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Cracking the Dress Code
When Truman Capote sent out invitations for his Black & White ball in 1966, he left nothing to chance. The writer gave his guests specific instructions: Gentlemen: Black Tie, black mask. Ladies: black or white dress, white mask, fan. Almost 50 years later, the converging line between party dress codes can cause a type of panic last seen in New York society after Capote's invitations were delivered.
Before a recent dinner party in London, I called to check the dress code. As an American, I took the Italian hostess's simple reply of "Jackets, no tie" to mean the evening would be a casual affair, akin to a barbecue at the local country club, perhaps. "Oh, you are very wrong," my British husband replied. "When Europeans say 'Jackets, No Tie,' it means you really have to dress up." Sure enough, the women wore vertiginous Louboutins and diaphanous chiffon dresses (despite the cold) and the men, impeccably cut blue blazers with velvet slippers that bore their family crests.
Dress codes were invented to give clear sartorial direction, but these days, it can be anyone's guess. Good for rule breakers, not so much for the rest of us. Men, in particular, can have a tough time. "Men hate having to break from the norm," says Emma Willis, who started her eponymous bespoke shirt label in 1987 and has spent the past 26 years holding many a client's hand as they navigate the Dos and Don'ts of parties. "There was even an incident of a man being thrown out of a club because he wore a tie. No wonder everyone is nervous."
Hosts, conscious of their guests' quandary, are finding creative ways to take fear out of the equation. "I was once sent an invitation to a party in California that actually included two sketches of possible outfits," says Julian Vogel, director of fashion and beauty PR firm Modus Publicity. "I was so relieved."
So how do you tell your Glamorous from your Garden Party? Use our code cracker.
Jacket No Tie
The most laid back of the social-circuit rules, Jacket No Tie is code for "show off your beautifully tailored wardrobe."
"For me, this means a proper collared shirt, or even smart polo shirt, trousers and a navy single- or double-breasted blazer—mine are made by the Roman tailor Caraceni or Anderson & Sheppard," says Italian businessman Massimo Carello, who also sports slippers from G.J. Cleverley. "Jacket No Tie allows men coming directly from work to remove their tie and unbutton their shirts without feeling out of place."
For Frenchman Edouard de Boisgelin, an investor and entrepreneur in London, Jacket No Tie means denim is OK. "The only time I change out of my jeans is when the invitation specifically says 'no jeans,' " says Mr. de Boisgelin, who owns 20 pairs of Earnest Sewns. "Otherwise, for me, it's a white shirt—I have them made by Favourbrook—jeans and moccasins. I like the Christian Louboutin Rollerball spiked loafers." He also wears mismatched velvet slippers—one depicting an embroidered screw, the other the letter U in red—by Stubbs & Wootton. Recently, he has added to those footwear flourishes by mixing cardinal red with bishop purple socks from Gammarelli in Rome, suppliers to the Vatican. Though Mr. de Boisgelin admits to occasionally feeling underdressed, he says he makes up for it by wearing extra-long cashmere scarves.
"For an Englishman, Jacket No Tie means a double-breasted blue blazer and perhaps gray flannel trousers and a crisp white shirt," says Audie Charles, of Savile Row tailors Anderson & Sheppard. "And I mean crisp. If it's not, send it to the laundry."
Lounge Suit
A step up from No Tie, Lounge Suit is really just business suits, jazzed up to sound like it will be a fun evening. It is often accompanied by Cocktail Dress for women. "Lounge suits are normal business suits, worn for semiformal occasions with a shirt and tie—unless No Tie is specified," says Ms. Willis. "So the trousers and jacket must match."
But like most dress codes, there is some room for interpretation. For Mr. Carello, Lounge Suit is "a code name to say you can come straight from work." That means a double- or singled-breasted suit from Anderson & Sheppard.
Mr. de Boisgelin, however, eschews the norm. "A lounge suit is what you wear to a funeral or when invited to dinner with someone's parents," he says. "This is the only occasion in which I will wear a tie."
Black Tie
Nothing splits the male community more than the definition of Black Tie. For some, it is a sacred uniform; for others, it's just a color guide.
"I was recently invited to the Men of the Year awards in which the host, Dylan Jones, editor of GQ, specified 'Black Tie, not Fashion Black Tie,'" says Mr. Vogel. "It has become fashionable—specifically at events like the Oscars—for men to don a textured Calvin Klein suit with a Gucci black shirt and a very thin tie, rather than a traditional black tie," he says. "Edgier men prefer the modern labels like Rake Lounge to traditional black tie."
Traditionalists, however, tend to think of Clark Gable or even James Bond when they see Black Tie on an invite. "This new trend of wearing dinner suits with black shirts makes everyone look like a gangster," says Ms. Charles. "It's not 'The Sopranos.'"
A formal Black Tie dress code means a black wool suit with contrasting silk lapels and ribbon down the outer seam of the trousers. It should be paired with a white bib-front shirt and a silk bow tie. Waistcoat and cummerbund are optional, but the color is not. Shoes and socks are also always black.
But once the band gets going, new rules apply. "Evening shirts used to have voile sleeves and backs to keep the partying man cool and fresh throughout the evening," says Ms. Willis. "But now, men just take off their coats, ties and roll up their sleeves to hit the dance floor."
Well, most men. "I will not remove my bow tie until I am in the car on the way home," says Mr. Carello. "The only room for maneuver in Black Tie is the choice of silk handkerchief."
For women, this is simple: Wear your highest heels, your most fabulous jewelry and that little or long black dress. Blow dries and manicures go without saying.
For men, it's a bit harder. Glamorous, or Dress Up, technically means neither Lounge Suit nor Black Tie. It can be code for "dress cool," allowing men to don edgier Savile Row labels like Richard James and Spencer Hart without looking like they are trying to be David Gandy or David Beckham.
'This new trend of wearing dinner suits with black shirts makes everyone look like a gangster. It's not 'The Sopranos.''
Or it can be a cue to get the maddest jacket out of your closet—all the better if it was handed down by your grandfather. "Either go adventurous and have a party shirt made, or don a Nehru velvet jacket," says Ms. Willis. "I recently made a shirt for a man who came in distraught because the dress code was Romantic," she adds. "It was fine white cotton, with full gathered sleeves and a deep, four-button cuff. The collar was a high band with a white cotton sash tied in a big flamboyant bow at the neck. A full shirt, then all nipped in with tight black trousers and a big black leather belt with a heavy silver buckle."
A cautionary note for Brits abroad: Fancy Dress may mean "costume" in the U.K., but in the U.S., it means Black Tie. Check with the host before improvising on this one.
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What do you think of the new TARDIS interior?
i don't love it, i don't hate it. i'm glad it still has some similarities to the last TARDIS (in shape/organicness and color scheme). Looks like we may get more on-board footage!

subset: commoncrawl


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"I'm just one of the fun guys here."
March 9, 2011
Rick is looking for new friends and talks about 3 of his recent documentaries with PITTSBURGH in their titles: WHAT MAKES PITTSBURGH PITTSBURGH?, UNDERGROUND PITTSBURGH and INVENTED, ENGINEERED & PIONEERED IN PITTSBURGH. Get all 3 shows on DVDs for a $60 membership at WQED!


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SALEM- Investigators were out in force Friday searching along state Route 45 for evidence in connection with Monday's assault that left Melinda Todd dead and her young grandson severely injured.
About 20 police officers and sheriff's deputies who are members of the Columbiana County Homicide Task Force searched both sides of Route 45, from Todd's home on Salmar Drive south to the bottom of the Ski Slope. The search was conducted from 10 a.m. to 2 p.m.
County Sheriff Ray Stone declined to say what they were looking for or if anything relevant to the case was found. "We searched the area to make sure we didn't miss anything," he said.
Article Photos
Morning Journal/Patti Schaeffer
A cold rain didn't appear to hamper a highly-visible evidence search by members of the Columbiana County Homicide Task Force along state Route 45 on Friday.
Todd, 43, was found dead Monday at her Salem Township home by her two daughters after they arrived home from school. Her 5-year-old grandson, Cole Reed, also sustained major head injuries and underwent brain surgery at Akron Children's Hospital. He regained consciousness and was interviewed by investigators on Thursday.
Officials have declined to say how Todd was killed or Reed was injured, but the boy's grandfather has said he was shot in the head. The county coroner's office has yet to issue a preliminary ruling in the case.
In addition to searching along Route 45 and around the Salmar Drive property, Stone said task force officers spent Friday interviewing people who may have information about the case.
This was the first time the county homicide task force has been used since it was created earlier this year. Participating police departments voluntarily assign an officer to the task force, providing a pool of investigators that any department can call upon for assistance when a homicide occurs in its jurisdiction.
The idea behind the task force is to provide enough manpower to help with the investigation during the first several days, which are often the most critical. The chief law enforcement officer for the community where the homicide occurs retains jurisdiction over the probe.
In this instance, the case is within the jurisdiction of the sheriff's office, and Stone said the task force has provided tremendous assistance to his four detectives.
"It has worked out pretty good. It's really helped out," he said.
Assisting Friday were officers from Salem, Columbiana, St. Clair Township, East Palestine, troopers from the Ohio Highway Patrol and the Salem Township constable. Other departments have sent officers at other stages of the investigation, in addition to the Ohio Bureau of Criminal Identification and Investigation.
"They've all sent different officers and have worked out great. I'd rather have too many (investigators) than too few," he said.


