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Friday, May 10, 2013
East Cooper Meals on wheels hosted their annual gala and auction last Wednesday evening at the Omar Shrine Temple.
Each year guests gather for this black-tie optional affair to enjoy live and silent auctions, music and signature small plates from more than a dozen local chefs. Guests feasted on culinary delights ranging from traditional southern favorites to international dishes from the Orient and Europe while bid on items donated by over 100 businesses in our community. The evening concluded with a fast-paced live auction featuring all-inclusive getaways, one-of-a-kind excursions and unique packages for every lifestyle.
Chefs came from BACCO, Charleston's Cafe, Falyn's on Forty-one, Gullah Cuisine, Harbor Breeze, Iacofano's, Just Eat This, Kaminksky's, Langdon's Restaurant & Wine Bar | Opal, Lowcountry Eats, Miss Linda's Fine Foods, Outback Steakhouse, Salt Works Catering Company and Wando High School Culinary Arts.
Last year ECMOW delivered 137,481 meals using more than 300 volunteers. Visit www.ecmow.org to learn about donation opportunities and volunteers opportunities.
© 2016 Moultrie News an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


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Tour guide in Bruxelles
Solvay Library Brussels
The Solvay Library is an old and famous venue in Brussels. Many diners, receptions and conferences... Read more
Brussels Town Hall
Brussels' Town Hall is located on the « Grand Place » and is one of the major masterpieces of 15th... Read more
Botanique Brussels
The « Botanique » was opened in 1984 in Brussels. It is the French Community Cultural Centre. It... Read more
Magritte Museum Brussels
The Magritte Museum is located on the Place Royale. It has got the most complete collection of work... Read more
Musical Instrument Museum Brussels
The Musical Instrument Museum in Brussels has been created in 1877. It is one of the greatest in the... Read more
Natural Science Museum Brussels
The Belgian Natural Science Museum presents numerous different species and their evolution through... Read more
BOZAR Brussels
The Centre for Fine Arts is a multidisciplinary museum dedicated to art and culture in Brussels.... Read more
Tintin Walk Brussels
Georges Prosper Remi, better known under the name of Hergé, was born in Brussels. He is the famous... Read more
The Planetarium of the Royal Observatory of Belgium
It is one of the largest planetariums in Europe offering the discovery of the sky.... Read more
Art Nouveau Walk Brussels
Brussels is famous for its Art Nouveau Heritage. This movement originates from Brussels with the... Read more
The MannekenPis Brussels
... Read more
Belgian Chocolate Village
This is one of the largest spaces dedicated to chocolate in Europe. The Belgian Chocolate Village is... Read more

subset: commoncrawl


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'Superblack' | Leather Belt by HUGO
Style No. 50227843
Free Shipping
This belt by HUGO is crafted in Italy from 100% smooth cow leather. Discreet elements like an engraved logo detail at the squared end and tonal topstitch give this style its elegant look.
- Smooth cow leather
- Polished tonal zinc rectangular buckle
- Engraved logo detail at end
- Squared belt end
- Width: 3cm (1.18 in)
- Made in Italy
- HUGO BOSS suggests ordering belts one size up from your actual pant size for the best fit.


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COLUMBIANA Rick Burt started his last day of work like any other day on Monday, waking early and going to the city's street garage at 7 a.m.
Burt has spent the last 42-1/2 years working for the city, most recently as street department foreman. His first job was with the park and cemetery department. He was only 16 years old and still in high school.
Monday, he did what he always did this time of the year. He spent the morning supervising the four full-time crew members with plowing and salting of the roads and fixing the department's equipment.
"This is all I know," Burt said during a brief break from his work. Moments later he would be back with his crew getting salt ready for another expected snowfall.
He had hoped to continue working until he had 44 years with the city, but changes to the Ohio Public Employment Retirement System (PERS) that take effect on Jan. 7 made him reconsider.
His supervisors, Service Director Jay Groner and City Manager Keith Chamberlin, also decided to retire before the PERS changes kick in and Monday was their last day of work as well.
Fact Box
Party planned
An open house for Rick Burt will be held from 2-4 p.m. Saturday in the pavilion near the duck pond at Firestone Park. All are welcome. The Burts ask that gifts be omitted.
Combined, the men have more than 100 years of service with the city, Groner noted.
He recalls working "side by side" with Burt over the years and being impressed with his level of dedication, specifically his initiative to memorize the city's layout to make things easier for the department.
"He's been a good asset to the city," Groner said.
Burt said he wanted to memorize where all of the water valves and manhole covers were so that if a water break occurred the city wouldn't have to spend as much time trying to figure out which valves to close off.
Although it all remains stored in his mind, he has plotted the valve and manhole locations on a map for other crew members to use.
"Now they have GPS so they found more," he said. "You just try to do the best you can to better the city. I just enjoy my job, everything about it."
Burt will be replaced by water department employee Jesse Wilson. The move has already been approved by Groner and Chamberlin.
The two departments work hand in hand, so the transition shouldn't be too difficult, Burt said.
He doesn't intend to spend retirement not working. He already has plans to work with his brother-in-law, Kevin Dickey, who owns a construction business, and his six grandchildren will also keep him busy, he said.
He lives in the city with his wife, Terri.


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|Borrowing Materials From Other Libraries
Patrons looking for materials should first use the SWAN catalog. SWAN is a shared catalog of 80 academic, public and special libraries that provides borrowers access to an extensive collection of resources. The catalog may be used in the Library, at home or at work. Patrons may also call the Reference Desk in the Adult/Young Adult or Children's Departments to see if Woodridge owns an item.
Once patrons have determined that Woodridge Public Library does not own an item, the quickest way to borrow that material from a public library in our nearby area is to actually go to the owning library. All Woodridge Library cards in good standing are honored at other public libraries. Patrons should call the owning library themselves or ask a library staff member to call for them and make sure the item is actually on the shelf. Most libraries will hold materials several days at their Circulation Desks so that patrons can pick them up when convenient. Materials borrowed directly from other libraries may be returned to Woodridge to be delivered back to the owning library.
If patrons have time to wait, Woodridge Library staff will bring items in from other libraries for patrons. Woodridge Public Library is part of an area-wide system (Reaching Across Illinois Library System) as well as part of a state-wide library network (ILLINET). All members of these networks and systems are committed to sharing resources through Interlibrary Loan (ILL). Interlibrary loans are transactions in which library materials are made available from one library to another upon request. An interlibrary loan is defined as a transaction in which the material moves from library to library for a designated user. The Woodridge Public Library adheres to the Reaching Across Illinois Library System (RAILS) Resource Sharing Policy [PDF], the ILLINET Interlibrary Loan Code [PDF] and the Library's Interlibrary Loan Policy [PDF].
To Request and Reserve a SWAN Item
Woodridge Library cardholders with accounts in good standing may directly request and reserve library materials through SWAN. Search the SWAN online catalog for your desired item. When you have identified an item that you wish to request, click on the Request button. You will be prompted to enter your name, Woodridge Library card number and PIN (Personal Identification Number). If you have never entered a PIN before, then go ahead and choose any number. Requesting items from libraries that share our online catalog usually takes 4-5 working days, depending on availability. You will be notified when your item is ready for pick up at the Library. Patrons may select telephone, post card, or email notification. Once the item has arrived at the Library, materials will be held for seven (7) days at the Circulation Desk before they are sent back to the lending library.
Beyond SWAN
If an item is not listed in the SWAN catalog or is not a circulating item in SWAN, you may wish to search WorldCat, an international catalog that includes millions of books, recordings and audiovisual items in libraries of all types. Many of the items can be obtained for Woodridge Public Library cardholders through interlibrary loan. Newly published and non-print materials are often more difficult to borrow depending on the lending policies of the owning libraries.
To Request an Item through WorldCat
Go to the Library's "Online Databases" page. Find and select WorldCat in the Library Catalogs list of databases. Search WorldCat for your item. When you have located an item select the Borrow this item from another library option in the Availability section at the top of the item record. You can also click on the (ILL) icon at the top of the page. Complete the required information fields and include additional comments if you wish. Click Submit. The screen will display a successful resource sharing request confirmation. There is no charge to borrow materials from within Illinois. Items supplied by libraries outside Illinois will incur a $3.00 fee. This fee reflects the actual postage charges the Library incurs in retrieving these materials for you. The Library will try to fill your request using Illinois sources prior to borrowing materials from out of state. Materials coming from libraries outside Illinois take longer to arrive. It is not unusual for materials to take several weeks to be supplied from other states. You will be notified when your item is ready for pick up at the Library or when the request is cancelled.


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People in the Department
The Department
The San Jose Math Department is home to an eclectic array of interesting faculty, lecturers, and teaching associates. The Chair of the department is Bem Cayco. The Associate Chair and Undergraduate Coordinator is Marilyn Blockus. The Graduate Coordinator is Richard Kubelka. The San Jose Math Department is also home of Center for Applied Mathematics, Computation and Statistics (CAMCOS), which is headed by the CAMCOS director, Slobodan Simic.


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The City Council recently recognized the graduates of its first Citizens Academy.
The academy was launched in July to give citizens a chance to learn more about the workings of local government and become more involved in the shaping and development of the community, according to the city. Nineteen residents participated in six sessions conducted over a 12-week period.
Course topics included "City Government 101" which highlighted the city's history, organization and adopted strategic and business plans. Department heads and staff from community services, development services, finance, police, fire and engineering provided overviews of the inner workings, accomplishments and future plans of their respective departments.
Bonnie Turnbull, Chris Beni, Eoin Doherty, Jameson Honeycutt, Josh Hempel, Perry O'Bray, Philip Armstrong, Ruben Zepeda-Raya, Russ Dahler, Ryan Payne, Shawn Kearney and Scott Homolka made up the first class.
The South Lake Tahoe Citizens Academy is a free, six-session interactive course designed to provide residents with an in-depth look into municipal government, as well as, information about the services and programs of the dity of South Lake Tahoe. The next academy will be offered in Spring 2013. For more information, visit www.cityofslt.us/academy.


