text:
Each week The New Yorker has a caption contest at the back of the magazine. Readers can submit an idea for a caption online that would accompany a quirky cartoon drawn by one of the magazine's cartoonists.
Members of the editorial staff then sort through what must be thousands of potential captions and narrow them down to three, which are then put to an online vote so readers can determine their favorite.
The winner is acknowledged as such in a subsequent issue and receives an autographed original of the cartoon with the appropriately credited caption.
Since brevity is the soul of wit, winning captions are invariably witty and brief. I've submitted several entries over the past few years and haven't even made the final three. Either I haven't found the formula or my captions just aren't very good, or both.
Take the most recent contest I entered last month. The cartoon shows a scene inside a funeral home. The deceased is lying in quiet repose for an open viewing while a couple in mourning stands alongside paying their respects.
Both are wearing sunglasses, and she is seen to be quietly murmuring something as he gently places a reassuring hand behind her shoulder. The twist is that an IV line is found sneaking out of the casket where it is attached to a bag of fluid suspended from an IV pole. What's the caption?
Well, I wrote down a couple of things, including "He always was a bit of a drip." I'll submit that, I thought. Why not? It's brief, witty (maybe), with a touch of curmudgeonly irony, and even has a certain metric rhythm.
The editorial staff wasn't impressed. Their top three choices were, "We'll eventually miss him," "He never could commit" and "He had great health insurance."
Readers will have determined their favorite by the time you read this, though if you went online, you might have found at least one write-in vote. Hmm, I wonder whose that was? (Just kidding, no write-ins allowed.)
And in the humor department, did you hear the one about the fellow who went to his doctor and asked if he'd live to be 100 by giving up liquor, tobacco products, red meat and sex? "No," the doctor replied, "but it will certainly feel like it."
The piece here a couple of weeks ago about the old county library building generated lots of response. Interestingly, none of the letters I received stood up for the bedraggled structure, although one defending the old library did run on the editorial page several days ago. Here's a sampling of the commentary:
Jenny Bevan, of the architectural firm Bevan and Liberatos, whose presentation inspired my remarks, says, "The library's preservation worthiness is a 'hot' and complex topic and you managed to address the issue with both depth and grace.
"Even though our local preservation ordinance is guided by the tradition and the national standards descend from international modernist manifestos, it is the national standards which now guide the Preservation Society. It is endlessly frustrating to see Charleston's local culture usurped by the fashions of international preservation. The inability of the national preservation standards to reconcile with a community's local culture is their main failure and the cause of much contradiction in the minds of those preservationists who love old buildings and are being taught that we ought not build them anymore."
The Rev. Brian McGreevy, Porter-Gaud's school chaplain and a member of the clergy at St. Philip's Church, knows a thing or two about preservation, having worked in a previous life for the Historic Charleston Foundation, the National Trust and the Georgia Trust for Historic Preservation. He also participated with the International Council on Monuments and Sites and Les Vieilles Maisons Francaises.
He writes (in part), "It has been a source of increasing dismay to me to see the architectural community in Charleston falling slavishly in line with the flawed tenets of modernism ... I feel that I have at least a clue about this topic, and it is truly dismay-ing to see the priceless ambiance of Charleston being tawdried by these intrusions."
In addition to "unfortunate older structures" such as the former county library, the writer cites the Jewish Studies Center at the College of Charleston and the "horrific proposed Clemson Center" as among "the new blights on the city."
J. Addison Ingle Jr. gets in a good-natured and all-too-accurate jab: "May I take you to task for poor punctuation? Late in your article you said: 'and you have a modernist structure that belongs ... well, outside the Historic District.' I am SURE that you meant to say, '... a modernist structure that belongs well outside the Historic District.'
Here's an amusing vignette from Dave Fortiere. "My wife, nee Nancy Siegling, tells me an anecdote related to the library. She was attending a Junior League function downtown about the time the library was built, and the subject of it came up in conversation. Her comments and observations were very much like yours, but then it was pointed out that the architect's wife was standing right next to her and overheard everything. It was nearly the end of her Junior League experience."
Edward M. Gilbreth is a Charleston physician. Reach him at edwardgilbreth@ comcast.net.

subset: commoncrawl


text:
Lindsay Lohan through the years
POSTED: 2:20 PM PDT May 25, 2011 UPDATED: 9:39 PM PDT July 3, 2014
Take a look at the life of one-time child star turned troubled actress Lindsay Lohan, both on screen and off.
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text:
Top Definition
Best f***ing player in the whole world, excpet nobody, he is the be all and end all and we should all bow down to him and worship the ground he walks on
Oh wow-theres Thierry Henry, lets kiss the floor where he justed stepped
dari fruit fly Sabtu, 12 Maret 2005
Trending Now
Can you define these popular missing words?
Thierry Henry - Simply one of the best players in the world at the minute. Maybe the best actor too. Nice guy too, leads the anti-racism campaign like a true champion.
Hey, did you see Thierry Henry last night? Scored 4 and set up 5. I can't believe people compare this guy to Nistelrooy...
dari Thierry Henry Sabtu, 12 Maret 2005
A French Footballer who also plays for Arsenal. He is also the best soccer player in the world right now. Hat Trick today against Bayern Munich.
I hope someday I will be as good as Thierry Henry
dari Jonathan Sabtu, 05 Maret 2005
equal GOD !!! F***ing magic player! Only One In The WORLD !The Best Striker in whole universe.Play For Arsenal <-> FOREVER IN UOR HEARTS !
if somebody says bad things about Tel i`ll find and KILL HIM !
dari Bulgarian Gooner Kamis, 07 April 2005
Deffinately the best striker to play football ever. He scores a lot of goals. He plays for Arsenal and is French.
Did you see Thierry Henry's goal last night? It was amazing!!
dari Ur Maw Sabtu, 09 Juni 2007
To be called Thierry Henry is to be called a cheating french scumbag in Ireland.
You'r a filthy Thierry Henry.
dari DerangedAngel Jumat, 20 November 2009
1. Arsenal FC's top goal-scorer for the past eight years. He is said to be Europe's greatest striker marked with sheer clinical finishing abilities and uncanny intelligence on the field.
2. See traitor.
2. See traitor.
Thierry Henry and Patrick Vieira (also see traitor) are French scum who've turned their back on Arsenal. Arsene Wenger will be the latter.


text:
Joint Extreme is an all-natural product containing naturally occurring glycosaminoglycans and essential proteins for pain relief and joint support. Joint Extreme contains NEM®' Natural Eggshell Membrane' a dietary supplement that promotes healthy connective tissue health. This ingredient is essential for athletes and others who may suffer from joint pain or distress.
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Serving Size: 1 Vegetable Capsule
Servings Per Container: 30
Amount Per Serving / % DV*
NEM® Eggshell membrane 500mg / *
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Other Ingredients: Vegetable capsule (vegetable cellulose)' rice flour' vegetable powder' silica.
Contains no: Added salt' colorings or preservatives. Free of dairy' gluten' soy' fish' tree nuts' peanuts' wheat and artificial ingredients.
Contains Egg derivatives.
As a dietary supplement' take 1 capsule two times per day until results occur' then take 1 capsule once per day or as needed with a full glass of water.
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text: Journalist Geraldo Rivera has been a television fixture for more than 40 years. At age 71, he shows no signs of slowing down. 'Oprah: Where Are They Now?' cameras recently did their best to keep up with him during a typical workday, including lunch with his wife of 10 years, Erica. Though he has admitted to cheating on his previous four wives, Geraldo says he has been completely faithful to Erica. Watch as the couple reflects on the strength of their relationship. (Photo Credit: Getty)