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If you're looking for a bright spot in the Cleveland Browns' 24-14 loss to the Philadelphia Eagles last Thursday, you got it from Michael Vick.
After taking a knee to end the first half, the Eagles quarterback went up to Browns rookie defensive tackle Phil Taylor and gave him a congratulatory pat on the back for his impressive performance.
Taylor wasn't as kind to Vick in the first half. The first-round draft choice sacked Vick, forcing a fumble that was recovered by Jayme Mitchell. There were other times when Taylor beat the blocking of guard Danny Watkins and center Jason Kelce to harass Vick.
The Browns thought Taylor could wreck inside havoc when they drafted him 21st overall. He flashed a few signs of promise in the first two preseason games, but he was dominant against the Eagles.
It wasn't as easy for fellow rookie Jabaal Sheard, who's in line to start at right defensive end. Sheard managed to get some pressure on Vick, but his run defense obviously needs plenty of work.
On a second-and-long situation Sheard was thinking pass and only pass. Lining up wide of the left tackle, he came off the edge hard and fast, only to watch Ronnie Brown run inside of him for a 13-yard touchdown.
Sheard is the classic speed pass rusher. He's not big, which means he can be pushed around by some 320-pound tackles. When a player gives up that much weight on run defense, he needs to use savvy and speed to win the battle. Sheard is geared too much to pressure the quarterback, often at the expense of his run play.
Overall it wasn't a bad night for the defense, despite the score. The Eagles didn't get their initial first down until almost the 6-minute mark of the second quarter. Vick scored on an 8-yard run, but he was kept in check as well as could be expected.
The show on offense was another matter for the Browns. Everything that went well in the first two games seemed to go bad against a defense that was able to get pressure on quarterback Colt McCoy.
The biggest concern at this time isn't with McCoy. It's the right side of the line, and tackle Tony Pashos in particular. Pashos was penalized once for illegal procedure and could have had more calls as he constantly tried to beat the snap count.
Pashos also looks slow and off balance in his pass drops. He was penalized for holding on a play when he put a bear hug on a defender to keep him from getting close to McCoy.
Penalties, an interception thrown by McCoy and other variables kept the first-team offense off the scoreboard. McCoy finished 9-of-18 for 81 yards and a passer rating of 41.2, but he was handcuffed by the aforementioned penalties and occasional breakdowns in protection.
McCoy threw a perfect deep sideline pass to tight end Evan Moore, who had the ball go off his hands. Since the defender had crossed under Moore in an attempt for an interception, Moore would have had a big gain had he maintained possession.
McCoy also threw a good deep pass to Brian Robiskie, who made the catch near the Eagles' 10. The play was nullified because of a pass interference call on Robiskie.
It was encouraging to see activity out of Robiskie, who caught three passes for 23 yards. Robiskie could be on the bubble. In two seasons he has 36 receptions for 416 yards and three touchdowns, numbers that aren't what coaches want from a high second-round draft pick.
Robiskie was picked when former coach Eric Mangini made all the personnel calls, which means general manager Tom Heckert probably doesn't have much loyalty for him. Rookie Greg Little is certain to make the roster, and Heckert hasn't concealed his admiration for Jordan Norwood, which could put Robiskie on shaky ground.
The Browns came up far short in a game that's referred to as the dress rehearsal for the regular season. The good news is that there were signs of promise (Taylor for sure), and the schedule is easier than in previous years.


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on November 5, 2012 - 7:43 PM
, updated November 5, 2012 at 7:46 PM
hed goes here and here
NIAGARA FALLS, Ont. – A city resident is being held following his second arrest on armed robbery charges.
Jeremy Rysdale, 27, was tracked down by Niagara Regional Police shortly after a knifepoint robbery at the Canadian Tire gas station on Bridge Street about 9:10 p.m. Sunday. He also is accused of using a gun to rob a night auditor at the Imperial Suites on Victoria Avenue about 5:20 a.m.
Rysdale was charged with two counts of robbery, two counts of breach of probation and one count of breaching a condition of his recognizance on an earlier case.
Anyone with information about either of the two Sunday crimes is asked to contact Detective Constable Ron Reece at (905) 688-4111, Ext. 2121.


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Dallas rings in the new year at Big D NYE
Photo: Nathan Hunsinger/Staff Photographer
Crowd surfing at Big D New Years Eve celebration at American Airlines Center in Dallas December 31, 2012.
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Is extreme weather the new normal?
February 2, 2013
What is up with the weather? That might sound like a frivolous question, but let's look at recent events in our area: ? The June 29 derecho caused tremendous damages in our region, knocking out powe......
To all those uneducated "just believe what they say" types.......there really IS a sucker born every minute. YOU are the suckers.
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And stupid people wonder why they're always the ones getting taken by scammers. LOL. Well if you're going to be so gullible.......expect to lose what you have.
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yep, i knew it,,those*****democrats again.
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The lying spouters of Global warming like Gore were paid Billions of dollars to try and get their propaganda out to the public/world to believe their fairy tale so they can tax the world and enrich themselves with trillions of dollars. Heck, these lying jokers in their own emails that (Oops!) accidenttally got released to the public...ADMITTED it was a fraud and LAUGHED at how stupid some folks were that believed what they were telling them. You would think a smart person would have been ticked off and offended by that...but hey, McKean and others obviously didn't get the 'insult' and continue spouting the lies and fairy tales. Notice all the globalist propaganda spouters all stand to 'gain' large sums of money if it should become law??? Intelligent folks have brains and use them. They don't follow every stupid thing that robber barons try to thrust upon nonsuspecting, non-thinking individuals. If you can 'think' no one can use and abuse and steal from you; otherwise, enjoy your trip.
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Wow; the left nuts keep spouting the lies don't they? Global warming is a LIE to attempt to TAX the entire world to make the elitists like Al Gore more wealthy. I guess McKean would like us to "ignore" his so called reference to 'expert scientists' who were CAUGHT lying and laughing at the stupidity of folks like himself/herself that are stupid enough to believe what they are spouting. That 'should' offend McKean as they were laughing at folks like her/him. They kick out the REAL scientists who PROVED the deceit of global warming. Get yourself a thermometer McKean. Then you can see for yourself temps are getting COLDER not warmer. Icebergs are still icebergs. Don't be 'gored.' Wise up; smarten up. Use your own brain. It got colder so they changed name to "climate change." LOL. Still getting colder. Fools following fools. People have waken up to the LIES of the radical left. Don't be fooled by Gore's need for greed. Don't be 'gored!'
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I can remember cold Augusts, warm January's, winters with ice storms one right after the other, Hurricanes coming up the Chesapeake Bay, the Chesapeake Bay frozen solid, every kind of weather you can imagine warm winters, frigid winters.
I think people who think the weather is strange haven't lived long enough. We've been lucky the past few years with mild winters, but you can bet your life it wont stay that way. It never does.
3 Agrees | 1 Disagrees | Report Abuse »
Nobody should have to ask the questions "Is extreme weather the new normal?" and "Is this a manifestation of the dreaded global warming issue that American politicians have argued about so violently during the last decade?" The answer is that everyone should be listening to the scientists who are the experts on global warming and who are 98% in agreement about the cause and the solution. One political party listens, and the other, the party of no, ignores science and listens to big corporations who only make decisions based on their bottom line. The rest of the world is working on a solution, and the US is spending billions to recover from one major storm after another. The same issue of your paper has a related letter to the editor talking about your stance on coal and another on "warming imperils wolverines". The ignorance of the minority is going to hurt us all, and WV was one of ten states with the most extreme 2012 weather. We were lied to a
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AndroidAWSCodeIgniterHTML-5iOSMySQLPHPWordPressSocial NetworkingAndroid PhoneiPhone
It's a complete social networking application. Features like timeline,popular & new posts and exciting messenger,connect with strangers,all these together make this app a complete social networking.
It has blend of features that you can easily relate to Instagram and Whatsapp – and many more unique features for a Chat Application.
User can upload text, photo or video by tagging other users using hashtags and share with friends on timeline and post comments & like on others posts,User will be able to see popular and new posts from all over the world.
Users can chat with each other with all new exciting animated and non animated smileys with media sharing.
User can discover unknown users and interact with them via "Meet2" feature based on wifi and location.
A customizable color based UI which helps people to stay connected with app in different mood and appearance. User can make anyone's post special with beautiful gifts.
Special Features
- Social Sign in with SMS Verification
- Inviting contacts and Friend Discovery
- Share Photos Videos Audio as posts
- Comments Like share Stickers as Gifts
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- Meet2 to discover strangers and initiate chat
- Animated Smileys
- Privacy Control
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- Content Filter (Spamming Flag content)
- In App Purchase


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Hey Babs, Can Tatar stay on the top lines now?
He played only 10:46 last night, good for #11 amongst forwards. Meanwhile, Cleary ended up #3 amongst forwards in ice time despite having only one hit, zero shots, and zero blocks. Granted, the Stars were on the power play for much of the game, but yikes.
Still, it was 5-1, so whatever.


