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From the Departments of Pediatrics (Dr Davis), University of Washington School of Medicine, and Epidemiology (Dr Davis), University of Washington School of Public Health, Seattle, and the Center for Health Studies (Drs Davis, Bohlke, and Thompson and Ms Benson), Group Health Cooperative, Seattle; the Vaccine Safety and Development Branch (Drs Kramarz, Destefano, and Chen), National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga; the Center for Health Research (Dr Mullooly), Northwest Kaiser Permanente, Portland, Ore; the Division of Research (Drs Black and Shinefield and Mr Lewis), Kaiser Permanente of Northern California, Oakland; the UCLA Center for Vaccine Research (Dr Ward and Ms Eriksen), Harbor-UCLA Medical Center, Torrance; and the Kaiser-UCLA Vaccine Research Group (Dr Marcy), Southern California Kaiser Permanente, Panorama City.
A link between measles virus–containing vaccines and inflammatory bowel disease (IBD) has been suggested by recent studies.
To address whether receipt or timing of measles-containing vaccine (MCV) increases risk for IBD.
A case-control study.
Four large health maintenance organizations (HMOs) that are part of the Centers for Disease Control and Prevention's Vaccine Safety Datalink project.
Patients or Other Participants
A total of 155 persons with codes from International Classification of Diseases, Ninth Revision specific for IBD, born between 1958 and 1989 and enrolled from birth to the onset of disease, were identified. Up to 5 controls were matched by sex, HMO, and birth year.
Main Outcome Measures
Risk for IBD, Crohn's disease, and ulcerative colitis.
Past vaccination was not associated with an increased risk for Crohn's disease (odds ratio [OR] for measles-mumps-rubella vaccine [MMR], 0.4; 95% confidence interval [CI], 0.08-2.0), ulcerative colitis (OR, 0.8; 95% CI, 0.18-3.56), or IBD (OR, 0.59; 95% CI, 0.21-1.68). Risk for IBD was not increased among children vaccinated who were younger than 12 months (OR for MMR, 0.61; 95% CI, 0.15-2.45) or aged 12 to 18 months (OR, 0.86; 95% CI, 0.28-2.59) relative to unvaccinated children. Children vaccinated with MMR who were older than 18 months were at significantly decreased risk for IBD (OR, 0.16; 95% CI, 0.04-0.68). Neither past vaccination nor age at vaccination with other MCV was associated with increased risk for Crohn's disease, ulcerative colitis, or IBD. Risk for Crohn's disease, ulcerative colitis, or IBD was not elevated in the time immediately following vaccination with either vaccine.
Vaccination with MMR or other MCV, or the timing of vaccination early in life, did not increase the risk for IBD.
CONCERN about a possible link between measles virus–containing vaccines and inflammatory bowel disease (IBD) was brought to the forefront in 1995 when a study in the United Kingdom by Thompson et al1 suggested that measles virus–containing vaccine recipients had an up to 3-fold increased risk for subsequently developing Crohn's disease and ulcerative colitis. This concern was further heightened when Wakefield et al2 published a case series report of 12 children with nonspecific colitis, ileal-lymphoid nodular hyperplasia, and developmental disorders in whom symptoms were reported to have begun shortly after receipt of measles-containing vaccine (MCV).
While these studies have been questioned on methodological grounds, there has been considerable public interest and media attention focused on the safety of measles-mumps-rubella vaccine (MMR).3,4 Following these early reports, vaccination coverage rates for MMR dropped in the United Kingdom, raising concern about the potential for future outbreaks of these vaccine-preventable diseases.5,6
We studied whether MMR or other MCVs increase the risk for IBD using data from the Vaccine Safety Datalink (VSD) project, a collaborative project coordinated by the Centers for Disease Control and Prevention, Atlanta, Ga. The VSD incorporates data from 4 large health maintenance organizations (HMOs) in the United States and captures approximately 2% of all children in the US population younger than age 7 years. Our study focused on a series of questions: Was the age of first vaccination with MMR or other MCV, or receipt of vaccination itself, associated with an increased risk for Crohn's disease or ulcerative colitis later in life? Was receipt of MMR or other MCV associated with the acute onset of disease shortly following vaccination?
This study was carried out in the 4 HMOs of the VSD: (1) Group Health Cooperative, Seattle, Wash; (2) Kaiser Permanente of Northern California, Oakland; (3) Kaiser Permanente Northwest, Portland, Ore; and (4) Southern California Kaiser Permanente, Los Angeles. The VSD project was started in 1991, and the computerized medical databases at each HMO include information on vaccinations and hospitalizations. Information on outpatient visit encounters and emergency department visits are available for 3 of the HMOs.
We selected potential cases for medical record review by identifying persons with International Classification of Diseases, Ninth Revision (ICD-9) codes specific for Crohn's disease, ulcerative colitis, and idiopathic proctocolitis (ICD-9 codes 555 and 556) in the computerized databases. At 3 sites, we drew our study sample from the population of HMO members born between 1958 (when membership files were first available) and 1989. At 1 site, case and control selection was limited to people born after 1979 since automated membership data were not available prior to that year. At all 4 HMOs, cases were ascertained from hospital databases covering hospital admissions. Outpatient visits, emergency department visits, and urgent care clinic visits were ascertained from 3 HMOs; the earliest dates of case ascertainment from these respective databases were determined by the year the respective databases (eg, outpatient visits) were created. Because outpatient, emergency department, and urgent care clinic databases were not available at 1 HMO, only hospitalized cases were ascertained at this site.
To be included in our sample, cases and controls had to be enrolled from age 6 months up to the index date (the first date of disease diagnosis or symptoms for cases) or reference date for controls. For both cases and controls, we allowed up to 6 months of continuous disenrollment at any time during life to account for transient lapses in insurance coverage. For each case, we matched up to 5 controls according to sex, HMO, and birth year. The reference date of each control was established as the date that the disease was diagnosed for their matched case.
To accurately capture information on exposure to first MMR or other MCV, we limited our selection of study subjects, as described in the previous section, to patients enrolled for the entire period between 6 months of age and disease onset (for cases) or reference date (for controls). The entire medical record for cases and controls was abstracted to collect information on vaccination history with all types of MCVs. Information on vaccines administered in all health care settings was collected. A second MMR vaccination is recommended either at age 4 to 6 years or 10 to 12 years, but these vaccinations were not analyzed in the current study.
Trained medical record abstractors at each HMO reviewed medical records using a standardized instrument. Cases were classified according to type of disease (Crohn's, ulcerative colitis/proctitis, or IBD unspecified) and by certainty of diagnosis. We defined cases of "definite IBD" as persons diagnosed with IBD by a gastroenterologist at one of the HMOs who had at least 1 sign or symptom compatible with IBD (such as bloody stool and/or bloody diarrhea or severe and/or recurrent abdominal pain) recorded and a diagnostic test result (such as biopsy with pathology specimen, colonoscopy, or sigmoidoscopy) consistent with IBD. Cases were defined as having "probable IBD" if the diagnosis of IBD was made by either an HMO nongastroenterologist physician or a gastroenterologist outside the HMO, there was at least 1 sign or symptom compatible with IBD, and there was a diagnostic test result consistent with IBD. Potential subjects with possible or questionable IBD who did not meet these criteria were excluded from further study.
We used conditional logistic regression to estimate the strength of association between vaccination and disease, while accounting for the matching and enrollment criteria. In all analyses we further adjusted for race, where race was categorized as white (reference category, including Hispanics and non-Hispanics), African American, and other/unknown.
We excluded cases categorized as "possible" or "questionable" from all analyses. Separate analyses were performed on datasets that were limited to definite and probable cases combined or of definite cases only. Because the results from these analyses did not differ appreciably, we present only the results on the larger dataset of definite and probable cases combined.
Finally, we performed analyses with 2 different onset dates. For the analysis of whether receipt of vaccination was associated with an increased risk for IBD, Crohn's disease, or ulcerative colitis, we used as the onset date the first date a diagnosis was made by a physician. The analysis of whether vaccination was associated with the acute onset of symptoms consistent with IBD, Crohn's disease, or ulcerative colitis was dependent on using the onset date of first symptoms rather than the date of first diagnosis (which might lag symptom onset by months). Therefore, for this part of the analysis, we used the patient's first reported symptoms as the onset date. This lowered our case number by a small amount because not all cases with a known date of first diagnosis had a specified date of symptom onset in the medical record.
There was a total of 155 cases of IBD. Of these 155 cases, 152 were either definite or probable cases, while 3 were listed as possible or questionable. After excluding the latter 3 cases, along with 7 that lacked a clearly discernible diagnosis and symptom onset date, 2 cases of IBD unspecified, and 1 case with a late age of vaccination (>10 years), there was a total of 142 cases for the analysis of timing of vaccination and diagnosis of IBD.
Of these 142 cases, there were 75 cases of Crohn's disease and 67 cases of ulcerative colitis (Table 1). There was a slight excess of cases classified as white or African American compared with controls. Overall, 52% of both cases and controls, respectively, were female, and 58% of cases were diagnosed between age 11 and 19 years, with few cases being diagnosed either after age 25 years or before age 5 years.
Among all cases (n = 142), 94 (66%) had been vaccinated with MMR, 38 (27%) with other MCV, and 10 (7%) had never been vaccinated with either. Among the controls (n = 432), 300 (69%) had been vaccinated with MMR, 109 (25%) with other MCV, and 23 (5%) had never been vaccinated with either. There were 13 cases that did not have a clearly demarcated first date of symptoms, leaving a total of 129 cases for the separate analysis of vaccination and acute symptom onset.
There were no differences in the lag between vaccination with MMR or other MCV and the case index date (mean and median time between vaccination and onset of symptoms of 143.4 and 136.3 months, respectively) or the control reference date (mean and median time between vaccination and reference date of 143.0 and 136.7 months, respectively). As given in Table 2, cases of Crohn's disease, ulcerative colitis, or of all IBD combined were no more likely than controls to have ever been vaccinated.
Vaccination with MMR or other MCV was most common for both cases and controls who were 12 to 18 months old (Table 3). Cases of Crohn's disease, ulcerative colitis, or all IBD combined were no more likely than controls to have been vaccinated while younger than 12 months with either MMR or other MCV (Table 3). Similarly, cases of IBD, Crohn's disease, or ulcerative colitis were no more likely than controls to have been vaccinated at age 12 to 18 months or after age 18 months. Cases of all IBD combined were less likely to have ever been vaccinated with MMR after age 18 months than controls. This decrease was present but not statistically significant when cases were restricted to Crohn's disease or ulcerative colitis and analyzed separately. A significant decrease was not found for vaccination with other MCV after age 18 months.
The analysis of vaccination and the acute onset of symptoms of IBD revealed no cases of Crohn's disease or ulcerative colitis who were vaccinated in the 2- or 4-month time period just prior to the first symptoms. One case of Crohn's disease (1.5% of cases with defined onset of symptoms) was vaccinated with MMR within the 6-month time window prior to first symptoms, compared with 2 of the controls (1.0%) (odds ratio [OR], 1.86; 95% confidence interval [CI], 0.09-39.4 for Crohn's disease in the 6 months following vaccination). In the year prior to onset of symptoms, there was 1 case (the same that was exposed within 6 months) of Crohn's disease who was vaccinated with MMR (1.5%) and 3 controls (1.4%) (OR, 0.72; 95% CI, 0.06-8.29 for Crohn's disease in the 12 months following vaccination). Overall, there were no statistically significant elevations in risk for developing symptoms of Crohn's disease, ulcerative colitis, or all IBD together in the 2, 4, 6, or 12 months following vaccination with either MMR or other MCV.
In this population-based study of IBD at 4 large HMOs, we found no evidence that vaccination with MMR or other MCV, or that the age of vaccination early in life, was associated with an increased risk for development of IBD. In addition, we did not find evidence that MMR or other MCV acutely triggers the onset of either ulcerative colitis/proctitis or Crohn's disease.
This study was performed to address concerns raised by others regarding whether MMR is associated with an increased risk for either IBD or nonspecific colitis.1,2 Because MMR coverage in the US pediatric population is currently greater than 90% and vaccination with MMR is generally required for school attendance, a link with a serious chronic condition such as IBD would understandably raise widespread concern and would lead to questions about the safety of the currently recommended vaccination schedule for children. In the first study to suggest a possible association,1 a cohort of children aged 10 to 24 months were enrolled in a 1964 United Kingdom Medical Research Council vaccine trial of the Schwarz strain (derived from the Enders-Edmonston B strain) and followed through 1994. Children in this cohort were compared with a group of presumably nonvaccinated children in the National Child Development Study, a longitudinal study of children born in a single week in 1958. Among vaccinated children, the rate of reported Crohn's disease was 3-fold higher (relative risk [RR], 3.01; 95% CI, 1.45-6.23), and ulcerative colitis 2.5-fold higher (RR, 2.53; 95% CI, 1.15-5.58), than in the National Child Development Study comparison group.
These findings by Thompson et al1 were questioned most seriously because the method of disease ascertainment differed considerably between the 2 cohorts.3,4 The ascertainment of disease among the vaccinated children relied on questions specifically focused on gastrointestinal disease, while the unvaccinated group was asked about long-standing illnesses or disabilities. In addition, follow-up among the vaccinated group was approximately half that of the unvaccinated cohort, raising the possibility for biased response rates related to disease status. As a result, it was not clear whether the observed relationship between measles vaccine and IBD was due to the vaccine itself or to study design limitations.
The study by Wakefield et al2 did not look specifically at IBD but focused on a group of 12 children with a complex of nonspecific colitis, ileolymphoid hyperplasia, and pervasive developmental disability, in which most but not all reported that symptoms began following vaccination with an MCV. Of these 12 children, 6 had gastrointestinal symptoms, and 11 had abnormal histological findings in ileum and colon biopsy specimens (most commonly of nonspecific colitis and lymphoid hyperplasia). This study was questioned owing to lack of specification of the source population, making it impossible to determine whether vaccination was more common among these cases than among a comparable set of children without disease. Because MMR is given to approximately 600 000 children yearly in the United Kingdom, some cases of disease will likely follow vaccine temporally, although not necessarily as a result of cause and effect.7 Others questioned whether the gastrointestinal findings were unusual or represented nonspecific findings common in the age group studied.8
Several other studies have subsequently addressed the risk for IBD following MCV. A case-control study by Feeney et al9 from the United Kingdom looked at 140 patients with IBD born after 1968, matched to 280 controls by age, sex, and location. No increased risk was found for either Crohn's disease (OR, 1.08; 95% CI, 0.6-1.9) or ulcerative colitis (OR, 0.84; 95% CI, 0.4-1.6) among children receiving measles vaccine compared with unvaccinated children. Other data by Morris et al10 on a national longitudinal study of children born in the United Kingdom found no increased risk for Crohn's disease or ulcerative colitis by age 25 to 26 years associated with measles vaccination. Only sparse details were reported, but there were no significantly increased risks (Crohn's disease: RR, 1.21; 95% CI, 0.5-2.9; ulcerative colitis: RR, 1.31; 95% CI, 0.47-3.7; and IBD: RR, 1.25; 95% CI, 0.64-2.43).
Multiple ecological analyses have also shown no apparent increase in IBD following the introduction of, or increased use of, MMR. In one study, Miller and Waight11 used computerized hospital discharge statistics from 1992 through 1996 to look for evidence of an increase in Crohn's disease subsequent to a 1994 national measles-rubella vaccination campaign aimed at school-aged children. Although the follow-up time was limited to only the first 16 months following vaccination, there was no apparent increase in the rate of hospital admissions for Crohn's disease and hence no suggestion that MMR triggered the onset of symptoms as suggested in the study by Wakefield et al.2
In a second study, Pebody et al12 used Finnish data and contrasted the rate of Crohn's disease with the proportion of the population receiving measles vaccine. Although there was an increase over time in the proportion of the population receiving 1 or more doses of measles virus vaccine, the rate of Crohn's disease remained stable among 2 age groups of children and adolescents aged 0 to 14 years and adolescents and young adults aged 15 to 24 years. Finally, a study by Hermon-Taylor et al13 contrasted the annual incidence of Crohn's disease at 3 United Kingdom centers (south Wales, Derby, and northeast Scotland) with the introduction of measles vaccine and MMR. In this study there was a marked rise in the rate of Crohn's disease over the study period, but the increased rate of disease predated introduction of the measles vaccine by approximately 20 years.
A number of studies have attempted to find evidence of persistent measles virus genome in pathology specimens obtained from patients with IBD. These investigations were prompted by a report of measles virus nucleocapsid protein found in 13 of 15 patients with Crohn's disease.14 Most subsequent studies by Afzal et al15 on 19 patients with IBD, by Chadwick et al16 on 20 cases, and by Iizuka et al17 on 21 cases have failed to replicate these findings, arguing that measles virus genome is not present in the gut mucosa of patients with Crohn's disease or ulcerative colitis. However, a recent study by Kawashima et al18 detected measles genomic RNA in peripheral mononuclear cells in 1 of 8 cases of Crohn's disease and 1 of 3 with ulcerative colitis but no measles RNA in 8 subjects with subacute sclerosing panencephalitis, systemic lupus erythematosus, or HIV (human immunodeficiency virus) infection. This latter study did not examine intestinal pathology specimens.
There are some unique aspects to our study that deserve mention. First, previous studies of the relationship between measles vaccination and IBD have been conducted on populations outside of the United States. This is the first study of MMR and other MCVs and IBD used historically and presently in the United States. Second, that we did not find a relationship between MMR vaccine and IBD argues against the suggestion that concurrent exposure to measles and mumps antigens increases the risk for IBD19 and against the need to deliver these vaccinations as individual antigens.20 Third, this study uses information from a population-based group of HMO members and was therefore likely free from the biases that might occur in a study that relied on self-referred patients or patients studied specifically because symptoms might have occurred following vaccination. Finally, our study included only patients enrolled from (or shortly after) birth up to the time of disease or the similar age for controls, and we reviewed each patient's medical record to ascertain vaccination status. Consequently, the completeness and quality of information on the timing and type of vaccine received is likely to be good. Because we were able to ascertain the timing of the first symptoms and date of first diagnosis of disease from the outpatient medical records at each HMO, we were able to calculate an unbiased relationship between receipt of vaccination and disease onset.
There are some limitations to our study. We included only patients with a physician diagnosis (usually a gastroenterologist) of IBD, and we have the inherent limitations of diagnostic accuracy in a retrospective study. We have little information on children or adults who had nonspecific colitis that did not eventually lead to a diagnosis of IBD. Nevertheless, our study provides evidence against the hypothesis that MMR or other MCV leads to IBD. Another limitation to our study concerned power. We were able to effectively rule out associations larger than 2-fold between ever being vaccinated with MMR and developing IBD and associations larger than 3-fold between vaccination with other MCV and IBD. However, we had a limited sample size from which to look at the independent associations between vaccination and either Crohn's disease or ulcerative colitis (Table 2) or at the relationship between timing of vaccination early in life and subsequent risk for Crohn's disease or ulcerative colitis (Table 3).
There has been recent interest in the role of early exposure to measles virus and subsequent risk for development of IBD. A few studies have suggested that intrauterine or early-in-life exposure to infectious agents or measles virus may lead to an increased risk for IBD.21,22 Although we collected information on intrauterine and early-in-life measles exposure, we did not identify any mothers of case or control subjects who were noted to have first trimester measles infection. In addition, only 1 case of IBD and 2 controls had had measles infection. These small numbers precluded analysis of the relationship between measles infection and subsequent development of IBD; however, if such a risk does exist, the magnitude must be too small to identify accurately with a study of our size.
Finally, it is important to recognize that the apparent protective effect against IBD of primary vaccination with MMR after 18 months of age was not an a priori hypothesis of ours, and a similar finding was not seen among children vaccinated after age 18 months with other MCV. If subsequent studies are conducted on the relationship between IBD and primary vaccination, attention should be paid to the risk among children vaccinated after age 18 months with MMR.
In conclusion, our study of IBD using a population-based sample of cases from 4 large HMOs did not find evidence of an elevated risk for disease following vaccination with MMR or other MCV.
Accepted for publication December 28, 2000.
This study was supported by contract 200-95-0947 (the VSD [Vaccine Safety Datalink] project) from the Centers for Disease Control and Prevention.
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga: Frank DeStefano, MD, MPH; Robert T. Chen, MD; John Glasser, PhD, MPH; Philip H. Rhodes, PhD; Piotr Kramarz, MD; Thomas Verstraeten, MD; David Walker, MPH; Catherine Okoro
Group Health Cooperative, Seattle, Wash: Robert S. Thompson, MD; Robert L. Davis, MD, MPH; Lisa A. Jackson, MD, MPH; Patti Benson, MPH; William Barlow, PhD; Kari Bohlke, ScD; Paula Lee Poy; David Rubanowice; Ann Zavitkovsky, MPH; Jo Ann Habakangas; Darren Malais; Wendy Rogers; Christi Hanson; Onchee Yu, MS; Viviana Rebolledo
Kaiser Permanente Northwest Region, Portland, Ore: John P. Mullooly, PhD; Julie E. Maher, PhD; Sheila Weinman, PhD; Lois Drew, BA; Jill Mesa; Kim Olson; Heather Houston, RN; Colleen Chun, MD; Steven Gancher, MD; John A. Pearson, MD; Jerry Slepak, MD; Alan Bauck, BS; Teresa Kimes, MS; Joseph Murphy, BA; Nadia Redmond, MSPH; Karen Riedlinger, MPH; Carol Sullivan; Gayle Thomas-Monk
Kaiser Permanente of Northern California, Oakland: Steven B. Black, MD; Henry R. Shinefield, MD; Paula Ray, MPH; Edwin Lewis, MPH; Bruce H. Fireman, MA; Joan Schwalbe; Ajit De Silva; Patti Hallam
Center for Vaccine Research, Harbor-UCLA Medical Center, Torrance, Calif: Joel I. Ward, MD; Connie M. Vadheim, PhD; Hang Lee, PhD; Jennie Jing, MA; Nancy Goff
Southern California Kaiser Permanente, Los Angeles: S. Michael Marcy, MD; Marlene Lugg, DrPH
Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md: M. Miles Braun, MD, MPH; Robert P. Wise, MD, MPH; Robert Ball, MD, MPH
Division of Vaccine Injury Compensation, Health Resources and Services Administration, Rockville: Vito Caserta, MD, MPH; Geoffrey Evans, MD
Corresponding author and reprints: Robert L. Davis, MD, MPH, Immunization Studies Program, Center for Health Studies Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101-1448.
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wake up, go work out, tan, dry cleaners, go home, have t- shirt time, get wasted at a club, and to end things bring a girl home unless she is a grenade and smash her.
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Kalobios Pharmaceuticals inked a research and commercial agreement for the use of BioWa and Lonza's Potelligent® CHOK1SV cell line for the development and production of its Humaneered® antibody products. Launched in 2009, the Potelligent CHOK1SV cell line for manufacturing recombinant antibodies combines BioWa's Potelligent engineered glycosylation technology for generating fucose-free antibodies with Lonza's GS Gene Expression System™.
Lonza and BioWa claim the resulting cell line enables the production of recombinant antibodies that exhibit enhanced antibody-dependent cellular cytotoxicity, and potent cytotoxic effects even when their target antigen is at low density. Resulting antibodies are also effective in whole blood, the firms add. Daiichi Sankyo was the first company to announce the Potelligent CHOK1SV cell line back in June 2010.
Kalobios is exploiting its Humaneering technology to develop antibody therapeutics for a range of diseases. It says the platform has been designed to address current issues associated with antibody engineering such as specificity, affinity, and immunogenicity, and also to tackle downstream processing issues associated with antibody R&D such as solubility, expression, and aggregation. Kalobios claims the overall process is fast and produces antibodies close to human germ-line in sequence while retaining the specificity and improving the affinity of the reference antibody.
The firm's lead KB001 antibody for the treatment of Pseudomonas aeurginosa infection, partnered with Sanofi Pasteur, is a PEGylated antibody Fab' fragment designed to bind to the PcrV component of the organism's type three secretion system (TTSS) and inhibit its activity. Phase I/II studies have been completed in both in cystic fibrosis patients and intensive care patients on ventilators.
Clinical-stage candidate KB002/003 is an anti-GM-CSF program for the potential treatment of inflammatory diseases. KB002 and KB003 are both engineered human IgG1κ antibodies targeting GM-CSF. KB002, the precursor to KB003, is a first-in-class chimeric anti-GM-CSF antibody that Kalobios used for initial human proof-of-concept studies. Phase I/II studies in patients with rheumatoid arthritis and persistent asthma have been completed. KB003 is what Kalobios believes is a best-in-class Humaneered anti-GM-CSF antibody designed to minimize immunogenicity for chronic use in broad populations. KB003 will be used for all future development. KaloBios recently initiated a multidose Phase IIb trial with KB003, and is in addition in potential partnership discussions for the program.
A third oncology candidate, KB004, is a Phase I-stage Humaneered IgG1κ antibody targeting the EphA3 receptor tyrosine kinase. Kalobios believes the antibody has the potential to kill tumors through a number of distinct mechanisms including direct apoptosis of tumor cells through EphA3 cross-linking, direct killing of leukemic stem cells, tumor cell killing via potent ADCC activity, and blood vessel disruption due to tumor endothelial cell shape change.
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text: The nearby mountain areas of Melchsee-Frutt, Meiringen-Hasliberg and Engelberg offer everything hikers, bikers, mountain-bikers, fishermen and mountain climbers could wish for. The village itself offers several pleasant restaurant and hotels, as well as camp grounds and modern holiday apartments. Meet the locals at the small lakeside beach. Because of Flüeli-Ranft's central location, there are many excursion possibilities.


