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Friday, May 17, 2013
Flowertown Players Present "Chicago"
Thursday, Friday and Saturday, May 23, 24, 25, 30, 31; June 1, 7, 8 • 8:00 p.m.
Saturday - Sunday, May 25, 26; June 1, 2 • 2 p.m.
The Flowertown Players present "Chicago" Tickets are $25. Please note that the season tickets for the 2013 - 2014 season are available for purchase at very reasonable prices.
Contact information: 875-9251 for box office; www.flowertownplayers.org
Location: James Dean Theatre, 133 S. Main Street, Summerville
Memorial Day Ceremony
Monday, May 27 • 10 a.m.
The Summerville Elks Lodge will host a Memorial Day Ceremony with this year's guest speaker Summerville Mayor Bill Collins. The ceremony will start sharply at 10:30 a.m., so please try and be there around 10 a.m.
Information: Veterans coordinator, Bob Block at 843-688-4577, or co-coordinator Linda Boomhower at 843-771-0917.
Location: Summerville Cemetery (also known as Parks Cemetery) located on Highway 17A
Sertoma cheer training scheduled
The Azalea Sertoma Club of Summerville, sponsor of the Azalea Sertoma Recreational Cheerleading program, is hosting its 2nd Annual Basic Cheer Training from 6 -7:30 p.m. on June 18 and 20, and July 16 and 18 at Doty Park (320 N. Laurel St.) in Summerville. This event is free and open to children of all ages. They are also registering, now through July 27, for the 2013 Cheer Season, and offering fundraising options to offset the registration and uniform costs.
The Azalea Sertoma Recreational Cheerleading program serves as a major fundraiser for the Azalea Sertoma Club of Summerville to support their community service endeavors. For more information; call 843-821-9708, email email@example.com, or visit them on the web at www.facebook.com/ASCSummerville.
Happenings at Faith Sellers Senior Center
Monday, May 20
10:15 a.m. Fitness Fun
Join us for various types of seated exercise such as Salsa, Chair Dancing, Boxing, and more. Let's get fit and have fun.
Tuesday, May 21
2:30 p.m. Tai Chi for Health
We are partnering with H2U to present this fun-to-learn, simplified form of Tai Chi. Known to improve your muscular strength, flexibility, balance, posture and stamina.
Wednesday, May 22
10:30 a.m. Chair Travel - Australia
Join us while we explore the sights and sounds of Australia from the comfort of our own chairs.
Thursday, May 23
9:45 a.m. Walking Club
From the center we will walk around Doty Park. Enjoy the beautiful spring weather and walk to strengthen your heart, lungs, muscles, help lower blood pressure and maintain a healthy weight.
Friday, May 24
2:00 p.m. Game Group
Bring your favorite board game and join us for fun and socialization. New members welcome!
Futsal Tryouts
The ISOL Futsal/Soccer Developmental Academy will have U15/U16 open tryouts from 5:30-7:30 p.m. May 19 at its facility located at 3337 Business Circle in North Charleston. Tryout fee is $30. For more information, visit firstname.lastname@example.com or call 471-3373.
Chargers Football
The Carolina Chargers semi-pro football organization will have tryouts from 9 a.m. until noon and from 3-6 p.m. June 8 and June 15 at the Gahagan Park football field in Summerville. The organization is affiliated with the GDFL and will begin having games in May of 2014.
Dunlap Football Camp
Former Fort Dorchester High School standout and current Cincinnati Bengal Carlos Dunlap will host the second annual Carlos Dunlap Football Camp from 8 a.m. until 2 p.m. June 1 at FDHS. The camp, for kids age 6-13, will focus on the fundamentals of football as well as skills needed to succeed in life. Dunlap and other NFL personalities will serve as instructors. Registration is scheduled for May 31. The registration fee for the camp is $20 and includes a T-shirt and lunch for campers. For more information, visit www.carlosdunlapfootballcamp.com or call 693-6538.
AR Soccer Camp
Ashley Ridge High School will host its annual soccer camp for athletes age 3-12 June 17-21 and July 8-12. Camp tuition is $60 per session. Each camper will receive a camp t-shirt. The purpose of the camp is to provide a place for all players to learn the basics of soccer. Players of all ability levels are welcome. ARHS Head Girl's Soccer Coach Mark Weaver and SHS Head Boy's Soccer Coach Jason Rasner will head a staff that is committed to helping each camper improve their skills and performance levels. For more information, call 695-4900 extension 52150 or email mweaver@dorchester2..k12.sc.us.
Elite Soccer Camp
For the second summer, Ashley Ridge High School is holding an Elite Soccer Camp. This addition to ARHS soccer camp is for those players who are ready to be challenged with a more difficult regiment of activities that will enhance their dribbling, passing and shooting skills. Participants must have at least three years of playing experience and be at least 10-years-old. For more information, call 695-4900 extension 52150 or email mweaver@dorchester2..k12.sc.us.
Junior golf camp
The Golf Club at Wescott Plantation is having registration for its summer junior golf camps for ages 8-14. Led by Perry Green, PGA Director of Instruction and 2010 Carolinas PGA Junior Golf Leader, these camps will provide youth the opportunity to play and receive tips on Tee shots, Approach shots, Sand shots, Putting, rules and etiquette. Morning session will be offered June 17-20 and July 15-18. Registration fee is $195 per week with a discount available for a second session and families registering more than one camper. For more information or to register contact Perry Green at firstname.lastname@example.com or call 817-5989.
Girls of Golf program
The Golf Club at Wescott Plantation is having registration for its LPGA/USGA Girls Golf of Charleston program. Led by Perry Green, PGA Director of Instruction and 2010 Carolinas PGA Junior Golf Leader, the program offers girls age 7-17 golf instruction, lunch, team golf events and prizes. Each participant receives an LPGA embroidered hat and polo shirt. Sessions are scheduled for June 3-7 and July 8-12. Times vary depending on age group. Cost is $100 for one week or $145 for two weeks. For more information or to register contact Perry Green at firstname.lastname@example.com or call 817-5989.
Wave hoops camp
The All American Basketball Skills Camp for boys and girls in grades 3 through 9is scheduled for June 10-13. Camp will be held from 9 a.m. until noon each day. Registration cost is $70 per camper with a half-price discount available for families with more than one child. Contact Greg Elliott at email@example.com or 816-4348 for more information.
Lady Wave hoops camp
The annual Lady Wave Basketball Camp sponsored by Greenwave Self Storage will be held June 3-5 at the Summerville High School gym. All rising fifth-graders through ninth-graders are welcome to attend the camp, which will run from 9 a.m. until noon daily. The goals of the camp are to build basketball skills and fundamentals, promote competitive play and sportsmanship, and provide fun for campers. Registration is $40. Anyone who pre-registers by May 22 will receive a camp tee shirt. For more information, contact Matt Legare at 870-7052 or visit the SHS website.
Swishing at The Swamp
Ashley Ridge High School will host the Swishing at The Swamp Basketball Camp June 17-20. Camp will run from 9 a.m. until noon daily. The purpose of the camp for boys age 6-16 is to provide the foundation for young players to develop and improve. The camp is designed for players of all ability levels and will be held in the ARHS gym. Cost is $70 per camper and includes a camp T-shirt. Head Swamp Fox Basketball Coach Brian Welch will head a staff of coaches who will supervise activities. For more information, contact Welch at 695-4900 Ext: 52188; 770-367-0457; firstname.lastname@example.com or visit http://mens-basketball.ashleyridge.schoolfusion.us for a copy of a brochure.
Pinewood tennis camps
Pinewood Tennis Director Bryant McKee and his staff will host four summer tennis camps for ages 6-13 that will run from 8:30-11:30 a.m. Monday through Thursday each week in June. Camp activities will include games and drills that will work on specific skills. Match play, team tournaments and video analysis will also be offered. Only 15 players will be accepted in each camp session to keep the player to coach ratio low. Players will be grouped according to age and skill level. Quick start format and balls will be used for younger players. Cost is $125 per camp session and will include refreshments, prizes and a camp shirt. A $10 discount is available for campers enrolling in more than one session and for families with multiple campers. Tennis racquets will be made available if needed. For more information, contact McKee at firstname.lastname@example.com or 291-3898.
Cobra wrestling clinic
The Cane Bay High School wrestling clinic will be held daily June 11-13 in the school's gymnasium from 9:30 a.m. to noon. Registration is $25 and open to all wrestlers from elementary school to high school. Camp instructors will be Cane Bay wrestling coach Tim Wash, a former state coach of the year and 14-time region coach of the year, and Cane Bay assistant coach Andrew Young, a three-time state champion for Summerville High School and All-American for Newberry College. For more information, call Wash at 261-4185.
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One moment George Hill was bent over with his hands on his knees. The next, he stood straight up surveying the court. The Indiana Pacers point guard wasn't in the game. He was on the sideline with his gold T-shirt on and a towel draped around his neck. Hill cheered, coached and slapped hands with his teammates for more than the first 7 minutes of the fourth quarter against the New York Knicks. The point guard did his damage in the third quarter, when the Pacers put some distance between themselves and the Knicks.
George Hill: And the Fans: Spark the Pacers
From IndyStar.com
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subset: commoncrawl