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Face feature tracking using Gabor wavelets
Tsoumanis, Andreas
Permanent address of the item is: http://URN.fi/URN:NBN:fi:tty-200907105814
There are no files associated with this item.
Publication type: Diplomityö
Issue date: 2002-12-11
University: Tampereen teknillinen korkeakoulu
Faculty: Tietotekniikan osasto
Department: Signaalinkäsittelyn laitos
This thesis is concerned with the analysis of visual images, a field in which computational methods for extracting high-level representations of visual objects are developed. The human visual system is currently orders of magnitude better than any automatic systems that have been developed. Humans are especially adept at the recognition of natural objects, particularly human faces. The recognition of human faces is also important for many applications of image analysis, such as user interfaces, surveillance and face verification systems. The purpose of this thesis is to develop methods for tracking face features using various methods. Specially, Gabor wavelets are used as the low-level visual representation, which is somewhat analogous to what is known of the early stages of human visual processing. Subsequently, different search and matching algorithms are applied to detecting the most salient face features, i.e. the eyes, nose and lips. The work presented here has been carried out as part of the European Union Research Training Network MUHCI (Multimodal Human-Computer Interaction). In addition to the Gabor wavelet representation, dynamic programming, clustering and face geometry constraints are applied. Dynamic programming id used for tracking features over several frames of a video sequence. The computational demands for face feature detection are very high, and for this reason several techniques are used to speed up the calculations, among them clustering, frequency domain filtering and using subsampled image representations. In addition to the knowledge of the local properties of the face features, a global constraint on the geometry is also used. An audiovisual database comprising several people recorded over several weeks was specified, collected and annotated as part of this thesis. In addition, an audiovisual database from the Helsinki University of Technology was used. In total, these databases consist of approximately 6000 face images, and they are used both as training and testing material for the parameters of the face feature detectors. The results of this thesis indicate the difficulty of the face feature recognition task even with relatively constant illumination and frontal face images. Detectors based on simple low-level matching can find the eyes, which are maybe the most prominent features of the face, in approximately 70% of the cases. The lips and nose are correctly detected only in approximately 30%. With postprocessing based on dynamic programming, these percentages increase to 90% and 60%, respectively. However, these results still need to be improved to make face detection useful in most applications. /Kir10
Comment: TTY:n kirjastossa laadittu tiivistelmä


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Developers of DTC Genetic Testing Are...
NSCLC is "Major Battlefield" as Merck,...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
The ability to edit the human genome in a targeted and specific way allows correcting genes with harmful mutations, producing therapeutic proteins, and custom designing cell lines to model human diseases, such as cancer. Many feel that gene editing promises to write the next chapter in biomedicine.
Science described new gene editing technologies as "genomic cruise missiles" and named them as runners up to the scientific discovery of the year for 2012 (which went to the Higgs Boson).
Added to technologies in place for the last decade, a number of other powerful new techniques are putting DNA modification into the hands of even nonexperts. Which will win out as the premier tool is something no one yet knows. Each has its advantages and disadvantages. What is clear is that readily modifying human and other genomes within a wide range of cells is now a reality.
Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate highly specific targeted genomic editing by creating double-stranded breaks in DNA at user specific locations. "You can use ZFN technology to create your choice of stable, genetically engineered cell lines or organisms harboring gene deletions, additions, or other modifications with exquisite specificity," says Greg Davis, Ph.D., principal R&D scientist for ZFN technology at Sigma-Aldrich.
The company is focusing a segment of their business on providing ZFN products and ZFN custom services. They became the exclusive licensee and distributor of such research reagents under an agreement established in 2007 with Sangamo Biosciences.
According to Dr. Davis, slicing both strands is important for site-specific mutagenesis applications because the break stimulates the cell's natural DNA-repair processes, i.e., homologous recombination and nonhomologous end joining (NHEJ). Harnessing nature's toolbox for repair allows generation of precisely targeted in vitro or in vivo genomic editing with targeted gene deletions (knockouts), integrations, or other modifications.
"Via the NHEJ pathway, ZFNs have enabled creation of knockout cells and animals at high frequency without the need for drug selection or exogenous DNA templates. This has greatly reduced timelines for isolating modified cells and animals," he explains.
Using the technology, the company has created knockout and SNP insertion cell lines in their oncology and breast cancer panels. Additionally, the Pathway and Cytoskeletal Marker cell lines comprise a suite of genes tagged at the endogenous locus that allow an investigator to monitor protein expression and localization.
A large part of Sigma's ZFN technology is devoted to custom service for its clients. Kevin Kayser, Ph.D., director of the CHOZN® platform for SAFC, notes, "Not everyone wants to be a gene-editing expert. Sometimes it is more efficient to outsource that. We provide off-the-shelf specific ZFNs to target genes for human, mouse, and rat studies in the form of cell lines and animals."
SAFC has taken the ZFN technology a step further by utilizing it to create CHO cell lines for use in biopharmaceutical applications. "These CHOZN cell lines were purpose built to enable biopharmaceutical producers to advance their molecules in the clinic faster, while adhering to their stringent regulatory expectations," says Dr. Kayser.
SAFC currently provides both glutamine synthetase and dihydrofolate reductase knockout CHO cell lines to biopharmaceutical customers, as they represent the two most commonly used metabolic selection systems in the industry, according to Dr. Kayser.
Translating technology to patient treatment is the ultimate goal of many gene editing pursuits. Sangamo BioSciences is providing encouraging early data on the utility of ZFN therapeutics. They are now in a Phase II and two Phase I/II clinical trials to evaluate SB-728-T, a ZFN-modified T-cell product for the treatment of HIV/AIDS.
Philip D. Gregory, D.Phil., vp of research, and CSO, describes the company's approach. "HIV-1 gains access to target cells by sequentially binding the viral pg120 Env protein to the CD4 receptor and a chemokine co-receptor. The major co-receptor is CCR5 that is expressed on key T-cell subsets. It is relatively common for Western Europeans to have a 32-base pair deletion that confers resistance to HIV-1 infection and AIDS in homozygotes.
"We are utilizing our ZFN-mediated gene disruption technology to disrupt the CCR5 gene in cells of patients' immune systems. This effectively creates an immune system within an immune system. The patient now has a population of cells that are permanently resistant to HIV and opportunistic infections and thereby mimics the immune system of those that carry the natural mutation."
Sangamo is also employing its ZFN platform to examine curative treatment for a range of monogenic diseases such as hemophilia and lysosomal storage disorders like Gaucher and Fabry diseases.
"ZFN technology is perfect for the goal of personalized medicine, especially for development of potentially curative approaches to single-mutation diseases. An example is our program that targets hemophilia in which the liver fails to produce sufficient amounts of coagulation factor IX due to a single mutation," says Dr. Gregory.
"We designed a ZFN approach in mice that could induce gene targeting in the liver to allow delivery and correction of the mutated gene. This strategy succeeded in the stable liver-specific production of human Factor IX protein to 100% of normal circulating levels."
The study was performed in collaboration with the laboratory of Katherine A. High, M.D., director of the Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia.
According to Dr. Gregory, "All technologies share the common goal of targeting the genome for therapeutics. This represents a huge paradigm shift for how medicine is performed. ZFN technologies are leading the field."
One of the new kids on the block is a tool that promises easy access to gene editing by even nonexperts in the field. TALENs (transcription activator-like effector nucleases) work much like ZFNs to home in on and cut specific genomic DNA sequences. But unlike ZFNs that bind to groups of three base pairs, TALENs binds to individual nucleotides, allowing their use anywhere on the genome.
Cellectis believes its TALEN™ technology will greatly speed up the process. "We jumped into this technology initially because we could see that it provides a very efficient and rapid means to perform gene editing," indicates Philippe Duchateau, Ph.D., CSO.
"In only about one week, one can design and begin implementing gene-specific modifications. Additionally, our TALEN technology has a number of advantages over other technologies. They are less costly to produce, are really efficient tools, and may be designed to target virtually any DNA sequence. Genome editing is no longer a matter for the specialists."
Dr. Duchateau also notes recent improvements enhancing efficiency of the technology.
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Ball State Sports Link: The Jake Brehmer Story
Diving is a sport that's a lot like life itself. It has its ups, its downs, you fall and you get back up.
Being able to manage so many unpredictable twists and turns takes intense physical and mental concentration. Unless your Ball State diver Jake Brehmer.
Here's the SL exclusive produced by Chris Renkel Jr, Christopher Kosinski and Emily Barker.
Join The SL Nation: Connect with over 7,000 other fans and get daily updates and videos with BSU's largest social media network for BSU Sports -- Ball State Sports Link.
Like SL on Facebook: www.facebook.com/ BallStateSportsLink and Follow SL on Twitter: @bsusportslink.


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The Derwent Coloured Pencil Collection Tin 24 is the ideal set for sketching in colour and with the coloured sticks you can easily add texture, giving your coloured sketches extra definition.
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Interfaith Leaders
Interfaith Leaders (IFL) is a student-led initiative of the Jay Phillips Center for Interfaith Learning.
We are students from a variety of backgrounds coming together to promote dialogue, friendship, and service among people of different philosophies and ways of life on our campuses.
Better Together Campaign
The Better Together Campaign is a national student campaign on college campuses for interfaith action. CSB/SJU has been participating in this campaign since August 2012. The Better Together Campaign was developed by the Interfaith Youth Core (IFYC). For more information: www.ifyc.org.
Through the Better Together Campaign, students VOICE their values, ENGAGE others, and ACT on community issues. This year's action issue at CSB/SJU is equal access to quality education in the St. Cloud area.
Better Together Campaign events include film screenings and discussions, lectures by guest speakers, panel programs, and shared meals.


