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Published November 1, 2013
There will be plenty of hissing, moaning, flapping, croaking, puckering, African chants, electrically enhanced sound and more when the intense, eye- and ear-opening Dutch sound poet, digital artist and experimental performer Jaap Blonk visits UB this month.
Blonk will lecture and perform at two events that are free of charge and open to the public. Timely arrival is requested so as not to disrupt the performances.
His visit is sponsored by the UB Techne Institute for Arts and Emerging Technology, and the Department of Media Study.
Blonk will discuss his art and its roots in sound poetry, improvisation and new music, and present historic examples of sound poetry, as well as his own work, at a lecture from 1-3 p.m. Nov. 12 in the Center for the Arts Screening Room, 112 Center for the Arts, North Campus. The lecture will include live performance; projection of texts and scores; sound examples, including work with other musicians with electronics; and video fragments. A question-and-answer session will follow.
Later that day, Blonk will give a performance of "Dr. Voxoid's Next Move" from 7-8:30 p.m. in the CFA Screening Room.
This improvisational performance is likely to include sound, strangely compelling songs in Blonk's "personal English, which he calls "IngleTwist"; electronic and acoustic phonetic processes, samples from John Cage's Solos for Voice and other sources. Blonk calls this a "Dadaist experiment," and as he is performing is not sure what his next move will be. "It may be a knight's jump, a king's stately step or a bishop's stealthy sneak-through," he says.
Blonk is a self-taught composer, performer and poet who has presented his work throughout the world. Born in Holland in 1953, he was influenced by mid-century German artist Kurt Schwitters, whose work spans and represents the Dadaist, Constructivist and Surrealist movements. Early studies in mathematics and musicology led Blonk to vocal performances that began with recitations of poetry by other artists and became improvisations employing his own compositions and modes of delivery—he "plays" his cheeks, lips and throat to spectacular effect, for instance.
He began working with electronics around 2000, first using samples of his own voice, then employing pure sound synthesis. As a vocalist, Blonk is known for his powerful stage presence, almost childlike freedom in improvisation and keen grasp of structure.
For information about Blonk, contact Holly Johnson in the Techne Institute at 645-2533 or firstname.lastname@example.com.


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Winner! The 2005 Parents' Choice Gold Award and the 2005 National Parenting Publications Gold Award!
Developed by Trapezoid's Paul Reisler in collaboration with the Nashville Chamber Orchestra, Kid Pan Alley: Nashville includes songs co-wr...more
Developed by Trapezoid's Paul Reisler in collaboration with the Nashville Chamber Orchestra, Kid Pan Alley: Nashville includes songs co-written by more than 1,000 children from 40 different Nashville area schools and features top Nashville talent including Amy Grant, Delbert McClinton, Kix Brooks (Brooks & Dunn), Raul Malo, Beth Nielsen Chapman and many more.
Kid Pan Alley brings these professional songwriters and musicians together with school children in a group songwriting process. Through songwriting, children are able to articulate their feelings in a way that aids with the prevention, intervention and healing of crisis situations. Through Kid Pan Alley they develop self-awareness and self-confidence in their own abilities while learning respect for intellectual property in a direct first-hand way. To date, Paul Reisler has collaboratively written over 600 songs with nearly 12,000 children.
Founder and artistic director Paul Reisler comments: "Kids need to know they can be creators and not just consumers. I see what it's like for these students to have their first song recorded by artists such as Suzy Bogguss, Beth Nielsen Chapman, and Darrell Scott, and it's hard not to imagine what they are going to be able to create now that they are off to such a powerful start."
Kid Pan Alley: Nashville received the 2005 Parent's Choice Foundation Gold Award for excellence in children's music, a Gold Medal Prize from NAPPA, and a GRAMMY nomination for the track Scary Things.
About Kid Pan Alley:
Kid Pan Alley started with a brilliant, yet obvious discovery - kids make the best co-writers. Kid Pan Alley is a national children's songwriting project developed by Trapezoid's Paul Reisler in which children are inspired to be creators and not just consumers of music. To date, KPA has written more than 600 songs with more than 12,000 children and won five ASCAP Foundation awards. www.kidpanalley.org
About Nashville Chamber Orchestra:
The Nashville Chamber Orchestra has come to be recognized as one of America's most creative and innovative orchestras, presenting it's unique style of Music Without Boundaries. Under the leadership of music director Paul Gambill and executive director Connie Linsler Valentine, the extraordinary music making of this ensemble has garnered a steady of national media attention plus recordings for Warner Bros., NAXOS, Angel, Almanac, and Alabaster Records, and a national award for Adventurous Programming from ASCAP. www.nco.org
Track Listing
1. Suzy Bogguss / Bouncin' off the Bottom
2. Beth Nielsen Chapman / Little Drop of Water
3. Jonell Mosser / The Cheetah
4. Darrell Scott / Rainforest
5. Mustafa Abdul-Aleem / Goin' to the Park
6. Jimmy Hall / True to Me
7. Raul Malo / Whispering in Spanish
8. Delbert McClinton / Freaky Friday
9. Kaset/Middleman/Lloyd/Vezner / Download it all for Free
10. Kix Brooks / Cartoons
11. Tommy Sims / Can't Remember What I Forgot
12. John Bindel / Scary Things
13. Paul Colman / Pretty Good Day
14. Lari White / Stinky Socks
15. Amy Grant
Christmas in Tennessee
16. Will Hoge / No Fair
17. Nashville Bluegrass Band with Kathy Chiavola / Extra Hand
18. Kim Richey / Sleep All Day

subset: commoncrawl


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Sorry, Boston. Sorry, L.A. Sorry, D.C. Sorry, San Fran. Sorry, the South. You have your claims, no doubt, but they are as the claims of Pushkin, Lermontov, Chekhov, or Gogol. To be sure, Tolstoy and Dostoevsky do not account for the entirety of Russian literature, certainly do not exhaust all options, but they are irreplaceable, irreducible forces upon the landscape of the national literature, and so it is with New York and Chicago, Chicago and New York.
(I say this under the influence of Sister Carrie, which is known as a Chicago novel, but is actually both a Chicago novel and a New York novel, divided almost perfectly down the center—Carrie and Hurstwood leave Chicago about 53% of the way through. That's not quite unique, but it is unusual, almost as unlikely as a Russian novel that combines Tolstoyan sweep and Dostoevskian polyphony.)
The reason for this Chicago-New York division of U.S. literature (and not a more logical coastal binary) can be seen from the simple fact that for Dreiser's novel, the Midwest is west enough. No thought is ever given by any character to moving west (Carrie considers going back to her home in Wisconsin, but Columbia City is really just a transposition of Dreiser's Indiana hometown, so the geography still works in a non-trivial way). Of course, this is an accurate representation of the geographical imagination of most Americans at the time,1 and to some extent is still the mindset of many Midwesterners today.
For instance, although Jonathan Franzen's Midwest is centered on St. Louis and not Chicago, it can certainly be said of The Corrections that "the Midwest is west enough." As I've noted before, the geography of that novel is very peculiar given the claims it makes for comprehensiveness: it's so much a novel about the American family, about American society, about late capitalism, the turn of the century, etc., that what is left out in its cartography is almost shocking:
The way Franzen constructs his novel on a geographic plane is interesting: there is Lithuania, which exists as a sort of netherworld, and then there are three zones of declining cultural intensity or "hipness" or what have you: New York, Philadelphia, and the Midwest. Philadelphia is an intermediate zone—clearly more desirable for the Lambert children than their home in St. Jude (St. Louis?), but nevertheless ritually excused for a certain lack of... you know, New York-ness. Franzen depicts the Midwest sympathetically, but he never tries to redeem it culturally, allowing all the insults his characters fling against it to stand unaddressed and certainly unredressed. Franzen, I would say, does not mind being slightly ashamed of his own Midwestern origins (not that I blame him). But what is fascinating in this schematic geography is how much it excludes—California and the West for one, not to mention the South (including Florida), or the erstwhile Third World. California's exclusion is fascinating given its prominence in so many critiques of late capitalism; its celebrated ethos seems so antithetical to the personal ethic of Alfred Lambert that one might think Franzen had made a mistake in sending Alfred's children East—if Franzen intends to set up an antithetical binary, it should be the younger generation's California vs. the elders' Midwest. And yet the Midwest never has seemed to be in any ideological relation whatsoever to California; can you think of any novel or even film that plays the two off one another?That's a question I still haven't answered, although I know Frank Norris's unfinished Epic of Wheat trilogy does have one novel set and titled as "A California Story" and the other set and titled as "A Chicago Story." (The Octopus and The Pit, respectively.) (And I don't consider Oklahoma the Midwest, so don't try The Grapes of Wrath.) I'd be interested if anyone else has some ideas or examples, but I'm pretty confident that this absence of Midwest-West opposition (or even juxtaposition) characterizes U.S. lit pretty consistently. New York and Chicago it is.
1Cf. William Cronon on "the Great West" in Nature's Metropolis (xviii):
By "the Great West," I mean a region that no longer exists on the mental maps of most Americans. According to nineteenth-century usage, it was the vast interior region of the nation that was neither the North (the region north of the Mason-Dixon line and east of the Appalachians or the Great Lakes) nor the South (the region defined most simply as the losing side of the Civil War). The Great West began either at the Ohio River or at Lake Michigan, and extended all the way to the Pacific Ocean… I am quite confident that for much of the nineteenth century the West began in Chicago, not in Denver or San Francisco. To try to redefine the West to fit our modern vocabulary is to do violence to the way Americans in the past understood that term…"


