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Safe in His Arms, Under Texas Stars Series #2 -eBook
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|Format: DRM Protected ePub
Vendor: Thomas Nelson
Publication Date: 2013
Availability: In Stock
Series: Under Texas Stars
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Publisher's Description
Sometimes it takes a stranger to see you as you really are.
Born and raised on sprawling Texas land, Margaret OBrien prides herself on her competence as a rancher. But her father believes shes made for more than just dawn-to-dusk work. He wants her to have the love of a good man, to raise children, to build a life. But Margaret gave up such dreams years ago. Shes convinced no man would have her, that the ranch is her life now.
So when Margarets father hires Daniel Cutler as a new foreman, shes frustrated and suspicious. Then an overheard conversation links him with a gang of bank robbers, and shes downright worried. Daniel swears hes not involved, but Margarets not convinced. She knows the man still has secrets. But would a criminal be so kind and talk so convincingly of his faith? As a series of tragic accidents threatens all she holds dear, Margaret must decide what to trust: her own ears, her best judgment . . . or what her heart keeps telling her.
From the author of the best-selling Blue Moon Promise . . . an exciting tale of danger, romance, and faith played out under Texas stars.
Romantically tense, but with just the right touch of danger, this cowboy love story is surprisingly cleverand pleasingly sweet. USAToday.com for Blue Moon Promise
Author Bio
USA Today bestselling author Colleen Coble has written several romantic suspense novels including Tidewater Inn, Rosemary Cottage, and the Mercy Falls, Lonestar, and Rock Harbor series. Visit her website at www.colleencoble.com Twitter: @colleencoble Facebook: colleencoblebooks
Product Reviews
ShannahAge: 25-34Gender: female5 Stars Out Of 5I devoured this book!January 16, 2014ShannahAge: 25-34Gender: femaleQuality: 5Value: 5Meets Expectations: 5I devoured this book, much like I did the first one! Margaret O'Brien is a character any female can relate to. She is full of insecurities and doubts. To cover those insecurities, she's thrown herself into ranch work and earned the respect of the townspeople by her hard work and competence. She doesn't think anyone can have serious intentions towards her, not even the God she loves so much. Can Margaret overcome her insecurities to accept God's unconditional love? Daniel Cutler is the new foreman on the Triple T Ranch, much to Margaret's dismay. He stirs feelings in her that she doesn't understand because of his compassion, kindness, and loyalty. But he has secrets that he can't share with anyone. Can he do what he set out to do without destroying the woman he's fallen for?
The plot will grab your attention from the beginning. As soon as Daniel shows up on the ranch, strange "incidents" start happening. These incidents threaten all Margaret has worked so hard for and she is determined to get to the bottom of it, starting with Daniel's connection. Daniel is dismayed that he's brought danger to the ranch. As his feelings for Margaret grow, he becomes more determined to finish what he started so he can move on with his life, hopefully with the red-headed beauty. There are plot twists and turns that keep you guessing until the very end and I loved every minute of it!
The message of the book begins and ends with learning to accept God's unconditional love. That's a hard message to get across in a society where love is conditional. Colleen Coble does an excellent job of weaving the message throughout the book, as she always does. She helps Margaret and the reader realize that you are safe in the loving arms of God, our father.
Overall, this was a fantastic book and I look forward to reading more from this fantastic author!
Britt98Grand Prairie, TXAge: 35-44Gender: female4 Stars Out Of 5Danger and Romance in TexasJune 23, 2013Britt98Grand Prairie, TXAge: 35-44Gender: femaleQuality: 5Value: 5Meets Expectations: 5Safe in His Arms is the second book in the Under Texas Stars series. This story follows Margaret O'Brien, only daughter of a successful rancher. Margaret has some pretty serious insecurities that hinder her relationships with others. She never feels that she measures up and views herself as unattractive. Enter Daniel Cutler, who has just been hired on as the new foreman to the ranch. He has some big secrets to hide. A natural attraction develops between the two. Daniel seems to love God and appears to truly believe Margaret is beautiful and the woman for him. But will this attraction be able to survive Margaret's insecurities and Daniel's secret? What is true and who is trustworthy? Colleen Coble does a good job at setting up a good, old-fashioned Western mystery novel. Only at the end of the novel is all truly resolved and are things made clear. I received a fee copy of this book from Thomas Nelson through NetGalley in exchange for my honest review.
The Happy ReaderColumbia, TNAge: 35-44Gender: female5 Stars Out Of 5Thoroughly Enjoyable!May 9, 2013The Happy ReaderColumbia, TNAge: 35-44Gender: femaleQuality: 5Value: 5Meets Expectations: 5This is fiction with a purpose. And what a purpose it is.
Meet Margaret O'Brien, daughter of wealthy cattle rancher Paddy O'Brien who can only see her many faults.
Fiercely loyal, prickly, and stubborn (like any true redhead), Margaret must overcome many issues that keep her from believing that God can truly love a misfit such as she.
Margaret struggles with things that many young and more mature women today must face and deal with on a daily basis. We, who are naturally hard on ourselves, often forget that we were created without mistakes by a God who loves us ~ just as we are. It's up to us to embrace His will and plan for us to be truly happy.
This is a heartwarming tale. Fraught with danger and excitement, this book will steal your afternoon. And you may find yourself a better person for it.
My thanks to the publisher who provided me with a copy of this book to review in exchange for my honest opinions. These opinions are my own, and they are exactly what I think.
PatsdreamHuntsville, ALAge: Over 65Gender: Female5 Stars Out Of 5Murder, Bank Robbers, Secrets, AccidentsMay 2, 2013PatsdreamHuntsville, ALAge: Over 65Gender: FemaleQuality: 5Value: 5Meets Expectations: 5Margaret runs the ranch for her father but he thinks its time for her to be a "lady" and find a husband. He hires a new foreman. Over heard conversation casts doubts on the new foreman Daniel Cutler. Unexplained accidents, bank robberies, murder and other secrets. Can there be anyway for these two to fall in love with all the doubt and secrets? Colleen's faith, her sense of humor and her love of story telling really shines. For someone that didn't read westerns until last year, this was terrific.
wfnrenSt Cloud, FLAge: 55-65Gender: female5 Stars Out Of 5Just as good as the first book in this series!April 18, 2013wfnrenSt Cloud, FLAge: 55-65Gender: femaleQuality: 5Value: 5Meets Expectations: 5Margaret O'Brien was born and raised on a Texas ranch and lives with her father. Her mother was killed in a stampede and her brother was shot by Texas Rangers. Bank robberies are happening in the surrounding towns when her father hires a new foreman without telling her. This upsets Margaret because she has been the boss of the ranch for many years and has increased the value of it, why would her father do this to her. Not only has he hired Daniel Cutler, a stranger, he brings her cousin Lewis back and has changed his will leaving the ranch to Lewis with a huge amount of money to Margaret. He is also demanding that she start dressing and acting more like a lady, Margaret in a dress, she doesn't like that order at all.
Along with all the changes someone is trying to kill her father and snooping around the ranch. Just who is Daniel Cutler and what is he up to? Bank robberies, attacks on her father and he doesn't seem like a true cowboy, dresses to neat and no callouses, although he does seem to know what he's doing when it comes to ranch work. It seems like every time she turns around there he is, she even over hears conversations he's having with people she doesn't know and from what she's hearing she does not trust him. Is Daniel the one trying to kill her father, is it Calvin, one of the hands who seems to be holding a grudge about something, because surely it couldn't be Lewis or Vincente, Vincent is the maids son and was born and raised on the ranch as was Margaret?
I loved the first book in this series and this one was just as good. I really like Colleen's writing and it doesn't take me long to get through her books. Good, clean, a touch of romante and some old fashioned 'old west' action to boot!