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Why hasn't US gone after hackers?
June 4, 2013
Think for a moment about what would happen if a foreign power launched a military attack calculated to destroy billions of dollars' worth of U.S. property — but without causing any injuries or deaths....
Lets run right over to China and arrest those SOB'S
Why don't we find away to protect our system's ?
It's not like it's something new .
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Giant Killers
|Noah Lowry, LHP
153/67 K/BB, 18 HR in 174.2IP
|Carlos Zambrano, RHP
174/75 K/BB, 14 HR in 188.0 IP
|CF Jerry Hairston Jr
|CF #Randy Winn
|SS Ronny Cedeno
I always seem to remember
I always seem to remember Dusty leaving Z in and then him giving up 3 ER in the last inning a few times this year. So his ERA is a bit misleading, although I have no statistical backing and too tired to dig it up.
Just to fuel the
Just to fuel the Dusty-doesn't-play-youngn's argument.
Hardball times mentioned how several wild card contenders were being led by young players here:
Which is interesting since Dusty told me you can't win at the same time you play young kids.
I got curious and checked out some numbers:
Player A .234/.275/.404 (47 AB)
Player B .250/.300/.554 (56 AB)
Player A is Ryan Howard. Player B is Jason Dubois. Now of course there are other factors here. Dubois can't field, Howard plays first base, injuries played a part, and Howard is long term a much better prospect - but the point is that for the beginning of their career Howard was outhit by Dubois, and for Dubois' efforts he rode the pine, while the Phillies stuck with their rookie who is now hitting:
I realize Crunch will be around to remind me all Cubs rookies suck and what-not, but I just thought I'd show that as an illustration of what can happen if you show faith in players with a stellar minor league track record, which both players have.
Hooray! We get the
We get the Cedeno/Murton lineup against lefty Noah Lowry.
I can't remember the last time we saw the same lineup two days in a row.
No Walker again...Neifi at 2B. I'm sure this 2 games off isn't making Todd Walker happy since he hits lefty's well enough to be playing against them. Is he hurt?
Is he hurt? Just his ego....
Is he hurt?
Just his ego....
"I realize Crunch will be
"I realize Crunch will be around to remind me all Cubs rookies suck and what-not"
if you'd bother to actually read what i write you'd know what i have to say about rookies, not what you think. you wanna put some words in my mouth how about putting the right ones in there insted of throwing a stupid fit?
and if you dont know the difference between ryan howard and jason dubois you better stick to that number hunting insted of watching kids play.
ya know, i hear a lotta shit talked to me about stuff i say, but rarely do i hear "gee, maybe i was wrong to jump down your throat" when the things i say come to bare light.
how about some accountability in this issue?
you wanna go dig up anything about me saying cedeno sucks? or murton sucks? ...yeah, i did say dubois has no biz near the bigs cuz well, he dont.
i honestly invite you to back up your accusations there dude. go ahead and embarrass me by proving me wrong.
if you'd look at what ive said about murton/cedeno/wuertz you'd see ive said a lot of good about them. just cuz i dont want to project them as superstars you must have a problem with that.
guess what...every kid this club touches isnt gonna be a superstar.
how many times do we face
how many times do we face two lefty's in a row? not many. otherwise our kids are sittin. the real good news about the lefty is no cpat...i'm pretty sure the rev johnnie b wants this .500 thing pretty bad, not to mention how bad he wants to beat frisco. lets see, wuertz, novoa, dempster all pitched last night and dusty really wants this game. i'm guessing zambrano throws a complete game, maybe 130 pitches. will we be talking about this next year if z has arm problems? how dusty wanted the .500 mark and wanted to show his old team so bad that he mortgaged the future?
Is it true that teams have
Is it true that teams have one stolen base and 9 caught stealings against zambrano all year? pretty amazing. maybe maddux ought to sit and listen to zambrano.
i'm posting my ass off
i'm posting my ass off tonight...rumor central says that kyle lohse and eric hinske are on the trading block. maybe the cubs can get both of them so mcphail can remind everyone how much the system has produced these past 11 years!
Thank goodness McFail is no
Thank goodness McFail is no longer GM.
He would have brought back Hinske/Lohse as sure as you can say Gary Gaetti/Rick Aguilerra. Any former Twin got extra consideration, we would have traded Cedeno for Christian Guzman at the trading deadline too.
I'll take back what I said
I'll take back what I said about "All rookies suck" - I had recalled a quote from somebody posting here saying, "Has it occured to anyone that all our rookies suck." I thought it was you - but I can't find it.
That said... I thought I was pretty explicit in stating I didn't think Dubois was = Howard. I certainly don't think he'll be a superstar. I was pointing out an example of a rookie on the Cubs who may have helped the team, only to have his chances eaten by Baker, and pointing out that Howard likely would have been given the same 'opportunity'. Now clearly it's not an exact comparison because Howard is blocked by Jim Thome's corpse whereas Derrek Lee would be blocking him legitimately here.
For what it's worth Ryan Howard is only 8 months younger than Dubois - I thought the difference was worse since Dubois is consistently old for his leagues - and has more comparible numbers to him than I expected (I thought Howard would blow him away).
For all of Dubois's strikeout problems, and they were bad, Howard has a BB/K ratio of .2 in the majors to Dubois's .1. In the minors Dubois has a career line of .299/.379/.550. The batting average frankly shocks me, and a BB/K ratio of .5. Howard has .290/.373/.528 and a BB/K ratio of .4, and only slightly younger with three years in A ball, Dubois started late and spent 2. Sorry for number hunting crunch - but I'm not a major league scout and have no other recourse in evaluating minor league talent. And I still don't think Dubois will ever be as good as Ryan Howard.
it wasnt me..i'll take it as
it wasnt me..i'll take it as a friendly jab..no worries.
and about howard vs. dubois..there's major differences between how the 2 handle a bat and handle offspeed stuff.
i honestly believe dubois will be fighting for a job 3-4 years from now with a team while howard will enjoy a nice career that will pay him handsomely.
for a big guy, howard actually isnt a statue..he reminds me of matt stairs with a smoother swing.
well...maybe matt stairs is
well...maybe matt stairs is a bad compairison given the height/etc. and howard should have more power...but theyre both big guys who arent good for just covering 3' of area...
Frankly it's been a looong
Frankly it's been a looong day at work and a frustrating cub season, so I was cranky. I realize I was inviting a board pissing match - and that's just silly. I know better.
And of course Dubois/Howard play different positions. I had intended to put in a few other young guys too as examples, I just see Dusty as managing by Sports Radio sometimes. Put him in, take him out...Too reactionary especially in a sport as built on failure in baseball, and way too old school manager.
its all good...you thought i
its all good...you thought i said something i didnt and if i did, your statement would have been valid.
it takes these kinda back/forth to clear it up sometimes...at least it was quick.
don't get me wrong, I'm
don't get me wrong, I'm really glad that Cedeno/Murton are in the lineup...but it seems to me that once again this lineup is cockeyed. Shouldn't Murton be hitting 2nd?
I don't mind Cedeno in the 2 spot (certainly preferable to Neifi) but I'd like to see the higher OBP player up there. I don't think that it's an issue of speed at the top of the order since Murton beats out his share of infield hits too. It might have added a run if he was on base for the DLee triple.
Why even bothering trying to
Why even bothering trying to logically analyze the illogical?
Whiny Cubster-- Who cares
Whiny Cubster-- Who cares at this point? At least he's in the line-up!!!! Oh, and wait, he has ANOTHER HIT and a WALK. Wow, we could've never used him this year at all. I'm glad Dusty saved him from failing (sarcasm) I say let him be the starting LF next year and spend big cash on Giles or Dunn, a starting pitcher and Johnny Caveman.
Why even bothering trying to
Why even bothering trying to logically analyze the illogical?
That's the problem...Dusty needs pointy ears.
anyone heard ANY aram news?
anyone heard ANY aram news?
...and here comes Korey to
...and here comes Korey to save the day
Even when he gets on base
Even when he gets on base Korey gets out.
Just not his year. Hopefully he can rebound. He seems like a nice guy
Murton has an OBP of .750
Murton has an OBP of .750 for the game and Baker puts in Cpat for D again and not only that he pinch runs Murton because what he couldn't run like Ichiro. Let him play a complete game. Man I can't stand this shit! And they want to give him an extension!
murton wasnt gonna see
murton wasnt gonna see another AB and corey was in for his D...at least keep it in perspective...wanna talk about murton giving away a run to a pitcher on 3rd by not hitting cedeno's cannon arm as a cutoff man and just tossing it to 2nd?
enjoy a game once in a while..its fun stuff.
crunch....they can't have to
crunch....they can't have to find something about Baker to complain about. Its TCR.
i dont even care about
i dont even care about people complaining about baker...except those that just wanna bitch about everything without realizing most manager in mlb does it.
baker has quirks that drive me nuts, like insisting on the speed up top at the expense of anything. im all for speed up top, but you dont need the 1 and 2 guys both doing it if theyre both low ob% hitters.
he's got an obsession with contact hitting #2 slot guys that i understand but dont like.
but geez...picking apart every move a manager makes you can paint any manager an idiot...go to fire(anymanager).com to see this in action.
Two comments: I was also
Two comments:
I was also curious on Aramis news.....haven't heard any lately. Just wondering if anyone else had.
I think it is funny how Dusty seems to always play Cedeno & Murton together, no matter what. I guess he can say he likes them vs. lefties (which I can see for Murton, but not for Cedeno, esp. if the platoon winds up being w/ Walker, as Neifi seems to start at 2B often w/ Cedeno at SS). It almost seems like Dusty thinks "We'll play the rookies today, so we get it out of the way" or "Time to play the vets. today". I didn't look up all the boxscores, but I am fairly certain that more often than not, its either both or neither of Cedeno/Murton.
I think it is pretty important the Cubs see as much as they can from the two rookies this month, and some pen guys also (JVB), so they can evaluate next year. OF & middle IF are our main spots that the $ will flow into, so while Sept. #s may be misleading, seeing the kids play is better than not. Also, I beleive they probably give us the best chance to win on most nights anyways for the remainder of this year, so its a win-win.
Keep winning Cubbies!! There's still hope!!!! (Hey, it may be .1% or something, but a guy can dream, can't he?)
That was a bit more than
That was a bit more than two.....oh well.
It's actually kinda fun not
It's actually kinda fun not worrying one bit about the Cubs and coming home and checking the score at the end of the game and saying "they won, that's nice"
I wish I gave a shit about football season. Bring on April 2006
Let's see combine the 6-1 roadtrip we had in May with the 6-1 roadtrip we are having now...ignore everything else, and we have a good season
"I wish I gave a shit about
"I wish I gave a shit about football season. Bring on April 2006"
hahah..rock..me, too.
Crunch, The latest I heard
The latest I heard on Ram was he wants to come back as soon as he can probably to get 100 RBI. He has 92 so to get to 8 he would probably have to come back by like next Wedsnday or so. If he aint ready in 2 weeks my guess is that they will shut him down. On the Murton and Pat thing I can enjoy the game and critize a typical Dusty trying to over manage move. In the long run it probably isnt that big of a deal but it is just annyoing to me and I am sure others on this board. I just looked at the WC standings and NYM and WAS are starting to come towards us. If we can sweep this SF series we could be in 4th at least 6.5 games behind Hou who we play 7 times. Maybe were not dead.
Crunch--"and about howard
Crunch--"and about howard vs. dubois..there's major differences between how the 2 handle a bat and handle offspeed stuff."
Indeed. Howard can't hit left-handed off-speed stuff to save his life. Dubois just can't hit any off-speed stuff. Big difference!
Howard, for the record, is hitting .130/.161/.130 in 56 plate appearances for his Major League career against lefties. That's 7-for-54, all of those hits singles, with 2 walks and 27 strikeouts. Yes, I repeat, 27 strikeouts in 56 plate appearances.
So uh platoon Dubois and
So uh platoon Dubois and Howard. That's it.
ryan howard will K a ton
ryan howard will K a ton always...he'll also probally hit 40+ HRs regularly and **DESTROY** any fastball left anywhere near the zone.
he's been getting increasingly good at waiting for his pitch insted of trying to hit any pitch...something dubois never got the hang of and it looks like never will unless someone in cleveland can whip im into shape.
howard isnt a wild swinger...dubois is.