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Joann Eastman
(608) 663-3250
Welcome. My name is Joann Eastman. If you are interested in taking the next step towards reaching your educational goals, I am here to help answer any question you may have regarding the Graduate Education programs offered at Edgewood College. I am available to meet with you individually, or answer questions over the phone or via e-mail. Start your educational search today by contacting me at 608-663-3250 or by e-mail at firstname.lastname@example.com.
Ask Joann a Question About Edgewood College


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on November 10, 2012 - 12:01 AM
Starting in about 1885, plants were among the decorations in a house because central heating kept homes - and plants - warm in the winter, and glass windows let light into most homes.
Only a small group of plants were popular, partly because of the look of the foliage, partly because they could tolerate the dry air of the home. Boston ferns, Maidenhead ferns, palms, jasmine, citrus trees, aspidistra and mother-in-law tongue's (sansevieria) were most common. A houseplant required a large decorative pot, so ceramic jardinieres consisting of a pedestal and bowl were made by many companies like Roseville and Weller. Wooden pedestals to hold potted plants were made by Victorian cabinetmakers like Mitchell & Rammelsberg of Cincinnati, and companies like Bradley and Hubbard of Meriden, Conn., made metal plant stands. Because fewer plant stands were made than more common furniture forms like chairs, it is hard to find an interesting vintage stand. Prices are high.
Q: About 25 years ago, I bought a modern-looking side table just because I liked it. The other day I noticed that it's signed "Johan Tapp." What do you know about him?
A: Johan Tapp (1888-1939) was a Dutch designer. His furniture designswere apparently manufactured and sold by various companies. Today his pieces can sell for $200 to $2,000 or more.
Q: I have a pyrography-decorated wooden wall plaque of five kittens. It's about 12 by 8 inches. On the back, it's marked "Flemish Art Company, New York" and "866." Can you tell me anything about it or its value?
A: The word "pyrography" means "writing with fire." It's sometimes called "pokerwork" because the design is burned into the wood with a thin pokerlike tool. The earliest examples were done in China more than 2,000 years ago. The technique became popular in the United States in the late 1800s, when a method of coloring the designs by using benzoline was developed. By the early 1900s, boxes, candlesticks, plaques, novelties and furniture were being decorated with pyrographic designs. The Flemish Art Co. was the major producer of pyrographic items in the United States. The term "Flemish art" is sometimes used generically to refer to any pyrographic work. The company was in business in the late 1800s and early 1900s and sold finished pieces, unfinished pieces, woodworking supplies and pyrographic kits through Sears catalogs. Pyrographic wall plaques usually sell for less than $10 today.


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Bon Vital' 1 Gallon Oil, Lotion, Gel Pump
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It's nice to not have to deal with trying to pour from a gallon jug of gel, however I do seem to still make a mess. After you're done pumping, gel stays in the pump and it drips!
Very good quality fills bottles quickly between clients
After years of using massage oils, gels and creams, I decided to switch to massage lotion to improve the clients' experience and to improve the life span of our sheets. We are only weeks into the switch but the therapists at my center who were sure they would not like the lotion have so far been using it with good success. Of all the lotions we tried, the Bon Vital Swedish Massage Lotion has worked the best for us, as it gives us lasting glide without the need for re-application. It absorbs but does not leave the skin dry, allowing for each body part to be massaged to completion without having to pump out more lotion. We use a little more, though, for hairy or very dry clients. It feels non-greasy yet has fairly decent slip. I am glad we finally switched. Our clients walk out feeling moisturized but not oily or sticky. Smells clean.
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Can Hannibal Lecter be NBC's savior on Thursday nights?
Hannibal, a contemporary take on Thomas Harris' Red Dragon novel, will take over Do No Harm's vacant slot beginning Thursday, April 4 at 10/9c, TVGuide.com has confirmed. Series executive producer Bryan Fuller first tweeted the news Thursday evening.
Check out our complete pilot report
The thriller stars Hugh Dancy as FBI agent Will Graham and Mads Mikkelsen as the cannibalistic Dr. Lecter. The series also stars Laurence Fishburne, Eddie Izzard, Gillian Anderson, Caroline Dhavernas, and Gina Torres, among others.
NBC has failed to find a series that would gain traction on Thursdays at 10/9c this season. Do No Harm was canceled after only two episodes when a mere 2.2 million viewers tuned in for its second outing, a 22 percent drop from its premiere.
View original NBC Sets Premiere Date for Bryan Fuller's Hannibal at TVGuide.com
Related Articles on TVGuide.com
- Check out our complete pilot report
Other Links From TVGuide.com
- Caroline Dhavernas
- Eddie Izzard
- Gillian Anderson
- Gina Torres
- Hugh Dancy
- Laurence Fishburne
- Mads Mikkelsen
- Do No Harm
- Hannibal
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Football Takes Down CMU, Stays Unbeaten in MAC
MUNCIE, Ind. -- Keith Wenning threw four touchdown passes and Willie Snead set the Ball State record for single-season TD catches as the Cardinals posted a 44-24 victory Wednesday night over Central Michigan.
Ball State extended its winning streak to seven straight in the nationally televised game on a rainy night at Scheumann Stadium. Horactio Banks ran for a career-high 143 yards on just 11 carries, helping the Cardinals (9-1) move to 6-0 in MAC play for the third time ever. Central Michigan dropped to 3-6 overall (2-3 MAC) with the loss.
Ball State, which has won 11 consecutive MAC games dating back to last season, travels to face nationally ranked Northern Illinois next Wednesday in a game with major MAC West Division title implications.
"We are very happy to get a win tonight, to be 9-1 at this point and to continue to be in the hunt for a championship," Ball State head coach Pete Lembo said.
Wenning threw three of his touchdown passes Wednesday in the first 17 minutes of the game -- one each to Snead, Jordan Williams and Jamill Smith -- as Ball State built a 21-0 lead early in the second quarter.
Banks added the Cardinals' fourth touchdown of the half and Ball State took a 31-3 lead into the break. The Ball State defense, which forced three turnovers in the first half, held an opponent to just three first-half points for the second time in three games.
"We liked the way our guys came out of the gate," Lembo said. "They were focused, and it looked like the couple extra days between games paid off. We really kept our foot on the gas in the second quarter and built a nice lead going into the intermission."
The second of three Scott Secor field goals gave Ball State its largest margin of the day at 34-3 early in the third quarter. The Cardinals also led 41-10 before a pair of fourth-quarter touchdowns by the Chippewas, including one by CMU quarterback Cooper Rush, who passed for 284 yards and accounted for two touchdowns on the day.
Snead caught his record-breaking touchdown with 3:39 left in the third quarter on a 1-yard pass from Wenning. It was the 12th score of the season for the junior receiver, surpassing the previous record of 11 by Darius Hill in 2007. Snead also tied a school record with his 11th career 100-yard receiving game.
Ball State will play its second straight game on ESPN2 in next week's showdown at Northern Illinois. Kickoff is set for 8 p.m. ET Wednesday in DeKalb, Ill., as the MAC West Division rivals battle for the Bronze Stalk Trophy.
First Quarter
Ball State 7, Central Michigan 0
11:09 – Keith Wenning 8-yard touchdown pass to Jordan Williams. Scott Secor kick good.
9 plays, 75 yards, 3:51
Ball State 14, Central Michigan 0
3:44 – Keith Wenning 13-yard touchdown pass to Willie Snead. Scott Secor kick good.
3 plays, 96 yards, 1:10
Second Quarter
Ball State 21, Central Michigan 0
13:41 – Keith Wenning 30-yard touchdown pass to Jamill Smith. Scott Secor kick good.
5 plays, 82 yards, 1:54
Ball State 21, Central Michigan 3
8:57 –Ron Coluzzi 30-yard field goal.
12 plays, 57 yards, 4:38
Ball State 24, Central Michigan 3
4:56 – Scott Secor 28-yard field goal.
11 plays, 56 yards, 3:55
Ball State 31, Central Michigan 3
1:17 – Horactio Banks 25-yard touchdown run. Scott Secor kick good.
5 plays, 39 yards, 1:22
Third Quarter
Ball State 34, Central Michigan 3
9:38 – Scott Secor 31-yard field goal.
10 plays, 64 yards, 3:35
Ball State 34, Central Michigan 10
6:49 – Zurlon Tipton 1-yard touchdown run. Ron Coluzzi kick good.
7 plays, 75 yards, 2:44
Ball State 41, Central Michigan 10
3:39- Keith Wenning 1-yard touchdown pass to Willie Snead. Scott Secor kick good.
7 plays, 88 yards, 3:06
Fourth Quarter
Ball State 41, Central Michigan 17
14:54- Cooper Rush 26-yard run. Ron Coluzzi kick good.
11 plays, 56 yards, 3:55
Ball State 44, Central Michigan 17
2:51 – Scott Secor 26-yard field goal.
7 plays, 22 yards, 4:05
Ball State 44, Central Michigan 24
1:33 – Cooper Rush 22-yard touchdown pass to Titus Davis.
3 plays, 56 yards, 1:13