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Paul Rudd says his friendship with Green Day's Billie Joe Armstrong is the reason that the singer appears in film This Is 40.
Armstrong cameos in the movie as himself while Rudd plays a husband who is constantly fighting with his wife.
The film is written and directed by Judd Apatow who is also behind such hits as Knocked Up and The 40 Year Old Virgin.
The actor was speaking to Newsbeat's Natalie Jamieson.
This Is 40 is released in the UK on 14 February.


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Apple iPhone 4S Review
0. phoneArena 21 Oct 2011, 05:48 posted on
Just like what we saw with the iPhone 3GS in the past, the iPhone 4S is nothing more than an incremental upgrade. Donning a near replica of its predecessor's design, most of the smartphone's juicy new features are found internally as its packs a dual-core processor, upgraded 8-megapixel camera, support for CDMA & GSM connectivity, and its innovative Siri intelligent assistance service...
This is a discussion for a review. To read the whole review, click here
24. shayan (Posts: 159; Member since: 09 Sep 2010)
actually, this is the best iphone so far. at least it reaches the other highend phones in the market. and phonearena just gave it a 8.5!!!
Im still in shock for iphone4 that phonearena gave 9.5 score.
32. Dr.Phil (Posts: 1173; Member since: 14 Feb 2011)
PhoneArena gave it that score because they are Apple lovers. I mean think about it. Look back at how many articles they had for the Apple Iphone 4S vs the new Galaxy Nexus. They had more Apple articles than they did Android articles.
33. bucky (Posts: 2581; Member since: 30 Sep 2009)
i think they were uber conservative with an 8.5 if you ask me. they even said in the conclusion that it deserved a 9. Its a top notch smartphone.
41. Lucas777 (Posts: 2137; Member since: 06 Jan 2011)
hahahahahahhahahahahhaha if u think this site is pro-apple you are very diceived... do u ever read comments? its kinda like a huge andrroid storm with some apple fans and some various other people (wp7, bb, bada-lol) watching... no the iphone 4 was very diservent of a 9.5... it was literally the best phone for at least half a year....
45. Joshing4fun (Posts: 1236; Member since: 13 Aug 2010)
Seriously. I would never call this website "iPhonearena". This site definitely has way more android fans. Even some of the writers have mentioned that they prefer android, but respect iPhone. For every iPhone article, there are 10 android. Mostly because android has more phones.
63. NeXoS (Posts: 288; Member since: 03 May 2011)
Speaking of RE-HASHED DESIGN, the first iPhone 4 stole its design from the Garmin Nuvi after it won a design award!!!
20d7f00b294bd00b01cdcc541b&det ail=7398
How come iPhoneArena doesn't report that???????
51. HTCiscool (Posts: 449; Member since: 16 Jul 2011)
U r a fanboy idiot. This phone is actually quite good, you guys have to admit that while Android is more complex and customizeable, iOS is far more stable, the screen, while small is also a lot better than many efforts from Android manufacturers. Siri is an excellent idea, and the A5 chip smokes the Exynos as does the camera. Btw if you can find me lag on an iPhone 4S I will be completely shocked.
You can't deny that the iPhone 4 smoked the S**t out of everything Android released last year, except for maybe the Galaxy S, which is why they gave it a 9.5
Just because this thing is in the same shell doesn't mean it sucks, so stop wining around and accept that this thing is a good product.
2. Muhannad (Posts: 455; Member since: 20 Sep 2011)
8.5/10, I'm not surprised at all.
11. bobfreking55 (Posts: 866; Member since: 15 Jul 2011)
and they said they woud give it a nine/ten... pssshhhh. It's freakin outdated. It's like reviewing the nokia n95 when the galaxy s i9000 just arrived.
52. HTCiscool (Posts: 449; Member since: 16 Jul 2011)
How is it outdated?
1. Most powerful CPU-check
2. Most powerful GPU-check
3. Best camera-check
4. Most stable mobile OS-check
5. One of the best screens (Apart from AMOLED ones)-check
6. Smoothest web-browsing (no flash but who cares?)-check
I really hate it when Fandroids bash Apple
products for no absolute reason.
58. nick7237 (Posts: 5; Member since: 19 Oct 2011)
Most android fans have never used an iPhone for more than a few minutes so they can't really judge the phone. Android and WP7 would never exist if apple never created the iPhone, and android would probably not be as far as it is if Eric schmidt wouldn't of double crossed apple. Android would be as far as WP7 is right now. And who came out with the tablet first(apple), and who copied it (android). It's easy to see who the innovators are here and who copy's other companies. ICS copied a lot of iOS5 features.
It's obvious who sells more devices and repeatedly gets the best reviews. The iPhone 3GS came out with iOS3.0 and now has 5.0. I can't remember any android devices that have got two full point updates, even the nexus devices only get one update.
The 4S is a huge update internally.
4S: Dual core 800MHZ CPU/ Dual core SGX543mp2 GPU 512MB RAM
And a 64GB option.
AirPlay, wired mirroring (1080P) and AirPlay mirroring(720P) are some of the most simple and powerful features unique to ios devices. I could go on but I don't need to. Android users don't like iPhones cause their jealous.
250million iOS devices sold, each with satisfied customers.
61. tahnik (Posts: 188; Member since: 17 Jul 2011)
iphone has:
No Flash support in the web browser
No Facebook integration
No proper widgets for the lockscreen
No USB Mass storage mode for uploading content to the device
No haptics for the touchscreen
No Bluetooth file transfers to other phones
64. thebikerboi2 (Posts: 144; Member since: 01 Apr 2011)
dude you just proved this guys point about androiders not using an iphone for anything over a minute
76. gain1998 (Posts: 11; Member since: 23 Jun 2011)
I think you should probably know...
iPhone users don't necessarily care too much about Flash support... and in case you hadn't noticed this had been posted in the positive comment you negatively responded to.
iPhone users don't care about FB integration.
iPhone users don't care all too much about proper widgets for the lockscreen.
iPhone users don't care about USB Mass Storage mode for uploading content to the device
iPhone users don;t care about haptics for the touchscreen
iPhone users don't care about transferring files to other phones through Bluetooth
What iPhone users DO care about are reliable, dependable phones, with outstanding reputations. They're not looking for all these different features. And if you ARE looking for these features, then this is OBVIOUSLY not the phone for you. Keep looking.
67. RandomRobbieGuy (Posts: 4; Member since: 05 Nov 2011)
The iPhone is outdated. People buy and use it because they don't care about their phone. Or because everyone else has one. I have had every iPhone in all colors. (execpt the 4S) I keep buying them because i am used to them and know them just about inside and out. Nothing changes. OMG! SIRI....like for real. think about it in your daily life. I have the iPhone 4 and don't use voice control. You can never expect the newest and best tech from apple. I don't know why people are so attached to the iPhone. Android is amazing i have had one. Blackberry... no its not business like really at all......just because they have email. I am returning to blackberry for the keyboard. iPhone 4S is a piece of crap and not worth the upgrade.
Hey apple where is the keyboard.....oops
big nice screen.....nope
Annoying.....uh duh.
68. robinrisk (unregistered)
1. It is not the most powerfull CPU. Dual core @800Mhz is not better than the exynos at 1.2.
2. GPU, i do not know much about it, so i'll give you that one.
3. Best Camera? Best camera in an iPhone that is, there are several smartphones with a camera better or just as good as the iPhone's.
4.Most stable Mobile OS?. My photon has never given me any force closes, WP7, Blackberry and Symbian are just as stable.
5. One of the best screens. Not the best though, ain't it? SamoledHD FTW =)
6. Yeah.... without flash even the low end handsets have a smooth browsing experience. Plus, at 3.5 inches, it is not as confortable as in an Android device.
73. HTCiscool (Posts: 449; Member since: 16 Jul 2011)
1. Actually the dualcore A5 chip @ 800MHz is far more powerful than the Exynos in terms of I/O.
2. I am right
3. No the 4S\' camera really does beat everything else by a longshot
4. No they\'re not
5. you are probably right
6. Right again =)
82. Gdrye (Posts: 110; Member since: 02 Jan 2012)
samsung Galaxy has a quad core graphics processor, so i wouldnt let them have that one
85. TheDog700 (Posts: 1; Member since: 03 Apr 2012)
Time for the nine year olds to go to bed, the adults are talking.
Some of you probably do not know what software does. iOS is obviously not as laggy as android which is why you don't need a 1.5 ghz proccesor for it to run smoothly. Yes there are some great android smartphones out there. But the iPhone 4s functionality and preformance are on par or better than these other phones. For the average consumer, functionality is all that matters.
What I am saying is that you can have a 4ghz proccesor but if it has horrible software it won't be functional.
And for the record, the ppi on the iPhone 4s is currently the best on the market and the color accuracy is the best or one of the best on the market.
86. dmckay12 (Posts: 243; Member since: 25 Feb 2012)
Xperia S and HTC Rezound have highest PPI, while having bigger screens.
3. Tatperson (Posts: 58; Member since: 21 Oct 2011)
Great job phonearena, you were not so biased this time round. It didn't score higher than 9 points unlike other dual-core phones. Keep it up :)
20. henrickrw (Posts: 408; Member since: 16 Sep 2011)
I own both (The Galaxy S2 & the N95 8GB) - Beleive it or not, I still love my N95 8GB & it´s brand new still.
I agreed with your statement tough. It was time for Phonearena to judge the 4S how it deserved to be... A good phone but not the super...
4. Muhannad (Posts: 455; Member since: 20 Sep 2011)
Same phone from last year but they still charge you $700-$800 for the unlocked version.
21. henrickrw (Posts: 408; Member since: 16 Sep 2011)
That the other issue. Apple products are just too expensive dude. They are still charging 800...Even downhere in Latin America it´s more expensive than the GS2
5. arcq12 (Posts: 733; Member since: 13 Oct 2011)
should've been 8/10 because the looks and screen didn't budge.
46. Joshing4fun (Posts: 1236; Member since: 13 Aug 2010)
I agree. Those are the things people notice the most.
6. manuell3g (Posts: 66; Member since: 12 Aug 2011)
iphonearena to me were still biase. watch reviews on most android phones that dont come with any major changes or even the one they did on the galaxy note.the reviewer was talking as if he was so much disappointed in the product. yet you can feel the satisfactory in their voices when they review an iphone...they can bash android but to me even a midrange droid is still better than a highend iphone simply bcos of the os.android is just uhhh.
7. krysis (Posts: 76; Member since: 14 Dec 2009)