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Gyorko's hard work pays off
April 3, 2013
MORGANTOWN — If you are a West Virginia baseball fan, you have to be proud of Jedd Gyorko....
Why is it "unfortunate" that Greg Van Zant was replaced? This is fortunate for all future WVU players. There would be other MLB position players from WVU had Greg never been the coach.
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Thursday, July 17, 2014
Never let it be said that Im not a sentimental guy.
I get emotional with the best of them and this week I touched on three of my list of Five Things That Make Me Cry.
I got a little bit weepy.
And when I say weepy, I dont mean sucking back a few sniffles and blinking away the stray tear. Im talking about full-on, rib-heaving sobs with drool line trailing from the lower lip.
There are five things on this earth that will make me do that. They are: 1. Ceremonial baseball moments; 2. Bagpipes; 3. Superman; 4. Weddings, and 5. Happy endings.
These things are my kryptonite. I am powerless against them.
When LeBron James announced he was leaving Miami and returning to the Cleveland Cavaliers I got a little weepy. Four years of hatred and resentment were washed away with one stroke of the pen.
I am a LeBron James fan again. All is forgiven. Hes coming home.
Now I hate the Houston Rockets and Dwight Howard because nobody wears a Superman cape and then plays basketball like Howard does. Thats a disgrace to the bath towel.
Plus, he abandoned Kobe.
Bagpipes get me the same way. And the pipers dont even have to start playing for the brain rains to come. All I have to hear is the snick of the snare drum and Im a goner.
I saw a You Tube video of the Bad Piper, some dude in a skirt wearing a bad mohawk playing AC/DCs Thunderstruck on the bagpipes.
I started crying.
Its Thunderstruck. Nobody cries at Thunderstruck. But I do.
I really dont have to explain this next one. Just let me say one word: Superman.
I believe a man can fly.
I remember the first time I ever saw a Superman comic. It was 1966. I was eight. I was on vacation and noticed the comic book rack positioned near the front counter. I saw the red cape and blue tights, dashed to the linen closet looking for the nearest bath towel, and started wearing my Fruit of the Looms outside my pants.
My parents talked to me for a long time about that one.
Son, do you know you are wearing your underwear outside your pants?
Yes father, thats how Superman wears his.
Thats when I noticed my dad had developed this nervous kind of eye twitch.
I also tear up at happy endings, when the guy finally gets the girl. Thats the reason why I sit in the front row during movings.
I just have to be careful not to sniff.
Romantic comedies are my favorite as they arent so serious but theres always that spice of romance at the end.
I love it when the guy gets the girl.
And last, weddings. Specifically, any family members wedding.
I drove half way up the east coast last week to attend my nieces wedding over July 4 weekend in Williamsburg, Virginia, the capital of Fourth of July celebrations apparently as everybody and their brother descended upon Colonial Williamsburg and everybody got there ahead of me.
The chapel was an old English style chapel where the congregation faces each other rather than face front.
My Adams apple was bobbing like Sugar Ray Leonard and I bit a hole in my lower lip. All this because they hired a harpist to play the wedding music.
Forget about when the bride walks down the aisle. I walk into the church, sit down and grab a hanky.
And everybody knows its coming too. Especially when I do the hehehehe shoulder heave.
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on May 9, 2013 - 8:29 AM
Exhibits, lectures, music and a boat launch are planned during Stars Along Scajaquada, an event commemorating War of 1812 activities along Scajaquada Creek, from 6 to 9 p.m. May 18 at the foot of Peter Street off Amherst Street near Assumption Catholic Church.
Sponsored by the Historic Preservation Committee of the Black Rock-Riverside Good Neighbor Planning Alliance, it's free and open to the public.
Historians will lecture at 6:30, 7 and 7:30 p.m.
There also will be a small-boat launch into the creek from the Buffalo Maritime Center, lighted stars hanging from the trees along the creek, a blacksmithing demonstration, horse and buggy rides, War of 1812 re-enactors and music of the era from the Irish Volunteers Music Group.


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Off-Campus Study
Grinnell is affiliated with nearly 100 off-campus study programsworldwide, and we offer two of our own: Grinnell-in-London and Grinnell-in- Washington. By the time they graduate, 55-60% of all Grinnell students have studied in a semester-or year-long program, either domestic or overseas.
As an adviser, it's important to raise the topic of off-campus study (OCS) early with your advisees. Although they will not be eligible to study off-campus until their fifth semester at Grinnell, planning should start sooner. Students typically learn about programs and apply during their second year, but this process can start sooner if you direct it. Although studying in a new environment is a valuable learning experience in and of itself, the College believes the opportunity will be even more enriching if closely integrated with a student's coursework on campus. During the application process, great emphasis is placed on selecting a program that is compatible with academic goals, thus close planning among the student, his/her/hir adviser, and the OCS Office is advised. Further information is available on the OCS webpage.


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This season's dynamic lineup of stars -- including a sitcom legend, a reality mega-star, a football champion and a pop music sensation - will perform for the first time on live national television with their professional partners during the two-hour season premiere of "Dancing with the Stars.
Dancing With The Stars: Week 1 Rehearsals (Part 1)Published 2:29 PM CDT Sep 13, 2013
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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on January 17, 2013 - 10:59 PM
A limited number of $500 sponsorships are being offered by the Erie Canalway National Heritage Corridor for events and festivals taking place along or near the canal system between May and December.
To qualify, events must promote or highlight the canal corridor's historic, cultural, scenic or recreational features.
Deadline for applications is Feb. 11. For information and applications, visit www.eriecanalway.org and click on "Grants and Funding" under the "Get Involved" link.


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The Durango High School girls lacrosse team isn�t as happy about opening its season at home as one might think.
Not only did the Demons lose their first three games to the weather � all to be played on the Front Range � the long-lived Four Corners snow took their field lines, too.
By Wednesday afternoon, the Demons hadn�t yet gotten a single practice on a properly marked girls lacrosse pitch. They will open Mountain League play against Fruita Monument at 4 p.m. today at DHS, before league play keeps rolling at 11 a.m. Saturday against Aspen.
�We haven�t been outside as much as we�d like,� DHS head coach Jenni Darlow said at Wednesday�s indoor practice. �There�s no room for error; there�s no room for �We can fix that later.� We can fix it today and tomorrow.�
Just how much does Durango need to fix?
Even after losing a bevy of key players last year, probably not a whole lot, said Darlow, last year�s Mountain League co-Coach of the Year.
Her top goal for this year involves more goals. Scoring them, that is � �more offensive production, more goals.�
�Not from one person, either,� she said. �I think we�ll have three or four top scorers.�
Last year�s 10-3 team was defense-heavy. It didn�t score many goals, but it didn�t need to.
This year, Darlow wants to see some scorers step up, starting with senior Alyssa Montoya, last year�s assist leader.
�I think it�s definitely motivation for myself and also maybe to be a leader,� said Montoya, daughter of Richard and Victoria Montoya.
�I�m just ready to play lacrosse.�
Sara Martin, who missed last season with shoulder surgery, will provide a boost in the midfield transition with her stick skills, Darlow said, while Hannah Quick makes the move from low defense to low offense to add some more scoring firepower.
�That girl can shoot,� Darlow said. �I expect her to have a pretty big impact.�
Still, in the program�s fifth year, Darlow doesn�t want a ramped-up offense to rise at the expense of her defense.
�I don�t want to see a letdown,� she said.
DHS freshman Shaelee Hawkins should provide some new blood with �stellar defense� with the help of sophomore Kelsey Pool�s �real knack for interceptions and deflections.�
In fact, Darlow said she�s comfortable with her pieces at all of the field positions.
The only big question is how to replace goalkeeper Alyssa Spencer, who�s off to a 4-3 start for the Fort Lewis College�s women�s lacrosse team after graduating last spring.
DHS senior McKenna Rigdon will try to play the part.
A transfer from Missouri, Darlow said she�s still getting used to the defense and Durango system, especially after not having played goalkeeper since her freshman year.
But ready or not, lacrosse season is here.
�I think we�ve got a good group,� Montoya said. �I think we�ll do good.�


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Volunteers helping the victims of the hostilities between Israel and Hezbollah are finding it extremely difficult to reach affected villages and towns due to indiscriminate bombing. According to volunteers, the Israeli army has been shelling their routes, hitting civilians, humanitarian aid workers and volunteers. Such life-threatening situations can easily dampen spirits and discourage anyone. But volunteers on both sides of the Israel-Lebanon border are committed – to the extent of endangering their lives – in providing emergency relief and evacuation support to the displaced and injured.
This photo gallery documents the invaluable humanitarian assistance provided by these courageous volunteers, most of them local people - and in some cases refugees and victims themselves.
Read related articles in our special coverage of the Middle East crisis