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The Way of zūmo®
The Way of zūmo is focused. zūmo premium GPS motorcycle navigators are designed and built to serve those who ride, with left-hand optimized interfaces and high-sensitivity touchscreens made to be glove-friendly. The Way of zūmo is innovative: zūmo leads the market with features designed to ease riders' minds and stoke passion for the road. The Way of zūmo is seen and heard with large, bright displays that are easily read – even in direct sunlight – and music and Bluetooth® connectivity options. On the road or off track, the Way of zūmo is rugged, tough enough to withstand brutal elements and harsh weather conditions.Not all features included in all models. See specific product pages for details.
The Way of zūmo awaits.
- Large 5" sunlight-readable touchscreen display
- Dual-orientation display
- Easily find places Up Ahead, like food and gas stations, without leaving the map
- Navigate complex interchanges with ease
- 3-D Terrain
- Custom and TOPO map support (additional mapping sold separately)
- Monitor motorcycle tire pressure on the zūmo display with the TPMS accessory (sold separately. Metal valve stems only)1
- High-sensitivity, glove-friendly touchscreen
- Left-hand optimized interface
- Easily find addresses and millions of points of interest
- Includes MP3 player; iPod® and Pandora®2 compatibility lets you control music right on the display
- Hands-free phone control and spoken directions heard in-helmet via Bluetooth® technology3
- Garmin Real Directions™ guide like a friend, using landmarks and traffic lights
- Rugged and tough enough to withstand harsh weather conditions (water rating: IPX7)4
- Resistant to fuel spills and UV rays
- Weather and traffic info via Smartphone Link5 app
- Service History Log to record bike maintenance
- Curvy Roads routing navigates to winding rides
- Off-road track support
- TracBack® can return you along the same route
- Round trip routing can automatically plan a ride, based on time, distance or location
- Free lifetime map updates6
- Motorcycle and automotive mounts included
- Compatible with VIRB™ HD action camera (sold separately), so you can record and relive every ride
- Download FREE VIRB Edit desktop editing software for intuitive, robust video editing. When you are ready to share your latest riding adventure, upload for all your friends to see.
Choose your zūmo.
|Display size
|Dual-orientation display
|Music & media control (including Pandora®)
|Live traffic and weather radar via Smartphone Link app
|Supports custom maps
|3-D Terrain
|Active Lane Guidance
|Up Ahead
|Round trip routing
|Removeable battery
|Dual headset support
|Hands-free phone control via Bluetooth® technology
|Hear spoken directions via Bluetooth® helmet/headset
|Free Lifetime maps of USA, Canada & Mexico
|Compatible with TOPO maps
|Curvy Roads
|Service History Log
|Water rating: IPX7
|Motorcycle mount included
|Automotive mount included
|TPMS compatible
|VIRB™ compatible (wireless start/stop control)
|Buy Now
|Buy Now
1 The system works with up to 4 tires in any configuration, additional purchase required for each wheel. Metal valve stems only. Not intended for automotive use. 2 Music and Media control work with iPhone® 3GS or later, and some iPod® devices. Pandora® works with iPhone 3GS or later and some Android™ devices. Pandora is currently available in the United States, Australia, and New Zealand. 3 Requires Bluetooth®-compatible helmet, headset or smartphone. Sold separately. 4 Water Rating Definitions. 5 User's data plan charges, if any, will apply. Subscription required. 6 Lifetime Maps Terms & Conditions The Bluetooth® word mark and logos are owned by the Bluetooth SIG, Inc. and any use of such marks by Garmin is under license. Other trademarks and trade names are those of respective owners. iPhone® and iPod® are trademarks of Apple, Inc., registered in the U.S. and other countries. Android is a trademark of Google Inc. PANDORA, the PANDORA logo, and the Pandora trade dress are trademarks or registered trademarks of Pandora Media, Inc. Used with permission.


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The U.S. Army Corps of Engineers and the Greening of the Mississippi
Centralized technological systems, even when based on good science and sound engineering, can have bad consequences. In this personalized history, Todd Shallat demonstrates that point for concerned citizens using the example of the U. S. Army Corps of Engineers and the Mississippi River. The role of public works infrastructure as part of the problem and the solution is a central issue.


