text: SHOPPING FROM THE US?Visit our US website to receive a free delivery option and reduced delivery ratesStay on this SiteShop the US Site HomeTabletAppleiPad 3Snugg iPad 3 Ultra Thin Smart Case in Black Snugg iPad 3 Ultra Thin Smart Case in Black 5 (4) prev next Roll over the image to zoom and enlarge $34.99 Out of Stock Change your selected model iPad 2 iPad 3 iPad 4 iPad mini Which model do I have? Select from 1 different colors BlackOut Of Stock Or buy through one of our official retail partners: Features Full Details Delivery & Returns Model Guide Features Product Features Black, ultra-thin, hot pressed PU leather case for the iPad 3.2 Stand positions.Cut outs for cameras, buttons and ports.Automatic Sleep/Wake function. Tech Spec Height: 24.4 cm Width: 18.6 cm Depth: 1 cm Weight: 0.204 kg Materials Used Hot pressed PU leather exteriorSoft nubuck fibre interiorHard PC edges and clip on rearMagnetic close contact cover Full Details The Snugg iPad 3 Ultra-Thin Case is sleek, classy and adds hardly any bulk to the iPad. This new design is extremely lightweight. Made from Hot Pressed, PU Leather whch is smooth, highly resistant to wear and tear, grease and oil. The hard, TPU back cover provides support and extra protection once the iPad is correctly clipped in, perfect for braving the perils of the morning commute. The inside is lined with a high quality microfiber that is soft to the touch and wipe clean. We chose this material to ensure your iPad remains scratch free when inside the case and because of the premium, luxury feeling it provides when you handle your iPad. This Ultra-Thin, case folds quickly and easily into a triangular stand to support your iPad at two comfortable viewing angles. The first is perfect for typing. The second, ideal for watching films. Both reduce neck strain and discomfort. As if all of these features weren't enough, this spectacular case even includes the sleep/wake function, just like a smart case! There's no need to remove your iPad from its case should you wish to hook up your existing gadgets. This case has been designed to allow access to all ports and connection points so inserting headphones, external keyboards and portable iPad chargers is never an issue. As with all of our iPad cases we provide The Snugg Promise: The Perfect ''Snugg'' Fit; The Finest Materials and High Quality Craftsmanship. That's why we proudly press The Snugg logo into all of our cases. We continue to innovate and evolve our cases to meet your needs and to protect your iPad from the trails of everyday life, whilst throwing in quality materials and style for good measure. So why wait? Buy yours today! MPN: B0089YBO2W EAN: 5060248970904 Delivery & Returns Delivery Options (to Canada) Postal Delivery (5 Days) - FREE Courier Delivery (2 Days) - $10.00 Canada Returns If you are not completely satisfied with our goods and services you have the right to return the item up to 28 days after receipt of your product and receive a full refund for the goods. If the goods have arrived to you in a damaged state or there was an error on our behalf please contact us at email@example.com for your free returns label. However if you have simply changed your mind, postage will not be provided and you will need to return the goods to us in a good condition. Full details of how to return your item are on the reverse of the packing slip included with your order. If your order was placed before 22nd April 2013 than please contact firstname.lastname@example.com for further instructions. Model Guide iPad Size Guide Turn your iPad over. On the back, near the bottom, the Model Number will be printed in tiny letters. Reference the model numbers below to determine your iPad version: iPad 1: A1219 or A1337 iPad 2: A1395, A1396 or A1397 iPad 3: A1416, A1430 or A1403 iPad 4: A1458, A1459 or A1460 iPad Air: A1474 or A1475 iPad Air 2: A1566 (Wi-Fi) or A1567 iPad mini: A1432, A1454 or A1455 iPad mini with Retina: A1489 or A1490 iPad mini 3: A1599 or A1600 Customer Reviews 5Jeanette5th May 2015 21:05:52Woks better than my old apple cover, that never really remained elevated when the back folds over. 5Marion2nd February 2015 11:02:30I bought my first Snugg Smart case for my I-Pad 3 awhile back. I loved the way it fit like its name said----snuggly. But recently my I-Pad fell to the floor and when I retrieved it, I found the one corner chipped off the Smart Case. The I-Pad had no damage but the case no longer stayed on theI-Pad. I purchased another Smart Case for it and now I have excellent coverage again. 5ward16th January 2015 21:01:25Great value, great product. Don't know why you would buy from anyone else. 5Barbara12th December 2014 16:12:58Works great. I have the single, flip over magnetic cover from Apple and it will come detached on occasion. The Snugg case also seems to hold in the "stand position" and is not "flimsy". Available Offers For This Product Snugg Pack of 2 iPad 3 High Transparency Screen Protectors $9.99 Total Price: $40.48 Save $4.50 Plus Free Delivery Snugg Pack of 2 iPad 3 Anti bacterial and Anti fingerprint Screen Protectors $9.99 Total Price: $40.48 Save $4.50 Plus Free Delivery Snugg 2 in 1 Silver Stylus and Writing Pen $14.99 Total Price: $47.48 Save $2.50 Plus Free Delivery Snugg 2 in 1 Red Stylus and Writing Pen $14.99 Total Price: $47.48 Save $2.50 Plus Free Delivery Snugg 2 in 1 Black Stylus and Writing Pen $14.99 Total Price: $47.48 Save $2.50 Plus Free Delivery Snugg iPhone 5 Leather Pouch Case in Black $19.99 Total Price: $52.23 Save $2.75 Plus Free Delivery Snugg Power 8Ah Lightning Fast Portable Charger $109.99 Total Price: $137.73 Save $7.25 Plus Free Delivery


text:
Top Definition
One who goes out of their way to go to a different 'common' bathroom than normal due to how nasty the deposit will be.
Dude, do not use the bathroom in accounting. I had to be a toilet tourist after the trip to the all you can eat chinese buffet.
de JimBrewSki 22 Mai 2011
Trending Now
Can you define these popular missing words?

subset: commoncrawl


text:
The ultimate truth, what it all comes down to. Pessimistic (Albeit true) laws of the outcome of things in the universe.
If something can go wrong, it will.
von AvengerXP 4. September 2003
murphys law has many variations, including, "the reason why a day goes bad: (insert original murphy's law here) and then you hit chem class with people that yell at you for helping because they dont understand other people asked that person for help, and then you leave the class and continue to encounter other ridiculous absurdities, similar to symetrically shaped objects, where one side is specifically labeled -this side up- because sillyness is at work in the word ridiculing all that is sane and good "
Mr.brian bills: chemistry student and day experiencer: who also gallantly feels the need to apologize when he has a bad day
von the all knowing one 7. Januar 2005
the law in nature that makes the B's prone to seeing Ken everywhere we go. Ken is everywhere and we always run into him at horrible times. B usually runs away screaming "MURPHYS LAW!!"
-aka- Ken's Law
-aka- Ken's Law
after a long hard workout, who do we see?? but ken walking to his sweet car
-Murphy's Law
-Murphy's Law
von Bitch 7. Dezember 2004
commonly called 'sods law'
"thats sods law for you!"
von Matt 30. September 2003
Everything that could possibly go wrong will. The only reason that this is sometimes true is because everybody that believes it has a really pessimistic view on life, and if you have a positive attitude good things will happen.
I called a girl up and asked her out on a date. I got diarrhea, I lost my job, my car crashed, I was 2 hours late, and when I got there she had already left on a date with another guy. So I came home, told my hot roommate, and we ended up fucking all night long.
von Buttfucked 7. September 2003
the worst always occurs at the most inopportune time
I got in a car wreck and just like murphy's law said I also lost my job.
von Anonymous 4. September 2003
The title of Murphy Lee's album.
Murphy Lee's new shiz Murphy's Law is off da heez fo sheez.
von Anonymous 9. Oktober 2003