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Code for America: A New Kind of Public Service | Opensource.com
Code for America: A New Kind of Public Service
Government can be seen as an answer to the often messy question of collective action. There are some things people need together, but since that's not easy to coordinate, we set up institutions to do so. Over time, the government's focus and expectations developed -- understandably -- to a place where it was seen less as a coordinator and more as a service provider. This is what some call the vending machine model of government. My tax dollars in, a safe and well-kept community out.
But, as we're all seeing now, that machine is profoundly broken. Buckling under the weight of the budget crisis and burdened with ever-increasing demands from its citizens, governments are unable to provide those services we've come to expect. The federal debt is in the trillions, many cities and states are nearing bankruptcy, and some already have. And so this analogy needs to change. Government can't be a vending machine any longer; it must be a building block, something we use together to create the communities we hope to live in.
While this all may sound airy and abstract, in a real way, this already happening, just not as much in governance. Open source projects have captured this spirit: you build together, developing solutions for yourself and for the common good. Think of GitHub as an example. As an institution, it's merely a platform for collaboration and development. It provides the tools, ranging from version control to hosting, that allow people to come together to build. And when they do, each is rewarded with not only the satisfaction of contribution, but also its public recognition. You help yourself while you help your peers, and along the way, you create value for the entire community by providing a useful service.
This is the model we at Code for America hope to enshrine in government, open sourcing not just its software, but its mechanics. We want to redefine the role of the citizens for a 21st century democracy, where they are working hand-in-hand with government to make it better. To do so, we must breakdown the barriers to entry and create new and easy ways to get involved. And that's exactly what we're trying to do with the CfA Fellowship program. We are developing a new kind of public service.
Inspired in part by Teach for America, the Code for America fellowship recruits the brightest minds of the web industry into public service to use their skills to solve core problems facing our communities. Through our one-year fellowship program, talented web developers, designers, and entrepreneurs leverage the power of the Internet to make governments more open and efficient. Right now, interest in both technology and civic issues is peaking, and a generation of young people are eagerly looking for ways to give back. We are building our fellowship program to give these emerging leaders a path into government and public service.
Our current focus is on cities, and partnering cities apply through a competitive process by describing a problem space for our fellows to tackle. Throughout the year, the cities and our fellows work together, along with a team of industry leaders and thinkers, researching, brainstorming, and even co-developing the solution. But the projects are only part of our goal; we're also developing leaders. We couple the project development with professional development, networking, and mentoring, so the fellows are not only civic-minded but also successful after the fellowship.
For our inaugural 2011 program, we're working with Boston, Philadelphia, Seattle, and Washington. To take on these projects, we chose 20 fellows out of our impressive applicant pool of more than 360 to come on board in in January. But those fellows are only a small fraction of the team we'll need to succeed in the year and more broadly.
How can you help?
Join CfA Labs Volunteer Corp: To help on our 2011 projects and a host of other issues we're seeing in cities, we're recruiting coders and designers who want to volunteer, but don't have a year to give. There is a lot of work to do, and we can use any support you've able to give. Join the discussion group.
Get Your City to Code for America: We just opened up the application process for our 2012 City Program, and we are actively seeking local governments who want to engage with our fellowship program. City representatives can begin the application process online, and for everyone else, we've also put together some tools to get their attention and make some noise in our Citizen Action Center.
Get involved however you can. Together, we can code the next chapter of America history.
6 Comments
Thru the ages, there have been many models of government that have been tried. One of the big strengths in Open Software is the concept of Freedom. This is essential, not only in software, but in Government as well.
All coders are familiar with the KISS principle of building code. The same is true with Government. That's why the folks that came up with the crazy and revolutionary idea for OUR government embedded the KISS principle within our Constitution.
This means that government CANNOT act as a vending machine, or a panacea to provide a convenient nexus for coordination of activity. Government, in order to be able to function, must have Power. The corruptive influence of that power must be contained, therefore Government itself MUST be constrained to performing only the most basic functions of Justice and rule-enforcing. Once you step beyond the boundaries that were clearly set at the start of this crazy ride, you see the wild meanderings that we witness today.
Freedom is at the core of what makes open software, and open government work. It is easy to step beyond the bounds, and hard to turn that back.
Great idea. Can this be applied to www.peertopatent.org? Peer to patent is a social media site for outside experts to assist in patent examination. It got off to a good start, but the software hasn't been updated in three years.
I suppose the writer also believes that high-speed Internet Access is a Constitutional right? Reader: please look up Center for American Progress (with which the writer is affiliated) and see how much REAL freedom and democracy they espouse. They are funded by George "I destroy currencies and make billions off it" Soros.
Check out the CAP Annual Report, which highlights their involvment in that freedom-killing bill known as health-care reform:
By the way, by engaging in capitalist tactics, the CAP's benefactor (Soros) made millions off the US oil production shutdown in the Gulf of Mexico by investing in a Brazillian oil company.
Dear Opensource.com,
Please keep the progressive left's social justice political agenda out of the open-source software arena.
I made money trading on the gulf oil spill catastrophe, too, it was a no-braniner for any competent investor. Being educated and acting intelligently are not crimes, regardless of right-wing attempts to classify them as such. Stay home and pray while your betters work to build the future.
I'm glad to hear you embrace capitalism and free-market principles.
I have to ask though, why all the mean-spirited rhetoric? Your comment is overflowing with intolerance towards a person and,even worse, towards an entire GROUP of people whom you perceive to hold a view differing from your own. Can we please just try to be tolerant and accepting of everyone?
Actually, the ideas presented in the article are not that bad. In my mind, the author may be tainted by the association with CAP, but that just means that you have to apply a bit more scrutiny to his post.
CfA does not sound like a bad idea, keeping in mind that the person who develops code is free to do whatever he wants to do with it, in keeping with Conservative principles. Collective action is neither a product of the Right or the Left, but is the basis of a lot of good that is done (and done rightly) for the country.
After all, if this member of the CAP has his hand out asking for help, you know that he's not using the same hand to pick your pocket.
(With his origin in the CAP tho... Keep an eye on his other hand! ;-)


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Top Definition
A really funny girl who is very sexy and smart, she is always flirtatious and brilliant at sex!
Oh my god i scored with this chick last night she was amazing and she's hot......yep she must be a maddie!
作者 Katheryn 2004年1月04日
Trending Now
Can you define these popular missing words?
Maddie is the bestest friend you could ever have! She is a very loving and caring person. She is one of those people you can talk to for hours over the phone and not get. She told me to truly tell my feelings about her on here about her on here so I will. I think you are one of the most amazing girls a guy could know and you know that I like you. I love you!
Woah look it's Thomas, but who cares there is Maddie!
作者 I love Maddie Duh 2009年4月06日
An absolute awesome girl, who is always super energetic. She will always be happy and make everyone happy around her. A Maddie will also not enjoy leaving friends, but will have a great time with all of them!
She is so happy and energetic. She must be a Maddie.
作者 superawesomefriendsperson 2010年2月23日
Pet form of Mad- names
Originally a pet form of Madeleine and Madeline.
Maddie can be used as a nickname for other 'Mad-' names, including Maddox, Madden, and Madison.
Mostly used in English speaking countries
Origin/Culture : British
Pronunciation: (MAH dee)
Originally a pet form of Madeleine and Madeline.
Maddie can be used as a nickname for other 'Mad-' names, including Maddox, Madden, and Madison.
Mostly used in English speaking countries
Origin/Culture : British
Pronunciation: (MAH dee)
Maddi Jane or Maddie Fitzpatric or Maddy Drew
作者 Supercool1234 2010年10月26日
A very sexy girl, who usually flirts a lot. Funny. Shy. And loves to have sex.
Whoa, Man. Last night Maddie came over and she is brilliant at sex, I mean BRILLIANT!
Dude, I need a Maddie.
Dude, I need a Maddie.
作者 WollyHood 2008年4月02日
A very pretty very sexy girl. Usually a brunnette who is funny and smart. A maddie is hard to find so if you are lucky enough to find one hold on to her forever. Usually a very popular girl as well. Soulmates name is usually "Riley" or "Nick".
veryyyyyy hott girl is sooooo a Maddie!!
作者 xxxjbxxxlvrxxx 2008年10月29日
Maddies are very special people. They are smart, funny and fun to be around. They are very artistic, sweet, loving, kind and good in bed, or so I am told. Anyone dating or anyone who has or will ever date a Maddie is truly a very lucky person!!!
Wow my girlfriend is suck a perfect person, yes, she is defiantly a Maddie!
作者 idontreallyfeellikeusingmyreal 2009年4月30日


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End of the Year CookoutLocation: SRC Pavilion (pavilion beside roller hockey rink)Date: Tuesday April 26 at 3:30 pmAll military and their friends are welcome
Interested in joining the SVA? Email Hunter at email@example.com. Meetings will begin on Tuesday september 4 at 3:30.
Contact UsOfficersPresidentHunter GladfelterVice PresidentRyan GirtonTreasurerCody BrynerSecretaryJosh HowellYou can email Hunter at email@example.com if you have any questions or want to join.
Veteran's Service OfficeBox 191871 Old Main DriveShippensburg UniversityShippensburg, PA 17257
"The first signs of stress for many combat veterans appear 3 to 4 months after returning home"
Army Times January 7th, 2005
Consequences:Leads to acting out anger more often, use avoidance and isolation to cope
Shippensburg University and Shippensburg University Student Services, Inc. recognize more than 100 student-centered clubs and social organizations. The University provides web space for these sites, but the sites are created and maintained by the students.


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Systemwide Events Calendar
Passion in Paradise: Argentine Tango for EveryoneDecember 31, 2:00pm - 2:00pm
Manoa Campus, UHM Physical Education Complex Studio 3
Learn the fundamental elements of tango that will allow you to dance on the dance floor. The course is meant for complete beginners or those who have some experience and want to practice or improve their basic tango technique. Topics include the essence of leading and following, musicality, fundamental linear, rotational and traveling movements, leader and follower technique, social dance etiquette and moving around a crowded dance floor.
No partner or previous experience is required. Wear clothing that is easy to move in and shoes that are tied or strapped on the feet with leather or slippery soles to facilitate ease of spinning and movement on the floor. Each class is 1 1/2 hour long.
Event Sponsor
UHM Outreach College, Manoa Campus
More Information
Jennifer Small Griswold, 831-239-6529, firstname.lastname@example.com, whttp://www.outreach.hawaii.edu/noncredit/courses/programdetail/2334
|Friday, August 30
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Cell & Molecular Biology Final Oral
Manoa Campus, Biomed Bldg Manoa IBR Conference Room
|"Japan's Democracy at Risk" L. Repeta
Manoa Campus, Richardson Law School Moot Court Rm.
|Movie Night Fast and Furious 6
Manoa Campus, Campus Center Ballroom
|Movie Night Fast and Furious 6
Manoa Campus, Campus Center Ballroom
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- Arts Exhibition: Peranakan Chinese Heritage of Southeast Asia
- The Wonder of Learning: the Hundred Languages of Children Exhibit
- Waikiki Parc Features Nicole Naone
- Course Reserves Deadlines and Information
- Open At-Large Student Senator Seat
- Thinking Design: Creating Memorable Images with Duane Preble and Philippe Gross
- Diversity and Equity Initiatives Fall 2013


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Police say a man pulled a knife on a state police trooper who was responding to a domestic dispute in South Middleton Township, Cumberland County.
The incident happened Sunday night around 10:35 p.m. along the 40 block of Cardinal Drive.
Police said the accused, Roger Moore, 39, of Mechanicsburg, had choked and struck a 38-year-old woman, causing her to flee the home.
Police said when the trooper arrived he tried to speak to Moore, who pulled a knife. Moore then locked himself in a bathroom, according to police.
Eventually troopers were able to force their way into the bathroom and arrest Moore.
Moore is charged with aggravated assault, simple assault, harassment and terroristic threats.
Photos: Recent Susquehanna Valley arrests