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o Semex's highest PTAM Baxter son with 95 lbs combined fat and protein
o Over 2.00 PTAT with great breakdowns
Genomax™ sires are the youngest and brightest sires available globally. Semex's rigorous genomic young sire standards ensure that these bulls are the very best young bulls in the world, with only one in seven bulls entering the Semex stud reaching Genomax status. Evidence of this is their consistent, high rankings in multiple systems worldwide. Semex's Genomax line-up is the envy of the industry and includes young bulls that are quickly becoming household names including: 0200HO07450 Amighetti Numero Uno and 0200JE00362 Gabys Arrow. New to this line-up in December are (complete listing at www.semex.com):
• 0200HO03823 GILLETTE JESSIC (Windbrook x Goldwyn)
• 0200HO06480 VAL-BISSON DOORMAN (Bookem x Shottle)
• 0200HO06366 GEN-I-BEQ P DELL (Brawler x Goldwyn)
• 0200HO06480 VAL-BISSON DOORMAN (Bookem x Shottle)
• 0200HO03809 VELTHUIS LET IT SNOW (Snowman x Planet)
• 0200HO09904 HOLBRIC-ML LIMOCAR (Man-O-Man x Shottle)
• 0200HO06450 LUCK-E ADONIS-RED (Larson *RC x Advent-Red)
• 0200JE00205 ALL LYNNS VAPOUR-P (Eclipes-P x Paramount)
• 0200JE00207 ALL LYNNS VINNIE ET (Region x Paramount)
• 0200JE09833 BLUE MIST MORALE (Vance x Jimmie)
• 0200JE00507 TOWER VUE KOOP (Tequila x Connection)
• 0200JE00521 WILSONVIEW SOPRANO (Zuma x Dale)
For more information on Semex, Genetics for Life, Repromax, HealthSmart or Genomax sires visit www.semex.com