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"Thank you for your great witness and ministry to Christ and His Church. I have enjoyed listening to Catholic Answers Live and your apologists for a number of years now. It has been very formative and inspirational in my journey towards becoming a well versed and devoted servant of Christ and His people on earth via His Church."
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"I am a Christian and we commit no wrongdoing."
~ Blandina, slave; repeatedly to her torturers who exhausted themselves in the face of her steadfast faith


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on September 2, 2012 - 12:57 PM
, updated September 2, 2012 at 1:28 PM
A safety advisory was issued to students by Buffalo State College police today after two disturbing incidents that occurred near the college during the first weekend of the new school year.
Police said one student was shot in the arm after he and two friends were attacked and robbed late Friday night at the intersection of Grant Street and Potomac Avenue.
Then, two women, including a Buffalo State College student, were assaulted and robbed early Saturday when four males attacked them at Richmond Avenue and Dorchester Road.
The condition of the student who was shot Friday night could not be confirmed today. The college's police chief said the victim, who is in his late teens, is in stable condition and is being treated in Erie County Medical Center.
"Each year, we talk to our students and warn them of the possibility that things like this can happen," said Peter M. Carey, the police chief. "These students did nothing wrong. They were out walking the streets, and they were walking with friends, just as we urge them to do."
Authorities said Buffalo police were called to Grant and Potomac at 11:23 p.m. Friday after three male students were approached by six males. An altercation broke out, and the students were "kicked, punched and robbed," college officials said in the safety advisory.
Shots were fired as the students tried to flee the scene, and one student was shot in the arm, according to the advisory.
"From everything we've been told by Buffalo police, the three students did nothing to provoke this attack," Carey said. "As far as I can see, this was nothing more than six young men who took the opportunity to victimize three others."
"Five or six shots" were fired at the fleeing students, probably from a handgun, Carey said.
In the second incident, around 3:50 a.m. Saturday, two young women - one of them a Buffalo State College student - were assaulted and robbed of their purses at Dorchester and Richmond. No weapons were used and the two victims were not injured, according to the advisory. Four male suspects were involved.
And in an incident not mentioned in the advisory, Buffalo Fire Department officials said three young people suffered minor injuries early today when they fell from a second-story balcony that collapsed during a party near the college campus. It could not immediately be confirmed whether the victims were college students.
Fire Department officials said the incident at 597 Grant St. is under investigation by city building inspectors.
The balcony apparently collapsed "due to the age" of the building, and because it was overloaded with students partying during the first college weekend of the year, fire officials said. The incident happened at a two-story building between Grant and Rees streets, near the college.
Bradley Street is one of a number of streets near the college that features apartment houses that are rented by students. Carey declined to comment on that incident except to say his office will be looking into it.
The safety advisory issued today advised all students to "be aware of their surroundings at all times."
"It is always a good idea to have a companion with you, especially when commuting in the evenings and early mornings," the advisory stated.
Carey said the safety advisory was e-mailed to all students, faculty and staff members. He said the college is required by federal law to notify students and staffers of potential safety problems on and near the campus.
"We need our students to be aware ... the front part of our campus is great, but some nearby neighborhoods" are not as safe, Carey said.
He said the incidents are being investigated by Buffalo police, and said his officers will do "everything we can" to help Buffalo police and the students.
None of the victims' names have been released so far.
email: firstname.lastname@example.com


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The Henry and Stark County Health Departments is pleased to announce it
has been awarded a special grant to encourage health and wellness in our
The Illinois Department of Public Health (IDPH) is awarding $3.5 million
in "We Choose Health" grants to communities in 60 counties in Illinois,
including $56,480 awarded to the Henry and Stark County Health Departments.
These funds will be used to integrate the Coordinated School Health Model at
Cambridge Community Unit School District and Stark County Community Unit
School District. In addition, funds will also be used to encourage smoke
free multi-unit housing.
"We Choose Health" is a multi-year IDPH initiative to encourage and
support obesity and tobacco prevention in Illinois Communities. IDPH
received a Community Transformation Grant (CTG) from the Centers for Disease
Control and Prevention (CDC) to work with communities to implement proactive
health programs.
"It is important that we all work together, area organizations, schools,
local health departments, municipalities and others, to improve the health
of people in our communities," Illinois Department of Public Health Director
Dr. LaMar Habrouck said. "I want to congratulate the Henry and Stark County
Health Departments on receiving one of the 21 "We Choose Health" grants and
encourage everyone in the community to get involved in the exciting new
programs coming your way."
For more information on the programs and services available local
residents through the Henry & Stark County Health Departments call (309)
852-0197 (Main Office) or 792-4011 (Colona) or 852-3115 (Stark) or visit our
website at www.henrystarkhealth.com or find us on Facebook at Henry and
Stark County Health Departments.


text: You really get to see what's what in the "snow specialist" training course. You can accompany the ski run supervisor to the opening of the piste on the mountain, where the secrets of snow sport teaching are revealed to you. Subsequently, you rush from one snow cannon to the next with the snow makers of Grächen; and in the evening you finally flatten the runs with the help of a 200-horsepower snowcat. The one-day program offers plenty of adventures for big and small fans of mountain sports.


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- All
- Angels and Demons
- Atonement
- Basic Reformed Theology
- Irresistible Grace
- Limited Atonement
- Perseverance of the Saints
- Total Depravity
- Unconditional Election
- The Church
- Church Discipline
- Church Leadership
- Creeds and Confessions
- God
- Holiness
- Sovereignty
- Heaven and Hell
- Heresies
- The Holy Spirit
- Jesus Christ
- Cross
- Incarnation
- Resurrection
- Justification
- Last Things
- Man and Sin
- Reference
- Sacraments
- Salvation
- Faith
- Regeneration
- Scripture
- Systematic Theology
- Theological Views
- Roman Catholicism
- Music
- Apologetics
- False Teaching
- Atheism
- Book Reviews
- Children's Books
- Christian Classics
- Christianity and Culture
- Creation
- Ethics
- Fiction and Literature
- Philosophy
- Science
- Bible Figures
- Bible Interpretation
- Bibles
- Books of the Bible
- Gospels
- Covenants
- General Reference Works
- Introduction to the Bible
- Jesus' Ministry
- Life of Jesus
- New Testament
- Old Testament
- Parables
- Prophecy
- Sermon on the Mount
- Ten Commandments
- The Lord's Prayer
- Controversies in the Church
- Alcohol
- Arts
- Bible Translation
- Covenant Theology
- Creationism
- Education
- Gender-Neutral Language
- Law and Gospel
- Lordship Salvation
- New Perspective on Paul
- Politics
- Race
- Sabbath
- Spiritual Gifts
- Women in Ministry
- Marriage and Family
- Divorce
- Parenting
- Practical Theology
- Discipleship
- Evangelism and Missions
- Grief and Death
- Pastoral Ministry
- Preaching
- Worship
- Spiritual Growth
- Anxiety and Worry
- Apostasy
- Assurance
- Conscience
- Depression
- Doubt
- Fellowship
- Godliness
- Guilt
- Humility
- Joy
- Knowing God's Will
- Legalism
- Love
- Money and Stewardship
- Oaths and Vows
- Prayer
- Pride
- Repentance and Forgiveness
- Sanctification and Growth
- Service
- Spiritual Fruit
- Suffering
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- American Church History
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- Eighteenth Century
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Relying on Christ
How can we confess our sins as John tells us to in I John 1:9? Let me make four suggestions: First, know God's Word; second, know our lives; third, know our sins; fourth, confess our sins. When I am self-righteous …Read More
Inexplicable Love
"By this all people will know that you are my disciples, if you have love for one another" (John 13:35). The fish symbol worn as a lapel pin or displayed as a bumper sticker — a gold cross worn as …Read More
Orthodox Obedience
When I was an undergraduate student in college, I decided early on that I would pursue a major in religious studies so that I could begin to prepare for ministry. My education was at a public university and, needless to …Read More
For God So Loved the World
Every Christian believes in limited atonement. That may sound ludicrous to my Arminian friends because it has long been assumed that only Calvinists hold to the dreaded "L" in TULIP. But if the death of Jesus Christ is recognized as …Read More
The Bearer of Iniquity
God has always dealt with the human race through a covenant head. Adam represented us in the garden. If he had obeyed, he would have merited (by covenant appointment) life for himself and the entirety of his posterity. In his …Read More
The Blood of the Lamb
"Without the shedding of blood there is no forgiveness of sins" says the epistle to the Hebrews (9:22). Most of that epistle is taken up with showing how Christ fulfilled the hopes and aspirations of the Old Testament, especially in …Read More
Cur Deus Homo
In the eleventh century, one of the church's most brilliant thinkers, Anselm, archbishop of Canterbury, wrote three important works that have influenced the church ever since. In the field of Christian philosophy, he gave us his Monologium and his Proslogium; …Read More
It Is Finished
As I consider the state of the evangelical church at the beginning of the twenty-first century, I observe a people who have swapped their faith for a bumper sticker and a church that has been caught up with the wrappings …Read More
Are You Listening?
Communication is always a hot topic at management seminars and for consultants that relentlessly try to convince me they can improve our ministry. Having several years of experience in what is known as "cold calling" in a sales-type industry, I …Read More
Therefore, Go
I met a fellow the other day who claimed (in jest) to be a member of a recovery group for those addicted to rededications. Apparently, he had suffered from years of rededicating his life to God. By the time he …Read More