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30 minutes of Good Barry
- Posted: May 25, 2008 at 9:10PM
Right click "Save as…"
Managing a micro-business online, or offline, usually involves paperwork. Lots of it. From customer enquiries to invoicing, the tracking of your biggest concern: the customer, is a tough task.
Shouldn't computers and the internet make business easier?
You could just create a blog. Then add an email follow up system. Then another customer birthday card system. Very soon you are moving your data across too many diverse systems.
GoodBarry, a winner of the Transaction 2.0 "Best Aussie Business Startup" at last week's CeBIT conference in Sydney, is the perfect answer.
Recently highlighted for their innovative marketing, in this video interview we see an in depth demonstration of GoodBarry.
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Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


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(based on 7 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Reviewed by 7 customers
Displaying reviews 1-7
Back to top
My favorite pen
By Tricia
from Brookfield, W
Comments about Lamy AL-Star Rollerball Pen:
This is my second All-Star and I love it. To me is the best pen, easy to use rollerball is soft on paper, comfortable, stylish and different. Like all LAMY products, quality is fantastic. Cooper color is true to what you see on this site.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
(1 of 2 customers found this review helpful)
good looking, but poor quality for price
By Taxman
from Patriots Nation
Good pen but poor quality for the price
Merchant response: Levenger is grateful for your feedback on our Lamy AL-Star Rollerball Pen. I am sorry to hear that this product did not meet your expectations. We have communicated your concerns to our product development team for review. Our records indicate that your return was received, and a credit was process back to your Levenger account. If you should need additional assistance please contact our customer service center at 1-800-544-0880.
Nice pen
By OHNO
from Methuen Massachusetts
Very nice pen...enjoy writing with a good quality pen.
Form and Function combine
By MrsM
from Maui
I love writing tools, and this Lamy is an ideal all purpose instrument. The tip is bold enough to be easily read but fine enough to accomodate my relatively petite script. It's lightweight and balanced and will make a great travel pen.
My Go-To Pen
By WriterMom
from Los Angeles, CA
Love this handsome pen! Writes like a dream. My very favorite.
(2 of 2 customers found this review helpful)
Great pen
By LovesOfficeSupplies
from Boston, MA
I got this pen as for writing field notes for graduate study. I'm very pleased with the purchase. The pen is much lighter on the hand than other cherished pens I own. I find that my hand does not get as fatigued while writing, which is an issue for me as a lefty. Compared to the plastic version of this pen, the aluminum has more substance in the hand.
Great finctionality
By Buya
from New York City
I've bought several Lamy pens. This one I bought for a friend as a gift for his new job. We are aficinados of good ink pens. This a good everyday pen with the function of a high end ink pen and the sleek look of a modern pen. We are very pleased with the smoothness of the writing nib and the look it leaves on the paper. Even in our high tech enivronment we still enjoy a good writing pen. Thanks for the craftsmanship and quality.
© Copyright Levenger Company
2016. All Rights Reserved.


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Average Ratings
5 out of 5 people recommended this car.
Consumer Reviews
2 month review
by Corvette Jack from Framingham, MA | September 22, 2012
So with about 100k on the car, I expected more issues but so far, I've fixed anything that's come up. It screams when I want to fly or race. The targa top is convenient and you don't pay as much on insurance as you would a convertible. So far, I've done the oil change, brake fluid, swapped a courtesy switch (not expensive), a blown amp, and I've bought the weatherstrip kit. The frame and underside of the car are so immaculate, for what I didn't spend buying the car, putting a little money into it is worth it to preserve its great condition.
Purchased a new car
Uses car for Just getting around
Does recommend this car
The perfect ride looks,speed,and all the above
by 91c4vette from mahomet,IL | January 9, 2012
The car started right up a great dealer ship with the price had a lot of mods. with even a better price
Purchased a new car
Uses car for Having fun
Does recommend this car
My Red Corvette
by Vette 1991 from New York, NY | September 20, 2011
I final realized my dream of owning a corvette. Every-time I looked at a new one it was always just out of my reach so I decide to go vintage (great decision) and found a 1991 hatchback red corvette with two tops (completely stock). I can't be happier. It's has a 5.7L (L98), 245 hp V8 with a 6 speed manual transmission. The car is in perfect condition. People can't believe the car is a 1991 with only 68K miles. What a pleasure to drive on sunny days. I find myself smiling ear to ear every time I drive the car and the best thing it's only sits two. The corvette when originally purchased has just about every option that was offered in1991. The car has enough power to get up to speed very quickly and the handling is excellent. If you are looking for a corvette think about the C4's (1983 – 1996) model years. It was reasonably priced, in excellent condition, has proven reliability, and it make you feel great when driving the car. Being over 6 foot (fit with no problem) it's an art getting in and out, but that just contributes to its uniqueness.
Purchased a new car
Uses car for Having fun
Does recommend this car
Wonderful car for the money
by C4 Vette Guy from Iowa | April 20, 2009
My 1991 Vette is the 2nd one which I've had. It is much improved over the 1986 model. Plus, all the exterior designs (square tail lights & wheels) are used from 1991 thru the end of the C4 Corvette series in 1996.
Purchased a new car
Uses car for Having fun
Does recommend this car
by Sports Car Enthusiast from Dubuque,Iowa | January 12, 2009
I have owned 6 vettes Trans Am,Camaro, Mustang,Triumph,etc.Bang for the buck,can't beat it. The 91 I bought in May is everything I hoped it would be,it has 245hp,adaquate,6speed got 25.3mpg on 800k trip. Nuff said.
Purchased a new car
Uses car for N/A
Does recommend this car
Featured Services for this Chevrolet Corvette
- Sell your current car quickly and easily on Cars.com.
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- Get help with car repair now on Cars.com. Visit Repair & Care


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Top Definition
Diarrhea and/or amoebic gut infection sufferred by foot soldiers serving in Europe in WWII.
Dad complained that hen he was captured by the Germans, he had the green apple dirties until he was liberated.
Por Rveil 19 de julio de 2004
Trending Now
Can you define these popular missing words?
Diarrhea and cramps, especially when caused by eating too many green apples.
Don't eat too many green apples or else you'll get the green apple dirties.
Por t.h. 03 de noviembre de 2003


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Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.
Whether you need a cancer screening, ongoing treatment, or support during recovery, Community's cancer experts are here to help. With our comprehensive, integrated oncology programs highlighted by our collaboration with MD Anderson Cancer Network®, we are changing the way cancer is treated in Central Indiana.
Community Cancer Centers are not just centers; they are a continuum of the best oncology services available throughout Central Indiana. For more information about cancer care services or to request an appointment, please call us toll-free at 800-777-7775.
Request an appointment with an MD Anderson certified doctor today! Call 800-777-7775 or find a doctor >>
See more of our awards
More about shops


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San Francisco was founded in 1776 by Spain but it wasn't until the Gold Rush of 1849 that the population began to swell. Since then the city has grown into a bustling international town that manages to maintain a mellow vibe. San Francisco is unabashedly hip with a pride of place seen in everything from its historic cable cars to its love for locally produced food.
Drive over the scenic Golden Gate Bridge to the Marin Headlands. Hike through the lush green peninsula and take in the views of the city. On your return trip, explore the Civil War-era fort at Fort Point National Historic Site. Tour San Francisco City Hall, a Beaux-Arts beauty, and make sure to look up - the dome is a replica of St. Peter's Basilica in Rome.
Sip a cappuccino-macchiato mix called the Gibraltar at Ritual Roasters in the Mission District. Enjoy the bounty of the sea with Dungeness crab melts and bowls of steaming cioppino at Woodhouse Fish Company. Order a delectable Vietnamese sandwich for takeaway from Out the Door, the smaller and less crowded version of Slanted Door.


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The original list of All-Sierra League players that was released last week did not include the Division III first team, which was done separately of the Division I-A and was not received until Monday.
Both North Tahoe teams fared well in first-team voting, while the second team and honorable mention, which ran Friday, combined the players from the Sierra League's two divisions.
The awards were voted on by the league's coaches.
North Tahoe junior goalkeeper Angela Wood was voted defensive MVP for the girls, and senior Riley McCarthy was voted defensive MVP on the boys' side.
Emily Pieper was named to the DIII first team as a midfielder and Kami Abi-Nader as a defender.
In boys' voting, Trevor Semmens and Eduardo Martinez were named to the first team as forwards, Francisco Medina and Wildon DesLauriers made the first team as midfielders, and Nico Monforte as a utility player.