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Developers of DTC Genetic Testing Are...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Protein microarrays are many things to many people. Like the more mature DNA "chips", they are often patterns of tiny spots arrayed on a microscope-type slide, used to determine the makeup and amount of protein in a sample in a multiplex fashion. But not always.
Just as there are a wide variety of uniplex protein assays, there are a variety of multiplex protein assays as well. Chips, yes—but they're also found arrayed on the bottom of microwell plates and as beads in a tube. These, and others, were hot topics at BIT Life Sciences' recent "PepCon" protein and peptide conference.
Protein chips are typically laid out by using a contact pin spotter or a noncontact microarrayer to immobilize ligands on a substrate. These can be antibodies, aptamers, peptides, or other molecules whose binding affinity is used to query samples. In the case of peptides, arrays can be created from random libraries for biomarker discovery, for example, or from series of overlapping protein sequences for epitope mapping.
For PEPperPRINT's PEPperCHIP® microarrays, peptides are synthesized directly on a functionalized glass slide with a 20-color laser printer. The activated amino acids, which are embedded in the toner, are released from the solid matrix material upon melting. "The toner matrix liquefies and the activated amino acids can approach amino groups on the surface of the chip," explained CEO Volker Stadler, Ph.D., "and that way they can couple covalently to form the peptides on the chip." Up to 20 mers are produced by sequential rounds of heating, washing, and deprotection.
Toner is heated to just above the melting temperature of the amino acids so there is little or no evaporation. "And because the toner matrix has an oily consistency, it doesn't spread on the slide surface. This is a key feature that allows us to achieve much higher spot densities compared to other technologies."
Another major advantage of this approach, Dr. Stadler added, is that the combinatorial laser-printing process allows for one-off microarrays to be easily produced. "It's the same effort to synthesize hundreds of different or hundreds of the same peptide microarrays." Thus the Heidelberg-based biotech can offer custom microscope slide-sized arrays with about 9,000 peptides on a slide for around c900, or about c0.10 per feature. These high-density arrays allow for low per-feature reagent consumption as well, typically requiring only about 5–10 microliters of sample per chip.
Standard PEPperCHIPs can be processed and read with standard lab equipment. PEPperPRINT also offers larger slide formats with up to 275,000 features.
The company, which has been developing its technology for the past decade, began offering screening services in early 2010. In March of this year it started marketing chips for its customers to use in-house. It is currently focused on serology and antibody analysis—"it's the most straightforward way to work with peptide chips," Dr. Stadler said.
The chips can also be used for kinase, acetylase, deacetylase, and other enzymatic analyses, "but we don't have enough experience in the field to really know that they work as well as for standard applications," Dr. Stadler confessed. "So we have collaborators testing the chips now" to see how they perform and to elicit feedback on how to improve them for enzymatic assays.
Robert Sack, Ph.D., SUNY College of Optometry professor, uses conventional commercial microarrays in slightly unconventional ways, and in the process has come to some disturbing conclusions about standard protocols.
Specifically, he uses planar arrays and microwell plate arrays, along with techniques such as HPLC and immunoprecipitation, to identify and characterize the chemokines and cytokines in lacrimal fluid.
"There is a tremendous difference in the host defense mechanism between the open and closed eye," Dr. Sack says. While the eye is closed, there is a fluid layer with no place to go. Bacteria stimulate epithelial cells, which in turn recruit immune cells to digest the microorganisms, the result being high levels of peroxidases, proteases, interferons, interleukins, and TNF alpha. "You have a tissue, the cornea, which is lying right next to it and is extremely vulnerable to any change. Any neovascularization, any scarring, can have a devastating effect. Yet the eyes of a person in a coma can stay closed for years without any major effect."
Earlier work had shown that protease inhibitors were released from the ocular surface, and Dr. Sack wanted to know how the cytokines were kept in check. In his research, he found that "virtually all the inflammatory cytokines and immune modulating cytokines were in the form of macromolecular inactive complexes."
Many of these were not detectable using standard microarray protocols, or they gave wildly varying results. Yet under the right conditions, Dr. Sack was able to show that the cytokines were complexed with soluble receptors and another protein that tags it for destruction.
Tears contain various surfactants and other substances with a high affinity for plastic, and thus show a high nonspecific reactivity in many assays. Using the correct blocking agents and "running proper controls, such as spiking samples with different types of tears from different individuals (because the levels of these interfering factors vary enormously from one sample to another)," are only part of the solution.
Because the cytokines are found in complexes, they may not be detectable using the antibodies supplied by the assay manufacturer. "The way I was able to show these complexes was to take standard arrays and substitute antibodies for the complexing proteins in place of the normal secondary antibody," Dr. Sack explained. Complexes were isolated by molecular sieve HPLC and characterized.
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Not since 1995 has a team other than Adams State or Western State claimed the Rocky Mountain Athletic Conference cross country championship.
After Saturday, that streak is 17 years and running.
Adams State � ranked first nationally in the NCAA Division II men�s top 35 and second in the women�s poll � swept the RMAC Cross Country Championships on Saturday at Monument Valley Park.
Nationwide, the RMAC championships is becoming known as �mini-nationals.� Adams State beat five teams ranked in the men�s top 35 and four ranked in the women�s top 35.
The Adams State men�s cross country program won its 34th RMAC championship, 22 more than Western State�s next best. And history has been kind to the best team in arguably the best cross country conference in the nation; 16 of the last 20 national championships have come from the RMAC, including the last four.
Tabor Stevens and Alicia Nelson paced the Grizzlies with individual conference championships and subsequently were named the men�s and women�s RMAC Runners of the Year.
Kevin Batt, who finished fourth for Adams State, was named the RMAC Freshman of the Year.
Damon Martin, the architect of the national powerhouse and a 30-time national coach of the year, is the men�s and women�s RMAC Coach of the Year.
No. 1 Adams State won its men�s championship with 30 points (1-4-6-8-11).
No. 2 Adams State won its women�s championship with 21 points (1-2-4-5-9).
Fort Lewis College finished seventh (190) in the men�s race and fifth (194) in the women�s race.
�For us, it was kind of a measure to see where we matched up with teams that were near us for regionals,� FLC cross country head coach Mark Dutro said. �We went into the meet to beat who we could and get as close as we could to everyone else.�
No. 2 Colorado School of Mines finished second behind the Adams State men with 44 points, then was followed by No. 4 Western State (67), No. 9 UC-Colorado Springs (102) and No. 34 N.M. Highlands (180).
No. 4 Western State finished second behind the Adams State women with 46 points, then was followed by No. 15 UC-Colorado Springs (94) and No. 14 Colorado Mines (103).
Kiprono Mutai paced the FLC men�s team in 32nd place. He ran the 8 kilometers in 26 minutes, 49.6 seconds.
Stevens won the 8K in 25:06.90, four seconds faster than Phil Schneider of Colorado Mines.
For the FLC men�s cross country team, Christian Gering finished 36th (27:06.70), Garrett Sapakoff finished 41st (27:16), Jimmy Mohrbacher finished 52nd (27:56.30), Joey Brenner finished 53rd (28:02.50), Derek Laue finished 58th (28:19.90), Alex Kilman finished 60th (28:23.10), Josh Benson finished 73rd (29:04.40), and Tate Lagasca finished 82nd in the 105-runner field in 29:27.
�Part of it is we just wanted to show that we�re legit, that some of the rankings we�ve had aren�t a fluke,� Dutro said.
�That was kind of our purpose, to maybe scare somebody.�
The FLC men are ranked eighth regionally, while the women are unranked.
For now.
Alexis Work paced the FLC women�s team in 25th place. She ran the 6K in 24:08.50.
Nelson won in 21:57.10. Her teammate, Kelly Lamb, finished runner-up in 22:13.70.
For the FLC women�s cross country team, Maddie Kruger finished 33rd (24:34.20), Katarina Medici finished 41st (24:52.90), Tara Dillon finished 46th (25:05.90), Helen Smith finished 63rd (25:59.20), Alyssa Carman finished 71st (26:18.90), and Katherine Judge finished 84th in the 107-runner field in 26:55.90.
�The women finished a lot higher than I think people considered us,� Dutro said.
�Bottom line: That�s that we wanted to do.�


text:
ROCKFORD — Terese Burch, president of Saint Anthony College of Nursing, recently testified against funding cuts for hospital-affiliated colleges of nursing during a congressional staff briefing in Washington, D.C. The presentation took place Jan. 27. The purpose was to alert U.S. legislators that changes in administrative and accreditation expectations are affecting clinical nursing education funding, according to a news release. In her testimony, Burch emphasized the high graduation rates, post-graduation rates and pass rates on the national license exams that hospital-based colleges produce. The briefing was hosted by U.S. Sen. Dick Durbin, D-Ill., and the National Alliance for Nursing Education. For information: sacn.edu.
Location, ST | website.com


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About Sears
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In 1925, Sears opened their first brick and mortar store on a sprawling 40 acre compound that would include a shipping warehouse, catalog printing plant, headquarters and office complex. Sears continued to expand well into the 1950s, at which time they focused efforts on entering the suburban markets and malls. In 1974, Sears claimed its place at the top of the retail ladder by completing the world famous Sears Tower, which at the time was hailed the tallest building in the world. The Sears Tower would serve at the company's consolidated headquarters for the next two decades.
Today, Sears has more than 1,300 branded and affiliated stores in the US, Canada and Puerto Rico, including 790 full-line stores and 50 specialty retail locations. Sears also owns K-Mart and Land's End brands as well.
You can learn more about Sears on Wikipedia and Wikidata.


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"The taxpayers and residents of Lehigh County deserve to know exactly what we're getting into, how it's going to affect their rates," said Schware.
The East Penn Chamber of Commerce passed a motion recommending a charter extension be granted to LCA so it can continue to participate in the Allentown water/sewer lease process, said Kevin Baker, president of that chamber. He told commissioners East Penn businesses and communities deserve to a bid "in the non-profit model" to be presented by LCA.
Allentown's final request for proposals was supposed to be sent to LCA and five other potential bidders on Monday, according to city officials, but it still had not been posted on the city's website by Wednesday night's commissioners meeting.
"We don't even know what's in that yet," said Arndt. To be ready to submit a bid, he indicated LCA must continue working on the assumption it will get approval from commissioners.
Ott expressed skepticism about why the city's final request for proposals still had not been released. He said it's almost comical how little information commissioners are getting about such a big decision.
Schware agreed and said everyone is operating on an artificial time frame established by Allentown and its mayor. "They need to change that," he said. "They need us more than we need them. They're the ones that need the money for their pension system."
He said the city's multi million dollar pension problem, which is what Allentown hopes to solve by leasing the sewer water and sewer systems for around $200 million, was created by "rushing" and he doesn't want that mistake to be made again.