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Top Definition
Acronym for Kraft Dinner, the Canadian version of Kraft Macaroni and Cheese. It's called KD in Canada, because Canadians consider this to be an entire dinner. Whereas in America, we consider it a side dish.
Canadian child: "Mom, how aboot you put down the bottle and make me some KD? I want to play hockey before the ice melts."
av Hayw00d 15 februari 2005
Trending Now
Can you define these popular missing words?
your kill to death ratio in cod
Jim: Dude, I'm a beast at cod.
Fred: What's your kd.
Jim: 2.57
Fred: Dude!
Fred: What's your kd.
Jim: 2.57
Fred: Dude!
av Air Jewish 14 november 2010
The act of just writing k in a text/im. People generally don't like responding to such a small answer thus being k'd generally ends the conversation. If you are the one being k'd, you should assume the person that k'd you is either very mad at you, or very pissy.
1: Hey, are you ok? You seem upset.
2: I don't wanna talk about it.
1: Well I'm here if you do
2: k.
1: *thinks to them self* Wow, I can't believe he just k'd me! I'm not answering that!
2: I don't wanna talk about it.
1: Well I'm here if you do
2: k.
1: *thinks to them self* Wow, I can't believe he just k'd me! I'm not answering that!
av footnote58 17 oktober 2010
Used in place of the term "cached" when a marijuana bowl is depleted.
This bowl is K'd man.
av Brian Hindt 4 oktober 2005
Kraft Dinner. A cheesy noodle food made by Kraft.
Cook? Well i can make KD...
av Freezy 5 september 2003
Hacked - software or hardware with their protection systems or mechanisms removed (or overridden), which yield open environments with little or no restrictions applied to them.
I K'd my modem.
av jrodsta 19 april 2010
A punch so strong that the people standing next to them get knocked out as well
The lil man threw a K-D and a whole bunch of people got knocked the F**K out!
av kudos 85 8 oktober 2007