text:
City Performance Hall architecture
Photo: Mona Reeder/Staff Photographer
The lobby's exterior glass wall reflects neighboring buildings downtown.
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text:
Paula Deen embroiled in buttery brouhaha
June 27, 2013
In a large mixing bowl, add a pound of ground beef, an egg, a half cup of bread crumbs, a pinch of salt, a dash of pepper, a pound or two of butter and — of course — a smattering of racial slurs and......
I would actually vote for a democrat if there were such a thing as a functioning brain inside any of them. Geez...dumber than dirt.
3 Agrees | 0 Disagrees | Report Abuse »
I have to disagree with you truthseeker, they are not finished...too many people in this country see nothing wrong with what is going on...
4 Agrees | 2 Disagrees | Report Abuse »
Liberals are so funny. They can't keep up with their own lies. Democrats are failing in so many ways. Their party is destroyed from within; and they keep opening their mouths and showing us their racist ways, their lying mouths, their attempts to steal what is not theirs. They are finished. They are a disgusting bunch of go-nowheres that fail in everything they touch. The world finds them useless and dispicable people. Disgusting little leeches.
3 Agrees | 0 Disagrees | Report Abuse »
I still find it amusing that the only folks who can use the so called "N" word are the, let me get this correct, "African Americans". The media, government and lawyers fuel so called race card. For example. African Americans make up roughly 13% according to the 2012 census. A group of 12 non winning contestants of American Idol are suing the show for $25 million each claiming discrimination. Yet, depending on the year of the show, the panel of judges is between 25% and 75%. In the 12 years the show has been on, 4 of the 12 winners have been black, 33%. But now the race mongers are trying to make something out of nothing just to make some money. Suffice it to say, none of the people stirring this pot were ever a slave...so get over it.
6 Agrees | 0 Disagrees | Report Abuse »
Of course with these crazy conservatives here, this would devolve into a discussion about the Obama administration.
Anyway, let's not forget that in addition to using the N-word, she wanted to have a true "Southern plantation-style theme[d]" wedding, with black servers and all. Are you kidding me?
0 Agrees | 6 Disagrees | Report Abuse »
Bwahaha......leftwing nuts can't even defend their own insanity. But its' funny to watch. What ignorance and outright lies they keep telling, one after the other, hilariously trying to cover up one lie with half a dozen other laughable excuses and lies. Liberalism is a chronic disease that causes the brain to not mature. Like watching 5 year olds. lol.
3 Agrees | 2 Disagrees | Report Abuse »
it's so sad that everything that happens in the world is Obama fault . The Paula Dean story is simply an old white woman from the south being defended by alot of people for something she openly admitted of using the N word by her own admission freely and with no filter. She stated that in her depostion nobody made her say anything but now everyone wants to come to rescue and divert attention on what she said. If you have ever been to the deep south you know how it is. They still are fighting the civil war again and again hoping one day the south will rise again. It sad how people especailly white people want to say it's ok to say those kinda things to people.
2 Agrees | 7 Disagrees | Report Abuse »
Paula Dean fits the left's description of an enemy. She's white, aging, conservative Christian woman with a prosperous business. Dean is the epitome of the type of person the Obama administration loves to target. I noticed there isn't one reply from the leftwing zealots that usually hang out in here. Perhaps they're avoiding this article since they have been called out and are too cowardly to admit they are just as guilty as Dean when it comes to making racial comments or passing around jokes with racial undertones. They know the attacks on Dean are nothing more than politically motivated attacks on white, successful Americans. The same attacks that have been going on since Obama took office. I wonder how many times Elkins has been guilty of making racial slurs or laughed when someone told a racist joke? Not one of them have a clear conscience on this one.
3 Agrees | 2 Disagrees | Report Abuse »
The left "stealing" what others have and USING racism to do it. THAT is what this is about.
Obama and Eric Holder have been using the office of the DOJ and the Oval Office for these dirty deeds for 5 years as they only go after business owners whom refuses to bow down to their socialist agenda.
3 Agrees | 2 Disagrees | Report Abuse »
Obviously elkins....you aren't capable of 'comprehending' what you read. Paula always did "own it" as you liberally put it. UNLIKE the democrats who are the racists.....like now deceased Robert Byrd, KKK life member who you libs like to 'ignore' as having been worse than Paula Deen.....conservatives admit when they're wrong, but dems don't and they get a pass. The left are hypocrites, bigots, racists, and they keep 'proving' this over and over. Elkins....wondering how fast I can track down last time YOU used an off color joke, told it or heard it and laughed, passed it on through your email to your friends. Yep; you'd be lying if you said YOU never told or laughed or participated in a joke that mocked, laughed at someone else whether, a blonde joke, a black joke, a polish joke, etc.....
Can't wait till the people who are now obviously searching...find those racist words used by them. Watch out Matt Lauer, Katie Couric, Elkins26241...and you other 'hypocrites' who throw ston
3 Agrees | 2 Disagrees | Report Abuse »
It's funny that Paula Dean makes a statement under oath and now it's someone elses fault that she feels so comfortable using that word no one ever made her say anything she chose to. She is an old school biggot from the deep south now she just needs to own it
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text:
Top Definition
Gurl or Guy Who Dont Leave You Alone.
Callin You Up Every Two Minutes On Your Celly, and Just Dont Trust You Doin Nothin, You Say Your Out Wit Your Boiz And She Thinks Your Out Creepin With Some Other Trick.
作者 :::eQuatZ::: 2003年2月21日
Trending Now
Can you define these popular missing words?
overly annoying person that constantly calls or goes to your home uninvited.
Jeremy L. is such a bugaboo!
作者 sexqueen 2003年7月11日
Someone who is clingy and blows up your cellphone.
(Phone Rings @ 4am in the morning) I'm not answering that, it's that bug-a-boo again.
作者 Nyesha 2006年8月02日
An annoying stalkerish person who won't leave you alone.
Chick1:"Girl, your text tone keeps ringing off the wall!"
Chick2:"I know! Ugh, its this stupid bug a boo that won't leave me alone!"
Chick2:"I know! Ugh, its this stupid bug a boo that won't leave me alone!"
作者 Mario! 2009年4月05日
bugaboo: noun. Clingy; blows up your cellphone, hijacks every facebook/myspace/twitter posting, coffee break, lunch hour, down time, and instant messaging moment of opportunity to the point of suffication, and sucking every miniscule amount of time and breathe you own thus inducing the need for separtation, and official string cutting ceremony.
clingy pest cling-on freak nuisance stalker
clingy pest cling-on freak nuisance stalker
ie: "I can't believe that he/she thinks I need to spend every dang second of the day with him/her! A deserted island right now would be like winning the mega million powerball prize!! *gasps for air* HELP I CANT BREATHE, MAKE THAT BUGABOO GO AWAY!!!"
作者 MonkeyGirl75 2009年8月05日
A silly, affection term used to address close friends.
Goodnight, bugaboo. See you soon
作者 Frankie001 2011年8月01日
An unfortunate event that occurs when you accidentally sit on your penis, and the tip pokes you in your butt.
Joe received his first bugaboo this morning. He's not having a good day.
作者 JoesPoliceRecord 2012年1月22日


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Elizabeth Anne Rhoads, Woolrich, and Bradley Mark Greenaway, Jersey Shore, were united in marriage at 3:30 p.m. Saturday, Aug. 4, 2012.
The Revs. Cathy Dawes and Jim VanZandt officiated at the ceremony held at Phelps Chapel, Jersey Shore.
A French country reception was held at the Williamsport Country Club.
Article Photos
(Elizabeth Anne Rhoads)
The bride is the daughter of Anne and Gary Rhoads, Woolrich. She graduated from Central Mountain High School, Mill Hall in 2005 and received a bachelor's degree in communications from Susquehanna University, Selinsgrove, in 2009. She is employed by Lycoming College as a web content coordinator.
Greenaway is the son of Lori and Timothy Greenaway, Jersey Shore. He graduated from Jersey Shore Area High School in 2004 and received a bachelor's degree in civil engineering from Penn State University in 2008. He is employed by Larson Design Group as a bridge designer.
Maid of honor was Juliana Knight, cousin of the bride.
Bridesmaids were Kari and Katie Greenaway, both sisters of the bridegroom; Marie Dortone and Laurie Decker.
Best man was Daniel Greenaway, brother of the bridegroom.
Groomsmen were Andrew Rhoads, brother of the bride; Jordan Allison; Michael Griggs; and Christopher Grove.
Flower girl was Gwen Stamps, second cousin of the bride.
Ring bearer was Cole Stamps, second cousin of the bride.
Following a trip to St. Lucia, the couple is residing in Montoursville.


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"product met expectations." (E13157)
"cute - they love it!" (E473)
"Extremely nice medal I am trying to find a sponsor to purchase them for my soccer team since they went undefeated this season.
I love the different ribbon choices because there is the ultimate ribbon that matches our team colors perefectly!!!" (E4260)
Epic Sports
High Five SINGLE LAYER Reversible Soccer Jerseys [E113]