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Sebring American Legion Ladies Aux. to continue food drive
November 4, 2012
SEBRING — The Sebring American Legion Post 76 Ladies Auxiliary met recently with President Judy Hubbs presiding. It was announced that the food drive continues through Nov. 1....
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on December 21, 2012 - 12:21 AM
, updated December 21, 2012 at 4:35 PM
A friend's father-in-law just went into an assisted care home, and he frequently complains about being bored. I made the obvious suggestion, "Can you give him some books?"
She replied, "He doesn't read." This was a foreign concept to her, and me.
"I can't imagine not reading," she said. "It would be awful. You would have to live your whole life in the real world. You could never escape to anywhere else."
Long before I was a writer, I was a reader. I escaped into books, both highbrow and trashy, ever since I was a child.
But it wasn't until my early 20s that I turned to reading as a form of personal development. Prior to that, nonfiction was something that teachers assigned, grindingly boring tomes that you read only because you had to, and you forgot right after the test.
Then I read "The Road Less Traveled" and everything changed. For the first time I realized that books aren't always about other people, sometimes they're about me.
Here are seven books that had a transformative effect on my thinking, and thus, my life:
1. "The Road Less Traveled" by M. Scott Peck, MD.
Peck's classic stands the test of time. I read it in my 20s, then my 30s, and again in my 40s. Each time I gained a deeper understanding of myself, my relationships and where I still needed (and wanted) to grow. If you read it 20 years ago, read it again, you'll be surprised by new insights.
2. "Do What You Are" by Paul Tieger and Barbara Barron Tieger.
Even if you're familiar with Myers-Briggs methodology, this book will help you more concretely understand which aspects of a job will be natural for you and what will be loathsome. It helped me discover that I was born, literally, to help people and organizations find their higher purpose.
3. "Nurture by Nature" also by the Tiegers.
Applying Myers-Briggs to parenting taught me how to nurture my "different from me" daughter in a way that matched her personality. It transformed what could have been a frustrating experience into the most rewarding (and successful) experience of my life.
4. "Getting the Love You Want" by Harville Hendrix.
Hendrix's paradigm shifting concepts helped my husband and me shed childhood baggage we didn't even realize we had. The process wasn't easy, but it led us to a much better, more grown-up marriage.
5. "A Return to Love" by Marianne Williamson.
An Oprah favorite, this book delivers on its promise by showing you how to use love as a path toward inner peace. It contains Williamson's famous quote, "Our deepest fear is not that we are inadequate. Our deepest fear is that we are powerful beyond measure. It is our light, not our darkness, that most frightens us."
6. "Good to Great" by Jim Collins.
Yes, a business book changed my life. Collins' classic remains that standard bearer for great leadership and doing work that matters. The Big Hairy Audacious Goal is a game-changer that can be applied to everything.
7. "The Politics of Hope" by Donna Zanjonc.
Back in 2004, long before "The Audacity of Hope," former Oregon State Rep. Donna Zajonc explained why the two-party war wasn't working, and laid out an inspiring alternative. We're not there by a long shot, but every time I get depressed, I remember her quote, "The declaration of our interdependence will comprise the next phase of our political evolution."
Every one of these books is available online. Happy reading.


text: Hey everyone, I don't post to the site very often, but I do visit almost everyday, and enjoy reading the insight posted by the folks who visit the site. I came across this video tonight that recaps the last 22 years of playoff appearances made by our beloved Red Wings, and felt the need to share with everybody in this hockey community. Hopefully you take the 22 minutes and 22 seconds (ironic, huh?) that it takes to watch the video in its entirety, and enjoy it as much as I did! Go Wings!


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LEWISTOWN - Stephen C. McIntyre, 58, of Lewistown, died Thursday, Nov. 22, 2012, at his residence.
Born May 16, 1954, in Altoona, he was a son of the late William H. "Mac" and Ruth M. (Tate) McIntyre.
Surviving are: sister, Laurie A. Woomer and husband, James Jr., of Altoona; brother, Jeffrey W. and wife, Barbara, of Thompson, Manitoba, Canada; and a niece, Kristin McIntyre.
Article Photos
Stephen C. McIntyre
Stephen was a 1972 graduate of Hollidaysburg Area Senior High School.
He was formerly employed as office manager at Bell Telephone Company, Pittsburgh, Laskaris Restaurant, Lewistown, and the Senior Services Agency, serving Mifflin County.
He was an active member of Lewistown Presbyterian Church, where he served as deacon, and recently received nomination as elder.
A funeral service will be held at 11:30 a.m. Thursday, Nov. 29, 2012, at Sorge Funeral Home Inc., 422 N. Juniata St., Hollidaysburg, with the Rev. James R. Thomas officiating. Interment will be held in Alto Reste Park Cemetery.
Family will receive friends from 1 to 3 p.m. Wednesday, at the funeral home.
A memorial service will be held at 10 a.m. Wednesday, Dec. 5, 2012, at Lewistown Presbyterian Church, 17 E. Third St., Lewistown.
In lieu of flowers, memorial donations may be given to the local Humane Society donor's area.
Arrangements are entrusted to Sorge Funeral Home Inc. www.sorgefuneralhome.com.


text:
on October 4, 2012 - 8:01 PM
, updated October 4, 2012 at 10:12 PM
A onetime substitute teacher and baseball coach in the Ken-Ton School District, who pleaded guilty to "sexting" boys on the team, was sentenced Thursday to 30 days in jail and five years of probation.
Robert Leary, 29, was told by Tonawanda Town Justice J. Mark Gruber to report to jail this afternoon. His sentence will be served in the Erie County Correctional Facility in Alden.
Leary pleaded guilty, as charged, in June to two counts of endangering the welfare of a child and one of aggravated harassment. The maximum sentence for each of the misdemeanor charges is a year in jail.
Leary had worked less than a year for the school district – until October 2011 – and had been a middle school baseball coach. The accusations came to light after he no longer was working there.
Between June and December 2011, Leary sent inappropriate and sexually suggestive text messages to three juveniles and requested sexual images from them, authorities said previously. He reportedly also made threats to keep the boys from telling their parents about his texts.
Before imposing sentence Thursday, Gruber heard from Peter Marche, an assistant Erie County district attorney; defense attorney John R. Nuchereno; and Leary. However, much of what they said was inaudible to those seated in the courtroom gallery.
Marche noted that the parent of a victim was in the courtroom and referenced a victim impact statement. He said Leary deprived the victims "of an innocence they will never get back."
Leary is a "troubled young man" and is receiving professional help, according to his attorney.
"The real question is the punishment," said Nuchereno, adding that the punishment Leary suffers on a daily basis is "enormous."
In his comments, Leary mentioned a letter he wrote to the court, the contents of which weren't disclosed.
The judge noted a request by the prosecutor for orders of protection for all of the victims and witnesses in the case. "They all are seeking to have absolutely no contact with the defendant," Marche said. "I stress that's no contact whatsoever."
It took several minutes for Gruber to recite the terms of probation, several of which essentially bar Leary from contact with people under age 18 or, in certain circumstances, require him to be accompanied by a responsible adult or an approved chaperone.
Provisions apply to where Leary may live, work and visit; with whom he may associate; and even with whom he may become romantically involved, if that person has children.
Alcohol and drug use is prohibited, and Leary is subject to random testing. There also are restrictions on computer and phone usage; he isn't allowed to have a cellphone with photo or video capability.
Leary also is required to have various evaluations by professionals.
Gruber granted the orders of protection sought by the prosecutor. They apply to seven people and will prevail throughout the probation period.
email: email@example.com