howard is a guy who's swing has been successfully retooled to hit inside pitching and defensively though he's not gonna dive all over the place for the ball, if you get it to him, he'll probally glove it.
his major problem (besides jim thome being under contract and him being too slow to play anywhere else) is those lefties.
howard is a guy who can compensate to hit big league pitching whereas i dont see dubois doing much with his hack swing.
Ienpw--"So uh platoon Dubois
Ienpw--"So uh platoon Dubois and Howard. That's it."
There's probably no point. Dubois doesn't even hit lefties that well.
Dubois knows all there is to know about destroying fastballs, Crunch. Of course, the problem is that he thinks just about every pitch is a fastball that he can destroy, swinging accordingly. Or at least that's been the case in the majors.
Sorry, can't resist- what's
Sorry, can't resist- what's the big deal about Dusty's superior managerial skills if & when Barry returns during this series? Does ANYONE realistically think that Barry would rate IBB after sitting so long? Oh- I know: like the famous scene from Karate Kid when Evil Coach tells the blond headed kid: "Sweep the Leg!", maybe Dusty will call for beanball on the post-surgical knee?
"Dubois knows all there is
"Dubois knows all there is to know about destroying fastballs, Crunch. Of course, the problem is that he thinks just about every pitch is a fastball that he can destroy"
hahah...they both put on one hell of a batting practice show, that's for sure.
I am also much more inclined
I am also much more inclined to reflect positively on the season if the club continues to finish strong. Didn't Dusty call this the "salary drive"?
Because I'm a cheapskate upper-deck guy here at PNC [skyline view is better up there too] my wife bought me box seats as a birthday gift, for Cubs vs Pirates last week here in the 'Burgh. She bought them months ago and couldn't have guessed who would be pitching, but it was Maddux! "Thanks Honey! How'd you do that?"
I got to reflect during the game that over our 21 years of marriage, I taught her to watch and enjoy the game, especially this savvy new guy pitching for the Cubs, when we were still practically newlyweds. And she shared our mutual heartbreak, but our sad recognition of the inevitable, when the budding superstar backed his bags for the 'Big Time' and went to Atlanta. And she even begrudgingly began with me to root a little bit for the Braves on occasion, especially during those golden days of that incredible starting rotation...man, oh man. Can you still name them?
Since we were sitting close, I gave her the binoculars and told her to have a look. "What should I look at?" she asked. "At the Hall-of-Famer, of course; you'll be seeing him again on a podium in a couple of years." After the game, she reflected, "He does a pretty good job of keeping the other team from scoring runs, doesn't he?" [True, this was the Pie-rats; but this could never have been more true than in his next (12th) win in StL, getting out of a bases-loaded-no-outs jam in the third. Edmonds GIDP.] Gutty, gritty, moxie, nervy, savvy, more? Character that would stand the test of any time in baseball.
So hoist at least one for Maddux down the stretch, especially if his 15-win mark remains in sight - don't believe for a moment that he's not looking for a reason to compete [Doesn't he golf?] And remember that there are some things which transcend losing seasons. Baseball is a team sport, but comprised of collective individual performances. And there's some things about a pitcher's individual performance which transcend their W-L record. But it's up to you to tell your kids about those things when you're looking at Maddux's plaque in Cooperstown.
Dave, I think Maddux's
I think Maddux's competiveness could lead him to retire. If he thinks that he will be just serving up BP to hitters he would retire he is too proud to get beat around like a guy brought up from AA. I dont think it is going to happen.
Apparently Damon considers
Apparently Damon considers Anaheim a close second now behind Boston. Probably ain't gonna happen for the Cubs.
I know several people, including a few of the writers, have been overly critical of Hairston's defense in center, but is he really that bad? Compared to Korey, he's certainly not as good, but he made some great catches last night, and from my limited look at him, he's sure-handed and his range seems to be decent if not great. Of course, then there's his arm. Oh well, just wondering.
In what world is Maddux just
In what world is Maddux just serving up batting practice? Yes, he's not the old Maddux by a long shot. But if recent trends continue he's going to basically have the exact same year he had last year and the year before, minus perhaps one or two wins. Everything else -- innings, WHIP, BAA, ERA -- is going to be very, very similar.
Now if you'd said he wasn't worth $9 million, well, okay. He isn't. But he is still better than what a good number of teams throw out there every fifth day.
Forget about Damon. All he
Forget about Damon. All he wants is $$$$! When he is in Chicago its all about how he wants to be with the Cubs and when there playing ANA its all about how he wants to go there. I am sure because he is in NY its all about how respects the Yankee tradition and how he would not mind playing with Beltran again and would play LF if they want to put Floyd at 1b. Hairston is fine and if it becomes a problem we can call up Pie.
I did not say he was serving up BP. What I said if he thinks he won't have the stuff to compete at a suffient level I could see him retiring.
Have you even watched
Have you even watched Hairston play defense in Center? It makes me puke. Anything that's hit behind him is a hit because his routes are pathetic.
I am far from being sold on Felix Pie. He's too much of a Version 2.0 Corey Patterson for my tastes.
The only way Greg won't come
The only way Greg won't come back is if he feels unwanted. It's cheap-ass horseshit on the Cubs part, giving him signals that they possibly don't want him back next year. Greg can still pitch, plain & simple. He's probably the smartest player in the game and he'll adjust to continue winning.
He's had 5-6 games this year that should've/could've been wins if the Cubs had an offense or a bullpen. If he pitched for the Cardinals, he'd have 16 wins right now. There's only 1 guy on that staff that has that many wins.
IENPW, When you compare
When you compare Hairston to the other alterntives he might be the best option.
FA CF's other than Damon
Cruz Jr.
Burnitz (assuming he gets bought out)
Biggio (if really want to see him play CF)
B. Williams (he has no legs)
D. Roberts
Guys who will get traded
Bradley (if he goes on Prozac I'll take him)
Guys who will most likely get non-tendered
Sarge Jr.
Guys who might be traded but probably wont
W. Pena (can play there but no good)
Obiousily I take Hunter and Rowand from Group 4. But Rowand is a 5% chance of getting traded, and even if he does it wont be to us. Hunter is owed 2/22. Of the other 3 groups the only upgrade from JHJ I see is Lofton (maybe),Kapler (I doubt he leaves BOS though) Payton (he is a GT guy and we know Hendry loves those guys), Roberts, and Winn. I doubt Burny would come back if his option is turned down.
IENPW: "Have you even
"Have you even watched Hairston play defense in Center? "
Yes, and this is what I am talking about. Did you see him play last night? He made catches on at least two balls that were hit over his head. So I don't get your point.
I'm looking for reasoned analysis of how his CF defense sucks and not just visceral reactionary statements.
I didn't see last night's
I didn't see last night's plays, but did he actually get a good break and make a great play on a ball that most players wouldn't reach OR did he misread the ball and have to do something spectacular just to make up for his initial error?
Before last night's game, I've seen him play more than I needed to in centerfield as he reads the ball quite poorly off the bat. As John Hill mentioned, he generally takes a step-in and then has to recover, his route to the balls are just plain horrible and he almost always turns himself the wrong way. Now he has good enough speed to make up for some of those faults and makes the routine look amazing all too often. But right now he's a defensive liability out there...
That being said, we got nothing to lose by letting him play. He's obviously an option out there and it will take time for him to get proper jumps and proper reads off the bat and we're certainly at the position to afford him the playing time right now. There's a good chance he may never learn it, but playing (along with practicing) are the only ways he'll go about getting better.
He should be sent to winter ball if this is an option for next season, not sure if he'd take the assignment though...
Rob, I hear your points,
I hear your points, most of which, as you mentioned, JH has said before. I guess I personally have just not noticed those initial miscues as much.
As for last night's plays, no, they were pretty great. The first clearly would have been a double in the gap by Durham (I think) and Hairston made a great effort to just get to the ball and a solid jumping catch back and to the left. The second was a hard hit, very very low liner by Snow (I think) that clearly would have brought at least one run in. Hairston had to charge forward and then leaped straight forward to catch the ball right before it hit the ground. Even more impressive than the first catch as it was harder to read and play. He almost made the exact same catch an inning later but seemed to lose the ball in the stadium lights as it glanced off his glove. Nevertheless, I was impressed.
When you compare Hairston to
When you compare Hairston to the other alterntives he might be the best option.
Corey Patterson for one, could be a better option. Of course if he hits like he did this season, he won't. His entire career Korey has gone into long prolonged slumps, but he's also had long prolonged hot streaks. He hasn't had them this year. What Corey Patterson did in 2004 is better than Jerry Hairston. Call me an idiot for still staying with Corey, but I am not asking for him to be a superstar. I am thinking there's a very good chance he returns to the player he was last season. Even last season was less than expecting for him.
I'm looking for reasoned analysis of how his CF defense sucks and not just visceral reactionary statements.
Sabermetric fielding stats are very primitive at this time, but they do show that Hairston is below average despite limited action in CF this season. Yes, I saw what he did last night. He made two good catches coming in almost making a third. His first step is in, it's no surprise he's good at balls when he has to charge. I don't think I need to talk about my comment that he takes awful routes on balls behind him. Anyone who has watched him play CF this season can see that. He gets turned around on most of them.
He almost made the exact
He almost made the exact same catch an inning later but seemed to lose the ball in the stadium lights as it glanced off his glove. Nevertheless, I was impressed.
Or it could be because he took a circular route on the one he missed (which he did).
Recent comments
j.buchanan with a nice start...5ip 2h 1bb 3k, 0r/er
zobrist with 2HR and a double through 8
heyward 0-4 :(
Mark Gonzales @MDGonzales
Soler likely to return Sunday, Maddon says
Right now, I'd like to see the Mets first, Giants 2nd.
I believe that since most of the team from last years' NLCS is on the squad this year, they will really amp their game up even more to kick their ass in payback for 2015.
The Giants just do not have the depth in years past, and I think all things equal - and at Wrigley - they could handle them.
I do not want to see the Cards, period. Or their fans, media, or Joe Buck.
I don't want to play Braves in the first round. Any friggin team in the league can win 3 of 5..I hate the first round. Furthermore, I wanted to play the Marlins in 2003 and the Mets over Dodgers last year.
With that said in reverse order:
3. Cardinals: It will be devastating to lose in the first round, but even worse to their main rival. It is increased incentive for the Cardinals, especially after last year. Cards would have nothing to lose, Cubs have everything to lose.
2. Giants: Rotation in the playoffs scare me a bit, but what a lousy team.
1. Mets--because of the losses in the rotation
2. Giants--because they're not the team they were BUT they maybe have bullshit even-year magic?
3. Cardinals--because rivalry and not making the playoffs hurts them more than losing in the NLDS plus getting eliminated by them in the playoffs would make for horrible sports commentary next throughout next season.
Who's asking?
CLE/DET rained out last night already, possible rain-outs in New York (vs. Baltimore), Boston(vs. Toronto) and Philly(vs. Mets) this weekend too.
Not only games involving playoff spots that would need to be played, but any that involve home field advantage.
I got the first one! Second one I'm not even sure what even/odd betting is.
any opponent preference for NLDS?
Mets are down to 1 great pitcher instead of 4. Syndegaard may pitch Sunday which means if Mets win the WC game, he'd be set up for Game 1. There's a chance they clinch a spot by Sunday so he'd pitch the WC and then we'd probably get Colon for Game 1. They've certainly had the hottest bats over the last week and month out of the WC options.
A couple of Cub related puzzles.
Can't teach height and thinness
Hopefully Pirates don't call up A. Lincoln.
j.buchanan going friday...should be...baseball...or something like it.
Wow. I didn't know they could do that.
Nice for Willson, not so much for Addy.
Game is officially called...also officially a tie.
Stats count, no make-up date of course.
Yeah -- seeing the weather -- I hope KB and Rizz are inside, wrapped in blankets and drinking hot chocolate.