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Your team's colors remind you that they're fighting for Pirates pride with every swing and every run. There's no better way to display your team spirit than sporting Pittsburgh's great colors! Show that the Pirates' colors never fade with this cool Brushed Tricot color-blocked track jacket from Stitches. This soft fleece midweight jacket features twill "Pirates" lettering and logo, along with contrast color sleeves. When you sport your team's colors to the next game, everyone will know you stand with Pittsburgh!
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Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Events for February 2013Open: Sunday 11:00 am - 4:30 pm
Open: 9:30 am - 4:30 pm
Cheekwood is closed on Mondays including Memorial Day & Labor Day
ExhibitionsMarch 31 - August 25 Permanent Residents: Artists from Cheekwood's Collection
February 1 - March 3 The Scholastic Art Competition & Exhibition
February 14 - August 25 Affectionately Yours: American Miniature Portraits and the Stories They Tell
Tuesdays for Tots
February 5 The Wild World of Cheekwood
Cheekwood is home to several botanical collections that will spark your imagination. From silly plant names to funky tree shapes, join us as we use our imaginations and create 'The Wild World of Cheekwood'! This week's project is inspired by Where the Wild Things Are by Maurice Sendak.
February 12 heARTworks
Show your special someone how much you care with a custom-made valentine.
February 19 Tissue Topiaries
Follow along on this charming adventure as a grandson hears about his grandfather's life while exploring his topiary garden. Learn about family, love, and how to sculpt a bush with Grandpa Green by Lane Smith! Stop by the studios to build your own 'sculpted' topiary!
February 26 Yarn Art!
Enjoy cutting, twisting, weaving and gluing your own yarn masterpiece! This week's project is inspired by Extra Yarn by Mac Barnett.
Lunch and Lecture
February 21 House & History: Cheekwood as a Country Place Estate
In the early twentieth century, the combination of fresh fortunes, expansive land purchases, and the emergence of a new profession – landscape architecture – gave rise to grand landscape designs across the country. Learn how Cheekwood, one of the nation's finest examples of a Country Place Estate, fits into this movement. Join us to discover the history of the Cheek family, learn of the design and construction of the mansion and grounds, and explore Cheekwood's place in the country estate era. After the lecture, recognize the grand design and view the fine detail of the estate as you tour Cheekwood's mansion. More ...


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Top Definition
Masturbation...with disastrous results.
Theres no such thing as the verb, "disasturbate" because you never plan it. Disasturbation is the result of a failed attempt. Disasturbation just happens, and boy does it suck when it does.
de cakeofages 24 August 2008
Trending Now
Can you define these popular missing words?
(n) term used to describe when pleasuring oneself ends tragically with an unfortunately timed interruption
"I was jacking off and my cat jumped on my lap right before i came. It was a terrible disasturbation session."
"Then a couple days later, my mom decided to barge into my room to wake me up as i was cranking it under my sheets. I disasturbated twice this week."
"Then a couple days later, my mom decided to barge into my room to wake me up as i was cranking it under my sheets. I disasturbated twice this week."
de systemofanup 19 Iunie 2010
To masturbate during a disaster, or when normal masturbation turns disastrous.
Masturbation turns into disasturbation if you're arrested for doing it in public.
de eosbnnaarsh 08 Noiembrie 2011
The act of masturbation with such ferocity that you actually rip your penis off.
"Dear god - I have ripped my own penis off. I must tell no one about this distasturbation mishap."
de jason 20 Noiembrie 2004
When you feel the sudden need to 'choke yo chicken' when faced with almost certain death.
"Oh no the zombies have broken in through my back doors ;)"
*explosive disasturbation*
*explosive disasturbation*