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Blog: Auto
Do We Need EVs with Turbo Engines Becoming so Fuel Efficient?
Shane McGlaun
October 17, 2011 1:15 PM
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You're doing it wrong.
Turbos are on 75% of new cars sold in Europe
You don't have to be a scientist or an automotive engineer to look at the fuel economy that major automakers are squeezing out of their vehicles with normal combustion engines today and wonder if we really need EVs and hybrids. More than one diesel car in Europe is able to provide fuel economy as good or better than the hybrids people generally think are so fuel thrifty.
The catch is that we rarely see diesel engines in the US inside a car, that will be changing, but the diesel car isn't common today for American drivers. One thing that is becoming very common for fuel efficiency sake is the addition of a turbocharger to allow a smaller displacement engine to produce acceptable power to provide the performance drivers expect.
The turbocharger is something that was often thought of for performance cars like the Grand National Buick in the mid to late 1980's. Today the turbo is used in a number of engines including the very popular EcoBoost line from Ford. Ford's EcoBoost engine inside the
F-150 truck
is selling very well and has a towing capacity on par with normal engines with larger displacement. The turbocharger is even more widely used in Europe where
reports that 75% of all new cars come with one.
Craig Balis from Honeywell Turbo Technologies told Reuters in an interview, "The turbocharger is a green technology in the sense that it's helping cut emissions and raise fuel economy. It's a critical component to get more fuel efficiency out of the engine."
"Emissions regulations in Europe, the United States and worldwide are a driving force for cleaner, greener vehicles and that's a great landscape for turbocharging," said Balis. "We're confident about the continued evolution of combustion engines and the growing role turbocharging has."
reports that a diesel engine that has a turbocharger can get 40% more mileage than one without a turbo and a gas engine can go 20% further per liter of fuel than one without a turbo. With the impressive economy that normal engines with turbochargers achieve there are many that wonder if we even need EVs and hybrids.
Pierre Gaudillat, policy officer at the Transport and Environment lobby group in Brussels, was asked if we need EVs from a CO2 point of view. He said, "That's a valid question. The answer is: maybe not. Turbos are a no-brainer for cutting CO2 because the efficiency gains are really quite significant. In the near term, we don't really need and can't count on electric vehicles to deliver the CO2 savings. Maybe not until about 2030 or 2050."
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This article is over a month old, voting and posting comments is disabled
RE: Stop spreading misconceptions about Turbos
Such a comparison is not really instructive because there are too many other factors. Mainly:
1. The Japanese turbos you specify are all permanent four wheel drive, which impacts on fuel economy. Gearing and things also affect the highway economy in particular, they're not what-so-ever targeted at highway cruising.
2. There's a massive difference between a high-boost turbocharged car like the Evo and the low pressure turbos in most of those 75% of cars sold in Europe (a lot of which are probably even diesels). The Evo idles at 1500rpm. I read that the newer twin-scroll BMWs hold max torque from 1250rpm.
3. Comparing the maximum power outputs can be very inadequate. From first-hand experience, my previous car was a 4.0L inline 6, my current car a 2.5L turbocharged inline 5. The max power and torque figures are almost the same for both cars, but the 2.5L engine feels so much more powerful because that max torque is almost all available from 2000rpm below to 2500rpm above where the other engine hit that peak.
What the turbo gives you is the ability to use a smaller capacity, so you do without having the extra weight of a large engine (both in terms of components in reciprocating motion and just the block, head, etc), the extra friction, the extra pumping loss pumping a larger capacity, etc. Things like cylinder deactivation, direct injection, continuously variable valve lift, etc, are not as good as reducing the capacity and they can be applied to smaller engines anyway. With the turbo, you still have the ability to effectively scale up the engine displacement to get more power as needed. With low pressure turbos there's basically no perceptible lag, and you get the sort of low-end torque and drivability that means you don't need to rev high (which would generate a lot of friction and negate a lot of the benefits of smaller capacity). In terms of economy for petrol engines, it is quite effective at the moment. I don't really see what it has to do with hybrids though, if a turbo would be of benefit to the hybrid's ICE then they should use one, it'd still be less CO2 emissions than the non-hybrid.
If you want to see a better comparison, compare the 1.6L Ecoboost Focus engine to the 2.0L naturally aspirated petrol, both new engines from the same manufacturer in the same car. The 1.6L Ecoboost is noticeably better from a drivability perspective (270Nm torque@1900-5000rpm and 134kw versus 202Nm torque@4450rpm and 125kw@6600rpm). Even with that massive difference (looks like you really need to ring the neck of that 2L), the 1.6L is more economical (139g vs. 154g C02/km). There's also a NA version of the 1.6L to compare to if you wanted.
Make a similar comparison with the engine choices across VW's Golf, and look at their twincharge engines.
It's quite obvious that these low pressure turbos provide very substantial benefits for drivability, and for the economy you can achieve when you're targetting a specific level of performance.
"It's okay. The scenarios aren't that clear. But it's good looking. [Steve Jobs] does good design, and [the iPad] is absolutely a good example of that." -- Bill Gates on the Apple iPad
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On the Hill, brought to you by the Tahoe Center for Orthopedics, brings you a video report showcasing Tahoe's ski conditions every day.
Breakdown: Join Tahoe 'On the Hill' reporter Matt Hardy for a cruise down Gold Coast on this gorgeous bluebird day in Lake Tahoe.
Squaw Valley official report: 4" overnight, 4" in last week.
Tahoe Daily Tribune field report: Beautiful day. Crisp air, groomed runs, and new snow are making for a great surface.
Liftline status: The Funitel and Gold Coast weren't crowded at 10:15, and not likely to change until the weekend. Keep in mind Squaw is operating 10 a.m. – 3 p.m.
Run of the day: Gold Coast was groomed with new snow.
Weather: Sunny and cold today, with temps the low 20s.
Snowcast: The best snow of this young winter season is heading for Tahoe this weekend. The prospects for the next Sierra storm keep getting better. We are now looking at a very good chance of between 12 and 18 inches of snow at the highest elevations of the Sierra Friday night through Saturday. Some spots along the Sierra Crest could see up to 24 inches. The snow should start late Friday night and peak early Saturday morning. Highs Saturday will be in the high teens or low 20s around the Lake with lows in the single digits through the weekend.
What do you think of On the Hill? Any adventures you'd like to see? Contact us at firstname.lastname@example.com
Like On the Hill on Facebook, and check out all the videos from Vail and Lake Tahoe.