i think it more has to do with the fact that they don't get to review as many iphone's as android devices. so it's probably rather fun for them to get their hands on it, compared to say, an htc phone on at&t that has the same specs, hardware, etc. as an htc phone on sprint that they reviewed less than a month ago. the design may be different but i'm sure it can get rather repetitive. and this would be coming from an android user anxiously awaiting the galaxy nexus :)
8. Eingild (Posts: 203; Member since: 19 Apr 2011)
I'm somewhat surprised that PA gave this a score below 9.
14. cristhiansaid (Posts: 30; Member since: 25 Jun 2010)
Hey PhoneArena Why you didnt say in CONS
: Same OLDER Design, just like others phone review???
why ja???????????
example Sony ericcson ARC S......and sony ericcson ARC?
why???? why????
49. cristhiansaid (Posts: 30; Member since: 25 Jun 2010)
I want to ask those people that put me down in red.
Why? Is not the same design?? Is not the older design? I dont talking about beauty of design ok... but this is older design and a BIG CONS,
just like the others review, example, again, sony arc and sony arc S.
57. SleepingOz (unregistered)
you mad, bro?
60. cristhiansaid (Posts: 30; Member since: 25 Jun 2010)
jajajaj lol...
9. RORYREVOLUTION (Posts: 3108; Member since: 12 Jan 2010)
Great review exactly what the phone deserves. Its a decent upgrade but it's nothing mind blowing and wasn't worth the long wait. Anyone who has the 4 wont need to rush to upgrade to this.
10. dbparipsa (Posts: 20; Member since: 18 Oct 2011)
Well, I think the main reason why Apple couldn't bring a big breakthrough with this device is because of so-called patent war.
Last year, Apple had brought revolutionary iPhone 4 and it was just great because its making was not distracted by nonsense patent wars and lawsuits. This time around, Apple focused more on patent war than on making of iPhone. It wasted more time on blaming others of copying its ideas (even though it copied its 'innovative' notification bar from Android).
Thank God, Apple does not make aircrafts. If Apple was an aircraft manufacturer, I bet it would file a lawsuit against birds for infringing its 'flying technology patents'!
89. cbillupsfly80 (Posts: 2; Member since: 24 Oct 2012)
12. kshell1 (Posts: 1143; Member since: 05 Oct 2011)
iphone4s gets 8.5 the prime and razr will get 10 :D
13. ilia1986 (unregistered)
At last! An iPhone to get less than 9! Thankyou PhoneArena for finally proving that you are indeed objective in your reviews.
iPhone 4ass - the most underwheling iPhone yet. For an unbelievable price.
I'll wait for the SGS3 + ICS.
19. SuperAndroidEvo (Posts: 4837; Member since: 15 Apr 2011)
It was a fair review. The iPhone 4S is really no different than the iPhone 4. The dual-core on the iPhone 4S doesn't make a difference in performance. The games that will take advantage of the 800MHz A5 dual-core don't exist yet. Siri is cool but it got boring very quickly. So PhoneArena.com was spot on with the review. Kudos to PhoneArena.com!
15. warlockz (Posts: 156; Member since: 10 Oct 2011)
Iphone is starting to show its decline
16. maxican16 (Posts: 364; Member since: 29 Sep 2011)
Con: hipsters cannot express individuality since it's the exact same design as last years model. Confused and unsure where to turn, many cover their face in knitted caps.
88. li0nh3art (Posts: 28; Member since: 05 Aug 2012)
Yeah.. Even the concept phones are better than this crap design!
17. droidcandy13475 (Posts: 5; Member since: 17 Oct 2011)
who cares?
18. AKm007 (Posts: 108; Member since: 06 Sep 2011)
Isn't it a bit unfair that the Droid X2 got a negative point for being the same unchanged design. So did the torch. Here they just mention it in the article. Isn't that a bit biased?
55. cristhiansaid (Posts: 30; Member since: 25 Jun 2010)
is the same that a i wrote....and every body put me fingerdown.....
22. henrickrw (Posts: 408; Member since: 16 Sep 2011)
Dear Phonearena,
I know this have been one of the most difficult reviews of your entire history.
When you say:
Right now, we believe the Apple iPhone 4S is deserving a rating of 9/10, when we consider its overall quality, features and price, but we'll actually give it an 8.5, because it is only an incremental upgrade from last year's iPhone.
There is one thing we should have learned from this:
Apple Products are no longer the ALMIGHTY.... Samsung is their worst nightmare.
Good review guys
More to come soon..!!!
28. vette21man (Posts: 351; Member since: 06 Apr 2011)
I'm ready for the thumbs down.
I see the last statement in the article way differently...like this:
"We at PhoneArena know that Apple haters will whine if we give it a 9/10, so we'll go with the mob and rate it an 8.5/10."
Seriously? When did you start reviewing the current model to last year's model? What about people coming off contract wanting to upgrade? You are basically saying the iPhone 4 is a better phone. Now only monumental upgrades can achieve 9 and above scores. We should do this with the car industry then, too. "Well the new Honda Accord isn't that much of an upgrade compared to last year, even though it's one of the best in its class, we'll give it an 8.5/10."
I get that this is the mobile device industry, which is moving at a much faster pace than the car industry......if that's your reason...then say that!! Don't say you WOULD have given it a 9.
Are you really trying to appease Apple haters?...because every comment on this post agrees with the lower score, and then says, "Android FTW!!!" These are not objective viewers of tech, they are Android fanboys.
We are allowed to jeer/cheer in the comments as much as we want, but your review should be based on features, usability, and competitors' offerings. If those 3 food groups are met in your eyes, and you think it deserves a 9/10, then give it a 9/10!!
Seriously consider removing that entire last sentence from the article...or change your score to 9/10. I think that statement dilutes any integrity you have.
30. rayjones09 (Posts: 149; Member since: 16 Dec 2010)
These people are unsatisfiable. I'm sure there isn't much justified hatred towards Apple. I'm not an Apple fan in particular, but I must say they are now the benchmark (when it comes to mobile devices); as they have been for some time now.
37. taco50 (banned) (Posts: 5506; Member since: 08 Oct 2009)
Great points vette21man. I'm confused by that comment as well. If they think it deserves a 9 then it should score 9. If not score it what you think. PA is definitely starting to take the fanboys into account. Ever since Michael H came on board the bias here is picking up. It was a site already dominated by android trolls, but now the writers are actually deferring to them led by the android fanboy they hired as a writer.
Anyway 8.5 or 9 is somewhere close to a fair score. There's nothing mindblowing on this phone like the original iPhone or the iPhone 4 last year which introduced a new form factor, facetime and iOS 4. I'm going to stick with my 4 until next summer. By then LTE should be more mature and iPhone will probably add it.
I think the real test of this phone, as always, will be the consumer. If it's truly falling back we will see it in sales and user satisfaction ratings.
42. whatevs (Posts: 18; Member since: 17 Oct 2011)
you know, I've been on an iphone since it came out. about a year ago i kinda got bored with it and tried out android - galaxy line on verizon. had a fascinate, super amoled screen was nice. the phone would freeze, glitch, lag and reset itself constantly. turned it in for a droid charge. nice screen. phone continuously freezes glitches and lags,,, and resets itself, lol. after a year of this bullsh%t, I cannot wait to get back to the beautiful smooth sailing that is the iphone 4s. it comes in next week. this phone deserves a 10 on this website and you know it PA! Android = FAIL!! software not optimized to work the several junk hardware that litters carrier stores. sorry, i lived through it. go ahead and thumbs down me and leave your hate comments android trolls. peesky
47. vette21man (Posts: 351; Member since: 06 Apr 2011)
The thumbs down you received makes me think of another point...if someone thumbs you down, they should have to leave a short comment as to why. This ridiculous "thumbs-downing" is so childish, anyone can do it without a reason. I think you should have to explain yourself...or just get rid of the whole thumbs down, and leave the "Report" function.
48. bolaG (Posts: 468; Member since: 15 Aug 2011)
I don't know if this is your case but many android users end up with a glitchy and laggy phone because they don't know how to filter bad apps from good apps and probably never clean memory caches.
My sister has an Iphone3gs and its laggy as all hell now days and its never been jailbroken nor does she have a crap ton of apps. She's also had to change her screen twice from small waist high drops sense its made of glass...
Again its all up to the user for android to work properly. Shoot if you or I knew how to Rom, Boot, Kernel androids then sky would be the limit.
23. remixfa (Posts: 14255; Member since: 19 Dec 2008)
the review was fair.
I probably wouldnt have given it higher than an 8 concidering the small upgrade and rehash that it was, and especially when you compare it to its similarly priced competition like the SGS2.
25. adnan.d92 (Posts: 2; Member since: 21 Oct 2011)
whats the big idea of being a world phone?
every other phone outside the U.S. can be used anywhere in the world!
26. mukrenol (Posts: 90; Member since: 03 Sep 2011)
they cannot think of any other pro points...
coz there isn't that much
mobilesyurp pointed out that siri does not really work in canada
sad sad....i bet it will not really work in korea too
27. vette21man (Posts: 351; Member since: 06 Apr 2011)
In the pic comparing sizes of iPhone 4S, iPhone 4, SGSII, and EVO 3D, that side-profile pic of the 4S is not a 4S. There is no black band above the silent switch. Further, it's not a white 4S profile, as the front and back borders are black.
I came across this discrepancy when trying to see the 1mm height difference between the 4 and 4S. :-P
Disclaimer: I may or may not be extremely detail-oriented (anal).
29. vette21man (Posts: 351; Member since: 06 Apr 2011)
"Using our Sprint iPhone 4S unit, we're IMPRESSED with its unflattering data speeds, which gives us average upload and download speeds of 1.39 Mbit/s and 0.22 Mbit/s respectively."
I believe you mean, "NOT impressed"
31. vette21man (Posts: 351; Member since: 06 Apr 2011)
You mention the "...optional A/V adapter that connects to the handset via its dock port."
But you fail to mention anything in the entire review about AirPlay mirroring with AppleTV. This is one of the only features separating the 4S from the 4 (besides A5, camera, world phone, and antenna). Actually, it's a pretty awesome feature that no other phone has at all. Would have been nice to see that feature reviewed. Are you doing a separate article for this?
Rather than pay $40 for a HDMI adapter, pay $99 for an AppleTV that gives you more than just mirroring, but wireless music/video streaming, iTunes access, and a handful of other internet radio/video sites. Not to mention streaming your own photos/videos/music from your PC with a dead simple interface.
34. chunk1x (Posts: 248; Member since: 25 Jun 2011)
Phonearena is so brutal about its photo quality review that this is the reason why I love the site. They don't pretend that one phone is the best at everything. Engadget is an asshole in faking the results. I love the 1080p video in this model.