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How To Stay Sane And Organized While Christmas Shopping
Now that the craziness of Black Friday and Cyber Monday are past us it's time to get organized!
Christmas shopping can me extremely stressful. There's nothing more embarrassing than forgetting to buy a gift for someone, especially if they've give you one. And there's nothing more annoying than getting home from a long shopping trip and realizing that you forgot something you needed from one of the stores you were just shopping at.
We want to help you stay sane and organized this holiday season. That's why we've created a Forget-Me-Not Shopping List and Shopping Planner just for you! Just click on the link for a printable version that you can keep with you throughout the month so you always have your list nearby to edit and use!
The Forget-Me-Not Shopping List is a list of over 25 names of people outside of your family and friends who you may not see everyday, but should keep in mind around Christmas time. This list is a great tool to help you make sure you aren't forgetting anyone when you venture out to the mall. Not sure what gifts to give to the people on the Forget-Me-Not List? We've got you covered! Keep checking back here at A Personal Touch between now and Christmas because we'll be offering gift ideas for people straight off the list! You can add our gifting tips or your own ideas on the space we created for you right next to each of their names.
Once you've used the Forget-Me-Not List to figure out all the people you're buying for, add them and your family and friends to the Shopping Planner we've created for you! Here we've created an organized planner with space for you to write down each person's name, the budget you would like to stick to for each person, and a check list you can cross out after you've bought the gift, wrapped it and sent it! THat's right! A Personal Touch has got you covered from brainstorming the gift idea all the way to making sure it gets in the hands of the recipient.
With a little help from us your Christmas Shopping will not only be a breeze this year – it'll be fun and stress free! We hope you enjoy these tools we've created for you! If there's anyone you think needs to be added to the Forget-Me-Not list please leave a comment here, we'd love to hear your ideas! And don't forget to keep checking back for gift ideas that will help you with your Christmas shopping even more!
Happy Gifting!
Didn't find any related posts :(


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on November 9, 2012 - 8:01 AM
In 2007, Jason Bonham played the most hotly anticipated gig in rock history. Two weeks ago, the film of that gig had a brief run in Buffalo, and it was a mind-melting, heart-lifting affair. Jason was filling the drum throne for his late father, the revered, iconic John Bonham, and backing his father's bandmates, Jimmy Page, Robert Plant and John Paul Jones for Led Zeppelin's one-off reunion performance. One can only imagine the pressure the drummer must have been under. But guess what? He absolutely killed it. And he helped Zeppelin turn in a performance on par with the best of its past triumphs. (The film will be released on home video, CD and vinyl Nov. 19 as "Led Zeppelin: Celebration Day.")
There are tribute bands, and then there are bands like Zappa Plays Zappa and Jason Bonham's Led Zeppelin Experience, in which deeply talented sons carry forward the music of their fathers with passion, grace and integrity. Bonham and the LZE last passed through town in 2011, pausing to offer an inspired show inside the University at Buffalo's Center for the Arts. During that performance, singer James Dylan and guitarist Tony Catania greatly aided Bonham in summoning the might and majesty of Led Zeppelin's music. The band returns to do it again at 7:30 p.m. Monday in the Rapids Theatre (1711 Main St., Niagara Falls).
Tickets are $40 advance, $45 day of show (box office, www.rapidstheatre.com).
– Jeff Miers


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The IIEC is an affiliate organization and provider of Kauffman FastTrac® programs developed by the Kauffman Foundation.
For more information and to apply for the program, contact John Sossi at 956-882-4119 or firstname.lastname@example.com or visit utb.affiliate.fasttrac.org.
Contact Information:
International Innovation &
Entrepreneurship Center
Suite H3A
301 Mexico Blvd
Brownsville, TX 78520
Phone: 956-882-4119
Fax: 956-882-4222
Office Hours:
Monday - Friday
8:00 a.m. - 5:00 p.m.
The University of Texas at Brownsville website uses Javascript.
To access this page as it is meant to function please use a Javascript
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text:
Article Archive:
Legally Speaking - When justice fails
Nineteen-year-old Autumn Grohowski was on her cell phone with her dad, just letting him know she would be home soon. It was June, a summer night in Lebanon, Pennsylvania, and Autumn was approaching the trail she would take home. She was on her bike, and mindful of her safety, so she kept the call short — she told her dad "I don't want to be killed by a car, so I don't want to talk on the phone on the way home."
Those were her last words.
As she headed south on Fourth Street, Autumn, an award-winning student with plans to become a visual artist, approached the junction with the trail, which ran near a railroad track. She noticed that the railroad warning lights were flashing, and the safety arms were swinging down, indicating that a train was coming. No problem, her turn was just before the railroad crossing anyway, so she began to make her left turn, riding across the centerline, into the oncoming traffic lane, before turning onto the trail. She never finished her turn.
Gregory Moyer was driving north on Fourth Street. As he approached the railroad tracks, the warning lights were flashing, and the safety arms were swinging down, indicating that a train was coming. But Moyer was drunk, with a blood alcohol content of .14, nearly twice the legal limit, so when he saw the warning lights flashing, and the safety arms coming down, he gunned it, blowing through the railroad crossing. Or maybe he always blew through the crossing, drunk or not. Only Moyer knows. Regardless, Moyer was lucky this night — he wasn't hit by the approaching train.
Autumn wasn't as lucky. As she was approaching her left turn, Moyer blew through the railroad warning lights, and plowed into Autumn. The impact crushed Autumn's skull, broke her neck, arms, legs, and ribs, and collapsed her lungs. Without a thought in the world for the human being he had just run down, Gregory Moyer fled the scene. A short distance away, however, horrified witnesses forced Moyer to a screeching halt. Trapped by his captors, and forced to return to the scene, the drunken Moyer called 911 and reported that he had "just hit a little girl on a bike."
As the 911 operator took his report, Moyer repeatedly exclaimed "Oh, my God, Oh, my God."
Miraculously, Autumn wasn't dead. She was rushed to the hospital, and with her father Kris at her side, she clung to life. "When I got there, it looked like she was already dead," he said, "but they were saying to me she could still hear me." Kris stayed there by Autumn's side, as she stubbornly struggled to live, until, 30 hours later, the doctors removed her from life support. Her father held her in his arms as her life ebbed away. Recalling the moment, Kris said "I held her neck. And her heart stopped in my hands, you know. So it was very tough."
Thus began Kris Grohowski's long search for justice. In late October of 2007, four months after taking Autumn Grohowski's life, Gregory Moyer had not yet been brought to justice. In fact, the D.A. hadn't even filed charges in the case. Kris Grohwoski spoke out in frustration: "He should be charged with speeding. He should be charged with running the red light. He should be charged with homicide by vehicle for killing my daughter. I just want justice for my daughter, and that's all. I just want justice." Lebanon County District Attorney David Arnold responded with his assurances that charges would be filed.
And a week later, charges were filed … although they were not the charges Kris Grohowski would have expected for the man who took his daughter's life. Gregory Moyer was charged with DUI, hit and run with death, careless driving, and not yielding to railroad warning signals. He was not charged with homicide by vehicle, because District Attorney Arnold felt "there's blame on both sides."
As the District Attorney explained, "In this instance, Autumn Grohowski's actions also played a role in causing this accident and a pretty significant role in that. She was, by eyewitness accounts, traveling in the middle of Mr. Moyer's lane."
Thus, Autumn's killer escaped homicide charges. Still, Kris Grohowski felt some satisfaction that the man who took his daughter's life had been charged with something, that he wasn't going to escape justice, just as he had tried to escape the scene of the crime: "I'm finally relieved that there's been charges filed. As far as that goes, I know they're not heavy charges. But they're charges. It's a beginning as far as that goes." It says something, I think, about the state of criminal justice when the family of a drunk driving victim has to plead for charges to be filed, and express their relief when charges are filed, even though the driver is not charged with homicide. Still, Grohowski looked forward to at least some measure of justice for his daughter, and to moving forward with his own life, noting "[I've got to] Try to pull my life back together so I can start over again because that's what I have to do."
Six month's later, Grohowski's relief that his daughter would have justice turned to disbelief when the jury returned a verdict of not guilty on the hit and run charge. Moyer hung his head and cried as the verdict was read. The jury had been convinced by Moyer's defense that the distance he had traveled — 100 feet — after hitting Autumn and being forced to a halt, was too short a distance to be evidence beyond a reasonable doubt of hit and run.
There may have been more to the verdict than a good defense, though — there may also have been more than a touch of "there but for the grace of God go I" sympathy for Moyer. One anonymous person, while commenting on the news in an online forum, and claiming to be one of the jurors who heard the case, explained "Yes Moyer should have stopped at the train tracks, but people try to beat the train; we live in a fast-paced world. We run yellow/red lights, we run stop signs. It's a sad story that shouldn't have happened, but it did." That comment was not the only show of support in the community for Moyer; many of Moyer's partisans chimed in with their own support for Moyer, with one commenter observing "it was just a terrible, horrible accident that he has to live with - but is not his fault." Yes, Moyer's partisans reasoned, he was driving drunk, yes he blew through a railroad crossing as the warning lights were flashing and the safety arms were coming down, and yes, by doing so he killed a young woman — but her death was "not his fault." It was, the same Moyer partisan explained, "purely an accident."
The judge was decidedly more sober in his assessment of Moyer's actions that June night. Because the hit and run charge carries a penalty in excess of one year, Moyer was entitled to a jury trial on that charge. However, the other charges carry lesser penalties, so Moyer was not entitled to a jury verdict on those charges. Accordingly, once the jury cleared Moyer of the most serious charge, the Judge declared Moyer guilty on the remaining charges of DUI, careless driving, and not yielding to railroad warning signals.
Despite the convictions on the lesser charges, this was not the justice for Autumn that Kris Grohowski had so desperately wanted and anxiously waited for. Exiting the courtroom, Grohowski said "this is terrible," calling the jury's decision "a load of malarkey." Grohowski's only hope for bringing to justice the man who had ended his daughter's life now lay in the civil lawsuit he had by that time filed against Moyer.
After delivering his verdict, Judge John C. Tylwalk set a July sentencing date; Moyer faced a sentence of 72 hours to 6 months imprisonment on the DUI charge. Under Pennsylvania law, Moyer may also face a separate hearing, at which the Department of Transportation may seek to suspend his license for a 12-month period. But for killing Autumn Grohowski, Moyer would not do one minute of time.
On July 16, Judge Tylwalk sentenced Moyer to 2 to 6 months in County Prison. Moyer was also ordered to pay a $1,000 fine for drunken driving, and a $525 fine for careless driving and driving with an open container of alcohol in his vehicle. In addition to the fines, Moyer was also ordered to pay restitution of $1,375; Judge Tylwalk also prohibited Moyer from driving for the next six months.
Noting that the sentence could have been as light as 72 hours in jail, prosecutor Bob McAteer said that Judge Tylwalk "really put the hammer down" on Moyer. The Grohowski family saw things a little differently. "It's so unfair," Autumn's mother, Karen Gregorio, said. "He gets two months and she could have had 50 to 60 years. He got away with murder." Autumn's brother, Pennsylvania National Guard Staff Sergeant Kevin Grohowski, who told the Judge "I loved my sister; it's been devastating to me," described the sentence as "a slap on the wrist." Noting that her son had just completed one tour of duty in Iraq, and was scheduled to return to Iraq in February to begin a second tour, Karen Gregorio bitterly observed that "my son goes overseas to protect this guy's right to drink."
Moyer will serve his sentence, and then his life will go on. He will be prohibited from driving for the term of his sentence, and then, in its wisdom, the State of Pennsylvania will once more allow him to operate a motor vehicle. Moyer's life will go on.
Autumn's life will not. Nor will her father's. On May 29, three weeks after Gregory Moyer's trial, despairing at having failed to obtain justice for Autumn, and unable to endure his continuing grief, Kris Grohowski ended his own life with a gunshot. (
(Research and drafting provided by Rick Bernardi, J.D.)
I'd like to thank Shaba Mohseni and the San Luis Obispo County Bicycle Coalition for hosting me at their Pedal to the People Fundraiser on July 19. It was a great event, combined with some great racing, and a chance to see how they do things in San Luis Obispo. From my time there, it's obvious that San Luis Obispo has somehow managed to avoid the conflict between road users that plague other communities. I will be discussing that conflict, including the recent road rage incident in Brentwood, in my next column.
Until then, I'd like to extend my thanks to everybody who has contacted me to request my appearance at their event. I will be speaking as extensively on "Bicycling & the Law" this year as my practice will allow, and will make plans to appear before any club, bike shop, or other engagement that is interested in hosting me. If you would like me to appear to speak at your event or shop, or to your club or group, please drop me a line at firstname.lastname@example.com (and if you would like to contact me with a question or comment not related to my speaking tour, please drop me a line at firstname.lastname@example.com). I'm looking forward to meeting as many of my readers as possible this year.
This article, When Justice Fails, originally published on VeloNews on July 25, 2008.
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A Missouri woman who was convicted of three misdemeanors related to the MySpace harassment of a teenager who committed suicide will likely face probation and a $5,000 fine, according to a report.
The attorney for Lori Drew filed a pre-sentence report urging the court to go with probation and a fine. Furthermore, her lawyer, H. Dean Steward, also wants the convictions to be dismissed. Steward said MySpace wasn't to blame, and the girl's alleged history of mental illness and bouts of depression were more to blame than anything else.
Drew reportedly created a fake MySpace account posing as a teenage boy and sent flirtatious messages to Megan Meier, one of her neighbors. Shortly after, the fictitious teenage boy dumped Megan while also saying the world wouldn't miss her. The girl hanged herself after reading the messages sent through MySpace.
After originally being convicted last November, Drew faces three years in jail and a fine up to $300,000 related to the three misdemeanor counts of accessing computers without authorization. She originally was charged with four felony counts, though she was cleared of three of them and the jury was deadlocked on the final felony count.
"This is about justice," Megan's mother said after the verdict. "It's justice not only for Megan but it's justice for everybody who has had to go through this with the computer and being harassed."
Drew reportedly can't pay the $5,000 fine since she lost her job when she stopped working in November 2007. In addition, several neighbors have harassed and threatened her, leading up to a brick being thrown through one of her windows. The family eventually had to move out of the neighborhood.
She is expected to be sentenced on May 18, and Steward has asked that Megan's friends and family not speak at the sentencing, as it's "still a computer fraud case."
quote: No she didn't. Pushing is an act of physical violence, and the mother committed no physical trespass against the girl who killed herself. She may have done emotionally malicious and hurtful things, but at the end of the day, she played no tangible part in the girl's decision to kill herself, or in the physical act of carrying out that decision. She's not liable for the girl's death, and to assert otherwise is borderline ridiculous.
quote: Ultimately, I made the decision to take my own life, and no matter what reasons I might cite, or who I might try to blame, the responsibility for that decision is my own, and no-one else's.