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Cheer on your favorite team in this Nike Tackle tee! You love cheering for the Houston Texans and you wear your team colors any chance you get. Featuring printed Houston Texans graphics on the front, there will be no doubt that you're a very stylish fan!
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Shop Software at a glance
So you know what matters
xt:Commerce 4 is the ideal shop software for you to create your own online shop. The core of our software is its structure. The decisive aspect of this modular plug-in system is: The software can also be optionally expanded really easily by adding further modules over numerous interfaces – for any size of business and for an unlimited number of products!
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Biographies & Memoirs
Read the uplifting biographies, memoirs and stories from people of faith-some who have come before us and others who still walk with us on this Earth. These inspiring, motivation books from Family Christian, shared by famous and everyday people alike, remind us how God can transform, heal and restore our lives.
Taking My Life Back: My Story of Faith, Determination, and Surviving the Boston Marathon Bombing
Rebekah Gregory, Rebekah Gregory, Anthony FlaccoRegular Price: $19.99 Special Price $13.99Add Your ReviewOn April 15, 2013, Rebekah Gregory and her five-year-old son waited at the finish line of the Boston Marathon to support a friend who was running. When the blasts of terrorists' homemade bombs packed with nails and screws went off three feet away, Rebekah's legs took the bru... Learn More
This Life I Live: One Man's Extraordinary, Ordinary Life and the Woman Who Changed It Forever
Rory FeekRegular Price: $24.99 Special Price $19.99Add Your ReviewJoey and Rory Feek were enjoying a steadily growing fan base in country music when Joey was diagnosed unexpectedly with a rapidly spreading cancer. This vibrant and beautiful young woman would soon be on a unique journey for which no one is ever fully prepared. Her husband, ... Learn More
Inside the NFL's First Family: My Life of Football, Faith, and Fatherhood
Bruce Matthews, James Lund, Howie Long, James L. Lund$26.00Add Your ReviewFrom the man who has played in more NFL games than any non-kicker in the football league s history comes a memoir about the Matthews family and how seven people over three generations have achieved success in the NFL more than any other family in sports history. No family ha... Learn More
Courage to Soar: A Body in Motion, A Life in Balance
Simone Biles, Simone Biles, Mary Lou Retton, Michelle BurfordRegular Price: $24.99 Special Price $14.99Add Your ReviewSimone Biles' entrance into the world of gymnastics may have started on a daycare field trip in her hometown of Spring, Texas, but her God-given talent, passion, and perseverance have made her one of the top gymnasts in the world, as well as a four-time winner of Olympic g... Learn More
The Right Steph: How Stephen Curry Is Making All the Right Moves--With Humility and Grace
Mike Yorkey$9.99Add Your ReviewIn the last couple of years, Stephen Curry has reshaped the way basketball is played, been proclaimed the best shooter in basketball history (with the stats to back him up), morphed into the baby-faced face of the NBA, and has been lauded by many experts as the best player o... Learn More
Seven Women: And the Secret of Their Greatness
Eric Metaxas$16.99Add Your ReviewMeet extraordinary women who heard God's call and faithfully responded! In the follow-up to his acclaimed 7 Men, Metaxas shows how Joan of Arc, Susanna Wesley, Hannah More, Maria Skobtsova, Corrie ten Boom, Mother Teresa, and Rosa Parks lived by the gospel---and changed the ... Learn More
The Magnolia Story
Chip Gaines, Joanna GainesRegular Price: $26.99 Special Price $19.99Add Your ReviewComing in October 2016, The Magnolia Story is the first book from Chip and Joanna Gaines, hosts of the hit HGTV house flipping television show Fixer Upper. Through renovating homes in Waco, Texas, and changing lives in such a faithful and engaging way, Chip and Joanna have ... Learn More
Bartholomew: Apostle and Visionary
John Chryssavgis, Pope Francis$26.99Add Your ReviewThe Orthodox Church, that great beacon of the East, now boasts 300 million members worldwide. In one of the most remarkable tenures of the patriarchate it has been more than twenty-five years since Bartholomew first accepted this ministerial position, which is considered "fi... Learn More
My Brother's Keeper
Rod Gragg$26.00Add Your ReviewFeatures thirty captivating profiles of Christians who risked everything to rescue their Jewish neighbors from Nazi terror during the Holocaust. My Brother's Keeper unfolds powerful stories of Christians from across denominations who gave everything they had to save the J... Learn More
At Home in Exile: Finding Jesus Among My Ancestors and Refugee Neighbors
Russell Jeung$17.99Add Your ReviewRussel Jeung's spiritual memoir shares the joyful and occasionally harrowing stories of his life in East Oakland's Murder Dubs neighborhood. Includes stories about battling drug dealers, exorcising a spirit possessing a teen, and winning a landmark housing settlement against... Learn More
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OLD FORT - Christian Kiesel scored twice and Morton Mogelmose had two assists to help Columbian hold off Old Fort 5-3 Tuesday.
Kiesel scored in each half, with his first goal giving the Tornadoes (3-7) a 2-1 lead and his second pushing the advantage to 4-1.
But the Stockaders roared back off the leg of Cole Davidson.
The senior, who snapped a scoreless tie in the 11th minute, booted in two goals in a six-minute span after Kiesel's second score to bring Old Fort to within 4-3.
But Alec Demith padded Columbian's lead by converting a Mogelmose pass in the 64th minute and the Tornadoes turned away Old Fort from there.
Garrett Bean had TC's first goal in the 18th minute off a Mogelmose pass to tie the game at 1.
Josh Gibson stopped 12 shots for TC, and Matt Wilson had seven for the Stockaders.
Hardy-led Stritch drops Mohawk
OREGON - Kaylee Hardy scored three times Tuesday to key Cardinal Stritch's 3-1 girls soccer win over Mohawk.
Voe Waldbuesser added seven saves for the Cardinals (4-4).
Kim Danner had the lone goal for the Warriors (4-5), converting a pass from Cambria Kohlenberg. Liz Runion stopped 11 shots for Mohawk, which was out-shot 14-8.


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Upshur County Tobacco Coalition members spoke recently to the Buckhannon City Council, requesting support of a policy that would prohibit the use of tobacco in public parks and recreational facilities in the city.
Some councilmen and city officials appeared to favor the concept, but had concerns about the policy.
Joyce Harris-Thacker and Amanda Hayes, members of the tobacco coalition, adapted the policy they presented to council from Clarksburg, changing only the name of the city. They are hopeful that the same policy enacted in Buckhannon would reduce second-hand smoke, eliminate confusion of which facilities are tobacco-free, reduce litter and show kids that smoking is not OK.
City attorney David McCauley expressed his concern that the policy would need a penalty to be enforced. He said if an activity is prohibited, a criminal sanction is required. If the Buckhannon City Council adopts a criminal sanction, it would require an ordinance rather than a policy.
"I support the council's movement in that direction if that's where you want to go," McCauley said. "But we need to think it through."
The council did not make a decision and will continue to review the matter.
"There's a movement in the community, that they would really like to see you pass this policy," Hayes said, adding that some members of the community cannot come to public events because of the dangers of second-hand smoke because of asthma or other health reasons. She said there is no safe level of exposure to second-hand smoke.
"I'm quite in favor of such a policy, but I'm also not a smoker and never have been," City Recorder Richard Clemens said. "I really don't care for the smoke. I'm glad that our restaurants are smoke-free and so on, but that's not universally accepted."
Harris-Thacker said that she thinks business has boomed since the indoor smoking ban for public restaurants was enacted.
She said it was because people who would otherwise have stayed at home could now eat out, even if smoking is still somewhat of an issue at restaurant entrances.
"When I go to places, even outside of restaurant doors, I've suffered through people smoking," she said. "Literally, I have to rush by and hold my breath. That's infringing on my rights. They can have their counter-claim, and they have the right to do that. But it's my air, too."
Clemens suggested having an area of the public parks designated for smoking, but Councilman Ron Pugh said that would depend on which way the wind blew as to where the smoke would travel.
"I can tell you right now, there is no tobacco smoke-free zone anywhere," he said.
Harris-Thacker was opposed to the idea of designated smoking areas in public parks.
"I think designating an area would be that much harder to enforce, in my opinion, than it would be to just declare the recreations, parks and facilities smoke free and see how it goes," Harris-Thacker said.
"We all have rights to smoke. We have rights not to smoke." Pugh said. "I think it should be that, if we have the smoke-free zones in our parks, then the smokers out there should honor that and be nice enough to go across the street or go some place if they have to have a cigarette."
Contact Melissa Toothman by email at email@example.com.


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TAHOE/TRUCKEE, Calif. _ I'm telling you, serving stuffed figs makes anyone look like a contestant on The Next Great Chef. They are just so chi-chi and fancy looking. Plus, no one ever tries to cook a fig because they are somehow intimidating, despite the fact they really are super easy to prepare. Right now figs are sitting neglected in your grocer aisle, just begging for a home, waiting to be plucked off the shelves. And plucked they are, not picked, as they do bruise easily. But who cares? Not you! You are going to stuff, wrap and broil those babies, hiding any man-handling damage they might have incurred en route. The following recipe is foolproof, and I have given you a couple of options, based on budgetary restrictions - or not. Either way, these figs are going to elevate you to gourmet status whether you're ready or not. I now leave you with a little poem to celebrate your new culinary role in the community...
The Fig Plucker's Son
I am not a fig plucker,
Nor a fig plucker's son.
But I'll pluck figs
till the fig plucker comes.
Stuffed Figs
8 Black Mission Figs, cut in half, length-wise
1/2 cup Boursin cheese or a mixture of cream and blue cheese
8 slices prosciutto, sliced length-wise (pulled apart is easier)
2 Tbls. olive oil
course sea salt and pepper
Turn on broiler. Place fig halves on cookie sheet. Put about a teaspoon of cheese on each fig and wrap the figs with the prosciutto, making sure the ends touch. Broil two minutes on each side, until the prosciutto is crisp. Remove from oven and drizzle with olive oil then sprinkle with salt and pepper. Variation: Substitute cream cheese for Boursin or blue mixture, and bacon for prosciutto. Equally delicious, sometimes preferable because you taste more of the figs' sweetness.


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Main Content
- 100% Cotton
- 2 Are designed in team colors with contrast trim; 1 is heather gray and displays "Tiny Fan" text
- Lap shoulders and snaps at the bottom promise easy dressing and changing
- Made in El Salvador
- Officially licensed
- Ribbed trim details the collars and leg openings
- Set of 3 short-sleeve creepers
- Decorated with NHL team logos
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JEFFERSON CITY, Mo. — Holidays are a time to spend with friends and family. People are off from work, children are home from school, and friends and family are visiting. Looking for something fun to do? Discover nature at the Missouri Department of Conservation (MDC) Runge Nature Center's Holiday Happenings Open House from 10 a.m. to 3 p.m. on Friday, Dec. 27, and 10 a.m. to 3 p.m. on Saturday, Dec. 28.
"Our theme this year is Nature by Design," said MDC Runge Nature Center Manager Kathy Cavender. "From the subtle sounds of snow falling in the woods to the shapes of trees and hills, winter is a great time to see nature in new ways."
Discover nature at the free public event through activities for children, teens and adults including I Spy nature games, natural shapes scavenger hunt, winter weed arrangements, stories, crafts, refreshments, and more.
Runge Nature Center is located on Hwy 179 in Jefferson City approximately .5 miles north of Hwy 50. Building hours are 8 a.m. to 5 p.m., Tuesday through Saturday with extended hours until 8 p.m. on Thursdays. The building is closed on Sunday and Monday. The outdoor trails are open from 6 a.m. to 9 p.m. daily.
For more information on this or other programs, call 573-526-5544 or visit mdc.mo.gov and search "Runge."