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Wednesday, April 3, 2013
Free wellness classes continue
Roper St. Francis Families for a Healthy Heart program teaches easy ways to be healthy and active. The program is offering a series of free wellness classes to be held at Howe Hall AIMS school in Goose Creek through April.
Sessions are planned for April 11 and April 27.
We The People meets Thursday
The Goose Creek We the People 9/12 Group will meet at 7 p.m. on April 4 at the Berkeley Electric Co-Op Building (2 Springhall Drive in Goose Creek). Greg Adams will be the guest speaker and two documentary videos are planned.
Taste of Goose Creek April 20
The Taste of Goose Creek will take place from 10 a.m. to 3 p.m. on Saturday, April 20 at Immaculate Conception Church (510 St James Avenue).
Irish, American, Italian, Filippino and Spanish foods, as well as chicken, barbecue and desserts will be featured. There will also be games, a photo booth, used book sale, live music and more.
Everyone is welcome.
VFW Steak Night continues
VFW Post 10256/Ladies Auxiliary at 104 Stephanie Drive in Goose Creek holds Steak Night on the fourth Saturday of each month from 6-8 p.m.
Dinner includes one rib-eye steak or chicken with baked potato, salad and a vegetable, and Texas toast. Cost is $10 eat-in, and $11 carryout. Guests are welcome.
Advance tickets may be purchased at the Post. For more information call (843) 824-6160.
NCHS reunion set for October
North Charleston High School's Class of 1973 will hold its 40th reunion on Saturday, Oct. 19 at the Hobcaw Yacht Club in Mt. Pleasant from 6 to 11 p.m. The ost is $40 per person.
Contact firstname.lastname@example.com to receive additional information and register to attend.
Relay for Life
Cane Bay High School is hosting several events leading up to the Lower Berkeley Relay for Life night, set for May 3-4 from 7 p.m. to 7 a.m. at the school.
• April 13: Bunco for Lower Berkeley Relay for Life, 6-9 p.m. Tickets are $10; call Brenda McDowell at (843) 696-3842 or Katherine Smith at the school, 899-8786.
• April 27: Golfing to Find a Cure Tournament at The Oaks Golf Club. To donate prize items, call 553-4141.
If you would like more information on the Lower Berkeley Relay of Life contact email@example.com.
OA meets Mondays
Overeaters Anonymous meets at 6 p.m. on Mondays at Immaculate Conception Catholic Church (510 St. James Avenue in Goose Creek), in room 4 of the All Ministries Building. Call (843) 577-9499 or visit www.oa.org for more information.
Free lunch served twice weekly
Free lunch is served every Wednesday and Friday to all comers from 11 a.m to 1 p.m. at the Goose Creek United Methodist Church fellowship hall.
The menu of the Lord's Ladle Cafe includes homemade soups, sandwiches, and desserts. On Wednesdays, free clothing is also available.
The Café is located at 142 Redbank Road. For more information, call the church office at 553-6842, or visit email@example.com.
GOP Breakfast Saturday
The Berkeley County Republican Party Breakfast will be held on Saturday, April 6 at American Legion Post 166 (116 Howe Hall Road in Goose Creek).
The guest speaker will be Rep. Brain White, Chairman of House Ways and Means Committee.
Breakfast ($6) will be served at 9 a.m. with the program beginning at 9:30. No membership is required and the public is invited to attend. For more information contact Nancy Corbin at (843) 688-4975.
Fleet Reserve meets monthly
The Fleet Reserve Association Lowcountry Branch 269 holds its monthly General Assembly meeting on the third Thursday of the month at 7 p.m. at 99 Wisteria Road in Goose Creek.
For more information, please contact the home at (843) 569-2692 or visit www.fra.org.
First Steps meets April 11
The Berkeley County First Steps Partnership Board encourages the public to attend its meeting at 6 p.m. on Thursday, April 11in the Berkeley County School District board room 229, East Main Street in Moncks Corner.
Berkeley County residents who attend the meeting can learn more about the results of the First Steps to School Readiness program in the county as well as future plans.
For further information contact Stephanie Olazabal at firstname.lastname@example.com, or by calling (843) 416-8277.
Reading Council meets April 11
The Berkeley Reading Council – the local chapter of the South Carolina International Reading Association – was recently honored by the national organization for the 22nd consecutive year for its work to promote reading in the community as well as schools.
The council's next meeting will be April 11 at Goose Creek City Hall at 6 p.m. when local youth will be honored for their writing prowess as part of the Young Writers' Awards.
The meeting is open to the public.
Chamber announces upcoming events
The Berkeley Chamber of Commerce has announced the following events:
• Thursday, April 4: Berkeley Chamber of Commerce Business Mixer, 5:30-7 p.m. at First Citizens Bank (212 East Main Street, Moncks Corner). Cost: members free, non-members $10.
• Thursday, April 11: Berkeley Chamber of Commerce Annual Meeting, 6:30 p.m. at the Daniel Island Club (600 Island Park Drive, Daniel Island). Cost: members $75, non-members $100.
• Friday, April 12: Berkeley Chamber of Commerce 2013 Teacher of the Year Breakfast, 7:30 a.m. at Trident Technical College, 7000 Rivers Avenue, Bldg. 920 North Charleston. Join the chamber as it recognizes Berkeley County's outstanding educators.
For all events, call 577-9549 or 761-8238 or register online at www.berkeleysc.org.
Alzheimer's support groups continue
The local Alzheimer's Association has three caregiver support groups in the area held at different locations on the second Monday of each month.
Locations are Metro North Church (5:30-6:30 p.m.) at 109 Central Avenue in Goose Creek; Moncks Corner Medical Center (11 a.m – noon) on N. Live Oak Drive, and the Otranto Road library (1:30 p.m. – 2:30 p.m.) in North Charleston.
For more information, please contact Cawana Tisdale at (843) 571-2641.
Safe boating course announced
Charleston Sail and Power Squadron will offer a safe boating course to the public at 8:30 a.m. on April 20, 8:30 a.m. at its headquarters building at 1376 Orange Grove Road.
The course covers such topics as rules of the road, required safety equipment, communications afloat, and personal watercraft safety. The course is $50 for adults, and $15 for a second person sharing the same materials. The course is free for youth aged 12-18.
For more information or to register contact Billy Lynes at (843) 312-2876 or email firstname.lastname@example.com.
Relay for Life May 3-4
The American Cancer Society Relay For Life is a 12-hour team event that brings people from local businesses, schools, churches and families together for a night under the stars while team members take turns walking or running around the track. Relay For Life of Lower Berkeley is having its event this year on May 3-4 from 7 p.m. to 7 a.m. at Cane Bay High School.
As a cancer survivor, you have something to celebrate! We invite you to show your courage and spirit. Join cancer survivors of all ages, their caregivers, and friends for a lap around the track during the Relay For Life Survivors' ceremony.
You do not have to be a member of a Relay team or pay a fee to be involved in any of the survivors' celebrations, but you do have to register.
Please register today at: www.relayforlife.org/lowerberkeleysc.
Goose Creek seeks food vendors
The City of Goose Creek will present its Second Annual Beach and Barbecue Festival on Saturday, April 27 from 4 - 7 p.m. on the grounds of the Marguerite H. Brown Municipal Center.
This free, family-friendly event will feature live music from Local Motion Party Band, a corn-hole tournament, and a kid's play area.
Barbecue vendors and other food vendors are needed. Interested vendors should complete an application and submit by Friday, April 5. Applications are available on the City's website at www.cityofgoosecreek.com.
For more information, call Barbara Nimocks at 569-4242.
© 2016 The Gazette an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


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Mocksville, NC -- Davie Hospital could see new life as training ground for future health care workers and a home for the Davie County Health Department.
According to The Business Journal, Officials with Davidson County Community College and Davie County are making plans for how to repurpose the county-owned hospital once services start being shifted to the new Wake Forest Baptist Health- West Campus beginning next year.
The hospital property offers the chance to introduce additional training programs that could funnel new workers into a broader section of the high demand health care industry.
The Business Journal


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DFV / Bota Box
John Garaventa, Senior Brand Manager at Delicato Family Vineyards, says, "The Gift Trees have been a wonderful added bonus to our annual program with the Arbor Day Foundation.
For the second year in a row, we have made trees available to our sales force for in-store demos which are handed out to consumers who purchase a Bota Box.
It allows us to get the word out about our partnership with the Arbor Day Foundation during Earth Day as well as provide our consumers with a nice takeaway item that fits our brand's message.
During March and April 2010, we conducted 75 demos and handed out 2,100 trees to consumers."