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Published August 18, 2014
Children attending the UB Child Care Center's summer camp last week learned about the importance of water to everyday life as part of an annual summer program presented by the Office of Sustainability.
Twenty children between the ages of 5 and 9 — most the sons and daughters of UB employees and students — made their way to Lake LaSalle on the North Campus to hear a talk about the role of water to all living things and the dangers of pollution.
The children used bowls of water and food dye to learn about pollution and how plants absorb water. They also looked through microscopes to examine samples of water taken from Lake LaSalle to see what microorganisms are present in the pond.
This is the third consecutive summer the Office of Sustainability has partnered with the UB Child Care Center to offer programming. Last year, children visited Letchworth Woods near the Ellicott Complex, where they learned about forest habitat — "the focus was on creating a personal connection to place," says Erin Moscati, sustainability education manager in the Office of Sustainability. The previous year, campers visited UB's Solar Strand to learn about renewable energy.
The goal of the programming is to expose the children to sustainable concepts, raise awareness and promote UB's sustainable initiatives, Moscati explains.
"This is a great way to reach members of the UB community we may not typically interact with and demonstrates our commitment to creating a sustainable culture," she says.


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Some charmed, some inspired and some simply made us laugh. Take a look at the most influential animals of 2013.
For the first time in more than three decades, scientists discovered a new mammal in the Americas. Native to Ecuador and Colombia, the cute, fluffy olinguito officially became the smallest member of the raccoon family when the Smithsonian announced the discovery in August.
President Obama officially introduced the one-year-old pup, Sunny, on Twitter in August. She joined fellow Portuguese water dog Bo, who until then had been the Obamas' only pooch.
Therapy dogs in Boston and Newtown
A pack of five golden retrievers arrived in Boston to offer comfort to the community following the Boston Marathon bombings in April. The pups were part of the nonprofit K-9 Comfort Dogs, These comforting canines had also spent time in Newtown, Connecticut, offering support to the community following the tragic shooting at Sandy Hook Elementary School.
The Cicada invasion that wasn't
New York City (and other parts of the East Coast) was in for a major cicada invasion in June, but it fell short. The invasion, which comes once every 17 years, did happen in some areas, but in the end it was all very underwhelming.
Bowser, the rescued tornado dog
During an on-air interview with CBS News, Moore, Okla. resident and tornado victim Barbara Garcia described how the tornado tore apart her home and how her dig was trapped somewhere beneath the wreckage. Suddenly, someone off-camera discovered that Garcia's dog, Bowser, was buried alive beneath the rubble. Garcia and the news crew managed to lift the debris and rescue the pup.
Washington Zoo pandas
When the U.S. government shut down for two weeks in October, the National Zoo pulled the plug on its beloved panda cam. When the live feed went dark, the Internet rebelled. After the two-week deprivation, the Internet breathed a collective sigh of relief when the zoo shared a very important message on Twitter: "The panda cam is back ON!"
Rescued "gay" shelter dog
A pit bull in Tennessee ended up at an overcrowded kill-shelter because his owner, after seeing the dog mount another male pooch, thought he was gay. A Facebook post in the dog's defense was shared more than 5,000 times and a local veterinary technician came forward, agreed to adopt him and saved him from being euthanized.
Gowanus dolphin
A dolphin arrived in Brooklyn's Gowanus Canal in January. The aging dolphin died in the dirty waterway causing many to worry that the Gowanus led to its end and spotlighting the canal's filthy state. It was later proven that the dolphin was very sick before swimming into the canal.
Grumpy Cat
This one-year-old feline's perpetually frowning face turned her into a massive online sensation over the past year. Her cat empire is now worth an estimated $1 million and includes a coffee line, a New York Times-bestselling book and even a movie deal.
This former stray dog has become the first canine on record to climb Mount Everest after trekking for 10 days with the owner who rescued him to base camp, 17,000 feet above sea level.
Chris P. Bacon
This piglet, who became an instant internet sensation, was born without the use of his hind legs and began learning to walk with the help of a pint-sized wheelchair made from toy parts. The video of the piglet using the wheelchair racked up more than 1.5 million views
To read more about the most influential animals of 2013, click here.
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|Enzyme Structure Provides Insights into Cancer and Aging
XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws—as seemingly insignificant as a change in either of two adjacent amino acid residues—can lead to diseases with completely different physical manifestations.
Using data collected at the SIBYLS Beamline 12.3.1, the researchers solved the crystal structure of XPD from Sulfolobus acidocaldarius. The data show that the catalytic core of XPD has four domains: two helicase domains named HD1 and HD2, an Arch domain, and an iron–sulfur cluster domain (4FeS). The Arch and 4FeS domains are insertions into the linear sequence of the HD1 domain, and these domains all lie in the same plane and form a flat, pentagonal-shaped box with a small hole. In the researchers' proposed model, DNA is unwound as it travels through the hole formed between the HD1, Arch, and 4FeS domains. HD2 protrudes from the box to form long channels between itself and the other three domains. These channels, according to the model, bind single-stranded DNA and ATP.
Twenty-six single amino-acid changes in XPD can cause disease in humans. The position of each mutation along the linear sequence of XPD does not predict the large differences between XP, XP/CS, and TTD. In fact, even mutations in adjacent amino acids cause different diseases. By combining structural analyses of the wild-type protein with biochemical measurements of XPD mutant enzyme activities, the researchers now have a detailed molecular framework that begins to explain why a mutation at one amino acid leads to XP rather than XP/CS or TTD. Since XP mutations cluster along the DNA- and ATP-binding channels, they decrease helicase activity. Besides losing helicase activity as expected for XP mutations, XP/CS mutations also replace small flexible amino acids with larger ones, reducing flexibility. These mutations are largely found at the HD1–HD2 interface and therefore affect the conformational crosstalk between these domains to impact DNA-binding activity or potentially interactions with partner proteins. TTD mutations are found throughout the protein and disrupt stabilizing interactions between amino-acid side chains and/or protein main chains. These changes disrupt the framework of the XPD protein to reduce its structural integrity.
How do these changes in the XPD protein structure determine a patient's fate? Based upon XPD structural biochemistry, the researchers predict that an XP patient has reduced DNA repair capacity and therefore cannot repair all of the damage that occurs on sunlight-exposed areas of the skin. XP/CS patients have the same cancer susceptibility as XP patients with the added complication of a mutation that reduces XPD flexibility. This compromises the cell's ability to survive, leading to premature aging. TTD seems to work in an equal, but essentially opposite way. Instead of decreasing flexibility, TTD mutations increase protein flexibility, which likely disrupt the interactions of XPD with other proteins. These combined structural and biochemical results broaden our understanding of how XPD structural changes might have an impact on cancer or premature aging. Significantly, these results reveal the importance of the overall and detailed three-dimensional structure as well as the active site and interfaces in biological function.
Research conducted by L. Fan and A.S. Arvai, (The Scripps Research Institute); J.O. Fuss, Q.J. Cheng, M. Hammel, and P.K. Cooper (Berkeley Lab); V.A. Roberts (University of California, San Diego), and J.A. Tainer (The Scripps Research Institute and Berkeley Lab).
Research funding: National Institutes of Heath. Operation of the ALS is supported by the U.S. Department of Energy, Office of Basic Energy Sciences.
Publication about this research: L. Fan, J.O. Fuss, Q.J. Cheng, A.S. Arvai, M. Hammel, V.A. Roberts, P.K. Cooper, and J.A. Tainer, "XPD helicase structures and activities: Insights into the cancer and aging phenotypes from XPD mutations," Cell 133, 789 (2008).
ALSNews Vol. 295, February 25, 2009
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River in western Beleriand, which runs close to Nargothrond. It provided a natural defence for this city against the forces of Morgoth, which mostly fear water. That is, until Turin foolishly advised the elves to build a bridge, which provided a handy access route for Glaurung...
It's featured in Tolkien's book The Silmarillion - see the map at the back for exact details of where it goes.
dodane przez Andy maj 11, 2004
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CRYSTAL BAY, Nev. - It's easy to bang your head when you have long hair.
From the creators of the Boogie Knights, The M-80s and The Spazmatics, comes PWE Productions' Metal Shop - an outrageous spoof of 1980s heavy metal music featuring some of the best musicians in the LA music scene. The band rocks a free show in the Crystal Bay Casino Crown Room at 9 p.m. Saturday, Dec. 8.
Although often referred to as a "band," the Metal Shop show is actually the brainchild of producers Jamie Brown and Roger Sause, who pick the cast members, perform, sing and produce the backing tracks, and direct in costuming, choreography, scripted comedy and other "schtick."
Since its debut in 1997, Brown and Sause have expanded the Metal Shop show (also performed under the alter ego of "Danger Kitty") into eight different lineups spread all throughout the country annually performing hundreds of shows.
Often copied, but never equaled, the Metal Shop show has been pirated by many wannabes who are, in effect, paying tribute to another tribute act, a press statement claimed, adding that the band is younger, taller, skinnier, and funnier than ever.