text:
Balloon Endoscopy Center - Prescott Valley, AZ
- WebMD Physician Directory of Prescott Valley Gastroenterologist Doctors
- Related Balloon Endoscopy Articles
- Prescott Valley Emergency Contacts
- Nearby Prescott Valley Hospitals
- Find a Local Pharmacy on RxList - Prescott Valley
Prescott Valley Gastroenterologist Doctors for Balloon Endoscopy
Type of Physician: Gastroenterologist
What is a Gastroenterologist? A subspecialty certification by the Board of Internal Medicine; practitioners focus on the stomach, intestines, colon, liver, and gallbladder (digestive organs). The gastroenterologist treats conditions such as abdominal pain, ulcers, diarrhea, cancer, and jaundice and they consult with surgeons when abdominal operations are indicated.
Specialty: Gastroenterology
Common Name: GI Doctor
Gastroenterologist Doctors in Prescott Valley * results
- 2
Richard Pleva
Digestive Disease Specialists
5350 Distinction Way
Prescott, AZ 86301
(928) 445-4066
- 25 years experience
- 1 office location(s)
- 3
Ching Wang
Digestive Disease Specialists
5350 Distinction Way
Prescott, AZ 86301
(928) 445-4066
- 26 years experience
- 2 office location(s)
- 4
Shayan Alam
Physician Care Gastroenterology
811 Ainsworth Dr Ste 103
Prescott, AZ 86301
(928) 771-5548
- 10 years experience
- 1 office location(s)
- 5
Mark T. Worthington
Physician Care Gastroenterology
811 Ainsworth Dr Ste 103
Prescott, AZ 86301
(928) 771-5548
- 28 years experience
- 1 office location(s)
- 6
Peter Witt
Physician Care Gastroenterology
811 Ainsworth Dr Ste 103
Prescott, AZ 86301
(928) 771-5548
- 1 office location(s)
- 7
Juan C. Teran
Verde Valley Medical Center
294 W State Route 89a Ste 213
Cottonwood, AZ 86326
(928) 649-7913
- 1 office location(s)
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Balloon Endoscopy
Introduction to endoscopy
The use of upper and lower gastrointestinal endoscopes has revolutionized the diagnosis and treatment of diseases of the esophagus, stomach, duodenum, and colon (large intestine). The last remaining frontier in ...
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Emergency Contact for Prescott Valley
- In case of Emergency, call 911
Nearby Prescott Valley Hospitals results
- 1Yavapai Reg Med Ctr East Hosp
7700 E Florentine Rd
Prescott Valley, Arizona 86314
(928) 445-270
- 2Northern Arizona VA Medical Ctr
500 N State Route 89
Prescott Valley, Arizona 86313
(928) 445-486
- 3Yavapai Regional Med Ctr West
1003 Willow Creek Rd
Prescott Valley, Arizona 86301
(928) 445-270
- 4Verde Valley Medical Center
269 S Candy Ln
Prescott Valley, Arizona 86326
(928) 634-225
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text:
Mandela's casket was lowered into the earth after military pallbearers carried it to the family gravesite in the rolling hills of Qunu, the rural village in eastern South Africa, which was the childhood home of the anti-apartheid leader who became the country's first democratically-elected president.
Banyanda Nyengule, head of the Nelson Mandela Museum in Mthatha and Qunu, was one of the eyewitnesses to the private burial and said it hit him hard.
"I realized that the old man is no more, no more with us you know," Nyengule said. "The moment when the coffin went down into the ground I felt too ... emotional."
South African television showed Mandela's casket at the family gravesite, but the broadcast went to a different scene just before the coffin was lowered at the request of the Mandela family.
It was South Africa's final goodbye to the man who reconciled the country in its most volatile period.
Several hundred people attended the burial. Earlier, more than 4,000, some singing and dancing, gathered for a funeral service in a huge tent at the family compound of Mandela, who died on Dec. 5 at the age of 95 after a long illness.
They sang the national anthem in an emotional rendition in which some mourners placed fists over their chests.
Elmond Jiyane / AP
Tradition and MourningMandela's portrait looked over the assembly in the white tent from behind a bank of 95 candles representing each year of his remarkable life. His casket, transported to the tent on a gun carriage and draped in the national flag, rested on a carpet of cow skins below a lectern where speakers delivered eulogies.
"A great tree has fallen, he is now going home to rest with his forefathers," said Chief Ngangomhlaba Matanzima, a representative of Mandela's family who wore an animal skin. "We thank them for lending us such an icon."
The tent ceremony was broadcast on big screens in the area, including at one spot on a hill overlooking Mandela's property. Several hundred people gathered there, some wearing the black, yellow and green colors of the African National Congress – the liberation movement-turned political party that Mandela had led – and occasionally breaking into song.
A Humble LifeNandi Mandela said her grandfather went barefoot to school in Qunu when he was boy and eventually became president and a figure of global import.
"It is to each of us to achieve anything you want in life," she said, recalling kind gestures by Mandela "that made all those around him also want to do good."
In the Xhosa language, she referred to her grandfather by his clan name: "Go well, Madiba. Go well to the land of our ancestors, you have run your race."
Ahmed Kathrada, an anti-apartheid activist who was jailed on Robben Island with Mandela, remembered his old friend's "abundant reserves" of love, patience and tolerance. He said it was painful when he saw Mandela for the last time, months ago in his hospital bed.
"He tightly held my hand, it was profoundly heartbreaking," Kathrada said, his voice breaking at times. "How I wish I never had to confront what I saw. I first met him 67 years ago and I recall the tall, healthy strong man, the boxer, the prisoner who easily wielded the pick and shovel when we couldn't do so."
Some mourners wiped away tears as Kathrada spoke, his voice trembling with emotion.
Felix Dlangamandla / REX USA
Final GoodbyeMandela's widow, Grace Machel, and his second wife, Winnie Madikizela-Mandela, were dressed in black Xhosa headwraps and dresses. Guests included veterans of the military wing of the African National Congress as well as United States Ambassador Patrick Gaspard and other foreign envoys.
Britain's Prince Charles, Monaco's Prince Albert II, Oprah Winfrey, billionaire businessman Richard Branson and former Zimbabwean Prime Minister Morgan Tsvangirai were also there.
South African honor guards from the army, navy and air force marched in formation amid rolling green hills dotted with small dwellings and neatly demarcated plots of farmland. Clouds cast shadows over the landscape.
The burial ended 10 days of mourning ceremonies that included a massive stadium memorial and three days during which Mandela's body lay in state in the capital, Pretoria.
On Saturday, Mandela's coffin was flown to Mthatha, and mourners lined the streets leading from the airport to the village of Qunu.
The burial plot on the grounds of Mandela's home had been specially prepared for him, alongside the graves of family members. He was buried at midday, amid the hills where he'd run and played as a child.
In the final benediction, shortly before Mandela's casket was lowered into the earth, the chaplain general of the South African military, Brigadier General Monwabisi Jamangile said: "Yours was truly a long walk to freedom and now you have achieved the ultimate freedom in the bosom of your maker, God almighty. Amen."


text:
Baseball Player Boyfriend Of First Out Bi College Football Player, Comes Out
Last week Conner Mertens, a football player at Willamette University in Washington, came out, making him the first active college football player to come out as bisexual.
Well, it doesn't appear that he'll be lonely now that his boyfriend, Chandler Whitney (pictured, below), a baseball player at Walla Walla Community College has also decided to come out of the closet!
Chandler tells Outsports:
"I'd been planning to do it at some point anyway," Whitney told Outsports, "and seeing the reaction to Conner's story calmed me down."
Last week when the baseball team gathered for the first practices of the new year, talk turned to stories from winter break. Because he'd spent much of the break with Mertens, Whitney felt the time was now. He stood up in front of the team, said he had contemplated whether to tell them a secret or not, and shared a "confession" he'd been holding back from them since they first met:
"I'm gay."
The team broke into spontaneous applause. It took Whitney off-guard.
"Being where I am in eastern Washington, it's not the response I expected. I'm in Walla Walla, there's not a lot of open-mindedness on the surface."
"I didn't necessarily expect hostility, but I expected a guy or two to feel uncomfortable or awkward. Everyone on the team shook my hand, gave me a hug and said we're a family and they had my back. The guys I thought would feel the most uncomfortable said don't worry about a thing, it's not a big deal."
Big congrats to Chandler (and Conner) for coming out! And we've also got to applaud his teammates for being open-minded and accepting!
It's great to see and it must be a comfort for many athletes that are considering coming out.
My name is Lorna Harmon, and I base in USA...My life is back!!! After 2 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end i almost committed suicide, i was emotionally down for a very long time. Thanks to a spell caster called Dr PETER, which i met online. On one faithful day, as I was browsing through the internet,I came across allot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. i also come across one particular testimony,it was about a woman called Sonia,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr PETER e-mail address. After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48hours, my husband came back to me. We solved our issues, and we are even happier than before Dr PETER, is really a gifted man and i will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. Try firstname.lastname@example.com anytime, he might be the answer to your problems. Here's his Dr firstname.lastname@example.com or call him on +2347055620537
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It's been my experience that guys who announce that they are 'coming out' because 'they like dudes' are not bi at all, just scared to fully admit being gay. Sadly it makes the poor kid sound undereducated by calling himself bi because he likes dudes. When I was young and figuring things out I actually made use of the dictionary. More of our youth should do the same. (And quite a few adults as well!)
When I read this article (on my iPhone) last night it said that he was gay. By the time I got to it on my computer today where I could more easily comment, you'd changed it to say he's bi. I'd just like to say, thank you for fixing it when the mistake was pointed out. Not nearly enough people do that.
Please edit this article. Mertens came out as bisexual. Bisexual is NOT gay. This type of inaccurate journalism marginalizes bisexual people. We bisexual people have a higher suicide rate than our gay peers and are far less likely to come out due to the fact that few people accept or understand us. We are our own distinct orientation and are not to be lumped in with the gays (no offense to gay people).
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Like most of the comments below why keeps yourself anonymous are you afraid that you are gay and just want to be a smart ass and play with peoples emotions? or afraid of what people might do to you? either way your comments need to be keep to yourself. People are aloud to do what they want! You must be from Westboro Baptist Church..... those stupid can just fall off the face of the earth and everyone would be better, with their cult family values.
It is most people with "anonymous" comments, as this, we one day find in the news being charged with child molestation charges, wife beating, parent abuse, etc.... its part of their ritual of cleansing themselves by chastising others... do yourself a favor and just turn yourself in before anyone gets hurt... thank you.... :) Peace out... :)
It's a great thing when young people can come out and not have negative consequences. Things have really changed. I am very happy for them. Hopefully, this will start a trend, and society will start changing more quickly.
Now all we need to do is convince Congress that we need protection in the workplace, and we will have it made.
Just because it's a smaller college doesn't make it better or worse. Who cares what size the college is? That's not the point. The point IS he came out and was accepted, then his boyfriend, who goes to a different school came out, and they announced they were together. Why not be happy for them? I am. I sure as hell wish I could have came out in school and at that age! I'm happy for the couple. And why are some of you so negative? Maybe because your hot happy with yourselves? I know a LOT of gay guys who can't stand to see 2 people having a relationship and being happy in it and some of the time they try and sabotage it. Why....because they're so miserable they can't be happy for anyone else. Get over it already. These are great young, athletic men who will be able to help others come out, and one's who will give the one's who are being bullied somebody to look up to!