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It was 1998 and a then unknown Mila Kunis didn't quite know what to make of the news that she would have her first real kiss on camera with Ashton Kutcher, a model turned actor whom she'd only just met.
"I was like, 'Oh, he's so cute, it's the Calvin Klein model!' " the actress told PEOPLE in 2001. "Then I was like, 'I have to kiss him?' I was so nervous and uncomfortable. I had the biggest crush on him."
Kunis, who at the time was costarring with Kutcher on That '70s Show, spritzed herself with perfume the producers gave her to help mask her nerves. "I totally perfumed myself and I was like, 'Hey, I feel better about myself,' " she said.
But the way Kutcher remembered the scene, he was the one who was sweating.
"I'm the first guy she kissed? Oh my god, I had no idea!" said Kutcher, also in 2001. "I'm so glad I didn't know that or it would've been too much pressure."
Added Kutcher, "I was so nervous. She acted so cool. She seemed as if she'd done it a thousand times. I was the one with the butterflies in my stomach. I mean, here's this little girl and I have to kiss her. It was nerve-racking."
These days, the pair seem considerably more at ease with each other. Kutcher, 34, and Kunis, 28, spent the weekend together in the seaside town of Carpinteria, Calif.
And though Kunis calls reports that they're dating "absurd," a source tells PEOPLE the pals are "both single, having fun."
So how was that first kiss all those years ago?
"Ashton was so nice," recalled Kunis. "He just made jokes and gave me funny little compliments. He made me laugh."
Ashton Kutcher Was Mila Kunis's First Kiss
Donato Sardella/Getty


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Missing people found years later
POSTED: 09:08 AM PDT May 07, 2013 UPDATED: 11:00 PM PDT Aug 25, 2014
Five years ago today, Jaycee Dugard was found alive nearly 20 years after being kidnapped at age 11. She's a rare example of missing people found alive years later.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


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Top Definition
The lesser-known and actually more accurate name for McDonald's Chicken McNuggets. Focus groups revealed people were less likely to eat the donkey meat unless they called it chicken.
Gimme a #4 Donkey McNutSacks value meal with Coke to drink .... And sweet n' sour sauce.
di Muk Wang 29 ottobre 2006
Trending Now
Can you define these popular missing words?


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Lace up for Make-A-Wish Michigan: Walk For Wishes
Help make wishes come true for Michigan children battling life-threatening illnesses in our community.
Help make wishes come true for Michigan children battling life-threatening illnesses in our community.
Local 5-year old girl receives a big surprise, and a day to forget about Cancer.
Nothing says fall like a good cider. Enjoy these 5 cider recipes.
If you love the ABC television show Shark Tank, don't miss the chance to see 'Shark' Barbara Corcoran speak live in Grand Rapids.
Support your friend going through a divorce with a basket of helpful and comforting items.
Keep kids safe when they go back to school by helping them stay safe on the playground.
Maranda gives tips on organizing homework.
In The Image launched its 19th year of the S.H.O.E.S. program.
The be nice. program aims to prevent bullying and suicide.
MySchool@Kent allows high school students to complete their education in a non-traditional setting.
Staff at Jamestown Elementary School in Hudsonville work for weeks getting ready for new students.
There was no better way to end the Fifth Third Bank Summer Concerts at Meijer Gardens than with Tony Bennett's performance on Sunday.
Jordan is due with her first child on December 9, 2015. See her baby bump grow through these adorable photos!
Kids and teachers from across West Michigan head back to school (Sept 8, 2015). Check out our back to school gallery.
Maranda shows how to help your kids can get more sleep.
Take a break from the kitchen and head to one of these family-friendly restaurants in West Michigan.
Living with a roommate for college? Here are some tips to help you two get along for the entire school year.
Not taking advantage of time off work can increase your risk for heart disease.
Here are the shows heating up the screen this fall, on ABC.
Enjoy the last weekend of summer with these easy dishes using seasonal ingredients.
Baby's go through lots of stages. When your 8-12 month old starts waking in the night follow this advice.
"Hollywood Today LIVE" is hosted by a diverse cast who bring a contagious mix of chemistry and fireworks to in-studio guests and hot-button …
Try "glamping" for your next getaway!
Dr. Greg Mallis from Pine Rest says there are things parents can do to help with the transition back to school.
The Kent ISD superintendent has tips to have a successful school year.


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(a) There is established a special volunteer dental hygienist license for dental hygienists retired or retiring from the active practice of dental hygiene who wish to donate their expertise for the care and treatment of indigent and needy patients in the clinic setting of clinics organized, in whole or in part, for the delivery of health care services without charge. The special volunteer dental hygienist license shall be issued by the West Virginia Board of Dental Examiners to dental hygienists licensed or otherwise eligible for licensure under this article and the legislative rules promulgated hereunder without the payment of an application fee, license fee or renewal fee, shall be issued for the remainder of the licensing period, and renewed consistent with the boards other licensing requirements. The board shall develop application forms for the special license provided in this subsection which shall contain the dental hygienist's acknowledgment that:
(1) The dental hygienist's practice under the special volunteer dental hygienist license will be exclusively devoted to providing dental hygiene care to needy and indigent persons in West Virginia;
(2) The dental hygienist will not receive any payment or compensation, either direct or indirect, or have the expectation of any payment or compensation, for any dental hygiene services rendered under the special volunteer dental hygienist license;
(3) The dental hygienist will supply any supporting documentation that the board may reasonably require; and
(4) The dental hygienist agrees to continue to participate in continuing professional education as required by the board for the special volunteer dental hygienist.
(b) Any dental hygienist who renders any dental hygiene service to indigent and needy patients of a clinic organized, in whole or in part, for the delivery of health care services without charge under a special volunteer dental hygienist license authorized under subsection (a) of this section without payment or compensation or the expectation or promise of payment or compensation is immune from liability for any civil action arising out of any act or omission resulting from the rendering of the dental hygiene service at the clinic unless the act or omission was the result of the dental hygienist's gross negligence or willful misconduct. In order for the immunity under this subsection to apply, there must be a written agreement between the dental hygienist and the clinic pursuant to which the dental hygienist will provide voluntary uncompensated dental hygiene services under the control of the clinic to patients of the clinic before the rendering of any services by the dental hygienist at the clinic: Provided, That any clinic entering into such written agreement is required to maintain liability coverage of not less than one million dollars per occurrence.
(c) Notwithstanding the provisions of subsection (b) of this section, a clinic organized, in whole or in part, for the delivery of health care services without charge is not relieved from imputed liability for the negligent acts of a dental hygienist rendering voluntary dental hygiene services at or for the clinic under a special volunteer dental hygienist license authorized under subsection (a) of this section.
(d) For purposes of this section, "otherwise eligible for licensure" means the satisfaction of all the requirements for licensure as listed in section ten of this article and in the legislative rules promulgated thereunder, except the fee requirements of subdivision (6) of that section and of the legislative rules promulgated by the board relating to fees.
(e) Nothing in this section may be construed as requiring the board to issue a special volunteer dental hygienist license to any dental hygienist whose license is or has been subject to any disciplinary action or to any dental hygienist who has surrendered a license or caused such license to lapse, expire and become invalid in lieu of having a complaint initiated or other action taken against his or her dental hygienist license, or who has elected to place a dental hygienist license in inactive status in lieu of having a complaint initiated or other action taken against his or her license, or who has been denied a dental hygienist license.
(f) Any policy or contract of liability insurance providing coverage for liability sold, issued or delivered in this state to any dental hygienist covered under the provisions of this article shall be read so as to contain a provision or endorsement whereby the company issuing such policy waives or agrees not to assert as a defense on behalf of the policyholder or any beneficiary thereof, to any claim covered by the terms of such policy within the policy limits, the immunity from liability of the insured by reason of the care and treatment of needy and indigent patients by a dental hygienist who holds a special volunteer dental hygienist license.
Acts, 2013 Reg. Sess., Ch. 150.
Note: WV Code updated with legislation passed through the 2016 Regular Session
The West Virginia Code Online is an unofficial copy of the annotated WV Code, provided as a convenience. It has NOT been edited for publication, and is not in any way official or authoritative.