text:
Submit News
Tesla CEO Elon Musk Willing to Take Auto Dealer Fight to Federal Level
Tiffany Kaiser
April 16, 2013 12:13 PM
comment(s) - last by
Apr 20
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He'll either lobby Congress for legislation or file a federal lawsuit
Tesla CEO Elon Musk is determined to win the fight against auto dealers and sell his company's vehicles directly to customers, but if he doesn't succeed at the state level, he's willing to make it a federal case.
"If we're seeing nonstop battles at the state level, rather than fight 20 different state battles, I'd rather fight one federal battle," said Musk.
According to Musk, he will likely take one of two approaches if it comes down to a federal matter. He will either lobby Congress to pass legislation for the direct sales of EVs made by startup companies like Tesla (and tie it to an energy or transportation bill) or file a federal lawsuit to fight the state restrictions as unconstitutional violations of interstate commerce.
However, The National Automobile Dealers Association (NADA) said it will continue to defend franchise and consumer laws in the states.
"NADA will vigorously defend the franchise system," said David Westcott, chairman of the National Automobile Dealers Association. "A better option for Mr. Musk is to take advantage of the dealer network that already exists."
Musk has been
pushing support fo
r a recent bill
in Texas, called
House Bill 3351. This would allow distributors and manufacturers of electric vehicles (EVs) only to sell directly to customers without the use of dealerships.
He has gone as far as offering to
build a second manufacturing plant
in Texas, and is even trying to appeal to Texas consumers by discussing a design for an electric pickup truck that would be stronger than any current gasoline truck.
In addition to Texas, Musk has had issues persuading other U.S. states to allow the auto startup to sell its cars directly. Some of its problem states include Colorado, Massachusetts, Minnesota, New York and Virginia.
Musk could have a huge fight ahead, though. NADA said that 48 states have some sort of restricition on factory-owned dealerships. Musk went on to say that about 20 of those have restrictions that would make his business model difficult while about six others have restrictions that would make it extremely difficult.
Musk has called the new Texas bill (and this overall business model of selling directly) a "life or death" situation for startups like Tesla.
"For us this is life or death," said Musk. "If we can't go direct we will not be able to sell cars."
In the past, Musk has said that he's open to a dealership model at some point when sales increase, since dealerships do promote competition and keep prices down. But at a startup level, he said this type of model isn't the best route.
Tesla currently sells about 10,000 cars in North America, where about 1,500-2,000 are sold in Texas.
Tesla is shipping over 500 Model S EVs weekly, and recently reported that
the company is now profitable
thanks to the Model S exceeding sales targets. Tesla Model S sales reached 4,750, which topped the sales outlook of 4,500 posted in the February shareholder letter.
In addition, the automaker is partnering with Wells Fargo and U.S. Bank to offer customers more financing options for Tesla's vehicles.
Automotive News
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(1 Hidden)
RE: Pretty pathetic
I can see some of the arguments here, but let's not start off with false premises.
Car dealership DO NOT exist for the sole purpose of extorting money from you.
The serve to get products from the manufacturer to the consumer, to service the vehicles according to the manufacturers specification, to assure they adhere and keep adhering to the environmental guidelines, to handle factory recalls, and to repair defective or damaged vehicles in a timely manner with the appropriate parts and tools. Agreed some are better at this than others, but it is what they are for.
Let's also examine Mr. Musk's statement. He claims that, if his vehicles are to be soled through dealer franchises, they become a losing proposition.
I can, however, not determine from the article why he deems this to be so. I can guess at the reason : his EV's are so expensive to produce at this time that adding a dealer overhead would make them so expensive they would become unsellable. This may be true at this time. If you make 500 cars a month, and if we make this -for the sake of argument- 10 cars per US state (I said : for the sake of argument, didn't I ?) and he would have to commission 5 dealerships per state, how many cars would they effectively be able to service every month ? Do the math. It can't possibly work. Even if they had enough reserves to to tie them over for one year they'd go bust the second.
Even if he used existing dealers, they would have to invest in training, tools, dedicated workstations, spare parts inventory, etc, for what ? 4 services a month whey they have a really busy month ? Again, do the math.
So how does Mr. Musk envision this ? Or did he 'forget'? It's called 'the cost of doing business'. Surely he budgeted for this ?
Or does Mr. Musk have other reasons for making his statement ? I would like to know them.
(1 Hidden)
RE: Pretty pathetic
Landiepete I want to say thank you! You have kept a level head and shared some very good points to be considered. I usually hear a lot of arguments against Musk on this topic. But most can say nothing relavent/convincing besides just saying he is wrong, with nothing of substance to back it up. So thank you! But I do question a few things you wrote above…. Why wouldn't Tesla be able to offer the services you mention that the dealers can offer, like service to the manufacturers' specification, assure they adhere to environmental guidelines, handle factory recalls, repair defective or damaged vehicles in a timely manner with the appropriate parts and tools? Tesla has a service team, which at this time, comes to your home and provides most of these services at your home. And he is trying to change the laws so he will be allowed to have service centers that can do warrenty work to the spects you mention. That is one of the things the curent laws restrict him from being able to do.
Musk is trying to do this ("making his statement") because at this point most dealerships do not favor EVs. And so for that reason alone they would not try to sell them to customors. Where is their incentive to sell an EV over an ICE? It certainly isn't in the fees to be charged at a later time from their service centers, which won't be needed as offten with EVs.
Please watch…
If links can't be showen please search for the video entiteled "Elon Musk: The TT Interview". I believe he addresses a lot of your ligitiment concern within this short video.
RE: Pretty pathetic
I've just saw the clip you posted, thanks. Unfortunately, I still don't see a valid argument from a consumer point of view.
Apart from problems that will arise from his proposal (when dus a start-up loose it's start-up status ? Even worse, how does a start-up that becomes a no-startup-any-longer suddenly afford a state-wide dealer network ? Aren't they just postponing the problem ?) I'm trying to imagine what would happen if my Tesla broke down (I'm actually considering purchasing one, so it's not too far from the realm of the practical).
Imagine this : you're driving along minding your own business, and your car breaks down. You pull up on the hard shoulder, and ring the AA or your insurance. A while later a truck arrives. A guy opens your hood, can't fix it, and tows your vehicle to the nearest dealership where you are handed the keys to a loaner while they fix your car. Two days later you get a phone call to pick up your car, drive over, hand them the keys to the loaner, pay yur bill (OR NOT)and you're on your merry way.
Now, same deal, your Tesla breaks down. You call the AA. No you don't. They know nothing about EV's (yet). You call Tesla. How many intervention units do you have in your state ? Two ? Four ? They tell you the nearest one is 150 miles away and has two more appointments that day. They send a tow truck. The car is sent back to your home, because there's no dealers. The day after the Tesla truck arrives at your door. You've taken the day off, because they couldn't tell you what time they would be arriving. But you weren't going anywhere anyway, since the Tesla's dead. The tech can't fix it, it needs to go back to the factory ? You get a voucher for the rental (the tow guy couldn't give you that, because 'Tesla has to verify your vehicle is indeed unfixable in situ'. You ALWAYS have to wait for the Tesla truck. Reverse thing happens when your car is eventually fixed.
I'm just pulling this out of my behind, of course, but I haven't heard Mr. Musk elaborate on how he will handle these situations. And as long as he doesn't I'm sceptical.
"I'd be pissed too, but you didn't have to go all Minority Report on his ass!" -- Jon Stewart on police raiding Gizmodo editor Jason Chen's home
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text:
Source: Businessweek
quote: The GeoSpring in particular, Nolan says, has "a lot of copper tubing in the top." Assembly-line workers "have to route the tubes, and they have to braze them—weld them—to seal the joints. How that tubing is designed really affects how hard or easy it is to solder the joints. And how hard or easy it is to do the soldering affects the quality, of course. And the quality of those welds is literally the quality of the hot-water heater." Although the GeoSpring had been conceived, designed, marketed, and managed from Louisville, it was made in China, and, Nolan says, "We really had zero communications into the assembly line there."To get ready to make the GeoSpring at Appliance Park, in January 2010 GE set up a space on the factory floor of Building 2 to design the new assembly line. No products had been manufactured in Building 2 since 1998. An old GE range assembly line still stood there; after a feud with union workers, that line had been shut down so abruptly that the GeoSpring team found finished oven doors still hanging from conveyors 30 feet overhead. The GeoSpring project had a more collegial tone. The "big room" had design engineers assigned to it, but also manufacturing engineers, line workers, staff from marketing and sales—no management-labor friction, just a group of people with different perspectives, tackling a crucial problem."We got the water heater into the room, and the first thing [the group] said to us was 'This is just a mess,'?" Nolan recalls. Not the product, but the design. "In terms of manufacturability, it was terrible."The GeoSpring suffered from an advanced-technology version of "IKEA Syndrome." It was so hard to assemble that no one in the big room wanted to make it. Instead they redesigned it. The team eliminated 1 out of every 5 parts. It cut the cost of the materials by 25 percent. It eliminated the tangle of tubing that couldn't be easily welded. By considering the workers who would have to put the water heater together—in fact, by having those workers right at the table, looking at the design as it was drawn—the team cut the work hours necessary to assemble the water heater from 10 hours in China to two hours in Louisville .In the end, says Nolan, not one part was the same . So a funny thing happened to the GeoSpring on the way from the cheap Chinese factory to the expensive Kentucky factory: The material cost went down. The labor required to make it went down. The quality went up. Even the energy efficiency went up. GE wasn't just able to hold the retail sticker to the "China price." It beat that price by nearly 20 percent. The China-made GeoSpring retailed for $1,599. The Louisville-made GeoSpring retails for $1,299.


text:
on February 8, 2013 - 1:00 AM
, updated February 8, 2013 at 7:04 AM
In a 2009 interview with The Guardian, a British newspaper, playwright Joe DiPietro remarked that his recent play about the sexual habits of gay men contained "no actual shenanigans" on stage.
Leave it to Buffalo United Artists, a frequent producer of risqué and progressive gay theater in which full frontal male nudity is standard practice, to sidestep that idea.
In "F------ Men," the title of which is an intentionally crude double-entendre designed to excite DiPietro's intended audience and compel buttoned-up theatergoers to steer clear, those shenanigans are practically omnipresent. And while there really is no "actual" activity of the sort the play's various hormone-driven characters constantly engage in, this large cast assembled by director and BUA founder Javier Bustillos does its best to convince you otherwise.
Which is to say: Leave your imagination at home with the kids, because BUA's hilarious, intermissionless production doesn't leave much for it to do. And that's just the way Bustillos and company have designed it.
DiPietro's play is not just skin-deep. This, after all, is the author of "I Love You, You're Perfect, Now Change," one of the longest running off-Broadway shows in history and a sensitive exploration of the romantic peaks and valleys that couples of all kinds experience. (A production of that show will open in the Kavinoky Theatre on June 14.)
For all its playful and shameless titillation, the play is a clever if not exactly boundary-breaking consideration of the ways in which gay men from a cross-section of American society connect to one another. It is based on the late-19th century play "La Ronde" by Arthur Schnitzler, a heterosexual exploration of precisely the same questions.
The piece, in its clever borrowed structure and suitably snappy dialogue, covers familiar territory for BUA's target audience. The perpetual topic for many of these genre pieces is the constant tug-of-war between promiscuity and monogamy and characters' attempts to find a place for themselves somewhere in the uncomfortable territory between.
The characters are quickly sketched archetypes – the closeted actor (Michael Seitz), the horny college kid (Steven Brachmann), the husband who messes around (Brant Adamczyk), the husband who can't bring himself to mess around (Joey Bucheker), etc. – and their simplicity serves the simple conceit of this play well.
It's divided up into a dozen or so vignettes, each one linked to the next by some interstitial hanky-panky.
We first meet the young escort John (Jimi Konidis) and the soldier Steve (James Wild), who spend five illicit minutes in a public park. We flash forward to Steve spending five illicit minutes in a gym sauna with the young grad student Marco (James Mikula). Then Marco meets Kyle; Kyle meets Leo (Bucheker); Leo argues with his husband Jack (Adamczyk); and Jack screws around with a porn star (J.R. Finan).
Along the way, the young playwright Sammy (played by young playwright Matthew Crehan Higgins, clearly a stand-in for DiPietro) hooks up – in an actual closet – with closeted screen star Brandon, who he drives to come out of the closet on the national television show hosted by his fellow closeted friend Donald (Richard Fanning).
The performances in this show are all over the map quality-wise, but DiPietro's largely playful material withstands the sometimes rough treatment it receives.
Things come full-circle in a satisfying way, although no one seems to truly resolve the issues that vex them.
DiPietro, clever playwright that he is, spares us from contrived epiphanies that lesser talents might have tossed in as morality lessons to wrap the piece up in a neat little package.
There are no epic realizations, no tidy solutions, no soul-shattering lessons in "F------ Men." But there don't need to be. The play succeeds merely by living up to its title.
3 stars (Out of four)
What: "F------ Men"
When: Through Feb. 23
Where: Buffalo United Artists Theatre, 119 Chippewa St.
Tickets: $15 to $25
Info: 886-9239 or www.buffalobua.org.
email: firstname.lastname@example.com