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Follow HitFix Follow @hitfix
'Star Trek' legend William Shatner to attend USS Enterprise retirement event
Ship was the world's first-nuclear powered aircraft carrier
NORFOLK, Va. (AP) — Captain James T. Kirk will be on hand when the aircraft carrier USS Enterprise is officially retired.
A publicist for William Shatner tells the Daily Press that the actor will attend the ship's inactivation ceremony Saturday at Naval Station Norfolk. Shatner is scheduled to perform Friday in Newport News.
Shatner played Kirk at the helm of the starship Enterprise in the "Star Trek" television series and several movies.
The world's first-nuclear powered aircraft carrier returned to Norfolk from its final deployment earlier this month. Saturday's inactivation will be its last public ceremony.
Copyright (2012) Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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Summer's coming: A look ahead to 2013
It may not feel like it with the recent cold weather, but the 2013 county season is now less than seven weeks away.
Here are a few things that ecb.co.uk will be looking out for when things get under way on April 10.
Mahmood and Plunkett's time to strike back?
It is not so long ago that Sajid Mahmood and Liam Plunkett were viewed as the future of England's bowling attack.
Unfortunately things have since gone awry for the two pace bowlers, but they have the opportunity to make the most of a fresh start this year.
Having been released by Lancashire, Mahmood is ready to relaunch his career with Essex.
Plunkett, meanwhile, has made the switch from Durham to Yorkshire and will also aim to rediscover his best form in new surroundings.
Both men are blessed with an abundance of talent and should certainly not be written off. Their best days may yet lie ahead.
Who will be the next surprise package?
It is never easy to estimate who will fare well in any given campaign.
Yet 2012 seemed to throw up more shocks than usual.
Few will have tipped Derbyshire to claim the LV= County Championship Division Two title, while the likes of Nick Compton and Keith Barker were among numerous individuals to exceed pre-season expectations.
There is bound to be another surprise or two this summer, but can you foresee who will enhance their reputation?
If last year's office prediction table is anything to go by, the ECB's website team certainly cannot...
A rejuvenated Hamilton-Brown
Last June the sporting world was rocked by the tragic death of Surrey batsman Tom Maynard.
After a period of compassionate leave, Rory Hamilton-Brown, Maynard's closest friend, decided he could not continue his career at the Kia Oval and subsequently agreed a return to former club Sussex.
Speaking to ecb.co.uk following his move, Hamilton-Brown acknowledged the importance of having a fresh goal to focus on.
The all-rounder's priorities in life may now have changed, but do not be surprised to see him excel on his return to regular action.
Another year of brilliance from Trescothick
An ankle injury kept Marcus Trescothick on the sidelines for much of 2012 and prevented Somerset's skipper from registering his usual bounty of runs.
The powerful opener had comfortably surpassed the 1,000-run mark in first-class cricket for five successive seasons prior to last term.
Should he remain fit this summer, it is hard to envisage anything other than a sparkling return to form.
Expect centuries aplenty once again from the affable 37-year-old, who is determined to play on into his forties.
Improved weather!
Rain is an unfortunate staple of any British summer, but the disruption to the 2012 county season really took the biscuit.
Thousands of overs were lost to inclement weather, with entire four-day fixtures washed out in certain instances.
Surely, when it comes to precipitation, things can only get better?!


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Holiday Charm Bouquet
There's a whole lot of holiday spirit in our charming bouquet! We've gathered crisp white roses with bright red hypericum berries, creating a delightful gift for the most magical time of year. Add a delicious box of Harry London chocolates for an extra sweet surprise.
Add to their gift:


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About three weeks ago, I had the opportunity to go on an enjoyable ride. No, it wasn't a roller coaster at Cedar Point. I don't like those things.
This ride was on a modern tractor pulling a new state-of-the-art 24-row corn planter.
I suppose some folks would consider that a dull, uninteresting ride, but to me, it was fascinating to see the latest agricultural technology in operation. It made me think of all the changes that have taken place over the years.
My friend who bought this planter called one Saturday afternoon and asked me if I wanted to go for the ride and see this planter operate. It covers 24 rows on each trip across the field and can plant a lot of corn in a day. It has a GPS system and many automatic features. It is also a "no-till" planter, which means he can go into a field and plant with very little tillage of that field.
During the following week, I had an occasion to visit Amish friends over in Mesopotamia. While there, I noticed an older, two-row planter used on that farm. These two-row planters are still used on some smaller non-Amish farms and illustrate the changes that have taken place over the years.
To go even further back, I took another look at the old-fashioned "corn stabber" hanging in my basement. This would have been one of the earlier partly mechanized planters used to save labor and speed up planting 100 years ago or more.
Some of you may know what a corn stabber is or used one a long time ago. When I had a larger garden years ago, I used this one because it was easier than digging a hole and dropping in three or four seeds and covering them.
My corn stabber is essentially a 3-foot-long board with a handle at the top. On the bottom was a flexible, sharp steel point attached to a spring loaded arm that made contact with the ground. On the side was a metal box with a simple seed plate that would allow the correct number of seeds to drop when the arm was made to touch the ground.
To plant, one would "stab" the metal point into the ground and push the handle to the side to turn the seed plate to drop the correct number of seeds into the hole made by the point. Simple and easy. It was an improvement when it was invented, but a long ways from the 24-row planter that I rode.
So many changes have been made in the last 50 to 75 years ago that I find it hard to keep up with them. When I think about growing up in North Bloomfield and all the changes that have taken place in that village, it is remarkable. Like many villages, at one time there was a post office, two churches, hotel, livery stable, bank, hardware store, two general stores, taverns and more.
Now there is just one grocery store, the post office, still two churches, a tavern and a used car lot. Even the bank has closed, an institution that had been an important part of the community for a long time.
When I was growing up, a trip to Warren was quite an adventure. Going down Route 45 into Bristolville, one would find a cement road lined with maple trees on both sides. Cement roads were not always the smoothest, with bumps at each joint, but much better than gravel or dirt.
When the road was widened and improved, the trees had to give way to a safer, better road. It was sad to see them go but necessary.
So maybe a ride on a new 24-row corn planter might not be exciting to you, but it does reflect the changes and improvements that have been made in so many ways in our society. Or maybe you would like to borrow my corn stabber to plant your crop?
Parker is retired from Ohio State University and is an independent writer for the Tribune.


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Top Definition
The face you make when in contact with a female, also known as "the rapist face". It is when your mouth is half open and eyes are half closed while head bobbing. It must look creepy.
While sitting with his arm around Emma, Arie's face looked like The C-Vid.
بواسطة Biker12 إبريل/نَيْسان 30, 2011
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Angela Bertugli, of Rices Landing, and Gabriel Spece, of Thompsontown, were married on Aug. 10, 2012, at St. Hugh Roman Catholic Church in Carmichaels.
The bride is the daughter of Emilia Bertugli and the late Remo Bertugli, of Rices Landing. The groom is the son of William Spece, of Thompsontown, and Judith Spece-Wright, of Mifflintown.
Deborah West, of Wysox, sister of the bride, was matron of honor.
Article Photos
Mr. and Mrs. Gabriel Spece
The best man was Nicholas Spece ,of Thompsontown, brother of the groom.
Bridesmaids were: Brittany Bloam, of St. Marys; Ashley Sheaffer, of Brockway; and Madeline Snyder, of Jefferson, cousin of the bride.
The flower girl was Katherine West, of Wysox, niece of the bride and groom.
Groomsmen were: Jay Varner, of Batesville, Va.; Lucas Sheaffer, of Richfield, cousin of the groom; and John Esh, of Mifflintown.
Father John Bauer performed the ceremony that also included vocalist Erika Musselman, of McAlisterville.
A reception followed at the Hilton Garden Inn Southpointe, Canonsburg.
The bride is a 2001 graduate of Jefferson Morgan Junior-Senior High School; a 2005 graduate of Washington and Jefferson College; a 2007 graduate of University of Pittsburgh's Graduate School of Public and International Affairs; and a 2011 graduate of Widener University School of Law. She is employed as a research associate at the Pennsylvania House of Representatives.
The groom is a 1999 graduate of Juniata High School and a 2003 graduate of Susquehanna University. He is employed as an executive director at the Pennsylvania House of Representatives.
Following a wedding trip to Walt Disney World in Orlando, Fla., they reside in Lemoyne.