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Top Definition
The Great Prophet Zarquon was a galactic prophet from ancient times, and was thought to be revered throughout the galaxy. He had scores of followers and disciples who waited diligently for an event they called "The Second Coming of the Great Prophet Zarquon". Unfortunately the prophet's lack of punctuality caused this event to happen only merely a few brief seconds before the end of the Universe itself, during which time he was able to utter only the words "Sorry I'm late..." before the universe ended. From the Douglas Adams novel "The Restaurant at the End of the Universe."
More recently, modern Galactic races use the name Zarquon as a curse word.
More recently, modern Galactic races use the name Zarquon as a curse word.
"Holy Zarquon, this zarking army is about to invade my home planet. Zark all of you zarking zarks, I won't come quietly!"
by spankypdx November 09, 2006
Trending Now
Can you define these popular missing words?
Intergalactical swearword with some religious significance and used by all intellectual species known throughout space, derived from the legendary prophet Zarquon.
Oh, Zarquon, What in the name of zarking fardwarks, For Zark's sake, Holy Zarquon's Singing Fish.
by Sebastian Viklund Åsberg December 09, 2005
Swearword derived from the prophet Great Zarquon
Great Zarquon!
by ruther July 08, 2003
The Great Prophet Zarquon, A god from Douglas Adams, Hitch Hikers guide to the Galaxy. The whole of all the know entirety was said to have come from his left nortril
"You ain't goin no further Bitch, Only Zarquon gonna save you now!"
"Holy Zarquon Singing Fish"
"What the Zarquon have you been"
"Holy Zarquon Singing Fish"
"What the Zarquon have you been"
by Ztary December 16, 2008


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Top Definition
arguably the most infuriatingly arrogant animal in the history of the failing yet oh so grand (and hopefully getting better) experement known as nintendo. has the bad habit of sniggering at players when they dont hit the ever speed increasing ducks.
im gonna freaking KILL THAT DOG!!
автор: Link the Wolf 6 мая 2005
Trending Now
Can you define these popular missing words?


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on March 7, 2013 - 10:18 PM
, updated March 8, 2013 at 10:01 AM
NEWARK, N.J. – Jhonas Enroth was just more than a minute away from his first victory in 16 months. Suddenly, he couldn't move his right leg and had to be helped to the Buffalo Sabres' dressing room as New Jersey's fans celebrated a tying goal.
It turned out the only thing injured was Enroth's pride.
The Buffalo backup goaltender cramped up near the end of his first start in more than a month, ending a night filled with highlight-reel, confidence-boosting saves. He was in the back when the Devils completed a stunning rally by beating Ryan Miller and the Sabres in a shootout, 3-2.
"I was so close," said Enroth, who hasn't won in 15 appearances dating to November 2011. "I'm very disappointed. I don't know what to say. I've just got to come back here and try to get better, I guess."
Enroth's night – and the Sabres' 2-1 lead – came to an end with 1:06 to play in regulation. Enroth kicked David Clarkson's shot from the point directly to a driving Patrik Elias. The goalie dived across the crease to try to get in the way, but the puck went in as the fans in Prudential Center roared.
Enroth stayed on the ice, but it wasn't in disappointment over allowing the tying goal. He needed to be helped to the dressing room by athletic trainer Tim Macre, unable to put any weight on his right leg.
He allowed two goals on 29 shots, but both came in the final 6:30 as the Sabres' 2-0 lead transformed into a 0-1-2 slide.
"Those are the games we've got to close," captain Jason Pominville said. "There's no excuses for it. We've got to find a way to close those games."
Miller stopped four shots in the final minute and overtime. David Clarkson and Elias beat him in the shootout while Thomas Vanek and Pominville failed in their attempts for Buffalo.
The loss and Enroth's early departure overshadowed what had been a memorable night.
The Sabres' power play struck for the second time in as many games as Vanek opened the scoring midway through the second.
Buffalo doubled its lead with 10:04 left in regulation as Brian Flynn earned a prized souvenir.
Andrej Sekera's point shot hit a body in front, and Flynn promptly whacked the deflection toward Johan Hedberg. The goalie got a piece of the shot with his pad but not enough to keep it from going through his legs to start a celebration.
Marcus Foligno and Christian Ehrhoff both went after the puck, then joined the hugs and fist taps as smiles radiated for Flynn's first NHL goal.
"At the time it was awesome," Flynn said, "but it doesn't feel as good now after losing the game that way."
The Devils started to put a damper on Enroth's welcome-back party with 6:30 to play. With Ehrhoff in the box for holding, fellow defenseman Mike Weber got in the way of Adam Henrique's close-range blast. As Weber hit the ice in pain, Henrique picked up the puck and ripped it high into the net.
Enroth was feeling tight as the 17,625 fans partied.
"I was cramping pretty much the whole third period there," said Enroth, who is 0-10-2 in his last 12 decisions, including a loss in his previous start Feb. 5 in Ottawa. "I've got to take a little more care of my body when I'm playing. I haven't been playing in a while, so I probably should have been drinking more water and Gatorade and stuff like that before the game."
Hedberg made 23 saves to end his seven-game winless streak and send the Sabres into Sunday's game in Philadelphia with a three-game slide.
"We would have liked to have a better outcome, but we're doing things a lot better as a team," said Sabres interim coach Ron Rolston, who liked his first look at Enroth. "It was a hard outcome for him, but life's hard. He's got to bounce back. I know he will. I liked what he did. He made some huge saves for us."
email: email@example.com