text:
Top Definition
not awesome, lame
George Bush is bumpy.
от JBBLEK 10 юли 2008
Trending Now
Can you define these popular missing words?
A girl with a nice ass and titties, and/or is voluptuous.
Guy 1: "Damn, that bitch is fine! Look at dem ass and titties."
Guy 2: "Yea man, that bitch is bumpy!!"
Guy 2: "Yea man, that bitch is bumpy!!"
от jasim 26 ноември 2011
when a wireless internet connection continuously switches between a good and bad signal strength so that when browsing, pages will load either immediately, incredibly slowly, or just not at all
I wish the internet would quit being so bumpy so that I could surf through some porn and grease my gator.
от LustyBear 09 септември 2009
Seagrams Extra Dry Gin..... called bumpy for its bumpy exterior texture.
Me and lil hardknock got fucked up last night off that bumpy and orange juice.
от D_style 27 ноември 2006
n. Seagram's Gin. Known as bumpy because of its bumpy bottle.
Me: I got a bottle of the bumpy, a 2 liter of Canada Dry and got all blotto.
от roller 25 май 2005
The practice, encouraged by social services and some psychologists, for children to use a plush toy to masturbate to release sexual tension in hopes that they won't act out.
Get out of my room, I'm doing my bumpies!
от Bumpies! 17 май 2011
1. A poop outside of a toilet 2. Something out of place
Oops I made bumpy again!
от Dan is my name 05 юни 2013


text:
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text:
on January 2, 2013 - 11:43 PM
LOCKPORT – Niagara County Refuse Disposal District Director Richard P. Pope, who was placed on administrative leave Nov. 1 because of alleged violations of county policies, resigned Wednesday.
County Manager Jeffrey M. Glatz said Pope came to his office and handed him a letter of resignation.
Since Pope was accused of violating policies on personal use of county vehicles and on residency within the county, there had been behind-the-scenes communications between Pope's attorney and counsel for the county, aimed at resolving the situation without the County Legislature having to hold a triallike civil service hearing aimed at firing him.
Glatz denied that Pope's resignation was part of such a negotiated settlement. "I wasn't expecting it at all," Glatz said.
Glatz did not supply a copy of Pope's letter. "He saw us heading in a different direction, with closure," Glatz said. "What my focus is, is an intention to settle this and move forward."
Pope, who earned $67,681 a year, had been director of the district since 1993. He could not be reached Wednesday night.
Although county environmental coordinator Dawn M. Timm has been in charge of the district's day-to-day operations since Pope went on leave, Legislator John Syracuse, chairman of the Refuse District board, said he thinks the directorship should not be filled, at least for the time being.
"I would like to see the position held in abeyance until we get some recommendations from the county manager," said Syracuse, R-Newfane. "Is this a service we really need to provide? Does it make money?"
Glatz and Pope had a public confrontation at a Refuse District board meeting Oct. 22 over the future of the district's only active landfill.
The construction and demolition landfill off Route 93 in Lockport is running out of room, although how long it can last is a topic of dispute. Pope insisted that landfill was operating at a profit, but Glatz emphasized that the district as a whole was not because it had to impose property taxes to balance its budget.
As far back as June, Glatz recommended the shutdown of the landfill. The district also is responsible for monitoring two closed landfills, one in Lockport and one in Wheatfield.
Syracuse said Timm has issued memos suggesting cost-cutting measures for the district.
"Dawn Timm has been doing a great job so far. That's what I expect from department heads," Syracuse said.
The 2013 county budget eliminated one vacant job at the district immediately, with two filled positions slated to be cut as of July 1.
Glatz, who had promised a public report on the charges against Pope, said Tuesday there probably won't be one, although he said he might brief legislators behind closed doors.
He hinted that the residency charge might not have gone anywhere, noting that Pope is registered to vote in the City of Lockport. County employees are required to live within Niagara County unless they have a Legislature waiver.
He said he wouldn't discuss the vehicle use charge. The county has a policy generally barring private use of county vehicles. Glatz said he may suggest revisions based on the Pope case.
email: firstname.lastname@example.com


text:
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Country music star Miranda Lambert will perform at Wisconsin State Fair on the event's final night, Aug. 11.
The show will begin at 6:30 p.m. on the Main Stage.
Tickets are $39 or $49 and go on sale at 10 a.m. Feb. 15 at WiStateFair.com and the fair ticket office.
Country trio The Farm will open the 6:30 p.m. show.
This year's state fair runs Aug. 1-11.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


text:
While Merrill Lynch may be one of the few firms projecting
a win for the Xbox 360 by 2011, a new cost analysis for the PlayStation 3
puts a few more things into perspective with regards to the next generation
console battle.
It looks as though Ken Kutaragi was right when he stated
that the PS3, which will be priced at $499 and $599 respectively in the United
States, is probably "too cheap."
According to a new cost analysis by iSuppli, Sony will lose $307 for every 20GB
PS3 it sells and $241 for each 60GB version. "With Sony taking a
smaller loss on the higher-end model, it's not a surprise the company is
steering customers to the 60Gbyte version," said iSuppli. For the United
States, 20GB PS3s will account for 20% of the sales mix
while the 60GB versions will take the remaining 80%.
Although its initial losses with the PS3 will be large, Sony
co-chief operating officer Jack Tretton points out that the original PS and the
PS2 became "incredibly" profitable after taking massive losses at
iSuppli summed up it results
by stating "While many fret over the high cost and price of the PlayStation 3
compared to the competition, iSuppli believes the console provides more processing
power and capability than any consumer electronics device in history. Because
of this, the PlayStation 3 is a great bargain, well worth its $599 price and
$840.35 cost, iSuppli believes."
Microsoft, which was once seeing red to the tune of $153
per unit sold, is now making a profit of $75.70 on each console before
marketing and distribution costs a year after launch.
Nintendo has already stated that it will make a profit on
every Wii that it sells. Given that CompUSA lists its cost for the Wii
at $237.50, Nintendo's actual costs are likely closer to the $200 mark.
That shouldn't be too surprising given that Microsoft's Richard Teversham likened
the Wii to a Gamecube
with a DVD drive (someone should tell Tevesham that the Wii doesn't actually
play DVDs…for now).
quote: $840 to produce sounds way too high though. You could build a nice PC for that, that would kick the PS3's electronic butt.
quote: "...one of a kind CPU..." -Playto
quote: The first thing you have to keep in mind is that Cell's architecture is nothing revolutionary, it's been done before. -Anand
quote: The Cell processor doesn't get off the hook just because it only uses a single one of these horribly slow cores; the SPE array ends up being fairly useless in the majority of situations, making it little more than a waste of die space.


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Kay Granger
Inducted 1998-1999
Congresswoman Kay Grangers long-standing public service is indicative of her desire to improve the lives and communities of those who call Texas home. She was the first Republican woman from Texas to serve in the U.S. House of Representatives. During her first year in Congress, Congresswoman Granger established a record as a rising star of the freshman class, according to the Capitol Hill newspaper Roll Call.
The day she was sworn into office she introduced legislation to require that both the president and congress present certified balanced budgets. Later, as a member of the House Budget Committee, Granger not only helped write the first balanced budget since 1969 but also implemented the first tax cuts since 1981.
A lifelong resident of Fort Worth, Congresswoman Granger served as mayor from 1991 to 1995. During her tenure she reduced crime by 49 percent and attracted several new businesses. Her success as mayor was recognized when Fort Worth received the prestigious All-American City award from the National Civic League.
Congresswoman Granger has served on numerous committees. In 2003 she is an Assistant Majority Whip and serves on both the House Budget Committee and the powerful House Appropriations Committee. She also serves on three important appropriations subcommittees: Transportation, Military Construction and Labor-Health and Human Services. Her hard work and dedication to serve others gained national recognition. It is little wonder that George magazine listed Congresswoman Granger as one of the most compelling freshman of the 105th Congress. The Washington Times called her the most often mentioned newcomer to Congress, and Roll Call urged its readers to keep an eye on Granger.
She has touched the lives of many through her dedication, duty and honor as a public servant to her community, to her native State of Texas and her nation. As a member of Congress she continues working with dignity and pride toward a better Texas and a better America.
page last updated 8/16/2016 10:54 AM


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WASHINGTON, D.C., 7 June 2012 – The Global Environment Facility's governing council today completed its 42nd meeting approving the largest work programme to date for addressing global environmental challenges.
The 32-member Global Environment Facility (GEF) Council unanimously approved an allocation of USD 667 million for 84 new stand-alone projects, two conceptual programmatic approaches, and 13 revisions to previously approved projects. Those funds will be bolstered by USD 4.4 billion in co-financing – funds raised from other sources, such as non-governmental organizations, international institutions, the private sector, regional authorities, and recipient governments. This co-financing ratio of 6.6-to-1 reflects the effort by GEF CEO and Chairperson, Monique Barbut, to obtain maximum leverage from the resources GEF raises from among its 182 member nations.
"The GEF is not just a funder of global environmental projects," said Barbut. "It is a catalyst generating much broader financial support for addressing threats to our environment and toward our endeavors to bolster local and national economies through sustainable development."
Barbut was attending her last GEF Council meeting as CEO. Her second term as head of the GEF expires on 31 July. The Council today unanimously named Naoko Ishii of Japan as her successor.
The work programme involves the distribution of funds across all of the GEF's focal areas, including climate, international waters, persistent organic pollutants, desertification, biodiversity and ozone depleting substances. The Council expressed unanimous support for the robustness of the work programme, congratulating the Secretariat, the donor nations, participating countries, the United Nations Environment Programme's Scientific and Technical Advisory Panel, and the GEF Agencies for the work in putting together the ambitious programme.
This latest GEF work programme is remarkable not only for its size but also due to key innovations. The programme seeks to address environment issues in a more holistic and comprehensive manner than has been typical previously. It is a strategy that reflects the growing understanding in the environmental community of the inter-relationship between threats to the environment such as desertification and climate change, marine degradation and destructive land-use practices, and so on. In this programme, 25 of the 84 projects cover multi-focal areas.
Among the single focal area projects, there are 23 in biodiversity, 26 in the climate change field, with the remainder split among a variety of focal areas. The work programme includes notable large-impact programmes. For example, the Council endorsed two public-private partnership programmatic approaches for a total of more than USD 20 million in climate change. These funds will enable the scaling up of renewable energy technologies on the African continent and contribute to the delivery of universal power supply in the region. Through the support for renewable energy projects, the programme will contribute to reducing greenhouse gas emissions across the African Continent.
Other examples of a large-impact programme are a global project in land degradation and encompassing 47 countries in Asia, Africa and Latin America, which will finance activities in support of National Action Programmes (NAPSs) to help bring them into alignment with the United Nations Convention to Combat Desertification 10-Year Strategy and reporting process; and a regional project involving Antigua and Barbuda, Barbados, Cuba, the Dominican Republic, Grenada, Jamaica, Saint Kitts and Nevis, Saint Lucia, and Saint Vincent and Grenadines, which has been approved with a grant of USD20 million. The aim of the latter is to accelerate the achievement of global targets on access to safe and reliable water supplies and improved sanitation.
The project will enhance the functioning of ecosystems of global importance within the Caribbean Sea basin and in Caribbean Small Island Developing States (SIDS). In particular, it addresses adaptation to climate change through an integrated approach to water, land and ecosystem services management. It involves policy development, institutional and legislative reforms, improved technologies and methodologies. Ultimately, the best practices developed under this project may prove applicable across the globe.
The GEF Council expressed its continued support for the establishment of the Climate Technology Centre and Network (CTCN), being set up under the United Nations Framework Convention on Climate Change. This innovative initiative involves GEF efforts in the climate technology sector, with about US$9 million committed to each of three regions, Africa, Latin America and the Caribbean, and Europe and Central Asia.
For more information, please contact:
John Diamond
Senior Communication Officer | Spokesperson
Phone +1 202 458 7953