text:
Do you like oral sex... here's my plan
Okay, here's what I like to do. I'll explain it and you can figure out if you like it or not. I love to start by licking slowly from your clit down to just below your hole. Tease your hole a little then work my way back up to your clit... wait not so fast. I love to lick and flick your inner lips and suck on your outer lips. There's that little spot between your thigh and your outer lips...Read On
Added: 18 Aug 2016 | Category: Flash Erotica |
Avg Score: 4 |
Words: 344 |
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| 3 Comments
The first time Ivan saw her, his cock moved and his exercised body, which was warm to start with, turned hot. He forgot that he was supposed to be watching his ice dancing students practice their twizzles. In fact, he only stopped looking at her when his students skated up to him, waiting for his critique. He struggled for something to say. "A little crisper," he finally offered. They...Read On
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| 33 Comments
She gives me the best orgasm of my life. So far.
I'm sitting in my dorm room working on a 1000-word essay due next week. I was lucky enough to get a private dorm room which left me with a lot of personal time, if you know what I mean. As great as that is, however, it's been giving me a lot of reason to procrastinate and slack off on my assignments. My desk is in front of a window which gives me a view of another dorm building right ahead...Read On
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Is he a cuckold? The first part of a multipart story. The significance of the seesaw becomes clear i
'Home in an hour be ready' the text said. He knew what that meant, be waiting at the door, naked, wearing his cock cage. Well the last bit was easy because she had the key. Standing naked by the front door wasn't hard, at least in theory; but she had put so many mirrors on the walls that there was nowhere to hide. There were days when that was okay too, days when his muscles looked...Read On
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Avg Score: 4.91 |
Words: 6,092 |
Tags: cuckold wife lovers
| 5 Comments
An interesting Friday night in...
It's a Friday afternoon and I get home from work at the office to the smell of a roast cooking in the kitchen so I walk in that direction to try and find my wife, Correna. Correna is a five foot seven white woman with 34B breasts and the cutest little ass I have ever seen. She is 27-years-old and we have known each other for ten years and have been married for two. When I reach the...Read On
Added: 18 Aug 2016 | Category: Oral Sex |
Avg Score: 4.8 |
Words: 674 |
Tags: wife oral straight
| 2 Comments
The Westervelt family sat around the dinner table quietly eating a Thanksgiving meal prepared by their mother. Jeannette, the oldest, sat beside her husband DeRay. Gillian, beside her boyfriend, Andre. Georgina, next to her boyfriend, Jalen. Finally, the youngest daughter, Laura, sat by her father whose head was face pointed straight down into his white mashed potatoes covered in gravy. ...Read On
Added: 17 Aug 2016 | Category: Interracial |
Avg Score: 4.88 |
Words: 4,730 |
Tags: firstinterracial bbc holiday christmas college
| 5 Comments
I took a job as a speedo waiter for a gay party and I was surprised at other 'jobs' I was performing
I saw an add online for "Exhibitionist Waiter for Private Party." It was coming up to Christmas and I really needed the money. I was feeling pretty happy about my twenty year old body these days, I was training for some long distance swimming and spending a lot of time in the pool. With all that training I was starting to tan up nicely and I had lost about 10kgs. Let me quickly explain a...Read On
Added: 17 Aug 2016 | Category: Gay Male |
Avg Score: 4.63 |
Words: 1,846 |
Tags: gay mm speedo speedos swimsuit escort
| 5 Comments
Sometimes, a night out can be very disappointing. This was one of those evenings...
On business trips to a major city I visited every six weeks, one of my delights was to visit a gay action bar, called 'The Hague.' The owner was of Dutch origin, hence the name. It was a very enjoyable bar, and I found it most agreeable to spend a few hours there. In the upstairs section there was a glory-hole area, and three large cubicles with the largest of these, accommodating a sling....Read On
Added: 17 Aug 2016 | Category: Gay Male |
Avg Score: 4.67 |
Words: 1,154 |
Tags: anal fetish fisting group sex humor oral sex voyveur.
| 3 Comments
Jenn attends a conference she will never forget
Jenn liked to stay in fancy hotel rooms and her next trip was no exception. She was boarding the plane to fly to Toronto for a week-long health conference. She did not often get to spoil herself but on occasions like this she liked to do so. When she had booked room where the conference was being held, she opted to upgrade her room from the standard one offered by the conference organizers....Read On
Added: 17 Aug 2016 | Category: Oral Sex |
Avg Score: 4.89 |
Words: 2,578 |
Tags: straight oral
| 7 Comments
I'm in my seventies now and only discovered my bi side when I was in my thirties. We weren't swingers but my ex-wife Barbara and I were very sexually active and uninhibited. We were engaging in oral sex a good ten years before it was socially acceptable. In the mid-sixties when she came home from giving birth to our first child with her pussy shaved. She liked the way it felt when I went down...Read On
Added: 17 Aug 2016 | Category: Gay Male |
Avg Score: 4.85 |
Words: 2,228 |
Tags: threesome
| 7 Comments
Two bored friends brighten up their day with a "party"
"I am gasping for a shag," Ali said. She was my best friend, so she could say that kind of thing in my presence. The fact that she was a woman and I was a man didn't enter into it. It wasn't going to result in me shagging her, because we had already done that a long time ago and it hadn't really worked. We were better as platonic friends, and if some people think that is impossible,...Read On
Added: 17 Aug 2016 | Category: Interracial |
Avg Score: 5 |
Words: 2,005 |
Tags: interracial cunnlingus fellatio anilingus intercourse
| 1 Comment
As Ted and Quinn are nowhere to be found, Hank gets a hot idea.
"Quinn, Ted, Nadine, is anyone here?" I called out, walking in the door. "I'm here," she replied, strolling towards me. As soon as she got to me, she kissed me and wrapped her arms around me. "Whoa, whoa," I objected, pushing her off me slightly. "Are we the only ones here?" "Yes, I wouldn't just kiss you like that right in front of the door like that if I thought there was someone...Read On
Added: 17 Aug 2016 | Category: Novels |
Avg Score: 5 |
Words: 3,851 |
Tags: stepfather/daughter threesome gay sex kissing blow job doggie style making love
| 1 Comment
Cute Dutch Tgirl goes for it
I woke up looking into the smiling face of a pretty redhead. Sunlight was streaming through the curtains of her bedroom. "Good morning, Irene," she said, and she kissed me on my nose. I smiled back and slowly remembered my adventures of yesterday. When I moved my legs it dawned on me that I was still fully dressed. I even had my high heeled boots on. My skimpy black dress was pulled up...Read On
Added: 17 Aug 2016 | Category: Crossdressing |
Avg Score: 4.67 |
Words: 3,399 |
Tags: crossdressing party corset boots lesbian sex
| 3 Comments
Sara continues with my cuckold lifestyle
Joe left us around five o'clock and Sara kissed him goodbye at the front door, she moved his hands to her ass and he looked at me. "It's okay," Sara said softly, "Malc is okay with you seeing and touching me." I smiled and said, "Don't mind me bud, I'm cool with what she wants'." They kissed passionately again before he left and she went upstairs and dressed, she put on a cotton...Read On
Added: 17 Aug 2016 | Category: Cuckold |
Avg Score: 4.83 |
Words: 6,369 |
Tags: cuckold denial exhibitionism wife lover.
| 3 Comments
Studying is never enjoyable, but one supported study after school proved that wrong. I was first in the drama classroom, so I started putting the tables together to make one big table in the middle of the classroom so that everyone could fit around the table. Once I had finished that, I looked at my phone and noticed I had five new texts, every single one of them saying that a...Read On
Added: 17 Aug 2016 | Category: Straight Sex |
Avg Score: 4.33 |
Words: 2,199 |
Tags: teacher student studying
| 2 Comments
Hazel wants to know what her beautiful mother sees in her loser step-dad.
Jerry Holt slowed down as the lane he had been driving on ended and a large opening among the tall pine trees came into sight. "Hey, sleepyhead, wake up, we are here." There was a stirring from the passenger seat and Hazel opened her eyes. She blinked a few times against the harsh sunlight coming over the treetops and then rubbed her eyes. "What time is it?" she said, her voice deep...Read On
Added: 17 Aug 2016 | Category: Taboo |
Avg Score: 5 |
Words: 5,418 |
Tags: taboo stepdaughter stepdad teen blowjob
| 8 Comments
Sexual reunion
She had wondered and wondered about contacting him, it had been three years. Three long years of self loathing, wondering how she could still want him so badly after the way he had treated her, that last night together. Why after their years together had he treated her so badly, demeaning their relationship? Her mind often, quite often lately, went back to the good times. When passion...Read On
Added: 17 Aug 2016 | Category: Love Stories |
Avg Score: 4.8 |
Words: 939 |
Tags: oral sex
| 5 Comments
Billie Jack has sex with Clarisse's foster sister and Clarisse get's it on with her brother in-law
As it turned out, Clarisse had been a foster child herself, but I didn't discover that until her former foster sister invited us out to their lakefront home for the fireworks on the lake. I had never met Clarisse's sister and brother in-law before, but they had invited all of us out to their lake front home for dinner and the fireworks display on the water. They told us that we could spend...Read On
Added: 16 Aug 2016 | Category: Novels |
Avg Score: 4.8 |
Words: 1,788 |
Tags: foster son foster mom foster sister brother in-law fireworks hot tub swapping
| 3 Comments
Claire comes to grips with what she has done, and finds her true self in turn.
Slowly I began to wake up. My thoughts were still cloudy. The taste of alcohol filled my mouth, turning over I saw a few empty bottles on the small table by the bed. The events of the night slowly came back to me. Then I remembered how I had left my boyfriend. Even though I had left him many times before, this time, I was confident that I wouldn't return. I looked around searching for...Read On
Added: 16 Aug 2016 | Category: Group Sex |
Words: 6,670 |
Tags: busty redhead blonde big boobs huge boobs interracial white females
| 3 Comments
My new roommate Will looks great in his speedos and I finally got a chance to suck him off.
OK guys – I've just come in from some riding and I'm going to sit down and write about how I got my roommate Will down to his speedos for some horny fun. Will moved in at the end of November and we share a room in a 3 bedroom condo. Will is nineteen, from Melbourne and plays a fair bit of AFL (Aussie Rules Football). He has just finished his first year of uni and is spending his summer...Read On
Added: 16 Aug 2016 | Category: Gay Male |
Avg Score: 5 |
Words: 2,459 |
Tags: gay first time aussie australian oral blowjob speedos
| 4 Comments
Zantar found Earth women not only attractive, but also eager to be inseminated by him.
I had been searching for a planet like Earth for almost nine years, as had twenty-four other ships like mine. We were deployed on this mission based on the theory and strong belief that biped life like ours was seeded on planets throughout the galaxy millions of years ago. I was the first of the twenty-five ships to find such life and would be a hero when I returned home. But long before...Read On
Added: 16 Aug 2016 | Category: Fantasy & Sci-Fi |
Avg Score: 4.75 |
Words: 1,596 |
Tags: straight sex oral sex first time
| 3 Comments
Deejaying to the masses with a mouth on his cock.
The club was rammed. The music was pumping and from my vantage point in the DJ booth, I could survey the entire room. Groups of friends drank and laughed throughout, but I of course found my gaze drawn to gatherings of the opposite sex. A hen party here, a birthday gathering there, but one particular group caught my eye that night. There were five or six girls, a couple of blondes, brunettes,...Read On
Added: 16 Aug 2016 | Category: Exhibitionism |
Avg Score: 4.88 |
Words: 2,222 |
Tags: blowjob deepthroat oral sex stranger groupie
| 1 Comment
A gymnastics coach does what's necessary to get her team onto the podium.
If you eliminate the sequins and the ribbons, clean off the foundation and the blue eye shadow, ignore the sprained ankles and the rictus smiles, what's left isn't much. Rhythmic gymnastics is a nasty whore of a sport where the judges are little more than johns. I don't like saying this, because I started as a competitor twenty years ago and now I'm coaching the Canadian team. My girls...Read On
Added: 16 Aug 2016 | Category: Reluctance |
Avg Score: 5 |
Words: 4,997 |
Tags: oral bondage threesome mmf facial reluctance humiliation
| 44 Comments
Continuation of my journey into submission
Touch football had been left behind, my life now consumed with academic studies, and learning about myself as well as Barb; her likes, her dislikes, and of course her hot buttons. She was particularly fond of Friday nights in my '48 Dodge, Bessie, out on the old road, our favorite makeout spot. It was rarely travelled, very secluded, a perfect spot to engage in Sex Ed long before it was...Read On
Added: 16 Aug 2016 | Category: Fetish |
Avg Score: 4.75 |
Words: 2,369 |
Tags: obedience submission oral sex masturbation sex orgasm
| 3 Comments
More lessons on the way into the learning submission - along with master's ideas of fun.
The day started almost the same way as the day before. I woke up, felt horribly sore, discovered the bruises and marks from the night before, was denied clothes, got bent over and fucked by both Tom and Josh as casually as if they were talking about the weather. Before getting my first coffee, I got filled up on their cum and then sat at the table, wondering once more if and how this was going...Read On
Added: 16 Aug 2016 | Category: BDSM |
Avg Score: 5 |
Words: 6,640 |
Tags: bondage submission brat smorgasbord ice cubes collar anal plug
| 6 Comments
I get to take photos of a hot couple
Friday I went shopping at my friendly neighborhood WallMart. There are only two cashiers open and they are next to each other. I cannot get into the shorter right hand lane as there is a couple in the left lane and their cart is blocking me. She is behind the cart and he is standing beside it, his back towards me. She looks cute, maybe 30-years-old, and five foot three. She's a wee...Read On
Added: 16 Aug 2016 | Category: Oral Sex |
Avg Score: 4.43 |
Words: 1,926 |
Tags: hot photos couple
| 2 Comments
Violet is feeling down and goes to talk to her friend's parents.
It was a very hectic school year. I had just graduated and my parents were letting me just relax before going to college in the fall. My parents had treated me to a cruise right after graduation. After we came back, they said I could have a party with all my friends. My parents are the coolest parents in the world. They let me have parties all the time. Whenever I have parties, all the...Read On
Added: 16 Aug 2016 | Category: Group Sex |
Avg Score: 4.98 |
Words: 3,292 |
Tags: best friend parents bath massage oral sex threesome ffm
| 33 Comments
My stepfather introduces me to his prison buddy...
At the age of thirteen my family life imploded, when my stepfather was sent to prison for ten years, having been found guilty of manslaughter. He would only be eligible for parole eight years later. I loved my stepfather, and although he was a 'fun' dad, he was also a hooligan who never grew up. He was perpetually in shit and drifted from one job to another. Pool hall fights were a...Read On
Added: 16 Aug 2016 | Category: Gay Male |
Avg Score: 5 |
Words: 2,261 |
Tags: anal group sex voyeur
| 4 Comments
Tamzin meets an African American in a chat room bringing life changing consequences
The engine was still running as she sat parked in her Ford Focus in the hotel car park staring ahead deep in thought. Tamzin was still unsure, still uncertain the she was doing the right thing. Most other women in her place would describe what she intended doing as sheer madness. It was, she had to admit that, but there was something inside driving her onwards. Most other women would...Read On
Added: 16 Aug 2016 | Category: Interracial |
Avg Score: 5 |
Words: 5,313 |
Tags: loving wives cheating infidelity first time cuckold pregnancy romance
| 30 Comments
Neighborhood Housewives get together to have some fun.
"My name's David and I've lived in the same neighborhood my entire life. There's always been something kind of off about it though, like something is always looming in the darkness during the nights or something hiding in the woods, " I said as I sat in front of Alan's camera. "You need to add more emotion to it man, it has to seem real, like you're actually scared," Alan nagged me. Alan...Read On
Added: 16 Aug 2016 | Category: Group Sex |
Avg Score: 4.92 |
Words: 4,923 |
Tags: cum swallowing blowjob group sex lesbian bi-sexual latina milf
| 4 Comments