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Even in prehistoric times people wandered through the Lötschental and across the pass of the same name - as attested to by finds from the Bronze Age and the Ice Age. Up until the Middle Ages the Lötsch Pass was an important connection between the Bernese Oberland and Valais.
Even today the Lötschental is the starting point for innumerable mountain tours in a pristine landscape. Two hundred kilometers of hiking trails lead through the valley, which is part of the UNESCO World Heritage Region Swiss Alps Jungfrau-Aletsch. Old customs such as the well-known shrovetide tradition "Tschäggätä" have been preserved here. The Lötschental skiing region is located at the Lauchern Alp above Wiler, where a mountain train takes visitors high up to the glacier skiing region.
During summer, hikers abound in the Lötschen Valley, an ideal region for those seeking relaxation and natural beauty. The walk from the Lauchernalp across the Lötschenpass into the Bernese Oberland to Kandersteg ranks among the classics of the region. Fafleralp, situated right at the rear of the Lötschental is the starting point of the Lötschental 'high route' across south-facing Alpine pastureland through to the Lauchernalp.
In winter, the snow-guaranteed, well-developed winter paradise Lauchernalp invites you to linger. The sunny ski resort offers you 55 km slopes up to 3111 m above sea level, and opens up a racy freeride area. Surrounded by the imposing mountain backdrop of the UNESCO World Heritage Site, lies the well with a cable car, two chair lifts, two t-bar-lifts and a glacier cableway accessible skiing area Lauchernalp. The glacier cableway leads up onto the Hockenhorngrat (3111 m, glacier ski area with numerous medium-difficulty pistes and freeride arena), and also provides access to a winter walking trail at over 3000 metres in altitude with a panoramic view of 40 four-thousand-metre mountain summits.
For cross-country skiers and winter hikers there are about 50 km winter hiking trails, as well as 24 km classic and skating trails to explore.
- Mask carving course – learn traditional mask carving under the expert guidance of traditional mask carvers.
- Lötschental Legend Trail – visitors of all age groups on the tracks of Lötschental's legends, myths and fairy tales.
- Hockenhorn – one of the highest mountain summits in Switzerland able to be traversed by hikers (3293 m).
- World Heritage Swiss Alps Jungfrau-Aletsch – listed as a UNESCO World Heritage site since 2001.
- Ferden, Kippel, Wiler and Blatten – Lötschental villages with practically untouched, historic village centres.
Top Events
- «Tschäggätä» – a wild Lötschental carnival tradition (start of February to Ash Wednesday).
- Corpus Christi procession – a religious procession with the colourful «Herrgottsgrenadieren» (Grenadiers of Our Lord) (end of May/start of June).


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Systemwide Events Calendar
Thinking about Law School?August 28, 2013 - April 22, 2013
Manoa Campus, Campus Center, 2nd Floor
Check out the William S. Richardson School of Law table at Campus Center. Visit with a representative from the law school. Pick-up a brochure and learn about FREE pre-law resources available to the public on the UH Mānoa Campus.
Event Sponsor
William S. Richardson School of Law & Manoa Pre-Law Advising Center, Manoa Campus
More Information
Elisabeth Steele Hutchison, (808) 956-5557, email@example.com, https://www.law.hawaii.edu/admissions
|Wednesday, August 28
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Coffee Talk
Hawaii Campus, Manono 379-15 / UH Hilo 324, 346
|First Aid/CPR/AED Training Class - CLASS FULL
Manoa Campus, Campus Center Executive Dining Room
|Welcome Back Club Rush Celebration
West Oahu Campus, Campus Courtyard
|Centers of Biomedical Research Excellence (COBRE) Research Seminar Series
John A Burns School of Medicine, Kakaako Campus, 651 Ilalo St, Med Educ Bldg, Room 304
|Pacific Connections: New Caledonia, Kanaky or Kanaky-New Caledonia?
Manoa Campus, EWC Burns Hall room 3012
|Philosophy Final Oral
Manoa Campus, Sakamaki D-302
|International Language Exchange
Manoa Campus, 7/24-Hemenway208, 7/31-Campus Center310, 8/7-HEM211, 8/14-HEM204, 8/21-HEM201, 8/28, 9/4 &11-CC310
|ASUH General Senate Meeting
Manoa Campus, Campus Center 310
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- Arts Exhibition: Peranakan Chinese Heritage of Southeast Asia
- The Wonder of Learning: the Hundred Languages of Children Exhibit
- Waikiki Parc Features Nicole Naone
- Course Reserves Deadlines and Information
- Welcome Week
- Welcome Week
- Open At-Large Student Senator Seat
- Thinking Design: Creating Memorable Images with Duane Preble and Philippe Gross
- Thinking about Law School?
- 50 Years After the March on Washington for Jobs & Freedom: Human Rights in U.S.
- Diversity and Equity Initiatives Fall 2013
- Understanding Plagiarism with Some Help From Dr. Seuss


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Are you a facility manager, building engineer, or health and safety officer who wants to improve the indoor air quality of your building? Are you properly prepared to handle air quality complaints? Common mistakes can turn a small grievance into a wildfire of speculation and accusation.
In this Certified Indoor Air Quality Manager Online Training and Certification Program, you'll learn how to diagnose, resolve, and prevent indoor air quality (IAQ) complaints. You'll also establish a comprehensive IAQ plan specific to your buildings.
Upon successful completion of this program, you'll be able to:


text:
Top Definition
extremely ugly woman resembling something that lives in a swamp
that girl you were with last night was a bog beast
โดย spook 15 เมษายน 2004
Trending Now
Can you define these popular missing words?
A really ugly girl or woman usually a bit rough or scary looking with bad or disgusting habits. i.e. fanny scratching public farting bogie flicking etc.
The bogbeast put me off my food with her boot ugly boat race (face) and the continual scratch and sniffing of her own rank muff.
โดย Bogbeast 29 สิงหาคม 2011


text:
Return to Top
Mailing Address:
Welcome to Finance and Administration!
Student Services
If you need Financial Aid assistance, go to the Financial Aid Office website or call 254-968-9070.
Faculty & Staff Services
Mission and Values
The Division of Finance and Administration is committed to ensuring the success of Tarleton State University. We support the University Vision of being 'The Premier Student Focused University in Texas' through our mission of Service, Safety and Stewardship.
Our Division Values
- Professional (which includes the core values of the university)
- Cost Effective
- Proactive
- Collaborative
- Transparent
Let us know how we can serve you better!
Contact Info
Vice President of Finance & Administration
Phone: (254) 968-9877
Fax: (254) 968-9438
Administration Building
Room 227
Mailing Address:
Box T-0110
Stephenville, TX 76402


text:
Join or Sign In
We search the globe for instructors who really get it and understand the delicate art of instruction. All of our instructors share a love of craft and a deep appreciation for the creative process.
Learn from our world class instructors!
Take Craftsy with you!
Craftsy Apps for iOS and Android. Read more »


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Top Definition
A full body cast that is worn for a lifetime. Used in the event of a terrible accident or the lack thereof a skeletal structure.
Our uncle was in a clast after the motorcycle accident. Thanks to the clast, he lived a productive life.
โดย Sandy 20 ธันวาคม 2004
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text:
PITTSBURGH - Four Pittsburgh Pirates players will be on the National League all-star team.
It's interesting that the list doesn't even include the one who was the team's Most Valuable Player in the first half of the season.
Russell Martin doesn't have the big stats that will get an All-Star berth, but his impact on the Pirates has been significant.
His ability to throw out base stealers has dented opponents' ability to run against the Pirates. Martin has delivered timely hits, and he's deftly handled the surprising pitching staff. The pitching has been better, and the first-string catcher has something to do with that.
Like all the other Pirates players, Martin is challenged to play at the same level in the second half of the season.
What he's done through the first half sets an exceptionally high standard.
Meanwhile, the Pirates are well past the point where they have token representation at the All-Star game. They're sending four players, two of whom were drafted and developed by the Pirates (Andrew McCutchen and Pedro Alvarez), and two who were acquired from other organizations at low cost (Jason Grilli and Jeff Locke).
As manager Clint Hurdle said, "Two years ago, Grilli was pitching in Scranton."
SUBHEAD: Making the cap fit
Ray Shero's busy offseason took an unexpected turn when the Penguins' GM was able to bring back Rob Scuderi as a free agent.
Scuderi is the kind of tough and responsible stay-at-home defenseman who can help win championships. After he won the Stanley Cup with the Penguins in 2009, he took an offer from Los Angeles that the Penguins had no hope of matching.
Scuderi's signing means the Penguins will probably trade a defenseman before the season. Most signs point to Matt Niskanen leaving, but would the Penguins consider moving Brooks Orpik, who would be more likely to bring back the kind of young forward the Penguins need?
Orpik is 32 and approaching the last year on his current contract. Given their cap issues, it's questionable whether the Penguins will keep Orpik beyond the upcoming season.
It might be time to consider dealing him.
SUBHEAD: Out of focus
Classic moment during Friday afternoon's Root Sports Pirates broadcast: Robby Incmikoski's in-game interview with Clint Hurdle's father was cut short when a Wrigley Field usher supervisor scolded them for blocking the view of fans.
Announcer Greg Brown seemed to be upset by the lack of hospitality, but it was actually another lapse in judgment by Root. The interview would have fit well on the pre-game show or on Root's "Inside Pirates Baseball," which could always use a new idea (Putting a microphone on a player has gotten terribly stale).
It was the fifth inning of a competitive (4-2) game. There was no real reason to turn away from the field to have the manager's father praise his son.
This came a day after someone thought it was important to have Incmikoski ask a PNC Park fan about his little girl's fondness for cotton candy.
The people who bought tickets at Wrigley just wanted to see the game. So did the viewers at home, but they can only yell at the screen.
Mehno can be reached at firstname.lastname@example.com


text:
Top Definition
gentelman, erotic, sexual, non-gay, man whore,gets all the woman, men dislike him for his romanticness with the woman
damn florentino gots game!!
от juan mode 21 юни 2011
Trending Now
Can you define these popular missing words?
A closeted gay, dirty, smelly unemployed man that lives with his mother. Would rather collect welfare then be a man and work, Usually lacking in the genital area.
Man, get a J.O.B., you don't want to turn into a Florentino.
от Krestena 28 август 2010
a really gay nerdy peson who loves cars more than women
Your such a florentino
от faustino 10 ноември 2008