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Aqua Zumba
Splashing, stretching, twisting, shouting, laughing, hooting and hollering – that's Aqua Zumba classes for you.
Integrating the zumba dance class with traditional aqua fitness disciplines, Aqua Zumba - or water zumba - blends it all together into a safe, challenging, water-based workout that's cardio-conditioning, body-toning, and most of all, exhilarating beyond belief.
Known as the zumba 'pool party', aqua zumba classes give new meaning to the idea of an invigorating workout.
Do I need any aqua zumba equipment?
Just your swimming costume and anything you normally take to the pool. And of course you'll need a sense of fun and your very own wiggle!
How do I get involved?
Use our Pool Finder to locate your nearest pool. Get in contact and ask them about aqua zumba.
Bring the party to the pool and give it a go!


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Parks and Recreation Turf n Turf Flip T-Shirt
Whats the Turk N Turf you ask? Well, its a 16 oz T-bone and a 24 oz Porterhouse, also whisky and a cigar. Show youre a free American who can consume whatever you chose with the Parks & Recreation Turf N Turf Flip T-Shirt. The soft red tee reads Ask me about Turn N Turf on the front and flips over to replace your face with the mug of Ron Swanson. Show youre serious about your meat and your Parks & Rec with this sweet tee.
Read MoreLess
More Details
- Color: Red
- Gender: Unisex
5.05.0(1 review)See all 1 review
Reviewed by 1 customer
- Figure Flattering
- Great Colors
- Versatile
Best Uses
- Casual Wear
Comments about this product:
I like wearing this shirt and getting taken aside. True fans give my a sly wink and smile. I always get asked something. Swansonites relish it and Parks & Rec fans says Pawnee Forever!
- Was this a gift?:
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Coach Gus Bradley said he will stick with Blaine Gabbert as his starting quarterback.
The Dallas Morning News reports the Cowboys have fined Dez Bryant for missing meetings and an MRI related to his knee injury.
Seahawks signed RB C.J. Spiller to a one-year contract.
Jamaal Charles (knee) remained limited at Wednesday's practice.
Ezekiel Elliott said he feels "way more comfortable" in the Cowboys' offense than he did in Week 1.
ESPN's Rich Cimini reports the Jets are "concerned" about Eric Decker's shoulder injury.
Jets released CB Dee Milliner from injured reserve.
Michael Floyd (concussion) has been cleared for football activity.
T.Y. Hilton (knee) didn't practice on Wednesday.
Titans coach Mike Mularkey expects Delanie Walker (hamstring) to play Sunday.
Tevin Coleman (ankle) was limited at Wednesday's practice.
Antonio Gates (hamstring) is not practicing Wednesday.


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Penn State Abington student performers celebrate the music and the words of women in the performing arts.
The production runs deep into the history of women composers and playwrights. It brings to you vignettes of plays from "The Rover" written by Aphra Behn, "A Raisin in the Sun" written by Lorraine Hansberry and "The Vibrator Play" written by Sarah Ruhl and others.
The play also includes music by Alicia Keys, Janis Joplin, Patti Smith, Rosetta Thorpe, Nina Simon, Aerosmith and more!
Don't miss an opportunity to be captivated by these up-and-coming actors and singers.
Sutherland Auditorium, Admission: $5.


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|November 7, 2007
|Is Consumerism Harmful?
|by Andrew V. Abela
|October 31, 2007
|Does Fair Trade Help the Poor?
|by Michael Matheson Miller
|October 24, 2007
|Free Trade: Latin America's Last Hope?
|by Samuel Gregg
|October 24, 2007
|Bill Cosby Is Right, Again
|by Anthony B. Bradley
|October 17, 2007
|Who's Afraid of Free Trade?
|by Michael Matheson Miller
|October 10, 2007
|Islam's Quiet Revolution
|by Samuel Gregg
|October 3, 2007
|Abandon SCHIP: Big Government Returns
|by Ray Nothstine
|September 26, 2007
|Central Banking's Hazardous Ways
|by Samuel Gregg
|September 19, 2007
|Islam's Money Problem
|by Samuel Gregg
|September 12, 2007
|Democracy in Iraq
|by Jordan Ballor
|September 5, 2007
|Credit Crunch, Character Crisis
|by Samuel Gregg
|September 5, 2007
|Obviously, Sports Do Not Build Character
|by Anthony B. Bradley
|August 29, 2007
|What's Wacko about Sicko
|by Donald P. Condit
|August 22, 2007
|A Liberal Education and "Free" Federal Financing
|by Brooke Levitske
|August 22, 2007
|Saving Europe's Money
|by Samuel Gregg
|August 15, 2007
|Minimum Wage, Maximum Suffering
|by Rev. Robert A. Sirico
|August 8, 2007
|Darfur: Taking Student Advocacy beyond the Wristband
|by Kaylin Wainwright
|August 1, 2007
|Schumpeter's Paradox: Wages, Wealth, Incentives
|by Samuel Gregg
|July 25, 2007
|'War On Poverty' Remix Won't Work Either
|by Anthony B. Bradley
|July 18, 2007
|The Problem of Equality
|by Samuel Gregg
|July 11, 2007
|Illegal Immigration and the Church: Philanthropic Lawlessness
|by Brooke Levitske
|July 4, 2007
|Follow the Money: Stem Cells and Subsidies
|by Jennifer Roback Morse
|June 27, 2007
|'Big Corn' and Unintended Consequences
|by Ray Nothstine
|June 20, 2007
|Goodbye, World Bank?
|by Samuel Gregg
|June 13, 2007
|China's Stealthy Globalization
|by Anthony B. Bradley
|June 6, 2007
|The Church and Globalization
|by Brian Griffiths
|May 30, 2007
|Population and Poverty
|by Michael Matheson Miller
|May 23, 2007
|Government Divides, Families Unite - Pope Leo XIII saw it coming
|by Jennifer Roback Morse
|May 11, 2007
|Does the Pope Blast Capitalism?
|by Rev. Robert A. Sirico
|May 9, 2007
|Mothers, Earth
|by Kevin E. Schmiesing


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BUCYRUS - Buckeye Central remained unbeaten on the season with a victory over Wynford, and if Adam McGinnis keeps shooting the way he does, it will be tough for anyone to hand the Bucks a loss.
McGinnis fired a 38 to lead the Bucks to a 175-185 victory over Wynford.
Tanner Zaebst backed him up with a 44, Derek Shell fired a 46 and Zach Parker and Matt Sheibley each shot 48.
Buckeye Central is now 6-0, 4-0 North Central Conference.
Blue Jackets out-pace Calvert at Seneca Hills
The teams shared the medalist honors, but New Riegel took the win Tuesday, beating Calvert 192-211 at Seneca Hills.
New Riegel's Lance Smith and Calvert's Matt Huffmon each carded a 45.
Aaron Reinhart and Travis Williams backed Smith with twin 47s for the Blue Jackets (2-2).
Bryan Kennedy added a 46 for the Senecas (0-1).
Shelby beats out Columbian
SHELBY - Jack Burkes fired a 42 for Columbian, but it wasn't enough as Shelby dropped Columbian in Northern Ohio League play, 179-189. Sam Boyce posted a 39 for the host Whippets and Joey Rittenhouse added a 43.
For Columbian, T.J Wickham added a 47, Wesley Henkel shot a 48 and Eline Widman carded a 52.
Pair of Buckettes lead way
UPPER SANDUSKY - Two Buckeye Central players broke 50 Tuesday as the Buckettes defeated Clear Fork 216-224 at Cranberry Hills.
Lydia Shealy's 47 and Maddie Fagan's 49 sparked the Buckettes (4-4).
Clear Fork got a 51 from Maria Zeller and a 56 from Caitlyn McCartney.
Pair leads the way for Tigers
Johnny Diehm and Riley Kalb fired 39s Tuesday to fuel Seneca East's win in a quadrangular at Clinton Heights.
The Tigers overpowered Mohawk 168-182, with Old Fort taking third (184) and Bettsville finished fourth (250).
Austin Holmer backed up Diehm and Kalb with a 44 and Braden Nagel shot a 46 for Seneca East.
Brayden Dunlap's 42 keyed the runner-up Warriors, and Billy Dunlap added a 44.
Old Fort got 43s from Adam Alexander and Maison Steyer.
Ryan Hager's 52 and Kyle Hager's 60 led Bettsville.


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These data were generated through a number of steps. We started by culling several other databases for records that pertain to grounded sunk and abandoned vessels. These records made our base record set in 2001. From that point forward, we have been working to add and improve the core data set through a number of efforts. We collect information from our website, from the media, from direct interviews and through field surveys. All of these data are used to categorize and prioritize individual records. Many vessels have been assigned a removal priority from high to low depending on a number of factors including threats to public safety, the environment, navigation and aesthetics. Other vesselss, with very little information, are not prioritized until we develop better data.
The primary data sources are the US Coast Guard's Abandoned Vessel Inventory System and Marine Safety Management System, NOAA's Automated Wreck and Obstruction Information System and Florida's Derelict Vessel Removal Grant Program.