text:
Crosswords Plus™
- Color:
- multi
- 1
- 2
Description: The Crosswords Plus game offers over 1,000 professionally designed crossword puzzles at multiple skill levels to challenge all types of players. It is all controlled with the stylus and touch screen to input your answers. Within the crossword puzzles, players will discover 4 different skill levels (Easy, Medium, Hard, and Expert) and an accessible Hint system. Players can work through puzzles at their own pace as they improve their skills. Additionally, new crossword puzzles will be available for download through the SpotPass™ feature at no additional charge (wireless Internet access required). You can also unlock new puzzles by connecting with others through the StreetPass™ feature. And with the new giant-sized puzzles, players will feel like they are working through multiple crossword puzzles at one time.
- Over 1,000 professionally designed crosswords puzzles broken into four difficulty levels (Easy, Medium, Hard, and Expert level)
- Intuitive controls to navigate the puzzles and write answers using just the touch screen with a stylus...no more messy eraser bits!
- Accessible hint system to help players move along at their own pace by using points to get an additional clue, reveal a single letter, or even show the answer
- Giant-sized crossword puzzles give players the feeling of working on multiple puzzles at once
- Go online with SpotPass™ to download additional crossword puzzles
- Connect with other players through StreetPass™ to unlock additional puzzles
Please use Parental Controls to restrict 3D access for children 6 and under.
© 2012 Nintendo. Nintendo 3DS is a trademark of Nintendo
Brand: Nintendo
Origin: Imported


text: quote: At one time, we encouraged asbestos to no end. It was the miracle material. CNTs and buckeyballs are todays miracle materials.A year ago, I called for awareness into this field. Not because I want CNT development halted, but because I think if we understand the risks before plunging headlong into them, we (the scientific community) can pre-emptively counter the naysayers with logical, clearly defined studies.http://www.dailytech.com/A+Call+for+Nanopollution+...I strongly advise anyone involved in the field of CNT research to start the analysis now and do it in an honest and thorough manner.


text:
Now is the time to consider legal reforms
December 30, 2012
The last few weeks have provided plenty of fodder for West Virginia on the economic development front....
Excellent addition to this debate raised by the original story from the New York Times and expounded upon by others. It points out a serious flaw in the reasoning of these past contributions to the issue, and that is the tendency to draw straight lines between cause and effect in matters that are never that simple. Such reasoning ignores or gives short shrift to the many other factors that also contribute to ultimate outcomes in complex systems. It seems to be pervasive in our public discourse and found in the discussion of most important issues. While the constraints on space in a forum such as newpaper columns doesn't really facilitate analyzing complicated issues in depth, they are the source most likely to inform and influence public opinion. That is what makes a contribution such as this by Mr. Heath doubly valuable. It demonstrates that the effect of the poor business climate in our state has multiple causes and brings attention to another such contributor.
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text:
'Baywatch': Where are they now?
POSTED: 08:35 PM MDT Jun 12, 2011 UPDATED: 12:00 AM MST Jan 13, 2016
With "Baywatch" star Nicole Eggert celebrating her 44th birthday on Wednesday, join us for a look at where she and her former co-stars are today.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


text:
Expanding Use of NGS Has Largely...
Developers of DTC Genetic Testing Are...
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
Marina Biotech has implemented a furlough of approximately 90% of its employees and ceased most day-to-day operations. The move is based on the company's need to conserve available cash as it does not have adequate funding to continue implementing its business plan. The decision includes the halt of Marina's Phase I trial with CEQ508 in familial adenomatous polyposis (FAP). The firm also has two preclinical programs in bladder cancer and hepatocellular carcinoma.
The company previously engaged banking teams to identify strategic opportunities and to seek additional funding, and their efforts are ongoing. If sufficient additional funds are not received in the near-term, the company may need to further reduce or cease operations completely.
For now the company has negotiated an extension on its secured loan, which is now due and payable in its entirety June 15, 2012, through the issuance to the secured lenders of five-year warrants to purchase approximately 425,000 shares of common stock.
Marina is focused on oligonucleotide-based therapeutics. The company has had a relatively active past year and half in terms of license deals. In fact, in January, J. Michael French, president and CEO, noted, "In the last quarter alone, we brought in over $1.5 million of nondilutive capital from partnerships and licensing agreements.
"In 2011, I believe we were the only company to complete two deals in two distinct oligonucleotide therapeutic areas: RNAi and microRNA," French continued. "In addition, we are the only company with two different technologies in clinical development pursuing two different oligonucleotide therapeutic approaches: RNAi and DNAi."
With regard to this year, French said, "Our goals in 2012 are very straightforward, continue to broaden our drug discovery platform through licenses and partnerships and advance our preclinical and clinical programs. I am encouraged by not only our own progress but that of the entire sector and believe that 2012 will be an important year for Marina Biotech as well as the nucleic acid-based therapeutics field."
A month after these statements, however, Marina Biotech shuttered its Cambridge site and consolidated all R&D efforts at its headquarters in Bothell, WA. "The closing of the Cambridge site is consistent with our continued efforts to reduce our cash utilization," French explained.
Marina's collaborative efforts started last February with Debiopharm agreeing to develop and commercialize the bladder cancer program. Debiopharm will shoulder all associated R&D costs and also retain full responsibility for the development and commercialization of any resulting products. Marina could receive up to $25 million in R&D milestones plus royalties.
In December 2011, Mirna Therapeutics licensed Marina's Smarticles® technology for the delivery of miRNA mimics. It agreed to pay $63 million in total up-front fees as well as clinical and commercialization milestone payments over and above royalties on sales. Another Smarticles license arrangement came this March. ProNAi Therapeutics entered the deal to bolster development of its DNAi-based therapeutics and ProNAi has the option to select any number of gene targets. Marina could receive up to $14 million for each target in total up-front and milestone fees.
On May 8, Marina entered into an agreement with Monsanto for Marina's delivery and chemistry technologies. And on May 21, Girindus obtained the exclusive rights to develop, supply, and commercialize certain oligonucleotide constructs using Marina Biotech's conformationally restricted nucleotide (CRN) chemistry. In return Marina will receive royalties from the sale of CRN-based oligonucleotide reagents as well as a supply of cGMP material.
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text:
on November 16, 2012 - 1:17 AM
, updated November 16, 2012 at 7:58 AM
For the record, I am no fan of these Thursday night games. Actually, I hate them. Back in the days of Howard Cosell and Dandy Don Meredith, an NFL night game was a special event, a fresh and singular national sporting spectacle.
Nowadays, a night football game is just one more slot on an oversaturated TV grid. This year's expanded prime-time slate calls for each of the league's 32 teams to make one appearance on Thursday, counting the three games on Thanksgiving.
The Thursday games aren't a privilege, but a burden, a concession to TV ratings. It's tough on the coaches, even more so on players, who have only three days to rest their battered bodies after Sunday. Even starting pitchers don't work on three days' rest these days.
It's especially tough on the visiting teams, who have to travel during the short week. The record reflects it. In the last 17 Thursday night games, the home team is 13-4. The games aren't works of art, either. Six of the 10 Thursday night games this season have been decided by 13 points or more.
But the Bills certainly weren't complaining about the short turnaround after Thursday night's unsightly but vital 19-14 victory over Miami at Ralph Wilson Stadium. They weren't feeling sorry for the Dolphins, a reeling bunch who looked like a team on the back end of a day-night doubleheader.
When you've lost 11 straight prime-time games, not to mention eight straight within the division, any win is a thing of beauty. Thursday games are a pain – that is, until you win one. Then they become a trifling annoyance, a test of a team's will and perseverance.
Early in the week, the Bills said any win would do. They called it a must-win. Kyle Williams said that as soon as they took that crushing loss in New England last Sunday, their playoffs began. Why not get it started early? Getting right back on the field might be the best thing for them.
That's how they played, too. Williams said one game could be a spark for a late-season run. There's been good reason to question this team's competitive character. But they used the night game and an electrified crowd as a spark, and got a desperately needed win. It felt like a start.
"Yeah, it does," said safety Jairus Byrd, who had a fumble recovery and an interception. "We dug this hole for ourselves, so every game is a must-win. We're approaching it like that. We're kind of forgetting what was behind and saying it's a seven-game season, or whatever it was."
Now they get the reward for playing on Thursday: long rest. The Bills, now 4-6 and second in the division, have 10 days to savor their first AFC East victory in more than a year. Then they travel to Indianapolis for a game that could thrust them back into the thick of the playoff race.
The Bills began the week three games back of a playoff spot. But this win at least gives them a fighting chance, a flicker of hope in a down year in the AFC. If the Colts lose on Sunday in New England, the Bills close to within two games of Indy, their next opponent.
So unless the Colts pull the upset in Foxborough, the Bills will travel to Indy with renewed purpose. If they win that, they'll pull within one game of Indy and a playoff spot. If that scenario plays out, the Bills will be no worse than one game out of sixth place with five games to play.
The conversation would change radically at that point. Of course, the thought of this Bills team making a run is hard to fathom, after the way they played earlier in the season. But the Indy game looms large, and they have 10 days to get ready for it. A coach has to love that.
"You do," said Chan Gailey. "That's the positive of this thing. Getting ready for [a Thursday game] is tough. It's tough on the players, really more than coaches. They get a good rest now, and we get the opportunity to prepare very well for our next opponent."
This wasn't a picturesque win, by any means. The Bills have a way of making things difficult for themselves. The defense had its best game of the season. But the offense went 2 for 12 on third down, in part due to some dubious play calls by the coach. They settled for four Rian Lindell field goals and couldn't put the Dolphins away until the final minute.
But they were the better team. That's no small thing, considering that the Dolphins swept them a year ago. It was the sort of win we expected when the Bills signed Mario Williams – a low-scoring ordeal, with the defense carrying the day and the offense playing efficient, mistake-free football.
I won't get too giddy about a strong defensive effort at home against a rookie quarterback with modest weapons. Let's hold off on the hyperbole, at least until they make a similar stand on the road against Andrew Luck nine days from now.
But the defense, which was putrid for much of the season, is finally showing signs of life. They've made strides in the last three weeks. Mario Williams had a strong game. Byrd was sensational Thursday. Kyle Williams has been solid. The other Kyle – Moore – has been a welcome revelation.
Say what you will about Ryan Fitzpatrick. He struggled badly at times against Miami. His best weapon was the pass interference penalty. But he didn't turn the ball over. He got out and threw some lead blocks and played like a leader. He outplayed a rookie, Ryan Tannehill.
Leodis McKelvin has held up well at cornerback the last two weeks. He's close to a lock for the Pro Bowl as a kick returner. His 79-yard punt return in the first quarter was the play of the night, a bolt of energy and confidence for a team that was searching for belief.
It's just one game, and far too soon to attach any great significance to it. But the win breathes new life into a disappointing season and keeps alive the prospect of a meangingful December. The way the players see it, they're 1-0 on their playoff run. Who says Thursday night games are a bad thing?
"To play on such short notice, you have to rely on your adrenaline a little bit to put you over the top," said Byrd, "because you are tired. I'm going to feel it tomorrow."
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text:
RJ Sangosti/The Denver Post
Rick Fitzpatrick was mortified when a cable TV producer proposed to make a reality show starring prison inmates in the custom motorcycle program at Colorado Territorial Correctional Facility.
The inmates are laboring in a program intended to teach good work habits and viable job skills. The last thing they needed was to face off against prisoners from Nevada in a sort of �American Chopper� meets �American Gladiators� showdown.
�It would be our death sentence,� said Fitzpatrick, machine shop supervisor, who created �Old Max Choppers� to teach inmates how to build a motorcycle with parts fabricated at the prison.
This is a serious program, run in a long sliver of a shop behind the prison license-plate factory.
Fitzpatrick had men who needed to focus on turning their lives around by learning new skills and work habits, without the drama of possibly becoming cable TV celebrities � like Paul Jr. and Paul Sr. on �American Chopper.�
�I�m not here to compete with the street. I don�t care about fame. I want to make a nice product,� Fitzpatrick said. �Word of mouth goes a long way.�
The cable show never materialized, but last week the men of Old Max Choppers delivered a $24,000 custom bike to their first customer. Called �Niteshift,� the sleek black chopper is signed by the inmate designers and emblazoned with the program logo � a view of a guard tower, a skull and �Old Max Choppers� written over it. And like the inmates who made it, Niteshift has its own prison ID number � 0006.
Old Max Choppers originated from an offhanded joke.
David P. Johnson, who is weeks away from completing an 18-year prison term for burglary, said he joked to Fitzpatrick one day that they ought to start a program building choppers. A lot of people would love a bike fabricated in prison, he said.
Fitzpatrick took it seriously.
He liked the idea that inmates could learn something that could help them get a job in a garage when released from prison.
�That�s what I did before I came to prison,� Johnson said, referring to building motorcycles at a Grand Junction garage. �It had been 13 years since I�d picked up a wrench, but it�s like riding a bicycle. You never forget.�
Johnson had a hand in developing the program and even helped pick the first inmates in the program. He chose men who had welding and car-repair skills. The inmates also must have � and maintain � a good behavior record.
�I wanted to get in as soon as they added the program,� said Ken Blau, 37, of Aurora, who is serving 15 years for burglary.
Blau said the program gives him a strong incentive not to get into trouble. If he gets written up, he can�t work on the motorcycles.
But the biggest advantage is learning how to build a motorcycle.
The group is working on its sixth motorcycle. The inmates fabricate gas tanks and exhaust pipes. They recently took a flat piece of metal and fashioned a throttle linkage in a tribal design using machines in the shop. They designed the piece using computer software.
�We give it a DOC feel,� Fitzpatrick said.
The inmates must order some key parts � engines, tires � from distributor Demon�s Cycle. They build other parts, and assemble, wire and paint the bikes.
It takes about three months to build one motorcycle. The inmates are paid $1.20 a day and can work only five to six hours a day on the bikes.
Greg Ortiz, 32, of Aurora, who is serving a 20-year prison term for aggravated robbery, said he loved to build drag racing cars when he was younger. He said he is hoping to learn as much as he can in prison so that he can find a job and be a good father to his three children when he is released.
�I made a couple of mistakes. I�m trying to correct them,� Ortiz said. �This program has definitely helped me stay out of trouble.�
Johnson said when he is released from prison in less than two months, he�ll have a job waiting for him at a shop in Montrose.
Fewer than 10 inmates participate in this program, three or four in the direct assembly of the bikes. The others manufacture parts.
Fitzpatrick and his supervisor, Frank Graeber, would like to increase the number of participants, but to do so, they need to sell more motorcycles. With every other job-training programs run by the prison � including mustang and dog training, fish and egg farming, and a dairy � it must be financially self-sufficient.
�This is thinking outside the box,� Graeber said.