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According to most versions of history, America's founders were united in their moderate political philosophy. But in fact the Revolution was nearly derailed by extremists who wanted to transform the entire society. If not for a small circle of conservatives who kept radicalism in check and promoted capitalism, a strong military, and the preservation of tradition, our country would be vastly different today.
In the first book to chronicle the critical role these men played in securing our freedom, David Lefer provides an insightful and gripping account of the birth of American conservatism and its effect on the earliest days of our nation.


text:
Top Definition
A commonly used technique in both film and television to shift focus from a foreground object to a background object by turning the the focal ring on a lens.
Examples of rack focus can be seen in almost any movie or tv show when the focus is shifted from one object--mostly people--to another. It is most often used dramatically.
rack_focus tərəfindən 22 Fevral 2006
Trending Now
Can you define these popular missing words?
When a director forgets what he is shooting and films breasts up close.
"The movie is still in editing becuase the second scene was rack focused."
AllChiggedOut tərəfindən 08 Mart 2007
When a cinematographer turns the focal ring on his lens to shift focus from a foreground object to a background object.
A rack focus is really a cheap, metaphorical device for the unimaginative to link two objects/people in a frame.
creedmoor tərəfindən 20 Noyabr 2004


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- Details
NEC Arc Flash Protection Labels - Danger Arc Flash Hazard Appropriate PPE Required
- Arc flash hazard warning decals are required by the National Electric Code (Article 110.16) to help reduce the occurrences of serious injury or death due to arcing faults to those who work on or near energized electrical equipment
- Available in self-adhesive vinyl and vinyl with Ultra-Stick
- Self-adhesive vinyl option ideal for clean and regular surfaces
- Ultra-Stick option permanently bonds to irregularly textured surfaces even in the presence of dirt and grease
- Choose from 2 sizes
- Label reads "Arc Flash Hazard Appropriate PPE Required"
SpecificationsSelect options above to see specifications.
- Help
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We have experts on staff to answer all your questions Monday-Friday, 7:30am to 7:00pm EST


text:
Jan. 8, 2013
Baseball fans still have several weeks to wait before pitchers and catchers report for spring training, but there's plenty of baseball-related activity on tap for Wednesday.
Major League Baseball will announce the results of the annual Baseball Writers' Association of America Hall of Fame balloting at 2 p.m. EST Wednesday. The announcement will be broadcast live on the MLB Network and simulcast live on MLB.com and baseballhall.org.
About 600 baseball writers voted on 37 players this year, with some names that would have been considered first-ballot "sure things" for the Hall during their careers now considered the longest of first-ballot longshots.
Those tainted longshots include Barry Bonds, Sammy Sosa and Roger Clemens, all names now associated with the legacy of illegal performance-enhancing drugs and the "Steroid Era." Rafael Palmeiro and Mark McGwire are in their third and seventh years of eligibility respectively, and their chances aren't much better than those of Bonds and company.
However deserving these players may or may not be when all is said and done, don't expect them to be among the 2013 inductees.
One player who absolutely deserves to be enshrined into the Hall of Fame this year, though, is longtime Houston Astros second baseman Craig Biggio.
As a Cardinal fan, I remember hoping that Biggio would not get a chance to hit in clutch situations against the Redbirds. The thought of Biggio at the plate with the game on the line was not a pretty one. Statistics show Cardinal fans had good reason to be nervous with Biggio batting: In his 20 years with the Astros, Biggio racked up 280 hits and 131 RBIs against the Cardinals, his best totals against any team in those categories.
The numbers don't tell the whole story of this remarkably consistent and hard-working infielder. Biggio, more than any of his talented Houston teammates over the 20 years he played, was the consummate "tough out," and that held true from his first game in 1988 to his last game in 2007.
His numbers, however, do tell a powerful story. He had 3,060 career base hits, one of only 28 players to have achieved that coveted milestone. He swatted 291 home runs and 668 doubles (fifth on the all-time list), with 55 triples and 414 stolen bases for good measure. Biggio, who passed up a chance at high-dollar free agency to remain with the Astros after the 1995 season, played all of his 2,850 games with Houston.
Regardless of who else makes the Hall of Fame this year, Biggio ought to be standing tall when the induction ceremony rolls around this summer in Cooperstown.
Sources and Resources:
Additional sources and resources linked to in text.


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Serves 12 |
Prep Time 2 hours 5 minutes |
Cook Time 0 minutes
1 quart Eden Apple Juice, 32 oz.
1 quart Eden Cherry Juice, 32 oz.
Freeze Pop Containers, Or Small Cups And Popsicle Sticks
Mix the juices together and pour into freeze pop molds. Freeze 2 hours or until solid.
If using small cups and popsicle sticks, partially freeze the juice in the cups, and insert the sticks when about half frozen so that they stand up straight. Continue to freeze until solid.
American, Dessert & Pastry, Fruit, Gluten-Free, Low Sodium, Macrobiotic, Vegan, Wheat-Free


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Windows Phone Minute- Rocking the Lock Screen
- Posted: May 14, 2012 at 8:32AM
- 7 comments
Loading user information from Channel 9
Something went wrong getting user information from Channel 9
Loading user information from MSDN
Something went wrong getting user information from MSDN
Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
Take a minute out of your day to learn about all the killer new features on your Windows Phone. Trust me, you'll be glad you did
Oops, something didn't work.
Are you able to double tap the Windows Button are you able to show/hide the playback controls?
But not in Poland
Chris, No. You access the controls by simply hitting one of the volume buttons on the side.
@jjbowles:OK, seems simple enough, does WP7 support control talk? the play/pause and volume rocker on the cord?
Wow, that was... disappointing .
How about a video about how to remove the playback buttons again, once you are done playing music?
@MrAndersen: there's an app for that!
Unfortunately, the lock screen fades to black very quickly (even when the phone is plugged in, and the timeout is unrelated to the user-adjustable "Screen times out after" setting), so you don't get to see this "rockin'" screen for long...
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


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Watching as the Air Evac medical helicopter lands - and capturing it on some of their cell phones - are (from left) Beaver Local varsity cheerleaders Rachel Smith, Ciarra Fair and Taylor Fisher and (right) varsity volleyball player Tannar Dolhun. They participated in Saturday's Safety Day at the Calcutta Kmart that also included Glenmoor and Calcutta fire departments and Lifeteam ambulance. More photos are found on Page 9A.
Article Photos
Morning Journal/Jo Ann Bobby-Gilbert


text: And in the middle of it all stands a mighty rock that has braved the elements for thousands of years. A cruise of the Rhine Falls lets you reach the rock, where you can experience the nature spectacle up close. Also the platforms that partially jut out into the Rhine, enable you to stand almost in


text: Secrets of the Oracle (5) tv-pg Play video Select your TV provider to log in to have full access to videos Select your TV provider See all providers Don't see your TV provider? Learn more You can access this video on the free HISTORY® app. *You must verify your TV provider towatch this video on the App Your Parental Control settings do not allow you to view this content. Secrets of the Oracle (5 min) tv-pg Scientist use geology to explain powers of the Oracle at Delphi.


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Top Definition
a sexual act in which fried chicken is eaten while sticking out of a person's anus (as in, you need a bucket of chicken to perform it). Originated in Baltimore, Maryland.
Hey baby, how about goin' to Popeyes so you can give me a bucket job later?
BaltimoresFinest가 작성 2007년 04월 19일 (목)
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In the six weeks since a gunman killed 20 students and six adults at a Newtown, Conn., elementary school, Greeley-Evans School District 6 officials have taken a look at their own policies and procedures and tweaked them to make Greeley's schools safer.
John Gates, director of safety and security for the district, updated the board of education on Monday about additions he believes will keep students out of harm's way.
"We are fully committed to helping ensure the safety of every student, employee and visitor within our schools," Gates told the board. "This is a critical priority and must be a collective effort. It will require that the school district, policy-makers and communities work together."
Gates discussed the district's current efforts and protocols and identified areas that he believed needed more attention. He also outlined the changes that will take place over the next few weeks to months.
Last week, Steve Reams, bureau chief for the Weld County Sheriff's Office, who is also a member on the Valley Re-1 School District Board of Education, spoke to board members about school safety at an all-day retreat. He said the district's relationship with local law enforcement is a model many districts wish they could replicate.
"(Greeley Police Department) presence is something I'm envious of as a school board member, myself," Reams said. "You have a great relationship with your law enforcement. That relationship also exists between the sheriff's office and the GPD and the (Evans Police Department) so that you can interchange us at anytime."
On Monday, Gates discussed the current formula for safety and drills in the district. In addition, he said one full-time school resource officer — who is an on-duty, armed Greeley police officer — is located at every traditional high school, and two more float among the four middle schools.
The officers are paid for by the city at a cost of more than $400,000 per year, something board members applauded as a commitment the city has made to keep schools safe.
"This is a very conscientious police department," said board member Paleri Mann. "You are very sensitive to student needs. It is instant and on the spot that you are making sure things fit for the day. You always have something in place to take care of our kids."
The district also employs three unarmed security guards at each high school (two at Jefferson High School) and one at each middle school and conducts regular fire, tornado and lockdown drills.
"Performance in a drill is a sole indicator of expected performance in an actual emergency," Gates said. "If we don't practice and master drills, we simply are not creating the most safe environment."
All volunteers in the schools must pass background checks. To date, 14 people have been rejected for safety concerns. Likewise administrators have threat assessments they follow to investigate threats against the schools. Last year, the district investigated 70 school threats that were handled without incident.
Greeley police Chief Jerry Garner told the board that Gates' experience as a law enforcement officer is an asset they can't afford to lose.
"In the 43 years I've been in law enforcement and seeing the relationships in a number of school districts, you have a treasure in John Gates," Garner said. "The police officers know and trust Mr. Gates. He is an asset to you and he is credible to us. That relationship has been the best defense in keeping your schools safe."
Changes Gates outlined that will take place over the next few weeks to months included additional unarmed guards who will man the main entrances and check visitors at the middle and high schools. All 14 elementary schools will get electronic locks on the main doors, requiring visitors to be buzzed in. All high school students and staff will be required to wear identification badges that are visible at all times. And Gates will form a safety task force that will meet at least quarterly to review policies.
Long-term plans include two additional SROs so each middle school has a full-time armed police officer.
"Schools remain safe places," Gates said. "They are in fact safer than they were 20 years ago. That being said, school safety is a continual work in progress that must remain a priority each and every day by all stakeholders."