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Durango native Irma J. McNamara died Sunday, June 17, 2012, at Sunshine Gardens West. She was 95.
Mrs. McNamara was born Dec. 15, 1916, to Arthur Henry Ford and Mary Therese Neary Ford Hammer in Durango. She attended St. Columba Elementary School and graduated from Durango High School in 1936.
After graduating, Mrs. McNamara worked for Turner Securities. She married John J. �Johnny� McNamara in 1940, and the couple lived a short time in California during World War II while Mr. McNamara served in the U.S. Navy.
After returning to Durango, Mrs. McNamara worked for the La Plata County Clerk�s Office and later the Everett Monger Adjustment Firm. She retired as practice manager for the Southwest Colorado Mental Health Center when Mr. McNamara was critically injured in an electrical accident. They spent a large amount of time in Pittsburgh after his subsequent liver transplant.
Mrs. McNamara was a former member of Catholic Daughters of America, St. Columba�s Altar and Rosary Society and the Colorado Mental Health Professional Office Managers Association. She also was a charter and active member of the Durango Sewing Club, founded in 1940, as well as a recipient of Rotary�s Paul Harris Award.
An excellent cook, Mrs. McNamara loved picnics, four-wheeling and camping, in both the Colorado mountains and the Utah canyonlands. She also loved flowers and had her own small rose garden (although a small herd of deer would beg to differ), her family said.
�Irma was devoted to family, friends and faith,� her family said.
Mrs. McNamara was preceded in death by her husband, John J. McNamara; infant son John J. McNamara Jr.; and grandson John Kennedy.
She is survived by her daughters Patricia F. Tibbetts of Durango and Mary Ann Beavers of Denver; three grandchildren; and two great-grandchildren.
Visitation will be held from noon to 5 p.m. Thursday, June 28, 2012, at Hood Mortuary Chapel. A rosary will be recited at 6 p.m. Thursday, June 28, 2012, at St. Columba Catholic Church, 1830 East Second Ave. A Mass of Christian Burial will be celebrated at 11 a.m. Friday, June 29, 2012, also at St. Columba. A graveside service will be held at Greenmount Cemetery.


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Amyloidosis CenterFondazione IRCCS Policlinico San MatteoUniversity of PaviaPavia, Italy
Systemic AL amyloidosis is a plasma cell disorder characterized by the overproduction and tissue deposition of a monoclonal immunoglobulin light chain (LC), or fragments containing the LC variable region and a portion of the constant region. The deposits are composed of amyloid fibrils, presenting a cross beta supersecondary structure. The process of amyloid deposition produces tissue damage and eventually organ failure, leading to death in untreated patients (1).
The optimal management of patients with AL amyloidosis requires early diagnosis, correct amyloid typing, effective treatment, tight follow-up and careful supportive therapy. One of the most important determinants of outcome is early diagnosis, as severe amyloid organ disease may preclude the use of potentially effective treatment regimens. The systemic involvement affecting vital organs such as heart, kidney and liver renders these patients particularly fragile and sensitive to the toxicity of chemotherapy.
Early diagnosis depends on the level of alertness of the physician: any patient with nephrotic-range proteinuria, unexplained right-sided heart failure, progressive peripheral neuropathy, unexplained hepatomegaly or functional hyposplenism, orthostatic hypotension and other manifestations of autonomic neuropathy with weight loss should be screened for amyloidosis. The diagnosis of AL is biopsy based and requires the presence of deposits with apple green birefringence after Congo red staining, or the prototypic, nonbranching, 10-nm diameter fibrillar structures by electron microscopy. Fine-needle aspiration of abdominal fat is innocuous, fast, inexpensive, and sensitive (87%) (2). The method is based on the almost constant involvement of subcutaneous adipose tissue in AA, AL and ATTR forms of systemic amyloidosis, and probably in other systemic amyloidoses as well. Amyloid is found both in the walls of small vessels and around the individual fat cells. False-positive Congo red-stained biopsies occur because of overstaining and inexperienced review. If the abdominal fat is negative, the second choice biopsy site at the Pavia Amyloid Center is the minor labial salivary glands. Renal and hepatic biopsies carry a small risk of bleeding and often require overnight hospitalization. Once the diagnosis of amyloidosis has been established histologically, the type must be determined because the prognosis and treatment depend on the biochemical amyloid forms. There are specific treatments available for some systemic amyloidoses, this means that exact and safe determination of the type of amyloid deposit in the individual patient is critical. This can be accomplished using immunohistochemistry, immunoelectron microscopy (3) or by biochemical methods which are applicable also to formalin-fixed tissue samples (4). Immunohistochemistry is usually reliable for identifying or ruling out AA amyloidosis, but is frequently not diagnostic with respect to AL amyloidosis. Immunoelectron microscopy and biochemical methods provide definitive results; however, they are labor-intensive and require expertise. If these techniques are not available, the DNA analysis should be performed upfront in order to exclude the hereditary amyloidoses whose clinical presentation is consistent with the patient's manifestations. In order to characterize the amyloidosis of AL type, a plasma cell clone should be documented. The demonstration of the clone requires sensitive techniques. The bone marrow should always be examined, bearing in mind that, typically, the amyloid plasma cell clone infiltrates the bone marrow to a modest extent (median bone marrow plasma cell percentage 7%), often requiring anti-light chain immunohistochemistry/immunofluorescence for and light chains to be identified. Accordingly, also the circulating monoclonal protein is usually present at low concentration, being missed by screening serum electrophoresis in approximately 50% of patients. Therefore, all patients with a clinical suspicion of AL amyloidosis should undergo sensitive immunofixation electrophoresis of serum and urine that is able to detect a monoclonal protein in up to 97% of patients (2). The quantification of serum-free light chains (FLC) may complement immunofixation and represents now an irreplaceable tool for monitoringresponse to therapy. Evidence of progression or regression of amyloid deposits can be obtained from serum amyloid P (SAP) component scintigraphy.
Due to the relatively high prevalence of a monoclonal protein in the adult population the possibility of a chance coexistence of a monoclonal protein in a patient with hereditary amyloidosis should always be considered (5). Clinically, it is difficult to distinguish AL from reactive, familial, and senile systemic forms of amyloidosis, because of their overlapping clinical presentations and the lack of an informative family history in half of the patients with hereditary amyloidosis. Since mistyping of amyloidosis may have catastrophic therapeutic consequences, such as transplanting hematopoietic stem cells instead of liver, great care should be devoted to the diagnostic process. When two possible sources of amyloid have been identified, patients should be referred to centers specializing in amyloidosis for further evaluation.The prognosis of AL amyloidosis has significantly improved in the last decade due to earlier diagnosis and more effective specific and supportive treatments. The median survival of patients with AL ranges from approximately 2 years to 3.9 years, depending in part on the treatment center and the nature of referral pattern. The median survival of 822 patients with AL amyloidosis followed in Pavia is 47 months. Recently we have investigated the factors affecting renal survival in patients with amyloid renal involvement: serum creatinine, proteinuria and young age at diagnosis predicted the progression to dialysis. Response to chemotherapy prolongs both renal and overall survival. The most frequent cause of death in these patients is progression of amyloid cardiomyopathy. Actually, most patients with AL amyloidosis die of cardiac complications (~ 75% in our 822 patient population), either congestive heart failure or sudden death. Cox multivariate analysis showed that the only 2 significant independent prognostic factors were response to therapy (protective), and cardiac involvement. Median survival of patients with heart involvement was significantly shorter than that of patients without cardiac amyloidosis (24 vs 81 months, p<0.001), and patients who obtained a hematologic response to chemotherapy survived longer than other patients (median 96 vs 20 months, p<0.001). Our recent data indicate that patients with cardiac AL amyloidosis who achieve hematologic response to chemotherapy have a better outcome than non-responsive patients (median survival 68 months vs 11 months, p<0.001) irrespective of the severity of heart involvement at diagnosis. Elevated serum cardiac troponins are related to poor prognosis in AL patients (6) and our group reported that the serum N-terminal portion of natriuretic peptide type B (NT-proBNP) is a sensitive marker of myocardial dysfunction in AL and a powerful prognostic determinant (7). These two cardiac biomarkers were used to develop a reliable staging system for AL patients that can be used to stratify patients in randomized clinical trials and to compare outcomes between therapeutic interventions when randomized clinical trials are not available (8). NT-proBNP clearance relies almost exclusively on glomerular filtration while natriuretic peptide type B (BNP) is eliminated from plasma through both glomerular filtration and clearance receptors that promote its degradation. Therefore, it is likely that BNP will prove to be a more reliable marker of cardiac dysfunction than NT-proBNP in AL patients with advanced renal disease. In most of the patients, the reduction of the circulating FLC concentration induced by chemotherapy translates into a reduction of serum NT-proBNP level and improving of heart failure, often before any reduction in amyloid load can be demonstrated at echocardiography (9). This observation indicates that serum NT-proBNP can be used as a marker of cardiac response to therapy. It has been reported that normalization of FLC levels after peripheral blood stem cell transplantation predicted both complete hematologic response and organ response (10). The concurrent quantification of the FLC and of NT-proBNP in patients with cardiac amyloidosis allows titration of the anticlone treatment improving the toxicity-benefit ratio and allowing a prompt change of therapy in the case of an inadequate response.
References1. Merlini G, Stone MJ. Dangerous small B-cell clones. Blood. 2006;108:2520-30.2. Obici L, Perfetti V, Palladini G, Moratti R, Merlini G. Clinical aspects of systemic amyloid diseases. Biochim Biophys Acta. 2005;1753:11-22.3. Arbustini E, Morbini P, Verga L, Concardi M, Porcu E, Pilotto A, et al. Light and electron microscopy immunohistochemical characterization of amyloid deposits. Amyloid. 1997;4:157-70.4. Murphy CL, Eulitz M, Hrncic R, Sletten K, Westermark P, Williams T, et al. Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens. Am J Clin Pathol. 2001;116:135-42.5. Comenzo RL, Zhou P, Fleisher M, Clark B, Teruya-Feldstein J. Seeking confidence in the diagnosis of systemic AL (Ig light-chain) amyloidosis: patients can have both monoclonal gammopathies and hereditary amyloid proteins. Blood. 2006;107:3489-91.6. Dispenzieri A, Kyle RA, Gertz MA, Therneau TM, Miller WL, Chandrasekaran K, et al. Survival in patients with primary systemic amyloidosis and raised serum cardiac troponins. Lancet. 2003;361:1787-9.7. Palladini G, Campana C, Klersy C, Balduini A, Vadacca G, Perfetti V, et al. Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis. Circulation. 2003;107:2440-5.8. Dispenzieri A, Gertz MA, Kyle RA, Lacy MQ, Burritt MF, Therneau TM, et al. Serum cardiac troponins and N-terminal pro-brain natriuretic peptide: a staging system for primary systemic amyloidosis. J Clin Oncol. 2004;22:3751-7.9. Palladini G, Lavatelli F, Russo P, Perlini S, Perfetti V, Bosoni T, et al. Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL. Blood. 2006;107:3854-8.10. Dispenzieri A, Lacy MQ, Katzmann JA, Rajkumar SV, Abraham RS, Hayman SR, et al. Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation. Blood. 2006;107:3378-83.