text:
Top Definition
A brown trail that leads typically from the anus to the knee along the inner leg brought on my loss of bowel control. Usually this occurs in the older population (70+).
Dude, my grandpa needs to quit wearing shorts, his rust stain left a mark on the couch again.
מאת Zaterion 12 בדצמבר, 2005
Trending Now
Can you define these popular missing words?


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The act of standing in front of a bowed or seated male or female with an erect penis. Placing said penis on each shoulder and head in the same manner as king or Queen dubbing a true knight.
As with tea bagging this action is sexual in nature usually meaning to gratify, punish, embarrass, or promote laughter.
As with tea bagging this action is sexual in nature usually meaning to gratify, punish, embarrass, or promote laughter.
" Ian was asking to be Knighted after refusing to make me a sandwich"!
מאת Atom Bianchi 7 בפברואר, 2009
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to get dunked on so hard that you land on your back
DeAndre Jordan got the alley oop from CP3 and knighted that dude.
מאת pricerman 11 במרץ, 2013
Receiving a blowjob while in a castle. This can be an authentic pre-16th Century castle or a later reproduction made using the techniques of Western European castle engineers.
You: "Dude, I was on a date at Bancroft Tower and the girl blew me in the castle!"
Friend: "Oh my God, you got knighted!"
Friend: "Oh my God, you got knighted!"
מאת blankcastle 22 במרץ, 2013
Facing your partner, with them on their knees, place one's penis on one shoulder shoulder then the other, in a manner akin to a king knighting a squire.
Before getting a blow job, Bob knighted Becky and she like it!
מאת Dr. Dre-chuck 14 באוגוסט, 2009
The act of being beat, hit, or crushed with a nightstick by another person or object.
Last night on my way home, some police stopped my car and knighted me.
מאת Gekode 22 באפריל, 2013
When a guy cum on her shoulders and after that he declares her ma'am and stand up proud.
i totaly knighted my girl last night, she's now a ma'am.
מאת HairyPotterFD 4 באוקטובר, 2012


text:
Exclusive Capital One Sharebuilder Promotion Bonus Code
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(Updated 10/5) If you're looking for an exclusive Capital One Sharebuilder promotion code, you've come to the right place.
Capital One Sharebuilder is the buy-and-hold investor's dream and we have some promotion codes that will help give you a head start. We have partnered with Capital One Sharebuilder to bring you an exclusive $25 promotion code that isn't available anywhere else.
The exclusive code is: 25WO10
To use the Capital One Sharebuilder promotion code:
- Click on the Apply Today! button,
- You'll be taken to an Capital One Sharebuilder page, click on the "Get started today" button.
- On the next page, it says Account Type at the top, you'll see a white box with the words "I'm responding to a promotion," – check that box,
- The page will reload and then a new box will appear – that's where you enter in the code.
It sounds complicated but it's pretty easy, it just takes a few words to explain it.
Do not open multiple accounts. You cannot get multiple bonuses for opening multiple accounts so don't try to, readers have reported receiving this email:
"It has been noted that you recently opened multiple accounts with identical registration information.
We have restricted from activity all but the first of such identical accounts. ShareBuilder is closing these additional accounts under the provisions of Section 10 of the Account Agreement. Future identical accounts will be likewise restricted.
IMPORTANT: If you have already placed funds in your account, they will be returned to the bank of origin after the normal hold period. If you funded your account with a check, funds will be sent by check to the address of record on the account. If there were securities purchased, those trades will be cancelled."
Terms & Conditions of the offer:
You must open a new account with ShareBuilder and deposit at least $25 to be eligible for this promotion. ShareBuilder will deposit a $25 bonus approximately 4-6 weeks after your first $25 deposit. The $25 bonus offer is available for Individual, Joint and Custodial accounts only. Offer not valid for IRAs or ESAs. The $25 bonus from ShareBuilder is not available for withdrawal for 90 days after it is awarded to your account. This offer is not valid with any other offers and is non-transferrable. Limit one ShareBuilder account bonus per unique customer or custodial beneficiary. ShareBuilder reserves the right to terminate this offer at any time and to refuse or recover any promotion award if ShareBuilder determines that it was obtained under wrongful or fraudulent circumstances, that inaccurate or incomplete information was provided in opening the account, or that any terms or ShareBuilder's Account Agreement has been violated.