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Ashley Olsen Gossip
Ashley Olsen gossip, latest news, photos, and video.
Twin Romances
I totally forgot that Ashley Olsen is dating director Bennett Miller. You know his work: Capote, Moneyball, and the upcoming Foxcatcher for which he's predicted to earn an Oscar nomination. They've already honoured him with a Best Director Award earlier this year in Cannes. Imagine? Bennett Miller at the Oscars with Ashley Olsen? Miller is 47 years old. Full Story
OMG. A kitten on a twin
Larry Busacca/ Dimitrios Kambouris/ D Dipasupil/ Getty
Mary-Kate and Ashley Olsen won Accessories of the Year for The Row last night at the CFDAs. I love The Row. I love them. But… Look at Ashley's feet. It's a kitten heel. A f-cking kitten heel. There is no love here at LaineyGossip for the kitten heel. Supposedly the fashion people are trying to make it happen. Full Story
All of them: MET Olsens
Dimitrios Kambouris/ Larry Busacca/ Rob Kim/ Getty
Elizabeth Olsen has the acting career. But her sisters know the fashion. Clearly she didn't ask them for their advice. WHAT THE F-CK is happening here? Yes, as many of you have already observed, this is figure skating. And not even now figure skating but 1990s figure skating. It's also Miu Miu. Full Story
Birthday Twinsies!
Mary-Kate and Ashley Olsen are 27 years old today. To celebrate their birthday, they wore... matching ... What do you call these, anyway? Sport sandals? These two have made it a point not to dress similarly for years. And we're not supposed to call them the Olsen twins anymore either. Full Story
Worst MET Sisters: Mary-Kate & Ashley Olsen
Dimitrios Kambouris/ Larry Busacca/ Getty
These two. And I'm usually an Olsen apologist. But Ashley totally missed the point here and you'd think Mary-Kate would embrace the punk but instead both of them seemed to be under the impression that the MET Gala theme this year was Shades of the Orient. What's frustrating is that MK was almost there. Full Story
Ashley and her sister's boyfriend
DAVID KRIEGER/ bauergriffinonline.com, Sharpshooter Images/ Splash
Mary Kate Olsen is dating Olivier Sarkozy. They've reportedly moved in together. On Saturday they had brunch with her sister Ashley who, at first glance, looks like she has freakishly small arms in that coat. Full Story
Was it the alligator backpack?
Wenn, Larry Busacca/Theo Wargo/Getty
Mary-Kate and Ashley Olsen were named Womenswear Designer Of The Year last night for The Row at the CFDA Awards in New York. Was is that alligator backpack that retails for $34,000? This is not a typo. Click here if you want to buy it. In selecting the Row and MK and Ashley as the award recipients, does that mean we must believe that they actually do the sketching? Please Fashion People, tell me how and what to think. Full Story
Johnny or Jared?
Fame/Flynet, Jackson Lee/Splash
A couple of weeks ago, In Touch reported that Johnny Depp was spotted sneaking out of Ashley Olsen's apartment in NYC on February 27th after having spent the night there. Click here for a refresher. Since it's In Touch, and therefore salt-grainy, that story came and went pretty quickly. Full Story
Johnny Depp & an Olsen Twin
WHAT?Normally I wouldn't cover this story. But I know you'll be pounding me with emails this all day. As I always say though, please, please, PLEASE, before you get excited about gossip, any gossip, please, please, PLEASE consider the source.The source is IN TOUCH WEEKLY.In Touch Weekly keeps saying that Katie Holmes is leaving Tom Cruise. Full Story
Is this Justin's girlfriend?
Everyone is all over this Ashley Olsen/Justin Timberlake situation. Click here if you missed my initial thoughts about it earlier this week. During the liveblogs, people have been asking whether or not it's legit. My thoughts? Well first, I hear they've been out in a group several times in NYC with friends, including her sister. Full Story
Pippy's Most Significant
Spoken like a man who just dumped a girl... I don't always have kind things to say about Justin Timberlake, and this might be a backhanded compliment but after he f-cks up a girl, at least he's speaks well of them. Including the most recent Jessica Biel. In his new interview with Vanity Fair, here's how he described the Shelfy: "She is the single-handedly most significant person in my life. Full Story


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Lockheed Martin is moving 560 jobs from Marietta, Ga. to Fort Worth
The employee group has been building the F-22 Raptor advanced stealth fighter jet fleet. Now they'll be supporting the aircraft.
The move had been under consideration for some time.
In addition to providing support for the F-22 Raptors purchased by the U.S. Air Force, the staff will "look for opportunities to make improvements to the aircraft," said Lockheed spokesman Joe Stout.
Lockheed delivered the aircraft to the Air Force in May and the jets are expected to be in service for 20 to 25 years. The company produced 195 F-22 Raptor jets at a cost of $147 million each.
Lockheed Martin continues to produce F-16 Fighting Falcons for other countries and will continue to do that "at a low level" from the Fort Worth plant for several more years, Stout said. That work has evolved into a support business that includes making modifications to and updating the F-16.
So it makes sense to consolidate all support work to Fort Worth, Stout said.
Marietta employees affected include engineers, schedulers and administrative staffers and have until Jan. 7 to decide if they plan to move. The consolidation is expected to be completed by March.
Marietta will continue to manufacture the large cargo aircraft like the C-130 Hercules, Stout said.
Lockheed has about 14,200 employees in Fort Worth.