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on January 7, 2013 - 10:55 PM
The estimated price tag of providing future health care benefits for workers who retire from Erie County government has dropped, but the county expects its annual costs for that insurance to rise over the next decade as more employees retire.
The latest estimate for the future cost of providing retirees health care benefits was $789.8 million as of Jan. 1, 2012, down $187.8 million from two years before that, according to a recent report prepared for Erie County. Actuaries attributed the decrease to several factors, including reductions in the number of workers and new union contracts for some employees that will require them to pay a portion of their health care costs in retirement.
The report, prepared by Harbridge Consulting Group, estimated that the amount the county will pay each year for retiree health insurance will grow from $20.5 million in 2012 to $40.2 million by 2022. The county attributed that growth to the number of retirements expected over the next decade "due to the advanced age" of the county's workforce.
The county is required to report the actuarial present value of future benefits in its annual financial statements.


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CLEMSON – Just as many others look up to Kathleen Swinney, the wife of Clemson's head football coach draws on her own inspirations.
2013 Dabo Swinney Ladies Clinic
Saturday, July 20
Check-in starts at Littlejohn Coliseum at 7:15 a.m.
Program begins at 9 a.m.; concludes in Death Valley at 4 p.m.
Meet and Greet photo with Dabo Swinney for first 250 through the gate
Coaches' instruction clinics, interaction with coach families, facility tours
Lunch provided by Wendy's
Fashion show, silent auctions, special guest speakers
Registration fee is $60; $15 is matched by Dabo's All In Foundation, with proceeds going to breast cancer research and prevention
Her older sister, Lisa, was diagnosed with breast cancer in 2003, and while she won her fight, she continues to kick complications a decade later.
Robin Roberts, former ESPN reporter and current Good Morning America anchor, beat both breast cancer in 2007 and myelodysplastic syndrome – a blood cell disease caused by bone marrow failure – earlier this winter.
It was the famous broadcaster's decision to publicize her quests back to health rather than hide them in privacy. When accepting an ESPY Courage award Wednesday, Roberts' powerful tagline was "make your mess your message."
In her own way, Swinney does that every summer with the help of her husband's football program and foundation.
Clemson's 2013 Dabo Swinney Ladies Clinic powers on since its roots from the Tommy Bowden days, and in the Swinneys' fifth year leading the charge, they expect a record 1,200 women on campus for Saturday's daylong festivities.
No men allowed: the event teases red-blooded males with the mantra "what happens at Ladies Clinic stays at Ladies Clinic."
"It covers a broad spectrum of ladies," Kathleen Swinney said. "There's something for everyone, whether she's a football fanatic, she's a shopper and just wants to have a good time, or she's interested in breast health."
Swinney's all three. To the latter point, very much so.
After Lisa began her battle in her 30s, Kathleen and little sister Ann were tested for the BRCA gene, the same gene Angelina Jolie has in her body that increases the odds of breast cancer.
They tested positive, and responded by getting a double mastectomy to stunt the gene's effects. Kathleen's was in 2005 – during football season, when Dabo was a wide receivers coach.
Lisa knocked her breast cancer into remission, but last year cancer spread to her brain and lungs. She has recovered well from brain surgery at Duke University in 2012, but she's had two lung surgeries this year and caught pneumonia two weeks ago.
"It's affected us in an extremely personal way. It's been an extremely difficult year for our family," Kathleen said. "It's all because of this gene."
Defensive end Corey Crawford lost his mother to breast cancer last year, and offensive lineman Eric MacLain's mom battles it now.
"Most everybody sitting in there either knows a family member or friend who's been affected by breast cancer," Swinney said. "It affects everybody. It's just become an epidemic. So most people are passionate about coming, and they know their money's going toward a good cause."
Clemson University raised more than $20,000 last year for breast cancer research and prevention through Dabo's All In Team Foundation. Other schools like South Carolina, Ohio State, Kentucky and Oregon also host women's clinics.
"If it wasn't for all this research into breast cancer health, I would more than likely have breast cancer right now," Swinney said. "Because I was diagnosed with the gene, I was able to do something about it."
All the Tigers' coaches, and many players, join in Saturday for presentations, photographs, autographs, tours and entertainment. The day is supplemented by lunch, a fashion show, silent auctions, special guest speakers and the recognition of breast cancer survivors.
"It is every man's desire to interact with the players at that level, and you get to know them on a personal level," Charleston County Clemson Club president Heather Byrd. "You go through a day in the life of a player. It's over-the-top fantastic."
A mother of three boys, Kathleen Swinney relishes the day each year.
"I do live with all these men, so it's super fun to have that day with the ladies, knowing what the money's going toward. And showcasing Clemson," she said.
"It's just a really special day."


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Ezekiel Dumke IV
Ezekiel Dumke IV '04
BS Economics
Ezekiel "Zeke" Dumke IV graduated in 2004 with a BS in economics and business. He now has his own law practice. His specialties include complex civil litigation, intellectual property management and enforcement, and small business and corporate contacting and advising. As an attorney, Zeke uses critical and analytical thinking as well as communication and writing skills to understand problems, find creative solutions, and represent his clients. After graduating from Westminster College, Zeke left Utah and obtained a JD from University of San Francisco School of Law, where he participated in the IP Internet Justice Project and edited and contributed to the USF IP Bulletin. Zeke also earned an MBA from Bond University in Queensland, Australia, where he specialized in international business and entrepreneurship.


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HOLLIDAYSBURG - Demolishing what's known as the Russo building will cost only about half of the original estimate.
Blair County commissioners voted Tuesday to hire Dilapidated Demolition of Cumberland, Md., for $122,740 to tear down the blighted structure at 31st Street and South Branch Avenue.
The company submitted the lowest of 12 bids that went as high as $380,000.
When commissioners agreed a few weeks ago to take bids on demolition, they said the cost had been estimated at $250,000 or more.
"I'm glad [the estimates] were wrong," Commissioners Chairman Terry Tomassetti said.
Before starting the job, Dilapidated Demolition owner Stanley Boinovych said he must submit a notice to the state Department of Environmental Protection and put up a fence on the site of the former slaughterhouse. He said he expects to bring in a wrecking ball, concrete-crushing equipment and wood-grinding equipment.
The steel recovered will probably be sold for scrap, he said.
Engineer Joseph Keller of Keller Engineers told commissioners he found favorable comments when checking the company's references.
Commissioner Diane Meling asked Keller if he had any concerns about taking the low bid, when the high bidder asked three times as much to complete the job. Keller said he didn't because the three lowest bids were very close.
They came from Earthmovers Unlimited of Kylertown at $127,319 and Northeast Industrial Services of Shamokin at $133,475.
Boinovych said it's not unusual for him to see a wide range of bids for demolition work.
"It's just the nature of the business," he said.
While this will be his first job in Blair County, he said his company tore down the former East Taylor Elementary School in Cambria County.
Commissioners agreed a few weeks ago to solicit bids for demolition of the structure on property that attracted no bids at the county's last sale of property for unpaid taxes. Under the state's 1947 Real Estate Tax Sale Law, the maintenance of the property rests with the county.
Once Boinovych finishes demolition, commissioners said they hope the site looks attractive to a buyer.


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Top Definition
Offensive English word for someone who has long hair or dresses differently from the rest of the flock. Applied to people into alternative/Rock/Metal music. usually said by immature closed minded people who wear nothing but brand name clothes in various garish colours.
"ya sweaty gegger!!"
po Lee Tatlock Фабруар 5, 2004
Trending Now
Can you define these popular missing words?
A term for a person, who in society, wishes to go un-ranked as any of the social groups.
Someone who listens to Rock/rap and even dance.
Someone who listens to Rock/rap and even dance.
"So you like a goff?"
"No, I'm a gegger."
"Same 'fing init?"
"No, I'm a gegger."
"Same 'fing init?"
po Jack Thompson Април 26, 2007


text: Members of the Literacy Volunteers of Randolph County celebrate International Literacy Day recently with a proclamation signing by Elkins Mayor Van Broughton. Joining Broughton are Literacy Volunteers of Randolph County members, front, Maryann Durland, president; Broughton; and Linda Daniels; and back, Judy Seaman, secretary, trainer and regional tech; Barbara McCreary; Cary Hopwood, vice president; and Donna LeMasters. (The Inter-Mountain photo by Beth Christian Broschart)


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Guess who?…Make room at the table KSCO, because Saturdays at 7pm, beginning June 22nd, we're bringing you a new show "Out in Santa Cruz".Join Shaun Ordinario, Boston transplant, husband and Youth Advocate along with Steph Taylor, Santa Cruz native, Mother and Community Leader, for all things local and national with an LGBT perspective.
That's Out in Santa Cruz, Saturdays at 7pm…Tune in and get queered!
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Click Here and Fill Out the Form to Submit a Public Service Announcement
Click Here To Buy


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The Elizabethan excess of the costume suits the contemporary style of the play. HMR
"Much Ado" at The Star Theatre, New York, 13th November, 1884: "In person Miss Terry is an ideal Beatrice, and her voice so rich and expressive, imparts the proper emphasis to the lively bantering of the early scenes, and gives rich color to the succeeding passages of sympathy and love. This performance is also remarkable for its symmetry, and it is so full of important bits of detail that it is worthy to be pointed to as a model for younger actresses. What could be more perfect and delightful in its way than Miss Terry's conduct during the playful scene with the two old nobles in Act I. and how charming that unexpected disclosure of Beatrice's true nature at the betrothal of Claudio and Hero. The restless nature of the actress seems to be congenial to the character of this many-sided woman; and her impetuous utterance, her swift and graceful movements are most effective in such passages as the interview with Benedick after the insult to Hero." New York Times, 14th November, 1884.


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Vellum Scabbard
Joannes Kalkoen
Amsterdam, Netherlands
about 1670
Museum no. M.60:2-1947
This is a vellum scabbard for a small sword made by Joannes Kalkoen circa 1670 in Amsterdam. The hilt of the sword is enamelled gold and the blade is inscribed 'Francisco (Ru)iz en Toleto' and bears the makers mark.
The scabbard, constructed of calfskin, has been worked over a fine wooden core. The vellum is applied in one piece and stitched on the reverse proper right side. It has a number of engraved markings towards the hilt end that were not clearly legible prior to cleaning due to a heavy coat of ingrained soil.