text:
Montgomery County, MD. DOT's ATMS Program Home Page ...
The Advanced Transportation Management System (ATMS) is composed of multiple integrated subsystems controlled and monitored from the Transportation Management Center (TMC). The ATMS is based on an open architecture that uses the latest Intelligent Transportation System (ITS) technologies to provide real-time transportation system control, monitoring, and information. The open architecture promotes the growth and the integration of systems from multiple vendors.
For any MCDOT service request or complaint, call 311
When dialing outside of the county, call 240-777-0311 or submit via their website.
For website comments or to report website problems or broken links, please email us. This email address does not handle service requests or complaints.
Director's Office · Montgomery County Department of Transportation
101 Monroe Street, 10th Floor · Rockville, Maryland 20850 · firstname.lastname@example.com
· telephone: 240-777-7170 · fax: 240-777-7178 ·


text:
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Everyone's children should have a reasonable shot at a good, four-year college education.
That's a simple proposition, but one that we here in the Town of Mount Pleasant take to heart. That's why our Town Council feels it is appropriate to extend a formal invitation to Francis Marion University to establish a satellite campus in our town.
Constituents have been telling us for years how tough it is to find and pay for a quality baccalaureate education around here. Issues of both affordability and accessibility block the way. We decided that we needed to take a look at a school that local legislators have told us was doing a good job on both accessibility and affordability. If the folks at FMU accept our offer — as befits a well-run institution, they are taking time to research and consider this decision — we think it will be a great fit and a real boon for kids across the tri-county area.
Not everyone agrees with our idea, including the editorial board of The Post and Courier, which took issue with it in a recent opinion piece. They just couldn't understand our thinking and suggested we were moving too fast towards an end they thought unnecessary.
They are entitled to their opinion, but here on the ground, the facts have led us to a different conclusion. Thousands of tri-county kids who want and deserve a good, four-year college degree just aren't being served.
The public and private colleges in the area just aren't willing, or perhaps able, to do what's required to meet the needs of one of the fastest-growing parts of South Carolina. Francis Marion can be part of the solution. Our neighbors from Florence have a long and laudable record of educating South Carolinians of all stripes and types. That would make them an excellent fit — if they agree to come.
That's the nut of our idea, but we understand that it represents innovative, out-of-the-box thinking and consequently may be hard for some to digest. That's just like the out-of-the-box thinking the town had when we purchased the old Bassett Furniture store and asked Trident Technical College to open a campus for our citizens. We believe that anyone armed with all the facts will not suffer dyspepsia for long, however. Let me provide some details, and some insights into our thought process:
• The need. This really does seem very clear to us. The most affordable educational option for many families in our area is to attend a school that's close to home for all or part of their baccalaureate studies. But the Charleston area's four-year institutions are either too narrowly focused, too expensive, or headed down a path that precludes serving a wide range of South Carolina students.
The College of Charleston would be the most likely candidate to meet this need, but it is, as best we can tell, moving on a different track, towards a new type of institution, through the recruitment of more out-of-state students. According to S.C. Commission on Higher Education statistics, nearly half of the College of Charleston's undergraduate student body is from out-of-state, a figure that has been climbing steadily for several decades. That's led to a college that looks less like South Carolina — just 6 percent of the undergraduate population is African-American — and has fewer slots for South Carolinians and tri-county area students in particular.
In fact, just 13 percent — 13 percent! — of C of C's 2012-13 freshman class (the most recent for which data are available) is from this area. That's unlikely to change, given C of C's trajectory and its self-imposed 10,000-student enrollment cap.
Given this vacuum, proprietary, for-profit colleges have descended on the area with a vengeance in recent years. Some may view that as a sign of an educational glut and service duplication. We see it as yet another sign of unmet need. The proprietary schools exist to make a profit. They're here because of a recognized need. That's fine. It's a free country. But their presence doesn't change the picture. Those schools are expensive and they just don't offer the educational quality or stability that our constituents are seeking.
Francis Marion University does.
• The fit. After considering a number of schools, Mount Pleasant chose to invite FMU because of its long history of serving South Carolinians. More than 95 percent of the student body at FMU is from South Carolina, and its core mission has always been to educate a broad array of students from this state.
In recent years, FMU has also shown itself to be an innovative and nimble institution, which will certainly be useful in a dynamic region like ours. For instance, FMU has recently added new, career-oriented programs in healthcare and engineering. Both were implemented at the behest of local business and industry leaders. We're just taking our cue from those folks, following their example. FMU is a school that's responsive and gets things done.
• The program. Details remain to be worked out, but I can tell you today that FMU's satellite campus, if put in place, would be a limited, fiscally prudent campus offering a few, specifically targeted majors. The school's obvious expertise in health care instruction — FMU's nursing grads regularly post the state's top mark on the licensure tests — suggests one likely area of study. Others will be developed.
All will be based on a careful assessment of local needs and abilities. The campus will be quite modest. Mount Pleasant has agreed to find a suitable building for the college, and to help maintain it. We're not looking for a Taj Mahal. Just a good, safe building where we can invest in our children's future — which, of course, is what this is all about. We're taking a bold step in seeking what's best for the families that make up our community.
We eagerly await Francis Marion University's decision.
Billy Swails is mayor of the Town of Mount Pleasant. This column was also signed by council members Thomasena Stokes-Marshall, Linda Page, Ken Glasson, Elton Carrier, John Burn, Chris Nickels, Chris O'Neal and Craig Rhyne.


