lot of credit for Alderson's turnaround, not so much because of what they've done, but for what they've allowed the pitcher to do himself.
Most organizations have their pitchers on a structured throwing routine, so all of them do roughly the same thing. But that clearly wasn't working for Alderson.
"To be a pitching coach, you can't clone them," said Kibler, who has been a coach for more than 30 years and stresses individual attention based on each player's strengths.
Alderson bought into the long-toss program in January, but the Pirates could have shut him down and prevented him from doing it once spring training and the regular season started. Instead, the organization let the pitcher continue his individual throwing program rather than forcing him to stick to theirs.
"He did it all himself," Curve pitching coach Jeff Johnson said. "His long-toss program, he kind of managed that himself, told me what he wanted to do, and I said, 'Go do it.' We did it as an organization, let him do what he thought he needed to do from that standpoint, and it's worked."
Why does it work?
"There's a whole method behind it," Alderson said. "It's really stress free on your arm, and it's not taxing it too much.
"That just kind of freed me up," he added, "and I can just be athletic and not worry about mechanics because it takes everything I have to throw the ball as far as I can. So I'm just trying to take that final throw onto the mound and just air it out."
Kibler credits the Pirates for breaking from the status quo and understanding Alderson needed to be given the freedom to try something different like the long toss.
"I think that's great of them to do that, I really do," Kibler said. "I think somebody said, 'OK, this is not working, let's try something else.' That's awesome they did that because look at what's happened."
The results speak for themselves.
Alderson, with the increased velocity, started the season with seven scoreless innings out of the Curve bullpen to earn a promotion to Triple-A. He only lasted two appearances there - three shutout innings in one, two runs in one inning in the other - and the Pirates decided to send him back to Altoona because he wasn't getting much work with Indianapolis.
"I had a great time up there," said Alderson, who added he wasn't disappointed about coming back to Double-A. "I learned a lot, even though I wasn't there very long. I had a good first outing, and the second outing I got hit around a little bit and I just learned what it takes to get guys out up there."
Alderson continued his success upon rejoining the Curve and ran his Double-A scoreless innings streak to 14 over seven appearances. The streak ended in his last appearance Wednesday against Bowie when he allowed three runs in three innings.
That extended outing was used to help get Alderson ready to go back into the Curve's starting rotation for the first time since midway through the 2010 season. He now has his fastball back and is working on a changeup to go along with his sharp curveball, so the Pirates want to see if he once again can become the prospect they'd envisioned as a starting pitcher when they traded for him in 2009.
"When you've got confidence in your fastball that you can get outs with your fastball and not try and trick guys all the time, that's a big confidence boost," Forbes said.
Given all he's been through, Alderson could have shut it down mentally and never regained his prospect status. But he hung tough, tried enough different things until he found something that worked and now hopes to reap the benefits.
"I've put in a lot of hard work the past couple years," he said, "and it's finally paying off."
Back on track
Tim Alderson first made it to Double-A with Connecticut in 2009, before getting traded to the Curve late in that season. A look at his down-and-up numbers since then:
Tim Alderson, RHP


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Great Explorations®
Multicolor Filofun - 40 Strands
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What can you make with Filofun? What can't you make?! Weave, wrap, loop, and tie the Filofun into a number of cool creations, making keychains, bracelets, necklaces, anklets, animal friends, and more! The possibilities are as limitless as your imagination. Europe's hottest tween trend is now stateside, providing hours of creative, constructive fun. With its tubular design and bright colors, this is not your parents' lanyard! Comes with 40 strands of Filofun. Ages 6 and Up.


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Do you have more than one Apple TV in your house? Are you the techy in your community, forced to install and set up XBMC on Apple TVs for all those people you know and love? What if there were an easy way to simply clone the XBMC installation from one device to multiple others? Well, you can. This process can be used for a variety of reasons, but the most popular would absolutely be:
- Backing-up your current XBMC set up (allowing you to restore to it at any time)
- Building an XBMC template (if you will) to help setting up other Apple TV's quicker & easier
- Creating a standard of XBMC, including add-ons, for installing on your other iDevices (iPad, iPhone, etc.)


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Enroll Now!
What's the single biggest difference between professional authors and novices? Professionals know how to structure novels and stories for maximum dramatic effect. This course helps you develop the same story structuring skills the pros use. You'll understand how your passion, theme, premise, and characters help you create the structure of your story, and you'll discover how viewpoint, dialogue, pacing, and many other techniques are used to build scenes and move your story from beginning to end.
Each assignment in this course helps you develop your own original novel or story. As you apply each technique, your story will take shape, with a clear path from beginning to end. And whenever you have questions or insights to share, you can join your instructor and classmates in the Discussion Area for some interactive brainstorming! Before you know it, you'll be prepared to ...write fiction like a pro.
Steve Alcorn is the published author of a wide range of fiction and nonfiction works including the mystery A Matter of Justice, the historical novel Everything in Its Path, the romance Ring of Diamonds (under the pseudonym Sharon Stevens), and an illustrated journal of his travels around the world called Travel Kid. During the past decade he has helped more than 10,000 students turn their story ideas into reality, and many of his students have published novels they developed in his classes. When he isn't writing and teaching, Steve is the CEO of Alcorn McBride Inc., a leading theme park design company.


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Health & Balance
Does Sugar Make Your Heart Sweeter?
April 14, 2014 -- Celebrity Snickers pitchmen Joe Pesci and Don Rickles show that "You're not you when you're hungry."
In a Snickers commercial, Pesci and Rickles make rude comments to strangers they meet at a party. Now a new study suggests that the commercial might have a hint of truth: Hunger really may lead to greater aggression.
In the study, though, the aggression was directed not toward strangers, but toward someone much closer -- your spouse.
The researchers found that lower blood glucose levels predicted more aggression toward spouses, although some psychologists are skeptical of that theory.
Glucose is the sugar in your blood that your body uses for fuel.
"Numerous studies have found a relationship between low glucose levels and poor self-control," the researchers write in the Proceedings of the National Academy of Sciences. "When glucose levels are low, people have more difficulty controlling their attention, regulating their emotions, and overriding their aggressive impulses. Some evidence suggests that low glucose levels might even increase the risk of violent criminal behavior, including spousal abuse."
Hunger and Anger
The study involved 107 married heterosexual couples. They measured their blood glucose levels with a monitor twice daily for 3 weeks, before breakfast and before bedtime.
This is where the study gets a little unusual: Besides a glucose monitor, participants received a voodoo doll and 51 pins. The doll was supposed to represent their spouse. Every evening, in private, the participants stuck pins in the doll. How many depended on how angry they felt toward their spouse.
Voodoo dolls might seem like an unusual research tool, but study researcher Brad Bushman, PhD, says an earlier study by one of his collaborators showed the worth of their use.
At the end of the 3 weeks, the couples came back into the lab, where they were told they were going to play a computer game against their spouse. The goal: Be the first one to press a button after a square on the screen turned red. The winner would then get to blast the loser with loud noise through headphones. The noise was a mixture of irritating sounds, such as fingernails scratching a chalkboard and dentist drills. The winners got to pick the noise level and duration. If they were feeling warm and fuzzy about their spouse, they could choose silence instead of noise.


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