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on January 17, 2013 - 12:13 AM
The United Way of Buffalo & Erie County has a new resource for making decisions on what human services programs to fund.
United Way officials Tuesday released a 198-page "community needs assessment" that spells out the most critical human services issues facing local governments and agencies.
Chief among them are population loss; a growth in immigrants, including many who don't speak English; growing concentrations of aging and elderly people in the suburbs and rural areas; persistent high rates of disability, particularly in Buffalo; a large population of military veterans; poverty rates of 40 percent or more in some Buffalo neighborhoods; and much lower median, household and family income levels for the county and city, compared with the state.
Michael Weiner, United Way president and chief executive officer, called the report "voluminous" and said it will be a valuable tool for the organization and for area nonprofit human service providers.
The report is available at www.uwbec.org/needsassessment. The United Way spent about nine months and $20,000 to produce the assessment, which relied on more than 100 data sources, as well as interviews with key stakeholders and more than 30 focus groups with human service providers and local residents.
Its findings will be especially helpful as the community decides how to tackle challenges with limited resources, Weiner said.
"The reality is there are insufficient resources to address all the unmet needs out there," Weiner said.
Without establishing priorities, he said, the community won't make any progress in overcoming those needs.
email: firstname.lastname@example.com


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Source: Microsoft
quote: I think the idea of "Functional" or "Divisional" organisation is misleading, whether it is one or the other is less important than whether Microsoft is adapting to the new technology so it is keeping up or staying ahead of the competition, which it isn't.
quote: But Jobs had unequalled authority in a battered and almost despairing Apple organisation,
quote: If another Steve Jobs turned up at Apple today would he be given the same opportunities as did Steve Jobs 1? No, almost certainly not, and that is the same problem facing Ballmer: he is trying to keep a profitable company profitable, he isn't trying to bring Microsoft back from the brink of collapse.


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A new school year
Welcome back to school for 2016. As we start the year we have high expectations of our students and staff and a commitment to deliver the excellent public education that parents, carers and the community rightly demand. This year... Read more
Applications for student travel 2016
From 2 November 2015, a new online SSTS application process is being introduced for schools within the Opal network, coinciding with the introduction of the School Opal card. Schools outside the Opal network should continue to... Read more
2016 school funding allocations
All NSW public schools are currently being advised of their 2016 Resource Allocation Model (RAM) funding. RAM distributes funding based on individual needs of students and schools, and gives schools greater flexibility to make... Read more
|Our students are our focus. Ebor Public School provides a 21st Century Education in a quality learning environment, where each of our students can reach their full potential. While we learn we grow.


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Source: Reuters
quote: This is a waste of shareholder money
quote: Best thing to do when you see Tony trolling, is to downvote and ignore his post
quote: I suspect he leads a lonely, frustrated and angry existence and this forum is where he passive aggressively vents the suppressed rage.
quote: This really does point to your need to make yourself fell better about a purchase and convert others to your church of (Steve) Jobs.
quote: Tony,This is the stupidest thing you have ever said. It is so stupid that I now know with absolute certainty that nothing you say has the benefit of intelligence.Apple answers to its shareholders. The cash Apple holds? That belongs to the shareholders. If Apple actually tried to use that to survive by spending it down towards zero it would have only one result. Its share price would nose dive.Apple invulnerable? Are you so completely consumed by being a fanboi that you're THAT far gone? After ten years of losses, nobody would want Apple stock - you do not invest in something whose value is eroding. Go look at HP's and Nokia's stock for the past few years.That would prompt a shareholder revolt, the outing of the board, and a possible takeover (leveraging Apple's assets - assuming it hasn't spent them all!).
quote: Jeez - do you struggle with the concept of hypotheticals?
quote: Apple do give money back to the shareholders in the form of dividends, they may give more in the future.
quote: Jeez - why are you such a douche?
quote: And that didn't start until AFTER Jobs died as far as I am aware.
quote: differing points of view
quote: Why do people who don't much like Apple, mostly despise it's customers and who want to see Apple stumble or be beaten in the market cry crocodile tears over the poor apple shareholders denied their access to the cash mountain? Crass flatulent hypocrisy is why.
quote: iOS this year will outsell Windows and within two years iOS will have an installed base bigger than the Windows installed base.
quote: quote:iOS this year will outsell Windows and within two years iOS will have an installed base bigger than the Windows installed base.the bullshit is getting pretty deep in here.


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Monday, December 1, 2008
Mama's Pineapple Filling
Mama's Pineapple Filling
Posted at http://deepsouthdish.com/
1/2 cup of sugar
4 egg yolks
1/2 of a large can of Dole crushed pineapple
Juice of 1 lemon
1-1/2 tablespoons Land O' Lakes butter
1 tablespoons flour
Combine all ingredients and cook over medium heat until well thickened. Cool. This will thicken some when cool. Makes about 1 cup of filling; use approximately ½ cup per layer.
Leave a Comment
23 comments:
My favorite cake for all time is Coconut Cake with Pineapple Filling. Mary, do you suppose I could use your Mom's filling in a bundt cake..Like layer it between cups of batter like a coffee cake?ReplyDeleteReplies
- AnonymousJuly 27, 2015 at 4:54 PM
Toni do you have a good recipe for your Coconut Cake that I can put this pineapple filling in? Can I use a Bundt pan? My husband loves coconut cake, this might be a nice surprise for him since he loves vanilla ice cream with coconut and pineapple topping. Thank you, Evelyn B.Delete
I'm not sure Toni, but if you try it, let me know!!ReplyDelete
Just made this... It came out fabulous! I put it between layers of orange cake. Can't wait to bring it to my event tomorrow. Thanks for the recipe!ReplyDeleteReplies
You're welcome Lori!Delete
Hi Mary! I just made your pineapple cake filling. Wow is it good! Cake filling just doesn't get any better than this! The recipe made 1 and 1/2 cups for me using half of a 20 oz can of pineapple. (My eggs might have been a little bigger...) Thanks for sharing this yummy recipe. I look forward to coming back and trying more of your recipes.ReplyDelete
You're welcome Mary - thanks for stopping by and taking the time to comment!ReplyDelete
- AnonymousDecember 27, 2013 at 1:28 PM
I am slightly allergic to eggs. Can I leave them out?ReplyDeleteReplies
You can! You'll lose some of the richness that you'd get from the egg yolks though and you'd have to use a binder like cornstarch for thickening since the eggs act as a thickening agent also. Just not sure how much. I'd start with about 1-1/2 tablespoons and increase from there if needed.Delete
Oh my goodness this is the best I used to use a store brought filling from my cake supply store,at 2am ran out and frantically searched the web, came across yoir recipe. And will never ever use commercial filling again! Gotta admit I was a little skeptic initially when I reviewed the ingredients but since it was all available in my pantry and the reviews were positive I figured what would it hurt to give it a try!!! I'm forever greatful and my cake was a hit! Thanks for sharingReplyDeleteReplies
You're very welcome & I'm so glad to hear that you also enjoyed it!!Delete
- Marta roenickeMay 28, 2014 at 9:20 AM
Im going to try this for my school I take cake decorating classesReplyDeleteReplies
Oh, let us know how it is received by everybody!Delete
- AnonymousNovember 7, 2014 at 7:58 AM
Am I supposed to drain the pineapple, or use the juice too?ReplyDeleteReplies
Undrained, using the juice!Delete
Thank you again. For the Pineapple Filling. It was exactly what I was looking for. This is going to be a Super Bowl party hit! I will definitely make this again.ReplyDeleteReplies
You're welcome Wendy!Delete
How do you think this will taste will almond cake and icing?ReplyDeleteReplies
It will be great Ashley, so long as the almond is not overpowering and strong, the flavors should compliment each other. Mama used this filling on many an almond wedding cake too, but they are lightly flavored with almond extract.Delete
- AnonymousJune 21, 2015 at 3:49 PM
Can this be used as a filling for cheesecake tartsReplyDeleteReplies
I haven't used it with a tart, but it should work!! Since there aren't any cake layers involved, I would reduce the lemon by half, and drain the pineapple, but then add the drained juice a little at a time to the saucepan, for a thicker consistency.Delete
- Jean CarrJuly 21, 2016 at 6:50 PM
I was amazed to see this recipe. I have used this recipe for years.lt was passed down to me from my cousin Jean in Currituck NC.Always visiting there, l would always ask her to make me a pineapple layer cake and she shared it with me.No other fillings can touch this one.Brings back memories by ofthe ladies in the family who made this delicious cake.ReplyDelete
- AnonymousAugust 24, 2016 at 10:19 AM
First of let me say I've never left a recipe review simply bc recipes are a matter of preference. However, this filling made my night and day.took me back to my childhood. I've been craving one of those old school pineapple cakes that I remembered... you know the one that showed up to church functions and family picnics? I never knew who made the cakes but I always found them in the dessert line. After reading an assortment of recipes online (couldn't find it in ANY of my cookbooks) I came across your pineapple filling. After reading the reviews and seeing a db boiler wasn't required decided to give it a try. It didn't disappoint. Sadly, between last night and breakfast this morning, I ate a quarter of the cake. I'll hv to scale back if this is to last to the weekend :).... so glad to hv this filling in my arsenal. Thank you for sharing!
Thanks for taking the time to comment - I love hearing from readers and I read every single comment and try to respond to them right here on the site, so stop back by!
From time to time, anonymous restrictions and/or comment moderation may be activated due to comment spam. I also reserve the right to edit, delete or otherwise exercise total editorial discretion over any comments left on this blog. If your comment serves only to be snarky, mean-spirited or argumentative, it will be deleted. Please mind your manners.
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Now more than ever, we need your support! Become a Supporting Subscriber today.
Dr Who end a 'brilliant send-off' [Slight Spoiler]
The final scenes in Doctor Who are a "brilliant send-off" for David Tennant, his co-star has said.
BBC Radio 'Newsbeat' item:-
Cheers, daveac
Which one? There are a million of them