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Hello, Writers! Please see below for the Fall 2016 schedule. Opening Day is Monday, September 12th.
Mission Statement
The Writing Center strives to serve all undergraduate student writers on the campus of Gonzaga University by providing free, non-credit learning support. Student writers of all abilities are welcome to visit the Writing Center as they produce writing for audiences in curricular, co-curricular, and pre-professional settings. The Writing Center's tutoring philosophy entails treating every student with respect and approaching each tutoring session as an opportunity for critical, rhetorically-sensitive dialogue. This dialogue usually addresses students' writing processes as well as their actual writing projects.
Overview of Services
Students can visit the Writing Center at any stage of their writing project, including brainstorming, drafting, revising, and editing. While the Writing Center is not an copy editing service, tutors will help writers develop self-editing strategies. Students may come to the Writing Center by their own choice and by instructor referral. With advance request by faculty, group tutoring is a possible additional service, as are in-class orientation sessions (5-minutes or longer). The Writing Center also welcomes faculty to schedule class visits to the Writing Center, to learn more about the services provided by the tutoring staff. At present, the Writing Center does not offer online tutoring, but writers are encouraged to take advantage of the resources listed on this website.
You'll find the Writing Center on the first floor of the Foley Center Library. Come in for a visit!
Hours for the Fall 2016 semester are listed below. Opening Day will be Monday, September 12. The Writing Center will be closed for all holidays holiday weekends. Thank you.
|10 a.m. to 8 p.m.
Are you a Gonzaga student interested in applying for a tutoring position? If so, please submit the Writing Tutor Application form listed in the left-hand navigation bar. If you have questions related to the Writing Center, please contact Dr. Eliason, the Writing Center Director, at email@example.com. Thank you.
Dr. John Eliason
Director of Composition and the Writing Center
Phone: (509) 313-6717
Email: firstname.lastname@example.com


text:
Latest Posts
June 30, 2013June 30, 2013 | 3:58 am The US Headline: Kerry squeezes in more talks at end of Mideast mission To Read: Max Boot and Michael Doran argue that this is the time for the US to be as dirty as necessary and... read on
Rosner's Torah-Talk: Parashat Pinchas with Rabbi Roberto ArbibJune 28, 2013 | 8:08 am Our special guest today is Rabbi Roberto Arbib, founder and Educational Director of Tel Aviv's Neve Schechter Center. Rabbi Arbib made Aliya in 1959 from Italy. In 1978 he began... read on
June 28, 2013June 28, 2013 | 3:25 am The US Headline: Retired U.S. General Is Focus of Inquiry Over Iran Leak To Read: Robert Kaplan writes about how post cold war US Presidents lack the authority their cold war... read on
The Rosner-Pinto Exchange, Part 2: Do Diaspora Jews Have a Say on the Conflict?June 27, 2013 | 8:24 am Dr. Diana Pinto is a French-Italian Intellectual Historian and policy analyst living in Paris. Dr. Pinto, who received her PhD from Harvard University, is a former senior fellow and... read on
June 27, 2013June 27, 2013 | 3:13 am The US Headline: Kerry resumes Israeli-Palestinian peace bid To Read: Aaron David Miller examines John ("the Lone Ranger") Kerry's great Middle East gamble- This week, the... read on
June 26, 2013June 26, 2013 | 3:42 am The US Headline: Hopes for Syria Talks Hinge on Kerry-Lavrov Meeting To Read: Does consistently failing to help others make the US a 'failed State'? David Rothkopf muses on the... read on
Apparently, Jewish Journalism is a Confusing BusinessJune 25, 2013 | 8:52 am Alan Abbey, director of media and Internet services at the Shalom Hartman Institute, spoke recently about a new report released by the Institute about "Jewish media." At the outset, he... read on
June 25, 2013June 25, 2013 | 3:24 am The US Headline: For Kerry, little new traction as yet another visit to Israel awaits To Read: Michael Rubin believes that the US' efforts should be focused on Iran, not... read on
The Rosner-Golinkin Exchange, Part 1: Can Women Wear Tefillin According to the Talmud?June 24, 2013 | 8:02 am Rabbi Prof. David Golinkin is President and Professor of Jewish Law at the Schechter Institute of Jewish Studies in Jerusalem. For twenty years he served as Chair of the Va'ad Halakhah... read on
June 24, 2013June 24, 2013 | 3:32 am The US Headline: Russia defiant as U.S. raises pressure over Snowden To Read: Leon Hadar criticizes the Obama administration's murky representation of its motives in... read on
Israel Factor: So How's Obama Doing on Iran?June 23, 2013 | 7:17 am Three weeks in Middle East news are an eternity. Imagine that three weeks ago, the Obama administration was still hesitant to admit the Syrians used chemical weapons and was still... read on
June 23, 2013June 23, 2013 | 3:59 am The US Headline: 'PM won't ask US for exemption from defense cuts' To Read: Law Professor and former Senior State Department advisor Rosa Brooks examines the legality of a possible... read on
Rosner's Torah-Talk: Parashat Balak with Rabbi Elliot DorffJune 21, 2013 | 5:55 am Our special guest today is Rabbi Elliot Dorff, Rector and Professor of Philosophy at American Jewish University. Rabbi Dorff was ordained by the Jewish theological Seminary in 1970 and... read on
June 21, 2013June 21, 2013 | 3:30 am The US Headline: Kerry to Defend Syria Policy to Middle East Allies To Read: TNR's John B. Judis finds it curious that the most vocal objectors to a US intervention in Syria come... read on
On the Austrian Troops AffairJune 20, 2013 | 7:52 am Some house cleaning- Last week I wrote an article about Austria pulling its forces from the Golan Heights. Read it in full here, or the following two short paragraphs: The... read on
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text: Kevin has been a direct mail fundraiser since 1989. He has worked for the Richard Norman Company since 1994 and is currently it's Chief Operating Officer. Kevin's long list of current and former clients includes organizations such as The American Conservative Union, Citizens United, Freedom Alliance, Media Research Center, the NRA, Senate Conservatives Fund, Sixty Plus, Tea Party Patriots, Congressman Steve King, and Senator Pat Toomey. Before working for the Richard Norman Company he worked for Viguerie & Associates, a congressional campaign, and Citizens United. He also currently serves as the Treasurer of Citizens United PAC and the Virginia Society for Human Life. He has also volunteered to help many local candidates and organizations with their direct mail. He resides in Bristow, VA with his wife, Michele and their two kids Blake and Shannon.


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City Hospital rates scheduled to increase
January 12, 2013
MARTINSBURG — Continuing an annual trend, City Hospital was recently approved for a benchmark increase to its rates for 2013. Effective Jan. 1, the rates at City Hospital rose by 4....
I sure wish patient care and cleanliness of the hospital increases by 4.58% too. I go to Winchester hospital before City hospital anyday.
1 Agrees | 3 Disagrees | Report Abuse »
A relative was in need of an ER for non-life threatening illness a month or two ago. We drove by City Hospital to get to a decent ER.
1 Agrees | 1 Disagrees | Report Abuse »
Sorry guys, but City Hospital has made such great strides in the last 10 years. You need to stop with the old rhetoric. Go ahead and drive to Winchester, makes more room for the rest of us who need it!
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Showing 3 of 3 comments


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Even as Altoona Regional Health System explores options for partnership at the macro level, a doctor affiliated with the hospital is expanding at the micro level.
On Thursday, Zane Gates, founder of Partnering for Health Services, a free clinic in Altoona, will hold the grand opening for a clinic in Marion Center, affiliated with Indiana Regional Medical Center, according to a news release.
It's the first time Gates and partner Patrick Reilly, a Buffalo-based insurance broker, have taken Gates' model outside Altoona, but it won't be the last, they hope.
"Our goal is to get it statewide and then nationally," said Reilly, co-founder of the new clinic, Empower 3 Center for Health. "We are currently speaking with several very interested hospitals locally and in Philadelphia."
The Gates model focuses on the working poor: those who earn too much to qualify for Medicaid but not enough to buy standard private insurance.
Subscribers buy full coverage insurance for $99 a month, with a requirement that they use the new clinic or the Indiana hospital.
The partner hospital benefits by reduction of uncompensated emergency room visits.
The clinic model calls for paid and volunteer staff and drugs obtained for free because they're approaching their expiration dates.
The program stresses preventive care and reduction of risk by changing individual behavior.
The formation of the new company, with Gates as majority shareholder and local investor help, represents a new strategy for Gates and Reilly.
"We have been running around for three years telling everyone this model works, but [have gotten] no government support just yet," Reilly said. "We decided to take our argument right to the community hospitals that are getting financially hammered in the emergency rooms by the growing uninsured."
There's room for the clinics despite changes wrought by Obamacare, whose goals include providing insurance for everyone, Reilly said.
"Lots of folks will still need serious help," he said.
The new private company formed by Gates and Reilly isn't affiliated with Altoona Regional.
Mirror Staff Writer William Kibler is at 949-7038.