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Stonz Booties, Fleece Liners$19.99
Stonz Booties ... a must have for rain, slush or snow.
Stonz Booties stay on securely, slip on easily over other clothing, and protect little feet and dangling ankle from inclement weather. Stonz Booties are versatile enough to be worn both outdoors and indoors throughout several weather seasons. Perfect for the rain, slush or snow, Stonz booties are the most versatile rain and snow boot you'll find!
In spring and autumn slip Stonz Booties easily over pants, sleepers, socks and even soft-soled shoes. The come equipped with a light fleecy liner, so no additional inserts are required. For colder winters, add Stonz Sherpa-Fleece Liners for extra warmth to keeps your little ones toes warm.
Water-repellant and wind-resistant Stonz Booties are sized generously for an adjustable fit and flexible construction, children can often wear the same size throughout the year.
Why parents love Stonz Booties:
- Water-resistant nylon upper, fleece lining and rubberized soles.
- Soft-soled boots for children are perfect for early walkers!
- Sherpa-fleece Linerz can be inserted for extra layer of warmth.
- Incredibly light-weight, these are much more comfortable for parents carrying their little ones to and from the car.
- Flexible design and adjustable fit allows for extended wear as child grows.
- Layer them up or down for use throughout Fall, Winter, Spring + Summer.
- Two adjustable toggles ensure they stay on.
- Wide opening ideal for chubby feet and ankles.
- Soft, skid-resistant soles recommended for developing feet.
- Machine wash & dry, inside out on delicate.
- Canadian Podiatric Medical Association Seal of Approval.
Made in China by Canadian company Stonz Wear.
Fleece liners (inserts) sold separately.
Customer Reviews
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Easy to get on, warm and functional! Review by Angela
Value Quality Price
I have owned a couple pairs of the stonz booties for my daughters. I loved them ! They kept their feet warm and dry. I also used the fleece insert which I would highly recommend if you live in a colder climate. My daughters had a hard time pulling them off which was a bonus for me! I have also purchased several pairs as gifts and will continue to use this as a go to gift idea! (Posted on 11/6/13)Would you recommend this product to a friend? Without hesitation!


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INCLINE VILLAGE, Nev. — Craig Fellin, "Marlboro Man," owns and runs the Big Hole River Outfitters Lodge in Montana, and at 65, knows every little hole in that Big Hole River. Tonight he has kicked over some logs on the river's shore, made note of the insects that are hatching, and is tying flies to prepare a picture perfect breakfast for a German Brown.
To watch Marlboro Man fly fish is like watching James Marshall gazing into the waters of the American River. He sees a living gold sliver shimmering in the shadows where nobody else sees it, and that living gold is going to be his for one precious moment, before tossing it gently back into the shallows. Each new dawn for Marlboro Man is like a dawn at Sutter's Mill, and it's always the first time with him; he never tires of it and never will.
Then there's Ginzo. When Ginzo arrives at the Big Hole Lodge you can hear the fish chuckling in the stream. "Hey, Guys ... Ginzo's back ... we're safe for the rest of the week!"
When Ginzo wades into the Wise on those slippery rocks it is not like watching Jesus walking on water, but the opposite. The trout gather 'round, and prop themselves up on the rocks to watch. Upon Ginzo's first misstep they start to grin, upon his second, where his pole goes airborne, they begin to snicker, and when he finally succumbs and goes under, well, they nearly drown themselves with laughter. As a matter of record, the only thing Ginzo would catch in a week of fishing would be Marlboro Man's vest upon his first cast.
But the good news is, mosquitoes take no interest in Ginzo whatsoever, for he drinks so much cheap whiskey and smokes so many cheap cigars, and swears so loud that everybody in his immediate company is safe from mosquitoes. And his swearing is not of the common variety, no, just when you think he's got a perfect ripper going, he shovels in an expletive of his own making that feels like a shoe that is one size too large.
Marlboro Man, on the other hand, can swear like Barbra Streisand can sing. He brings the blue jays out of the trees and they land on his shoulders when he swears. His cursing is a symphony to anybody who has the pleasure of hearing it, and I don't imagine there is anything quite so calming in all of God's green acre.
So what are these two malaprops doing fishing together? Well, there was another river, in another time, in Quang Tri Province, when they paused in the current while crossing, to stand in awe of the schools of fish surrounding them. Marlboro Man lit-up a cigarette, turned to Ginzo and said, "Ginz, if we get out of here alive, we're going fishing in Montana and have ourselves one-merry-hell of a holiday."
So that's just what they did this past week, 46 years later. They went fly fishing on the Big Hole River. The trout, meanwhile, contented themselves in watching them drift by in their little dingy, smoking cigars, sipping whiskey, and sharing stories that may or may not have ever happened.
— Learn more about McAvoy Layne at www.ghostoftwain.org.


text: Maureen Howard deepens her inquiry into the meeting place of history and family in this stunning and accessible novel. Isabel Murphy renounced silent-film stardom to raise a family in Rhode Island. Now she is dead at 90 and her children are trying to break free of the lives she has dealt them. Joe, a Jesuit priest, has failed at love and the healing of souls. Stodgy Rita has found late happiness with a gangster who has turned state's evidence. And Gemma, Isabel's honorary child, has grown up to experience a strange celebrity as a photographer. A darkly comic story of guilt, love, and forgiveness, The Silver Screen is luminous in its intelligence and empathy.


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Nyko 87095 Wii Wand+ - Full Motion Technology, Rumble Support, Trans-port TechnologyItem#: NY10-2088 | Model#: 87095
Currently Out Of Stock!
Nyko 87095 Wii Wand+ Product Details
Nyko 87095 Wii Wand+
Experience the most advanced Wii Remote alternative in the world with the Nyko 87095 Wii Wand+. The Nyko 87095 Wii Wand+ allows for complete control of all compatible Wii software and menus and features full accelerometer control support, vibration feedback, and built-in speaker as well as Nykos new Full Motion Technology. Full Motion Technology provides 1:1 movement tracking fully compatible with all Wii Motion Plus games without the need for any extra dongles or add-ons. With the Wand in your hand, youll have total control of all your Wii software as well as a rubberized B-Trigger, larger 1 and 2 buttons and an improved and re-worked d-pad for more comfortable and accurate classic and horizontal game play. The Wand is ergonomically crafted for left and right handed use with a form factor designed for maximum compatibility with 1st and 3rd party accessories. Expand your control possibilities with Nykos Trans-Port Technologies, exclusively developed for the Wand. Trans-Port Technology allows specially designed attachments to pass through key buttons to the attachment, allowing for more responsive attachments that can easily integrate with your Wand controller for a variety of games.
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Manufactured by: Nyko
Warranty provided by: Nyko
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Mfg Part No: 87095
Box Size:
( Length:0, Width:0, Depth:0)
Shipping Weight: 1.0000 pound(s)
Click here for full warranty and support information
- Nyko logos are registered trademarks of Nyko. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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Collection: 0001 Swatch Batch
Mostly digital art/all originals - do not copy (Copyright Pamela Rinehart - all rights reserved) | YES - you can make/sell anything made with fabric you buy | view fabric collections for a better experience
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Click "GLIMMERICKS" above to visit my shop. Visit http://www.glimmericks.com/fabric-collections.html for an organized list of my collections.
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LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
Scientists at University of Michigan Medical School think they may be on to finally answering questions such as what makes a person bipolar and why does bipolar disorder run so strongly in families, even though no single gene is to blame?
The researchers report that they used skin from people with bipolar disorder to derive the first-ever stem cell lines specific to the condition. In a new paper ("Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients") in Translational Psychiatry, they describe how they transformed the stem cells into neurons similar to those found in the brain and compared them to cells derived from people without bipolar disorder.
The comparison revealed specific differences in how these neurons behave and communicate with each other, and identified striking differences in how the neurons respond to lithium, the most common treatment for bipolar disorder. It's the first time scientists have directly measured differences in brain cell formation and function between people with bipolar disorder and those without.
Using induced pluripotent stem cells (iPSCs), the team exposed them to carefully controlled conditions and coaxed them to turn into stem cells that held the potential to become any type of cell, including neurons
"We have examined changes in gene expression as iPSCs derived from well-characterized patients differentiate into neurons; there was little difference in the transcriptome of iPSCs, but BP [bipolar] neurons were significantly different than controls in their transcriptional profile," wrote the investigators. "Expression of transcripts for membrane-bound receptors and ion channels was significantly increased in BP-derived neurons compared with controls, and we found that lithium pretreatment of BP neurons significantly altered their calcium transient and wave amplitude. The expression of transcription factors involved in the specification of telencephalic neuronal identity was also altered."
"This gives us a model that we can use to examine how cells behave as they develop into neurons. Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how they differentiate into neurons, how they communicate, and how they respond to lithium," said Sue O'Shea, Ph.D., the U-M stem cell specialist who co-led the work.
"We're very excited about these findings. But we're only just beginning to understand what we can do with these cells to help answer the many unanswered questions in bipolar disorder's origins and treatment," added Melvin McInnis, M.D., principal investigator of the Prechter Bipolar Research Fund and its programs. "For instance, we can now envision being able to test new drug candidates in these cells, to screen possible medications proactively instead of having to discover them fortuitously."
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text: My Dad is a 92-year-old World War II veteran, former professional athlete, and my hero. After pitching for the New York Yankees and Philadelphia Phillies, he had a successful career in the aircraft business and enjoyed collecting as a hobby. And to my mother's dismay, collect he did. My father saw the beauty and value in many diverse objects. From antique tools and weaponry to sports collectibles and athletic gear, my Dad loved it all. He always had the most interesting things, even if it wasn't neat enough for my mother's taste. My audiences have probably heard me say that my favorite place in the world is my father's garage-filled with cool stuff. So, as Father's Day approaches, I want to dedicate this column to the men who, like my Dad, enjoy collecting for collecting's sake.


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A stealth form of male masturbation performed while wearing pants, typically in a semi-public setting such as a movie theater or while driving. In order to sidehack a man must first position his penis along his inner thigh. He will them stimulate the penis by rubbing or stroking his inside thigh through his pants.
You see that hot chick at the bar last night?
Yeah, I was sidehacking it the whole way home.
Yeah, I was sidehacking it the whole way home.
sidehacker tərəfindən 02 Oktyabr 2006
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