text:
on November 9, 2012 - 10:42 PM
, updated November 9, 2012 at 10:43 PM
Although the vote isn't until May, the Cleveland Hill School District already has begun its budget planning public sessions with a presentation before a Board of Education meeting this week.
Administrative officials made a grim forecast as they struggle with decreased state revenue.
Last year, the district rallied against what they perceive to be an inequitable state funding formula that rewards schools with large tax bases, leaving small, lower income communities like Cleveland Hill in the wake. This year's budget message is the same.
Superintendent Jon MacSwan explained that the state revenues that have helped Cleveland Hill in the past are no longer there.
If the district received just the average state aid percentage, it would help Cleveland Hill enormously, he said.
"We are still below our 2007-08 school year funding," he said Wednesday night.
Officials are taking issue with a foundation aid formula that isn't fully funded, a gap-elimination adjustment option that cuts district funding to balance the state's budget, and unfunded mandates that tie up districts with administrative costs, including the recent teacher evaluation system required by the state.
"We continue to hemorrhage our financial reserves," said Business Manager Dennis Corsaro. "This is not just Cleveland Hill. This is all over the state. It's not an upstate-downstate issue; it's a wealthy versus non-wealthy issue."
Corsaro pointed to figures that cite Cleveland Hill as one of the poorest communities in Erie County, yet it also had one of the highest funding cuts per student, which averaged $1,303 last school year, compared to the $794 average statewide. Officials say many of the decisions regarding district funding are political.
"That's the problem with the state aid formula," Corsaro said.
Cleveland Hill administrators advocate a new funding system that would consider area poverty levels and demographics, how much the local district can contribute, property values and the income of the community, and measures for cost effectiveness.


text:
Two 15-ounce cans garbanzo beans, drained and mashed
1 package McCormick's original taco seasoning
1/2 cup water
1 green pepper, diced small
1 red onion, diced small
1 package Mission flour tortillas
shredded lettuce
taco sauce
Place mashed garbanzo beans in medium skillet, sprinkle with taco seasoning packet - then stir in 1/2 cup water (less or more for desired consistency) and mix thoroughly. Simmer on low heat 15 minutes or until bean mixture is hot and thickened.
Wrap tortillas in foil and place in 325 degree Fahrenheit oven until warm.
Spoon bean mixture in center of warm tortillas, top with lettuce, green peppers, onions and taco sauce.
Great side dishes are Spanish rice, homemade guacamole or fresh avocados with tortilla chips and Mexican corn.


text: Apple has released a minor software update for Apple TV 2 on Monday. Version 4.4.1 (build 9A335A) was supposed to fix an issue that required a "small number of Apple TV units" to be connected to iTunes in order to complete the update. There were no new features in this release. Apple later pulled the 4.4.1 update after reports from the Apple TV users that the new update was causing even more issues (bricking the devices) than version 4.4. We will let you know as soon as the new software is out again.


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Officials say the death of a Dona Ana County Detention Center inmate was related to cocaine use.
New Mexico Office of the Medical Investigator said Thursday that 57-year-old Hermilo Salcedo choked to death Aug. 5 after trying to swallow a bag of cocaine.
Salcedo died three days after being arrested on drug trafficking charges. Early on the morning of Aug. 3, Salcedo underwent a full-body search during booking when an officer found a plastic bag of cocaine.
Salcedo reportedly tried to swallow the bag, choked and lost consciousness. The autopsy report said he then went into cardiac arrest. Emergency medical personnel removed the lodged plastic bag after about 20 minutes.
The report says Salcedo was resuscitated, but "there were (no) signs of brain activity."
Report: NM inmate died from choking on cocaine bag
Officials say the death of a Dona Ana County Detention Center inmate was related to cocaine use.
Copyright 2012 by KOAT.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Lawmakers to debate budget, death penalty and pot in upcoming special session
Video shows officers accidentally shooting 6-year-old
APNM offers $5,000 reward after Great Dane brutally attacked, killed
Rio Rancho schools say snakes caused power outage
PNM to appeal the rate hike approved by state regulators


text:
Road Disc Brakes Go Mainstream
Wheels, frames and components all ready for road hydraulic disc brakes.
2016 Triathlete Buyer's Guide: Best In Class
2016 Triathlete Buyer's Guide: Bikes
2016 Triathlete Buyer's Guide: Bike Computers And Power Meters
2016 Triathlete Buyer's Guide: Bike Cases
2016 Triathlete Buyer's Guide: Components
Suit Up! 9 Wetsuit Reviews
A Look At Finis' New Edge Fins
Quick Look: SwimFast Ergometer
Can A Data Watch Improve Your Swim?
2016 Triathlete Buyer's Guide: Wetsuits
Ensure Your Bike Is Race Ready After Travel
Three Awesome New Tri Helmets At Interbike
Argon 18's Game-Changing Aero Concept Isn't A Bike
Photos: Fun Tri Finds From 2016 Interbike
First Look: Diamondback's All-New Andean Triathlon Bike
Spruce Up Your Swim With Time-Trial Workouts
Quick Set Friday: Race 75s
Video: Open Water How-To Series
Quick Set Friday: Build With Recovery Kicks
Quick Set Friday: Sprint, Smooth, Strong
What's Holding You Back As A Cyclist?
When To Climb In A Seated Or Standing Position
Don't Dread The Descent!
Hour Of Power Triathlon Brick Workout
Master The Bike With Chris Lieto: Cornering Skills
Is Your Run Improving?
One-Hour Workout: Push Your Engine Then Recover
A Workout Series For Improving Run Speed And Efficiency
One-Hour Workout: Two On, Two Off Run
One-Hour Workout: 10x Quick Hills For Run Strength
Pro Linsey Corbin Shares Her Ironman Fueling Plan
Why You're Cramping On The Run
How I Fuel: Off-Road Racing
4 Common Fueling Mistakes Triathletes Make
How I Fuel: Race Morning
4 No-Hassle Post-Workout Breakfast Recipes
Recipe: Herbed Cornmeal, Cranberry, Date Muffins
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How I Did It: Getting The Kona Start
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text:
RICHFIELD - The Niemond's Independent Church has a history of outgrowing itself.
In 200 years, the congregation expanded into three new churches, all located in the mountains and valleys of the rural Richfield area.
Two centuries is the safe date that the congregation refers to as the beginning of its history, but Niemond's roots actually lay in the late 1700s with the German Reformed Church.
Article Photos
Sentinel photos by MICAIAH WISE BILGER
The Niemond's Chapel, formerly the congregation's home for decades, still is used for special services and events. The congregation outgrew the Kellerville building and constructed a new church on state Route 35 near Richfield.
According to the church history prepared for the 200th anniversary, Niemond's formed in 1811 when the German Reformed Church and the Lutheran Church of Richfield voted to construct a new church building.
The church was built on the base of a hill in Lauver Valley, now Kellerville. The deed lists the location as Mifflin County because the building was constructed before 1831, when Juniata County was formed.
The first pastors were circuit riders who served multiple denominations and churches in parts of Juniata, Perry and Snyder counties, according to the history.
By 1896, the tiny building in the valley was too small for the congregation; so, they agreed to build a new church at the top of the hill.
The new building was expanded and enhanced through the years with a new belfry in 1908, electricity in the late 1930s and stained glass windows in 1946. In the 1960s, the church expanded its vestibule to include restrooms and stairs, and dug a new basement for Sunday school rooms and a kitchen.
Services were held every other week in the afternoon, and Sunday school moved to different locations every week.
In the early 1900s, the cold winter months drove some parishioners to hold services in the Stony Run School House; and eventually, the group formed Stony Run Mission Church, according to the history.
In the 1950s, the Evangelical and Reformed churches became the United Church of Christ, and Niemond's stayed with the denomination until 1966 when its members decided to become independent.
By the turn of the millennium, the church outgrew its location again. In 2002 the congregation began to seek options for housing its expanding membership; and in 2005, it broke ground for a new building along state Route 35 near Richfield.
The Rev. Art Mott, who began serving the church in 1998, said the congregation had 45 to 50 members when he first was called to the parish. Now, membership is about 300, he said.
"It's been neat to watch all the ways the Lord has blessed us," Mott said.
As its membership grew, so did Niemond's ministries. Along with the youth ministry, ladies fellowship, Sunday school and worship team, the church now has a drama team ministry, a Gospel praise team, new Sunday school classes, a young adults ministry, men's fellowship and missions opportunities.
The members chose to preserve its history by keeping the old church near Kellerville, Mott said. They now use it for weddings, funerals and special services. It also is the home to the Patches of Love Ministry, a group of quilters who provide handmade blankets to those who are ill or face difficult circumstances.
Central to all of Niemond's ministries is the Word of God, Mott said. Services include bits of old and new worship traditions with hymns and praise songs, but the focus is on God's Word, the pastor said.
"The theme of the church has been, 'May those who come behind us find us faithful,'" Mott said.
The church has a variety of events planned for its 200th anniversary including concerts, a special Christmas production and a summer heritage day, Mott said.
More information about the anniversary events is available online at www.niemonds.org.