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Systemwide Events Calendar
Indigo Blues WorkshopOctober 26, 9:00am - 12:00pm
Manoa Campus, 3860 Manoa Rd.
Indigo is the universal hue of handwoven, hand-dyed and restitched fabrics.
From desert Tuareg tribes to the 14th generation of Kyoto dyers, to the manufacturers of denim jeans, indigo rules! Learn how indigo permanently dyes fabrics in this two-session class. Use resist methods of tie dye binding and clamping objects to create patterns.
Control hue intensity with multiple submersion. Historical, cultural and botanical aspects will be covered and indigo textiles will be examined. Detailed supply list and bibliography will be sent prior to the first class. Instructor: Ann Asakura, indigo dyer for 30 years. In partnership with TEMARI, Center for Asian and Pacific Arts.
Call 988-0456 to register.
Ticket Information
call 988-0456 for information
Event Sponsor
Lyon Arboretum, Manoa Campus
More Information
Jill Laughlin, 988-0456, firstname.lastname@example.com, http://www.hawaii.edu/lyonarboretum
|Saturday, October 26
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Indigo Blues Workshop
Manoa Campus, 3860 Manoa Rd.
|Plein Air Watercolor Painting Workshop
Manoa Campus, Lyon Arboretum, 3860 Manoa Rd.
|Making the Graphic Novel
Manoa Campus, Krauss Hall
|Social Media Summit & Expo
Neal S. Blaisdell Center
|2013 SOEST Open House
Manoa Campus, POST / HIG / MSB
|Manoa Maniacs Student Tailgate
Manoa Campus, Aloha Stadium
|Manoa Jazz & Heritage Festival
Manoa Campus, Orvis Auditorium
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- The Wonder of Learning: the Hundred Languages of Children Exhibit
- Waikiki Parc Features Nicole Naone
- Course Reserves Deadlines and Information
- Red Hat System Administration I
- EWC Arts Exhibition: Bollywood & Beyond: Costume in Indian Film
- Kalaupapa -- A Source of Light, Constant and Never-Fading
- Trip Around the Island
- Convergence: Glitch_Click_Thunk, Featuring Mark Amerika
- Trip Around the Island exhibit
- Conflict Resolution Day Book Displays
- UHM Costume Museum Exihibition
- The Wild Party


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This is exactly what I am looking for in a travel book. Frazier does an excellent job in combining extensive historical research and personal travel details and interweaves them into an immensely enjoyable book. Ignore the fact that Travels in Siberia is about 600 pages long, and travels to someplace you may never get to or wish to visit.
Frazier spent several years and several trips to various parts of Siberia, and this remains the main focus of this book. The engaging factor is that none of these are just trips, and he allows for the Russian Far East to become part of his life, his passion. Supplementing the daily details of the trips, including what they ate, where they camped, what they wore, and how they suffered the army of mosquitoes, is a rich history of Siberia and the overall international implications that stem from that vast region.


text:
Pet Lovers Upright Value Kit
Sku # CLPK08
Everything you need to clean stubborn stains and pet smells.
- 8 Odor Fighting Vacuum Bags (CCPK8OF)– filtration technology uses activated charcoal to fight odors.
- 12 Handheld Vacuum Bags (PKBB12DW) – double-wall vacuum bags with one micro-filter.
- 12 pack of Fresh Air Tabs (AIRTABS) – Freshens the air every time you use your vacuum cleaner - simply place one in your vacuum bag and vacuum.
- 1 Drive Belt (75024-01) – Fits most Oreck Upright models.
- 1 container of Crystal Aroma II® (AROMAII) – Refreshes carpets and rooms while you vacuum.
- 1 bottle of No Return® Pet Odor & Pet Stain Remover (38173) – Works great on stains and odors.
- A $97 value, you pay just $69.99. A 28% savings.
Kit contents not for use with Magnesium, Edge Models or Oreck Halo
out of stock
Related Products


text:
Scientific Publications
< Back to Publications
Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3
|Publication Type
|Journal Article
|Carmody, LC, Germain A., Barker D., Galan-Rodriguez C., Bettiol E., Rodriguez A., Macpherson L., Palmer M., and Schreiber SL
|Chagas disease is a tropical disease caused by the parasite Trypanosoma cruzi (T. cruzi), which is endemic to Central and South America. Approximately 13 million people are infected with the parasite, and 25–30% of infected patients suffer from irreversible damage to the heart and digestive tract resulting in disability and death within 20 years of infection. Few treatments are available with limited effectiveness only against the early (acute) stages of disease, significant toxicity, and widespread drug resistance. We report the outcome of a high-throughput chemical library screen to identify novel, nontoxic, small-molecule inhibitors of T. cruzi, which will aid the development of more potent and selective therapies for both the acute and chronic stages of Chagas disease. Of the 303,224-screened compounds, 35 compounds were chosen based on their selectivity, potency, and chemical tractability. Of those, 27 dry powder-validated compounds were retested in the primary screen, secondary assays, and an orthogonal screen. Three scaffolds were prioritized to identify potential probes. One of these compounds (CID3238551/ML158) displayed greater than 100-fold selective inhibition of T. cruzi confirmed in immunofluorescent imaging assays and is inactive against host cells at the highest tested dose. This new probe should be very useful in future cell-based investigations and in vivo studies of T. cruzi inhibition.
|Year of Publication
|Date Published (YYYY/MM/DD)


text:
Source: The Detroit News
quote: Also what I don't see here is any remedy for real world interference. That one signal that your car misses due to a lightning strike at the right moment and you don't slow down in time.
quote: nuclear power
quote: airliners
quote: You realize with automated traffic the traffic jam wouldn't form to begin with right?
quote: You think the minor issues with an automated road would be any worse than what we've got?


text:
Valera Swiss Nano Dryer Diffuser
We're sorry, this product is no longer available.
Create volume and a variety of styles with the Valera Swiss Nano Dryer Diffuser specifically made for the Valera Swiss Nano dryer.
Oct 23, 2013
Love The Dryer.
I bought the smaller red Valera in Germany as I travel quite often to Europe and didn't want to deal with the issue of watts, plug etc. The dryer has a large barrel and doesn't quite fit my hot sock though I make it fit :-). I was happy to see that it had its own diffuser as there are none that fit it. It is smaller than a normal size one but not that small. I have short hair so it works great.
Maybe the prior reviewer should have purchased the larger Valera with the long barrel which fits a variety of diffusers. (This is a very light dryer, unlike the smaller dryer mentioned above) I bought this one recently to use in the US and am using my babylis portofino diffuser with it.
What's also nice is that this diffuser has small holes unlike many of the cheaper diffusers that blow your hair all over as if it wasn't there.
1 out of 2 shoppers thought this review was helpful.
Chicago, IL
Dec 5, 2012
Seriously. Seriously? I Mean, Seriously....
I'm gonna go ahead and assume that either this diffuser was designed by men who have no experience with hair, or women that have neither long nor even remotely wavy hair thus never needing to use this cruel joke of a diffuser. It's sad bc i love the Valero. The whole reason i set out to replace my old blow dryer in the first place was so that i could by one with a diffuser. This diffuser is teeny tiny and cup/bowl thingy is like 1/4 an inch deep (okay so that's an exaggeration but it's VERY shallow and the diameter of the diffuser is very small!). But what ISN'T an exaggeration is the fact that whenever i use it (and yes i still do bc i missed the window of opportunity to return it and i sort of refuse to replace the blow dryer bc i love it) is the fact that bc only such a small (and i mean small) amount of your hair can fit in the cup of the diffuser at a time, the hair that surrounds it easily can get sucked up and stuck in the blow dryer! My hair like bust length but since both the blow dryer and diffuser are pretty small, it can easily happen if your hair is shorter than mine. Bottom line....EPIC FAIL Valero. Had the opportunity to make your stellar product even more stellar with an amazing diffuser and what a huge disappointment. Had i known then what i know now, i would have bought a different blow dryer that at least would have allowed me to use a quasi decent diffuser.
2 out of 3 shoppers thought this review was helpful.


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Consumers will tend to hold off their purchases if there is a new and significantly improved model coming soon. This is particularly true for electronics and automobiles. Word of the third generation Prius has been known as far back as 2006, and while the economic downturn played a significant role in cutting sales of the older Prius, the waiting game may have had a larger impact than previously thought.
Toyota had already decided to increase production of the Prius to 600,000 units per year in late May after seeing huge sales in Japan. The company has had to begin weekend production of the Prius in order to make a dent in demand. Increases in fuel economy and horsepower had led many to delay their purchases of the Prius until the 2010 model was available. However, many potential customers also switched to Honda's Insight hybrid, which topped the Japanese sales charts in April.
In the two months since, hybrids have continued their sales dominance, with the 2010 Toyota Prius and Honda Insight both posting strong sales. The Toyota Prius seized the top spot in May, with sales of 10,915 cars.
This month, though, it set an even more impressive mark, becoming the first hybrid in Japan's history to outsell all other vehicles. The Honda Insight's previous sales record had excluded popular mini-vehicles with engines of up to 660cc. Those mini-vehicles were easily outsold by the Prius, thanks to sales of 22,292 units.
Honda continued to do well, with its Insight Hybrid coming in fourth place. Honda's Fit, a fuel efficient traditional offering came in second place, with 13,016 vehicles sold. The sales of Toyota and Honda's hybrids were helped by relatively high worldwide gas prices, which drove Japanese consumers to take fuel economy more seriously. Japanese tax breaks have also helped convince users to switch to hybrids.
Hybrid vehicles have yet to crack the top of U.S. sales charts, but some believe it's only a matter of time before a foreign hybrid like the Toyota Prius, or a domestic like the Ford Fusion pushes towards the top.
All of this bodes well for those hoping of a restart of Toyota's $1.3 billion Prius assembly plant currently under construction in Blue Springs, Mississippi. Toyota has already spent over $300 million on the plant. The building shell itself is finished, but the tooling and production machinery will be installed at a later date. Parts suppliers have also halted building expansion and tooling operations until Toyota commits to a restart date.
The case for a restart is particularly strong since New United Motor Manufacturing Inc. (NUMMI) appears destined for a shutdown. The joint venture between Toyota and General Motors will cease to produce the Pontiac Vibe, which is based on Toyota's Matrix. It also produces the popular Toyota Corolla and Toyota's Tacoma truck, production which could shift to Blue Springs. Production of the Toyota Yaris hybrid is also a possibility.
quote: And who's going to touch these used? $3k for the car and $5k for batteries?
quote: The specs I've seen from manufacturers are about 7 years for the battery
quote: Why? Because it is a guaranteed failure item within the warranty period that exceeds this "profit" that is being trumpeted. There is no prediction involved, it is going to happen. The specs I've seen from manufacturers are about 7 years for the battery. And hybrids will also be no better than a conventional car in regards to suspension components or transmissions. So you have all the normal maintenance with a second driveline and batteries added on top of it. And who's going to touch these used? $3k for the car and $5k for batteries?