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1. Tobias Funke, former Analyst/Therapist (analrapist) turned "actor" from Arrested Development known for his latent homoerotic tendencies, deep denial, balding pate, and a known nevernude.
2. Anyone in serious self-denial about their true nature.
2. Anyone in serious self-denial about their true nature.
Yeah, Gena's still dating that Tobias... I wonder which one of them is in deeper denial?
tacostacos가 작성 2005년 11월 22일 (화)
Trending Now
Can you define these popular missing words?
Top Definition
A type/nickname for marijuana grown in South America and smuggled into the United States.
"Hey you, pass me some tobias!"
jy6793가 작성 2008년 07월 19일 (토)
Tobias is a super name for someone with a six pack and sexy abbs I want a Tobias more then anyhting he is funny creative brave selfless and strong physicly and mentally if I had a Tobias I would protect him and he would protect me all in all Tobias is what you should name a warrior who would fight for anything he believes in
"Damn that dudes hot"
"He's gotta be Tobias"
"Thought stealer"
"He's gotta be Tobias"
"Thought stealer"
myhairisonfireitoldyounottouse가 작성 2013년 03월 12일 (화)
An extremely attractive male named after the Greek God Tobius (the god of rippedness). Usually surrounded by extremely attractive females but very picky which is the reason Tobias will most likely be single or married.
omg, Tobias is dang hot
Tobyrrr00가 작성 2014년 11월 03일 (월)
To do a 180 turn with a waterjet while doing max speed. It involves great risk, and det driver is in serious danger for getting hurt.
"What happend to your leg?"
"I tried a tobias and failed."
"I tried a tobias and failed."
freddyman가 작성 2011년 08월 18일 (목)
A Tobias is usually a tall person, with a funny personality who cares for his peers. He can be anxious at times, but usually enjoys a laugh and has a joke around every now and then. A Tobias is usually very sporty and enjoys rugby mostly. They usually come from very complicated backgrounds.
He's called Tobias becuase he loves Rugby!
Katie Becks가 작성 2015년 12월 20일 (일)
Tobias is God in Asia. It has the body of a Pig surrounded by spiders and people believe that once he was a human that spent too much time among pigs in his early childhood until his body transformed into a pig.
"Bring me luck Tobias!"
lamartinm가 작성 2015년 05월 30일 (토)
When a person is called Tobias, it means he has a big black pussy killing cock (Spændt fjerder)
It is normally used in Denmark
It is normally used in Denmark
WOW look at his dick, he gotta be a Tobias
Geparden가 작성 2016년 05월 17일 (화)


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- Activities and crafts
- Announcements
- Author Visits
- Board Meetings
- Book Discussions
- Book Sales
- Classes and Computer Training
- Concerts
- Exhibits
- Films
- Gaming
- Lectures and Workshops
- Live Theatre
- Performances for Youth and Children
- Storytimes
- Tax Aide
- Youth Reading Programs
- Mobile Library Services
Basic Internet
Series: Computer Class
This class in basic Internet navigation covers understanding browsers and web addresses, searching, using menus and forms, and more.
- Prerequisite: Ability to use a mouse and keyboard; some familiarity with Windows.
Space is limited. Call 757.259.4050 to register.
For more information about WRL's computer classes and computer training, click here.
James City County
Room: eClic Room


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Celebrity Central / Top 25 Celebs
Penn Badgley
- 1999-2001
Soapy Roots
After performing in the Seattle Children's Theater, Badgley lands on an episode of Will & Grace. But it's his stint in Genoa City on The Young and the Restless as Phillip Chancellor IV that earns him a Young Artist Award nomination for Best Performance in a Daytime Series.
- 2002
The WB Rounds
In the WB's Do Over, a 15-year-old Badgley (pictured with costar Natasha Melnick) plays Joel, a 34-year-old reliving his life from the age of 14. Although the series fails, the network is good to Badgley. The teen actor appears in other short-lived series, including the 2004 family drama The Mountain and the 2006 sex-ed show The Bedford Diaries with Milo Ventimiglia. "It definitely felt like, 'What can we put Penn in this year because we want to keep him working for us?'" Badgley tells the New York Post in 2007. "There was a time when I felt a little cheesy, doing WB show after WB show – like it was repetitive."
- 2006
The Other Tucker
At 19, Badgley lands on the big screen in John Tucker Must Die, where he plays Scott, John Tucker's (played by Jesse Metcalfe) younger brother, who has a crush on Kate (played by Brittany Snow). The New York Times, which calls Badgley "wildly charismatic," says "The entire picture could hang on his cheekbones alone."
- 2007
XOXO, Gossip Girl
Surrounded by rich Manhattanites, Badgley plays Brooklyn outcast Dan Humphrey in the CW's Gossip Girl. "He casts himself out because he doesn't agree with the privileged kids' lifestyle," Badgley tells CosmoGIRL!, "but he's conflicted because he's in love with the girl who embodies all of that." The breakout hit costars Blake Lively, Leighton Meester, Chace Crawford, Ed Westwick and Taylor Momsen.
- 2008
The Boys Are Out
With Gossip Girl costars Crawford and Westwick, Badgley appears on Out. The gay and lesbian magazine calls the show a "cultural phenomenon whose early adopters weren't actually teenage girls but rather gay men trapped in arrested development or seeking to vicariously prolong their youth." Badgley says, "I'm kind of stunned by how seriously people in the media are taking our high-camp TV show."
GG Conquers New York
The cast of Gossip Girl, including newcomer Jessica Szohr, strips down for a tantalizing cover of New York magazine, which calls the teen soap, "the most awesomely awesome show ever." That week, the entire cast also lands on PEOPLE's Most Beautiful List. Tooting his castmates' horn, Badgley tells PEOPLE, "I assure you, we are all fun and charming as hell."
Blake & Penn Go Public
After months of swearing there's no romance with his Gossip Girl castmate Blake Lively, Badgley hits an afterparty following the Met's Costume Institute Gala with Lively on his arm. "I think she's incredible," he tells PEOPLE. "She's an amazing person and she's beautiful – so there's not a lot to dislike." But the real confirmation comes the following week when the pair is photographed canoodling in Cancun.
Badgley Spills the Details
The boys of Gossip Girl put their smoldering good looks to use on the November cover of Details. Badgley and costars Crawford and Westwick share their outrageous fan experiences, which seem destined to intensify as the second season nabs its highest ratings yet with 3.7 million viewers. "I get a lot of guys coming up to me who are like, 'Oh man, my wife loves the show,'" says Badgley. "Couple of drinks later they come up and they're like, 'You know what, I love Dan.' And they probably watch the show more than their wives."
- 2009
The Stepfather
Badgley stars as a reformed delinquent teen suspicious of his mom's fiancé in The Stepfather, a remake of the 1987 film. "It's a slower, simpler movie that draws you in and I think really terrifies you once you're in there," he tells MTV of the film which makes $11.5 million during its opening weekend. In 2010, he nabs another box office hit with the teen comedy Easy A.
- 2010
Penn & Blake's Split Decision
After dating for more than two years, Badgley and Lively call it quits, reps for both stars confirm to PEOPLE. The private actor once told Details magazine that mixing work and romance with his Gossip Girl costar was "wonderful and also something to grapple with."
Photo Credits
BIOGRAPHY (top to bottom): Everett Collection; Everett Collection; CBS; courtesy New York Magazine; NPG; Chuck Zlotnick/Columbia; INF
- Name
- Penn Badgley
- Date of Birth
- November 01, 1986
- Birth Place
- Baltimore, Md.
- Relationships
Zoe Kravitz, girlfriend (2011 to present)
Blake Lively, ex-girlfriend (2008 to 2010)


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If you are not 100% satisfied with your purchase, you may return it to Warehouse Skateboards within 30 days of your receipt date.
Powell Peralta Dragon Skull Skate Sticker
Show off your brand loyalty to Powell Peralta with this sweet decal. This sticker is great for skateboard decks, skate helmets, notebooks, water bottles, cars, UFOs, unicorns, and more. This is a brand new sticker made by the manufacturer—it's not a reprint or an unofficial copy. Get the real deal!
Looking for your Egift Card Shopping Cart? Click here.


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Macbeth: Director, Howard Davis; Designer, Chris Dyer; Photo, Donald Cooper (ahds,ac.uk./performing arts); 1983.
"[Macbeth] is played in near modern dress, in a cavernous steel-poled gymnasium dominated by two percussionists aloft armed with rattles and noisy contraptions. This unchanging space, and ironmongery has to make do as castle, wood, cave, heath and bedroom." John Barber, Daily Telegraph 17.8.83.Opening Date: 16 August 1983.
Curiously enough the eclectic modern style of this production approximated to an Elizabethan one's relation to then contemporary styles. HMR


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Become a Founding Member of the PFS Theater at the Roxy!
Everyone who made a contribution to the Philadelphia Film Society and the PFS Theater at the Roxy in 2013 will be recognized as a Founding Member. Memberships and gifts of $500 and below will be honored on the Roxy screens before each film. Contributions of $500 and above will be listed on a permanent plaque in the PFS Roxy Theater lobby.
Be apart of this historic year and join our community of film lovers with a PFS membership! New levels begin at $35 and include benefits to the annual Philadelphia Film Festival, Philadelphia Children's International Film Festival and the PFS Theater at the Roxy!


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Scientific name: Perizoma albulata
May - July. Britain and Ireland. A small white moth variably marked with grey and brown lines. Often found near Yellow Rattle and found on grassland, dune slacks and coastal shingle.
Typically the whitish forewing with extensive grey-brown cross-bands help to identify this moth. Paler forms can be found in some calcareous districts. A darker and obscurely marked race occurs on the Shetlands. Flies by day, from late afternoon to early dusk, sometimes in large numbers. Also flies after dark.
Size and Family
- Family – Carpets and Allies (Larentiines)
- Small Sized
Conservation status
- UK BAP: Research only
- Local (only found in some areas)
Particular Caterpillar Food Plants
Ripening seeds of Yellow Rattle.
- Countries – England, Wales, Scotland, Ireland
- Widely distributed in England, Wales and Scotland, including the Hebrides and Orkney. Also reported from the Isle of Man. Widely recorded, but with a thinly scattered distribution in Ireland.
Mainly found in lowland habitats and around the coast. Associated with grasslands, including calcareous grasslands, wet meadows, dune slacks, coastal shingle and some moorland.