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World's most expensive phone heading to China at $15 million, bound to raise eyebrows in the Party
0. phoneArena 12 Apr 2013, 09:15 posted on
Custom-ordered by an unnamed Chinese businessman, the iPhone 5 is dipped in 26 karat gold, a real black diamond has replaced the home key, and 600 "regular" diamonds have been engraved in the chassis. The screen protection has been replaced with sapphire glass, which is much tougher than Gorilla Glass, and it took the designer nine weeks to hand-make the unique handset...
This is a discussion for a news. To read the whole news, click here
1. eliasafram7 (Posts: 83; Member since: 18 Mar 2013)
outside rocks but inside sucks
17. Topcat488 (Posts: 1396; Member since: 29 Sep 2012)
Maybe you get a life time of ios updates, and a perpetual chip update, and other internal hardware from Apple... ;)
28. vincelongman (Posts: 4445; Member since: 10 Feb 2013)
Or buy this brushed gold wrap/skin for only $19.95, also available for Galaxy S III and Evo G4. Its not made out of gold obviously, but feels and looks like it is.
2. sheik (Posts: 249; Member since: 12 Sep 2012)
Want it!!
filthy rich
25. bbblader (Posts: 590; Member since: 24 Oct 2011)
...and very stupid
3. amats69 (Posts: 1447; Member since: 12 Nov 2012)
wow!thats a lot of money!
4. zeropants (Posts: 32; Member since: 31 May 2012)
This shows that having money doesn't always reflect having good taste.
5. BillyG (Posts: 305; Member since: 24 Sep 2012)
this sentence usually come from poor people as an automatic defense mechanism
14. zeropants (Posts: 32; Member since: 31 May 2012)
Those types of responses usually come from people who don't have a good point.
In no reference to the phone, anything that large dipped in gold and covered in diamonds is gaudy.
15. lyndon420 (Posts: 4399; Member since: 11 Jul 2012)
This sentence is insinuating that you are rich then? Gonna buy yourself an iPhone are ya? Because it's what rich people do?
23. zeropants (Posts: 32; Member since: 31 May 2012)
I see the "no reference to the phone" part threw you off.
No part of that sentence insinuated me being rich.
34. MobileJunkieJr (Posts: 46; Member since: 15 Mar 2013)
He's replying on BillyG's thread, not yours.
You're going to embarass yourself.
41. BillyG (Posts: 305; Member since: 24 Sep 2012)
see, zeropants is not only poor, he's also stupid...
42. BillyG (Posts: 305; Member since: 24 Sep 2012)
nope, not gonna buy an iPhone. iPhones are for normal people... an iPhone dipped in gold and engraved with diamonds is for rich people.
26. HDShatter (Posts: 1021; Member since: 17 Jan 2013)
$15 million, still a pos.
31. EXkurogane (Posts: 863; Member since: 07 Mar 2013)
That's true. How the rich spend their money is none of your concern, because it is their money, not your money. I wouldnt call someone who spends thousands of dollars on designer goods as wasting money either, it's their right to spend their own money the way they want.
But if i have that kind of money i would have set my sights on a Lamborghini. I wouldnt even hesitate to buy one. But then again, someone who can afford this phone probably already has a dozen of supercars in his garage.
"If i have that much money i would help *** ***", that's something only hypocrites will say. If you have that much money one day, maybe from the lottery, you would definitely think of luxury or enjoyment first. It's human nature in our subconscious minds. Find me a millionaire who drives a budget small car. NONE.
6. GadgetsMcGoo (Posts: 168; Member since: 15 Mar 2013)
Ouch if this iPhone 5 bends like the other iPhone 5. Would be expensive to fix.
7. xperiaDROID (banned) (Posts: 5629; Member since: 08 Mar 2013)
I'm not rich, so I must say DUH!
I mean seriously? $15 million for an iPhone 5? When you're using this phone outside, you'll be the first one to be robbed!
If I'm rich, I won't even think about this phone! I rather get an original iPhone 5 instead! :P
32. moroninc (Posts: 193; Member since: 14 Jul 2012)
"IF" and if you were.. you'd be the first to get robbed even if you have an original iphone 5
35. xperiaDROID (banned) (Posts: 5629; Member since: 08 Mar 2013)
Everyone with smartphone may be robbed, that's why we need to beware of robbers, their eyes are watching your smartphone!
8. spiderpig2894 (Posts: 588; Member since: 10 Jan 2012)
It would look much better without the diamonds at the sides and home button (personal preference). Still won't buy one even if I am a billionaire.
9. eliasafram7 (Posts: 83; Member since: 18 Mar 2013)
look for poor people who are hungry in africa and give them money instead of buying a crap just for look
10. luckysrinu (Posts: 14; Member since: 04 Sep 2012)
Daniel, GSMarena saying 9 months, which is correct?
11. BadAssAbe (Posts: 456; Member since: 22 Apr 2011)
Can I get a custom order?
Samsung Galaxy S4 with Sapphire Glass, water proofed and aluminum casing, please.
12. PhoenixWright (Posts: 102; Member since: 11 Feb 2013)
"the handset is dipped in 26 karat gold"
-The phone must have melted inside since its dipped in gold leaving a gold brick behind.
13. g2a5b0e (Posts: 3724; Member since: 08 Jun 2012)
26 karat gold? So, you're saying the phone is 108.3% gold? 100% gold is 24 karats. Might want to amend the article to reflect that.
18. D_Tech-tive (Posts: 104; Member since: 12 Feb 2012)
It's Igold ...it's concentrated. LOL
27. darkkjedii (Posts: 21359; Member since: 05 Feb 2011)
16. jibraihimi (Posts: 764; Member since: 29 Nov 2011)
15million US$ whoooao........ Many Chinese could start up new phone manufacturing unit in that much money............
19. AndiAllDay (Posts: 14; Member since: 11 Apr 2013)
Is it part 2 of the movie "tower Heist" where the gold is invested in the car****If I want to invest in gold, then I will buy gold to do so, but not to buy phn with gold; **
20. mrvid (Posts: 77; Member since: 02 Oct 2008)
No such thing as 26 carat gold, moron!
24. tedkord (Posts: 11711; Member since: 17 Jun 2009)
There is inside the RDF.
21. wizzardtech (Posts: 59; Member since: 12 Mar 2012)
dumbest and most retarded millionaire i ever heard. She should give the money as xmas bonus for all the underpaid workers in foxconn.
22. nando2do (Posts: 53; Member since: 10 Nov 2011)
i saw this on a picture i think it was shakira or beyonce who had it. i thought it was a case
29. InspectorGadget80 (unregistered)
ugliest phone ever
30. itreday (Posts: 68; Member since: 24 May 2012)
@dd4444 on Instagram does the same thing for a far cheaper price. Except It's not 24 Karat gold but 24ct.
38. InspectorGadget80 (unregistered)
I'll just melt the phone take the golden parts rebuld it too a bar then sell it
33. kurejikame (Posts: 12; Member since: 27 Jun 2012)
The source says the phone was dipped in 24ct gold, and the home button was replaced by a 26ct black diamond. Daniel P. probably accidentally mixed them up.
37. joseph98 (Posts: 167; Member since: 03 Feb 2012)
There is no such thing as 26 Karat gold. "24 carat gold means 99.99% pure gold" and this is as high as it goes it terms of karat.
39. Xtasy (Posts: 284; Member since: 13 Jan 2013)
I will take the phone for what it's worth...but would never buy an iphone otherwise
40. psigate (Posts: 13; Member since: 24 Sep 2012)
26 Karat gold? i thought 24K is already pure gold
43. g2a5b0e (Posts: 3724; Member since: 08 Jun 2012)
Now, it starts to make sense. The black diamond replacing the home button is 26 carats. How PhoneArena turned that into the phone being dipped in "26 karat" gold, I'll never figure out.


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ISHKQ IN PARIS first poster: Preity Zinta is in love again!
4 years ago
PZ's comeback film seems to bring back the bubbly babe we knew After a visual representation of three mood shots of Paris taken at the Eiffel Tower, a bar lounge and a library café, Preity Zinta tweeted the poster of her maiden production Ishkq In Paris.
Read Article ▶
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Here's how Ranbir Kapoor celebrated his birthday on the sets of Jagga Jasoos - view pics!
Salman Khan SAVES Karan Johar from the wrath of Raj Thackeray's MNS - here's how!
We have deets of Varun Dhawan's hush-hush date night - watch video!
Akshay Kumar wanted to marry this woman much before he met Twinkle Khanna!
3 times Deepika Padukone's RIVALS bonded with Ranveer Singh!
Kapil Sharma invites India's Paralympic champs on his show!
Hey Suriya, Ranveer Singh has something to say to you - watch video!
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Pakistani celebs controversies!
Fawad and Mahira should be replaced from Ae Dil Hai Mushkil and Raees, demands MNS
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Oh No! Fawad Khan's next with Salman Khan SHELVED?
Ranbir Kapoor REACTS to MNS' threat to Ae Dil Hai Mushkil and Fawad Khan-watch video
Pakistani singer Rahat Fateh Ali Khan feels the pinch now, to get replaced by an Indian singer!
Not just Fawad Khan's Ae Dil Hai Mushkil, Atif Aslam's Gurgaon concert also affected by the ban
After MNS' threat to Karan Johar, VHP now wants Shafqat Amanat Ali's concert in Bengaluru to be cancelled
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Glossary of Cancer Terms
Waldenström's macroglobulinemia An indolent (slow-growing) type of non-Hodgkin's lymphoma marked by abnormal levels of IgM antibodies in the blood and an enlarged liver, spleen or lymph nodes. Also called lymphoplasmacytic lymphoma.
warfarin A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).
wart A raised growth on the surface of the skin or other organ.
watchful waiting Closely monitoring a patient's condition but withholding treatment until symptoms appear or change. Also called observation.
watercress (Nasturtium officinale) Parts of the flowering plant have been used in some cultures to treat certain medical problems. It may have anticancer effects. Also called Indian cress.
WBC White blood cell Refers to a blood cell that does not contain hemoglobin. White blood cells include lymphocytes, neutrophils, eosinophils, macrophages and mast cells. These cells are made by bone marrow and help the body fight infection and other diseases. Also called white blood cell.
wedge resection A surgical procedure to remove a triangle-shaped slice of tissue. It may be used to remove a tumor and a small amount of normal tissue around it.
well-differentiated lymphocytic lymphoma An indolent (slow-growing) type of B-cell non-Hodgkin's lymphoma marked by swollen lymph nodes that usually occurs in people older than 50 years. It is very similar to a form of leukemia called chronic lymphocytic leukemia (CLL). Also called small lymphocytic lymphoma.
Wermer's syndrome A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors (usually benign) cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems and severe ulcers. In some cases, tumors inside the pancreas can become cancerous. Also called multiple endocrine adenomatosis, multiple endocrine neoplasia type 1 syndrome and MEN1 syndrome.
Western medicine A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called conventional medicine, mainstream medicine, orthodox medicine, biomedicine and allopathic medicine.
Whipple procedure A type of surgery used to treat pancreatic cancer. The head of the pancreas, the duodenum, a portion of the stomach and other nearby tissues are removed.
white blood cell (WBC) Refers to a blood cell that does not contain hemoglobin. White blood cells include lymphocytes, neutrophils, eosinophils, macrophages and mast cells. These cells are made by bone marrow and help the body fight infection and other diseases. Also called WBC.
Whitmore-Jewett staging system A staging system for prostate cancer that uses ABCD. "A" and "B" refer to cancer that is confined to the prostate. "C" refers to cancer that has grown out of the prostate but has not spread to lymph nodes or other places in the body. "D" refers to cancer that has spread to lymph nodes or to other places in the body. Also called the ABCD rating or the Jewett staging system.
whole cell vaccine Vaccine made from whole tumor cells that have been changed in the laboratory.
whooping cough A serious bacterial infection of the lungs and breathing tubes that spreads easily. Whooping cough begins like a cold, but develops into severe coughing and gasping for air. Long spells of coughing may cause vomiting, and broken blood vessels in the eyes and on the skin. Also called pertussis.
wide local excision Surgery to cut out the cancer and some healthy tissue around it.
wild clover (Trifolium pratense) A plant with flowers that has been used in some cultures to treat certain medical problems. It is being studied in the relief of menopausal symptoms and may have anticancer effects. Also called red clover, purple clover and Trifolium pratense.
will A legal document in which a person states what is to be done with his or her property after death, who is to carry out the terms of the will, and who is to care for any minor children.
Wilms' tumor A disease in which malignant (cancer) cells are found in the kidney, and may spread to the lungs, liver or nearby lymph nodes. Wilms' tumor usually occurs in children younger than 5 years old.
windpipe The airway that leads from the larynx (voice box) to the bronchi (large airways that lead to the lungs). Also called trachea.
wisdom tooth The last tooth to come in at the back of each side of the upper and lower jaws. Wisdom teeth usually come in between 17 and 23 years of age, but not everyone has them. Also called third molar.
Wobe-Mugos E A mixture made from an extract of the calf thymus gland and enzymes (proteins that speed up chemical reactions in the body) from the papaya plant, the pancreas of cows, and the pancreas of pigs. It has been used in Europe as a treatment for a variety of cancers and for herpes virus infections.
womb The small, hollow, pear-shaped organ in a woman's pelvis. This is the organ in which a baby grows. Also called the uterus.
wound A break in the skin or other body tissues caused by injury or surgical incision (cut).
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Top Definition
adj. A non-word, created to express a large number of something.
Combines the words 'big' and 'million'.
Combines the words 'big' and 'million'.
Of course I know where it is, Carl, I have driven there a bigillion times.
door Nagem 30 augustus 2004
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Can you define these popular missing words?
A "big" million. A really large number.
Our debug lab is very noisy because it has a bigillion fans running in the test machines.
door B. Bell 28 september 2011
the amount of cute that goes into a Disco Zombie Girl
Amy is cute times a bigillion.
door xxxxxxxxxxx 2 augustus 2006