text:
Top Definition
When a rapper can use offensive words such as nigger and pass them off but when the likes of the general public use them it is racist.
'dude, I went up to NAS to tell him I thought his tune ''NIGGA' was the bomb and said ''what's up nigga'' damn boy, his security guards called the cops. Now isn't that hip-ocrisy bro?'
av tiest-o-holic 3 februari 2010
Trending Now
Can you define these popular missing words?
untrue to a newly adopted trend, term, or fashion
it is sheer hipocrisy to try to change wtf to "way too funny"
av j doug 7 januari 2009


text:
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
As Immunotherapy Revolutionizes the Cancer Treatment...
Immunoassays (often referred to as ligand-binding assays) are critical at many stages in the development and production of biotherapeutics. The most well-established, conventional format when performing an immunoassay is ELISA, renowned for achieving high specificity, even at very low target concentrations or with subtle differences in target molecular structure. However, ELISA requires complex and time-consuming methodologies together with specialist skills in order to achieve quality results. Assay development is also slow, typically demanding at least two to three weeks for development and optimization of each new assay.
Efforts have been made to improve immunoassay performance, such as introducing multiplex platforms to handle large sample volumes, reducing turnaround times, and, therefore, increasing productivity. Numerous kits offer to reduce assay development times in addition to improving reproducibility. Nevertheless, these steps forward are not without their own issues. For example, cross reactivity, cross talk, and matrix interference often present challenges with standard multiplex assays.
Additional pressure for faster development of robust assays stems from the outsourcing trend. Assays that can be easily transferred between labs and used throughout the biotherapeutics workflow, from research through to GxP environments, are needed. In addition to cost pressures, bioanalytical labs are increasingly faced with demands for faster turnaround times, and the need to carry out a large range of analytical investigations, often made difficult by limited sample availability.
A multiapplication alternative to ELISA available in an open format suitable for a broad spectrum of assays, requiring minimal development time and consuming less sample per assay, is becoming necessary to meet industry demands. Miniaturization and increased automation will allow laboratories to cut project timelines, while eliminating user error and fulfilling requests for increased testing.
MedImmune had been using ELISAs for process-related impurity measurement, specifically looking at the levels of host cell proteins (HCPs). The company recently identified a need to increase sample throughput and efficiency in order to handle more projects and meet the requirement for more analytical sample submissions.
Following a review of available technologies, MedImmune selected the Gyros immunoassay platform (Gyrolab™ workstation with Gyrolab Bioaffy CDs) as a prospective solution for carrying out assays at nanoliter scale in a simplified, automated format, with the potential for vastly reducing turnaround times.
A head-to-head comparison using both ELISA and Gyrolab to quantify levels of HCP across 38 in-process samples was carried out. The main goals of the comparison project were to simplify sample preparations, develop more robust assays with broad dynamic ranges and high precision, and achieve higher throughput and faster time to results. Evaluation was based on four main parameters including: sample results, turnaround time, analyst hours, and reagent consumption.
Günther Reichenberger ([email protected]) is senior product manager at Gyros.
Günther Reichenberger ([email protected]) is senior product manager at Gyros.
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text:
Top Definition
When you use your elastic waistband pants as your shirt, bra, and pants.
Sue was getting dressed for a trip to wal-mart and all she had were a pair of elastic waistband pants. No shirt or bra, just pants. So she put them on and pulled them up just enough to cover her floppy boobs, turning her pants into a pair of shirbrants. See "people of wal-mart" for picture example.
автор: no-you-didn't 14 декабря 2011
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text:
New report ties Parkland leadership failures to ongoing patient harm, including wrong-site surgery and medication errors
Federally installed monitors at Parkland Memorial Hospital have given regulators a bleak new assessment of the crisis-plagued Dallas institution, according to a report we obtained with a Freedom of Information Act request.
"We continue to be concerned by the number of patient care, patient safety and adverse events that are continuing to occur at Parkland," says the report to the U.S. Centers for Medicare & Medicaid Services. "Throughout May and June we continued to be made aware of adverse quality and safety events including: wrong-site surgery, medication errors, patient elopements and EMTALA (Emergency Medical Treatment and Labor Act) compliance issues."
The report, dated July 16, adds: "The recurrence of these types of safety and care issues suggest[s] that changes in policies, procedures, additional training, messaging, etc. are not yet driving the level of change throughout the organization necessary to mitigate occurrence of these kinds of events.
"We believe that an underlying reason for the continuing problems in these areas can be traced in part to the level of engagement in transforming quality and culture at Parkland demonstrated by some members of the hospital's senior managers and leaders and the lack of background for several of the managers or leaders to oversee and drive a true operations 'turnaround' situation."
The monitors said Parkland is making progress in some key areas. But psychiatric care — one of its most troubled services — "made only minimal progress in June with regard to the two most important goals of securing permanent administrative leadership and consistent physician coverage."
The public hospital faces cutoff of federal funding unless it fixes its problems by April.
Stay tuned for more details. You can follow our investigative reporting team on Twitter or "like" our page on on Facebook.


text:
Ranked among the nation's most integrated healthcare systems, Community Health Network is Central Indiana's leader in providing convenient access to exceptional healthcare services, where and when patients need them—in hospitals, health pavilions, workplaces, schools and homes.
Wound, cancer, heart, maternity care and more
Call us: 317-355-1411
Find a doctor >>
Close to 1,000 babies are delivered at Community Hospital East every year. Why do families choose Community East when they are expecting a baby? Convenient access is one reason. Several outpatient locations serve the eastside—Community Health Pavilions Washington, Shadeland and East, and the Professional Building on the hospital campus. To learn more about maternity services at Community Health Network, visit eCommunity.com/ob
With a number of OB/GYN physicians practicing at Community East and a family medicine residency program with full-time faculty and residents, patients have convenient access when they need it. Patients are guaranteed to get in within 48 hours, and sometimes even the same day.
Community East offers a Saturday breastfeeding drop-in center from 11 a.m. to 1 p.m. Any mother who has questions about breastfeeding can come during the drop-in center hours to weigh her baby and get help from a hospital lactation consultant. Mothers with breastfeeding babies from any stage, newborn through weaning, are welcome. Mothers-to-be are encouraged to come ask questions and familiarize themselves with the service. Mothers who have delivered elsewhere are also welcome to take advantage of this free community service.
For more information, contact Natalie Goss, IBCLC at email@example.com, call the lactation office at 317-355-2345 or visit eCommunity.com/ob.
We are pleased to offer free tours of our maternity facilities. Please reserve a space for each person in your party by calling 800-777-7775 or register online.
But it's the quality of care that concerns most prospective parents, and that's where Community East shines. Physicians and nurses work well together, with relationships built on trust. That translates to better outcomes for patients. For example, at 17 percent, Community East's C-section rate for first deliveries is below the national average. And with highly experienced nurses at the bedside, patients receive superior, personalized care that meets their individual needs.
We are pleased to offer the following perks to patients who deliver at Community Hospital East!
With a Level II special care nursery, Community East is fully equipped to care for babies born at 32 weeks or later. It is vital that moms-to-be are seen as early in their pregnancy as possible so potential problems can be identified and handled effectively. That can be an issue for Medicaid patients who may wait 20 weeks to receive confirmation of their status. To ensure the best possible outcome for these patients and their babies, Community East assumes presumptive eligibility so they can receive early care.
Community East and the OB/GYN physicians adjust fees based on income so excellent care is within the reach of all moms-to-be. Eligible families also receive everything needed to take care of their new babies—a complimentary diaper bag, bottles, sleepers, blankets, diapers and pacifiers. And, every patient that delivers at Community East receives a free car seat and education on how to use it properly.
Patients receive free prenatal vitamins, childbirth education classes and breast-feeding classes. New moms can call Community East's lactation consultants at any time, and they even make home visits. For a fee, patients can have a doula, a birthing coach, who assists during delivery. Natural childbirth is also an option for patients.
Recent enhancements to the maternity suites include a new color palette of serene blue and warm wood-tones. The 15 spacious suites—13 of which are private— come equipped with everything patients need for the birthing experience. From the time they are admitted until they return home they stay in one room as they progress through labor, delivery, recovery and postpartum care. Each suite has a flatscreen TV, and patients are able to view interactive educational videos via the GetWell Network, so they can learn how to care for their babies on their own schedule. The renovation also included new operating tables and incubators.
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text:
Warriors are NBC champs
West Branch jumps out to early lead, holds on to beat Salem; Warriors win league outright
October 26, 2012
BELOIT — It had been 11 years since the West Branch Warriors won a Northeastern Buckeye Conference title. Friday against the Salem Quakers, they ended the streak with a 21-13 win on senior night....
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Elkins to make long journey to Huntington
November 9, 2012
Elkins will make a three-hour bus trip to the southern part of the state to battle Huntington in first round action of the Class AAA playoffs. Kickoff for the contest is scheduled for 7:30 p.m....
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|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
Hi..... may I know a new tittle of novel for this month??
have you heard ofdark shine high??"people do not need violence to solve there problems."
i just read something on dark shine high and it sounded pretty good
ive never heard of it is it iny good hm?
Ricki its new i think but wut i read bout it made it look good
it is one of my favorite manga of all time...just look at the anime forums and it said dark shine high right on it...there are two eps in the post."people do not need violence to solve there problems."


text:
These FAs need to dial back their expectations a bit... with salary cap getting across board reduction it basically equals a salary decrease vs value for all player contracts going forward.
No, you need to realise that mid-tier UFAs are "over-paid" under the CBA structure, and thats the way it is. Quality RFAs are under-paid because of the punitive compensation required for even a small offer sheet (1st and 3rd for $2 to $3M! 4 x 1sts for $5M+ !!!)