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Top Definition
A pretty girl with low confidence at times, but has a great personality and a pretty smile. She's kind of like the Disney princess Tiana in The Princess and the Frog. She has a lot of friends and doesn't always deserve the things that happen in her life.
That Denajah is really cute! No wonder Mark loves her!
bestlover6969dude tarafından 30 Temmuz 2012, Pazartesi
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Systemwide Events Calendar
Career Matchmaking OPEN HOUSEMay 18, 10:00am - 3:00pm
Windward Campus, Kuhina 106
In just two hours learn about your possible career choices with our Career Matchmaking open house.
- Discover your career matches
- Search for jobs and learn about their requirements
- Find the UH Community College for the training you will need
For more information call 235-7386
May 7th and 18th in Hale Kuhina 114
Event Sponsor
Career and Community Education, Windward Campus
More Information
Career and Community Education, 808-235-7386, firstname.lastname@example.com
|Saturday, May 18
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Free Commuter Cycling 101 Workshop
Whole Foods Market Kailua
|Career Matchmaking OPEN HOUSE
Windward Campus, Kuhina 106
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.


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Journalist Fox 2 News
By Kellie Walker
When it is all said and done, Al Allen will be regarded as a genuine voice of the community who tells a story without compromise and asks the questions that people in the community want answered. Fueled by his passion to be active in the world of broadcast journalism, Allen, in the 60s, began establishing his career and working toward building a foundation of success.
With a strong belief that education is where his foundation would begin, Allen studied at the Detroit College of Business and received an associate degree in business administration; he went on to study journalism at the University of Arkansas at Pine Bluff, where he received a bachelor's degree. He began his broadcasting career as a news director at KOKY radio in Little Rock, Arkansas. Ultimately, he moved backed to Detroit where he worked as a reporter and news director at WCXI-AM and WGPR-FM, and as news and public affairs director at WJLB-FM. In March of 1984, Allen began reporting for WJBK Fox 2 News and even after 28 years of service, he is still motivated by reporting breaking news stories. He says, "The adrenaline is still flowing."
Allen is consistent in taking a genuine approach in all that he does which has had significant impact on who he is as a reporter. He has seen the scope of media change over the course of his career; however, he has exhibited an unwavering devotion to sincerely reporting stories that are meaningful, informative and useful in guiding the Detroit community in the right direction. He prides himself with being able to use limited information to pull together a story that is relatable, interesting and news worthy. Allen explains, "You control the story, don't let the story control you."
Allen has diligently worked to build credibility as a journalist; he makes it a priority to be visible in the community by fulfilling requests to speak at engagements, being in attendance at community events, and making himself available for the people in Metro Detroit. "I am lucky to have been able to remain and work in the same community for all these years. With broadcast journalism, you become a member of the families of the people in the community and I thank God that I have been able to do this job and do it well," says Allen.
He has received recognition on both local and national levels for his work and dedication to the industry, which includes awards from United Press International, the Associated Press and the National Association of Black Journalists. He also received the Robert F. Kennedy Journalism Award for his work on a documentary that examines the issues surrounding black-on-black crime in Detroit. Crime by Color, Black on Black investigated issues that influence an increase in crime rates in the black community inclusive of alcoholism, economic hardship, the lack of social education, the disparity between job availability for blacks versus other groups, and general trials and tribulations experienced by people of color.
Like most people, Allen does experience a minimal amount of regret about some decisions he's made, namely, turning down a position with NBC that would have provided him national exposure or possibly led to him becoming a network correspondent; but make no mistake, he is completely satisfied in knowing that his work with Fox 2 News has resulted in developed abilities and strong character. Journalism has been Allen's beginning, middle and will undoubtedly be his end. Allen uses the words of a colleague as incentive to continue reporting, "Your only as good as your last newscast and your last newscast wasn't that good!"
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The college has nine, 12-passenger travel vans divided equally into 3 main groups; Academic, Athletic, and Student Activities. These departments have priority over the vans assigned to them up to 14 days before departure. No priorities will apply to requests made less than two weeks prior to the proposed trip. If vehicles are available, they will be reserved on a first-come, first-served basis. No person, who has reserved a vehicle and been acknowledged, will be "bumped" or deprived of that vehicle prior to the proposed trip, except in the event of mechanical difficulties that make the vehicle unavailable. All requests for vans shall be made on line through the Events Calendar.
Policies and Procedures
Select "Van Reservation" as your Event Type, and include an account number and the name of your authorized driver on the third screen.
Please review these policies if you are planning a trip in a College vehicle.
If you are interested in becoming a student driver, please consult these materials to see if you meet the qualifications for authorization.
Qualifications include:


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Sachajuan Conditioner Travel Size
Please select a color and size before adding to your cart.
Please select a color and size before adding to your Wish List.
Please select a color and size before adding to your Gift List.
Conditioner Travel Size
Select Returns & Free Shipping on All U.S. Orders. See Details
This product with Ocean Silk Technology provides superior conditioning and detangling. The formula makes hair supple and strong. It leaves hair with bounce and a silky shine.
100 ml
Founded in 2004 by hair industry pros Sacha Mitic and Juan Rosenlind, SACHAJUAN is a luxury haircare line self-named after the duo's cult-favorite Stockholm-based salon. From its minimal packaging to its high-grade natural ingredients, the Swedish brand prides itself on an easy and functional approach to personal grooming that's suitable for all hair types. Each shampoo, conditioner, and styling treatment contains the company's patented Ocean Silk Technology, a "broth" of effective nutrients and proteins extracted from cold water sea algae and infused with active ingredients to replenish, rebuild, and strengthen your mane.
Need Help? Have Questions? Contact Us.
Please call 1.888.222.7639 to speak with a Customer Service Representative.
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How old do I need to be to volunteer?
You need to be at least 15 years old.
How do I get a volunteer application?
Call our office and leave your name and address and phone number. Please speak slowly and clearly. We will send you an application in the mail, along with a list of our current openings. Or just fill out the application online. We will call you for an appointment.
Can we volunteer as a group?
Unfortunately, we do not have group opportunities.
How long do I have to commit to?
You will need to give at least 6 months, although we do accept semester commitments for students. Volunteers usually help one 4 hour shift per week.
I need to complete hours for a court-ordered community service, can you help?
We take very few court-ordered volunteers. Each volunteer must pass a Criminal Records check first.
Do you have opportunities on the weekend?
We frequently need weekend volunteers for the Coffee and Gift Shops.
Do you have programs for high school students?
Yes, we have a Summer Junior Volunteer program which welcomes high school students. Applications for the Summer Program are sent to Guidance Counselors at each school in April. Check with your school or call our office for a Summer Junior Volunteer Program Application
We also accept students for after school placement in some areas of the hospital. Internships for high school seniors are available on a limited basis.
I am a college student and am getting credit to volunteer or need an internship, whom do I contact?
Please contact Volunteer and Student Services at 413-582-2251 if you will receive credit for your volunteer time. This process requires a separate application and a contract with your school. Please apply at least 4 weeks in advance of your start date. Prior approval by the department manager is required in advance of submitting an application.
Cooley Dickinson Hospital • 30 Locust St. (Route 9), Northampton, Mass. • (413) 582-2000