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Father Kishore Kottana began serving as the new associate pastor at St. Mary Church July 1, and said "it is a blessing to be accepted and welcomed in a new community."
Kottana, who formerly was associate pastor at Maumee St. Joseph, was ordained a priest in the Toledo Diocese in 2009, and said he first felt the calling of God on his life when he was 4 years old.
Kottana said he was raised in a "good and faithful Catholic family," and his mother taught him and his four siblings Bible stories, the lives of the saints and the life of Jesus. His family is from India, he said, and in a biography released by St. Mary, Kottana said he "witnessed material poverty and sick families and the dying people on the streets." He said that exposure also was part of his calling to serve God as a priest.
Article Photos
"Deep inside, I wanted to be like a saint," he said.
"Come, follow me," was a prompting from God, he said, that was revealed to him, and Kottana said it took courage to listen to God's voice and follow him.
When Kottana was 23, he said, he heeded God's call, and began attending seminary in Rome. During those seven years, he said, he experienced Mass with Pope John Paul II and sang in the choir at St. Peter. His time in Rome, he said, "taught him to think universally."
Prior to attending seminary, Kottana said, he worked as a technician aboard warships and submarines.
After completing his seminary studies, Kottana came to the United States and served as a deacon at St. Joseph Parish in Paulding, St. Wendelin in Fostoria and St. Mary in Sandusky, after which he was ordained as a priest and assigned to Maumee St. Joseph, where he said he taught prekindergarten through eighth-grade students.
As associate pastor at St. Mary, Kottana now teaches at Calvert High School and said he feels the importance of "being there in the lives of students."
Young people are living in morally and financially challenging times, he said, and "their simplicity, their struggles and their hopes enrich me."
Kottana said he hopes to draw attention to holiness and faithfulness in the parish and at Calvert Catholic School. "I like to celebrate Masses and hear confessions," he said. Being God-centered is of great importance, he said, and stressed the importance of the sacraments in the Catholic faith.
Kottana said he hopes to see an increase in the number of people who faithfully attend Mass. He said during his time at St. Mary, his focus will be on having a "faithful prayer life and being there for the people (of the parish)."
Kottana said he is grateful to have Father Gary Walters, pastor at St. Mary, as "someone to look up to."
"Father Gary is very pastoral," he said, and "Tiffin is blessed to have him."
In addition to his responsibilities as associate pastor at St. Mary, Kottana said he enjoys running and playing soccer. He said he runs occasionally with the cross country team at Calvert, and played on the school's alumni soccer team.


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Quadruple Helices Appear To Have Role...
LC-MS Gains Favor Due To the...
Process Development Jobs Still the Most...
Adapting to Evolving Business Environments Is...
Bristol-Myers Squibb suspended its ongoing Phase II clinical study of a liver disease Hepatitis C drug just months after paying $2.5 billion to buy the company that developed it—a move that positions the company as an also-ran in the scramble among drug developers to bring to market treatments for the disease.
BMS stopped its trial on BMS-986094 (formerly INX-189), a nucleotide polymerase inhibitor or "nuc," after a patient who had received a 200 mg dose of the drug experienced heart failure, BMS spokeswoman Sonia Choi told several news outlets, including The Wall Street Journal and Bloomberg News.
"With patient safety as the priority, the Company is undertaking an immediate assessment of all patients in the study and following an evaluation of the patient data, will take appropriate actions," BMS said in a statement.
BMS acquired the drug in January when it bought Inhibitex, hoping to have a leg up on rival drug companies in developing a treatment for Hep C, which afflicts 170 million patients worldwide. Gilead Sciences said last week it plans to start a combination study of Hep C medicine GS-7977 with another drug in a trial of 800 patients starting in the fourth quarter, putting it on track to request U.S. regulatory approval in 2014. Abbott Laboratories earlier this year presented promising results from two Phase II studies for drug combinations aimed at Hep C, with additional data set to be presented later this year at the American Association for the Study of Liver Diseases meeting.
"We recommend that investors assume BMY's nuc is dead," Mark Schoenebaum, an analyst with ISI Group, said in a note to clients, adding a prediction that the stock would drop: "We expect to continue to see BMY lag the group as it has much if this year."
"This is perhaps yet another chink in the armor of a relatively expensive stock that has earned its multiple via R&D and business development successes," Schoenebaum added in the note, cited by Bloomberg along with a note to clients by Timothy Anderson, an analyst with Sanford C. Bernstein & Co.
Anderson cut his estimate of 2016 sales of Bristol-Myers' hepatitis C franchise from $2 billion to $1.2 billion, but also cautioned that more information was needed on the heart failure: "Sometimes companies take the conservative step of suspending dosing when new safety issues arise until the data can be analyzed and excessive harm can be ruled out."
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While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
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Ricker Polsdorfer, MD
The purpose of screening is early diagnosis and treatment. Screening tests are done for people without current symptoms, but who may be at high risk for certain diseases or conditions.
Screening Guidelines
There are no screening guidelines specifically for arrhythmias. However, if you are over the age of 50 and have a history of heart disease, it is recommended that you have regular check-ups, which should include an evaluation of your overall cardiovascular health.
(EKG) records the heart's activity by measuring electrical currents through the heart muscle. It can detect arrhythmias and damaged areas of the heart.
Atrial fibrillation. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated February 11, 2014. Accessed March 21, 2014.
Heart-health screenings. American Heart Association website. Available at: http://www.heart.org/HEARTORG/Conditions/More/ConsumerHealthCare/Heart-Health-Screenings_UCM_428687_Article.jsp. Updated October 15, 2014. Accessed March 21, 2014.
Kroenke K, Arrington ME, et al. The prevalence of symptoms in medical outpatients and the adequacy of therapy.
Arch Intern Med.
Mayou R, Sprigings D, et al. Characteristics of patients presenting to a cardiac clinic with palpitation.
Last reviewed December 2014 by Michael J. Fucci, DO
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.


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Kate Upton's Sports Illustrated Swimsuit Issue cover is very hot – but during her photo shoot in Antarctica, all the model could think about was the freezing cold.
"It was definitely the hardest shoot I've ever done," Upton, 20, tells PEOPLE. "The best as well – Antarctica is one of the most beautiful place I've ever been to. But I'm from Florida, so it was pretty painful."
The pain paid off, however: the perfect shot earned Upton her second consecutive SI cover, a distinction not seen since Tyra Banks covered back-to-back issues in 1996 and 1997.
"Everything about the picture is perfect," Swimsuit Issue editor MJ Day tells PEOPLE. "The light, the background, the suit. It's different from what we've done in past years, and it was an exciting moment for us to have those photos work out."
Exciting, because Day and her crew didn't know if they'd get any usable photos out of their Antarctica shoot – the first-ever fashion shoot on the continent.
"It was difficult," Day admits. "First of all, it's cold, even though we were there in summer. The windchill was sub-zero – the elements are really working against you." As the crew dealt with a whole host of issues – batteries dying in the cold, crazy weather rolling in and out – Upton was a total pro, Day says. "She never complained. She'd just say, 'Okay, let's go do it again.'"
Because of costs and the planning required to go to Antarctica – Day says this shoot was three years in the making – Upton was the only model taken to the faraway locale.
"I knew that if I needed to bury someone in clothing, I needed her physique and curves to come through," Day explains. "So to bring her was obvious: I knew I could put a one-piece on her and she wouldn't look flat, she'd still look voluptuous and healthy and shapely and sexy."
Upton's now-infamous Canada Goose Chilliwack Bomber coat, paired with white Letarte by Lisa Cabrinha bottoms, was an afterthought. "I figured, why not a coat?" Day says. "We threw it on, took maybe 100 frames, then moved on. Then that night, the photographer and I were looking at photos, and he said, 'I don't know, could this be it?' It just had that energy."
The only downside of the whole experience was the fact that the cover leaked on Friday, four days before it was supposed to be revealed. "I didn't get to tell Kate she was the cover, which was kind of sad," Day says. "I wanted to see the look on her face when she found out."
In fact, Upton found out from fans, via Twitter. But despite the early reveal, she's still beyond excited about the feat.
"It was an accomplishment just to get through the shoot," she says. "I didn't even think about the possibility of being the cover until after I thawed out a bit! But now it's like, wow – I actually went down there and was able to accomplish that. I'm part of history, and it's a great feeling."
Why Sports Illustrated Put Kate Upton on Its Cover – Again
Courtesy of Sports Illustrated