text:
on November 11, 2012 - 11:41 PM
It was too much money spread over too long a time for state officials not to break open the piggy bank.
It was supposed to be a 50-year deal to help Niagara Falls and other communities impacted by the hydroelectric dam on the Niagara River.
Instead, it's becoming a future revenue source that state officials have found they can spend today.
And they're using it as a Band-Aid to financial problems in Niagara Falls the state had a hand in creating.
Talk about a typical Albany solution.
Gov. Andrew Cuomo last week touted a deal to advance payments from the New York Power Authority to Niagara Falls as the state "stepping up" to provide fiscal stability in the Falls.
But it's the state's actions in its dispute with the Seneca Nation that helped create the mess that left the Falls scrambling when money from the Seneca Niagara Casino dried up.
The state blames the Senecas for refusing to pay the slots revenue. The Senecas claim their exclusive rights to run casinos were violated.
Niagara Falls, meanwhile, is stuck in the middle, with little say over the matter and projects it planned to pay for with casino cash piling up.
Backed into a financial corner, Mayor Paul Dyster and the City Council have been calling for help. That's where the New York Power Authority comes in.
The Falls – along with other communities – negotiated a 50-year settlement in 2007 that allowed the state agency to relicense its Niagara River power project. The city gets low-cost power, money for greenway improvements and annual payments of $850,000.
Under the deal approved Friday, the Power Authority will advance those future payments to the city in a lump sum of $13.45 million. The one-time revenue is supposed to help the city until arbitration puts an end to the dispute between the Senecas and the state.
The hope is casino revenue will flow again, the Falls can return the money and resume its annual payments. Before the lump sum, the city was owed 44 more payments totaling $37.4 million.
City officials believe the long-term payments might be worth more once they're out of the current financial bind.
Here's why: The Power Authority calculates what the future payments are worth today based on a 2007 formula. But interest rates have since changed.
There's a clue they might be right. State parks officials had also sought an advance for projects at Niagara Falls State Park. But the state agency found that borrowing money was a better deal today than taking the advance.
You might wonder why the Falls uses casino revenue in its budget. Some pays for the cost of having a casino. But a large chunk of that money is used to pay debt on a new public safety building. Who pressured the city into replacing its aging courthouse and police station or risk losing millions of dollars in budget aid?
The state.
email: firstname.lastname@example.com


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Wednesday, June 26, 2013
Registration has started for the Summerville YMCA's Youth Triathlon Training – geared towards local youth interested in getting ready to swim, bike and run at the Y's annual Youth Triathlon.
The training program will begin July 9 and will run through Aug. 1. The 2013 Youth Triathlon is scheduled for Aug. 17 at The Ponds Farmhouse.
The training program will provide children ages 7-14 the opportunity to practice the three legs of the triathlon and the opportunity to be coached by seasoned triathletes and YMCA staff. Program participants will meet Tuesday and Thursday evenings from 6-7:30 p.m. Fees for the training are $75 for Y members and $110 for potential members. The program fee includes the registration fee for the triathlon.
The YMCA Youth Triathlon kicks off at 7:30 a.m. with the swimming portion. The older age group (ages 11-14) swims eight lengths of the pool at The Ponds Farmhouse and the younger age group (ages 7-10) swims four lengths of the pool. The participants enter the water one at a time, at intervals of 10-15 seconds.
After finishing the swimming portion, participants exit the pool to the transition area. There they don their bike helmets, shirts, and shoes and begin the biking stage of the event. The older participants complete two 2.5-mile laps throughout The Ponds community and the younger participants complete one 2.5-mile lap.
The third and final leg of the event is the run. Older athletes run 1.0 mile on a trail throughout The Ponds nature conservancy and the younger athletes run a half-mile. All runners will finish at The Ponds Farmhouse.
The triathlon began with a brainstorm from Dr. Hal Hatchett who is a resident of The Ponds, an avid triathlete and Summerville podiatrist. In 2009, he approached Y officials to see if they would be interested in coordinating the event. Last year was the fourth year for the Youth Triathlon and approximately 230 children participated in the event.
To register online or download a registration form visit SummervilleYMCA.org/YouthTriathlon. The fee is $20 prior to July 27 and $30 after July 31. There is no race day registration and the event is limited to 300 participants.
© 2016 The Journal Scene an Evening Post Industries company. All Rights Reserved.
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Modal En-chant-ment
By JörgB on Jun 26, 2009
Last night we went to listen to Early Music performed by the Ensemble Cantus Modalis at St. Cosmae. They sang music from the 15th and 16th centuries, often alternatim with the great 1674 Huss/Schnitger organ of St Cosmae.
This concert was a great experience. After a while the slowish tempo of the music takes hold of the listener and makes this a meditating experience. The singers are specially trained to perform music of that time and their technique produces a special tone, that is very different from classical or most modern music. I had never really appreciated this special color when listening to recordings, but in this live performance it was apparent right away. The organ fit very well with the choir sound in the quieter, woodwind registrations, though at times, when adding more registers, it became a bit too loud for my taste.
Of course we took a recording of the choir (the complete musical works of Christiaan van der Ameyden) back home.