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on March 26, 2013 - 4:22 PM
BATAVIA – With only one week left in its fiscal year the City Council Monday got around to approving a $23 million budget that shifts garbage collection costs to individual property owners.
The budget lowers the per $1,000 value tax rate by $1.41 but as of June 1, residents will pay to have trash and recyclables picked up. That's a boon to businesses that hire private collection services but also pay through property levies.
The vote to end trash pickups passed 8-1 with Ward 4 Councilman Pier Cipollone claiming the change is "not in the best interest of the citizens."
The decision not to renew a five-year contract for weekly collection with Genesee ARC prompted weeks of protests. The city had paid ARC for the service for nearly three decades. This year for the first time the service was put up to bids and ARC was far from the lowest.
City Manager Jason R. Molino said letters will be sent to all property owners this week explaining the change in collections and listing vendors to take over the service. ARC will be among them. The cost to residents will likely erase the savings from a lower property tax rate, estimated at $125 to $150.
The Council in "cleaning up old business" – some of it a month old – voted against awarding a five-year pact to Allied Waste Management as well as the purchase of wheeled totes that were to be used by a new hauler.
The budget resolutions included $5 million to be raised through local taxation, a small increase in water rates and fees, a 1.5 percent pay raise for non-union and part-time employees, and a realignment of some Police Department personnel, including hiring an assistant chief.
The spending plan also includes funding for the Batavia Development Corp. for two years with $125,000 for its revolving loan fund. The money is expected to come from proceeds from the Batavia Downs Casino's video lottery terminals. Another $45,000 will be taken from a contingency fund to support a two-year commitment for residential and business development along with job growth strategies.


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EUGENE, Ore. - As Keloni Kamalani signed footballs, posters, wristbands, hats, helmets, T-shirts, skin and whatever else was put in front of him a week ago on a sun-drenched day at Autzen Stadium, he was thinking about just how far he has come.
"It just makes me appreciate the fact that I have got good people who helped me get here," Kamalani said moments after Oregon's football fan day. "And if it wasn't for them, I wouldn't be here - people like my father (David), my mother (Shawndelle), I can't forget about them."
A few minutes later, Kamalani entered the third-ranked Ducks' locker room by flashing his thumb print on an entry screen - before graduating from Kamehameha Schools Maui in 2009, it would have been hard to imagine him at Oregon's state-of-the-art athletic complex.
Article Photos
Keloni Kamalani, shown at Oregon's fan day on Saturday, played in five games last season.
The Maui News / ROBERT COLLIAS photo
Injuries limited his impact as a Warrior to the point where he had to walk on to the Ducks, but he now owns two Pac-10 championship rings, and last season played in five games, including the national title-game loss to Auburn.
Kamalani, who made every travel squad last year, is now seeing significant time with the second-team linebackers and is expected to be a starter on all special teams, meaning he should be on the field for the first play - kickoff return or receive - when Oregon opens its season today at Cowboys Stadium against No. 4 Louisiana State.
Kamalani is one of six Maui Interscholastic League graduates to play for a Pac-12 football team, and perhaps none have come so far so fast. He was a fifth-stringer at the beginning of spring drills, limited to noncontact work due to shoulder surgery after last season.
"It was always a dream," he said. "You think about it, you pray about it. I can only thank Jesus that I am here right now."
Kamalani plays strong-side linebacker, a position that does not usually come to a second-year player, walk-on or not, who is 5-foot-11 and 215 pounds.
"It is a lot of time and commitment, it is almost like a job," Kamalani said. "We are here almost all day every day. I just know that my opportunity is going to come and when it arrives I have to be ready and I do that by preparing myself."
All the effort seems to be paying off.
"Probably the most noticeable area of improvement for him has been understanding our defensive concepts - he has done a tremendous job there," said Ducks linebackers coach Don Pellum. "To his credit, you can tell that he has been doing the study and the work because the evidence is on the field."
Pellum was himself an undersized linebacker for Oregon, and has been at the school for more than 20 years.
"He just keeps on telling me I need to show up," Kamalani said. "That is what I have been doing. That is the only way I am going to get myself out there, get that scholarship, get that playing time."
Kamalani has a 365-pound bench press, 465-pound squat and 330-pound power clean, plus 4.5-second speed in the 40-yard dash.
Pellum laughed when asked if Kamalani reminds him of himself on the field.
"I wasn't as strong, no, no, not at all," Pellum said. "Maybe in one area - toughness. He is a tough dude."
Since Oregon's 22-19 loss on the final play to Auburn in January, Kamalani has not cut his hair, going from a tight crop to six-inch flowing locks with dark roots and blond ends.
"New look, new style, playing harder, playing faster," he said.
Pellum said the new 'do has grown on him, at least a bit.
"I have grown to not be shocked by it," he said. "He has got that golden hair with the tan and the nice tats. It is starting to look OK."
Kamalani has also changed his uniform number from 57 to 43 in honor of the Pittsburgh Steelers' Troy Polamalu and Cleveland Browns' Kaluka Maiava - a former Baldwin standout who wore 43 at Southern California before becoming the first MIL graduate to be drafted by an NFL team, in 2009.
"We are tougher than most people think, we produce some pretty good athletes," Kamalani said of the MIL. "I just want to follow in the footsteps of Kaluka."
With his left arm fully covered in Polynesian-style tattoos to go along with his new hair, he is asked where is from all the time, as one youngster did at fan day.
"People say some weird stuff to me," he said. "They think we still live in shacks and are from Gilligan's Island."
* Robert Collias is at email@example.com.
6 a.m.-Kent St. at Alabama, KFVE
6 a.m.-Akron at Ohio St., ESPN
6 a.m.-Utah St. at Auburn, ESPN2
6 a.m.-Northwestern at Boston College, ESPNU
6 a.m.-Miami (Ohio) at Missouri, FSW
9:30 a.m.-Minnesota at Southern Cal, ABC
9:30 a.m.-S. Florida at Notre Dame, NBC
9:30 a.m.-W. Michigan at Michigan, ESPN2
9:30 a.m.-Louisiana-Monroe at Florida St., ESPNU
9:30 a.m.-James Madison at North Carolina, FSW
9:30 a.m.-UCLA at Houston, FSWP
9:30 a.m.-Delaware at Navy, CBSSN
10:45 a.m.-BYU at Mississippi, ESPN
1 p.m.-Florida Atlantic at Florida, ESPNU
1 p.m.-E. Carolina vs. South Carolina, FSWP
2 p.m.-LSU vs. Oregon, ABC
2 p.m.-Boise St. at Georgia, ESPN
2 p.m.-Tulsa at Oklahoma, FX
4 p.m.-Louisiana Tech at S. Mississippi, FSW
4:15 p.m.-Colorado at Hawaii, ESPN2
4:30 p.m.-Grambling St. at Alcorn St., ESPNU
6 a.m.-Bethune-Cookman vs. Prairie View A&M, ESPN
9:30 a.m.-Marshall at West Virginia, ESPN
1:30 p.m.-SMU at Texas A&M, FSWP
2 p.m.-Miami at Maryland, ESPN


text:
Author(s): J. F. San-Miguel, O. Sezer, D. S. Siegel, A. Guenther, J. Blade, I. W. Prosser, B. Bengoudifa, M. Klebsattel, P. M. Bourquelot, K. C. Anderson
Background: Panobinostat (PAN; LBH589) is a potent pan-deacetylase inhibitor (pan-DACi) that disrupts aggresome and HSP90 function via inhibition of HDAC6, promoting cytotoxic misfolded protein aggregates and MM cell death. Combination of PAN with the proteasome inhibitor bortezomib (BTZ) demonstrated synergistic cytotoxicity in preclinical studies.
Methods: Pts with Rel or Rel and Ref MM receive PAN (po thrice weekly) and BTZ (iv days 1, 4, 8, 11) on a 21-day cycle to establish the MTD of the combination.
Results: Per October 9, 2009, cutoff, 38 pts were treated in 5 cohorts (Co) (Table): median age 62 (range 46-78), median 2 prior therapies (range 1-7), including stem cell transplant (n=30) and BTZ (n=22; 13 pts BTZ-refractory). No dose-limiting toxicities (DLTs) occurred in Co 1 or 3, 1 DLT in Co 2 (neutropenia [NP]), 4 DLTs in Co 4 (2 thrombocytopenia [TCP], 1 pneumonia/TCP/NP, 1 fatigue), and 1 DLT in Co 5 (TCP/asthenia/dizziness). Hematologic adverse events (AEs) included Gr 3/4 TCP (n=30), NP (n=23), and anemia (n=6). Other AEs included diarrhea (n=23), nausea (n=18), pyrexia (n=17), fatigue (n=16), and asthenia (n=13). There has been no Gr 3/4 peripheral neuropathy and no treatment-related death. Responses were observed in 26/38 pts (68%) across all Co (Table). Notably, responses were also seen in 8/13 (62%) BTZ-refractory pts. Management of AEs, including TCP, permitted by dose reduction or interruption, allowed for longer time on study in Co 3, which also had the most favorable efficacy profile (7/8 pts responded). These results support the use of Co 3 dose levels in subsequent trials.
Conclusions: The combination of oral PAN and BTZ has a predictable and manageable safety profile with promising activity in pts with Rel or Rel and Ref MM, including MM refractory to prior BTZ. Enrollment at 20 mg PAN + 1.3 mg/m2 BTZ is ongoing to determine MTD. A modified dose schedule is now introduced in phase II and III trials with this combination in order to maximize therapy duration.