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Antony emerged with his musical ensemble Antony and the Johnsons in 1998. In 2005 Antony and the Johnsons won the UK's Mercury Prize for the album I am a Bird Now. Upon the release of 2009's The Crying Light, Ann Powers of the LA Times wrote "it's the most personal environmentalist statement possible, making an unforeseen connection between queer culture's identity politics and the green movement. As music, it's simply exquisite." In 2010, The Sun gave Swanlights 5 out of 5 stars and called Antony "one of the greatest living vocalists." The Daily News wrote, "in these intense and hushed pieces, he has created an exalted world entirely his own."
In 2006 Antony collaborated with film-maker Charles Atlas on TURNING, a concert and live video installation. The Guardian called TURNING, "fragile, life affirming, and truly wonderful (five stars)." Le Monde hailed TURNING at the Olympia in Paris as "Concert-manifeste transsexuel."
Since 2008, Antony has performed with symphonies throughout the world, including The London Symphony Orchestra at the Barbican, The Chamber Orchestra of Sydney at Sydney Opera House, The Orchestra of St. Luke's at Lincoln Center, and the Brooklyn Philharmonic at BAM. Antony and The Johnsons' presentation of The Crying Light at the Manchester Festival 2009 was included in Klaus Biesenbach's 100 Years: A History of Performance Art, at MoMA PS1. Last summer, Antony was the musical director and a performer in the critically lauded The Life and Death of Marina Abramovi , directed by Robert Wilson. This piece will tour Madrid, Amsterdam, Basel and Antwerp in Summer 2012.
In January 2012, the Museum of Modern Art presented Antony and the Johnsons' Swanlights to a sold out crowd at Radio City Music Hall in NYC. Antony transformed the space into the interior of a white mountain, bursting with crystals and fragmenting light, in collaboration with light artist Chris Levine, light designer Paul Normandale and set designer Carl Robertshaw. The NY Times says Antony's performance is like "Cries from the heart, crashing like waves".
Antony has collaborated with a wide-ranging group of artists and musicians including Björk, Yoko Ono, Laurie Anderson, CocoRosie, and Lou Reed. Reed has said, "When I first heard him I knew I was in the presence of an angel." Anderson adds, "Two words and he has broken your heart. When he sings it is the most exquisite thing you will hear in your life."
Antony is also a visual artist and has exhibited his drawings at Palais Des Beaux Arts in Belgium, Isis Gallery in London, Accademia Albertina in Turin and the Triennale in Milan. In 2009 he curated a group show entitled Six Eyes at Agnès B. Galerie Du Jour in Paris, which included work by Peter Hujar, Kiki Smith, and William Basinski. In October of 2010, Antony released a book of collages and drawings, also called Swanlights, published by Abrams Image. Antony's drawings were exhibited at the Hammer Museum in Los Angeles in Spring 2012, curated by James Elaine.
"A case could be made that Mr. Hegarty himself is following some uncharted lines as an artist and performer..." -New York Times [LESS]


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Video Card model numbers haven't make sense in years.
The lack of faith you both have in your GTX 260 is making my 8800GT cry.
It's actually just making a depressing wheezing sound, mostly.
Which is the way that it breathes.
Hey the number on this card is higher than mine. But it's slower. grr.


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Top Definition
Posega also known as a males left tecticle. Often refered to as a "possy" or the "poss'".
"Woh! Your posega is huge." said the girl.
po Tomz6831 Мај 12, 2009
Trending Now
Can you define these popular missing words?
a very funny lad who has the best jokes. what a lad. hes a hit with the babes.
the girl said omg posega that is so funny
po imalag Август 16, 2011


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Hallie E. Ford Center for Healthy Children & Families
"We have a real passion for children and families."
"Just as the most important work that you and I will ever do is within the walls of our homes, our research, which will result in positive change for parents and children, will take place behind the walls of our new home – the Hallie Ford Center. Home is the great gift that the Fords and other major donors have provided us – a place for great intellectual work and collaboration, a place for focused, strategic work, a place for spontaneous interaction, and above all, a place to inspire."
Made possible by the visionary gift of late Oregon philanthropist, Hallie Ford, the center opened Sept. 8, 2011, and is home to and a catalyst for holistic, interdisciplinary, collaborative research from across the College of Public Health and Human Sciences.
The spirit of collaboration also is evident in the physical design of the center, which features a three-story atrium and murals by Oregon artist Ron Mills de Pinyas, a professor of art at Linfield College.
Already home to a handful of large federally funded research projects, the center soon will be a "booming, buzzing place for grant-writing and publishing workshops, writing groups, colloquia and public events related to research, policy and practice," Settersten says. "We have big plans."
The Center is organized into four Research Cores
These cores build on the existing strengths of the College and serve as catalysts for collaborative research activity that will lead the College to new prominence in advancing science and serving the needs of the public.
Research Centers
- Center for Global Health
- Center for Healthy Aging Research
- Hallie E. Ford Center for Healthy Children & Families
- About the Center
- Center Leadership
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- Featured Researchers
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- Oregon Parenting Education
- Family Impact Seminar Series
- Campbell Lecture Series
- Affiliated Institutes, Centers, and Programs
- Resources for You
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- Donate to the Hallie E. Ford Center
- Contact the Center
- Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health


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Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
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Separate groups demonstrate that IL-23 stimulation of cytokine by TH17 cells drives encephalitogenicity.[fred goldstein-Fotolia.com]
Two research teams have separately implicated the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) as playing a central role in the IL-23-driven neuroinflammatory process that occurs in autoimmune diseases such as multiple sclerosis. The separate groups, led by scientists at Thomas Jefferson University in Philadelphia and the University of Zurich in Switzerland, have found that IL-23 induces IL-17-producing T helper cells (TH17) to express GM-CSF, and this cytokine plays a key role in their encephalitogenicity. The Thomas Jefferson team notes that although the role of GM-CSF in the pathology of multiple sclerosis is unknown, these latest studies in animal models suggest that blocking GM-CSF activity may represent a feasible therapeutic strategy for multiple sclerosis.
Both research teams report their findings in Nature Immunology. The paper by Thomas Jefferson Medical College chairman and professor Abdolmohamad Rostami, M.D., and colleagues is titled "The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF." The University of Zurich's Laura Codarri, Ph.D., and team describe their findings in a paper titled "RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation."
TH17 cells are widely believed to play a key role in autoimmune diseases of the CNS, with stimulation by IL-23 driving their encephalitogenicity, the researchers explain. However, to date, the mechanism behind this pathogenicity has remained unknown.
Dr. Rostami's team differentiated naive CD4+ T cells into TH17 cells by stimulating the cells with TGF-β and IL-6 (first stimulation), and then reactivated the cells in the presence of various cytokines (second stimulation). During the first stimulation, a fraction of IL-17A+ T cells expressed GM-CSF, and small amounts of GM-CSF were present in culture supernatants. In the second stimulation, treatment with IL-23 resulted in a higher frequency of GM-CSF+ TH17 cells than in cultures treated with TGF-β and IL-6 without added cytokines. IL-23 also resulted in significant augmentation of GM-CSF secretion. When they then injected the resulting IL-23-treated TH17 cells into sublethally irradiated recipient mice, the animals all developed severe experimental autoimmune encephalomyelitis (EAE) and died within seven days. In contrast, of the five mice injected with TH17 cells that had only been treated with TGF-β and IL-6, just two developed mild disease. They also found that adding IL-1β to IL-23 stimulation of the TH17 cells boosted production of both GM-CSF and IL-17A.
Significantly, when mice treated with an anti-GM-CSF antibody were injected with the IL-23-stimulated TH17 cells, they developed significantly milder disease with delayed onset relative to that of control mice, and all survived. Notably, the researchers add, IL-23-deficient mice developed EAE when exogenous IL-23 was delivered into the CNS, which indicates that IL-23 can act on already-developed TH17 cells.
Experimental data has previously shown that GM-CSF induces IL-23 in APCs, which in turn induces GM-CSF expression by TH17 cells, resulting in amplification of the inflammatory response, the authors note. TH1 cells also produced GM-CSF and responded to IL-1β by increasing GM-CSF production, which means they are another possible source of GM-CSF in EAE. However, the authors continue, it has also been shown that most CNS-infiltrating TH1 cells actually originate from TH17 cells. "A plausible model can be proposed in which TH17 cells and their TH1 progeny (ex-TH17 cells) are essential in EAE, which includes the bulk of GM-CSF production, whereas classical TH1 cells have a marginal role," Dr. Rostami's team claims. "We propose a positive feedback loop whereby IL-23 produced by APCs induces GM-CSF production by TH17 cells, which in turn stimulates IL-23 production in APCs. Greater and/or prolonged production of IL-23 results in stronger and longer lasting TH17 responses, causing more profound inflammation."
Dr. Codarri's team has similarly implicated IL-23, along with the transcription factor RORγt, as driving expression of GM-CSF in helper T cells. Their research in addition showed that IL-12, interferon-γ (IFN-γ), and IL-27 acted as negative regulators.
They found that mice injected with T helper triggered to produce GM-CSF had a significantly earlier onset of EAE and greater disease severity than did recipients of cells polarized to secrete IFN-γ or IL-17. Also concurring with the Jefferson team's findings, the Zurich team found that treating mice with an anti-GM-CSF antibody significantly reduced the severity of TH17 cell- or IFN-γ-secreting TH1 cell-mediated EAE. "This indicates that the secretion of GM-CSF is a critical feature for the encephalitogenicity of helper T cells in vivo regardless of whether they are polarized in vitro toward a TH17 or TH1 phenotype," the team states.
Significantly, T cells lacking GM-CSF completely failed to induce EAE, whereas the loss of IFN-γ or IL-17A only minimally impaired T cell pathogenicity. And in mice injected with T cells that only produced GM-CSF or IL-17A or IFN-γ, it was the animals receiving the GM-CSF-expressing cells that developed the most severe EAE. This importance of GM-CSF over IL-17A or IFN-γ was upheld in studies of T cells taken from mice which were doubly deficient in both IFN-γ and IL-17A. When these T cells were reactivated and transferred into wild-type recipient mice, the resulting disease profile in treated animals was the same as in mice administered with wild-type T cells.
Further tests in mice showed that GM-CSF acts at least in part to stimulate the infiltration of myeloid cells into the CNS. "Conceptually, the finding that of all known T cell cytokines, GM-CSF seems to be the only one absolutely essential for endowing T cells with pathogenic properties links invasion of the CNS by T cells with the activation and maturation of cells belonging to the myeloid lineage," the researchers concluded.
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'Bugnara' | Regular Fit, Mercerized Cotton Polo Shirt by BOSS
Style No. 50268004
Free Shipping
This polo shirt by BOSS is crafted from cotton with a mercerized finish for a strong, lustrous appearance. Contrast trim on the collar and four-button placket provide the finishing. A straight hem completes this casual, yet sophisticated look. Model is 6'2" with a 32" waist, 40" chest, and is wearing size L.
- Mercerized Four-button placket with contrast trim Spread collar with contrast trim Small logo tag near hem Regular fit 100% Cotton