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As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
Too many new drug compounds fail in late-stage clinical trials due to inefficacy and safety concerns. With often-cited costs of $800 million to bring a new drug to market, a compelling need exists for improved early-stage screening. Insufficient knowledge of potential human toxicity can turn a promising lead candidate into a devastating loss. Emerging technologies that will change the existing paradigm were highlighted at Mondial Research Group's recent conference on "Predictive Human Toxicity and ADME/Tox Studies (Absorption, Distribution, Metabolism, Elimination, and Toxicity)".
"Every drug that fails in a clinical trial or after it reaches the market due to some adverse effect was 'bad' from the day it was first drawn by the chemist," stated Robert Fraczkiewicz, Ph.D., team leader, ADMET cheminformatics at Simulations Plus. "Although state-of-the-art in silico structure-property prediction tools are not yet able to predict every possible toxicity for new molecular structures, they are able to predict many with good enough accuracy to eliminate poor molecules before synthesis."
Just like humans with their individual characteristics such as age, weight, and height, calculated molecular descriptors (e.g., number of atoms, molecular weight, shape, and other parameters) quantitatively describe molecular structures.
Simulations Plus' ADMET Predictor software mathematically correlates measured chemical-compound properties with their molecular descriptors to build predictive models. Currently, the application offers 133 predictive models and can process approximately 200,000 compounds per hour on a personal computer, Dr. Fraczkiewicz explained.
In silico usage is only widespread for a few select properties that have had long-time usage as primary indicators of potential new molecule druggability such as logP predictions (octanol-water partition coefficient), Dr. Fraczkiewicz noted. LogP predictions measure molecular hydrophobicity, which affects drug absorption, bioavailability, hydrophobic drug-receptor interactions, and may affect toxicity.
Current ionization, solubility, and permeability predictors range from simple equations to sophisticated, and quite accurate, artificial-neural-network ensembles such as the models implemented in ADMET Predictor, which are based on a combination of molecular and atomic quantum-level descriptors.
"Today, many in silico predictions have the same margin of error as their in vitro counterparts. We will not likely ever eliminate the need for in vitro or in vivo experiments for all molecules, but better in silico models can allow focusing the resources for these experiments where they are truly needed," concluded Dr. Fraczkiewicz.
Assays using primary cells, which represent in vivo physiology better than immortalized cell lines, can provide more accurate predictions of in vivo compound activity. "You can get false negatives and false positives from cell lines that are not primary cells," advised Nicola Hewitt, Ph.D., scientific consultant, Medicyte.
Medicyte's upcyte® technology addresses the major drawback in using primary cells for high-throughput-screening campaigns—that is, the difficulty in obtaining the needed number of cells.
"With our proprietary technology we identified genes that can induce and maintain proliferation of primary cells, circumventing the natural barrier points. Using a lentiviral gene-transfer system, we achieved effective transfer of these genes into human primary cells. These genetically engineered upregulated primary cells, termed upcytes, can be passaged for at least an additional 20 to 40 doublings. Up to 1,800 vials, containing 6 x 106 cells each, can be obtained from one vial of primary cells," explained Dr. Hewitt.
With the ease-of-handling of cell lines, upcyte cells display the stable, normally differentiated phenotypes of primary cells. Cells from multiple donors provide experimental breadth early in the testing process.
Quality control consists of cell characterization at predetermined stages of proliferation. For example, upcyte hepatocytes are tested for expression of adult cell markers, the Dkk3/REIC gene (Reduced Expression in Immortalized Cells), glycogen storage, albumin and urea secretion, and inducible enzyme activity.
CYP3A4, one of the most important enzymes involved in the in vivo metabolism of xenobiotics, is a major target for many drug compounds. Inhibition of CYP3A4 by 10 mN ketoconazole decreases aflatoxin B1 toxicity similarly in primary cells and upcyte hepatocytes from multiple donors. Additional screening tests using compounds with a range of toxicity correlated well with in vivo hepatotoxicity.
Thought to be responsible for 30 to 40% of previously undetected clinical tolerance problems resulting in cardiac and drug-induced liver injury (DILI), mitochondrial liability identification has become a prerequisite to IND submission for antivirals and is recommended by the FDA and the EMA for preclinical DILI anticipation.
"To identify mitochondrial liabilities with existing tests, you need four different screens using different models and different technologies with different sensitivities, which makes interpretation difficult and untranslatable site-to-site," says Nathalie Compagnone, CEO, ICDD-sas.
"In addition, many existing tests use isolated mitochondria that respond to the experimental medium more than if they had the proper cellular environment. ICDD-sas carries out human in vitro systems using either biochemical or high-content analysis on live cells, and looks at the functional and dynamic response of mitochondrial to establish the toxicity liabilities of a drug."
Mitosafe® is a series of mechanistic-based, preclinical-screening technologies that quantify bioenergetic balance, redox (reduction-oxidation), and mitochondrial DNA depletion statuses, the main biological aspects that a drug affects in the mitochondria. This balanced assay measures both anatomic and functional outcomes, identifying mitochondrial liabilities.
Inventors of the concept of mitochondrial behavior, ICDD-sas evaluates 48 parameters on living primary cells to quantify and qualify mitochondrial behavior. Adverse drug reactions can be forecast with 83% predictivity and >90% sensitivity and specificity.
The Mitostream technology, an experimental-system-biology predictive tool validated by the Drug Safety Executive Council and numerous pharmaceutical companies, is applied typically at the lead candidate level. Mitostream technology, which measures the cell adaptability in response to a drug, has proven effective in predicting clinical tolerance and is used for managing clinical trials.
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Developers of DTC Genetic Testing Are...
LC-MS Gains Favor Due To the...
As Immunotherapy Revolutionizes the Cancer Treatment...
Quadruple Helices Appear To Have Role...
A term originally coined by Conrad Hal Waddington in the 1940s to describe the causal relationship between genotypes and phenotypes, epigenetics has witnessed profound transformations as a concept.
The increasing appreciation of the roles that epigenetic changes play in a growing number of medical conditions opened the attractive possibility to therapeutically modulate them, and the approval of the first four epigenetic compounds set the stage for a new era that promises to reshape the therapeutic arena.
"We are pursuing drug discovery in a variety of areas relevant to chromatin structure and function, and this is the key feature that allowed us to establish our industry-leading programs in these areas," says Jim Audia, Ph.D., CSO at Constellation Pharmaceuticals.
The most advanced of the epigenetic drug discovery efforts at Constellation, the BET (bromodomain and extra-terminal) program, focuses on small molecule inhibitors of the BET family proteins. In mammals, the BET family includes the ubiquitously expressed Brd2, Brd3, and Brd4, and the testis-specific isoform BRDT, which function to facilitate gene activation.
Each of these proteins has two N-terminal bromodomains, which harbor a deep, hydrophobic pocket that recognizes specific acetylated lysine residues on histone tails. "Their very well-formed pocket allows us to use structure-based drug design to find binding sites for small molecule inhibitors," says Dr. Audia.
While pursuing this work, other researchers discovered that BET proteins selectively regulate the NF-κB pathway in inflammation, prompting Constellation to pursue this mechanism in oncology due to the importance of NF-κB-dependent transcriptional signaling in many malignant tumors.
One of the surprising findings was that BET proteins, particularly Brd2 and Brd4, localize to the transcriptional start sites of the myc oncoprotein, downregulating its expression in a variety of cellular contexts. The possibility to directly displace them by small molecule inhibitors promises opportunities to rapidly and potently suppress myc transcription in an oncology setting.
"We found a relatively broad subset of hematological malignancies that appear to be very sensitive to bromodomain inhibitors, and we are now optimizing our initial prototypic targets to ultimately make them become clinically relevant molecules," explains Dr. Audia. This work, in addition, promises to elucidate in more detail the biology of the proteins involved in chromatin remodeling.
"We are learning how context-dependent everything is, how subtly different the effects of some of these targets may be depending on the cell type and on the state of the cell. One of our goals, that we think is both possible and advantageous, and perhaps even necessary, is to understand the factors that control this chromatin-based signaling," reveals Dr. Audia.
Constellation recently reported its collaboration with the Leukemia & Lymphoma Foundation to support preclinical and Phase I programs that explore the therapeutic potential of BET bromodomain inhibitors in hematological malignancies.
"In addition, we have an exclusive collaboration with Genentech, a broad effort that is being driven by the belief that a number of targets across various methyltransferases, demethylases, and bromodomain readers offer the potential for significant therapeutic applications," says Keith Dionne, Ph.D., president and CEO at Constellation.
The collaboration is not restricted to therapeutic targets in malignant tumors. This reflects the vast body of experimental findings that underscore the key roles that epigenetic modifications play in medical conditions outside the sphere of oncology such as inflammatory, neurodegenerative, and cardiovascular diseases.
"Rapid progress in these areas is driven by a partnership between chromatin biology and chemistry, which work together to understand the specificity of the interaction from the chemistry side, and the therapeutic impact from the biology side," explains Dr. Dionne.
"GlaxoSmithKline plans to take EZH2 inhibitors into the clinic in cancer," says Peter J. Tummino, Ph.D., head of biology, cancer epigenetics discovery performance unit at GlaxoSmithKline (GSK). EZH2, the catalytic component of the polycomb repressive complex 2 (PRC2), represses gene transcription by methylating lysine 27 residues on the histone H3 tails. EZH2 overexpression has been reported in several types of solid tumors while, in contrast, mainly EZH2 point mutations were described in lymphomas.
"We found that these heterozygous mutations are biochemically neomorphic, an aspect that was not obvious when the mutations were discovered," explains Dr. Tummino.
The presence of these gain-of-function EZH2 mutations pointed toward a desire to therapeutically inhibit the activity of the protein. Previously, scientists at GSK have developed several new reagents that helped conduct two EZH2 high-throughput screens. "We have been able to develop potent and selective small molecule EZH2 inhibitors that inhibit histone H3 lysine 27 trimethylation and possess potent antiproliferative activity specifically in cells with EZH2 activating mutations," says Dr. Tummino.
Most recently, scientists at GSK described GSK126, a small molecule EZH2 inhibitor that can reactivate silenced PRC2 target genes. GSK126 inhibited the proliferation of diffuse large B-cell lymphoma cell lines harboring a heterozygous Y641 gain-of-function mutation, which is the most frequently encountered EZH2 mutation in this group of malignancies, and inhibited the growth of EZH2 mutant diffuse large B-cell lymphoma mouse xenografts.
"Our approach differs from the one used by many other epigenetic companies, in that we specifically target individual genes to upregulate," says Arthur Krieg, M.D., president and CEO at RaNA Therapeutics. Investigators at RaNA achieve this specificity by targeting individual noncoding RNA molecules that bind PRC2 to repress the expression of individual genes.
"Oligonucleotide therapeutics are particularly well suited for this, because we can take advantage of the Watson-Crick base-pairing to specifically target individual genes, and with the knowledge coming out on noncoding RNAs, we can now accomplish this in a highly selective fashion," notes Dr. Krieg.
One of the target genes that Dr. Krieg and colleagues used to illustrate this proof of concept is erythropoietin. "By using an oligonucleotide to target a noncoding RNA, we were able to prevent PRC2 recruitment to the erythropoietin locus, derepress gene expression, and upregulate erythropoietin expression in vitro and in vivo," explains Dr. Krieg. Investigators at RaNA are planning to use this approach as they proceed toward clinical development with several therapeutic targets.
"We live in the next frontier in genetics and genomics, and one of the big advances has been the understanding that epigenetics is involved, in an ongoing basis, in regulating the expression of most genes in the genome in a highly selective and tissue-specific manner," explains Dr. Krieg.
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text: Scenes from fall 2012 in the Northeast Kingdom Posted on October 17, 2012 by BethanyMDunbar PausePlayPlayPrev|Next This is a drawing of the Renaissance Block, planned for Newport's Main Street. The Spates block will be torn down to make way for the Renaissance Block in Newport. Photo by Joseph Gresser Anthony Lazarra of Morgan had a great year for pumpkins and gourds in his garden. Shaquille Urie of Lake Region heads the soccer ball in a game against People's Academy. Photo by Richard Creaser Carmen Anderson of Westmore grew this startling tomato. This photo was taken in 1941. The hunter is Bertha Wood Chamberlin, who was 24 years old at the time the photo was taken. She shot a bobcat and a deer in one day. Bob Davis of Craftsbury makes a call at the Malcolm R. Davis Funeral Home. Mr Davis and his wife, Louise, are selling the funeral home to Curtis-Britch-Converse Rushford of Newport. Photo by Bethany M. Dunbar Markus Vogt of the Northeast Kingdom Learning Services serves up some chili during Newport's annual chili fest, which benefits Vermont's North Country Chamber of Commerce. Photo by Richard Creaser Hostas get buried by falling autumn leaves. Photo by Joseph Gresser Foliage is at peak around Orleans County this week as Holsteins at the Urie farm on the corner of Mud Island Road and the Shadow Lake Road in Glover show off their best sides. Photo by Bethany M. Dunbar