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One of the things that I think sets New Yorkers most apart from people from many other parts of the country is our distinct appreciation for the concept of irony – whether its in our humor (it's no coincidence that the sitcom "Seinfeld" – perhaps the most ironic comedy ever produced on television – is set in New York City), or in recognition of the sometimes circuitous journey that life take us on, New Yorkers appreciate irony like almost no other people on Earth. Given this fact – and considering that I am a born & bred New Yorker – I have always found the events of Holy Week extraordinarily powerful. It is a week of events that to the common observer appears to begin with Earthly exaltation ending five days later in apparent weakness, humiliation and death…..and yet to believing eyes, these circumstances are quite the opposite – the events at the culmination of this most Holy of weeks signifying not the destruction of a particular life that those in authority in that time and place had intended – but instead, the beginning of life renewed for all of us; a sacrificial gift of love that created hope of life renewed for us all. It is for this reason that we Christians call the Friday of this week "Good" Friday – it is not because the things that happened to Jesus on that day were in any sense good: the conviction of an innocent man for reasons of politics and religious intolerance, His scourging and torture, and His eventual execution by the means employed by the governing authority of that day on a Cross, are by no means "good" things – neither today nor 2,000 years ago. No instead, we Christians call this day "Good Friday" because it was on this day that Jesus Christ took on the means employed by the governing civic and religious authorities of his day who intended to utterly humiliate, degrade and destroy him by those means, and yet – by the power of His loving sacrifice – He transformed these terrible events into the birth of hope for the world that has endured for the over 2,000 intervening years since that day when those in authority thought that they had finally "taken care" of what they considered to be their "Jesus problem".
This thought about the irony of the fact that we Christians dare call the day of Jesus' loving sacrifice "Good" Friday hit me recently when a colleague of mine – after I had returned from the Sirius/ XM studios with our Executive Director Msgr. Kevin Sullivan after the taping of one of his "JustLove" programs – asked me about the topics discussed on the air that day. I responded to her that that day, we had highlighted one of our "Catholic Charities Around the Nation" segments, and that the topic that we had discussed was a shelter – operated by Catholic Charities of the New Orleans Archdiocese – that assisted those who were victims of sexual assault and domestic violence to remove themselves from their abusive situations and begin to rebuild their lives in an atmosphere of support and respect. In response to my statement, my colleague challenged me how I could maintain a hopeful disposition when discussing a topic as horrible as sexual assault and abuse. To be honest, her question left me very shaken – and I truly had no adequate answer for her at that moment; she got me thinking not only about sexual assault and domestic violence, but about many of the topics that we had discussed during the show for the past several month – of the aftermath of the earthquakes in Haiti and Japan and the overwhelming toll of death and destruction that occurred in these places, of events like the Triangle Shirtwaist Fire whose 100th anniversary just occurred where many young working immigrant girls lost their lives due to a desire for profits over safety, of the tragedy of the shooting in Tucson in January that took the lives of 6 innocent people including a 10 year old girl born on September 11, 2001 – all these things terrible –and like those things done to Jesus that Friday 2,000 years ago – none of them in any way or any sense "good".
My colleague's question continued to haunt me for some time; like any good one, it had me search deeply within – asking fundamental questions about human suffering, about pain, about loss, about love, and about God. Blessedly, this searching on my part happened during the later stages of Lent and Holy Week, when our attention turns to Jesus' own suffering and death. Answers to these questions are of course never easy, even those who were closest to Jesus during His life on Earth remained confused when confronted with His profound suffering, of His undeserved death. In Scripture, after the events of Good Friday, the women who accompanied Jesus – Mary Magdalene, Joanna and Mary the mother of James, all while the male disciples were in hiding – went to Jesus' tomb to anoint His body with spices as was the Jewish burial custom of the day. I am sure that they were all three troubled by questions as they walked together to that tomb – questions about suffering, about pain, about loss, and about God – and they sought answers. When they had reached their destination, they found Jesus' tomb open and empty. In answer to their questions, a messenger from God appeared to the women and asked them "Why do you seek the living among the dead", informing them that Jesus was not there – and reminding them of Jesus' words to them that His suffering and death would not be final, but that He would be raised up. God's messenger did not then dismiss the women upon proclaiming Jesus' triumph over suffering and death, instead he called them to action – enjoining them to "go quickly and tell the disciples, "He has been raised from the dead, and He is going before you to Galilee"….for Jesus Himself at that time was not standing still but was on the move ahead of them…
Here at Catholic Charities of the Archdiocese of New York, our motto is "Providing Help. Creating Hope."; that motto is included in our logo, and appears in the shadow of a Cross. It is here, in reflecting on the words of this motto – in the shadow of the Cross, on this Easter weekend – that I believe I can begin to find an answer to my colleague's question. If we, like the first Christians – those women who witnessed both the terrible suffering and underserved death of Jesus as well as His Resurrection from the dead – can respond in action to the terrible suffering of this world, perhaps we can play a small part in creating the Hope that His loving sacrifice and Resurrection laid the foundation for on that first Easter weekend 2,000 years ago.
A Blessed Easter to you all!


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Top Definition
A person who has an irrational fear and hatred of iPhones, iPods and similar high-tech personal electronic devices.
He's such an iPhobe, he didn't even have a cell phone until 2009--and that's only because I gave it to him.
di GlenCallenderUFA 26 marzo 2009
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Someone who has an intense dislike of Apple, their products and their fan-boys/fan-girls.
Guy:I queued for 6 hours for the iPhone 5.
Other guy: OMG, you're such an Apple sheep!
Other guy: OMG, you're such an Apple sheep!
di tonyttt31 07 luglio 2014
To be afraid of the iAge and the associated iTechnologies. Basically to boycott all apple products and stick with the boring old microsoft world.
1. No its ok you can keep your new iphone, I want to stick with my Nokia 6610, its got all the latest features.
2. I cant believe you dont have an ipod, you're such an iphobe.
2. I cant believe you dont have an ipod, you're such an iphobe.
di HBJ 11 novembre 2007


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Young announces Washington Co. mobile office hours
UPDATED 2:25 PM EST Feb 26, 2013
Indiana residents who need help dealing with a federal agency such as the IRS or FEMAwill get their chance Wednesday,
The staff of Rep. Todd Young will be holding mobile office hours in Washington County.
The office will be set up in the council chambers at Salem City Hall from 8:30 a.m. to 4:30 p.m.
On Wednesday, caseworkers will be available to offer assistance for constituents who need help with applications or other issues.
The office hours are at the Salem City Hall Council Chambers at 201 E. Market St. in Salem, Ind.
Anyone with questions can contact the Jeffersonville Constituent Service Center at 812-288-3999.


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The Big Tiny Memoir: Dee Williams Shares Realities
Over the years, Dee Williams has acquired many fans. Tumbleweed Tiny House Company folks may try to push everyone aside and say "we are the MOST die-hard fans."
What really gets us going are the stories and insights Dee shares, because she has lived tiny for many years. If you are even thinking about going tiny, we hope you have already watched Dee or read about her. If not, then please visit Portland Alternative Dwellings and catch up.
Dee writes and publishes her story
Dee has written her story, The Big Tiny, which will be officially released by Penguin Press in April 2014. She shares all her clear-headed thinking, including her hopes and fears in abundance. Whether contending with the weather, her concerns about flames in the house or what grade-schoolers experience while stuffing into her house, there's a silver lining:
"I thought I'd find something in all of this, and I got more than I bargained for. I discovered a new way of looking at the sky, the winter rain, the neighbors, and myself; and a different way of spending my time. Most important, I stumbled into a new sort of "happiness," one that didn't hinge on always getting what I want but rather, on wanting what I have. It's the kind of happiness that isn't tied so tightly to being comfortable (or having money and property), but instead is linked to a deeper sense of satisfaction—to a sense of humility and gratitude, and a better understanding of who I am in my heart.
I know this sounds cheesy, and in fact, it sounds fairly similar to the gobbledygook that friends have thrown at me just after having their first baby. But the facts are the facts: I found a certain bigness in my little house—a sense of largeness, freedom, and happiness that comes when you see there's no place else you'd rather be."
Watch Dee in action
One of our favorite "day in the life" videos shows Dee Williams going about her daily business, from inside and outside her tiny house. It was filmed as part of a National Building Museum exhibition, and shows Dee living in her home built with Tumbleweed plans.
What's next for Dee
When a book gets published, the author typically travels cross-country to local book store events. Dee Williams may be showing up in your neck of the woods soon:
Washington, DC (4/22) - Brooklyn, NY, PowerHouse Arena (4/23) - St. Louis, MO, Left Bank Books (4/24) - Little Rock, AR, Arkansas Literary Festival (4/23-24) - Denver, CO, Tattered Cover (4/28) - Boulder, CO, Boulder Book Store (4/29) - Seattle, WA Third Place Books (5/1) - Portland, OR, Powell's Books (5/2) - Corte Madera, CA, Book Passage (5/4) - Santa Cruz, CA, Bookshop Santa Cruz (5/6) - Los Angeles, CA, Vroman's Bookstore (5/8) - Bellingham, WA, Village Books (5/11)
If you're luck to live near one of these appearances, then put it on your calendar. You will meet Dee, listen to excerpts, and likely mingle with other local tiny housers.


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The smash-hit musical AMERICAN IDIOT tells the story of three lifelong friends, forced to choose between their dreams and the safety of suburbia. Based on Green Day's GRAMMY® Award-winning multi platinum album and featuring the hits "Boulevard of Broken Dreams," "21 Guns," "Wake Me Up When September Ends," "Holiday" and the blockbuster title track, AMERICAN IDIOT boldly takes the American musical where it's never gone before.
With direction by Michael Mayer (Spring Awakening), choreography by Steven Hoggett (Black Watch) and orchestrations and arrangements by Tom Kitt (Next to Normal), the result is an experience Rolling Stone declares "a groundbreaking musical event!"
The Pantages Theatre
May 13 - 18, 2014
More details at Broadwayla.org: HERE


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Ahnu believes that collaboration inspires innovation and innovation inspires collaboration and it shows in their products. Ahnu is a small team that works together, plays together and thrives on shared inspiration. That philosophy continuously improves their products and adds to the fun.
The name "Ahnu" is derived from the goddess of balance and well-being in Celtic mythology. The choice is both deliberate and appropriate, as they strive to balance work and play, as well as business goals with social and environmental responsibility.
Ahnu. Walk new ground.See our most popular Ahnu below or discover the full selection by choosing a category at the left.
Outdoor Adventure Blog | Visit Our Outdoor Store near Orlando, Florida | Adventure Travel Resources
Toll Free: 1.800.643.3629 In Orlando: 407.831.0777
1101 E Altamonte Drive, Altamonte Springs, FL 32701
e-mail: info at TravelCountry.com
© TravelCountry.com 2011.


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Six Essential Tips for Async
- 7 parts
Async involves some new concepts. They're not difficult; just unfamiliar. Over the past year Lucian Wischik has been watching how people use Async in C# and VB. This series distils out the six essential async patterns and anti-patterns.
- In Order
- Recent
- Most Viewed
- Top Rated