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Traffic on 23rd Avenue and U.S. 34 near the Greeley Mall was frozen for about a half hour on Sunday afternoon as Greeley police talked a woman down from committing suicide.
Greeley police officer Ryan Templeman spoke to the woman for about 20 minutes as her legs dangled over the edge of the U.S. 34 overpass on the eastbound side, said Greeley police Sgt. Steve Black.
"He was able to talk her into bringing her legs back over from the edge" after she contemplated jumping, Black said.
Traffic on 23rd Avenue going northbound and southbound, as well as eastbound U.S. 34, were closed throughout the process, he said. One lane on U.S. 34 westbound remained open.


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BELLEVILLE - David J. "Spike" Spicher, 60, of 5 Charity Drive, Belleville, died at 2:30 p.m. Sunday, April 21, 2013, at his home.
Born June 18, 1952, in Bellevile, he was a son of the late Jessie D. and Annie L. (Yoder) Spicher. His first wife, Arlene (Yoder) Spicher, preceded him in death on April 3, 2003. His second wife, Esther (Sharp) Spicher, whom he married on Nov. 24, 2005, survives.
He is survived by: children, Marlin J. Spicher and wife, Mary Ann, of Mifflin, Grace M. Beachy and husband, Gene, of Belleville, John W. Spicher, of Paraguay, and David J. "Sonny" Spicher Jr. and wife, Benita, of Huntingdon; grandchildren, Chavis, Denise, Jeffrey, Rebecca, Ciara, Caiden and Jordan Spicher and Dallas, Genea and Kylie Beachy; siblings, Naomi Yoder and husband, Aquilla, of Belleville, Anna Mae Yoder and husband, Noah, of Burgettstown, Susan Peachey and husband, Joe I., of Cuthbert, Ga., Mary Etta Miller and husband, Daniel, of Harrison, Ariz., Abe L. Spicher and wife, Marlene, of Middlebury, Ind., Jesse Lee Spicher and wife, Ruth, of Belleville, Lois Kauffman and husband, Jesse M., of Belleville, Ruth Kauffman and husband, Joseph, of Belleville; and brothers- and sisters-in-law, Jenny Spicher, of Bethany Beach, Del., Everett Hostetler, of Sarasota, Fla., David S. Sharp and wife, Sara Ann, of Milroy, Sally Peight and husband, Edward, of Mount Union, Grace E. Sharp, of Belleville, Noah Sharp and wife, Viola, of Lewistown, Joe Sharp and wife, Martha, of Belleville, N.Y., and Dan Sharp and wife, Karen, of Belleville. David is also survived by Nora Yoder, who is an aunt to David to Arlene. She resides with David and Esther.
He was preceded in death by: a grandson, Arlin D. Spicher, on Jan. 23, 2001; a brother, Paul Spicher; a sister, Rhonda Hostetler; and a brother- in-law, John Sharp.
He most recently was a taxi driver for the Amish and sold Cen-Pe-Co products. Prior to that he drove truck for Kauffman Excavating.
David enjoyed spending time with his family. He was a member of Pleasant View Amish Mennonite Church, where he served as a Sunday school teacher for a number of years.
His funeral service will be held at 10 a.m. Friday, April 26, 2013, at Pleasant View Church, with Ministers David Byler, Melvin Roes and David J. Peachey officiating. Burial will be in Locust Grove Cemetery.
His family will receive friends from 2 to 4 p.m. and 6 to 8 p.m. Thursday, April 25, at the church.
Arrangements are under the care of Henderson Funeral Home Inc., 3813 W. Main St., Belleville.


text:
Colon Cancer, and how we can help.
Being diagnosed with colon cancer is life changing. In a flash, you're faced with questions and concerns — and the stress of the unknown. That's where we come in. We give you answers, relieve your fears, and help you make the right plan. Our doctors and specialists assess your condition and treat you with the best tools available. Why do we do all this? Simple. We want what you want — the best possible result.


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Wall Street Decline Takes Its Toll...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Arthur Brown, M.D., Ph.D., president and CEO of ChanTest, summed up the sentiments of a number of speakers at the recent "SBS Conference" in Lille, France, when he said, "Ion channels are as abundant as GPCRs in the known druggable genome and have as much potential as drug targets for pain, hypertension, and inflammation. Yet they still don't receive the time and attention they should from drug developers."
Kim Dekermendjian, Ph.D., senior research scientist in molecular pharmacology at AstraZeneca, agreed, adding "only seven percent of current drug targets are ion channels while 30 percent are GPCRs, so ion channels are totally underexploited and this is because historically it has been so difficult to screen them in a rational way."
Since ion channels are a diverse family of pore-forming proteins that control the voltage gradient and ionic flow across the plasma membrane, it is well established that the most accurate method of measuring a drug's effects on an ion channel is via patch clamping.
This works by forming a patch through which intracellular access is gained to measure and control membrane voltage and current flowing through the cell membrane. In the past five years relatively low-throughput automated patch clamps such as the QPatch from Sophion Bioscience, the Patchliner from Nanion Technologies, and the PatchXpress® and IonWorks® Quattro™ systems from Molecular Devices, a MDS Analytical company, have emerged. The cost per data point, however, has made these automated methods too expensive to use in primary screening.
According to Dr. Dekermendjian, sometimes the screening costs of using these systems, even in secondary screens, is referred to at AstraZeneca as "tears per data point". As a result, surrogate measures of ion-channel activity such as ligand displacement, ionic flux, and membrane potential are used as primary screens with equipment including the Molecular Devices FLIPRTetra®, the most commonly used.
The disadvantage of using these assays is they cannot maintain a population of ion channels in a particular conformational state due to the lack of voltage control and so need to be used as methods to weed out the best drug candidates for a confirmatory patch-clamp screen. "The surrogate measures are nonfunctional and cannot identify allosteric modulators," noted Dr. Brown. "Ion-channel sites for allosteric modulators are enormous and relatively untapped."
Despite the shortcomings of the screening technologies available, many pharma and biotech companies are investigating ion channels as drug targets for some interesting applications. An example of this is ChanTest's combination of surrogate assays and patch-clamping technologies for repurposing old drugs.
"With more than 86 cell lines of HEK and CHO cells expressing ion channels screened by fluorescence assay and patch clamp we provide the largest collection of validated ion channels for screening," explained Dr. Brown.
"Using these cells we screened a library of compounds that had been withdrawn, suspended, or discontinued at late-stage clinical trials. Many of these were potent hERG blockers, something that sends regulatory authorities into seizure mode but because they showed no adverse human cardiac events we decided these could be a useful group of compounds to test as potential treatments for, in this example, cardiac diseases.
"From primary screens using the FLIPRTetra, we produced 10,000 data points per day. Any promising compounds we screened using IonWorks Quattro to generate 2,000 data points per day, followed by a PatchXpress or QPatch screen to produce 100 data points per day," Dr. Brown said.
"Finally, those compounds that produced the best results were screened again by manual patch clamp which, because it is so difficult and time consuming, only produces seven data points per day. From this funneled screening approach, we identified a compound we call CT-1, and its ion-channel profile showed it would be an appropriate drug candidate for atrial fibrillation."
Dr. Brown presented data demonstrating that CT-1, in both IV and oral dosage form, is well tolerated in canine models and Phase 1 dose-escalating studies for atrial fibrillation. He also showed that in a Phase II study of 27 patients with atrial fibrillation 12/20 receiving the drug converted to having normal sinus heart (NSR) rhythms within two hours of having CT-1 treatment.
"We're pleased with the Phase II trial results because the usual rate of patient conversion from atrial fibrillation to NSR is 30 percent and we're achieving 60 percent," Dr Brown concluded. "CT-1 is going to be out-licensed soon, and we're using the same integrated screening methodology to repurpose two other drugs because we estimate it can reduce the pre-clinical development time and Phase I work by several years."
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