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The only thing that tempered my excitement for U2 bringing their 360 Tour to my hometown was my fear of what the weather might bring. Getting soaked during the concert was not my idea of fun, but it did not dampen most people's enthusiasm during the show. However, in the spectrum of unpredictable Minnesota weather, heavy rain is much preferable to hail, high-winds and tornadoes (lightning seemed to be a non-issue, mercifully). At least with an outdoor concert scheduled in July in Minnesota, a blizzard does not enter into the forecast.
I think the only way I can adequately review my Minneapolis U2 weekend is to break it down into three parts: the Friday night Interference.com fan club get-together, the concert itself and the overall TCF Bank Stadium experience.
Interferencers (Blue Craicers, whatever) are rabid fans. We have been chomping at the bit for almost two years to have our fan meet-up in Minneapolis. It is always exciting to meet people that you have connected with online, but there often is a little apprehension, too. The "What if they don't like me? What if I don't like them? What if no one shows up?" thoughts run through my head. As has been my experience for this tour, those thoughts are useless. The other Minnesota fans are cool, nice people, and as a huge bonus, many fans from around the country (and a few from around the world) came to Minneapolis for the meet-up.
The Leaning Tower of Pizza on campus could not have been better hosts. Great, friendly servers keep us in drinks and food. It also helps to have a gathering in a university bar because no one blinks twice when there are spontaneous sing-a-longs to the U2 blaring from the jukebox. It was wonderful to see familiar faces again and a joy to meet so many new people, whether they were new to Interference or new to me in a non-internet setting.
Our plans for the concert as fans spanned a broad range; Some were going to get in the General Admission (GA) line almost immediately after the Friday night meeting, many of us were going to get in the GA line sometime during the afternoon, a few were lucky to have gotten Red Zone tickets, and a few others were headed for seats.
Walking in to the stadium, it was hard not to just stare at U2's "Claw" stage even if I had seen it 10 times previously. It filled the field more than I had seen at any other show. After my initial awe, my eyes kept looking up to the skies, even though I had made peace with the possibility of rain. The hiking jacket and multiple Ziploc bags I had helped to mollify that fear.
There is far too much time between when the gates are opened and when U2 finally takes the stage, but it's nice to use that time to wait for your other friends to arrive and to meet those strangers standing near you. As has been my experience for all of the shows I have been to this summer, the people around us ranged from U2 virgins to U2 veterans. It's great to meet everyone, and it reminds me why I like to attend so many shows.
U2 took the stage and played four songs from Achtung Baby. Mysterious Ways barely had finished before the rain began. Edge had some guitar issues during Until The End Of The World, presumably from the wetness. The band and crew obviously knew that it would rain, so while adjustments were made on stage, the U2 continued seamlessly.
I was glad that after Get On Your Boots, Bono acknowledged that Minneapolis at one point was intended to be the final stop to the 360 Tour. This would have been fantastic, but I understand that financial and other considerations led to the final show being in Moncton, New Brunswick, Canada. Final shows often are epic and slightly longer than a normal show. I am ecstatic that I will get to attend that concert as well.
Even without being the final tour stop, it is obvious that the guys hold Minneapolis in high regard. The Vertigo Tour show at Target Center was one of the few tour stops that was honored with a rare second performance of Vertigo as the final encore. I was wondering how they might show their love for my city this time and was glad when Bono combined this affection with a special recognition of our state's large immigrant population from the Horn of Africa. (Minnesota is home to the largest population of Somalis outside of Somalia, as well as many Ethiopians and Eritreans.) Toronto performer and Somali native, K'naan joined the band on stage for wonderful performance of Ben E. King's Stand By Me.
As the rain fell harder, the band played on. I had heard during the 360 Tour shows last fall in Europe that the band, especially Bono and Adam, like to play in the rain and get even more enthusiastic. I didn't necessarily believe that until Saturday night. Bono was having fun despite an occasional glitch from his drenched microphone. And Adam, much to the delight of some fans, finally stripped off his wet shirt. The bare-chested 51-year-old showed off his ripped chest and stomach as he smiled and marched around with his bass guitar.
Sunday Bloody Sunday by Tim Newell (in the pouring rain)
^video link
Snippets of songs about rain were peppered throughout the balance of U2's performance; The highlight being a crooning of Purple Rain by Bono surrounding Leonard Cohen's Hallelujah which led into an amazing Where The Streets Have No Name.
During his introduction of the band, Bono alluded to the type of force of nature he heard from each band member during the previous show in New Jersey. Concluding the introductions with himself, Bono said, "Then I heard the voice of God. He said, 'If you think you're having fun now, wait 'til you get to Minneapolis.'" That was funny on many levels. Bono is well-aware of his detractors who dislike his seemingly messianic traits, but he doesn't care. And also, he is so charming and silver-tongued that I cannot help but half-smile and half-smirk as he so blatantly plays to his current crowd. Bono's personality certainly is a large part of why the band has had such longevity and appeal. He, Edge, Adam and Larry drank in the cheers and applause before leaving the stage after the final song, Moment Of Surrender.
I am pleased that I got to experience a U2 "wet" performance at least once in my fan history. I wish it had been somewhere other than my home city, but there is no doubt that the soaked TCF Bank Stadium crowd loved the show.
The lines into the stadium were handled well; the lines for the buses after the show looked very long and slightly confusing. Overall, I think too many GA tickets were sold. The field was very crowded and finding your way through it was difficult. I am glad there was a plan in place in case of severe weather, but it was hard to believe that there would have been anything other than chaos on the field had there been an emergency. Since this was the inaugural concert at TCF Bank Stadium, some forgiveness can be offered for a little poor planning. Hopefully, for future shows, the stadium management will realize that they need access points to the field from both ends, that some portable toilets are needed on the field itself rather than requiring a long trek to the outside of the stadium and that fewer GA tickets should be sold. These are not minor complaints. The extreme crowding distracted from the show, but given how great U2's performance was, ultimately I can overlook the flaws.
23 July 2011, TCF Bank Stadium
University of Minnesota, Minneapolis
1. Even Better Than The Real Thing
2. The Fly
3. Mysterious Ways
4. Until The End Of The World
5. I Will Follow
6. Get On Your Boots
7. I Still Haven't Found What I'm Looking For
8. Stand By Me (with Somali native K'naan)
9. Stuck In A Moment (And You Can't Get Out Of It)
10. Beautiful Day
11. Elevation
12. Pride (In The Name Of Love)
13. Miss Sarajevo
14. Zooropa
15. City Of Blinding Lights
16. Vertigo
17. Crazy Tonight Remix
18. Sunday Bloody Sunday
19. Scarlet
20. Walk On
21. One
22. Where The Streets Have No Name (Hallelujah intro)
23. Hold Me, Thrill Me, Kiss Me, Kill Me
24. With Or Without You
25. Moment Of Surrender
Review and Photos by kramwest1.
Special thanks to Tim Newell for his valiant video efforts.


text:
The "bible" of public works inspection for over 50 years, the Public Works Inspectors' Manual has become the standard reference for professionals across the nation responsible for inspecting all types of public works construction.
It clearly spells out, in-step-by-step detail, testing procedures and inspection guidelines for virtually every type of work and material - from asphalt and aggregates, to pipe and prestressed concrete. More importantly, this richly illustrated Manual shows you: